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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Evaluation of pleural fluid YKL-40 as a marker of malignant pleural effusion
Conclusion The current study reports a finding of increased serum and pleural fluid YKL-40 levels in patients with malignant pleural effusions compared to non-malignant effusions. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - March 17, 2015 Category: Respiratory Medicine Source Type: research

Drug hypersensitivity causing organizing eosinophilic pneumonia in a pediatric patient
Conclusions Eosinophilic pneumonias are rare in the pediatric population. Peripheral eosinophilia is not necessary to make the diagnosis. Bronchoalveolar lavage is the diagnostic study of choice. Lung biopsies are rarely needed to make the diagnosis. The treatment of choice is steroids. If steroids fail to improve the patient's condition, consider IVIG, and cyclosporine A. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - March 17, 2015 Category: Respiratory Medicine Source Type: research

Recurrence of a mediastinal liposarcoma 20 years after surgery: A case of carbon ion radiotherapy resulting in fatal tracheoesophageal fistula
Publication date: Available online 16 March 2015 Source:Respiratory Investigation Author(s): Takahisa Kawamura , Keisuke Tomii , Yutaka Takahashi , Akihiko Okada , Yusuke Demizu , Nobukazu Fuwa , Yukihiro Imai (Source: Respiratory Investigation)
Source: Respiratory Investigation - March 17, 2015 Category: Respiratory Medicine Source Type: research

Sports injuries and illnesses in the Sochi 2014 Olympic Winter Games
Conclusions Overall, 12% of the athletes incurred at least one injury during the games, and 8% an illness, which is similar to prior Olympic Games. The incidence of injuries and illnesses varied substantially between sports. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - March 17, 2015 Category: Sports Medicine Authors: Soligard, T., Steffen, K., Palmer-Green, D., Aubry, M., Grant, M.-E., Meeuwisse, W., Mountjoy, M., Budgett, R., Engebretsen, L. Tags: Trauma, Injury Original article Source Type: research

Birth Order and Mortality: A Population-Based Cohort Study
This study uses Swedish population register data to investigate the relationship between birth order and mortality at ages 30 to 69 for Swedish cohorts born between 1938 and 1960, using a within-family comparison. The main analyses are conducted with discrete-time survival analysis using a within-family comparison, and the estimates are adjusted for age, mother’s age at the time of birth, and cohort. Focusing on sibships ranging in size from two to six, we find that mortality risk in adulthood increases with later birth order. The results show that the relative effect of birth order is greater among women than among men....
Source: Demography - March 17, 2015 Category: Global & Universal Source Type: research

A novel approach to the determination of clinical decision thresholds
We presented 200 clinicians with a series of web-based clinical vignettes, describing patients with possible influenza, acute coronary syndrome (ACS), pneumonia, deep vein thrombosis (DVT) and urinary tract infection (UTI). We randomly varied the probability of disease and asked whether the clinician wanted to rule out disease, order tests or rule in disease. By randomly varying the probability, we obtained clinical decisions across a broad range of disease probabilities that we used to create threshold curves. For influenza, the test (4.5% vs 32%, p<0.001) and treatment (55% vs 68%, p=0.11) thresholds were lower for US...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Ebell, M. H., Locatelli, I., Senn, N. Tags: General practice / family medicine, Influenza, Pneumonia (infectious disease), Urinary tract infections, Ischaemic heart disease, Venous thromboembolism, Pneumonia (respiratory medicine), Vulvovaginal disorders, Urinary tract infections Methods Source Type: research

Discontinuing inhaled steroids might not be safe in severe COPD cases
Commentary on: Magnussen H, Disse B, Rodriguez-Roisin R, et al; WISDOM Investigators. Withdrawal of inhaled glucocorticoids and exacerbations of COPD. N Engl J Med 2014;371:1285–94. Context Recommended treatment for chronic obstructive pulmonary disease (COPD) in patients with frequent exacerbations include a combination of a long-acting bronchodilator (LAB) and inhaled corticosteroids (ICS). The extra benefit on exacerbation rate of adding ICS to a dual LAB regimen has never been determined in an adequately powered trial. The authors conducted a randomised, double-blind, clinical trial to test their hypothesis that ...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Laniado-Laborin, R. Tags: Epidemiologic studies, Immunology (including allergy), Pneumonia (infectious disease), Radiology, Drugs: respiratory system, Pneumonia (respiratory medicine), Surgical diagnostic tests, Clinical diagnostic tests Therapeutics/Prevention Source Type: research

CALORIES trial offers confirmatory evidence that parenteral nutrition does not cause infectious complications in critically ill patients
Commentary on: Harvey SE, Parrott F, Harrison DA, et al.; CALORIES Trial Investigators. Trial of the route of early nutritional support in critically ill adults. N Engl J Med 2014;371:1673–84. Context Critically ill patients are hypermetabolic and have increased nutritional requirements. Major international guidelines promote early enteral nutrition (EN), however, up to 35% of all patients remain unfed 3 or more days after intensive care unit (ICU) admission.1 EN is delayed because clinicians believe it is poorly absorbed in critical illness and because they believe excess vomiting may lead to pneumonitis. Parenteral...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Doig, G. S., Simpson, F. Tags: Clinical trials (epidemiology), Epidemiologic studies, Pneumonia (infectious disease), Pneumonia (respiratory medicine) Therapeutics/Prevention Source Type: research

Bubble CPAP may be safe and efficacious for neonates in low and middle income countries, but more evidence is needed
Commentary on: Martin S, Duke T, Davis P. Efficacy and safety of bubble CPAP in neonatal care in low and middle income countries: a systematic review. Arch Dis Child Fetal Neonatal Ed 2014;99:F495–504. Context Neonatal respiratory distress associated with prematurity, surfactant deficiency, sepsis and birth asphyxia, significantly contributes to morbidity and mortality globally. In high income countries, nasal continuous positive airway pressure (CPAP) initiated in the delivery room, compared with intubation and mechanical ventilation, reduces death or bronchopulmonary dysplasia in preterm babies born <32 wee...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: McAdams, R. M. Tags: Epidemiologic studies, Injury Therapeutics/Prevention Source Type: research

Tonsillectomy or adenotonsillectomy reduces the number of sore throats in children; however, insufficient information is available on the effectiveness in adults
Commentary on: Burton MJ, Glasziou PP, Chong LY, et al. Tonsillectomy or adenotonsillectomy versus non-surgical treatment for chronic/recurrent acute tonsillitis. Cochrane Database Syst Rev 2014;11:CD001802. Context Sore throats cost the National Health Service (NHS) over £120 million per annum with approximately £60 million for general practitioner consultations and medical therapy. From 2011 to 2012, in England alone,1 secondary care costs included £10 million for bed usage by over 37 000 emergency hospital admissions and over £20 million in elective adult tonsillectomy. Upper respiratory tra...
Source: Evidence-Based Medicine - March 17, 2015 Category: Internal Medicine Authors: Haighton, C., Wilson, J. Tags: Clinical trials (epidemiology), General practice / family medicine, Ear, nose and throat/otolaryngology Therapeutics/Prevention Source Type: research

Acute rhabdomyolysis and inflammation
Abstract Rhabdomyolysis results from the rapid breakdown of skeletal muscle fibers, which leads to leakage of potentially toxic cellular content into the systemic circulation. Acquired causes by direct injury to the sarcolemma are most frequent. The inherited causes are: i) metabolic with failure of energy production, including mitochondrial fatty acid ß-oxidation defects, LPIN1 mutations, inborn errors of glycogenolysis and glycolysis, more rarely mitochondrial respiratory chain deficiency, purine defects and peroxysomal α-methyl-acyl-CoA-racemase defect (AMACR), ii) structural causes with muscle dystrophies an...
Source: Journal of Inherited Metabolic Disease - March 17, 2015 Category: Internal Medicine Source Type: research

Spectrum of combined respiratory chain defects
Abstract Inherited disorders of mitochondrial energy metabolism form a large and heterogeneous group of metabolic diseases. More than 250 gene defects have been reported to date and this number continues to grow. Mitochondrial diseases can be grouped into (1) disorders of oxidative phosphorylation (OXPHOS) subunits and their assembly factors, (2) defects of mitochondrial DNA, RNA and protein synthesis, (3) defects in the substrate-generating upstream reactions of OXPHOS, (4) defects in relevant cofactors and (5) defects in mitochondrial homeostasis. Deficiency of more than one respiratory chain enzyme is a common ...
Source: Journal of Inherited Metabolic Disease - March 17, 2015 Category: Internal Medicine Source Type: research

Variation in DNAH1 may contribute to primary ciliary dyskinesia
Conclusion: Molecular variation in DNAH1 may play a role in PCD and its potential contribution should be considered in patients where all known genes are excluded. (Source: BMC Medical Genetics)
Source: BMC Medical Genetics - March 17, 2015 Category: Genetics & Stem Cells Authors: Faiqa ImtiazRabab AllamKhushnooda RamzanMoeenaldeen Al-Sayed Source Type: research

Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta-Analysis of 18,000 Patients
Conclusions Coronary artery bypass in octogenarians can be performed safely with low early mortality. Although off-pump operations reduce the risk of early stroke, all other adverse events are comparable in on- and off-pump coronary artery bypass operations. Data regarding late mortality is at present limited; however, both on- and off-pump procedures appear to produce comparable survival. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 17, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: The Role of Abnormal Peripheral Oxygen Extraction [Original Articles]
Conclusions— In the first study to directly measure C(a-v)o2 throughout exercise in HFpEF, HFrEF, and normals, we found that peak C(a-v)o2 was a major determinant of exercise capacity in HFpEF. The important functional limitation imposed by impaired o2 extraction may reflect intrinsic abnormalities in skeletal muscle or peripheral microvascular function, and represents a potential target for therapeutic intervention. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - March 17, 2015 Category: Cardiology Authors: Dhakal, B. P., Malhotra, R., Murphy, R. M., Pappagianopoulos, P. P., Baggish, A. L., Weiner, R. B., Houstis, N. E., Eisman, A. S., Hough, S. S., Lewis, G. D. Tags: Congestive, Exercise testing Original Articles Source Type: research

Novel Microbiome-Based Therapeutics for Chronic Rhinosinusitis
Abstract The human microbiome, i.e. the collection of microbes that live on, in and interact with the human body, is extraordinarily diverse; microbiota have been detected in every tissue of the human body interrogated to date. Resident microbiota interact extensively with immune cells and epithelia at mucosal surfaces including the airways, and chronic inflammatory and allergic respiratory disorders are associated with dysbiosis of the airway microbiome. Chronic rhinosinusitis (CRS) is a heterogeneous disease with a large socioeconomic impact, and recent studies have shown that sinus inflammation is associated ...
Source: Current Allergy and Asthma Reports - March 17, 2015 Category: Allergy & Immunology Source Type: research

Laryngeal morphologic changes and epidemiology in patients with inhalation injury: A retrospective study
Inhalation injury remains a major contributor to mortality, the risk of which is comparable to infection and shock. Severe burns with large surface area are frequently combined with inhalation injury [1–3]. Inhalation injury may cause upper airway obstruction (UAO), and a combination of UAO and pulmonary interstitial edema may lead to acute respiratory distress syndrome (ARDS). UAO occurs in 20–33% of hospitalized patients with inhalation injury [4]. Because of the location and structure of the larynx in the upper airway, laryngeal injury is an important cause of UAO. (Source: Burns : Journal of the International Socie...
Source: Burns : Journal of the International Society for Burn Injuries - March 17, 2015 Category: Cosmetic Surgery Authors: Ning Fang-Gang, Chang Yang, Qiu Yu-Xuan, Rong Yan-Hua, Du Wei-Li, Wang Cheng, Wen Chun-Quan, Zhang Guo-An Source Type: research

HBV infection is associated with greater mortality in hospitalised patients compared to HCV infection or alcoholic liver disease
ConclusionsPatients hospitalised with HBV infection represent a particularly high‐risk group with poor in‐hospital outcomes and increased mortality compared to HCV infection or alcoholic liver disease. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - March 17, 2015 Category: Drugs & Pharmacology Authors: R. Rajbhandari, C. J. Danford, R. T. Chung, A. N. Ananthakrishnan Tags: Original Scientific Paper Source Type: research

Cardiac Tamponade Caused by Paradoxical Immune Reconstitution Inflammatory Syndrome
A 36-year-old woman presented with severe respiratory distress. She had a 5-year history of silent HIV-1 infection. Three months previously, she received standard antituberculous quadruple-drug formulations for treating cervical tuberculosis lymphadenitis. No major adverse events occurred. After 6 weeks, she started highly active antiretroviral therapy because of oral candidiasis, intractable diarrhea, and weight loss with increased plasma virus load to 1025,520 RNA copies/ml and a CD4 T-cell count of 40/mm3. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - March 17, 2015 Category: Emergency Medicine Authors: Yu-Tzu Tsao, Jui-Chang Chen, Wei-Chi Tsai Tags: Case report Source Type: research

Influenza virus prevalence in asymptomatic and symptomatic subjects during pandemic and postpandemic periods
Conclusions Asymptomatic household contacts of symptomatic children may play an important role in community transmission and a more proactive intervention should be considered during future pandemics. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - March 17, 2015 Category: Infectious Diseases Source Type: research

Cleaning and disinfecting environmental surfaces in health care: Toward an integrated framework for infection and occupational illness prevention
Conclusion A more integrated approach can support multidisciplinary teams with the capacity to maximize effective and safe C&amp;D in health care. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - March 17, 2015 Category: Infectious Diseases Source Type: research

MyD88-Dependent Signaling Drives Host Survival and Early Cytokine Production during Histoplasma capsulatum Infection [Host Response and Inflammation]
The ability of the innate immune system to trigger an adaptive T cell response is critical to resolution of infection with the fungal pathogen Histoplasma capsulatum. However, the signaling pathways and cell types involved in the recognition of and response to this respiratory pathogen remain poorly defined. Here, we show that MyD88, an adaptor protein vital to multiple innate immune pathways, is critically required for the host response to Histoplasma. MyD88-deficient (MyD88–/–) mice are unable to control the fungal burden and are more sensitive to Histoplasma infection than wild-type, Dectin-1–/–,...
Source: Infection and Immunity - March 17, 2015 Category: Infectious Diseases Authors: Coady, A., Sil, A. Tags: Host Response and Inflammation Source Type: research

Failure of Empirical Systemic Antifungal Therapy in Mechanically-ventilated Critically Ill Patients.
CONCLUSION: This study failed to show outcome benefits for empirical systemic antifungal therapy in the sickest critically ill non-neutropenic, non-transplanted. The post-hoc power did not allow us to conclude to an absence of treatment effect especially for specific subgroups. Studies to refine indications for empirical treatment based on surrogate markers of invasive candidiasis are warranted. PMID: 25780856 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 17, 2015 Category: Respiratory Medicine Authors: Bailly S, Bouadma L, Azoulay E, Garrouste Orgeas M, Souweine B, Schwebel C, Maubon D, Hamidfar-Roy R, Darmon M, Wolff M, Cornet M, Timsit JF Tags: Am J Respir Crit Care Med Source Type: research

Pro-resolving Action of MAG-DHA in Lung Inflammatory Models Related to Cystic Fibrosis.
CONCLUSIONS: MAG-DHA displays anti-inflammatory properties and reduces mucin overexpression in Calu-3 cells and human bronchi untreated or treated with P. aeruginosa LPS, a finding consistent with the effects of ResolvinD1, a known anti-inflammatory mediator. PMID: 25781052 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - March 17, 2015 Category: Respiratory Medicine Authors: Morin C, Cantin AM, Rousseau É, Sirois M, Sirois C, Rizcallah E, Fortin S Tags: Am J Respir Cell Mol Biol Source Type: research

TSC2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis.
Abstract Lymphangioleiomyomatosis (LAM) is a destructive lung disease of women caused by mutations in the tuberous sclerosis complex (TSC) genes. The TSC protein complex inhibits the mechanistic/mammalian Target of Rapamycin Complex 1 (mTORC1), which is a master regulator of cellular metabolism. Using mass spectrometry-based lipid profiling we analyzed LAM patient plasma and discovered elevated levels of 4 lysophosphatidylcholine (LPC) species (C16:0, C18:0, C18:1, C20:4) compared with healthy control women. To investigate whether these lipids are generated in a TSC2-dependent manner, we profiled in vitro pre-clini...
Source: Am J Respir Cell Mol... - March 17, 2015 Category: Respiratory Medicine Authors: Priolo C, Ricoult SJ, Khabibullin D, Filippakis H, Yu J, Manning BD, Clish C, Henske EP Tags: Am J Respir Cell Mol Biol Source Type: research

Potential economic impacts from improving breastfeeding rates in the UK
Conclusions The economic impact of low breastfeeding rates is substantial. Investing in services that support women who want to breast feed for longer is potentially cost saving. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - March 17, 2015 Category: Pediatrics Authors: Pokhrel, S., Quigley, M. A., Fox-Rushby, J., McCormick, F., Williams, A., Trueman, P., Dodds, R., Renfrew, M. J. Tags: Oncology, Open access, Press releases, Otitis, TB and other respiratory infections, Childhood nutrition, Reproductive medicine, Infant nutrition (including breastfeeding), Ear, nose and throat/otolaryngology Original article Source Type: research

6-MIN walk-test data in severe obstructive-sleep-apnea-hypopnea-syndrome (OSAHS) under continuous-positive-airway-pressure (CPAP) treatment
Few studies have evaluated the functional capacity of severe OSAHS. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - March 17, 2015 Category: Respiratory Medicine Authors: Helmi Ben saad, Ikram Ben hassen, Ines Ghannouchi, Imed Latiri, Sonia Rouatbi, Pierre Escourrou, Halima Ben salem, Mohamed Benzarti, Ahmed Abdelghani Source Type: research

Plain packaging and galloping consumption: respiratory disease in modern Ireland
Publication date: Available online 17 March 2015 Source:The Lancet Respiratory Medicine Author(s): Hannah Cagney (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 17, 2015 Category: Respiratory Medicine Source Type: research

Effect of “Touch Rugby” Training on the Cardiovascular Autonomic Control In Sedentary Subjects
This study aimed to explore the effects of “touch-rugby” training on the cardiovascular autonomic control in sedentary subjects. 22 adults (30–64 years old) were included in this study. Before (pre-test) and after (post-test) the period of training, cardio-respiratory recordings were achieved at rest and during a graded maximal exercise on a treadmill. The Smoothed-Pseudo-Wigner-Ville Distribution provided instantaneous time frequency components of RR intervals and systolic blood pressure variability in low- and high-frequency bands. The baroreflex sensitivity was assessed in low-frequency and high-frequency bands. B...
Source: International Journal of Sports Medicine - March 17, 2015 Category: Sports Medicine Authors: Filliau, C.Younes, M.Blanchard, A.-L.Piscione, J.Van de Louw, A.Seguret, C.Israel, J.Cottin, F. Tags: Training & Testing Source Type: research

The effect of participatory women's groups on infant feeding and child health knowledge, behaviour and outcomes in rural Bangladesh: a controlled before-and-after study
Conclusions Community mobilisation through participatory women's groups can be successfully adapted to address health knowledge and practice in relation to child's health, leading to improvements in a number of child health indicators and behaviours. (Source: Journal of Epidemiology and Community Health)
Source: Journal of Epidemiology and Community Health - March 17, 2015 Category: Epidemiology Authors: Younes, L., Houweling, T. A. J., Azad, K., Kuddus, A., Shaha, S., Haq, B., Nahar, T., Hossen, M., Beard, J., Copas, A., Prost, A., Costello, A., Fottrell, E. Tags: Epidemiologic studies, Mortality and morbidity, Open access Other topics Source Type: research

Incidence of respiratory viruses in peruvian children with acute respiratory infections
This study, conducted during the pandemic outbreak of H1N1 influenza in 2009, aims to determine the main etiological agents responsible for acute respiratory infections in children from Lima, Peru. Nasopharyngeal swabs collected from 717 children with acute respiratory infections between January 2009 and December 2010 were analyzed by multiplex RT‐PCR for 13 respiratory viruses: influenza A, B, and C virus; parainfluenza virus (PIV) 1, 2, 3, and 4; and human respiratory syncytial virus (RSV) A and B, among others. Samples were also tested with direct fluorescent‐antibodies (DFA) for six respiratory viruses. RT‐PCR an...
Source: Journal of Medical Virology - March 17, 2015 Category: Virology Authors: Juana del Valle Mendoza, Angela Cornejo‐Tapia, Pablo Weilg, Eduardo Verne, Ronald Nazario‐Fuertes, Claudia Ugarte, Luis J. del Valle, Tomás Pumarola Tags: Research Article Source Type: research

Value of a risk scoring tool to predict respiratory syncytial virus disease severity and need for hospitalization in term infants
In conclusion, the RST did not predict accurately the clinical severity of RSV bronchiolitis in term infants nor did it correlate with risk for RSV‐related hospitalization. J. Med. Virol. © 2015 Wiley Periodicals, Inc. (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - March 17, 2015 Category: Virology Authors: Rafat Mosalli, Asmaa Mostafa Abdul Moez, Mohammed Janish, Bosco Paes Tags: Research Article Source Type: research

Off-Pump Coronary Artery Bypass Reduces Early Stroke in Octogenarians: A Meta-Analysis of 18,000 Patients.
CONCLUSIONS: Coronary artery bypass in octogenarians can be performed safely with low early mortality. Although off-pump operations reduce the risk of early stroke, all other adverse events are comparable in on- and off-pump coronary artery bypass operations. Data regarding late mortality is at present limited; however, both on- and off-pump procedures appear to produce comparable survival. PMID: 25791924 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - March 17, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Altarabsheh SE, Deo SV, Rababa'h AM, Lim JY, Cho YH, Sharma V, Jung SH, Shin E, Markowitz AH, Park SJ Tags: Ann Thorac Surg Source Type: research

[How to relieve a dyspneic patient at the end of life?]
Abstract Dyspnea is a very common symptom that particularly worries the patient and his relatives. In terminally ill patients, there is no correlation between dyspnea and hypoxaemia. Although a specific cause may require an appropriate treatment, most of the time the treatment is symptomatic. This approach is based on oral or parenteral administration of opioids but with a narrower safety margin than in chronic pain patients. The use of an anxiolytic is indicated in stressful circumstances or when opioids fail. Oxygen administration should be discussed on an individual basis and not conditioned to the achievement o...
Source: Presse Medicale - March 17, 2015 Category: Journals (General) Authors: Voisin-Saltiel S Tags: Presse Med Source Type: research

Initial results of robotic esophagectomy for esophageal cancer.
CONCLUSIONS: Our results suggest that minimally invasive esophagectomy with robot-assisted thoracoscopy is safe and achieves oncological standards. PMID: 25794776 [PubMed - as supplied by publisher] (Source: Cirugia eEspanola)
Source: Cirugia eEspanola - March 17, 2015 Category: Surgery Authors: Soledad Trugeda Carrera M, José Fernández-Díaz M, Rodríguez-Sanjuán JC, Manuel-Palazuelos JC, de Diego García EM, Gómez-Fleitas M Tags: Cir Esp Source Type: research

Evaluation of endothelial biomarkers as predictors of organ failures in septic shock patients.
CONCLUSION: In septic shock patients, angiopoietine-2 is related with clinical severity during the first 24h but only endocan is able to predict the presence of respiratory failure at Day 3. PMID: 25794660 [PubMed - as supplied by publisher] (Source: Cytokine)
Source: Cytokine - March 17, 2015 Category: Molecular Biology Authors: Palud A, Parmentier-Decrucq E, Pastre J, De Freitas Caires N, Lassalle P, Mathieu D Tags: Cytokine Source Type: research

Impact of Airflow Limitation on Carotid Atherosclerosis in Coronary Artery Disease Patients
Conclusions: Ever-smokers with airflow limitation were significantly associated with severe carotid atherosclerosis among patients with coronary artery disease. These findings also provide additional insight into the correlation between airflow limitation and poor cardiovascular clinical outcomes.Respiration (Source: Respiration)
Source: Respiration - March 16, 2015 Category: Respiratory Medicine Source Type: research

Are Asthmatics Enrolled in Randomized Trials Representative of Real-Life Outpatients?
Conclusions: In a real-life setting, >40% of subjects with mild/moderate asthma are currently treated by protocols based on the results of RCTs for which they would not have been eligible. This proportion increases in elderly patients with comorbidities. These findings limit the generalizability of RCTs and advocate that complementary pragmatic studies be conducted.Respiration (Source: Respiration)
Source: Respiration - March 16, 2015 Category: Respiratory Medicine Source Type: research

Risk factors and antibiotic therapy in P. aeruginosa community‐acquired pneumonia
ConclusionsRisk factor recommended by current guidelines only detect one third of the patients admitted with CAP due to P. aeruginosa. Risk factors did not define the whole benefit observed due to empirical therapy covering P. aeruginosa. (Source: Respirology)
Source: Respirology - March 16, 2015 Category: Respiratory Medicine Authors: Oriol Sibila, Elena Laserna, Diego Jose Maselli, Juan Felipe Fernandez, Eric M. Mortensen, Antonio Anzueto, Grant Waterer, Marcos I. Restrepo Tags: Original Article Source Type: research

Sustained inflation during neonatal resuscitation
Purpose of review: Sustained inflation performed shortly after birth to help clear lung fluid and establish functional residual capacity in preterm infants is gaining popularity, but definitive evidence for its effectiveness is lacking. Although there is a sound physiologic basis for this approach, and much preclinical experimental evidence of effectiveness, the results of recent animal studies and clinical trials have been inconsistent. Recent findings: The most recent data from a multicenter randomized trial suggest a modest benefit of sustained inflation in reducing the need for mechanical ventilation in extremely-low-b...
Source: Current Opinion in Pediatrics - March 16, 2015 Category: Pediatrics Tags: NEONATOLOGY AND PERINATOLOGY: Edited by Richard A. Polin and Tara M. Randis Source Type: research

Evaluation of Paraoxonase-1 Activity in Chronic Obstructive Pulmonary Disease
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Authors’ Reply: Evaluation of Paraoxonase 1 Activity in Chronic Obstructive Pulmonary Disease
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Phrenic Nerve Conduction Abnormalities Correlate with Diaphragmatic Descent in Chronic Obstructive Pulmonary Disease
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Differences in Adherence to Common Inhaled Medications in COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Relationship between Troponin Elevation, Cardiovascular History and Adverse Events in Patients with acute exacerbation of COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Utility Scores In Patients With Oxygen-Dependent COPD: A Case-Control Study
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research