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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Rash, Disseminated Intravascular Coagulation and Legionella: Episode 10 and a rewind into the past
This article synthesizes all reported cases of Legionella pneumonia associated with cutaneous manifestations as well as cases presenting with DIC. Furthermore, this manuscript illustrates the correlation between cutaneous and coagulopathic manifestations, and morbidity and mortality from legionella pneumonia. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - May 8, 2015 Category: Respiratory Medicine Source Type: research

Bronchopulmonary Kaposi’s sarcoma
Publication date: Available online 7 May 2015 Source:Respiratory Medicine Case Reports Author(s): Nada Bashar , Nicholas Innes , Julian Orrell (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - May 8, 2015 Category: Respiratory Medicine Source Type: research

Pneumonia and disseminated bacteremia with Pasteurella multocida in the immune competent host: A case report and a review of the literature
We report a 70 year old Caucasian female with occurrence of a P. multocida pneumonia and resultant bacteremia in an immunocompetent host. Similar to prior case studies, the patient presented with a history of having significant exposure to animals at her residence. We undertook a review of the literature for reports of disseminated P. multocida in immunocompotent hosts in the absence of the typical presentation of cellulitis. Literature has suggested the possibility of nasal and oropharyngeal colonization of patients with frequent interactions with domestic animals, in whom periods of suppressed immune function may lead to...
Source: Respiratory Medicine Case Reports - May 8, 2015 Category: Respiratory Medicine Source Type: research

Pneumothorax triggered by the combination of gefitinib and amrubicin and treated with endobronchial silicone spigots
We report a case in which a male patient with advanced non-small cell lung cancer (NSCLC) developed repetitive pneumothorax after receiving a combination of the chemotherapeutic drugs gefitinib and amrubicin (GEF + AMR). Both episodes of pneumothorax occurred on the 3rd day of GEF + AMR administration. Tube thoracostomy was performed, but pulmonary air leaks persisted in the second pneumothorax. Whereas surgical intervention was not applicable because of poor respiratory reserve, the chest tube was successfully removed by endoscopic occlusion of bronchopleural fistula with endobronchial Watanabe spigots (EWSs), a type of s...
Source: Respiratory Medicine Case Reports - May 8, 2015 Category: Respiratory Medicine Source Type: research

Chronic Mould Exposure as a Risk Factor for Severe Community Acquired Pneumonia in a Patient Requiring Extra Corporeal Membrane Oxygenation
Publication date: Available online 7 May 2015 Source:Respiratory Medicine Case Reports Author(s): Stephanie Thomas , Ibrahim Hassan , Julian Barker , Alan Ashworth , Anita Barnes , Igor Fedor , Lee Feddy , Tim Hayes , Ignacio Malagon , Sarah Stirling , Lajos Szentgyorgyi , Ken Mutton , Malcolm Richardson A previously fit and well man developed acute respiratory failure due to environmental mould exposure from living in damp rental accommodation. Despite aggressive intensive care management he rapidly deteriorated and required respiratory and cardiac Extracorporeal Membrane Oxygenation. We hypothesize that poor domiciliar...
Source: Respiratory Medicine Case Reports - May 8, 2015 Category: Respiratory Medicine Source Type: research

Efficacy of non‐invasive mechanical ventilation in the general ward in patients with chronic obstructive pulmonary disease admitted for hypercapnic acute respiratory failure and pH < 7.35: a feasibility pilot study
ConclusionIn a non‐‘highly protected’ environment such as an experienced medical ward of a rural hospital, NIV is effective not only in patients with mild, but also with severe forms of RA. MR did not vary according to the level of initial pH. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - May 8, 2015 Category: Internal Medicine Authors: S. Fiorino, L. Bacchi‐Reggiani, E. Detotto, M. Battilana, E. Borghi, C. Denitto, C. Dickmans, B. Facchini, R. Moretti, S. Parini, M. Testi, A. Zamboni, A. Cuppini, L. Pisani, S. Nava Tags: Original Article Source Type: research

Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency
In this study, we hypothesized that this enzymatic ACAD activity is required for full fatty acid oxidation capacity in cells expressing high levels of ACAD9 and that loss of this function is important in determining phenotype in ACAD9-deficient patients. First, we confirmed that HEK293 cells express ACAD9 abundantly. Then, we showed that ACAD9 knockout in HEK293 cells affected long-chain fatty acid oxidation along with Cl, both of which were rescued by wild type ACAD9. Further, we evaluated whether the loss of ACAD9 enzymatic fatty acid oxidation affects clinical severity in patients with ACAD9 mutations. The effects on AC...
Source: Human Molecular Genetics - May 8, 2015 Category: Genetics & Stem Cells Authors: Schiff, M., Haberberger, B., Xia, C., Mohsen, A.-W., Goetzman, E. S., Wang, Y., Uppala, R., Zhang, Y., Karunanidhi, A., Prabhu, D., Alharbi, H., Prochownik, E. V., Haack, T., Haberle, J., Munnich, A., Rotig, A., Taylor, R. W., Nicholls, R. D., Kim, J.-J., Tags: ARTICLES Source Type: research

Cryptococcose cutanée mimant un carcinome basocellulaire et révélant une atteinte systémique sur immunodéficience acquise
We report a case of disseminated cryptococcosis in acquired immunodeficiency syndrome revealed by unusual skin lesions. Observation A 52-year-old patient consulted for two crusty ulcerative lesions situated on the left supraorbital and on the nasal tip that appeared 6months ago. He also reported respiratory symptoms present since one year, with dry cough and dyspnea, chronic headache and vomiting with no alteration in visual acuity. The mycological study of the skin biopsy on both lesions isolated Cryptococcus neoformans as well as in the sputum and cerebrospinal fluid. Serology of human immunodeficiency virus infection w...
Source: Journal of Medical Mycology - May 8, 2015 Category: Biology Source Type: research

Conjugating influenza a (H1N1) antigen to n‐trimethylaminoethylmethacrylate chitosan nanoparticles improves the immunogenicity of the antigen after nasal administration
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - May 8, 2015 Category: Virology Authors: Qingfeng Liu, Xiaoyao Zheng, Chi Zhang, Xiayan Shao, Xi Zhang, Qizhi Zhang, Xinguo Jiang Tags: Research Article Source Type: research

Evaluation of a PCR/ESI‐MS platform to identify respiratory viruses from nasopharyngeal aspirates
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - May 8, 2015 Category: Virology Authors: Yong Lin, Yongfeng Fu, Menghua Xu, Liyun Su, Lingfeng Cao, Jin Xu, Xunjia Cheng Tags: Research Article Source Type: research

Serum biomarkers of treatment response within a randomized clinical trial for pulmonary tuberculosis
Biomarkers for monitoring response to anti-tuberculosis treatment are needed. We explored immune markers previously published as having predictive capability for 8 week culture status in 39 adults enrolled in a clinical trial in Kampala, Uganda. (Source: Tuberculosis)
Source: Tuberculosis - May 8, 2015 Category: Respiratory Medicine Authors: A. Jayakumar, E. Vittinghoff, M.R. Segal, W.R. MacKenzie, J.L. Johnson, P. Gitta, J. Saukkonen, J. Anderson, M. Weiner, M. Engle, C. Yoon, M. Kato-Maeda, P. Nahid, Tuberculosis Trials Consortium Tags: Diagnostics Source Type: research

The fibroblast growth factor-2 arrests growth and immunomodulates host response in macrophages
In this study, using M. avium infection of macrophages as a model, we systematically studied the effect of fibroblast growth factor-2 (FGF-2) on M. avium infection of macrophages. Our results showed that M. (Source: Tuberculosis)
Source: Tuberculosis - May 8, 2015 Category: Respiratory Medicine Authors: Jianjun Wang, Zeyou Wang, Yongliang Yao, Jianhong Wu, Xin Tang, Tao Gu, Guangxin Li Tags: Non-Tuberculous Mycobacteria: General Source Type: research

Effects of Denosumab and Calcitriol on Severe Secondary Hyperparathyroidism in Dialysis Patients with Low Bone Mass.
CONCLUSIONS: Denosumab allows for supra-physiologic doses of calcitriol resulting in decreased parathyroid secretion and parathyroid hyperplasia. Supervised administration and weekly laboratory and clinical monitoring of serum calcium are recommended during the first month to prevent hypocalcemia. PMID: 25955225 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - May 8, 2015 Category: Endocrinology Authors: Chen CL, Chen NC, Liang HL, Hsu CY, Chou KJ, Fang HC, Lee PT Tags: J Clin Endocrinol Metab Source Type: research

Risk factors for Noninvasive Ventilation failure in cancer patients in the Intensive Care Unit: a retrospective cohort study
To identify risk factors for Noninvasive ventilation (NIV) failure in cancer patients with acute respiratory failure (ARF). (Source: Journal of Critical Care)
Source: Journal of Critical Care - May 8, 2015 Category: Intensive Care Authors: Juliana Carvalho Ferreira, Pedro Medeiros, Francinni Mambrini Rego, Pedro Caruso Source Type: research

Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function.
Abstract Asthma development and pathogenesis are influenced by the interactions of airway epithelial cells and innate and adaptive immune cells in response to allergens. Oxidative stress is an important mediator of asthmatic phenotypes in these cell types. Nrf2 is a redox-sensitive transcription factor that is the key regulator of the response to oxidative and environmental stress. We previously demonstrated that Nrf2-deficient mice have heightened susceptibility to asthma, including elevated oxidative stress, inflammation, mucus, and airway hyperresponsiveness (AHR). Here we dissected the role of Nrf2 in lung epit...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Sussan TE, Gajghate S, Chatterjee S, Mandke P, McCormick S, Sudini K, Kumar S, Breysse PN, Diette GB, Sidhaye VK, Biswal S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

The role of Macrophage Migration Inhibitory Factor (MIF) in age-related lung disease.
Abstract The prevalence of many common respiratory disorders, including pneumonia, Chronic Obstructive Lung Disease, pulmonary fibrosis and lung cancer increases with age. Little is known of the host factors that may predispose individuals to such diseases. Macrophage Migration Inhibitory Factor (MIF) is a potent upstream regulator of the immune system. MIF is encoded by variant alleles that occur commonly in the population. In addition to its role as a pro-inflammatory cytokine, a growing body of literature demonstrates that MIF influences diverse molecular processes important for the maintenance of cellular homeo...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Sauler M, Bucala R, Lee PJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR protein.
Abstract Corticosteroid insensitivity, which is induced by cigarette smoke extract (CSE), is a significant barrier when treating chronic obstructive pulmonary disease (COPD). Erythromycin (EM) has been shown to have an anti-inflammatory role in some chronic airway inflammatory diseases, particularly diffuse panbronchiollitis (DBP) and cystic pulmonary fibrosis. Here, we explored whether the combination therapy of EM and dexamethasone (Dex) could reverse corticosteroid insensitivity and investigated the molecular mechanism by which this occurs. We demonstrated that the combination of EM and Dex restored corticostero...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Sun XJ, Li ZH, Zhang Y, Zhou G, Zhang JQ, Deng JM, Bai J, Liu GN, Li MH, MacNee W, Zhong XN, He ZY Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Linking progression of fibrotic lung remodeling and ultrastructural alterations of alveolar epithelial type II cells in the amiodarone mouse model.
Abstract Chronic injury of alveolar epithelial type II cells (AE2 cells) represents a key event in the development of lung fibrosis in animal models and in humans, such as Idiopathic Pulmonary Fibrosis (IPF). Intratracheal delivery of amiodarone to mice results in a profound injury and macroautophagy dependent apoptosis of AE2 cells. Increased autophagy manifested in AE2 cells by disturbances of the intracellular surfactant . Hence, we hypothesized that ultrastructural alterations of the intracellular surfactant pool are signs of epithelial stress correlating with the severity of fibrotic remodeling. Using design b...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Birkelbach B, Lutz D, Ruppert C, Henneke I, Lopez-Rodriguez E, Günther A, Ochs M, Mahavadi P, Knudsen L Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Plasma Gelsolin Improves Lung Host Defense against Pneumonia by Enhancing Macrophage NOS3 Function.
Abstract Plasma gelsolin (pGSN) functions as part of the 'extracellular actin scavenging system' but its potential to improve host defense against infection has not been studied. In a mouse model of primary pneumococcal pneumonia, rhu-pGSN caused enhanced bacterial clearance, reduced acute inflammation and improved survival. In vitro, rhu-pGSN rapidly improved lung macrophage uptake and killing of bacteria (S. pneumoniae, E. coli, F. tularensis). pGSN triggers activating phosphorylation (ser1177) of macrophage nitric oxide synthase type III (NOS3), an enzyme with important bactericidal functions in lung macrophages...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Yang Z, Chiou TT, Stossel TP, Kobzik L Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Alterations of lung microbiota in a mouse model of LPS-induced lung injury.
Abstract Acute lung injury (ALI) and the more severe acute respiratory distress syndrome are common responses to a variety of infectious and non-infectious insults. We used a mouse model of ALI induced by intratracheal administration of sterile bacterial wall lipopolysacharide (LPS) to investigate the changes in innate lung microbiota and study microbial community reaction to lung inflammation and barrier dysfunction induced by endotoxin insult. One group of C57BL/6J mice received LPS via intratracheal injection (n=6), other - sterile water (n=7). Bronchoalveolar lavage (BAL) was performed at 72h after treatment. B...
Source: Am J Physiol Lung Ce... - May 8, 2015 Category: Respiratory Medicine Authors: Poroyko V, Meng F, Meliton A, Afonyushkin T, Ulanov A, Semenyuk E, Latif O, Tesic V, Birukova AA, Birukov KG Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Trends in Tracheostomy for Mechanically Ventilated Patients in the United States, 1993-2012.
CONCLUSIONS: Over the past two decades, tracheostomy utilization rose substantially in the US until 2008 when utilization began to decline. The observed dramatic increase in discharge of tracheostomy patients to long-term care facilities may have significant implications for clinical care, healthcare costs, policy, and research. Future studies should include long-term facilities when analyzing outcomes of tracheostomy. PMID: 25955332 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 8, 2015 Category: Respiratory Medicine Authors: Mehta AB, Syeda SN, Bajpayee L, Cooke CR, Walkey AJ, Wiener RS Tags: Am J Respir Crit Care Med Source Type: research

Role of Chitinase 3-like-1 in IL-18-induced Pulmonary Type-1, -2 and -17 Inflammation, Alveolar Destruction and Airway Fibrosis in the Murine Lung.
Abstract Chitinase 3-like 1 (Chi3l1), which is also called YKL-40 in man and BRP-39 in mice, is the prototypic chitinase like protein (CLP). Recent studies have highlighted its impressive ability to regulate the nature of tissue inflammation, and the magnitude of tissue injury and fibroproliferative repair. This can be nicely appreciated in studies which highlight its induction after cigarette smoke exposure where it inhibits alveolar destruction and the genesis of pulmonary emphysema. IL-18 is also known to be induced and activated by cigarette smoke and, in murine models, the IL-18 pathway has been shown to be ne...
Source: Am J Respir Cell Mol... - May 8, 2015 Category: Respiratory Medicine Authors: Kang MJ, Yoon CM, Nam M, Kim DH, Choi JM, Lee CG, Elias JA Tags: Am J Respir Cell Mol Biol Source Type: research

Reduced EPAC1 Activity Leads to Slowed Microtubule Polymerization in Cystic Fibrosis Epithelial Cells.
Abstract The regulation of microtubule dynamics in cystic fibrosis (CF) epithelial cells and the consequences of reduced rates of microtubule polymerization on downstream CF cellular events, such as cholesterol accumulation, a marker of impaired intracellular transport, is explored here. It is identified that microtubules in both CF cell models and in primary CF nasal epithelial cells re-polymerize at a slower rate compared to respective controls. Previous studies suggest a role for cAMP in modulating organelle transport in CF cells implicating a role for exchange protein activated by cAMP (EPAC1), a regulator of m...
Source: Am J Respir Cell Mol... - May 8, 2015 Category: Respiratory Medicine Authors: Rymut SM, Ivy T, Corey DA, Cotton CU, Burgess JD, Kelley TJ Tags: Am J Respir Cell Mol Biol Source Type: research

Efficacy of Trypsin in Treating Coral Snake Envenomation in the Porcine Model.
This study assesses the efficacy of trypsin to treat coral snake envenomation in an in vivo porcine model. A randomized, blinded study was conducted. Subjects were 13 pigs injected subcutaneously with 1 mL of eastern coral snake venom (10 mg/mL) in the right distal hind limb. After 1 min, subjects were randomized to have the envenomation site injected with either 1 mL of saline or 1 mL of trypsin (100 mg/mL) by a blinded investigator. Clinical endpoint was survival for 72 h or respiratory depression defined as respiratory rate <15 breaths per minute, falling pulse oximetry, or agonal respirations. Fisher's exact ...
Source: Journal of Medical Toxicology - May 8, 2015 Category: Toxicology Authors: Parker-Cote JL, O'Rourke DP, Brewer KL, Lertpiriyapong K, Punja M, Bush SP, Miller SN, Meggs WJ Tags: J Med Toxicol Source Type: research

Improved accuracy of markerless motion tracking on bone suppression images: preliminary study for image-guided radiation therapy (IGRT).
This study was performed to evaluate the usefulness of bone suppression image processing in image-guided radiation therapy. We demonstrated the improved accuracy of markerless motion tracking on bone suppression images. Chest fluoroscopic images of nine patients with lung nodules during respiration were obtained using a flat-panel detector system (120 kV, 0.1 mAs/pulse, 5 fps). Commercial bone suppression image processing software was applied to the fluoroscopic images to create corresponding bone suppression images. Regions of interest were manually located on lung nodules and automatic target tracking was conducted...
Source: Physics in Medicine and Biology - May 8, 2015 Category: Physics Authors: Tanaka R, Sanada S, Sakuta K, Kawashima H Tags: Phys Med Biol Source Type: research

Shewanella mangrovi sp. nov., an acetaldehyde-degrading bacterium isolated from mangrove sediment.
Abstract A taxonomic study was carried out on strain YQH10T, which was isolated from mangrove sediment collected from Zhangzhou of China during the screening of acetaldehyde-degrading bacteria. Cells of strain YQH10T were Gram-negative, rods, pale-brown pigmented. Growth was observed at salinities from 0 to 11 % and at temperatures from 4 to 42 °C. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain YQH10T is affiliated to the genus Shewanella, showing the highest similarity with Shewanella haliotis DW01T (95.7 %) and other Shewanella species (91.4-95.6%). The principal fatty acids were is...
Source: International Journal of Systematic and Evolutionary Microbiology - May 8, 2015 Category: Microbiology Authors: Liu Y, Shang XX, Yi ZW, Gu L, Zeng RY Tags: Int J Syst Evol Microbiol Source Type: research

Dopamine receptor blockade improves pulmonary gas exchange but decreases exercise performance in healthy humans.
This article is protected by copyright. All rights reserved. PMID: 25952760 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 8, 2015 Category: Physiology Authors: Tedjasaputra V, Bryan TL, van Diepen S, Moore LE, Bouwsema MM, Welsh RC, Petersen SR, Stickland MK Tags: J Physiol Source Type: research

Three brainstem areas involved in respiratory rhythm generation in bullfrogs.
This article is protected by copyright. All rights reserved. PMID: 25952282 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 8, 2015 Category: Physiology Authors: Baghdadwala MI, Duchcherer M, Paramonov J, Wilson RJ Tags: J Physiol Source Type: research

Neonatal Genetic Variation in Steroid Metabolism and Key Respiratory Function Genes and Perinatal Outcomes in Single and Multiple Courses of Corticosteroids
Conclusion Steroid metabolism and respiratory gene SNPs are associated with respiratory outcomes and SGA in patients exposed to ACS. Risks for respiratory outcomes are affected by minor allele carriage as well as by treatment with multiple ACS.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 8, 2015 Category: Perinatology & Neonatology Authors: Borowski, K.S.Clark, E.A.S.Lai, Y.Wapner, R.J.Sorokin, Y.Peaceman, A.M.Iams, J.D.Leveno, K.J.Harper, M.Caritis, S.N.Miodovnik, M.Mercer, B.M.Thorp, J.M.O'Sullivan, M.J.Ramin, S.M.Carpenter, M.W.Rouse, D.J.Sibai, B. Tags: Original Article Source Type: research

Rehospitalization Following Neonatal Cardiac Surgery: Risk Factors and Outcomes
Conclusion The majority of children with HLHS and TGA have unplanned readmissions. Home-care surveillance programs may reduce health-care utilization in this population.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - May 8, 2015 Category: Perinatology & Neonatology Authors: Soliman, AmiraAggarwal, SanjeevNatarajan, Girija Tags: Original Article Source Type: research

An iterative approach to respiratory self-navigated whole-heart coronary MRA significantly improves image quality in a preliminary patient study.
CONCLUSION: An iterative approach to respiratory motion correction in self-navigation may lead to significant improvements in coronary MRA image quality in patients with a less consistent end-expiratory respiratory phase. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. PMID: 25960337 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 8, 2015 Category: Radiology Authors: Ginami G, Bonanno G, Schwitter J, Stuber M, Piccini D Tags: Magn Reson Med Source Type: research

Sensing and surviving hypoxia in vertebrates
Surviving hypoxia is one of the most critical challenges faced by vertebrates. Most species have adapted to changing levels of oxygen in their environment with specialized organs that sense hypoxia, while only few have been uniquely adapted to survive prolonged periods of anoxia. The goal of this review is to present the most recent research on oxygen sensing, adaptation to hypoxia, and mechanisms of anoxia tolerance in nonmammalian vertebrates. We discuss the respiratory structures in fish, including the skin, gills, and air‐breathing organs, and recent evidence for chemosensory neuroepithelial cells (NECs) in these tis...
Source: Annals of the New York Academy of Sciences - May 8, 2015 Category: Science Authors: Michael G. Jonz, Leslie T. Buck, Steve F. Perry, Thorsten Schwerte, Giacomo Zaccone Tags: Original Article Source Type: research

The fibroblast growth factor-2 arrests sp growth and immunomodulates host response in macrophages
In this study, using M. avium infection of macrophages as a model, we systematically studied the effect of fibroblast growth factor-2 (FGF-2) on M. avium infection of macrophages. Our results showed that M. avium infection could increase FGF-2 expression on both mRNA and protein levels. (Source: Tuberculosis)
Source: Tuberculosis - May 8, 2015 Category: Respiratory Medicine Authors: Jianjun Wang, Zeyou Wang, Yongliang Yao, Jianhong Wu, Xin Tang, Tao Gu, Guangxin Li Tags: Non-tuberculous mycobacteria: General Source Type: research

Incidences and outcomes of status epilepticus: A 9-year longitudinal national study.
CONCLUSIONS: Factors associated with poor outcome in admitted patients with SE by the national data were age, gender, hospital level, comorbid conditions, complications of SE, and procedural intervention. This article is part of a Special Issue entitled "Status Epilepticus". PMID: 25962656 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - May 8, 2015 Category: Neurology Authors: Tiamkao S, Pranboon S, Thepsuthammarat K, Sawanyawisuth K Tags: Epilepsy Behav Source Type: research

Estrogen amelioration of Aβ-induced defects in mitochondria is mediated by mitochondrial signaling pathway involving ERβ, AKAP and Drp1.
Abstract Perturbations in dynamic properties of mitochondria including fission, fusion, and movement lead to disruption of energy supply to synapses contributing to neuropathology and cognitive dysfunction in Alzheimer's disease (AD). The molecular mechanisms underlying these defects are still unclear. Previously, we have shown that ERβ is localized in the mitochondria and ERβ knock down disrupts mitochondrial functions. Because a selective ERβ modulator (DPN) can activate PKA, and localized PKA signaling in the mitochondrial membrane regulates mitochondrial structure and functions, we reasoned that ERβ signali...
Source: Brain Research - May 8, 2015 Category: Neurology Authors: Sarkar S, Jun S, Simpkins JW Tags: Brain Res Source Type: research

Thresholds in Chemical Respiratory Sensitisation.
Abstract There is a continuing interest in determining whether it is possible to identify thresholds for chemical allergy. Here allergic sensitisation of the respiratory tract by chemicals is considered in this context. This is an important occupational health problem, being associated with rhinitis and asthma, and in addition provides toxicologists and risk assessors with a number of challenges. In common with all forms of allergic disease chemical respiratory allergy develops in two phases. In the first (induction) phase exposure to a chemical allergen (by an appropriate route of exposure) causes immunological pr...
Source: Toxicology - May 8, 2015 Category: Toxicology Authors: Cochrane SA, Arts JH, Ehnes C, Hindle S, Hollnagel HM, Poole A, Suto H, Kimber I Tags: Toxicology Source Type: research

An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice.
Abstract Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. To clarify the potential for an anti-G mAb, 131-2G which has both anti-viral and anti-inflammatory effects, to effectively treat RSV disease, we determined the kinetics of its effect compared to the effect of the anti-F mAb, 143-6C on disease in mice. Treatment administered three days after RSV rA2-line19F (r19F) infection showed 131-2G decreased breathing effort, pulmonary m...
Source: Virology - May 8, 2015 Category: Virology Authors: Boyoglu-Barnum S, Todd SO, Chirkova T, Barnum TR, Gaston KA, Haynes LM, Tripp RA, Moore ML, Anderson LJ Tags: Virology Source Type: research

Proteomic analysis reveals down-regulation of surfactant protein B in murine type II pneumocytes infected with influenza A virus.
Abstract Infection of type II alveolar epithelial (ATII) cells by influenza A viruses (IAV) correlates with severe respiratory disease in humans and mice. To understand pathogenic mechanisms during IAV infection of ATII cells, murine ATII cells were cultured to maintain a differentiated phenotype, infected with IAV-PR8, which causes severe lung pathology in mice, and proteomics analyses were performed using liquid chromatography-mass spectrometry. PR8 infection increased levels of proteins involved in interferon signaling, antigen presentation, and cytoskeleton regulation. Proteins involved in mitochondrial membran...
Source: Virology - May 8, 2015 Category: Virology Authors: Kebaabetswe LP, Haick AK, Gritsenko MA, Fillmore TL, Chu RK, Purvine SO, Webb-Robertson BJ, Matzke MM, Smith RD, Waters KM, Metz TO, Miura TA Tags: Virology Source Type: research

Incidence and Risk Factors for Delirium among Mechanically Ventilated Patients in an African Intensive Care Setting: An Observational Multicenter Study.
Conclusion. The prevalence of delirium in a young African population is lower than expected considering the high mortality. A history of mental illness, anaemia, sedation, endotracheal tube use, and respiratory acidosis were factors associated with delirium. PMID: 25945257 [PubMed] (Source: Critical Care Research and Practice)
Source: Critical Care Research and Practice - May 7, 2015 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

Development of an Inhaled Controlled Release Voriconazole Dry Powder Formulation for the Treatment of Respiratory Fungal Infection
Molecular PharmaceuticsDOI: 10.1021/mp500808t (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - May 7, 2015 Category: Drugs & Pharmacology Authors: Sumit Arora, Mehra Haghi, Ching-Yee Loo, Daniela Traini, Paul M. Young and Sanyog Jain Source Type: research

NEWS FROM THE AAN ANNUAL MEETING: Duchenne Muscular Dystrophy: Idebenone Slows Respiratory Decline in Phase 3 Trial
No abstract available (Source: Neurology Today)
Source: Neurology Today - May 7, 2015 Category: Neurology Tags: Features Source Type: research

The potential role of vitamin D in the link between obesity and asthma severity/control in children
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - May 7, 2015 Category: Respiratory Medicine Tags: article Source Type: research