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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Bedside clinical and ultrasound-based approaches to the management of hemodynamic instability - Part I: focus on the clinical approach: Continuing Professional Development.
CONCLUSION: Not applicable. PMID: 25169906 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - August 29, 2014 Category: Anesthesiology Authors: Denault A, Vegas A, Royse C Tags: Can J Anaesth Source Type: research

Intercostal and forearm muscle deoxygenation during respiratory fatigue in patients with heart failure: potential role of a respiratory muscle metaboreflex.
Abstract The purpose of this study was to determine the effect of respiratory muscle fatigue on intercostal and forearm muscle perfusion and oxygenation in patients with heart failure. Five clinically stable heart failure patients with respiratory muscle weakness (age, 66±12 years; left ventricle ejection fraction, 34±3%) and nine matched healthy controls underwent a respiratory muscle fatigue protocol, breathing against a fixed resistance at 60% of their maximal inspiratory pressure for as long as they could sustain the predetermined inspiratory pressure. Intercostal and forearm muscle blood volume and oxygenati...
Source: Braz J Med Biol Res - August 29, 2014 Category: Research Authors: Moreno AM, Castro RR, Silva BM, Villacorta H, Junior MS, Nóbrega AC Tags: Braz J Med Biol Res Source Type: research

Middle East respiratory syndrome coronavirus: transmission and phylogenetic evolution.
Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) was first described in 2012 and, subsequently, many cases were reported with a lower case fatality rate than initial cases. Humans can become infected within their communities and transmission can then be amplified in the healthcare setting. Contact investigation among cases shows a variable amount of spread among family members and healthcare workers. So far, circulating virus strains remain similar under continuous monitoring, with no genetic changes. Here, we discuss the transmission pattern, phylogenetic evolution, and pathogenesis of MERS-CoV...
Source: Trends in Microbiology - August 29, 2014 Category: Microbiology Authors: Al-Tawfiq JA, Memish ZA Tags: Trends Microbiol Source Type: research

Spirometric reference values for healthy Han children aged 5–15 years in Guangzhou, Southern China
ConclusionsThe present spirometric reference equations are feasible for assessment of lung function among children in southern China. Further studies for establishment of reference values for Chinese children in other regions are needed. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 28, 2014 Category: Respiratory Medicine Authors: Mei Jiang, Yi Gao, Nan‐Shan Zhong, Wei‐Qing Chen, Wei‐Jie Guan, Jin‐Ping Zheng Tags: Original Article: Pulmonary Physiology Source Type: research

Back to Basics: Positioning the Patient
Positioning the surgical patient requires special attention from the entire surgical team because anesthetized or sedated patients are not able to reposition themselves when needed to relieve discomfort or alert team members of the need for repositioning. Perioperative nurses must pay attention to positioning details and the possibility of injury at all times during the patient’s procedure. This includes assessing the patient’s circulatory, respiratory, integumentary, musculoskeletal, and neurological structures to help ensure that the patient is properly positioned and safe from injury. (Source: AORN Journal)
Source: AORN Journal - August 28, 2014 Category: Nursing Authors: Lisa Spruce, Sharon A. Van Wicklin Tags: Featured Articles Source Type: research

Roche To Buy Intermune
Acquisition: Swiss drugmaker expands in respiratory disease field with $8.3 billion purchase of one-drug firm (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - August 28, 2014 Category: Chemistry Authors: Ann M. Thayer Source Type: research

Is the incidence of aliphatic amine‐induced occupational rhinitis and asthma underestimated?
ConclusionsThe frequency of amine‐induced OR/OA may be underestimated, particularly when cleaning products are incriminated. Comprehensive investigation of all cases is mandatory to ensure an efficient prevention policy and consequently a good clinical and socio‐occupational prognosis of occupational respiratory disease. Am. J. Ind. Med. 9999:1–8, 2014. © 2014 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)
Source: American Journal of Industrial Medicine - August 28, 2014 Category: Occupational Health Authors: Hervé Laborde‐Castérot, Nicole Rosenberg, Patricia Dupont, Robert Garnier Tags: Research Article Source Type: research

A symptom-related monitoring program following pulmonary embolism for the early detection of CTEPH: a prospective observational registry study
Conclusion: A follow-up program based on telephone monitoring of symptoms and further structured evaluation of symptomatic subjects can detect patients with CTEPH. CPET may serve as a complementary diagnostic tool. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 28, 2014 Category: Respiratory Medicine Authors: Matthias HeldAlexander HesseFranziska GöttRegina HollGudrun HübnerPhilipp KolbHeinz LangenTobias RomenFranziska WalterHans SchäfersHeinrike WilkensBerthold Jany Source Type: research

DOORS syndrome: Phenotype, genotype and comparison with Coffin‐Siris syndrome
DOORS syndrome (Deafness, Onychodystrophy, Osteodystrophy, mental Retardation, Seizures) is characterized mainly by sensorineural deafness, shortened terminal phalanges with small nails of hands and feet, intellectual deficiency, and seizures. Half of the patients with all clinical features have mutations in TBC1D24. We review here the manifestations of patients clinically diagnosed with DOORS syndrome. In this cohort of 32 families (36 patients) we detected 13 individuals from 10 families with TBC1D24 mutations. Subsequent whole exome sequencing in the cohort showed the same de novoSMARCB1 mutation (c.1130G>A), known t...
Source: American Journal of Medical Genetics Part C: Seminars in Medical Genetics - August 28, 2014 Category: Genetics & Stem Cells Authors: Philippe M. Campeau, Raoul C. Hennekam, Tags: Research Article Source Type: research

Helicobacter pylori and Extragastric Diseases
Abstract While Helicobacter pylori infection was initially revealed to be associated only with some gastroduodenal diseases, further studies have shown its possible role in several extragastric diseases. For idiopathic thrombocytopenic purpura, sideropenic anemia, and vitamin B12 deficiency, the diagnosis of H. pylori infection is recommended, and there are many other conditions such as cardiovascular, neurological, dermatological, and respiratory diseases in which H. pylori may possibly play a role. Interestingly, a potential role has also been described for GI neoplastic diseases, including colorectal and pancreatic ca...
Source: Helicobacter - August 28, 2014 Category: Gastroenterology Authors: Francesco Franceschi, Annalisa Tortora, Giovanni Gasbarrini, Antonio Gasbarrini Tags: Review Article Source Type: research

Correlation between levels of exhaled hydrogen sulfide and airway inflammatory phenotype in patients with chronic persistent asthma
ConclusionsExhaled H2S may be a useful marker of airway inflammation in asthma. (Source: Respirology)
Source: Respirology - August 28, 2014 Category: Respiratory Medicine Authors: Jing Zhang, Xinmao Wang, Yahong Chen, Wanzhen Yao Tags: Original Article Source Type: research

Caring for Critically Ill Patients with Ebola Virus Disease: Perspectives from West Africa.
Villar RC, Shindo N, Bausch D Abstract The largest ever Ebola virus disease outbreak is ravaging West Africa. The constellation of little public health infrastructure, low levels of health literacy, limited acute care and infection prevention and control resources, densely populated areas and a highly transmissible, lethal viral infection, have led to over 2000 confirmed, probable or suspected cases and, thus far, more than 1000 deaths. Ebola virus disease is characterized by a febrile severe illness, with profound gastrointestinal manifestations, and is complicated by intravascular volume depletion, shock, profou...
Source: American Journal of Respiratory and Critical Care Medicine - August 28, 2014 Category: Respiratory Medicine Authors: Fowler RA, Fletcher T, Fischer Ii WA, Lamontagne F, Jacob S, Brett-Major D, Lawler JV, Jacquerioz FA, Houlihan C, O'Dempsey T, Ferri M, Adachi T, Lamah MC, Bah EI, Mayet T, Schieffelin J, McLellan SL, Senga M, Kato Y, Clement C, Mardel S, Vallenas Bejar D Tags: Am J Respir Crit Care Med Source Type: research

Socio-demographic vulnerability to heatwave impacts in Brisbane, Australia: a time series analysis.
Conclusions: Heat-related ED visits increased during heatwaves. However, due to overlapping confidence intervals, variations across socioeconomic areas should be interpreted cautiously. Implications: ED data may be utilised for monitoring heat-related health impacts, particularly on the first day of heatwaves, to facilitate prompt interventions and targeted resource allocation. PMID: 25169903 [PubMed - as supplied by publisher] (Source: Australian and New Zealand Journal of Public Health)
Source: Australian and New Zealand Journal of Public Health - August 28, 2014 Category: Global & Universal Authors: Sam Toloo G, Guo Y, Turner L, Qi X, Aitken P, Tong S Tags: Aust N Z J Public Health Source Type: research

Retrospective Review Of Combined Sirolimus And Simvastatin Therapy In Lymphangioleiomyomatosis.
Conclusions.Therapy with sirolimus and simvastatin does not increase the prevalence of drug adverse events or alter the therapeutic effects of sirolimus. Background.: Combined simvastatin and sirolimus therapy reduce TSC2-null lesions and alveolar destruction in a mouse model of lymphangioleiomyomatosis (LAM), suggesting that therapy with both drugs may benefit LAM patients. Methods.: To determine whether simvastatin changed the prevalence of adverse events or altered the therapeutic effects of sirolimus, we recorded adverse events and changes in lung function in LAM patients treated with simvastatin plus sirolimus...
Source: Chest - August 28, 2014 Category: Respiratory Medicine Authors: Taveira-DaSilva AM, Jones AM, Julien-Williams P, Stylianou M, Moss J Tags: Chest Source Type: research

Nurse Practitioner/Physician Assistant Staffing and Critical Care Mortality.
Conclusions:NP/PAs appear to be a safe adjunct to the ICU team, supporting NP/PA management of the critically ill. Background: Intensive care units (ICUs) are increasingly staffed with nurse practitioners/ physician assistants (NP/PAs) but it is unclear how they influence quality of care. We examined the association between NP/PA staffing and in-hospital mortality for ICU patients. Methods: We used retrospective cohort data from the 2009-2010 Acute Physiology and Chronic Health Evaluation clinical information system and an ICU-level survey. We included patients (≥ 17 years of age) admitted to one of 29 adult medi...
Source: Chest - August 28, 2014 Category: Respiratory Medicine Authors: Costa DK, Wallace DJ, Barnato AE, Kahn JM Tags: Chest Source Type: research

The impact of lung cancer on survival of Idiopathic Pulmonary Fibrosis.
CONCLUSIONIn patients with IPF LC has a significant adverse impact on survival. Diagnosis and treatment of LC in IPF are burdened by an increased incidence of severe complicating events, apparently as lethal as the cancer itself. BACKGROUND: Lung cancer (LC) is frequently associated with idiopathic pulmonary fibrosis (IPF), despite this well-known association the outcome of LC in IPF patients is unclear. The objective of this study was to evaluate the impact of LC on survival of patients with associated IPF. METHODS: A total of 260 patients with IPF were reviewed and 186 IPF cases had complete clinical and follow-u...
Source: Chest - August 28, 2014 Category: Respiratory Medicine Authors: Tomassetti S, Gurioli C, Ryu J, Decker P, Ravaglia C, Tantalocco P, Buccioli M, Piciucchi S, Sverzellati N, Dubini A, Gavelli G, Chilosi M, Poletti V Tags: Chest Source Type: research

Delirium detection using EEG: what and how to measure?
Conclusions:In a homogenous population of non-sedated cardiothoracic surgery patients, we observed that relative delta power from an eyes-closed EEG recording with only two electrodes in a frontal-parietal derivation can distinguish post-cardiothoracic surgery patients with delirium from those without. Background: Despite its frequency and impact, delirium is poorly recognized in postoperative- and critically ill patients. EEG (electroencephalography) is highly sensitive to delirium, but as currently used, it is not diagnostic. To develop an EEG-based tool for delirium detection with a limited number of electrodes, we ...
Source: Chest - August 28, 2014 Category: Respiratory Medicine Authors: van der Kooi AW, Zaal IJ, Klijn FA, Koek HL, Meijer RC, Leijten FS, Slooter AJ Tags: Chest Source Type: research

Prolonged Clonal Spreading and Dynamic Changes in Antimicrobial Resistance of Escherichia coli ST68 Among Patients Who Stayed in a Respiratory Care Ward.
Abstract We collected a total of 83 bacteremic isolates of Escherichia coli with reduced susceptibility or resistance to third generation cephalosporins (TGCs) from 2007 to 2009. Isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The PFGE patterns revealed 2 highly correlated clusters (cluster E: 9 isolates; cluster G: 22 isolates) associated with this prolonged clonal spreading. Compared with cluster E isolates, cluster G isolates had a significantly higher rate of harboring aac(6')-Ib-cr (p < 0.05), and most of these were isolated during a later year than ...
Source: Journal of Medical Microbiology - August 28, 2014 Category: Microbiology Authors: Chen CM, Ke SC, Li CR, Chiou CS, Chang CC Tags: J Med Microbiol Source Type: research

Effects of pulmonary acid aspiration on the regional pulmonary blood flow within the first hour after injury: An observational study in rats.
CONCLUSIONS: From the first minute until fifty minutes after acid-induced acute lung injury, the PBF was consistently increased in the injured lung. These blood flow elevation was accompanied by significant hypoxemia. PMID: 25171591 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 28, 2014 Category: Hematology Authors: Richter T, Bergmann R, Pietzsch J, Patrick M, Mueller, Koch T Tags: Clin Hemorheol Microcirc Source Type: research

Impact of Hypertriglyceridemia on the Outcome of Acute Biliary Pancreatitis.
CONCLUSIONS:: High TG level (≥2.26 mmol/L or 200.11 mg/mL) may be a risk factor for severe ABP and the development of systemic and local complications in ABP. PMID: 25171545 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - August 28, 2014 Category: Journals (General) Authors: Zeng Y, Zhang W, Lu Y, Huang C, Wang X Tags: Am J Med Sci Source Type: research

Early Postnatal Respiratory Viral Infection Alters Hippocampal Neurogenesis, Cell Fate, and Neuron Morphology in the Neonatal Piglet.
Abstract Respiratory viral infections are common during the neonatal period in humans, but little is known about how early-life infection impacts brain development. The current study used a neonatal piglet model as piglets have a gyrencephalic brain with growth and development similar to human infants. Piglets were inoculated with porcine reproductive and respiratory syndrome virus (PRRSV) to evaluate how chronic neuroinflammation affects hippocampal neurogenesis and neuron morphology. Piglets in the neurogenesis study received one bromodeoxyuridine injection on postnatal day (PD) 7 and then were inoculated with PR...
Source: Brain, Behavior, and Immunity - August 28, 2014 Category: Neurology Authors: Conrad MS, Harasim S, Rhodes JS, Van Alstine WG, Johnson RW Tags: Brain Behav Immun Source Type: research

Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures.
Abstract Inhalation of hexavalent chromium [Cr(VI)] is associated with increased lung cancer risk among workers in several industries, most notably chromate production workers exposed to high concentrations of Cr(VI) (≥100μg/m(3)), for which clear exposure-response relationships and respiratory irritation and tissue damage have been reported. Data from this industry are used to assess lung cancer risk associated with environmental and current occupational exposures, occurring at concentrations that are significantly lower (approximately a million-fold). There is considerable uncertainty in the low dose extrapola...
Source: Toxicology - August 28, 2014 Category: Toxicology Authors: Proctor DM, Suh M, Campleman SL, Thompson CM Tags: Toxicology Source Type: research

Molecular and epidemiological study of human parechovirus infections in Taiwan, 2007-2012.
CONCLUSION: This study showed that HPeVs have been endemic in Taiwan for some years despite a low positive rate. The detection tests of HPeVs are needed to correct a diagnostic deficit in the surveillance system. The epidemiological and genetic information obtained from the present study would contribute to the understanding of the etiology and epidemiology of HPeVs. PMID: 25174670 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 28, 2014 Category: Microbiology Authors: Huang YP, Hsieh JY, Wu HS, Yang JY Tags: J Microbiol Immunol Infect Source Type: research

Non cystic fibrosis bronchiectasis: A longitudinal retrospective observational cohort study of Pseudomonas persistence and resistance
The hallmark of non-cystic fibrosis bronchiectasis is recurrent bronchial infection, yet there are significant gaps in our understanding of pathogen persistence, resistance and exacerbation frequencies. Pseudomonas aeruginosa is a key pathogen thought to be a marker of disease severity and progression, yet little is known if the infection risk is seen in those with milder disease or if there is any potential for eradication. These data are important in determining risk stratification and follow up. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 28, 2014 Category: Respiratory Medicine Authors: Melissa J. McDonnell, Hannah R. Jary, Audrey Perry, James G. MacFarlane, Katy L.M. Hester, Therese Small, Catherine Molyneux, John D. Perry, Katherine E. Walton, Anthony De Soyza Source Type: research

The efficacy of aerobic training in improving the inflammatory component of asthmatic children. Randomized trial
This study evaluated the effect of aerobic exercise on inflammation, functional capacity, respiratory muscle strength, quality of life and symptoms scores in asthmatic children.This was a 6-week randomized trial (NCT0192052) of 33 moderately asthmatic children (6–17 years).Patients were randomized aerobic training (exercise group; n = 14), while another group did not exercise (control; n = 19). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 28, 2014 Category: Respiratory Medicine Authors: Lívia Barboza de Andrade, Murilo C.A. Britto, Norma Lucena-Silva, Renan Garcia Gomes, José N. Figueroa Source Type: research

Hypermutation in Burkholderia cepacia complex is mediated by DNA mismatch repair inactivation and is highly prevalent in cystic fibrosis chronic respiratory infection.
In conclusion, in the present study we demonstrate for the first time that, MRS-deficient Bcc species mutators are highly prevalent and positively selected in CF chronic lung infections. Hypermutation therefore, might be playing a key role in increasing bacterial adaptability to the CF-airway environment, facilitating the persistence of chronic lung infections. PMID: 25217078 [PubMed - as supplied by publisher] (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - August 28, 2014 Category: Microbiology Authors: Martina P, Feliziani S, Juan C, Bettiol M, Gatti B, Yantorno O, Smania AM, Oliver A, Bosch A Tags: Int J Med Microbiol Source Type: research

Socioeconomic inequalities in smoking habits are still increasing in Italy
Conclusion: Smoking prevalence has declined in Italy during the last decade among the higher socioeconomic classes, but not among the lower. This enlarging socioeconomic inequality mainly reflects a different trend in smoking initiation. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - August 27, 2014 Category: Consumer Health News Authors: Giuseppe VerlatoSimone AccordiniGiang NguyenPierpaolo MarchettiLucia CazzolettiMarcello FerrariLeonardo AntonicelliFrancesco AttenaValeria BellisarioRoberto BonoLamberto BriziarelliLucio CasaliAngelo Guido CorsicoAlessandro FoisMariaGrazia PanicoPavilio P Source Type: research

Out of the frying pan into the fire--the never forgiving complex congenital heart: a case of liquefied splenic infarct post-electrophysiology ablation
A 36-year-old man born with pulmonary atresia intact ventricular septum, atrial septal defect and Ebstein anomaly with hypoplastic right heart (figure 1 and online supplementary video). Waterson shunt had been performed in childhood, but over a period of time it had occluded with pulmonary circulation being dependent on bronchopulmonary collaterals. He is on targeted therapy for pulmonary hypertension. He was symptomatic with intermittent focal atrial tachycardia, despite amiodarone therapy. Coumarin therapy was avoided due to risk of massive haemoptysis. At electrophysiology, he had an atrial flutter circuit, which was re...
Source: Heart Asia - August 27, 2014 Category: Cardiology Authors: Rafiq, I., Deaville-Lees, D., Freeman, L. J. Tags: Images in cardiovascular medicine Source Type: research

Nasal and ocular amyloidosis in a 15-year-old horse
Localized nasal, conjunctival and corneal amyloidosis was diagnosed in a 15-year-old pony with nasal and conjunctival masses and severe dyspnoea. Multiple swellings had been evident in the nostrils for at least two years and had gradually increased in size before presentation due to dyspnoea and exercise intolerance. Surgical debulking of the masses was performed and histological examination revealed large amounts of extracellular, hyaline, eosinophilic, Congo red positive material in the lamina propria of the nasal mucosa. A tentative diagnosis of localized nasal amyloidosis was made. The treatment relieved the clinical s...
Source: Acta Veterinaria Scandinavica - August 27, 2014 Category: Veterinary Research Authors: Liv ØstevikGjermund GunnesGustavo de SouzaTale WienRandi Sørby Source Type: research

Purified deoxynivalenol or feed restriction reduces mortality in rainbow trout, Oncorhynchus mykiss (Walbaum), with experimental bacterial coldwater disease but biologically relevant concentrations of deoxynivalenol do not impair the growth of Flavobacterium psychrophilum
Abstract Diets containing deoxynivalenol (DON) were fed to rainbow trout Oncorhynchus mykiss (Walbaum) for 4 weeks followed by experimental infection (intraperitoneal) with Flavobacterium psychrophilum (4.1 × 106 colony‐forming units [CFU] mL−1). Mortality of rainbow trout fed either 6.4 mg kg−1 DON or trout pair‐fed the control diet was significantly reduced (P < 0.05) in comparison with trout fed the control diet to apparent satiation (<0.1 mg kg−1 DON). In a second experiment, trout were fed one of three experimental diets; a control diet, a diet produced with corn naturally contaminated with ...
Source: Journal of Fish Diseases - August 27, 2014 Category: Zoology Authors: I A Ryerse, J M Hooft, D P Bureau, M A Hayes, J S Lumsden Tags: Original Article Source Type: research

Complete coding regions of the prototypes enterovirus B93 and C95: Phylogenetic analyses of the P1 and P3 regions of EV‐B and EV‐C strains
Complete coding regions were sequenced for two new enterovirus genomes: EV‐B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV‐C95 from a French soldier with acute gastroenteritis in Djibouti. The EV‐B93 P1 had more than 30% nucleotide divergence from other EV‐B types, with highest similarity to E‐15 and EV‐B80. The P1 nucleotide sequence of EV‐C95 was most similar, 71%, to CV‐A21. Complete coding regions for the new enteroviruses were compared with those of 135 EV‐B and 176 EV‐C strains representing all types availab...
Source: Journal of Medical Virology - August 27, 2014 Category: Virology Authors: N. Junttila, N. Lévêque, L.O. Magnius, J.P. Kabue, J. J. Muyembe‐Tamfum, J. Maslin, B. Lina, H. Norder Tags: Research Article Source Type: research

Sequential infusion of donor‐derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation
Donor lymphocyte infusion (DLI) is often given to induce a graft‐versus‐leukemia (GVL) effect after allogeneic hematopoietic stem cell transplantation (HSCT). However, efficacy of DLI is limited in most hematologic cancers. As antigen presenting cells, dendritic cells (DC) bolster immune responses. We conducted a Phase I trial testing the coinfusion of DC followed by DLI. DC were generated by culturing peripheral blood mononuclear cells from HLA matched‐related donors in GM‐CSF and IL‐4 for 7 days, followed by TNF‐α for 3 days. DC were administered intravenously on 3 dose levels (5 × 106; 1 × 107; 5 × 107 c...
Source: American Journal of Hematology - August 27, 2014 Category: Hematology Authors: Vincent T. Ho, Haesook T. Kim, Grace Kao, Corey Cutler, James Levine, Jacalyn Rosenblatt, Robin Joyce, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, David Avigan, Edwin P. Alyea Tags: Research Article Source Type: research

Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents.
Abstract Complex sensations accompany the activation of sensory neurons within the respiratory system, yet little is known about the organization of sensory pathways in the brain that mediate these sensations. In the present study, we employ anterograde viral neuroanatomical tract tracing with isogenic self-reporting recombinants of HSV-1 strain H129 to map the higher brain regions in receipt of vagal sensory neurons arising from the trachea versus the lungs, and single-cell PCR to characterize the phenotype of sensory neurons arising from these two divisions of the respiratory tree. The results suggest that the up...
Source: Brain Structure and Function - August 27, 2014 Category: Neuroscience Authors: McGovern AE, Davis-Poynter N, Yang SK, Simmons DG, Farrell MJ, Mazzone SB Tags: Brain Struct Funct Source Type: research

A randomised controlled double‐blind clinical trial of 17‐hydroxyprogesterone caproate for the prevention of preterm birth in twin gestation (PROGESTWIN): evidence for reduced neonatal morbidity
ConclusionsIntramuscular 17OHPC therapy did not reduce PTB before 37 weeks of gestation in unselected twin pregnancies. Nonetheless, 17OHPC significantly reduced neonatal morbidity parameters and increased birthweight. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - August 27, 2014 Category: OBGYN Authors: J Awwad, IM Usta, G Ghazeeri, N Yacoub, J Succar, S Hayek, W Saasouh, AH Nassar Tags: Original Article Source Type: research

The OPTIMIST-A trial: evaluation of minimally-invasive surfactant therapy in preterm infants 25-28 weeks gestation
DiscussionMinimally-invasive surfactant therapy has the potential to ease the burden of respiratory morbidity in preterm infants. The trial will provide definitive evidence on the effectiveness of this approach in the care of preterm infants born at 25-28 weeks gestation.Trial registration: Australia and New Zealand Clinical Trial Registry: ACTRN12611000916943; ClinicalTrials.gov: NCT02140580. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - August 27, 2014 Category: Pediatrics Authors: Peter DargavilleCamille KamlinAntonio De PaoliJohn CarlinFrancesca OrsiniRoger SollPeter Davis Source Type: research

Measures of cardiorespiratory fitness in relation to measures of body size and composition among children
ConclusionsWhile assessing cardiorespiratory fitness, LM is the most appropriate measure of body size or composition for scaling of WMAX and VO2MAX, because scaling by body weight introduces confounding by body adiposity. (Source: Clinical Physiology and Functional Imaging)
Source: Clinical Physiology and Functional Imaging - August 27, 2014 Category: Radiology Authors: Tuomo Tompuri, Niina Lintu, Kai Savonen, Tomi Laitinen, David Laaksonen, Jarmo Jääskeläinen, Timo A. Lakka Tags: Original Article Source Type: research

Combined T2‐preparation and two‐dimensional pencil‐beam inner volume selection
ConclusionWhen compared with conventional T2‐Prep, the 2D‐T2‐Prep improves vessel sharpness and decreases respiratory ghosting while preserving both SNR and CNR. It may also acquire rFoV images for accelerated data acquisition. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - August 27, 2014 Category: Radiology Authors: Andrew J Coristine, Ruud B van Heeswijk, Matthias Stuber Tags: Note Source Type: research

A clinical in-hospital prognostic score for acute exacerbations of COPD
Conclusions: A score using simple clinical variables has robust properties for predicting the risk of in-hospital death in patients hospitalized for AECOPD. Adding cardiac comorbidities to the original score increased its sensitivity. (Source: Respiratory Research)
Source: Respiratory Research - August 27, 2014 Category: Respiratory Medicine Authors: Nicolas RocheJean-Michel ChavaillonCyril MaurerMahmoud ZureikJacques Piquet Source Type: research

Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic patients
Background: We investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma. Methods: 63 (36?F; mean age 42?yr???14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ?14; FEV1/FVC 75%???8) underwent the methacholine challenge test (MCT). The degree of BHR was expressed as PD20 (in ?g) and as ?FVC%. Peripheral airway resistance was measured pre- and post-MCT by impulse oscillometry system (IOS) and expressed as R5-R20 (in kPa sL?1). Results: All...
Source: Respiratory Research - August 27, 2014 Category: Respiratory Medicine Authors: Veronica AlfieriMarina AielloRoberta PisiPanagiota TzaniElisa MarianiEmilio MarangioDario OlivieriGabriele NicoliniAlfredo Chetta Source Type: research

Self-management support interventions to reduce health care utilisation without compromising outcomes: a systematic review and meta-analysis
Conclusions: Self-management support interventions can reduce health service utilization without compromising patient health outcomes, although effects were generally small, and the evidence was strongest in respiratory and cardiovascular disorders. Further work is needed to determine which components of self-management support are most effective. (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 27, 2014 Category: Journals (General) Authors: Maria PanagiotiGerry RichardsonNicola SmallElizabeth MurrayAnne RogersAnne KennedyStanton NewmanPeter Bower Source Type: research

Intrapartum and neonatal outcome of screening non‐stress test (NST) compared with no screening NST in healthy women at 40–40 (+6) weeks of gestation
ConclusionRoutine performing NST at the gestational age of 40–40+6 weeks has no benefit in intrapartum and neonatal outcome. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 27, 2014 Category: OBGYN Authors: Patcharin Kiettisanpipop, Vorapong Phupong Tags: Original Article Source Type: research

Cervical vertebrae maturation, dentoalveolar, head postural and respiratory parameters in predicting the stable outcome of face-mask treatment.
CONCLUSIONS/IMPLICATIONS: Presence of non-skeletal cephalometric factors more closely associated with stability of face-mask treatment rather than skeletal cephalometric factors at the initial stage are confirmed. PMID: 25164062 [PubMed - as supplied by publisher] (Source: European Journal of Orthodontics)
Source: European Journal of Orthodontics - August 27, 2014 Category: Dentistry Authors: Lee KM, Chung DH, Lee JW, Lee SM Tags: Eur J Orthod Source Type: research

A randomised controlled double-blind clinical trial of 17-hydroxyprogesterone caproate for the prevention of preterm birth in twin gestation (PROGESTWIN): evidence for reduced neonatal morbidity.
CONCLUSIONS: Intramuscular 17OHPC therapy did not reduce PTB before 37 weeks of gestation in unselected twin pregnancies. Nonetheless, 17OHPC significantly reduced neonatal morbidity parameters and increased birthweight. PMID: 25163819 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 27, 2014 Category: OBGYN Authors: Awwad J, Usta I, Ghazeeri G, Yacoub N, Succar J, Hayek S, Saasouh W, Nassar A Tags: BJOG Source Type: research

Veterans With Chronic Obstructive Pulmonary Disease Achieve Clinically Relevant Improvements in Respiratory Health After Pulmonary Rehabilitation.
CONCLUSIONS:: Pulmonary rehabilitation improves respiratory health in veterans with chronic obstructive pulmonary disease and decreases RR health care utilization. PMID: 25166259 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - August 27, 2014 Category: Rehabilitation Authors: Major S, Moreno M, Shelton J, Panos RJ Tags: J Cardiopulm Rehabil Prev Source Type: research