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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Exposure to arginine analog canavanine induces aberrant mitochondrial translation products, mitoribosome stalling, and instability of the mitochondrial proteome.
Abstract Impairment of mitochondrial protein homeostasis disrupts mitochondrial function and causes human diseases and aging, but the molecular mechanisms of protein synthesis and quality control in mammalian mitochondria are not fully understood. Here we demonstrate in human cells that misincorporation of an arginine analogue, canavanine, during mitochondrial protein synthesis, induced aberrant translation products and destabilized the mtDNA-encoded proteome, leading to loss of mitochondrial respiratory chain complexes. Furthermore, in the presence of a high concentration of canavanine, mitoribosome stalling could...
Source: The International Journal of Biochemistry and Cell Biology - June 24, 2015 Category: Biochemistry Authors: Konovalova S, Hilander T, Loayza-Puch F, Rooijers K, Agami R, Tyynismaa H Tags: Int J Biochem Cell Biol Source Type: research

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine.
The objective of this study was to determine the impact of DON naturally contaminated feed on the immune response generated following vaccination with PRRSV live attenuated vaccine. Eighteen pigs were randomly divided into three experimental groups of 6 animals based on DON content of the diets (0, 2.5 and 3.5mg DON/kg). They were fed these rations one week prior to the vaccination and for all the duration of the immune response evaluation. All pigs were vaccinated intra-muscularly with one dose of Ingelvac(®) PRRSV modified live vaccine (MLV). Blood samples were collected at day -1, 6, 13, 20, 27 and 35 post vaccination ...
Source: Vaccine - June 24, 2015 Category: Allergy & Immunology Authors: Savard C, Gagnon CA, Chorfi Y Tags: Vaccine Source Type: research

Acute Respiratory Distress Syndrome With and Without Extracorporeal Membrane Oxygenation: A Score Matched Study.
CONCLUSIONS: Patients with ARDS who received ECMO treatment had higher inhospital survival rates than did those with a similar disease severity and at a similar age who did not receive ECMO. PMID: 26116481 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 24, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tsai HC, Chang CH, Tsai FC, Fan PC, Juan KC, Lin CY, Yang HY, Kao KC, Fang JT, Yang CW, Chang SW, Chen YC Tags: Ann Thorac Surg Source Type: research

Is surgical plication necessary in diaphragm eventration?
CONCLUSION: Researchers of this study believe that more distinctive decisions need to be taken while identifying patients for surgery in unilateral diaphragm eventrations, especially in the adult patient group; surgical option should be used for cases in which the eventrated diaphragm results in mediastinal shift and respiratory failure. PMID: 26117205 [PubMed - as supplied by publisher] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 24, 2015 Category: Surgery Authors: Özkan S, Yazici Ü, Aydin E, Karaoğlanoğlu N Tags: Asian J Surg Source Type: research

Tuberous Sclerosis Complex: State-of-the-Art Review with a Focus on Pulmonary Involvement
Abstract Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disease with high phenotypic variability. The incidence is approximately one in 5000–10,000 births. TSC is characterized by widespread hamartomas and benign or rarely malignant neoplasms affecting various organs, most commonly the brain, skin, retinas, kidneys, heart, and lungs. The wide range of organs affected reflects the roles of TSC1 and TSC2 genes in the regulation of cell proliferation and differentiation. Clinical diagnostic criteria are important because genetic testing does not identify the mutation in up to 25 % of pati...
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence
Abstract Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised su...
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

A Giant Cell Tumor Arising from the Anterior Costal Arc in a Young Man
(Source: Lung)
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

Levodropropizine for treating cough in adult and children: a meta-analysis of published studies.
CONCLUSIONS: This analysis indicates that levodropropizine is an effective antitussive drug in children and adults, with statistically significant better overall efficacy outcomes vs. central antitussive drugs (codeine, cloperastine, dextromethorphan) in terms of reducing cough intensity and frequency, and nocturnal awakenings. This result further reinforces the favorable benefit/risk profile of levodropropizine in the management of cough. The efficacy of levodropropizine in the treatment of cough in children and adults is higher than that of the common centrally-acting anti-tussive. PMID: 26097707 [PubMed - as supplie...
Source: Respiratory Care - June 23, 2015 Category: Respiratory Medicine Authors: Zanasi A, Lanata L, Fontana G, Saibene F, Dicpinigaitis P, De Blasio F Tags: Multidiscip Respir Med Source Type: research

The Case Files: Solid Organ Injury and Hemorrhagic Shock after a Fall
By Charles Burtis, MD; Ann Haynes, MD & Andrew King, MD  A 59-year-old woman presented to the emergency department complaining of worsening abdominal pain and distension as well as four episodes of syncope and lightheadedness. The patient reported a past medical history of hypertension and hypothyroidism, but denied other comorbidities. The patient reported that she was walking her dog the previous night when the dog bolted forward, causing her to lose her balance and fall forward. The patient reported that she was able to tuck into a ball and roll, sustaining minor trauma only to her right side. She denied any hea...
Source: The Case Files - June 23, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids. Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumulation type II and Karak syndrome. More recently, PLA2G6 was identified as the causative gene in a subgroup of patients with autosomal recessive early-onset dystonia-parkinsonism. Neuropathological examination revealed widespread Lewy body pathology and the accumulation of hyperphosphorylated tau, supporting a link between PLA2G...
Source: Brain - June 23, 2015 Category: Neurology Authors: Kinghorn, K. J., Castillo-Quan, J. I., Bartolome, F., Angelova, P. R., Li, L., Pope, S., Cocheme, H. M., Khan, S., Asghari, S., Bhatia, K. P., Hardy, J., Abramov, A. Y., Partridge, L. Tags: Original Articles Source Type: research

When to Suspect Sleep Apnea and What to Do About It
The objectives of treatment are to improve symptoms, quality of life, and cardiovascular outcomes. The mainstay of treatment for moderate-to-severe OSA is positive airway pressure (PAP). Automated PAP devices may be used in uncomplicated OSA, whereas continuous fixed PAP is the treatment of choice for other patients with OSA, and may also treat a proportion of patients with CSA-CSR. A form of bi-level PAP known as adaptive servoventilation is effective in treating a majority of patients with CSA-CSR. (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - June 23, 2015 Category: Cardiology Source Type: research

Characterization of exercise limitations by evaluating individual cardiac output patterns: a prospective cohort study in patients with chronic heart failure
Conclusions: The study revealed considerable heterogeneity in the nature of exercise limitations between moderately impaired CHF patients. In one third of the study population a plateau or decrease in Q towards peak exercise was demonstrated, which is indicative of a central hemodynamic exercise limitation. A central hemodynamic exercise limitation was associated with an impairment to augment stroke volume and heart rate. (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - June 23, 2015 Category: Cardiology Authors: Ruud SpeeVictor NiemeijerBart WesselsJasper JansenPieter WijnPieter DoevendansHareld Kemps Source Type: research

Focal liver lesions detection: comparison of respiratory-triggering, triggering and tracking navigator and tracking-only navigator in diffusion-weighted imaging
Conclusion Image quality was better for RT and TT compared to TRON. Overall sensitivities for FLL detection were comparable between techniques and readers. (Source: European Journal of Radiology)
Source: European Journal of Radiology - June 23, 2015 Category: Radiology Source Type: research

Prognostic value of the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification in stage IB Lung adenocarcinoma
Conclusion Our study revealed that the new IASLC/ATS/ERS classification was an independent prognostic factor of pathological stage IB adenocarcinoma. This new classification is valuable of screening out high risk patients to receive postoperative adjuvant therapy. (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - June 23, 2015 Category: Surgery Source Type: research

Whole-exome sequencing identifies novel ECHS1 mutations in Leigh syndrome
Abstract Leigh syndrome (LS) is a rare heterogeneous progressive neurodegenerative disorder usually presenting in infancy or early childhood. Clinical presentation is variable and includes psychomotor delay or regression, acute neurological or acidotic episodes, hypotonia, ataxia, spasticity, movement disorders, and corresponding anomalies of the basal ganglia and brain stem on magnetic resonance imaging. To date, 35 genes have been associated with LS, mostly involved in mitochondrial respiratory chain function and encoded in either nuclear or mitochondrial DNA. We used whole-exome sequencing to identify disease-c...
Source: Human Genetics - June 23, 2015 Category: Genetics & Stem Cells Source Type: research

Plasma suPAR as a prognostic biological marker for ICU mortality in ARDS patients
Conclusion As a single biological marker, the prognostic value for death of plasma suPAR in ARDS patients is low. Plasma suPAR, however, improves the net reclassification, suggesting a potential role for suPAR in ICU mortality prediction models. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 23, 2015 Category: Intensive Care Source Type: research

Na+-motive cytochrome c oxidase [Biochemistry]
Cytochrome c oxidases (Coxs) are the basic energy transducers in the respiratory chain of the majority of aerobic organisms. Coxs studied to date are redox-driven proton-pumping enzymes belonging to one of three subfamilies: A-, B-, and C-type oxidases. The C-type oxidases (cbb3 cytochromes), which are widespread among pathogenic bacteria, are... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - June 23, 2015 Category: Science Authors: Muntyan, M. S., Cherepanov, D. A., Malinen, A. M., Bloch, D. A., Sorokin, D. Y., Severina, I. I., Ivashina, T. V., Lahti, R., Muyzer, G., Skulachev, V. P. Tags: Biological Sciences Source Type: research

Oral zinc and common childhood infections—An update
Publication date: July 2015 Source:Journal of Trace Elements in Medicine and Biology, Volume 31 Author(s): Sudha Basnet , Maria Mathisen , Tor A. Strand Zinc is an essential micronutrient important for growth and for normal function of the immune system. Many children in developing countries have inadequate zinc nutrition. Routine zinc supplementation reduces the risk of respiratory infections and diarrhea, the two leading causes of morbidity and mortality in young children worldwide. In childhood diarrhea oral zinc also reduces illness duration and risk of persistent episodes. Oral zinc is therefore recommended for the ...
Source: Journal of Trace Elements in Medicine and Biology - June 23, 2015 Category: Biochemistry Source Type: research

Two-level coarse-to-fine classification algorithm for asthma wheezing recognition in children's respiratory sounds
Publication date: August 2015 Source:Biomedical Signal Processing and Control, Volume 21 Author(s): Igor Mazić , Mirjana Bonković , Barbara Džaja The paper proposes a two-layer pattern recognition system architecture for asthma wheezing detection in recorded children's respiratory sounds. The first layer consists of two SVM classifiers specifically designed as a cascade stacked in parallel to emphasize the differences among signals with similar acoustic properties, such as wheezes and inspiratory stridors. The second layer is realized using a digital detection threshold, which further upgrades the proposed structure w...
Source: Biomedical Signal Processing and Control - June 23, 2015 Category: Biomedical Science Source Type: research

Impact of particulate matter and ammonia on average daily weight gain, mortality and lung lesions in pigs
Publication date: Available online 18 June 2015 Source:Preventive Veterinary Medicine Author(s): A. Michiels , S. Piepers , T. Ulens , N. Van Ransbeeck , R. Del Pozo Sacristán , A. Sierens , F. Haesebrouck , P. Demeyer , D. Maes The present study investigated the simultaneous influence of particulate matter (PM10) and ammonia (NH3) on performance, lung lesions and the presence of Mycoplasma hyopneumoniae (M. hyopneumoniae) in finishing pigs. A pig herd experiencing clinical problems of M. hyopneumoniae infections was selected. In total, 1095 finishing pigs of two replicates in eight compartments each were investigated d...
Source: Preventive Veterinary Medicine - June 23, 2015 Category: Veterinary Research Source Type: research

Limited Efficacy of Antimicrobial Metaphylaxis in Finishing Pigs: A randomized clinical trial
In this study we examined the value of using AM in commercially reared, late finishing pigs, from farms with endemic PRDC. A total of 732 pigs from four AIAO wean to market sources, were blocked into 2 matching cohorts, based on enrollment body weight, sex, and rectal temperature. The cohorts received either control (C) or AM (Tulathromycin 2.5mg/kg IM, Zoetis, Florham Park, NJ, USA). Post treatment weight gain over the 21 day period was used as a measure of health and productivity. The AM treated pigs in the lowest weight quartile at enrollment, showed a significantly improved weight gain over controls (18.5kg vs. 16.4kg,...
Source: Preventive Veterinary Medicine - June 23, 2015 Category: Veterinary Research Source Type: research

Working memory impairment and its associated sleep-related respiratory parameters in children with obstructive sleep apnea
• OSA children had poorer verbal working memory (WM), compared to controls.• No significant group differences were found in the visuo-spatial domain.• OSA impacted verbal working memory above and beyond basic attentional impairment.• Obstructive apnoea hypopnea index predicted basic storage deficits in verbal WM.• Oxygen saturation nadir predicted executive deficits of verbal WM. (Source: Sleep Medicine)
Source: Sleep Medicine - June 23, 2015 Category: Sleep Medicine Authors: Esther Yuet Ying Lau, Elizabeth W.M. Choi, Esther S.K. Lai, Kristy N.T. Lau, C.T. Au, W.H. Yung, Albert M. Li Tags: Original Article Source Type: research

Pulmonary Resection for Lung Cancer in Patients With Idiopathic Interstitial Pneumonia
Conclusions Idiopathic pulmonary fibrosis is independently associated with poorer overall survival in patients with lung cancer who undergo pulmonary resection. The decision whether to perform surgery in patients who have lung cancer with IIP should therefore take into account the subtype of IIP and the poorer outcomes associated with IPF. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Lung allocation score and health-related quality of life in Japanese candidates for lung transplantation
CONCLUSIONS The LAS was significantly related to mortality in lung transplant candidates in Japan, while, despite its multidimensional scoring, its relationship with health-related quality of life was only weak. Their severity assessment system may be more focused on patients' health and symptoms. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Chen, F., Oga, T., Yamada, T., Sato, M., Aoyama, A., Chin, K., Date, H. Tags: Trachea and bronchi Thoracic Source Type: research

Percutaneous dilatational tracheostomy following total artificial heart implantation
In conclusion, percutaneous dilatational tracheostomy in total artificial heart patients is safe. Considering the well-known benefits of early tracheotomy over prolonged translaryngeal intubation, we advocate early timing of therapy in cases of prolonged mechanical ventilation. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Spiliopoulos, S., Dimitriou, A. M., Serrano, M. R., Guersoy, D., Autschbach, R., Goetzenich, A., Koerfer, R., Tenderich, G. Tags: Peripheral vascular Adult Cardiac Source Type: research

Implantation of a total abdominal mesh plastic ending up in multiple, lethal right heart injuries
We present the case of a 62-year old patient who had an elective surgery to implant a total abdominal plastic mesh due to massive herniation after prior lower body gun shots and deep wound infections. Twenty-four hours after the operation, the patient's condition deteriorated, ST-deviation occurred and the Troponin I test was positive. On admission, the patient needed moderate catecholamine therapy and echocardiography showed a pericardial effusion (>3 cm). Puncture of the effusion was impossible due to the plastic mesh and the patient was transferred to the operating room. A subxiphoidal pericardial incision was perfor...
Source: Interactive CardioVascular and Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Endlich, M., Schiller, W., Mellert, F., Probst, C. Tags: Electrophysiology - arrhythmias, Chest wall Adult Cardiac Source Type: research

Patent foramen ovale closure following cryptogenic stroke or transient ischaemic attack: Long‐term follow‐up of 301 cases
Patent foramen ovale has been identified as a conduit for paradoxical embolism resulting in cryptogenic stroke or transient ischemic attack (TIA). We aimed to establish rates of death, recurrent stroke or TIA among patients undergoing PFO closure for stroke or TIA at our unit. A retrospective analysis of all PFO closure patients was performed between May 2004 and January 2013. Follow up was performed by mortality tracing using the Medical Research Information Service of the Office of National Statistics. With regard to stroke or TIA recurrence, written consent forms and questionnaires were mailed with follow up telephone c...
Source: Catheterization and Cardiovascular Interventions - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Mikaeil Mirzaali, Maureen Dooley, Dylan Wynne, Nina Cooter, Lorraine Lee, Peter Haworth, Romi Saha, Nicola Gainsborough, David Hildick‐Smith Tags: Valvular and Structural Heart Diseases Source Type: research

The extraction of the new components from electrogastrogram (EGG), using both adaptive filtering and electrocardiographic (ECG) derived respiration signal
Electrogastrographic examination (EGG) is a noninvasive method for an investigation of a stomach slow wave propagation. The typical range of frequency for EGG signal is from 0.015 to 0.15 Hz or (0.015–0.3 Hz) and the signal usually is captured with sampling frequency not exceeding 4 Hz. In this paper a new approach of method for recording the EGG signals with high sampling frequency (200 Hz) is proposed. High sampling frequency allows collection of signal, which includes not only EGG component but also signal from other organs of the digestive system such as the duodenum, colon as well as signal connected with resp...
Source: BioMedical Engineering OnLine - June 23, 2015 Category: Biomedical Engineering Authors: Dariusz KomorowskiStanislaw PietraszekEwaryst TkaczIvo Provaznik Source Type: research

Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance
Adenylyl cyclase type 5 knockout (AC5KO) mice have increased longevity and share a similar phenotype with calorie-restricted wild-type (WT) mice. To determine the in vivo metabolic properties of AC5 deficiency, we compared the effects of standard diet (SD) and high-fat diet (HFD) on obesity, energy balance, glucose regulation, and insulin sensitivity. AC5KO mice on SD had reduced body weight and adiposity compared with WT mice. Blood cholesterol and triglyceride levels were also significantly reduced in AC5KO mice. Indirect calorimetry demonstrated increased oxygen consumption, respiratory exchange ratio, and energy expend...
Source: Diabetes - June 23, 2015 Category: Endocrinology Authors: Ho, D.; Zhao, X.; Yan, L.; Yuan, C.; Zong, H.; Vatner, D. E.; Pessin, J. E.; Vatner, S. F. Tags: Pharmacology and Therapeutics Source Type: research

Design and analysis of a pharmacist-enhanced antimicrobial stewardship program in Thailand
Conclusion Our study suggests measurable treatment benefits associated with international IDCP training and the integration of adjunct IDCP services into hospital-based ASPs. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - June 23, 2015 Category: Infectious Diseases Source Type: research

Airway Epithelial Expression Quantitative Trait Loci Reveal Genes Underlying Asthma and Other Airway Diseases.
CONCLUSION: The airway epithelial eQTLs described in this study are complementary to previously reported lung eQTLs and represent a powerful resource to link GWAS associated variants to their regulatory function and thus elucidate the molecular mechanisms underlying asthma and airway related conditions. PMID: 26102239 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - June 23, 2015 Category: Molecular Biology Authors: Luo W, Obeidat M, Di Narzo AF, Chen R, Sin DD, Paré PD, Hao K Tags: Am J Respir Cell Mol Biol Source Type: research

The lung communication network.
Abstract The different types of cells in the lung, from the conducting airway epithelium to the alveolar epithelium and the pulmonary vasculature, are interconnected by gap junctions. The specific profile of gap junction proteins, the connexins, expressed in these different cell types forms compartments of intercellular communication that can be further shaped by the release of extracellular nucleotides via pannexin1 channels. In this review, we focus on the physiology of connexins and pannexins and describe how this lung communication network modulates lung function and host defenses in conductive and respiratory ...
Source: Cellular and Molecular Life Sciences : CMLS - June 23, 2015 Category: Cytology Authors: Losa D, Chanson M Tags: Cell Mol Life Sci Source Type: research

Lung ultrasound in the diagnosis and monitoring of community acquired pneumonia in children
Lung ultrasound (LUS) is as an easily accessible, radiation-free imaging technique that might be used as a diagnostic tool in community-acquired pneumonia (CAP).The aim of the study was to evaluate the usefulness and accuracy of LUS in the diagnosis and monitoring of childhood CAP.One hundred six consecutive children aged between 1 and 213 (median 52.5) months referred to the hospital with suspicion of CAP were enrolled. All patients underwent LUS on the day of admission, followed by chest radiograph (CXR). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 23, 2015 Category: Respiratory Medicine Authors: Emilia Urbankowska, Katarzyna Krenke, Łukasz Drobczyński, Piotr Korczyński, Tomasz Urbankowski, Marta Krawiec, Grażyna Kraj, Michał Brzewski, Marek Kulus Source Type: research

Targeting ion channels in cystic fibrosis
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause a characteristic defect in epithelial ion transport that plays a central role in the pathogenesis of cystic fibrosis (CF). Hence, pharmacological correction of this ion transport defect by targeting of mutant CFTR, or alternative ion channels that may compensate for CFTR dysfunction, has long been considered as an attractive approach to a causal therapy of this life-limiting disease. The recent introduction of the CFTR potentiator ivacaftor into the therapy of a subgroup of patients with specific CFTR mutations was a major milestone and ...
Source: Journal of Cystic Fibrosis - June 23, 2015 Category: Respiratory Medicine Authors: Marcus A. Mall, Luis J.V. Galietta Tags: Review Source Type: research

Misconceptions in the assessment of cough peak flow measurements for extubation or decanulation protocols
Publication date: Available online 22 June 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): M. Chiou , J.R. Bach , M.R. Gonçalves , L. Vudayagiri (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - June 23, 2015 Category: Respiratory Medicine Source Type: research

Pteropine Orthoreovirus infection among out‐patients with acute upper respiratory tract infection in Malaysia
This study aims to assess the incidence rate of Pteropine orthreovirus (PRV) infection in patients with acute upper respiratory tract infection (URTI) in a suburban setting in Malaysia, where bats are known to be present in the neighborhood. Using molecular detection of PRVs directly from oropharyngeal swabs, our study demonstrates PRV is among one of the common causative agents of acute URTI with cough and sore‐throat as the commonest presenting clinical features. Phylogenetic analysis on partial major outer and inner capsid proteins shows that these PRV strains are closely related to Melaka and Kampar viruses previousl...
Source: Journal of Medical Virology - June 23, 2015 Category: Virology Authors: Kenny Voon, Yeh Fong Tan, Pooi Pooi Leong, Cheong Lieng Teng, Rajasekaran Gunnasekaran, Kamsiah Ujang, Kaw Bing Chua, Lin‐Fa Wang Tags: Short Communication Source Type: research

Erectile Dysfunction is Associated with Subsequent Cardiovascular and Respiratory Mortality in Cohort of 1,436 Chinese Elderly Men
ConclusionED is significantly associated with subsequent all‐cause mortality, possibly via its association with cardiovascular and respiratory mortality. Primary care practitioners should pay attention to ED patients' cardiovascular and respiratory risk profiles, which may benefit their prognosis. Chung RY, Chan D, Woo J, Kwok T, Leung JCS, Lai JTT, and Wong SYS. Erectile dysfunction is associated with subsequent cardiovascular and respiratory mortality in cohort of 1,436 Chinese elderly men. J Sex Med **;**:**–**. (Source: The Journal of Sexual Medicine)
Source: The Journal of Sexual Medicine - June 23, 2015 Category: Sexual Medicine Authors: Roger Y. Chung, Dicken Chan, Jean Woo, Timothy Kwok, Jason C.S. Leung, Francisco T.T. Lai, Samuel Y.S. Wong Tags: Original Research Source Type: research

Respiratory Distress Following Cleft Palate Repair in Children With Robin Sequence.
CONCLUSION:   Despite delayed closure compared with children without Robin sequence, 30% of the children with Robin sequence developed respiratory distress following palatoplasty, which resolved within a few days. This study emphasizes the need for close perioperative monitoring of patients with Robin sequence who undergo palatoplasty. PMID: 26101809 [PubMed - as supplied by publisher] (Source: The Cleft Palate-Craniofacial Journal)
Source: The Cleft Palate-Craniofacial Journal - June 23, 2015 Category: ENT & OMF Authors: van Lieshout MJ, Voshol IE, Joosten KF, van der Schroeff MP, Mathijssen IM, Koudstaal MJ, Wolvius EB Tags: Cleft Palate Craniofac J Source Type: research

Nocturnal Hypoxemia Severity Determines Renin-Angiotensin System Activity in Obstructive Sleep Apnea.
CONCLUSION: The severity of nocturnal hypoxemia influences the magnitude of renal, but not the systemic, RAS activation independently of obesity in patients with OSA. PMID: 26102156 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 23, 2015 Category: Respiratory Medicine Authors: Zalucky AA, Nicholl DD, Hanly PJ, Poulin MJ, Turin TC, Walji S, Handley GB, Raneri JK, Sola DY, Ahmed SB Tags: Am J Respir Crit Care Med Source Type: research

Ultrasound signs of pulmonary fibrosis in systemic sclerosis as timely indicators for chest computed tomography.
CONCLUSIONS: TUS imaging of pleural/subpleural structures can detect ultrasonographic signs of initial PF prior to the onset of respiratory symptoms and function test abnormalities and, together with current criteria, could thereby enable exclusion of PF in SSc patients. Indicating some patients for selective referral to HRCT can thereby delay unwarranted procedures, provided that pulmonary function and TUS images are stable. PMID: 26099251 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - June 23, 2015 Category: Rheumatology Authors: Sperandeo M, Cata A, Molinaro F, Trovato FM, Catalano D, Simeone A, Varriale A, Martines GF, Trovato G Tags: Scand J Rheumatol Source Type: research

Transcriptional remodeling in response to transfer upon carbon-limited or metformin-supplemented media in S. cerevisiae and its effect on chronological life span.
In this study, the effects of caloric restriction and metformin, a dietary mimetic pharmaceutical, on yeast CLS are compared. Saccharomyces cerevisiae cells grown in synthetic dextrose complete (SDC) up to mid-exponential phase were either treated with metformin or were subjected to glucose limitation. The impacts of these perturbations were analyzed via transcriptomics, and the common (stimulation of glucose uptake, induction of mitochondrial maintenance, and reduction of protein translation) and divergent (stimulation of aerobic respiration and reprogramming of respiratory electron transport chain (ETC)) cellular respons...
Source: Applied Microbiology and Biotechnology - June 23, 2015 Category: Microbiology Authors: Borklu-Yucel E, Eraslan S, Ulgen KO Tags: Appl Microbiol Biotechnol Source Type: research

Impact of 4D-(18)FDG-PET/CT imaging on target volume delineation in SBRT patients with central versus peripheral lung tumors. Multi-reader comparative study.
CONCLUSION: The addition of co-registered 4DPET data to 4DCT based target volume delineation for SBRT of centrally located lung tumors increases the inter-observer agreement and may help to avoid geographic misses. PMID: 26116339 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - June 23, 2015 Category: Radiology Authors: Chirindel A, Adebahr S, Schuster D, Schimek-Jasch T, Schanne DH, Nemer U, Mix M, Meyer P, Grosu AL, Brunner T, Nestle U Tags: Radiother Oncol Source Type: research

Lipid rafts both in cellular membrane and viral envelope are critical for PRRSV efficient infection.
In this study, we investigated the importance of cellular and viral lipid rafts in PRRSV infection. First, we demonstrated that PRRSV glycoproteins, Gp3 and Gp4, were associated with lipid rafts during viral entry, and disruption of cellular lipid rafts inhibited PRRSV entry. We also showed the raft-location of CD163, which might contribute to the glycoproteins-raft association. Subsequently, raft disruption caused a significant reduction of viral RNA production. Moreover, Nsp9 was shown to be distributed in rafts, suggesting that rafts probably serve as a platform for PRRSV replication. Finally, we confirmed that disassem...
Source: Virology - June 23, 2015 Category: Virology Authors: Yang Q, Zhang Q, Tang J, Feng WH Tags: Virology Source Type: research

Influenza vaccine: Delayed vaccination schedules and missed opportunities in children under 2 years old.
CONCLUSIONS: High frequency of delayed vaccination schedules and missed opportunities were detected. Parents had little concern about the safety of influenza vaccine. PMID: 26116256 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - June 23, 2015 Category: Allergy & Immunology Authors: Gentile A, Juárez M, Hernandez S, Moya A, Bakir J, Lucion M Tags: Vaccine Source Type: research

A recombinant varicella vaccine harboring a respiratory syncytial virus gene induces humoral immunity.
Abstract The varicella-zoster virus (VZV) Oka vaccine strain (vOka) is highly efficient and causes few adverse events; therefore, it is used worldwide. We previously constructed recombinant vOka (rvOka) harboring the mumps virus gene. Immunizing guinea pigs with rvOka induced the production of neutralizing antibodies against the mumps virus and VZV. Here, we constructed recombinant vOka viruses containing either the respiratory syncytial virus (RSV) subgroup A fusion glycoprotein (RSV A-F) gene or RSV subgroup B fusion glycoprotein (RSV B-F) gene (rvOka-RSV A-F or rvOka-RSV B-F). Indirect immunofluorescence and Wes...
Source: Vaccine - June 23, 2015 Category: Allergy & Immunology Authors: Murakami K, Matsuura M, Ota M, Gomi Y, Yamanishi K, Mori Y Tags: Vaccine Source Type: research

Pulmonary Resection for Lung Cancer in Patients With Idiopathic Interstitial Pneumonia.
CONCLUSIONS: Idiopathic pulmonary fibrosis is independently associated with poorer overall survival in patients with lung cancer who undergo pulmonary resection. The decision whether to perform surgery in patients who have lung cancer with IIP should therefore take into account the subtype of IIP and the poorer outcomes associated with IPF. PMID: 26116477 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Omori T, Tajiri M, Baba T, Ogura T, Iwasawa T, Okudela K, Takemura T, Oba MS, Maehara T, Nakayama H, Tsuboi M, Masuda M Tags: Ann Thorac Surg Source Type: research