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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

The Antiviral Potential of ERK/MAPK and PI3K/AKT/mTOR Signaling Modulation for MERS-CoV Infection as Identified by Temporal Kinome Analysis.
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a lineage-C betacoronavirus and infections with this virus can result in acute respiratory syndrome with renal failure. Globally, MERS-CoV has been responsible for 877 laboratory-confirmed infections, including 317 deaths, since Septermber, 2012. As there is a paucity of information regarding the molecular pathogenesis associated with this virus, or the identities of novel antiviral drug targets we performed temporal kinome analysis on human hepatocytes infected with the Erasmus isolate of MERS-CoV (MERS-CoV) with peptide kinome arrays. Bioinformat...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2014 Category: Microbiology Authors: Kindrachuk J, Ork B, Hart BJ, Mazur S, Holbrook MR, Frieman MB, Traynor D, Johnson RF, Dyall J, Kuhn JH, Olinger GG, Hensley LE, Jahrling PB Tags: Antimicrob Agents Chemother Source Type: research

Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.
Abstract GSK1322322 is a novel antibacterial agent under development with known antibacterial activity against multi-drug resistant respiratory and skin pathogens through inhibition of bacterial peptide deformylase. Here we used Next Generation DNA sequencing (NGS) of the bacterial 16S rRNA from stool samples collected from healthy volunteers at pre-dosing and end-of-study time points to determine the effects of GSK1322322 on the gastro-intestinal (GI) microbiota in a Phase I, randomized, double-blind, placebo-controlled study. GSK1322322 was administered either only intravenously (IV-only) or in oral/IV combinatio...
Source: Antimicrobial Agents and Chemotherapy - December 8, 2014 Category: Microbiology Authors: Arat S, Spivak A, Van Horn S, Thomas E, Traini C, Sathe G, Livi GP, Ingraham K, Jones L, Aubart K, Holmes D, Naderer O, Brown JR Tags: Antimicrob Agents Chemother Source Type: research

Dimensional structure of bodily panic attack symptoms and their specific connections to panic cognitions, anxiety sensitivity and claustrophobic fears.
Conclusions. Taking into account the dimensional structure of panic attack symptoms may help to increase the specificity of the associations between the experience of panic attack symptoms and various panic related constructs. PMID: 25482960 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - December 8, 2014 Category: Psychiatry Authors: Drenckhan I, Glöckner-Rist A, Rist F, Richter J, Gloster AT, Fehm L, Lang T, Alpers GW, Hamm AO, Fydrich T, Kircher T, Arolt V, Deckert J, Ströhle A, Wittchen HU, Gerlach AL Tags: Psychol Med Source Type: research

Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.
CONCLUSION: Recipient risk factors for ARDS rather than transfusion risk factors predominate in pTRALI. PMID: 25488517 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - December 8, 2014 Category: Hematology Authors: Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR Tags: Transfusion Source Type: research

Central neurogenic hyperventilation: A sign of CNS lymphoma
A 69-year-old man complained of "breathing too fast" for 6 weeks. He was a recovered alcoholic with essential tremor, hypertension, depression, and history of stage IE diffuse large B-cell lymphoma of the left femur diagnosed 3.5 years earlier and treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone. Six weeks prior to presentation, the patient noted an increased respiratory rate and shortness of breath, and was found to have new atrial fibrillation; he underwent unsuccessful atrial ablation. He had a 3-month history of malaise, cold intolerance, and a 10-pound weight loss. He also complaine...
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Pantelyat, A., Galetta, S. L., Pruitt, A. Tags: Clinical neurology examination, All Neuro-ophthalmology, All Oncology, Metastatic tumor Cases Source Type: research

Intranasal naloxone administration for treatment of opioid overdose.
CONCLUSION: Intranasal administration of naloxone appears to be effective in treatment of opioid overdose when i.v. administration is impossible or undesirable. PMID: 25465584 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - December 7, 2014 Category: Drugs & Pharmacology Authors: Robinson A, Wermeling DP Tags: Am J Health Syst Pharm Source Type: research

A comprehensive examination of delayed emotional recovery in borderline personality disorder
Conclusions Findings indicate that individuals with BPD generally do not exhibit delayed emotional recovery, but may show decreases in parasympathetic activity during the recovery period after experiencing anger. However, this pattern may not be specific to this disorder. (Source: Journal of Behavior Therapy and Experimental Psychiatry)
Source: Journal of Behavior Therapy and Experimental Psychiatry - December 7, 2014 Category: Psychiatry Source Type: research

Toxic inner ear lesion following otitis media with effusion: a comparative CT-study regarding the morphology of the inner ear
Abstract Viral infections of the upper respiratory airways can lead to a delayed viral otitis media (VOM) caused by a diffusion of viruses/virus particles through the round window membrane and resulting in sensorineural hearing loss. The treatment of choice is immediate paracentesis, evacuation of all fluids from the middle ear cavity, and haemorrheological infusions. However, in some cases, persistent symptoms may be an indication for a surgical approach using mastoidectomy. In high-resolution computed tomography, an extended small-sized pneumatisation of the mastoid cells with complete shading was found in these...
Source: European Archives of Oto-Rhino-Laryngology - December 7, 2014 Category: ENT & OMF Source Type: research

Early Lesions following Aerosol Challenge of Rhesus Macaques (Macaca mulatta) with Mycobacterium tuberculosis (Erdman Strain)
Publication date: Available online 4 December 2014 Source:Journal of Comparative Pathology Author(s): E.L. Rayner , G.R. Pearson , G.A. Hall , F. Gleeson , A. McIntyre , D. Smyth , M.J. Dennis , S.A. Sharpe Three rhesus macaques (Macaca mulatta) were challenged with Mycobacterium tuberculosis (Mtb), Erdman strain, as part of studies to investigate lesion development at early time points in tuberculosis (TB) and to assess computed tomography (CT) as a method of monitoring disease progression in vivo. Animals were challenged with either a high, mid or low dose of aerosolized Mtb. The low-dose animal was killed humanely at...
Source: Journal of Comparative Pathology - December 7, 2014 Category: Pathology Source Type: research

Protective Effects of Intranasal Immunization with Recombinant Glycoprotein D in Pregnant BALB/c Mice Challenged with Different Strains of Equine Herpesvirus 1
Publication date: November 2014 Source:Journal of Comparative Pathology, Volume 151, Issue 4 Author(s): N.A. Fuentealba , C.N. Zanuzzi , M.R. Scrochi , G.H. Sguazza , M.E. Bravi , V. Cid de la Paz , S.G. Corva , E.L. Portiansky , E.J. Gimeno , C.G. Barbeito , C.M. Galosi Equine herpesvirus (EHV)-1 induces respiratory infection, neurological disorders and abortion in horses. Most of the currently available attenuated or inactivated vaccines against this infection are administered intramuscularly and only provide partial protection against the respiratory disease. The present study examines the effect of intranasal immuniz...
Source: Journal of Comparative Pathology - December 7, 2014 Category: Pathology Source Type: research

Skeletal Muscle Hypoplasia Represents the Only Significant Lesion in Peripheral Organs of Ruminants Infected with Schmallenberg Virus during Gestation
Publication date: August–October 2014 Source:Journal of Comparative Pathology, Volume 151, Issues 2–3 Author(s): F. Seehusen , K. Hahn , V. Herder , M. Weigand , A. Habierski , I. Gerhauser , P. Wohlsein , M. Peters , M. Varela , M. Palmarini , W. Baumgärtner Schmallenberg virus (SBV), an arbovirus within the family Bunyaviridae, represents a ruminant pathogen that has caused epidemic abortion and birth of malformed or stillborn animals in many European countries since August 2011. Histological and immunohistochemical analysis of peripheral tissues of SBV-infected animals, including lymphoid tissues, endocrine organ...
Source: Journal of Comparative Pathology - December 7, 2014 Category: Pathology Source Type: research

The Recent European Isolate (08P178) of Equine Arteritis Virus causes Inflammation but not Arteritis in Experimentally Infected Ponies
In conclusion, infection of naïve animals with the European 08P178 strain of EAV is associated with inflammation, but not arteritis. (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - December 7, 2014 Category: Pathology Source Type: research

Ivabradine in cardiogenic shock: Fact or fiction?
Publication date: Available online 6 December 2014 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Kadir Uğur Mert , Gurbet Özge Mert , İbrahim Altun , Murat Biteker (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - December 7, 2014 Category: Respiratory Medicine Source Type: research

Effects of hyperoxic exposure on signal transduction pathways in the lung
Publication date: Available online 6 December 2014 Source:Respiratory Physiology & Neurobiology Author(s): Andrea Porzionato , Maria Martina Sfriso , Andrea Mazzatenta , Veronica Macchi , Raffaele De Caro , Camillo Di Giulio Exposure to supraphysiological concentrations of oxygen is often applied in clinical practice to enhance oxygenation in acute or chronic lung injury. However, hyperoxic exposure is associated with increased reactive oxygen species production, which can be toxic to pulmonary endothelial and alveolar epithelial cells. Oxidative stress activates the pathways of the mitogen-activated protein kina...
Source: Respiratory Physiology and Neurobiology - December 7, 2014 Category: Respiratory Medicine Source Type: research

Therapeutic Potential of Garcinia Kola with Reference to the Restoration of Inhibited Acetylcholinesterase Activities in Induced Clarias gariepinus
This study was conducted to assess the antidotal prospect of Garcinia kola seeds extract in restoring the activity of inhibited Acetylcholinesterase. This was done by inducing Clarias gariepinus with the enzyme inhibitor (glyphosate pesticide formulation). The fish divided into six groups were exposed different treatments; the pesticide alone, the G.kola seed extract alone and different mixture of the pesticide and G. kola seeds extract. AChE activities in the brain, liver and serum of the fish were measured in the experimental and control fish on day -7, 14, 21 and 28th by the colorimetric method. The enzyme was significa...
Source: Beni Suef University Journal of Basic and Applied Sciences - December 7, 2014 Category: Science Source Type: research

A HCO3−-dependent mechanism involving soluble adenylyl cyclase for the activation of Ca2+ currents in locus coeruleus neurons
This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease. (Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease)
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - December 7, 2014 Category: Molecular Biology Source Type: research

Relationship between clinical signs and results of impulse oscillometry in pigs originating from the field
Publication date: Available online 1 December 2014 Source:Research in Veterinary Science Author(s): C. Püllen , S. Becker , P. Reinhold , H.-J. Smith , G. Reiner The aim of the present study was to assess the contribution of clinical data to the variability of impulse oscillometric test results observed previously by Püllen et al. (2014). Fifty-eight German hybrid pigs from 29 different herds with unknown respiratory status were examined in the context of routine diagnostics as part of herd health service. Routine clinical examination was extended to a total set of 29 parameters, representing detailed clinical signs of...
Source: Research in Veterinary Science - December 7, 2014 Category: Veterinary Research Source Type: research

Effectiveness of pre-peritoneal continuous wound infusion with lidocaine for pain control following ovariohysterectomy in dogs
This study compared the post-operative analgesic efficacy of continuous lidocaine administration with that of intramuscular (IM) methadone in dogs undergoing ovariohysterectomy. Thirty-eight dogs were divided randomly into two groups. Following surgery, the lidocaine group (L) received a continuous lidocaine infusion (2 mg/kg/h) through a wound catheter inserted in the pre-peritoneal space; the control group (C) received methadone (0.2 mg/kg IM). A dynamic and interactive visual analogue scale (DIVAS), the Scale-Form Glasgow Composite Measure Scale (CMPS-SF), mechanical wound thresholds, heart rate, respiratory rate an...
Source: The Veterinary Journal - December 7, 2014 Category: Veterinary Research Source Type: research

Malignant degeneration of pulmonary juvenile-onset recurrent respiratory papillomatosis
We present a patient with JORRP in which lung disease underwent malignant transformation during adolescence. Our goal is to raise awareness of the potential for malignant transformation in children, as well as to familiarize pediatric radiologists with imaging features of malignant lung disease in JORRP. We advocate for the identification of the subgroup of JORPP patients with pulmonary disease who, due to increased risk for malignant transformation, may benefit from closer clinical and imaging surveillance by a multidisciplinary team. (Source: Pediatric Radiology)
Source: Pediatric Radiology - December 7, 2014 Category: Radiology Source Type: research

Inhibition of AMPK expression in skeletal muscle by systemic inflammation in COPD rats
Conclusion: Such findings indicate that AMPK may serve as a target for therapeutic intervention in the treatment of muscle weakness in COPD patients. (Source: Respiratory Research)
Source: Respiratory Research - December 7, 2014 Category: Respiratory Medicine Authors: Yong QiJun-yi ShangLi-jun MaBei-bei SunXin-gang HuBao LiuGuo-jun Zhang Source Type: research

Pelagitalea pacifica gen. nov., sp. nov., a New Marine Bacterium Isolated from Seawater.
Abstract A strictly aerobic, Gram-negative, beige-pigmented, short-rod-shaped, non-motile and chemoheterotrophic bacteria, designated K2-48(T) was isolated from seawater collected in the Western North Pacific Ocean near Japan. Preliminary analysis based on the 16S rRNA gene sequence revealed that the novel isolate was affiliated with the family Oceanospirillaceae within the class Gammaproteobacteria and that it showed the highest sequence similarity (93.7 %) to Neptunomonas qingdaonensis P10-2-4(T). The strain could be differentiated phenotypically from recognized members of the family Oceanospirillaceae. The majo...
Source: Current Microbiology - December 7, 2014 Category: Microbiology Authors: Lee H, Yoshizawa S, Kogure K, Kim HS, Yoon J Tags: Curr Microbiol Source Type: research

Fluticasone furoate and vilanterol inhalation powder for the treatment of chronic obstructive pulmonary disease
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - December 6, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Anxiety disorders and physical comorbidity: increased prevalence but reduced relevance of specific risk factors for hospital-based mortality during a 12.5-year observation period in general hospital admissions.
Authors: Schoepf D, Heun R Abstract Anxiety disorders (AD) are associated with an increase in physical comorbidities, but the effects of these diseases on hospital-based mortality are unclear. Consequently, we investigated whether the burden of physical comorbidity and its relevance on hospital-based mortality differed between individuals with and without AD during a 12.5-year observation period in general hospital admissions. During 1 January 2000 and 30 June 2012, 11,481 AD individuals were admitted to seven General Manchester Hospitals. All comorbidities with a prevalence ≥1 % were compared with those of 114,...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 6, 2014 Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research

A review of treatment strategies for hydrofluoric acid burns: Current status and future prospects
Publication date: December 2014 Source:Burns, Volume 40, Issue 8 Author(s): Xingang Wang , Yuanhai Zhang , Liangfang Ni , Chuangang You , Chunjiang Ye , Ruiming Jiang , Liping Liu , Jia Liu , Chunmao Han Hydrofluoric acid (HF), a dangerous inorganic acid, can cause severe corrosive effects and systemic toxicity. HF enters the human body via where it contacts, such as skin and mucosa, alimentary and respiratory tracts, and ocular surfaces. In the recent years, the incidence of HF burn has tended to increase over time. The injury mechanism of HF is associated primarily with the massive absorption of HF and the release of h...
Source: Burns - December 6, 2014 Category: Dermatology Source Type: research

The impact of inhalation injury in patients with small and moderate burns
Conclusions Inhalation injuries significantly reduced the survival rate, especially when the BI was less than 50. The possibility of pulmonary dysfunction and complications arising from inhalation injury should be considered even in patients who have small cutaneous burns associated with inhalation injuries. (Source: Burns)
Source: Burns - December 6, 2014 Category: Dermatology Source Type: research

Influence of inhalation injury on energy expenditure in severely burned children
Conclusions Inhalation injury does not augment the burn-induced hypermetabolic stress response in children, as reflected by resting energy expenditure and oxygen consumption. (Source: Burns)
Source: Burns - December 6, 2014 Category: Dermatology Source Type: research

A Novel Monocarboxylate Transporter Inhibitor as a Potential Treatment Strategy for γ-Hydroxybutyric Acid Overdose
Conclusion The novel and highly potent MCT inhibitor represents a potential treatment option for GHB overdose. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - December 6, 2014 Category: Drugs & Pharmacology Source Type: research

21st Century Oral Hairy Leukoplakia – a non-HIV associated entity
Conclusion In the 21st Century, the presence of OHL should not be regarded as pathognomic for HIV infection or significant systemic immunosuppression. Local and systemic immunosuppression, in the form of steroid inhaler usage, is a risk factor for the development of OHL. (Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology)
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - December 6, 2014 Category: ENT & OMF Source Type: research

The association of cold weather and all-cause and cause-specific mortality in the island of Ireland between 1984 and 2007
Conclusions: The study findings indicated strong cold weather-mortality associations in the island of Ireland; these effects were less persistent, and for CVD mortality, smaller in NI than in the ROI. Together with suggestive differences in associations by age and gender between the two Irish jurisdictions, the findings suggest potential contribution of underlying societal differences, and require further exploration. The evidence provided here will hope to contribute to the current efforts to modify fuel policy and reduce winter mortality in Ireland. (Source: BioMed Central)
Source: BioMed Central - December 6, 2014 Category: Journals (General) Authors: Ariana ZekaStephen BrowneHelen McAvoyPatrick Goodman Source Type: research

Nosology of idiopathic phrenic neuropathies
Abstract Phrenic neuropathies (PN) are an important cause of dyspnoea, orthopnoea and hypercapnic respiratory failure. However, there is no agreement on the nosology of this disorder. The aim of this cohort study was to analyze the author’s and published PN patients and compare them with other immune-mediated focal neuropathies to determine the most appropriate nomenclature and classification of the disorder. All patients with PN referred to the author from March 2004 to March 2013 were included. In addition, to identify previously published patients with PN, a PubMed search was done. The demographic and clinica...
Source: Journal of Neurology - December 6, 2014 Category: Neurology Source Type: research

A prospective survey of idiopathic interstitial pneumonias in a web registry in Japan
Conclusions This study should provide valuable information for understanding the current state of IIP in Japan. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Essential rules and requirements for global clinical trials in rare lung diseases: A sponsor׳s standpoint
Publication date: Available online 26 November 2014 Source:Respiratory Investigation Author(s): Thomas Kuerner International multicenter trials have the advantage of being able to recruit many patients within a short period. This is particularly useful for rare diseases. Ideally, conclusions drawn from the results of a global clinical trial apply to all study centers and countries involved, potentially expediting drug development and facilitating approval in foreign markets. However, several challenges must be overcome to ensure optimal trial conduct and coordinate trial sites working under different regulations and tech...
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Stratifying the risk of COPD exacerbation using the modified Medical Research Council scale: A multicenter cross-sectional CAP study
Publication date: Available online 18 November 2014 Source:Respiratory Investigation Author(s): Kazuto Matsunaga , Atsushi Hayata , Keiichiro Akamatsu , Tsunahiko Hirano , Tsutomu Tamada , Tadashi Kamei , Tohru Tsuda , Hiroyuki Nakamura , Tsuneyuki Takahashi , Soichiro Hozawa , Yoshihiro Mori , Yukihiro Sakamoto , Keiji Kimura , Uichiro Katsumata , Motohiko Miura , Masakazu Ichinose (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults
Conclusions This study demonstrated that the heritability of pulmonary function traits can be explained by the additive effects of multiple common SNPs in healthy Japanese adults. The pulmonary function genes reported in previous GWASs of non-Japanese populations showed a definite impact of the genes on FEV1/FVC, thus indicating the presence of common pathways related to this trait beyond ethnicity. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Disease flare after gefitinib discontinuation
Conclusions Our analysis demonstrated a lower incidence rate of disease flare after gefitinib discontinuation compared with the previous report, but the prognosis was similarly poor. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Endobronchial ultrasound-guided transbronchial biopsy with or without a guide sheath for diagnosis of lung Cancer
Conclusion EBUS-GS with TBB, brushing, and bronchial washing is effective in diagnosing lung cancers sized <20mm. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

An analysis of etiology, causal pathogens, imaging patterns, and treatment of Japanese patients with bronchiectasis
Conclusions Idiopathic and sinobronchial syndrome were common causes of BE. Etiology did not contribute to imaging pattern or predictors of exacerbations. Cystic BE was a predictor for frequent exacerbations in the non-NTM BE patients. (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Current status and study activity of lung cancer in Japan
Publication date: November 2014 Source:Respiratory Investigation, Volume 52, Issue 6 Author(s): Toshihiro Nukiwa (Source: Respiratory Investigation)
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research

Clinical significance of epidermal growth factor receptor tyrosine kinase inhibitors: Sensitivity and resistance
Publication date: November 2014 Source:Respiratory Investigation, Volume 52, Issue 6 Author(s): Shinji Takeuchi , Seiji Yano Gefitinib and erlotinib, which are epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs), are highly effective against lung tumors with EGFR activating mutations. However, in 20–30% of cases, there is intrinsic resistance, and even if the treatment is effective, resistance is acquired in one to several years. Possible mechanisms of acquired resistance to EGFR-TKI, thus far, include a gatekeeper mutation of EGFR, activation of an alternate pathway, activation of EGFR downs...
Source: Respiratory Investigation - December 6, 2014 Category: Respiratory Medicine Source Type: research