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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Innate Immunity and the Inter-exposure Interval Determine the Dynamics of Secondary Influenza Virus Infection and Explain Observed Viral Hierarchies
by Pengxing Cao, Ada W. C. Yan, Jane M. Heffernan, Stephen Petrie, Robert G. Moss, Louise A. Carolan, Teagan A. Guarnaccia, Anne Kelso, Ian G. Barr, Jodie McVernon, Karen L. Laurie, James M. McCaw Influenza is an infectious disease that primarily attacks the respiratory system. Innate immunity provides both a very early defense to influenza virus invasion and an effective control of viral growth. Previous modelling studies of virus–innate immune response interactions have focused on infection with a single virus and, while improving our understanding of viral and immune dynamics, have been unable to effectively evaluate...
Source: PLoS Computational Biology - August 18, 2015 Category: Biology Authors: Pengxing Cao et al. Source Type: research

Pulse oximetry as a screening tool for detecting major congenital heart defects in Indian newborns
Conclusions Pulse oximetry is a sensitive screening tool for detecting major CHDs in Indian newborns. It adds significant value to the current practice of using clinical examination as a sole screening tool for detecting major CHDs. However, specificity of pulse oximetry was much lower in our study. Possible reasons for low specificity could be non-repetition of pulse oximetry in newborns with initial lower saturations, high prevalence of infections and respiratory issues in our cohort and use of non-motion tolerant oximeter. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2015 Category: Perinatology & Neonatology Authors: Saxena, A., Mehta, A., Ramakrishnan, S., Sharma, M., Salhan, S., Kalaivani, M., Juneja, R. Tags: Congenital heart disease, Echocardiography, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Screening (epidemiology), Screening (public health) Original articles Source Type: research

International survey on periextubation practices in extremely preterm infants
Conclusions Periextubation practices vary considerably; decisions are frequently physician dependent and not evidence based. The definition of EF is variable and well-defined criteria for reintubation are rarely used. High-quality trials are required to inform guidelines and standardise periextubation practices. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2015 Category: Perinatology & Neonatology Authors: Al-Mandari, H., Shalish, W., Dempsey, E., Keszler, M., Davis, P. G., Sant'Anna, G. Tags: Epidemiologic studies, Childhood nutrition, Child health, Infant health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care, Mechanical ventilation Original articles Source Type: research

Comparison of Established Diagnostic Methodologies and a Novel Bacterial smpB Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Isolates Associated with Respiratory Tract Infections [Bacteriology]
In this study, a novel real-time PCR diagnostic assay targeting the smpB gene was designed to detect all serogroups of H. influenzae. The assay was validated using a panel of well-characterized Haemophilus spp. Subsequently, 44 Haemophilus clinical isolates were collected, and 36 isolates were identified as H. influenzae using a gold standard methodology that combined the results of matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) and a fucK diagnostic assay. Using the novel smpB diagnostic assay, 100% concordance was observed with the gold standard, demonstrating a sensitiv...
Source: Journal of Clinical Microbiology - August 18, 2015 Category: Microbiology Authors: Reddington, K., Schwenk, S., Tuite, N., Platt, G., Davar, D., Coughlan, H., Personne, Y., Gant, V., Enne, V. I., Zumla, A., Barry, T. Tags: Bacteriology Source Type: research

Cohort Study of Airway Mycobiome in Adult Cystic Fibrosis Patients: Differences in Community Structure between Fungi and Bacteria Reveal Predominance of Transient Fungal Elements [Mycology]
This study compared the bacterial and fungal communities of sputum samples from a large cohort of 56 adult patients with cystic fibrosis (CF) during nonexacerbation periods and under continuous antibiotic treatment. Molecular fingerprinting based on single-strand conformation polymorphism (SSCP) analysis revealed fundamental differences between bacterial and fungal communities. Both groups of microorganisms were taxonomically classified by identification of gene sequences (16S rRNA and internal transcript spacer), and prevalences of single taxa were determined for the entire cohort. Major bacterial pathogens were frequentl...
Source: Journal of Clinical Microbiology - August 18, 2015 Category: Microbiology Authors: Kramer, R., Sauer-Heilborn, A., Welte, T., Guzman, C. A., Abraham, W.-R., Hofle, M. G. Tags: Mycology Source Type: research

Infectious Middle East Respiratory Syndrome Coronavirus Excretion and Serotype Variability Based on Live Virus Isolates from Patients in Saudi Arabia [Virology]
The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) has infected at least 1,082 people, including 439 fatalities. So far, no empirical virus isolation study has been done to elucidate infectious virus secretion or serotype variability. Here, we used 51 respiratory samples from 32 patients with confirmed MERS-CoV infection for virus isolation in Vero B4 and Caco-2 cells. We found Caco-2 cells to significantly enhance isolation success over routinely used Vero cells. Isolation success correlated with viral RNA concentration and time after diagnosis as well as with the amount of IgA antibodies secreted i...
Source: Journal of Clinical Microbiology - August 18, 2015 Category: Microbiology Authors: Muth, D., Corman, V. M., Meyer, B., Assiri, A., Al-Masri, M., Farah, M., Steinhagen, K., Lattwein, E., Al-Tawfiq, J. A., Albarrak, A., Muller, M. A., Drosten, C., Memish, Z. A. Tags: Virology Source Type: research

Isothermal Detection of Mycoplasma pneumoniae Directly from Respiratory Clinical Specimens [Bacteriology]
Mycoplasma pneumoniae is a leading cause of community-acquired pneumonia (CAP) across patient populations of all ages. We have developed a loop-mediated isothermal amplification (LAMP) assay that enables rapid, low-cost detection of M. pneumoniae from nucleic acid extracts and directly from various respiratory specimen types. The assay implements calcein to facilitate simple visual readout of positive results in approximately 1 h, making it ideal for use in primary care facilities and resource-poor settings. The analytical sensitivity of the assay was determined to be 100 fg by testing serial dilutions of target DNA rangin...
Source: Journal of Clinical Microbiology - August 18, 2015 Category: Microbiology Authors: Petrone, B. L., Wolff, B. J., DeLaney, A. A., Diaz, M. H., Winchell, J. M. Tags: Bacteriology Source Type: research

Cladosporium Species Recovered from Clinical Samples in the United States [Mycology]
Cladosporium species are ubiquitous, saprobic, dematiaceous fungi, only infrequently associated with human and animal opportunistic infections. We have studied a large set of Cladosporium isolates recovered from clinical samples in the United States to ascertain the predominant species there in light of recent taxonomic changes in this genus and to determine whether some could possibly be rare potential pathogens. A total of 92 isolates were identified using phenotypic and molecular methods, which included sequence analysis of the internal transcribed spacer (ITS) region and a fragment of the large subunit (LSU) of the nuc...
Source: Journal of Clinical Microbiology - August 18, 2015 Category: Microbiology Authors: Sandoval-Denis, M., Sutton, D. A., Martin-Vicente, A., Cano-Lira, J. F., Wiederhold, N., Guarro, J., Gene, J. Tags: Mycology Source Type: research

Contribution of CCK receptors to cardiovascular and respiratory effects of cholecystokinin in anesthetized rats
The study investigated the share of vagal input at infra- and supra-nodosal level and the contribution of CCK1 and CCK2 receptors to the cardiorespiratory responses produced by an intravenous injection of sulfated cholecystokinin octapeptide (CCK-8) in anesthetized rats.This compound administered intravenously at a dose of 50 μg/kg induced short-lived decline in tidal volume and respiratory rate resulting in depression of minute ventilation. Midcervical vagotomy had no effect on CCK-8-evoked ventilatory changes, whereas supranodosal denervation abolished slowing down of breathing. (Source: Neuropeptides)
Source: Neuropeptides - August 18, 2015 Category: Neuroscience Authors: Katarzyna Kaczyńska, Małgorzata Szereda-Przestaszewska Source Type: research

Pharmacists' Knowledge and Attitudes towards Upper Respiratory Infections (URI) in Iran: A Cross Sectional Study.
Conclusion According to a high response rate for the question about efficiency of antibiotics prescription guidelines, reliable information on the appropriate use of antibiotics should be more widely available for pharmacists. PMID: 26282898 [PubMed - as supplied by publisher] (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - August 18, 2015 Category: Cancer & Oncology Authors: Eslami N, Eshraghi A, Vaseghi G, Mehdizadeh M, Masjedi M, Mehrpooya M Tags: Rev Recent Clin Trials Source Type: research

EGFR mutant allelic-specific imbalance assessment in routine samples of non-small cell lung cancer
In conclusion, EGFR-MASI is a significant event in NSCLC, specifically associated with EGFR exon 19 deletions. However, EGFR-MASI does not seem to play a role in predicting the response to first-generation EGFR small molecules inhibitors. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - August 18, 2015 Category: Pathology Authors: Malapelle, U., Vatrano, S., Russo, S., Bellevicine, C., de Luca, C., Sgariglia, R., Rocco, D., de Pietro, L., Riccardi, F., Gobbini, E., Righi, L., Troncone, G. Tags: Molecular genetics, Lung cancer (oncology), Lung cancer (respiratory medicine) Short report Source Type: research

Cystic fibrosis gene therapy: the first trial
In August, Archivist reported on a successful trial of new molecules that enhance function of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein at an intracellular level (ADC doi:10.1136/archdischild-2015-309089). Hot on its heels comes a report of the first Phase 2b trial of another completely novel treatment: gene therapy, which involves transferring correct copies of CFTR DNA into lung epithelial cells, by administering it in a complex with cationic liposomes in nebulised form (Alton E et al. Lancet Respiratory Medicine 2015 doi.org/10.1016/S2213-2600(15)00245-3). The trial recruited 140 CF patient...
Source: Archives of Disease in Childhood - August 18, 2015 Category: Pediatrics Tags: Miscellanea Source Type: research

Severe combined immunodeficiency syndrome presenting with disseminated BCG infection
A 4-month-old boy presented with fever, lethargy and irritability on a background of faltering growth. He was pale, febrile, in respiratory distress. He had red papular skin lesions on torso and a large discharging ulcer at BCG inoculation site (administered shortly after birth) (figure 1). He was anaemic (haemoglobin 4.8 g/dL) and lymphopenic (1.16x109/L) with an elevated C-reactive protein (360 mg/L). Numerous hyperlucent lesions were found on skeletal survey, and ultrasound demonstrated hypoechoic lesions in liver and spleen (figure 2). Lymphocyte phenotyping revealed severe T- and NK-cell lymphopenia (15 T-cells/&...
Source: Archives of Disease in Childhood - August 18, 2015 Category: Pediatrics Authors: Fitzpatrick, P., Leonard, J., Twomey, E., Malone, A., Nademi, Z., Jackson, M., Abinun, M., Leahy, T. R., Gavin, P. J. Tags: Miscellanea Source Type: research

Question 1: Does vitamin D supplementation prevent acute lower respiratory tract infections in children?
Scenario A 5-year-old boy presents with a 4-day history of cough, fever and increased work of breathing. On auscultation, he has right-sided basal crepitations. A chest X-ray shows a right lower lobe pneumonia. He has a medical history of vitamin D deficiency; however, his mother informs you that his vitamin D levels are now normal. This is his second episode of pneumonia since birth. You wonder if there is any evidence to suggest that vitamin D supplementation will reduce his risk of further episodes of lower respiratory tract infection (LRTI). Structured clinical question In a child with pneumonia (patient), does vitamin...
Source: Archives of Disease in Childhood - August 18, 2015 Category: Pediatrics Authors: Ali, S. R., McDevitt, H. Tags: ADC Archimedes, Epidemiologic studies, Immunology (including allergy), Pneumonia (infectious disease), TB and other respiratory infections, Malnutrition, Radiology, Airway biology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (di Source Type: research

Response to the Letter Entitled “Comments Concerning Comparison of Airway and Systemic Malondialdehyde Levels for Assessment of Oxidative Stress in Cystic Fibrosis”
(Source: Lung)
Source: Lung - August 18, 2015 Category: Respiratory Medicine Source Type: research

Objective Measurement of Cough Frequency During COPD Exacerbation Convalescence
This study of objective cough monitoring using the Hull Automated Cough Counter and Leicester Cough Monitor software confirms that this system has the ability to detect a significant decrease in cough frequency during AE-COPD convalescence. The ability to detect clinically meaningful change indicates a potential role in home monitoring of COPD patients. (Source: Lung)
Source: Lung - August 18, 2015 Category: Respiratory Medicine Source Type: research

Glycolytic Reprogramming Mediates Myofibroblast Differentiation and Promotes Lung Fibrosis.
CONCLUSIONS: Our data support the novel concept of glycolytic reprogramming in the pathogenesis of lung fibrosis and provide proof-of-concept that targeting this pathway may be efficacious in treating fibrotic disorders, such as IPF. PMID: 26284610 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 18, 2015 Category: Respiratory Medicine Authors: Xie N, Tan Z, Banerjee S, Cui H, Ge J, Liu RM, Bernard K, Thannickal VJ, Liu G Tags: Am J Respir Crit Care Med Source Type: research

Foreign Body Aspiration of a Press-through Package that Lodged Between the Vocal Cords.
PMID: 26284505 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 18, 2015 Category: Respiratory Medicine Authors: Lee HY, Choi SM Tags: Am J Respir Crit Care Med Source Type: research

Relapse Rate and Factors Related to Relapse in a 1-Year Follow-Up of Subjects Participating in a Smoking Cessation Program.
CONCLUSION: The relapse rate in a 1-y period was 51.4%. Similar to previous studies, alcohol intake presented a relapse risk. In subjects receiving drug treatment, planning support meetings more frequently and paying attention to adverse effects may increase the success of smoking cessation. PMID: 26286738 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Koçak ND, Eren A, Boğa S, Aktürk ÜA, Öztürk ÜA, Arinç S, Şengül A Tags: Respir Care Source Type: research

Predictive Model of Hospital Admission for COPD Exacerbation.
CONCLUSIONS: This model can identify patients at high risk of hospital admission for COPD exacerbation in our setting. Further studies are needed to validate the model in different populations and settings. PMID: 26286737 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Montserrat-Capdevila J, Godoy P, Marsal JR, Barbé F Tags: Respir Care Source Type: research

Albuterol Delivery via Facial and Tracheostomy Route in a Model of a Spontaneously Breathing Child.
CONCLUSIONS: The effect of changing the delivery route from face to tracheostomy was variable and depended on the delivery device and the breathing pattern. There is no advantage of using the assisted technique to enhance aerosol delivery. PMID: 26286736 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Cooper B, Berlinski A Tags: Respir Care Source Type: research

Electromyographic Manifestations of Fatigue Correlate With Pulmonary Function, 6-Minute Walk Test, and Time to Exhaustion in COPD.
CONCLUSIONS: The electromyographic manifestations of fatigue during sustained quadriceps contraction significantly correlated with disease severity and exercise tolerance in moderate to severe COPD. PMID: 26286735 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Boccia G, Dardanello D, Rinaldo N, Coratella G, Schena F, Rainoldi A Tags: Respir Care Source Type: research

Accuracy of the Electronic Health Record: Patient Height.
CONCLUSIONS: For populations, mean height calculated from values charted in the EHR is similar to that estimated from ulnar length. However, for individuals, differences in height between the 2 sources can be large, leading to large differences in predicted BW and resultant VT set in terms of mL/kg. PMID: 26286734 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Jurecki MC, Chatburn RL, Sasidhar M Tags: Respir Care Source Type: research

The Plasminogen System and Transforming Growth Factor-β in Subjects With Obstructive Sleep Apnea Syndrome: Effects of CPAP Treatment.
CONCLUSIONS: Our results suggest an imbalance of fibrinolysis related to OSAS and an improvement of the prothrombotic state after the CPAP treatment. PMID: 26286733 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 18, 2015 Category: Respiratory Medicine Authors: Steffanina A, Proietti L, Antonaglia C, Palange P, Angelici E, Canipari R Tags: Respir Care Source Type: research

Sphingomonas hylomeconis sp. nov., isolated from the stem of Hylomecon japonica.
Abstract A yellow-pigmented bacterium, designated strain GZJT-2T, was isolated from the stem of Hylomecon japonica (Thunb.) Prantl et Kündig collected from Taibai Mountain in Shaanxi Province, north-west China. Cells of strain GZJT-2T were Gram-reaction-negative, strictly aerobic, rod-shaped, non-spore-forming and non-motile. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain GZJT-2T was a member of the genus Sphingomonas, with sequence similarities of 92.1-96.9 % to type strains of recognized Sphingomonas species (92.1 % to S. oligoaromativorans SY-6T and 96.9 % to S. oligophenolica JCM 120...
Source: International Journal of Systematic and Evolutionary Microbiology - August 18, 2015 Category: Microbiology Authors: Akbar A, Chen C, Zhu L, Xin K, Cheng J, Yang Q, Zhao L, Zhang L, Shen X Tags: Int J Syst Evol Microbiol Source Type: research

Chryseobacterium echinoideorum sp. nov., isolated from sea urchins (Tripneustes gratilla) in Penghu Island (Taiwan).
Abstract A Gram-stain-negative, aerobic, non-motile rods, flexirubin-producing bacterium, designated strain CC-CZW010T, was isolated from the edible sea urchin Tripneustes gratilla in Penghu Island. The isolate grew optimally at pH 7.0 and 30ºС in the presence of 2% (w/v) NaCl. The most closely related strains in terms of 16S rRNA gene sequence similarity were Chryseobacterium taihuense NBRC 108747T (97.6%) and Chryseobacterium aquaticum KCTC 12483T (96.7%). Phylogenetic analyses based on 16S rRNA genes revealed a distinct taxonomic position attained by strain CC-CZW010T with respect to other Chryseobacterium spe...
Source: International Journal of Systematic and Evolutionary Microbiology - August 18, 2015 Category: Microbiology Authors: Lin SY, Hameed A, Wen CZ, Liu YC, Shen FT, Hsu YH, Lai WA, Young CC Tags: Int J Syst Evol Microbiol Source Type: research

Directed evolution to produce sludge communities with improved oxygen uptake abilities.
Abstract Two activated sludge cultures, seeded with activated sludge from the same source, were cultivated for 370 days in synthetic wastewater. Both cultures were transferred weekly to fresh medium; one culture was operated at high dissolved oxygen (DO) (near saturation) and the other at low DO (0.25 mg O2/L). There were significant changes in the abundances of bacterial species and phyla present in each culture throughout the 370-day operational period. In the low DO culture, over time, there was a continuously increasing proportion of cells of species known to encode truncated hemoglobins (Hbs). These are the...
Source: Applied Microbiology and Biotechnology - August 18, 2015 Category: Microbiology Authors: Kunkel SA, Pagilla KR, Stark BC Tags: Appl Microbiol Biotechnol Source Type: research

Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells.
Abstract Oxidative stress and mitochondrial dysfunction are implicated in neuronal apoptosis associated with Huntington's disease. Naringin is the flavanone present in grapefruit and related citrus species possess diverse pharmacological and therapeutic properties including antioxidant, anti-apoptotic, and neuroprotective properties. The aim of this study was to investigate the protective effect of naringin on 3-nitropropionic acid (3-NP)-induced neurotoxicity in pheochromocytoma cells (PC12) cells and to explore its mechanism of action. Naringin protects PC12 cells from 3-NP neurotoxicity, as evaluated the by cel...
Source: Molecular and Cellular Biochemistry - August 18, 2015 Category: Biochemistry Authors: Kulasekaran G, Ganapasam S Tags: Mol Cell Biochem Source Type: research

Haematological rather than skeletal muscle adaptations contribute to the increase in peak oxygen uptake induced by moderate endurance training.
In conclusion, the improvement in VO2peak following 6 weeks of ET is primarily attributed to increases in Qpeak and oxygen-carrying capacity of blood in untrained healthy young subjects. This article is protected by copyright. All rights reserved. PMID: 26282186 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - August 18, 2015 Category: Physiology Authors: Montero D, Cathomen A, Jacobs RA, Flück D, de Leur J, Keiser S, Bonne T, Kirk N, Lundby AK, Lundby C Tags: J Physiol Source Type: research

Sleep stage classification with ECG and respiratory effort
Automatic sleep stage classification with cardiorespiratory signals has attracted increasing attention. In contrast to the traditional manual scoring based on polysomnography, these signals can be measured using advanced unobtrusive techniques that are currently available, promising the application for personal and continuous home sleep monitoring. This paper describes a methodology for classifying wake, rapid-eye-movement (REM) sleep, and non-REM (NREM) light and deep sleep on a 30 s epoch basis. A total of 142 features were extracted from electrocardiogram and thoracic respiratory effort measured with respiratory i...
Source: Physiological Measurement - August 18, 2015 Category: Physiology Authors: Pedro Fonseca, Xi Long, Mustafa Radha, Reinder Haakma, Ronald M Aarts and J?r?me Rolink Source Type: research

Probabilistic cardiac and respiratory based classification of sleep and apneic events in subjects with sleep apnea
Current clinical standards to assess sleep and its disorders lack either accuracy or user-friendliness. They are therefore difficult to use in cost-effective population-wide screening or long-term objective follow-up after diagnosis. In order to fill this gap, the use of cardiac and respiratory information was evaluated for discrimination between different sleep stages, and for detection of apneic breathing. Alternative probabilistic visual representations were also presented, referred to as the hypnocorrogram and apneacorrogram. Analysis was performed on the UCD sleep apnea database, available on Physionet. The pres...
Source: Physiological Measurement - August 18, 2015 Category: Physiology Authors: T Willemen, C Varon, A Caicedo Dorado, B Haex, J Vander Sloten and S Van Huffel Source Type: research

Physiologically Based Pharmacokinetic Modeling of Ethyl Acetate and Ethanol in Rodents and Humans.
Abstract A physiologically based pharmacokinetic (PBPK) model was developed and applied to a metabolic series approach for the ethyl series (i.e., ethyl acetate, ethanol, acetaldehyde, and acetate). This approach bases toxicity information on dosimetry analyses for metabolically linked compounds using pharmacokinetic data for each compound and toxicity data for parent or individual compounds. In vivo pharmacokinetic studies of ethyl acetate and ethanol were conducted in rats following IV and inhalation exposure. Regardless of route, ethyl acetate was rapidly converted to ethanol. Blood concentrations of ethyl aceta...
Source: Regulatory Toxicology and Pharmacology : RTP - August 18, 2015 Category: Toxicology Authors: Crowell SR, Smith JN, Creim JA, Faber W, Teeguarden JG Tags: Regul Toxicol Pharmacol Source Type: research

Influenza vaccination and risk of stroke: Self-controlled case-series study.
CONCLUSIONS: Influenza vaccination is associated with a reduction in incidence of stroke. This study supports previous studies which have shown a beneficial association of influenza vaccination for stroke prevention. PMID: 26296496 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - August 18, 2015 Category: Allergy & Immunology Authors: Asghar Z, Coupland C, Siriwardena N Tags: Vaccine Source Type: research

Class III Obesity is Not a Contraindication to Venovenous Extracorporeal Membrane Oxygenation Support.
CONCLUSIONS: In this review, class III obesity was not associated with poorer outcomes, and based on these data, ECMO support should not be withheld from this patient population. PMID: 26296270 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 18, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Kon ZN, Dahi S, Evans CF, Byrnes KA, Bittle GJ, Wehman B, Rector RP, McCormick BM, Herr DL, Sanchez PG, Pham SM, Griffith BP Tags: Ann Thorac Surg Source Type: research

Long-Term Venovenous Extracorporeal Membrane Oxygenation Support for Acute Respiratory Distress Syndrome.
CONCLUSIONS: Previously, long-term ECMO support was thought to be associated with unfavorable outcomes. This study, however, may provide support for the efficacy of ECMO support even for 3 weeks or more as a bridge to recovery or transplantation. PMID: 26296269 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 18, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Kon ZN, Dahi S, Evans CF, Byrnes KA, Bittle GJ, Wehman B, Rector RP, McCormick BM, Herr DL, Sanchez PG, Pham SM, Griffith BP Tags: Ann Thorac Surg Source Type: research

Age at asthma onset and asthma self-management education among adults in the United States
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 17, 2015 Category: Respiratory Medicine Tags: article Source Type: research

A case of uncontrolled severe asthma patient with coexisting carcinoid tumor presenting as pneumomediastinum
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 17, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Decisional conflict in asthma patients: a cross sectional study
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - August 17, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Bench-to-bedside review: the effects of hyperoxia during critical illness
Oxygen administration is uniformly used in emergency and intensive care medicine and has life-saving potential in critical conditions. However, excessive oxygenation also has deleterious properties in various pathophysiological processes and consequently both clinical and translational studies investigating hyperoxia during critical illness have gained increasing interest. Reactive oxygen species are notorious by-products of hyperoxia and play a pivotal role in cell signaling pathways. The effects are diverse, but when the homeostatic balance is disturbed, reactive oxygen species typically conserve a vicious cycle of tissu...
Source: Critical Care - August 17, 2015 Category: Intensive Care Authors: Hendrik HelmerhorstMarcus SchultzPeter van der VoortEvert de JongeDavid van Westerloo Source Type: research

Ultrasound assessment of congenital fetal lung masses and neonatal respiratory outcomes
ConclusionIn pregnancies diagnosed with fetal lung masses, CVR predicted normal respiratory outcomes and need for NICU admission. This information may be helpful for delivery planning. (Source: Prenatal Diagnosis)
Source: Prenatal Diagnosis - August 17, 2015 Category: Perinatology & Neonatology Authors: Maisa Feghali, Katie M. Jean, Stephen P. Emery Tags: Original Article Source Type: research

Caution: Reptile pets shuttle grasshopper allergy and asthma into homes
Abstract The numbers of reptiles in homes has at least doubled in the last decade in Europe and the USA. Reptile purchases are increasingly triggered by the attempt to avoid potentially allergenic fur pets like dogs and cats. Consequently, reptiles are today regarded as surrogate pets initiating a closer relationship with the owner than ever previously observed. Reptile pets are mostly fed with insects, especially grasshoppers and/or locusts, which are sources for aggressive airborne allergens, best known from occupational insect breeder allergies. Exposure in homes thus introduces a new form of domestic allergy ...
Source: World Allergy Organization Journal - August 17, 2015 Category: Allergy & Immunology Source Type: research

Deficiency of autophagy protein Map1-LC3b mediates IL-17-dependent lung pathology during respiratory viral infection via ER stress-associated IL-1
N W Lukacs (Source: Mucosal Immunology)
Source: Mucosal Immunology - August 17, 2015 Category: Allergy & Immunology Authors: M ReedS H MorrisA B OwczarczykN W Lukacs Source Type: research