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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Deleted in malignant brain tumors 1 (DMBT1) elicits increased VEGF and decreased IL-6 production in type II lung epithelial cells
Conclusions: The data indicate that DMBT1 promotes VEGF and suppresses IL-6 production in alveolar tissues, which could point to DMBT1 having a possible role in the transition from inflammation to regeneration and being a potentially useful clinical marker. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 8, 2015 Category: Respiratory Medicine Authors: Hanna MüllerChristian NagelChristel WeissJan MollenhauerJohannes Poeschl Source Type: research

Particulate Matter Composition and Respiratory Health: The PIAMA Birth Cohort Study
Conclusion: PM constituents, in particular iron, copper, and zinc, reflecting poorly regulated non-tailpipe road traffic emissions, may increase the risk of asthma and allergy in schoolchildren. (Source: Epidemiology)
Source: Epidemiology - April 7, 2015 Category: Epidemiology Tags: Air Pollution Source Type: research

The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome
Conclusion Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 7, 2015 Category: Respiratory Medicine Source Type: research

Expiratory positive airway pressure (EPAP) nasal device therapy: a welcome addition to obstructive sleep apnea syndrome therapy
(Source: Sleep and Breathing)
Source: Sleep and Breathing - April 7, 2015 Category: Respiratory Medicine Source Type: research

Mitochondrial DNA alteration in obstructive sleep apnea
Background: Obstructive Sleep Apnea (OSAS) is a disease associated with the increase of cardiovascular risk and it is characterized by repeated episodes of Intermittent Hypoxia (IH) which inducing oxidative stress and systemic inflammation. Mitochondria are cell organelles involved in the respiratory that have their own DNA (MtDNA). The aim of this study was to investigate if the increase of oxidative stress in OSAS patients can induce also MtDNA alterations. Methods: 46 OSAS patients (age 59.27 ± 11.38; BMI 30.84 ± 3.64; AHI 36.63 ± 24.18) were compared with 36 control subjects (age 54.42 ± 6.63; BMI 2...
Source: Respiratory Research - April 7, 2015 Category: Respiratory Medicine Authors: Donato LacedoniaGiovanna CarpagnanoElisabetta CrisettiGrazia CotugnoGrazia PalladinoGiulia PatricelliRoberto SabatoMaria Foschino Barbaro Source Type: research

Medical complications after lung transplantation
This article focuses on noninfectious, nonpulmonary medical complications seen postoperatively and discusses their impact on overall morbidity and mortality after lung transplantation. (Source: Current Respiratory Care Reports)
Source: Current Respiratory Care Reports - April 7, 2015 Category: Respiratory Medicine Source Type: research

Does the COPD assessment test (CAT TM ) questionnaire produce similar results when self- or interviewer administered?
Conclusions The mode of administration does not influence CAT scores or its psychometric properties. Hence, both modes of administration can be used in clinical practice depending on the physician judgment of patient’s capacity. (Source: Quality of Life Research)
Source: Quality of Life Research - April 7, 2015 Category: Health Management Source Type: research

External validation of scores proposed for estimation of survival probability of patients with severe adult respiratory distress syndrome undergoing extracorporeal membrane oxygenation therapy: a retrospective study
Conclusion: Our single-center validation confirms that the proposed PRESERVE- and RESP-score predict survival for patients treated with v-v ECMO for severe ARDS. (Source: Critical Care)
Source: Critical Care - April 7, 2015 Category: Intensive Care Authors: Stephanie KlinzingUrs WengerPeter SteigerChristoph StarckMarkus WilhelmReto SchuepbachMarco Maggiorini Source Type: research

The control of short-term feed intake by metabolic oxidation in late-pregnant and early lactating dairy cows exposed to high ambient temperatures
The objective of the present study was to integrate the dynamics of feed intake and metabolic oxidation in late pregnant and early lactating Holstein cows under heat stress conditions. On day 21 before parturition and again on day 20 after parturition, seven Holstein cows were kept for 7days at thermoneutral (TN) conditions (15°C; temperature–humidity-index (THI)=60) followed by a 7day heat stress (HS) period at 28°C (THI=76). On the last day of each temperature condition, gas exchange, feed intake and water intake were recorded every 6min in a respiration chamber. Pre- and post-partum cows responded to HS by decreasin...
Source: Physiology and Behavior - April 7, 2015 Category: Physiology Source Type: research

Survey-Defined Patient Experiences With Aspirin-Exacerbated Respiratory Disease
Conclusions Patients with AERD live with frustration and report a poor quality of life in spite of several pharmacologic treatments including aspirin desensitization followed by daily aspirin. Despite ongoing medical therapy, the burden of disease in AERD remains high. (Source: The Journal of Allergy and Clinical Immunology: In Practice)
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 7, 2015 Category: Allergy & Immunology Source Type: research

Asthma Control: The Right Inhaler for the Right Patient
Abstract Inhaled therapy is the cornerstone of asthma management in that it optimizes the delivery of the medication to the site of action. The effectiveness of inhaled therapy is affected by the correct choice of the device and proper inhalation technique. In fact, this influences the drug delivery and distribution along the bronchial tree, including the most peripheral airways. In this context, accumulating evidence supports the contribution of small airways in asthma, and these have become an important target of treatment. In reality, the “ideal inhaler” does not exist, and not all inhalers are the same. Ad...
Source: Advances in Therapy - April 7, 2015 Category: Drugs & Pharmacology Source Type: research

Non-invasive Ventilation: A Gimmick or Does It Really Affect Outcomes?
Abstract Heart failure affects 5.1 million Americans every year and leads to over 900,000 annual emergency department (ED) visits. Of those patients, over 80 % will be admitted to the hospital. In the ED, treatment focuses on preload and afterload reduction through the use of diuretics and vasodilators. For those patients requiring oxygen, particularly those in respiratory distress, non-invasive ventilation improves symptoms by increasing ventilation, decreasing preload and afterload, decreasing work of breathing, and increasing gas exchange. Non-invasive ventilation is an effective intervention and is considered...
Source: Current Emergency and Hospital Medicine Reports - April 7, 2015 Category: Emergency Medicine Source Type: research

MUC5B expression and location in surfactant protein C mutations in children
ConclusionMUC5B may play a role in the development of fibrosis in patients with SFTPC mutations, especially in patients with BRICHOS mutations. Understanding the role of MUC5B in adult and pediatric lung diseases may lead to a better understanding of the etiology of fibrotic lung disease as well as development of novel therapies. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 7, 2015 Category: Respiratory Medicine Authors: Deborah R. Liptzin, Alan M. Watson, Elissa Murphy, Miranda E. Kroehl, Megan K. Dishop, Csaba Galambos, Christopher M. Evans, Marvin I. Schwarz, Robin R. Deterding, David A. Schwartz Tags: Original Article: Genetics Source Type: research

Factors influencing delivered mean airway pressure during nasal CPAP with the RAM cannula
ConclusionsIn our bench tests, the RAM interface connected to a ventilator in NCPAP mode failed to deliver set CPAP levels when applied using the manufacturer recommended 60–80% nares occlusion, even with closed mouth and full nasal prong insertion conditions. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 7, 2015 Category: Respiratory Medicine Authors: Jeffrey S. Gerdes, Emidio M. Sivieri, Soraya Abbasi Tags: Original Article: Other Source Type: research

Sleep disordered breathing in patients with Prader–Willi syndrome: A multicenter study
ConclusionsPatients with PWS exhibit a high prevalence of SDB. The lack of association between obesity and SDB leads to hypothesize that hypotonia and/or facial dysmorphic features may play a major role in the occurrence of SDB. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 7, 2015 Category: Respiratory Medicine Authors: Martino Pavone, Valeria Caldarelli, Sonia Khirani, Marina Colella, Adriana Ramirez, Guillaume Aubertin, Antonino Crinò, Frédéric Brioude, Frédérique Gastaud, Nicole Beydon, Michèle Boulé, Lisa Giovannini‐Chami, Renato Cutrera, Brigitte Fauroux Tags: Original Article: Sleep & Breathing Source Type: research

Drosophila melanogaster Activating Transcription Factor 4 Regulates Glycolysis During Endoplasmic Reticulum Stress
Endoplasmic reticulum (ER) stress results from an imbalance between the load of proteins entering the secretory pathway and the ability of the ER to fold and process them. The response to ER stress is mediated by a collection of signaling pathways termed the unfolded protein response, which plays important roles in development and disease. Here we show that in Drosophila melanogaster S2 cells, ER stress induces a coordinated change in the expression of genes involved in carbon metabolism. Genes encoding enzymes that carry out glycolysis were up-regulated, whereas genes encoding proteins in the tricarboxylic acid cycle and ...
Source: G3: Genes Genomes Genetics - April 7, 2015 Category: Genetics & Stem Cells Authors: Lee, J. E., Oney, M., Frizzell, K., Phadnis, N., Hollien, J. Tags: Investigations Source Type: research

Apnea Testing on Extracorporeal Membrane Oxygenation: Case Report and Literature Review
Extracorporeal membrane oxygenation (ECMO) is used to resuscitate patients with cardiovascular collapse or refractory respiratory failure. Determination of death by neurologic criteria requires the performance of an apnea test. Few data exist describing performance of an apnea test in this setting. Understanding of ECMO physiology and mechanics are critical in the efficient and proper delivery of apnea testing. (Source: Journal of Critical Care)
Source: Journal of Critical Care - April 7, 2015 Category: Intensive Care Authors: Vishank Shah, Christos Lazaridis Source Type: research

Nitric oxide is a potent inhibitor of the -type heme-copper oxidases
Heme-copper oxidases (HCuOs) are integral membrane proteins that catalyze reduction of oxygen to water as the final reaction of the respiratory chain, and conserve the energy thereby released by contributing to the proton electrochemical gradient. All HCuOs have a homologous catalytic subunit with twelve transmembrane helices containing six invariant histidines which ligate three cofactors; a high-spin heme and a copper ion (CuB) in the catalytic site, and an additional low-spin heme. The HCuO superfamily is classified into three major subfamilies denoted A-, B-, and C-type [1,2]; in addition, the bacterial NO-reductases (...
Source: FEBS Letters - April 7, 2015 Category: Biochemistry Authors: Davinia Arjona, Mårten Wikström, Pia Ädelroth Source Type: research

Growing old and gasping for air
Ambient air pollution is a major risk factor for disease burden globally. It is estimated that 3.1 million deaths worldwide and 3.1% of global disability-adjusted life years can be attributed to ambient particulate matter air pollution [1]. A variety of adverse health outcomes are associated with ambient air pollution, including respiratory and cardiovascular disease, as well as premature death [2,3]. There is also a growing body of evidence that supports a role for ambient air pollution in stroke [4], metabolic diseases [5], and adverse pregnancy outcomes [6], as well as an emerging literature on the association between a...
Source: Maturitas - April 7, 2015 Category: Primary Care Authors: Jaime Madrigano Source Type: research

Evaluation of Lung Cancer by Estimating Ferritin in Exhaled Breath Condensate
Conclusion The estimated ferritin level in EBC can serve as a non invasive and inexpensive marker for screening of lung cancer. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Hypothyroidism in MDR-TB treatment – Rare occurrence but a major concern
Conclusions Occurrence of hypothyroidism is rare in MDRTB treatment. But symptomatic hypothyroidism is a major factor influencing the patient compliance towards the treatment regimen. As the drugs in regimen are effective in disease treatment, the major hindrance in achieving good cure-rate is to prevent defaulters. Identifying hypothyroidism early helps to prevent default. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Rare initial presentation of all as pleural effusion
Publication date: Available online 7 April 2015 Source:Egyptian Journal of Chest Diseases and Tuberculosis Author(s): Ashwini Kumar Mishra , Santosh Kumar , Suresh Babu , S.K. Verma , Rajiv Garg , R.A.S. Kushwaha Leukemias rarely present as pleural effusion as the first manifestation of the disease process. Most commonly this complication is seen in solid tumors such as the lung, lymphomas, carcinomas of the breast and gastrointestinal tract. A case of 40year old male is hereby highlighted who presented with a massive pleural effusion as the initial presentation of his disease process (ALL) which is a rare phenomenon to ...
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

Total serum IgE level in COPD patients
Conclusions There was a high prevalence of elevated serum T-IgE in patients with COPD but without obvious atopy. Serum T-IgE levels were found to be associated with symptoms such as dyspnea and impairment of lung function. Recurrent exacerbation of COPD is believed to accelerate disease progression and impairment of pulmonary function. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 7, 2015 Category: Respiratory Medicine Source Type: research

The cost of acute respiratory infections in Northern India: a multi-site study
Background: Despite the high mortality and morbidity resulting from acute respiratory infections (ARI) globally, there are few data from low-income countries on costs of ARI to inform public health policy decisions We conducted a prospective survey to assess costs of ARI episodes in selected primary, secondary, and tertiary healthcare facilities in north India where no respiratory pathogen vaccine is routinely recommended. Methods: Face-to-face interviews were conducted among a purposive sample of patients with ARI from healthcare facilities. Data were collected on out-of-pocket costs of hospitalization, medical consultati...
Source: BMC Public Health - April 7, 2015 Category: Consumer Health News Authors: Samuel PeasahDebjani PurakayasthaParvaiz KoulFatima DawoodSiddhartha SahaRitvik AmarchandShobha BroorVaibhab RastogiRomana AssadKaisar KaulMarc-Alain WiddowsonRenu LalAnand Krishnan Source Type: research

Nintedanib in non-small cell lung cancer: from preclinical to approval.
Abstract Angiogenesis is a driving force of a tumor's development. Targeting this process is an attractive option, as this is a feature shared by most of the solid tumors. A lot of antiangiogenic drugs have been developed following this path, including bevacizumab, sorafenib, sunitinib, vandetanib, ramucirumab, motesanib and many others. The latest drug of this class to be approved for patients with non-small cell lung cancer (NSCLC) was nintedanib, a triple angiokinase inhibitor. This molecule targets vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF) and fibroblast growth factor (FGF...
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Caglevic C, Grassi M, Raez L, Listi A, Giallombardo M, Bustamante E, Gil-Bazo I, Rolfo C Tags: Ther Adv Respir Dis Source Type: research

Bronchoconstriction in Response to Deep Inhalation During Spirometry Testing.
PMID: 25852168 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Haynes JM Tags: Respir Care Source Type: research

Use of Accelerometry to Monitor Physical Activity in Critically Ill Subjects: A Systematic Review.
Abstract Medical management of critically ill patients often incorporates prolonged bed rest, which, in combination with the underlying illness, results in global muscle weakness and atrophy. Recent evidence has demonstrated improvements in clinical and functional outcomes when exercise and physical activity are incorporated early in the management of ICU patients. Accurate monitoring of ICU patients' physical activity is essential for proper prescription and escalation of activity levels. Accelerometry is a technique used to measure physical activity and has been validated in several ambulatory populations. Howeve...
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Verceles AC, Hager ER Tags: Respir Care Source Type: research

Effect of Weight Loss on Postural Changes in Pulmonary Function in Obese Subjects: A Longitudinal Study.
CONCLUSIONS: Although postural change in FRC is absent when the morbidly obese adopt a supine position, supine reduction in FRC can be recovered following gastroplasty-induced weight loss, despite residual mild to moderate obesity. This also shows that mild to moderate obesity may affect supine FRC more than morbid obesity. (ClinicalTrials.gov registration NCT02207192.). PMID: 25852166 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 7, 2015 Category: Respiratory Medicine Authors: Sebbane M, Kamel ME, Millot A, Jung B, Lefebvre S, Rubenovitch J, Mercier G, Eledjam JJ, Jaber S, Hayot M Tags: Respir Care Source Type: research

Pseudomonas endophytica sp. nov., isolated from stem tissue of Solanum tuberosum L. in Spain.
Abstract A bacterial strain named BSTT44T was isolated in the course of a study of endophytic bacteria occurring in stems and roots of potato growing in a soil from Salamanca, Spain. The 16S rRNA gene sequence had 99.7% identity with respect to the closest relative Pseudomonas psychrophila E-3T, and the following closest related species were Pseudomonas fragi with 99.6 % similarity, Pseudomonas deceptionensis with 99.2 % and Pseudomonas lundensis with 99.0% similarity, for which BSTT44T was classified within genus Pseudomonas. The analysis of housekeeping genes rpoB, rpoD and gyrB confirmed its phylogenetic affilia...
Source: International Journal of Systematic and Evolutionary Microbiology - April 7, 2015 Category: Microbiology Authors: Ramírez-Bahena MH, Cuesta MJ, Tejedor C, Igual JM, Fernández-Pascual M, Peix A Tags: Int J Syst Evol Microbiol Source Type: research

Pathological findings and diagnostic implications of a rhesus macaque (Macacca mulatta) model of aerosol-exposure to Burkholderia mallei (glanders).
Abstract Burkholderia mallei is a Gram-negative bacillus that causes a pneumonic disease known as glanders in equids and humans and a lymphatic infection known as farcy, primarily in equids. With the potential to infect humans by the respiratory route, aerosol exposure can result in severe, occasionally fatal, pneumonia. Today, glanders infections in humans are rare, likely due to less frequent contact with infected equids than in the past. Acutely ill humans often have nonspecific clinical signs and in order to diagnose cases, especially in scenarios of multiple cases in an unexpected setting, rapid diagnostics fo...
Source: Journal of Medical Microbiology - April 7, 2015 Category: Microbiology Authors: Yingst SL, Facemire P, Chuvala L, Norwood D, Wolcott M, Huzella L Tags: J Med Microbiol Source Type: research

Mixed-Effects Model of Epithelial-Mesenchymal Transition Reveals Rewiring of Signaling Networks.
Abstract The type II Epithelial-Mesenchymal Transition (EMT) produces airway fibrosis and remodeling, contributing to the severity of asthma and chronic obstructive pulmonary disease. While numerous studies have been done on the mechanisms of the transition itself, few studies have investigated the system effects of EMT on signaling networks. Here, we use mixed effects modeling to develop a computational model of phospho-protein signaling data that compares human small airway epithelial cells (hSAECs) with their EMT-transformed counterparts across a series of perturbations with 8 ligands and 5 inhibitors, revealing...
Source: Cellular Signalling - April 7, 2015 Category: Cytology Authors: Desai P, Yang J, Tian B, Sun H, Kalita M, Ju H, Paulucci-Holthauzen A, Zhao Y, Brasier AR, Sadygov RG Tags: Cell Signal Source Type: research

Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis
Conclusions: In CLP-Only mice, although the deregulation of parameters indicative of organ injury/dysfunction was greater in dying versus surviving mice, it never exceeded the changes in surviving CLP-ODam animals, and it was not followed by histopathological damage and/or mitochondrial dysfunction. This shows that interpretation of the contribution of the organ injury/dysfunction to early deaths in the CLP model is not straightforward and depends on the pathophysiological origin of the profiled disturbances. (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - April 7, 2015 Category: Surgery Authors: Susanne DrechslerKatrin WeixelbaumerAdelheid WeidingerPierre RaevenAnna KhademHeinz RedlMartijn van GriensvenSoheyl BahramiDaniel RemickAndrey KozlovMarcin Osuchowski Source Type: research

Regional lung tissue changes with mechanical ventilation and fluid load
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Mold allergens in respiratory allergy: from structure to therapy.
Authors: Twaroch TE, Curin M, Valenta R, Swoboda I Abstract Allergic reactions to fungi were described 300 years ago, but the importance of allergy to fungi has been underestimated for a long time. Allergens from fungi mainly cause respiratory and skin symptoms in sensitized patients. In this review, we will focus on fungi and fungal allergens involved in respiratory forms of allergy, such as allergic rhinitis and asthma. Fungi can act as indoor and outdoor respiratory allergen sources, and depending on climate conditions, the rates of sensitization in individuals attending allergy clinics range from 5% to 20%. Due...
Source: Allergy, Asthma and Immunology Research - April 6, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Pulmonary edema measured by MRI correlates with late-phase response to allergen challenge
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Age influences inflammatory responses, hemodynamics, and cardiac proteasome activation during acute lung injury
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Neuron-derived orphan receptor 1 promoted human pulmonary artery smooth muscle cells proliferation
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Attenuation of lipopolysaccharide-induced acute lung injury after (pro)renin receptor blockade
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Amelioration of bleomycin-induced pulmonary fibrosis in a mouse model by a combination therapy of bosentan and imatinib
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Preemptive scalp infiltration with 0.5 % ropivacaine and 1 % lidocaine reduces postoperative pain after craniotomy
Conclusions Preemptive scalp infiltration with 0.5 % ropivacaine and 1 % lidocaine provides effective postoperative analgesia after craniotomy. (Source: Acta Neurochirurgica)
Source: Acta Neurochirurgica - April 6, 2015 Category: Neurosurgery Source Type: research

PCA-derived respiratory motion surrogates from X-ray angiograms for percutaneous coronary interventions
Conclusions we developed and evaluated a method in extraction of respiratory motion surrogate from interventional X-ray images that is easy to implement and runs in real time and thus allows extracting respiratory motion surrogates during interventions. (Source: International Journal of Computer Assisted Radiology and Surgery)
Source: International Journal of Computer Assisted Radiology and Surgery - April 6, 2015 Category: Intensive Care Source Type: research

Physical functional capacity in idiopathic pulmonary fibrosis: performance characteristics of the continuous-scale physical function performance test
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - April 6, 2015 Category: Respiratory Medicine Tags: article Source Type: research