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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Obesity hypoventilation syndrome: current theories of pathogenesis
Purpose of review: To summarize recent primary publications and discuss the impact these finding have on current understanding on the development of hypoventilation in obesity hypoventilation syndrome (OHS), also known as Pickwickian syndrome. Recent findings: As a result of the significant morbidity and mortality associated with OHS, evidence is building for pre-OHS intermediate states that can be identified earlier and treated sooner, with the goal of modifying disease course. Findings of alterations in respiratory mechanics with obesity remain unchanged; however, elevated metabolism and CO2 production may be instrumenta...
Source: Current Opinion in Pulmonary Medicine - September 28, 2015 Category: Respiratory Medicine Tags: SLEEP AND RESPIRATORY NEUROBIOLOGY: Edited by Lee K. Brown and Adrian Williams Source Type: research

Autoimmune rheumatic disease and sleep: a review
Purpose of review: Sleep has an important role to play in the human immune system and it is critical in the restoration and maintenance of homeostasis. Sleep deprivation and disorders may have a profound impact on health, well being and the ability to resist infection. Autoimmune rheumatic diseases are multisystem disorders that involve complicated hormonal and immunological pathophysiology. Previous studies have suggested that sleep deprivation may lead to immunological disturbance in experimental mouse models. Recent findings: Sleep disorders may trigger immune system abnormalities inducing autoantibody production, possi...
Source: Current Opinion in Pulmonary Medicine - September 28, 2015 Category: Respiratory Medicine Tags: SLEEP AND RESPIRATORY NEUROBIOLOGY: Edited by Lee K. Brown and Adrian Williams Source Type: research

The value of mindfulness meditation in the treatment of insomnia
This article reviews mindfulness meditation as an additional therapy for insomnia. Recent findings: Both mindfulness-based stress reduction (MBSR) and mindfulness-based therapy for insomnia (MBTI) have been studied in the treatment of insomnia. Randomized controlled studies of MBSR and MBTI have shown overall reduction in sleep latency and total wake time and increase in total sleep time after mindfulness therapy using both patient reported outcome and quantitative measures of sleep. Mindfulness techniques have been shown to be well accepted by patients with long-lasting effects. A three-arm randomized study with MBSR, MBT...
Source: Current Opinion in Pulmonary Medicine - September 28, 2015 Category: Respiratory Medicine Tags: SLEEP AND RESPIRATORY NEUROBIOLOGY: Edited by Lee K. Brown and Adrian Williams Source Type: research

Contribution of air pollution to COPD and small airway dysfunction
Abstract Although in many Western countries levels of ambient air pollution have been improving with the setting of upper limits and better urban planning, air pollution in developing countries and particularly those with rapid industrialization has become a major global problem. Together with increased motor vehicle ownership and traffic congestion, there is a growing issue with airborne particles of respirable size. These particles are thought responsible for respiratory and cardiovascular effects and have also been implicated in cancer pathogenesis. The pathologic effects in the lung are mediated via inflammatory pathwa...
Source: Respirology - September 28, 2015 Category: Respiratory Medicine Authors: Norbert Berend Tags: Invited Review Series: Unravelling the Many Faces of COPD to Optimize Its Care and Outcomes Source Type: research

Identifying and Describing the Impact of Cyclone, Storm and Flood Related Disasters on Treatment Management, Care and Exacerbations of Non-communicable Diseases and the Implications for Public Health
Conclusion Cyclone, flood and storm related disasters impact on treatment management and overall care for people with NCDs. This results in an increased risk of exacerbation of illness or even death. The interruption may be caused by a range of factors, such as damaged transport routes, reduced health services, loss of power and evacuations. The health impact varies according to the NCD. For people with chronic respiratory diseases, a disaster increases the risk of acute exacerbation. Meanwhile, for people with cancer, cardiovascular diseases and diabetes there is an increased risk of their illness exacerbating, which can ...
Source: PLOS Currents Disasters - September 28, 2015 Category: Global & Universal Authors: jc164421 Source Type: research

Single breath counting for the evaluation of pediatric respiratory function: derivation of a “normogram”
We present an equation for predicting normal results (a “normogram”). (Source: Internal and Emergency Medicine)
Source: Internal and Emergency Medicine - September 28, 2015 Category: Emergency Medicine Source Type: research

Ventilation Effects on Respiratory Outcomes in Low-Birth-Weight Infants
This cohort study of extremely low-birth-weight infants reports that longer mechanical ventilation accounts for the increased risk of chronic respiratory morbidity associated with mechanical ventilation reinitiation. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - September 28, 2015 Category: Pediatrics Source Type: research

Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition
Conclusion Our results demonstrated that YPF-G could ameliorate bleomycin-induced PF by reducing HMGB1 activation and reversing EMT. (Source: Inflammation Research)
Source: Inflammation Research - September 28, 2015 Category: Research Source Type: research

Reply to “Serum high-sensitivity C-reactive protein in patients with obstructive sleep apnea with special reference to metabolic syndrome” by Kawada (Letter to the Editor)
(Source: Sleep and Breathing)
Source: Sleep and Breathing - September 28, 2015 Category: Respiratory Medicine Source Type: research

Elucidating COPD pathogenesis by large-scale genetic analyses
Publication date: Available online 27 September 2015 Source:The Lancet Respiratory Medicine Author(s): Guy G Brusselle, Ken R Bracke (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - September 28, 2015 Category: Respiratory Medicine Source Type: research

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank
Publication date: Available online 27 September 2015 Source:The Lancet Respiratory Medicine Author(s): Louise V Wain, Nick Shrine, Suzanne Miller, Victoria E Jackson, Ioanna Ntalla, María Soler Artigas, Charlotte K Billington, Abdul Kader Kheirallah, Richard Allen, James P Cook, Kelly Probert, Ma'en Obeidat, Yohan Bossé, Ke Hao, Dirkje S Postma, Peter D Paré, Adaikalavan Ramasamy, Reedik Mägi, Evelin Mihailov, Eva Reinmaa, Erik Melén, Jared O'Connell, Eleni Frangou, Olivier Delaneau, Colin Freeman, Desislava Petkova, Mark McCarthy, Ian Sayers, Panos Deloukas, Richard Hubbard, Ian Pavor...
Source: The Lancet Respiratory Medicine - September 28, 2015 Category: Respiratory Medicine Source Type: research

Differences between nurse- and physician-assessed ICU characteristics using a standardized survey
Conclusions Despite a standardized survey, we found substantial disagreement on ICU characteristics when assessed by the nurse manager or physician director. This study raises questions about the use of surveys to examine ICU organizational characteristics and suggests that differences in nurse managers’ and medical directors’ assessments could be helpful in guiding future ICU quality improvement projects. (Source: International Journal for Quality in Health Care)
Source: International Journal for Quality in Health Care - September 28, 2015 Category: Global & Universal Authors: Costa, D. K., Kuza, C. C., Kahn, J. M. Tags: Papers Source Type: research

Mechanical Ventilation and Bronchopulmonary Dysplasia
Mechanical ventilation is an important potentially modifiable risk factor for the development of bronchopulmonary dysplasia. Effective use of noninvasive respiratory support reduces the risk of lung injury. Lung volume recruitment and avoidance of excessive tidal volume are key elements of lung-protective ventilation strategies. Avoidance of oxidative stress, less invasive methods of surfactant administration, and high-frequency ventilation are also important factors in lung injury prevention. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - September 28, 2015 Category: Perinatology & Neonatology Authors: Martin Keszler, Guilherme Sant’Anna Source Type: research

Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity
This article reviews aspects of host-pathogen interactions and immune responses that are altered by preterm birth and that impact chronic respiratory morbidity in these children. (Source: Clinics in Perinatology)
Source: Clinics in Perinatology - September 28, 2015 Category: Perinatology & Neonatology Authors: Gloria S. Pryhuber Source Type: research

Successful management of severe unilateral re-expansion pulmonary edema after mitral valve repair with mini-thoracotomy using extracorporeal membrane oxygenation
Abstract A 60-year-old man received mitral valve repair via right mini-thoracotomy, which was followed by unilateral re-expansion pulmonary edema on the right side and severe hemoptysis just after the surgery. Despite differential lung ventilation with unilateral high positive end expiratory pressure was initiated for the affected right lung, respiratory function did not improved and hemodynamics was collapsed in the next day. Veno-venous extracorporeal membrane oxygenation was initiated by cannulation of the right jugular and the left femoral vein. After pulmonary function recovered gradually, veno-venous extraco...
Source: General Thoracic and Cardiovascular Surgery - September 28, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Chronic Obstructive Pulmonary Disease and the Risk of Stroke: the Rotterdam Study.
CONCLUSION: Our cohort study demonstrated a higher risk of both ischemic and hemorrhagic stroke in subjects with COPD, and revealed the importance of smoking as a shared risk factor. PMID: 26414484 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 28, 2015 Category: Respiratory Medicine Authors: Portegies ML, Lahousse L, Joos GF, Hofman A, Koudstaal PJ, Stricker BH, Brusselle GG, Ikram MA Tags: Am J Respir Crit Care Med Source Type: research

Blood Pressure Response to Losartan and CPAP in Hypertension and Obstructive Sleep Apnea.
CONCLUSIONS: Losartan reduced BP in OSA, but the reductions were less than in no-OSA. Add-on CPAP therapy resulted in no significant changes in 24-h BP measures except in patients using CPAP efficiently. Clinical trial registration available at, ID NCT00701428. PMID: 26414380 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 28, 2015 Category: Respiratory Medicine Authors: Thunström E, Manhem K, Rosengren A, Peker Y Tags: Am J Respir Crit Care Med Source Type: research

Assessment of Global Incidence and Mortality of Hospital-treated Sepsis - Current Estimates and Limitations.
CONCLUSIONS: Population-level epidemiological data for sepsis are scarce, and non-existent for low- and middle-income-countries. Our analyses underline the urgent need to implement global strategies to measure sepsis morbidity and mortality - particularly in low- and middle-income-countries. PMID: 26414292 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 28, 2015 Category: Respiratory Medicine Authors: Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K, International Forum of Acute Care Trialists Tags: Am J Respir Crit Care Med Source Type: research

Diversity of Interstitial Lung Fibroblasts is Regulated by PDGFRα Kinase Activity.
Abstract Epithelial-mesenchymal cell interactions and factors that control normal lung development are key players in lung injury, repair and fibrosis. A number of studies have investigated the roles and sources of epithelial progenitors during lung regeneration; such information is, however, limited in lung fibroblasts. Thus, understanding the origin, phenotype and roles of fibroblast progenitors in lung development, repair and regeneration helps address these limitations. Using a combination of PDGFRα-GFP reporter mice, micro array, real time PCR, flow cytometry and immunofluorescence, we characterized two disti...
Source: Am J Respir Cell Mol... - September 28, 2015 Category: Respiratory Medicine Authors: Green J, Endale M, Auer H, Perl AT Tags: Am J Respir Cell Mol Biol Source Type: research

IL-13 Inhibits Multicilin Expression and Ciliogenesis via JAK/STAT Independently of Notch Cleavage.
Abstract Loss of ciliated cells and increases in goblet cells are seen in respiratory diseases such as asthma. These changes result in part from reduced differentiation of basal progenitor cells to ciliated cells during injury and repair. The Th2 cytokine, IL-13, has been shown to inhibit ciliated cell differentiation but the mechanism is not clearly understood. We recently showed that Notch signaling inhibits ciliated cell differentiation in submerged culture by repressing multicilin and FOXJ1 expression, genes required for ciliogenesis. Using a novel method to study ciliated cell differentiation we investigated t...
Source: Am J Respir Cell Mol... - September 28, 2015 Category: Respiratory Medicine Authors: Gerovac BJ, Fregien NL Tags: Am J Respir Cell Mol Biol Source Type: research

SMAD Signaling in the Airways of Healthy Versus Asthmatic Rhesus Macaques Highlights a Relationship Between Inflammation and BMPs.
In this study, a rhesus macaque (Macaca mulatta) model of allergic airway disease was used to investigate BMP signaling throughout the airways in health, disease and regeneration. Stereologic quantification of immunofluorescent images was used to determine the expression of BMPRIa and pSMAD 1/5/8 in the airway epithelium. A pSMAD 1/5/8 expression gradient was found along the airways of healthy juvenile rhesus macaques (n=3, p<0.005). Membrane-localized BMPRIa expression was also present in the epithelium of the healthy animals. Following exposure to house dust mite allergen and ozone, significant downregulation of nucle...
Source: Am J Respir Cell Mol... - September 28, 2015 Category: Respiratory Medicine Authors: Lynn TM, Molloy EL, Masterson JC, Glynn SF, Costello RW, Avdalovic MV, Schelegle ES, Miller LA, Hyde DM, O'Dea S Tags: Am J Respir Cell Mol Biol Source Type: research

Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension.
CONCLUSIONS: Our data demonstrate that the hypoxic-adenosine axis is up-regulated in Group III PH and that subsequent succinate accumulation may play a part in the development of Group III PH. PMID: 26414702 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - September 28, 2015 Category: Respiratory Medicine Authors: Garcia-Morales LJ, Chen NY, Weng T, Luo F, Davies J, Philip K, Volcik KA, Melicoff E, Amione-Guerra J, Bunge RR, Bruckner BA, Loebe M, Eltzschig HK, Pandit LM, Blackburn MR, Karmouty-Quintana H Tags: Am J Respir Cell Mol Biol Source Type: research

Atopic Dermatitis and Respiratory Allergy: What is the Link
Abstract Understanding the aetiology and progression of atopic dermatitis and respiratory allergy may elucidate early preventative and management strategies aimed towards reducing the global burden of asthma and allergic disease. In this article, we review the current opinion concerning the link between atopic dermatitis and the subsequent progression of respiratory allergies during childhood and into early adolescence. Advances in machine learning and statistical methodology have facilitated the discovery of more refined definitions of phenotypes for identifying biomarkers. Understanding the role of atopic dermat...
Source: Current Dermatology Reports - September 28, 2015 Category: Dermatology Source Type: research

Randomized clinical trial of the efficacy and safety of insulin glargine vs. NPH insulin as basal insulin for the treatment of glucocorticoid induced hyperglycemia using continuous glucose monitoring in hospitalized patients with type 2 diabetes and respiratory disease
Glucocorticoids are drugs widely used in medicine to treat many conditions. There exist several compounds of glucocorticoids with different pharmacokinetics, as well as different dosing regimens, depending on the particular treatment indications. One of the best-known adverse effects of glucocorticoid therapy is the deleterious effect on carbohydrate metabolism, worsening hyperglycemia in almost all person who already have diabetes or precipitating “steroid diabetes” in that people with no prior diabetes [1]. (Source: Diabetes Research and Clinical Practice)
Source: Diabetes Research and Clinical Practice - September 28, 2015 Category: Endocrinology Authors: María S. Ruiz de Adana, Natalia Colomo, Cristina Maldonado-Araque, María I Fontalba, Francisca Linares, Francisca García-Torres, Rosario Fernández, Carmen Bautista, Gabriel Olveira, J.L. de la Cruz, Gemma Rojo-Martínez, Sergio Valdés Source Type: research

High prevalence of colonization of oral cavity by respiratory pathogens in frail older patients with oropharyngeal dysphagia
Conclusions & InferencesFrail older patients with OD had impaired health status, poor oral health, high oral bacterial load, and prevalence of oral colonization by respiratory pathogens and VFS signs of impaired safety of swallow, and were therefore at risk for contracting AP. Aspiration pneumonia and oral colonization in patients oropharyngeal dysphagia (OD) are very related. We studied and compared oral colonization by respiratory pathogens in older patietns with OD and a control group. We found higher colonization by respiratory pathogens in the oral cavity of older patients with OD. (Source: Neurogastroenterology and Motility)
Source: Neurogastroenterology and Motility - September 28, 2015 Category: Gastroenterology Authors: O. Ortega, O. Sakwinska, S. Combremont, B. Berger, J. Sauser, C. Parra, S. Zarcero, J. Nart, S. Carrión, P. Clavé Tags: Original Article Source Type: research

Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA)
Conclusion These data indicate that PVP-I-based hand wash products for potentially contaminated skin, and PVP-I gargle/mouthwash for reduction of viral load in the oral cavity and the oropharynx, may help to support hygiene measures to prevent transmission of MERS-CoV. Funding Mundipharma Research GmbH & Co. (Source: Infectious Diseases and Therapy)
Source: Infectious Diseases and Therapy - September 28, 2015 Category: Infectious Diseases Source Type: research

Moving Knowledge Acquisition From the Lecture Hall to the Student Home: A Prospective Intervention Study
Conclusions: When used in conjunction with quiz questions, podcasts have the potential to foster knowledge acquisition and retention over and above the effect of live lectures. (Source: Journal of Medical Internet Research)
Source: Journal of Medical Internet Research - September 28, 2015 Category: Journals (General) Authors: Tobias RaupachClemens GrefeJamie BrownKatharina MeyerNikolai SchuelperSven Anders Source Type: research

Feasibility and reproducibility of BOLD and TOLD measurements in the liver with oxygen and carbogen gas challenge in healthy volunteers and patients with hepatocellular carcinoma
Conclusion measurements in HCC and liver parenchyma are more reproducible at 1.5T than at 3.0T, and with O2 than with CB challenge. We observed a decrease in and an increase in R1 of HCCs from baseline in response to O2 challenge, as expected with increased tissue and blood oxygenation. J. Magn. Reson. Imaging 2015. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - September 28, 2015 Category: Radiology Authors: Octavia Bane, Cecilia Besa, Mathilde Wagner, Niels Oesingmann, Hongfa Zhu, Maria Isabel Fiel, Bachir Taouli Tags: Original Research Source Type: research

Elongator-dependent modification of cytoplasmic tRNALysUUU is required for mitochondrial function under stress conditions
To gain a wider view of the pathways that regulate mitochondrial function, we combined the effect of heat stress on respiratory capacity with the discovery potential of a genome-wide screen in Saccharomyces cerevisiae. We identified 105 new genes whose deletion impairs respiratory growth at 37°C by interfering with processes such as transcriptional regulation, ubiquitination and cytosolic tRNA wobble uridine modification via 5-methoxycarbonylmethyl-2-thiouridine formation. The latter process, specifically required for efficient decoding of AA-ending codons under stress conditions, was covered by multiple genes belongin...
Source: Nucleic Acids Research - September 28, 2015 Category: Research Authors: Tigano, M., Ruotolo, R., Dallabona, C., Fontanesi, F., Barrientos, A., Donnini, C., Ottonello, S. Tags: Molecular Biology Source Type: research

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses
RNA viruses encode an RNA-dependent RNA polymerase (RdRp) that catalyzes the synthesis of their RNA(s). In the case of positive-stranded RNA viruses belonging to the order Nidovirales, the RdRp resides in a replicase subunit that is unusually large. Bioinformatics analysis of this non-structural protein has now revealed a nidoviral signature domain (genetic marker) that is N-terminally adjacent to the RdRp and has no apparent homologs elsewhere. Based on its conservation profile, this domain is proposed to have nucleotidylation activity. We used recombinant non-structural protein 9 of the arterivirus equine arteritis virus...
Source: Nucleic Acids Research - September 28, 2015 Category: Research Authors: Lehmann, K. C., Gulyaeva, A., Zevenhoven-Dobbe, J. C., Janssen, G. M. C., Ruben, M., Overkleeft, H. S., van Veelen, P. A., Samborskiy, D. V., Kravchenko, A. A., Leontovich, A. M., Sidorov, I. A., Snijder, E. J., Posthuma, C. C., Gorbalenya, A. E. Tags: Nucleic Acid Enzymes Source Type: research

Electronic nose analysis of exhaled breath to diagnose ventilator-associated pneumonia
Exhaled breath analysis is an emerging technology in respiratory disease and infection. Electronic nose devices (e-nose) are small and portable with a potential for point of care application. Ventilator-associated pneumonia (VAP) is a common nosocomial infection occurring in the intensive care unit (ICU). The current best diagnostic approach is based on clinical criteria combined with bronchoalveolar lavage (BAL) and subsequent bacterial culture analysis. BAL is invasive, laborious and time consuming. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - September 28, 2015 Category: Respiratory Medicine Authors: R.M. Schnabel, M.L.L. Boumans, A. Smolinska, E.E. Stobberingh, R. Kaufmann, P.M.H.J. Roekaerts, D.C.J.J. Bergmans Source Type: research

Bronchopulmonary infection–colonization patterns in Spanish cystic fibrosis patients: Results from a national multicenter study
Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - September 28, 2015 Category: Respiratory Medicine Authors: Juan de Dios Caballero, Rosa del Campo, Ana Royuela, Amparo Solé, Luis Máiz, Casilda Olveira, Esther Quintana-Gallego, Javier de Gracia, Marta Cobo, Elia Gómez G. de la Pedrosa, Antonio Oliver, Rafael Cantón, GEIFQ (Grupo Español para el Estudio de l Tags: Original Article Source Type: research

Dose Optimization Study of AEOL 10150 as a Mitigator of Radiation-Induced Lung Injury in CBA/J Mice.
In conclusion, treatment with AEOL 10150 at a dose of 25 mg/kg/day for a total of 28 days starting 24 h after WTLI in CBA/J mice was found to be the optimal dose with improvement in survival and lung function. Future studies will be required to determine the optimal duration and therapeutic window for drug delivery at this dose. PMID: 26414508 [PubMed - as supplied by publisher] (Source: Radiation Research)
Source: Radiation Research - September 28, 2015 Category: Physics Authors: Murigi FN, Mohindra P, Hung C, Salimi S, Goetz W, Pavlovic R, Jackson IL, Vujaskovic Z Tags: Radiat Res Source Type: research

Ultrasound-guided bilateral stellate ganglion blockade to treat digital ischemia in a patient with sepsis: a case report.
CONCLUSIONS: This case illustrates the potential advantages of ultrasound-guided stellate ganglion blockade for the treatment of sepsis-related digital ischemia refractory to standard therapy. PMID: 26415545 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - September 28, 2015 Category: Anesthesiology Authors: Bataille B, Nucci B, Mora M, Silva S, Cocquet P Tags: Can J Anaesth Source Type: research

Sedation versus general anaesthesia for provision of dental treatment to patients younger than 18 years.
CONCLUSIONS: Randomized controlled studies comparing use of dental general anaesthesia versus sedation are needed to quantify differences such as morbidity and cost. PMID: 26413895 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 28, 2015 Category: Journals (General) Authors: Ashley PF, Williams CE, Moles DR, Parry J Tags: Cochrane Database Syst Rev Source Type: research

Novel pseudorabies virus variant with defects in TK, gE and gI protects growing pigs against lethal challenge.
Abstract One of the distinct features of the emerging Chinese pseudorabies virus (PRV) variant is its ability to cause severe neurological signs and high mortality in growing pigs in Bartha-K61-vaccinated pig farms. Either single- or multiple-gene-deleted live vaccine candidates have been developed; however, none was evaluated thoroughly in growing pigs. Here, we generated rSMXΔgI/gEΔTK, an attenuated PRV variant with defects in TK, gI and gE genes. The growth kinetics of the attenuated virus was similar to the wild type (wt) strain. It was safe for 1-day-old piglets. Twenty one-day-old weaned pigs were immunized...
Source: Vaccine - September 28, 2015 Category: Allergy & Immunology Authors: Hu RM, Zhou Q, Song WB, Sun EC, Zhang MM, He QG, Chen HC, Wu B, Liu ZF Tags: Vaccine Source Type: research

Frequent IgG subclass and mannose binding lectin deficiency in patients with Chronic Fatigue Syndrome.
In this study we retrospectively analysed 300 patients with CFS for immunoglobulin and MBL levels, and B-cell subset frequencies. 25% of the CFS patients had decreased serum levels of at least one antibody class or subclass with IgG3 and IgG4 subclass deficiencies as most common phenotypes. However, we found elevated immunoglobulin levels with an excess of IgM and IgG2 in particular in another 25% of patients. No major alteration in numbers of B cells and B-cell subsets was seen. Deficiency of MBL was found in 15% of the CFS patients in contrast to 6% in a historical control group. In a 2(nd) cohort of 168 patients similar...
Source: Human Immunology - September 28, 2015 Category: Allergy & Immunology Authors: Guenther S, Loebel M, Mooslechner AA, Knops M, Hanitsch LG, Grabowski P, Wittke K, Meisel C, Unterwalder N, Volk HD, Scheibenbogen C Tags: Hum Immunol Source Type: research

C. elegans ATAD-3 modulates mitochondrial iron and heme homeostasis.
In conclusion, our data indicate a regulatory role of Caenorhabditis elegans ATAD-3 in mitochondrial iron and heme metabolism. PMID: 26427876 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - September 28, 2015 Category: Biochemistry Authors: van den Ecker D, Hoffmann M, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F Tags: Biochem Biophys Res Commun Source Type: research

The absorption and metabolism of a single L-menthol ORAL versus SKIN administration: Effects on thermogenesis and metabolic rate.
Abstract We investigated the absorption and metabolism pharmacokinetics of a single L-menthol oral versus skin administration and the effects on human thermogenesis and metabolic rate. Twenty healthy adults were randomly distributed into oral (capsule) and skin (gel) groups and treated with 10 mg·kg(-1) L-menthol (ORALMENT; SKINMENT) or control (lactose capsule: ORALCON; water application: SKINCON) in a random order on two different days. Levels of serum L-menthol increased similarly in ORALMENT and SKINMENT (p>0.05). L-menthol glucuronidation was greater in ORALMENT than SKINMENT (p<0.05). Cutaneous vasocon...
Source: Food and Chemical Toxicology - September 28, 2015 Category: Food Science Authors: Valente A, Carrillo AE, Tzatzarakis MN, Vakonaki E, Tsatsakis AM, Kenny GP, Koutedakis Y, Jamurtas AZ, Flouris AD Tags: Food Chem Toxicol Source Type: research