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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Standardizing the analysis of physical activity in patients with COPD following a pulmonary rehabilitation program.
CONCLUSIONS Changes in PA following pulmonary rehabilitation are best measured for 4 weekdays, including only days with at least 8 hours of wearing time (during waking hours) and considering the difference in daylight time as a covariate into the analysis. CLINICAL TRIAL REGISTRATION; NCT00948623. PMID: 24603844 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 6, 2014 Category: Respiratory Medicine Authors: Demeyer H, Burtin C, Van Remoortel H, Hornikx M, Langer D, Decramer M, Gosselink R, Janssens W, Troosters T Tags: Chest Source Type: research

Chronic pleuropulmonary fibrosis and elastosis of aged donkeys - similarities to human pleuroparenchymal fibroelastosis (PPFE).
CONCLUSIONS: Many cases of DPF share key pathological and imaging features with human PPFE, a rare interstitial pneumonia. Consequently, further study of DPF may help elucidate the aetiopathogenesis of human PPFE. PMID: 24603773 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 6, 2014 Category: Respiratory Medicine Authors: Miele A, Dhaliwal K, Du Toit N, Murchison JT, Dhaliwal C, Brooks H, Smith SH, Hirani N, Schwarz T, Haslett C, Wallace WA, McGorum B Tags: Chest Source Type: research

Genetic diversity and Phylogenetic analysis of porcine reproductive and respiratory syndrome virus isolates in East China.
In this study, 44 PRRSV positive cases obtained from different provinces of China were sequenced and analyzed. Comparative analysis of partial isolates based on nsp2 sequences revealed that highly pathogenic PRRSV were the dominant viruses in China from 2008 to 2010 and some novel strains with an extra deletion of 19 aa. Phylogenetic analysis based on the GP5 genes showed that the PRRSV isolates from 1996 to 2010 had a great variation and the North American genotype was further divided into six subgenotypes. No apparent relationship between the heterogeneity and the geographic origin of isolates was observed. The 44 isolat...
Source: Infection, Genetics and Evolution - March 6, 2014 Category: Genetics & Stem Cells Authors: Wang X, He K, Zhang W, Zhou Z, Mao A, Yu Z Tags: Infect Genet Evol Source Type: research

Prevalence of asthma and respiratory symptoms in 15–17 year-old Greek-Cypriots by proximity of their community of residence to power plants: Cyprus 2006–07
Conclusions: Higher prevalence of active asthma was observed in the vicinity of power plants, with no evidence of a distance-response relationship. With less than 5% of this age-group residing in close proximity to power plants, this corresponds to a small fraction of active asthma attributable to power plant emissions. (Source: Public Health)
Source: Public Health - March 6, 2014 Category: Global & Universal Authors: N. Middleton, O. Kolokotroni, D. Lamnisos, P. Koutrakis, P.K. Yiallouros Tags: Original Research Papers Source Type: research

Population pharmacokinetics of olprinone in healthy male volunteers
Kunisawa T, Kasai H, Suda M, Yoshimura M, Sugawara A, Izumi Y, Iida T, Kurosawa A, Iwasaki H (Source: International Journal of COPD)
Source: International Journal of COPD - March 5, 2014 Category: Respiratory Medicine Source Type: research

Extracorporeal membrane oxygenation in diffuse alveolar hemorrhage secondary to systemic lupus erythematosus.
We report two adult cases where extracorporeal membrane oxygenation (ECMO) was used as rescue therapy for severe respiratory failure in this setting. We discuss the risk related to coagulation disturbance and the need for the circuit anticoagulation in this particular setting. We also briefly discuss the clinical problem of lack of knowledge on the bioavailability of the immunosuppressive treatment with the use of ECMO. We think that ECMO should be used as rescue therapy in patients with DAH caused by SLE, but strategies for anticoagulation require further precision. PMID: 24578757 [PubMed] (Source: Clin Med Res)
Source: Clin Med Res - March 5, 2014 Category: Research Authors: Claudio CP, Charbonney E, Durand M, Kolan C, Laskine M Tags: J Clin Med Res Source Type: research

Pilot observational study on haemodynamic changes after surfactant administration in preterm newborns with respiratory distress syndrome
Background: Surfactant treatment reduces respiratory morbidity and mortality in preterm infants. Data on its haemodynamic consequences are conflicting. The aim was to characterise the haemodynamic effects of surfactant treatment on cardiac function in preterm newborns with respiratory distress syndrome (RDS). Methods: Preterm infants (gestational age (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - March 5, 2014 Category: Pediatrics Authors: Francesca VitaliSilvia GallettiArianna AcetiGiulia AquilanoMarianna FabiAnna BalducciGiacomo Faldella Source Type: research

Massive cement pulmonary embolism during percutaneous vertebroplasty
A 71-year-old woman was admitted to hospital after a car crash and diagnosed with L1 vertebral body fracture. A percutaneous transpedicular lumbar fixation using polymethylmethacrylate (PMMA) cement was decided. During the procedure, a massive PMMA cement leakage into the paravertebral venous system was observed. Hypotension, acute respiratory distress and refractory hypoxaemia were rapidly manifested. A cement pulmonary embolism was suspected and an unenhanced CT performed. A large collection of PMMA fragments were distinguished in the right pulmonary artery (RPA) and lobar branches (figure 1A). A huge PMMA piece was seen...
Source: Heart - March 5, 2014 Category: Cardiology Authors: Arnaiz-Garcia, M. E., Dalmau-Sorli, M. J., Gonzalez-Santos, J. M. Tags: Miscellanea Source Type: research

Secondary pulmonary alveolar proteinosis complicating myelodysplastic syndrome results in worsening of prognosis: a retrospective cohort study in Japan
Conclusion: Development of sPAP during the course of MDS may be an important adverse risk factor in prognosis of patients with mild MDS. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - March 5, 2014 Category: Respiratory Medicine Authors: Haruyuki IshiiJohn SeymourRyushi TazawaYoshikazu InoueNaoyuki UchidaAya NishidaYoshihito KogureTakeshi SarayaKeisuke TomiiToshinori TakadaYuko ItohMasayuki HojoToshio IchiwataHajime GotoKoh Nakata Source Type: research

Resource use by patients hospitalized with community-acquired pneumonia in Europe: analysis of the REACH study
Conclusions: Initial antibiotic treatment modification in patients with CAP is common and is associated with considerable additional resource use. Reassessment of optimal management paradigms for patients hospitalized with CAP may be warranted. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - March 5, 2014 Category: Respiratory Medicine Authors: Helmut OstermannJavier GarauJesús MedinaEsther PascualKyle McBrideFrancesco Blasi Source Type: research

BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6
Conclusion: We speculate that the pathogenesis of our case may be a hypersensitive reaction to the proteic component of BCG entering the lung and pleural space, which is different from the etiology of the common type of HP. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - March 5, 2014 Category: Respiratory Medicine Authors: Makoto TobiumeTsutomu ShinoharaTakahira KunoShinji MukaiKeishi NaruseNobuo HatakeyamaFumitaka Ogushi Source Type: research

Risk over time and risk factors of intraoperative respiratory events: a historical cohort study of 14,153 children
Conclusions: IRE risk was highest in the induction and early maintenance period. Assisted ventilation via facemask or LMA and desflurane anesthesia were anesthesia-related risk factors for laryngospasm. Therefore, anesthesiologists should pay more attention during the induction and early maintenance period especially when certain airway devices incorporated with assisted ventilation or desflurane are used.Number of words: (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - March 5, 2014 Category: Anesthesiology Authors: Maliwan OofuvongAlan GeaterVirasakdi ChongsuvivatwongNgamjit PattaravitKanjana Nuanjun Source Type: research

Diagnosis and conservative management of late tracheotomy complications in the chronic ventilator‐dependent patient
Conclusions: In non‐surgical candidates, insertion of a longer tube is a conservative and feasible long‐term treatment. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - March 5, 2014 Category: ENT & OMF Authors: Ophir Ilan, Menachem Gross, Yacov Zaltzman, Ady Sasson, Esther‐Lee Marcus Tags: Original Article Source Type: research

Parainfluenza Virus Lower Respiratory Tract Disease after Hematopoietic Cell Transplantation: Viral Detection in the Lung Predicts Outcome.
Conclusions. PIV LRD with viral detection in lungs (proven/probable LRD) was associated with worse outcomes compared with that with viral detection in upper respiratory samples alone (possible LRD). This new classification should impact clinical trial design and permit comparability of results among centers. PMID: 24599766 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - March 5, 2014 Category: Cancer & Oncology Authors: Seo S, Xie H, Campbell AP, Kuypers JM, Leisenring WM, Englund JA, Boeckh M Tags: Clin Infect Dis Source Type: research

Diagnostic accuracy of nitric oxide measurements to detect Primary Ciliary Dyskinesia
ConclusionsnNOplat, nNOtid and FENO measurements overlap between PCD and disease controls. Sensitivity is comparable for the 3 tests. Applying composite scores slightly improves diagnostic accuracy. Given the less than 90% test sensitivity, PCD should be considered in patients with intermediate results.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - March 5, 2014 Category: Journals (General) Authors: Mieke Boon, Isabelle Meyts, Marijke Proesmans, Francois L. Vermeulen, Mark Jorissen, Kris Boeck Tags: Original Paper Source Type: research

Walking may help reduce chances of hospital admission for severe respiratory diseases.
Authors: Abstract People with chronic obstructive pulmonary disease (COPD) who maintain moderate or high levels of exercise have a reduced risk of hospital stay compared with those who take little exercise or become more sedentary over time, suggests a Spanish study. PMID: 24593079 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - March 5, 2014 Category: Nursing Tags: Nurs Stand Source Type: research

The past, present and future of stem cell clinical trials for ALS.
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is characterized by progressive degeneration of motor neurons in the cortex, brainstem and spinal cord. This leads to paralysis, respiratory insufficiency and death within an average of 3 to 5years from disease onset. While the genetics of ALS are becoming more understood in familial cases, the mechanisms underlying disease pathology remain unclear and there are no effective treatment options. Without understanding what causes ALS it is difficult to design treatments. However, in recent years stem cell transplantation ther...
Source: Experimental Neurology - March 5, 2014 Category: Neurology Authors: Thomsen GM, Gowing G, Svendsen S, Svendsen CN Tags: Exp Neurol Source Type: research

Construction of a Single Chain Variable Fragment Antibody (scFv) against Tetrodotoxin (TTX) and its Interaction with TTX.
Abstract Tetrodotoxin (TTX) is a small molecular weight neurotoxin that occludes voltage-gated sodium channels in nerve and muscle tissue, resulting in respiratory paralysis and death. A high affinity antibody that can neutralize the toxicity of TTX is still lacking, so it is very important to prepare an antibody for TTX therapy and detection. In the present study, a chemical method was used to prepare the tetrodotoxin complete antigen, and a small amount,repeatedly immunity way was carried to immunize 4 mice. The amplified genes encoding monoclonal antibodies against TTX were used to construct the phage display ...
Source: Toxicon - March 5, 2014 Category: Toxicology Authors: Wang R, Huang A, Liu L, Xiang S, Li X, Ling S, Wang L, Lu T, Wang S Tags: Toxicon Source Type: research

Evaluation of Accuracy of FAD-GDH- and Mutant Q-GDH-based Blood Glucose Monitors in Multi-Patient Populations.
CONCLUSIONS: Analytical results prove the GDH-based monitors tolerate a broad BG concentration range, are oxygen independent, have BG specificity, have minimal interference from hematocrit. The GDH-based monitors are reliable for multi-patient use. PMID: 24613515 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - March 5, 2014 Category: Chemistry Authors: Huang TY, Chang HW, Tsao MF, Chuang SM, Ni CC, Sue JW, Lin HC, Hsu CT Tags: Clin Chim Acta Source Type: research

Validation and comparison of different end point and real time RT-PCR assays for detection and genotyping of porcine reproductive and respiratory syndrome virus.
In this study two real time RT-PCR based on different chemistry analysis (TaqMan Probes and SYBR Green) have been developed and validated before comparison to an end point two-step RT-PCR validated previously. All assays were aimed at discrimination between PRRSV genotypes. Furthermore, an exogenous internal control (IC) system had also been implemented in qRT-PCR. A rigorous analytical validation, executed on infected cell cultures and serum, demonstrated good sensitivity, specificity and repeatability. In particular RT-PCR was exceptionally sensitive and could detect a viral titre in the order of a magnitude of 1 copies/...
Source: Journal of Virological Methods - March 5, 2014 Category: Virology Authors: Drigo M, Franzo G, Belfanti I, Martini M, Mondin A, Ceglie L Tags: J Virol Methods Source Type: research

Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital
Conclusions: Community acquired severe sepsis is common. Initial clinical aetiology is often revised. Compliance with recommendations for empirical antimicrobial treatment is lowest in elderly patients. Our results emphasizes that quick identification of correct source of infection, proper sampling for microbiological analyses, and fast administration of adequate antimicrobial agents are crucial points in the management of severe sepsis. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Siri Tandberg NygårdNina LangelandHans K FlaattenRune FanebustOddbjørn HaugenSteinar Skrede Source Type: research

An atypical winter outbreak of hand, foot, and mouth disease associated with human enterovirus 71, 2010
Conclusion: This outbreak of HMFD was caused by EV71 in an atypical winter. EV71 strains associated with this outbreak represented three separate chains of transmission. Substitution at amino acid position 145 of the VP1 region of EV71 might be an important virulence marker for severe cases. These findings suggest that continued surveillance for EV71 variants has the potential to greatly impact HFMD prevention and control. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 4, 2014 Category: Infectious Diseases Authors: Nan LiuJing XieXiaoli QiuLeili JiaZhihao WuYuhua MaZhongqiang WangPeng LiXingbin RenRongzhang HaoLigui WangYong WangShaofu QiuHongbin Song Source Type: research

Unplanned medication discontinuation as a potential pharmacovigilance signal: a nested young person cohort study
Conclusions: Identification of unplanned medication discontinuation using large primary care datasets may be a useful tool for pharmacovigilance signal generation and detection of potential ADRs in children and young people. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - March 4, 2014 Category: Epidemiology Authors: Angela Peichen SunBradley KirbyCorri BlackPeter John HelmsMarion BennieJames Stuart McLay Source Type: research

Genomic variation in macrophage-cultured European porcine reproductive and respiratory syndrome virus Olot/91 revealed using ultra-deep next generation sequencing
Conclusion: Using an ultra-deep sequencing methodology, the complete genome of Olot/91 was constructed without any prior knowledge of the sequence. Rare variants that constitute minor fractions of the heterogeneous PRRSV population could successfully be detected to allow further exploration of microevolutionary events. (Source: Virology Journal)
Source: Virology Journal - March 4, 2014 Category: Virology Authors: Zen LuAlexander BrownAlison WilsonJay CalvertMonica BalaschPablo Fuentes-UtrillaJulia LoecherbachFrances TurnerRichard TalbotAlan ArchibaldTahar Ait-Ali Source Type: research

Phenotyping community-acquired pneumonia according to the presence of acute respiratory failure and severe sepsis
Conclusions: The identification of ARF and SS on hospital admission can help physicians in classifying CAP patients into three different clinical phenotypes. (Source: Respiratory Research)
Source: Respiratory Research - March 4, 2014 Category: Respiratory Medicine Authors: Stefano AlibertiAnna Maria BrambillaJames ChalmersCatia CillonizJulio RamirezAngelo BignaminiElena PrinaEva PolverinoPaolo TarsiaAlberto PesciAntoni TorresFrancesco BlasiRoberto Cosentini Source Type: research

Veno‐venous extracorporeal membrane oxygenation in obese surgical patients with hypercapnic lung failure
ConclusionsECMO in obese patients is feasible and life saving. Therefore, a percutaneous cannulation remains feasible. The goals of the ECMO therapy include early spontaneous breathing, tracheotomy, rapid reduction of sedation and adequate analgesia. Rehabilitation includes nutritional therapy, as well as psychiatric therapy and bariatric surgery, as perspectives for the future. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - March 4, 2014 Category: Anesthesiology Authors: J. SWOL, D. BUCHWALD, M. DUDDA, J. STRAUCH, T. A. SCHILDHAUER Tags: Original Article Source Type: research

Effectiveness of an alcohol‐free essential oil‐containing mouthwash in institutionalised elders receiving long‐term care: a feasibility study
ConclusionThis pilot study shows that, if sufficient logistical and financial resources are available, it is feasible to conduct randomised clinical trials in a seniors' facility. The use of an AF‐EOMW to improve oral hygiene in seniors was not found to be superior to tap water. However, larger controlled clinical studies are needed to confirm these results. (Source: Gerodontology)
Source: Gerodontology - March 4, 2014 Category: Dentistry Authors: Elsy Chalhoub, Elham Emami, Maria Freijé, Daniel Kandelman, Melanie Campese, Annie St‐Georges, René Voyer, Pierre Rompré, Jean Barbeau, Annie Leduc, Robert Durand Tags: Original Article Source Type: research

Chronic Functional Bowel Syndrome Enhances Gut-Brain Axis Dysfunction, Neuroinflammation, Cognitive Impairment, and Vulnerability to Dementia.
Abstract The irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder world wide that lasts for decades. The human gut harbors a diverse population of microbial organisms which is symbiotic and important for well being. However, studies on conventional, germ-free, and obese animals have shown that alteration in normal commensal gut microbiota and an increase in pathogenic microbiota-termed "dysbiosis", impact gut function, homeostasis, and health. Diarrhea, constipation, visceral hypersensitivity, and abdominal pain arise in IBS from the gut-induced dysfunctional metabolic, immune, an...
Source: Neurochemical Research - March 4, 2014 Category: Neuroscience Authors: Daulatzai MA Tags: Neurochem Res Source Type: research

Computed Tomography and Cross-Sectional Anatomy of the Thorax of the Live Bottlenose Dolphin (Tursiops truncatus).
Abstract Pulmonary disease is one of the leading causes of cetacean morbidity and mortality in the wild and in managed collections. The purpose of this study was to present the computed tomographic (CT) appearance of the thorax of the live bottlenose dolphin (Tursiops truncatus) out-of-water and to describe the technical and logistical parameters involved in CT image acquisition in this species. Six thoracic CT evaluations of four conscious adult bottlenose dolphins were performed between April 2007 and May 2012. Animals were trained to slide out of the water onto foam pads and were transported in covered trucks to...
Source: Anatomical Record - March 4, 2014 Category: Anatomy Authors: Ivančić M, Solano M, Smith CR Tags: Anat Rec (Hoboken) Source Type: research

Effects of Periodontal Treatment on Lung Function and Exacerbation Frequency in Patients with Chronic Obstructive Pulmonary Disease and Chronic Periodontitis: A 2-Year Pilot Randomized Controlled Trial.
CONCLUSIONS: Our preliminary results from this pilot trial suggest that periodontal therapy in COPD patients with CP may improve lung function and decrease the frequency of COPD exacerbation. This article is protected by copyright. All rights reserved. PMID: 24593836 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - March 4, 2014 Category: Dentistry Authors: Zhou X, Han J, Liu Z, Song Y, Wang Z, Sun Z Tags: J Clin Periodontol Source Type: research

Pro-inflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress and dynamics.
In this study we evaluated the chronic effects of TNFα, IL-6 and IL-1β on adipocyte mitochondrial metabolism and morphology using the 3T3-L1 model cell system. TNFα treatment of cultured adipocytes led to significant changes in mitochondrial bioenergetics including increased proton leak, decreased membrane potential, increased basal respiration and decreased ATP turnover. In contrast, while IL-6 and IL-1β decreased maximal respiratory capacity, they had no effect on membrane potential and varied effects on ATP turnover, proton leak and basal respiration. Only TNFα treatment of 3T3-L1 cells led to an increase in oxidat...
Source: Am J Physiol Endocri... - March 4, 2014 Category: Endocrinology Authors: Hahn WS, Kuzmicic J, Burrill JS, Donoghue MA, Foncea R, Jensen MD, Lavandero S, Arriaga EA, Bernlohr DA Tags: Am J Physiol Endocrinol Metab Source Type: research

Traffic Related Air Pollution and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.
Conclusion: Higher levels of NO2 exposure were associated with greater RV mass and larger RV end-diastolic volume. PMID: 24593877 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 4, 2014 Category: Respiratory Medicine Authors: Leary PJ, Kaufman JD, Barr RG, Bluemke DA, Curl CL, Hough CL, Lima JA, Szpiro AA, Van Hee VC, Kawut SM Tags: Am J Respir Crit Care Med Source Type: research

Bacillus Calmette-Guérin and isoniazid preventive therapy protect contacts of tuberculosis patients.
Conclusions: These findings support the use of IPT in older child and young-adult household contacts, in addition to children <5 years. PMID: 24592878 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 4, 2014 Category: Respiratory Medicine Authors: Zelner JL, Murray MB, Becerra MC, Galea J, Lecca L, Calderon R, Yataco R, Contreras C, Zhang Z, Grenfell BT, Cohen T Tags: Am J Respir Crit Care Med Source Type: research

Z alpha-1 antitrypsin confers a pro-inflammatory phenotype that contributes to COPD.
Conclusions We show here that aggregation of intracellular mutant Z-AT invokes a specific deleterious cellular inflammatory phenotype in COPD. Oxidant-induced intracellular polymerization of Z-AT in epithelial cells causes ER stress, and promotes excess cytokine and cellular inflammation. This pathway is likely to contribute to the development of COPD in ZZ-AT homozygotes, and therefore merits further investigation. PMID: 24592811 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 4, 2014 Category: Respiratory Medicine Authors: Alam S, Li Z, Atkinson C, Jonigk D, Janciauskiene S, Mahadeva R Tags: Am J Respir Crit Care Med Source Type: research

Red cell distribution width: A new predictor for chronic thromboembolic pulmonary hypertension after pulmonary embolism.
This study is a retrospective cohort study. A total of 203 consecutive patients with acute PE were included. The RDW was higher in the CTEPH patients than the patients without CTEPH (17.04 ± 3.46, 14.64 ± 1.82, respectively, p = 0.015). RDW was also higher in the CTEPH patients at the time of diagnosis of CTEPH during follow-up compared with the baseline RDW level at the time of PE diagnosis (18.63 ± 3.58, 17.02 ± 3.59, respectively, p = 0.014). The optimal cutoff value of the RDW for predicting CTEPH was 14.65. The area under the curve of RDW for the prediction of CTEPH was 0.735 (95% confidence interval (CI): 0.600-0...
Source: Chronic Respiratory Disease - March 4, 2014 Category: Respiratory Medicine Authors: Abul Y, Ozsu S, Korkmaz A, Bulbul Y, Orem A, Ozlu T Tags: Chron Respir Dis Source Type: research

Genome-wide association and genomic prediction for host response to porcine reproductive and respiratory syndrome virus infection.
CONCLUSIONS: Traits associated with response to PRRSV infection in growing pigs are largely controlled by genomic regions with relatively small effects, with the exception of SSC4. Accuracies of EBV based on the SSC4 region were high compared to the rest of the genome. These results show that selection for the SSC4 region could potentially reduce the effects of PRRS in growing pigs, ultimately reducing the economic impact of this disease. PMID: 24592976 [PubMed - as supplied by publisher] (Source: Genet Sel Evol)
Source: Genet Sel Evol - March 4, 2014 Category: Genetics & Stem Cells Authors: Boddicker NJ, Bjorkquist A, Rowland RR, Lunney JK, Reecy JM, Dekkers JC Tags: Genet Sel Evol Source Type: research

Emotion dysregulation and dyadic conflict in depressed and typical adolescents: Evaluating concordance across psychophysiological and observational measures.
In this study, we evaluated concordance of physiological and observational measures of emotion dysregulation during interpersonal conflict, using a multilevel actor-partner interdependence model (APIM). Participants were 75 mother-daughter dyads, including 50 depressed adolescents with or without a history of self-injury, and 25 typically developing controls. Behavior dysregulation was operationalized as observed aversiveness during a conflict discussion, and physiological dysregulation was indexed by respiratory sinus arrhythmia (RSA). Results revealed different patterns of concordance for control versus depressed partici...
Source: Biological Psychology - March 4, 2014 Category: Psychiatry & Psychology Authors: Crowell SE, Baucom BR, Yaptangco M, Bride D, Hsiao R, McCauley E, Beauchaine TP Tags: Biol Psychol Source Type: research

Health risks caused by short term exposure to ultrafine particles generated by residential wood combustion: A case study of Temuco, Chile.
Abstract Temuco is one of the most highly wood smoke polluted cities in Chile; however, there is scarce evidence of respiratory morbidity due to fine particulate matter. We aimed to estimate the relationship between daily concentration of ultrafine particles (UFP), with an aerodynamic diameter ≤0.1μm, and outpatient visits for respiratory illness at medical care centers of Temuco, Chile, from August the 20th, 2009 to June the 30th, 2011. The Air Pollution Health Effects European Approach (APHEA2) protocol was followed, and a multivariate semi-parametric Poisson regression model was fitted with GAM techniques usi...
Source: Environment International - March 4, 2014 Category: Environmental Health Authors: Díaz-Robles LA, Fu JS, Vergara-Fernández A, Etcharren P, Schiappacasse LN, Reed GD, Silva MP Tags: Environ Int Source Type: research

Redox-driven regulation of microbial community morphogenesis.
Abstract During growth on surfaces, diverse microbial communities display topographies with captivating patterns. The quality and quantity of matrix excreted by resident cells play major roles in determining community architecture. Two current publications indicate that the cellular redox state and respiratory activity are important parameters affecting matrix output in the divergent bacteria Pseudomonas aeruginosa and Bacillus subtilis. These and related studies have identified regulatory proteins with the potential to respond to changes in redox state and respiratory electron transport and modulate the activity o...
Source: Current Opinion in Microbiology - March 4, 2014 Category: Microbiology Authors: Okegbe C, Price-Whelan A, Dietrich LE Tags: Curr Opin Microbiol Source Type: research

Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells.
Abstract Branching morphogenesis, the process by which cells or tissues generate tree-like networks that function to increases surface area or in contacting multiple targets, is a common developmental motif in multicellular organisms. We use Drosophila tracheal terminal cells, a component of the insect respiratory system, to investigate branching morphogenesis that occurs on the single cell level. Here, we show that the exocyst, a conserved protein complex that facilitates docking and tethering of vesicles at the plasma membrane, is required for terminal cell branch outgrowth. We find that exocyst-deficient termina...
Source: Developmental Biology - March 4, 2014 Category: Biology Authors: Jones TA, Nikolova LS, Schjelderup A, Metzstein MM Tags: Dev Biol Source Type: research

Tissue-Specific Loss of DARS2 Activates Stress Responses Independently of Respiratory Chain Deficiency in the Heart.
Abstract Adaptive stress responses activated upon mitochondrial dysfunction are assumed to arise in order to counteract respiratory chain deficiency. Here, we demonstrate that loss of DARS2 (mitochondrial aspartyl-tRNA synthetase) leads to the activation of various stress responses in a tissue-specific manner independently of respiratory chain deficiency. DARS2 depletion in heart and skeletal muscle leads to the severe deregulation of mitochondrial protein synthesis followed by a strong respiratory chain deficit in both tissues, yet the activation of adaptive responses is observed predominantly in cardiomyocytes. W...
Source: Cell Metabolism - March 4, 2014 Category: Cytology Authors: Dogan SA, Pujol C, Maiti P, Kukat A, Wang S, Hermans S, Senft K, Wibom R, Rugarli EI, Trifunovic A Tags: Cell Metab Source Type: research

The LINA Cohort: Cord Blood Eosinophil/Basophil Progenitors Predict Respiratory Outcomes in Early Infancy.
CONCLUSIONS: The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment. PMID: 24607604 [PubMed - as supplied by publisher] (Source: Clinical Immunology)
Source: Clinical Immunology - March 4, 2014 Category: Allergy & Immunology Authors: Junge KM, Hörnig F, Herberth G, Röder S, Kohajda T, Rolle-Kampczyk U, von Bergen M, Borte M, Simon JC, Heroux D, Denburg JA, Lehmann I Tags: Clin Immunol Source Type: research

Non-REM sleep EEG power distribution in fatigue and sleepiness
Conclusions: Slow wave activity presents as a crossroad of fatigue and sleepiness with, however, different spectral power band distributions during non-REM sleep. The homeostatic function of sleep might be compromised in CFS patients and could explain why, in contrast to sleepiness, fatigue does not resolve with sleep in these patients. The present findings thus contribute to the differentiation of both phenomena. (Source: Journal of Psychosomatic Research)
Source: Journal of Psychosomatic Research - March 4, 2014 Category: Psychiatry & Psychology Authors: Daniel Neu, Olivier Mairesse, Paul Verbanck, Paul Linkowski, Olivier Le Bon Tags: Original Articles Source Type: research

Vitamin D: a new anti‐infective agent?
Before the antibiotic era, treatment of tuberculosis patients was restricted to sun exposure in sanatoria. Years later, it was found that 1,25‐dihydroxyvitamin D3 stimulates production of cathelicidins, a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes. Cathelicidins serve a critical role in innate immune defense, which plays an important role in the suppression of Mycobacterium infections and other pathogens. It is believed that the increased incidence of the common cold and pneumonia during winter is related, in part, to decreased exposure to sunlight, resulting in a decreased ...
Source: Annals of the New York Academy of Sciences - March 4, 2014 Category: Science Authors: Elisabetta Borella, Gideon Nesher, Eitan Israeli, Yehuda Shoenfeld Tags: Original Article Source Type: research

Theravance aims for Q2 split into drug development, royalty companies
Theravance Inc. will split into two companies by the end of the second quarter, the company said Monday, in a separation that moves its revenue-producing drugs into one company and drug development in the other. The drug-development company will be backed by about $300 million, which South San Francisco-based Theravance (NASDAQ: THRX) said is enough to see it through milestone events over the next two to three years for a portfolio of respiratory and pain drugs. Theravance last year initially announced… (Source: Health Care:Pharmaceuticals headlines)
Source: Health Care:Pharmaceuticals headlines - March 3, 2014 Category: Pharmaceuticals Authors: Ron Leuty Source Type: research