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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

Quality of life in relation to the traffic pollution indicators NO2 and NOx: results from the Swedish GA(2)LEN survey.
CONCLUSIONS: At moderate exposure levels traffic pollution appears not to affect quality of life. PMID: 25478186 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Sommar JN, Ek A, Middelveld R, Bjerg A, Dahlén SE, Janson C, Forsberg B Tags: BMJ Open Respir Res Source Type: research

Improvement of CRB-65 as a prognostic tool in adult patients with community-acquired pneumonia.
CONCLUSIONS: Modification of CRB-65 by including hypoxaemia and presence of specified underlying diseases increased the scoring system's prognostic accuracy while retaining its independence of laboratory tests. DS CRB-65 may have the potential to further facilitate site of care decision for patients with CAP. PMID: 25478185 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Dwyer R, Hedlund J, Henriques-Normark B, Kalin M Tags: BMJ Open Respir Res Source Type: research

The impact of chronic obstructive pulmonary disease on intensive care unit admission and 30-day mortality in patients undergoing colorectal cancer surgery: a Danish population-based cohort study.
CONCLUSIONS: COPD is a strong predictor for intensive care unit admission and mortality after CRC surgery. PMID: 25478184 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Platon AM, Erichsen R, Christiansen CF, Andersen LK, Sværke C, Montomoli J, Sørensen HT Tags: BMJ Open Respir Res Source Type: research

Identifying the challenges and facilitators of implementing a COPD care bundle.
CONCLUSIONS: Maximising the impact of a care bundle relies on its successful and timely implementation. Teams implementing the COPD care bundle encountered challenges that were common to all teams and sites. Understanding and learning from the challenges faced by previous endeavours and identifying the facilitators to overcoming these barriers provides an opportunity to mitigate issues that waste time and resources, and ensures that training can be tailored to the anticipated challenges. PMID: 25478183 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Lennox L, Green S, Howe C, Musgrave H, Bell D, Elkin S Tags: BMJ Open Respir Res Source Type: research

Feasibility of using an epigenetic marker of risk for lung cancer, methylation of p16, to promote smoking cessation among US veterans.
CONCLUSIONS: Testing for an epigenetic marker of lung cancer risk is accepted and understood by active smokers. A low-risk test result does not decrease motivation to stop smoking. TRIAL REGISTRATION NUMBER: NCT01038492. PMID: 25478181 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Shofer S, Beyea M, Li S, Bastian LA, Wahidi MM, Kelley M, Lipkus IM Tags: BMJ Open Respir Res Source Type: research

An observational cohort study to determine efficacy, adherence and outcome of the early initiation of pressure support ventilation during mechanical ventilation.
CONCLUSIONS: Physician-led transition to PSV and weaning was often initiated early and successfully before patients fulfilled conventional screening criteria. Failure to sustain a PSV trial could be an early indicator of prolonged MV and ICU mortality and warrants further investigation. These data support the view that current screening criteria may delay initiation of weaning. PMID: 25478179 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Glover G, Connolly B, Di Gangi S, Ayers L, Terblanche M, Beale R, Hart N Tags: BMJ Open Respir Res Source Type: research

Cross-Atlantic modification and validation of the A Tool to Assess Quality of Life in Idiopathic Pulmonary Fibrosis (ATAQ-IPF-cA).
CONCLUSIONS: The reliability and validity of the substantially shortened ATAQ-IPF-cA are acceptable and comparable to the original instrument. We recommend use of the ATAQ-IPF-cA in IPF studies in which participants are enrolled from the USA and UK. PMID: 25478176 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Yorke J, Spencer LG, Duck A, Ratcliffe S, Kwong GN, Longshaw MS, Belkin A, Swigris JJ Tags: BMJ Open Respir Res Source Type: research

A cohort study to identify simple clinical tests for chronic respiratory failure in obese patients with sleep-disordered breathing.
CONCLUSIONS: The measurement of FVC and clinic SpO2 in obese patients with abnormal overnight limited respiratory studies predicted hypercapnia. This may have clinical utility in stratifying patients attending sleep clinics. PMID: 25478174 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Mandal S, Suh ES, Boleat E, Asher W, Kamalanathan M, Lee K, Douiri A, Murphy PB, Steier J, Hart N Tags: BMJ Open Respir Res Source Type: research

Using a non-invasive assessment of lung injury in a murine model of acute lung injury.
Abstract Arterial oxygen saturation has not been assessed sequentially in conscious mice as a direct consequence of an in vivo murine model of acute lung injury. Here, we report daily changes in arterial oxygen saturation and other cardiopulmonary parameters by using infrared pulse oximetry following intratracheal lipopolysaccharide (IT-LPS) for up to 9 days, and following IT-phosphate buffered saline up to 72 h as a control. We show that arterial oxygen saturation decreases, with maximal decline at 96 h post IT-LPS. Blood oxygen levels negatively correlate with 7 of 10 quantitative markers of murine lung inj...
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Lax S, Wilson MR, Takata M, Thickett DR Tags: BMJ Open Respir Res Source Type: research

Investigating significant health trends in idiopathic pulmonary fibrosis (INSIGHTS-IPF): rationale, aims and design of a nationwide prospective registry.
DISCUSSION: INSIGHTS-IPF documents one of the largest IPF cohorts in Europe. The registry is expected to provide much-needed data on the characteristics and management situation of patients with IPF in Germany. It will allow comparisons with other countries. Gap analyses based on current guidelines for management of these patients will be possible. PMID: 25478169 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Behr J, Hoeper MM, Kreuter M, Klotsche J, Wirtz H, Pittrow D Tags: BMJ Open Respir Res Source Type: research

The AIMAR recommendations for early diagnosis of chronic obstructive respiratory disease based on the WHO/GARD model*
Abstract Respiratory diseases in Italy already now represent an emergency (they are the 3(rd) ranking cause of death in the world, and the 2(nd) if Lung cancer is included). In countries similar to our own, they result as the principal cause for a visit to the general practitioner (GP) and the second main cause after injury for recourse to Emergency Care. Their frequency is probably higher than estimated (given that respiratory diseases are currently underdiagnosed). The trend is towards a further increase due to epidemiologic and demographic factors (foremost amongst which are the widespread diffusion of cigarette...
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Nardini S, Annesi-Maesano I, Donno MD, Delucchi M, Bettoncelli G, Lamberti V, Patera C, Polverino M, Russo A, Santoriello C, Soverina P Tags: Multidiscip Respir Med Source Type: research

Sedation and weaning from mechanical ventilation: time for 'best practice' to catch up with new realities?
Abstract Delivery of sedation in anticipation of weaning of adult patients from prolonged mechanical ventilation is an arena of critical care medicine where opinion-based practice is currently hard to avoid because robust evidence is lacking. We offer some views on this subject, hoping to stimulate debate among colleagues. PMID: 25473522 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - December 9, 2014 Category: Respiratory Medicine Authors: Conti G, Mantz J, Longrois D, Tonner P Tags: Multidiscip Respir Med Source Type: research

The Institute of Circulatory and Respiratory Health Strategic Plan for 2013-2016 Executive Summary
Publication date: December 2014 Source:Canadian Journal of Cardiology, Volume 30, Issue 12 Author(s): Jean L. Rouleau , Pierre Boyle , Ilana K. Gombos , Jennifer L. Ralph , Lindsay D. Jacobi Cadete , Maryse Desjardins , Caroline Wong (Source: Canadian Journal of Cardiology)
Source: Canadian Journal of Cardiology - December 9, 2014 Category: Cardiology Source Type: research

Respiratory drugs prescribed off-label among children in the outpatient clinics of a hospital in Malaysia
Conclusion There was substantial prescribing of respiratory drugs for children in an off-label manner at the outpatient clinics at the Universiti Kebangsaan Malaysia Medical Centre. This highlights the need for more research to be carried out on respiratory drugs in the pediatric population. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - December 9, 2014 Category: Drugs & Pharmacology Source Type: research

Systemic Combined Melatonin‐Mitochondria Treatment Improves Acute Respiratory Distress Syndrome in the Rat
In conclusion, combined melatonin‐mitochondrial was superior to either treatment alone in attenuating ARDS in this rat model. This article is protected by copyright. All rights reserved. (Source: Journal of Pineal Research)
Source: Journal of Pineal Research - December 9, 2014 Category: Research Authors: Cheuk‐Kwan Sun, Fan‐Yen Lee, Ying‐Hsien Kao, Hsin‐Ju Chiang, Pei‐Hsun Sung, Tzu‐Hsien Tsai, Yu‐Chun Lin, Steve Leu, Ying‐Chung Wu, Hung‐I Lu, Yung‐Lung Chen, Sheng‐Ying Chung, Hong‐Lin Su, Hon‐Kan Yip Tags: Original Article Source Type: research

MALDI-TOF mass spectrometry and identification of new bacteria species in air samples from Makkah, Saudi Arabia
Conclusions: During the Hajj, the air was contaminated by many environmental bacterial agents, and MALDI-TOF MS was successfully adapted for their rapid identification. (Source: BMC Research Notes)
Source: BMC Research Notes - December 9, 2014 Category: Research Authors: Emmanouil AngelakisMuhammad YasirEsam AzharAnastasia PapadiotiFehmida BibiAsad AburizaizaSarah MetidjiZiad MemishAhmad AshshiAhmed HassanSteve HarakehPhilippe GautretDidier Raoult Source Type: research

Vitamin D binding protein genotype variants and risk of chronic obstructive pulmonary disease: A meta‐analysis
ConclusionThe GC‐1F allele of the vitaminD binding protein was a risk for COPD in recessive mode. (Source: Respirology)
Source: Respirology - December 9, 2014 Category: Respiratory Medicine Authors: Nobuyuki Horita, Naoki Miyazawa, Koji Tomaru, Miyo Inoue, Yoshiaki Ishigatsubo, Takeshi Kaneko Tags: Review Source Type: research

Hydroxychloroquine in children with interstitial (diffuse parenchymal) lung diseases
Summary Hydroxychloroquine (HCQ) is one of the drugs frequently used for the treatment of interstitial lung disease (ILD) in children (chILD). This use is off‐label and studies to analyze the effect and safety of HCQ in chILD are lacking. Therefore, a literature research on the usage of chloroquine (CQ) and HCQ in these conditions was done.Eighty‐five case reports and small series in the period from 1984 to 2013 were identified in which children with different diagnoses of ILD were treated with CQ or HCQ, sometimes in combination with other medication including steroids. A favorable response to HCQ or CQ was reported i...
Source: Pediatric Pulmonology - December 9, 2014 Category: Respiratory Medicine Authors: Sarah Braun, Marion Ferner, Kai Kronfeld, Matthias Griese Tags: Review Source Type: research

Prognostic role of serum uric acid in acute respiratory distress syndrome patients: A preliminary study
Conclusion Serum uric acid level at 8.4mg/dl cut off point predicts mortality in ARDS patients with 89% sensitivity and 80% specificity. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - December 9, 2014 Category: Respiratory Medicine Source Type: research

Tension Chylothorax Following Pneumonectomy
Publication date: Available online 9 December 2014 Source:Respiratory Medicine Case Reports Author(s): Hemang Yadav , Matthew E. Nolan , Francis C. Nichols III , Craig E. Daniels Post-pneumonectomy chylothorax is an uncommon complication following surgery, with an estimated incidence of less than 0.7%. Post-pneumonectomy tension chylothorax, where rapid accumulation of chyle in the post-pneumonectomy space results in hemodynamic compromise, is exceedingly rare, with just 7 cases previously reported. All prior cases of tension chylothorax were managed operatively with decompressive chest tube placement followed by open th...
Source: Respiratory Medicine Case Reports - December 9, 2014 Category: Respiratory Medicine Source Type: research

Acupuncture points used in the prophylaxis against recurrent uncomplicated cystitis, patterns identified and their possible relationship to physiological measurements
Conclusion Treating Kidney pattern related patients with the combination of BL23 and KI3 resulted in far better outcome than other points/combination of points for other Chinese medicine diagnoses. The acupoint SP6 may be less indicated than previously assumed when treating cystitis-prone women prophylactically. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - December 9, 2014 Category: Internal Medicine Source Type: research

A novel approach to study oxidative stress in neonatal respiratory distress syndrome
Conclusion The study provides convincing evidence of oxidative damage and diminished antioxidant defenses in newborns with RDS. Neonatal RDS is characterized by damage of lipid, protein and DNA which indicates the augmentation of oxidative stress. General significance Identification of potential biomarker of oxidative stress consists of promising strategy to study the pathophysiology of neonatal RDS. (Source: BBA Clinical)
Source: BBA Clinical - December 9, 2014 Category: Biochemistry Source Type: research

NMR structures and localization of the potential fusion peptides and the pre-transmembrane region of SARS-CoV: Implications in membrane fusion
Publication date: February 2015 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1848, Issue 2 Author(s): Mukesh Mahajan , Surajit Bhattacharjya Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) poses a serious public health hazard. The S2 subunit of the S glycoprotein of SARS-CoV carries out fusion between the virus and the host cells. However, the exact mechanism of the cell fusion process is not well understood. Current model suggests that a conformational transition, upon receptor recognition, of the two heptad core regions of S2 may expose the hydrophobic fusogenic peptide or fusio...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - December 9, 2014 Category: Biochemistry Source Type: research

Chronic hypercapnic incubation increases relative organ growth and reduces blood pressure of embryonic American alligator (Alligator mississippiensis)
This study is the first to chronically incubate reptilian eggs in hypercapnia and suggests that high CO2 alters the cardiovascular phenotype of alligator embryos (low blood pressure, relatively enlarged hearts), as well as the relative size of the organs primarily responsible for acid base balance, lungs and kidneys. The lungs and kidneys are largely non-functional during embryonic development, and the embryonic phenotype of increased relative mass may be a predictive-adaptation to metabolic or respiratory acidosis, such as during exercise or high respiratory CO2. This study demonstrates that phenotypic plasticity of allig...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - December 9, 2014 Category: Biochemistry Source Type: research

White-nose syndrome initiates a cascade of physiologic disturbances in the hibernating bat host
Conclusions: Integrating these novel findings on the physiological changes that occur in early-stage WNS with those previously documented in late-stage infections, we propose a multi-stage disease progression model that mechanistically describes the pathologic and physiologic effects underlying mortality of WNS in hibernating bats. This model identifies testable hypotheses for better understanding this disease, knowledge that will be critical for defining effective disease mitigation strategies aimed at reducing morbidity and mortality that results from WNS. (Source: BMC Physiology)
Source: BMC Physiology - December 9, 2014 Category: Physiology Authors: Michelle VerantCarol MeteyerJohn SpeakmanPaul CryanJeffrey LorchDavid Blehert Source Type: research

Influence of advections of particulate matter from biomass combustion on specific-cause mortality in Madrid in the period 2004-2009.
This study sought to evaluate the possible effect of advections of particulate matter from biomass fuel combustion on daily specific-cause mortality among the general population and the segment aged ≥75 years in Madrid. Ecological time-series study in the city of Madrid from January 01, 2004 to December 31, 2009. The dependent variable analysed was daily mortality due to natural (ICD-10:A00-R99), circulatory (ICD-10:I00-I99), and respiratory (ICD-10:J00-J99) causes in the population, both general and aged ≥75 years. The following independent and control variables were considered: a) daily mean PM2.5 and PM10 concentr...
Source: Environmental Science and Pollution Research International - December 9, 2014 Category: Environmental Health Authors: Linares C, Carmona R, Tobías A, Mirón IJ, Díaz J Tags: Environ Sci Pollut Res Int Source Type: research

Correlations between the behavior of recreational horses, the physiological parameters and summer atmospheric conditions
Abstract The aim of this paper was to select atmospheric factors and their values, which may disrupt the correct behavior and physiological condition of recreational horses. The studies were carried out from 1 July until 1 September on 16 Anglo‐Arabian geldings. Each day, from 09.00 to 10.00 hours, the horses worked under saddle. The riders and the authors gave a qualitative behavioral assessment for each horse. Mood and willingness to work were evaluated. The quantitative assessment was called ‘incorrect behavior of the horse while riding’ (IBHR). The percentage time of duration and the number of occurrences of the ...
Source: Animal Science Journal - December 9, 2014 Category: Zoology Authors: Iwona Janczarek, Izabela Wilk, Edyta Zalewska, Krzysztof Bocian Tags: Original Article Source Type: research

Real-time prediction and gating of respiratory motion using an extended Kalman filter and Gaussian process regression.
Abstract Motion-adaptive radiotherapy aims to deliver a conformal dose to the target tumour with minimal normal tissue exposure by compensating for tumour motion in real time. The prediction as well as the gating of respiratory motion have received much attention over the last two decades for reducing the targeting error of the treatment beam due to respiratory motion. In this article, we present a real-time algorithm for predicting and gating respiratory motion that utilizes a model-based and a model-free Bayesian framework by combining them in a cascade structure. The algorithm, named EKF-GPR(+), implements a gat...
Source: Physics in Medicine and Biology - December 9, 2014 Category: Physics Authors: Bukhari W, Hong SM Tags: Phys Med Biol Source Type: research

Chaos to randomness: distinguishing between healthy and non-healthy lung sound behaviour.
Abstract Lung abnormalities and respiratory diseases increase as side effects of urban life and development. Therefore, understanding lung dynamics and its changes during the presence of abnormalities are critical in order to design more reliable tools for the early diagnosis and screening of lung pathology. The goal of this paper is to indicate the chaotic nature of normal lung sound and its transition to randomness in the presence of lung disease. The latter characteristic could serve as an indicator for evaluating the recovery process for patients suffering from lung disease. To verify this idea, we compared gro...
Source: Medical Physics - December 9, 2014 Category: Physics Authors: Jafari Moghadam Fard P, Moradi MH, Saber S Tags: Australas Phys Eng Sci Med Source Type: research

Acute Respiratory Distress Syndrome and Outcomes after Near-hanging
Assess the case rate of Acute Respiratory Distress Syndrome (ARDS) after near-hanging, and the secondary outcomes of traumatic and/or anoxic brain injury, and death. Risk factors for the outcomes were assessed. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 9, 2014 Category: Emergency Medicine Authors: Sahar Mansoor, Majid Afshar, Matthew Barrett, Gordon S. Smith, Erik A. Barr, Matthew E. Lissauer, Michael T. McCurdy, Sarah B. Murthi, Giora Netzer Tags: Original Contribution Source Type: research

Fatal influenza outbreak aboard a sport fishing vessel in San Diego, California
In January 2014, the Centers for Disease Control and Prevention (CDC) was notified about a death aboard a sport fishing vessel on a 16-day cruise off the Baja California peninsula. The male passenger, aged 70 years, had chronic obstructive pulmonary disease, coronary artery disease, was obese, and had not received the seasonal influenza vaccine. He had chills, productive cough, and dyspnea before his death on January 22, 2014. A second passenger, unrelated to the decedent, was medically evacuated on January 24, 2014, while at an international port due to respiratory illness. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - December 9, 2014 Category: Infectious Diseases Authors: Jessica K. Adam, Aiden K. Varan, Annie S. Kao, Eric C. McDonald, Stephen H. Waterman Tags: Correspondence Source Type: research

The effect of obstructive sleep apnea syndrome and continuous positive airway pressure treatment on voice performance.
CONCLUSION: The acoustic parameters of OSAS patients differed from those of the normal control subjects. The patients' voice performance improved after a regular use of CPAP treatment for 1 month. PMID: 25487313 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 9, 2014 Category: Sleep Medicine Authors: Atan D, Ozcan KM, Ikincioğulları A, Köseoğlu S, Cetin MA, Ensari S, Dere H Tags: Sleep Breath Source Type: research

Subjects with COPD and productive cough have an increased risk for exacerbations and death
Chronic bronchitis is related to worse general health status, exacerbations and mortality among subjects with COPD. Also less longstanding cough and phlegm may be related to worse prognosis in COPD but this has rarely been evaluated in population-based studies. 
 (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 9, 2014 Category: Respiratory Medicine Authors: Anne Lindberg, Sami Sawalha, Linnea Hedman, Lars-Gunnar Larsson, Bo Lundbäck, Eva Rönmark Source Type: research

Birt-Hogg-Dubé syndrome. State-of-the-art review with emphasis on pulmonary involvement
Birt-Hogg-Dubé syndrome (BHDS) is a rare, inherited autosomal-dominant disorder characterized by the development of cutaneous lesions, renal tumors, pulmonary cysts, and spontaneous pneumothorax. The gene responsible for BHDS is located on the short arm of chromosome 17 (17p11.2) and codes for the protein folliculin, which is believed to be an oncogene suppressor protein. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 9, 2014 Category: Respiratory Medicine Authors: Aline Amaral Dal Sasso, Luciana Camara Belém, Gláucia Zanetti, Carolina Althoff Souza, Dante Luiz Escuissato, Klaus Loureiro Irion, Marcos Duarte Guimarães, Edson Marchiori Tags: Review Source Type: research