Respiratory Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

The Effects of Vitamin D Deficiency in Athletes
Vitamin D acts to maintain calcium and phosphate homeostasis within the body. It is now estimated that 1 billion people worldwide are vitamin D deficient. This problem is particularly important to athletes of all ages, as vitamin D plays a significant role in bone health, immune function, and physical performance. In the deficient state, the athlete may be at an increased risk for potential problems such as stress fractures, respiratory infections, and muscle injuries. The purpose of this article is to examine vitamin D deficiency and review its relationship to the athlete.
Source: The American Journal of Sports Medicine - January 31, 2013 Category: Sports Medicine Authors: Angeline, M. E., Gee, A. O., Shindle, M., Warren, R. F., Rodeo, S. A. Tags: Epidemiology, Muscle, Nonoperative Current Concepts Source Type: research

An interesting application of lung ultrasonography
In the previous issue of Critical Care, Raimondi and colleagues investigate whether lung ultrasonography has utility for the assessment of respiratory distress in the neonate. This commentary reviews the results and implications of their study.
Source: BioMed Central - January 31, 2013 Category: Journals (General) Authors: Paul H Mayo Source Type: research

Obstructive sleep apnea: should weight loss be prescribed?
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 1-3.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Review article: extubation of the difficult airway and extubation failure.
Abstract Respiratory complications after tracheal extubation are associated with significant morbidity and mortality, suggesting that process improvements in this clinical area are needed. The decreased rate of respiratory adverse events occurring during tracheal intubation since the implementation of guidelines for difficult airway management supports the value of education and guidelines in advancing clinical practice. Accurate use of terms in defining concepts and describing distinct clinical conditions is paramount to facilitating understanding and fostering education in the treatment of tracheal extubation-rel...
Source: Anesthesia and Analgesia - January 30, 2013 Category: Anesthesiology Authors: Cavallone LF, Vannucci A Tags: Anesth Analg Source Type: research

New technique to identify cause of respiratory illnesses
Georgia Regents Health System physicians have developed what they say is a quick, thorough method to identify the viruses and bacteria causing respiratory illness. Within an hour, the technique, called polymerase chain reaction (PCR), determines which of 21 common viruses and bacteria are causing coughing, hacking, wheezing and other respiratory symptoms. That information tells physicians how best to treat – or not treat – the illness. It’s also giving physicians an accurate snapshot of circulating…
Source: bizjournals.com Health Care:Hospitals headlines - January 30, 2013 Category: Hospital Management Authors: Urvaksh Karkaria Source Type: research

Association between latitude and allergic diseases: a longitudinal study from childhood to middle-age.
CONCLUSION: This is the first study, to our knowledge, to demonstrate a differential effect of atopic status on the relationship between latitude and current asthma. Our study demonstrates in a genetically and culturally similar group of individuals that geographic factors may a play role in the development of allergic disease. PMID: 23352525 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Oktaria V, Dharmage SC, Burgess JA, Simpson JA, Morrison S, Giles GG, Abramson MJ, Walters EH, Matheson MC Tags: Ann Allergy Asthma Immunol Source Type: research

Characterization of aspirin allergies in patients with coronary artery disease.
CONCLUSION: Histories of aspirin reactions in patients with CAD are uncommon, occurring in only 1.5% of our study population. The 21% of patients with histories compatible with aspirin hypersensitivities can be challenged and, if the results are positive, successfully desensitized. Moreover, almost all patients with gastric intolerance to aspirin can be treated with aspirin and a proton pump inhibitor. However, both approaches, which result in restoration of cardiovascular prophylaxis, were seriously underused in our study population. PMID: 23352527 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Feng CH, White AA, Stevenson DD Tags: Ann Allergy Asthma Immunol Source Type: research

Anaphylaxis in a tertiary adult allergy clinic: a retrospective review of 516 patients.
CONCLUSION: In this study, the second pattern of National Institute of Allergy and Infectious Disease (NIAID) and the Food Allergy and Anaphylaxis Network (FAAN) diagnostic criteria for anaphylaxis predominated among adult patients. Drugs were the leading triggering factor, followed by Hymenoptera stings, foods, latex, and exercise, respectively. Atopy, asthma, and allergic rhinitis were rarely detected. PMID: 23352528 [PubMed - in process]
Source: Annals of Allergy, Asthma and Immunology - January 30, 2013 Category: Allergy & Immunology Authors: Gelincik A, Demirtürk M, Yılmaz E, Ertek B, Erdogdu D, Colakoğlu B, Büyüköztürk S Tags: Ann Allergy Asthma Immunol Source Type: research

Mepolizumab for severe eosinophilic asthma
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 13-17.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

The emergence of new therapeutic targets in pulmonary arterial hypertension: from now to the near future
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 43-55.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

The role of systemic inflammatory biomarkers to predict mortality in chronic obstructive pulmonary disease
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 57-64.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Eosinophils as diagnostic tools in chronic lung disease
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 33-42.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

News in brief
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 9-11.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Acknowledgements
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 99-99.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Combined pulmonary fibrosis and emphysema
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 19-32.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Severity scores in community-acquired pneumonia: how useful are they?
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 5-7.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Hemoptysis with diagnostic dilemma
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 91-97.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Managing an acutely ill patient with pulmonary arterial hypertension
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 77-83.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Effect of inhaled dry powder mannitol on mucus and its clearance
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 65-75.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Use of endobronchial valves in persistent air leaks: a case report and review of the literature
Expert Review of Respiratory Medicine , February 2013, Vol. 7, No. 1, Pages 85-90.
Source: Expert Review of Respiratory Medicine - January 30, 2013 Category: Respiratory Medicine Tags: article Source Type: research

A Phase 1, randomized, open-label crossover study to evaluate the safety and pharmacokinetics of 400 mg albaconazole administered to healthy participants as a tablet formulation versus a capsule formulation
van Rossem K, Lowe JA
Source: International Journal of COPD - January 30, 2013 Category: Respiratory Medicine Source Type: research

The relationship between bronchial hyperresponsiveness and lung function, in children age five and six with and without asthma
ConclusionsOur data suggest that it not possible to distinguish children with asthma from non‐asthmatic wheezers based on their bronchial sensitivity. The baseline Rrs has a stong effect on the bronchial reactivity in children.
Source: Respirology - January 30, 2013 Category: Respiratory Medicine Authors: Satoru Takami, Hiroyuki Mochizuki, Reiko Muramatsu, Satomi Hagiwara, Hirokazu Arakawa Tags: Original Article Source Type: research

Purinergic regulation of CFTR and Ca2+-activated Cl- channels and K+ channels in human pancreatic duct epithelium.
Abstract Purinergic agonists have been considered for the treatment of respiratory epithelia in cystic fibrosis (CF) patients. Pancreas, one of the most seriously affected organs in CF, express various purinergic receptors. Studies on rodent pancreas show that purinergic signalling regulates pancreatic secretion. In the present study, we aim to identify Cl(-) and K(+) channels in human pancreatic ducts and their regulation by purinergic receptors. Human pancreatic duct epithelia formed by Capan-1 or CFPAC-1 cells were studied in open-circuit Ussing chambers. In Capan-1 cells, ATP/UTP effects were dependent on intra...
Source: American Journal of Physiology. Cell Physiology - January 30, 2013 Category: Cytology Authors: Wang J, Haanes KA, Novak I Tags: Am J Physiol Cell Physiol Source Type: research

Effects of high temperature and exposure to air on mussel (Mytilus galloprovincialis, Lmk 1819) hemocyte phagocytosis: Modulation of spreading and oxidative response.
Abstract Hemocytes are a critical component of the mussel defense system and the present study aims at investigating their spreading and oxidative properties during phagocytosis under in vivo experimental stress conditions. The spreading ability was measured by an automated cell analyzer on the basis of the circularity, a parameter corresponding to the hemocyte roundness. The oxidative activity was investigated by micromethod assay, measuring the respiratory burst as expression of the fluorescence generated by the oxidation of specific probe. Following the application of high temperature and exposure to air, there ...
Source: Tissue and Cell - January 30, 2013 Category: Cytology Authors: Mosca F, Narcisi V, Calzetta A, Gioia L, Finoia MG, Latini M, Tiscar PG Tags: Tissue Cell Source Type: research

Mitochondrial Morphology Transitions and Functions: Implications for Retrograde Signaling?
Abstract In response to cellular and environmental stresses, mitochondria undergo morphology transitions regulated by dynamic processes of membrane fusion and fission. These events of mitochondrial dynamics are central regulators of cellular activity, but the mechanisms linking mitochondrial shape to cell function remain unclear. One possibility evaluated in this article is that mitochondrial morphological transitions (from elongated to fragmented, and vice-versa) directly modify canonical aspects of the organelle's function, including susceptibility to mitochondrial permeability transition, respiratory properties ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 30, 2013 Category: Physiology Authors: Picard M, Shirihai OS, Gentil BJ, Burelle Y Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Patients' and providers' perceptions of the impact of health literacy on communication in pulmonary rehabilitation.
This study was designed to explore the patients' and health care professionals' (HCPs) perceptions of the role of HL in health communication.Semi-structured interviews and focus groups were conducted with 12 patients and 20 HCPs at a Pulmonary Rehabilitation Center in Metropolitan Toronto.Although the term health literacy was not familiar to many patients, the contribution of knowledge to patient well-being was consistently identified by patients and HCPs. Barriers to communication included provider time constraints and the use of medical jargon. For providers they also included patient characteristics, language, culture a...
Source: Chronic Respiratory Disease - January 30, 2013 Category: Respiratory Medicine Authors: Sadeghi S, Brooks D, Goldstein RS Tags: Chron Respir Dis Source Type: research

Neonatal Paracorporeal Lung Assist Device for Respiratory Failure [CASE REPORTS]
Neonates who experience respiratory failure despite maximal ventilatory support have only extracorporeal membrane oxygenation as a rescue therapy, but it has very poor outcomes as a bridge to transplantation. A pumpless lung-assist device has been used in adults as a bridge to lung transplantation. An alternative membrane oxygenator, the Quadrox iD, is a suitable size for neonatal blood flow. Here we report the use of the Quadrox iD membrane oxygenator with central cannulation as a paracorporeal respiratory support therapy for a neonate with alveolar capillary dysplasia awaiting lung transplantation.
Source: The Annals of Thoracic Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Hoganson, D. M., Gazit, A. Z., Sweet, S. C., Grady, R. M., Huddleston, C. B., Eghtesady, P. Tags: Lung - transplantation, Mechanical Circulatory Assistance CASE REPORTS Source Type: research

Cerebral and Somatic Oxygen Saturations After Repair of Tetralogy of Fallot: Effects of Extubation on Regional Blood Flow [ORIGINAL ARTICLES: CONGENITAL HEART SURGERY]
Conclusions Cardiac output and cerebral oxygenation increased significantly during spontaneous respiration, the latter suggesting that the brain was in or approaching an oxygen supply-dependent state before extubation. Despite the increase in cardiac output, the presumed increase in respiratory pump perfusion, as well as the concurrent increase in cerebral perfusion, came at the expense of mesenteric perfusion. Renal oxygenation remained unchanged with extubation.
Source: The Annals of Thoracic Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Bronicki, R. A., Checchia, P. A., Anas, N. G., Adams, G. J., Penny, D. J., Bleiweis, M. S., Shekerdemian, L. S. Tags: Cardiac - physiology ORIGINAL ARTICLES: CONGENITAL HEART SURGERY Source Type: research

Decannulation in Tracheal Stenosis Deemed Inoperable Is Possible After Long-Term Airway Stenting [ORIGINAL ARTICLES: GENERAL THORACIC]
Conclusions Tracheal stenting may be considered a curative therapeutic approach in as many as 27.5% of patients with inoperable benign tracheal stenosis.
Source: The Annals of Thoracic Surgery - January 30, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Terra, R. M., Bibas, B. J., Minamoto, H., Waisberg, D. R., Tamagno, M. F. L., Tedde, M. L., Pego-Fernandes, P. M., Jatene, F. B. Tags: Trachea and bronchi ORIGINAL ARTICLES: GENERAL THORACIC Source Type: research

Purification, crystallization and preliminary crystallographic studies of haemoglobin from mongoose (Helogale parvula) in two different crystal forms induced by pH variation
Haemoglobin (Hb) is a respiratory pigment; it is a tetrameric protein that ferries oxygen from the lungs to tissues and transports carbon dioxide on the return journey. The oxygen affinity of haemoglobin is regulated by the concentration of oxygen surrounding it and several efforts have revealed the shapes of Hb in different states and with different functions. However, study of the molecular basis of Hbs from low-oxygen-affinity species is critically needed in order to increase the understanding of the mechanism behind oxygen adaptation. The present study reports the preliminary crystallographic study of low-oxygen-affini...
Source: Acta Crystallographica Section F - January 30, 2013 Category: Biochemistry Authors: Mohamed Abubakkar, M.Saraboji, K.Ponnuswamy, M.N. Tags: haemoglobin oxygen affinity pH Helogale parvula crystallization communications Source Type: research

Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim) -- a prospective, placebo-controlled, double-blind study
Conclusions: Filgrastim treatment is associated with increased circulating HBP levels compared to placebo, but the absolute neutrophil count or the degree of oxygenation failure did not correlate with the observed plasma HBP --concentrations.Trial registration: Clinicaltrials.gov NCT01713309
Source: BMC Infectious Diseases - January 30, 2013 Category: Infectious Diseases Authors: Kirsi-Maija KaukonenHeiko HerwaldLennart LindbomVille Pettila Source Type: research

Medication adherence and persistence in the treatment of Canadian ulcerative colitis patients: analyses with the RAMQ database
Conclusions: The majority of patients with UC exhibited low adherence and persistence to mesalamine treatments. Various determinants of improved adherence and persistence were identified.
Source: BMC Gastroenterology - January 30, 2013 Category: Gastroenterology Authors: Jean LachaineLinnette YenCatherine BeaucheminPaul Hodgkins Source Type: research

Image-based response assessment of liver metastases following stereotactic body radiotherapy with respiratory tracking
Conclusion: Use of response criteria based on change in size alone in the interpretation of liver response to SBRT may be inadequate. We propose a simple algorithm with a combination of criteria to better assess tumor response. Further studies are needed to confirm their validity.
Source: Radiation Oncology - January 30, 2013 Category: Cancer & Oncology Authors: Hajer JarrayaXavier MirabelSophie TaiebSylvain DewasEmmanuelle TreschFrancois BonodeauAntoine AdenisAndrew KramarEric LartigauLuc Ceugnart Source Type: research

The pathogenicity of avian metapneumovirus subtype C wild bird isolates in domestic turkeys
Conclusions: Our data demonstrate that aMPV/C wild bird isolates induced typical aMPV/C disease in the domestic turkeys.
Source: Virology Journal - January 30, 2013 Category: Virology Authors: Ra Mi ChaQingzhong YuLaszlo Zsak Source Type: research

Microbiologic and Cytologic Assessment of Bronchoalveolar Lavage Fluid from Dogs with Lower Respiratory Tract Infection: 105 Cases (2001–2011)
Conclusions and Clinical ImportanceConfirmation of lower respiratory tract infection in dogs is challenging and organisms can be isolated from dogs in which bacteria are not detected on cytologic examination.
Source: Journal of Veterinary Internal Medicine - January 30, 2013 Category: Veterinary Research Authors: L.R. Johnson, E.V. Queen, W. Vernau, J.E. Sykes, B.A. Byrne Tags: Standard Article Source Type: research

High hospital burden in overlap syndrome of asthma and COPD
ConclusionOverlap syndrome of asthma and COPD is a common condition with high hospital impact for patients with this condition.
Source: The Clinical Respiratory Journal - January 30, 2013 Category: Respiratory Medicine Authors: Heidi Andersén, Pekka Lampela, Antti Nevanlinna, Olli Säynäjäkangas, Timo Keistinen Tags: Original Article Source Type: research

Burden of childhood diseases and malnutrition in a semi-urban slum in southern India
Conclusions: Our study found a high burden of childhood diseases and malnutrition among urban slum dwellers in southern India. Frequent illnesses may adversely impact children's health and development, besides placing an additional burden on families who need to seek healthcare and find resources to manage illness.
Source: BMC Public Health - Latest articles - January 30, 2013 Category: Consumer Health News Authors: Rajiv SarkarPrabhu SivarathinaswamyBhuvaneshwari ThangarajKulandaipalayam SindhuSitara AjjampurJayaprakash MuliyilVinohar BalrajElena NaumovaHonorine WardGagandeep Kang Source Type: research

Health problems awareness during travel among faculty members of a large university in Latin America: preliminary report.
Abstract Health safety during trips is based on previous counseling, vaccination and prevention of infections, previous diseases or specific problems related to the destination. Our aim was to assess two aspects, incidence of health problems related to travel and the traveler's awareness of health safety. To this end we phone-interviewed faculty members of a large public University, randomly selected from humanities, engineering and health schools. Out of 520 attempts, we were able to contact 67 (12.9%) and 46 (68.6%) agreed to participate in the study. There was a large male proportion (37/44, 84.1%), mature adult...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - January 29, 2013 Category: Tropical Medicine Authors: Tome AC, Canello TB, Luna EJ, Andrade Junior HF Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Non‐invasively derived respiratory severity score and oxygenation index in ventilated newborn infants
ConclusionIn intubated newborn infants, there is a strong association between RSS and OI at SaO2 between 88% and 94%. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - January 29, 2013 Category: Respiratory Medicine Authors: Narayan P. Iyer, Maroun J. Mhanna Tags: Original Article: Neonatal Lung Disease Source Type: research

Antimicrobial peptide LL-37 attenuates LTA induced inflammatory effect in macrophages.
We examined TNF-α and IL-6 production after LL-37 treatment and discussed its signal transduction pathways such as p38MAPK and Akt activation in macrophages. The expression of pro-inflammatory cytokines was analyzed by quantitative real-time RT-PCR and enzyme-linked immunosorbent assay (ELISA). The LL-37 expression was determined by Western blot and immunofluorescence staining. The results showed that LL-37 was upregulated after LTA treatment. It could inhibit LTA induced p38MAPK and Akt phosphorylation and attenuate TNF-α and IL-6 production in macrophages in some specific concentration. These results suggest that LL-37...
Source: International Immunopharmacology - January 29, 2013 Category: Allergy & Immunology Authors: Ruan Y, Shen T, Wang Y, Hou M, Li J, Sun T Tags: Int Immunopharmacol Source Type: research

Fibrinogen and inflammatory cytokines in spontaneous sputum of sulfur-mustard-exposed civilians - Sardasht-Iran Cohort Study.
Abstract Sulfur mustard (SM) causes late complications in respiratory system of exposed individuals. In this preliminary study, the levels of IL-1α and β, TNF, IL-1Ra, IL-6 and fibrinogen in the spontaneous sputum of SM-exposed individuals were examined 20years after exposure and the correlation with pulmonary function was tested. The participants were categorized into two major subgroups (hospitalized and non-hospitalized) based on the severity of the clinical complications immediately after exposure. Every participant was visited by a physician; the respiratory functions were checked using spirometry and were c...
Source: International Immunopharmacology - January 29, 2013 Category: Allergy & Immunology Authors: Yaraee R, Hassan ZM, Pourfarzam S, Rezaei A, Faghihzadeh S, Ebtekar M, Soroush MR, Ardestani SK, Kazemi H, Mahmoudi M, Ghazanfari Z, Foroutan A, Jalaie S, Ghazanfari T Tags: Int Immunopharmacol Source Type: research

Salivary levels of secretary IgA, C5a and alpha 1-antitrypsin in sulfur mustard exposed patients 20years after the exposure, Sardasht-Iran Cohort Study (SICS).
In this study, as many as 500 volunteers, including 372 SM-exposed cases and 128 control volunteers were recruited. A 3ml sample of saliva was collected from each volunteer, and the level of secretory IgA, C5a, and alpha 1 antitrypsin in the samples were compared between the two groups. The SM-exposed group showed a significantly higher amount of salivary alpha 1 antitrypsin and secretary IgA compared to the control group (p<.006 and p<.018 respectively). The two groups showed no significant difference (p=0.192) in the level of C5a. The results also showed that the level of salivary A1AT is more than that of IgA in s...
Source: International Immunopharmacology - January 29, 2013 Category: Allergy & Immunology Authors: Yarmohammadi ME, Hassan ZM, Mostafaie A, Ebtekar M, Yaraee R, Pourfarzam S, Jalali-Nadoushan MR, Faghihzadeh S, Vaez-Ahdavi MR, Soroush MR, Khamesipour A, Faghihzadeh E, Sharifnia Z, Naghizadeh MM, Ghazanfari T Tags: Int Immunopharmacol Source Type: research

Sulfite-Mediated Oxidation of Myeloperoxidase to a Free Radical: Immuno-Spin Trapping Detection in Human Neutrophils.
The objective of the present study is to examine the oxidative damage caused by (bi)sulfite-derived free radicals in human neutrophils through formation of protein radicals. We used immuno-spin trapping and confocal microscopy to study the protein oxidations driven by sulfite-derived radicals. We found that the presence of sulfite can cause MPO-catalyzed oxidation of MPO to a protein radical in phorbol 12-myristate 13-acetate (PMA)-activated human neutrophils. We trapped the MPO-derived radicals in situ using the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO) and detected them immunologically as nitrone adducts ...
Source: Free Radical Biology and Medicine - January 29, 2013 Category: Biology Authors: Ranguelova K, Rice AB, Lardinois OM, Triquigneaux M, Steinckwich N, Deterding LJ, Garantziotis S, Mason RP Tags: Free Radic Biol Med Source Type: research

Gender and strain contributions to the variability of buprenorphine-related respiratory toxicity in mice.
Abstract While most deaths from asphyxia related to buprenorphine (BUP) overdose have been reported in males, higher plasma concentrations of BUP and its toxic metabolite norbuprenorphine (NBUP) have been observed in females. We previously demonstrated that P-glycoprotein (P-gp) modulation at the blood-brain barrier (BBB) contributes highly to BUP-related respiratory toxicity, by limiting NBUP entrance into the brain. In this work, we sought to investigate the role of P-gp-mediated transport at the BBB in gender and strain-related variability of BUP and NBUP-induced respiratory effects in mice. Ventilation was stud...
Source: Toxicology - January 29, 2013 Category: Toxicology Authors: Alhaddad H, Cisternino S, Saubamea B, Schlatter J, Chiadmi F, Risède P, Smirnova M, Cochois-Guégan V, Tournier N, Baud FJ, Mégarbane B Tags: Toxicology Source Type: research

PRIMARY CILIARY DYSKINESIA.
We present a case of 36-year-old woman with the history of recurrent lower respiratory tract infections and bronchiectasis. She was diagnosed with primary ciliary dyskinesia syndrome based on her clinical presentation and electron microscopy findings of her bronchial biopsy. PMID: 23362165 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 29, 2013 Category: Respiratory Medicine Authors: Ciftci F, Atilla P, Muftuoglu S, Karnak D Tags: Respir Care Source Type: research

SPONTANEOUS PULMONARY HERNIA: A CASE REPORT.
We describe the clinical features, diagnosis, and successful treatment. PMID: 23362166 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 29, 2013 Category: Respiratory Medicine Authors: Gómez PE, Ferreiro S, Esteban SM, Fodor R, Palavecino ME, Rios FG Tags: Respir Care Source Type: research

INDIVIDUALIZED POSITIVE END-EXPIRATORY PRESSURE SETTING IN PATIENTS WITH ACUTE RESPIRATORY DISTRESS SYNDROME. A RANDOMIZED CONTROLLED PILOT STUDY.
Conclusions:In ARDS patients, protective mechanical ventilation with PEEP application according to the highest compliance is associated with less organ dysfunction and a strong non-significant trend toward lower mortality. PMID: 23362167 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 29, 2013 Category: Respiratory Medicine Authors: Pintado MC, de Pablo R, Trascasa M, Milicua JM, Rogero S, Daguerre M, Cambronero JA, Arribas I, Sánchez-García M Tags: Respir Care Source Type: research

PREDICTING WALKING-INDUCED OXYGEN DESATURATIONS IN COPD PATIENTS: A STATISTICAL MODEL.
ConclusionsWDS accurately predicts and classifies the risk of walking desaturation in COPD patients. PMID: 23362168 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 29, 2013 Category: Respiratory Medicine Authors: Crisafulli E, Iattoni A, Venturelli E, Siscaro G, Beneventi C, Cesario A, Clini EM Tags: Respir Care Source Type: research

Diabetic myonecrosis in a cystic fibrosis patient.
We report the case of a 32 year old with poorly controlled diabetes presenting with subacute leg pain and focal quadriceps tenderness. The patient was found to have diabetic myonecrosis through careful neuromuscular testing and imaging after an extensive workup. This first reported case of diabetic myonecrosis in CF highlights the need for pulmonary physicians to recognize this diabetic complication in CF patients, which is associated with a poor long term prognosis and existing microvascular complications. PMID: 23362169 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 29, 2013 Category: Respiratory Medicine Authors: Kopp BT, Kirkby S, Hayes D, Flanigan KM Tags: Respir Care Source Type: research