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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.
Abstract Evidence indicates that Parkinson's disease (PD), in addition to having a genetic aetiology, has an environmental component that contributes to disease onset and progression. The exact nature of any environmental agent contributing to PD is unknown in most cases. Given its similarity to paraquat, an agrochemical removed from registration in the EU for its suspected potential to cause PD, we have investigated the in vitro capacity of the related herbicide Diquat to cause PD-like cell death. Diquat showed greater toxicity towards SH-SY5Y neuroblastoma cells and human midbrain neural cells than paraquat and a...
Source: Archives of Toxicology - February 19, 2015 Category: Toxicology Authors: Nisar R, Hanson PS, He L, Taylor RW, Blain PG, Morris CM Tags: Arch Toxicol Source Type: research

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.
We report that the AMPK activator PT-1 selectively increased the activity of γ1- but not γ3-containing complexes in incubated mouse muscle. PT-1 increased the AMPK-dependent phosphorylation of the autophagy-regulating kinase ULK1 on Ser555, but not proposed AMPK-γ3 substrates such as Ser231 on TBC1D1 or Ser212 on ACC2, nor did it stimulate glucose transport. Surprisingly, however, in HEK-293 cells expressing human γ1, γ2 or γ3, PT-1 activated all three complexes equally. We were unable to reproduce previous findings suggesting that PT-1 activates AMPK by direct binding between the kinase and auto-inhibitory domains o...
Source: The Biochemical Journal - February 19, 2015 Category: Biochemistry Authors: Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA Tags: Biochem J Source Type: research

Regulation of High glucose-mediated mucin expression by matrix metalloproteinase-9 in Human airway epithelial cells.
Abstract Mucus hypersecretion is the key manifestation in patients with chronic inflammatory airway diseases and mucin 5AC (MUC5AC) is a major component of airway mucus. Matrix metalloproteinases (MMP)-9, have been found to be involved in the pathogenesis of inflammatory airway diseases. Hyperglycemia has been shown to be an independent risk factor for respiratory infections. We hypothesize that high glucose (HG)-regulates MMP-9 production and MMP-9 activity through nicotinamide adenine dinucleotide phosphate (NADPH)/ reactive oxygen species (ROS) cascades pathways, leading to mucin production in human airway epith...
Source: Experimental Cell Research - February 19, 2015 Category: Cytology Authors: Yu H, Yang J, Xiao Q, Lü Y, Zhou X, Xia L, Nie D Tags: Exp Cell Res Source Type: research

Global Multilocus Sequence Typing Analysis of Mycoplasma bovis Isolates Reveals Two Main Population Clusters [Clinical Veterinary Microbiology]
Mycoplasma bovis is a major bovine pathogen associated with bovine respiratory disease complex and is responsible for substantial economic losses worldwide. M. bovis is also associated with other clinical presentations in cattle, including mastitis, otitis, arthritis, and reproductive disorders. To gain a better understanding of the genetic diversity of this pathogen, a multilocus sequence typing (MLST) scheme was developed and applied to the characterization of 137 M. bovis isolates from diverse geographical origins, obtained from healthy or clinically infected cattle. After in silico analysis, a final set of 7 housekeepi...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Rosales, R. S., Churchward, C. P., Schnee, C., Sachse, K., Lysnyansky, I., Catania, S., Iob, L., Ayling, R. D., Nicholas, R. A. J. Tags: Clinical Veterinary Microbiology Source Type: research

Pyogranulomatous Pneumonia in Goats Caused by an Undescribed Porphyromonas Species, "Porphyromonas katsikii" [Clinical Veterinary Microbiology]
A yet-undescribed bacterial species, tentatively named "Porphyromonas katsikii," was isolated from individuals of a small goat herd with pyogranulomatous pneumonia during an outbreak of acute respiratory disease. The isolated bacteria grew in the form of black-pigmented colonies after 14 days of incubation under anaerobic conditions at 37°C on a tryptic soy blood agar medium. The bacteria were identified as a yet-undescribed Porphyromonas species by determination of the nucleotide sequence of the rrs 16S rRNA gene, and this species was tentatively named Porphyromonas katsikii. PCR amplification with specific primers fo...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Filioussis, G., Petridou, E., Karavanis, E., Frey, J. Tags: Clinical Veterinary Microbiology Source Type: research

Isolation and Characterization of Influenza C Viruses in the Philippines and Japan [Virology]
From November 2009 to December 2013 in the Philippines, 15 influenza C viruses were isolated, using MDCK cells, from specimens obtained from children with severe pneumonia and influenza-like illness (ILI). This is the first report of influenza C virus isolation in the Philippines. In addition, from January 2008 to December 2013, 7 influenza C viruses were isolated from specimens that were obtained from children with acute respiratory illness (ARI) in Sendai city, Japan. Antigenic analysis with monoclonal antibodies to the hemagglutinin-esterase (HE) glycoprotein showed that 19 strains (12 from the Philippines and 7 from Ja...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Odagiri, T., Matsuzaki, Y., Okamoto, M., Suzuki, A., Saito, M., Tamaki, R., Lupisan, S. P., Sombrero, L. T., Hongo, S., Oshitani, H. Tags: Virology Source Type: research

Comparison of the Genedia MTB Detection Kit and the Cobas TaqMan MTB Assay for Detection of Mycobacterium tuberculosis in Respiratory Specimens [Mycobacteriology and Aerobic Actinomycetes]
The performance of the Genedia MTB detection kit was compared with that of the Cobas TaqMan MTB test using respiratory specimens. The Genedia and Cobas assays showed comparable sensitivities (81.8% and 78.8%, respectively) and specificities (99.8% and 99.5%, respectively), while the Genedia assay produced fewer invalid results and required less turnaround time and labor. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Huh, H. J., Kwon, H. J., Ki, C.-S., Lee, N. Y. Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research

Molecular Epidemiology of Enterovirus D68 from 2013 to 2014 in Philippines [Virology]
Enterovirus D68 (EV-D68) has been recognized as an important cause of acute respiratory infections. Here we report the molecular epidemiology of EV-D68 in Philippines from 2013 to 2014; we found cases in areas affected by Typhoon Haiyan and found new strains in the country. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Furuse, Y., Chaimongkol, N., Okamoto, M., Imamura, T., Saito, M., Tamaki, R., Saito, M., Tohoku-RITM Collaborative Research Team, Lupisan, S. P., Oshitani, H. Tags: Virology Source Type: research

Assessment of Metabolic Flexibility of Old and Adult Mice Using Three Noninvasive, Indirect Calorimetry-Based Treatments
In conclusion, InCa analysis of the response to OxR in mice is a sensitive and reproducible treatment to noninvasively measure age-impaired metabolic health. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - February 19, 2015 Category: Geriatrics Authors: Duivenvoorde, L. P. M., van Schothorst, E. M., Swarts, H. J. M., Keijer, J. Tags: Original Article Source Type: research

Peripherally Inserted Central Catheters Complicated by Vascular Erosion in Neonates.
Abstract Peripherally inserted central catheters (PICCs) are widely used in the pediatric population, and their use continues to grow in popularity. These catheters provide a reliable source of venous access to neonatal patients but can also be the cause of life-threatening complications. There are several well-documented complications such as infections, catheter thrombosis, vascular extravasations, and fractured catheters. However, the complication of vascular erosion into the pleural space using both small and silicone-based catheters is rarely described. After obtaining institutional review board approval, we i...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - February 19, 2015 Category: Nutrition Authors: Blackwood BP, Farrow KN, Kim S, Hunter CJ Tags: JPEN J Parenter Enteral Nutr Source Type: research

Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report
Conclusions In this case report we describe the rapid appearance of extramedullary plasmacytomas in the background of an asymptomatic multiple myeloma. An immunohistochemical analysis was negative for CD56 and showed high MIB-1 expression in the extramedullary plasmacytoma and low MIB-1 expression in the bone marrow, contributing to the potential underlying pathophysiology of the recurrent extramedullary plasmacytomas and their genetic changes. Systemic chemotherapy was started and no fourth extramedullary plasmacytoma has developed since. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 19, 2015 Category: Journals (General) Source Type: research

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome
New England Journal of Medicine, Volume 372, Issue 8, Page 747-755, February 2015. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - February 18, 2015 Category: Internal Medicine Tags: article Source Type: research

Driving Pressure and Respiratory Mechanics in ARDS
New England Journal of Medicine, Volume 372, Issue 8, Page 776-777, February 2015. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - February 18, 2015 Category: Internal Medicine Tags: article Source Type: research

One-Year Safety of Olodaterol Once Daily via Respimat® in Patients with GOLD 2–4 Chronic Obstructive Pulmonary Disease: Results of a Pre-Specified Pooled Analysis
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Professor Heinrich W. Herzog (1920-2014)
Respiration (Source: Respiration)
Source: Respiration - February 18, 2015 Category: Respiratory Medicine Source Type: research

A prospective 10-year follow-up polygraphic study of patients treated with a mandibular protruding device
Conclusions MPD treatment is well tolerated and effective in a long-term, 10-year perspective. Weight gain may jeopardize MPD effects. Both patients and relatives reported significantly less snoring and fewer periods of apnea. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Utility of extended cardiac monitoring to detect atrial fibrillation in patients with severe obstructive sleep apnea
Conclusion In patients with severe OSA without a known history of AF, 7 days of extended cardiac monitoring with an ECG event recorder did not detect clinically meaningful, silent AF. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Changes of visual field and optic nerve fiber layer in patients with OSAS
Conclusions OSAS had a high prevalence of POAG. Visual field was damaged and the RNFL was thinned. Due to diverse CSFP, RNFL changed differently in the patients with severe OSAS. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Association between nocturnal hypoxia and liver injury in the setting of nonalcoholic fatty liver disease
Conclusions OSA-related hypoxia was independently associated with the biochemical evidence of liver injury in the presence of NAFLD. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Nasal insufflation treatment adherence in obstructive sleep apnea
Conclusions This study showed similar adherence to NI and CPAP over a short period of usage. A randomized clinical trial is now essential for determining the comparative effectiveness of NI therapy in relation to treatment with CPAP. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Hypoxia: a consequence of obesity and also a tool to treat excessive weight loss
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

The effect of obstructive sleep apnea syndrome and snoring severity to intima-media thickening of carotid artery
Conclusion Carotid artery IMT, which is an early finding of atherosclerosis, was found to be highly correlated with OSAS and snoring severity. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Swallowing and breathing patterns during sleep in patients with obstructive sleep apnea
Conclusions Swallowing frequency during sleep can increase with increasing OSA severity in most OSA patients. These events are predominately associated with respiratory event-related arousals and are more frequent when preceded by oronasal breathing. The observed swallowing under high ventilatory needs may compromise the maintenance of the pharynx as a conduit for airflow in OSA patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Oropharyngeal exercises to reduce symptoms of OSA after AT
Conclusions Oropharyngeal exercises may be considered as complementary therapy to adenotonsillectomy to effectively treat pediatric OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Author response to: Endothelial function is not always well preserved in obese patients with mild OSA
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Author response to: hypoxia a consequence of obesity and also a tool to treat excessive weight loss
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Response to letter on “Validation study on sleep parameters by actigraphy for normal subjects”
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Should you screen all your sleep apnea patients for thyroid disease?
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Endothelial function is not always well preserved in obese patients with mild OSA
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Erratum to: Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

The influence of nasal abnormalities in adherence to continuous positive airway pressure device therapy in obstructive sleep apnea patients. What role does the nose play?
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Diagnosis and treatment of snoring in adults—S2k guideline of the German Society of Otorhinolaryngology, Head and Neck Surgery
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Validation study on sleep parameters by actigraphy for normal subjects
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Enterovirus D68–Associated Acute Respiratory Distress Syndrome in Adult, United States, 2014
J. J. Farrell et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - February 18, 2015 Category: Infectious Diseases Source Type: research

Intensive Care Unit Admission Rates for Respiratory Syncytial Virus Infection as a Function of Age in Preterm Infants Born at 32–35-week Gestation and Not Receiving Immunoprophylaxis
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - February 18, 2015 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Detection of Vaccine-derived Rotavirus Strains in Nonimmunocompromised Children up to 3–6 Months After RotaTeq® Vaccination
We conducted a survey on the presence of RotaTeq vaccine viruses in infants hospitalized with respiratory infection, and detected shedding in 17% of children ( (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - February 18, 2015 Category: Infectious Diseases Tags: Vaccine Reports Source Type: research

Infantile Hemophagocytic Lymphohistiocytosis in a Case of Chediak-Higashi Syndrome Caused by a Mutation in the LYST/CHS1 Gene Presenting With Delayed Umbilical Cord Detachment and Diarrhea
A 2-month-old female infant, born to consanguineous parents, presented with infections in skin and upper respiratory tract. She was notable for delayed umbilical cord detachment, partial albinism, and neurological irritability. Giant granules were present in white blood cells. The intracellular perforin content in CD8+ T cells seems to correlate to the immune activation state of the patient with 82% and 8% perforin-containing CD8+ T cells at active and nonactive hemophagocytic lymphohistiocytosis (HLH) disease, respectively. HLH was confirmed by hemophagocytosis in bone marrow and absent natural killer cell activity. The p...
Source: Journal of Pediatric Hematology Oncology - February 18, 2015 Category: Hematology Tags: Online Articles: Original Articles Source Type: research

Immune targeting of the pleural space by intercostal approach
Conclusion: As the importance for in-depth knowledge of participating immune cells during health and disease evolves, the presented technique opens new possibilities to experimentally elucidate immune cell function, trafficking and contribution of pleural space cells during airway diseases. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 18, 2015 Category: Respiratory Medicine Authors: Georg Weber Source Type: research

IL-27 alleviates the bleomycin-induced pulmonary fibrosis by regulating the Th17 cell differentiation
Conclusions: This study demonstrates that IL-27 potentially attenuates BLM-induced pulmonary fibrosis by regulating Th17 differentiation and cytokine secretion. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - February 18, 2015 Category: Respiratory Medicine Authors: Zhaoxing DongXin LuYanni YangTao ZhangYongxia LiYanlin ChaiWen LeiChangbo LiLi AiWenlin Tai Source Type: research

Evaluation of serum interleukin-1 beta as an inflammatory marker in COPD patients
Conclusions IL-1β correlated with clinical aspects of disease severity, suggesting that IL-1β may play a critical role in COPD. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - February 18, 2015 Category: Respiratory Medicine Source Type: research

Evaluating the impact of high‐ and low‐fidelity instruction in the development of auscultation skills
ConclusionsThe results from this study suggest that highly contextualised learning environments may not be uniformly advantageous for instruction and may lead to ineffective learning by increasing extraneous cognitive load in novice learners. (Source: Medical Education)
Source: Medical Education - February 18, 2015 Category: Universities & Medical Training Authors: Ruth Chen, Lawrence E Grierson, Geoffrey R Norman Tags: Simulation‐based Learning Source Type: research

A Rolling Circle Replication Mechanism Produces Multimeric Lariats of Mitochondrial DNA in Caenorhabditis elegans
by Samantha C. Lewis, Priit Joers, Smaranda Willcox, Jack D. Griffith, Howard T. Jacobs, Bradley C. Hyman Mitochondrial DNA (mtDNA) encodes respiratory complex subunits essential to almost all eukaryotes; hence respiratory competence requires faithful duplication of this molecule. However, the mechanism(s) of its synthesis remain hotly debated. Here we have developed Caenorhabditis elegans as a convenient animal model for the study of metazoan mtDNA synthesis. We demonstrate that C. elegans mtDNA replicates exclusively by a phage-like mechanism, in which multimeric molecules are synthesized from a circular template. In co...
Source: PLoS Genetics - February 18, 2015 Category: Genetics & Stem Cells Authors: Samantha C. Lewis et al. Source Type: research

Assessment of patient-ventilator breath contribution during Neurally Adjusted Ventilatory Assist in patients with acute respiratory failure
IntroductionWe previously showed in animals that the ratio of inspired tidal volume (Vtinsp) to inspiratory peak diaphragm electrical activity (EAdipk) can be used to quantify the respective patient and ventilator breath contributions (PVBC) during Neurally Adjusted Ventilatory Assist (NAVA). The PVBC index has not been tested clinically. Methods: We studied 12 intubated and mechanically ventilated patients with acute respiratory failure, and measured EAdipk, airway (Paw) and inspiratory esophageal pressure (Pes), and Vtinsp. We applied 11 different NAVA levels, increasing every 3 minutes in steps of 0.3 cm H2O/μV from ...
Source: Critical Care - February 18, 2015 Category: Intensive Care Authors: Ling LiuSongqiao LiuJianfeng XieYi YangArthur SlutskyJennifer BeckChrister SinderbyHaibo Qiu Source Type: research

Failure of high-flow nasal cannula therapy may delay intubation and increase mortality
Conclusions Failure of HFNC might cause delayed intubation and worse clinical outcomes in patients with respiratory failure. Large prospective and randomized controlled studies on HFNC failure are needed to draw a definitive conclusion. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - February 18, 2015 Category: Intensive Care Source Type: research

Temperature acclimation of mitochondria function from the hearts of a temperate wrasse (Notolabrus celidotus)
Publication date: June 2015 Source:Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Volume 184 Author(s): F.I. Iftikar , A.J. Morash , D.G. Cook , N.A. Herbert , A.J.R. Hickey Understanding how mitochondrial function alters with acclimation may provide insight to the limits these organelles place on temperate fish hearts facing seasonal temperature fluctuations. This investigation determined if compromised cardiac mitochondrial function contributed to heart failure (HF) in the New Zealand wrasse Notolabrus celidotus acclimated at their mean summer and winter ocean temperatures. ...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - February 18, 2015 Category: Biochemistry Source Type: research

Complement evasion by Bordetella pertussis : implications for improving current vaccines
Abstract Bordetella pertussis causes whooping cough or pertussis, a highly contagious disease of the respiratory tract. Despite high vaccination coverage, reported cases of pertussis are rising worldwide and it has become clear that the current vaccines must be improved. In addition to the well-known protective role of antibodies and T cells during B. pertussis infection, innate immune responses such as the complement system play an essential role in B. pertussis killing. In order to evade this complement activation and colonize the human host, B. pertussis expresses several molecules that inhibit compl...
Source: Journal of Molecular Medicine - February 18, 2015 Category: Molecular Biology Source Type: research

Direct multiplexed whole genome sequencing of respiratory tract samples reveals full viral genomic information
Acute respiratory tract infections (RTI) are a major cause of hospitalization of children below 5 years of age [1]. Respiratory tract infections in these young children are associated with high morbidity and mortality [2]. Over 65% of respiratory infections are caused by viruses [3]. In the last decades, improvement of molecular techniques has resulted in the discovery of new viruses. However, the viral etiology of RTI is still unknown in a significant number of cases [3]. Current diagnostic methods for virus detection are mainly based on molecular amplification techniques such as PCR, using large panels of the currently k...
Source: Journal of Clinical Virology - February 18, 2015 Category: Virology Authors: Jan Zoll, Janette Rahamat-Langendoen, Inge Ahout, Marien I.de Jonge, Jop Jans, Martijn A. Huijnen, Gerben Ferwerda, Adilia Warris, Willem J.G. Melchers Source Type: research