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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.
Respiratory mechanics and ventilatory control in overlap syndrome and obesity hypoventilation
Johan Verbraecken and Walter McNicholas review the major pathophysiological mechanisms believed to contribute to the development of overlap syndrome (coexistant COPD and obstructive sleep apnea) and obesity hypoventilation syndrome (OHS), which share common pathways. (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2013 Category: Respiratory Medicine Authors: Johan VerbraeckenWalter McNicholas Source Type: research
Effect of sustained inflation versus step-wise PEEP strategy at birth on gas exchange and lung mechanics in preterm lambs.
Conclusions:An SEP at birth improved gas exchange, lung mechanics and EEV, without increasing lung injury, compared to the SI strategy used.Pediatric Research (2013); doi:10.1038/pr.2013.218. PMID: 24257321 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - November 20, 2013 Category: Pediatrics Authors: Tingay DG, Bhatia R, Schmölzer GM, Wallace MJ, Zahra VA, Davis PG Tags: Pediatr Res Source Type: research
OSAS affects liver histology and inflammatory cell activation in paediatric NAFLD, regardless of obesity/insulin resistance.
Conclusion. In paediatric NAFLD, OSAS is associated with biochemical, immunohistochemical and histological features of NASH and fibrosis. The impact of hypoxemia correction on liver disease severity warrants evaluation in future trials. PMID: 24256086 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 20, 2013 Category: Respiratory Medicine Authors: Nobili V, Cutrera R, Liccardo D, Pavone M, Devito R, Giorgio V, Verrillo E, Baviera G, Musso G Tags: Am J Respir Crit Care Med Source Type: research
Classification of Chronic Obstructive Pulmonary Disease Severity According to the New Global Initiative for Chronic Obstructive Lung Disease 2011 Guidelines: COPD Assessment Test Versus Modified Medical Research Council Scale.
CONCLUSIONS: The classification of patients with COPD using the assessment proposed by GOLD2011 varies according to the method used (CAT or mMRC); more than 25% of patients were reclassified into different categories, implying differences in the recommended therapeutic strategy. Longitudinal studies are needed to appraise which method better classifies patients, according to its prognostic ability. PMID: 24268434 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - November 20, 2013 Category: Respiratory Medicine Authors: Rieger-Reyes C, García-Tirado FJ, Rubio-Galán FJ, Marín-Trigo JM Tags: Arch Bronconeumol Source Type: research
Novel ABCA3 mutations as a cause of respiratory distress in a term newborn.
We report here the case of a term female newborn that developed severe respiratory distress soon after birth. She was found to be a compound heterozygote for both novel mutations in the ABCA3 gene. ABCA3 deficiency should be considered in mature babies who develop severe respiratory distress syndrome. PMID: 24269975 [PubMed - as supplied by publisher] (Source: Gene)
Source: Gene - November 20, 2013 Category: Genetics & Stem Cells Authors: Gonçalves JP, Pinheiro L, Costa M, Silva A, Gonçalves A, Pereira A Tags: Gene Source Type: research
Isolation and identification of bacteria capable of degrading euptox A from Eupatorium adenophorum Spreng.
Abstract Eupatorium adenophorum Spreng (E. adenophorum), an invasive plant which has caused widespread poisoning of livestock and crop failures in China. 9-oxo-10, 11-dehydroageraphorone (known as euptox A) is the main toxin causing a series of respiratory and digestive system diseases in animals. The purpose of the research is to isolate and identify the bacteria with the capacity of degrading euptox A, in which way could we lay the foundation in the utilization and prevention for E. adenophorum. Three strains of bacteria with the degradative characteristic are screened from E. adenophorum leaves, soil and goat's ...
Source: Toxicon - November 20, 2013 Category: Toxicology Authors: Liao F, Wang Y, Huang Y, Mo Q, Tan H, Wei Y, Hu Y Tags: Toxicon Source Type: research
Pharmacokinetic‐Pharmacodynamic Modeling in Anesthesia
Summary Anaesthesiologists adjust drug dosing, administration system and kind of drug to the characteristics of the patient. Then observe the expected response and adjust dosing to the specific requirements according to the difference between observed response, expected response and the context of the surgery and the patient. The approach above can be achieved because on one side quantification technology have made significant advances providing the anaesthesiologist to measure almost any effect by using noninvasive, continuous measuring systems. On the other because the knowledge on the relations between dosing, concentra...
Source: British Journal of Clinical Pharmacology - November 20, 2013 Category: Drugs & Pharmacology Authors: Pedro L. Gambús, Iñaki F. Trocóniz Tags: Review‐Themed Issue Source Type: research
Physicochemical and toxicological profiling of ash from the 2010 and 2011 eruptions of Eyjafjallajökull and Grímsvötn volcanoes, Iceland using a rapid respiratory hazard assessment protocol.
Abstract The six week eruption of Eyjafjallajökull volcano in 2010 produced heavy ash fall in a sparsely populated area of southern and south eastern Iceland and disrupted European commercial flights for at least 6 days. We adopted a protocol for the rapid analysis of volcanic ash particles, for the purpose of informing respiratory health risk assessments. Ash collected from deposits underwent a multi-laboratory physicochemical and toxicological investigation of their mineralogical parameters associated with bio-reactivity, and selected in vitro toxicology assays related to pulmonary inflammatory responses. Ash fr...
Source: Environmental Research - November 20, 2013 Category: Environmental Health Authors: Horwell CJ, Baxter PJ, Hillman SE, Calkins JA, Damby DE, Delmelle P, Donaldson K, Dunster C, Fubini B, Kelly FJ, Le Blond JS, Livi KJ, Murphy F, Nattrass C, Sweeney S, Tetley TD, Thordarson T, Tomatis M Tags: Environ Res Source Type: research
Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors.
Abstract To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-CoV activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of the Middle East respiratory syndrome (MERS)-CoV necessitates adapting methods that have been used to identify antivirals against the severe, acute respiratory syndrome (SARS)-CoV and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using in...
Source: Antiviral Research - November 20, 2013 Category: Virology Authors: Kilianski A, Baker SC Tags: Antiviral Res Source Type: research
SARS-CoV ORF1b-encoded nonstructural proteins 12-16: replicative enzymes as antiviral targets.
Abstract The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replicative-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27-32 kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., th...
Source: Antiviral Research - November 20, 2013 Category: Virology Authors: Subissi L, Imbert I, Ferron F, Collet A, Coutard B, Decroly E, Canard B Tags: Antiviral Res Source Type: research
Identification of human metapneumovirus genotypes A and B from clinical specimens by reverse transcription loop-mediated isothermal amplification.
Abstract Human metapneumovirus (hMPV) has been recognized as an important pathogen for acute respiratory infections in children worldwide and classified into genotypes A and B. Reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay is a rapid diagnostic method for detecting nucleic acids with a single step under isothermal conditions in less than 1h. RT-LAMP targeting the M gene of hMPV was developed for detecting and identifying hMPV genotypes A and B. The detection limit of the genotype-specific hMPV RT-LAMP assay was 10 times greater than that of conventional reverse transcription polymeras...
Source: Journal of Virological Methods - November 20, 2013 Category: Virology Authors: Song Q, Zhu R, Sun Y, Zhao L, Wang F, Deng J, Qian Y Tags: J Virol Methods Source Type: research
Targeting deficiencies in mitochondrial respiratory complex I and functional uncoupling exerts anti-seizure effects in a genetic model of temporal lobe epilepsy and in a model of acute temporal lobe seizures.
We report that MRCI-driven respiration and functional uncoupling (an inducible antioxidant mechanism) are reduced and levels of H2O2 are elevated in mitochondria isolated from KO mice. Experimental impairment of MRCI in WT hippocampal slices via rotenone reduces paired-pulse ratios (PPRs) at mossy fiber-CA3 synapses (resembling KO PPRs), and exacerbates seizure-like events in vitro. Daily treatment with AATP [a combination therapy composed of ascorbic acid (AA), alpha-tocopherol (T), sodium pyruvate (P) designed to synergistically target mitochondrial impairments] improved mitochondrial functions, mossy fiber PPRs, and red...
Source: Experimental Neurology - November 20, 2013 Category: Neurology Authors: Simeone KA, Matthews SA, Samson KK, Simeone TA Tags: Exp Neurol Source Type: research
Clinical use of pulse oximetry: Official guidelines from the Thoracic Society of Australia and New Zealand
Abstract Pulse oximetry provides a simple, non‐invasive approximation of arterial oxygenation in a wide variety of clinical settings including emergency and critical‐care medicine, hospital‐based and ambulatory care, perioperative monitoring, inpatient and outpatient settings, and for specific diagnostic applications. Pulse oximetry is of utility in perinatal, paediatric, adult and geriatric populations but may require use of age‐specific sensors in these groups. It plays a role in the monitoring and treatment of respiratory dysfunction by detecting hypoxaemia and is effective in guiding oxygen therapy in both adul...
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Jeffrey J. Pretto, Teanau Roebuck, Lutz Beckert, Garun Hamilton Tags: Clinical Practice Guidelines Source Type: research
CYFRA 21‐1 as a disease severity marker for autoimmune pulmonary alveolar proteinosis
ConclusionsSerum CYFRA 21‐1 is a sensitive and useful serum marker for diagnosis and evaluation of disease severity of APAP, and may predict the response to GM‐CSF inhalation. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Toru Arai, Yoshikazu Inoue, Chikatoshi Sugimoto, Yasushi Inoue, Keiko Nakao, Naoko Takeuchi, Akiko Matsumuro, Masaki Hirose, Koh Nakata, Seiji Hayashi Tags: Original Article Source Type: research
Pulmonary vascular limitation to exercise and survival in idiopathic pulmonary fibrosis
ConclusionsV'E/V'CO2, the only CPET parameter associated with elevated sPAP, appears a potentially useful non‐invasive marker for early detection of pulmonary vascular impairment, and therefore may be of use for a more accurate prognostic assessment in IPF patients. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Mart N. Plas, Coen Kan, Judith Blumenthal, Henk M. Jansen, Athol U. Wells, Paul Bresser Tags: Original Article Source Type: research
Detection of viruses and atypical bacteria associated with acute respiratory infection of children in Hubei, China
ConclusionsThe most common pathogens causing acute respiratory infection among children in Hubei of China were mycoplasma pneumonia, influenza virus B and respiratory syncytial virus. The detection rates for each pathogen displayed specific seasonal and age group variations. (Source: Respirology)
Source: Respirology - November 20, 2013 Category: Respiratory Medicine Authors: Zegang Wu, Yan Li, Jian Gu, Hongyun Zheng, Yongqing Tong, Qing Wu Tags: Original Article Source Type: research
The effects of a peer modeling intervention on cardiorespiratory fitness parameters and self-efficacy in obese adolescents.
This study examined the effect of a peer modeling intervention on cardiorespiratory fitness performance and task self-efficacy in obese youth completing a maximal treadmill test. Forty-nine obese (BMI ≥ 95th percentile for age and sex) youth were randomized to an experimental (received an intervention) or to a control group. The outcome variables were mean and variability cardiorespiratory fitness (peak VO2, heart rate, duration, respiratory exchange ratio), rating of perceived exertion, and task self-efficacy scores. Irrespective of whether a mean or variability score was used, receiving the intervention was associated ...
Source: Behavioral Medicine - November 19, 2013 Category: Psychiatry Authors: De Jesus S, Prapavessis H Tags: Behav Med Source Type: research
Perioperative Organ Injury
Despite the fact that a surgical procedure may have been performed for the appropriate indication and in a technically perfect manner, patients are threatened by perioperative organ injury. For example, stroke, myocardial infarction, acute respiratory distress syndrome, acute kidney injury, or acute gut injury are among the most common causes for morbidity and mortality in surgical patients. In the current review, the authors discuss the pathogenesis of perioperative organ injury, and provide select examples for novel treatment concepts that have emerged over the past decade. Indeed, the authors are of the opinion that res...
Source: Anesthesiology - November 19, 2013 Category: Anesthesiology Tags: Education: Review Article Source Type: research
Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes
Di Pierro F, Putignano P, Villanova N, Montesi L, Moscatiello S, Marchesini G (Source: International Journal of COPD)
Source: International Journal of COPD - November 19, 2013 Category: Respiratory Medicine Source Type: research
Sixty‐five years since the New York heat wave: Advances in sweat testing for cystic fibrosis
Summary The sweat test remains important as a diagnostic test for cystic fibrosis (CF) and has contributed greatly to our understanding of CF as a disease of epithelial electrolyte transport. The standardization of the sweat test, by Gibson and Cooke [Gibson and Cooke (1959) Pediatrics 1959;23:5], followed observations of excessive dehydration amongst patients with CF and confirmed the utility as a diagnostic test. Quantitative pilocarpine iontophoresis remains the gold standard for sweat induction, but there are a number of collection and analytical methods. The pathophysiology of electrolyte transport in sweat was descri...
Source: Pediatric Pulmonology - November 19, 2013 Category: Respiratory Medicine Authors: Jake T.B. Collie, R. John Massie, Oliver A.H. Jones, Vicky A. LeGrys, Ronda F. Greaves Tags: State of the Art Source Type: research
[Demonstration of Cryptosporidium parvum in Immune Suppressed Rats Using Nested PCR].
Conclusion: The results of the study showed that oral dexamethasone administration was more efficient in generating disseminated cryptosporidiosis in rats compared to subcutaneous dexamethasone administration. In addition, Nested PCR targeting 18S small-subunit rRNA gene can be used to detect Cryptosporidium spp. in respiratory and stool specimens of animals and humans. (Turkiye Parazitol Derg 2013; 37: 165-8). PMID: 24192616 [PubMed - in process] (Source: Turkish Society for Parasitology)
Source: Turkish Society for Parasitology - November 19, 2013 Category: Parasitology Authors: Can H, Caner A, Döşkaya M, Değirmenci A, Karaçalı S, Gürüz Y, Uner A Tags: Turkiye Parazitol Derg Source Type: research
The inclusion of N-Terminal pro-brain natriuretic peptide in a sensitive screening strategy for systemic sclerosis-related pulmonary arterial hypertension: a cohort study
Conclusions: The combination of NT-proBNP with PFT is a sensitive, yet simple and non-invasive screening strategy for SSc-PAH. Patients with a positive screening result can be referred for echocardiography, and further confirmatory testing for PAH. In this way, it may be possible to shift the burden of routine screening away from echocardiography. The findings of this study should be confirmed in larger studies. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - November 19, 2013 Category: Rheumatology Authors: Vivek ThakkarWendy StevensDavid PriorPeter YoussefDanny LiewEli GabbayJanet RoddyJennifer WalkerJane ZochlingJoanne SahharPeter NashSusan LesterMaureen RischmuellerSusanna ProudmanMandana Nikpour Source Type: research
Chronic bronchitis in COPD patients is associated with increased risk of exacerbations: a cross‐sectional multicentre study
ConclusionsCB prevalence in GOLD stage 2–4 COPD patients is high. CB is related to current tobacco smoking, and prevalence increases with COPD severity and duration, emphysema and age. CB could be the hallmark of a subtype of COPD easy to identify in clinical practice, associated with increased disease severity and increased risk of exacerbation. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - November 19, 2013 Category: Internal Medicine Authors: J. L. Corhay, W. Vincken, M. Schlesser, P. Bossuyt, J. Imschoot Tags: Original Paper Source Type: research
Preserving spontaneous breathing during mechanical ventilatory support: an old yet fascinating story
Facilitation of early spontaneous breathing activity is the most important measure to shorten weaning and avoid ventilator-induced lung injury and diaphragmatic injury in mechanically ventilated patients. However, the optimal degree of spontaneous muscle activity and ventilator support remains to be determined. Furthermore, effectiveness in relation to the pathophysiology of respiratory failure is unclear. In this regard the experimental study by Saddy and colleagues reveals interesting insights into the pathophysiology of ventilator-induced injury. More important, their results raise important questions that should be eva...
Source: Critical Care - November 19, 2013 Category: Intensive Care Authors: Enrico CalziaRolf Dembinski Source Type: research
Need to evaluate the performance of real-time PCR assays for the quantitation of cytomegalovirus DNA load in lower respiratory tract specimens
No description available (Source: Critical Care)
Source: Critical Care - November 19, 2013 Category: Intensive Care Authors: María ClariEstela GiménezGerardo AguilarIsabel CorralesJuan AlberolaDavid Navarro Source Type: research
Assembly factors for the membrane arm of complex I [Cell Biology]
Mitochondrial respiratory complex I is a product of both the nuclear and mitochondrial genomes. The integration of seven subunits encoded in mitochondrial DNA into the inner membrane, their association with 14 nuclear-encoded membrane subunits, the construction of the extrinsic arm from 23 additional nuclear-encoded proteins, iron–sulfur clusters, and flavin mononucleotide... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - November 19, 2013 Category: Science Authors: Andrews, B., Carroll, J., Ding, S., Fearnley, I. M., Walker, J. E. Tags: Biological Sciences Source Type: research
The hypoxic ventilatory response and trpa1 antagonism in conscious mice
ConclusionsThe study unraveled the role of TRPA1 in shaping the ventilatory response to low intensity hypoxia, liable to be mediated by vagally innervated respiratory chemosensors of lower functional rank, but contradicted the TRPA1 being indispensable for the powerful carotid body chemoreflex in face of a severe hypoxic threat.This article is protected by copyright. All rights reserved. (Source: Acta Physiologica)
Source: Acta Physiologica - November 19, 2013 Category: Physiology Authors: Mieczyslaw Pokorski, Kotaro Takeda, Yutaka Sato, Yasumasa Okada Tags: Regular Paper Source Type: research
One case of swine hepatitis E virus and porcine reproductive and respiratory syndrome virus Co-infection in weaned pigs
Conclusions: We have detected HEV and PRRSV co-infection in one piglet. Severe pathologic changes were observed. The high mortality of weaned pigs which showed the similar clinical syptom was possibly a result of HEV and PRRSV co-infection, which has rarely been reported previously. We speculated that co-infection with PRRSV and HEV might lead to more serious problems. (Source: Virology Journal)
Source: Virology Journal - November 19, 2013 Category: Virology Authors: Jingjing MaoYue ZhaoRuiping ShePeng XiaoJijing TianJian Chen Source Type: research
Classical Transient Receptor Potential Channel 1 in Hypoxia-induced Pulmonary Hypertension.
Conclusion: Our results indicate an important role of TRPC1 in pulmonary vascular remodeling underlying the development of hypoxia-induced PH. PMID: 24251695 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 19, 2013 Category: Respiratory Medicine Authors: Malczyk M, Veith C, Fuchs B, Hofmann K, Storch U, Schermuly RT, Witzenrath M, Ahlbrecht K, Fecher-Trost C, Flockerzi V, Ghofrani HA, Grimminger F, Seeger W, Gudermann T, Dietrich A, Weissmann N Tags: Am J Respir Crit Care Med Source Type: research
Regulation of IL-4 Receptor Signaling by STUB1 in Lung Inflammation.
Conclusions: Our study identified a previously uncharacterized role for STUB1 in regulating IL-4R signaling, which might provide a new strategy for attenuating airway inflammation. PMID: 24251647 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 19, 2013 Category: Respiratory Medicine Authors: Wei Q, Sha Y, Bhattacharya A, Fattah EA, Bonilla D, Jyothula SS, Pandit L, Khurana Hershey GK, Eissa NT Tags: Am J Respir Crit Care Med Source Type: research
Persistent Effects of Maternal Smoking during Pregnancy on Lung Function and Asthma in Adolescents.
Conclusions: Maternal smoking in pregnancy increases risk of asthma and wheezing in adolescence; mechanisms go beyond reducing lung function and exclude altering immune function or enhancing atopy. PMID: 24251622 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 19, 2013 Category: Respiratory Medicine Authors: Hollams EM, de Klerk NH, Holt PG, Sly PD Tags: Am J Respir Crit Care Med Source Type: research
Regulation of Hypoxia-Induced Pulmonary Hypertension by Vascular Smooth Muscle HIF-1alpha.
Conclusions: These results indicate that HIF-1α in smooth muscle contributes to pulmonary vascular remodeling and pulmonary hypertension in chronic hypoxia. However, loss of HIF-1 function in smooth muscle does not affect hypoxic cardiac remodeling, suggesting that the cardiac hypertrophy response is not directly coupled to the increase in pulmonary artery pressure. PMID: 24251580 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 19, 2013 Category: Respiratory Medicine Authors: Ball MK, Waypa GB, Mungai PT, Nielsen JM, Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK, Steinhorn RH, Shah SJ, Schumacker PT Tags: Am J Respir Crit Care Med Source Type: research
Synthetic Aminoglycosides Efficiently Suppress CFTR Nonsense Mutations and are Enhanced by Ivacaftor.
Abstract New drugs are needed to enhance premature termination codon (PTC) suppression to treat the underlying cause of cystic fibrosis (CF) and other diseases caused by nonsense mutations. We tested new synthetic aminoglycoside derivatives expressly developed for PTC suppression in a series of complementary CF models. Using a dual-luciferase reporter system containing the four most prevalent CFTR nonsense mutations (G542X, R553X, R1162X and W1282X) within their local sequence contexts (the three codons on either side of the PTC), we found that NB124 promoted the most readthrough of G542X, R1162X and W1282X PTCs. N...
Source: Am J Respir Cell Mol... - November 19, 2013 Category: Respiratory Medicine Authors: Xue X, Mutyam V, Tang L, Biswas S, Du M, Jackson LA, Dai Y, Belakhov V, Shalev M, Chen F, Schacht J, Bridges R, Baasov T, Hong J, Bedwell DM, Rowe SM Tags: Am J Respir Cell Mol Biol Source Type: research
Atomic force microscopic investigation of respiratory syncytial virus infection in HEp‐2 cells
We report the cytoplasmic and nuclear changes in human epidermoid cell line type 2 using atomic force microscopy. Human epidermoid cell line type 2 cells, grown on cover slips, were infected with RSV and fixed after various time periods, processed and observed for morphological changes using atomic force microscopy. RSV infected cells showed loss of membrane integrity, with degeneration in the cellular content and cytoskeleton. Nuclear membrane was disintegrated and nuclear volume was decreased. The chromatin of the RSV infected cells was condensed, progressing towards degeneration via pyknosis and apoptosis. Membrane prot...
Source: Journal of Microscopy - November 19, 2013 Category: Laboratory Medicine Authors: P.M. TIWARI, E. EROGLU, S. BOYOGLU‐BARNUM, Q. HE, G.A. WILLING, K. VIG, V.A. DENNIS, S.R. SINGH Tags: Original Article Source Type: research
Patient and hospital factors associated with induction mortality in acute lymphoblastic leukemia
ConclusionsThe overall risk of induction death is low but substantially increased in patients with cardio‐respiratory and other organ failures. Induction mortality varies up to three‐fold across hospitals and is correlated with hospital payer mix. Further work is needed to improve induction outcomes in hospitals with higher mortality. These data suggest an induction mortality rate of less than 1% may be an attainable national benchmark. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 19, 2013 Category: Cancer & Oncology Authors: Alix E. Seif, Brian T. Fisher, Yimei Li, Kari Torp, Douglas P. Rheam, Yuan‐Shung V. Huang, Tracey Harris, Ami Shah, Matthew Hall, Evan S. Fieldston, Marko Kavcic, Marijana Vujkovic, L. Charles Bailey, Leslie S. Kersun, Anne F. Reilly, Susan R. Rheingold Tags: Research Article Source Type: research
Solirubrobacter phytolaccae sp. nov., a novel endophytic bacterium isolated from the root of Phytolacca acinosa Roxb.
Abstract A Gram-staining-positive, strictly aerobic, rod-shaped, non-motile, non-spore-forming and white-coloured bacterial strain, designated GTGR-8T, was isolated from the root of Phytolacca acinosa Roxb. collected from Taibai Mountain in Shaanxi Province, north-west China. Strain GTGR-8T grew optimally at 28-30 °C, at pH 7.0-8.0, and in the absence of NaCl. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain GTGR-8T was a member of the genus Solirubrobacter and was closely related to Solirubrobacter pauli B33D1T (98.9 %), Solirubrobacter ginsenosidimutans BXN5-15T (97.0 %) and Solirubrobac...
Source: International Journal of Systematic and Evolutionary Microbiology - November 19, 2013 Category: Microbiology Authors: Wei L, Ouyang S, Wang Y, Shen X, Zhang L Tags: Int J Syst Evol Microbiol Source Type: research
Insufficient preparedness of primary care practices for pandemic influenza and the effect of a preparedness plan in Japan: a prefecture-wide cross-sectional study
Conclusions: With regard to PPE availability, PCPs (especially clinic-based PCPs) were not adequately prepared for the influenza pandemic. Awareness of the national pandemic preparedness plan is likely to promote prefecture-wide implementation of BCPs and surveillance activity. (Source: BMC Family Practice)
Source: BMC Family Practice - November 19, 2013 Category: Primary Care Authors: Taro TomizukaYasuhiro KanataniKazuo Kawahara Source Type: research
Computer quantification of airway collapse on forced expiration to predict the presence of emphysema
Conclusions: Airway collapse on forced expiration quantified by a computer model correlates with emphysema. An AC below 131[degree sign] can be considered as a specific cut-off for predicting the presence of emphysema in heavy smokers. (Source: Respiratory Research)
Source: Respiratory Research - November 19, 2013 Category: Respiratory Medicine Authors: Marko TopalovicVasileios ExadaktylosAnneleen PeetersJohan CoolenWalter DeweverMartijn HemeryckPieter SlagmolenKarl JanssensDaniel BerckmansMarc DecramerWim Janssens Source Type: research
Circulating levels of copeptin predict outcome in patients with pulmonary arterial hypertension
Conclusions: Patients with PAH had elevated copeptin levels. High circulating levels of copeptin were independent predictors of poor outcome, which makes copeptin a potentially useful biomarker in PAH. (Source: Respiratory Research)
Source: Respiratory Research - November 19, 2013 Category: Respiratory Medicine Authors: Nils NickelRalf LichtinghagenHeiko GolponKaren OlssonKorbinian BrandTobias WelteMarius Hoeper Source Type: research