Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

The role of inspiratory pressures in determining the flow rates though dry powder inhalers a review.
THE ROLE OF INSPIRATORY PRESSURES IN DETERMINING THE FLOW RATES THOUGH DRY POWDER INHALERS A REVIEW. Curr Pharm Des. 2015 Aug 19; Authors: Clark AR Abstract Dry powder inhalers are one of the most popular devices for delivering medication directly to the lungs of patients. Both for local action and when using the lungs as a portal of entry into the systemic circulation. Dry powder inhalers rely on the patient's inspiratory effort to supply the energy for the device to effectively deliver medication. In this respect they are limited by the airway pressures that a patient can generate with their respirat...
Source: Current Pharmaceutical Design - August 19, 2015 Category: Drugs & Pharmacology Authors: Clark AR Tags: Curr Pharm Des Source Type: research

Dry Powder Formulation of Plasmid DNA and siRNA for Inhalation.
Abstract Nucleic acid therapeutics has huge potential for the treatment of a wide range of diseases including respiratory diseases. Plasmid DNA (pDNA) and small interfering RNA (siRNA) are the two most widely investigated nucleic acids for therapeutic development. However, efficient and safe delivery of nucleic acids is still a major hurdle in translating nucleic acid therapy into clinical practice. For the treatment of respiratory diseases, administration via inhalation is the most direct and effective way to deliver therapeutic nucleic acids to the lungs. Although liquid aerosol formulation is investigated in mos...
Source: Current Pharmaceutical Design - August 19, 2015 Category: Drugs & Pharmacology Authors: Chow MY, Lam JK Tags: Curr Pharm Des Source Type: research

Using multiple online databases to help identify microRNAs regulating the airway epithelial cell response to a virus‐like stimulus
ConclusionsOur study demonstrates the value of using multiple online databases to identify candidate regulatory microRNA and provides the first evidence that in an allergic environment, microRNA may be important in altering the pro‐inflammatory and anti‐viral responses of human AEC during exacerbations of asthma. (Source: Respirology)
Source: Respirology - August 19, 2015 Category: Respiratory Medicine Authors: Cristan Herbert, Michelle Sebesfi, Qing‐Xiang Zeng, Brian G Oliver, Paul S Foster, Rakesh K Kumar Tags: Original Article Source Type: research

Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice.
Abstract Respiratory syncytial virus is a major cause of bronchiolitis in infants and pneumonia virus of mice (PVM) causes similar disease in mice. The impact of PVM infection in BALB/c and C57BL/6 neonates, and upon re-infection as elderly mice, was compared. As previously shown for adult mice, PVM caused more disease in BALB/c than in C57BL/6 neonates. After PVM-15 infection BALB/c neonates showed higher production of inflammatory mediators, more influx of plasmacytoid dendritic cells and higher IFN-α expression, and more IgA in the lungs than C57BL/6 neonates. After re-infection as elderly, BALB/c mice develope...
Source: Virology - August 19, 2015 Category: Virology Authors: Shrivastava P, Atanley E, Sarkar I, Watkiss E, Gomis S, van Drunen Littel-van den Hurk S Tags: Virology Source Type: research

Respiratory syncytial virus nonstructural proteins 1 and 2 are crucial pathogenic factors that modulate interferon signaling and Treg cell distribution in mice.
Abstract Respiratory syncytial virus (RSV) nonstructural (NS) proteins 1 and 2 have multiple functions in suppressing the innate immune response and modulating T helper cell subset differentiation. However, little is known about the roles of NS proteins as independent virulence factors. We investigated the effects of recombinant NS1- and NS2-expressing plasmids on the pathogenesis of murine respiratory tissues and splenetic Foxp3+ regulatory T (Treg) cell distribution. Both NS proteins caused weight loss in mice, and NS2 transfection resulted in a persistent weight loss. NS1 dramatically suppressed the induction of...
Source: Virology - August 19, 2015 Category: Virology Authors: Yang P, Zheng J, Wang S, Liu P, Xie M, Zhao D Tags: Virology Source Type: research

Resveratrol inhibits rhinovirus replication and expression of inflammatory mediators in nasal epithelia.
Abstract Human rhinoviruses (HRV), the cause of common colds, are the most frequent precipitants of acute exacerbation of asthma and chronic obstructive pulmonary disease, as well as causes of other serious respiratory diseases. No vaccine or antiviral agents are available for the prevention or treatment of HRV infection. Resveratrol exerts antiviral effect against different DNA and RNA viruses. The antiviral effect of a new resveratrol formulation containing carboxymethylated glucan was analyzed in H1HeLa cell monolayers and ex vivo nasal epithelia infected with HRV-16. Virus yield was evaluated by plaque assay an...
Source: Antiviral Research - August 19, 2015 Category: Virology Authors: Mastromarino P, Capobianco D, Cannata F, Nardis C, Mattia E, De Leo A, Restignoli R, Francioso A, Mosca L Tags: Antiviral Res Source Type: research

The role of impulse oscillometry in detecting airway dysfunction in athletes
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Relationships among obesity, physical activity and sedentary behavior in young adolescents with and without lifetime asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Benefits of completing pulmonary rehabilitation in patients with asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Correlation of TSLP, IL-33, and CD4 + CD25 + FOXP3 + T regulatory (Treg) in pediatric asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Prevalence of over-/misdiagnosis of asthma in patients referred to an allergy clinic
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Self-reported physician-diagnosed asthma among Swedish adolescent, adult and former elite endurance athletes
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Exhaled nitric oxide as a better diagnostic indicator for evaluating wheeze and airway hyperresponsiveness in preschool children
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Salmeterol/fluticasone through breath-actuated inhaler versus pMDI: a randomized, double-blind, 12 weeks study
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

A snapshot of pharmacist attitudes and behaviors surrounding the management of pediatric asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Caregiver education to promote appropriate use of preventive asthma medications: what is happening in primary care?
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Postural stability in school-age children with mild bronchial asthma disease (a pilot study)
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Fluticasone furoate (FF)/vilanterol (100/25 mcg or 200/25 mcg) or FF (100 mcg) in persistent asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Influenza‐associated mortality in Thailand, 2006‐2011
This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - August 18, 2015 Category: Virology Authors: Suchunya Aungkulanon Tags: Original Article Source Type: research

Upstream Disaster Management to Support People Experiencing Homelessness
Conclusions People who are homeless or experiencing housing insecurity face tremendous challenges in day-to-day living; basic needs must be prioritized over disaster preparedness. Upstream strategies that address social determinants of health can contribute to adaptive capacity across individual, organizational and community levels. Creating opportunities for inter-organizational collaboration between all levels of government and organizations providing front line supports for people who are chronically or episodically homeless is an important investment to enhance adaptive capacity. Continuity of operations planning for c...
Source: PLOS Currents Disasters - August 18, 2015 Category: Global & Universal Authors: Tracey O'Sullivan Source Type: research

Analysis of influenza and parainfluenza respiratory infection in a private tertiary hospital in São Paulo, Brazil
No description available (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - August 18, 2015 Category: Epidemiology Authors: Frederico P LomarCarmen SV BarbasGustavo FJ de MatosHumberto B BogossianTelma Anunes Source Type: research

Acute Effects of a Respiratory Sprint-Interval Session on Muscle Contractility
Conclusions: Despite different work history, RMSIT appears to place a metabolic load on respiratory muscles similarly to RMET and could therefore be considered a time-saving and safe training alternative. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - August 18, 2015 Category: Sports Medicine Tags: Applied Sciences Source Type: research

Exercise Intensity Thresholds: Identifying the Boundaries of Sustainable Performance
Conclusions: Although the standard methods for determination of CP, RCP, MLSS, and [HHb]BP are different, these indices occur at the same V˙O2p, suggesting that i) they may manifest as a result of similar physiological phenomenon and ii) each provides a valid delineation between tolerable and intolerable constant-power exercise. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - August 18, 2015 Category: Sports Medicine Tags: Applied Sciences Source Type: research

Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle
Conclusions: Collectively, 12 wk of RET resulted in qualitative and quantitative changes in skeletal muscle mitochondrial respiration. This adaptation was accompanied by modest changes in mitochondrial proteins and transcript expression. RET seems to be a means to augment the respiratory capacity and intrinsic function of skeletal muscle mitochondria. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - August 18, 2015 Category: Sports Medicine Tags: Applied Sciences Source Type: research

Pulmonary Function Test Abnormalities in Pediatric Inflammatory Bowel Disease
Conclusions: This study supports evidence that variable and fluctuating pulmonary involvement also occurs in pediatric IBD patients. Its clinical significance is unclear.Respiration (Source: Respiration)
Source: Respiration - August 18, 2015 Category: Respiratory Medicine Source Type: research

Characterization of naturally occurring airborne diacetyl concentrations associated with the preparation and consumption of unflavored coffee
Publication date: Available online 18 August 2015 Source:Toxicology Reports Author(s): Jennifer S. Pierce, Anders Abelmann, Jason T. Lotter, Comerford Chris, Keeton Kara, Brent L. Finley Diacetyl, a suspected cause of respiratory disorders in some food and flavorings manufacturing workers, is also a natural component of roasted coffee. We characterized diacetyl exposures that would plausibly occur in a small coffee shop during the preparation and consumption of unflavored coffee. Personal (long- and short-term) and area (long-term) samples were collected while a barista ground whole coffee beans, and brewed and pou...
Source: Toxicology Reports - August 18, 2015 Category: Toxicology Source Type: research

Middle East respiratory syndrome (MERS) in Asia: lessons gleaned from the South Korean outbreak
(Source: Transactions of the Royal Society of Tropical Medicine and Hygiene)
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - August 18, 2015 Category: Tropical Medicine Authors: Lim, P. L. Tags: EDITORIAL Source Type: research

Clinical and microbiological features of definite Mycobacterium gordonae pulmonary disease: the establishment of diagnostic criteria for low-virulence mycobacteria
Conclusion The time taken to detect a positive culture and subtype of the isolates could be used as the diagnostic criteria for definite M. gordonae pulmonary disease. (Source: Transactions of the Royal Society of Tropical Medicine and Hygiene)
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - August 18, 2015 Category: Tropical Medicine Authors: Morimoto, K., Kazumi, Y., Shiraishi, Y., Yoshiyama, T., Murase, Y., Ikushima, S., Kurashima, A., Kudoh, S., Goto, H., Maeda, S. Tags: ORIGINAL ARTICLES Source Type: research

Clinical Effects of a Longer Duration of Polymyxin B‐Immobilized Fiber Column Direct Hemoperfusion Therapy for Severe Sepsis and Septic Shock
Abstract Polymyxin B‐immobilized fiber column direct hemoperfusion (PMX‐DHP) therapy is widely used for the treatment of severe sepsis and septic shock, and is generally performed for 2 h. Although previous studies demonstrated the efficacy of PMX‐DHP therapy, it currently remains unclear whether its optimal duration is 2 h. This retrospective study analyzed 37 patients with septic shock who showed a poor clinical response to 2 h of PMX‐DHP, and underwent a longer duration of this therapy. The mean duration of PMX‐DHP therapy was 15.8 ± 7.9 h, and none of the patients developed adverse events, which ...
Source: Therapeutic Apheresis and Dialysis - August 18, 2015 Category: Hematology Authors: Chizuru Yamashita, Yoshitaka Hara, Naohide Kuriyama, Tomoyuki Nakamura, Osamu Nishida Tags: Original Article Source Type: research

The role of the Child Death Overview Panel in improving outcomes for children
Being involved in the death of a child can be one of the most distressing and challenging experiences we face as paediatricians; conversely it can also be incredibly satisfying and rewarding. It is however inevitable in whatever area we practise, and whatever our level of training. Whether it is withdrawal of care in a premature baby on the neonatal unit, an “expected” death of a child with complex needs at home, or an adolescent in cardio-respiratory arrest who does not survive, we will often question whether anything could have been done differently? Could the death have been prevented? What lessons can be learned? A...
Source: Paediatrics and Child Health - August 18, 2015 Category: Pediatrics Authors: Caroline Rodrick Tags: Personal practice Source Type: research

Reduced immune responses in chimeric mice engrafted with bone marrow cells from mice with airways inflammation
Conclusions Dendritic cells developing from bone marrow progenitors during airways inflammation are altered such that daughter cells have reduced antigen priming capabilities. (Source: Inflammation Research)
Source: Inflammation Research - August 18, 2015 Category: Research Source Type: research

False normal Lung Clearance Index in infants with cystic fibrosis due to software algorithms
ConclusionWe recommend the use of the manual modus for the analysis of MBW outcomes in infants in order to obtain more accurate results. This will allow appropriate use of infant lung function results for clinical and scientific purposes. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 18, 2015 Category: Respiratory Medicine Authors: Pinelopi Anagnostopoulou, Sophie Yammine, Anne Schmidt, Insa Korten, Elisabeth Kieninger, Ines Mack, Daniel Trachsel, Gaudenz Hafen, Alexander Moeller, Carmen Casaulta, Philipp Latzin Tags: Original Article: Cystic Fibrosis Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 18, 2015 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Dose-finding evaluation of once-daily treatment with olodaterol, a novel long-acting β 2 -agonist, in patients with asthma: results of a parallel-group study and a crossover study
Background: Olodaterol is a novel, inhaled long-acting β 2 -agonist (LABA) with >24-hour duration of action investigated in asthma and chronic obstructive pulmonary disease. Methods: Two multicentre studies examined the efficacy and safety of 4 weeks’ once-daily (QD) olodaterol (2, 5, 10 and 20 μg, with background inhaled corticosteroids) in patients with asthma. One randomised, double-blind, parallel-group study (1222.6; 296 patients) administered treatment in the morning. Pulmonary function tests (PFTs) were performed pre-dose (trough) and ≤3 hours post-dose (weeks 1 and 2), and ≤6 hours ...
Source: Respiratory Research - August 18, 2015 Category: Respiratory Medicine Authors: Paul O¿ByrneTony D¿UrzoEkkehard BeckMatja¿ Fle¿arMartina GahlemannLorna HartZuzana BlahovaRobert ToorawaKai-Michael Beeh Source Type: research

Vaccines to prevent pneumonia in children–a developing country perspective
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 18, 2015 Category: Respiratory Medicine Authors: Jacquie N. Oliwa, Ben J. Marais Source Type: research

Diagnostic Methods in Primary Ciliary Dyskinesia
Diagnosing primary ciliary dyskinesia is difficult. With no reference standard, a combination of tests is needed; most tests require expensive equipment and specialist scientists. We review the advances in diagnostic testing over the past hundred years, with emphasis on recent advances. We particularly focus on use of high-speed video analysis, transmission electron microscopy, nasal nitric oxide and genetic testing. We discuss the international efforts that are in place to advance the evidence base for diagnostic tests. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - August 18, 2015 Category: Respiratory Medicine Authors: Jane S Lucas, Tamara Paff, Patricia Goggin, Eric Haarman Source Type: research

The impact of birth weight on the level of lung function and lung function decline in the general adult population. The Inter99 study
Previous studies have reported an association between low birth weight and low adult lung function, but findings have not been consistent. The aim of this study was to investigate whether low birth weight is associated with both the level and the decline in adult lung function in general population. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 18, 2015 Category: Respiratory Medicine Authors: Sophie Baumann, Nina Skavlan Godtfredsen, Peter Lange, Charlotta Pisinger Source Type: research

All-case post-marketing surveillance of 1371 patients treated with pirfenidone for idiopathic pulmonary fibrosis
Conclusions This post-marketing surveillance in Japan showed that pirfenidone was generally well tolerated in patients with IPF, including those with severe lung function impairment. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 18, 2015 Category: Respiratory Medicine Source Type: research

Delay in the diagnosis of tuberculosis
Publication date: Available online 17 August 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M. Guimarães, O. Oliveira, C. Teixeira, A.R. Gaio, R. Duarte (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - August 18, 2015 Category: Respiratory Medicine Source Type: research

Comparison of Infrared Thermal Detection Systems for mass fever screening in a tropical healthcare setting
This study, conducted in Singapore, a tropical city, evaluates the accuracy of three different ITDS for fever detection compared with traditional oral thermometry and self-reporting in a clinical setting. (Source: Public Health)
Source: Public Health - August 18, 2015 Category: Global & Universal Authors: M.R. Tay, Y.L. Low, X. Zhao, A.R. Cook, V.J. Lee Tags: Original Research Source Type: research

In This Issue [This Week in PNAS]
Antibody against MERS Transmission EM of MERS-CoV. Image courtesy of National Institute of Allergy and Infectious Diseases. Middle East Respiratory Syndrome (MERS) is a severe infection of the lower respiratory tract caused by the MERS coronavirus (MERS-CoV), which has been responsible for over 1,300 human infections and 500 deaths since... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 18, 2015 Category: Science Tags: This Week in PNAS Source Type: research

Speed antibodies to counter emerging viruses [Microbiology]
The global population is continually at risk for the emergence or reemergence of deadly viruses. The Ebola virus epidemic of 2014–2015 involved a known virus emerging in a new area (1, 2). The Severe Acute Respiratory Syndrome outbreak in 2002–2003 involved a novel virus from a family previously only known... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 18, 2015 Category: Science Authors: Burton, D. R., Saphire, E. O. Tags: Commentary Source Type: research

Anti-MERS coronavirus human neutralizing antibody [Microbiology]
In this study,... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 18, 2015 Category: Science Authors: Corti, D., Zhao, J., Pedotti, M., Simonelli, L., Agnihothram, S., Fett, C., Fernandez-Rodriguez, B., Foglierini, M., Agatic, G., Vanzetta, F., Gopal, R., Langrish, C. J., Barrett, N. A., Sallusto, F., Baric, R. S., Varani, L., Zambon, M., Perlman, S., Lan Tags: Biological Sciences Source Type: research