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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Recent advances in mechanical ventilation in patients without acute respiratory distress syndrome.
Authors: Serpa Neto A, Filho RR, Rocha LL, Schultz MJ Abstract While being an essential part of general anesthesia for surgery and at times even a life-saving intervention in critically ill patients, mechanical ventilation has a strong potential to cause harm. Certain ventilation strategies could prevent, at least to some extent, the injury caused by this intervention. One essential element of so-called 'lung-protective' ventilation is the use of lower tidal volumes. It is uncertain whether higher levels of positive end-expiratory pressures have lung-protective properties as well. There are indications that too hig...
Source: F1000 Medicine Reports - January 14, 2015 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research

S1P signaling: new therapies and opportunities.
Authors: Gonzalez-Cabrera PJ, Brown S, Studer SM, Rosen H Abstract Development of sphingosine-1-phosphate receptor 1 (S1P1) modulators to dampen inflammation and its sequelae is becoming increasingly promising for treating medical conditions characterized by significant immunopathology. As shown by the non-selective S1P receptor modulator FTY720 (fingolimod [Gilenya(®)]) in the treatment of relapsing-remitting multiple sclerosis (MS), the ability to use S1P1 modulation to precisely block immune cell traffic-immunomodulation-while maintaining immunosurveillance, has opened therapeutic opportunities in various other...
Source: F1000 Medicine Reports - January 14, 2015 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research

Mycobacterium abscessus subsp abscessus lung disease: 'trouble ahead, trouble behind…'.
Authors: Griffith DE Abstract Mycobacterium abscessus subsp abscessus is the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria (NTM) and is also the most feared due to its well-deserved reputation for being refractory to antibiotic therapy. M. abscessus subsp abscessus has multiple innate antibiotic resistance mechanisms, but the most important one described so far is an inducible erythromycin methylase (erm) gene. M. abscessus subsp abscessus isolates may appear macrolide susceptible on initial in vitro testing but become macrolide resistant after exposure to macrolide. It is ...
Source: F1000 Medicine Reports - January 14, 2015 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research

Recent advances in the management of acute bronchiolitis.
Authors: Ravaglia C, Poletti V Abstract Acute bronchiolitis is characterized by acute wheezing in infants or children and is associated with signs or symptoms of respiratory infection; it is rarely symptomatic in adults and the most common etiologic agent is respiratory syncytial virus (RSV). Usually it does not require investigation, treatment is merely supportive and a conservative approach seems adequate in the majority of children, especially for the youngest ones (<3 months); however, clinical scoring systems have been proposed and admission in hospital should be arranged in case of severe disease or a very...
Source: F1000 Medicine Reports - January 14, 2015 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research

The Resistible Rise of B-Line Lung Ultrasound Artefacts
Respiration (Source: Respiration)
Source: Respiration - January 14, 2015 Category: Respiratory Medicine Source Type: research

Assessment of Competence in Simulated Flexible Bronchoscopy Using Motion Analysis
Conclusion: The motion analysis system could discriminate between different levels of experience. Automatic feedback on correct movements during self-directed training on simulators might help new bronchoscopists learn how to handle the bronchoscope like an expert.Respiration (Source: Respiration)
Source: Respiration - January 14, 2015 Category: Respiratory Medicine Source Type: research

Principles of Rehabilitation and Reactivation
Skeletal muscle dysfunction and physical inactivity are two clinically important features of a wide range of acute and chronic respiratory conditions. Optimisation of both of these features is important in order to improve physical function, prevent clinical deterioration and maximise community participation. One of the most potent and evidence-based interventions to address these physical deficits is pulmonary rehabilitation (PR). Whilst the majority of PR research has been conducted in patients with chronic obstructive pulmonary disease, there is widespread recognition that PR can benefit many other respiratory patient g...
Source: Respiration - January 14, 2015 Category: Respiratory Medicine Source Type: research

zThe Neuroprotective Role of Metformin in Advanced Glycation End Products Treated Human Neural Stem Cells is AMPK-Dependent
This study further suggests AMPK may be a potential therapeutic target for treating diabetic neurodegeneration. (Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease)
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - January 14, 2015 Category: Molecular Biology Source Type: research

Voluntary Surveillance Program for Equine Influenza Virus in the United States from 2010 to 2013
Conclusions and Clinical ImportanceThis study provides valuable and contemporary information on the frequency of EIV detected by qPCR in the United States. The results also underscore that older and previously vaccinated horses were susceptible to EIV. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - January 14, 2015 Category: Veterinary Research Authors: N. Pusterla, P.H. Kass, S. Mapes, C. Wademan, N. Akana, C. Barnett, C. MacKenzie, W. Vaala Tags: Original Article Source Type: research

Antimicrobial resistance and population structure of Staphylococcus epidermidis recovered from pig farms in Belgium
Publication date: Available online 13 January 2015 Source:The Veterinary Journal Author(s): M. Angeles Argudín , Wannes Vanderhaeghen , Patrick Butaye Pigs are known to harbour a variety of staphylococcal bacteria, including Staphylococcus epidermidis, in the upper respiratory tract. The aim of the present study was to determine the prevalence, genetic diversity, virulence and antimicrobial resistance of S. epidermidis in healthy pigs, as well as to identify the potential role of pigs as a reservoir of zoonotic infection. The overall prevalence of S. epidermidis carriage was 28%, with approximately half of the pigs test...
Source: The Veterinary Journal - January 14, 2015 Category: Veterinary Research Source Type: research

Clinical and laboratory findings of 21 patients with radiation-induced myopathy
Conclusions RIM is a potential long-term neuromuscular adverse effect of radiation exposure in Hodgkin's disease and other types of cancer manifesting predominantly as head drop and can be fatal due to neuromuscular respiratory failure. Improved radiotherapy protocols might reduce the risk of RIM and other radiation-induced neuromuscular complications. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Ghosh, P. S., Milone, M. Tags: Immunology (including allergy), Muscle disease, Neuromuscular disease, Pain (neurology), Radiology, Musculoskeletal syndromes, Surgical diagnostic tests Source Type: research

WGA-Alexa transsynaptic labeling in the phrenic motor system of adult rats: Intrapleural injection versus intradiaphragmatic injection
Conclusions Intrapleural injection of WGA-Alexa fluor conjugates is an effective method to transsynaptically label the phrenic motor system providing an alternative for the invasive laparotomy required for intradiaphragmatic injections. Furthermore, the study provides the first anatomical evidence of a direct synaptic relationship between rVRG and select NA cells. (Source: Journal of Neuroscience Methods)
Source: Journal of Neuroscience Methods - January 14, 2015 Category: Neuroscience Source Type: research

Pharmacological treatment of bacterial infections of the respiratory tract
Publication date: Available online 14 January 2015 Source:Anaesthesia &amp; Intensive Care Medicine Author(s): Bethan L. Barker , Chris Brightling Bacterial infection of the respiratory tract is amongst the commonest presentations to primary and secondary care. In addition to supportive care the mainstay of pharmacotherapy is antibiotics. Antibiotic treatment of bacterial infections of the respiratory tract needs to consider patient factors such as age, co-morbidities, location, previous antibiotic use, microbiological results and allergy. The emergence of multi-drug-resistant bacteria, partly a consequence of inappr...
Source: Anaesthesia and intensive care medicine - January 14, 2015 Category: Anesthesiology Source Type: research

The Intelence aNd pRezista Once A Day Study (INROADS): a multicentre, single‐arm, open‐label study of etravirine and darunavir/ritonavir as dual therapy in HIV‐1‐infected early treatment‐experienced subjects
ConclusionsEtravirine 400 mg and darunavir/ritonavir 800/100 mg as a two‐drug once‐daily regimen in treatment‐experienced subjects or treatment‐naïve subjects with transmitted resistance was virologically efficacious and well tolerated. (Source: HIV Medicine)
Source: HIV Medicine - January 14, 2015 Category: Infectious Diseases Authors: PJ Ruane, C Brinson, M Ramgopal, R Ryan, B Coate, M Cho, TN Kakuda, D Anderson Tags: Original Research Source Type: research

bis-Molybdopterin Guanine Dinucleotide Is Required for Persistence of Mycobacterium tuberculosis in Guinea Pigs [Bacterial Infections]
In this study, the functionality of the mobA homolog in M. tuberculosis was confirmed by demonstrating the loss of assimilatory and respiratory nitrate reductase activity in a mobA deletion mutant. This mutant displayed no survival defects in human monocytes or mouse lungs but failed to persist in the lungs of guinea pigs. These results implicate one or more bis-MGD-dependent enzymes in the persistence of M. tuberculosis in guinea pig lungs and underscore the applicability of this animal model for assessing the role of molybdoenzymes in this pathogen. (Source: Infection and Immunity)
Source: Infection and Immunity - January 14, 2015 Category: Infectious Diseases Authors: Williams, M. J., Shanley, C. A., Zilavy, A., Peixoto, B., Manca, C., Kaplan, G., Orme, I. M., Mizrahi, V., Kana, B. D. Tags: Bacterial Infections Source Type: research

The Environment of "Mycobacterium avium subsp. hominissuis" Microaggregates Induces Synthesis of Small Proteins Associated with Efficient Infection of Respiratory Epithelial Cells [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]
This study characterizes a pathogenic mechanism utilized by M. avium subsp. hominissuis to bind and invade the host respiratory epithelium, suggesting new potential targets for the development of antivirulence therapy. (Source: Infection and Immunity)
Source: Infection and Immunity - January 14, 2015 Category: Infectious Diseases Authors: Babrak, L., Danelishvili, L., Rose, S. J., Kornberg, T., Bermudez, L. E. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research

Impact of the glpQ2 Gene on Virulence in a Streptococcus pneumoniae Serotype 19A Sequence Type 320 Strain [Molecular Pathogenesis]
Glycerophosphodiester phosphodiesterase (GlpQ) metabolizes glycerophosphorylcholine from the lung epithelium to produce free choline, which is transformed into phosphorylcholine and presented on the surfaces of many respiratory pathogens. Two orthologs of glpQ genes are found in Streptococcus pneumoniae: glpQ, with a membrane motif, is widespread in pneumococci, whereas glpQ2, which shares high similarity with glpQ in Haemophilus influenzae and Mycoplasma pneumoniae, is present only in S. pneumoniae serotype 3, 6B, 19A, and 19F strains. Recently, serotype 19A has emerged as an epidemiological etiology associated with invas...
Source: Infection and Immunity - January 14, 2015 Category: Infectious Diseases Authors: Chuang, Y.-P., Peng, Z.-R., Tseng, S.-F., Lin, Y.-C., Sytwu, H.-K., Hsieh, Y.-C. Tags: Molecular Pathogenesis Source Type: research

Anthocyanins as substrates for mitochondrial complex I: protective effect against heart ischemic injury
This study provides new information on a possible application of certain anthocyanins in the regulation of energy metabolism in mammalian cells. This article is protected by copyright. All rights reserved. (Source: FEBS Journal)
Source: FEBS Journal - January 14, 2015 Category: Research Authors: Kristina Skemiene, Julius Liobikas, Vilmante Borutaite Tags: Original Article Source Type: research

Highlights from this issue
Lung cancer outcomes and the inverse care/need a car law. Cancer and pleural disease are our first 2015 themed issue. Four excellent lung cancer papers and a linked editorial by Mick Peake (see page 108) highlight marked inequalities in access to lung cancer care as a result of socioeconomic and geographic factors. Forrest et al (see page 138; Editors' choice) suggest that this is due to less access to treatment, although O'Dowd et al (see page 161) propose that delayed diagnosis remains a potentially important cause of early death. Mick Peake reminds us that the inverse care law is alive and kicking in housing estates nea...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Airwaves Source Type: research

Growing old(er) with postinfectious bronchiolitis obliterans
Most healthy children shrug off viral respiratory tract infections with little difficulty or assistance and a full recovery is the norm. A small minority, in contrast, are left with serious consequences. Important among these is postinfectious bronchiolitis obliterans (pBO) characterised by persistent—and sometimes severe—airway obstruction with functional and radiological evidence of small airway involvement that is generally unresponsive to bronchodilator or steroid treatment. Diagnosis is usually confirmed by high resolution computed tomography scanning although the images can be confused with asthma1 and cl...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Cullinan, P., Bush, A. Tags: Editorial Source Type: research

Asthma biomarkers: what constitutes a 'gold standard'?
Many studies have assessed sputum eosinophil percentage as a phenotypic descriptor in asthma patients. Adjusting inhaled corticosteroid (ICS) dose based on sputum eosinophilia can lead to better clinical outcomes than using empirical clinical guidelines alone.1 2 While techniques for collecting and analysing sputum eosinophils are available in specialty clinics, sputum analysis remains time consuming, onerous to the patient, labour intensive and is not always successful, which precludes its broader clinical generalisability to primary care settings where most asthma patients are managed. Thus, there is a need for less inva...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Arron, J. R., Izuhara, K. Tags: Editorial Source Type: research

Deprivation, distance and death in lung cancer
There are wide differences in survival rates for lung cancer both within the UK1 and when comparing the UK with many countries in the western world.2 Socio-economic inequalities have been shown to have a significant impact on survival for the large majority of cancers in adults in the UK,3 and many studies have reported lower lung cancer survival rates in patients of lower socio-economic status.4––7 There is also wide variation in treatment rates of patients with lung cancer by geographical region,1 8 9 and the paper by Forrest et al10 in this issue adds to the broadly consistent finding of lower treatment rate...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Peake, M. D. Tags: Press releases Editorial Source Type: research

PRO: confronting resistance to rule-based medicine is essential to improving outcomes
This article considers why clinicians deviate from effective rules, highlighting key issues such as the persisting culture of heroism, institutional inertia, deference to authority and personal heuristics. We argue that better rules can be created, and that clinical improvements will follow if there is a ‘common knowledge’ of these rules. Furthermore, we argue that there is a ceiling to the effectiveness of any rule, even one as simple as ensuring hand hygiene, unless individuals are held accountable for transgressions. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Blakey, J. D., Brown, M., Pinchin, J., Barley, M., Sharples, S. Tags: Editorial Source Type: research

CON: encouraging resistance to rule-based medicine is essential to improving outcomes
Know the rules well, so you can break them effectively.– Dalai Lama XIV The golden rule is that there are no golden rules.– George Bernard Shaw Of course my rules are necessary, proportionate and flexible, it is your rules that are the problem, being arbitrary in nature, excessive in force and of course far too numerous, all of which lead to unintended consequences. Rules like so much else in medicine are a quantitative science and until the far off day of every fact being known allows reliable rules to be formulated, then like an elevator in a skyscraper, the trick is knowing on which floor to get off when the...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Rosenthal, M. Tags: Editorial Source Type: research

External validation of blood eosinophils, FENO and serum periostin as surrogates for sputum eosinophils in asthma
Conclusions In patients with mild to moderate asthma, as well as patients with more severe asthma, blood eosinophils had the highest accuracy in the identification of sputum eosinophilia in asthma. The use of blood eosinophils can facilitate individualised treatment and management of asthma. Trial registration NTR1846 and NTR2364. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Wagener, A. H., de Nijs, S. B., Lutter, R., Sousa, A. R., Weersink, E. J. M., Bel, E. H., Sterk, P. J., Smids, Dekker, van de Pol, Dijkhuis, Bates, Holweg Tags: Inflammation, Asthma Biomarkers of disease Source Type: research

Mortality trends in women and men with COPD in Ontario, Canada, 1996-2012
Conclusions and relevance Mortality in people with COPD has decreased; however, the decrease has been greater in men than in women. Public health interventions and medical care appear to be improving mortality in individuals with COPD but more research is needed to determine if they are benefiting both sexes equally. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Gershon, A., Hwee, J., Victor, J. C., Wilton, A., Wu, R., Day, A., To, T. Tags: Lung neoplasms, Epidemiologic studies, Lung cancer (oncology), Lung cancer (respiratory medicine) Chronic obstructive pulmonary disease Source Type: research

Thoracentesis outcomes: a 12-year experience
Conclusions Our series of thoracenteses had a very low complication rate. Current clinical guidelines and practice patterns may not reflect evidence-based best practices. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Ault, M. J., Rosen, B. T., Scher, J., Feinglass, J., Barsuk, J. H. Tags: Pulmonary oedema, Epidemiologic studies Critical care Source Type: research

The effect of oxidative stress polymorphisms on the association between long-term black carbon exposure and lung function among elderly men
We report stronger associations between long-term BC exposure and increased rate of lung function decline, but not baseline lung function level, among participants with higher oxidative stress allelic risk profiles compared with participants with lower risk profiles. Associations were strongest when evaluating 5-year moving averages of BC exposure. A 0.5 µg/m3 increase in 5-year BC exposure was associated with a 0.1% yearly increase in FVC (95% CI –0.5 to 0.7) among participants with low genetic risk scores and a 1.3% yearly decrease (95% CI –1.8 to –0.8) among those with high scores (p-interac...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Mordukhovich, I., Lepeule, J., Coull, B. A., Sparrow, D., Vokonas, P., Schwartz, J. Tags: Environmental exposure Source Type: research

The role of receipt and timeliness of treatment in socioeconomic inequalities in lung cancer survival: population-based, data-linkage study
Conclusions Socioeconomic inequalities in survival from lung cancer were statistically explained by socioeconomic inequalities in receipt of treatment, but not by timeliness of referral and treatment. Further research is required to determine the currently unexplained socioeconomic variance in treatment rates. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Forrest, L. F., Adams, J., Rubin, G., White, M. Tags: Lung neoplasms, Editor's choice, Lung cancer (oncology), Lung cancer (respiratory medicine) Source Type: research

The impact of the 'hub and spoke' model of care for lung cancer and equitable access to surgery
Conclusions Surgical centres that serve the largest catchment populations have high resection rates for patients first seen in their own centre but, in contrast, low resection rates for patients first seen at the surrounding centres they serve. Our findings demonstrate the importance of going further than relating resection rates to hospital volume or surgeon number, and show that there is a pressing need to design lung cancer services which enable all patients, including those first seen at non-surgical centres, to have equal access to lung cancer surgery. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Khakwani, A., Rich, A. L., Powell, H. A., Tata, L. J., Stanley, R. A., Baldwin, D. R., Duffy, J. P., Hubbard, R. B. Tags: Lung neoplasms, Epidemiologic studies, Lung cancer (oncology), Lung cancer (respiratory medicine) Source Type: research

Survival of Australian lung cancer patients and the impact of distance from and attendance at a thoracic specialist centre: a data linkage study
Conclusions NSCLC outcome is best when patients are treated in a specialist hospital. Greater distance to the NASH can affect its outcome by reducing the likelihood of being treated in a specialist hospital. Research is needed into patient and health service barriers to referral of NSCLC patients for specialist care. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Tracey, E., McCaughan, B., Badgery-Parker, T., Young, J., Armstrong, B. Tags: Lung neoplasms, Lung cancer (oncology), Lung cancer (respiratory medicine) Source Type: research

What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?
Conclusions Patients who die early from lung cancer are interacting with primary care prediagnosis, suggesting potentially missed opportunities to identify them earlier. A general increase in CXR requests may not improve survival; rather, a more timely and appropriate targeting of this investigation using risk assessment tools needs further assessment. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: O'Dowd, E. L., McKeever, T. M., Baldwin, D. R., Anwar, S., Powell, H. A., Gibson, J. E., Iyen-Omofoman, B., Hubbard, R. B. Tags: Lung neoplasms, Epidemiologic studies, Open access, General practice / family medicine, Press releases, Lung cancer (oncology), Screening (oncology), Lung cancer (respiratory medicine), Radiology (diagnostics), Health education, Smoking, Health effects of Source Type: research

Pulmonary function of a paediatric cohort of patients with postinfectious bronchiolitis obliterans. A long term follow-up
Conclusions After a 12 year follow-up period, pulmonary function remained severely impaired, showing an obstructive pattern with air trapping that slowly improved during childhood. An unequal growth of lung parenchyma over the airways suggests dysinaptic growth. Patients required frequent readmission due to recurrent respiratory infections, and hypoxaemia improved slowly over time. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Colom, A. J., Maffey, A., Bournissen, F. G., Teper, A. Tags: Bronchiolitis, TB and other respiratory infections, Airway biology, Bronchitis, Interstitial lung disease, Lung function, Mechanical ventilation Paediatric lung disease Source Type: research

Linear endobronchial ultrasonography: a novelty turned necessity for mediastinal nodal assessment
Linear endobronchial ultrasound was first described in 2003. Since then the technique has spread rapidly and has now become an established practice in many centres as the first-line mediastinal investigation for the diagnosis and staging of lung cancer. In combination with endoscopic ultrasound, the majority of the mediastinum can be assessed and this approach has been shown to have equivalent accuracy to surgical staging. This strategy is also cost-effective. New tissue processing techniques using liquid-based thin-layer cytology and cell blocks have increased diagnostic yield using immunohistochemical staining and molecu...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Rintoul, R. C., Ahmed, R., Dougherty, B., Carroll, N. R. Tags: Lung neoplasms, Clinical trials (epidemiology), Lung cancer (oncology), Lung cancer (respiratory medicine), Radiology (diagnostics) Review Source Type: research

Correction
AS Delussu, A Laudisio, C Pedone, et al. S124 Effects of two adapted physical activity training programmes on pulmonary functionality and exercise capacity in patients affected by chronic obstructive pulmonary disease. Thorax 2014;69(Suppl 2):A66. doi:10.1136/thoraxjnl-2014-206260.130 The following funding statement should have been included with the abstract: Research was granted by the Italian Health Ministry, Project code GR-2009-1596137. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research

Correction
P20 - withdrawn DA Dorward, CD Lucas, MK Doherty, et al. P20 Delineating the contribution of formylated peptides and formyl peptide reception 1 to the pathogenesis of acute lung injury. Thorax 2014;69(Suppl 2):A86. doi: 10.1136/thoraxjnl-2014-206260.169 (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research

Correction
P172 - withdrawn G Bettini, MA Mazzei, D Castria, et al. P172 Pulmonary hypertension in IPF: utility of HRCT. Thorax 2014;69(Suppl 2):A150. doi: 10.1136/thoraxjnl-2014-206260.300 (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research

Correction
P198 - withdrawn JE Foweraker, S Jalili, V Athithan, et al. P198 New approaches to the culture of Mycobactrium abscessus complex from patients with cystic fibrosis. Thorax 2014;69(Suppl 2):A163. doi: 10.1136/thoraxjnl-2014-206260.327 (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research

Markers of inflammation: data from the MOSAIC randomised trial of CPAP for minimally symptomatic OSA
The Multi-centre Obstructive Sleep Apnoea Interventional Cardiovascular (MOSAIC) trial compared 6 months of CPAP therapy, versus no CPAP, in 391 patients with minimally symptomatic obstructive sleep apnoea (OSA). We now report some exploratory outcomes, markers of systemic inflammation (interleukin 6 (IL-6), IL-10, C reactive protein, tumour necrosis factor). We found no consistent changes (all p values >0.13). Trial registration number: ISRCTN 34164388. (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Authors: Stradling, J. R., Craig, S. E., Kohler, M., Nicoll, D., Ayers, L., Nunn, A. J., Bratton, D. J. Tags: Inflammation Research letter Source Type: research

Correction
S Cormack. P86 Do we need a specific guideline for the management of Aspiration Pneumonia (AP)? Thorax 2014;69(Suppl 2):A113. doi:10.1136/thoraxjnl-2014-206260.226 The author names should read: S Cormack, G Antunes. James Cook University Hospital, Middlesbrough, United Kingdom (Source: Thorax)
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research

Correction
NW Williams, KO Ostridge, VK Kim, et al. P153 Stratifying pneumonic episodes and acute exacerbations in COPD patients—a continuum or discrete phenomena? Thorax 2014;69(Suppl 2):A141. doi: 10.1136/thoraxjnl-2014-206260.281 The author names should read: Williams N,1 Ostridge K,1 Kim V,1 Barton A,1 Wojtas MM,2 Harden S,3 Aris E,4 Peeters M,4 Devaster JM,4 Bourne S,5 Wilkinson T6 1Southampton NIHR Respiratory Biomedical Research Unit, University Hospital Southampton Foundation NHS Trust, Southampton, England 2NIHR Southampton Biomedical Research Centre, Southampton, England 3Department of Radiology, University Hospitals ...
Source: Thorax - January 14, 2015 Category: Respiratory Medicine Tags: Corrections Source Type: research