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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Concentrated NSAID for large animals
Bayer Animal Health has extended its range of products for farm animals with the addition of Dinalgen, an injectable NSAID that is licensed for use in cattle, pigs and horses. The product contains ketoprofen, available as a 150 mg/ml solution for injection. The company claims that the more concentrated format allows the product to provide ‘the smallest dose, fast relief NSAID currently available for cattle in the UK’. In cattle, the product is licensed for the reduction of inflammation and pain associated with lameness, postpartum and musculoskeletal disorders; reduction of fever associated with bovine res...
Source: Veterinary Record - July 23, 2015 Category: Veterinary Research Tags: Products and Services Source Type: research

European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014
Enterovirus D68 (EV-D68), formerly classified as rhinovirus 87 (RV-87) [14], has a mixture of enterovirus (EV) and rhinovirus (RV) features and can induce severe respiratory symptoms, mostly in children [15,16]. In addition, it has been detected in respiratory samples from patients who developed acute flaccid paralysis (AFP) or acute flaccid myelitis [12], but no definite link between EV-D68 infection and neurological disease has yet been established [13]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 23, 2015 Category: Virology Authors: Randy Poelman, Isabelle Schuffenecker, Coretta van Leer-Buter, Laurence Josset, Hubert G.M. Niesters, Bruno Lina, on behalf of the ESCV-ECDC EV-D68 study group Source Type: research

Prostanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities.
Abstract Pathophysiologic gaps in the actions of currently available treatments for asthma and COPD include neutrophilic inflammation, airway remodeling, and alveolar destruction. All of these processes can be modulated by cyclic AMP-elevating prostaglandins E2 and I2 (also known as prostacyclin). These prostanoids have long been known to elicit bronchodilation and to protect against bronchoconstriction provoked by a variety of stimuli. Much less well known is their capacity to inhibit inflammatory responses involving activation of lymphocytes, eosinophils, and neutrophils as well as to attenuate epithelial injury ...
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Zaslona Z, Peters-Golden M Tags: Chest Source Type: research

Critical Care Transesophageal Echocardiography.
This article will review critical care TEE in reference to training, equipment, comparison to TTE, indications, safety, and standard views of critical care TEE. It should be considered a companion article to a recent two part series in CHEST that focused on advanced critical care TTE. Included with this article is an online supplement that has a representative series of critical care TEE images with clinical commentary. PMID: 26204465 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Mayo PH, Narasimhan M, Koenig S Tags: Chest Source Type: research

Pulmonary Hypertension in the setting of Hereditary Hemorrhagic Telangiectasia.
Conclusions: PH in patients with HHT occurs by different mechanisms, and there is a trend towards worse survival in patients that develop PH despite the mechanism. The equal predilection towards all subtypes of PH illustrates the necessity of RHC to clarify the hemodynamics. PMID: 26204445 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Lyle MA, Fenstad ER, McGoon MD, Frantz RP, Krowka MJ, Kane GC, Swanson KL Tags: Chest Source Type: research

A double-blind placebo-controlled study of the effects of olprinone, a specific phosphodiesterase-III inhibitor, for preventing postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer.
CONCLUSIONS: Continuous infusion of olprinone during lung cancer surgery was safe and reduced the incidence of postoperative atrial fibrillation following pulmonary resection in patients with elevated preoperative BNP levels. Trial Registration: JPRN-UMIN2404. PMID: 26204331 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Nojiri T, Yamamoto K, Maeda H, Takeuchi Y, Ose N, Susaki Y, Inoue M, Okumura M Tags: Chest Source Type: research

Association of psychological disorders with 30-day readmission rates in patients with Chronic Obstructive Pulmonary Disease.
Conclusion: Psychological disorders like depression, anxiety, psychosis, alcohol abuse and drug abuse are independently associated with higher all cause 30-day readmission rates for Medicare beneficiaries with COPD. PMID: 26204260 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Singh G, Zhang W, Kuo YF, Sharma G Tags: Chest Source Type: research

Risk stratification of patients with acute symptomatic pulmonary embolism based on presence or absence of lower extremity deep vein thrombosis: systematic review and meta-analysis.
Conclusions: In patients diagnosed with acute symptomatic PE, concomitant DVT was significantly associated with an increased risk of death within 30 days of PE diagnosis. PMID: 26204122 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Becattini C, Cohen AT, Agnelli G, Howard L, Castejón B, Trujillo-Santos J, Monreal M, Perrier A, Yusen RD, Jiménez D Tags: Chest Source Type: research

Pulseless oximetry: A preliminary evaluation.
Conclusions: Preliminary results in a small number of patients demonstrate that pulseless oximetry can be used to estimate arterial saturation with acceptable accuracy. Clinical Implications: A noninvasive oximeter that does not rely on pulsatile flow would be a valuable advance in assessing oxygenation in patients with LVADs, for whom the only current option is arterial puncture, which is painful, risks arterial injury, and only provides a snapshot evaluation of oxygenation. PMID: 26204107 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Aldrich TK, Gupta P, Stoy S, Carlese A, Goldstein DJ Tags: Chest Source Type: research

Novel Bedside Phonetic Evaluation to Identify Dysphagia and Aspiration Risk.
Conclusions: Abnormal phonation among intensive and intermediate care unit patients is associated with dysphagia and aspiration. Future investigative efforts should uncover the most effective combination of evaluations for accurate bedside detection of dysphagia and aspiration risk in a broad spectrum of patients. PMID: 26203916 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Festic E, Soto Soto J, Pitre LA, Leveton M, Ramsey DM, Freeman WD, Heckman MG, Lee AS Tags: Chest Source Type: research

Structural Brain Changes in Patients with Chronic Obstructive Pulmonary Disease.
Conclusions: COPD patients demonstrated gray matter decreases in brain areas relevant for the processing of dyspnea, fear, and antinociception. These structural brain changes were partly related to longer disease duration and greater disease-specific fears, which might contribute to a less favorable course of the disease. PMID: 26203911 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Esser RW, Stoeckel MC, Kirsten A, Watz H, Taube K, Lehmann K, Petersen S, Magnussen H, von Leupoldt A Tags: Chest Source Type: research

Validation of the IMPROVE Bleeding Risk Score.
Conclusions: The IMPROVE BRS calculated at admission predicts major bleeding in medical inpatients. This model may help assess relative risks of bleeding and VTE before chemoprophylaxis is administered. PMID: 26203792 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Hostler DC, Marx ES, Moores LK, Petteys S, Hostler JM, Mitchell JD, Holley PR, Collen JF, Foster B, Holley AB Tags: Chest Source Type: research

Interpretability of Change Scores in Measures of Balance in People with COPD.
Conclusion: Among COPD patients undergoing pulmonary rehabilitation, a change of 5 to 7 points for the BBS, 13 to 17 points for the BESTest and 19 points for the ABC scale is required to be both perceptible to patients and beyond measurement error. PMID: 26203790 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Beauchamp MK, Harrison SL, Goldstein RS, Brooks D Tags: Chest Source Type: research

Outcomes and prognostic features of patients with influenza requiring hospitalization and receiving early antiviral therapy: A Prospective Multicenter-Cohort Study.
Conclusions: Among the prognostic factors, malnutrition and pneumonia are amenable to medical intervention. There is an opportunity to improve empiric therapy for patients with HCAP and influenza. Trial registration: Japan Medical Association Center for Clinical Trials JMA-IIA00123. PMID: 26203671 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Maruyama T, Fujisawa T, Suga S, Nakamura H, Nagao M, Taniguchi K, Tsutsui K, Ihara T, Niederman MS Tags: Chest Source Type: research

Changing Epidemiology of the Respiratory Bacteriology of Patients with Cystic Fibrosis.
Conclusions: The epidemiology of CF pathogens continues to change. The causes of these observations are most likely multifactorial and include improvements in clinical care and infection prevention and control. Data from this study will be useful to evaluate the impact of new therapies on CF microbiology. PMID: 26203598 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Salsgiver EL, Fink AK, Knapp EA, LiPuma JJ, Olivier KN, Marshall BC, Saiman L Tags: Chest Source Type: research

The Utility of the Swine Model to Assess Biological Rhythms and Their Characteristics during Different Stages of Residence in a Simulated Intensive Care Unit: A Pilot Study.
Abstract The purpose of this pilot study was to explore the utility of the mammalian swine model under simulated intensive care unit (sICU) conditions and mechanical ventilation (MV) for assessment of the trajectory of circadian rhythms of sedation requirement, core body temperature (CBT), pulmonary mechanics (PM) and gas exchange (GE). Data were collected prospectively with an observational time-series design to describe and compare circadian rhythms of selected study variables in four swine mechanically ventilated for up to seven consecutive days. We derived the circadian (total variance explained by rhythms of ...
Source: Chronobiology International - July 23, 2015 Category: Biology Authors: Leyden KN, Hanneman SK, Padhye NS, Smolensky MH, Kang DH, Chow DS Tags: Chronobiol Int Source Type: research

Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm.
CONCLUSION: Drug-related pneumonitis was noted on CT in 58% of Waldenström macroglobulinemia patients treated with mTOR inhibitor therapy. Most common findings were bilateral GGOs and reticular opacities, with or without consolidation, in peripheral and lower lungs, demonstrating COP and NSIP patterns. IMPLICATIONS FOR PRACTICE: The present study has demonstrated that drug-related pneumonitis during mammalian target of rapamycin (mTOR) inhibitor therapy is highly frequent, occurring in 58% of patients with Waldenström macroglobulinemia. The radiographic patterns of pneumonitis demonstrated cryptogenic organizing pneu...
Source: The Oncologist - July 23, 2015 Category: Cancer & Oncology Authors: Nishino M, Boswell EN, Hatabu H, Ghobrial IM, Ramaiya NH Tags: Oncologist Source Type: research

All-cause mortality and use of antithrombotics within 90 days of discharge in acutely ill medical patients.
Abstract Conflicting evidence exists regarding predictors of and antithrombotic benefit on mortality in hospitalised acutely-ill medical patients. We compared mortality risk within 90 days post-discharge among medically ill patients who did and did not receive antithrombotics. This retrospective claims analysis included patients ≥ 40 years with nonsurgical hospitalisation ≥ 2 days between 2005 and 2009 using the HealthCore Integrated Research Database. Antithrombotic use (i.e. anticoagulants and antiplatelets) post-discharge was captured from pharmacy claims. All-cause mortality was determined from Social S...
Source: Thrombosis and Haemostasis - July 23, 2015 Category: Hematology Authors: Mahan CE, Fields LE, Mills RM, Stephenson JJ, Fu AC, Fisher MD, Spyropoulos AC Tags: Thromb Haemost Source Type: research

PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice.
CONCLUSIONS: PHiD-CV induced high levels of Protein D-specific antibodies, but did not augment pulmonary clearance of NTHi. We found no evidence to suggest that PHiD-CV will offer added benefit by preventing NTHi lung infection. PMID: 26212006 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 23, 2015 Category: Allergy & Immunology Authors: Siggins MK, Gill SK, Langford PR, Li Y, Ladhani SN, Tregoning JS Tags: Vaccine Source Type: research

Qipengyuania sediminis gen. nov., sp. nov., a novel member of the family Erythrobacteraceae, isolated from subterrestrial sediment.
Abstract A Gram-reaction-negative, non-motile, facultatively aerobic bacterium, designated as strain M1T, was isolated from a subterrestrial sediment sample of Qiangtang Basin in Qinghai-Tibetan plateau, China. The strain formed rough yellow colonies on R2A plates. Cells were ovals and short rods. Catalase test was positive and oxidase test was negative. Phylogenetic analyses based on 16S rRNA gene sequence indicated that the isolate belonged to the family Erythrobacteraceae and showed 96.2-96.4 % sequence similarities to the most closely relatives. Chemotaxonomic analysis revealed ubiquinone-10 (Q10) as the domina...
Source: International Journal of Systematic and Evolutionary Microbiology - July 23, 2015 Category: Microbiology Authors: Feng XM, Mo YX, Han L, Nogi Y, Zhu YH, Lv J Tags: Int J Syst Evol Microbiol Source Type: research

The role inflammatory response genes in obstructive sleep apnea syndrome: a review
Abstract Background Obstructive sleep apnea syndrome (OSAS) has a negative impact on health and behavior of millions of individuals worldwide. The pathogenesis of this disorder is a multifactorial process related to a variety of mechanisms, including selective activation of inflammatory response pathways. A number of inflammatory factors, such as IL-6, IL-8, and TNF-α, can be found in high concentrations in subjects with OSAS and may serve as biological markers of this disease. The concentration of these cytokines contributes to weight gain in patients with OSAS and can also modify the risk o...
Source: Sleep and Breathing - July 22, 2015 Category: Respiratory Medicine Source Type: research

Does Risk for Malnutrition in Patients Presenting With Fractures Predict Lower Quality Measures?
Conclusions: Patients treated for fractures and dislocations with any sign of malnutrition according to the MUST score were more than twice as likely to acquire some combination of infection, venous thromboembolism, respiratory failure, or other reason for readmission than those of normal nutritional status. Increasing levels of malnourishment corresponded with increasing risk for developing complications, whereas these complications were not necessarily associated with higher comorbidity. An assessment of a fracture patient's nutritional status should be considered a factor in evaluating risks related to fracture care. Th...
Source: Journal of Orthopaedic Trauma - July 22, 2015 Category: Orthopaedics Tags: Original Article Source Type: research

Use of Ambulatory Blood Pressure Monitoring for the Screening of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a frequent and underdiagnosed disease in hypertensive individuals who experience cardiovascular events. The aim of this study was to define the best model that combined the ambulatory blood pressure (BP) monitoring (ABPM), anthropometric, sociodemographic, and biological variables to identify moderate to severe OSA. A total of 105 ABPM‐confirmed hypertensive patients were evaluated using their clinical histories, blood analyses, ABPM, and home respiratory polygraphic results. A multivariate logistic regression analysis was performed to identify the significant variables. The best model in...
Source: The Journal of Clinical Hypertension - July 22, 2015 Category: Cardiology Authors: Gerard Torres, Manuel Sánchez‐de‐la‐Torre, Montserrat Martínez‐Alonso, Silvia Gómez, Oscar Sacristán, Jacint Cabau, Ferran Barbé Tags: Original Paper Source Type: research

Aerosol-Transmitted Infections—a New Consideration for Public Health and Infection Control Teams
This article reviews the evidence and characteristics of some of the accepted (tuberculosis, measles, chickenpox, whooping cough) and some of the more opportunistic (influenza, Clostridium difficile, norovirus) aerosol-transmitted infectious agents and outlines methods of detecting and quantifying transmission. (Source: Current Treatment Options in Infectious Diseases)
Source: Current Treatment Options in Infectious Diseases - July 22, 2015 Category: Infectious Diseases Source Type: research

Human Rhinovirus Types and Association with Respiratory Symptoms During the First Year of Life
Human rhinoviruses (HRV) cause respiratory infections and are associated with asthma development. We assessed HRV prevalence, types and association with respiratory symptoms in the first year of life in 20 unselected infants. HRV was detected in 32% of 825 weekly nasal swabs. Seventy-four different types of all three species were identified. HRV presence and related respiratory symptoms are highly heterogeneous. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Factors Affecting Staphylococcus aureus Colonization of the Nasopharynx in the First 6 Months of Life
Conclusions: SA colonization of NP begins very early in life and declines quickly. Methicillin-resistant SA has lower ability to maintain prolonged colonization status than methicillin-susceptible strains in the first 6 months of life. As the NP is colonized with other respiratory bacterial pathogens, the colonization with SA declines; however, this effect is stronger with Gram-negative bacteria, such as NTHI and MC. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

Household Food Insecurity is Associated with Respiratory Infections Among 6–11-Month Old Infants in Rural Ghana
Conclusion: Infants living in food insecure households are at an increased risk of respiratory tract morbidity. Interventions that address HHFI might be important to improve infant health in rural Ghana. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

Stress index for positive end‐expiratory pressure titration in prone position: a piglet study
ConclusionsStress index can be used to titrate PEEP in the prone position in a surfactant‐depleted lung injury model. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - July 22, 2015 Category: Anesthesiology Authors: C. Pan, R. Tang, J. Xie, J. Xu, S. Liu, T. Yu, Y. Huang, F. Guo, Y. Yang, H. Qiu Tags: Original Article Source Type: research

Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats
Inhalation Toxicology, Ahead of Print. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 22, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Trends in mortality associated with opening of a full-capacity public emergency department at the main tertiary-level hospital in Tanzania
Conclusions The opening of a full-capacity ED in a tertiary-level hospital in sub-Saharan Africa was associated with a significant decrease in hospital mortality. This is despite a small, but significant, increase in the mortality rate in the ED as compared to that in the casualty room that it replaced. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - July 22, 2015 Category: Emergency Medicine Source Type: research

A maintenance hemodialysis diabetic patient with unexplained pulmonary and gastrointestinal involvement
Abstract A 50‐year‐old man with diabetes mellitus with diabetic retinopathy, peripheral neuropathy, hypertension, and end‐stage renal disease on maintenance hemodialysis, presented with persistent cough and hiccups, continued to be unwell with weight loss, poor appetite, and recurrent respiratory symptoms such as wheezing and cough. Whole body positron emission tomography‐computed tomography scan showed metabolically active lesions in liver, stomach/lesser sac, pancreas, and left sixth rib. As he had repeated bilateral transudative pleural effusion, left mini thoracotomy with pleural biopsy showed no evidence of gr...
Source: Hemodialysis International - July 22, 2015 Category: Hematology Authors: Anand Yuvaraj, Georgi Abraham, Abraham Kurien, Priyanka Koshy, Sanjeev Nair, Sudhakshina Ghosh Tags: Case Report Source Type: research

Severe liver failure due to influenza A infection in a hemodialysis patient
We report a case of a hemodialysis patient with influenza A infection who presented with severe hepatitis and liver failure, while his respiratory symptoms were mild. It is important to recognize influenza infection as an unexplained cause of hepatitis and liver failure. In our case, liver failure resolved with supportive treatment. (Source: Hemodialysis International)
Source: Hemodialysis International - July 22, 2015 Category: Hematology Authors: Maggie Ming Yee Mok, Vincent Chi Chung Cheng, Sing Leung Lui, Lorraine Pui Yuen Kwan, Gary Chi Wang Chan, Desmond Yat Hin Yap, Tak Mao Chan, Wai Kei Lo Tags: Case Report Source Type: research

Polymorphisms in genes of respiratory control and sudden infant death syndrome
Abstract Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved in respiratory control mediated in the medulla oblongata contribute to SIDS. Therefore, a total of 366 SIDS cases and 421 controls were genotyped for 48 SNPs in 41 candidate genes. Genotyping was performed using Fluidigm nanofluidic technology. Results were obtained for 356 SIDS and 406 contr...
Source: International Journal of Legal Medicine - July 22, 2015 Category: Medical Law Source Type: research

Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
ConclusionWhile circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation. ADMA seems to be a possible new marker of prognosis of COPD and can be a novel therapeutic target for the treatment of COPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 22, 2015 Category: Respiratory Medicine Authors: Murat Aydin, Nejat Altintas, Levent Cem Mutlu, Bulent Bilir, Mustafa Oran, Feti Tülübaş, Birol Topçu, İsmail Tayfur, Volkan Küçükyalçin, Gizem Kaplan, Ahmet Gürel Tags: Original Article Source Type: research

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co‐existent bronchiectasis
ConclusionsIncreased levels of RA disease activity, severity and RA autoantibodies are demonstrated in patients with RA and co‐existent bronchiectasis compared to patients with RA alone, despite lower tobacco exposure. This study demonstrates that BRRA is a more severe systemic disease than RA alone. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - July 22, 2015 Category: Rheumatology Authors: Elizabeth Perry, Paul Eggleton, Anthony De Soyza, David Hutchinson, Clive Kelly Tags: Original Article Source Type: research

Disrupting differential hypoxia in peripheral veno-arterial extracorporeal membrane oxygenation
Patients receiving circulatory support with peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are at risk of developing differential hypoxia. This phenomenon occurs in patients with concomitant respiratory failure. Poorly oxygenated blood, ejected into the ascending aorta from the left ventricle, competes with retrograde flow from the ECMO circuit, potentially causing myocardial and cerebral ischaemia. In a recent Critical Care article, Hou et al. use an animal model of peripheral VA-ECMO to study the physiology of differential hypoxia. Their findings support a dual circuit hypothesis, and show how dif...
Source: Critical Care - July 22, 2015 Category: Intensive Care Authors: Matthew Cove Source Type: research

A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase [RESEARCH ARTICLE]
ABSTRACT Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes, which produce the majority of cellular energy, requires the coordinated expression and translation of both mitochondrially and nuclear-encoded proteins. The joint genetic architecture of this system complicates the basis of mitochondrial diseases, and mutations both in mitochondrial DNA (mtDNA)- and nuclear-encoded genes have been implicated in mitochondrial dysfunction. Previously, in a set of mitochondrial-nuclear introgression strains, we characterized a dual genome epistas...
Source: DMM Disease Models and Mechanisms - July 22, 2015 Category: Biomedical Science Authors: Holmbeck, M. A., Donner, J. R., Villa-Cuesta, E., Rand, D. M. Tags: RESEARCH ARTICLE Source Type: research

Electrical aspects of the osmorespiratory compromise: TEP responses to hypoxia in the euryhaline killifish (Fundulus heteroclitus) in freshwater and seawater [SHORT COMMUNICATION]
Chris M. Wood and Martin Grosell The osmorespiratory compromise, the trade-off between the requirements for respiratory and ionoregulatory homeostasis at the gills, becomes more intense during environmental hypoxia. One aspect that has been previously overlooked is possible change in transepithelial potential (TEP) caused by hypoxia, which will influence branchial ionic fluxes. Using the euryhaline killifish, we show that acute hypoxia reduces the TEP across the gills by approximately 10 mV in animals acclimated to both freshwater (FW) and seawater (SW), with a higher PO2 threshold in the former. TEP becomes nega...
Source: Journal of Experimental Biology - July 22, 2015 Category: Biology Authors: Wood, C. M., Grosell, M. Tags: SHORT COMMUNICATION Source Type: research

Flight-motor-driven respiratory airflow increases tracheal oxygen to nearly atmospheric level in blowflies (Calliphora vicina) [RESEARCH ARTICLE]
Lutz T. Wasserthal It is widely accepted that an efficient oxygen supply and removal of CO2 in small flying insects are sufficiently performed by diffusion with open spiracles. This paper shows that in the tethered flying blowfly, gas exchange occurs by autoventilation and unidirectional airflow. The air is inspired through the mesothoracic spiracles (Sp1) during the downstroke of the wings and is expired through the metathoracic spiracles (Sp2) during the upstroke. This directed airflow through the thoracic tracheal system was documented by pre-atrial pressure measurements at the Sp1 and Sp2, revealing a sub-atmospheric m...
Source: Journal of Experimental Biology - July 22, 2015 Category: Biology Authors: Wasserthal, L. T. Tags: RESEARCH ARTICLE Source Type: research

Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic patient prognosis
Conclusions: Neutrophil surface antigen (CD64, CD10, and CD16) could reflect sepsis severity. High CD64 expression and high RBA at early phase of sepsis might be associated with better prognosis, whereas high expression of CD10 and CD16 at late phase of sepsis might be associated with better prognosis. This article is protected by copyright. All rights reserved. (Source: Cytometry Part B: Clinical Cytometry)
Source: Cytometry Part B: Clinical Cytometry - July 22, 2015 Category: Molecular Biology Authors: Mi Hyun Bae, So Hee Park, Chan‐Jeoung Park, Eun‐Jung Cho, Bo‐Ra Lee, Young Jin Kim, Sang Hyuk Park, Young‐Uk Cho, Seongsoo Jang, Dong‐Keun Song, Sang‐Bum Hong Tags: Original Article Source Type: research

Bovine Viral Diarrhea Virus–Associated Disease in Feedlot Cattle
Bovine viral diarrhea virus (BVDv) is associated with bovine respiratory disease complex and other diseases of feedlot cattle. Although occasionally a primary pathogen, BVDv’s impact on cattle health is through the immunosuppressive effects of the virus and its synergism with other pathogens. The simple presence or absence of BVDv does not result in consistent health outcomes because BVDv is only one of many risk factors that contribute to disease syndromes. Current interventions have limitations and the optimum strategy for their uses to limit the health, production, and economic costs associated with BVDv have to be ca...
Source: Veterinary Clinics of North America: Food Animal Practice - July 22, 2015 Category: Veterinary Research Authors: Robert L. Larson Source Type: research

A Systematic Review of Bovine Respiratory Disease Diagnosis Focused on Diagnostic Confirmation, Early Detection, and Prediction of Unfavorable Outcomes in Feedlot Cattle
A large proportion of newly arrived feedlot cattle are affected with bovine respiratory disease (BRD). Economic losses could be reduced by accurate, early detection. This review evaluates the available literature regarding BRD confirmatory diagnostic tests, early detection methods, and modalities to estimate post-therapeutic prognosis or predict unfavorable or fatal outcomes. Scientific evidence promotes the use of haptoglobin to confirm BRD status. Feeding behavior, infrared thermography, and reticulorumen boluses are promising methods. Retrospective analyses of routinely collected treatment and cohort data can be used to...
Source: Veterinary Clinics of North America: Food Animal Practice - July 22, 2015 Category: Veterinary Research Authors: Barbara Wolfger, Edouard Timsit, Brad J. White, Karin Orsel Source Type: research

Plant-based Porcine Reproductive and Respiratory Syndrome Virus VLPs induce an immune response in mice
Publication date: Available online 22 July 2015 Source:Research in Veterinary Science Author(s): Laura Uribe-Campero, Alberto Monrroy-García, Ana L. Durán-Meza, María V. Villagrana-Escareño, Jaime Ruíz-García, Jesús Hernández, Héctor G. Núñez-Palenius, Miguel A. Gómez-Lim Porcine reproductive and respiratory syndrome virus (PRRSV) significantly affects the swine industry worldwide. An efficient, protective vaccine is still lacking. Here, we report for the first time the generation and purification of PRRSV virus like particles (VLPs) by expressing GP5, M and N genes in Nicotiana silvestris plants. The...
Source: Research in Veterinary Science - July 22, 2015 Category: Veterinary Research Source Type: research

Innate and adaptive immunity against Porcine Reproductive and Respiratory Syndrome Virus
Publication date: Available online 17 July 2015 Source:Veterinary Immunology and Immunopathology Author(s): Crystal L. Loving, Fernando A. Osorio, Michael P. Murtaugh, Federico A. Zuckermann Many highly effective vaccines have been produced against viruses whose virulent infection elicits strong and durable protective immunity. In these cases, characterization of immune effector mechanisms and identification of protective epitopes/immunogens has been informative for the development of successful vaccine programs. Diseases in which the immune system does not rapidly clear the acute infection and/or convalescent immuni...
Source: Veterinary Immunology and Immunopathology - July 22, 2015 Category: Veterinary Research Source Type: research

The role of infectious diseases in the catastrophic antiphospholipid syndrome
Publication date: Available online 22 July 2015 Source:Autoimmunity Reviews Author(s): M. Garcia-Carrasco, C. Mendoza-Pinto, S. Macias-Diaz, F. Vazquez de Lara, I. Etchegaray-Morales, J.L. Galvez-Romero, S. Mendez-Martinez, R. Cervera Catastrophic antiphospholipid syndrome (CAPS), also called “Asherson syndrome”, is a variant of the antiphospholipid syndrome (APS) that occurs in less than 1% of APS cases. The etiology of CAPS is uncertain; however, several triggering factors have been recognized. The most common of these are infectious diseases, particularly those of the respiratory tract. CAPS pathogenesis i...
Source: Autoimmunity Reviews - July 22, 2015 Category: Allergy & Immunology Source Type: research

Respiratory gating based on internal electromagnetic motion monitoring during stereotactic liver radiation therapy: First results.
CONCLUSION: Respiratory gating based on internal electromagnetic motion monitoring was performed for two liver SBRT patients. The gating added robustness to the dose delivery and ensured a high CTV dose even in the presence of large intrafraction motion. PMID: 26198651 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - July 22, 2015 Category: Cancer & Oncology Authors: Poulsen PR, Worm ES, Hansen R, Larsen LP, Grau C, Høyer M Tags: Acta Oncol Source Type: research