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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.
Categorisation of Protein Respiratory Allergens: the Case of Subtilisin.
Abstract Characterisation of the relative sensitizing potency of protein and chemical allergens remains challenging, particularly for materials causing allergic sensitization of the respiratory tract. There nevertheless remains an appetite, for priority setting and risk management, to develop paradigms that distinguish between individual respiratory allergens according to perceptions of the hazards and risks posed to human health. One manifestation thereof is recent listing of certain respiratory allergens as Substances of Very High Concern (SVHC) under the provisions of REACH (Registration, Evaluation, Authorisati...
Source: Regulatory Toxicology and Pharmacology : RTP - February 14, 2014 Category: Toxicology Authors: Kimber I, Basketter DA Tags: Regul Toxicol Pharmacol Source Type: research
Significant Chemical Burns Associated with Dermal Exposure to Laundry Pod Detergent.
We report a case of significant, isolated dermal injury as a result of dermal exposure to a concentrated laundry detergent pod. Total body surface area partial thickness burns in this case were estimated at approximately 2 % with an additional 4-5 % of total body surface area (TBSA) displaying superficial burns/chemical dermatitis. Health-care providers should be aware of this complication and should perform thorough dermal decontamination in the event of an exposure. Parents should be educated regarding the dangers associated with dermal exposure to laundry pod compounds and the need to secure these items away from chil...
Source: Journal of Medical Toxicology - February 14, 2014 Category: Toxicology Authors: Russell JL, Wiles DA, Kenney B, Spiller HA Tags: J Med Toxicol Source Type: research
Chemical Respiratory Allergy: Reverse Engineering an Adverse Outcome Pathway.
Abstract Allergic sensitisation of the respiratory tract by chemicals is associated with rhinitis and asthma and remains an important occupational health issue. Although less than 80 chemicals have been confirmed as respiratory allergens the adverse health effects can be serious, and in rare instances can be fatal, and there are, in addition, related socioeconomic issues. The challenges that chemical respiratory allergy pose for toxicologists are substantial. No validated methods are available for hazard identification and characterisation, and this is due in large part to the fact that there remains considerable u...
Source: Toxicology - February 14, 2014 Category: Toxicology Authors: Kimber I, Dearman RJ, Basketter DA, Boverhof DR Tags: Toxicology Source Type: research
Arsenic speciation in total contents and bioaccessible fractions in atmospheric particles related to human intakes.
Abstract Speciation of inorganic trivalent arsenicals (iAs(III)), inorganic pentavalent arsenicals (iAs(V)), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA) in total arsenic (As) content and its bioaccessible fractions contained in road dust, household air-conditioning (AC) filter dust and PM2.5 was investigated. Inorganic As, especially iAs(V), was observed as the dominant species. Physiologically based extraction test (PBET), an in-vitro gastrointestinal method, was used to estimate the oral As bioaccessibility in coarse particles and the species present in the oral bioaccessible fraction. A composite...
Source: Environmental Pollution - February 14, 2014 Category: Environmental Health Authors: Huang M, Chen X, Zhao Y, Yu Chan C, Wang W, Wang X, Wong MH Tags: Environ Pollut Source Type: research
Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro.
Abstract RV infections frequently trigger exacerbations of respiratory diseases, such as asthma, yet treatment and intervention options remain limited. Statin drugs are the treatment of choice for dyslipidemia and can also modulate immune cell function. To determine whether statin drugs modify antiviral responses of human monocytic cells, we obtained blood monocytes from donors with allergies and/or asthma and treated the cells with sim prior to challenge with RV. RV-induced secretion of CXCL10 was attenuated significantly, irrespective of RV type (RV-16, -14, or -1A), which corresponded with decreases in IFN-α se...
Source: Journal of Leukocyte Biology - February 14, 2014 Category: Hematology Authors: Wickert LE, Karta MR, Audhya A, Gern JE, Bertics PJ Tags: J Leukoc Biol Source Type: research
Characteristics of patients readmitted to intensive care unit: a nested case-control study.
CONCLUSION. Incomplete resolution of respiratory conditions remained an important reason for potentially preventable intensive care unit readmission. Attention to fluid balance and sputum quantity before intensive care unit discharge might prevent unplanned intensive care unit readmission. PMID: 24531500 [PubMed - as supplied by publisher] (Source: Hong Kong Med J)
Source: Hong Kong Med J - February 14, 2014 Category: Journals (General) Authors: Tam OY, Lam SM, Shum HP, Lau CW, Chan KK, Yan WW Tags: Hong Kong Med J Source Type: research
Am J Physiol Lung Cell Mol Physiol; +17 new citations
17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2014/02/13PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - February 13, 2014 Category: Respiratory Medicine Tags: Report Source Type: research
Obstructive sleep apnea (OSA): A complication of acute infectious mononucleosis infection in a child
Abstract: Independently, obstructive sleep apnea (OSA) and infectious mononucleosis are not uncommon in the pediatric population, but acute onset of OSA, as a respiratory complication in the setting of acute EBV infection is extremely uncommon. Previous reports of this clinical entity are sparse and from nearly two decades ago. Urgent adenotonsillectomy was commonly advocated. This complication may be managed medically with systemic corticosteroids and non-invasive continuous positive airway pressure (CPAP), and a case is presented to highlight an updated management approach to this rarely encountered clinical problem in c...
Source: International Journal of Pediatric Otorhinolaryngology - February 13, 2014 Category: ENT & OMF Authors: Jeffrey Cheng Tags: Case reports Source Type: research
Comparative genomics of unintrogressed Campylobacter coli clades 2 and 3
Conclusions: We propose new insights into the evolution of the accessory genome of C. coli clade 3 and C. jejuni. Also, in silico analysis of the gene content revealed that C. coli clades 2 and 3 have genes associated with infection, suggesting they are a potent human pathogen, and may currently be underreported in human infections due to niche separation. (Source: BioMed Central)
Source: BioMed Central - February 13, 2014 Category: Journals (General) Authors: Caroline PA Skarp-de HaanAlejandra CulebroThomas SchottJoana RevezElke KH SchwedaMarja-Liisa HänninenMirko Rossi Source Type: research
Inhaled corticosteroid and children's growth
No one ever died because they fell 1 cm short of their potential final height, but many families understandably worry about the side effects of inhaled corticosteroids (ICS), and may stop ICS treatment in consequence. It is important to state at the outset that reduced linear growth in a child with asthma should not uncritically be attributed to ICS, but should rather lead to a critical re-evaluation of the child. Atopy per se may lead to delay in puberty and a more prolonged prepubertal growth deceleration1; poorly controlled asthma, as with any chronic disease, may lead to growth failure2; and coincidental disease s...
Source: Archives of Disease in Childhood - February 13, 2014 Category: Pediatrics Authors: Bush, A. Tags: Editor's choice, Immunology (including allergy), Reproductive medicine, Child health, Asthma, Drugs: respiratory system Leading article Source Type: research
Diagnosis of cystic fibrosis in London and South East England before and after the introduction of newborn screening
Conclusions NBS has significantly reduced the age of diagnosis, although many were symptomatic even at 3 weeks of age. A small number of patients with CF can still be missed by the screening programme, and the diagnosis should be considered even with a negative screen result. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - February 13, 2014 Category: Pediatrics Authors: Lim, M., Wallis, C., Price, J. F., Carr, S. B., Chavasse, R. J., Shankar, A., Seddon, P., Balfour-Lynn, I. M. Tags: Pancreas and biliary tract, Cystic fibrosis, Screening (epidemiology), Screening (public health) Original article Source Type: research
Clinical and genetic aspects of hypophosphatasia in Japanese patients
Conclusions The most frequent clinical type was the PLH type with prognosis related to respiratory failure, biochemical/radiological changes and ALPL mutations. Cerebral manifestations frequently occurred. Genotype–phenotype correlations were associated with specific outcomes in the PLH type, whereas different clinical features were associated with the same genotype in the non-lethal type. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - February 13, 2014 Category: Pediatrics Authors: Taketani, T., Onigata, K., Kobayashi, H., Mushimoto, Y., Fukuda, S., Yamaguchi, S. Tags: Genetic screening / counselling, Disability, Rheumatology, Ear, nose and throat/otolaryngology, Metabolic disorders Original article Source Type: research
Administering medicines when water is unavailable
In 2007 the World Health Assembly (WHA) passed WHA resolution 60.20 calling for better medicines for children. This step, long overdue, recognised the need for a coordinated approach to improved prescribing for children with special emphasis on those living in remote and low resource settings. Following the adoption of the WHA resolution, rapid progress has been made in the development of an essential medicines list for children (EMLc) now in its fourth edition. A central issue in the ensuing discussions has been a call for the development of easily adaptable child-friendly formulations. It is generally accepted as axiomat...
Source: Archives of Disease in Childhood - February 13, 2014 Category: Pediatrics Authors: MacLeod, S. Tags: Diarrhoea, Epidemiologic studies, ADC Drug Therapy, Drugs: infectious diseases, Otitis, Pneumonia (infectious disease), TB and other respiratory infections, Childhood nutrition, Reproductive medicine, Child health, Infant nutrition (including breastfeedin Source Type: research
Respiratory PCR detects influenza after intranasal live-attenuated influenza vaccination
From 2013 an annual nasal live-attenuated influenza vaccine (LAIV—Fluenz) is available for all children in the UK aged 2 and 3 years and other ‘at-risk’ children, as part of the National Health Service (NHS) childhood vaccination programme.1 2 The vaccine contains reassortant influenza viruses; two influenza A viruses (H1N1 and H3N2) and one influenza B virus,3 and has previously been used in children in the USA. A 2-year-old child presented with respiratory symptoms. PCR assay of nasopharyngeal swab was strongly positive for Rhinovirus (Cycle Threshold, CT 21) and weakly positive for Influenza B (CT...
Source: Archives of Disease in Childhood - February 13, 2014 Category: Pediatrics Authors: Lumley, S., Atkinson, C., Haque, T. Tags: PostScript Source Type: research
Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall
Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for...
Source: Italian Journal of Pediatrics - February 13, 2014 Category: Pediatrics Authors: Massimo ColaneriAndrea QuartiMarco PozziStefano GaspariniInes CarloniFernando Maria de Benedictis Source Type: research
Reviewer acknowledgement 2013
Contributing reviewersThe editors of BMC Pulmonary Medicine would like to thank all our reviewers who have contributed to the journal in Volume 13 (2013). (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 13, 2014 Category: Respiratory Medicine Authors: Catia Cornacchia Source Type: research
Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies
Background: Identifying the predictors of noninvasive ventilation (NIV) failure has attracted significant interest because of the strong link between failure and poor outcomes. However, very little attention has been paid to the timing of the failure. This narrative review focuses on the causes of NIV failure and risk factors and potential remedies for NIV failure, based on the timing factor. Results: The possible causes of immediate failure (within minutes to (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 13, 2014 Category: Respiratory Medicine Authors: Ezgi OzyilmazAylin Ozsancak UgurluStefano Nava Source Type: research
Uncommon aetiologies of chylothorax
Abstract Chylothorax, an uncommon cause of pleural effusion, results from the accumulation of lymph in the pleural space due to damage or obstruction of the thoracic duct. The high content of triglycerides and the presence of chylomicrons set the diagnosis of chylothorax. It's usually secondary to malignancy, trauma, congenital diseases and infections. Less common causes are also described, as the one described in our case‐report. The authors present a patient with chylothorax due to superior vena cava compression or a thoracic aortic aneurysm, discuss the particularities, the investigation of chylothorax as well as its ...
Source: The Clinical Respiratory Journal - February 13, 2014 Category: Respiratory Medicine Authors: Ana Gomes, Sofia Ribeiro, João Neves, Teresa Mendonça Tags: Original Article Source Type: research
Hospital outbreak of Human Respiratory Syncytial Virus (HRSV) illness in immunocompromised hospitalized children during summer
ConclusionsHRSV A outbreak was detected in immunocompromised patients the wider spread of which was prevented by prompt detection and application of preventive measures. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 13, 2014 Category: Respiratory Medicine Authors: Ajay Kr Singh, Bhawana Jain, Anil Kr Verma, Archana Kumar, Tanushree Dangi, Mukesh Dwivedi, Kaleshwar P Singh, Amita Jain Tags: Original Article Source Type: research
Retrieval of various aspirated foreign bodies by flexible cryoprobe: in‐vitro feasibility study
ConclusionFB retrieval by cryoprobe is feasible for many organic and inorganic aspirated objects. However, the cryoadhesive properties of most inorganic FB and several organic objects is unpredictable, hence, if the nature of the FB is known, an identical object should be used to practice the technique of retrieval in vitro, prior to attempting to perform the procedure in the patient. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 13, 2014 Category: Respiratory Medicine Authors: Oren Fruchter, Mordechai R. Kramer Tags: Original Article Source Type: research
Challenges of Antituberculosis Treatment in Patients with Difficult Clinical Conditions
ConclusionsTB can be difficult‐to‐diagnose and treat. This can be especially true in patients with comorbidities, adverse reactions to AT drugs, the elderly and pregnant women. Despite the difficulties, an early diagnosis followed immediately by AT treatment should be the norm for these patients. When choosing a suitable AT regimen we must consider the potential side effects of the drugs, which could exacerbate an underlying comorbidity, harm an expectant mother or fetus, or adversely affect the elderly. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 13, 2014 Category: Respiratory Medicine Authors: Martina Vasakova Tags: Review Article Source Type: research
Contribution of Breathing Frequency and Inhalation Flow Rate on Performance of N95 Filtering Facepiece Respirators
This article reports the development of a procedure to investigate the individual impact of breathing frequency and flow rate on the performance of N95 filtering facepiece respirators. Experiments were performed for two peak inhalation flows (PIFs; 135 and 360 l min–1) and two breathing frequencies [24 and 42 breaths per minute (BPM)] for a total of four cyclic flows (Flow A: 135 l min–1 and 24 BPM; Flow B: 135 l min–1 and 42 BPM; Flow C: 360 l min–1 and 24 BPM; and Flow D: 360 l min–1 and 42 BPM). Each experiment was performed using two different set-ups: the first set-up included both inhala...
Source: Annals of Occupational Hygiene - February 13, 2014 Category: Occupational Health Authors: Mahdavi, A., Bahloul, A., Haghighat, F., Ostiguy, C. Tags: Original Article Source Type: research
Total Inward Leakage Measurement of Particulates for N95 Filtering Facepiece Respirators--A Comparison Study
National Institute for Occupational Safety and Health (NIOSH) certified particulate respirators need to be properly fit tested before use to ensure workers’ respiratory protection. However, the effectiveness of American National Standards Institute-/Occupational Safety and Health Administration (ANSI-/OSHA)-accepted fit tests for particulate respirators in predicting actual workplace protection provided to workers is lacking. NIOSH addressed this issue by evaluating the fit of half-mask particulate filtering respirators as a component of a program designed to add total inward leakage (TIL) requirements for all respir...
Source: Annals of Occupational Hygiene - February 13, 2014 Category: Occupational Health Authors: Rengasamy, S., Walbert, G. F., Newcomb, W. E., Faulkner, K., Rengasamy, M. M., Brannen, J. J., Szalajda, J. V. Tags: Original Article Source Type: research
Physiological Evaluation of Air-Fed Ensembles
The goal of this study was to evaluate the respiratory and metabolic stresses of air-fed ensembles used by workers in the nuclear, chemical, and pharmaceutical industries during rest, low-, and moderate-intensity treadmill exercise. Fourteen men and six women wore two different air-fed ensembles (AFE-1 and AFE-2) and one two-piece supplied-air respirator (SA) at rest (REST) and while walking for 6min at oxygen consumption (V.O2) rates of 1.0 (LOW) and 2.0 l min–1 (MOD). Inhaled CO2 (FICO2), inhaled O2 (FIO2), pressure, and temperature were measured continuously breath-by-breath. For both LOW and MOD, FICO2 was signif...
Source: Annals of Occupational Hygiene - February 13, 2014 Category: Occupational Health Authors: Turner, N. L., Powell, J. B., Sinkule, E. J., Novak, D. A. Tags: Original Article Source Type: research
Highlights from this issue
Ventilation There is a strong respiratory theme in this month's issue. The editor's choice for open access is a meta-analysis of trials of volume – targeted ventilation modes by Peng and colleagues. Evidence from 18 trials enrolling 954 infants is summarised. Compared with pressure – limited ventilation, the use of volume – targeted ventilation modes was associated with a substantial reduction in the risk of air leak, bronchopulmonary dysplasia (BPD), intraventricular haemorrhage and periventricular leukomalacia, There was no effect on mortality. The largest trial included 212 infants and all of the other...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Stenson, B. Tags: Fantoms Source Type: research
Neonatology and obstetric anaesthesia
I could have entitled this Editorial ‘Fissures in perinatal medicine’, because in spite of the rhetoric of physicians taking a unified approach to maternal and infant health, the depressing truth is that in many countries paediatricians, obstetricians, and obstetric anaesthetists inhabit their own academic silos, and all too seldom collaborate constructively in research to improve the lot of mothers and babies. There is at least some historical interplay between obstetrics and neonatology. For instance the neonatal and long term developmental effects of maternal steroid administration has required close collabo...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Ward Platt, M. P. Tags: Obstetrics and gynaecology, Clinical trials (epidemiology), Epidemiologic studies, TB and other respiratory infections, Pain (neurology), Childhood nutrition, Reproductive medicine, Child and adolescent psychiatry (paedatrics), Child health, Infant nutrit Source Type: research
Discussion Congenital epulis is also known as GCT of the newborn, or as Neumann's tumour, after the first published case.1 This tumour is rare and is seen only in the newborn.2 The tumour has a marked female preponderance of 8:1. Several distinguishing features of gingival giant cell tumour includes predilection for newborn females,... (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Sharma, D., Murki, S. Tags: Oncology, Journalology, Pathology, Dentistry and oral medicine, Competing interests (ethics) Images in neonatal medicine Source Type: research
Epidural analgesia in labour and neonatal respiratory distress: a case-control study
Conclusions Late-preterm and term infants exposed to maternal epidural analgesia in labour are more likely to develop respiratory distress in the immediate neonatal period. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Kumar, M., Chandra, S., Ijaz, Z., Senthilselvan, A. Tags: Epidemiologic studies, Pain (neurology), Pain (palliative care), Pain (anaesthesia) Original articles Source Type: research
Human or monitor feedback to improve mask ventilation during simulated neonatal cardiopulmonary resuscitation
Conclusions During simulated neonatal CPR, ECCs did not influence mask leak, and a RFM and verbal feedback were helpful methods to reduce mask leak and increase VT significantly. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Binder, C., Schmolzer, G. M., O'Reilly, M., Schwaberger, B., Urlesberger, B., Pichler, G. Tags: Airway biology, Resuscitation Original articles Source Type: research
Heliox for mechanically ventilated newborns with bronchopulmonary dysplasia
Conclusions Helium–oxygen MV is safe and resulted in improvement of respiratory function and oxygenation in infants with severe BPD requiring MV. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Szczapa, T., Gadzinowski, J., Moczko, J., Merritt, T. A. Tags: Bronchopulmonary dysplasia, Airway biology, Mechanical ventilation Original articles Source Type: research
Patient comfort during treatment with heated humidified high flow nasal cannulae versus nasal continuous positive airway pressure: a randomised cross-over trial
Conclusions Using EDIN scale, we found no difference in patient comfort with HHHFNC versus NCPAP. However, parents preferred HHHFNC, and during HHHFNC respiratory rate was lower than during NCPAP. ClinicalTrials.gov, number NCT01526226. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Klingenberg, C., Pettersen, M., Hansen, E. A., Gustavsen, L. J., Dahl, I. A., Leknessund, A., Kaaresen, P. I., Nordhov, M. Tags: TB and other respiratory infections, Pain (neurology), Child health, Infant health, Neonatal health, Airway biology Original articles Source Type: research
Severe congenital herpes simplex virus infection
Case summary A preterm baby boy was delivered at 29 weeks of gestation following preterm labour. He was ventilated due to poor respiratory effort. His skin was unusually translucent, fragile, red and prominently vascularised. There were sparse pustules and areas of superficial ulceration and sloughing, especially on the face as shown in figure 1. His growth was appropriate for gestational age. Umbilical lines were sited in view of condition of the skin and he was started on parenteral fluids, antibiotics and antiviral therapy immediately following microbiological and virological investigations. Barrier nursing was commence...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Yasmeen, A., Ibhanesebhor, S. E. Tags: Urology, Journalology, Immunology (including allergy), Drugs: infectious diseases, Pregnancy, Reproductive medicine, Child health, Renal medicine, Dermatology, Competing interests (ethics), Metabolic disorders Images in neonatal medicine Source Type: research
Anti-inflammatory actions of endogenous and exogenous interleukin-10 versus glucocorticoids on macrophage functions of the newly born
; D Davidson (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 13, 2014 Category: Perinatology & Neonatology Authors: K KasatH PatelO PredtechenskaI VancurovaD Davidson Tags: dexamethasone betamethasone bronchopulmonary dysplasia cytokines phagocytosis respiratory burst Source Type: research
Functional analysis of the conserved transcriptional regulator CfWor1 in Cladosporium fulvum reveals diverse roles in the virulence of plant pathogenic fungi
Summary Fungal Wor1‐like proteins are conserved transcriptional regulators that are reported to regulate the virulence of several plant pathogenic fungi by affecting the expression of virulence genes. Here, we report the functional analysis of CfWor1, the homologue of Wor1 in Cladosporium fulvum. Δcfwor1 mutants produce sclerotium‐like structures and rough hyphae, which are covered with a black extracellular matrix. These mutants do not sporulate and are no longer virulent on tomato. A CE.CfWor1 transformant that constitutively expresses CfWor1 produces fewer spores with altered morphology and is also reduced in virul...
Source: Molecular Microbiology - February 13, 2014 Category: Microbiology Authors: Bilal Ökmen, Jérôme Collemare, Scott Griffiths, Ate Burgt, Russell Cox, Pierre JGM Wit Tags: Research Article Source Type: research
The Bordetella pertussis Bps polysaccharide enhances lung colonization by conferring protection from complement‐mediated killing
Summary Bordetella pertussis is a human‐restricted Gram‐negative bacterial pathogen that causes whooping cough or pertussis. Pertussis is the leading vaccine preventable disease that is resurging in the USA and other parts of the developed world. There is an incomplete understanding of the mechanisms by which B. pertussis evades killing and clearance by the complement system, a first line of host innate immune defence. The present study examined the role of the Bps polysaccharide to resist complement activity in vitro and in the mouse respiratory tract. The isogenic bps mutant strain containing a large non‐polar in...
Source: Cellular Microbiology - February 13, 2014 Category: Microbiology Authors: Tridib Ganguly, John B. Johnson, Nancy D. Kock, Griffith D. Parks, Rajendar Deora Tags: Research Article Source Type: research
Tablet computers for hospitalized patients: A pilot study to improve inpatient engagement
Inadequate patient engagement in hospital care inhibits high‐quality care and successful transitions to home. Tablet computers may provide opportunities to engage patients, particularly during inactive times between provider visits, tests, and treatments, by providing interactive health education modules as well as access to their personal health record (PHR). We conducted a pilot project to explore inpatient satisfaction with bedside tablets and barriers to usability. Additionally, we evaluated use of these devices to deliver 2 specific Web‐based programs: (1) an interactive video to improve inpatient education about ...
Source: Journal of Hospital Medicine - February 13, 2014 Category: Hospital Management Authors: S. Ryan Greysen, Raman R. Khanna, Ronald Jacolbia, Herman M. Lee, Andrew D. Auerbach Tags: Brief Reports Source Type: research
Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer's disease-relevant murine model
Conclusions: This is the first study to directly examine mitochondrial function in skeletal muscle from an AD-relevant transgenic murine model. As with brain, these deficits in muscle are an early event, occurring prior to appearance of amyloid plaques. (Source: BMC Neuroscience - Latest articles)
Source: BMC Neuroscience - Latest articles - February 13, 2014 Category: Neuroscience Authors: Rosemary SchuhKathryn JacksonAnna SchlappalEspen SpangenburgChristopher WardJi ParkNatalie DuggerGuo Li ShiPaul Fishman Source Type: research
Multidisciplinary Approach to Management of Maternal Asthma (MAMMA): A Randomized Controlled Trial.
CONCLUSION A multidisciplinary model of care for asthma management involving education and regular monitoring could potentially improve maternal asthma outcomes and be widely implemented in clinical practice. CLINICAL TRIAL REGISTRATION: The trial was registered with the Australian and New Zealand Clinical Trial Registry https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12612000681853 ACTRN12612000681853 June 2012. PMID: 24522786 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Lim AS, Stewart K, Abramson MJ, Walker SP, Smith CL, George J Tags: Chest Source Type: research
Variation in Decisions to Forgo Life-Sustaining Therapies in US Intensive Care Units.
CONCLUSION: Although patient factors explain much of the variability in DFLST practices, there are significant effects of ICU culture and practice that influence end-of-life decision-making. The observation that an ICU's risk-adjusted propensity to withdraw life support is directly associated with its standardized mortality ratio suggests problems with using the latter as a quality measure. PMID: 24522751 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Quill CM, Ratcliffe SJ, Harhay MO, Halpern SD Tags: Chest Source Type: research
Effects of Ivacaftor in cystic fibrosis patients carrying the G551D mutation with severe lung disease.
CONCLUSIONS Ivacaftor was clinically effective in CF patients carrying the G551D mutation with severe pulmonary disease. The reductions in treatment requirements were clinically and statistically significant and have not been described in less severe populations. PMID: 24522694 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Barry PJ, Plant BJ, Nair A, Bicknell S, Simmonds NJ, Bell NJ, Shafi NT, Daniels T, Shelmerdine S, Felton I, Gunaratnam C, Jones AM, Horsley AR Tags: Chest Source Type: research
Clinical Application of the COPD Assessment Test: Longitudinal Data from the CHAIN Cohort.
CONCLUSIONS: One-year longitudinal data shows variability in CAT scores among stable COPD patients, similar to what happened to MMRC that was the best predictor of one-year CAT changes. Further longitudinal studies should confirm the long-term CAT variability and it clinical applicability. PMID: 24522636 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: de-Torres JP, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Calle-Rubio M, Solanes-García I, Balbin RA, de Diego-Damia A, Feu-Collado N, Michavila IA, Irigaray R, Balcells E, Casanovas AL, Galdiz Iturri JB, Roy Tags: Chest Source Type: research
Smoking cessation in COPD causes a transient improvement in spirometry and decreases micronodules on HRCT.
Abstract BACKGROUND: Smoking cessation is of major importance for all smokers: however, in patients with COPD there is little information on how this influences lung function and HRCT appearances. METHODS: In this single centre study we performed screening spirometry in a group of heavy smokers aged 40 to 80 years (n=358). We then studied the effects of smoking cessation in 2 groups of selected subjects: smokers with COPD (n=38) and smokers with normal spirometry (n=55). In parallel, to subjects undergoing smoking cessation we studied a control group of non-smokers (n=19). FINDINGS: Patients with COPD who q...
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Dhariwal J, Tennant RC, Hansell DM, Westwick J, Walker C, Ward SP, Pride N, Barnes PJ, Kon OM, Hansel TT Tags: Chest Source Type: research
Determinants of Gait Speed in Chronic Obstructive Lung Disease.
CONCLUSION: Gait speed is more indicative of exercise capacity (6MWT) than daily physical activity in COPD. Despite its simplicity, gait speed has outstanding screening properties for detecting poor and very poor 6MWT performance; making it a useful and informative tool for clinical care of patients with COPD. PMID: 24522522 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Karpman C, Depew ZS, Lebrasseur NK, Novotny PJ, Benzo RP Tags: Chest Source Type: research
Left Atrial Size, Chemosensitivity, and Central Sleep Apnea in Heart Failure.
CONCLUSIONS: Increased LAVI is associated with heightened CO2 chemosensitivity and greater frequency of CSA. LAVI may be useful to guide referral for PSG for detection of CSA in HF patients. PMID: 24522490 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 13, 2014 Category: Respiratory Medicine Authors: Calvin AD, Somers VK, Johnson BD, Scott CG, Olson LJ Tags: Chest Source Type: research
Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database
Conclusions Patients receiving high-dose methylprednisolone had a significantly increased risk of major complications, in particular, gastrointestinal ulcer/bleeding. However, high-dose methylprednisolone treatment was not associated with any increase in mortality. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - February 13, 2014 Category: Emergency Medicine Authors: Chikuda, H., Yasunaga, H., Takeshita, K., Horiguchi, H., Kawaguchi, H., Ohe, K., Fushimi, K., Tanaka, S. Tags: Spinal cord injury, Open access, Pneumonia (infectious disease), TB and other respiratory infections, Urinary tract infections, Coma and raised intracranial pressure, Spinal cord, Trauma CNS / PNS, Venous thromboembolism, Pneumonia (respiratory medicine), Source Type: research