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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Classifying patients by their characteristics and clinical presentations; the use of latent class analysis
Abstract In this article, we introduce the general statistical analysis approach known as latent class analysis and discuss some of the issues associated with this type of analysis in practice. Two recent examples from the respiratory health literature are used to highlight the types of research questions that have been addressed using this approach. (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Darren Wraith, Rory Wolfe Tags: Invited Review Series: Modern Statistical Methods in Respiratory Medicine Source Type: research

The relationship between fat‐free mass index and pulmonary hyperinflation in COPD patients
ConclusionsFFM index was weakly associated with peak exercise IC in COPD patients. However, it ceased to be an independent predictor when corrected for expiratory airflow limitation (FEV1) and lung hyperinflation at rest (rest IC). (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Leonardo Silveira, Paulo José Zimermann Teixeira, Cassia C. Costa, Rafael M. Souza, Pietro Krauspenhar Merola, Caroline Colombo, Renata D. Marques, Danilo C. Berton Tags: ORIGINAL ARTICLE Source Type: research

The pathogenesis of pneumothorax in Birt–Hogg–Dubé syndrome: A hypothesis
The development and natural course of lung cysts in patients with Birt–Hogg–Dubé syndrome (BHD) is still unclear, and the relationship between lung cysts and pneumothorax is not fully clarified. Based on the follow‐up results of thoracic imaging in six patients with BHD, we hypothesize that decreased potential for stretching of the cysts' wall and extensive contact with the visceral pleura are probably responsible for rupture of the cyst wall resulting in increased risk for pneumothorax. (Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Authors: Paul Christiaan Johannesma, Arjan C. Houweling, Jan‐Hein T.M. Waesberghe, R.J. Jeroen A. Moorselaar, Theo M. Starink, Fred H. Menko, Pieter E. Postmus Tags: SCIENTIFIC LETTER Source Type: research

Forthcoming Meetings
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Tags: FORTHCOMING MEETINGS Source Type: research

Journal Statistics
(Source: Respirology)
Source: Respirology - October 9, 2014 Category: Respiratory Medicine Tags: JOURNAL STATISTICS Source Type: research

Glycomic Profiles of Ferret Respiratory Tissues [Glycobiology and Extracellular Matrices]
The initial recognition between influenza virus and the host cell is mediated by interactions between the viral surface protein hemagglutinin and sialic acid-terminated glycoconjugates on the host cell surface. The sialic acid residues can be linked to the adjacent monosaccharide by α2–3- or α2–6-type glycosidic bonds. It is this linkage difference that primarily defines the species barrier of the influenza virus infection with α2–3 binding being associated with avian influenza viruses and α2–6 binding being associated with human strains. The ferret has been extensively used as an animal model to study the tran...
Source: Journal of Biological Chemistry - October 9, 2014 Category: Chemistry Authors: Jia, N., Barclay, W. S., Roberts, K., Yen, H.-L., Chan, R. W. Y., Lam, A. K. Y., Air, G., Peiris, J. S. M., Dell, A., Nicholls, J. M., Haslam, S. M. Tags: Glycobiology and Extracellular Matrices Source Type: research

Antibiotics for bronchiolitis in children under two years of age.
CONCLUSIONS: This review did not find sufficient evidence to support the use of antibiotics for bronchiolitis, although research may be justified to identify a subgroup of patients who may benefit from antibiotics. Further research may be better focused on determining the reasons that clinicians use antibiotics so readily for bronchiolitis, how to reduce their use and how to reduce clinician anxiety about not using antibiotics. PMID: 25300167 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 9, 2014 Category: Journals (General) Authors: Farley R, Spurling GK, Eriksson L, Del Mar CB Tags: Cochrane Database Syst Rev Source Type: research

Antibiotics for community-acquired pneumonia in adult outpatients.
CONCLUSIONS: Available evidence from recent RCTs is insufficient to make new evidence-based recommendations for the choice of antibiotic to be used for the treatment of CAP in outpatient settings. Pooling of study data was limited by the very low number of studies assessing the same antibiotic pairs. Individual study results do not reveal significant differences in efficacy between various antibiotics and antibiotic groups. However, two studies did find significantly more adverse events with use of cethromycin as compared to clarithromycin and nemonoxacin when compared to levofloxacin. Multi-drug comparisons using similar ...
Source: Cochrane Database of Systematic Reviews - October 9, 2014 Category: Journals (General) Authors: Pakhale S, Mulpuru S, Verheij TJ, Kochen MM, Rohde GG, Bjerre LM Tags: Cochrane Database Syst Rev Source Type: research

Four-dimensional, multiphase, steady-state imaging with contrast enhancement (MUSIC) in the heart: A feasibility study in children.
CONCLUSION: The 4D MUSIC technique may represent a new paradigm in MR evaluation of cardiovascular anatomy and function in children with complex congenital heart disease. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. PMID: 25302932 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - October 9, 2014 Category: Radiology Authors: Han F, Rapacchi S, Khan S, Ayad I, Salusky I, Gabriel S, Plotnik A, Paul Finn J, Hu P Tags: Magn Reson Med Source Type: research

Organic Changes in the Central Nervous System in Children on Chronic Inhaled Corticosteroid Therapy.
In conclusion, patients receiving chronic inhaled corticosteroids had small subcortical hyperintense foci and features of mild supratentorial cortical atrophy. These findings suggest that ICS exposure may be associated with the development of organic changes in CNS. Further studies are needed to detail the extent of brain ICS-induced changes in children on chronic inhalative corticosteroid therapy as well as delayed impact of these changes on psychomotor functioning in adulthood. PMID: 25298261 [PubMed - as supplied by publisher] (Source: Adv Data)
Source: Adv Data - October 9, 2014 Category: Epidemiology Authors: Michalczuk M, Sybilski AJ, Piliszek A, Walecki J Tags: Adv Exp Med Biol Source Type: research

Virgibacillus oceani sp. nov. isolated from the Western Pacific.
Abstract A Gram-positive, moderately halophilic, motile, aerobic, endospore-forming, rod-shaped bacterium, strain MY11 (T), was isolated from a sediment sample collected from the Western Pacific. This isolate grew in the presence of 0.5-18 % (w/v) NaCl and at pH 6.0-10.0 and 15-45 °C; optimum growth was observed with 3.5 % (w/v) NaCl and at pH8.0-9.0 and 35-37 °C. Strain MY11(T) had MK-7 as the predominant respiratory quinone and anteiso-C15:0 and anteiso-C17:0 as major fatty acids. Major polar lipids were diphosphatidylglycerol and phosphatidylglycerol. The DNA G+C content was 34.2 mol%. Phylogenetic analysis ba...
Source: International Journal of Systematic and Evolutionary Microbiology - October 9, 2014 Category: Microbiology Authors: Yin X, Yang Y, Wang S, Zhang G Tags: Int J Syst Evol Microbiol Source Type: research

Spongiibacterium pacificum sp. nov., isolated from seawater of South Pacific Gyre and emended description of the genus Spongiibacterium.
Abstract A Gram-stain-negative, strictly aerobic, non-flagellated, non-gliding, oxidase-positive and rod shaped yellow-pigmented bacterium, designated strain SW169T, was isolated from surface seawater sample collected from the South Pacific Gyre (27°55' S 123°10' W) during the Integrated Ocean Drilling Program (IODP) Expedition 329. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain SW169T belonged to the genus Spongiibacterium and showed the highest 16S rRNA gene sequence similarity with Spongiibacterium flavum A11T (95.9%). It showed 93.2-94.8% 16S rRNA gene sequence similarity with re...
Source: International Journal of Systematic and Evolutionary Microbiology - October 9, 2014 Category: Microbiology Authors: Gao X, Zhang Z, Dai X, Zhang XH Tags: Int J Syst Evol Microbiol Source Type: research

ECMO support for right main bronchial disruption in multiple trauma patient with brain injury-a case report and literature review.
Abstract Extracorporeal membrane oxygenation (ECMO) may offer life-saving treatment in severe pulmonary contusion or acute respiratory distress syndrome when conventional treatments have failed. However, because of the bleeding risk of systemic anticoagulation, ECMO should be performed only as a last resort in multiple trauma victims. Here, we report ECMO as a bridge for right main bronchus reconstruction and recovery of traumatic wet lung in a 31-year-old male multi-trauma patient with right main bronchial disruption, bilateral pulmonary contusion, cerebral contusion and long bone fracture. The patient was dischar...
Source: Perfusion - October 9, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Zhou R, Liu B, Lin K, Wang R, Qin Z, Liao R, Qiu Y Tags: Perfusion Source Type: research

Current concept of transcatheter closure of atrial septal defect in adults.
Abstract After the introduction of catheter intervention for atrial septal defect (ASD) in the pediatric population, therapeutic advantages of this less invasive procedure were focused on adult through geriatric populations. The most valuable clinical benefits of this procedure are the significant improvement of symptoms and daily activities, which result from the closure of left to right shunt without thoracotomy and cardiopulmonary bypass surgery. These benefits contribute to increase the number of adult patients of this condition who have hesitated over surgical closure. In terms of technical point of view for c...
Source: Journal of Cardiology - October 9, 2014 Category: Cardiology Authors: Akagi T Tags: J Cardiol Source Type: research

Frequency of viral etiology in symptomatic adult upper respiratory tract infections.
CONCLUSION: Results presented in this report suggest that respiratory viral infections are largely under diagnosed in immunocompetent adults. Although the majority of young adult infections are not life-threatening they may impose a significant burden, especially in developing countries since these individuals represent a large fraction of the working force. PMID: 25307684 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - October 9, 2014 Category: Infectious Diseases Authors: da Silva RC, da Silva Mendes G, Rojas MA, Amorim AR, Couceiro JN, Lupi O, Elabras J, Pires G, Valle S, Santos N Tags: Braz J Infect Dis Source Type: research

CT findings of probable UIP have a high predictive value for histologic UIP.
Conclusions:Probable CT UIP is associated with a higher rate of histologic UIP than indeterminate CT UIP suggesting that they are distinct groups and should not be combined into a single CT category as currently recommended by guidelines. CT and microscopic honeycombing may be dissimilar entities. The T allele at rs35705950 predicts a UIP diagnosis by both chest CT and histology. Background: The current UIP/IPF CT classification system excludes probable UIP as a diagnostic category. We sought to determine the predictive effect of probable CT UIP on histology, and to determine the effect of the promoter polymorphism in ...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Chung JH, Chawla A, Peljto AL, Cool C, Groshong SD, Talbert JL, McKean D, Brown KK, Fingerlin TE, Schwarz MI, Schwartz DA, Lynch DA Tags: Chest Source Type: research

Non-Invasive Positive Pressure Ventilation Following Esophagectomy: Safety Demonstrated in a Pig Model.
Conclusions:Our pig model suggests that an esophagectomy anastomosis can tolerate a considerably higher pressure than is transmitted to the esophagus during NPPV. NPPV may be a safe alternative to ET after esophagectomy. Background: Respiratory complications occur in 20-65% of esophagectomy patients. While non-invasive positive pressure ventilation (NPPV) is associated with fewer complications than endotracheal intubation (ET), it is relatively contraindicated after esophagectomy due to potential injury to the anastomosis. We created an ex vivo and in vivo pig model to determine the pressure tolerance of an esophagecto...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Raman V, MacGlaflin CE, Erkmen CP Tags: Chest Source Type: research

Pre-Intubation application of oral chlorhexidine does not provide additional benefit in prevention of early onset ventilator-associated pneumonia.
ConclusionsAlthough it is feasible to deliver CHX prior to intubation (including emergent or urgent intubation), the results suggest that pre-intubation CHX may be inconsequential when the ventilator bundle, including daily oral CHX, is in place. During the pre-intubation period, providers should focus their attention on other critical activities.Clinical Trial NCT00893763. Introduction: Daily application of oral chlorhexidine gluconate (CHX) following intubation to reduce risk of ventilator-associated pneumonia (VAP) is now standard of care in many intensive care units. This randomized ...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Munro CL, Grap MJ, Sessler CN, Elswick RK, Mangar D, Karlnoski-Everall R, Cairns P Tags: Chest Source Type: research

Prognostic Accuracy of Clinical Prediction Rules for Early Post-Pulmonary Embolism All-Cause Mortality: A Bivariate Meta-Analysis.
Conclusions:Numerous CPRs for prognosticating early mortality in aPE patients are available, but not all demonstrate the high sensitivity needed to reassure clinicians. Background: Studies suggest outpatient treatment or early discharge of acute pulmonary embolism (aPE) is reasonable for those deemed to be at low-risk of early mortality. We sought to determine clinical prediction rule (CPR) accuracy for identifying aPE patients at low-risk for mortality. Methods: We performed a literature search of Medline and Embase from January 2000-March 2014, along with a manual search of references. We included studies derivin...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Kohn CG, Mearns EL, Parker MW, Hernandez AV, Coleman CI Tags: Chest Source Type: research

Ventilation-perfusion distribution abnormalities in morbidly obese subjects before and after bariatric surgery.
CONCLUSIONS.Morbid obesity is associated with mild-to-moderate shunt and VA/Q imbalance. These abnormalities are reduced after BS. BACKGROUND.: Obesity is a global and growing public health problem. Bariatric surgery (BS) is indicated in patients with morbid obesity. The effects of morbid obesity and BS upon ventilation-perfusion (VA/Q) ratio distributions using the multiple inert gas elimination technique have never been explored before. METHODS.: We compared respiratory and inert gas (VA/Q ratio distributions) pulmonary gas exchange, both breathing ambient air and 100% oxygen, in 19 morbidly obese women (body mas...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Rivas E, Arismendi E, Agustí A, Sanchez M, Delgado S, Gistau C, Wagner PD, Rodriguez-Roisin R Tags: Chest Source Type: research

Bardet Biedl Syndrome: Motile Ciliary Phenotype.
In conclusion motile ciliary structure and function is essentially normal in patients with BBS. Cilia line the surface of the respiratory tract and beat in a coordinated wave to protect the lungs against infection. Bardet Biedl Syndrome (BBS) is rare condition attributed to cilia dysfunction. Murine models of BBS suggest a respiratory phenotype, however, no reports have studied the translation of these findings in patients. We assessed clinical symptoms of motile cilia dysfunction and histology of ciliated respiratory epithelium in patients with BBS. We report an increased prevalence of neonatal respiratory dis...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Shoemark A, Dixon M, Beales P, Hogg C Tags: Chest Source Type: research

Development of a novel multilayered presentation format for clinical practice guidelines.
Conclusion:We have developed an electronic multilayered CPG format that enhances the usability of CPGs for front-line clinicians. We have implemented the format in electronic guideline tools which guideline organizations can now use when authoring and publishing their guidelines. Background: Bridging the gap between clinical research and everyday healthcare practice requires effective communication strategies. To address current shortcomings in conveying practice recommendations and supporting evidence, we are creating and testing presentation formats for clinical practice guidelines (CPGs). Methods: We carried out...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Kristiansen A, Brandt L, Alonso-Coello P, Agoritsas T, Akl EA, Conboy T, Elbarbary M, Ferwana M, Medani W, Murad MH, Rigau D, Rosenbaum S, Spencer FA, Treweek S, Guyatt G, Vandvik PO Tags: Chest Source Type: research

Choosing Wisely in Critical Care Maximizing Value in the Intensive Care Unit.
Abstract Abstract: Overuse of medical tests and treatments wastes health care resources and leads to unnecessary complications, while underuse results in delayed or missed diagnoses and treatment opportunities. Such problems are well recognized and there have been multiple attempts to correct inappropriate diagnostic testing and treatment over the past several decades. However, sustainable solutions have proven to be elusive. PMID: 25317583 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Angus DC, Deutschman CS, Hall JB, Wilson KC, Munro CL, Hill NS Tags: Chest Source Type: research

Pulmonary arterial hypertension in the southern hemisphere: results from a registry of incident Brazilian cases.
Conclusions:The distribution of PAH etiologies and the baseline characteristics in our registry clearly differ from the previously published European and USA-based registries. These differences highlight the importance of regional registries and also raise questions regarding the need to better account for such differences in future clinical trials. Background: Pulmonary arterial hypertension (PAH) is a rare and ultimately fatal disorder of the pulmonary vasculature. There is increasing interest in the worldwide characteristics of PAH patients, although data coming from the southern hemisphere remain scarce. The object...
Source: Chest - October 9, 2014 Category: Respiratory Medicine Authors: Alves JL, Gavilanes F, Jardim C, Fernandes CJ, Morinaga LT, Dias B, Hoette S, Humbert M, Souza R Tags: Chest Source Type: research

Childhood consequences of maternal obesity and excessive weight gain during pregnancy
Abstract Obesity is a major public health concern. In western countries, the prevalence of obesity in pregnant women has strongly increased, with reported prevalence rates reaching 30%. Also, up to 40% of women gain an excessive amount of weight during pregnancy. Recent observational studies and meta‐analyses strongly suggest long‐term impact of maternal obesity and excessive weight gain during pregnancy on adiposity, cardiovascular and respiratory related health outcomes in their children. These observations suggest that maternal adiposity during pregnancy may program common health problems in the offspring. Currently...
Source: Acta Obstetricia et Gynecologica Scandinavica - October 9, 2014 Category: OBGYN Authors: Romy Gaillard, Janine F. Felix, Liesbeth Duijts, Vincent W.V. Jaddoe Tags: Commentary Source Type: research

Trichomonas vaginalis Induces Cytopathic Effect on Human Lung Alveolar Basal Carcinoma Epithelial Cell Line A549.
Abstract Trichomonas vaginalis, the causative agent of trichomoniasis is generally known to inhabit the genitourinary tract. However, several case reports with supporting molecular and immunological identifications have documented its occurrence in the respiratory tract of neonates and adults. In addition, the reports have documented that its occurrence is associated with respiratory failures. The medical significance or consequence of this association is unclear. Thus, to establish the possible outcome from the interaction of T. vaginalis with lung cells, the cytopathic effects of the parasites were evaluated usin...
Source: Experimental Parasitology - October 9, 2014 Category: Parasitology Authors: Salvador-Membreve DM, Jacinto SD, Rivera WL Tags: Exp Parasitol Source Type: research

Whole genome response in guinea pigs infected with the high virulence strain TT372
In this study we conducted a microarray-based whole genomic analysis of gene expression in the lungs after exposure of guinea pigs to a low dose aerosol of the Atypical Beijing Western Cape TT372 strain of Mycobacterium tuberculosis, after harvesting lung tissues three weeks after infection at a time that effector immunity is starting to peak. The infection resulted in a very large up-regulation of multiple genes at this time, particularly in the context of a “chemokine storm” in the lungs. Overall gene expression was considerably reduced in animals that had been vaccinated with BCG two months earlier, but in both case...
Source: Tuberculosis - October 9, 2014 Category: Respiratory Medicine Authors: Mohamed Aiyaz, Chand Bipin, Vinay Pantulwar, Raja Mugasimangalam, Crystal A. Shanley, Diane J. Ordway, Ian M. Orme Tags: Immunological aspects Source Type: research

Is infection with hypermutable clinically significant?
Hypermutable Pseudomonas aeruginosa (HPA) with high mutation rate due to defects in the DNA mismatch repair genes are frequently isolated in the sputum of cystic fibrosis (CF) patients. These isolates tend to be multidrug resistant and may be better adapted to the CF lung environment. However, the clinical significance of this infection has not been determined. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 9, 2014 Category: Respiratory Medicine Authors: Adi Auerbach, Eitan Kerem, Marc Victor Assous, Elie Picard, Maskit Bar-Meir Tags: Original Article Source Type: research

Coccidioidomycosis of the Genitourinary Tract: A Case Report and Discussion
We report a case of genitourinary coccidioidomycosis and discussion of genitourinary disease with coccidioidomycosis. (Source: Urology)
Source: Urology - October 9, 2014 Category: Urology & Nephrology Authors: Arthi Satyanarayan, Stephen Klotz, Lucy Han, Richard Sobonya, Tirdad T. Zangeneh Tags: Infectious Diseases Source Type: research

Accuracy of pulmonary auscultation to detect abnormal respiratory mechanics: A cross-sectional diagnostic study
Pulmonary auscultation is a method used in clinical practice for the evaluation and detection of abnormalities relating to the respiratory system. This method has limitations, as it depends on the experience and hearing acuity of the examiner to determine adventitious sounds. In this context, it’s important to analyze whether there is a correlation between auscultation of lung sounds and the behavior of the respiratory mechanical properties of the respiratory system in patients with immediate postoperative cardiac surgery. (Source: Medical Hypotheses)
Source: Medical Hypotheses - October 9, 2014 Category: Biomedical Science Authors: Glaciele Nascimento Xavier, Antonio Carlos Magalhães Duarte, César Augusto Melo-Silva, Carlos Eduardo Ventura Gaio dos Santos, Veronica Moreira Amado Source Type: research

Detection of a novel avian influenza A (H7N9) virus in humans by multiplex one-step real-time RT-PCR assay
Conclusions: These results demonstrate that the multiplex assay detected the novel avian H7N9 virus with high specificity and sensitivity, which is essential for the early diagnosis and treatment of infected patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - October 8, 2014 Category: Infectious Diseases Authors: Jian FanDavid CuiSiuying LauGuoliang XieXichao GuoShufa ZhengXiaofeng HuangShigui YangXianzhi YangZhaoxia HuoFei YuJianzhou LouLi TianXuefen LiYuejiao DongQiaoyun ZhuYu Chen Source Type: research

Pathogenesis of Middle East respiratory syndrome coronavirus
This article reviews the clinical and pathological available on MERS and compares it to SARS. Most importantly, chest radiographs and imaging results of patients with MERS show features that resemble the findings of organizing pneumonia, different from the lesions in SARS patients, which show fibrocellular intra‐alveolar organization with a bronchiolitis obliterans organizing pneumonia‐like pattern. These findings are in line with differences in the induction of cytopathological changes, induction of host gene responses and sensitivity to the antiviral effect of interferons in vitro when comparing both MERS‐CoV and S...
Source: The Journal of Pathology - October 8, 2014 Category: Pathology Authors: Judith M.A. van den Brand, Saskia L. Smits, Bart L. Haagmans Tags: Invited Review Source Type: research

Exchange transfusion can be life-saving in severe propanil poisoning: a case report
Conclusion: Propanil has potential to produce severe life threatening clinical manifestations, despite categorization as a herbicide with low toxicity. In cases of severe poisoning, exchange transfusion may be life saving. Since methylene blue, intensive care and exchange transfusion facilities are also not readily available in local hospitals, which frequently encounter cases of severe Propanil poisoning, early transfer of patients to tertiary care hospitals should be considered. Exchange transfusion may be helpful even in late stages in patients with severe poisoning. (Source: BMC Research Notes)
Source: BMC Research Notes - October 8, 2014 Category: Research Authors: Priyanga RanasingheShani DilrukshiInoshi AtukoralaPrasad KatulandaAriaranee Gnanathasan Source Type: research

Impact of ozone exposure on the response to glucocorticoid in a mouse model of asthma: involvements of p38 MAPK and MKP-1
Conclusions: The glucocorticoids insensitivity elicited by ozone exposure on current asthma model may involve the enhanced phosphorylation of p38 MAPK and disturbed expression of MKP-1. (Source: Respiratory Research)
Source: Respiratory Research - October 8, 2014 Category: Respiratory Medicine Authors: Aihua BaoFeng LiMin ZhangYuqing ChenPengyu ZhangXin Zhou Source Type: research

Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension
Conclusions: There was an increase in the protein and mRNA expression of hexokinase-1 (HK1) three and four weeks after the injection of monocrotaline in the right ventricle, intervention of HK1 may be amenable to therapeutic intervention. (Source: Respiratory Research)
Source: Respiratory Research - October 8, 2014 Category: Respiratory Medicine Authors: Wei-hua ZhangMei-hong QiuXiao-jian WangKai SunYang ZhengZhi-cheng Jing Source Type: research

Occupational asthma to fish
We report the evaluation of a 31-year-old worker who developed occupational asthma following exposure to sole fish (Yellowfin sole). She had been working in a restaurant's kitchen, cooking different types of products including fish, most often sole. In the last 3 years, this worker had developed erythema and pruritus of the hands and forearms while she was manipulating fishes such as sole. In the month before being assessed at our Centre, she had increasing symptoms of dyspnoea, chest tightness and wheezing when she was exposed to cooking fumes from sole fish. She also reported symptoms suggestive of localised angioed...
Source: Occupational and Environmental Medicine - October 8, 2014 Category: Occupational Health Authors: Boulet, L.-P., Laberge, F. Tags: PostScript Source Type: research

Genitourinary health in a population‐based cohort of males with Duchenne and Becker muscular dystrophies
Discussion: These findings highlight increased awareness of GU health and multidisciplinary care of DBMD patients. © 2014 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - October 8, 2014 Category: Internal Medicine Authors: Yong Zhu, Paul A. Romitti, Kristin M. Caspers Conway, Sunkyung Kim, Ying Zhang, Michele Yang, Katherine D. Mathews, Tags: Research Article Source Type: research

Stenotrophomonas maltophilia Infection Among Young Children in a Cardiac Intensive Care Unit: A Single Institution Experience
Abstract Stenotrophomonas maltophilia can present as bacteremia, respiratory tract infection, urinary tract infection, soft tissue and wound infections, bone and joint infections, meningitis, and endocarditis especially in immunosuppressed patients and those with underlying medical conditions. The incidence and impact of S. maltophilia in young children with heart disease are poorly defined. A single center retrospective observational study was conducted in infants <180 days of age with positive S. maltophilia cultures over a period of 5 years. The overall incidence for S. maltophilia infection was...
Source: Mammalian Genome - October 8, 2014 Category: Genetics & Stem Cells Source Type: research

Evaluation of a spatially resolved forest fire smoke model for population-based epidemiologic exposure assessment
enderson (Source: Journal of Exposure Science and Environmental Epidemiology)
Source: Journal of Exposure Science and Environmental Epidemiology - October 8, 2014 Category: Epidemiology Authors: Jiayun YaoJeff EyamieSarah B Henderson Tags: forest fire smoke particulate matter respiratory effects cardiovascular effects modeling epidemiology Source Type: research

Inhibitors of PDE4, but Not PDE3, Increase β2-agonist-induced Expression of Anti-inflammatory MKP-1 in Airway Smooth Muscle Cells.
Abstract β2-agonists are principally used in asthma to provide bronchodilation, however they also have anti-inflammatory properties due, in part, to their ability to upregulate mitogen-activated protein kinase phosphatase 1 (MKP-1) in a cAMP-dependent manner. Phosphodiesterases (PDEs) are attractive targets for potentiating the anti-inflammatory response. There are 11 subfamilies of PDE enzymes, among these, inhibition of PDE3 and PDE4 are the main targets for airway smooth muscle (ASM). PDE enzymes are important intracellular regulators that catalyze the breakdown of cAMP and/or cGMP to their inactive forms. Give...
Source: American Journal of Respiratory Cell and Molecular Biology - October 8, 2014 Category: Molecular Biology Authors: Patel BS, Prabhala P, Oliver BG, Ammit AJ Tags: Am J Respir Cell Mol Biol Source Type: research

Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation.
Abstract Acute respiratory distress syndrome (ARDS) is a common and oftentimes fatal inflammatory lung condition without effective targeted therapies. Regulatory T cells (Tregs) resolve lung inflammation, but mechanisms that enhance Tregs to promote resolution of established damage remain unknown. DNA demethylation at the forkhead box protein 3 (Foxp3) locus and other key Treg loci typify the Treg lineage. To test how dynamic DNA demethylation affects lung injury resolution, we administered the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine (DAC) to wild type mice beginning 24 hours after intratracheal lipo...
Source: American Journal of Respiratory Cell and Molecular Biology - October 8, 2014 Category: Molecular Biology Authors: Singer BD, Mock JR, Aggarwal NR, Garibaldi BT, Sidhaye VK, Florez MA, Chau E, Gibbs KW, Mandke P, Tripathi A, Yegnasubramanian S, King LS, D'Alessio FR Tags: Am J Respir Cell Mol Biol Source Type: research

The thermic effect of sugar-free Red Bull: Do the non-caffeine bioactive ingredients in energy drinks play a role?
CONCLUSIONS: sfRB enhanced thermogenesis and marginally shifted RQ to favor carbohydrate oxidation. The stimulatory effects of sfRB on REE are mimicked by water + caffeine, indicating that the auxiliary ingredients do not influence this thermic effect. The metabolic effects of sfRB are primarily due to caffeine alone. PMID: 25294090 [PubMed - as supplied by publisher] (Source: Obesity)
Source: Obesity - October 8, 2014 Category: Eating Disorders and Weight Management Authors: Miles-Chan JL, Charrière N, Grasser EK, Montani JP, Dulloo AG Tags: Obesity (Silver Spring) Source Type: research

Obstructive Sleep Apnea During REM Sleep and Hypertension: Results of the Wisconsin Sleep Cohort.
Conclusions: Our findings indicate that REM OSA is cross-sectionally and longitudinally associated with hypertension. This is clinically relevant since treatment of OSA is often limited to the first half of the sleep period leaving most of REM sleep untreated. PMID: 25295854 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 8, 2014 Category: Respiratory Medicine Authors: Mokhlesi B, Finn LA, Hagen EW, Young T, Hla KM, Van Cauter E, Peppard PE Tags: Am J Respir Crit Care Med Source Type: research