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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

CT staging and monitoring of fibrotic interstitial lung diseases in clinical practice and treatment trials: a Position Paper from the Fleischner society
Publication date: Available online 11 May 2015 Source:The Lancet Respiratory Medicine Author(s): David M Hansell , Jonathan G Goldin , Talmadge E King Jr , David A Lynch , Luca Richeldi , Athol U Wells CT is increasingly being used to stage and quantify the extent of diffuse lung diseases both in clinical practice and in treatment trials. The role of CT in the assessment of patients entering treatment trials has greatly expanded as clinical researchers and pharmaceutical companies have focused their efforts on developing safe and effective drugs for interstitial lung diseases, particularly for idiopathic pulmonary fibros...
Source: The Lancet Respiratory Medicine - May 12, 2015 Category: Respiratory Medicine Source Type: research

Rural-Urban Differences in the Prevalence of Chronic Disease in Northeast China
Rural–urban differences in the prevalence of chronic diseases in the adult population of northeast China are examined. The Jilin Provincial Chronic Disease Survey used personal interviews and physical measures to research the presence of a range of chronic diseases among a large sample of rural and urban provincial residents aged 18 to 79 years (N = 21 435). Logistic regression analyses were used. After adjusting for age and gender, rural residents had higher prevalence of hypertension, chronic ischemic heart disease, cerebrovascular disease, chronic low back pain, arthritis, chronic gastroenteritis/peptic ulcer, chr...
Source: Asia-Pacific Journal of Public Health - May 12, 2015 Category: Global & Universal Authors: Wang, S., Kou, C., Liu, Y., Li, B., Tao, Y., D'Arcy, C., Shi, J., Wu, Y., Liu, J., Zhu, Y., Yu, Y. Tags: Articles Source Type: research

Prevalence and Risk Factors of Respiratory Symptoms Among Home-Based Garment Workers in Bangkok, Thailand
This study aimed to determine the prevalence and risk factors associated with respiratory symptoms. A cross-sectional study with random sampling method was employed and 300 home-based garment workers (HBGWs) were recruited. Risk factors, including personal factors; knowledge, health preventive behaviors, and skill of self-health surveillance, working condition, and respiratory symptoms were assessed. Data were collected using self-reported questionnaires. Prevalence of respiratory symptom was 22.3%. Majority of participants were female (78%). Mean age and working experience were 37.38 years (SD = 10.70) and 13.58 years (SD...
Source: Asia-Pacific Journal of Public Health - May 12, 2015 Category: Global & Universal Authors: Chumchai, P., Silapasuwan, P., Wiwatwongkasem, C., Arphorn, S., Suwan-ampai, P. Tags: Articles Source Type: research

Nematode dermatitis due to Angiostrongylus vasorum infection in a dog.
CONCLUSIONS AND CLINICAL IMPORTANCE: Angiostrongylus vasorum should be considered in dogs presented with skin lesions and respiratory signs. Skin biopsy, chest radiographs and Baermann test should be included in the diagnostic investigation. PMID: 25963239 [PubMed - as supplied by publisher] (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - May 12, 2015 Category: Veterinary Research Authors: Cavana P, Bensignor E, Blot S, Carlus M, Chermette R, Crosaz O, Grimm F, Hurion M, Jeandel A, Polack B Tags: Vet Dermatol Source Type: research

Epigenetic Regulation of Tolerance to TLR Ligands in Alveolar Epithelial Cells.
Abstract In order to protect the host against exuberant inflammation and injury responses, cells have the ability to become hyporesponsive or "tolerized" to repeated stimulation by microbial and non-microbial insults. The lung airspace is constantly exposed to a variety of exogenous and endogenous Toll-like receptor (TLR) ligands, yet the ability of alveolar epithelial cells (AECs) to be tolerized has yet to be examined. We hypothesize that type II AECs will develop a tolerance phenotype upon repeated TLR agonist exposure. To test this hypothesis, primary AECs isolated from the lungs of mice and a murine AEC cell l...
Source: American Journal of Respiratory Cell and Molecular Biology - May 12, 2015 Category: Molecular Biology Authors: Neagos J, Standiford TJ, Newstead MW, Zeng X, Huang SK, Ballinger MN Tags: Am J Respir Cell Mol Biol Source Type: research

Devices for Dry Powder Drug Delivery to the Lung.
Abstract Dry powder inhalers (DPIs) are an important and increasingly investigated method of modern therapy for a growing number of respiratory diseases. DPIs are a promising option for certain patient populations, and may help to overcome several limitations that are associated with other types of inhalation delivery systems (e.g., accuracy and reproducibility of the dose delivered, compliance and adherence issues, or environmental aspects). Today, more than 20 different dry powder inhalers are on the market to deliver active pharmaceutical ingredients (APIs) for local and/or systemic therapy. Depending on the mec...
Source: AAPS PharmSciTech - May 12, 2015 Category: Drugs & Pharmacology Authors: Berkenfeld K, Lamprecht A, McConville JT Tags: AAPS PharmSciTech Source Type: research

Transfusion of fresher versus older red blood cells for all conditions.
CONCLUSIONS: Several factors precluded firm conclusions about the clinical outcomes of transfusing red blood cell units that have been stored for different periods of time before transfusion, including differences in clinical population and setting, diversity in the interventions used, methodological limitations and differences in how outcomes were measured and reported.No clear differences in the primary outcome - death - were noted between 'fresher' and 'older' or 'standard practice' red blood cells in trials that reported this outcome. Findings of a large number of ongoing trials will be incorporated into this review wh...
Source: Cochrane Database of Systematic Reviews - May 12, 2015 Category: Journals (General) Authors: Brunskill SJ, Wilkinson KL, Doree C, Trivella M, Stanworth S Tags: Cochrane Database Syst Rev Source Type: research

Foreign Body Inhalation in the Adult Population: Experience of 25,998 Bronchoscopies and Systematic Review of the Literature.
CONCLUSIONS: Foreign body aspiration is a rare indication for flexible bronchoscopy in adults. Flexible bronchoscopy has a high success rate in removal of inhaled foreign body and can be considered the preferred initial procedure for management of airway foreign bodies in adults. PMID: 25969517 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2015 Category: Respiratory Medicine Authors: Sehgal IS, Dhooria S, Ram B, Singh N, Aggarwal AN, Gupta D, Behera D, Agarwal R Tags: Respir Care Source Type: research

Relationship Between Clinical Variables and Health-Related Quality of Life in Young Adult Subjects With Cystic Fibrosis.
CONCLUSIONS: The sleep quality index score, 6MWD, sleepiness scale score, and FEV1 were predictors of WHOQOL-BREF scores. Age at diagnosis, clinical score, sleep quality score, 6MWD, sex, apnea-hypopnea index, BMI, current age, arousal index, FEV1, and pulmonary arterial systolic pressure were predictors of CFQOL scores. PMID: 25969516 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2015 Category: Respiratory Medicine Authors: Forte GC, Barni GC, Perin C, Casarotto FC, Fagondes SC, Dalcin PT Tags: Respir Care Source Type: research

Cognitive Behavioral Therapy for Management of Dyspnea: A Pilot Study.
CONCLUSION: The CBT program for the perceptual experience of breathlessness was feasible and well accepted by subjects, although the protocol raised a number of methodological limitations warranting modification. A larger randomized controlled trial is needed to determine the effectiveness and longer-term outcomes. PMID: 25969515 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2015 Category: Respiratory Medicine Authors: Williams MT, Cafarella P, Paquet C, Frith P Tags: Respir Care Source Type: research

Computerized Respiratory Sounds Are a Reliable Marker in Subjects With COPD.
CONCLUSIONS: Respiratory sound parameters are more reliable at an air flow of 0.4-0.6 L/s and are reliable overall at all anatomic locations. This should be considered in future studies using computerized auscultation. PMID: 25969514 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2015 Category: Respiratory Medicine Authors: Jácome C, Marques A Tags: Respir Care Source Type: research

Effect of Tidal Volume and Nebulizer Type and Position on Albuterol Delivery in a Pediatric Model of Mechanical Ventilation.
CONCLUSIONS: Optimization of inhaled drug delivery during pediatric mechanical ventilation should include careful selection of the type of delivery device and its placement in the ventilator circuit. Increasing VT during nebulization did not increase lung dose/delivery efficiency. PMID: 25969513 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 12, 2015 Category: Respiratory Medicine Authors: Berlinski A, Willis JR Tags: Respir Care Source Type: research

Flavobacterium procerum sp. nov., isolated from freshwater.
Abstract A Gram-reaction-negative, strictly aerobic, yellow-pigmented, rod-shaped bacterium, designated strain T3T, was isolated from freshwater of Chishui River flowing through Maotai town, Guizhou, southwest of China. The 16S rRNA gene sequence analysis indicated that strain T3T was a member of the genus Flavobacterium and closely related to Flavobacterium resistens DSM19382T (96.8%). The novel strain was able to grow at 10-34 °C (optimum 28 °C), pH 6.0-11.0 (optimum pH 8.0-9.0) and with 0-2.0% (w/v) NaCl (optimum 0 %). The major polar lipids were phosphatidylethanolamine (PE), two unknown glycolipid, five unkn...
Source: International Journal of Systematic and Evolutionary Microbiology - May 12, 2015 Category: Microbiology Authors: Feng Q, Han L, Yuan X, Tan X, Gao Y, Lv J Tags: Int J Syst Evol Microbiol Source Type: research

Coronavirus Infections in Pediatric Outpatients with Febrile Respiratory Tract Infections in Hiroshima, Japan, over a 3-Year Period.
In conclusion, the burden of human coronaviruses was relatively light among this cohort of 495 pediatric outpatients, and the incidence of these infections was low. PMID: 25971327 [PubMed - as supplied by publisher] (Source: Japanese Journal of Infectious Diseases)
Source: Japanese Journal of Infectious Diseases - May 12, 2015 Category: Infectious Diseases Authors: Hara M, Takao S Tags: Jpn J Infect Dis Source Type: research

What We Have Learned of the Influenza A pH1N1 2009/10 pandemic: High Clinical Impact of Human Metapneumovirus and Respiratory Syncytial Virus in Hospitalized Pediatric Patients.
Abstract The influenza pandemic in 2009/2010 shifted the public awareness to respiratory tract infections caused by influenza virus. A prospective study was conducted from November 2009 through April 2010 to determine the causing pathogens and clinical symptoms of all children and adolescents admitted for signs and symptoms of respiratory tract infections to the University Children's Hospital Duesseldorf, Germany during the influenza pandemic. A total number of 272 children and adolescents were admitted for acute respiratory tract infection (ARI) or influenza like illness symptoms (ILI). Viral pathogens were detect...
Source: Japanese Journal of Infectious Diseases - May 12, 2015 Category: Infectious Diseases Authors: Vogel M, Grund S, Pandey S, Mayatepek E, Schroten H, Tenenbaum T, Adams O Tags: Jpn J Infect Dis Source Type: research

Phytochemical distinction between Pelargonium sidoides (“Umckaloabo”) and P.   reniforme through 1 H-NMR and UHPLC–MS metabolomic profiling
Abstract Two Pelargonium species which are indigenous to South Africa; P. sidoides DC and P. reniforme Curt., are highly valued traditional remedies used primarily for the treatment of upper respiratory tract infections. The ethnobotanical value of P. sidoides has led to the commercialisation of herbal medicinal products such as Umckaloabo® that are marketed internationally. Although the two species can be distinguished by leaf shape and flower colour, the rhizomes which are used for preparation of the commercial extracts are morphologically similar. Non-targeted 1H-NMR and UHPLC–MS metabolomic approaches w...
Source: Metabolomics - May 11, 2015 Category: Biology Source Type: research

Morphological impact of zinc oxide particles on the antibacterial activity and human epithelia toxicity.
Abstract ZnO nanoparticles are utilized in an ever growing number of products and can, therefore, be readily encountered in our everyday life. Human beings' outermost tissues consist of different epithelia and are, therefore, the most exposed to materials from the environment. In this paper, Caco-2 and Calu-3 cell lines were used, having been previously broadly applied for in vitro modelling of intestinal and respiratory epithelia, respectively. The toxicity of synthesized micro-, submicro- and nanoparticulate ZnO on these epithelia was measured and compared to the efficacy of the same ZnO particles as antibacteria...
Source: Appl Human Sci - May 11, 2015 Category: Physiology Authors: Čepin M, Hribar G, Caserman S, Orel ZC Tags: Mater Sci Eng C Mater Biol Appl Source Type: research

PPAR‐α agonist elicits metabolically active brown adipocytes and weight loss in diet‐induced obese mice
This study aimed to examine the effects of fenofibrate on energy expenditure, body mass (BM) and gene expression of thermogenic factors in brown adipose tissue of diet‐induced obese mice. Male C57BL/6 mice were fed a standard chow (SC; 10% lipids) diet or a high‐fat (HF; 50% lipids) diet for 10 weeks. Afterwards, groups were subdivided as SC, SC‐F, HF and HF‐F (n = 10, each). Treatment with fenofibrate (100 mg kg−1 BM mixed into the diet) lasted 5 weeks. Treated groups had reduced final BM compared with their counterparts (p < 0·05), explained by the increase in energy expenditure, CO2 product...
Source: Cell Biochemistry and Function - May 11, 2015 Category: Biochemistry Authors: Tamiris Lima Rachid, Aline Penna‐de‐Carvalho, Isabele Bringhenti, Marcia Barbosa Aguila, Carlos Alberto Mandarim‐de‐Lacerda, Vanessa Souza‐Mello Tags: Research Article Source Type: research

Carbapenemase-producing Enterobacteriaceae in Sweden 2007-2013: experiences from seven years of systematic surveillance and mandatory reporting
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing worldwide, and are a major threat to healthcare systems. Recent European data support that many countries have interregional spread of CPE or an endemic situation. In Sweden mandatory laboratory reporting of CPE of both colonisation and infection has been practiced since 2007 and since 2012 also by treating physicians. Between 2007 and 2013, 94 cases of CPE were detected in Sweden, out of which 24 were considered to cause clinical infections (bloodstream infection (n=4), urinary tract infection (n=12), wound infection (n= 4), respiratory tract infection (n=2) ...
Source: Drug Resistance Updates - May 11, 2015 Category: Drugs & Pharmacology Authors: Sonja Löfmark, Karin Sjöström, Barbro Mäkitalo, Petra Edquist, Karin Tegmark-Wisell, Christian G. Giske Source Type: research

On Chlorofluorocarbon Bans and Inhaled Albuterol Prices
The competing concerns and interests of both individuals and society must be considered when establishing regulatory policy. In 2008, the US Food and Drug Administration (FDA) banned albuterol inhalers containing chlorofluorocarbons. This decision was questioned at the time because the chlorofluorocarbons emitted from inhalers have an insignificant effect on ozone and because of the anticipated costs of transitioning to hydrofluoroalkane inhalers for patients with respiratory disease. With the ban, generically manufactured chlorofluorocarbon inhalers were discontinued, leaving only branded hydrofluoroalkane inhalers availa...
Source: JAMA Internal Medicine - May 11, 2015 Category: Internal Medicine Source Type: research

Symptoms as the main problem in primary care: A cross-sectional study of frequency and characteristics.
CONCLUSION: Interpretation and management of symptoms is a key task in primary care. As symptoms are highly frequent in general practice, symptoms without a specific diagnosis constitute a challenge to GPs. Nevertheless, symptoms have been given little priority in research. More attention should be directed to evidence-based management of symptoms as a generic phenomenon to ensure improved outcomes in the future. PMID: 25961812 [PubMed - as supplied by publisher] (Source: Primary Care)
Source: Primary Care - May 11, 2015 Category: Primary Care Authors: Rosendal M, Carlsen AH, Rask MT, Moth G Tags: Scand J Prim Health Care Source Type: research

Airway Remodeling in Preschool Children with Severe Recurrent Wheeze.
CONCLUSIONS: In preschoolers with severe recurrent wheeze, markers of remodeling and inflammation are unrelated, and atopy is associated with ASM. In the absence of controls, we cannot determine whether differences observed in RBM thickness and vascularity result from disease or normal age-related development. PMID: 25961111 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 11, 2015 Category: Respiratory Medicine Authors: Lezmi G, Gosset P, Deschildre A, Abou-Taam R, Mahut B, Beydon N, de Blic J Tags: Am J Respir Crit Care Med Source Type: research

Development of influenza A(H7N9) candidate vaccine viruses with improved hemagglutinin antigen yield in eggs
ConclusionsIf influenza A(H7N9) viruses were to acquire sustained human to human transmissibility, the improved HA yield of the egg‐passaged CVVs generated in this study could expedite vaccine manufacturing for pandemic mitigation.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - May 11, 2015 Category: Virology Authors: Callie Ridenour, Adam Johnson, Emily Winne, Jaber Hossain, Guaniri Mateu‐Petit, Amanda Balish, Wanda Santana, Taejoong Kim, Charles Davis, Nancy J. Cox, John R. Barr, Ruben O. Donis, Julie Villanueva, Tracie L. Williams, Li‐Mei Chen Tags: Original Article Source Type: research

Admission neurophysiological abnormalities in Guillain-Barré syndrome: a single-center experience
Guillain-Barré syndrome (GBS) is a post-infectious disorder that usually occurs in otherwise healthy people. The main features of GBS are rapidly progressive bilateral and relatively symmetric weakness of the limbs. This may include the involvement of respiratory muscles or cranial nerve-innervated muscles ([1,2]; [3]; [4]). (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 11, 2015 Category: Neurosurgery Authors: Marco Luigetti, Serenella Servidei, Anna Modoni, Paolo Maria Rossini, Mario Sabatelli, Mauro Lo Monaco Source Type: research

Pneumonia and Inflammatory Arthritis Caused by Unusual Occupational Exposure or a Life-Threatening Infection Resulting From a More Commonly Encountered Mechanism?
A 44-YEAR-OLD RENOVATION CONTRACTOR with a history of chronic low back pain developed symptoms consistent with an upper respiratory infection approximately 3 days after removing carpeting on which a decomposing human body recently had been discovered. The contractor was not wearing a respirator when he performed the work. He initially ignored his symptoms, but he eventually sought medical attention at a local community hospital complaining of a persistent fever, chills, night sweats, weight loss, a productive cough, dyspnea, orthopnea, and chest “heaviness” that was exacerbated with activity and partially relieved with...
Source: Journal of Cardiothoracic and Vascular Anesthesia - May 11, 2015 Category: Anesthesiology Authors: Derek J. De Vry, Paul H. Barker, Marina Vardanyan, Staci L. Milosavljevic, Timo N. Dygert, Jason W. Jurva, Moritz C. Wyler Van Ballmoos, Sweeta D. Gandhi, G. Hossein Almassi, Paul S. Pagel Tags: Diagnostic Dilemma Source Type: research

Quantitative systematic review of the associations between short-term exposure to nitrogen dioxide and mortality and hospital admissions
Conclusions Our review provides clear evidence of health effects associated with short-term exposure to NO2 although further work is required to understand reasons for the regional heterogeneity observed. The growing literature, incorporating large multicentre studies and new evidence from less well-studied regions of the world, supports further quantitative review to assess the independence of NO2 health effects from other air pollutants. (Source: BMJ Open)
Source: BMJ Open - May 11, 2015 Category: Journals (General) Authors: Mills, I. C., Atkinson, R. W., Kang, S., Walton, H., Anderson, H. R. Tags: Open access, Epidemiology Research Source Type: research

Association of child health and household amenities in high focus states in India: a district-level analysis
Conclusions Although child healthcare services are important in addressing child health issues, they barely touch on the root of the problem. Building toilets and providing safe drinking water, clean cooking fuel and drainage facilities at the household level, may prevent a number of adverse child health issues and may reduce the burden on the healthcare system in India. (Source: BMJ Open)
Source: BMJ Open - May 11, 2015 Category: Journals (General) Authors: Gouda, J., Gupta, A. K., Yadav, A. K. Tags: Open access, Global health, Paediatrics, Public health, Research methods Source Type: research

Phaeodactylibacter luteus sp. nov., isolated from the oleaginous microalga Picochlorum sp.
Abstract A Gram-staining-negative, orange-pigmented, non-motile, aerobic bacterial strain, designated GYP20T, was isolated from a culture of the alga Picochlorum sp., a promising feedstock for biodiesel production, which was isolated from the India Ocean. Growth was observed at temperatures from 20 to 37 °C, at salinities from 0 to 3% and at pH from 5 to 9. Mg2+ and Ca2+ ions are required for growth. Phylogenetic analysis based on 16S rRNA gene sequencing revealed that the strain was a member of the genus Phaeodactylibacter, which belongs to the family Saprospiraceae. Strain GYP20T was most closely related to Phae...
Source: International Journal of Systematic and Evolutionary Microbiology - May 11, 2015 Category: Microbiology Authors: Lei X, Li Y, Wang G, Chen Y, Lai Q, Chen Z, Zhang J, Liao P, Zhu H, Zheng W, Zheng T Tags: Int J Syst Evol Microbiol Source Type: research

Pitfalls in flow cytometric analyses of surfactant-exposed human leukocytes.
CONCLUSION: Reliable detection of intracellular cytokines by flow cytometry may be challenging in surfactant-exposed cell samples due to significant autofluorescence of aggregated phospholipid particles. This issue has been addressed for the first time and may be of high relevance for all types of surfactant research. We demonstrate that a methanol-based permeabilization approach completely removes interfering fluorescent surfactant micelles and allowes for correct evaluation of data. The successful removal of confounding surfactant phospholipids opens up a wide variety of multiparameter flow cytometry; a method that has n...
Source: Immunology Letters - May 11, 2015 Category: Allergy & Immunology Authors: Glaser K, Fehrholz M, Seidenspinner S, Ottensmeier B, Wollny B, Kunzmann S Tags: Immunol Lett Source Type: research

The emerging role of Nrf2 in mitochondrial function.
Abstract The transcription factor NF-E2 p45-related factor 2 (Nrf2, gene name NFE2L2) allows adaptation and survival under conditions of stress by regulating the gene expression of diverse networks of cytoprotective proteins, including antioxidant, anti-inflammatory, detoxification enzymes as well as proteins which assist in repair or removal of damaged macromolecules. Nrf2 has a crucial role in the maintenance of the cellular redox homeostasis by regulating the biosynthesis, utilization and regeneration of glutathione, thioredoxin and NADPH, and by controlling production of reactive oxygen species by mitochondria ...
Source: Free Radical Biology and Medicine - May 11, 2015 Category: Biology Authors: Dinkova-Kostova AT, Abramov AY Tags: Free Radic Biol Med Source Type: research

Malignant mesothelioma as an oxidative stress-induced cancer: An update.
Abstract Malignant mesothelioma (MM) is a relatively rare cancer that occurs almost exclusively following respiratory exposure to asbestos in humans. Its pathogenesis is closely associated with iron overload and oxidative stress in mesothelial cells. Upon fiber exposure, mesothelial cells accumulate fibers simultaneously with iron, which either performs physical scissor function or catalyzes free radical generation, leading to oxidative DNA damage such as strand breaks and base modifications, followed by activation of intracellular signaling pathways. Chrysotile, per se without iron, causes massive hemolysis and fu...
Source: Free Radical Biology and Medicine - May 11, 2015 Category: Biology Authors: Chew SH, Toyokuni S Tags: Free Radic Biol Med Source Type: research

Admission neurophysiological abnormalities in Guillain–Barré syndrome: A single-center experience
Guillain–Barré syndrome (GBS) is a post-infectious disorder that usually occurs in otherwise healthy people. The main features of GBS are rapidly progressive bilateral and relatively symmetric weakness of the limbs. This may include the involvement of respiratory muscles or cranial nerve-innervated muscles [1–4]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - May 11, 2015 Category: Neurosurgery Authors: Marco Luigetti, Serenella Servidei, Anna Modoni, Paolo Maria Rossini, Mario Sabatelli, Mauro Lo Monaco Source Type: research

Carbapenemase-producing Enterobacteriaceae in Sweden 2007–2013: Experiences from seven years of systematic surveillance and mandatory reporting
Carbapenemase-producing Enterobacteriaceae (CPE) are increasing worldwide, and are a major threat to healthcare systems. Recent European data support that many countries have interregional spread of CPE or an endemic situation. In Sweden mandatory laboratory reporting of CPE of both colonisation and infection has been practiced since 2007 and since 2012 also by treating physicians. Between 2007 and 2013, 94 cases of CPE were detected in Sweden, out of which 24 were considered to cause clinical infections (bloodstream infection (n=4), urinary tract infection (n=12), wound infection (n=4), respiratory tract infection (n=2) a...
Source: Drug Resistance Updates - May 11, 2015 Category: Drugs & Pharmacology Authors: Sonja Löfmark, Karin Sjöström, Barbro Mäkitalo, Petra Edquist, Karin Tegmark Wisell, Christian G. Giske Source Type: research

Pharmacodynamics and Pharmacokinetics
Persson PB (Source: International Journal of COPD)
Source: International Journal of COPD - May 10, 2015 Category: Respiratory Medicine Source Type: research

An algorithm to diagnose influenza infection: evaluating the clinical importance and impact on hospital costs of screening with rapid antigen detection tests
Abstract Rapid antigen detection tests (RADTs) are immunoassays that produce results in 15 min or less, have low sensitivity (50 %), but high specificity (95 %). We studied the clinical impact and laboratory savings of a diagnostic algorithm for influenza infection using RADTs as a first-step technique during the influenza season. From January 15th to March 31st 2014, we performed a diagnostic algorithm for influenza infection consisting of an RADT for all respiratory samples received in the laboratory. We studied all the patients with positive results for influenza infection, dividing them into two groups: Gr...
Source: European Journal of Clinical Microbiology and Infectious Diseases - May 10, 2015 Category: Microbiology Source Type: research

Solid Fuel in Kitchen and Acute Respiratory Tract Infection Among Under Five Children: Evidence from Nepal Demographic and Health Survey 2011
This study assessed the association between use of solid fuel in kitchen and ARI among under five children in Nepal. The latest data from the Nepal Demographic and Health Survey 2011 were used. A total of 4,802 under 5 de-jure children were included in this analysis. Cough accompanied by short/rapid breath and chest problem within 2 weeks before survey was considered as the symptoms of ARI. Logistic regression analysis was performed to calculate the odds of being suffered from ARI among the children from households using solid fuel in comparison to the children from households using cleaner fuel. About 84.6 % of the fami...
Source: Journal of Community Health - May 10, 2015 Category: Global & Universal Source Type: research

Influence of a montmorency cherry juice blend on indices of exercise-induced stress and upper respiratory tract symptoms following marathon running—a pilot investigation
Background: Prolonged exercise, such as marathon running, has been associated with an increase in respiratory mucosal inflammation. The aim of this pilot study was to examine the effects of Montmorency cherry juice on markers of stress, immunity and inflammation following a Marathon. Methods: Twenty recreational Marathon runners consumed either cherry juice (CJ) or placebo (PL) before and after a Marathon race. Markers of mucosal immunity secretory immunoglobulin A (sIgA), immunoglobulin G (IgG), salivary cortisol, inflammation (CRP) and self-reported incidence and severity of upper respiratory tract symptoms (URTS) were m...
Source: BioMed Central - May 10, 2015 Category: Journals (General) Authors: Lygeri DimitiouJessica A HillAhmed JehnaliJoe DunbarJames BrounerMalachy McHughGlyn Howatson Source Type: research

Expression of VEGF in neonatal urinary obstruction: does expression of VEGF predict hydronephrosis?
CONCLUSIONS The pressure due to congenital urogenital obstruction resulting in mechanical stress in cells did not increase the expression of VEGF in young children in our study. To find a correlation between urogenital tract obstruction and increased expression of VEGF, we need to perform more examinations because the connection may be of therapeutic significance. PMID: 25951999 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 10, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Analgesia and Respiratory Function after Laparoscopic Cholecystectomy in Patients receiving Ultrasound-Guided Bilateral Oblique Subcostal Transversus Abdominis Plane Block: A Randomized Double-Blind Study.
CONCLUSIONS After laparoscopic cholecystectomy, OSTAP block can provide significant improvement in respiratory function and better pain relief with lower opioid requirement. PMID: 25948166 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - May 10, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Vitamin D supplementation: a comprehensive review on supplementation for tuberculosis prophylaxis
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - May 10, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma
Background: In airways, a proliferative effect is played directly by cholinergic agonists through nicotinic and muscarinic receptors activation. How tumors respond to aberrantly activated cholinergic signalling is a key question in smoking-related cancer. This research was addressed to explore a possible link of cholinergic signalling changes with cancer biology. Methods: fifty-seven paired pieces of head and neck squamous cell carcinoma (HNSCC) and adjacent non-cancerous tissue (ANCT) were compared for their mRNA levels for ACh-related proteins and ACh-hydrolyzing activity. Results: The measurement in ANCT of acetylcholin...
Source: BMC Cancer - May 10, 2015 Category: Cancer & Oncology Authors: Ana Castillo-GonzálezSusana Nieto-CerónJuan Pelegrín-HernándezMaría MontenegroJosé NogueraMaría López-MorenoJosé Rodríguez-LópezCecilio VidalDiego Hellín-MeseguerJuan Cabezas-Herrera Source Type: research

New insights on the role of the insular cortex and habenula in OSA
Conclusions The Ic may be an important region in the development of OSA. Altered activity in the limbic system and its related structures could also be associated with OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - May 10, 2015 Category: Respiratory Medicine Source Type: research