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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Infection in Southern Chinese Patients with Systemic Lupus Erythematosus: Spectrum, Drug Resistance, Outcomes, and Risk Factors.
CONCLUSION: Infection was the leading cause of mortality in patients hospitalized with SLE. There were some notable features of infection in Chinese patients including early onset, higher proportion of respiratory tract involvement, predominance of GNB with emergence of MDR isolates, and a variety of pathogens. PMID: 27307524 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 15, 2016 Category: Rheumatology Authors: Chen D, Xie J, Chen H, Yang Y, Zhan Z, Liang L, Yang X Tags: J Rheumatol Source Type: research

Intensive care use and quality of care for patients with myocardial infarction and heart failure.
CONCLUSIONS: Hospitals with the highest rates of ICU admission for patients with AMI or HF delivered lower quality of care and had higher 30-day mortality for these conditions. High ICU use hospitals may be targets to improve care delivery. PMID: 27318172 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 15, 2016 Category: Respiratory Medicine Authors: Valley TS, Sjoding MW, Goldberger ZD, Cooke CR Tags: Chest Source Type: research

An assessment of the impacts of pesticide use on the environment and health of rice farmers in Sierra Leone.
Abstract One of the biggest challenges faced by Sierra Leonean farmers is pest control. Birds, rodents, insects, crustaceans and other organisms can drastically reduce yields. In order to prevent these organisms from destroying their crop, farmers use pesticides. However there are reports that these chemicals are being misused and such misuse is having a negative impact on the environment and the health of the farmers. This research study aimed to investigate the use of pesticides in rice fields and its potential effects on the environment and on the farmers of Sierra Leone. Five hundred farmers and one hundred hea...
Source: Environment International - June 15, 2016 Category: Environmental Health Authors: Sankoh AI, Whittle R, Semple KT, Jones KC, Sweetman AJ Tags: Environ Int Source Type: research

Preparation and heat resistance study of porcine reproductive and respiratory syndrome virus sugar glass vaccine.
Abstract To improve the preservation period without cold-chain of the live attenuated vaccine of porcine reproductive and respiratory syndrome (PRRS), a set of thermostable formulations composed of trehalose, tryptone and other protectants were dried by vacuum foam drying (VFD) along with PRRSV solutions. In the 37°C and 45°C resistance ageing test, the dried foam vaccine showed significant thermostability, and the virus titer lost 0.8 Log10 at 37°C for 4months, 1.0 Log10 at 45°C for 25days. Furthermore, the foam vaccine could be stored at 25°C for at least one year. Besides, the vaccine preserved in 37°C, 25...
Source: Vaccine - June 15, 2016 Category: Allergy & Immunology Authors: Lv F, Lu Y, Hao ZL, Zhao YH, Zhang LH, Feng L, Chen J, Wang LL, Rui R, Hou JB Tags: Vaccine Source Type: research

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus.
We report that the kinase RIPK3 is essential for IAV-induced lysis of mammalian fibroblasts and lung epithelial cells. Replicating IAV drives assembly of a RIPK3-containing complex that includes the kinase RIPK1, the pseudokinase MLKL, and the adaptor protein FADD, and forms independently of signaling by RNA-sensing innate immune receptors (RLRs, TLRs, PKR), or the cytokines type I interferons and TNF-α. Downstream of RIPK3, IAV activates parallel pathways of MLKL-driven necroptosis and FADD-mediated apoptosis, with the former reliant on RIPK3 kinase activity and neither on RIPK1 activity. Mice deficient in RIPK3 or doubl...
Source: Cell Host and Microbe - June 15, 2016 Category: Microbiology Authors: Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S Tags: Cell Host Microbe Source Type: research

Diagnosing viral and bacterial respiratory infections in acute COPD exacerbations by an electronic nose: a pilot study
Respiratory infections, viral or bacterial, are a common cause of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). A rapid, point-of-care, and easy-to-use tool distinguishing viral and bacterial from other causes would be valuable in routine clinical care. An electronic nose (e-nose) could fit this profile but has never been tested in this setting before. In a single-center registered trial (NTR 4601) patients admitted with AECOPD were tested with the Aeonose ® electronic nose, and a diagnosis of viral or bacterial infection was obtained by bacterial culture on sputa and viral PCR on nose swabs...
Source: Journal of Breath Research - June 15, 2016 Category: Respiratory Medicine Authors: Wouter H van Geffen, Marcel Bruins and Huib A M Kerstjens Source Type: research

Joint Annual Meeting of the Schweizerische Gesellschaft für Kardiologie / Société Suisse de Cardiologie. Schweizerische Gesellschaft für Herz- und thorakale Gefässchirurgie / Société Suisse de Chirurgie Cardiaque et Vasculaire Thoracique. Schweizerische Gesellschaft für Pneumologie / Société Suisse de Pneumologie. June 15-17, 2016, Lausanne: Abstracts
Respiration 2016;91:414-468 (Source: Respiration)
Source: Respiration - June 14, 2016 Category: Respiratory Medicine Source Type: research

Recurrent Chronic Obstructive Pulmonary Disease Exacerbations after Endobronchial Valve Implantation Are Associated with the Presence of Pseudomonas aeruginosa
Conclusions: Increased rates of COPD exacerbations after endobronchial valve implantation are associated with the presence of P. aeruginosa. The finding warrants further investigation.Respiration (Source: Respiration)
Source: Respiration - June 14, 2016 Category: Respiratory Medicine Source Type: research

Good practices for prone positioning at the bedside: Construction of a care protocol
The objective of this review is to revisit the current evidence in the literature, discuss and propose the construction of a protocol of care for these patients. A search was performed on the main electronic databases: Medline, Lilacs and Cochrane Library. Prone positioning is increasingly used in daily practice, with properly trained staff and a well established care protocol are essencial.RESUMO No último ano, o interesse pela posição prona no tratamento da síndrome da angústia respiratória aguda (Sara) ressurgiu com a demonstração da redução da mortalidade por um grande estudo clínico randomizado. Os relatos,...
Source: Revista da Associacao Medica Brasileira - June 14, 2016 Category: Journals (General) Source Type: research

The Effects of Statin Therapy on the Human Airway
Conclusion: Statins may have beneficial pleiotropic effects in addition to their actions as potent lipid-lowering agents particularly in patients with chronic obstructive pulmonary disease and post lung transplantation. Further human studies are required to substantiate their possible potential as many of the clinical trials performed to date have not demonstrated the translation of results of these promising scientific and observational studies into positive outcomes in well-designed, randomized, placebo-controlled human trials. (Source: Drug Metabolism Letters)
Source: Drug Metabolism Letters - June 14, 2016 Category: Drugs & Pharmacology Source Type: research

Acute lung injury induced by whole gastric fluid: hepatic acute phase response contributes to increase lung antiprotease protection
Gastric contents aspiration in humans is a risk factor for severe respiratory failure with elevated mortality. Although aspiration-induced local lung inflammation has been studied in animal models, little is k... (Source: Respiratory Research)
Source: Respiratory Research - June 14, 2016 Category: Respiratory Medicine Authors: Pedro Ayala, Manuel Meneses, Pablo Olmos, Rebeca Montalva, Karla Droguett, Mariana Ríos and Gisella Borzone Source Type: research

Interactions between respiratory oscillators in adult rats
Breathing in mammals is hypothesized to result from the interaction of two distinct oscillators: the preBötzinger Complex (preBötC) driving inspiration and the lateral parafacial region (pFL) driving active expiration. To understand the interactions between these oscillators, we independently altered their excitability in spontaneously breathing vagotomized urethane-anesthetized adult rats. Hyperpolarizing preBötC neurons decreased inspiratory activity and initiated active expiration, ultimately progressing to apnea, i.e., cessation of both inspiration and active expiration. Depolarizing pFL neurons produced active expi...
Source: eLife - June 14, 2016 Category: Biomedical Science Tags: neural microcircuits Neuroscience parafacial lateral region preB ötzinger Complex Rat respiration respiratory oscillators Source Type: research

Effects of indacaterol/glycopyrronium (QVA149) on lung hyperinflation and physical activity in patients with moderate to severe COPD: a randomised, placebo-controlled, crossover study (The MOVE Study)
Physical activity limitation is common in chronic obstructive pulmonary disease (COPD), and is associated with worse health status, and increased hospitalisation and mortality. Long-acting bronchodilators, eit... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - June 14, 2016 Category: Respiratory Medicine Authors: Henrik Watz, Claudia Mailänder, Monika Baier and Anne Kirsten Source Type: research

Development of the Pulmonary Arterial Hypertension-Symptoms and Impact (PAH-SYMPACT®) questionnaire: a new patient-reported outcome instrument for PAH
Regulators and clinical experts increasingly recognize the importance of incorporating patient-reported outcomes (PROs) in clinical studies of therapies for pulmonary arterial hypertension (PAH). No PAH-specif... (Source: Respiratory Research)
Source: Respiratory Research - June 14, 2016 Category: Respiratory Medicine Authors: Deborah McCollister, Shannon Shaffer, David B. Badesch, Arthur Filusch, Elke Hunsche, René Schüler, Ingela Wiklund and Andrew Peacock Source Type: research

Evaluating the impact of the multiplex respiratory virus panel polymerase chain reaction test on the clinical management of suspected respiratory viral infections in adult patients in a hospital setting
Publication date: Available online 13 June 2016 Source:American Journal of Infection Control Author(s): Colin Yee, Eva Suarthana, Nandini Dendukuri, Ioana Nicolau, Makeda Semret, Charles Frenette A retrospective cohort design was used to study the impact of a multiplex respiratory virus panel polymerase chain reaction test in 186 adult patients with suspected influenza-like illness. Decisions regarding continuation of empirical antiviral therapy appear to be impacted by the test. However, the impact on reducing antibiotic use remains unclear. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - June 14, 2016 Category: Infectious Diseases Source Type: research

Secukinumab: A Review in Psoriatic Arthritis
In conclusion, although longer-term and comparative data are lacking, current clinical data indicate that secukinumab is efficacious and well tolerated in the treatment of psoriatic arthritis, and it thus provides a useful treatment alternative to tumour necrosis factor inhibitors and other targeted DMARDs. (Source: Drugs)
Source: Drugs - June 14, 2016 Category: Drugs & Pharmacology Source Type: research

Increased expression of hCLCA1 in chronic rhinosinusitis and its contribution to produce MUC5AC
ConclusionsThe current findings indicate that the expression of hCLCA1 is increased in chronic rhinosinusitis and may be regulated by Th1 and Th2 cytokines, possibly contributing to the production of MUC5AC. Level of EvidenceNA Laryngoscope, 2016 (Source: The Laryngoscope)
Source: The Laryngoscope - June 14, 2016 Category: ENT & OMF Authors: Ha Kyun Kim, Jin Ho Kook, Ka Ram Kang, Dong Ju Oh, Tae Hoon Kim, Sang Hag Lee Tags: Allergy/Rhinology Source Type: research

Impact of Chronic Conditions and Multimorbidity on the Disability Burden in the Older Population in Belgium
Conclusions: The present findings provide a deeper understanding of the role of chronic conditions and multimorbidity on the disability burden in the older population in Belgium. Although the disease pairs showed a low contribution to the disability burden, their occurrence presented a high impact on disability. Prevention strategies to tackle disability should target the main contributors to the disability burden and the most disabling conditions/disease pairs, especially in the clinical practice. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - June 14, 2016 Category: Geriatrics Authors: Yokota, R. T. d. C., Van der Heyden, J., Nusselder, W. J., Robine, J.-M., Tafforeau, J., Deboosere, P., Van Oyen, H. Tags: Research Article Source Type: research

Role of mitochondrial dysfunction in cancer progression
Deregulated cellular energetics was one of the cancer hallmarks. Several underlying mechanisms of deregulated cellular energetics are associated with mitochondrial dysfunction caused by mitochondrial DNA mutations, mitochondrial enzyme defects, or altered oncogenes/tumor suppressors. In this review, we summarize the current understanding about the role of mitochondrial dysfunction in cancer progression. Point mutations and copy number changes are the two most common mitochondrial DNA alterations in cancers, and mitochondrial dysfunction induced by chemical depletion of mitochondrial DNA or impairment of mitochondrial respi...
Source: Experimental Biology and Medicine - June 14, 2016 Category: Research Authors: Hsu, C.-C., Tseng, L.-M., Lee, H.-C. Tags: Biochemistry & amp;amp; Molecular Biology Source Type: research

Highlights from this issue
Not throwing a sickie Respiratory symptoms are amongst the most common reasons for not attending work, but some occupations lend more to respiratory illness than others. Welding has been shown to increase the risk of pneumococcal illness and in the manuscript by Marongiu et al welders have a two-fold increase in respiratory symptoms and nearly a 50% increase in consultations for respiratory symptoms over the Winter suggesting that welders have increased susceptibility to infection compared with other manual workers (see page 601). Maybe welders need to "tumble outa bed, stumble into the kitchen, pour a cup of ambition" and...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Hart, N., Jenkins, G., Smyth, A. Tags: Airwaves Source Type: research

First year of the thoracic triumvirate
When we accepted the prestigious role of Joint Editors-in-Chief of Thorax 1 year ago we were fully aware of the enormous responsibility that came with the role as well as the challenges that we would face as the editorial team. We were wholly cognisant that we were representing more than just a journal, but indeed we were representing an important national body, the British Thoracic Society (BTS). Our key aims were to focus on originality, excellence and rigour in respiratory, sleep and critical care medicine to ensure that Thorax delivers interesting, educational and impactful content to all its readers, most importa...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Hart, N., Jenkins, G., Smyth, A. R. Tags: Editorial Source Type: research

Are welders more at risk of respiratory infections?
Welding of metals generates a complex mix of noxious gases and fumes,1 and has been linked with various respiratory diseases including metal fume fever,2 asthma,3 COPD4 and possibly bronchial carcinoma.1 2 In addition, there is now strong and consistent epidemiological evidence that welders are at increased risk of infectious, lobar pneumonia. Originally detected in national analyses of occupational mortality,5 the hazard was confirmed by a large case–control study of men admitted to hospitals in the English West Midlands with community-acquired pneumonia,6 and is supported by findings from more recent epidemiologica...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Coggon, D., Palmer, K. T. Tags: Editorial Source Type: research

CT-diagnosed emphysema and lung cancer mortality: novel association or old news?
Hippocrates may well have appreciated the significance of the presence of emphysema, but it was not until the 17th century that Bonet1 described the larger lungs of those with emphysema, to which he attributed their breathlessness. In 1821, Laennec connected emphysema to ageing, when he ascribed a subtly different definition to emphysema, describing it as "a breakdown of tissue in the parenchyma of the lungs as opposed to air trapped in the alveoli due to obstruction as occurs in asthma and chronic bronchitis" essentially considering emphysema to be an ‘independent finding’ to obstructive lung disease, although...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Quint, J. K. Tags: Editorial Source Type: research

From latent to active TB: are IGRAs of any use?
In May 2014, the World Health Assembly approved the WHO End TB Strategy which set ambitious targets for the elimination of tuberculosis (TB), including a 95% reduction in TB deaths and a 90% reduction in TB incidence by 2035.1 In December 2015, WHO Guidelines for low-TB-burden countries for the management of latent Mycobacterium tuberculosis (MTB) infection (LTBI) were published in support of the WHO End TB Strategy.2 A major focus of these guidelines is the identification of people with LTBI and the provision of chemoprophylaxis to prevent the development of active TB in those infected. Latent TB infection is defined as a...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Lim, W. S. Tags: Editorial Source Type: research

Metformin in severe exacerbations of chronic obstructive pulmonary disease: a randomised controlled trial
Conclusion Metformin did not ameliorate elevations in blood glucose concentration among non-diabetic patients admitted to hospital for COPD exacerbations, and had no detectable effect on CRP or clinical outcomes. Trial registration number ISRCTN66148745 and NCT01247870. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Hitchings, A. W., Lai, D., Jones, P. W., Baker, E. H., on behalf of the Metformin in COPD Trial Team, on behalf of the Metformin in COPD Trial Team, Akunuri, Tumilty, Poloniecki, Balasanthiran, Caneja, Norrie, Weldring, Carungcong, Harrison, Bateman, Batt Tags: Clinical trials (epidemiology), Open access, Inflammation Chronic obstructive pulmonary disease Source Type: research

Low-pathogenicity Mycoplasma spp. alter human monocyte and macrophage function and are highly prevalent among patients with ventilator-acquired pneumonia
This study demonstrates a high prevalence of Mycoplasmataceae among patients with VAP, with a markedly lower prevalence among patients with suspected VAP in whom subsequent cultures refuted the diagnosis. The most common organism found, M. salivarium, is able to alter the functions of key immune cells. Mycoplasmataceae may contribute to VAP pathogenesis. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Nolan, T. J., Gadsby, N. J., Hellyer, T. P., Templeton, K. E., McMullan, R., McKenna, J. P., Rennie, J., Robb, C. T., Walsh, T. S., Rossi, A. G., Conway Morris, A., Simpson, A. J. Tags: Open access, Editor's choice, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine), Cardiothoracic surgery Critical care Source Type: research

Are welders more at risk of respiratory infections? Findings from a cross-sectional survey and analysis of medical records in shipyard workers: the WELSHIP project
Conclusions The observation that respiratory symptoms and consultations for respiratory infection in welders are more common in winter may indicate an enhanced vulnerability to a broad range of infections. If confirmed, this would have important implications for the occupational healthcare of a very large, global workforce. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Marongiu, A., Hasan, O., Ali, A., Bakhsh, S., George, B., Irfan, N., Minelli, C., Canova, C., Schofield, S., De Matteis, S., Cullinan, P. Tags: TB and other respiratory infections Occupational lung disease Source Type: research

Cost-effectiveness of FENO-based and web-based monitoring in paediatric asthma management: a randomised controlled trial
Conclusions Economically, web-based monitoring was preferred from a healthcare perspective, while the FENO-based strategy was preferred from a societal perspective, although in QALYs and costs no statistically significant changes were found as compared with standard care. As clinical outcomes also favoured the web-based and FENO-based strategies, these strategies may be useful additions to standard care. Trial registration number Netherlands Trial Register (NTR1995). (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Beerthuizen, T., Voorend-van Bergen, S., van den Hout, W. B., Vaessen-Verberne, A. A., Brackel, H. J., Landstra, A. M., van den Berg, N. J., de Jongste, J. C., Merkus, P. J., Pijnenburg, M. W., Sont, J. K. Tags: Health policy, Clinical trials (epidemiology), Child health, Asthma, Health service research Paediatric lung disease Source Type: research

Majority of never-smokers with airflow limitation do not have asthma: the Copenhagen General Population Study
Conclusions Majority of NS+AFL–A do not seem to have undiagnosed asthma and may instead have airflow limitation caused by other risk factors. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Colak, Y., Afzal, S., Nordestgaard, B. G., Lange, P. Tags: Lung neoplasms, Epidemiologic studies, Pneumonia (infectious disease), TB and other respiratory infections, Lung cancer (oncology), Ischaemic heart disease, Asthma, Lung cancer (respiratory medicine), Pneumonia (respiratory medicine) Paediatric lung dis Source Type: research

Per cent emphysema is associated with respiratory and lung cancer mortality in the general population: a cohort study
Conclusions Quantitatively assessed emphysema on CT is associated with greater respiratory disease and lung cancer mortality, even among persons without traditional risk factors. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Oelsner, E. C., Carr, J. J., Enright, P. L., Hoffman, E. A., Folsom, A. R., Kawut, S. M., Kronmal, R. A., Lederer, D. J., Lima, J. A. C., Lovasi, G. S., Smith, B. M., Shea, S. J., Barr, R. G. Tags: Lung neoplasms, Epidemiologic studies, Lung cancer (oncology), Lung cancer (respiratory medicine), Health education, Smoking, Health effects of tobacco use, Tobacco use Respiratory epidemiology Source Type: research

The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activation
Conclusions These results reveal that TSA reduces allergen-induced ILC2 activation and the early innate immune responses to an inhaled protease-containing aeroallergen. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Toki, S., Goleniewska, K., Reiss, S., Zhou, W., Newcomb, D. C., Bloodworth, M. H., Stier, M. T., Boyd, K. L., Polosukhin, V. V., Subramaniam, S., Peebles, R. S. Tags: Open access, Inflammation, Asthma Respiratory research Source Type: research

Statin treatment is associated with a decreased risk of active tuberculosis: an analysis of a nationally representative cohort
Conclusions We found that statin therapy was associated with a decreased risk of active TB, and the length of statin therapy affected the TB protection. Given the observational nature of this study, the protective effect against active TB must be confirmed in future randomised trials. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Lai, C.-C., Lee, M.-t. G., Lee, S.-H., Hsu, W.-T., Chang, S.-S., Chen, S.-C., Lee, C.-C. Tags: Health policy, Epidemiologic studies, TB and other respiratory infections Tuberculosis Source Type: research

Prognostic value of interferon-{gamma} release assays, a population-based study from a TB low-incidence country
Conclusions We confirmed a high NPV of the QFT and found positive QFT associated with a higher risk of subsequent incident TB. Overall, the PPV for incident cases was 1.32%, and development of incident TB was associated with time interval after the QFT, but not with age. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Hermansen, T. S., Lillebaek, T., Langholz Kristensen, K., Andersen, P. H., Ravn, P. Tags: Epidemiologic studies Tuberculosis Source Type: research

Smokers are less likely than non-smokers to seek help for a lung cancer 'alarm symptom
Conclusions Delay in help-seeking in smokers for a symptom that is potentially indicative of lung cancer is a cause for concern. Future research could usefully address the psychological mechanisms through which help-seeking in smokers is hindered. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Friedemann Smith, C., Whitaker, K. L., Winstanley, K., Wardle, J. Tags: Health policy, Lung neoplasms, Open access, Lung cancer (oncology), Lung cancer (respiratory medicine), Ear, nose and throat/otolaryngology, Health service research, Health education, Smoking, Health effects of tobacco use, Tobacco use Research letter Source Type: research

Reduced physical activity in lymphangioleiomyomatosis compared with COPD and healthy controls: disease-specific impact and clinical correlates
Conclusions Physical activity in daily life is substatially reduced in LAM, when compared with healthy controls and COPD - indicating a disease specific impact. The regular assessment of fatigue and generic health status may improve disease management in LAM by taking daily physical activity of patients with LAM more adequately into account. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Bahmer, T., Watz, H., Waschki, B., Gramm, M., Magnussen, H., Rabe, K. F., Wirtz, H., Kirsten, D., Kirsten, A. Tags: Research letter Source Type: research

Obstructive sleep apnoea and frequency of occupational injury
Abstract We sought to determine whether patients with obstructive sleep apnoea (OSA) are at increased risk of occupational injury (OI). Patients referred to the University of British Columbia Hospital Sleep Laboratory for suspected OSA (May 2003 to July 2011 were recruited and rates and types of validated OI (that caused at least 1 day of disability) in the 5 years prior to polysomnography were calculated. In a sample of 1236, patients with OSA were twice as likely (OR=1.93, 95% CI 1.06 to 3.50, p=0.03) to suffer at least one OI compared with patients without OSA. This association was attenuated (OR=1.76, CI 0.86 to 3...
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Hirsch Allen, A. J., Park, J. E., Daniele, P. R., Fleetham, J., Ryan, C. F., Ayas, N. T. Tags: Research letter Source Type: research

Lesson of the month: selective use of cyclophosphamide in pregnancy for severe autoimmune respiratory disease
We present the cases of two pregnant women who developed severe respiratory compromise in mid pregnancy, one due to rapidly progressive interstitial lung disease associated with mixed connective tissue disease and one secondary to diffuse alveolar haemorrhage due to antiglomerular basement membrane disease. Both were treated with high-dose steroids followed by pulsed intravenous cyclophosphamide. Both women went onto have live births although one baby was growth restricted and preterm. Neither baby had any evidence of congenital abnormalities. (Source: Thorax)
Source: Thorax - June 14, 2016 Category: Respiratory Medicine Authors: Nelson-Piercy, C., Agarwal, S., Lams, B. Tags: Chemotherapy, Interstitial lung disease Chest clinic Source Type: research