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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Adrenomedullin optimizes mortality prediction in COPD
This study is a pooled analysis of 1285 patients from the COMIC and PROMISE-COPD studies. Patients were categorized into low and high risk based on proADM level (<0.87 or ≥ 0.87nmol/L), ADO (< 6 or ≥ 6), updated ADO (<10 or ≥ 10) and BOD index (<4 or ≥ 4). Furthermore, combinations of risks based on the indices and proADM (low/low, low/high, high/low and high/high) were made, which resulted in the ADOA, ADOAupdated and BODA index.Patients with high proADM levels had a 2.1 fold (p<0.001) higher risk of dying than those with lower levels. Based on the C-statistic, solely proADM (C=0.77) was the mos...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Brusse-Keizer, M., Zuur-Telgen, M., van der Palen, J., vanderValk, P., Kerstjens, H., Boerrsma, W., Blasi, F., Kostikas, K., Milenkovic, B., Tamm, M., Stolz, D. Tags: 1.12 Clinical Problems - COPD Source Type: research

Characterising patterns of prescribing for UK COPD patients with comorbidities or history of pneumonia
Conclusion: ICSs and their combinations are prescribed frequently for COPD patients with diabetes, osteoporosis and history of pneumonia, who might be more at risk of ICS side effects, while bronchodilator monotherapy is prescribed frequently for COPD patients with asthma who might benefit from added ICS. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Price, D., Bichel, K., West, D., Carter, V., Ashton, V. L., Stewart, R. Tags: 1.12 Clinical Problems - COPD Source Type: research

COPD patients may suffer from frequent exacerbations but mostly do not - Subpopulations of a real life survey in more than 1.700 patients
Discussion: The data in this population fail to show exacerbations as one of the major problems in treating COPD.We must learn to differentiate what to treat . Improving dyspnea, cough and lung function are major goals but less discussed. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Klopf, D., Rumpf, J., Maier-Stocker, P., Koehl, C., Thomas, K., Pfeuffer, H.-P., Berg, P., Sommer, C. Tags: 1.12 Clinical Problems - COPD Source Type: research

Are re-admissions with acute exacerbation of chronic obstructive pulmonary disease coded correctly?
Conclusion: Almost 50% of patients coded as re-admissions with acute exacerbation of COPD were inaccurate. Clinical coding needs to improve in order to minimise and avoid financial penalties. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Ahmed, M., Rickard, B., Lynch, C., Owen, G., Bradbury, S., Leech, K., Allen, M. Tags: 1.12 Clinical Problems - COPD Source Type: research

Integrated care reduces hospital utilization among patients with severe COPD
Conclusion: The COPD-Home ICM reduced hospital utilization in patients with COPD III and IV with a persisting effect throughout the 2 year follow-up period. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Titova, E., Sunde, S., Steishamn, S., Henriksen, A. H. Tags: 1.12 Clinical Problems - COPD Source Type: research

The value of the body composition analysis on COPD patients in different groups according to BMI
Conclusions: Results show that the most interesting was group with a normal BMI, where we found 49 % of patients with low FFMI. In this group of patients may be normal BMI misinterpreted and, therefore, may be mistaken for patients with normal body composition. Therefore, this group of COPD patients could be left out of rehabilitation programs and nutritional and therapeutic interventions. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Marget, I., Bajcar, L., Magula, D., Cerna, L., Rozborilova, E. Tags: 1.12 Clinical Problems - COPD Source Type: research

The relationship between 24-hour symptoms and COPD exacerbations: Results from ASSESS
ConclusionAround the clock COPD symptoms were associated with more exacerbations. Most patients, irrespective of exacerbation history, had night-time and morning symptoms. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Miravitlles, M., Worth, H., Soler Cataluna, J. J., Price, D., De Benedetto, F., Roche, N., Godtfredsen, N. S., van der Molen, T., Lofdahl, C.-G., Padulles, L., Ribera, A. Tags: 1.12 Clinical Problems - COPD Source Type: research

Endobronchial ultrasound in study of airway wall remodeling in COPD patients
CONCLUSIONSThe significant differences in bronchial wall layers thickness in COPD and severe asthma and no correlation between bronchial wall layers and pulmonary function tests observed only in COPD patients suggest different mechanism responsible for remodeling and bronchial obstruction in this disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Soja, J., Loboda, P., Mikrut, S., Cmiel, A., Gross-Sondej, I., Kasper, L., Andrychiewicz, A., Gorka, K., Pulka, G., Sladek, K. Tags: 1.12 Clinical Problems - COPD Source Type: research

The BODE index predicts mortality better than 2007 GOLD and GOLD ABCD
Chronic Obstructive Pulmonary Disease (COPD) has a high mortality. Many indices have been developed to classify disease severity including the 2007 and 2011 GOLD classification and BODE index. However, no study has compared the prediction of mortality by those indices.This is an observational study of 96 patients with COPD and followed prospectively for a median of 60 months. We performed at baseline pulmonary function tests, 6-minute walking test, dyspnea scale mMRC, anthropometric and questionnaire measures of exacerbations. BODE index and GOLD 2007 and GOLD 2011 classification was calculated. The capacity of all indices...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Berto Botella, J., Pinto-Plata, V., Divo, M., Marin, J. M., Celli, B., Casanova, C., Cabrera, C., Zagaceta, J., Sanchez-Salcedo, P., Lopez-Zalduendo, E., Zulueta, J., Juan Pablo, J. P., Celli, B. Tags: 1.12 Clinical Problems - COPD Source Type: research

Pulse wave velocity in patients with COPD comorbid with arterial hypertension
To evaluate the performance of arterial stiffness in patients with COPD and arterial hypertension.58 patients with a mean age of 57.6±6.3 years were examined. The patients were divided into 3 groups: group 1, n=20, patients with combination of hypertension and COPD; group 2, n=20, patients with hypertension; group 3, n=18, patients with COPD. The groups were similar in for age, sex, duration of hypertension and COPD. Applanation tonometry and pulse wave velocity were made by SphygmoCor.Patients of group 1 showed the improvement of central systolic blood pressure in compassion with group 2 (131.8±4.8 mmHg vs 1...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Aksenova, T., Gorbunov, V., Tsarenok, S., Gagarkina, L. Tags: 1.12 Clinical Problems - COPD Source Type: research

Distribution and outcomes of the new Spanish phenotype-based guideline for COPD
Conclusions: There is an uneven distribution of COPD phenotypes in stable COPD patients, with significant clinical and use of health resources differences. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Cosio, B. G., Soriano, J. B., Calle, M., Soler, J. J., De Torres, J. P., Marin, J. M., Martinez, C., De Lucas, P., Mir, I., Peces-Barba, G., Feu, N., Solanes, I., Alfageme, I., Casanova, C. Tags: 1.12 Clinical Problems - COPD Source Type: research

Pharmacological treatment of COPD in the on-sint cohort
CONCLUSIONS:On-Sint cohort has detected an increase in the use of LABD and ICS,although the indication seems to be more consistent with the functional severity.Mucolytics are still excessively used.The use of all groups of treatment is lower for those with unknown GOLD stage. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Marin Barrera, L., Lopez Ramirez, C., Lopez-Campos, J. L., Calero Acuna, C., Fernandez-Villar, A., Represas Represas, C., Ramos Hernandez, C., Casamor, R. Tags: 1.12 Clinical Problems - COPD Source Type: research

Factors of cardiac dysfunction in advanced COPD
Conclusions: patients with hyperinflation (IC/TLC≤0.25) in COPD have an impaired left ventricular diastolic filling. The decreasing heart size not only is present in severe emphysema but also shows a substantial association with hyperinflation. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Porakhonko, N., Lapteva, I., Kharevich, O., Lapteva, E., Orlova, I. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Regional ventilation quantified by multi-volume computed tomography (CT): Comparison with 3-helium magnetic resonance imaging (3He-MRI)
In conclusion, CT-based and 3He-MRI ventilation imaging show a reasonable correlation in asthmatic subjects, suggesting that SVg maps can be used to identify ventilation defects. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Pennati, F., Salito, C., Quirk, J., Castro, M., Woods, J., Aliverti, A. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Tracheobronchial collapses in acute asthmatic attack
Conclusions: Patients with AAA demonstrated presences of TBCs of different severities which mostly improved with time. TBC at tracheal rings near to the carina was most prominent that influenced the changes of PEFRs. TBCs thus play roles in the falls of PEFRs during AAA. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Kiatboonsri, S., Lertpongpiroon, S., Suwatanapongched, T., Sutheerasan, Y., Theerawit, P. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Characterisation of acinar airspace involvement in patients with asthma using hyperpolarised 3He magnetic resonance and quantitative computed tomography
ConclusionAcinar airway involvement in asthma appears to be characterised by distension of the distal airspaces due to expiratory air trapping without evidence of acinar airway remodelling or emphysema. Further work evaluating histopathology of the small airways and computational modelling is required to confirm these observations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Gonem, S., Hardy, S., Buhl, N., Hartley, R., Soares, M., Kay, R., Costanza, R., Gustafsson, P., Brightling, C., Owers-Bradley, J., Siddiqui, S. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Clinical validation of a CT-based impulse oscillometry model
Conclusions: Resistance measures simulated using the model correlate with their clinical counterparts. This opens up the possibility of investigating the link between airway structure and clinical IOS resistance recordings on a patient specific basis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Bordas, R., Gonem, S., Lefevre, C., Veeckmans, B., Hartley, R., Pitt-Francis, J., Fetita, C., Brightling, C., Owers-Bradley, J., Kay, D., Siddiqui, S., Burrowes, K. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Changes in brain volume after hypoxic exposure and exercise investigated by magnetic resonance imaging
Recent data suggest that hypoxia can increase brain volume by inducing cerebral oedema. Exercise is thought to exacerbate acute mountain sickness (AMS) and possibly to enhance cerebral suboedema. The present study investigated the effect of hypoxic exposure and exercise on cerebral volume and oedema by magnetic resonance imaging. Twelve healthy males performed 3 semi-randomized 11-h sessions with i) an inspiratory O2 fraction (FiO2) of 11% and 4-h cycling, ii) FiO2=21% and 4-h cycling and iii) FiO2=8.5-11% (adjusted to match arterial O2 saturation measured during session 1) at rest. Volumetric, apparent diffusion coefficie...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Verges, S., Rupp, T., Jubeau, M., Lamalle, L., Warnking, J., Millet, G., Esteve, F., Krainik, A., Levy, P. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Changes in regional distribution of gas and blood volumes within a single respiratory cycle: Effect of tidal volume, PEEP and respiratory pattern
Conclusions: This study shows for the first time, the relation between regional blood and gas volume during the respiratory cycle. The dynamics of Vg and Vb were affected both by VT and PEEP level. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Porra, L., Wallin, M., Hallback, M., Broche, L., Suortti, P., Sovijarvi, A., Petak, F., Habre, W., Bayat, S. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Comparison of CT-based lobar ventilation models with 3He MRI ventilation measurements in asthmatics
Conclusion This study compares percentage lobar ventilation from CT models with a direct measure of gas ventilation using 3He MRI. In so doing we validate the CT ventilation model and demonstrate that multi-modal registration allows the regional interpretation of 3He MR images on top of the underlying anatomy of the CT.References [1]Radiol 2010;257:854-62 [2]NMR Biomed 2011;24:130-34. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Tahir, B., Van Holsbeke, C., Rob, I., Andy, S., Horn, F., Marshall, H., Parra-Robles, J., Hartley, R., Kay, R., Chris, B., De Backer, J., Vos, W., Wild, J. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Influence of the cardiac cycle on the airflow patterns during inhalation in healthy subjects investigated with 3He MRI
Conclusion: Cardiac pulsation is responsible for a volume change of the lung, which modulates airflow and ventilation. This effect can be quantified with lung MRI and needs to be taken into consideration when measuring and modelling regional lung ventilation in disease. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Collier, G., Marshall, H., Wild, J. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Visualising regional ventilation heterogeneity by linking multiple breath washout to 3He MRI imaging
Conclusions: This preliminary study shows that simulated washout from imaging predicts that from MBW. MBW-imaging gives novel spatial insight into washout time constants within the lung, and will play an important role in understanding ventilation heterogeneity in the context of MBW indices (e.g. LCI).References:[1]Horn et al., JAP;[116]129-39. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Horn, F., Horsley, A., Smith, L., Tayler, C., Marshall, H., Parra-Robles, J., Wild, J. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Alterations of diaphragm (DI) and rib cage (RC) morphology in severe COPD patients by CT analysis
Although it is known that in patients with COPD hyperinflation determines shortening of the inspiratory muscles, its effects on DI and RC morphology are still to be investigated. Therefore, the relationships between hyperinflation, DI and RC geometry were studied in 5 severe COPD patients (3F, 2M, age 62±6, FEV1%pred 18±4, %Low Attenuation Areas 43±10) and 5 healthy subjects (3F, 2M, age 48±4, FEV1%pred 114±20) by a custom software able to automatically obtain DI and RC 3D reconstruction from CT scans taken at TLC and RV. Dome surface area (Ado), length (Ld), radius of curvature and posit...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Salito, C., Luoni, E., Aliverti, A. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Nomenclature of broncho-pulmonary anatomy: 60 years later
ConclusionsAs non-invasive retrospective CT analysis demonstrated, BP anatomy variations are not uncommon. It might be of interest to undertake an epidemiologic study to investigate the extent of anatomic variations in the BP anatomy. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Vos, W., Volkovych, S., Van Holsbeke, C., Veeckmans, B., De Backer, J., De Backer, W. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research

Comparison between spirometry and computed tomography to evaluate dynamic hyperinflation in COPD patients
Conclusions: In the present sample, quantitative CT measurements were insensitive to detect DH in patients with moderate COPD. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Berton, D., Santos, A., Hochhegger, B., Bohn, Jr., I., Lima, R., Breda, V., Teixeira, P. Tags: 4.1 Clinical Respiratory Physiology, Exercise and Functional Imaging Source Type: research