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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 14.

Surveillance for respiratory health care–associated infections among inpatients in 3 Kenyan hospitals, 2010-2012
Conclusion We identified rHAIs in all ward types under surveillance in Kenyan hospitals. Viruses may have a substantial role in these infections, particularly among pediatric populations. Further research is needed to refine case definitions and understand rHAIs in ICUs. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - October 12, 2014 Category: Infectious Diseases Source Type: research

Twitter mining for fine-grained syndromic surveillance
Conclusions Our approach yields a very high level of correlation with flu trends derived from traditional surveillance systems. Compared with Google Flu, another popular tool based on query search volumes, our method is more flexible and less sensitive to changes in web search behaviors. (Source: Artificial Intelligence in Medicine)
Source: Artificial Intelligence in Medicine - October 12, 2014 Category: Bioinformatics Source Type: research

0209: Monoamine oxidases as novel sources of reactive oxygen species in experimental diabetes
In conclusion, MAO-derived ROS contribute to endothelial dysfunction in the diabetic rat. Further experiments are required to assess the mechanisms underlying MAO-dependent H2O2 formation. This work was supported by the university grant for young researchers, project code PII-C2-TC-2014 (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - October 12, 2014 Category: Cardiology Source Type: research

Internal contamination with leech in a turkey
Publication date: February 2015 Source:Asian Pacific Journal of Tropical Disease, Volume 5, Issue 2 Author(s): Mahmoud Bahmani , Majid Gholami-Ahangaran , Fereidoun Ghotbian , Hassan Hassanzadazar , Seyed Ahmad Karamati , Reza Sepahvand , Ayoub Darabi Leech enters to mouth and nose through water. Nose and nasopharynx mucosa are the most preferred places for leech attachment with epistaxis and respiratory distress symptoms. But the leeches may rarely stick deeper to trachea or esophagus which could cause hematemesis, hemoptysis and severe respiratory distress. Leech infestation can cause gastrointestinal, respiratory and ...
Source: Asian Pacific Journal of Tropical Disease - October 12, 2014 Category: Tropical Medicine Source Type: research

Evaluation of antimicrobial study in in vitro application of Clerodendrum infortunatum Linn.
Conclusions The findings evidently appear promising antibacterial and antifungal properties of Clerodendrum infortunatum against antagonistic pathogens. Leaf possesses quite potent activity than root and stem specially leaf extract>root extract>stem extract. This study serves as basis for further research to lead compounds to be isolated so that it may be as a template for the implications of these results for bioactivity and drug discovery potential of herbal products. (Source: Asian Pacific Journal of Tropical Disease)
Source: Asian Pacific Journal of Tropical Disease - October 12, 2014 Category: Tropical Medicine Source Type: research

Molecular detection of the carriers of Staphylococcus aureus golden in referred to the Imam Ali Clinic in Shahrekord, Iran
Conclusions The results of the present study showed that the frequency of the S. aureus strain isolated from the nasal swabs of patients with respiratory tract infections admitted to the Imam Ali Clinic in Shahrekord, Iran, was remarkable. Thus, knowing detection of S. aureus carriers, who are at a risk of spreading nosocomial infection among the staff, is vital to control and prevent nosocomial infections. (Source: Asian Pacific Journal of Tropical Disease)
Source: Asian Pacific Journal of Tropical Disease - October 12, 2014 Category: Tropical Medicine Source Type: research

Delivery systems for siRNA drug development in cancer therapy
Publication date: Available online 28 August 2014 Source:Asian Journal of Pharmaceutical Sciences Author(s): Cong-fei Xu , Jun Wang Since the discovery of the Nobel prize-winning mechanism of RNA interference (RNAi) ten years ago, it has become a promising drug target for the treatment of multiple diseases, including cancer. There have already been some successful applications of siRNA drugs in the treatment of age-related macular degeneration and respiratory syncytial virus infection. However, significant barriers still exist on the road to clinical applications of siRNA drugs, including poor cellular uptake, instabilit...
Source: Asian Journal of Pharmaceutical Sciences - October 12, 2014 Category: Drugs & Pharmacology Source Type: research

Chronic obstructive pulmonary disease: Emergency care in acute exacerbation
Publication date: Available online 20 August 2014 Source:African Journal of Emergency Medicine Author(s): Tedd J. Welniak , Amy Panzenbeck , Alex Koyfman , Mark Foran Chronic obstructive pulmonary disease (COPD) is a preventable condition affecting more than 230 million people globally, and is expected to become the world’s third largest cause of mortality by 2030. Despite this fact, it is thought to be widely underdiagnosed and underreported across the African continent. This presents a challenge to emergency medicine (EM) providers in the region, who are faced with treating large numbers of patients presenting with e...
Source: African Journal of Emergency Medicine - October 12, 2014 Category: Emergency Medicine Source Type: research

Assessment of knowledge and skills of triage amongst nurses working in the emergency centres in Dar es Salaam, Tanzania
Discussion Nurses who participated in this study demonstrated significant deficits in knowledge and skills regarding patients’ triaging in the EC. To correct these deficits, immediate in-service training/education workshops should be carried out, followed by continuous professional development on a regular basis, including refresher training, supportive supervision and clinical skills sessions. (Source: African Journal of Emergency Medicine)
Source: African Journal of Emergency Medicine - October 12, 2014 Category: Emergency Medicine Source Type: research

Isolated dysphagia unmasking bulbar neurosarcoidosis and pulmonary sarcoidosis
We report a 54year old female presenting with a six month history of worsening dysphagia. She denied respiratory symptoms. Physical exam was normal. ESR was 61mm/hr. Serum ACE level was 65mcg/L. Chest X-ray was normal. Esophagram revealed a large amount of contrast pooling in pharyngeal recesses with intermittent laryngeal aspiration. Swallow videofluorography showed a decreased retraction of the base of the tongue, limited laryngeal elevation, and a large amount of contrast pooling in pharyngeal recesses with intermittent laryngeal aspiration. EGD showed a normal opening of the upper esophageal sphincter and the cricophar...
Source: Arab Journal of Gastroenterology - October 12, 2014 Category: Gastroenterology Source Type: research

Legalizing Cannabis: A physician’s primer on the pulmonary effects of marijuana
Abstract Habitual smoking of marijuana is associated with multiple respiratory symptoms such as cough, sputum production, and wheezing .These symptoms are not significantly different from those exhibited by tobacco smokers. Furthermore, endobronchial biopsies of habitual smokers of marijuana and /or tobacco have shown that both marijuana and cigarette smoking cause significant bronchial mucosal histopathology and that these effects are additive. Although marijuana smokers have minimal changes in pulmonary function studies as compared to tobacco smokers, they may develop bullous disease and spontaneous pneumothorac...
Source: Current Respiratory Care Reports - October 11, 2014 Category: Respiratory Medicine Source Type: research

Virologic testing in bronchiolitis: does it change management decisions and predict outcomes?
Conclusion: Although RSV bronchiolitis has a more severe clinical course, virologic testing does not help in management decisions, and at an individual level, as a performance test, it seems insufficient to precisely predict outcomes. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Prediction of the risk of coronary arterial lesions in Kawasaki disease by serum 25-hydroxyvitamin D 3
Conclusion: Serum 25-(OH)D3 levels were elevated dur-ing the acute phase in KD children who had subsequent CALs. Serum 25-(OH)D3 levels in the acute phase of KD may be used to predict subsequent CALs. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Lung function of preterm infants before and after viral infections
Conclusion: These results suggest viral LRTIs, regardless of whether hospitalisation is required, adversely affect prematurely born infants’ airway resistance at follow up. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Sudden unexpected death in epilepsy: addressing the challenges.
Abstract Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death. Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dysfunction are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the importance of providing information about SU...
Source: Epilepsy Curr - October 11, 2014 Category: Neurology Authors: Smithson WH, Colwell B, Hanna J Tags: Curr Neurol Neurosci Rep Source Type: research

Human parvovirus B19: A review.
Abstract UNLABELLED: Parvovirus B19 (B19V) is a small non-enveloped single-stranded DNA (ssDNA) virus of the family Parvoviridae, the subfamily Parvovirinae, the genus Erythrovirus and Human parvovirus B19 type species. It is a common community-acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus. B19V infection is associated with a wide spectrum of clinical manifestations, some of which were well established and ...
Source: Acta Virologica - October 11, 2014 Category: Infectious Diseases Authors: Rogo LD, Mokhtari-Azad T, Kabir MH, Rezaei F Tags: Acta Virol Source Type: research

An intriguing finding in the right atrium
A 67-year-old male presented with shortness of breath, exacerbated by standing up and walking around and alleviated upon lying down. There was no associated coughing or chest pain. His medical history was notable for chronic alcohol abuse, chronic obstructive pulmonary disease and two recent admissions for aspiration pneumonitis. An inferior vena cava (IVC) filter had been placed 10 years earlier due to a pulmonary embolism. He denied illicit drug use. He was not taking any regular medications. On physical examination: T 97.6, P 100, BP 101/70, RR 30, O2 sat 95% supine and 91% upright on room air. He looked dishevelle...
Source: Heart - October 11, 2014 Category: Cardiology Authors: Schwartzenberg, S., Passeri, J. J. Tags: Image challenges, Venous thromboembolism, Clinical diagnostic tests Source Type: research

[Case Report] Dyspnoea, weight loss, fever, and headache caused by extrapulmonary tuberculosis in a prison inmate
A 55-year-old Panamanian man was referred from a penitentiary clinic to Hospital Santo Tomás in March, 2014. He presented with a 10-day history of breathing difficulty, chest pain, fever, headache, and had also lost more than 10 kg in weight over the previous 2 months. His medical and family history was unremarkable; however, he reported that he had been in contact with inmates who had had chronic cough for 2 years. The patient's vital signs were normal, apart from a respiratory rate of 28 breaths per min. (Source: LANCET)
Source: LANCET - October 11, 2014 Category: Journals (General) Authors: Musharaf Tarajia, Fabio Jaramillo, Amaranta Pernett, Nelson Santamaría, Amador Goodridge Tags: Case Report Source Type: research

Cold Spells and the Risk of Hospitalization for Asthma: New York, USA 1991–2006
Conclusions The results suggest that during prolonged periods of severe cold asthmatics may adhere to medical guidelines and limit their exposure, thereby preventing exacerbations. They may be less likely to alter their behavior in the more moderate months of November and April. (Source: Lung)
Source: Lung - October 11, 2014 Category: Respiratory Medicine Source Type: research

Nationwide patient registry for GNE myopathy in Japan
Conclusion: The Japanese Remudy-GNE myopathy is useful for clarifying the natural history of the disease and recruiting patients with genetically-confirmed GNE myopathy for clinical trials. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - October 11, 2014 Category: Internal Medicine Authors: Madoka Mori-YoshimuraYukiko HayashiNaohiro YonemotoHarumasa NakamuraMiho MurataShin¿ichi TakedaIchizo NishinoEn Kimura Source Type: research

Characterization of the chaperonin GroEL in Mycoplasma gallisepticum.
This study is the first report of the biological characterization of chaperone GroEL protein in MG. PMID: 25304689 [PubMed - as supplied by publisher] (Source: Archives of Microbiology)
Source: Archives of Microbiology - October 11, 2014 Category: Microbiology Authors: Tan L, Hu M, Yu S, Wang X, Lu F, Liu F, Qiu X, Song C, Sun Y, Ding C Tags: Arch Microbiol Source Type: research

Beyond the whole genome consensus: Unravelling of PRRSV phylogenomics using next generation sequencing technologies.
Abstract The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into the European and North American-like genotype 1 and 2 respectively. In addition to this intra-strains variability, the impact of coexisting viral quasispecies on disease development has recently gained much attention; owing very much to the advent of the next-generation sequencing (NGS) technolo...
Source: Virus Research - October 11, 2014 Category: Virology Authors: Lu ZH, Archibald AL, Ait-Ali T Tags: Virus Res Source Type: research

Monte Carlo simulations of clinically-realistic respiratory gated 18F-FDG PET: Application to lesion detectability and volume measurements
PET using 18F-FluoroDeoxyGlucose (18F-FDG PET) is a useful adjunct to Computed Tomography (CT) for radiotherapy planning. It yields a better delineation and discrimination of tumor tissues especially in patients with Non-Small Cell Lung Cancer (NSCLC). When combined with CT planning images, it often leads radiation oncologists to modify the definition of the Gross Tumor Volume (GTV) [1]. Using 18F-FDG PET also decreases inter and intra observer variability in tumor delineation [2]. However, in PET/CT thoracic imaging, respiratory motion has been reported as a limiting factor reducing image quality and biasing lesion volume...
Source: Computer Methods and Programs in Biomedicine - October 11, 2014 Category: Bioinformatics Authors: S. Vauclin, C. Michel, I. Buvat, K. Doyeux, A. Edet-Sanson, P. Vera, I. Gardin, S. Hapdey Source Type: research

Cost-effectiveness of CPAP treatment related to cardiovascular disease in patients with severe OSAS: the Greek experience
(Source: Sleep and Breathing)
Source: Sleep and Breathing - October 10, 2014 Category: Respiratory Medicine Source Type: research

RSV and its propensity for causing bronchiolitis
Abstract Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, i.e., bronchiolitis. The most common eitological agents causing bronchiolitis in young children are the respiratory viruses and of the commonly encountered respiratory viruses, Respiratory Syncytial Virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of ...
Source: The Journal of Pathology - October 10, 2014 Category: Pathology Authors: Raymond J Pickles, John DeVincenzo Tags: Invited Review Source Type: research

Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion
ConclusionsThe current study suggests that PNA clamping had a good concordance with direct sequencing for the detection of KRAS mutation in patients with malignant effusion. Furthermore, the good diagnostic performance obtained from pleural effusion samples provides evidence that pleural effusion can be a useful source for detecting KRAS mutation in a clinical setting, in which the collection of tumour tissues is challenging. (Source: Respirology)
Source: Respirology - October 10, 2014 Category: Respiratory Medicine Authors: Ji Young Kang, Chan Kwon Park, Chang Dong Yeo, Hea Yeon Lee, Chin Kook Rhee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Mi Sun Park, Hyeon Woo Yim Tags: Original Article Source Type: research

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
Conclusions: We show for the first time that COPD susceptibility at young age associates with an increased systemic innate immune response to cigarette smoking. This suggests a role of systemic inflammation in the early induction phase of COPD.Trial NCT00807469 (Source: Respiratory Research)
Source: Respiratory Research - October 10, 2014 Category: Respiratory Medicine Authors: Susan HoonhorstWim TimensLeo KoendermanAdèle Lo Tam LoiJan-Willem LammersH BoezenAntoon van OosterhoutDirkje PostmaNick ten Hacken Source Type: research

Comparing early years and childhood experiences and outcomes in Scotland, England and three city-regions: a plausible explanation for Scottish 'excess' mortality?
Conclusion: Based on these samples, the study does not support the hypothesis that EYCE were worse in Scotland and Glasgow and the Clyde Valley. It seems, therefore (based on these data), less likely that the roots of the excess mortality observed in the Scottish areas can be explained by these factors. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - October 10, 2014 Category: Epidemiology Authors: Martin TaulbutDavid WalshJohn O¿Dowd Source Type: research

Public reporting improves antibiotic prescribing for upper respiratory tract infections in primary care: a matched-pair cluster-randomized trial in China
Conclusions: The results suggest that PR could improve prescribing practices in terms of reducing oral antibiotics and combined use of antibiotics; however, the impacts were limited. We suggest that PR would probably be enhanced by provider payment reform, management and training for providers, and health education for patients. (Source: Health Research Policy and Systems)
Source: Health Research Policy and Systems - October 10, 2014 Category: Global & Universal Authors: Lianping YangChaojie LiuLijun WangXi YinXinping Zhang Source Type: research

Retrospective observational study of patients who present to Australian rural emergency departments with undifferentiated chest pain
ConclusionsThis study has provided information on the characteristics and processes of care for patients presenting to Australian rural EDs with undifferentiated chest pain that will inform service planning and further research to evaluate the effectiveness of care for these patients. (Source: Australian Journal of Rural Health)
Source: Australian Journal of Rural Health - October 10, 2014 Category: Rural Health Authors: Tina Roche, Glenn Gardner, Peter Lewis Tags: Original Research Source Type: research

Omega‐3 Fatty Acid Supplementation Provides an Additional Benefit to a Low‐Dust Diet in the Management of Horses with Chronic Lower Airway Inflammatory Disease
Conclusions and Clinical ImportanceFeeding horses with RAO and IAD a PUFA supplement containing 1.5–3 g DHA for 2 months provides an additional benefit to low‐dust diet. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: N. Nogradi, L.L. Couetil, J. Messick, M.A. Stochelski, J.R. Burgess Tags: Standard Article Source Type: research

Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay
Conclusions and Clinical ImportancePlasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: P.R. Fox, M.A. Oyama, M.J. Hezzell, J.E. Rush, T.P. Nguyenba, T.C. DeFrancesco, L.B. Lehmkuhl, H.B. Kellihan, B. Bulmer, S.G. Gordon, S.M. Cunningham, J. MacGregor, R.L. Stepien, B. Lefbom, D. Adin, K. Lamb Tags: Standard Article Source Type: research

α-Hemolysin Activity of Methicillin-Susceptible S. aureus Predicts Ventilator-Associated Pneumonia.
Conclusions. MSSA strains with strong blood-agar hemolysis and high alpha-hemolysin activity are markers for VAP, but not VAT and, might be considered in differential diagnosis and initiation of therapy. PMID: 25303310 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Stulik L, Malafa S, Hudcova J, Rouha H, Henics BZ, Craven DE, Sonnevend AM, Nagy E Tags: Am J Respir Crit Care Med Source Type: research

Risk Assessment of Tuberculosis in Immunocompromised Patients - A TBNET Study.
Conclusions: Among immunocompromised patients evaluated in this study, progression towards tuberculosis was highest in HIV-infected individuals and was poorly predicted by TST or IGRAs Clinical trial registration information available at, ID NCT00707317. PMID: 25303140 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Gorek Dilektasli A, Domínguez J, Duarte R, Ernst M, Oner Eyuboglu F, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ra Tags: Am J Respir Crit Care Med Source Type: research

PDGF Signaling in the Lung - From Lung Development and Disease to Clinical Studies.
In conclusion, while PDGF inhibition is currently used in multiple clinical trials, we suggest that more elaborate and specific approaches for spatio-temporal control of PDGF signaling are required for developing personalized approaches involving PDGF signaling in lung disease. PMID: 25303647 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Noskovičová N, Petřek M, Eickelberg O, Heinzelmann K Tags: Am J Respir Cell Mol Biol Source Type: research

Thrombin Down-Regulates Tissue Factor Pathway Inhibitor Expression in a PI3K/NFκB-Dependent Manner in Human Pleural Mesothelial Cells.
Abstract Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity either by regulating its expression or modifying the protein. It is not clear how TFPI activity is regulated in normal physiology or in injury. Because thrombin and TFPI are both locally elaborated in pleural injury, we sought to determine if thrombin could regulate TFPI in human pleural mesothelial cells (HPMCs). Thrombin significantly decreased TFPI mRNA and protein levels by ...
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Jeffers A, Owens S, Koenig K, Quaid B, Pendurthi UR, Rao LV, Idell S, Tucker TA Tags: Am J Respir Cell Mol Biol Source Type: research

Acute flaccid paralysis with anterior myelitis - california, june 2012-june 2014.
Abstract In August 2012, the California Department of Public Health (CDPH) was contacted by a San Francisco Bay area clinician who requested poliovirus testing for an unvaccinated man aged 29 years with acute flaccid paralysis (AFP) associated with anterior myelitis (i.e., evidence of inflammation of the spinal cord involving the grey matter including anterior horn cell bodies) and no history of international travel during the month before symptom onset. Within 2 weeks, CDPH had received reports of two additional cases of AFP with anterior myelitis of unknown etiology. Testing at CDPH's Viral and Rickettsial Diseas...
Source: MMWR Morb Mortal Wkl... - October 10, 2014 Category: Epidemiology Authors: Ayscue P, Haren KV, Sheriff H, Waubant E, Waldron P, Yagi S, Yen C, Clayton A, Padilla T, Pan C, Reichel J, Harriman K, Watt J, Sejvar J, Nix WA, Feikin D, Glaser C, Ek M Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Acute neurologic illness of unknown etiology in children - colorado, august-september 2014.
Abstract On September 12, 2014, CDC was notified by the Colorado Department of Public Health and Environment of a cluster of nine children evaluated at Children's Hospital Colorado with acute neurologic illness characterized by extremity weakness, cranial nerve dysfunction (e.g., diplopia, facial droop, dysphagia, or dysarthria), or both. Neurologic illness onsets occurred during August 8-September 15, 2014. The median age of the children was 8 years (range = 1-18 years). Other than neck, back, or extremity pain in some patients, all had normal sensation. All had a preceding febrile illness, most with upper respira...
Source: MMWR Morb Mortal Wkl... - October 10, 2014 Category: Epidemiology Authors: Pastula DM, Aliabadi N, Haynes AK, Messacar K, Schreiner T, Maloney J, Dominguez SR, Davizon ES, Leshem E, Fischer M, Nix WA, Oberste MS, Seward J, Feikin D, Miller L Tags: MMWR Morb Mortal Wkly Rep Source Type: research

The Role of Donor Chronic Alcohol Abuse in the Development of Primary Graft Dysfunction in Lung Transplant Recipients.
Abstract : Primary graft dysfunction (PGD) following lung transplantation is clinically similar to the acute respiratory distress syndrome. Because alcohol abuse independently increases the incidence of acute respiratory distress syndrome in at-risk individuals, we hypothesized that donor alcohol use is correlated with an increased risk of PGD. As a pilot study, we collected alcohol use histories using a validated instrument, the Alcohol Use Disorder Identification Test questionnaire, from 74 donors and correlated these with the development of PGD in corresponding recipients. Nineteen percent (14/74) of donors were...
Source: The American Journal of the Medical Sciences - October 10, 2014 Category: Journals (General) Authors: Pelaez A, Mitchell PO, Shah NS, Force SD, Elon L, Brown LA, Guidot DM Tags: Am J Med Sci Source Type: research

Inflammatory Patterns in Asthmatic Children Based on Alveolar Nitric Oxide Determination.
CONCLUSIONS: Normal values obtained are similar to those previously reported. Asthmatics with high CANO showed higher morbidity. No correlation was found between proximal and distal inflammation. PMID: 25311845 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 10, 2014 Category: Respiratory Medicine Authors: Corcuera-Elosegui P, Sardón-Prado O, Aldasoro-Ruiz A, Korta-Murua J, Mintegui-Aramburu J, Emparanza-Knorr JI, Pérez-Yarza EG Tags: Arch Bronconeumol Source Type: research

Late-onset Glycogen Storage Disease type 2.
Abstract Glycogenosis II (GSDII) is an autosomal recessive lysosomal storage disorder resulting from acid alpha-glucosidase (GAA) deficiency, subsequent lysosomal accumulation of glycogen in muscles, impairment of autophagic processes and progressive cardiac, motor and respiratory failure. The infantile form usually appears in the first month of life, progresses rapidly and presents with severe cardiac involvement and complete deficiency of alpha-glucosidase activity (< 1% of normal controls). The late-onset form is characterized by great variability of the phenotypical spectrum. Main findings are muscle weaknes...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Filosto M, Cotelli MS, Vielmi V, Todeschini A, Rinaldi F, Rota S, Scarpelli M, Padovani A Tags: Curr Mol Med Source Type: research

Mitochondrial Disorders in Adults.
Abstract Mitochondrial Disorders (MD) include a heterogeneous group of inherited disorders due to molecular defects mainly affecting the mitochondrial oxidative phosphorylation system. Because the respiratory chain is under control of two different genomes (nuclear DNA-nDNA and mitochondrial DNA-mtDNA), mitochondrial genetics is quite complex and may justify the extreme clinical heterogeneity of these diseases. Clinically, MD usually involve multiple tissues, mainly affecting organs with high energy request as central nervous system and skeletal muscle. They may present at any age, with different onsets, clinical p...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Toscano A, Musumeci O Tags: Curr Mol Med Source Type: research

Mitochondrial Diseases in Childhood.
Abstract Mitochondrial disorders are a group of heterogeneous diseases associated with abnormalities of the oxidative phosphorylation (OXPHOS), the most important source of energy for the cell. The number of mitochondrial syndromes and of identified causative genes is constantly increasing. Taken as a whole they are among the most frequent genetic diseases in humans at any age. The respiratory chain is the only metabolic pathway under double genome control and molecular genetics of these disorders is complicated by the existence of strict interactions between mitochondrial DNA and nuclear DNA. In childhood and infa...
Source: Current Molecular Medicine - October 10, 2014 Category: Molecular Biology Authors: Ardissone A, Lamantea E, Invernizzi F, Zeviani M, Genitrini S, Moroni I, Uziel G Tags: Curr Mol Med Source Type: research

Usefulness of phrenic latency and forced vital capacity in patients with ALS with latent respiratory dysfunction
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease that involves upper and lower motor neurons. Presently, there is no effective treatment for this disease. The main etiology of death in patients with ALS is respiratory failure caused by dysfunction of the diaphragm. Although symptoms of respiratory distress are uncommon in the early stage of ALS, except in bulbar-onset ALS (Evangelista et al., 1995), all patients eventually suffer from respiratory discomfort by progressive diaphragmatic weakness, which results in death or tracheostomy within 4 years from onset of disease (Ilzecka et al....
Source: Clinical Neurophysiology - October 10, 2014 Category: Neuroscience Authors: Soonwook Kwon, Ju-Hong Min, Hye-Jin Cho, Byung-Euk Joo, Eunbin Cho, Jin Myoung Seok, Min-Ji Kim, Byoung Joon Kim Source Type: research

Unintentional intramuscular administration of tPA/DNase for pleural infection
We report a patient treated in another center who was unintentionally administered up to six instillations of tPA (10 mg) and DNase (5 mg) intramuscularly via a malpositioned chest drain. The patient experienced minimal discomfort, and there were no signs of tissue inflammation or necrosis on computed tomography. No complications were detected over a 2‐month follow‐up. Upon transfer, a new pleural drain was inserted and tPA/DNase administered with clearance of his loculated complicated parapneumonic effusion. This case adds to the safety profile of intrapleural tPA/DNase therapy and highlights the importance of cor...
Source: Respirology Case Reports - October 10, 2014 Category: Respiratory Medicine Authors: Natalia Popowicz, Michael Nash, Y. C. Gary Lee Tags: Case Report Source Type: research

Therapeutic plasmapheresis in geriatric patients: Favorable results
Therapeutic plasma exchange, is generally a tolerable procedure, although several complications should be considered. Since geriatric population has been growing worldwide, the aim of this study was to retrospectively analyze 4709 TPE data from 981 geriatric procedures (20.8%) and to compare them with 3728 non-geriatric procedures (79.2%). The most common indications for TPE in both groups were sepsis/adult respiratory distress syndrome and multiple organ dysfunction. In geriatric patient group, contrary to expectations of aggravation, complication rate was statistically similar with non-geriatric group (P>0.05). (Source: ...
Source: Transfusion and Apheresis Science - October 10, 2014 Category: Hematology Authors: Pinar Ataca, Oya Adsiz Marasuna, Erol Ayyildiz, Meltem Bay, Osman Ilhan Source Type: research