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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Dipeptidyl Peptidase 4 Distribution in the Human Respiratory Tract
Dipeptidyl peptidase 4 (DPP4, CD26), a type II transmembrane ectopeptidase, is the receptor for the Middle Eastern respiratory syndrome coronavirus (MERS-CoV). MERS emerged in 2012 and has a high mortality associated with severe lung disease. A lack of autopsy studies from MERS fatalities has hindered understanding of MERS-CoV pathogenesis. We investigated the spatial and cellular localization of DPP4 to evaluate an association MERS clinical disease. DPP4 was rarely detected in the surface epithelium from nasal cavity to conducting airways with a slightly increased incidence in distal airways. (Source: American Journal of Pathology)
Source: American Journal of Pathology - November 17, 2015 Category: Pathology Authors: David K. Meyerholz, Allyn M. Lambertz, Paul B. McCray Tags: Regular Article Source Type: research

Respiratory syncytial virus activity and climate parameters during a 12‐year period
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - November 17, 2015 Category: Virology Authors: N. Sirimi, M. Miligkos, F. Koutouzi, E. Petridou, T. Siahanidou, A. Michos Tags: Research Article Source Type: research

Oxidative Modifications of Protein Tyrosyl Residues are Increased in Plasma of Human Subjects with Interstitial Lung Disease.
CONCLUSIONS: We demonstrate an increase in oxidized tyrosine moieties within proteins in the circulating plasma of ILD patients. These data support the potential for development of oxidative stress-related biomarkers in early diagnosis, prognostication, and/or in evaluating responsiveness to emerging therapies for ILD. PMID: 26575972 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 17, 2015 Category: Respiratory Medicine Authors: Pennathur S, Vivekanandan-Giri A, Locy ML, Kulkarni T, Zhi D, Zeng L, Byun J, de Andrade JA, Thannickal VJ Tags: Am J Respir Crit Care Med Source Type: research

Lifetime Exposure to Ambient Pollution and Lung Function in Children.
CONCLUSIONS: Estimates of long-term exposure to ambient pollution, including proximity to major roadway, PM2.5 and BC (a traffic-related PM2.5 constituent) were associated with lower lung function in this Boston-area cohort of children with relatively low pollution exposures. PMID: 26575800 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 17, 2015 Category: Respiratory Medicine Authors: Rice MB, Rifas-Shiman SL, Litonjua AA, Oken E, Gillman MW, Kloog I, Luttmann-Gibson H, Zanobetti A, Coull BA, Schwartz J, Koutrakis P, Mittleman MA, Gold DR Tags: Am J Respir Crit Care Med Source Type: research

The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21.
Conclusions These findings suggest that the chromosome 17q21 locus relates to episodes of acute airway obstruction common to both, transient wheeze and asthma. The previously identified 'asthma risk' alleles are the ones susceptible to environmental influences. Thereby this gene-by-environment interaction reveals two faces of 17q21: the same genotype constitutes genetic risk and allows for environmental protection thereby providing options for prospective prevention strategies. PMID: 26575599 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 17, 2015 Category: Respiratory Medicine Authors: Loss GJ, Depner M, Hose AJ, Genuneit J, Karvonen AM, Hyvärinen A, Roduit C, Kabesch M, Lauener R, Pfefferle PI, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ, PASTURE study group Tags: Am J Respir Crit Care Med Source Type: research

Right Versus Left Prong Nasal Cannula Flow Delivery and the Effects of Nasal Cycling on Inspired FIO2 in an Adult Anatomic Model.
CONCLUSIONS: Oxygen delivery by nasal cannula may be inefficient in the presence of the nasal cycle. Delivered nasal cannula oxygen concentrations decreased when bilateral nasal patency changed to unilateral nasal patency. Although statistically different, nasal cannula prong oxygen flow may not be clinically important across the full range of flows. PMID: 26577201 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 17, 2015 Category: Respiratory Medicine Authors: Marshall SG, Henry NR, Russian CJ Tags: Respir Care Source Type: research

Reduction of Endotracheal Tube Connector Dead Space Improves Ventilation: A Bench Test on a Model Lung Simulating an Extremely Low Birth Weight Neonate.
CONCLUSIONS: Both methods of instrumental dead-space reduction led to improvements in artificial lung ventilation. Negative effects on resistance and work of breathing appeared minimal. Further testing in vivo should be performed to confirm the lung model results and, if successful, translated into clinical practice. PMID: 26577200 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 17, 2015 Category: Respiratory Medicine Authors: Ivanov VA Tags: Respir Care Source Type: research

Randomized Controlled Trial of Humidified High-Flow Nasal Oxygen for Acute Respiratory Distress in the Emergency Department: The HOT-ER Study.
CONCLUSIONS: HFNC was not shown to reduce the need for mechanical ventilation in the emergency department for subjects with acute respiratory distress compared with standard O2, although it was safe and may reduce the need for escalation of oxygen therapy within the first 24 h of admission. PMID: 26577199 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 17, 2015 Category: Respiratory Medicine Authors: Jones PG, Kimona S, Doran O, Sawtell F, Wilsher M Tags: Respir Care Source Type: research

Effects of Nebulizer Position, Gas Flow, and CPAP on Aerosol Bronchodilator Delivery: An In Vitro Study.
CONCLUSIONS: Based on our in vitro study, without CPAP, a T-piece with a cap at one extremity maximizes albuterol delivery. During high-flow CPAP, the nebulizer should always be placed proximal to the patient, after the T-piece, using the highest CPAP clinically indicated. PMID: 26577198 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 17, 2015 Category: Respiratory Medicine Authors: Ball L, Sutherasan Y, Caratto V, Sanguineti E, Marsili M, Raimondo P, Ferretti M, Kacmarek RM, Pelosi P Tags: Respir Care Source Type: research

Cost effectiveness analysis of antiviral treatment in the management of seasonal influenza A: point-of-care rapid test versus clinical judgment.
This article is protected by copyright. All rights reserved. PMID: 26574910 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 17, 2015 Category: Respiratory Medicine Authors: Nshimyumukiza L, Douville X, Fournier D, Duplantie J, Daher R, Charlebois I, Longtin J, Papenburg J, Guay M, Boissinot M, Bergeron MG, Boudreau D, Gagné C, Rousseau F, Reinharz D Tags: Influenza Other Respir Viruses Source Type: research

Parents and adolescents preferences for asthma control: a best-worst scaling choice experiment using an orthogonal main effects design
The objective was to measure and compare the preferences of parents and adolescents with asthma with regard to asthma control parameters using best worst scaling (BWS). Methods: Fifty-two parents of children with asthma and 44 adolescents with asthma participated in a BWS study to quantify preferences regarding night-time symptoms, wheezing/chest tightening, changes in asthma medications, emergency visits and physical activity limitations. Conditional logit regression was used to determine each group’s utility for each level of each asthma control parameter. Results: Parents displayed the strongest positive preference fo...
Source: BMC Pulmonary Medicine - November 17, 2015 Category: Respiratory Medicine Authors: Wendy UngarAnahita HadioonzadehMehdi NajafzadehNicole TsaoSharon DellLarry Lynd Source Type: research

Agonistic 4-1BB antibody fails to reduce disease burden during acute respiratory syncytial virus (RSV) infection.
In this study, we examined the effect of agonistic 4-1BB antibody at the time of RSV infection in mice. We show that this antibody did not improve outcomes in the setting of RSV infection but rather, led to increased weight loss and a reduction in RSV specific CD8 T cells in the lung. This work suggests caution in the use of agonistic 4-1BB antibody in the setting of viral infections. PMID: 26597692 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - November 17, 2015 Category: Virology Authors: Norris MJ, Duan W, Cen Y, Moraes TJ Tags: Antiviral Res Source Type: research

Elastography for Predicting and Localizing Nodal Metastases during Endobronchial Ultrasound
Conclusions: Endobronchial elastography is feasible for lymph nodes when combined with CP-EBUS. Stiff area ratios are useful for predicting metastatic lymph nodes, which may be an efficient guide for TBNA.Respiration (Source: Respiration)
Source: Respiration - November 16, 2015 Category: Respiratory Medicine Source Type: research

[Newsdesk] Research brief
Findings from two studies suggest that statins, which have anti-inflammatory effects, might interfere with immune responses to influenza vaccination. Investigators of a retrospective cohort study that examined data for influenza vaccinations, statin prescriptions, and cases of medically attended acute respiratory illness over nine influenza seasons report that statin therapy was associated with reduced effectiveness of influenza vaccine against acute respiratory illness. Results from a cross-sectional observational study nested within a trial comparing the immunogenicity of adjuvanted and non-adjuvanted influenza vaccine i...
Source: The Lancet Infectious Diseases - November 16, 2015 Category: Infectious Diseases Authors: Jane Bradbury Tags: Newsdesk Source Type: research

Asthma under/misdiagnosis in primary care setting: an observational community-based study in Italy
Conclusions: The data suggest that there is still a large under/misdiagnosis of asthma in the Italian primary care setting, despite the spread of GINA guidelines nearly 20 years before this study. A validated tool like the ECRHS questionnaire has detected a considerable proportion of potentially asthmatic patients who should be addressed to lung function assessment to confirm the diagnosis. Further educational efforts directed to the GPs are needed to improve their diagnosis of asthma (SAM104964). (Source: BioMed Central)
Source: BioMed Central - November 16, 2015 Category: Journals (General) Authors: Maria MagnoniMarco CaminatiGianenrico SennaFabio ArpinelliAndrea RizziAnna DamaMichele SchiappoliGermano BettoncelliGaetano Caramori Source Type: research

Evaluation of experimental methods for nitric oxide release from cardiovascular implants; bypass grafts as an exemplar
Conclusions: The results of this study clearly demonstrate the relative difference between analysis techniques for accurate NO detection that can be applied to distinct experimental models associated with NO-eluting cardiovascular implants. (Source: Therapeutic Advances in Cardiovascular Disease)
Source: Therapeutic Advances in Cardiovascular Disease - November 16, 2015 Category: Cardiology Authors: Naghavi, N., Seifalian, A. M., Hamilton, G., de Mel, A. Tags: Original Research Source Type: research

Respiratory consequences of N95-type Mask usage in pregnant healthcare workers—a controlled clinical study
Background: Outbreaks of emerging infectious diseases have led to guidelines recommending the routine use of N95 respirators for healthcare workers, many of whom are women of childbearing age. The respiratory effects of prolonged respirator use on pregnant women are unclear although there has been no definite evidence of harm from past use. Methods: We conducted a two-phase controlled clinical study on healthy pregnant women between 27 to 32 weeks gestation. In phase I, energy expenditure corresponding to the workload of routine nursing tasks was determined. In phase II, pulmonary function of 20 subjects was measured whils...
Source: Epidemiologic Perspectives and Innovations - November 16, 2015 Category: Epidemiology Authors: Pearl TongAnita KaleKailyn NgAmelia LokeMahesh ChoolaniChin LimYiong ChanYap ChongPaul TambyahEu-Leong Yong Source Type: research

AT1 receptor blocker losartan protects against mechanical ventilation-induced diaphragmatic dysfunction
Mechanical ventilation is a life-saving intervention for patients in respiratory failure. Unfortunately, prolonged ventilator support results in diaphragmatic atrophy and contractile dysfunction leading to diaphragm weakness, which is predicted to contribute to problems in weaning patients from the ventilator. While it is established that ventilator-induced oxidative stress is required for the development of ventilator-induced diaphragm weakness, the signaling pathway(s) that trigger oxidant production remain unknown. However, recent evidence reveals that increased plasma levels of angiotensin II (ANG II) result in oxidati...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Kwon, O. S., Smuder, A. J., Wiggs, M. P., Hall, S. E., Sollanek, K. J., Morton, A. B., Talbert, E. E., Toklu, H. Z., Tumer, N., Powers, S. K. Tags: ARTICLES Source Type: research

Assessment of regional ventilation and deformation using 4D-CT imaging for healthy human lungs during tidal breathing
This study aims to assess regional ventilation, nonlinearity, and hysteresis of human lungs during dynamic breathing via image registration of four-dimensional computed tomography (4D-CT) scans. Six healthy adult humans were studied by spiral multidetector-row CT during controlled tidal breathing as well as during total lung capacity and functional residual capacity breath holds. Static images were utilized to contrast static vs. dynamic (deep vs. tidal) breathing. A rolling-seal piston system was employed to maintain consistent tidal breathing during 4D-CT spiral image acquisition, providing required between-breath consis...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Jahani, N., Choi, S., Choi, J., Iyer, K., Hoffman, E. A., Lin, C.-L. Tags: ARTICLES Source Type: research

Effects of serotonergic agents on respiratory recovery after cervical spinal injury
Unilateral cervical spinal cord hemisection (i.e., C2Hx) usually interrupts the bulbospinal respiratory pathways and results in respiratory impairment. It has been demonstrated that activation of the serotonin system can promote locomotor recovery after spinal cord injury. The present study was designed to investigate whether serotonergic activation can improve respiratory function during the chronic injury state. Bilateral diaphragm electromyogram and tidal volume were measured in anesthetized and spontaneously breathing adult rats at 8 wk post-C2Hx or C2 laminectomy. A bolus intravenous injection of a serotonin precursor...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Hsu (徐詩惠), S.-H., Lee (李昆澤), K.-Z. Tags: ARTICLES Source Type: research

Effect of age on long-term facilitation and chemosensitivity during NREM sleep
The reason for increased sleep-disordered breathing with a predominance of central apneas in the elderly is unknown. We speculate that ventilatory control instability may provide a link between aging and the onset of unstable breathing during sleep. We sought to investigate potential underlying mechanisms in healthy, elderly adults during sleep. We hypothesized that there is 1) a decline in respiratory plasticity or long-term facilitation (LTF) of ventilation and/or 2) increased ventilatory chemosensitivity in older adults during non-, this should be hyphenated, non-rapid rapid eye movement (NREM) sleep. Fourteen elderly a...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Chowdhuri, S., Pranathiageswaran, S., Franco-Elizondo, R., Jayakar, A., Hosni, A., Nair, A., Badr, M. S. Tags: ARTICLES Source Type: research

Hypoxia signaling during acute lung injury
Acute lung injury (ALI) is an inflammatory lung disease that manifests itself in patients as acute respiratory distress syndrome and thereby contributes significantly to the morbidity and mortality of patients experiencing critical illness. Even though it may seem counterintuitive, as the lungs are typically well-oxygenated organs, hypoxia signaling pathways have recently been implicated in the resolution of ALI. For example, functional studies suggest that transcriptional responses under the control of the hypoxia-inducible factor (HIF) are critical in optimizing alveolar epithelial carbohydrate metabolism, and thereby da...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Vohwinkel, C. U., Hoegl, S., Eltzschig, H. K. Tags: HIGHLIGHTED TOPIC Source Type: research

Cytochrome redox states and respiratory control in mouse and beef heart mitochondria at steady-state levels of hypoxia
Mitochondrial control of cellular redox states is a fundamental component of cell signaling in the coordination of core energy metabolism and homeostasis during normoxia and hypoxia. We investigated the relationship between cytochrome redox states and mitochondrial oxygen consumption at steady-state levels of hypoxia in mitochondria isolated from beef and mouse heart (BHImt, MHImt), comparing two species with different cardiac dynamics and local oxygen demands. A low-noise, rapid spectrophotometric system using visible light for the measurement of cytochrome redox states was combined with high-resolution respirometry. Mono...
Source: Journal of Applied Physiology - November 16, 2015 Category: Physiology Authors: Harrison, D. K., Fasching, M., Fontana-Ayoub, M., Gnaiger, E. Tags: HIGHLIGHTED TOPIC Source Type: research

A personalized paced-breathing intervention to increase heart rate variability among individuals with first-episode psychosis following stress exposure
Autonomic dysfunction following stress exposure is a hallmark of psychotic disorders (Castro et al., 2008) and may contribute to symptomatic exacerbations (Nuechterlein and Dawson, 1984). Consequently, paced breathing—an intervention shown to improve cardiac markers of arousal among individuals without psychosis (Nolan et al., 2005)—has been incorporated within several psychosocial interventions for psychosis (e.g., Bucci and Tarrier, 2010). However, due to reduced coupling between the cardiac and respiratory systems among individuals with psychosis (Bär et al., 2012) and the effects of antipsychotic medication on aut...
Source: Schizophrenia Research - November 16, 2015 Category: Psychiatry Authors: Nicholas J.K. Breitborde, David Dawley, Emily K. Bell, John R. Vanuk, John J.B. Allen, Richard D. Lane Tags: Letter to the Editor Source Type: research

Trends and New Evidence in the Management of Acute and Chronic Post-Thoracotomy Pain—An Overview of the Literature from 2005 to 2015
IN ADDITION TO being a major stressor, thoracotomies are associated with moderate-to-severe pain, impairment of respiratory function, protracted recovery, and the potential for the development of chronic pain. Of all surgical procedures, thoracotomies may create the greatest demand for postoperative analgesia.1 Even after less-invasive techniques, such as video- and robotic-assisted thoracoscopic surgery, postoperative pain is of considerable concern.2 Uncontrolled post-thoracotomy pain has important implications for a patient’s recovery and can add significant morbidity and increase healthcare costs. (Source: Journal of...
Source: Journal of Cardiothoracic and Vascular Anesthesia - November 16, 2015 Category: Anesthesiology Authors: David Rodriguez-Aldrete, Keith A. Candiotti, Rengarajan Janakiraman, Yiliam F. Rodriguez-Blanco Tags: Review ArticleGiovanni Landoni, MDSection Editors? > Source Type: research

A randomised controlled trial: can acupuncture reduce drug requirement during analgosedation with propofol and alfentanil for colonoscopy? A study protocol
Background: The number of colonoscopies tremendously increased in recent years and will further rise in the near future. Because of patients’ growing expectation on comfort during medical procedures, it is not surprising that the demand for sedation also expands. Propofol in combination with alfentanil is known to provide excellent analgosedation, however, its use is associated with respiratory and cardiovascular depression. Acupuncture could be a technique to reduce drug requirement while providing the same level of sedation and analgesia.Methods/designThe study will be performed as a single centre, randomised, placebo ...
Source: BMC Complementary and Alternative Medicine - November 16, 2015 Category: Complementary Medicine Authors: Susanne EberlNelson Monteiro de OliveraBenedikt PreckelKonrad StreitbergerPaul FockensMarkus Hollmann Source Type: research

Interleukin-10 as an indicator of chronic course of oral candidiasis in diabetics: an in vitro study
Abstract The importance of host defense against candidiasis and the role of cell-mediated immunity in host defense have been the subject of many studies. Increased expression of virulence factors in Candida isolates from diabetes mellitus (DM) patients with oropharyngeal candidiasis (OPC) has also been reported. To study the difference in T helper type 2 (Th2) and T helper type 1 (Th1) responses and neutrophil respiratory burst response, as a parameter of acute phase and adaptive immune responses, respectively, by using Candida isolates from lesions of oropharyngeal candidiasis (OPC) in DM patients compared to ora...
Source: International Journal of Diabetes in Developing Countries - November 16, 2015 Category: Endocrinology Source Type: research

Respiratory Laryngeal Coordination in Airflow Conservation and Reduction of Respiratory Effort of Phonation
This study evaluates the need of airflow conservation and the effect of glottal resistance on respiratory effort of phonation under different phonation conditions. (Source: Journal of Voice)
Source: Journal of Voice - November 16, 2015 Category: ENT & OMF Authors: Zhaoyan Zhang Source Type: research

Respiratory consequences of N95-type Mask usage in pregnant healthcare workers—a controlled clinical study
Conclusions Breathing through N95 mask materials have been shown to impede gaseous exchange and impose an additional workload on the metabolic system of pregnant healthcare workers, and this needs to be taken into consideration in guidelines for respirator use. The benefits of using N95 mask to prevent serious emerging infectious diseases should be weighed against potential respiratory consequences associated with extended N95 respirator usage. Trial Registration The study was registered at, identifier NCT00265926. (Source: Antimicrobial Resistance a...
Source: Antimicrobial Resistance and Infection Control - November 16, 2015 Category: Infectious Diseases Source Type: research

Clinical Reasoning: A 57-year-old woman who developed acute amnesia following fever and upper respiratory symptoms
(Source: Neurology)
Source: Neurology - November 16, 2015 Category: Neurology Authors: Finke, C., Pruss, H. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research

Evaluation of clinical, hematological, and biochemical changes following autologous blood transfusion in goats
In conclusion, slight changes in clinical, hematological, and biochemical parameters indicated that the autologous blood transfusion technique proposed in this study was safe and could be used in clinical practices in goats. (Source: Comparative Clinical Pathology)
Source: Comparative Clinical Pathology - November 16, 2015 Category: Pathology Source Type: research

Rhinovirus Detection in Symptomatic and Asymptomatic Children: Value of Host Transcriptome Analysis.
CONCLUSIONS: Symptomatic RV infection induced a robust and reproducible transcriptional signature, while identification of RV in asymptomatic children was not associated with significant systemic transcriptional immune responses. Transcriptional profiling represents a useful tool to discriminate between active infection and incidental virus detection. PMID: 26571305 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2015 Category: Respiratory Medicine Authors: Heinonen S, Jartti T, Garcia C, Oliva S, Smitherman C, Anguiano E, de Steenhuijsen Piters WA, Vuorinen T, Ruuskanen O, Dimo B, Suarez NM, Pascual V, Ramilo O, Mejias A Tags: Am J Respir Crit Care Med Source Type: research

Quantitative Dual Energy Computed Tomography Supports a Vascular Etiology of Smoking Induced Inflammatory Lung Disease.
CONCLUSIONS: These results demonstrate that sildenafil restores peripheral perfusion and reduces central arterial enlargement in normal SS subjects with little effect in NS subjects, highlighting DECT-PBV as a biomarker of reversible, endothelial dysfunction in smokers with CAE. PMID: 26569033 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 16, 2015 Category: Respiratory Medicine Authors: Iyer KS, Newell JD, Jin D, Fuld MK, Saha PK, Hansdottir S, Hoffman EA Tags: Am J Respir Crit Care Med Source Type: research

Modeling [ 18 F]-FDG lymphoid tissue kinetics to characterize nonhuman primate immune response to Middle East respiratory syndrome-coronavirus aerosol challenge
Conclusions [18F]-FDG-PET is able to detect subtle changes in host immune response to contain a subclinical virus infection. Full quantitative analysis is the preferred approach rather than semiquantitative analysis using standardized uptake value for detection of the immune response to the virus. (Source: EJNMMI Research)
Source: EJNMMI Research - November 16, 2015 Category: Radiology Source Type: research

Characteristics, disease burden and costs of COPD patients in the two years following initiation of long-acting bronchodilators in UK primary care
Conclusion: Cost and symptomatic burden of COPD was high among patients initiating maintenance treatment, including patients adherent with their initial treatment. General practitioner interactions were the primary driver of costs. Further, real world studies are required to address unmet needs and optimize treatment pathways to improve COPD symptom burden and outcomes. (Source: Respiratory Research)
Source: Respiratory Research - November 16, 2015 Category: Respiratory Medicine Authors: Yogesh PunekarSarah LandisKeele WurstHoa Le Source Type: research

PRO Case: That antibiotic prophylaxis should be used in children with repaired oesophageal atresia and trachea-oesophageal fistula.
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - November 16, 2015 Category: Respiratory Medicine Authors: Peter Merkus Source Type: research

Respiratory symptoms and cross-shift lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal: a cross-sectional study
Conclusions This study is the first to investigate the respiratory health of Nepalese cotton workers. The measured association between inhalable dust exposure and reporting of respiratory symptoms and across-shift decrement in FEV1 and FVC indicates that improved dust control measures should be instituted, particularly in the recycling and carpet sectors. The possible role of other biologically active agents of cotton dust beyond endotoxin should be further explored. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - November 16, 2015 Category: Occupational Health Authors: Paudyal, P., Semple, S., Gairhe, S., Steiner, M. F. C., Niven, R., Ayres, J. G. Tags: Workplace Source Type: research

Analytical Sensitivity Comparison between Singleplex Real-Time PCR and a Multiplex PCR Platform for Detecting Respiratory Viruses
by Jayme Parker, Nisha Fowler, Mary Louise Walmsley, Terri Schmidt, Jason Scharrer, James Kowaleski, Teresa Grimes, Shanann Hoyos, Jack Chen Multiplex PCR methods are attractive to clinical laboratories wanting to broaden their detection of respiratory viral pathogens in clinical specimens. However, multiplexed assays must be well optimized to retain or improve upon the analytic sensitivity of their singleplex counterparts. In this experiment, the lower limit of detection (LOD) of singleplex real-time PCR assays targeting respiratory viruses is compared to an equivalent panel on a multiplex PCR platform, the GenMark eSens...
Source: PLoS One - November 16, 2015 Category: Biomedical Science Authors: Jayme Parker et al. Source Type: research