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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Fas ligand-expressing lymphocytes enhance alveolar macrophage apoptosis in the resolution of acute pulmonary inflammation
Apoptosis of alveolar macrophages and their subsequent clearance by neighboring phagocytes are necessary steps in the resolution of acute pulmonary inflammation. We have recently identified that activation of the Fas death receptor on the cell surface of macrophages drives macrophage apoptosis. However, the source of the cognate ligand for Fas (FasL) responsible for induction of alveolar macrophage apoptosis is not defined. Given their known role in the resolution of inflammation and ability to induce macrophage apoptosis ex vivo, we hypothesized that T lymphocytes represented a critical source of FasL. To address this hyp...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2014 Category: Respiratory Medicine Authors: Kearns, M. T., Barthel, L., Bednarek, J. M., Yunt, Z. X., Henson, P. M., Janssen, W. J. Tags: ARTICLES Source Type: research

NOX2 protects against progressive lung injury and multiple organ dysfunction syndrome
Systemic inflammatory response syndrome (SIRS) is a common clinical condition in patients in intensive care units that can lead to complications, including multiple organ dysfunction syndrome (MODS). MODS carries a high mortality rate, and it is unclear why some patients resolve SIRS, whereas others develop MODS. Although oxidant stress has been implicated in the development of MODS, several recent studies have demonstrated a requirement for NADPH oxidase 2 (NOX2)-derived oxidants in limiting inflammation. We recently demonstrated that NOX2 protects against lung injury and mortality in a murine model of SIRS. In the presen...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2014 Category: Respiratory Medicine Authors: Whitmore, L. C., Goss, K. L., Newell, E. A., Hilkin, B. M., Hook, J. S., Moreland, J. G. Tags: ARTICLES Source Type: research

Mucociliary clearance and submucosal gland secretion in the ex vivo ferret trachea
In many species submucosal glands are an important source of tracheal mucus, but the extent to which mucociliary clearance (MCC) depends on gland secretion is unknown. To explore this relationship, we measured basal and agonist-stimulated MCC velocities in ex vivo tracheas from adult ferrets and compared the velocities with previously measured rates of ferret glandular mucus secretion (Cho HJ, Joo NS, Wine JJ. Am J Physiol Lung Cell Mol Physiol 299: L124–L136, 2010). Stimulated MCC velocities (mm/min, means ± SE for 10- to 35-min period poststimulation) were as follows: 1 μM carbachol: 19.1 ± 3.3 >...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2014 Category: Respiratory Medicine Authors: Jeong, J. H., Joo, N. S., Hwang, P. H., Wine, J. J. Tags: ARTICLES Source Type: research

Lung fibroblasts accelerate wound closure in human alveolar epithelial cells through hepatocyte growth factor/c-Met signaling
There are 190,600 cases of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) each year in the United States, and the incidence and mortality of ALI/ARDS increase dramatically with age. Patients with ALI/ARDS have alveolar epithelial injury, which may be worsened by high-pressure mechanical ventilation. Alveolar type II (ATII) cells are the progenitor cells for the alveolar epithelium and are required to reestablish the alveolar epithelium during the recovery process from ALI/ARDS. Lung fibroblasts (FBs) migrate and proliferate early after lung injury and likely are an important source of growth factors for e...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2014 Category: Respiratory Medicine Authors: Ito, Y., Correll, K., Schiel, J. A., Finigan, J. H., Prekeris, R., Mason, R. J. Tags: ARTICLES Source Type: research

An 11-nt sequence polymorphism at the 3'UTR of human SFTPA1 and SFTPA2 gene variants differentially affect gene expression levels and miRNA regulation in cell culture
Surfactant protein A (SP-A) plays a vital role in maintaining normal lung function and in host defense. Two genes encode SP-A in humans (SFTPA1, SFTPA2), and several gene variants have been identified for these. We have previously shown that sequence elements of SFTPA1 and SFTPA2 3' untranslated regions (UTRs) differentially affect translation efficiency in vitro. Polymorphisms at the 3'UTRs of mRNA variants may account for differential binding of miRNAs, a class of small noncoding RNAs that regulate gene expression. In this work, we generated 3'UTR reporter constructs of the SFTPA1 and SFTPA2 variants most frequently foun...
Source: AJP: Lung Cellular and Molecular Physiology - July 1, 2014 Category: Respiratory Medicine Authors: Silveyra, P., DiAngelo, S. L., Floros, J. Tags: ARTICLES Source Type: research

Effects of sex hormones on bronchial reactivity during the menstrual cycle
Conclusions: In conclusion, our data show that PC20FEV1.0 was decreased in the follicular phase of the menstrual cycle in about 30% of women and was associated with lower cAMP levels in sputum samples, which may contribute to bronchoconstriction. Our results also suggest a link between PMA and testosterone levels. However, whether these findings are of clinical significance in terms of the management of asthma or asthma worsening during the menstrual cycle needs further investigation. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 1, 2014 Category: Respiratory Medicine Authors: Maria MatteisFrancesca PolverinoGiuseppe SpazianoFiorentina RoviezzoCarlo SantorielloNikol SulloMaria BucciFrancesco RossiMario PolverinoCaroline OwenBruno D¿Agostino Source Type: research

Mindfulness meditation lowers muscle sympathetic nerve activity and blood pressure in African-American males with chronic kidney disease
Mindfulness meditation (MM) is a stress-reduction technique that may have real biological effects on hemodynamics but has never previously been tested in chronic kidney disease (CKD) patients. In addition, the mechanisms underlying the potential blood pressure (BP)-lowering effects of MM are unknown. We sought to determine whether MM acutely lowers BP in CKD patients, and whether these hemodynamic changes are mediated by a reduction in sympathetic nerve activity. In 15 hypertensive African-American (AA) males with CKD, we conducted a randomized, crossover study in which participants underwent 14 min of MM or 14 min of BP e...
Source: AJP: Regulatory, Integrative and Comparative Physiology - July 1, 2014 Category: Physiology Authors: Park, J., Lyles, R. H., Bauer-Wu, S. Tags: Neural Control Source Type: research

Effect of abdominal binding on respiratory mechanics during exercise in athletes with cervical spinal cord injury
We asked whether elastic binding of the abdomen influences respiratory mechanics during wheelchair propulsion in athletes with cervical spinal cord injury (SCI). Eight Paralympic wheelchair rugby players with motor-complete SCI (C5-C7) performed submaximal and maximal incremental exercise tests on a treadmill, both with and without abdominal binding. Measurements included pulmonary function, pressure-derived indices of respiratory mechanics, operating lung volumes, tidal flow-volume data, gas exchange, blood lactate, and symptoms. Residual volume and functional residual capacity were reduced with binding (77 ± 18 an...
Source: Journal of Applied Physiology - July 1, 2014 Category: Physiology Authors: West, C. R., Goosey-Tolfrey, V. L., Campbell, I. G., Romer, L. M. Tags: ARTICLES Source Type: research

Both linoleic and {alpha}-linolenic acid prevent insulin resistance but have divergent impacts on skeletal muscle mitochondrial bioenergetics in obese Zucker rats
The therapeutic use of polyunsaturated fatty acids (PUFA) in preserving insulin sensitivity has gained interest in recent decades; however, the roles of linoleic acid (LA) and α-linolenic acid (ALA) remain poorly understood. We investigated the efficacy of diets enriched with either LA or ALA on attenuating the development of insulin resistance (IR) in obesity. Following a 12-wk intervention, LA and ALA both prevented the shift toward an IR phenotype and maintained muscle-specific insulin sensitivity otherwise lost in obese control animals. The beneficial effects of ALA were independent of changes in skeletal muscle ...
Source: AJP: Endocrinology and Metabolism - July 1, 2014 Category: Endocrinology Authors: Matravadia, S., Herbst, E. A. F., Jain, S. S., Mutch, D. M., Holloway, G. P. Tags: Articles Source Type: research

Clinical implications of initial peripheral eosinophilia in acute eosinophilic pneumonia
ConclusionsInitial PEC may be related to a milder disease status on admission, compared with normal PEC in patients with AEP. This may help to stratify disease severity in AEP. (Source: Respirology)
Source: Respirology - July 1, 2014 Category: Respiratory Medicine Authors: Byung Woo Jhun, Se Jin Kim, Kang Kim, Ji Eun Lee Tags: Original Article Source Type: research

The effect of vitamin D on airway reactivity and inflammation in asthmatic children: A double‐blind placebo‐controlled trial
ConclusionsIn our small group of children with mild asthma, no difference could be demonstrated between the effect of vitamin D and placebo, despite significant increases in vitamin D blood levels. Larger interventional studies are needed to fully explore the possible effect of vitamin D in asthma. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 1, 2014 Category: Respiratory Medicine Authors: Ronen Bar Yoseph, Galit Livnat, Zeev Schnapp, Fahed Hakim, Husein Dabbah, Aviv Goldbart, Lea Bentur Tags: Original Article: Asthma Source Type: research

Red cell distribution width is increased in chronic thromboembolic pulmonary hypertension
ConclusionIncreased RDW level may be an acceptable diagnostic parameter for CTEPH. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 1, 2014 Category: Respiratory Medicine Authors: Wang Wang, Jie Liu, Yuan‐hua Yang, Zhen‐guo Zhai, Chen Wang, Jun Wang Tags: Original Article Source Type: research

Pulmonary function impairment in patients with chronic heart failure: Lower limit of normal versus conventional cutoff values
Conclusion: Pulmonary function abnormalities, especially diffusion impairment and airway obstruction, were highly prevalent in patients with chronic HF. Conventional cutoff values classified more patients with diffusion impairment, airway obstruction, or a mixed category compared to the LLN. (Source: Heart and Lung)
Source: Heart and Lung - July 1, 2014 Category: Intensive Care Authors: Armine G. Minasian, Frank J.J. van den Elshout, P.N. Richard Dekhuijzen, Petra J.E. Vos, Frank F. Willems, Paul J.P.C. van den Bergh, Yvonne F. Heijdra Tags: Care of Patients with Heart Failure or Pulmonary Hypertension Source Type: research

Variation in daily median respiratory rate identifies patients at higher risk of worsening HF in 30 days
This study evaluated the ability of variation in RR to predict HF events in ambulatory HF patients. (Source: Heart and Lung)
Source: Heart and Lung - July 1, 2014 Category: Intensive Care Authors: John Boehmer, Qi An, Yi Zhang Tags: 2014 AAHFN 10th Annual Conference Source Type: research

Comparison of intranasal and intramuscular ketamine‐midazolam combination in cats
ConclusionsThe results substantiated that INS ketamine‐midazolam can produce effective sedation in cats. Clinical relevanceIntranasal (INS) administration of ketamine‐midazolam is atraumatic, and its use may avoid the pain of injection of ketamine combinations when this drug is used to induce sedation in cats. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 1, 2014 Category: Veterinary Research Authors: Mehdi Marjani, Vahid Akbarinejad, Mohsen Bagheri Tags: Short Communication Source Type: research

A comparison of low dose tiletamine‐zolazepam or acepromazine combined with methadone for pre‐anaesthetic medication in cats
Conclusion and clinical relevanceLow dose tiletamine‐zolazepam combined with methadone provided superior sedation to ACE. Recovery quality was similar, although time to standing was longer. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 1, 2014 Category: Veterinary Research Authors: Alastair Mair, Heide Kloeppel, Kim Ticehurst Tags: Short Communication Source Type: research

Comparison of respiratory function during TIVA and isoflurane anaesthesia in ponies Part II: breathing patterns and transdiaphragmatic pressure
Conclusion and clinical relevanceMarked differences in breathing pattern and transdiaphragmatic pressure exist during inhalation‐ and TIVA and these should be taken into account for clinical estimation of anaesthetic depth. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 1, 2014 Category: Veterinary Research Authors: Lidia Kowalczyk, Barbara Steblaj, Stijn Schauvliege, Johannes Peter Schramel, Kiriaki Pavlidou, Ioannis Savvas, Luc Duchateau, Frank Gasthuys, Yves Moens Tags: Research Paper Source Type: research

Greater fear reactivity and psychophysiological hyperactivity among infants with later conduct problems and callous‐unemotional traits
ConclusionsThe discrepancy between the biobehavioral correlates of conduct problems with callous‐unemotional traits in infancy and those reported from studies of older children and adults suggests that the etiology of this behavioral phenotype may be more complex than a simple genetic maturation model. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - July 1, 2014 Category: Psychiatry Authors: William R. Mills‐Koonce, Nicholas J. Wagner, Michael T. Willoughby, Cynthia Stifter, Clancy Blair, Douglas A. Granger, Tags: Original Article Source Type: research

Genetic diversity and molecular epidemiology of human rhinoviruses in South Africa
ConclusionAll three type of RV were identified in South Africa, although RV‐A and RV‐C were more common than RV‐B. RV was associated with symptomatic respiratory illness; however, there was no association between RV type and disease severity. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 1, 2014 Category: Infectious Diseases Authors: Marthi A. Pretorius, Stefano Tempia, Florette K. Treurnicht, Sibongile Walaza, Adam L. Cohen, Jocelyn Moyes, Orienka Hellferscee, Ebrahim Variava, Halima Dawood, Meera Chhagan, Sumayya Haffjee, Shabir A. Madhi, Cheryl Cohen, Marietjie Venter Tags: Original Article Source Type: research

A 9-month-old boy with respiratory distress and a unilateral dysplastic kidney.
PMID: 24977671 [PubMed - in process] (Source: Pediatric Annals)
Source: Pediatric Annals - July 1, 2014 Category: Pediatrics Authors: Listernick R Tags: Pediatr Ann Source Type: research

Trends in wheeze in Dutch school children and the role of medication use
ConclusionAn increasing trend of Dutch school children with “no wheeze,” and decreasing trends of children with “discontinued” and “continued” wheeze between 1989 and 2005 could not be explained by (increased) medication use. This suggests that wheeze prevalence is not masked by medication use, but is truly declining. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 1, 2014 Category: Respiratory Medicine Authors: Dianne de Korte‐de Boer, Monique Mommers, Cindy M.L. Gielkens‐Sijstermans, Huub M.H. Creemers, Frans J.M. Feron, Onno C.P. van Schayck Tags: Original Article: Epidemiology Source Type: research

Using a mobile health application to support self-management in COPD: a qualitative study.
CONCLUSION: Patients were able to use the mHealth application, interpret clinical data, and use these within their self-management approach regardless of previous knowledge. Telehealth interventions can complement current clinical care pathways to support self-management behaviour. PMID: 24982491 [PubMed - in process] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 1, 2014 Category: Primary Care Authors: Williams V, Price J, Hardinge M, Tarassenko L, Farmer A Tags: Br J Gen Pract Source Type: research

Mounier-kuhn syndrome. Imaging and bronchoscopic findings.
PMID: 24983230 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: El-Kersh K, Yasin M, Cavallazzi R, Perez RL Tags: Am J Respir Crit Care Med Source Type: research

Placental transmogrification of the lung: a rare cause of unilateral bullous disease.
PMID: 24983229 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Mohning MP, Schwarz MI, McKinley SJ Tags: Am J Respir Crit Care Med Source Type: research

Lung Elastance and Transpulmonary Pressure May Be Determined without Using Esophageal Pressure Measurements.
PMID: 24983228 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Stenqvist O, Lundin S Tags: Am J Respir Crit Care Med Source Type: research

Reply: the beneficial effect of statins on asthma exacerbations: another point of view.
PMID: 24983227 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Tse SM, Wu AC Tags: Am J Respir Crit Care Med Source Type: research

The beneficial effect of statins on asthma exacerbations: another point of view.
PMID: 24983226 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Chang K, Shin JI Tags: Am J Respir Crit Care Med Source Type: research

Reply: Reversal of Vascular Leak with Imatinib: A Role for IL-2?
PMID: 24983225 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: van Nieuw Amerongen GP, Aman J, Vonk Noordegraaf A Tags: Am J Respir Crit Care Med Source Type: research

Reversal of Vascular Leak with Imatinib: A Role for IL-2?
PMID: 24983224 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Shin JI, Eisenhut M Tags: Am J Respir Crit Care Med Source Type: research

Reply: the largest problem with climate change policy is not a future event.
PMID: 24983223 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Rice MB, Thurston GD, Balmes JR, Pinkerton KE Tags: Am J Respir Crit Care Med Source Type: research

The largest problem with climate change policy is not a future event.
PMID: 24983222 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Smith PG Tags: Am J Respir Crit Care Med Source Type: research

Sleep-related Periodic Breathing Does Not Acclimatize to Chronic Hypobaric Hypoxia: A 1-Year Study at High Altitude in Antarctica.
PMID: 24983221 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Tellez HF, Mairesse O, Macdonald-Nethercott E, Neyt X, Meeusen R, Pattyn N Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary arterial mycotic pseudoaneurysms in a patient with invasive pulmonary aspergillosis. Successful occlusion by coils.
PMID: 24983220 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Didier M, Guedin P, Staub F, Catherinot E, Rivaud E, Scherrer A, Tcherakian C, Couderc LJ Tags: Am J Respir Crit Care Med Source Type: research

Update in sepsis and pulmonary infections 2013.
Abstract The Journal has been in the vanguard of publications of the respiratory microbiome, including a National Institutes of Health Workshop report, establishing the normal microbiome in patients with various risks, and in the correlation of microbiome changes with disease exacerbations and lung transplant. A new classification scheme for healthcare-associated pneumonia, risks for nosocomial Pseudomonas pneumonia, and associations between community-acquired pneumonia and risks or outcomes have been reported. The increasingly recognized role of viral respiratory tract infections was reflected in publications rega...
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Wunderink RG, Walley KR Tags: Am J Respir Crit Care Med Source Type: research

Update in lung transplantation 2013.
Abstract Research in pulmonary transplantation is actively evolving in quality and scope to meet the challenges of a growing population of lung allograft recipients. In 2013, research groups leveraged large publicly available datasets in addition to multicenter research networks and single-center studies to make significant contributions to our knowledge and clinical care in the areas of donor use, clinical transplant outcomes, mechanisms of rejection, infectious complications, and chronic allograft dysfunction. PMID: 24983218 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 1, 2014 Category: Respiratory Medicine Authors: Todd JL, Christie JD, Palmer SM Tags: Am J Respir Crit Care Med Source Type: research