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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

Lumbo-sacral epidural anaesthesia as a complement to dissociative anaesthesia during scrotal herniorrhaphy of livestock pigs in the field
Background: In Sweden, scrotal or inguinal herniorrhaphy of livestock pigs in the field has traditionally been an important part of the surgical skills training of veterinary students. Few substances meet the legal requirements for field anaesthesia of production animals in the European Union but a protocol based on azaperone-detomidine-butorphanol-ketamine does. Unfortunately the anaesthesia is characterised by unpredictable duration and depth and of abrupt awakenings which is not acceptable from an animal welfare perspective and impedes surgical training. Lumbo-sacral epidural analgesia is proven to provide sufficient an...
Source: Acta Veterinaria Scandinavica - June 24, 2015 Category: Veterinary Research Authors: Carl EkstrandMarie SterningLove BohmanAnna Edner Source Type: research

Regulation of chicken immunity-related genes and host response profiles against Avibacterium paragallinarum pathogen challenge
Publication date: Available online 14 June 2015 Source:Veterinary Immunology and Immunopathology Author(s): Charlotte E. Boucher , Chrispian W. Theron , Arina C. Hitzeroth , Robert R. Bragg Infectious coryza (IC) is a well-recognised and commonly encountered upper respiratory tract disease in chickens. The aim of this study was to monitor aspects of the immune response of chickens infected with Avibacterium paragallinarum. Gene expression profiling of 30 genes was carried out for 11 chicken nasal area samples belonging to four groups, including one non-infected control group. For this purpose, 30 biomarker transcripts we...
Source: Veterinary Immunology and Immunopathology - June 24, 2015 Category: Veterinary Research Source Type: research

Distribution of highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in different stages of gestation sows HP-PRRSV distribution in gestation sows
Publication date: Available online 9 June 2015 Source:Veterinary Immunology and Immunopathology Author(s): Xiaofei Wang , Hongkai Qiu , Minxia Zhang , Xinna Cai , Yajin Qu , Dongfang Hu , Xiaomin Zhao , Enmin Zhou , Sidang Liu , Yihong Xiao Highly pathogenic PRRSV (HP-PRRSV) emerged in China in 2006 and caused severe reproductive losses, particularly in late-term sows. To determine whether these reproductive failures were related to the susceptibility of late-term sows to HP-PRRV, 60- and 90-days of gestation sows were infected with HP-PRRSV isolate TA-12 (GenBank accession HQ417620). A monoclonal antibody specific to th...
Source: Veterinary Immunology and Immunopathology - June 24, 2015 Category: Veterinary Research Source Type: research

In vivo porcine lipopolysaccharide inflammation models to study immunomodulation of drugs
Publication date: Available online 7 June 2015 Source:Veterinary Immunology and Immunopathology Author(s): H. Wyns , E. Plessers , P. De Backer , E. Meyer , S. Croubels Lipopolysaccharide (LPS), a structural part of the outer membrane of Gram-negative bacteria, is one of the most effective stimulators of the immune system and has been widely applied in pigs as an experimental model for bacterial infection. For this purpose, a variety of Escherichia coli serotypes, LPS doses, routes and duration of administration have been used. LPS administration induces the acute phase response (APR) and is associated with dramatic hemo...
Source: Veterinary Immunology and Immunopathology - June 24, 2015 Category: Veterinary Research Source Type: research

Benzimidazole Analogs Inhibit Respiratory Syncytial Virus G Protein Function
Publication date: Available online 24 June 2015 Source:Antiviral Research Author(s): Carrie W. Evans , Colm Atkins , Ashish Pathak , Brian E. Gilbert , James W. Noah Human Respiratory Syncytial Virus (hRSV) is a highly contagious Paramyxovirus that infects most children by age two, generating an estimated 75,000 – 125,000 hospitalizations in the U.S. annually. hRSV is the most common cause of bronchiolitis and pneumonia among infants and children under one year of age, with significant mortality among high-risk groups. A regulatory agency-approved vaccine is not available, and existing prophylaxis and therapies are lim...
Source: Antiviral Therapy - June 24, 2015 Category: Virology Source Type: research

Acute Respiratory Distress Syndrome With and Without Extracorporeal Membrane Oxygenation: A Score Matched Study
Conclusions Patients with ARDS who received ECMO treatment had higher inhospital survival rates than did those with a similar disease severity and at a similar age who did not receive ECMO. (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 24, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Early-term birth is a risk factor for wheezing in childhood: A cross-sectional population study
Early term–born (37-38 weeks' gestation) infants have increased respiratory morbidity during the neonatal period compared with full term–born (39-42 weeks' gestation) infants, but longer-term respiratory morbidity remains unclear. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - June 24, 2015 Category: Allergy & Immunology Authors: Martin O. Edwards, Sarah J. Kotecha, John Lowe, Louise Richards, W. John Watkins, Sailesh Kotecha Source Type: research

Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection
T J Braciale & J Sun (Source: Mucosal Immunology)
Source: Mucosal Immunology - June 24, 2015 Category: Allergy & Immunology Authors: S YaoL JiangE K MoserL B JewettJ WrightJ DuB ZhouS D DavisN L KruppT J BracialeJ Sun Source Type: research

Case of respiratory discomfort due to myositis after administration of nivolumab
(Source: The Journal of Dermatology)
Source: The Journal of Dermatology - June 24, 2015 Category: Dermatology Authors: Miri Yoshioka, Naotomo Kambe, Yosuke Yamamoto, Keisuke Suehiro, Hiroyuki Matsue Tags: Letter to the Editor Source Type: research

Disseminated infection caused by Emmonsia pasteuriana in a renal transplant recipient
Abstract Emmonsia pasteuriana is a thermally dimorphic fungus identified in very few human cases. Here, we report a case of a 43‐year‐old male renal transplant patient from China presenting with multiple painful skin eruptions on his head, nose and left thigh, later accompanied by respiratory failure. Histopathology of the biopsy collected from the left thigh upper ulcer and occipital nodule both demonstrated chronic inflammation with granuloma formation and yeast‐like elements. Emmonsia pasteuriana was cultured from two biopsy specimens and their identity was confirmed by sequencing of the rDNA internal transcribed...
Source: The Journal of Dermatology - June 24, 2015 Category: Dermatology Authors: Peiying Feng, Songchao Yin, Guoxing Zhu, Meirong Li, Benquan Wu, Yang Xie, Han Ma, Jun Zhang, Cailian Cheng, Gerrit Sijbrand Hoog, Chun Lu, Wei Lai Tags: Concise Communication Source Type: research

Bilateral vocal cord paralysis and hypothyroidism as presenting symptoms of Williams-Beuren syndrome; a case report
Williams-Beuren syndrome is a rare neurodevelopmental disorder caused by deletion of 1.5-1.8 Mb genes on chromosome 7q11.23. The syndrome was first described as a triad of supra-valvular aortic stenosis, mental retardation, and distinctive facial features. Our patient was referred due to audible inspiratory stridor when he was seven days old. Following endoscopy he was diagnosed with bilateral vocal cord paralysis and was eventually intubated due to respiratory de-compensation followed by tracheotomy. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 24, 2015 Category: ENT & OMF Authors: Ilana Koren, Ira Kessel, Avi Rotschild, Raanan Cohen-Kerem Tags: Case Report Source Type: research

Portable inhaled methoxyflurane is feasible and safe for colonoscopy in subjects with morbid obesity and/or obstructive sleep apnea
Conclusions: Compared with AADS, Penthrox is highly feasible and safe in patients with morbid obesity/OSA undergoing colonoscopy and is associated with fewer cardiorespiratory complications. Because of the advantages of this approach in regard to procedural time, recovery time, and cost benefit in comparison with AADS, further evaluation in a randomized trial is warranted.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: Endoscopy International Open)
Source: Endoscopy International Open - June 24, 2015 Category: Gastroenterology Authors: Nguyen, Nam Q.Toscano, LeanneLawrence, MatthewPhan, Vinh-AnSingh, RajvinderBampton, PeterFraser, Robert J.Holloway, Richard H.Schoeman, Mark N. Tags: Original article Source Type: research

Significant transplant-related mortality from respiratory virus infections within the first 100 days in children post hematopoietic stem cell transplantation
We report a study to evaluate incidence and outcome, short and long term, of RVI in children receiving HSCT. Between January 2000-December 2012, 844 patients underwent HSCT in SickKids. Allogeneic (allo=491), autologous (auto=353). Screening for causes of death in the first year post HSCT in the 844 patients, RVI as a cause of death was only evident in the first 100 days post HSCT. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - June 24, 2015 Category: Hematology Authors: Sakara Hutspardol, Mohammed Essa, Susan Richardson, Tal Schechter, Muhammad Ali, Joerg Krueger, Hisaki Fujii, R. Maarten Egeler, Adam Gassas Source Type: research

Treatment for disseminated intravascular coagulation in patients with acute and chronic leukemia.
CONCLUSIONS: Due to a lack of new RCTs, our conclusions in this Cochrane Review update are the same as the previous review version. We included four RCTs which reported mortality and bleeding data. It is not possible to determine whether human activated protein C, recombinant human soluble thrombomodulin, tranexamic acid and dermatan sulphate are effective or harmful for patients presenting with DIC related to acute or chronic leukemia. The quality of the evidence was low to very low. Therefore, prescription of these interventions for treating DIC in patients with acute and chronic leukemia can neither be supported nor rej...
Source: Cochrane Database of Systematic Reviews - June 24, 2015 Category: Journals (General) Authors: Martí-Carvajal AJ, Anand V, Solà I Tags: Cochrane Database Syst Rev Source Type: research

Exposure to traffic and lung function in adults: a general population cohort study
Conclusions High traffic exposure at the residential address was associated with lower than predicted FEV1 and FVC lung function compared with living further away in a large general population cohort. There were particular effects on women and individuals with obstructive disease. (Source: BMJ Open)
Source: BMJ Open - June 24, 2015 Category: Journals (General) Authors: Carlsen, H. K., Modig, L., Levinsson, A., Kim, J.-L., Toren, K., Nyberg, F., Olin, A.-C. Tags: Open access, Epidemiology, Occupational and environmental medicine, Public health, Respiratory medicine Research Source Type: research

A multicentre, randomised controlled, non-inferiority trial, comparing high flow therapy with nasal continuous positive airway pressure as primary support for preterm infants with respiratory distress (the HIPSTER trial): study protocol
Introduction High flow (HF) therapy is an increasingly popular mode of non-invasive respiratory support for preterm infants. While there is now evidence to support the use of HF to reduce extubation failure, there have been no appropriately designed and powered studies to assess the use of HF as primary respiratory support soon after birth. Our hypothesis is that HF is non-inferior to the standard treatment—nasal continuous positive airway pressure (NCPAP)— as primary respiratory support for preterm infants. Methods and analysis The HIPSTER trial is an unblinded, international, multicentre, randomised, non-inf...
Source: BMJ Open - June 24, 2015 Category: Journals (General) Authors: Roberts, C. T., Owen, L. S., Manley, B. J., Donath, S. M., Davis, P. G. Tags: Open access, Intensive care, Paediatrics, Respiratory medicine Protocol Source Type: research

Timing of elective delivery in gastroschisis: a decision and cost‐effectiveness analysis
ConclusionsFor pregnancies complicated by gastroschisis, the most cost‐effective timing of delivery is at 38 weeks. Few additional cases of RDS are caused for every one stillbirth or death within 1 year that was prevented with delivery at 37–38 weeks compared with at 39 weeks. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - June 24, 2015 Category: Radiology Authors: L. M. Harper, K. R. Goetzinger, J. R. Biggio, G. A. Macones Tags: Original Paper Source Type: research

Validation of a questionnaire for asthma case identification in pre‐schools in Latin America
ConclusionsWe have demonstrated the utility of a screening questionnaire for identifying pre‐school‐aged children who may benefit from further assessment for asthma. (Source: Respirology)
Source: Respirology - June 24, 2015 Category: Respiratory Medicine Authors: Luciano E. Busi, Peter D. Sly, Lidia Llancaman Tags: Original Article Source Type: research

Resistance profile and risk factors of drug resistant tuberculosis in the Baltic countries
The rates of multi- and extensively drug-resistant tuberculosis (X/MDRTB) in the Baltic countries are the highest within the European Union hampering recent achievements of national TB control programmes.We included all consecutive culture-confirmed X/MDRTB patients registered for treatment in 2009 in Latvia, Lithuania and Estonia into this multicenter case-control study. Cases were compared with randomly selected controls with non-MDRTB registered for treatment in the same year across these sites. (Source: Tuberculosis)
Source: Tuberculosis - June 24, 2015 Category: Respiratory Medicine Authors: Olga Ignatyeva, Yanina Balabanova, Vladyslav Nikolayevskyy, Ekaterina Koshkarova, Birute Radiulyte, Edita Davidaviciene, Vija Riekstina, Kadri Jaama, Manfred Danilovits, Cristina M. Popa, Francis A. Drobniewski Tags: Drug Discovery and Resistance Source Type: research

Feeding Difficulties in Children with Esophageal Atresia
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - June 24, 2015 Category: Respiratory Medicine Authors: Lisa Mahoney, Rachel Rosen Source Type: research

The effect of bronchodilators on forced vital capacity measurement in patients with idiopathic pulmonary fibrosis
Forced vital capacity (FVC) is a key measure of disease severity in patients with idiopathic pulmonary fibrosis (IPF) and is an important clinical trial endpoint. We hypothesize that reversible airflow limitation co-exists in a subgroup of patients with IPF, and that bronchodilator use will improve the performance characteristics of FVC. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 24, 2015 Category: Respiratory Medicine Authors: Deborah Assayag, Eric Vittinghoff, Christopher J. Ryerson, Elisabetta Cocconcelli, Roberto Tonelli, Xiaowen Hu, Brett M. Elicker, Jeffrey A. Golden, Kirk D. Jones, Talmadge E. King, Laura L. Koth, Joyce S. Lee, Brett Ley, Anthony K. Shum, Paul J. Wolters, Source Type: research

The Association Between Seasonal Asthma Exacerbations and Viral Respiratory Infections in a Pediatric Population Receiving Inhaled Corticosteroid Therapy With or Without Long-Acting Beta-Adrenoceptor Agonist: a Randomized Study
A seasonal peak in asthma exacerbations in the fall has previously been reported. The association between fall exacerbations and viral respiratory tract infections (RTI) remains uncertain. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 24, 2015 Category: Respiratory Medicine Authors: Charlene M. Prazma, James E. Gern, Steven F. Weinstein, Barbara A. Prillaman, David A. Stempel Tags: Clinical Trial Paper Source Type: research

Timing and Duration of Traffic-Related Air Pollution Exposure and the Risk for Childhood Wheeze and Asthma.
CONCLUSIONS: Early-life exposure to TRAP is associated with increased risk for persistent wheezing, but only long-term exposure to high levels of TRAP throughout childhood was associated with asthma development. PMID: 26106807 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 24, 2015 Category: Respiratory Medicine Authors: Brunst KJ, Ryan PH, Brokamp C, Bernstein D, Reponen T, Lockey J, Khurana Hershey GK, Levin L, Grinshpun SA, LeMasters G Tags: Am J Respir Crit Care Med Source Type: research

Lack of Transcription Factor p53 Exacerbates Elastase-induced Emphysema in Mice.
CONCLUSION: These findings provide evidence that p53-/- mice and WT mice grafted with p53 -/- myeloid cells are more prone to develop elastase-induced emphysema, supporting a protective role of p53, and more precisely p53 expressed in macrophages, against emphysema development. The pivotal role played by macrophages in this phenomenon may involve the MMP12-TNFα pathway. PMID: 26106979 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - June 24, 2015 Category: Respiratory Medicine Authors: Chrusciel S, Zysman M, Caramelle P, Tiendrebeogo A, Baskara I, Le Gouvello S, Chabot F, Giraudier S, Boczkowski J, Boyer L Tags: Am J Respir Cell Mol Biol Source Type: research

Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and endoplasmic reticulum.
Abstract Ketamine abusers develop severe lower urinary tract symptoms. The major aims of our study were to elucidate ketamine-induced ulcerative cystitis and bladder apoptosis in association with oxidative stress mediated by mitochondria and endoplasmic reticulum (ER). Sprague-Dawley rats were distributed into three different groups, which received saline, or ketamine for a period of 14 days or 28 days, respectively. The double-labeled immunofluorescence studies were applied to investigate tight junction proteins for urothelial barrier functions. The terminal deoxynucleotidyl transferase dUTP nick-end labeling assa...
Source: Am J Physiol Renal P... - June 24, 2015 Category: Urology & Nephrology Authors: Liu KM, Chuang SM, Long CY, Lee YL, Wang CC, Lu MC, Lin RJ, Lu JH, Jang MY, Wu WJ, Ho WT, Juan YS Tags: Am J Physiol Renal Physiol Source Type: research

Case report of equine influenza in Italy, in 2014
This study reports the isolation and genetic characterization of an EI virus (EIV) from a stable of thoroughbred racehorses. The episode was characterised by fever and dry cough and involved eleven, two-three year old, flu vaccinated horses, four of which were found positive for EIV, by reverse-transcriptase Real Time PCR (RRT-PCR) targeting the matrix gene. (Source: Journal of Equine Veterinary Science)
Source: Journal of Equine Veterinary Science - June 24, 2015 Category: Veterinary Research Authors: Gian Luca Autorino, Raffaele Frontoso, Antonella Cersini, Giuseppe Manna, Armando Damiani, Maria Teresa Scicluna Tags: Short Communication Source Type: research

Pulmonoscopy of Snakes
Pulmonoscopy is a practical diagnostic tool for investigating respiratory diseases in snakes. Two different approaches exist for pulmonoscopy, tracheal and transcutaneous. The access to the proximal or distal lung is limited by the length and diameter of the endoscope when using the tracheal approach. The transcutaneous approach allows direct evaluation of the lung and distal trachea through the air sac. Both of the methods are safe, and specific contraindications for pulmonoscopy in snakes are not known except for any anesthesia contraindication. (Source: Veterinary Clinics of North America: Exotic Animal Practice)
Source: Veterinary Clinics of North America: Exotic Animal Practice - June 24, 2015 Category: Veterinary Research Authors: Zdenek Knotek, Vladimir Jekl Source Type: research

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice.
Abstract The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in smoke-related lung carcinogenesis is still controversial. We have developed and validated a murine model for evaluating the tumorigenicity of mainstream cigarette smoke (MCS) and its modulation by chemopreventive agents. In the present study, the protective effects of the nonselective cyclooxygenase inhibitors aspirin and naproxen were investigated by using a total of 277 Swiss H neonatal mice of both genders. Groups of mice were exposed whole-body to MCS during the first 4 months of life, followed by an additional 3.5 months in filtered air in...
Source: Archives of Toxicology - June 24, 2015 Category: Toxicology Authors: Balansky R, Ganchev G, Iltcheva M, Micale RT, La Maestra S, D'Oria C, Steele VE, De Flora S Tags: Arch Toxicol Source Type: research

Nuclear respiratory factor 2 induces SIRT3 expression
Summary The mitochondrial deacetylase SIRT3 regulates several important metabolic processes. SIRT3 is transcriptionally upregulated in multiple tissues during nutrient stresses such as dietary restriction and fasting, but the molecular mechanism of this induction is unclear. We conducted a bioinformatic study to identify transcription factor(s) involved in SIRT3 induction. Our analysis identified an enrichment of binding sites for nuclear respiratory factor 2 (NRF‐2), a transcription factor known to play a role in the expression of mitochondrial genes, in the DNA sequences of SIRT3 and genes with closely correlated expre...
Source: Aging Cell - June 24, 2015 Category: Cytology Authors: F. Kyle Satterstrom, William R. Swindell, Gaëlle Laurent, Sejal Vyas, Martha L. Bulyk, Marcia C. Haigis Tags: Original Article Source Type: research

Differential determination of plasticizers and organophosphorus flame retardants in residential indoor air in Japan.
In this study, we measured 54 compounds, including plasticizers (phthalates, adipates, and others) and organophosphorus flame retardants, in indoor air samples from the living rooms of 21 dwellings in 11 prefectures across Japan. For sampling, we used a four-stage air sampler (multi-nozzle cascade impactor) equipped with three quartz fiber filters to capture chemical particulates in three size ranges (<2.5, 2.5-10, and >10 μm) and a C18 solid-phase extraction disk to capture chemicals that exist in a gas phase in indoor air. Each of the chemicals in the three particulate phases and single gas phase was extracted by...
Source: Environmental Science and Pollution Research International - June 24, 2015 Category: Environmental Health Authors: Takeuchi S, Tanaka-Kagawa T, Saito I, Kojima H, Jin K, Satoh M, Kobayashi S, Jinno H Tags: Environ Sci Pollut Res Int Source Type: research

Resistance profile and risk factors of drug resistant tuberculosis in the Baltic countries
The rates of multi- and extensively drug-resistant tuberculosis (X/MDRTB) in the Baltic countries are the highest within the European Union hampering recent achievements of national TB control programmes.We included all consecutive culture-confirmed X/MDRTB patients registered for treatment in 2009 in Latvia, Lithuania and Estonia into this multicenter case–control study. Cases were compared with randomly selected controls with non-MDRTB registered for treatment in the same year across these sites. (Source: Tuberculosis)
Source: Tuberculosis - June 24, 2015 Category: Respiratory Medicine Authors: Olga Ignatyeva, Yanina Balabanova, Vladyslav Nikolayevskyy, Ekaterina Koshkarova, Birute Radiulyte, Edita Davidaviciene, Vija Riekstina, Kadri Jaama, Manfred Danilovits, Cristina M. Popa, Francis A. Drobniewski Tags: Drug discovery and resistance Source Type: research

Benzimidazole analogs inhibit respiratory syncytial virus G protein function.
Abstract Human respiratory syncytial virus (hRSV) is a highly contagious Paramyxovirus that infects most children by age two, generating an estimated 75,000-125,000 hospitalizations in the U.S. annually. hRSV is the most common cause of bronchiolitis and pneumonia among infants and children under 1year of age, with significant mortality among high-risk groups. A regulatory agency-approved vaccine is not available, and existing prophylaxis and therapies are limited to use in high-risk pediatric patients; thus additional therapies are sorely needed. Here, we identify a series of benzimidazole analogs that inhibit hRS...
Source: Antiviral Research - June 24, 2015 Category: Virology Authors: Evans CW, Atkins C, Pathak A, Gilbert BE, Noah JW Tags: Antiviral Res Source Type: research

RIFM fragrance ingredient safety assessment, Isophytol, CAS Registry Number 505-32-8.
Abstract The use of this material under current use conditions is supported by the existing information This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose toxicity was determined to have the most conservative systemic exposure derived NO[A]EL of 25 mg/kg/day, based on an OECD 415 gavage one-generation reproductive toxicity study in rats, that resulted in a MOE of 1923 considering 100% absorption from skin contact and inhalation. A MO...
Source: Food and Chemical Toxicology - June 24, 2015 Category: Food Science Authors: Api AM, Belsito D, Bhatia S, Bruze M, Calow P, Dagli ML, Dekant W, Fryer AD, Kromidas L, La Cava S, Lalko JF, Lapczynski A, Liebler DC, Politano VT, Ritacco G, Salvito D, Schultz TW, Shen J, Sipes IG, Wall B, Wilcox DK Tags: Food Chem Toxicol Source Type: research

Exposure to arginine analog canavanine induces aberrant mitochondrial translation products, mitoribosome stalling, and instability of the mitochondrial proteome.
Abstract Impairment of mitochondrial protein homeostasis disrupts mitochondrial function and causes human diseases and aging, but the molecular mechanisms of protein synthesis and quality control in mammalian mitochondria are not fully understood. Here we demonstrate in human cells that misincorporation of an arginine analogue, canavanine, during mitochondrial protein synthesis, induced aberrant translation products and destabilized the mtDNA-encoded proteome, leading to loss of mitochondrial respiratory chain complexes. Furthermore, in the presence of a high concentration of canavanine, mitoribosome stalling could...
Source: The International Journal of Biochemistry and Cell Biology - June 24, 2015 Category: Biochemistry Authors: Konovalova S, Hilander T, Loayza-Puch F, Rooijers K, Agami R, Tyynismaa H Tags: Int J Biochem Cell Biol Source Type: research

Deoxynivalenol (DON) naturally contaminated feed impairs the immune response induced by porcine reproductive and respiratory syndrome virus (PRRSV) live attenuated vaccine.
The objective of this study was to determine the impact of DON naturally contaminated feed on the immune response generated following vaccination with PRRSV live attenuated vaccine. Eighteen pigs were randomly divided into three experimental groups of 6 animals based on DON content of the diets (0, 2.5 and 3.5mg DON/kg). They were fed these rations one week prior to the vaccination and for all the duration of the immune response evaluation. All pigs were vaccinated intra-muscularly with one dose of Ingelvac(®) PRRSV modified live vaccine (MLV). Blood samples were collected at day -1, 6, 13, 20, 27 and 35 post vaccination ...
Source: Vaccine - June 24, 2015 Category: Allergy & Immunology Authors: Savard C, Gagnon CA, Chorfi Y Tags: Vaccine Source Type: research

Acute Respiratory Distress Syndrome With and Without Extracorporeal Membrane Oxygenation: A Score Matched Study.
CONCLUSIONS: Patients with ARDS who received ECMO treatment had higher inhospital survival rates than did those with a similar disease severity and at a similar age who did not receive ECMO. PMID: 26116481 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 24, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tsai HC, Chang CH, Tsai FC, Fan PC, Juan KC, Lin CY, Yang HY, Kao KC, Fang JT, Yang CW, Chang SW, Chen YC Tags: Ann Thorac Surg Source Type: research

Is surgical plication necessary in diaphragm eventration?
CONCLUSION: Researchers of this study believe that more distinctive decisions need to be taken while identifying patients for surgery in unilateral diaphragm eventrations, especially in the adult patient group; surgical option should be used for cases in which the eventrated diaphragm results in mediastinal shift and respiratory failure. PMID: 26117205 [PubMed - as supplied by publisher] (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - June 24, 2015 Category: Surgery Authors: Özkan S, Yazici Ü, Aydin E, Karaoğlanoğlu N Tags: Asian J Surg Source Type: research

Bilateral vocal cord paralysis and hypothyroidism as presenting symptoms of Williams–Beuren syndrome: A case report
Williams–Beuren syndrome is a rare neurodevelopmental disorder caused by deletion of 1.5–1.8Mb genes on chromosome 7q11.23. The syndrome was first described as a triad of supra-valvular aortic stenosis, mental retardation, and distinctive facial features. Our patient was referred due to audible inspiratory stridor when he was seven days old. Following endoscopy he was diagnosed with bilateral vocal cord paralysis and was eventually intubated due to respiratory de-compensation followed by tracheotomy. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - June 24, 2015 Category: ENT & OMF Authors: Ilana Koren, Ira Kessel, Avi Rotschild, Raanan Cohen-Kerem Tags: Case Report Source Type: research

Tuberous Sclerosis Complex: State-of-the-Art Review with a Focus on Pulmonary Involvement
Abstract Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous disease with high phenotypic variability. The incidence is approximately one in 5000–10,000 births. TSC is characterized by widespread hamartomas and benign or rarely malignant neoplasms affecting various organs, most commonly the brain, skin, retinas, kidneys, heart, and lungs. The wide range of organs affected reflects the roles of TSC1 and TSC2 genes in the regulation of cell proliferation and differentiation. Clinical diagnostic criteria are important because genetic testing does not identify the mutation in up to 25 % of pati...
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Lung (DIPNECH): Current Best Evidence
Abstract Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is recognized as a preneoplastic condition by the World Health Organization. We reviewed our experience with 30 patients and performed a systematic review of the English literature to collect best evidence on the clinical features and disease course in 169 additional patients. Some patients presented with one or more carcinoid tumors associated with multiple small pulmonary nodules on imaging studies and showed DIPNECH as a somewhat unexpected pathologic finding. Others presented with multiple small pulmonary nodules that raised su...
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

A Giant Cell Tumor Arising from the Anterior Costal Arc in a Young Man
(Source: Lung)
Source: Lung - June 23, 2015 Category: Respiratory Medicine Source Type: research

Levodropropizine for treating cough in adult and children: a meta-analysis of published studies.
CONCLUSIONS: This analysis indicates that levodropropizine is an effective antitussive drug in children and adults, with statistically significant better overall efficacy outcomes vs. central antitussive drugs (codeine, cloperastine, dextromethorphan) in terms of reducing cough intensity and frequency, and nocturnal awakenings. This result further reinforces the favorable benefit/risk profile of levodropropizine in the management of cough. The efficacy of levodropropizine in the treatment of cough in children and adults is higher than that of the common centrally-acting anti-tussive. PMID: 26097707 [PubMed - as supplie...
Source: Respiratory Care - June 23, 2015 Category: Respiratory Medicine Authors: Zanasi A, Lanata L, Fontana G, Saibene F, Dicpinigaitis P, De Blasio F Tags: Multidiscip Respir Med Source Type: research

The Case Files: Solid Organ Injury and Hemorrhagic Shock after a Fall
By Charles Burtis, MD; Ann Haynes, MD & Andrew King, MD  A 59-year-old woman presented to the emergency department complaining of worsening abdominal pain and distension as well as four episodes of syncope and lightheadedness. The patient reported a past medical history of hypertension and hypothyroidism, but denied other comorbidities. The patient reported that she was walking her dog the previous night when the dog bolted forward, causing her to lose her balance and fall forward. The patient reported that she was able to tuck into a ball and roll, sustaining minor trauma only to her right side. She denied any hea...
Source: The Case Files - June 23, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
The PLA2G6 gene encodes a group VIA calcium-independent phospholipase A2 beta enzyme that selectively hydrolyses glycerophospholipids to release free fatty acids. Mutations in PLA2G6 have been associated with disorders such as infantile neuroaxonal dystrophy, neurodegeneration with brain iron accumulation type II and Karak syndrome. More recently, PLA2G6 was identified as the causative gene in a subgroup of patients with autosomal recessive early-onset dystonia-parkinsonism. Neuropathological examination revealed widespread Lewy body pathology and the accumulation of hyperphosphorylated tau, supporting a link between PLA2G...
Source: Brain - June 23, 2015 Category: Neurology Authors: Kinghorn, K. J., Castillo-Quan, J. I., Bartolome, F., Angelova, P. R., Li, L., Pope, S., Cocheme, H. M., Khan, S., Asghari, S., Bhatia, K. P., Hardy, J., Abramov, A. Y., Partridge, L. Tags: Original Articles Source Type: research