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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Successful thrombolytic therapy of post‐operative massive pulmonary embolism after ultralong cardiopulmonary resuscitation: a case report and review of literature
ConclusionsThrombolytic therapy is useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive PE during the perioperative period, even in the prolong resuscitation. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 24, 2015 Category: Respiratory Medicine Authors: Yanxia Yu, Zhenguo Zhai, Yuanhua Yang, Wanmu Xie, Chen Wang Tags: Other Source Type: research

Pulmonary melioidosis presenting with pleural effusion: a case report and review of literature
We report a case of pulmonary melioidosis with the initial presentation mimicking a partially treated pneumonia complicated by right-sided pleural effusion. The patient is a 49-year old man who did not respond to parenteral ceftriaxone and tazobactam/piperacillin therapy. However, upon culture and sensitivity results from blood and pleural samples isolated Burkholderia pseudomallei; antimicrobial therapy was de-escalated to parenteral ceftazidime. Within 72 hours duration, his fever subsided and other respiratory symptoms improved tremendously. This case highlights the importance of early recognition of Burkholderia pseudo...
Source: Respiratory Medicine Case Reports - July 24, 2015 Category: Respiratory Medicine Source Type: research

Cytisine is more effective than nicotine replacement for smoking cessation
Commentary on: Walker N, Howe C, Glover M, et al. Cytisine versus nicotine for smoking cessation. N Engl J Med 2014;371: 2353–62. Context Smoking is a nicotine-based addiction affecting about a billion people worldwide.1 Inhaling the tars and carbon monoxide from burned tobacco causes the premature death of about two-thirds of those who smoke throughout their lives and is the leading cause of preventable mortality and morbidity.2 Effective pharmacological therapies have helped reduce smoking prevalence in wealthier countries, but are prohibitively expensive in poorer countries where smoking is most prevalent.3 4 Cyti...
Source: Evidence-Based Medicine - July 24, 2015 Category: Internal Medicine Authors: Stapleton, J. A. Tags: Smoking and tobacco, Clinical trials (epidemiology), Epidemiologic studies, Drugs: CNS (not psychiatric), Sleep disorders (neurology), Sleep disorders, Sleep disorders (respiratory medicine), Health education, Smoking Therapeutics/Prevention Source Type: research

Varenicline can help smokers to stop smoking by gradual reduction
Commentary on: Ebbert JO, Hughes JR, West RJ, et al. Effect of varenicline on smoking cessation through smoking reduction: a randomised clinical trial. JAMA 2015;313:687–94. Context Around 70% of smokers say they want to quit smoking. However, if they are asked to set a quit date ‘right now’, the figure comes down to around 5–10%. In practice, we need to realise that there is a range of motivation for change. Smokers can be grouped into those wanting and not wanting to quit. Among those wanting to quit, some may have tried and failed so many times that they have more or less given up trying. Among t...
Source: Evidence-Based Medicine - July 24, 2015 Category: Internal Medicine Authors: Fagerstrom, K. Tags: Journalology, Smoking and tobacco, Clinical trials (epidemiology), Editor's choice, Sleep disorders (neurology), Sleep disorders, Sleep disorders (respiratory medicine), Ethics, Health education, Smoking Therapeutics/Prevention Source Type: research

Repetitive nerve stimulation and single‐fiber electromyography in the evaluation of patients with suspected myasthenia gravis or Lambert–Eaton myasthenic syndrome: Review of recent literature
Conclusions: Electrodiagnostic testing continues to be useful for diagnosis of MG and LEMS, although the quality of the evidence is not great. This literature review summarizes RNS and jitter measurement of facial and respiratory muscles and use of concentric needle EMG for SFEMG. Muscle Nerve, 2015 (Source: Muscle and Nerve)
Source: Muscle and Nerve - July 24, 2015 Category: Internal Medicine Authors: Faye Y. Chiou‐Tan, James M. Gilchrist Tags: AANEM Technology Review Source Type: research

Screening of a clinically and biochemically diagnosed SOD patient using exome sequencing: A case report with a mutations/variations analysis approach
Conclusion In this study, about ten classes of genes were introduced as candidate genes involved in SOD However, future studies are necessary to examine these reported genes in more details on how these genes may relate to each other and contribute to the pathology of SOD disease. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - July 24, 2015 Category: Genetics & Stem Cells Source Type: research

Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma
by Blanca E. Himes, Cynthia Koziol-White, Martin Johnson, Christina Nikolos, William Jester, Barbara Klanderman, Augusto A. Litonjua, Kelan G. Tantisira, Kevin Truskowski, Kevin MacDonald, Reynold A. Panettieri, Scott T. Weiss Globally, asthma is a chronic inflammatory respiratory disease affecting over 300 million people. Some asthma patients remain poorly controlled by conventional therapies and experience more life-threatening exacerbations. Vitamin D, as an adjunct therapy, may improve disease control in severe asthma patients since vitamin D enhances glucocorticoid responsiveness and mitigates airway smooth muscle (A...
Source: PLoS One - July 24, 2015 Category: Biomedical Science Authors: Blanca E. Himes et al. Source Type: research

Activation of immunity, immune response, antioxidant ability, and resistance against Vibrio alginolyticus in white shrimp Litopenaeus vannamei decrease under long-term culture at low pH
Publication date: October 2015 Source:Fish & Shellfish Immunology, Volume 46, Issue 2 Author(s): Yu-Yuan Chen, Jiann-Chu Chen, Kuei-Chi Tseng, Yong-Chin Lin, Chien-Lun Huang The growth, activation of immunity, immune parameters, and transcript levels of cytMnSOD, mtMnSOD, ecCuZnSOD, glutathione peroxidase (GPx), catalase, lysozyme, and penaeidin 3a were examined in white shrimp Litopenaeus vannamei reared at pH 6.8 and 8.1 after 24 weeks. No significant difference in growth was observed between the two groups. An in vitro study indicated that phenoloxidase activity and respiratory bursts (RB, release of the...
Source: Fish and Shellfish Immunology - July 24, 2015 Category: Biology Source Type: research

Asymptomatic children might transmit human parechovirus type 3 to neonates and young infants
Human parechoviruses (HPeVs) are RNA viruses closely related to enteroviruses, in the family Picornaviridae[1]. Like enteroviruses, HPeVs replicate mainly in the gut and are transmitted via the fecal–oral route, although the virus is also shed from the nasopharynx [2]. In general, infection with HPeVs is asymptomatic or causes mild disease, including respiratory tract infections and gastroenteritis in children, and the virus is frequently detected in stool samples from such patients [2,3]. HPeV3 is a newly recognized pathogen that can cause sepsis and meningoencephalitis in neonates/young infants [4–6]. (Source: Journa...
Source: Journal of Clinical Virology - July 24, 2015 Category: Virology Authors: Yuta Aizawa, Takayuki Yamanaka, Kanako Watanabe, Tomohiro Oishi, Akihiko Saitoh Tags: Short communication Source Type: research

RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus
Publication date: Available online 23 July 2015 Source:Cell Reports Author(s): Jill M. Perreira, Aaron M. Aker, George Savidis, Christopher R. Chin, William M. McDougall, Jocelyn M. Portmann, Paul Meraner, Miles C. Smith, Motiur Rahman, Richard E. Baker, Annick Gauthier, Michael Franti, Abraham L. Brass Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host proteins that modulate HRV replication. Here, we show that RNASEK, a transmembrane protein, was needed for the replication of HRV, influenza A virus, ...
Source: Cell Reports - July 24, 2015 Category: Cytology Source Type: research

Knowledge and Attitudes Regarding Antibiotic Use Among Adult Consumers, Adult Hispanic Consumers, and Health Care Providers - United States, 2012-2013.
Abstract Appropriate antibiotic use, in particular avoidance of antibiotics for upper respiratory infections likely to be caused by viruses, is a key component of efforts to slow the increase in antibiotic-resistant infections. Studies suggest that Hispanic consumers might differ from non-Hispanic consumers in their knowledge and attitudes regarding antibiotic use (4). To better understand health care provider and consumer knowledge and attitudes that influence antibiotic use, CDC analyzed national internet survey data collected from participants living in the United States during 2012-2013. The participants repres...
Source: MMWR Morb Mortal Wkl... - July 24, 2015 Category: Epidemiology Authors: Francois Watkins LK, Sanchez GV, Albert AP, Roberts RM, Hicks LA Tags: MMWR Morb Mortal Wkly Rep Source Type: research

The perception of allergen-specific immunotherapy among pediatricians in the primary care setting
Conclusion: AIT is in general well known and accepted among PCP, although a more intense divulgation effort is required. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - July 24, 2015 Category: Allergy & Immunology Authors: Massimo LandiPaolo MeglioErmanno PraitanoCarlo LombardiGiovanni PassalacquaGiorgio Canonica Source Type: research

Does azithromycin modify viral load during severe respiratory syncytial virus bronchiolitis?
Early life respiratory syncytial virus (RSV) bronchiolitis is a major risk factor for subsequent recurrent wheezing and asthma.1,2 The highest asthma risk occurs in infants with severe bronchiolitis requiring hospitalization3: up to 75% of hospitalized infants experience at least 3 additional wheezing episodes and almost 50% are diagnosed with asthma by the age of 7 years.1 (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - July 24, 2015 Category: Allergy & Immunology Authors: Avraham Beigelman, Leonard B. Bacharier, Jack Baty, Richard Buller, Sheila Mason, Kenneth B. Schechtman, Geneline Sajol, Megan Isaacson-Schmid, Mario Castro, Gregory A. Storch Tags: Letter to the Editor Source Type: research

Book me a room! (I have allergies and asthma)
As allergists, we understand the role of allergic triggering in the generation of upper and lower respiratory symptoms, eye symptoms, and general well-being.1 We ask our patients to keep the cat away, manage dust mites, keep windows closed during pollen season, and fix leaks around windows, bathtubs, and basements. On our recommendation, patients modify their bedrooms, bathrooms, and basements to improve their general health and lessen their total medication load. While traveling, the clinical stability of the modified home is traded for a potentially allergen-laden environment, leading to increased symptoms and a decrease...
Source: Annals of Allergy, Asthma and Immunology - July 24, 2015 Category: Allergy & Immunology Authors: Mark Lazarovich Tags: Perspective Source Type: research

The effect of continuous interscalene brachial plexus block with 0.125% bupivacaine vs 0.2% ropivacaine on pain relief, diaphragmatic motility, and ventilatory function
Outpatient continuous interscalene brachial plexus blocks containing bupivacaine or ropivacaine are commonly used to control pain after shoulder surgery. Interscalene blocks cause hemidiaphragmatic paresis. Because ropivacaine preferentially blocks sensory fibers, it may cause less blockade of the phrenic nerve. The purpose of this study was to evaluate the effects of 2 common continuous interscalene brachial plexus infusions: 0.125% bupivacaine vs 0.2% ropivacaine. The study hypothesis is that respiratory function will be less attenuated using ropivacaine than bupivacaine without affecting pain relief. (Source: Journal of...
Source: Journal of Clinical Anesthesia - July 24, 2015 Category: Anesthesiology Authors: Dominik W. Choromanski, Pranav S. Patel, Joel M. Frederick, Stephen E. Lemos, Elie J. Chidiac Tags: Original contribution Source Type: research

Point-of-care testing for respiratory viruses in adults: the current landscape and future potential
Respiratory viruses are responsible for a large proportion of acute respiratory illness in adults as well as children, and are associated with a huge socio-economic burden worldwide. Development of accurate point-of-care tests (POCT) for respiratory viruses has been listed as a priority by the World Health Organisation and replacing the current paradigm of empirical antimicrobial use with directed use is a listed goal of the movement for reduction in antimicrobial resistance. POCTs for respiratory viruses have previously been limited by the poor sensitivity of antigen detection based tests and by a limited range of detecta...
Source: Journal of Infection - July 24, 2015 Category: Infectious Diseases Authors: Nathan J. Brendish, Hannah F. Schiff, Tristan W. Clark Source Type: research

Sinomonas halotolerans sp. nov., an actinobacterium isolated from a soil sample.
Abstract A novel actinobacterial strain, designated CFH S0499(T), was isolated from a soil sample collected from Catba island in Halong Bay, Vietnam. The cells were observed to be Gram-stain positive, aerobic, non-motile, curved rods. The strain was found to grow optimally at 28 °C and pH 7.0. Growth was found to occur at 0-7 % NaCl. Chemotaxonomically, the peptidoglycan type was determined to be of the A3α type, with glutamic acid, glycine, alanine and lysine as the major cell wall amino acids. The whole cell sugars were found to contain mannose, galactose, glucose, ribose and rhamnose. The polar lipids were i...
Source: Antonie van Leeuwenhoek - July 24, 2015 Category: Microbiology Authors: Guo QQ, Ming H, Meng XL, Huang JR, Duan YY, Li SH, Li S, Zhang JX, Li WJ, Nie GX Tags: Antonie Van Leeuwenhoek Source Type: research

Long-term adherence to inhaled corticosteroids in children with asthma: Observational study
Non-adherence to daily controller medication in childhood asthma is strongly dependent on potentially modifiable factors such as parental illness perceptions and medication beliefs. The extent to which adherence in children can be improved by addressing modifiable determinants of non-adherence has not been studied to date, however. We assessed long-term adherence and its determinants in children with asthma enrolled in a comprehensive asthma care program employing shared decision making with parents. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 24, 2015 Category: Respiratory Medicine Authors: Ted Klok, Adrian A. Kaptein, Eric J. Duiverman, Paul L. Brand Source Type: research

Can biliary endoscopy play a role in liver disease associated to cystic fibrosis?
Biliopathy associated to cystic fibrosis (CF) is a relatively rare condition in adult patients. Recently, an increase in life expectancy for patients with cystic fibrosis (CF) has been reported. Therefore, a new clinical picture related to CF- associated liver involvement is quite often observed [1]. The involvement of the biliary tree has been hypothesized as having a pivotal role in the pathogenesis and evolution of liver cirrhosis, but there is a lack of systematic data about it [1,2]. The impact of endotherapy on the biliopathy and liver disease in adult cystic fibrosis patients needs sistematic evaluation with a long-...
Source: Journal of Cystic Fibrosis - July 24, 2015 Category: Respiratory Medicine Authors: P. Cantù, L. Claut, A. Elvevi, I. Parzanese, M. Maggioni, D. Conte, R. Penagini, C. Colombo Tags: Letter to the Editor Source Type: research

Effects of positive end-expiratory pressure on brain tissue oxygen pressure of severe traumatic brain injury patients with acute respiratory distress syndrome: a pilot study
: To verify whether high positive end-expiratory pressure levels can increase brain tissue oxygen pressure, and also their effects on pulse oxygen saturation, intracranial pressure and cerebral perfusion pressure. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 24, 2015 Category: Intensive Care Authors: Sérgio Nogueira Nemer, Jefferson B. Caldeira, Ricardo G. Santos, Bruno L. Guimarães, João Márcio Garcia, Darwin Prado, Ricardo T. Silva, Leandro M. Azeredo, Eduardo R. Faria, Paulo Cesar P. Souza Source Type: research

Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice
Non-alcoholic fatty liver disease has been considered the hepatic manifestation of obesity. It is unclear whether supplementation with green tea extract rich in epigallocathechin-3-gallate (EGCG) influences the activity of mitochondrial respiratory chain complexes and insulin resistance in the liver. EGCG regulated hepatic mitochondrial respiratory chain complexes and was capable of improving lipid metabolism, attenuating insulin resistance in obese mice. The mice were divided into four groups: control diet+water (CW) or EGCG (CE); hyperlipidic diet+water (HFW) or EGCG (HFE). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - July 24, 2015 Category: Biochemistry Authors: A.B. Santamarina, M. Carvalho-Silva, L.M. Gomes, M.H. Okuda, A.A. Santana, E.L. Streck, M. Seelaender, C.M. Oller do Nascimento, E.B. Ribeiro, F.S. Lira, L.M. Oyama Source Type: research

Urine Nested Polymerase Chain Reaction in Neonatal Septicemia
This cross-sectional study was done to evaluate diagnostic efficacy of urine nested polymerase chain reaction (PCR) using broad-range 16SrDNA PCR-based amplification, followed by restriction analysis and sequencing in neonatal septicemia. The study included 50 babies; 48% had vaginal delivery, 46% were preterm, 20% had a history of prolonged rupture of membranes and 56% were low birth weight (≤2500 g). Clinical presentations were lethargy (96%), respiratory distress (80%) and bleeding diathesis (16%). Absolute neutrophil count <1800/mm3 was observed in 60%, and positive C-reactive protein in 46%. Thirty neonates had ...
Source: Journal of Tropical Pediatrics - July 24, 2015 Category: Tropical Medicine Authors: Das, B. K., Suri, S., Nath, G., Prasad, R. Tags: Original Papers Source Type: research

Protocadherin-1 binds to SMAD3 and suppresses TGFβ1-induced gene transcription.
In conclusion, we demonstrate that PCDH1 binds to SMAD3 and regulates its activation by TGF-β signaling in bronchial epithelial cells. We propose that PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects the sensitivity of the airway epithelium to TGF-β. PMID: 26209277 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman RM, Hackett TL, Willemse BW, Holloway J, Van Roy F, Koppelman GH, Nawijn MC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Regulation of Allergic Lung Inflammation by Endothelial Cell Transglutaminase 2.
Abstract Tissue transglutaminase 2 (TG2) is an enzyme with multiple functions, including catalysis of serotonin conjugation to proteins (serotonylation). Previous research indicates that TG2 expression is upregulated in human asthma and in the lung endothelium of OVA-challenged mice. It is not known whether endothelial TG2 is required for allergic inflammation. Therefore, to determine whether endothelial cell TG2 regulates allergic inflammation, mice with an endothelial cell-specific deletion of TG2 were generated, and then these mice were sensitized and challenged in the airways with OVA. Deletion of TG2 in endoth...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Soveg F, Abdala-Valencia H, Campbell J, Morales-Nebreda L, Mutlu GM, Cook-Mills JM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Murine and human CFTR exhibit different sensitivities to CFTR potentiators.
Abstract Development of therapeutic molecules with clinical efficacy as modulators of defective CFTR includes efforts to identify potentiators which can overcome or repair the gating defect in mutant CFTR channels. This has taken a great leap forward with the identification of the potentiator VX-770, now available to patients as "Kalydeco". Other small molecules with different chemical structure also are capable of potentiating the activity of either wildtype or mutant CFTR, suggesting that there are features of the protein that may be targeted in order to achieve stimulation of channel activity by structurally div...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Cui G, McCarty NA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

NAD(P)H oxidase subunit p47phox is elevated and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.
Abstract Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance that are caused, in part, by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormalities in CHF is unclear. The p47(phox)-dependent Nox2 isoform of NAD(P)H oxidase is a putative source of diaphragm oxidants. Thus, we conducted our study with the goal of determining the effects of CHF on diaphragm abundance of Nox2 complex subunits and test the hypothesis that p47(phox) knockout prevents diaphr...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Ahn BS, Beharry AW, Frye GS, Judge AR, Ferreira LF Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Cigarette smoke induced disruption of pulmonary barrier and bacterial translocation drive tumor associated inflammation and growth.
Abstract Microorganisms have an important role in tumorgenesis by the induction of inflammation and by a direct impact on tumor cells. Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and microbial colonization. We asked whether bacterial pathogens act as tumor promoters during CS-induced pulmonary inflammation. In a metastatic lung cancer (LC) model, Lewis lung carcinoma (LLC) cells were injected in mice to initiate the growth of tumors in the lung. Exposure to the combination of cigarette smoke (CS) and non-typeable Haemophilus influenzae (NTHi) synergistically inc...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Jungnickel C, Wonnenberg B, Karabiber O, Wolf A, Voss M, Wolf L, Honecker A, Kamyschnikow A, Herr C, Bals R, Beisswenger C Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Precision Medicine: At What Price.
Abstract Not applicable. PMID: 26207804 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 24, 2015 Category: Respiratory Medicine Authors: Ferkol T, Quinton P Tags: Am J Respir Crit Care Med Source Type: research

Regulation of 26S Proteasome Activity in Pulmonary Fibrosis.
CONCLUSION: Our study identifies Rpn6-dependent 26S proteasome activation as an essential feature of myofibroblast differentiation in vitro and in vivo and suggests an important role in IPF pathogenesis. PMID: 26207697 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 24, 2015 Category: Respiratory Medicine Authors: Semren N, Welk V, Korfei M, Keller IE, Fernandez IE, Adler H, Günther A, Eickelberg O, Meiners S Tags: Am J Respir Crit Care Med Source Type: research

Blindness and Deafness as Initial Manifestation of Non-small Cell Lung Cancer.
PMID: 26216716 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Nascimento LM, Reis R, Fernandes A Tags: Arch Bronconeumol Source Type: research

Long-term Outcome of Patients With Undiagnosed Pleural Effusion.
CONCLUSION: Although the probability is low, some patients with exudative pleural effusion undiagnosed after pleural biopsy via video-assisted thoracoscopic surgery may have malignant disease. Patients with an initially large volume of effusion that re-accumulates after examination should be closely monitored. PMID: 26216715 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Gunluoglu G, Olcmen A, Gunluoglu MZ, Dincer I, Sayar A, Camsari G, Yilmaz V, Altin S Tags: Arch Bronconeumol Source Type: research

Inhaled corticosteroids in chronic obstructive pulmonary disease: Some considerations.
PMID: 26216714 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Baloira Villar A, Núñez Fernández M, Pallarés Sanmartín A Tags: Arch Bronconeumol Source Type: research

Digital gene expression analysis of transcriptomes in lipopolysaccharide-induced acute respiratory distress syndrome.
CONCLUSIONS: Using the powerful technology of DGE, we present, to our knowledge, the first in-depth transcriptomic analysis of mouse lungs after LPS exposure. We found some differentially expressed genes that might play important roles in the pathogenesis of ARDS. PMID: 26216187 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 24, 2015 Category: Chemistry Authors: Lv XJ, Zhang YJ, Lu WZ, Wang Q, Li SY, Guo L, Qian GS, Zhou SW, Li YY Tags: Clin Chim Acta Source Type: research

Short-term exposure to L-type calcium channel blocker, verapamil alters the expression pattern of calcium binding proteins in the brain of goldfish, Carassius auratus.
Abstract Influx of calcium ions (Ca(2+)) is responsible for various physiological events including neurotransmitter release and synaptic modulation. The L-type voltage dependent calcium channels (L-type VDCCs) transport Ca(2+) across membrane. Calcium binding proteins (CaBPs) bind free cytosolic Ca(2+) and prevent excitotoxicity caused by sudden increase in cytoplasmic Ca(2+). The present study was aimed to understand the regulation of expression of neuronal CaBPs namely, calretinin (CR) and parvalbumin (PV) following blockade of L-type VDCCs in the CNS of Carassius auratus. Verapamil (VRP), a potent L-type VDCC bl...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - July 24, 2015 Category: Biochemistry Authors: Palande NV, Bhoyar RC, Biswas SP, Jadhao AG Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: research

[Neurally adjusted ventilatory assist increases respiratory variability and improves patient-ventilator synchronisation].
PMID: 26216280 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - July 24, 2015 Category: Pediatrics Authors: García-Muñoz Rodrigo F, Urquía Marti L, Galán Henríquez G, Rivero Rodríguez S, Siles Quesada C Tags: An Pediatr (Barc) Source Type: research

Massilia arvi sp. nov., a bacterium isolated from fallow land soil previously cultivated with Brassica oleracea and emended description of the genus Massilia.
Abstract A novel bacterial strain designated as THG-RS2OT, was isolated from fallow land soil previously cultivated with Brassica oleracea in Yongin, South Korea. Cells were Gram-stain-negative, aerobic, non-motile rods, catalase and oxidase positive. Strain THG-RS2OT grows optimally at 25-37 °C, at pH 7.0 and in absence of NaCl. 16S rRNA gene sequence analysis demonstrated that strain THG-RS2OT shows highest sequence similarity with Massilia kyonggiensis KACC 17471 followed by Massilia aerilata KACC 12505T, Massilia niastensis KACC 12599T, Massilia tieshanensis KACC 14940T and Massilia haematophila KCTC 32001T. L...
Source: International Journal of Systematic and Evolutionary Microbiology - July 24, 2015 Category: Microbiology Authors: Singh H, Du J, Won K, Yang JE, Yin C, Kook M, Yi TH Tags: Int J Syst Evol Microbiol Source Type: research

Bordetella bronchialis sp. nov., Bordetella flabilis sp. nov. and Bordetella sputigena sp. nov., isolated from human respiratory specimens, and reclassification of Achromobacter sediminum (Zhang et al. 2014) as Verticia sediminum gen. nov., comb. nov.
Abstract The phenotypic and genotypic characteristics of four Bordetella hinzii-like strains from human respiratory specimens and representing nrdA gene sequence based genogroups 3, 14 and 15 were examined. In a 16S rRNA gene sequence based phylogenetic tree, the four strains consistently formed a single coherent lineage but their assignment to the genus Bordetella was equivocal. The respiratory quinone, polar lipid and fatty acid profiles generally conformed to those of Bordetella species and were characterized by the presence of ubiquinone 8, of phosphatidylethanolamine, phosphatidylglycerol, diphosphatidylglycer...
Source: International Journal of Systematic and Evolutionary Microbiology - July 24, 2015 Category: Microbiology Authors: Vandamme PA, Peeters C, Cnockaert M, Inganäs E, Falsen E, Moore ER, Nunes OC, Manaia CM, Spilker T, LiPuma JJ Tags: Int J Syst Evol Microbiol Source Type: research

Development of port‐site metastases following thoracoscopic resection of a neuroblastoma
We report a 26‐month‐old female who developed port‐site metastases of a neuroblastoma following minimally invasive thoracoscopic interventions. After diagnosis of an intrathoracic low‐risk neuroblastoma and 6 months of observation, she developed respiratory problems. She subsequently underwent total resection of a locally progressive tumor via thoracoscopy. Six months later, she developed local relapse and subcutaneous metastases within the thoracic wall. These port‐site metastases were most likely iatrogenic. After excision of metastases, the residual tumor responded well to salvage chemotherapy. The patient has...
Source: Pediatric Blood and Cancer - July 23, 2015 Category: Cancer & Oncology Authors: Falk Pentek, Johannes H. Schulte, Bernd Schweiger, Martin Metzelder, Michael M. Schündeln Tags: Brief Report Source Type: research

Sequence variants on 17q21 are associated with the susceptibility of asthma in the population of Lahore, Pakistan
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - July 23, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Endotracheal Tube Management and Obstructed Airway
Thoracic surgery encompasses a wide array of surgical techniques, most of which require lung isolation for surgical exposure in the pleural cavity; this, in turn, demands an extensive knowledge of respiratory mechanics and modalities of airway control. Likewise, effective treatment of an acute central airway obstruction calls for a systematic approach using clear communication between teams and a comprehensive knowledge of available therapeutic modalities by the surgeon. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - July 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Manu Sancheti, Seth Force Source Type: research

Dexmedetomidine for tracheal extubation in deeply anesthetized adult patients after otologic surgery: a comparison with remifentanil
Background: Remifentanil and dexmedetomidine are well known to suppress airway reflexes during airway procedures. Smooth tracheal extubation is important after otologic surgery. The purpose of this study is to compare the effectiveness of dexmedetomidine or remifentanil infusion for producing smooth tracheal extubation in deeply anesthetized patients after otologic surgery. Methods: Seventy-four ASA I-II adult patients (18-60 years old) scheduled for elective otologic surgery were randomly assigned to one of three groups: sevoflurane-remifentanil (Group SR, n = 25), sevoflurane-dexmedetomidine (0.5 μg/kg) (Group SD5,...
Source: BMC Anesthesiology - July 23, 2015 Category: Anesthesiology Authors: Qing FanChunbo HuMin YeXia Shen Source Type: research

Humidification devices
Publication date: Available online 21 July 2015 Source:Anaesthesia &amp; Intensive Care Medicine Author(s): David R. Ball Humidification is a process of adding water vapour to a volume of one or more gases. Natural humidification is achieved in the nasal cavity, but this process is often bypassed during anaesthesia and critical care. Various devices are used for artificial humidification, the most common is heat and moisture exchanger combined with a microbial filter. Electrically heated water baths may be used; new devices are combined with high-flow oxygen delivery to provide non-invasive respiratory support. (Sou...
Source: Anaesthesia and intensive care medicine - July 23, 2015 Category: Anesthesiology Source Type: research

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current study, we aimed to determine if exercise training in humans diminished P-CoA attenuation of mitochondrial ADP respiratory sensitivity. Six weeks of exercise training increased whole-body glucose homeostasis and skeletal muscle Akt signaling and reduced markers of oxidative stress without reducing maximal mitochond...
Source: Diabetes - July 23, 2015 Category: Endocrinology Authors: Ludzki, A.; Paglialunga, S.; Smith, B. K.; Herbst, E. A. F.; Allison, M. K.; Heigenhauser, G. J.; Neufer, P. D.; Holloway, G. P. Tags: Metabolism Source Type: research

Human Bocavirus 1 Primary Infection and Shedding in Infants
Conclusions HBoV-1 primary shedding events are associated with mild respiratory illness with subsequent prolonged detection of HBoV-1 DNA for up to a year. HBoV-1 reinfection contributes to long-term shedding. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - July 23, 2015 Category: Infectious Diseases Authors: Martin, E. T., Kuypers, J., McRoberts, J. P., Englund, J. A., Zerr, D. M. Tags: VIRUSES Source Type: research