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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

The sodium-phosphate co-transporter SLC34A2, and Pulmonary alveolar microlithiasis: presentation of an inbred family and a novel truncating mutation in exon 3
We describe, for the first time, a novel loss of function mutation in the gene coding for NaPi-IIb. A careful description of the clinical phenotype is provided together with technical details for direct sequencing of the gene. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - August 14, 2015 Category: Respiratory Medicine Source Type: research

Rasmussen’s Aneurysm: A forgotten scourge
We present a case of a young woman who presented with low-grade fever and hemoptysis. Computed tomographic (CT) angiography showed biapical cavitary lesions and actively bleeding aneurysms involving pulmonary artery, which successfully underwent glue embolization. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - August 14, 2015 Category: Respiratory Medicine Source Type: research

Cuba's complex respiratory picture
Publication date: Available online 13 August 2015 Source:The Lancet Respiratory Medicine Author(s): Conner Gorry (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - August 14, 2015 Category: Respiratory Medicine Source Type: research

World Trade Center dust-inhalation: assessing the fallout
Publication date: Available online 13 August 2015 Source:The Lancet Respiratory Medicine Author(s): Bryant Furlow (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - August 14, 2015 Category: Respiratory Medicine Source Type: research

Breathe Umphefulmo
Publication date: Available online 13 August 2015 Source:The Lancet Respiratory Medicine Author(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - August 14, 2015 Category: Respiratory Medicine Source Type: research

A nationwide analysis of the use and outcomes of perioperative epidural analgesia in patients undergoing hepatic and pancreatic surgery
Conclusions EA use among patients undergoing hepatopancreatic procedures remains low. After controlling for confounding factors, EA remained associated with a reduction in specific pulmonary-related complications, as well as in-hospital mortality. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - August 14, 2015 Category: Surgery Source Type: research

The Impact of Coagulopathy on Traumatic Splenic Injuries
Conclusion Pre-injury coagulopathy in patients with splenic injury has a negative impact on cardiac arrest, sepsis, acute respiratory distress syndrome, acute renal failure, and mortality. The higher likelihood of myocardial infarction did not reach statistical significance. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - August 14, 2015 Category: Surgery Source Type: research

Kinetic Mechanism of Na+-NQR [Bioenergetics]
The sodium-dependent NADH dehydrogenase (Na+-NQR) is the main ion transporter in Vibrio cholerae. Its activity is linked to the operation of the respiratory chain and is essential for the development of the pathogenic phenotype. Previous studies have described different aspects of the enzyme, including the electron transfer pathways, sodium pumping structures, cofactor and subunit composition, among others. However, the mechanism of the enzyme remains to be completely elucidated. In this work, we have studied the kinetic mechanism of Na+-NQR with the use of steady state kinetics and stopped flow analysis. Na+-NQR follows a...
Source: Journal of Biological Chemistry - August 14, 2015 Category: Chemistry Authors: Tuz, K., Mezic, K. G., Xu, T., Barquera, B., Juarez, O. Tags: Enzymology Source Type: research

Understanding the Kinetic Mechanism of Vibrio cholerae's Sodium-dependent NADH Dehydrogenase♦ [Papers of the Week]
♦ See referenced article, J. Biol. Chem. 2015, 290, 20009–20021Vibrio cholerae and a number of other pathogenic bacteria rely on a sodium-dependent NADH dehydrogenase (Na+-NQR). Na+-NQR is the first enzyme in the respiratory chain, and its activity appears to be important for drug elimination and virulence factor secretion. However, its mechanism of action is unclear. In this Paper of the Week, Oscar Juárez at the Illinois Institute of Technology and colleagues described how the enzyme works. They showed that the enzyme first uses NADH as a substrate. When oxidized, NAD leaves the catalytic site, and the enzyme's conf...
Source: Journal of Biological Chemistry - August 14, 2015 Category: Chemistry Tags: Enzymology Source Type: research

Modified chemically defined medium for enhanced respiratory growth of Lactobacillus casei and Lactobacillus plantarum groups
ConclusionsThe nutritional requirements of anaerobic and respiratory cultures of members of the Lact. casei and Lact. plantarum groups differ. Tween 80 and selected amino acids derived from pathways related to TCA cycle, pyruvate conversion and NADH recycling are required for respiration. Significance and Impact of the StudyThe availability of mCDM will facilitate the study of aerobic metabolism of lactobacilli under controlled conditions. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - August 14, 2015 Category: Microbiology Authors: A. Ricciardi, R.G. Ianniello, E. Parente, T. Zotta Tags: Original Article Source Type: research

Advances in the study of transmissible respiratory tumours in small ruminants
Publication date: Available online 12 August 2015 Source:Veterinary Microbiology Author(s): M. Monot, F. Archer, M. Gomes, J.-F. Mornex, C. Leroux Sheep and goats are widely infected by oncogenic retroviruses, namely Jaagsiekte Sheep RetroVirus (JSRV) and Enzootic Nasal Tumour Virus (ENTV). Under field conditions, these viruses induce transformation of differentiated epithelial cells in the lungs for Jaagsiekte Sheep RetroVirus or the nasal cavities for Enzootic Nasal Tumour Virus. As in other vertebrates, a family of endogenous retroviruses named endogenous Jaagsiekte Sheep RetroVirus (enJSRV) and closely related t...
Source: Veterinary Microbiology - August 14, 2015 Category: Veterinary Research Source Type: research

Comparison of Video Laryngoscopy Versus Direct Laryngoscopy During Urgent Endotracheal Intubation, Trial of the Route of Early Nutritional Support in Critically Ill Adults, and Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients with Severe Trauma.
PMID: 26275119 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 14, 2015 Category: Respiratory Medicine Authors: Singh A, Rali P, Arshad H, Lamba T Tags: Am J Respir Crit Care Med Source Type: research

Close Surveillance with Long-term Follow-up of Subjects with Pre-invasive Endobronchial Lesions.
CONCLUSIONS Presence of pre-invasive lesions, especially high-grade lesions, may serve as LC risk marker. LCs occur both at pre-invasive lesion sites and elsewhere in the bronchial epithelium or lung parenchyma. Prospective validation of biomarkers and randomized intervention studies are required to determine optimal management strategies. PMID: 26275031 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 14, 2015 Category: Respiratory Medicine Authors: van Boerdonk RA, Smesseim I, Heideman DA, Coupé VM, Tio D, Grünberg K, Thunnissen E, Snijders PJ, Postmus PE, Smit EF, Daniels JM, Sutedja TG Tags: Am J Respir Crit Care Med Source Type: research

Flow Cytometry Reveals Similarities Between Lung Macrophages in Humans and Mice.
Abstract Findings in murine models implicate subpopulations of alveolar macrophages in the pathogenesis of lung injury and fibrosis, however, the relevance of these findings for humans with chronic lung disease is unknown in part due to a lack of proper tools to identify macrophage heterogeneity in the human lung. Here we report a flow cytometry protocol that allows unambiguous identification of alveolar macrophages, interstitial macrophages and monocytes in the human lung and in bronchoalveolar lavage fluid. We validated this panel using normal lung tissue and tissue from patients with COPD and lung fibrosis. We f...
Source: Am J Respir Cell Mol... - August 14, 2015 Category: Respiratory Medicine Authors: Bharat A, Bhorade SM, Morales-Nebreda L, Mc Quattie-Pimentel AC, Soberanes S, Ridge K, DeCamp MM, Mestan KK, Perlman H, Budinger GR, Misharin AV Tags: Am J Respir Cell Mol Biol Source Type: research

Characterization of Distinct Macrophage Subpopulations During Nitrogen Mustard-Induced Injury and Fibrosis.
Abstract Nitrogen mustard (NM) is an alkylating agent known to cause extensive pulmonary injury progressing to fibrosis. This is accompanied by a persistent macrophage inflammatory response. In these studies we characterized the phenotype of macrophages accumulating in the lung over time following NM exposure. Treatment of rats with NM (0.125 mg/kg, i.t.) resulted in an increase in CD11b+ macrophages in histologic sections. These cells consisted of iNOS+ proinflammatory M1 macrophages, and CD68+, CD163+, CD206+, YM-1+ and ARG-II+ antiinflammatory M2 macrophages. Whereas M1 macrophages were prominent 1-3 d post NM, ...
Source: Am J Respir Cell Mol... - August 14, 2015 Category: Respiratory Medicine Authors: Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL Tags: Am J Respir Cell Mol Biol Source Type: research

Cigarette Smoke Exposure Increases Myeloid Cell Production and Lung Bacterial Clearance in Mice.
Abstract Pneumonia is a leading cause of hospitalization in patients with chronic obstructive pulmonary disease (COPD). Although most COPD patients are smokers, the effects of cigarette smoke exposure on clearance of lung bacterial pathogens and on immune and inflammatory responses are incompletely defined. Here, clearance of Streptococcus pneumoniae and Pseudomonas aeruginosa and associated immune responses were examined in mice exposed to cigarette smoke or following smoking cessation. Mice exposed to cigarette smoke for 6 weeks or 4 months demonstrated decreased lung bacterial burden compared to air-exposed mice...
Source: Am J Respir Cell Mol... - August 14, 2015 Category: Respiratory Medicine Authors: Basilico P, Cremona TP, Oevermann A, Piersigilli A, Benarafa C Tags: Am J Respir Cell Mol Biol Source Type: research

Impaired CXCR1-dependent oxidative defence in active tuberculosis patients
Much of the pronounced host inflammatory response that occurs in tuberculosis (TB) is related to failed immunity against the invading pathogen. The G-protein coupled receptors CXCR1 and CXCR2 are implicated in important signal transduction pathways in lung inflammatory responses. We investigated the expression and function of these receptors in a simple whole blood model from 24 patients with pulmonary TB and in subjects with latent TB infection (LTBI). Healthy controls were recruited from close contacts to the pulmonary index patients. (Source: Tuberculosis)
Source: Tuberculosis - August 14, 2015 Category: Respiratory Medicine Authors: Nader Alaridah, Niclas Winqvist, Gisela Håkansson, Erik Tenland, Anna Rönnholm, Erik Sturegård, Per Björkman, Gabriela Godaly Tags: Immunological Aspects Source Type: research

Efficacy of a New Intravenous β-adrenergic Agonist (Bedoradrine, MN-221) for Patients with an Acute Exacerbation of Asthma
Many patients with acute exacerbation of asthma are non-responders to inhaled β-adrenergic agonists. The goal of this study was to evaluate the safety and efficacy of intravenous bedoradrine (MN-221), a highly selective β2-adrenergic agonist, as adjunct to standard therapy in the management of patients with acute exacerbation of asthma who did not respond to standard therapy. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 14, 2015 Category: Respiratory Medicine Authors: Stacey L. House, Kazuko Matsuda, Geoffrey O’Brien, Malath Makhay, Yuichi Iwaki, Ian Ferguson, Luis M. Lovato, Lawrence M. Lewis Tags: Clinical Trial Paper Source Type: research

Estimating body composition from skinfold thicknesses and bioelectrical impedance analysis in cystic fibrosis patients
The accuracy of body composition estimates based on skinfold thickness measurements and bioelectrical impedance analysis (BIA) is not yet adequately explored in cystic fibrosis (CF). Using DXA as reference method we verified the accuracy of these techniques and identified predictors of body composition specific for CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - August 14, 2015 Category: Respiratory Medicine Authors: Gianfranco Alicandro, Alberto Battezzati, Maria Luisa Bianchi, Silvana Loi, Chiara Speziali, Arianna Bisogno, Carla Colombo Tags: Original Article Source Type: research

Tigecycline-induced acute pancreatitis in a cystic fibrosis patient: A case report and literature review
The purpose of this case report is to increase awareness of tigecycline-associated pancreatitis, specifically in patients who may be predisposed to develop pancreatitis. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - August 14, 2015 Category: Respiratory Medicine Authors: Michael T. Hemphill, Kellie R. Jones Tags: Original Article Source Type: research

Use and Interpretation of a Rapid Respiratory Syncytial Virus Antigen Detection Test Among Infants Hospitalized in a Neonatal Intensive Care Unit - Wisconsin, March 2015.
Abstract On March 25, 2015, the Wisconsin Division of Public Health was notified of a possible respiratory syncytial virus (RSV) infection outbreak among infants hospitalized in a neonatal intensive care unit (NICU). On March 23, the index patient (neonate A), aged 3 days, had feeding intolerance and apnea. A nasopharyngeal swab specimen collected from neonate A was tested using a single-manufacturer rapid RSV antigen detection test (RRADT) at the hospital laboratory; the result was positive. The following day, because of concern about the possibility of more widespread RSV infection, RRADT was used to test nasopha...
Source: MMWR Morb Mortal Wkl... - August 14, 2015 Category: Epidemiology Authors: Elbadawi LI, Haupt T, Reisdorf E, Danz T, Davis JP Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Dynamics of Enhanced Mitochondrial Respiration in Female Compared with Male Rat Cerebral Arteries.
CONCLUSIONS: Our findings show that substantial sex-differences in mitochondrial respiratory dynamics exist in large cerebral arteries and may provide the mechanistic basis for observations that the female cerebral vasculature is more adaptable after injury. PMID: 26276815 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Heart and Circulatory Physiology)
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 14, 2015 Category: Physiology Authors: Rutkai I, Dutta S, Katakam PV, Busija DW Tags: Am J Physiol Heart Circ Physiol Source Type: research

Myroides indicus sp. nov. isolated from garden soil.
Abstract A novel aerobic, non-motile, rod shaped, catalase and oxidase positive bacterial strain designated UKS3T, was isolated from garden soil, and subjected to polyphasic taxonomic analysis. Stain UKS3T formed whitish, viscous colonies on nutrient agar and was Gram-staining negative. Phylogenetic analysis, based on 16S rRNA gene sequence showed its maximum pairwise similarity occurs with representatives of the genus Myroides. The closest related species include Myroides marinus JS-08T (92.7 %), Myroides phaeus MY15T (92.7 %), Myroides odoratus DSM2801T (91.5 %) and Myroides odoratimimus CCUG 39352T (91.4 %), res...
Source: International Journal of Systematic and Evolutionary Microbiology - August 14, 2015 Category: Microbiology Authors: Ram H, Kumar A, Thomas L, Dastager SG, Mawlankar R, Singh VP Tags: Int J Syst Evol Microbiol Source Type: research

Lutibacter holmesii sp. nov., a novel marine bacterium of the family Flavobacteriaceae isolated from the sea urchin Strongylocentrotus intermedius and emended description of the genus Lutibacter.
Abstract Seven Gram-negative, strictly aerobic, pale yellow-pigmented, rod-shaped and non-motile strains were isolated from the sea urchin Strongylocentrotus intermedius collected from Troitsa Bay, Sea of Japan. Phylogenetic analyses based on 16S rRNA gene sequences showed that these isolates were affiliated with the family Flavobacteriaceae. The novel isolates indicated 99.9-100% 16S rRNA gene sequence similarity to each other and were closely related to the type strains of the recognized members of the genus Lutibacter with sequence similarities of 95.8-98.4%. The G + C content of the genomic DNA was 35-36 mol%. ...
Source: International Journal of Systematic and Evolutionary Microbiology - August 14, 2015 Category: Microbiology Authors: Nedashkovskaya OI, Van Trappen S, Zhukova NV, De Vos P Tags: Int J Syst Evol Microbiol Source Type: research

Intraspinal pressure and spinal cord perfusion pressure after spinal cord injury: an observational study.
CONCLUSIONS This preliminary observational study confirms morphological and spectral similarities between ISP in TSCI and ICP. Therefore, the known methods used for ICP waveform analysis could be transferred to ISP analysis and, upon verification, potentially used for monitoring TSCI patients. PMID: 26273764 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery.Spine)
Source: Journal of Neurosurgery.Spine - August 14, 2015 Category: Neurosurgery Authors: Varsos GV, Werndle MC, Czosnyka ZH, Smielewski P, Kolias AG, Phang I, Saadoun S, Bell BA, Zoumprouli A, Papadopoulos MC, Czosnyka M Tags: J Neurosurg Spine Source Type: research

Leptin Enhances ICAM-1 Expression, Induces Migration and Cytokine Synthesis, and Prolongs Survival of Human Airway Epithelial Cells.
Abstract There is rising interest in how obesity affects respiratory diseases, since epidemiological findings indicate a strong relationship between the two conditions. Leptin is a potent adipokine produced mainly by adipocytes. It regulates energy storage and expenditure and also induces inflammation. Previous studies have shown that leptin is able to activate inflammatory cells such as lymphocytes and granulocytes, but little is known about its effect on lung structural cells. The present study investigated the effects of leptin on human airway epithelial cells by using human primary airway epithelial cells and a...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 14, 2015 Category: Cytology Authors: Suzukawa M, Koketsu R, Baba S, Igarashi S, Nagase H, Yamaguchi M, Matsutani N, Kawamura M, Shoji S, Hebisawa A, Ohta K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Kinetic Mechanism of Na+-NQR [Bioenergetics]
The sodium-dependent NADH dehydrogenase (Na+-NQR) is the main ion transporter in Vibrio cholerae. Its activity is linked to the operation of the respiratory chain and is essential for the development of the pathogenic phenotype. Previous studies have described different aspects of the enzyme, including the electron transfer pathways, sodium pumping structures, cofactor and subunit composition, among others. However, the mechanism of the enzyme remains to be completely elucidated. In this work, we have studied the kinetic mechanism of Na+-NQR with the use of steady state kinetics and stopped flow analysis. Na+-NQR follows a...
Source: Journal of Biological Chemistry - August 14, 2015 Category: Chemistry Authors: Tuz, K., Mezic, K. G., Xu, T., Barquera, B., Juarez, O. Tags: Enzymology Source Type: research

Understanding the Kinetic Mechanism of Vibrio cholerae's Sodium-dependent NADH Dehydrogenase♦ [Papers of the Week]
♦ See referenced article, J. Biol. Chem. 2015, 290, 20009–20021Vibrio cholerae and a number of other pathogenic bacteria rely on a sodium-dependent NADH dehydrogenase (Na+-NQR). Na+-NQR is the first enzyme in the respiratory chain, and its activity appears to be important for drug elimination and virulence factor secretion. However, its mechanism of action is unclear. In this Paper of the Week, Oscar Juárez at the Illinois Institute of Technology and colleagues described how the enzyme works. They showed that the enzyme first uses NADH as a substrate. When oxidized, NAD leaves the catalytic site, and the enzyme's conf...
Source: Journal of Biological Chemistry - August 14, 2015 Category: Chemistry Tags: Enzymology Source Type: research

Polymorphism in COMT is associated with IgG 3 subclass level and susceptibility to infection in patients with chronic fatigue syndrome
Conclusion: Our results indicate a relationship of COMT polymorphism rs4680 with immune dysregulation in CFS providing a potential link for the association between stress and infection susceptibility in CFS. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - August 14, 2015 Category: Research Authors: Madlen LöbelAgnes MooslechnerSandra BauerSabrina GüntherAnne LetschLeif HanitschPatricia GrabowskiChristian MeiselHans-Dieter VolkCarmen Scheibenbogen Source Type: research

Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy.
CONCLUSION: Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However, clinical validation of this marker is necessary. PMID: 26290638 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - August 14, 2015 Category: Gastroenterology Authors: Berkelmans GH, Kouwenhoven EA, Smeets BJ, Weijs TJ, Silva Corten LC, van Det MJ, Nieuwenhuijzen GA, Luyer MD Tags: World J Gastroenterol Source Type: research

Invasive Fusobacterium necrophorum infections and Lemièrre’s syndrome: the role of thrombophilia and EBV
This study confirms earlier studies of the clinical spectrum caused by F. necrophorum. For Lemièrre’s syndrome, the study adds to the knowledge on thromboembolic outcome, demonstrating that jugular vein thrombosis may cause severe complications. The time to treatment seems to be important for the risk of severe disease. In this study, concomitant EBV infection or underlying thrombophilia was uncommon. (Source: European Journal of Clinical Microbiology and Infectious Diseases)
Source: European Journal of Clinical Microbiology and Infectious Diseases - August 13, 2015 Category: Microbiology Source Type: research

Ventilatory responses to prolonged exercise with heavy load carriage
Conclusions The mechanical disadvantage placed on the respiratory system during exercise with a heavy pack led to compensatory changes in breathing pattern and EILV, and a reduction in maximal inspiratory pressure post-exercise. We suggest that in an attempt to minimize the work of breathing, subjects adopted a shallow and frequent breathing pattern. However, this pattern increased deadspace and minute ventilation, which likely contributed to altered perceptions of exercise stress and breathing discomfort. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - August 13, 2015 Category: Physiology Source Type: research

Essential oil of Artemisia vestita exhibits potent in vitro and in vivo antibacterial activity: Investigation of the effect of oil on biofilm formation, leakage of potassium ions and survival curve measurement.
In conclusion, the in vitro and in vivo results suggested that the essential oil of A. vestita and one of its major constituents, grandisol, can significantly inhibit the growth of different bacterial strains. PMID: 26259564 [PubMed - as supplied by publisher] (Source: Molecular Medicine Reports)
Source: Molecular Medicine Reports - August 13, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lower respiratory tract disorder hospitalizations among children born via elective early-term delivery
The Journal of Maternal-Fetal & Neonatal Medicine, Ahead of Print. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - August 13, 2015 Category: Perinatology & Neonatology Tags: article Source Type: research

Novel Human-like Influenza A Viruses Circulate in Swine in Mexico and Chile
Discussion Through new surveillance efforts and phylogenetic analysis of IAV-S in Mexico and Chile, we have expanded our understanding of the extensive IAV-S diversity that circulates in swine in Latin America. Most notably, we have identified multiple novel clades of H3N2 and H1N1 viruses of human origin in Mexico and Chile that have not been identified in swine previously, highlighting the importance of the human-swine interface in the evolution of IAV-S diversity in Latin America. The presence of two different IAV-S lineages in Mexico that are related to North American IAV-S (classical H1N1 and H3-cluster IV) also demon...
Source: PLOS Currents Outbreaks - August 13, 2015 Category: Epidemiology Authors: minelson22 Source Type: research

An Outbreak of Middle East Respiratory Syndrome Coronavirus Infection in South Korea, 2015.
PMID: 26256957 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 13, 2015 Category: Universities & Medical Training Authors: Choi JY Tags: Yonsei Med J Source Type: research

Pharmacodynamic Estimate of Propofol-Induced Sedation and Airway Obstruction Effects in Obstructive Sleep Apnea-Hypopnea Syndrome.
CONCLUSION: The probability of each sedation and airway obstruction score was properly described using a sigmoid Emax model with a narrow therapeutic range of propofol Ce in OSAHS patients. Patients with high AHI values need close monitoring to ensure that airway patency is maintained during propofol sedation. PMID: 26256988 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 13, 2015 Category: Universities & Medical Training Authors: Koo BN, Shin S, Kim SY, Kang YR, Jeong KH, Han DW Tags: Yonsei Med J Source Type: research

Effects of Alveolar Recruitment and Positive End-Expiratory Pressure on Oxygenation during One-Lung Ventilation in the Supine Position.
CONCLUSION: Recruitment of both lungs with subsequent PEEP before OLV improved arterial oxygenation and ventilatory efficiency during video-assisted thoracic surgery requiring OLV in the supine position. PMID: 26256990 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 13, 2015 Category: Universities & Medical Training Authors: Choi YS, Bae MK, Kim SH, Park JE, Kim SY, Oh YJ Tags: Yonsei Med J Source Type: research

Invasive Primary Colonic Aspergillosis in the Immunocompetent Host without Classical Risk Factors.
We describe a very rare case of IA involving the lower GI tract in the patient without classical risk factors that presented as multiple colon perforations and was successfully treated by surgery and antifungal treatment. We also review related literature and discuss the characteristics and risk factors of IA in the immunocompetent hosts without classical risk factors. This case that shows IA should be considered in critically ill patients, and that primary lower GI aspergillosis may also occur in the immunocompetent hosts without classical risk factors. PMID: 26256995 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - August 13, 2015 Category: Universities & Medical Training Authors: Cha SA, Kim MH, Lim TS, Kim HH, Chang KY, Park HS, Kim HW, Wie SH, Jin DC Tags: Yonsei Med J Source Type: research

Antiplatelet therapy in Takotsubo cardiomyopathy: does it improve cardiovascular outcomes during index event?
Abstract Plasma catecholamines may play an important role in Takotsubo cardiomyopathy (TCM) pathophysiology. Patients with disproportionately high catecholamine responses to stressful events are prone to worse clinical outcomes. Catecholamines stimulate platelet activation and, therefore, may determine the clinical presentation and outcomes of TCM. We conducted a retrospective, descriptive study TCM patients admitted between 2003 and 2013 to Einstein Medical Center, Philadelphia, PA, USA and Danbury Hospital, Danbury, CT, USA. A total of 206 patients met Modified Mayo TCM criteria. Using a multiple logistic model,...
Source: Heart and Vessels - August 13, 2015 Category: Cardiology Source Type: research

Fatal co-infection with leptospirosis and dengue in a Sri Lankan male
Conclusion: In areas where both leptospirosis and dengue are endemic, both infections should be include in the differential diagnosis when evaluating patients with acute febrile illness and should consider the possibility of co-infection. Leptospirosis, being a condition having definitive antibiotic therapy, should always be ruled out even if the patient is positive for dengue serology in regions endemic to both these diseases as early initiation of antibiotic therapy can reduce mortality significantly. (Source: BMC Research Notes)
Source: BMC Research Notes - August 13, 2015 Category: Research Authors: Aruna WijesingheNanthini GnanapragashGayan RanasingheMurugapillai Ragunathan Source Type: research

Long-Term Survival After Lung Transplantation in Patients with Silicosis and Other Occupational Lung Disease
Conclusion Long-term survival for adult patients with silicosis and non-silicotic OLD after LTx is not significantly different compared to the general lung transplant population. (Source: Lung)
Source: Lung - August 13, 2015 Category: Respiratory Medicine Source Type: research