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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

Phrenic Nerve Conduction Abnormalities Correlate with Diaphragmatic Descent in Chronic Obstructive Pulmonary Disease
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Differences in Adherence to Common Inhaled Medications in COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Relationship between Troponin Elevation, Cardiovascular History and Adverse Events in Patients with acute exacerbation of COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Utility Scores In Patients With Oxygen-Dependent COPD: A Case-Control Study
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

The Use of Pulse Oximetry to Determine Hypoxemia in Acute Exacerbations of COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Patient Anxiety and Depression Moderate the Effects of Increased Self-management Knowledge on Physical Activity: A Secondary Analysis of a Randomised Controlled Trial on Health-Mentoring in COPD
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Inhaled Corticosteroids for Chronic Obstructive Pulmonary Disease—The Shifting Treatment Paradigm
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Distinct Trajectories of Physical Activity Among Patients with COPD During and After Pulmonary Rehabilitation
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Prophylaxis for Pneumocystis jiroveci pneumonia: is it a necessity in pulmonary patients on high-dose, chronic corticosteroid therapy without AIDS?
Expert Review of Respiratory Medicine, Volume 9, Issue 2, Page 171-181, April 2015. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - March 16, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Risk of cancer among HIV-infected patients from a population-based nested case¿control study: implications for cancer prevention
Conclusions: Patients with HIV infection are at increased risk for several specific cancers. Our results support the implementation of an active and accelerated cancer screening schedule for patients with HIV infection to increase their life span. (Source: BMC Cancer)
Source: BMC Cancer - March 16, 2015 Category: Cancer & Oncology Authors: Chang-Hua ChenChih-Yuan ChungLi-Hsuan WangChe LinHsiu-Li LinHsiu-Chen Lin Source Type: research

18F‐FDG uptake in focal organising pneumonia mimicking bronchial carcinoma
ConclusionFocal OP is a discrete form of OP that is associated with unifocal lesions on radiological images, and it can easily mimic lung cancer because of positivity on PET scans. There are no specific findings of PET scan for the diagnosis of OP. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 16, 2015 Category: Respiratory Medicine Authors: Ayse Baha, Fatma Yildirim, Nurdan Kokturk, Umit Ozgur Akdemir, Sedat Demircan, Haluk Turktas Tags: Original Article Source Type: research

Respiratory and inflammatory responses to short-term exposure to traffic-related air pollution with and without moderate physical activity
Conclusions In a healthy population, intermittent moderate PA has beneficial effects on pulmonary function even when performed in a highly polluted environment. This study also suggests that particulate air pollution is inducing pulmonary and systemic inflammatory responses. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - March 16, 2015 Category: Occupational Health Authors: Kubesch, N. J., de Nazelle, A., Westerdahl, D., Martinez, D., Carrasco-Turigas, G., Bouso, L., Guerra, S., Nieuwenhuijsen, M. J. Tags: Air pollution, air quality, Other exposures Environment Source Type: research

Trends in incidence of occupational asthma, contact dermatitis, noise-induced hearing loss, carpal tunnel syndrome and upper limb musculoskeletal disorders in European countries from 2000 to 2012
Conclusions This is the first direct comparison of trends in OD within Europe and is consistent with a positive impact of European initiatives addressing exposures relevant to asthma and contact dermatitis. Taking a more flexible approach allowed comparisons of surveillance data between and within countries without harmonisation of data collection methods. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - March 16, 2015 Category: Occupational Health Authors: Stocks, S. J., McNamee, R., van der Molen, H. F., Paris, C., Urban, P., Campo, G., Sauni, R., Martinez Jarreta, B., Valenty, M., Godderis, L., Miedinger, D., Jacquetin, P., Gravseth, H. M., Bonneterre, V., Telle-Lamberton, M., Bensefa-Colas, L., Faye, S., Tags: Editor's choice, Allergy, asthma, Hearing-related, Musculoskeletal, Respiratory Methodology Source Type: research

Twenty years of SHIELD: decreasing incidence of occupational asthma in the West Midlands, UK?
Conclusions Reporter fatigue and increasing under-recognition of OA are both factors which contribute to the apparent fall in incidence of OA in the West Midlands. There is a future need for interventions that enable health professionals to identify potential cases of OA in the workplace and in healthcare settings. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - March 16, 2015 Category: Occupational Health Authors: Walters, G. I., Kirkham, A., McGrath, E. E., Moore, V. C., Robertson, A. S., Burge, P. S. Tags: Allergy, asthma, Respiratory Practice Source Type: research

A Novel TAZ Gene Mutation and Mosaicism in a Polish Family with Barth Syndrome
Summary Barth syndrome (BTHS) is an X‐linked recessive disease primarily affecting males. Clinically, the disease is characterized by hypertrophic or dilated cardiomyopathy, skeletal myopathy, chronic/cyclic neutropenia, 3‐methylglutaconic aciduria, growth retardation and respiratory chain dysfunction. It is caused by mutations in the TAZ gene coding for the tafazzin protein which is responsible for cardiolipin remodeling. In this work, we present a novel pathogenic TAZ mutation c.83T>A, p.Val28Glu, found in mosaic form in almost all female members of a Polish family. Sanger sequencing of DNA from peripheral blood a...
Source: Annals of Human Genetics - March 16, 2015 Category: Genetics & Stem Cells Authors: Barbara Zapała, Teresa Płatek, Iwona Wybrańska Tags: Short Communication Source Type: research

A simple prognostic index based on admission vital signs data among patients with sepsis in a resource-limited setting
IntroductionIn sub-Saharan Africa, vital signs are a feasible option for monitoring critically ill patients. We assessed how admission vital signs data predict in-hospital mortality among patients with sepsis. In particular, we assessed whether vital signs data can be incorporated into a prognostic index with reduced segmentation in the values of included variables. Methods: Subjects were patients with sepsis hospitalized in Uganda, who participated in two cohort studies. Using restricted cubic splines of admission vital signs data, we predicted probability of in-hospital death in the development cohort and used this infor...
Source: Critical Care - March 16, 2015 Category: Intensive Care Authors: Stephen AsiimweAmir AbdallahRichard Ssekitoleko Source Type: research

Extracorporeal gas exchange for acute respiratory failure in adult patients: a systematic review
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2015 and co-published as a series in Critical Care. Other articles in the series can be found online at http://ccforum.com/series/annualupdate2015. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - March 16, 2015 Category: Epidemiology Authors: Matthieu SchmidtCarol HodgsonAlain Combes Source Type: research

Comparative Cytotoxicity of Glycyrrhiza glabra Roots from Different Geographical Origins Against Immortal Human Keratinocyte (HaCaT), Lung Adenocarcinoma (A549) and Liver Carcinoma (HepG2) Cells
Glycyrrhiza glabra L. (Fabaceae), commonly known as ‘liquorice’, is a well‐known medicinal plant. Roots of this plant have long been used as a sweetening and flavouring agent in food and pharmaceutical products, and also as a traditional remedy for cough, upper and lower respiratory ailments, kidney stones, hepatitis C, skin disorder, cardiovascular diseases, diabetes, gastrointestinal ulcers and stomach ache. Previous pharmacological and clinical studies have revealed its antitussive, antiinflammatory, antiviral, antimicrobial, antioxidant, immunomodulatory, hepatoprotective and cardioprotective properties. While gl...
Source: Phytotherapy Research - March 16, 2015 Category: Biochemistry Authors: Norazah Basar, Olayinka Ayotunde Oridupa, Kenneth J. Ritchie, Lutfun Nahar, Nashwa Mostafa M. Osman, Angela Stafford, Habibjon Kushiev, Asuman Kan, Satyajit D. Sarker Tags: Short Communication Source Type: research

Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ
by Karl J. Staples, Ben Nicholas, Richard T. McKendry, C. Mirella Spalluto, Joshua C. Wallington, Craig W. Bragg, Emily C. Robinson, Kirstin Martin, Ratko Djukanović, Tom M. A. Wilkinson Lung macrophages are an important defence against respiratory viral infection and recent work has demonstrated that influenza-induced macrophage PDL1 expression in the murine lung leads to rapid modulation of CD8+ T cell responses via the PD1 receptor. This PD1/PDL1 pathway may downregulate acute inflammatory responses to prevent tissue damage. The aim of this study was to investigate the mechanisms of PDL1 regulation by human macrophage...
Source: PLoS One - March 16, 2015 Category: Biomedical Science Authors: Karl J. Staples et al. Source Type: research

Early pulmonary events of nose‐only water pipe (shisha) smoking exposure in mice
Abstract Water pipe smoking (WPS) is increasing in popularity and prevalence worldwide. Convincing data suggest that the toxicants in WPS are similar to that of cigarette smoke. However, the underlying pathophysiologic mechanisms related to the early pulmonary events of WPS exposure are not understood. Here, we evaluated the early pulmonary events of nose‐only exposure to mainstream WPS generated by commercially available honey flavored “moasel” tobacco. BALB/c mice were exposed to WPS 30 min/day for 5 days. Control mice were exposed using the same protocol to atmospheric air only. We measured airway resistance usi...
Source: Physiological Reports - March 16, 2015 Category: Physiology Authors: Abderrahim Nemmar, Ahmed Al Hemeiri, Naser Al Hammadi, Priya Yuvaraju, Sumaya Beegam, Javed Yasin, Mohamed Elwasila, Badreldin H. Ali, Ernest Adeghate Tags: Original Research Source Type: research

Effect of acute acid‐base disturbances on the phosphorylation of phospholipase C‐γ1 and Erk1/2 in the renal proximal tubule
Abstract The renal proximal tubule (PT) plays a major role in whole‐body pH homeostasis by secreting H+ into the tubule lumen. Previous work demonstrated that PTs respond to basolateral changes in [CO2] and [] by appropriately altering H+ secretion—responses blocked by the ErbB inhibitor PD168393, or by eliminating signaling through AT1 angiotensin receptors. In the present study, we analyze phosphorylation of three downstream targets of both ErbBs and AT1: phospholipase C‐γ1 (PLC‐γ1), extracellular‐regulated kinase 1 (Erk1), and Erk2. We expose rabbit PT suspensions for 5 and 20 min to our control (Ctrl) cond...
Source: Physiological Reports - March 16, 2015 Category: Physiology Authors: Lara A. Skelton, Walter F. Boron Tags: Original Research Source Type: research

The caspase inhibitor zVAD increases lung inflammation in pneumovirus infection in mice
Abstract Severe respiratory syncytial virus (RSV) disease is a frequent cause of acute respiratory distress syndrome (ARDS) in young children, and is associated with marked lung epithelial injury and neutrophilic inflammation. Experimental studies on ARDS have shown that inhibition of apoptosis in the lungs reduces lung epithelial injury. However, the blockade of apoptosis in the lungs may also have deleterious effects by hampering viral clearance, and importantly, by enhancing or prolonging local proinflammatory responses. The aim of this study was to determine the effect of the broad caspase inhibitor Z‐VAD(OMe)‐FMK ...
Source: Physiological Reports - March 16, 2015 Category: Physiology Authors: Elske Berg, Suzanne M. Bal, Maria T. Kuipers, Gustavo Matute‐Bello, René Lutter, Albert P. Bos, Job B. M. Woensel, Reinout A. Bem Tags: Original Research Source Type: research

Sensors, Vol. 15, Pages 6383-6398: Assessment of Human Respiration Patterns via Noncontact Sensing Using Doppler Multi-Radar System
Human respiratory patterns at chest and abdomen are associated with both physical and emotional states. Accurate measurement of the respiratory patterns provides an approach to assess and analyze the physical and emotional states of the subject persons. Not many research efforts have been made to wirelessly assess different respiration patterns, largely due to the inaccuracy of the conventional continuous-wave radar sensor to track the original signal pattern of slow respiratory movements. This paper presents the accurate assessment of different respiratory patterns based on noncontact Doppler radar sensing. This paper eva...
Source: Sensors - March 16, 2015 Category: Biotechnology Authors: Changzhan GuChangzhi Li Tags: Article Source Type: research

Remarks on the evolution of the avian sternum, dinosaur gastralia, and their functional significance for the respiratory apparatus
Publication date: March 2015 Source:Zoologischer Anzeiger - A Journal of Comparative Zoology, Volume 255 Author(s): Markus Lambertz , Steven F. Perry The sternum is a central part of the avian skeleton and, among other functions, it serves as a key element of their locomotor apparatus by providing the origin site for the primary flight musculature. Understanding the evolutionary history of the sternum is critical for understanding the origin of active flight: a fundamental characteristic of one of the most diverse extant tetrapod lineages. It recently has been proposed that the sternal elements in extinct basal bird radi...
Source: A Journal of Comparative Zoology - March 16, 2015 Category: Zoology Source Type: research

Chronic rhinosinusitis and cystic fibrosis: the interaction between sinus bacteria and mucosal immunity
ConclusionIntramucosal bacteria exist within the sinus mucosa of patients with CF, and in significantly greater numbers than in idiopathic CRS patients. We speculate that intramucosal microcolonies may also exist in the lower respiratory tract mucosa in CF and play a role in disease recalcitrance. (Source: International Forum of Allergy and Rhinology)
Source: International Forum of Allergy and Rhinology - March 16, 2015 Category: Allergy & Immunology Authors: Raymond J.T. Kim, Lydia Park, Andrew J. Wood, Tary Yin, Ravi Jain, Richard G. Douglas Tags: ORIGINAL ARTICLE Source Type: research

Factors Associated With Oxyhemoglobin Desaturation During Rapid Sequence Intubation in a Pediatric Emergency Department: Findings From Multivariable Analyses of Video Review Data
ConclusionsFor children 24 months of age or younger undergoing RSI in a PED, respiratory indication for intubation, esophageal intubation, and duration of laryngoscopy (both individual and cumulative) were associated with desaturation; the number of attempts was not. Interventions to limit attempt duration in the youngest children may improve the safety of RSI. (Source: Academic Emergency Medicine)
Source: Academic Emergency Medicine - March 16, 2015 Category: Emergency Medicine Authors: Andrea S. Rinderknecht, Matthew R. Mittiga, Jareen Meinzen‐Derr, Gary L. Geis, Benjamin T. Kerrey Tags: Original Contribution Source Type: research

The Prevalence and Diagnostic Utility of Systemic Inflammatory Response Syndrome Vital Signs in a Pediatric Emergency Department
ConclusionsSystemic inflammatory response syndrome vital signs are common among medical pediatric patients presenting to an ED, and critical illness is rare. The majority of patients with SIRS vital signs were discharged without IV therapy and without readmission. Patients with SIRS vital signs had a statistically significant increased risk of critical care requirement, ED IV treatment, ED laboratory tests, admission, and readmission. However, SIRS vital sign criteria did not identify the majority of patients with mortality or need for critical care. SIRS vital signs had low sensitivity for critical illness, making it poor...
Source: Academic Emergency Medicine - March 16, 2015 Category: Emergency Medicine Authors: Halden F. Scott, Sara J. Deakyne, Jason M. Woods, Lalit Bajaj Tags: Original Contribution Source Type: research

Increased delayed mortality in patients with acute‐on‐chronic liver failure who have prior decompensation
ConclusionACLF patients with or without PD had comparable short‐term prognosis but differential 1‐year mortality. ACLF patients with PD were distinct from those without PD in age, types of acute insults, severity of hepatic damage, and distribution of complications, and the former group was characterized by increased delayed mortality. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - March 16, 2015 Category: Gastroenterology Authors: Yu Shi, Ming‐hua Zheng, Ying Yang, Wu Wei, Qiao Yang, Airong Hu, Yaoren Hu, Yihua Wu, Huadong Yan Tags: Hepatology Source Type: research

Polysomnography for the diagnosis of sleep disordered breathing in children under 2 years of age
ConclusionChildren <6 months of age appear to represent a distinct group with respect to PSG. Experienced sleep physicians appear to incorporate age and respiratory event frequently when determining the presence of SDB. Further information about clinical significance of apnea in infancy is required, assisted by identification of factors that sleep physicians use to identify SDB in children <6 months of age. Pediatr Pulmonol. © 2015 The Authors. Pediatric Pulmonology published by Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 16, 2015 Category: Respiratory Medicine Authors: Kristie L. DeHaan, Chris Seton, Dominic A. Fitzgerald, Karen A Waters, Joanna E. MacLean Tags: Original Article: Sleep & Breathing Source Type: research

Expression of Mitochondria‐Associated Genes (PPARGC1A, NRF‐1, BCL‐2 and BAX) in Follicular Development and Atresia of Goat Ovaries
Contents Most follicles undergo atresia during the developmental process. Follicular atresia is predominantly regulated by apoptosis of granulosa cells, but the mechanism underlying apoptosis via the mitochondria‐dependent apoptotic pathway is unclear. We aimed to investigate whether the mitochondria‐associated genes peroxisome proliferator‐activated receptor‐gamma, coactivator1‐alpha (PPARGC1A), nuclear respiratory factor‐1 (NRF‐1), B‐cell CLL/lymphoma 2 (BCL‐2) and BCL2‐associated X protein (BAX) played a role in follicular atresia through this pathway. The four mitochondria‐associated proteins (PGC...
Source: Reproduction in Domestic Animals - March 16, 2015 Category: Reproduction Medicine Authors: G Zhang, Y Wan, Y Zhang, S Lan, R Jia, Z Wang, Y Fan, F Wang Tags: Original Article Source Type: research

Leukotriene inhibitors for bronchiolitis in infants and young children.
CONCLUSIONS: The current evidence does not allow definitive conclusions to be made about the effects of leukotriene inhibitors on length of hospital stay and clinical severity score in infants and young children with bronchiolitis. The quality of the evidence was low due to inconsistency (unexplained high levels of statistical heterogeneity) and imprecision arising from small sample sizes and wide confidence intervals, which did not rule out a null effect or harm. Data on symptom-free days and incidence of recurrent wheezing were from single studies only. Further large studies are required. We identified one registered ong...
Source: Cochrane Database of Systematic Reviews - March 16, 2015 Category: Journals (General) Authors: Liu F, Ouyang J, Sharma AN, Liu S, Yang B, Xiong W, Xu R Tags: Cochrane Database Syst Rev Source Type: research

SIRT1/PGC1α dependent increase in oxidative phosphorylation supports chemotherapy resistance of colon cancer.
CONCLUSION: Chemotherapy of colorectal tumors induces a SIRT1/PGC1α-dependent increase in OXPHOS that promotes tumor survival during treatment. This phenomenon is also observed in chemotherapy-exposed resected liver metastases, strongly suggesting that chemotherapy induces long-lasting changes in tumor metabolism that potentially interfere with drug efficacy. In conclusion, we propose a novel mechanism of chemotherapy resistance that may be clinically relevant and therapeutically exploitable. PMID: 25779952 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)
Source: Clinical Cancer Research - March 16, 2015 Category: Cancer & Oncology Authors: Vellinga TT, Borovski T, de Boer VC, Fatrai S, van Schelven S, Trumpi K, Verheem A, Snoeren N, Emmink BL, Koster J, Borel Rinkes IH, Kranenburg O Tags: Clin Cancer Res Source Type: research

Factors Associated With Oxyhemoglobin Desaturation During Rapid Sequence Intubation in a Pediatric Emergency Department: Findings From Multivariable Analyses of Video Review Data.
CONCLUSIONS: For children 24 months of age or younger undergoing RSI in a PED, respiratory indication for intubation, esophageal intubation, and duration of laryngoscopy (both individual and cumulative) were associated with desaturation; the number of attempts was not. Interventions to limit attempt duration in the youngest children may improve the safety of RSI. PMID: 25779855 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - March 16, 2015 Category: Emergency Medicine Authors: Rinderknecht AS, Mittiga MR, Meinzen-Derr J, Geis GL, Kerrey BT Tags: Acad Emerg Med Source Type: research

The Prevalence and Diagnostic Utility of Systemic Inflammatory Response Syndrome Vital Signs in a Pediatric Emergency Department.
CONCLUSIONS: Systemic inflammatory response syndrome vital signs are common among medical pediatric patients presenting to an ED, and critical illness is rare. The majority of patients with SIRS vital signs were discharged without IV therapy and without readmission. Patients with SIRS vital signs had a statistically significant increased risk of critical care requirement, ED IV treatment, ED laboratory tests, admission, and readmission. However, SIRS vital sign criteria did not identify the majority of patients with mortality or need for critical care. SIRS vital signs had low sensitivity for critical illness, making it po...
Source: Accident and Emergency Nursing - March 16, 2015 Category: Emergency Medicine Authors: Scott HF, Deakyne SJ, Woods JM, Bajaj L Tags: Acad Emerg Med Source Type: research

Intrapatient diversity of Achromobacter spp. involved in chronic colonization of Cystic Fibrosis airways.
Abstract Achromobacter spp. are increasingly identified in Cystic Fibrosis (CF) patients and their ability to persistently colonize the CF respiratory tract (CFRT) suggests that Achromobacter species possess adaptive characteristics. We studied genome dynamics in 118 isolates recovered from 13 patients with Achromobacter chronic colonization (5-26 isolates per patient recovered over 13-61 months). Isolates were identified to species level by nrdA gene sequencing, subjected to Pulsed-Field Gel Electrophoresis (PFGE) and multiplex rep-PCR (MR-PCR), and rrs intragenomic diversity was studied by PCR-Temporal Temperatur...
Source: Infection, Genetics and Evolution - March 16, 2015 Category: Genetics & Stem Cells Authors: Dupont C, Michon AL, Jumas-Bilak E, Nørskov-Lauritsen N, Chiron R, Marchandin H Tags: Infect Genet Evol Source Type: research

Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain.
Abstract Recent epidemiological literatures imply that NO2 is a potential risk factor of neurological disorders. Whereas, the pathogenesis of various neurological diseases has been confirmed correlate to mitochondrial dysfunction, and mitochondria play the crucial roles in energy metabolism, free radicals production and apoptosis triggering in response to neuronal injury. Therefore, to clarify the possible mechanisms for NO2-induced neurotoxicity, in the present study, we investigated the possible effects of acute NO2 inhalation (5, 10 and 20mg/m(3) with 5h/day for 7 days) on energy metabolism and biogenesis in rat...
Source: Environmental Research - March 16, 2015 Category: Environmental Health Authors: Yan W, Ji X, Shi J, Li G, Sang N Tags: Environ Res Source Type: research

Comparison of P1 and 16S rRNA genes for detection of Mycoplasma pneumoniae by nested PCR in adults in Zhejiang, China
Conclusion: Our results indicate that the 16S rRNA gene is more suitable for diagnosis of M. pneumoniae infection than the P1 adhesin gene due to its higher sensitivity and positive rate in clinical samples. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - March 15, 2015 Category: Infectious Diseases Source Type: research

A case of human infection with avian Influenza A/H7N9 virus in Beijing: virological and serological analysis
This study described some essential viral and sera-characteristics of A/H7N9 virus infection in a 61-year old case patient. With the antiviral therapy and respiratory support, the patient showed a significant decrease of viral loads from 6.72 log10 copies/mL to 0 in 22 days, and a correlated increase of serum hemagglutination inhibition titers during the same period. Phylogenetic analysis demonstrated that the isolated strain was highly homologous to previous strains isolated in the southeast of China. Drug resistance-associated R292K mutation became detectable 17 days after antiviral therapy, but no remarkable influence o...
Source: The Journal of Infection in Developing Countries - March 15, 2015 Category: Infectious Diseases Source Type: research

Multimodality Imaging of Pericardial Disease
Abstract The emergence of multimodality imaging of pericardial diseases has improved diagnosis and management. In acute pericarditis, echocardiography is the first-line test, but cardiac magnetic resonance (CMR) may be beneficial in patients who fail to respond to therapy. An increased T2 short-tau inversion recovery time (STIR) suggests pericardial edema, and increased late gadolinium enhancement (LGE) suggests organizing pericarditis. Computed tomography (CT) can be helpful in procedural planning, either to guide percutaneous drainage of an effusion or to assess calcification and the location of vascular struct...
Source: Current Cardiology Reports - March 15, 2015 Category: Cardiology Source Type: research

Tonsillectomy, Adenoidectomy and Adenotonsillectomy Rates in School-aged Children: Relative Contributions of Socio-demographic and Clinical Features
The present study sought to investigate the frequencies of tonsillectomy, adenoidectomy and both adenotonsillectomy (T&A) among 6-12 year old children. In addition, we tried to find out the predictors associated with these previous upper respiratory tract (URT) surgeries. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - March 15, 2015 Category: ENT & OMF Authors: Yusuf C. Doganer, James E. Rohrer, Umit Aydogan, McKennan J. Thurston, Kenan Saglam Source Type: research

Sustained Aeration of Infant Lungs (SAIL) trial: study protocol for a randomized controlled trial
Background: Extremely preterm infants require assistance recruiting the lung to establish a functional residual capacity after birth. Sustained inflation (SI) combined with positive end expiratory pressure (PEEP) may be a superior method of aerating the lung compared with intermittent positive pressure ventilation (IPPV) with PEEP in extremely preterm infants. The Sustained Aeration of Infant Lungs (SAIL) trial was designed to study this question.Methods/DesignThis multisite prospective randomized controlled unblinded trial will recruit 600 infants of 23 to 26 weeks gestational age who require respiratory support at birth...
Source: Trials - March 15, 2015 Category: Journals (General) Authors: Elizabeth FogliaLouise OwenMarta ThioSarah RatcliffeGianluca ListaArjan te PasHelmut HummlerVinay NadkarniAnne AdesMichael PosenchegMartin KeszlerPeter DavisHaresh Kirpalani Source Type: research

Silencing of MUC8 by siRNA increases P2Y2-induced airway inflammation
Mucin hypersecretion and overproduction are frequent manifestations of respiratory disease. Determining the physiological function of airway mucin is presently considered more important than identifying the relevant signaling pathways. The lack of a full-length human mucin 8 (MUC8) cDNA sequence has hindered the generation of a Muc8 knockout mouse line. Thus, the precise physiological functions of MUC8 are unclear. Herein, we investigated the function of MUC8 using a small-interfering RNA (siRNA)-mediated genetic silencing approach in human airway epithelial cells. Herein, intracellular IL-1α production was stimulate...
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2015 Category: Respiratory Medicine Authors: Cha, H.-J., Jung, M.-S., Ahn, D. W., Choi, J.-K., Ock, M. S., Kim, K. S., Yoon, J.-H., Song, E. J., Song, K. S. Tags: CALL FOR PAPERS Source Type: research

Arginase inhibition prevents bleomycin-induced pulmonary hypertension, vascular remodeling, and collagen deposition in neonatal rat lungs
We report that arginase expression is increased in the lungs of bleomycin-exposed neonatal rats and that treatment with the arginase inhibitor amino-2-borono-6-hexanoic acid prevented the bleomycin-induced development of pulmonary hypertension and deposition of collagen. Arginase inhibition resulted in increased l-arginine and l-arginine bioavailability and increased pulmonary nitric oxide production. Arginase inhibition also normalized the expression of inducible nitric oxide synthase, and reduced bleomycin-induced nitrative stress while having no effect on bleomycin-induced inflammation. Our data suggest that arginase is...
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2015 Category: Respiratory Medicine Authors: Grasemann, H., Dhaliwal, R., Ivanovska, J., Kantores, C., McNamara, P. J., Scott, J. A., Belik, J., Jankov, R. P. Tags: CALL FOR PAPERS Source Type: research

Matrix metalloproteinase (MMP)-19-deficient fibroblasts display a profibrotic phenotype
In this study, we explored the effect of MMP-19 deficiency on fibroblast gene expression and cell behavior. Microarray analysis of Mmp19–/– lung fibroblasts revealed the dysregulation of several profibrotic pathways, including ECM formation, migration, proliferation, and autophagy. Functional studies confirmed these findings. Compared with wild-type mice, Mmp19–/– lung fibroblasts showed increased α1 (I) collagen gene and collagen protein production at baseline and after transforming growth factor-β treatment and increased smooth muscle-α actin expression (P < 0.05). Likewise, Mm...
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2015 Category: Respiratory Medicine Authors: Jara, P., Calyeca, J., Romero, Y., Placido, L., Yu, G., Kaminski, N., Maldonado, V., Cisneros, J., Selman, M., Pardo, A. Tags: ARTICLES Source Type: research

Macitentan reverses early obstructive pulmonary vasculopathy in rats: early intervention in overcoming the survivin-mediated resistance to apoptosis
In conclusion, macitentan reversed early but not late obstructive PVD in rats. This reversal was associated with the suppression of survivin-related resistance to apoptosis and proliferation of cells in PVD. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2015 Category: Respiratory Medicine Authors: Shinohara, T., Sawada, H., Otsuki, S., Yodoya, N., Kato, T., Ohashi, H., Zhang, E., Saitoh, S., Shimpo, H., Maruyama, K., Komada, Y., Mitani, Y. Tags: ARTICLES Source Type: research

Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production
Streptococcus pneumoniae is the most common cause of severe pneumonia in the elderly. However, the impact of aging on the innate inflammatory response to pneumococci is poorly defined. We compared the innate immune response in old vs. young adult mice following infection with S. pneumoniae. The accumulation of neutrophils recovered from bronchoalveolar lavage fluid and lung homogenates was increased in aged compared with young adult mice, although bacterial outgrowth was similar in both age groups, as were markers of microvascular leak. Aged mice had similar levels of IL-1β, TNF, IFN-, IL-17, and granulocyte colony-st...
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2015 Category: Respiratory Medicine Authors: Williams, A. E., Jose, R. J., Brown, J. S., Chambers, R. C. Tags: ARTICLES Source Type: research