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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

A bedside clinical and ultrasound-based approach to hemodynamic instability - Part II: bedside ultrasound in hemodynamic shock: Continuing Professional Development.
Abstract Shock is defined as a situation where oxygen transport and delivery is inadequate to meet oxygen demand. The patient in shock is evaluated through medical history, physical examination, and careful observation of the hemodynamic and respiratory monitors. The patient is initially managed with basic resuscitation measures, however bedside ultrasound should be performed if hemodynamic instability persists. We propose to use ultrasound of the inferior vena cava (IVC), and the concept of venous return, as the initial step in order to identify the mechanism of shock. Doppler examination of the hepatic venous flo...
Source: Canadian Journal of Anaesthesia - October 2, 2014 Category: Anesthesiology Authors: Vegas A, Denault A, Royse C Tags: Can J Anaesth Source Type: research

Lung-residing Myeloid-derived Suppressors Display Dual Functionality in Murine Pulmonary Tuberculosis.
Conclusion: Our data reveal that MDSCs provide a niche for pathogen survival and tailor immunity in TB. These findings suggest MDSCs as amenable targets for host-directed therapies and emphasize them as cellular-immune regulators during chronic inflammatory conditions, including chronic infections and microbial complications of neoplastic disorders. PMID: 25275852 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 2, 2014 Category: Respiratory Medicine Authors: Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A Tags: Am J Respir Crit Care Med Source Type: research

Ultra-minimally invasive cardiac surgery: robotic surgery and awake CABG.
In this study, the potential of a new awake CABG protocol using only epidural anesthesia was investigated for realizing day surgery and was found to be a promising modality for ultra-minimally invasive cardiac surgery. We herein review robot-assisted cardiac surgery and awake off-pump coronary artery bypass grafting as ultra-minimally invasive cardiac surgeries. PMID: 25274467 [PubMed - as supplied by publisher] (Source: Hand Surgery)
Source: Hand Surgery - October 2, 2014 Category: Surgery Authors: Ishikawa N, Watanabe G Tags: Surg Today Source Type: research

Impact of feedback on physical activity levels of individuals with chronic obstructive pulmonary disease during pulmonary rehabilitation: A feasibility study.
This study aimed at investigating whether providing feedback on physical activity (PA) levels to patients with chronic obstructive pulmonary disease (COPD) is feasible and enhances daily PA during pulmonary rehabilitation (PR). Patients with COPD participated in a 12-week PR program. Daily PA was measured using activity monitors on weeks 1, 7, and 12, and feedback was given in the following weeks on the number of steps, time spent in sedentary, light, and moderate-to-vigorous intensity activities, and time spent standing, sitting, and lying. Compliance with PA monitoring was collected. Two focus groups were conducted to ob...
Source: Chronic Respiratory Disease - October 2, 2014 Category: Respiratory Medicine Authors: Cruz J, Brooks D, Marques A Tags: Chron Respir Dis Source Type: research

The Clinical Course of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia.
Conclusions:DIPNECH is a female-predominant lung disease manifested by dyspnea and cough, physiological obstruction and nodules on HRCT. Additional research is needed to understand the natural history of this disease and validate the proposed diagnostic criteria. Background: Current understanding of the clinical course of Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH) is poor and based predominantly on small case series. In our clinical experience, we have found that the diagnosis of DIPNECH is frequently delayed, as respiratory symptoms are ascribed to other lung conditions. Objectives: To ...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Carr LL, Chung JH, Duarte Achcar R, Lesic Z, Rho JY, Yagihashi K, Tate RM, Swigris JJ, Kern JA Tags: Chest Source Type: research

Endothelial Function in Children with Obstructive Sleep Apnea and the Effects of Adenotonsillectomy.
Conclusions:Children with OSA had reduced FMD which was reversible with treatment. Background: The association between childhood obstructive sleep apnea (OSA) and endothelial function as measured by flow-mediated dilation (FMD) and its response to OSA treatment are uncertain. Objective: To compare FMD in children with OSA with non-snoring controls and to examine its response to treatment. Methods: Index cases were children aged 6-18 years with habitual snoring and polysomnography (PSG) confirmed OSA [obstructive apnea hypopnea index (OAHI) of >1 events/h]. Each case was paired with an age, gender and body ma...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Chan KC, Au CT, Chook P, Lee DL, Lam HS, Wing YK, Li AM Tags: Chest Source Type: research

Transbronchial Versus Transesophageal Needle Aspiration Using an Ultrasound Bronchoscope for the Diagnosis of Mediastinal Lesions: A Randomized Study.
Conclusions:Both EBUS-TBNA and EUS-FNA provide high accuracy with good tolerance, though the occurrence of infectious complications should be monitored carefully. EUS-FNA has the advantage of comparable tolerance with fewer doses of anesthetics and sedatives, shorter procedure time, and fewer oxygen desaturations during the procedure. Trial registration:UMIN-Clinical Trials Registry; Identifier: UMIN000005757. Background: The purpose of this study was to compare the tolerance, efficacy and safety of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) versus transesophageal endoscopic ultrasound...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Oki M, Saka H, Ando M, Tsuboi R, Nakahata M, Oka S, Kogure Y, Kitagawa C Tags: Chest Source Type: research

Association between occupational dust exposure and prognosis of idiopathic pulmonary fibrosis: A Korean national survey.
Conclusion:These findings indicate that occupational dust may be an aggravating factor associated with a poor prognosis in IPF. Background: Previous studies have investigated the relationship between occupational and environmental agents and idiopathic pulmonary fibrosis (IPF). However, there have been few studies regarding the prognosis of IPF patients, according to patient occupation. Objective: We investigated whether occupational dust exposure was associated with clinically decreased lung function and poor prognosis. Design: The Korean Interstitial Lung Disease Research Group conducted a national survey to ...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Lee SH, Kim DS, Kim YW, Chung MP, Uh ST, Park CS, Jeong SH, Park YB, Lee HL, Song JS, Shin JW, Yoo NS, Lee EJ, Lee JH, Jegal Y, Lee HK, Park MS Tags: Chest Source Type: research

Health Literacy, Cognitive Function, Proper Use and Adherence to Inhaled Asthma Controller Medications among Older Adults with Asthma.
Conclusion:Among older asthmatics, interventions to promote proper medication use should seek to simplify tasks and patient roles in order to overcome cognitive load and suboptimal performance in self-care. Background: We sought to investigate the degree to which cognitive skills explain associations between health literacy and asthma-related medication use among older adults with asthma. Methods: Patients aged 60 years and older receiving care at 8 outpatient clinics (primary care, geriatrics, pulmonology, allergy and immunology) in New York, NY and Chicago, IL were recruited to participate in structured, in-perso...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: O'Conor R, Wolf MS, Smith SG, Martynenko M, Vicencio DP, Sano M, Wisnivesky JP, Federman AD Tags: Chest Source Type: research

The MUC5B promoter polymorphism is associated with IPF in a Mexican cohort but is rare among Asian ancestries.
Conclusions:The strongest identified genetic risk factor for IPF among the non-Hispanic white population, the MUC5B promoter polymorphism, is also a strong risk factor in a Mexican population, but is very rare in a Korean population. The majority of genetic variants that account for risk of IPF in groups other than non-Hispanic whites are unknown. Hispanic and Asian populations should be studied separately to identify genetic risk loci for IPF. Background: Polymorphisms in the MUC5B promoter, TOLLIP gene, and nine additional genetic loci have been associated with idiopathic pulmonary fibrosis (IPF) within non-Hispanic ...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Peljto AL, Selman M, Kim DS, Murphy E, Tucker L, Pardo A, Lee JS, Ji W, Schwarz MI, Yang IV, Schwartz DA, Fingerlin TE Tags: Chest Source Type: research

High Yield Of Bronchoscopic Trans-Parenchymal Nodule Access (BTPNA) -Real-Time Image-Guided Sampling In A Novel Model Of Small Pulmonary Nodules In Canines.
Conclusion:These canine studies demonstrate that BTPNA has the potential to achieve the high yield of Transthoracic Needle Aspiration (TTNA) with the low complication profile associated with traditional bronchoscopy. These results merit further study in humans. Introduction: Bronchoscopic Trans-Parenchymal Nodule Access (BTPNA) is a novel approach to accessing pulmonary nodules (PN). This real-time, image-guided approach was evaluated for safety, accuracy, and yield in the healthy canine model. Methods: A novel, inorganic model of sub-centimeter pulmonary nodules (PN) was developed, consisting of 0.25 cc aliquots o...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Sterman DH, Keast T, Rai L, Gibbs J, Wibowo H, Draper J, Herth FJ, Silvestri GA Tags: Chest Source Type: research

Change of the Junctions between Stations 10 and 4 by the New IASLC LN Map: A Validation Study from a Single Tertiary Referral Hospital Experience.
Conclusions:Changed definition between N1 and N2 diseases by IASLC LN map works well as expected in stratifying patient prognosis. Positive LN ratio may be more valuable than nodal stations involved in predicting patient survival in resectable NSCLC. Background: With International Association for the Study of Lung Cancer (IASLC) lymph node (LN) map, some tumors previously staged as N2 disease with Mountain Dresler-American Thoracic Society (MD-ATS) map, are staged as N1. We aimed to evaluate the effectiveness of IASLC LN map in stratifying patient prognosis in patients with non-small cell lung cancer (NSCLC) and LN met...
Source: Chest - October 2, 2014 Category: Respiratory Medicine Authors: Lee S, Lee HY, Lee KS, Yie M, Zo J, Shim YM, Han J, Ahn JH Tags: Chest Source Type: research

Association between annual river flood pulse and paediatric hospital admissions in the Mekong Delta area.
Abstract The Mekong Delta is the most vulnerable region to extreme climate and hydrological conditions however the association between these conditions and children׳s health has been little studied. We examine the association between annual river flood pulse and paediatric hospital admissions in a Vietnam Mekong Delta city. Daily paediatric hospital admissions (PHA) were collected from the City Paediatric Hospital, and daily river water level (RWL) and meteorological data were retrieved from the Southern Regional Hydro-Meteorological Centre from 2008 to 2011. We evaluated the association between annual river flood...
Source: Environmental Research - October 2, 2014 Category: Environmental Health Authors: Phung D, Huang C, Rutherford S, Chu C, Wang X, Nguyen M Tags: Environ Res Source Type: research

Sulfitobacter pseudonitzschiae sp. nov., isolated from toxic marine diatom Pseudo-nitzschia multiseries.
Abstract A taxonomic study was carried out on bacterial strain H3T, which was isolated from the toxic marine diatom Pseudo-nitzschia multiseries. Strain H3T was Gram-negative, rod-shaped, non-motile and capable of reducing nitrate to nitrite, but not denitrification. Growth was observed at NaCl concentrations of 1-9%, pH 6-12 and at temperatures from 10-37°C. It was unable to degrade aesculin or gelatin. The dominant fatty acids (more than 10%) were C18:1 ω7c/ω6c (summed feature 8) and C16:0. The respiratory ubiquinone was Q10. The major lipids were phosphatidylethanolamine, phosphatidylglycerol, aminolipid and ...
Source: International Journal of Systematic and Evolutionary Microbiology - October 2, 2014 Category: Microbiology Authors: Hong Z, Lai Q, Luo Q, Jiang S, Zhu R, Liang J, Gao Y Tags: Int J Syst Evol Microbiol Source Type: research

Desulfoprunum benzoelyticum gen. nov., sp. nov., a Gram-negative benzoate-degrading sulfate reducing bacterium isolated from a wastewater treatment plant.
Abstract A strictly anaerobic, mesophilic sulfate-reducing bacterium strain KoBa311T, isolated from the wastewater treatment plant at Konstanz, Germany, was characterized phenotypically and phylogenetically. Cells were Gram-negative, non-motile, oval to short rods, 3-5 µm long and 0.8-1.0 µm wide with rounded ends, dividing by binary fission and occurring singly or in pairs. The strain grew optimally in freshwater medium and the optimum temperature was 300C. Strain KoBa311T showed optimum growth at pH 7.3 -7.6. Organic electron donors were oxidised completely to carbon dioxide concomitant with sulfate reduction t...
Source: International Journal of Systematic and Evolutionary Microbiology - October 2, 2014 Category: Microbiology Authors: Junghare M, Schink B Tags: Int J Syst Evol Microbiol Source Type: research

Can the rolling cross-sectional survey design be used to estimate the effectiveness of influenza vaccines?
CONCLUSIONS: The rolling cross-sectional design is methodologically feasible and may be useful as a complement to clinic-based VE studies. This pilot study did not have sufficient power to detect significant vaccine effectiveness during a mild influenza season, but this approach may facilitate rapid estimation of VE in a pandemic setting when normal patterns of health care utilization are disrupted. PMID: 25284810 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - October 2, 2014 Category: Allergy & Immunology Authors: Donahue JG, Kieke BA, Szilagy PG, Blumkin AK, Hilgemann D, Dana Flanders W, Shay DK, Meece J, Gallivan S, Treanor J, Belongia EA Tags: Vaccine Source Type: research

High-Flow Nasal Cannula Oxygen in Adult Patients: A Narrative Review.
Abstract : High-flow nasal cannula oxygen (HFNC) is a relatively new therapeutic innovation being used in adults with severe respiratory disease. It delivers heated humidified oxygen through short nasal prongs and supplies much higher flow rates than traditional nasal cannula systems. These higher flows match patient flow demands better, reduce anatomic dead space and provide a slightly positive pressure in the upper airway. Randomized trials, nonrandomized prospective trials and case series using HFNC in adults were identified in the PubMed, Google Scholar and Cochrane databases for the period of June 1981 to Dece...
Source: The American Journal of the Medical Sciences - October 2, 2014 Category: Journals (General) Authors: Sotello D, Rivas M, Mulkey Z, Nugent K Tags: Am J Med Sci Source Type: research

[Value of routine identification of respiratory infectious agents in children hospitalized with an acute asthma exacerbation.]
CONCLUSION: These analyses do not seem to have a real advantage for the patient except for epidemiology. It would be important to conduct a new study analyzing the role of rhinovirus, and of other viruses such as coronavirus, bocavirus, and enterovirus, not routinely investigated in our hospital, and to question the value of these costly microbiological tests. PMID: 25284733 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - October 2, 2014 Category: Pediatrics Authors: Sauvaget E, Bresson V, Oudyi M, Bosdure E, Loundou AD, Chabrol B, Charrel R, Dubus JC Tags: Arch Pediatr Source Type: research

First report of severe parainfluenza virus 4B and rhinovirus C coinfection in a liver transplant recipient treated with immunoglobulin
We present the first case of severe lower respiratory tract infection due to human parainfluenza (HPIV) 4B, human rhinovirus (HRV) C coinfection in an adult liver transplant recipient, who showed excellent clinical response to intravenous immunoglobulin (IVIG). (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - October 2, 2014 Category: Virology Authors: Siddharth Sridhar, Hayes K.H. Luk, Susanna K.P. Lau, Patrick C.Y. Woo Tags: Case Report Source Type: research

Interactions of copper and thermal stress on mitochondrial bioenergetics in rainbow trout, Oncorhynchus mykiss.
Abstract Thermal stress may influence how organisms respond to concurrent or subsequent chemical, physical and biotic stressors. To unveil the potential mechanisms via which thermal stress modulates metals-induced bioenergetic disturbances, the interacting effects of temperature and copper (Cu) were investigated in vitro. Mitochondria isolated from rainbow trout livers were exposed to a range of Cu concentrations at three temperatures (5, 15 and 25°C) with measurement of mitochondrial complex I (mtCI)-driven respiratory flux indices and uncoupler-stimulated respiration. Additional studies assessed effects of tempe...
Source: Aquatic Toxicology - October 2, 2014 Category: Toxicology Authors: Sappal R, MacDonald N, Fast M, Stevens D, Kibenge F, Siah A, Kamunde C Tags: Aquat Toxicol Source Type: research

Sleep apnea in the elderly
This article uses literature to provide an outline on SAS observed in the elderly. Recent findings: SAS sufferers often have complications with so-called lifestyle-related diseases, such as hypertension, hyperlipidemia, diabetes mellitus and metabolic syndrome. These symptoms, along with SAS, recede as a result of continuous positive airway pressure treatment. Some have also reported recession of depression symptoms and delay in deterioration of cognitive functions. Summary: The elderly tends to develop SAS through coexistence of chronic respiratory organ disorders, increase in upper airway collapse, strokes, cardiovascula...
Source: Current Opinion in Psychiatry - October 1, 2014 Category: Psychiatry Tags: Edited by Orestes Forlenza and Claudia Cooper Source Type: research

Air pollution and respiratory health of school children in industrial, commercial and residential areas of Delhi
In this study, the respiratory health of school children belonging to three different localities namely industrial, commercial and residential areas of Delhi City was assessed by questionnaire survey and lung function test. The outdoor air pollution data from the National Ambient Air Quality Monitoring (NAAQM) stations was used for the study, which were located within 1-km distance from the selected school sites. Indoor air quality monitoring has also been done at classrooms for particulate matter (PM10), sulphur dioxide (SO2) and nitrogen oxides (NOx). Indoor and outdoor PM10 concentration at schools in commercial area (8...
Source: Air Quality, Atmosphere and Health - October 1, 2014 Category: Environmental Health Source Type: research

Complete genomic characterization of a porcine reproductive and respiratory syndrome virus isolate in Xinjiang province of China
Abstract Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of major economic importance that causes reproductive and respiratory problems in pigs. In the present study, one strain of porcine reproductive and respiratory syndrome virus (PRRSV) was isolated in Xinjiang province, Northwest China, designated XJu-1. The full-length genome of XJu-1 was found to be 14,987 nucleotides in length, including the poly(A) tail. Comparative analysis with the genomic sequences of type 2 isolates revealed that XJu-1 shared 87.2–99.2 % identity with these isolates, but only 60.4 % with the type 1 virus—...
Source: Virus Genes - October 1, 2014 Category: Genetics & Stem Cells Source Type: research

Ultra-minimally invasive cardiac surgery: robotic surgery and awake CABG
In this study, the potential of a new awake CABG protocol using only epidural anesthesia was investigated for realizing day surgery and was found to be a promising modality for ultra-minimally invasive cardiac surgery. We herein review robot-assisted cardiac surgery and awake off-pump coronary artery bypass grafting as ultra-minimally invasive cardiac surgeries. (Source: Surgery Today)
Source: Surgery Today - October 1, 2014 Category: Surgery Source Type: research

Evaluation of Circulating YKL-40 Levels in Idiopathic Interstitial Pneumonias
Conclusion YKL-40 is highly elevated in fibrotic interstitial pneumonias and may reflect the degree of activity of the fibrogenic process. Remarkably, levels remain high in IPF, but can decrease in other interstitial pneumonias, which appears to be related to a better prognosis. (Source: Lung)
Source: Lung - October 1, 2014 Category: Respiratory Medicine Source Type: research

Is hand-sewn anastomosis superior to stapled anastomosis following oesophagectomy?
Abstract A best evidence topic was written according to a structured protocol. The question addressed was: In patients undergoing oesophagectomy is stapled anastomosis (STA) superior to hand-sewn anastomosis (HSA) with respect to post-operative outcomes. In total, 82 papers were found suitable using the reported search and 14 of these represented the best evidence to answer the clinical question. The authors, date, journal, study type, population, main outcome measures and results are tabulated. Existing evidence shows that STA is associated with reduced time to anastomotic construction and decreased intra-operativ...
Source: Hand Surgery - October 1, 2014 Category: Surgery Authors: Kayani B, Garas G, Arshad M, Athanasiou T, Darzi A, Zacharakis E Tags: Int J Surg Source Type: research

Am J Respir Cell Mol Biol; +18 new citations
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Cell Mol Biol These pubmed results were generated on 2014/10/01PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - October 1, 2014 Category: Respiratory Medicine Tags: Report Source Type: research

Measuring gas exchange with step changes in inspired oxygen: an analysis of the assumption of oxygen steady state in patients suffering from COPD
This study shows that steady state oxygen levels may not be necessary when estimating pulmonary gas exchange using changes in FiO2. As such this technique may be applicable in patients with lung disease such as COPD. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - October 1, 2014 Category: Information Technology Source Type: research

The accuracy of respiratory rate assessment by doctors in a London teaching hospital: a cross-sectional study
This study aimed to assess the accuracy of the methods of RR measurement being used by doctors. A cross-sectional study assessing the accuracy (range, bias, and imprecision) of doctors’ ‘spot’ and ‘formal’ respiratory rate assessments, using videos of mock patients. 54 doctors in a London teaching hospital participated. Both methods showed high levels of inaccuracy, though formal methods were more accurate than ‘spot’ assessments. 52 and 19 % of doctors did not identify the respiratory rates shown as abnormal, using ‘spot’ and formal assessment methods respectively. We observed a trend towards decreasing...
Source: Journal of Clinical Monitoring and Computing - October 1, 2014 Category: Information Technology Source Type: research

Simvastatin in the Acute Respiratory Distress Syndrome
New England Journal of Medicine, Volume 0, Issue 0, Ahead of Print. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - October 1, 2014 Category: Internal Medicine Tags: article Source Type: research

Tidal Volume and Plateau Pressure Use for Acute Lung Injury From 2000 to Present: A Systematic Literature Review*
Conclusions: For clinicians treating acute lung injury since 2000, achieving VT less than or equal to 6 mL/kg predicted body weight may not have been as attainable or important as PPlat less than or equal to 30 cm H2O. If so, there may be equipoise to test if VT less than or equal to 6 mL/kg predicted body weight are necessary to improve acute lung injury outcome. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 1, 2014 Category: Emergency Medicine Tags: Review Article Source Type: research

Underuse Versus Equipoise for Low Tidal Volume Ventilation in Acute Respiratory Distress Syndrome: Is This the Right Question?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 1, 2014 Category: Emergency Medicine Tags: Editorials Source Type: research

Activation of Hypoxia-Inducible Factor-1α in Type 2 Alveolar Epithelial Cell Is a Major Driver of Acute Inflammation Following Lung Contusion*
Conclusion: Activation of hypoxia-inducible factor-1α in type 2 cell is a major driver of acute inflammation following lung contusion. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 1, 2014 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers
Purpose of reviewMiddle East respiratory syndrome coronavirus (MERS-CoV) is currently the focus of global attention. In this review, we describe virological, clinical, epidemiological features and interim travel advice and guidelines regarding MERS-CoV. We compare and contrast these with the severe acute respiratory syndrome coronavirus (SARS-CoV). Recent findingsMERS-CoV is a novel β CoV that causes a spectrum of clinical illness from asymptomatic to the rapidly fatal disease mainly in those with comorbid conditions. Epidemiological and genomic studies show zoonotic transmission to humans from camels and possibly bats. I...
Source: Current Opinion in Infectious Diseases - October 1, 2014 Category: Infectious Diseases Tags: TROPICAL AND TRAVEL-ASSOCIATED DISEASES: Edited by Joseph M. Vinetz and Yukari C. Manabe Source Type: research

The evidence for symptomatic treatments in amyotrophic lateral sclerosis
Discussion focuses predominantly on recently published articles. We cover management settings, disease-modifying treatment, vitamin D, respiratory management including noninvasive ventilation and diaphragmatic pacing, secretions, nutrition, dysphagia and gastrostomy, communication problems, mobility, spasticity, pain, cognition, depression and emotional lability, fatigue, sleep disturbance, head drop, prevention of deep venous thrombosis and end-of-life issues. Summary: Multidisciplinary specialist care appears to improve quality of life and survival. Riluzole remains the only available disease-modifying medication and con...
Source: Current Opinion in Neurology - October 1, 2014 Category: Neurology Tags: NERVE, NEURO-MUSCULAR JUNCTION AND MOTOR NEURON DISEASES: Edited by Kevin Talbot and Angela Vincent Source Type: research

Clinical and scientific aspects of muscle-specific tyrosine kinase-related myasthenia gravis
Purpose of review: Antibodies to muscle-specific tyrosine kinase (MuSK) characterize up to 5% of myasthenia gravis patients. This review focuses on the differences to clinical antiacetylcholine receptor-myasthenia gravis, and on the physiology and animal studies that elucidate the role of MuSK and help explain the clinical disease. Recent findings: MuSK forms the core of a protein complex in the postsynaptic membrane at the neuromuscular junction. During development, MuSK tyrosine kinase signaling is vital for the formation and stabilization of the postsynaptic endplate; it is now clear that long-term homeostasis of mature...
Source: Current Opinion in Neurology - October 1, 2014 Category: Neurology Tags: NERVE, NEURO-MUSCULAR JUNCTION AND MOTOR NEURON DISEASES: Edited by Kevin Talbot and Angela Vincent Source Type: research

Chronic obstructive pulmonary disease and the risk for ventilator-associated pneumonia
Purpose of reviewTo discuss recent data on the relationship between chronic obstructive pulmonary disease (COPD) and ventilator-associated pneumonia (VAP). Recent findingsDespite increased use of noninvasive ventilation, a large proportion of COPD patients still require invasive mechanical ventilation. Intubated COPD patients are at increased risk for VAP compared with patients without COPD. VAP is associated with increased mortality and duration of mechanical ventilation in these patients. Specific risk factors for VAP in this population include prolonged duration of invasive mechanical ventilation, high incidence of micr...
Source: Current Opinion in Critical Care - October 1, 2014 Category: Nursing Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman Source Type: research

Zinc deficiency and toxicity in pediatric practice
Purpose of reviewZinc is a commonly overlooked deficiency in developed countries, occurring in infants, children, and adolescents during critical growth periods. The purpose of this review is to present the evidence of zinc deficiencies and toxicities as well as treatment in pediatrics. Recent findingsDuring the last decade, the significance of zinc deficiency in childhood growth, morbidity, and mortality has been recognized by a number of large-scale supplementation trials in underdeveloped countries. Recognition of the recent nationwide shortage of injectable zinc available for total parenteral nutrition supplementation ...
Source: Current Opinion in Pediatrics - October 1, 2014 Category: Pediatrics Tags: GASTROENTEROLOGY AND NUTRITION: Edited by Robert Wyllie Source Type: research

Limiting acute respiratory distress syndrome in the emergency department: a survey of US academic emergency medicine physicians
No abstract available (Source: European Journal of Emergency Medicine)
Source: European Journal of Emergency Medicine - October 1, 2014 Category: Emergency Medicine Tags: Correspondence Source Type: research

Intensive Care Unit Admission in Children With Malignant or Nonmalignant Disease: Incidence, Outcome, and Prognostic Factors: A Single-Center Experience
Objective:To investigate pediatric intensive care unit (PICU) admission in children with malignant and nonmalignant diseases who developed life-threatening complications. Patients and Methods:Between 1999 and 2010, of the 1278 eligible pediatric patients treated for a malignant or nonmalignant disease, 54 were admitted to the PICU for respiratory distress (40.7%), neurological events (33.3%), severe sepsis (14.8%), and organ failure (11.2%). Results:Rate of PICU admission was 4.2%, with a 2-year cumulative incidence of 4.5%. Risk factors associated with higher cumulative incidence of PICU admission were older age at study ...
Source: Journal of Pediatric Hematology Oncology - October 1, 2014 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Advanced Sclerosis of The Chest Wall Skin Secondary to Chronic Graft-versus-Host Disease: A Case With Severe Restrictive Lung Defect
In conclusion, pulmonary cGvHD can present with restrictive changes related with the advanced sclerosis of the chest wall skin. Performing a fasciotomy or a scar revision for the rigid chest wall in selected patients may improve the patients ventilation. (Source: Journal of Pediatric Hematology Oncology)
Source: Journal of Pediatric Hematology Oncology - October 1, 2014 Category: Hematology Tags: Online Articles: Clinical and Laboratory Observations Source Type: research

The Burden of Single Virus and Viral Coinfections on Severe Lower Respiratory Tract Infections Among Preterm Infants: A Prospective Birth Cohort Study in Brazil
Conclusions:This study confirms the association of RSV alone or as a coinfection with severe LRTI and reinforces the importance of providing adequate prophylaxis for susceptible infants. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 1, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Bronchiolitis and Pneumonia Requiring Hospitalization in Young First Nations Children in Northern Ontario, Canada
We examined rates of LRTI in First Nations Canadian infants living in the Sioux Lookout Zone, in Northern Ontario. Methods:A retrospective review of hospital admissions for LRTI during a 5-year period, in patients (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 1, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Respiratory Artifact on EEG Independent of the Respirator
Abstract:Recognizing EEG artifacts is important to correctly interpret and avoid unnecessary intervention. EEG artifacts from mechanical ventilation have been described as periodic, frontally maximal high amplitude waveforms, occurring at the same rate as the ventillator. Here, we describe a non-periodic respiratory artifact that was independent of the ventilator rate. The concomitant use of audio was helpful in identifying this artifact. (Source: Journal of Clinical Neurophysiology)
Source: Journal of Clinical Neurophysiology - October 1, 2014 Category: Neurology Tags: Case Report Source Type: research

Monitoring Sedation in Patients Receiving Opioids for Pain Management
Excessive sedation precedes opioid-induced respiratory depression. An evidence-based practice project standardized systematic sedation monitoring by nurses using an opioid sedation scale and respiratory assessment when opioids are administered for pain management. Nurses were educated and documentation updated. Nurses demonstrated increased ability to identify at-risk patients (3.2 pre-implementation; 3.6 post-implementation; 1-4 Likert scale) and reported understanding the tool to assess for oversedation (2.6 pre-implementation; 3.2 post-implementation). Documentation compliance improved, and patient safety was maintained...
Source: Journal of Nursing Care Quality - October 1, 2014 Category: Nursing Tags: Articles Source Type: research

Seronegative granulomatous polyangiitis with central retinal artery occlusion as the initial manifestation
Conclusion:Granulomatous polyangiitis is a multisystem vasculitic disorder. Central retinal artery occlusion as the presenting manifestation of GP is very uncommon. This report demonstrates the difficulty of diagnosing GP, particularly when initial diagnostic assays (including both serology and biopsy) were negative for GP. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - October 1, 2014 Category: Opthalmology Tags: Pacific Retina Club: Case Report Source Type: research

Multiple bilateral branch retinal artery occlusions in a patient with sickle cell disease with vancomycin red man syndrome
Conclusion:Retinal artery occlusion is a rare but potentially devastating complication of sickle cell disease. The potential for complications from vancomycin infusion during acute sickle crisis should be considered, although further study is warranted. (Source: Retinal Cases and Brief Reports)
Source: Retinal Cases and Brief Reports - October 1, 2014 Category: Opthalmology Tags: Pacific Retina Club: Case Report Source Type: research