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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Enhancement of activity of tuberculosis drugs by addition of thioridazine is not reflected by improved therapeutic efficacy
Assessment of the activity of thioridazine towards Mycobacterium tuberculosis (Mtb), in vitro and in vivo as a single drug and in combination with tuberculosis (TB) drugs. (Source: Tuberculosis)
Source: Tuberculosis - October 8, 2014 Category: Respiratory Medicine Authors: Gerjo J. de Knegt, Marian T. ten Kate, Dick van Soolingen, Rob Aarnoutse, Martin J. Boeree, Irma A.J.M. Bakker-Woudenberg, Jurriaan E.M. de Steenwinkel Tags: Drug discovery and resistance Source Type: research

Clinical characteristics and airway inflammation profile of COPD persistent sputum producers
COPD patients with chronic bronchitis include a subgroup with persistent sputum production on most or every day. We hypothesized that COPD patients with persistent sputum production have a different profile of airway inflammation, and more severe clinical characteristics. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 8, 2014 Category: Respiratory Medicine Authors: S. Khurana, A. Ravi, J. Sutula, R. Milone, R. Williamson, J. Plumb, J. Vestbo, D. Singh Source Type: research

COPD care programme can reduce readmissions and in-patient bed days
Chronic obstructive pulmonary disease (COPD) is a common disease worldwide with significant morbidity and mortality. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 8, 2014 Category: Respiratory Medicine Authors: Fanny W.S. Ko, Jenny C.N. Ngai, Susanna S.S. Ng, Ka-pang Chan, Rita Cheung, Mei-yi Leung, Man-chi Pun, David S.C. Hui Source Type: research

Personalized medicine in children with asthma
Personalized medicine for children with asthma aims to provide a tailored management of asthma, which leads to faster and better asthma control, has less adverse events and may be cost saving.Several patient characteristics, lung function parameters and biomarkers have been shown useful in predicting treatment response or predicting successful reduction of asthma medication.As treatment response to the main asthma therapies is partly genetically determined, pharmacogenetics may open the way for personalized medicine in children with asthma. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 8, 2014 Category: Respiratory Medicine Authors: Mariëlle W Pijnenburg, Stanley Szefler Source Type: research

Inhaled corticosteroids in children with persistent asthma: is there a dose response impact on growth? - an overview of Cochrane reviews
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 8, 2014 Category: Respiratory Medicine Authors: Aniela I Pruteanu, Bhupendrasinh F Chauhan, Linjie Zhang, Silvio OM Prietsch, Francine M Ducharme Source Type: research

Getting to grips with ‘dysfunctional breathing’
Dysfunctional breathing is common, frequently unrecognised and responsible for a substantial burden of morbidity. Previously lack of clarity in the use of the term and the use of multiple terms to describe the same condition has hampered our understanding.DB can be defined as an alteration in the normal biomechanical patterns of breathing that result in intermittent or chronic symptoms. It can be subdivided into thoracic and extra thoracic forms. Thoracic DB is characterised by breathing patterns involving relatively inefficient, excessive upper chest wall activity with or without accessory muscle activity. (Source: Paedia...
Source: Paediatric Respiratory Reviews - October 8, 2014 Category: Respiratory Medicine Authors: Nicki Barker, Mark L Everard Source Type: research

Belhassen Tachycardia in a 19-Month-Old Child
A 19-month-old girl presented with tachycardia, at a rate of 300 beats per minute and a 2-day history of increased irritability without fever in the setting of upper respiratory infection symptoms. Her initial electrocardiogram revealed tachycardia and a mildly prolonged QRS duration (Figure). Her transthoracic echocardiogram showed normal intracardiac anatomy without a pericardial effusion. Vagal maneuvers, multiple doses of adenosine, and synchronized cardioversion were attempted without success or slowing. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 8, 2014 Category: Pediatrics Authors: Jennifer H. Huang, Sunil Saharan, Amy McCammond, Seshadri Balaji Tags: Insights and Images Source Type: research

Breathing characteristics of individuals with dentofacial deformity
Conclusion there were no differences regarding the vital capacity and pneumophonic coordination, but the dentofacial deformities group presented lower values of Maximum Phonation Time in the emissions that contain consonant phonemes. (Source: Revista CEFAC)
Source: Revista CEFAC - October 7, 2014 Category: Speech Therapy Source Type: research

'INSPIRED' COPD Outreach ProgramTM: Doing the Right Things Right.
'INSPIRED' COPD Outreach Program<sup>TM</sup>: Doing the Right Things Right. Clin Invest Med. 2014;37(5):E311 Authors: Rocker GM, Verma JY Abstract The well-documented gaps between needed and provided care for patients and families living with chronic obstructive pulmonary disease (COPD) mandate changes to clinical practice. The multifaceted evidence-based INSPIRED COPD Outreach ProgramTM was first implemented in Halifax, Nova Scotia, Canada in 2010 (INSPIRED = Implementing a Novel and Supportive Program of Individualized care for patients and families living with REspiratory Disease) and u...
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Rocker GM, Verma JY Tags: Clin Invest Med Source Type: research

New-onset Atrial Fibrillation Post-surgery for Esophageal and Junctional Cancer: Incidence, Management, and Impact on Short- and Long-term Outcomes
Conclusions: New-onset AF is common, linked to age, diabetes, cardiac disease, and neoadjuvant therapy. It is strongly associated with complications, principally respiratory sepsis, and systemic inflammation. For most, it resolves, with no impact on oncologic outcomes. (Source: Annals of Surgery)
Source: Annals of Surgery - October 7, 2014 Category: Surgery Tags: Papers of the 21st Annual ESA Meeting Source Type: research

Pertussis in the Newborn: certainties and uncertainties in 2013
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - October 7, 2014 Category: Respiratory Medicine Authors: Gustavo Rocha, Paulo Soares, Henrique Soares, Susana Pissarra, Hercília Guimarães Source Type: research

2-Tier In-Plane Motion Correction and Out-of-Plane Motion Filtering for Contrast-Enhanced Ultrasound
ConclusionThe 2-tier sequential IPMC and adaptive OPMF significantly reduced motion in 3-minute CEUS cines of FLLs, thereby overcoming the challenges of drift and irregular breathing motion in long cines. The 2-tier IPMC strategy provided stable motion correction tolerant of out-of-plane motion throughout the cine by sequentially registering subreference frames that bypassed the motion cycles, thereby overcoming the lack of a nearly stationary reference point in long cines. Out-of-plane motion filter reduced apparent motion by adaptively removing frames imaged off-plane from the automatically selected OPMF reference frame,...
Source: Investigative Radiology - October 7, 2014 Category: Radiology Tags: Original Articles Source Type: research

Clinical signs of dysphagia in infants with acute viral bronchiolitis
Conclusions: Infants with acute viral bronchiolitis displayed swallowing disorders in addition to changes in respiratory rate and measures of oxygen saturation. It is suggested, therefore, that infants displaying these risk factors have a higher probability of dysphagia. (Source: Revista Paulista de Pediatria)
Source: Revista Paulista de Pediatria - October 7, 2014 Category: Pediatrics Source Type: research

Prevalence and severity of wheezing in the first year of life in the city of Santo André, Brazil
Conclusions: In the city of Santo André, approximately half of infants had at least one episode of wheezing in the first year of life, and almost 25% had recurrent wheezing. Wheezing disorders in Santo André have early onset and high morbidity. (Source: Revista Paulista de Pediatria)
Source: Revista Paulista de Pediatria - October 7, 2014 Category: Pediatrics Source Type: research

Detection of porcine reproductive and respiratory syndrome virus in the ovary of gilts culled due to reproductive disturbances
The objective of the present study was to determine the prevalence of PRRS virus antigen by detection in the ovary of gilts culled due to reproductive disturbances. Ovarian tissues were collected from 100 Landrace x Yorkshire crossbred slaughtered gilts in Thailand. PRRS virus antigen in the ovarian tissues were detected by using immunohistochemistry. On average, the gilts were culled at 277 days of age at a body weight of 148 kg. Of these gilts, 75 had attained puberty and 25 had not attained puberty. PRRS virus antigens were detected in the macrophages within the ovary. The histological morphology of macrophages contai...
Source: Comparative Clinical Pathology - October 7, 2014 Category: Pathology Source Type: research

Prevalence and genotypes of the adenovirus infection as well detection of co-infection with bocavirus in Mexican immunosuppressed and non-immunosuppressed children with pneumonia.
CONCLUSIONS: In this 5 year analysis of samples from non-IP and IP hospitalized paediatric patients with a diagnosis of pneumonia, a low incidence of AdV was found. B1 was the most frequent subtype and frequently found in non-IP, and two cases of co-infection AdV/HBoV1 were detected in two non-IP with a influenza-like syndromes. This is the first report of HBoV and AdV co-infection in Mexico. The frequency of AdV and HBoV co-infection was lower than that reported in other populations. PMID: 25185412 [PubMed - indexed for MEDLINE] (Source: Adv Data)
Source: Adv Data - October 7, 2014 Category: Epidemiology Authors: Uribe-Gutiérrez G, Hernández-Santos H, Manjarrez-Zavala ME, Rosete-Olvera DP, Nava-Frías M, Moreno-Espinosa S, Velázquez-Guadarrama N, Gómez R, González-Márquez H, Fierro R, Mejía-Arangure JM, Zavala-Vega S, Hernández-Fernández M, Arellano-Galin Tags: Clin Lab Source Type: research

Smoking aggravates the impaired pulmonary function of officially acknowledged female victims of air pollution of 40 years ago.
In conclusion, exposure to air pollution of 40 years ago and cigarette smoking are associated with reduced pulmonary function. These results highlight the importance of measures aimed at smoking cessation and limiting air pollution. PMID: 25274138 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - October 7, 2014 Category: Research Authors: Nishinakagawa T, Senjyu H, Tanaka T, Asai M, Kotaki K, Yano Y, Miyamoto N, Yanagita Y, Kozu R, Tabusadani M, Honda S Tags: Tohoku J Exp Med Source Type: research

Oesophageal atresia with tracheo-oesophageal fistula in a preterm neonate in Limbe, Cameroon: case report & brief literature review
Conclusion: A high index of suspicion for Oesophageal atresia/trachea-oesophageal fistula should prevail when faced with a neonate with the triad: respiratory distress during feeds, regurgitation and persistent frothy salivation. The case discusses the diagnostic dilemma and management difficulties in a preterm neonate with the above association in a low income setting. (Source: BioMed Central)
Source: BioMed Central - October 7, 2014 Category: Journals (General) Authors: Leopold N AmindeVeronica N EbenyeWalters T ArreyNoah F TakahGeorge Awungafac Source Type: research

Transnasal insufflation or continuous positive airway pressure (CPAP) in acute stroke. The next step or a new dilemma?
(Source: Sleep and Breathing)
Source: Sleep and Breathing - October 7, 2014 Category: Respiratory Medicine Source Type: research

Using Cluster Analysis to Identify Phenotypes and Validation of Mortality in Men with COPD
Conclusion COPD patient with severe airflow limitation, many symptoms, and a history of frequent severe exacerbations was a novel and distinct clinical phenotype predicting mortality in men with COPD. (Source: Lung)
Source: Lung - October 7, 2014 Category: Respiratory Medicine Source Type: research

Severe alpha-1 antitrypsin deficiency in composite heterozygotes inheriting a new splicing mutation QO Madrid
Conclusion: Finding pathogenic mutations in non-coding regions of the SERPINA1 highlight the importance that regulatory regions might have in the disease. Regulatory regions should be seriously considered in discordant cases with severe AAT deficiency where no coding mutations were found. (Source: Respiratory Research)
Source: Respiratory Research - October 7, 2014 Category: Respiratory Medicine Authors: Beatriz LaraMaria MartínezIgnacio BlancoCristina Hernández-MoroEladio VelascoIlaria FerrarottiFrancisco Rodriguez-FriasLaura PerezIrene VazquezJavier AlonsoManuel PosadaBeatriz Martínez-Delgado Source Type: research

Right Ventricular Global Longitudinal Strain Is an Independent Predictor of Right Ventricular Function: A Multimodality Study of Cardiac Magnetic Resonance Imaging, Real Time Three‐Dimensional Echocardiography and Speckle Tracking Echocardiography
ConclusionRVEF and volumes estimated on RT3DE were closely correlated with CMR measurements. When compared to more traditional markers of RV systolic function and RT3DE, RVGLS produced the highest correlation with CMR RVEF and was a good predictor of RV dysfunction. RV GLS should be considered a complementary modality to RT3DE and CMR in the assessment of RV systolic function. (Source: Echocardiography)
Source: Echocardiography - October 7, 2014 Category: Cardiology Authors: Ken J. Lu, Janet X. C. Chen, Konstantinos Profitis, Leighton G. Kearney, Dimuth DeSilva, Gerard Smith, Michelle Ord, Susan Harberts, Paul Calafiore, Elizabeth Jones, Piyush M. Srivastava Tags: Original Investigation Source Type: research

Hypothyroidism associated with acromegaly and insulin‐resistant diabetes mellitus in a Samoyed
ConclusionsTo the authors' knowledge, this is the first reported case that suggests that GH alterations may have clinical significance in naturally occurring hypothyroidism. Among other factors, hypothyroidism‐induced GH excess should be considered as a possible cause of IR in patients suffering from hypothyroidism and concurrent DM. In such cases, DM may reverse with treatment of hypothyroidism, as was documented in this case. (Source: Australian Veterinary Journal)
Source: Australian Veterinary Journal - October 7, 2014 Category: Veterinary Research Authors: T Johnstone, E Terzo, CT Mooney Tags: CASE REPORT AND CLINICAL REVIEW Source Type: research

What has research over the past two decades revealed about the adverse health effects of recreational cannabis use?
ConclusionsThe epidemiological literature in the past 20 years shows that cannabis use increases the risk of accidents and can produce dependence, and that there are consistent associations between regular cannabis use and poor psychosocial outcomes and mental health in adulthood. (Source: Addiction)
Source: Addiction - October 7, 2014 Category: Addiction Authors: Wayne Hall Tags: Monograph Source Type: research

Structural and functional analysis of the fibronectin binding protein FNE from Streptococcus equi subsp. equi
This article is protected by copyright. All rights reserved. Structured digital abstractGBD and FNE bind by isothermal titration calorimetry (View interaction)GBD 789FI and FNE bind by isothermal titration calorimetry (View interaction)FNE-CT and GBD 789FI bind by isothermal titration calorimetry (View interaction)GBD and FNE-CT bind by isothermal titration calorimetry (View interaction).FNE and GBD 789FI bind by molecular sieving (View interaction)FNE-CT binds to GBD 789FI by pull down (View interaction)FNE and GBD 789FI bind by x ray scattering (View interaction)GBD and FNE physically interact by fluorescence polarizatio...
Source: FEBS Journal - October 7, 2014 Category: Research Authors: Mounira Tiouajni, Dominique Durand, Karine Blondeau, Marc Graille, Agathe Urvoas, Marielle Valerio‐Lepiniec, Asma Guellouz, Magali Aumont‐Nicaise, Philippe Minard, Herman Tilbeurgh Tags: Original Article Source Type: research

Measuring respiratory symptoms of COPD: performance of the EXACT- Respiratory Symptoms Tool (E-RS) in three clinical trials
This study examined the performance of the E-RS in each of 3 controlled trials with common and unique validation variables: one 6-month (N?=?235, US) and two 3-month (N?=?749; N?=?597; international). Subjects completed the E-RS as part of a daily eDiary. Tests of reliability, validity, and responsiveness were conducted in each dataset. Results: In each study, RS-Total score was internally consistent (Cronbach ?) (0.88, 0.92, 0.92) and reproducible (intra-class correlation) in stable patients (2?days apart: 0.91; 7?days apart: 0.71, 0.74). RS-Total scores correlated significantly with the following criterion variables (Spe...
Source: Respiratory Research - October 7, 2014 Category: Respiratory Medicine Authors: Nancy LeidyLindsey MurrayBrigitta MonzLinda NelsenMitchell GoldmanPaul JonesElizabeth DansieSanjay Sethi Source Type: research

Effects of Partial Inhibition of Respiratory Complex I on H2O 2 Production by Isolated Brain Mitochondria in Different Respiratory States.
Abstract The aim of this work was to characterize the effects of partial inhibition of respiratory complex I by rotenone on H2O2 production by isolated rat brain mitochondria in different respiratory states. Flow cytometric analysis of membrane potential in isolated mitochondria indicated that rotenone leads to uniform respiratory inhibition when added to a suspension of mitochondria. When mitochondria were incubated in the presence of a low concentration of rotenone (10 nm) and NADH-linked substrates, oxygen consumption was reduced from 45.9 ± 1.0 to 26.4 ± 2.6 nmol O2 mg(-1) min(-1) and from 7.8 ± 0....
Source: Neurochemical Research - October 7, 2014 Category: Neuroscience Authors: Michelini LG, Benevento CE, Rossato FA, Siqueira-Santos ES, Castilho RF Tags: Neurochem Res Source Type: research

Prick testing with chemicals in the diagnosis of occupational contact urticaria and respiratory diseases
ConclusionPrick tests can be safely used for diagnosing contact urticaria, asthma and rhinitis caused by isocyanates, chloramine‐T, persulfates, and chlorhexidine, but the results should be carefully interpreted and related to clinical symptoms and other diagnostic tests. (Source: Contact Dermatitis)
Source: Contact Dermatitis - October 7, 2014 Category: Dermatology Authors: Eva Helaskoski, Hille Suojalehto, Outi Kuuliala, Kristiina Aalto‐Korte Tags: Original Article Source Type: research

Interleukin-26 in Antibacterial Host Defense of Human Lungs: Effects on Neutrophil Mobilization.
Conclusion: This study implies that alveolar macrophages produce IL-26 that stimulates receptors on neutrophils and focuses their mobilization towards bacteria and accumulated immune cells in human lungs. PMID: 25291379 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 7, 2014 Category: Respiratory Medicine Authors: Che KF, Tengvall S, Levänen B, Silverpil E, Smith ME, Awad M, Vikström M, Palmberg L, Qvarfordt I, Sköld M, Lindén A Tags: Am J Respir Crit Care Med Source Type: research

Gastric Supply Manipulation to Modulate Ghrelin Production and Enhance Vascularization to the Cardia: Proof of the Concept in a Porcine Model.
Conclusions. Manipulation of the gastric flow targeting the gastroepiploic arcade induces ghrelin reduction. An endovascular approach is currently under evaluation. PMID: 25294792 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - October 7, 2014 Category: Surgery Authors: Diana M, Halvax P, Pop R, Schlagowski I, Bour G, Liu YY, Legner A, Diemunsch P, Geny B, Dallemagne B, Beaujeux R, Demartines N, Marescaux J Tags: Surg Innov Source Type: research

Transumbilical Thoracoscopy Versus Conventional Thoracoscopy for Lung Wedge Resection: Safety and Efficacy in a Live Canine Model.
Conclusions. This study suggests that both approaches for performing lung wedge resection were comparable in efficacy and postoperative complications. PMID: 25294791 [PubMed - as supplied by publisher] (Source: Surgical Innovation)
Source: Surgical Innovation - October 7, 2014 Category: Surgery Authors: Chen TP, Yen-Chu, Wu YC, Yeh CJ, Liu CY, Hsieh MJ, Yuan HC, Ko PJ, Liu YH Tags: Surg Innov Source Type: research

Pulmonary arterial hypertension in congenital heart defects with left-to-right shunt.
PMID: 25304101 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Martínez-Quintana E, Rodríguez-González F Tags: Arch Bronconeumol Source Type: research

Differences in clinical features of two immigrant populations with tuberculosis.
Abstract A study was performed to assess differences in the clinical presentation of tuberculosis between two groups of immigrants. Ninety-four patients seen in the emergency room for newly diagnosed tuberculosis between 2006 and 2012 were included. Forty-nine patients were from Asian countries and 45 from Latin America. Mean age [years (SD)] was 35.3 (13) in Asian patients and 33.9 (10) in Latin American patients. Asian subjects were predominantly male (40/49 vs 25/45; P=0.006). Patients from Latin American countries had a higher rate of pulmonary tuberculosis. A higher percentage of Asian patients lived in overcr...
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Supervía Caparrós A, Pallàs Villaronga O, Piccari L, Herrera Fernández S, Domínguez Álvarez M, Cirera Lorenzo I, Del Baño López F Tags: Arch Bronconeumol Source Type: research

Chronic thromboembolic pulmonary hypertension: Experience improves outcomes.
PMID: 25304099 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 7, 2014 Category: Respiratory Medicine Authors: Jiménez D, Zamorano JL Tags: Arch Bronconeumol Source Type: research

Serial Intervals of Respiratory Infectious Diseases: A Systematic Review and Analysis.
Abstract The serial interval of an infectious disease represents the duration between symptom onset of a primary case and symptom onset of its secondary cases. A good evidence base for such values is essential, because they allow investigators to identify epidemiologic links between cases and serve as an important parameter in epidemic transmission models used to design infection control strategies. We reviewed the literature for available data sets containing serial intervals and for reported values of serial intervals. We were able to collect data on outbreaks within households, which we reanalyzed to infer a mea...
Source: Am J Epidemiol - October 7, 2014 Category: Epidemiology Authors: Vink MA, Bootsma MC, Wallinga J Tags: Am J Epidemiol Source Type: research

Oral intake of Lactobacillus rhamnosus M21 enhances the survival rate of mice lethally infected with influenza virus.
CONCLUSION: These results demonstrate that orally administered L. rhamnosus M21 activates humoral as well as cellular immune responses, conferring increased resistance to the host against influenza virus infection. PMID: 25304268 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - October 7, 2014 Category: Microbiology Authors: Song JA, Kim HJ, Hong SK, Lee DH, Lee SW, Song CS, Kim KT, Choi IS, Lee JB, Park SY Tags: J Microbiol Immunol Infect Source Type: research

Btk-dependent epithelial cell rearrangements contribute to the invagination of nearby tubular structures in the posterior spiracles of Drosophila.
Abstract The Drosophila respiratory system consists of two connected organs, the tracheae and the spiracles. Together they ensure the efficient delivery of air-borne oxygen to all tissues. The posterior spiracles consist internally of the spiracular chamber, an invaginated tube with filtering properties that connects the main tracheal branch to the environment, and externally of the stigmatophore, an extensible epidermal structure that covers the spiracular chamber. The primordia of both components are first specified in the plane of the epidermis and subsequently the spiracular chamber is internalized through the ...
Source: Developmental Biology - October 7, 2014 Category: Biology Authors: Tsikala G, Karagogeos D, Strigini M Tags: Dev Biol Source Type: research

Role of phosphatidylinositol-3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) signaling pathways in porcine reproductive and respiratory syndrome virus (PRRSV) replication.
Abstract Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) is a positive sense, single-stranded RNA genome virus that has become a major infection in swine, exerting huge economic losses to the industry worldwide. Detailed knowledge concerning the molecular mechanisms by which the virus manipulates the host cell signal transduction machinery is not only critical to further our understanding of viral replication and pathogenesis, but also guides our efforts to design new and improved therapeutic strategies. The phosphatidylinositol-3-kinase (PI3K)-dependent Akt and the mammalian target of rapamycin (mTOR) ...
Source: Virus Research - October 7, 2014 Category: Virology Authors: Pujhari S, Kryworuchko M, Zakhartchouk AN Tags: Virus Res Source Type: research

Reprint of: Perinatal and early childhood environmental factors influencing allergic asthma immunopathogenesis.
DISCUSSION: Early life exposure to allergens (house dust mite (HDM), furred pets, cockroach, rodent and mold), air pollution (nitrogen dioxide (NO2), ozone (O3), volatile organic compounds (VOCs), and particulate matter (PM)) and viral respiratory tract infections (Respiratory syncytial virus (RSV) and human rhinovirus (hRV)) has been implicated in the development of asthma in high risk children. Conversely, exposure to microbial diversity in the perinatal period may diminish the development of atopy and asthma symptoms. PMID: 25308874 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - October 7, 2014 Category: Allergy & Immunology Authors: Gaffin JM, Kanchongkittiphon W, Phipatanakul W Tags: Int Immunopharmacol Source Type: research

Soluble factors from colonic epithelial cells contribute to gut homeostasis by modulating macrophage phenotype.
In this study we examined the role of epithelial cells in inducing this intestinal macrophage phenotype. Using an in vitro system we showed that, in two-dimensional culture, epithelial cell-derived factors from a murine cell line, CMT-93, are sufficient to induce phenotypic changes in macrophages. Exposure of monocyte-derived macrophages, J774A.1, to soluble factors derived from epithelial cells, induced an altered phenotype similar to that of intestinal macrophages with decreased production of IL-12p40, IL-6 and IL-23 and expression of MHC ІІ and CD80 following TLR ligation. Furthermore, these conditioned macrophages s...
Source: Innate Immunity - October 7, 2014 Category: Allergy & Immunology Authors: Kristek M, Collins LE, DeCourcey J, McEvoy FA, Loscher CE Tags: Innate Immun Source Type: research