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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Current Disease and Epidemiologic Problems: What ’s Hot?
Publication date: May–July 2015 Source:New Horizons in Translational Medicine, Volume 2, Issues 4–5 Author(s): CH Calisher Included among the many current world problems are viral diseases of considerable significance and threat. This talk could not possible cover them all but will discuss the emergence of Middle East respiratory syndrome in Saudi Arabia and nearby countries, ebolavirus hemorrhagic fever in West Africa, chikungunya in the Western Hemisphere, and the re-emergence of poliomyelitis. (Source: New Horizons in Translational Medicine)
Source: New Horizons in Translational Medicine - July 21, 2016 Category: Research Source Type: research

Airway stenting in the management of iatrogenic tracheal injuries: 10 ‐Year experience
ConclusionConservative management should be considered in non‐ventilated patients with ITI and when ITI is located in the upper trachea of ventilated patients where ETT or TC bypasses the injury. Airway stenting should be considered in ventilated patients with ITI located in the lower trachea. Surgery should be reserved for TEF and conservative and endoscopic management failure. (Source: Respirology)
Source: Respirology - July 21, 2016 Category: Respiratory Medicine Authors: Rachid Tazi ‐Mezalek, Ali I. Musani, Sophie Laroumagne, Philippe J. Astoul, Xavier B. D'journo, Pascal A. Thomas, Hervé Dutau Tags: Original Article Source Type: research

Clinically remitted childhood asthma is associated with airflow obstruction in middle ‐aged adults
ConclusionClinically remitted childhood asthma is associated with airflow obstruction in middle‐aged adults. Smoking and remitted childhood asthma may be additive factors for the development of airflow obstruction. (Source: Respirology)
Source: Respirology - July 21, 2016 Category: Respiratory Medicine Authors: Keitaro Omori, Hiroshi Iwamoto, Takashi Yamane, Taku Nakashima, Yoshinori Haruta, Noboru Hattori, Akihito Yokoyama, Nobuoki Kohno Tags: Original Article Source Type: research

Editorial Board, Masthead, TOC
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 21, 2016 Category: Respiratory Medicine Tags: Issue Information Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 21, 2016 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Innovative Tuberculosis Symposium held during Cuba Salud 2015
The Tuberculosis (TB) Symposium, held during the Cuba Salud 2015 International Convention, highlighted advancements in research on tuberculosis (TB) and Mycobacterium tuberculosis (MTBtb) by interdisciplinary teams from academic and federal institutions in Cuba, Colombia, Mexico, and the Dominican Republic. Delegates focused on the targets presented in the World Health Organization End TB Strategy for 2016-2035 and elaborated on four primary themes: 1) attention to vulnerable populations such as immunocompromised individuals, health care workers, and residents of long-term institutions such as prisons and nursing homes; 2)...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Helena J. Chapman, Luisa Armas P érez Tags: Editorial Source Type: research

Safety and immunogenicity of the M72/AS01E candidate tuberculosis vaccine in adults with tuberculosis: a phase II randomised study
Previous studies have shown that the M72/AS01E candidate tuberculosis vaccine is immunogenic with a clinically acceptable safety profile in healthy and Mycobacterium tuberculosis-infected adults. This phase II, observer-blind, randomised study compared the safety, reactogenicity, and immunogenicity of M72/AS01E in 3 cohorts: tuberculosis-na ïve adults (n=80), adults previously treated for tuberculosis (n=49), and adults who have completed the intensive phase of tuberculosis treatment (n=13).In each cohort, 18–59-year-old adults were randomised (1:1) to receive two doses of M72/AS01E (n=71) or placebo (n=71) and followed...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Paul Gillard, Pan-Chyr Yang, Manfred Danilovits, Wei-Juin Su, Shih-Lung Cheng, Lea Pehme, Anne Bollaerts, Erik Jongert, Philippe Moris, Opokua Ofori-Anyinam, Marie-Ange Demoiti é, Marcela Castro Tags: Immunological Aspects Source Type: research

TBDRUGS - Database of Drugs for Tuberculosis
Tuberculosis (TB) continues to be a major killer disease worldwide, though it can be cured completely. Emergence of drug resistant tuberculosis (DR-TB) has made TB treatment a complex one, demanding intake of medicine for about 2 years versus 6 months for drug-sensitive tuberculosis. Further, the success rate of treatment of DR-TB is reported to be very poor (48%) as compared to drug-sensitive new TB cases (around 90%) [1]. However, the recent approval of bedaquiline and delamanid for use against drug resistant tuberculosis, and the prospect of several candidate drugs in the pipeline with demonstrated activity against DR-T...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Jagadish Chandrabose Sundaramurthi, Luke Elizabeth Hanna, Sriram Selvarajulu, Sridharan Brindha, Joel Gnanadoss J, Savariar Vincent, Harpreet Singh, Soumya Swaminathan Tags: Letter to the Editor Source Type: research

Diagnostic and prognostic significance of receptor ‐binding cancer antigen expressed on SiSo cells in lung‐cancer‐associated pleural effusion
ConclusionIn conclusion, measurement of sRCAS1 might be a useful diagnostic and prognostic marker for MPE. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 21, 2016 Category: Respiratory Medicine Authors: Jian Yang, Ying Zhu, Liangquan Wu, Wenyan Zhu, Xiuwei Zhang, Yang Yang, Chunhua Xu Tags: Original Article Source Type: research

Determinants of delay in tuberculosis diagnosis in Hamadan province, 2006 −2014
Conclusion A high proportion of patients had delays in diagnosis exceeding three months. Our findings suggest that male gender, new cases, positive and extra pulmonary cases might increase the risk for delayeddiagnosis among TB patients. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - July 21, 2016 Category: Respiratory Medicine Source Type: research

Sputum –plasma ratio of soluble receptor for advanced glycation end-products in patients with chronic obstructive pulmonary disease
Conclusions sRAGE level either in induced sputum, plasma or sputum plasma ratio is not significantly different between stable COPD patients, smokers and healthy controls. Thus, sRAGE cannot be considered as a marker of either diagnosis or severity of COPD. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - July 21, 2016 Category: Respiratory Medicine Source Type: research

Pulmonary tuberculosis epidemiology in Coimbra's District (2000 –2011): Information is essential to understand high risk groups
Publication date: July–August 2016 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 22, Issue 4 Author(s): R. Eufrásio, M. Alcobia, L. Correia (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 21, 2016 Category: Respiratory Medicine Source Type: research

Pleural effusion cytology due to malignancy. A combined cytomorphological –immunocytochemical study of 500 cases
Publication date: Available online 20 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): A. Kalogeraki, D. Tamiolakis, G. Datseri, G. Lazopoulos, M. Karvelas-Kalogerakis, J. Segredakis, I. Zoi (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 21, 2016 Category: Respiratory Medicine Source Type: research

A case of Birt –Hogg–Dubé syndrome
Publication date: Available online 14 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): L. Martins, M. Caixeiro, C. Costa, S. Feijó, C. Bárbara (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 21, 2016 Category: Respiratory Medicine Source Type: research

Simulated Trauma and Resuscitation Team Training course —evolution of a multidisciplinary trauma crisis resource management simulation course
Conclusions The evolved Simulated Trauma and Resuscitative Team Training curriculum has maintained high participant satisfaction and is associated with improvement in team crisis resource management skills over the duration of the course. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - July 21, 2016 Category: Surgery Source Type: research

Extracorporeal Membrane Oxygenation —What the Nephrologist Needs to Know
Publication date: May 2016 Source:Advances in Chronic Kidney Disease, Volume 23, Issue 3 Author(s): Andres Oswaldo Razo-Vazquez, Kevin Thornton Extracorporeal membrane oxygenation (ECMO) use in adults is rapidly increasing in its use for both cardiac and respiratory failure. ECMO exists in 2 primary configurations: veno-venous ECMO, used in the setting of isolated respiratory failure, and veno-arterial ECMO, which can be used in respiratory failure but is mandatory in the setting of cardiac failure. Acute kidney injury occurs frequently in patients on ECMO, and renal replacement therapy is often required. Continuous fo...
Source: Advances in Chronic Kidney Disease - July 21, 2016 Category: Urology & Nephrology Source Type: research

Fractional Exhaled Nitric Oxide for the Diagnosis of Childhood Asthma: a Systematic Review and Meta-analysis
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > The gold standard for diagnosing asthma in children is based on clinical history of respiratory symptoms, physical examination, and respiratory function testing. Recent advances indicate that a non-invasive measure of airway inflammation, fractional exhaled nitric oxide (FeNO), provides objective data for use in asthma diagnosis. However, the diagnostic performance of FeNO in children with asthma has not been clearly defined. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of FeNO in the clinical determination of ...
Source: Clinical Reviews in Allergy and Immunology - July 21, 2016 Category: Allergy & Immunology Source Type: research

Lung Function Abnormalities in Smokers With Ischemic Heart Disease.
CONCLUSIONS: Airflow limitation compatible with chronic obstructive pulmonary disease affects almost one-third of patients with ischemic heart disease. While airflow limitation is associated with additional morbidity and societal burden, it is largely undiagnosed and untreated. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01485159. PMID: 27442601 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 21, 2016 Category: Respiratory Medicine Authors: Franssen FM, Soriano JB, Roche N, Bloomfield PH, Brusselle G, Fabbri LM, García-Rio F, Kearney MT, Kwon N, Lundbäck B, Rabe KF, Raillard A, Muellerova H, Cockcroft JR Tags: Am J Respir Crit Care Med Source Type: research

Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction
The loss of strength in combination with constant fatigue is a burden on cancer patients undergoing chemotherapy. Doxorubicin, a standard chemotherapy drug used in the clinic, causes skeletal muscle dysfunction and increases mitochondrial H2O2. We hypothesized that the combined effect of cancer and chemotherapy in an immunocompetent breast cancer mouse model (E0771) would compromise skeletal muscle mitochondrial respiratory function, leading to an increase in H2O2-emitting potential and impaired muscle function. Here, we demonstrate that cancer chemotherapy decreases mitochondrial respiratory capacity supported with comple...
Source: AJP: Endocrinology and Metabolism - July 21, 2016 Category: Endocrinology Authors: Gilliam, L. A. A., Lark, D. S., Reese, L. R., Torres, M. J., Ryan, T. E., Lin, C.-T., Cathey, B. L., Neufer, P. D. Tags: Call for Papers Source Type: research

Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function
Although theoretically sound, the accuracy and precision of 31P-magnetic resonance spectroscopy (31P-MRS) approaches to quantitatively estimate mitochondrial capacity are not well documented. Therefore, employing four differing models of respiratory control [linear, kinetic, and multipoint adenosine diphosphate (ADP) and phosphorylation potential], this study sought to determine the accuracy and precision of 31P-MRS assessments of peak mitochondrial adenosine-triphosphate (ATP) synthesis rate utilizing directly measured peak respiration (State 3) in permeabilized skeletal muscle fibers. In 23 subjects of different fitness ...
Source: AJP: Endocrinology and Metabolism - July 21, 2016 Category: Endocrinology Authors: Layec, G., Gifford, J. R., Trinity, J. D., Hart, C. R., Garten, R. S., Park, S. Y., Le Fur, Y., Jeong, E.-K., Richardson, R. S. Tags: Articles Source Type: research

Hospital Surveillance of Influenza Strains: A Concordant Image of Viruses Identified by the Swiss Sentinel System?
CONCLUSIONS: Although an influenza surveillance system based on the community can predict the type of influenza strains that will be associated with hospitalizations, it fails to estimate the potential virulence of circulating strains. Further, the population characteristics in the community differ from those in hospitalized patients. This suggests that any national influenza surveillance system should include both community and hospital-based surveys. This article is protected by copyright. All rights reserved. PMID: 27441401 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 21, 2016 Category: Respiratory Medicine Authors: Gonçalves AR, Iten A, Suter-Boquete P, Schibler M, Kaiser L, Cordey S Tags: Influenza Other Respir Viruses Source Type: research

Epidemiology and Clinical Characteristics of Respiratory Syncytial Virus Infections among Children and Adults in Mexico.
CONCLUSIONS: This study confirms that RSV is an important respiratory pathogen in children in Mexico. In addition, a substantial number of cases in adults were also detected highlighting the relevance of this virus in all ages. It is important to identify subjects at high risk of complications who may benefit from current or future preventive interventions. This article is protected by copyright. All rights reserved. PMID: 27439650 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 21, 2016 Category: Respiratory Medicine Authors: Gamiño-Arroyo AE, Moreno-Espinosa S, Llamosas-Gallardo B, Ortiz-Hernández AA, Guerrero ML, Galindo-Fraga A, Galán-Herrera JF, Prado-Galbarro FJ, Beigel JH, Ruiz-Palacios GM, Noyola DE, Mexico Emerging Infectious Diseases Clinical Research Network (La R Tags: Influenza Other Respir Viruses Source Type: research

Benefit of Early Initiation of Influenza Antiviral Treatment to Pregnant Women Hospitalized With Laboratory-Confirmed Influenza
Conclusions. Early initiation of influenza antiviral treatment to pregnant women hospitalized with influenza may reduce the length of stay, especially among those with severe influenza. Influenza during pregnancy is associated with maternal and infant morbidity, and annual influenza vaccination is warranted. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - July 21, 2016 Category: Infectious Diseases Authors: Oboho, I. K., Reed, C., Gargiullo, P., Leon, M., Aragon, D., Meek, J., Anderson, E. J., Ryan, P., Lynfield, R., Morin, C., Bargsten, M., Zansky, S. M., Fowler, B., Thomas, A., Lindegren, M. L., Schaffner, W., Risk, I., Finelli, L., Chaves, S. S. Tags: VIRUSES Source Type: research

Robust Cytokine and Chemokine Response in Nasopharyngeal Secretions: Association With Decreased Severity in Children With Physician Diagnosed Bronchiolitis
Conclusions. The cytokines and chemokines significantly associated with decreased bronchiolitis severity are classified in a wide range of functional groups (T-helper 1 and 2, regulatory, and chemoattractant). The involvement of these functional groups suggest that a broadly overlapping cytokine/chemokine response is required for control of virus-mediated respiratory disease in young children. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - July 21, 2016 Category: Infectious Diseases Authors: Nicholson, E. G., Schlegel, C., Garofalo, R. P., Mehta, R., Scheffler, M., Mei, M., Piedra, P. A. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research

Distinguishing the associations between daily mortality and hospital admissions and nitrogen dioxide from those of particulate matter: a systematic review and meta-analysis
Conclusions The association between short-term exposure to NO2 and adverse health outcomes is largely independent of PM mass. Further studies should attempt to investigate whether this is a generic PM effect or whether it is modified by the source and physicochemical characteristics of PM. This finding strengthens the argument for NO2 having a causal role in health effects. (Source: BMJ Open)
Source: BMJ Open - July 21, 2016 Category: Journals (General) Authors: Mills, I. C., Atkinson, R. W., Anderson, H. R., Maynard, R. L., Strachan, D. P. Tags: Open access, Epidemiology, Occupational and environmental medicine, Public health Research Source Type: research

A Comprehensive Review of Common Respiratory Infections Encountered in Urgent and Primary Care: A Reference Guide for Judicious Antibiotic Use with Complementary Therapies
Concern about antibiotic overuse has become heightened as bacterial resistance to antibiotics continues to increase. Patients experiencing respiratory symptoms frequently present to urgent/emergent care settings such as fast-track emergency care departments and primary care retail settings with the expectation that they will be prescribed antibiotics. The Centers for Disease Control and Prevention (CDC) reports that approximately 2 million people will become ill with bacteria that are resistant to at least one antibiotic, approximately 23,000 people die as a direct result of these infections, and many others die as a resul...
Source: Journal of Emergency Nursing: JEN - July 21, 2016 Category: Nursing Authors: Courtney Beam, Joyce Fuss, Wendy Stoelting-Gettelfinger Tags: Clinical Source Type: research

Central neural control of the cardiovascular system: current perspectives
This brief review, which is based on a lecture presented at the American Physiological Society Teaching Refresher Course on the Brain and Systems Control as part of the Experimental Biology meeting in 2015, aims to summarize current concepts of the principal mechanisms in the brain that regulate the autonomic outflow to the cardiovascular system. Such cardiovascular regulatory mechanisms do not operate in isolation but are closely coordinated with respiratory and other regulatory mechanisms to maintain homeostasis. The brain regulates the cardiovascular system by two general means: 1) feedforward regulation, often referred...
Source: AJP: Advances in Physiology Education - July 21, 2016 Category: Universities & Medical Training Authors: Dampney, R. A. L. Tags: REFRESHER COURSE Source Type: research

First-year medical students' naïve beliefs about respiratory physiology
The present study explored the nature and frequency of physiology naïve beliefs by investigating novices' understanding of the respiratory system. Previous studies have shown considerable misconceptions related to physiology but focused mostly on specific physiological processes of normal respiration. Little is known about novices' broader understanding of breathing in a clinical context. Our study hypothesized that naïve beliefs could hamper participants' ability to understand the interrelatedness of respiratory structures and functions related to breathing during a clinical complication. The study entaile...
Source: AJP: Advances in Physiology Education - July 21, 2016 Category: Universities & Medical Training Authors: Badenhorst, E., Mamede, S., Abrahams, A., Bugarith, K., Friedling, J., Gunston, G., Kelly-Laubscher, R., Schmidt, H. G. Tags: HOW WE TEACH: CLASSROOM AND LABORATORY RESEARCH PROJECTS Source Type: research

The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation.
This article is protected by copyright. All rights reserved. PMID: 27441396 [PubMed - as supplied by publisher] (Source: Immunology)
Source: Immunology - July 21, 2016 Category: Allergy & Immunology Authors: Yadava K, Bollyky P, Lawson MA Tags: Immunology Source Type: research

Highly Immunogenic Trimethyl Chitosan-Based Delivery System for Intranasal Lipopeptide Vaccines against Group A Streptococcus.
Abstract Group A streptococcus (GAS) infections can led to a large variety of diseases in humans including the most common acute pharyngitis. If untreated, GAS infections lead to life- threatening conditions such as rheumatic heart diseases and post-streptococcal glomerulonephritis. GAS primarily colonises the mucosal region of the upper respiratory tract, slowly leading to systemic infections. Thus, GAS-specific antibody responses are desirable at mucosal sites for early prevention against GAS colonisation. Although several GAS vaccines are currently in clinical trials, these vaccines aim to stimulate systemic imm...
Source: Current Drug Delivery - July 21, 2016 Category: Drugs & Pharmacology Authors: Skwarczynski M, Abdulghaffar K, Giddam AK, Batzloff M, Good M, Toth I Tags: Curr Drug Deliv Source Type: research

Retrospective review of critical incidents in the post-anaesthesia care unit at a major tertiary hospital.
CONCLUSION: A wide spectrum of critical incidents occurs in the PACU, many of which were related to the cardiovascular and respiratory systems. Critical incidents have a major impact on healthcare utilisation and result in prolonged PACU stays and higher levels of postoperative care than initially anticipated. PMID: 27439784 [PubMed - as supplied by publisher] (Source: Singapore Medical Journal)
Source: Singapore Medical Journal - July 21, 2016 Category: Journals (General) Authors: Bruins SD, Leong PM, Ng SY Tags: Singapore Med J Source Type: research

Airborne virus detection by a sensing system using a disposable integrated impaction device
There are many respiratory infections such as influenza that cause epidemics. These respiratory infection epidemics can be effectively prevented by determining the presence or absence of infections in patients using frequent tests. We think that self-diagnosis may be possible using a system that can collect and detect biological aerosol particles in the patient ’s breath because breath sampling is easy work requiring no examiner. In this paper, we report a sensing system for biological aerosol particles (SSBAP) with a disposable device. Using the system and the device, someone with no medical knowledge or skills ca...
Source: Journal of Breath Research - July 21, 2016 Category: Respiratory Medicine Authors: Kei Takenaka, Shigenori Togashi, Ryo Miyake, Takemasa Sakaguchi and Michihiro Hide Source Type: research

Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection
The gastric pathogen Helicobacter pylori utilizes molecular hydrogen (H 2 ) as a respiratory substrate during colonization in the gastric mucosa. However, the link between molecular H 2 and the pathogenesis of peptic-ulcer disease (PUD) and non-ulcerous dyspepsia (NUD) by the enzymatic activity of H. pylori still remains mostly unknown. Here we provide evidence that breath H 2 excretion profiles are distinctly altered by the enzymatic activity of H. pylori for individuals with NUD and PUD. We subsequently unravelled the potential molecular mechanisms responsible for the alteration of H 2 in exhaled breath in associat...
Source: Journal of Breath Research - July 21, 2016 Category: Respiratory Medicine Authors: Abhijit Maity, Mithun Pal, Sanchi Maithani, Barnali Ghosh, Sujit Chaudhuri and Manik Pradhan Source Type: research

Hypertensive disorders of pregnancy.
CONCLUSIONS: Hypertensive disorders of pregnancy are on the rise worldwide, and this trend is expected to continue. The major contributors to maternal mortality are failure to recognize HDP promptly or to treat the condition adequately. It is essential that anesthesiologists understand the disease process and acquire knowledge of the guidelines governing current obstetrical care in order to provide evidence-based multidisciplinary quality care to these patients. Anesthetic management helps prevent potentially deleterious maternal and fetal outcomes. PMID: 27443376 [PubMed - as supplied by publisher] (Source: Canadian J...
Source: Canadian Journal of Anaesthesia - July 21, 2016 Category: Anesthesiology Authors: Sjaus A, McKeen DM, George RB Tags: Can J Anaesth Source Type: research

Mode of anesthesia and clinical outcomes of patients undergoing Cesarean delivery for invasive placentation: a retrospective cohort study of 50 consecutive cases.
CONCLUSION: Having safely performed two-thirds of our cases of CHyst under RA, our study suggests that RA, when compared with GA, is associated with no differences in blood loss or blood transfusion, superior neonatal outcome, and fewer respiratory complications. This suggests that RA can be considered a primary mode of anesthesia for such cases. PMID: 27443374 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - July 21, 2016 Category: Anesthesiology Authors: Nguyen-Lu N, Carvalho JC, Kingdom J, Windrim R, Allen L, Balki M Tags: Can J Anaesth Source Type: research

TBDRUGS – Database of drugs for tuberculosis
Tuberculosis (TB) continues to be a major killer disease worldwide, though it can be cured completely. Emergence of drug resistant tuberculosis (DR-TB) has made TB treatment a complex one, demanding intake of medicine for about 2 years versus 6 months for drug-sensitive tuberculosis. Further, the success rate of treatment of DR-TB is reported to be very poor (48%) as compared to drug-sensitive new TB cases (around 90%) [1]. However, the recent approval of bedaquiline and delamanid for use against drug resistant tuberculosis, and the prospect of several candidate drugs in the pipeline with demonstrated activity against DR-T...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Jagadish Chandrabose Sundaramurthi, Luke Elizabeth Hanna, Sriram Selvarajulu, Sridharan Brindha, J. Joel Gnanadoss, Savariar Vincent, Harpreet Singh, Soumya Swaminathan Tags: Letter to the Editor Source Type: research

Innovative Tuberculosis Symposium held during Cuba Salud 2015
The Tuberculosis (TB) Symposium, held during the Cuba Salud 2015 International Convention, highlighted advancements in research on tuberculosis (TB) and Mycobacterium tuberculosis (Mtb) by interdisciplinary teams from academic and federal institutions in Cuba, Colombia, Mexico, and the Dominican Republic. Delegates focused on the targets presented in the World Health Organization End TB Strategy for 2016 –2035 and elaborated on four primary themes: 1) attention to vulnerable populations such as immunocompromised individuals, health care workers, and residents of long-term institutions such as prisons and nursing homes; 2...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Helena J. Chapman, Luisa Armas P érez Tags: Editorial Source Type: research

Safety and immunogenicity of the M72/AS01E candidate tuberculosis vaccine in adults with tuberculosis: A phase II randomised study
Previous studies have shown that the M72/AS01E candidate tuberculosis vaccine is immunogenic with a clinically acceptable safety profile in healthy and Mycobacterium tuberculosis-infected adults. This phase II, observer-blind, randomised study compared the safety, reactogenicity, and immunogenicity of M72/AS01E in 3 cohorts: tuberculosis-na ïve adults (n = 80), adults previously treated for tuberculosis (n = 49), and adults who have completed the intensive phase of tuberculosis treatment (n = 13). (Source: Tuberculosis)
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Paul Gillard, Pan-Chyr Yang, Manfred Danilovits, Wei-Juin Su, Shih-Lung Cheng, Lea Pehme, Anne Bollaerts, Erik Jongert, Philippe Moris, Opokua Ofori-Anyinam, Marie-Ange Demoiti é, Marcela Castro Tags: Immunological Aspects Source Type: research

TBDRUGS – Database of drugs for tuberculosis
Tuberculosis (TB) continues to be a major killer disease worldwide, though it can be cured completely. Emergence of drug resistant tuberculosis (DR-TB) has made TB treatment a complex one, demanding intake of medicine for about 2 years versus 6 months for drug-sensitive tuberculosis. Further, the success rate of treatment of DR-TB is reported to be very poor (48%) as compared to drug-sensitive new TB cases (around 90%) [1]. However, the recent approval of bedaquiline and delamanid for use against drug resistant tuberculosis, and the prospect of several candidate drugs in the pipeline with demonstrated activity against DR-T...
Source: Tuberculosis - July 21, 2016 Category: Respiratory Medicine Authors: Jagadish Chandrabose Sundaramurthi, Luke Elizabeth Hanna, Sriram Selvarajulu, Sridharan Brindha, J. Joel Gnanadoss, Savariar Vincent, Harpreet Singh, Soumya Swaminathan Tags: Letter to the Editor Source Type: research

Identification of novel reaction products of methylene-biS-phenylisocyanate ("MDI") with oxidized glutathione in aqueous solution and also during incubation of MDI with a murine hepatic S9 fraction.
This study also investigated transformational changes in MDI after incubation with an S9 fraction prepared from murine liver. LC-MS analyses of the S9 reaction products revealed the formation of [M+H](+) ions with m/z's and retention times identical to the newly described GSSG-MDI (837 and 863) conjugates and the previously described mono(GSH)-MDI conjugates. Together the data identify novel biological transformations of MDI, which could have implications for exposure-related health effects, and may help target future in vivo studies of metabolism. PMID: 27453132 [PubMed - as supplied by publisher] (Source: Toxicology in Vitro)
Source: Toxicology in Vitro - July 21, 2016 Category: Toxicology Authors: Wisnewski AV, Liu J, Nassar AF Tags: Toxicol In Vitro Source Type: research

The potential adjuvanticity of quaternized chitosan hydrogel based microparticles for porcine reproductive and respiratory syndrome virus inactivated vaccine.
Abstract Infectious diseases possess a big threat to the livestock industry worldwide. Currently, inactivated veterinary vaccines have attracted much attention to prevent infection due to their safer profile compared to live attenuated vaccine. However, its intrinsic poor immunogenicity demands the incorporation of an adjuvant. Mineral oil based adjuvant (Montanide™ ISA206) was usually used to potentiate the efficacy of veterinary vaccines. However, ISA206 could not induce robust cellular immune responses, which was very important in controlling virus replication and clearing the infected cells. Moreover, mineral...
Source: International Immunopharmacology - July 21, 2016 Category: Allergy & Immunology Authors: Wang YQ, Liu Y, Wu YJ, Jia PY, Shan JJ, Wu J, Ma GH, Su ZG Tags: Int Immunopharmacol Source Type: research

Adaptive immune response to whole cell pertussis vaccine reflects vaccine quality: A possible complementation to the Pertussis Serological Potency test.
This study demonstrates that assessment of the magnitude of Th cell responses and the antigen specificity of antibodies induced by wP vaccination could form valuable complementary parameters to the PSPT. PMID: 27452867 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 21, 2016 Category: Allergy & Immunology Authors: Hoonakker ME, Verhagen LM, van der Maas L, Metz B, Uittenbogaard JP, van de Waterbeemd B, van Els CA, van Eden W, Hendriksen CF, Sloots A, Han WG Tags: Vaccine Source Type: research

Allergy in urban elderly population living in Campania region (Southern Italy). A multicenter study.
In conclusion, the prevalence and clinical significance of airway allergic sensitization in the elderly living in Campania region is more significant than expected in latter stages of life. Physicians should not neglect the role of atopy as a risk factor for the onset of allergic respiratory symptoms even in elderly patients. PMID: 27425174 [PubMed - in process] (Source: European Annals of Allergy and Clinical Immunology)
Source: European Annals of Allergy and Clinical Immunology - July 20, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Near fatal asthma: treatment and prevention.
Authors: D'Amato G, Vitale C, Lanza M, Sanduzzi A, Molino A, Mormile M, Vatrella A, Bilò MB, Antonicelli L, Bresciani M, Micheletto C, Vaghi A, D'Amato M Abstract Near-fatal asthma (NFA) is described as acute asthma associated with a respiratory arrest or arterial carbon dioxide tension greater than 50 mmHg, with or without altered consciousness, requiring mechanical ventilation. Risk factors for near fatal asthma have not been fully elucidated. In 80-85% of all fatal events, a phenotype, characterized by eosinophilic inflammation associated with gradual deterioration occurring in patients with severe and poorly c...
Source: European Annals of Allergy and Clinical Immunology - July 20, 2016 Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research

Historical ambient airborne asbestos concentrations in the United States.
Authors: Finkelstein MM PMID: 27427157 [PubMed - as supplied by publisher] (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 20, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research