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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Continuous Positive Airways Pressure and Uvulopalatopharyngoplasty Improves Pulmonary Hypertension in Patients with Obstructive Sleep Apnoea
Conclusions PH was frequent in OSA patients and normalized after 6 months with both CPAP and UPPP. A similar trend was noted in diastolic blood pressure. (Source: Lung)
Source: Lung - February 14, 2015 Category: Respiratory Medicine Source Type: research

Driver Gene Mutations of Non-Small-Cell Lung Cancer are Rare in Primary Carcinoids of the Lung: NGS Study by Ion Torrent
Abstract Lung carcinoids are rare neuroendocrine tumors of the lung. Very little is known about the genetic background of these tumors. We applied Ion Torrent Ampliseq next-generation technology to study hotspot mutations of 22 lung cancer-related genes from typical and atypical lung carcinoid tumors. DNA isolated from 25 formalin-fixed, paraffin-embedded carcinoid tumors were amplified to prepare barcoded libraries covering 507 mutations included in 90 amplicons. The libraries were pooled, purified, enriched, and sequenced on ion personal genome machine. The sequences were aligned and checked for known and novel ...
Source: Lung - February 14, 2015 Category: Respiratory Medicine Source Type: research

Carboxyhemoglobin and Methemoglobin in Asthma
Abstract Nitric oxide (NO) and carbon monoxide (CO) are synthesized at high levels in asthmatic airways. NO can oxidize hemoglobin (Hb) to methemoglobin (MetHb). CO binds to heme to produce carboxyhemoglobin (COHb). We hypothesized that MetHb and COHb may be increased in asthma. COHb, MetHb, and Hb were measured in venous blood of healthy controls (n = 32) and asthmatics (n = 31). Arterial COHb and oxyhemoglobin were measured by pulse CO-oximeter. Hb, oxyhemoglobin, and deoxyhemoglobin were similar among groups, but arterial COHb was higher in asthmatics than controls (p = 0.04). Venous COHb was similar amon...
Source: Lung - February 14, 2015 Category: Respiratory Medicine Source Type: research

Localization of annexins A1 and A2 in the respiratory tract of healthy calves and those experimentally infected with Mannheimia haemolytica
Abstract Annexins A1 and A2 are proteins known to function in the stress response, dampening inflammatory responses and mediating fibrinolysis. We found, in healthy cattle recently arrived to a feedlot, that lower levels of these proteins correlated with later development of pneumonia. Here we determine the localization of annexin A1 and A2 proteins in the respiratory tract and in leukocytes, in healthy calves and those with Mannheimia haemolytica pneumonia. In healthy calves, immunohistochemistry revealed cytoplasmic expression of annexin A1 in the surface epithelium of large airways, tracheobronchial glands and...
Source: Veterinary Research - February 14, 2015 Category: Veterinary Research Source Type: research

Identification of systemic immune response markers through metabolomic profiling of plasma from calves given an intra-nasally delivered respiratory vaccine
This study for the first time demonstrates the ability of untargeted UPLC-MS metabolomic profiling to identify metabolite immune correlates characteristic of immune responses following mucosal vaccination in calves. Male Holstein Friesian calves were vaccinated with Pfizer Rispoval® PI3 + RSV intranasal vaccine and metabolomic profiling of post-vaccination plasma revealed 12 metabolites whose peak intensities differed significantly from controls. Plasma levels of glycocholic acid, N-[(3α,5β,12α)-3,12-Dihydroxy-7,24-dioxocholan-24-yl]glycine, uric acid and biliverdin were found to be significantly elevated in vaccinated...
Source: Veterinary Research - February 14, 2015 Category: Veterinary Research Source Type: research

Small interfering RNA targeting nonstructural protein1 α (nsp1α) of porcine reproductive and respiratory syndrome virus (PRRSV) can reduce the replication of PRRSV in MARC-145 cells
In conclusion, this work indicated that nsp1α may be a viral pathogenicity factor of PRRSV and that siRNAs specifically targeting nsp1α may be a new strategy to control PRRSV in the future. (Source: Research in Veterinary Science)
Source: Research in Veterinary Science - February 14, 2015 Category: Veterinary Research Source Type: research

Outcome comparison between thoracic endovascular and open repair for type B aortic dissection: A population-based longitudinal study
Conclusion TEVAR for type B aortic dissection repair has less perioperative mortality, a shorter length of hospitalization, a higher midterm survival rate, less postoperative respiratory failure, and fewer wound complications than open surgery. (Source: Journal of the Chinese Medical Association)
Source: Journal of the Chinese Medical Association - February 14, 2015 Category: Journals (General) Source Type: research

Maternal bacteremia and the Irish maternity early warning system
Conclusion Among pregnant women with proven bacteremia, introduction of IMEWS has been associated with an improvement in the recording of vital signs, particularly respiratory rate. (Source: International Journal of Gynecology and Obstetrics)
Source: International Journal of Gynecology and Obstetrics - February 14, 2015 Category: OBGYN Source Type: research

Clinical Findings and Outcomes in Patients with Possible Usual Interstitial Pneumonia
Patients with possible usual interstitial pneumonia (UIP) constitute a substantial group, and their clinical characteristics and outcomes are not well defined. We compared the clinical characteristics and survival between patients with possible UIP and the UIP pattern. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - February 14, 2015 Category: Respiratory Medicine Authors: Jin Wook Lee, Esmeralda Shehu, Juarda Gjonbrataj, Young Eun Bahn, Byung Hak Rho, Mi-Young Lee, Won-Il Choi Source Type: research

Reversibility after inhaling salbutamol in different body postures in asthmatic children: a pilot study
Pulmonary medication is mostly delivered in the form of medical aerosols to minimize systemic side effects. A major drawback of inhaled medication is that the majority of inhaled particles impacts in the oropharynx at the sharp bend of the airway. Stretching the airway by a forward leaning body posture with the neck extended (“sniffing position”) may improve pulmonary deposition and clinical effects. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - February 14, 2015 Category: Respiratory Medicine Authors: R. Visser, J. van der Palen, F.H.C. de Jongh, B.J. Thio Source Type: research

A randomised, double-blind, four-way crossover trial comparing the 24-h FEV profile for once-daily versus twice-daily treatment with olodaterol, a novel long-acting β-agonist, in patients with chronic obstructive pulmonary disease
This randomised, double-blind, four-way, crossover, Phase II study compared the 24-h forced expiratory volume in 1 s (FEV1) profile of alternative dosing frequencies of two total daily doses of olodaterol (5 and 10 μg) in patients with chronic obstructive pulmonary disease (COPD). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - February 14, 2015 Category: Respiratory Medicine Authors: Guy F. Joos, Joseph-Leon Aumann, Carl Coeck, Lawrence Korducki, Alan L. Hamilton, Christina Kunz, René Aalbers Source Type: research

Factors associated with response to treatment of pulmonary exacerbations in cystic fibrosis patients
The objective of this study was to identify factors associated with lung function response to antibiotic treatment of pulmonary exacerbations. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 14, 2015 Category: Respiratory Medicine Authors: Valerie J. Waters, Sanja Stanojevic, Nicole Sonneveld, Michelle Klingel, Hartmut Grasemann, Yvonne C.W. Yau, Elizabeth Tullis, Pearce Wilcox, Andreas Freitag, Mark Chilvers, Felix A. Ratjen Tags: Original Article Source Type: research

Respiratory physiology & neurobiology
Publication date: March 2015 Source:Respiratory Physiology & Neurobiology, Volume 208 Author(s): Ekrem Şahan , Suzan Şahan , Murat Karamanlıoğlu (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - February 14, 2015 Category: Respiratory Medicine Source Type: research

Response to the Letter to the Editor
Publication date: March 2015 Source:Respiratory Physiology & Neurobiology, Volume 208 Author(s): Matthew N. Bartels , José González-Costello , Hilary F. Armstrong , Ulrich P. Jorde , Anna C. Bevelaqua , Laurie Letarte , Byron Thomashow (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - February 14, 2015 Category: Respiratory Medicine Source Type: research

Allosteric substrate inhibition of Arabidopsis NAD-dependent malic enzyme 1 is released by fumarate
Publication date: March 2015 Source:Phytochemistry, Volume 111 Author(s): Marcos Ariel Tronconi , Mariel Claudia Gerrard Wheeler , Andrea Martinatto , Juan Pablo Zubimendi , Carlos Santiago Andreo , María Fabiana Drincovich Plant mitochondria can use l-malate and fumarate, which accumulate in large levels, as respiratory substrates. In part, this property is due to the presence of NAD-dependent malic enzymes (NAD-ME) with particular biochemical characteristics. Arabidopsis NAD-ME1 exhibits a non-hyperbolic behavior for the substrate l-malate, and its activity is strongly stimulated by fumarate. Here, the possible struct...
Source: Phytochemistry - February 14, 2015 Category: Chemistry Source Type: research

Cardiorespiratory ontogeny and response to environmental hypoxia of larval spiny lobster, Sagmariasus verreauxi
Publication date: Available online 13 February 2015 Source:Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology Author(s): Quinn P. Fitzgibbon , Nicole Ruff , Stephen C. Battaglene Cardiorespiratory function is vital to an organism's ability to respond to environmental stress and analysis of cardiorespiratory capacity of species or life stages can elucidate vulnerability to climate change. Spiny lobsters have one of the most complex pelagic larval life cycles of any invertebrate and recently there has been an unexplained decline in post-larval recruitment for a number of species. We ...
Source: Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology - February 14, 2015 Category: Biochemistry Source Type: research

The Relationship between Seizure Onset Zone and Ictal Tachycardia: An Intracranial EEG Study
Autonomic discharges observed during seizures may lead to both cardiac and respiratory changes. Ictal sinus tachycardia is the most commonly observed electrocardiographic change and maximal ictal heart rate has been shown to be significantly higher in those who later died of sudden unexpected death in epilepsy (SUDEP)(Nei et al., 2004), a significant cause of death that may account for up to 17% of deaths among patients with epilepsy (Jehi and Najm 2008; Nei and Hays 2010). Prior studies have evaluated the influence of hemispheric laterality and/or lobar involvement at seizure onset on the degree and direction of these cha...
Source: Clinical Neurophysiology - February 14, 2015 Category: Neuroscience Authors: Maria Stefanidou, Chad Carlson, Daniel Friedman Source Type: research

A mathematical model approach quantifying patients’ response to changes in mechanical ventilation: Evaluation in volume support
Setting mechanical ventilation (MV) is difficult, with suboptimal settings increasing the risk of overloading the respiratory muscles, lung injury and organ system failure [1–3]. MV can be seen as a trade-off between conflicting goals [4], including the balance between: poor oxygenation and oxygen toxicity, ventilator induced lung injury and acidosis; and in support modes of ventilation, respiratory stress and effects of prolonged MV. Computer-based protocols have been developed to assist in setting the ventilator, encouraging reduction in support without overly stressing patients and keeping them within a comfort zone o...
Source: Medical Engineering and Physics - February 14, 2015 Category: Biomedical Engineering Authors: S. Larraza, N. Dey, D.S. Karbing, J.B. Jensen, M. Nygaard, R. Winding, S.E. Rees Source Type: research

A demonstration of the susceptibility of clinical isolates obtained from cystic fibrosis patients to manuka honey.
Abstract Pseudomonas and Burkholderia pose a significant health threat to people with chronic respiratory conditions; the resistance inherent in these bacteria indicates that new antimicrobial strategies are required. Susceptibility of 56 strains of P. aeruginosa and 55 strains of Burkholderia to manuka honey, tobramycin and colistin using microbroth dilution and E strip was determined. MICs of antibiotics with honey were determined to search for synergistic combinations against two representative strains of each genus. All strains exhibited susceptibility to honey ≤10 % (w/v); mean susceptibility of Burkholderi...
Source: Archives of Microbiology - February 14, 2015 Category: Microbiology Authors: Jenkins R, Wootton M, Howe R, Cooper R Tags: Arch Microbiol Source Type: research

Clinical significance of serum triglyceride elevation at early stage of acute biliary pancreatitis
This study aimed to study the clinical significances of triglyceride (TG) elevation in patients with ABP. Methods: We retrospectively analyzed a total of 426 ABP cases in our research center. According to the highest TG level within 72?h of disease onset, the patients were divided into a normal TG group and an elevated TG group. We analyzed the differences between the two groups of patients in aspects such as general information, disease severity, APACHE II (acute physiology and chronic health evaluation II) and Ranson scores, inflammatory cytokines, complications and prognosis. Results: Compared with the normal TG group, ...
Source: BMC Gastroenterology - February 14, 2015 Category: Gastroenterology Authors: Long ChengZhulin LuoKe XiangJiandong RenZhu HuangLijun TangFuzhou Tian Source Type: research

Inhibition of HMGCoA reductase by simvastatin protects mice from injurious mechanical ventilation
Conclusion: High-dose simvastatin prevents experimental hyperinflation lung injury by angioprotective and anti-inflammatory effects. (Source: Respiratory Research)
Source: Respiratory Research - February 14, 2015 Category: Respiratory Medicine Authors: Nikolaos ManitsopoulosStylianos OrfanosAnastasia KotanidouIoanna NikitopoulouIlias SiemposChristina MagkouIoanna DimopoulouSpyros ZakynthinosApostolos ArmaganidisNikolaos Maniatis Source Type: research

Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers
Background: Computed tomographic (CT) airway lumen narrowing is associated with lower lung function. Although volumetric CT measures of airways (wall volume [WV] and lumen volume [LV]) compared to cross sectional measures can more accurately reflect bronchial morphology, data of their use in never smokers is scarce. We hypothesize that native tracheobronchial tree morphology as assessed by volumetric CT metrics play a significant role in determining lung function in normal subjects. We aimed to assess the relationships between airway size, the projected branching generation number (BGN) to reach airways of (Source: Respiratory Research)
Source: Respiratory Research - February 14, 2015 Category: Respiratory Medicine Authors: Alejandro DiazFarbod RahaghiJames RossRola HarmoucheJuerg TschirrenRaul San José EstéparGeorge Washkofor the COPD Gene investigators Source Type: research

Copper sulphate reduces the metabolic activity of Gammarus fossarum in laboratory and field experiments.
Abstract The specialised fauna of freshwater springs is affected by contamination of the water with xenobiotics from human activities in the surrounding landscape. We assessed the effects of exposure to toxins in laboratory and field experiments by using copper sulphate as a model substance and Gammarus fossarum Koch, 1836, as the model organism. This amphipod is a common representative of the European spring fauna and copper is a widespread contaminant, mainly from agricultural practice. The experiments were conducted in test chambers placed in flow channels and directly in a spring. The gammarids were fed with co...
Source: Aquatic Toxicology - February 14, 2015 Category: Toxicology Authors: Schmidlin L, von Fumetti S, Nagel P Tags: Aquat Toxicol Source Type: research

Development and characterization of a panel of cross-reactive monoclonal antibodies generated using H1N1 influenza virus.
Abstract To characterize the antigenic epitopes of the hemagglutinin (HA) protein of H1N1 influenza virus, a panel consisting of 84 clones of murine monoclonal antibodies (mAbs) were generated using the HA proteins from the 2009 pandemic H1N1 vaccine lysate and the seasonal influenza H1N1(A1) vaccines. Thirty-three (39%) of the 84 mAbs were found to be strain-specific, and 6 (7%) of the 84 mAbs were subtype-specific. Twenty (24%) of the 84 mAbs recognized the common HA epitopes shared by 2009 pandemic H1N1, seasonal A1 (H1N1), and A3 (H3N2) influenza viruses. Twenty-five of the 84 clones recognized the common HA ep...
Source: Immunobiology - February 14, 2015 Category: Allergy & Immunology Authors: Guo CY, Tang YG, Qi ZL, Liu Y, Zhao XR, Huo XP, Li Y, Feng Q, Zhao PH, Wang X, Li Y, Wang HF, Hu J, Zhang XJ Tags: Immunobiology Source Type: research

Early Discharge After Pancreatoduodenectomy: What Helps and What Prevents?
Conclusions: Being overweight or obese and respiratory comorbidities are independent predictors of prolonged hospital stay despite the implementation of ERAS protocol. Hypoalbuminemia does not have a direct effect on hospital stay but may predispose the patient to the development of complications. (Source: Pancreas)
Source: Pancreas - February 13, 2015 Category: Gastroenterology Tags: Original Articles Source Type: research

Potential for Raman spectroscopy to provide cancer screening using a peripheral blood sample.
In conclusion this preliminary study has demonstrated the feasibility of using Raman spectroscopy in cancer screening and diagnostics of solid tumours through a peripheral blood sample. Further work needs to be carried out for this technique to be implemented in the clinical setting. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Bilateral para-tracheal lignocaine infiltration in open surgical tracheostomy.
Discussion and conclusion:Lignocaine infiltration in para-tracheal space just before tracheotomy lead to absent cough reflex with no exacerbation in respiratory distress. We strongly advocate use of lignocaine in para-tracheal space just before tracheotomy in open surgical tracheostomy. (Source: Head and Neck Oncology)
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Multidisciplinary approach of head and neck cancer in the elderly: an update.
Squamous-cell carcinoma of the head and neck (SCCHN) represents the sixth most common malignancy and accounts for approximately 6% of new cancer cases annually worldwide. Although the majority of cases occur between the fifth and sixth decades of life, their onset in patients older than 60 years is not rare and up to one fourth of SCCHN cases are diagnosed in patients older that 70 years. As the elderly population with SCCHN is constantly growing and as elderly cancer patients are severely under-represented in clinical trials, there is a clear need to address the particular aspects of this specific patient group, especiall...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

New perspectives to respiratory tract cancers.
Respiratory tract cancers (RTCs) which include the lung and head and neck squamous cell carcinoma are public health problem with incidence and mortality rates among the highest in the world. In order to reduce the health burden of RTCs, effective public health measures should be put in place.A strategy to achieve this goal could be explored using risk prediction modelling. DNA methylation and microRNAs have rapidly emerged as potential biomarkers for assessing the risk of early development and therapeutic stratification of various types of cancer. The integration of biomarkers in the development of risk prediction algorith...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Valproic acid suppresses growth and enhances cisplatin cytotoxicity to larynx cancer cells.
Larynx cancer is the most common head and neck neoplasia in developed nations. The treatment of advanced larynx cancer include chemotherapy, often using cisplatin. The limitations of many antineoplastic drugs are their low delivery into respiratory tissues, thus the need of higher doses which results in severe side effects, and the development of drug resistance by cancer cells. Therefore the need of drugs and drug combinations that potentiates each other, increasing safety by reducing doses and act on several pathways at the same time, acting more specifically on cancer cells. Histone deacetylase inhibitors are a promis...
Source: Head and Neck Oncology - February 13, 2015 Category: Cancer & Oncology Source Type: research

Anesthesia for stem cell transplantation in autistic children: A prospective, randomized, double-blind comparison of propofol and etomidate following sevoflurane inhalation.
In conclusion, sevoflurane-etomidate combinations resulted in more stable hemodynamic responses and relatively fewer adverse effects compared with propofol injection following sevoflurane inhalation and may therefore be more suitable for the induction of short-term anesthesia in autistic children during stem cell transplantation. PMID: 25667673 [PubMed - as supplied by publisher] (Source: Pain Physician)
Source: Pain Physician - February 13, 2015 Category: Anesthesiology Authors: Ma YH, Li YW, Ma L, Cao CH, Liu XD Tags: Exp Ther Med Source Type: research

Days out of role due to mental and physical illness in the South African stress and health study
Conclusions Comorbidity is common in both mental and physical disorders, and both are associated with substantial days out of role in South Africa. These data indicate substantial social and economic loss associated with these conditions, and emphasize the need to integrate health services to include common mental disorders in all basic packages of care and to assess for and manage comorbid conditions. (Source: Social Psychiatry and Psychiatric Epidemiology)
Source: Social Psychiatry and Psychiatric Epidemiology - February 13, 2015 Category: Psychiatry Source Type: research

Household‐Level Risk Factors for Influenza among Young Children in Dhaka, Bangladesh: A Case‐Control Study
ConclusionsHandwashing with soap was practiced infrequently, and was not associated with pediatric influenza in this community. Interventions aimed at crowded households may reduce influenza incidence in young children.This article is protected by copyright. All rights reserved. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - February 13, 2015 Category: Tropical Medicine Authors: Saumil Doshi, Benjamin J. Silk, Dhiman Dutt, Moshtaq Ahmed, Adam L. Cohen, Thomas H. Taylor, W. Abdullah Brooks, Doli Goswami, Stephen P. Luby, Alicia M. Fry, Pavani K. Ram Tags: Original Article Source Type: research

Sleep Position Trainer versus Tennis Ball Technique in Positional Obstructive Sleep Apnea Syndrome
Conclusion:In mild POSAS with normal EES the new SPT device and the standard TBT are equally effective in reducing respiratory indices. However, compared to the TBT, sleep quality, quality of life, and compliance improved significantly more in the SPT group.Citation:Eijsvogel MM, Ubbink R, Dekker J, Oppersma E, de Jongh FH, van der Palen J, Brusse-Keizer MG. Sleep position trainer versus tennis ball technique in positional obstructive sleep apnea syndrome. J Clin Sleep Med 2015;11(2):139–147. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - February 13, 2015 Category: Sleep Medicine Source Type: research

Reduced innervation in the human pharynx in patients with obstructive sleep apnea.
Authors: de Carlos F, Cobo J, Macías E, Feito J, González M, Cobo T, Fernández-Mondragón MP, García-Suárez O, Vega JA Abstract Obstructive sleep apnea is a disease characterized by repetitive breathing during sleep that lead to reduced oxygen saturation and sleep disturbance among other symptoms. Obstructive sleep apnea is caused by blockade of the upper respiratory airway, although the pathogenic mechanism underlying this occlusion remains unknown. In these studies we explored the hypothesis that alterations in the innervation, especially mechanosensory innervation, of the pharynx may contribute to obstructi...
Source: Histology and Histopathology - February 13, 2015 Category: Cytology Tags: Histol Histopathol Source Type: research

Guillain-Barre Syndrome After Robotically Assisted Laparoscopic Prostatectomy: First Case Report
We present the first case of GBS after Robotically Assisted Laparoscopic Prostatectomy using the daVinci® Surgical System. (Source: Urology Case Reports)
Source: Urology Case Reports - February 13, 2015 Category: Urology & Nephrology Source Type: research

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis
Conclusions: The value of PK/PD surrogate marker T%?>?MIC is of great utility in CEQ clinical usage. The very first CEQ PK/PD cutoff provide fundamental data for CEQ breakpoint determination. A more desirable dose regimen against H. parasuis was provided for CEQ using in China district. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 13, 2015 Category: Epidemiology Authors: Xia XiaoJian SunYi ChenRui-Juan HuangTing HuangGuilin QiaoYu-Feng ZhouYa-Hong Liu Source Type: research

Altered p53 and NOX1 activity cause bioenergetic defects in a SCA7 polyglutamine disease model
In this study we identified a previously unreported mechanism, involving disruption of p53 and NADPH oxidase 1 (NOX1) activity, by which the expanded SCA7 disease protein ATXN7 causes metabolic dysregulation. The NOX1 protein is known to promote glycolytic activity, whereas the transcription factor p53 inhibits this process and instead promotes mitochondrial respiration. In a stable inducible PC12 model of SCA7, p53 and mutant ATXN7 co-aggregated and the transcriptional activity of p53 was reduced, resulting in a 50% decrease of key p53 target proteins, like AIF and TIGAR. In contrast, the expression of NOX1 was increased ...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - February 13, 2015 Category: Biochemistry Source Type: research

Evolution of FOXRED1, an FAD-dependent oxidoreductase necessary for NADH:ubiquinone oxidoreductase (Complex I) assembly
Publication date: Available online 10 February 2015 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics Author(s): Bernard D. Lemire Complex I (NADH:ubiquinone oxidoreductase) is the major entry point for electrons into the respiratory chains of bacteria and mitochondria. Mammalian complex I is composed of 45 subunits and harbors FMN and iron–sulfur cluster cofactors. A heterogeneous disease profile is associated with complex I deficiency. In a large fraction of complex I deficiencies, the primary defect is not in any of the genes encoding a subunit. The proper assembly and function of complex I require the part...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - February 13, 2015 Category: Biochemistry Source Type: research

Human alveolar epithelial type II cells in primary culture
Abstract Alveolar epithelial type II (AEII) cells are a key structure and defender in the lung but also are the targets in many lung diseases, including acute respiratory distress syndrome, ventilator‐induced lung injury, and pulmonary fibrosis. We sought to establish an optimized method for high yielding and long maintenance of characteristics of primary human AEII cells to facilitate the investigation of the mechanisms of lung diseases at the cellular and molecular levels. Adult human peripheral normal lung tissues of oncologic patients undergoing lung resection were collected. The AEII cells were isolated and identifi...
Source: Physiological Reports - February 13, 2015 Category: Physiology Authors: Pu Mao, Songling Wu, Jianchun Li, Wei Fu, Weiqun He, Xiaoqing Liu, Arthur S. Slutsky, Haibo Zhang, Yimin Li Tags: Original Research Source Type: research

How well do vaccines for Bordetella bronchiseptica work in dogs? A critical review of the literature 1977-2014
Publication date: Available online 10 February 2015 Source:The Veterinary Journal Author(s): John A. Ellis Bordetella bronchiseptica (Bb) has long been causally associated with respiratory disease in dogs. Parenteral and intranasal vaccines for this pathogen have been in common use since their development in the late 1970s and early 1980s and recently a commercial oral Bb vaccine has become available. Overall, the literature (comprising experimental infection models and field studies) documents the efficacy of these vaccines in stimulating disease-sparing mucosal and systemic immune responses that can be associated with ...
Source: The Veterinary Journal - February 13, 2015 Category: Veterinary Research Source Type: research

Prior pneumococcal and influenza vaccinations and in‐hospital outcomes for community‐acquired pneumonia in elderly veterans
CONCLUSIONSignificant survival benefit and improved in‐hospital outcomes may not be expected among CAP‐hospitalized elderly patients with prior PV alone. However, having both PV and FV before CAP admission may reduce LOS. Journal of Hospital Medicine 2015. © 2015 Society of Hospital Medicine (Source: Journal of Hospital Medicine)
Source: Journal of Hospital Medicine - February 13, 2015 Category: Hospital Management Authors: Chenghui Li, Paul O. Gubbins, Guoqing J. Chen Tags: Original Research Source Type: research

Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies
Publication date: 10 February 2015 Source:Stem Cell Reports, Volume 4, Issue 2 Author(s): Nico Lachmann , Mania Ackermann , Eileen Frenzel , Steffi Liebhaber , Sebastian Brennig , Christine Happle , Dirk Hoffmann , Olga Klimenkova , Doreen Lüttge , Theresa Buchegger , Mark Philipp Kühnel , Axel Schambach , Sabina Janciauskiene , Constanca Figueiredo , Gesine Hansen , Julia Skokowa , Thomas Moritz Interleukin-3 (IL-3) is capable of supporting the proliferation of a broad range of hematopoietic cell types, whereas granulocyte colony-stimulating factor (G-CSF) and macrophage CSF (M-CSF) represent critical cytokines in my...
Source: Stem Cell Reports - February 13, 2015 Category: Stem Cells Source Type: research