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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.
Transcriptome Profiling of the Newborn Mouse Lung Response to Acute Ozone Exposure
This study was carried out to define the effect of acute ozone exposure on the neonatal lung and to profile the transcriptome response. Newborn mice were exposed to ozone or filtered air for 3h. Total RNA was isolated from lung tissues at 6 and 24h after exposure and was subjected to microarray gene expression analysis. Compared to filtered air-exposed littermates, ozone-exposed newborn mice developed a small but significant neutrophilic airway response associated with increased CXCL1 and CXCL5 expression in the lung. Transcriptome analysis indicated that 455 genes were down-regulated and 166 genes were up-regulated by at ...
Source: Toxicological Sciences - February 20, 2014 Category: Toxicology Authors: Gabehart, K., Correll, K. A., Yang, J., Collins, M. L., Loader, J. E., Leach, S., White, C. W., Dakhama, A. Tags: Research Article Source Type: research
Maintenance of Immunological Homeostasis by Indukantha Ghritha in Patients with Recurrent Upper Respiratory Tract Infections—A Pilot Study
This study was designed to scientifically validate and evaluate the immunological response mechanisms in patients with RURI. Primarily, immunological functioning of the lymphocyte subsets, Th1 and Th2 cytokines, and immunoglobulins was evaluated before and after administration of IG in patients (n = 48) and normal subjects (n = 25) for a period of 28 days. Flow cytometry revealed a significant increase in the CD3+, CD4+ T cells and CD56+ natural killer cells with a concomitant reduction of percentage of B cells during IG treatment. Increased Th1 cytokines, IL‐2 and IFN‐γ, and decreased Th2 cytokine, IL‐4, ...
Source: Phytotherapy Research - February 20, 2014 Category: Biochemistry Authors: Rajesh Radhakrishnan, Suraj K. George, Sunil Kumar, Prabha Balaram Tags: Research Article Source Type: research
Cathepsin K overexpression modifies lung development in newborn mice
Summary Cathepsin K (CatK), contributes to the development of chronic lung disease in newborn infants, but the impact of CatK for the lungs may be multifaceted. We have previously demonstrated that low level of CatK is associated with newborn lung injury and CatK deficiency aggravates lung injury in hyperoxia‐exposed newborn mice. Thus, we hypothesized that sustained/higher expression of CatK could ameliorate hyperoxia‐induced injury and restrain the development of pulmonary fibrosis. We studied the lungs of newborn wild‐type (WT) and CatK overexpressing transgenic mice (TG) that were exposed to hyperoxia or room air...
Source: Pediatric Pulmonology - February 20, 2014 Category: Respiratory Medicine Authors: Jonni Knaapi, Riku Kiviranta, Jukka Laine, Pekka Kääpä, Heikki Lukkarinen Tags: Original Article: Neonatal Lung Disease Source Type: research
Accuracy of tidal breathing measurement of floright compared to an ultrasonic flowmeter in infants
ConclusionFloRight® accurately measures time indices and may discriminate between healthy infants and those with lung disease, but demonstrates differences in tidal volume measurements. It may be better suited to monitor breathing pattern than for TBFVL measurements. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 20, 2014 Category: Respiratory Medicine Authors: Nicole C.M. Petrus, Cindy Thamrin, Oliver Fuchs, Urs Frey Tags: Original Article: Pulmonary Physiology Source Type: research
Pseudomonas aeruginosa Type-3 secretion system dampens host defense by exploiting the NLRC4-coupled inflammasome.
Conclusion. We report a new role of the T3SS apparatus itself, independently of exotoxin translocation. Through NLRC4-inflammasome activation, the T3SS promotes IL-18 secretion, which dampens a beneficial IL-17-mediated antimicrobial host response. PMID: 24555512 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 20, 2014 Category: Respiratory Medicine Authors: Faure E, Mear JB, Faure K, Normand S, Couturier-Maillard A, Grandjean T, Balloy V, Ryffel B, Dessein R, Chignard M, Uyttenhove C, Guery B, Gosset P, Chamaillard M, Kipnis E Tags: Am J Respir Crit Care Med Source Type: research
Verrucous carcinoma of the tracheobronchial tree: an underdiagnosed entity?
Abstract To the Editor:Verrucous carcinomas, first described by Ackermann (1) in 1948, are rare, well-differentiated squamous cell carcinomas in the oropharynx (2), larynx (2-4) and oesophagus (5), and seem to be associated with Human papilloma virus (HPV) infections (6). Macroscopically, they have a warty appearance and may easily be mistaken for papillomas (4). Surprisingly, although found in the larynx, there are no descriptions of this tumour in the tracheobronchial tree.A 74-year-old male with a history of chronic obstructive pulmonary disease and former smoking was admitted for increasing shortness of breath....
Source: Respiratory Care - February 20, 2014 Category: Respiratory Medicine Authors: Steppert C, Alhanna J, Schubert J, Krugmann J, Vieth M Tags: Eur Respir J Source Type: research
Characteristics of daily arm activities in patients with COPD.
This study aimed to investigate whether and to what extent arm activities of daily living (ADL) in chronic obstructive pulmonary disease (COPD) patients differ compared to healthy controls and the extent to which they perform arm ADL at a relatively higher upper limb muscle effort.Daily arm and leg activities were assessed using accelerometers in the home environment (COPD: n = 21, healthy: n = 24; part 1). The relative efforts of the trapezius, deltoid and biceps muscles were studied using electromyography during domestic arm ADL in a laboratory setting (COPD: n = 17, healthy: n = 15; part 2).After correction for walking ...
Source: Respiratory Care - February 20, 2014 Category: Respiratory Medicine Authors: Meijer K, Annegarn J, Lima Passos V, Savelberg HH, Schols AM, Wouters EF, Spruit MA Tags: Eur Respir J Source Type: research
Wheezing phenotypes in young children: an historical cohort study.
CONCLUSIONS: The use of incidence rates contributes to the clarification of the natural history of infant wheezing. PMID: 24557527 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 20, 2014 Category: Respiratory Medicine Authors: Cano-Garcinuño A, Mora-Gandarillas I, the SLAM Study Group Tags: Prim Care Respir J Source Type: research
Chinese Waterpipe Smoking and the Risk of Chronic Obstructive Pulmonary Disease.
CONCLUSIONS: Chinese waterpipe smoking significantly increases the risk for COPD, which includes women who are exposed to the waterpipe smoke. TRIAL REGISTRY: Chinese Clinical Study.org, No: ChiCTR-CCH-12002235; URL: http://www.chictr.org/cn/ PMID: 24557573 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: She J, Yang P, Wang Y, Qin X, Fan J, Wang Y, Gao G, Luo G, Ma K, Li B, Li C, Wang X, Song Y, Bai C Tags: Chest Source Type: research
Efficacy and safety of a fixed-dose combination of indacaterol and glycopyrronium (qva149) for the treatment of copd: a systematic review.
CONCLUSIONS: Once-daily inhaled QVA149 showed superior efficacy compared with glycopyrronium, and the current standard of care tiotropium, in patients with moderate-to-severe COPD. PMID: 24556877 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Rodrigo GJ, Plaza V Tags: Chest Source Type: research
A Randomized Controlled Trial of ACE-inhibition for Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease.
CONCLUSIONS: This randomized controlled trial found that ACE-inhibition, using fosinopril for three months, did not improve quadriceps function or exercise performance in COPD patients with quadriceps weakness. (www.controlled-trials.com/ISRCTN05581879). PMID: 24556825 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Shrikrishna D, Tanner RJ, Lee JY, Natanek A, Lewis A, Murphy PB, Hart N, Moxham J, Montgomery HE, Kemp PR, Polkey MI, Hopkinson NS Tags: Chest Source Type: research
Attentional modulation of reflex cough.
CONCLUSIONS. Reflex cough can be modulated by attentional focus. Internally focused attention may be a mechanism involved in excessive (idiopathic) cough, while an external focus may be introduced as part of treatments targeting excessive cough. PMID: 24556807 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Janssens T, Silva M, Davenport PW, Van Diest I, Dupont LJ, Van den Bergh O Tags: Chest Source Type: research
Impact of Histological Subtyping on Outcome in Lobar versus Sublobar Resections for Lung Cancer: A Pilot Study.
CONCLUSIONS: Our findings corroborate the prognostic significance of the 2011 adenocarcinoma subtyping classification and additionally suggest that lobectomy does not offer an overall survival advantage over wedge/segmentectomy regardless of histologic subtype. Therefore, this finding suggests that limited resection may be appropriate for small size tumors, particularly those 2.0 cm or less with invasive histology. PMID: 24556743 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Dembitzer FR, Flores RM, Parides MK, Beasley MB Tags: Chest Source Type: research
Soluble MHC class I-related chain B molecules are increased and correlate with clinical outcomes during rhinovirus infection in healthy subjects.
CONCLUSIONS: Rhinovirus infection induces MIC molecules in respiratory epithelial cells in vitro and in vivo. Induction of soluble MICB molecules is impaired in asthmatics, suggesting these molecules may have a role in the antiviral immune response to rhinovirus infections. PMID: 24556715 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Telcian AG, Zdrenghea MT, Caramori G, Laza-Stanca V, Message SD, Kebadze T, Kon OM, Groh V, Papi A, Johnston SL, Mallia P, Stanciu LA Tags: Chest Source Type: research
Spirometric and gas transfer discordance in alpha-1-antitrypsin deficiency; patient characteristics and progression.
Abstract ABSTRACT (N=212) Phenotypic differences in physiological, radiological and clinical characteristics are increasingly recognised in COPD. The factors associated with alpha-1-antitrypsin deficiency (A1AD) physiological phenotypes and how they progress with time have yet to be explained.530 PiZZ A1AD patients were studied; 255 of whom had ≥3 years data for longitudinal analysis. Patients were categorized into 4 groups using lower limits of normal for Kco and post-bronchodilator FEV1/FVC ratio. Group comparisons were undertaken for demographic, clinical, physiological, health status, survival and CT data.Gro...
Source: Chest - February 20, 2014 Category: Respiratory Medicine Authors: Stockley RA, Ward H, Turner AM Tags: Chest Source Type: research
Psychroglaciecola arctica gen. nov., sp.nov., isolated from Arctic glacial foreland soil.
Abstract A novel pink-pigmented, facultatively methylotrophic strain, designated M6-76T, was isolated from glacial foreland soil near Ny-Alesund, Svalbard Archipelago, Norway. The cells were rod-shaped, Gram-negative and aerobic. Growth occurred at 4-28 (optimum 18) and at pH 5-8 (optimum pH 7). Strain M6-76T was rod-shaped (0.4-0.7 x 0.8-2.0 μm) and was motile by a single polar flagellum. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain M6-76T belonged to the family Methylobacteriaceae. The 16S rRNA gene sequence of this strain showed 94.6%, 94.0% and 93.9% sequence similarity to those...
Source: International Journal of Systematic and Evolutionary Microbiology - February 20, 2014 Category: Microbiology Authors: Qu Z, Jiang F, Chang X, Qiu X, Ren L, Fang C, Peng F Tags: Int J Syst Evol Microbiol Source Type: research
Taibaiella chishuiensis sp. nov., isolated from fresh water of the Chishui River in Maotai Town, China.
Abstract A Gram-negative, strictly aerobic, non-motile and rod-shaped bacterial strain, AY17T, was isolated from Chishui River in Guizhou Province, Southwest China. Strain AY17T grew optimally at pH 7.0 and 20 °C. Flexirubin-type pigments were produced. 16S rRNA gene sequence analysis indicated that strain AY17T belonged to the family Chitinophagaceae within the phylum Bacteroidetes; the closest phylogenetic relative was Taibaiella smilacinae PTJT-5T (95.3% gene sequence similarity). The DNA G+C content was 49.5 mol%. Strain AY17T included MK-7 as the predominant respiratory quinone and phosphatidylethanolamine as...
Source: International Journal of Systematic and Evolutionary Microbiology - February 20, 2014 Category: Microbiology Authors: Tan X, Zhang RG, Meng TY, Liang HZ, Lv J Tags: Int J Syst Evol Microbiol Source Type: research
Paenibacillus shirakamiensis sp. nov. isolated from the trunk surface of a Japanese oak (Quercus crispula) tree.
Abstract A novel bacterial strain designated P-1(T) was isolated from the trunk surface of a Japanese oak (Quercus crispula) tree growing in the Shirakami Mountains in Japan. Cells of strain P-1(T) were, Gram-stain-negative, 0.8 x 2-5 μm rods, ellipsoidal endospore-forming, aerobic, slightly acidophilic, and motile by means of peritrichous flagella. Various carbohydrates could be used as growth substrates, but none of the organic acids tested were used. The major cellular fatty acid was anteiso-C15:0, which accounted for 64.2% of the total fatty acids. The major respiratory quinone was menaquinone-7 (MK-7). Strain...
Source: International Journal of Systematic and Evolutionary Microbiology - February 20, 2014 Category: Microbiology Authors: Tonouchi A, Tazawa D, Fujita T Tags: Int J Syst Evol Microbiol Source Type: research
Individuals With Unilateral Vestibular Damage--Examination and Treatment With Focus on the Musculoskeletal System: A Case Series.
DiscussionThe recovery process is possibly influenced by self-inflicted rigid body movements and behaviour strategies that prevent compensation. By addressing physical dysfunctions and enhancing body awareness directly, and dizziness indirectly, it may be possible to break a self-sustaining circle of dizziness and musculoskeletal problems in patients with UVH. Considering the body as a functional unit and including both the musculoskeletal and vestibular systems in the examination and treatment may be important. PMID: 24557651 [PubMed - as supplied by publisher] (Source: Physical Therapy)
Source: Physical Therapy - February 20, 2014 Category: Physiotherapy Authors: Wilhelmsen K, Kvåle A Tags: Phys Ther Source Type: research
Versatile Roles of Plant NADPH Oxidases And Emerging Concepts.
Abstract NADPH oxidase (NOX) is a key player in the network of reactive oxygen species (ROS) producing enzymes. It catalyzes the production of superoxide (O2(-)), that in turn regulate a wide range of biological functions in a broad range of organisms. Plant Noxes are known as Respiratory burst oxidase homologs (Rbohs) and are homologs of catalytic subunit of mammalian phagocyte gp91(phox). They are unique among other ROS producing mechanisms in plants as they integrate different signal transduction pathways in plants. In recent years, there has been addition of knowledge on various aspects related to its structure...
Source: Biotechnology Advances - February 20, 2014 Category: Biotechnology Authors: Kaur G, Sharma A, Guruprasad K, Pati PK Tags: Biotechnol Adv Source Type: research
Heart rate variability in patients with severe chronic obstructive pulmonary disease in a home care program.
CONCLUSION: AECOPD patients exhibited signs of increased autonomic activity compared with stable COPD. PMID: 24561881 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - February 20, 2014 Category: Medical Equipment Authors: Zamarrón C, Lado MJ, Teijeiro T, Morete E, Vila XA, Lamas PF Tags: Technol Health Care Source Type: research
Mid-ventilation based PTV margins in Stereotactic Body Radiotherapy (SBRT): A clinical evaluation.
CONCLUSIONS: Using the MidV approach combined with online image guidance an excellent LC of 98% was established with SBRT. This provides clinical support that incorporating respiratory motion into the PTV margin is a safe approach. PMID: 24560765 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - February 20, 2014 Category: Radiology Authors: Peulen H, Belderbos J, Rossi M, Sonke JJ Tags: Radiother Oncol Source Type: research
Complications associated with laparoscopic adrenalectomy: Description and standardized assessment.
CONCLUSIONS: Standardized criteria of surgical complications are necessary. Standardization is possible by combined application of two tools. We believe that this evaluation concept of the surgery morbidity must be used systematically in order to achieve a new standard refined, concise and comparative for reports of adverse perioperative events. PMID: 24561053 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - February 20, 2014 Category: Urology & Nephrology Authors: Castillo OA, Rodríguez-Carlin A, López-Vallejo J, Borgna V Tags: Actas Urol Esp Source Type: research
Severe multiorganic flare of systemic lupus erythematosus successfully treated with rituximab and cyclophosphamide avoiding high doses of prednisone.
We report a case of a young woman with SLE, suffering from acute pancreatitis and diffuse alveolar haemorrhage, who was successfully treated with pulse methyl-prednisolone, hydroxychloroquine, cyclophosphamide and rituximab, combined with medium doses of prednisone. PMID: 24531426 [PubMed - in process] (Source: Lupus)
Source: Lupus - February 19, 2014 Category: Rheumatology Authors: Gonzalez-Echavarri C, Pernas B, Ugarte A, Ruiz-Irastorza G Tags: Lupus Source Type: research
The Impact of Lifestyle Behaviors on the Acquisition of Pandemic (H1N1) Influenza Infection: A Case-Control Study.
Conclusion: A current smoking status and a history of frequent colds were associated with an increased risk of acquiring H1N1 infection. PMID: 24532513 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 19, 2014 Category: Universities & Medical Training Authors: Choi SM, Jeong YJ, Park JS, Kang HJ, Lee YJ, Park SS, Lim HJ, Chung HS, Lee CH Tags: Yonsei Med J Source Type: research
Incidences of Serious Infections and Tuberculosis among Patients Receiving Anti-Tumor Necrosis Factor-α Therapy.
Conclusion: Serious infections with anti-TNF-α therapy were uncommon among tertiary hospitals in Korea; TB was the second most frequent infection. Nevertheless, there were no TB reactivations after anti-TB chemoprophylaxis. Accordingly, physicians should be aware of TB in subjects undergoing anti-TNF-α therapy, especially in countries with a high prevalence of TB. PMID: 24532516 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - February 19, 2014 Category: Universities & Medical Training Authors: Yoo IK, Choung RS, Hyun JJ, Kim SY, Jung SW, Koo JS, Lee SW, Choi JH, Kim H, Lee HS, Keum B, Kim ES, Jeen YT Tags: Yonsei Med J Source Type: research
Dexmedetomidine for rigid bronchoscopy in an infant with tracheal web after ventricular septal defect patch repair.
We report herein successful rigid bronchoscopy with preserved spontaneous breathing of a 54-day-old infant with tracheal web associated with previous ventricular septal defect (VSD) repair. We considered the use of dexmedetomidine in conjunction with intermittent ketamine from the following three clinical aspects. First, this infant was suffering from respiratory distress with chest retraction, the cause of which was not revealed by a computerized scan of the neck and chest. Second, the patient was scheduled for rigid bronchoscopy, which is accompanied by brief but strong stimulation. Third, this infant underwent congenita...
Source: Yonsei Medical Journal - February 19, 2014 Category: Universities & Medical Training Authors: Lee JS, Park SJ, Min KT Tags: Yonsei Med J Source Type: research
[In Process Citation].
PMID: 24527508 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - February 19, 2014 Category: Respiratory Medicine Authors: Skoczyński S Tags: Pneumonol Alergol Pol Source Type: research
[In Process Citation].
PMID: 24527507 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - February 19, 2014 Category: Respiratory Medicine Authors: Królikowski K, Domagała-Kulawik J Tags: Pneumonol Alergol Pol Source Type: research
Type I Chiari malformation presenting central sleep apnea
Abstract: Sleep apnea is a rare but a well-known clinical feature of type I Chiari malformation. It may be obstructive or central in nature. Sleep apnea in patients with type I Chiari malformation rarely presents without accompanying neurological signs or symptoms. We here report a case of a 10-year-old girl who presented with central sleep apnea without any other neurological signs but was ultimately diagnosed with type I Chiari malformation. The patient initially showed mild improvement in symptoms after administration of an acetazolamide. Finally, posterior fossa decompression dramatically improved her respiratory statu...
Source: Auris, Nasus, Larynx - February 19, 2014 Category: ENT & OMF Authors: Takuro Kitamura, Soichiro Miyazaki, Hiroshi Kadotani, Takashi Kanemura, Masako Okawa, Toshihiko Tanaka, Ichiro Komada, Taketo Hatano, Hideaki Suzuki Tags: Case Reports Source Type: research
Response to pneumococcal vaccination in Mannose‐binding lectin deficient adults with recurrent respiratory tract infections
In conclusion, our study suggests that MBL‐deficient adults with RRTI have a response to a pneumococcal capsular polysaccharide vaccine comparable with MBL‐sufficient patients. Moreover, we didn't find a clear clinical role of MBL‐deficiency in adults with RRTI. As MBL‐deficiency is associated with an increased susceptibility to pneumococcal infections, pneumococcal vaccination might be protective in MBL‐deficient patients with RRTI. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - February 19, 2014 Category: Allergy & Immunology Authors: Diana A. Kessel, Thijs W. Hoffman, Heleen Velzen‐Blad, Pieter Zanen, Ger T. Rijkers, Jan C. Grutters Tags: Original Article Source Type: research
Sleep respiratory disturbances and arousals at moderate altitude have overlapping electroencephalogram spectral signatures
This study employs spectral analysis to investigate the impact of respiratory disturbances (central/obstructive apnea and hypopnea or periodic breathing) at moderate altitude on the sleep electroencephalogram (EEG) and to compare EEG changes resulting from respiratory disturbances and arousals. Data were collected from 51 healthy male subjects who spent 1 night at moderate altitude (2590 m). Power density spectra of Stage 2 sleep were calculated in a subset (20) of these participants with sufficient artefact‐free data for (a) epochs with respiratory events without an accompanying arousal, (b) epochs containing an arous...
Source: Journal of Sleep Research - February 19, 2014 Category: Neurology Authors: Katrin Stadelmann, Tsogyal D. Latshang, Leila Tarokh, Christian M. Lo Cascio, Noemi Tesler, Anne‐Christin Stoewhas, Malcolm Kohler, Konrad E. Bloch, Reto Huber, Peter Achermann Tags: Regular Research Paper Source Type: research
All lesions great and small, part 2. Diagnostic cytology in veterinary medicine
This is the second in a two‐part review of diagnostic cytopathology in veterinary medicine. As in human medicine, cytopathology is a minimally invasive, rapid, and cost‐effective diagnostic modality with broad utilization. In this second part, the diagnostic applications of cytology in respiratory, gastrointestinal, genitourinary, endocrine, ocular, and central nervous system tissues are discussed with a section describing fluid analysis in veterinary medicine. As noted in the previous manuscript, which characterized the cytology of the skin/subcutis, musculoskeletal, and lymphoid tissues, the interpretation of veterin...
Source: Diagnostic Cytopathology - February 19, 2014 Category: Pathology Authors: Leslie C. Sharkey, Davis M. Seelig, Jed Overmann Tags: Timely Reviews Source Type: research
Cytodiagnostic aspects of lung adenocarcinoma manifesting with micropapillary pattern in sputum
The micropapillary pattern of lung adenocarcinoma was discussed in the 2004 World Health Organization classification and is now proposed as a distinct pattern in the new International Multidisciplinary Classification of Lung Adenocarcinoma Guidelines. The micropapillary pattern is histologically characterized by papillary tufts lacking a central fibrovascular core and is associated with an unfavorable prognosis. Herein, we report the cytological features of lung adenocarcinoma with the micropapillary pattern in a sputum specimen. A 75‐year‐old woman presented with a productive cough, blood‐tinged sputum, and some sym...
Source: Diagnostic Cytopathology - February 19, 2014 Category: Pathology Authors: Nien‐Yi Chang, John Wang, Cheng‐Ching Lin, Su‐Wey Chen Tags: Special Contribution: DIAGNOSTIC DILEMMA Source Type: research
Development and validation of the Newcastle laryngeal hypersensitivity questionnaire
Conclusion: The Newcastle Laryngeal Hypersensitivity Questionnaire is a simple, non-invasive tool to measure laryngeal paraesthesia in patients with laryngeal conditions such as chronic cough, paradoxical vocal fold movement(vocal cord dysfunction), muscle tension dysphonia, and globus pharyngeus. It can successfully differentiate patients from healthy controls and measure change following intervention. It is a promising tool for use in clinical research and practice. (Source: Cough)
Source: Cough - February 19, 2014 Category: Respiratory Medicine Authors: Anne VertiganSarah BonePeter Gibson Source Type: research
Predictors of expiratory flow limitation measured by forced oscillation technique in COPD
Conclusions: EFL measured by FOT is a global measure of COPD that has separable etiologies and is useful for evaluating the disease condition. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 19, 2014 Category: Respiratory Medicine Authors: Masashi MikamoToshihiro ShiraiKazutaka MoriYuichiro ShishidoTakefumi AkitaSatoru MoritaKazuhiro AsadaMasato FujiiTakafumi Suda Source Type: research
Adapted Treatment of Epstein–Barr Virus Infection to Prevent Posttransplant Lymphoproliferative Disorder After Heart Transplantation
Up to 35% of posttransplant lymphoproliferative disorder (PTLD) cases occur within 1 year of transplantation, and over 50% are associated with Epstein–Barr virus (EBV). EBV primary infection and reactivation are PTLD predictive factors, but there is no consensus for their treatment. We conducted a prospective single‐center study on 299 consecutive heart‐transplant patients treated with the same immunosuppressive regimen and monitored by repetitive EBV viral‐load measurements and endomyocardial biopsies to detect graft rejection. Immunosuppression was tapered on EBV reactivation with EBV viral loads >105 copies...
Source: American Journal of Transplantation - February 19, 2014 Category: Transplant Surgery Authors: S. Choquet, S. Varnous, C. Deback, J. L. Golmard, V. Leblond Tags: Original Article Source Type: research
[Current concepts of augmented spontaneous breathing : New modes of effort-adapted weaning.]
Abstract The use of augmented spontaneous breathing is an important component in a bundle concept of weaning from mechanical ventilation as it was demonstrated that controlled ventilation with diaphragmatic underuse induces rapid muscle atrophy and impairs successful weaning. On the other hand spontaneous breathing is often associated with disturbed patient-ventilator interaction resulting in asynchrony (e.g. ineffective triggering, early termination of inspiration and overflow or underflow). It was shown that asynchrony can impair gas exchange, increase work of breathing and enhance deleterious aspects of mechanic...
Source: Der Anaesthesist - February 19, 2014 Category: Anesthesiology Authors: Bein T Tags: Anaesthesist Source Type: research
Haplotypes of FcγRIIa and FcγRIIIb Polymorphic Variants Influence IgG-Mediated Responses in Neutrophils.
Abstract Human blood neutrophils normally express two FcγRs (FcγRIIa and FcγRIIIb) that, upon multivalent binding of IgG in immune complexes or on opsonized targets, mediate responses such as phagocytosis, Ab-dependent cellular cytotoxicity, and respiratory burst. Allelic variants have been described for both FcγRIIa (131H/R) and FcγRIIIb (NA1/NA2/SH), with different binding affinity for IgG subclasses. Because neither of these variants acts alone, we have set out to systematically analyze in a large cohort of healthy FCGR2/3-genotyped volunteers how the different haplotypes of neutrophil FcγRs functionally i...
Source: Journal of Immunology - February 19, 2014 Category: Allergy & Immunology Authors: van der Heijden J, Nagelkerke S, Zhao X, Geissler J, Rispens T, van den Berg TK, Kuijpers TW Tags: J Immunol Source Type: research
Intranasal administration of retinyl palmitate with a respiratory virus vaccine corrects impaired mucosal IgA response in the vitamin A deficient host.
Abstract Our previous studies showed that intranasal vaccination of vitamin A deficient (VAD) mice failed to induce normal levels of upper respiratory tract IgA, a first line of defense against respiratory virus infection. Here we demonstrate that the impaired responses in VAD animals are corrected by a single intranasal application of retinyl palmitate with the vaccine. Results encourage the clinical testing of intranasal vitamin A supplements to improve protection against respiratory viral disease in VAD populations. PMID: 24554696 [PubMed - as supplied by publisher] (Source: Clinical and Vaccine Immunology)
Source: Clinical and Vaccine Immunology - February 19, 2014 Category: Allergy & Immunology Authors: Surman SL, Jones BG, Rudraraju R, Sealy RE, Hurwitz JL Tags: Clin Vaccine Immunol Source Type: research
Allogeneic blood transfusions and postoperative infections after total hip or knee arthroplasty.
CONCLUSIONS: The rates of any infection, lower or upper respiratory tract and lung infection, and wound inflammation or infection were significantly increased after elective total hip or total knee arthroplasty in patients receiving allogeneic blood transfusion compared with those receiving autologous blood transfusion or no blood transfusion. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence. PMID: 24553882 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)
Source: The Journal of Bone and Joint Surgery. American volume - February 19, 2014 Category: Orthopaedics Authors: Friedman R, Homering M, Holberg G, Berkowitz SD Tags: J Bone Joint Surg Am Source Type: research