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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Evaluation of Lung Cancer by Estimating Ferritin in Exhaled Breath Condensate
Conclusion The estimated ferritin level in EBC can serve as a non invasive and inexpensive marker for screening of lung cancer. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Hypothyroidism in MDR-TB treatment – Rare occurrence but a major concern
Conclusions Occurrence of hypothyroidism is rare in MDRTB treatment. But symptomatic hypothyroidism is a major factor influencing the patient compliance towards the treatment regimen. As the drugs in regimen are effective in disease treatment, the major hindrance in achieving good cure-rate is to prevent defaulters. Identifying hypothyroidism early helps to prevent default. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Rare initial presentation of all as pleural effusion
Publication date: Available online 7 April 2015 Source:Egyptian Journal of Chest Diseases and Tuberculosis Author(s): Ashwini Kumar Mishra , Santosh Kumar , Suresh Babu , S.K. Verma , Rajiv Garg , R.A.S. Kushwaha Leukemias rarely present as pleural effusion as the first manifestation of the disease process. Most commonly this complication is seen in solid tumors such as the lung, lymphomas, carcinomas of the breast and gastrointestinal tract. A case of 40year old male is hereby highlighted who presented with a massive pleural effusion as the initial presentation of his disease process (ALL) which is a rare phenomenon to ...
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Total serum IgE level in COPD patients
Conclusions There was a high prevalence of elevated serum T-IgE in patients with COPD but without obvious atopy. Serum T-IgE levels were found to be associated with symptoms such as dyspnea and impairment of lung function. Recurrent exacerbation of COPD is believed to accelerate disease progression and impairment of pulmonary function. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

The cost of acute respiratory infections in Northern India: a multi-site study
Background: Despite the high mortality and morbidity resulting from acute respiratory infections (ARI) globally, there are few data from low-income countries on costs of ARI to inform public health policy decisions We conducted a prospective survey to assess costs of ARI episodes in selected primary, secondary, and tertiary healthcare facilities in north India where no respiratory pathogen vaccine is routinely recommended. Methods: Face-to-face interviews were conducted among a purposive sample of patients with ARI from healthcare facilities. Data were collected on out-of-pocket costs of hospitalization, medical consultati...
Source: BMC Public Health - April 7, 2015 Category: Consumer Health News Authors: Samuel PeasahDebjani PurakayasthaParvaiz KoulFatima DawoodSiddhartha SahaRitvik AmarchandShobha BroorVaibhab RastogiRomana AssadKaisar KaulMarc-Alain WiddowsonRenu LalAnand Krishnan Source Type: research

Nintedanib in non-small cell lung cancer: from preclinical to approval.
Abstract Angiogenesis is a driving force of a tumor's development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF...
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Caglevic C, Grassi M, Raez L, Listi A, Giallombardo M, Bustamante E, Gil-Bazo I, Rolfo C Tags: Ther Adv Respir Dis Source Type: research

Bronchoconstriction in Response to Deep Inhalation During Spirometry Testing.
PMID: 25852168 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Haynes JM Tags: Respir Care Source Type: research

Use of Accelerometry to Monitor Physical Activity in Critically Ill Subjects: A Systematic Review.
Abstract Medical management of critically ill patients often incorporates prolonged bed rest, which, in combination with the underlying illness, results in global muscle weakness and atrophy. Recent evidence has demonstrated improvements in clinical and functional outcomes when exercise and physical activity are incorporated early in the management of ICU patients. Accurate monitoring of ICU patients' physical activity is essential for proper prescription and escalation of activity levels. Accelerometry is a technique used to measure physical activity and has been validated in several ambulatory populations. Howeve...
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Verceles AC, Hager ER Tags: Respir Care Source Type: research

Effect of Weight Loss on Postural Changes in Pulmonary Function in Obese Subjects: A Longitudinal Study.
CONCLUSIONS: Although postural change in FRC is absent when the morbidly obese adopt a supine position, supine reduction in FRC can be recovered following gastroplasty-induced weight loss, despite residual mild to moderate obesity. This also shows that mild to moderate obesity may affect supine FRC more than morbid obesity. (ClinicalTrials.gov registration NCT02207192.). PMID: 25852166 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Sebbane M, Kamel ME, Millot A, Jung B, Lefebvre S, Rubenovitch J, Mercier G, Eledjam JJ, Jaber S, Hayot M Tags: Respir Care Source Type: research

Pseudomonas endophytica sp. nov., isolated from stem tissue of Solanum tuberosum L. in Spain.
Abstract A bacterial strain named BSTT44T was isolated in the course of a study of endophytic bacteria occurring in stems and roots of potato growing in a soil from Salamanca, Spain. The 16S rRNA gene sequence had 99.7% identity with respect to the closest relative Pseudomonas psychrophila E-3T, and the following closest related species were Pseudomonas fragi with 99.6 % similarity, Pseudomonas deceptionensis with 99.2 % and Pseudomonas lundensis with 99.0% similarity, for which BSTT44T was classified within genus Pseudomonas. The analysis of housekeeping genes rpoB, rpoD and gyrB confirmed its phylogenetic affilia...
Source: International Journal of Systematic and Evolutionary Microbiology - April 7, 2015 Category: Microbiology Authors: Ramírez-Bahena MH, Cuesta MJ, Tejedor C, Igual JM, Fernández-Pascual M, Peix A Tags: Int J Syst Evol Microbiol Source Type: research

Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders).
Abstract Burkholderia mallei is a Gram-negative bacillus that causes a pneumonic disease known as glanders in equids and humans and a lymphatic infection known as farcy, primarily in equids. With the potential to infect humans by the respiratory route, aerosol exposure can result in severe, occasionally fatal, pneumonia. Today, glanders infections in humans are rare, likely due to less frequent contact with infected equids than in the past. Acutely ill humans often have nonspecific clinical signs and in order to diagnose cases, especially in scenarios of multiple cases in an unexpected setting, rapid diagnostics fo...
Source: Journal of Medical Microbiology - April 7, 2015 Category: Microbiology Authors: Yingst SL, Facemire P, Chuvala L, Norwood D, Wolcott M, Huzella L Tags: J Med Microbiol Source Type: research

Mixed-Effects Model of Epithelial-Mesenchymal Transition Reveals Rewiring of Signaling Networks.
Abstract The type II Epithelial-Mesenchymal Transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on signaling networks. Here, we use mixed effects modeling to develop a computational model of phospho-protein signaling data that compares human small airway epithelial cells (hSAECs) with their EMT-transformed counterparts across a series of perturbations with 8 ligands and 5 inhibitors, revealing...
Source: Cellular Signalling - April 7, 2015 Category: Cytology Authors: Desai P, Yang J, Tian B, Sun H, Kalita M, Ju H, Paulucci-Holthauzen A, Zhao Y, Brasier AR, Sadygov RG Tags: Cell Signal Source Type: research

Regional lung tissue changes with mechanical ventilation and fluid load
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Mold allergens in respiratory allergy: from structure to therapy.
Authors: Twaroch TE, Curin M, Valenta R, Swoboda I Abstract Allergic reactions to fungi were described 300 years ago, but the importance of allergy to fungi has been underestimated for a long time. Allergens from fungi mainly cause respiratory and skin symptoms in sensitized patients. In this review, we will focus on fungi and fungal allergens involved in respiratory forms of allergy, such as allergic rhinitis and asthma. Fungi can act as indoor and outdoor respiratory allergen sources, and depending on climate conditions, the rates of sensitization in individuals attending allergy clinics range from 5% to 20%. Due...
Source: Allergy, Asthma and Immunology Research - April 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Pulmonary edema measured by MRI correlates with late-phase response to allergen challenge
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Age influences inflammatory responses, hemodynamics, and cardiac proteasome activation during acute lung injury
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Neuron-derived orphan receptor 1 promoted human pulmonary artery smooth muscle cells proliferation
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Preemptive scalp infiltration with 0.5 % ropivacaine and 1 % lidocaine reduces postoperative pain after craniotomy
Conclusions Preemptive scalp infiltration with 0.5 % ropivacaine and 1 % lidocaine provides effective postoperative analgesia after craniotomy. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 6, 2015 Category: Neurosurgery Source Type: research

PCA-derived respiratory motion surrogates from X-ray angiograms for percutaneous coronary interventions
Conclusions we developed and evaluated a method in extraction of respiratory motion surrogate from interventional X-ray images that is easy to implement and runs in real time and thus allows extracting respiratory motion surrogates during interventions. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - April 6, 2015 Category: Intensive Care Source Type: research

Physical functional capacity in idiopathic pulmonary fibrosis: performance characteristics of the continuous-scale physical function performance test
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Low-level Circulation of Enterovirus D68–Associated Acute Respiratory Infections, Germany, 2014
J. Reiche et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - April 6, 2015 Category: Infectious Diseases Source Type: research

Comprehensive evaluation of poly(I:C) induced inflammatory response in an airway epithelial model
This study provides first steps toward a well‐characterized model with defined functional methods for understanding dsRNA stimulated inflammatory responses in a physiologically relevant manner. 12334 In this study we explore the mechanistic responses of a primary human bronchial epithelial model, that recapitulates in vivo airway physiology, to poly(I:C), a synthetic analog of viral dsRNA. We demonstrate that our model recapitulates innate immune responses to poly(I:C) stimulation by establishing metrics to evaluate baseline functions, such as mucus production and epithelial cell alterations, as well as gene and cytokin...
Source: Physiological Reports - April 6, 2015 Category: Physiology Authors: Amanda R. Lever, Hyoungshin Park, Thomas J. Mulhern, George R. Jackson, James C. Comolli, Jeffrey T. Borenstein, Patrick J. Hayden, Rachelle Prantil‐Baun Tags: Original Research Source Type: research

The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques
Abstract There is substantial interest in studying lung function in infants, to better understand the early life origins of chronic lung diseases such as asthma. Multiple breath washout (MBW) is a technique for measuring lung function that has been adapted for use in infants. Respiratory sighs occur frequently in young infants during natural sleep, and in accordance with current MBW guidelines, result in exclusion of data from a substantial proportion of testing cycles. We assessed how sighs during MBW influenced the measurements obtained using data from 767 tests conducted on 246 infants (50% male; mean age 43 days) as p...
Source: Physiological Reports - April 6, 2015 Category: Physiology Authors: Damjan Vukcevic, John B. Carlin, Louise King, Graham L. Hall, Anne‐Louise Ponsonby, Peter D. Sly, Peter Vuillermin, Sarath Ranganathan, Tags: Original Research Source Type: research

Leaky intestine and impaired microbiome in an amyotrophic lateral sclerosis mouse model
We examined the gut of an ALS mouse model, G93A, which expresses mutant superoxide dismutase (SOD1G93A), and discovered a damaged tight junction structure and increased permeability with a significant reduction in the expression levels of tight junction protein ZO‐1 and the adherens junction protein E‐cadherin. Furthermore, our data demonstrated increased numbers of abnormal Paneth cells in the intestine of G93A mice. Paneth cells are specialized intestinal epithelial cells that can sense microbes and secrete antimicrobial peptides, thus playing key roles in host innate immune responses and shaping the gut microbiome. ...
Source: Physiological Reports - April 6, 2015 Category: Physiology Authors: Shaoping Wu, Jianxun Yi, Yong‐guo Zhang, Jingsong Zhou, Jun Sun Tags: Original Research Source Type: research

Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics
Publication date: Available online 25 March 2015 Source:Nanomedicine: Nanotechnology, Biology and Medicine Author(s): Xueting Li , Min Xue , Otto G. Raabe , Holly L. Aaron , Ellen A. Eisen , James E. Evans , Fred A. Hayes , Sumire Inaga , Abderrahmane Tagmout , Minoru Takeuchi , Chris Vulpe , Jeffrey I. Zink , Subhash H. Risbud , Kent E. Pinkerton A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, in...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - April 6, 2015 Category: Nanotechnology Source Type: research

Clinical Reasoning: A 57-year-old woman who developed acute amnesia following fever and upper respiratory symptoms
A 57-year-old woman with a history of depression and hyperlipidemia presented with 2 days of confusion and memory loss. Four days prior to presentation, she developed fevers, myalgias, and rhinorrhea. On the day prior to presentation, the patient began having memory difficulties and was noted by her husband to have completely forgotten many events and details of the previous days. She presented to an outside hospital where a comprehensive neurologic examination disclosed a nonfluent expressive aphasia but was otherwise unremarkable. Basic laboratory tests including electrolytes, complete blood count, and liver function tes...
Source: Neurology - April 6, 2015 Category: Neurology Authors: McCray, B. A., Forst, D., Jindal, J., Henderson, G. V. Tags: Encephalitis, Viral infections, Critical care RESIDENT AND FELLOW SECTION Source Type: research

Impaired Muscle Mitochondrial Biogenesis and Myogenesis in Spinal Muscular Atrophy
ImportanceThe important depletion of mitochondrial DNA (mtDNA) and the general depression of mitochondrial respiratory chain complex levels (including complex II) have been confirmed, implying an increasing paucity of mitochondria in the muscle from patients with types I, II, and III spinal muscular atrophy (SMA-I, -II, and -III, respectively).ObjectiveTo investigate mitochondrial dysfunction in a large series of muscle biopsy samples from patients with SMA.Design, Setting, and ParticipantsWe studied quadriceps muscle samples from 24 patients with genetically documented SMA and paraspinal muscle samples from 3 patients wit...
Source: JAMA Neurology - April 6, 2015 Category: Neurology Source Type: research

A pulmonary tumor‐like mass resolving with antibiotics
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 6, 2015 Category: Respiratory Medicine Authors: Alessandro Marchioni, Maria C. Mengoli, Eleonora Casalini, Giulio Rossi Tags: Letter to the Editor Source Type: research

Early vs late tracheostomy in critically ill patients: a systematic review and meta‐analysis
ConclusionsOur meta‐analysis suggested that ET might be able to reduce the duration of sedation but did not significantly alter the mortality, incidence of VAP, duration of MV and length of ICU stay. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 6, 2015 Category: Respiratory Medicine Authors: Liang Meng, Chunmei Wang, Jianxin Li, Jian Zhang Tags: Review Article Source Type: research

Aetiology and risk factors of community‐acquired pneumonia in hospitalized patients in Norway
ConclusionOur results indicate that S. pneumoniae is the most common bacterial cause of pneumonia in hospitalized patients, and the prevalence of Legionella pneumonia is probably higher in Norway than recognized previously. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 6, 2015 Category: Respiratory Medicine Authors: Wenche Røysted, Øystein Simonsen, Andrew Jenkins, Marjut Sarjomaa, Martin Veel Svendsen, Eivind Ragnhildstveit, Yngvar Tveten, Anita Kanestrøm, Halfrid Waage, Jetmund Ringstad Tags: Original Article Source Type: research

Prevalence of hypoxemia in under-five children with pneumonia in an emergency pediatrics hospital in Sudan
Conclusions: The prevalence of hypoxemia was 42.7% among the studied population. There was a significant association between the hypoxemia and small age group and very severe pneumonia. In limited resource settings pulse oximeter can be used to correctly identify hypoxemia in under-five children particularly among those diagnosed clinically as very severe pneumonia. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - April 6, 2015 Category: Intensive Care Authors: Elmuntasir Taha SalahSamah Hamadnalla AlgasimAlamin Saeed MhamoudNazik Elmalaika Obaid Seid Ahmed Husian Source Type: research

Function of respiratory system evaluated using selected spirometry parameters in persons occupationally exposed to lead without evident health problems
Conclusion. Persons occupationally exposed to lead with elevated blood lead concentration and blood zinc protoporphyrin concentration manifested the impaired function of respiratory system, evaluated using parameters of spirometry. (Source: Environmental Toxicology and Pharmacology)
Source: Environmental Toxicology and Pharmacology - April 6, 2015 Category: Environmental Health Source Type: research

Utility of shock index calculation in hemorrhagic trauma
We read with great interest the article by Shwetha Edla et al. comparing heart rate variability metrics (HRV) vs routine vital signs as diagnostic tests, to improve trauma patient management focusing on the identification of trauma patients with major hemorrhage [1]. They conducted a multivariate analysis, using routine vital signs (heart rate, respiratory rate, systolic blood pressure , and pulse pressure ) as the comparator to test the hypothesis that HRV metrics can improve the identification of patients with major hemorrhage. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 6, 2015 Category: Emergency Medicine Authors: Marilyn Franchin, Daniel Jost, Hugues Lefort, Stephane Travers, Jean-Pierre Tourtier Tags: Case Report Source Type: research

Extremely obese patients treated with veno-venous extracorporeal membrane oxygenation (vv ECMO) – an intensivists´ challenge
We report on two surgical patients (BMI > 70 kg/m2) with postoperative acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The first patient developed severe pneumonia with ARDS on the fourth day postsurgical intervention and veno-venous (vv) ECMO was performed. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 6, 2015 Category: Emergency Medicine Authors: Christopher Ull, Dirk Buchwald, Justus Strauch, Thomas Armin Schildhauer, Justyna Swol Source Type: research

Plastic bronchitis arising from solitary influenza B infection: a report of two cases in children
This study is a retrospective case series of two children who presented to our institution in acute respiratory distress. Emergency rigid bronchoscopy was performed with extraction of casts from the mainstem bronchus in both patients. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - April 6, 2015 Category: ENT & OMF Authors: Stephen J. Nogan, Nathan D. Cass, Gregory J. Wiet, James M. Ruda Tags: Case Report Source Type: research

Natural T Cell Mediated Protection Against Seasonal and Pandemic Influenza: Results of the Flu Watch Cohort Study.
CONCLUSIONS: Naturally occurring cross-protective T cell immunity protects against symptomatic PCR-confirmed disease in those with evidence of infection and helps to explain why many infections do not cause symptoms. Vaccines stimulating T cells may provide important cross-protective immunity. PMID: 25844934 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 6, 2015 Category: Respiratory Medicine Authors: Hayward AC, Wang L, Goonetilleke N, Fragaszy EB, Bermingham A, Copas A, Dukes O, Millett ER, Nazareth I, Nguyen-Van-Tam JS, Watson JM, Zambon M, Johnson AM, McMichael AJ, Flu Watch Group Tags: Am J Respir Crit Care Med Source Type: research

History of Mechanical Ventilation: From Vesalius to Ventilator-Induced Lung Injury.
Abstract Mechanical ventilation is a life-sustaining therapy for the treatment of patients with acute respiratory failure. It is a very common modality in intensive care units (ICU), and indeed the advent of its use heralded the dawn of modern ICUs. Interest in mechanical ventilation has increased markedly from both a research and a clinical perspective over the past 15 years since the publication of a milestone article in the New England Journal of Medicine by the ARDSNet investigators which highlighted the importance of a lung protective ventilation strategy1. PMID: 25844759 [PubMed - as supplied by publisher] ...
Source: American Journal of Respiratory and Critical Care Medicine - April 6, 2015 Category: Respiratory Medicine Authors: Slutsky AS Tags: Am J Respir Crit Care Med Source Type: research