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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

An Official American Thoracic Society Research Statement: A Research Framework for Pulmonary Nodule Evaluation and Management.
CONCLUSIONS: This statement may help researchers to develop impactful and innovative research projects and enable funders to better judge research proposals. We hope that it will accelerate the pace and increase the efficiency of discovery to improve the quality of care for patients with pulmonary nodules. PMID: 26278796 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Slatore CG, Horeweg N, Jett JR, Midthun DE, Powell CA, Wiener RS, Wisnivesky JP, Gould MK, ATS Ad Hoc Committee on Setting a Research Framework for Pulmonary Nodule Evaluation Tags: Am J Respir Crit Care Med Source Type: research

Update in Sleep Medicine 2014.
PMID: 26278795 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Ayas NT, Owens RL, Kheirandish-Gozal L Tags: Am J Respir Crit Care Med Source Type: research

Tuberculosis and World War I.
PMID: 26278794 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Murray JF Tags: Am J Respir Crit Care Med Source Type: research

Diagnosis of Tuberculosis in Children Using Mycobacteria-Specific Cytokine Responses. Are There Reasons for Hope?
PMID: 26278793 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Gomez-Pastrana D, Domínguez J Tags: Am J Respir Crit Care Med Source Type: research

Upper Room Germicidal Ultraviolet Systems for Air Disinfection Are Ready for Wide Implementation.
PMID: 26278792 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Miller SL Tags: Am J Respir Crit Care Med Source Type: research

Ultrathin Is In: A New Option for Peripheral Pulmonary Nodules.
PMID: 26278791 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Michaud G, Sterman DH Tags: Am J Respir Crit Care Med Source Type: research

The Implications of a Tracheostomy for Discharge Destination.
PMID: 26278790 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Scales DC Tags: Am J Respir Crit Care Med Source Type: research

Outside In: Sequencing the Lung Microbiome.
PMID: 26278789 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2015 Category: Respiratory Medicine Authors: Cox MJ, Moffatt MF, Cookson WO Tags: Am J Respir Crit Care Med Source Type: research

Multi-center evaluation of a user-friendly lateral flow assay to determine IP-10 and CCL4 levels in blood of TB and non-TB cases in Africa.
CONCLUSION: This African multi-center trial further demonstrated the applicability of the low-tech and robust UCP-LF platform as a convenient quantitative assay for chemokine detection in whole blood. Ambient shipping and storage of all assay reagents and the availability of lightweight standalone readers were acknowledged as essential requirement for test implementation in particular in remote and resource-limited settings. PMID: 26285074 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - August 15, 2015 Category: Biochemistry Authors: Corstjens PL, Tjon Kon Fat EM, de Dood CJ, van der Ploeg-van Schip JJ, Franken KL, Chegou NN, Sutherland JS, Howe R, Mihret A, Kassa D, van der Vyver M, Sheehama J, Simukonda F, Mayanja-Kizza H, Ottenhoff TH, Walzl G, Geluk A, AE-TBC consortium Tags: Clin Biochem Source Type: research

Osteosclerotic metaphyseal dysplasia with extensive interstitial pulmonary lesions: a case report and literature review
Abstract Osteosclerotic metaphyseal dysplasia (OMD) is a very rare sclerosing bone disorder. To date, four cases have been documented in three reports. Here, we present the case of a 12-year-old girl with a history of recurrent respiratory infections, hypotonia, developmental delay, genu valgum, and hepatosplenomegaly. Radiographs revealed profound, ivory-white sclerosis of the metaphyses and epiphyses of the long bones in both the upper and lower extremities. Sclerosis also affected the ends or margins of the flat bones, including the mandible, clavicles, scapulae, ribs, iliac crests, ischia, pubic bones, talus,...
Source: Skeletal Radiology - August 14, 2015 Category: Radiology Source Type: research

Perioperative Major Non-neurological Complications in 105 Patients Undergoing Posterior Vertebral Column Resection Procedures for Severe Rigid Deformities
Conclusion. Patients who had undergone PVCR experienced expected higher rate of MNNCs, with an overall prevalence of 22.9%. When considering PVCR, it is important to recognize the significantly higher inherent risks and provide appropriate preoperative counseling on the risks and benefits of surgery. Level of Evidence: 3 (Source: Spine)
Source: Spine - August 14, 2015 Category: Orthopaedics Tags: Deformity Source Type: research

Contributions of Comorbid Diabetes to Sleep Characteristics, Daytime Symptoms, and Physical Function Among Patients With Stable Heart Failure
Conclusions: Comorbid DM contributes independent and additive effects on sleep disturbances and poor physical functioning in patients with stable HF. (Source: Journal of Cardiovascular Nursing)
Source: Journal of Cardiovascular Nursing - August 14, 2015 Category: Nursing Tags: Articles Source Type: research

[Correspondence] Parenteral antibiotics are not enough to prevent pneumonia in stroke – Authors' reply
The susceptibility of patients with stroke to pneumonia has been well recognised,1 and its cause is multifactorial.2 Luciano Silvestri and colleagues rightly point out pathophysiological differences between early pneumonia after stroke, defined as within the first week after stroke onset, and late pneumonia, defined as after the first week. The Pneumonia In Stroke ConsEnsuS (PISCES) group has recently recommended reserving the term stroke-associated pneumonia for the spectrum of lower respiratory tract infections within the first 7 days after stroke onset. (Source: LANCET)
Source: LANCET - August 14, 2015 Category: Journals (General) Authors: Diederik van de Beek, Matthijs Brouwer, Paul Nederkoorn Tags: Correspondence Source Type: research

Species C is Predominant in Chinese Children with Acute Respiratory Adenovirus Infection
No abstract available (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: Letters to the Editor Source Type: research

Clinical Predictors of Culture-confirmed Pulmonary Tuberculosis in Children in a High Tuberculosis and HIV Prevalence Area
Conclusions: Prolonged fever, CXR suggestive of TB or a positive TST were predictive of definite TB and should be considered in composite scoring systems for TB diagnosis in high HIV prevalence settings. Other commonly associated symptoms were not associated with definite TB. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: HIV Reports Source Type: research

Eighteen Years of Respiratory Syncytial Virus Surveillance: Changes in Seasonality and Hospitalization Rates in Southwestern Alaska Native Children
Conclusions: Although the RSV hospitalization rate decreased 3-fold, YKD infants still experience a hospitalization rate 3-fold higher than the general US infant population. Overcrowding and lack of plumbed water were associated with RSV hospitalization. Dramatic changes occurred in RSV seasonality, not explained by changes in climate. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

The Gene Polymorphism of IL-17 G-152A is Associated with Increased Colonization of Streptococcus pneumoniae in Young Finnish Children
Conclusions: Our results indicate that IL-17 G-152A is associated with increased colonization rate of S. pneumoniae in young children, suggesting that IL-17A plays an important role in protection against pneumococcal colonization. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 14, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

Absence of Typical Symptoms and Comorbidities in Patients with Central Sleep Apnea.
This article examines retrospectively the possible association of central sleep apnea with special sleep-related symptoms and various co-morbidities. Data of all patients with different types of central sleep apnea were collected from our hospital charts within the Department of Pneumology, HELIOS Clinic, University of Witten/Herdecke, Wuppertal, Germany, within the study period of January 1, 2011 to September 19, 2014. After clinical examination, all patients underwent polysomnography in our sleep laboratory. We identified a total of 60 (3.5 %) patients with central sleep apnea from 1722 patients with assumed sleep disor...
Source: Advances in Experimental Medicine and Biology - August 14, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Assessment of the Mechanistic Role of Cinnarizine in Modulating Experimentally-Induced Bronchial Asthma in Rats
Conclusion: Cinnarizine may protect against experimental bronchial asthma. Suppressant effect of cinnarizine on pro-inflammatory cytokines release, IgE antibody production, eosinophil infiltration as well as oxidative and nitrosative stress may explain its anti-asthmatic potential.Pharmacology 2015;96:167-174 (Source: Pharmacology)
Source: Pharmacology - August 14, 2015 Category: Drugs & Pharmacology Source Type: research

Emerging Oral Immunomodulators for the Treatment of Psoriasis: A Review of Phase III Clinical Trials for Apremilast and Tofacitinib.
CONCLUSION: Both new oral medications, apremilast and tofacitinib, appear to be effective in treating psoriasis.<br /><br /> <em>J Drugs Dermatol.</em> 2015;14(8):786-792. PMID: 26267722 [PubMed - in process] (Source: Journal of Drugs in Dermatology)
Source: Journal of Drugs in Dermatology - August 14, 2015 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Pulmonary hypertension trials: how can we do better?
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - August 14, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Nijmegen Breakage Syndrome: Clinical and Immunological Features, Long-Term Outcome and Treatment Options – a Retrospective Analysis
Conclusions The extremely high incidence of malignancies, mostly non-Hodgkin’s lymphomas, was the main risk factor affecting survival probability in NBS patients. Because treatment of NBS is very difficult and frequently unsuccessful, the search for an alternative medical intervention such as hematopoietic stem cell transplantation is of great clinical importance. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - August 14, 2015 Category: Allergy & Immunology Source Type: research

Leucomycin-induced acute generalized exanthematous pustulosis complicated with pitting edema of the legs
Publication date: September 2015 Source:Dermatologica Sinica, Volume 33, Issue 3 Author(s): Chu-Ju Hung, Jen-Jung Cheng, Po-Ju Lai, Wea-Lung Lin, Yu-Ping Hsiao Acute generalized exanthematous pustulosis (AGEP) is characterized by fever, sterile nonfollicular pustules, and neutrophilia. More than 90% of cases of AGEP are induced by antibiotics such as aminopenicillins and macrolides. However, little is known about the side effects associated with leucomycin. To the best of our knowledge, the following case is the first one reporting leucomycin-induced AGEP. The case presented here is of a 43-year-old man who suffered...
Source: Dermatologica Sinica - August 14, 2015 Category: Dermatology Source Type: research

Effect of Inhaled Corticosteroids on Salival Composition: A Cross-Sectional Study in Patients with Bronchial Asthma
Conclusion In patients with asthma, treatment with high-doses of ICs is associated with reduced levels of salivary MUC5B. This effect can explain some of the effects of ICs on oral health. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - August 14, 2015 Category: Drugs & Pharmacology Source Type: research

Changes in microbiota during experimental human Rhinovirus infection
Conclusions: HRV16 infection is associated with the increase of three genera known to be associated with secondary infections following HRV infections. The observed changes of upper respiratory tract microbiota could help explain why HRV infection predisposes to bacterial otitis media, sinusitis and pneumonia. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - August 14, 2015 Category: Infectious Diseases Authors: J. HofstraS. MatamorosM. van de PolB. de WeverM. TanckH. Wendt-KnolM. DeijsL. van der HoekK. WolthersR. MolenkampC. VisserP. SterkR. LutterM. de Jong Source Type: research

Antibiotic susceptibility of Neochlamydia hartmanellae and Parachlamydia acanthamoebae in amoebae
In this study, we defined the antibiotic susceptibility of Neochlamydia hartmanellae, two strains of Parachlamydia acanthamoebae and two yet unclassified Parachlamydiaceae strains using a quantitative approach. We confirmed the results obtained earlier for P. acanthamoebae strain Bn9 in an observational study. Macrolides (MICs &lt; 0.06 - 0.5 μg/ml), rifampicin (MICs 0.25-0.5, 1-2 μg/ml) and doxycycline were active against P. acanthamoebae strains and Neochlamydia. All strains were resistant to amoxicillin, ceftriaxone and imipenem (MIC &gt;32 μg/ml). Similarly to other Chlamydia-related bacteria, all investigat...
Source: Microbes and Infection - August 14, 2015 Category: Infectious Diseases Source Type: research

Can an antimicrobial stewardship program reduce length of stay of immune-competent adult patients admitted to hospital with diagnosis of community-acquired pneumonia? Study protocol for pragmatic controlled non-randomized clinical study
DiscussionBy designing a pragmatic clinical trial with unique design and analytic features, we not only expect to demonstrate the effectiveness of a real-world ASP, but also provide a model for program evaluation that can be used more broadly to improve patient safety and quality of care.Trial registrationClinicalTrials.gov NCT02264756. (Source: Trials)
Source: Trials - August 14, 2015 Category: Journals (General) Authors: Giulio DiDiodatoLeslie McArthurJoseph BeyeneMarek SmiejaLehana Thabane Source Type: research

Decadal transition of adult mortality pattern at Ballabgarh HDSS: evidence from verbal autopsy data
Conclusion: Mortality surveillance using verbal autopsy tool revealed a transition in cause specific deaths from respiratory diseases to cardiovascular diseases over the decade. The apparent epidemiological transition in the community demands reorientation of healthcare priorities. (Source: BMC Public Health)
Source: BMC Public Health - August 14, 2015 Category: Consumer Health News Authors: Sanjay RaiArti GuptaRahul SrivastavaMohan BairwaPuneet MisraShashi KantChandrakant Pandav Source Type: research

EXPOsure: Milan, May 1st- October 31st 2015
The city of Milan is experiencing the great event of EXPO 2015 and heavy construction has been ongoing since 2012 over an area of more than 1 million meters squared in the north-west suburban area of the city. We compared the number of hospital admissions for upper and lower respiratory tract infections (URTI and LRTI) and acute asthma, in infants and children aged between 0 and 13 years from 2011 to 2014 in two Pediatric Departments, one near and one far from the EXPO construction area. Hospital admission frequencies resulted to be similar in the two Pediatric Departments. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - August 14, 2015 Category: Pediatrics Authors: Gian ZuccottiMarco MorelliMarco SalaGiorgio BedogniValentina Fabiano Source Type: research

EXPOsure: Milan, May 1st- October 31st 2015
Abstract The city of Milan is experiencing the great event of EXPO 2015 and heavy construction has been ongoing since 2012 over an area of more than 1 million meters squared in the north-west suburban area of the city. We compared the number of hospital admissions for upper and lower respiratory tract infections (URTI and LRTI) and acute asthma, in infants and children aged between 0 and 13 years from 2011 to 2014 in two Pediatric Departments, one near and one far from the EXPO construction area. Hospital admission frequencies resulted to be similar in the two Pediatric Departments. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - August 14, 2015 Category: Pediatrics Source Type: research

Hemodynamic monitoring using a single-use indwelling transesophageal echocardiography probe in an unstable patient after open-heart surgery
Conclusions: The novel hemodynamic monitoring device described here appears valuable to help identifying severe post-operative complications and guide acute care. (Source: BMC Medical Imaging)
Source: BMC Medical Imaging - August 14, 2015 Category: Radiology Authors: Emmanuelle BegotMarc ClavelAlessandro PiccardoRémi BellierBruno FrançoisNicolas PichonPhilippe Vignon Source Type: research

Analyses of melatonin, cytokines, and sleep in chronic renal failure
Conclusion These results suggest that the sleep disorders observed in the CRF group were probably related to the low production of melatonin observed in this population. The high level of TNF, as previously demonstrated in other pathologies, is probably involved in this blockage of melatonin production in CRF. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 14, 2015 Category: Respiratory Medicine Source Type: research

Oral health in patients treated by positive airway pressure for obstructive sleep apnea: a population-based case–control study
Conclusion Oral health of OSA patients treated by CPAP/BiPAP is comparable to that of matched controls in terms of amount of plaque, gingival inflammation, and masticatory function. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 14, 2015 Category: Respiratory Medicine Source Type: research

Might your respiratory patient have alpha-1 antitrypsin deficiency?
Publication date: Available online 8 August 2015 Source:Heart &amp; Lung: The Journal of Acute and Critical Care Author(s): Robert A. Sandhaus, Ann R. Knebel (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 14, 2015 Category: Respiratory Medicine Source Type: research

Roflumilast for asthma: Weighing the evidence
Publication date: Available online 13 August 2015 Source:Pulmonary Pharmacology &amp; Therapeutics Author(s): E.D. Bateman, P.M. O’Byrne, R. Buhl, K.F. Rabe (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - August 14, 2015 Category: Respiratory Medicine Source Type: research

A valid option for asthma control: clinical evidence on efficacy and safety of fluticasone propionate/formoterol combination in a single inhaler
Publication date: Available online 13 August 2015 Source:Pulmonary Pharmacology &amp; Therapeutics Author(s): M. Latorre, P. Paggiaro, W. Canonica, M.P. Foschino, A. Papi A good level of asthma control improves the quality of life of asthmatic patients and may prevent future risk in term of exacerbations and decline of pulmonary function. However, in a real-life setting, several factors contribute to generally low compliance to the treatment. A rapid-onset, long-lasting medication with few adverse effects may contribute to improve adherence to therapy, along with an effective patient education and a good physici...
Source: Pulmonary Pharmacology and Therapeutics - August 14, 2015 Category: Respiratory Medicine Source Type: research

Update on the combination effect of macrolide antibiotics in community-acquired pneumonia
Publication date: Available online 13 August 2015 Source:Respiratory Investigation Author(s): M. Emmet O’Brien, Marcos I. Restrepo, Ignacio Martin-Loeches Community-acquired pneumonia (CAP) is a leading cause of death from an infectious cause worldwide. Guideline-concordant antibiotic therapy initiated in a timely manner is associated with improved treatment responses and patient outcomes. In the post-antibiotic era, much of the morbidity and mortality of CAP is as a result of the interaction between bacterial virulence factors and host immune responses. In patients with severe CAP, or who are critically ill, there ...
Source: Respiratory Investigation - August 14, 2015 Category: Respiratory Medicine Source Type: research

Promising effect of chemotherapy with bevacizumab for patients with pulmonary pleomorphic carcinoma: Two case reports and a literature review
Publication date: Available online 12 August 2015 Source:Respiratory Investigation Author(s): Tsuneyuki Oda, Akimasa Sekine, Terufumi Kato, Tomohisa Baba, Koji Okudela, Takashi Ogura Pulmonary pleomorphic carcinoma (PPC) is a rare disease with a poor prognosis. Chemotherapy regimens used to date have not been effective against PPC; thus, a new treatment strategy is needed. Here, we report two patients with PPC who were effectively treated with a chemotherapy regimen including bevacizumab. Both patients received carboplatin/paclitaxel/bevacizumab and showed a partial response. As patients with PPC have been reported...
Source: Respiratory Investigation - August 14, 2015 Category: Respiratory Medicine Source Type: research