Respiratory Medicine research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog.Subscribe to this data using Feedly.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.
Clinical Reasoning: An unusual cause of transverse myelitis?
A 71-year-old woman presented with a 1-week history of progressive weakness involving her lower extremities, leading to an inability to walk. She also noticed diminished sensation in her lower extremities. She did not complain of bowel or bladder dysfunction. She did not have any neurologic symptoms in her upper extremities. She experienced an upper respiratory tract infection 5 days prior to the start of these symptoms and was treated with antibiotics. There was no history of headache, impaired cognition, or speech impairment. (Source: Neurology)
Source: Neurology - February 10, 2014 Category: Neurology Authors: Bhargava, P., Elble, R. J. Tags: Metastatic tumor, Devic's syndrome, Transverse myelitis RESIDENT AND FELLOW SECTION Source Type: research
Genotype-phenotype correlations in alternating hemiplegia of childhood
Conclusions: The Glu815Lys genotype appears to be associated with the most severe AHC phenotype. Although AHC is not generally seen as a progressive disorder, it should be considered a disorder that deteriorates abruptly or in a stepwise fashion, particularly in patients with the Glu815Lys mutation. (Source: Neurology)
Source: Neurology - February 10, 2014 Category: Neurology Authors: Sasaki, M., Ishii, A., Saito, Y., Morisada, N., Iijima, K., Takada, S., Araki, A., Tanabe, Y., Arai, H., Yamashita, S., Ohashi, T., Oda, Y., Ichiseki, H., Hirabayashi, S., Yasuhara, A., Kawawaki, H., Kimura, S., Shimono, M., Narumiya, S., Suzuki, M., Yosh Tags: ARTICLE Source Type: research
Performance enhancement of respiratory tumor motion prediction using adaptive support vector regression: Comparison with adaptive neural network method
In this study, the use of a prediction algorithm with adaptive support vector regression (aSVR) was proposed and compared with the adaptive neural network (ANN) algorithm considering the prediction accuracy and training and predicting time. Respiration data from 87 patients treated by radiation therapy, were acquired with an optical marker at 30 Hz. Five types of prediction filters with the ANN or aSVR filters, were implemented and their performance was compared according to the size of the sliding window (2.5 and 5.0 sec), and the prediction latencies (100, 200, 300, 400, and 500 msec). Training and testing of the predict...
Source: International Journal of Imaging Systems and Technology - February 10, 2014 Category: Radiology Authors: SeungWook Choi, Yongjun Chang, Namkug Kim, Sung Ho Park, Si Yeol Song, Heung Sik Kang Tags: Research Article Source Type: research
Influence of age on manifestation, VC and TLCO values, and bronchoalveolar lavage cell counts of sarcoidosis and extrinsic allergic alveolitis
ConclusionsPresented results may support the hypothesis that reactivity of immune system changes during the life, which may result in different manifestation of interstitial lung diseases according to age. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 10, 2014 Category: Respiratory Medicine Authors: Martina Sterclova, Peter Paluch, Jelena Skibova, Martina Vasakova Tags: Original Article Source Type: research
The assessment and management of chronic cough in children according to the British Thoracic Society guidelines: descriptive, prospective, clinical trial
ConclusionsPostnasal drip syndrome and asthma was the most common cause of chronic cough. Asthma‐associated findings were found in some of the patients diagnosed with postnasal drip syndrome. It has been observed that there could be more than one particular cause for cough concerning some patients. The gastroesophageal reflux disease was not a common primary cause of chronic cough in children. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 10, 2014 Category: Respiratory Medicine Authors: Belgin Usta Guc, Suna Asilsoy, Cemile Durmaz Tags: Original Article Source Type: research
Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
CONCLUSIONS: We were unable to identify any randomised controlled trials or quasi-randomised controlled trials on the efficacy of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis. The absence of high level evidence for the effectiveness of these interventions emphasises the need for well-designed, adequately powered, randomised controlled clinical trials. PMID: 24515341 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 10, 2014 Category: Journals (General) Authors: Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW Tags: Cochrane Database Syst Rev Source Type: research
Elective birth at 37 weeks' gestation for women with an uncomplicated twin pregnancy.
CONCLUSIONS: Early birth at 37 weeks' gestation compared with ongoing expectant management for women with an uncomplicated twin pregnancy does not appear to be associated with an increased risk of harms, findings which are consistent with the United Kingdom's National Institute for Health and Care Excellence (NICE) recommendations which advocate birth for women with a dichorionic twin pregnancy at 37 + 0 weeks' gestation. It is unlikely that sufficient clinical equipoise exists to allow for the randomisation of women to a later gestational age at birth. PMID: 24510739 [PubMed - as supplied by publisher] (Source: Cochra...
Source: Cochrane Database of Systematic Reviews - February 10, 2014 Category: Journals (General) Authors: Dodd JM, Deussen AR, Grivell RM, Crowther CA Tags: Cochrane Database Syst Rev Source Type: research
How Outcomes are Defined in Clinical Trials of Mechanically Ventilated Adults and Children.
We present data highlighting the variability of the most commonly reported ventilation outcome definitions. Ventilation outcomes reported in trials over the last six years typically fall into four domains: measures of ventilator dependence; adverse outcomes; mortality; and resource utilization. We highlight the need first, for agreement on outcome definitions and second, for a minimum core outcome set for trials involving mechanical ventilation. A minimum core outcome set would not restrict trialists from measuring additional outcomes, but would overcome problems of variability in outcome selection, measurement and reporti...
Source: American Journal of Respiratory and Critical Care Medicine - February 10, 2014 Category: Respiratory Medicine Authors: Blackwood B, Clarke M, McAuley DF, McGuigan PJ, Marshall JC, Rose L Tags: Am J Respir Crit Care Med Source Type: research
'Theirs but to die and do' - Primary lysis of eosinophils and free eosinophil granules (FEGs) in asthma.
Abstract not applicable. PMID: 24512466 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 10, 2014 Category: Respiratory Medicine Authors: Persson C, Uller L Tags: Am J Respir Crit Care Med Source Type: research
High ICU admission rate for 2013-2014 Influenza is associated with a low rate of vaccination.
PMID: 24512430 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 10, 2014 Category: Respiratory Medicine Authors: Catania J, Que LG, Govert JA, Hollingsworth JW, Wolfe CR Tags: Am J Respir Crit Care Med Source Type: research
Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy.
This article is part of a Special Issue entitled: Membrane structure and function: Relevance in the cell's physiology, pathology and therapy. PMID: 24525076 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - February 10, 2014 Category: Biochemistry Authors: López-Rodriguez E, Pérez-Gil J Tags: Biochim Biophys Acta Source Type: research
Ornithinibacillus halotolerans sp. nov., isolated from a saline soil.
Abstract A Gram-staining-positive, aerobic, motile, endospore-forming, rod-shaped bacterium, designated GD04(T), was isolated from a saline soil sample taken in South China and was characterized by means of a polyphasic approach. Growth occurred with 0.5-12% (w/v) NaCl (optimum 1-2%) and at pH 7.0-9.5 (optimum pH 8.0) and 10-45 °C (optimum 30 °C). According to the results of phylogenetic analysis, strain GD04(T) belonged to the genus Ornithinibacillus, and was related most closely to the type strains of species Ornithinibacillus bavariensis and Ornithinibacillus contaminans (96.5 and 96.5% 16S rRNA gene sequence ...
Source: International Journal of Systematic and Evolutionary Microbiology - February 10, 2014 Category: Microbiology Authors: Lu Q, Yang G, Ma C, Qin D, Li D, Zhou S Tags: Int J Syst Evol Microbiol Source Type: research
Suppression of innate antiviral response by severe acute respiratory syndrome coronavirus M protein is mediated through the first transmembrane domain.
In this study, we demonstrate that the IFN-antagonizing activity is specific to SARS coronavirus M protein and is mediated through its first transmembrane domain (TM1) located at the N terminus. M protein from human coronavirus HKU1 does not inhibit IFN production. Whereas N-linked glycosylation of SARS coronavirus M protein has no influence on IFN antagonism, TM1 is indispensable for the suppression of IFN production. TM1 targets SARS coronavirus M protein and heterologous proteins to the Golgi apparatus, yet Golgi localization is required but not sufficient for IFN antagonism. Mechanistically, TM1 is capable of binding w...
Source: Cellular and Molecular Immunology - February 10, 2014 Category: Molecular Biology Authors: Siu KL, Chan CP, Kok KH, Chiu-Yat Woo P, Jin DY Tags: Cell Mol Immunol Source Type: research
Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitors.
In this study, we have characterized key bioenergetic properties of human sarcoma cells in order to identify metabolic vulnerabilities between sarcoma subtypes. We have also investigated the effects of compounds that inhibit glycolysis or mitochondrial respiration, either alone or in combination, and examined relationships between bioenergetic parameters and sensitivity to metabolic inhibitors. Using 2-deoxy-D-glucose (2-DG), a competitive inhibitor of glycolysis, oligomycin, an inhibitor of mitochondrial ATP synthase, and metformin, a widely-used anti-diabetes drug and inhibitor of complex I of the mitochondrial respirato...
Source: Cell Cycle - February 10, 2014 Category: Cytology Authors: Issaq SH, Teicher BA, Monks A Tags: Cell Cycle Source Type: research
Outcome of gastro-oesophageal reflux-related respiratory manifestations after laparoscopic fundoplication
Conclusion: LFP is effective with the response rates over 75% in the control of respiratory manifestation of GORD, compared to over 91% response rate in the control GOR symptoms alone. More research is needed to identify factors to aid patient selection to improve response rate. (Source: International Journal of Surgery)
Source: International Journal of Surgery - February 10, 2014 Category: Surgery Authors: Franklin Adaba, Chin W. Ang, Anthony Perry, Martin S. Wadley, Charles S. Robertson Tags: Original Research Source Type: research
Simulation of dosimetric consequences of 4D-CT-based motion margin estimation for proton radiotherapy using patient tumor motion data.
Abstract For the radiation treatment of lung cancer patients, four-dimensional computed tomography (4D-CT) is a common practice used clinically to image tumor motion and subsequently determine the internal target volume (ITV) from the maximum intensity projection (MIP) images. ITV, which is derived from short pre-treatment 4D-CT scan (<6 s per couch position), may not adequately cover the extent of tumor motion during the treatment, particularly for patients that exhibit a large respiratory variability. Inaccurate tumor localization may result in under-dosage of the tumor or over-dosage of the surrounding tissu...
Source: Physics in Medicine and Biology - February 9, 2014 Category: Physics Authors: Koybasi O, Mishra P, St James S, Lewis JH, Seco J Tags: Phys Med Biol Source Type: research
Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction
Conclusions: Hypercapnia partly protects the diaphragm against adverse effects of mechanical ventilation. (Source: Critical Care)
Source: Critical Care - February 9, 2014 Category: Intensive Care Authors: Willem-Jan SchellekensHieronymus van HeesMatthijs KoxMarianne LinkelsGilberto AcuñaPN DekhuijzenGert SchefferJohannes van der HoevenLeo Heunks Source Type: research
Cardio-respiratory and subjective strains sustained by paraplegic subjects, when travelling on a cross slope in a manual wheelchair (MWC).
Abstract The aim of this study was to quantify cardiac, energetic and subjective strains during manual wheelchair (MWC) travel on cross slopes (Cs). 25 paraplegics achieved eight 300 m propulsion tests combining 4 Cs (0, 2, 8 and 12%) and 2 velocities (Vi = 0.97 m s(-1), Vc "comfortable"). Heart rate and oxygen uptake were recorded continuously. Subjective rating (RPE) was made on completion of each test. Vc exceeds Vi for all Cs. Cardiac and energetic strains at Vc also exceed those at Vi (p < 0.01). Mean cardiac cost (in bpm) at Vc is 34 (SD = 13) bpm for a 0/2% Cs and 55 (18) bpm for a 12% Cs. Mean e...
Source: Applied Ergonomics - February 9, 2014 Category: Occupational Health Authors: Pierret B, Desbrosses K, Paysant J, Meyer JP Tags: Appl Ergon Source Type: research
Note: Page numbers of article titles are in boldface type. AATD. See Alpha1-antitrypsin deficiency (AATD) (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Source Type: research
Noninvasive Ventilation and Lung Volume Reduction
As parenchymal lung disease in chronic obstructive pulmonary disease becomes increasingly severe there is a diminishing prospect of drug therapies conferring clinically useful benefit. Lung volume reduction surgery is effective in patients with heterogenous upper zone emphysema and reduced exercise tolerance, and is probably underused. Rapid progress is being made in nonsurgical approaches to lung volume reduction, but use outside specialized centers cannot be recommended presently. Noninvasive ventilation given to patients with acute hypercapnic exacerbation of chronic obstructive pulmonary disease reduces mortality and m...
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Patrick Brian Murphy, Zaid Zoumot, Michael Iain Polkey Source Type: research
Acute COPD Exacerbations
Exacerbations are important events for patients with chronic obstructive pulmonary disease (COPD) and key outcomes in COPD studies and trials. Exacerbations have an impact on health status and contribute to disease progression, and exacerbation prevention is a key goal of therapy in COPD. A majority of COPD exacerbations are triggered by respiratory viral infections and/or bacterial infections. Several pharmacologic therapies can prevent COPD exacerbations and reduce hospital admissions. Nonpharmacologic interventions for exacerbation prevention include pulmonary rehabilitation, long-term oxygen therapy, and home noninvasi...
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Jadwiga A. Wedzicha, Richa Singh, Alex J. Mackay Source Type: research
Cigarette smoking is a major preventable cause of morbidity and mortality. It is the major risk factor for chronic obstructive pulmonary disease in the developed world. Smoking is a chronic relapsing disease. Optimal treatment includes nonpharmacologic support, together with pharmacotherapy. All clinicians should be comfortable with the use of nicotine replacement therapy, bupropion, and varenicline. Second-line therapies can be used by those familiar with their use. Effective use of these medications requires their integration into an effective management plan, which is likely to be a long-term undertaking, involving seve...
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Stephen I. Rennard, David M. Daughton Source Type: research
Current Drug Treatment, Chronic and Acute
This article reviews the key components of the pharmacologic treatment of COPD, both acute and chronic, with an emphasis on those recent studies, which are likely to change practice in the next few years. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Peter Calverley Source Type: research
Role of Infections
This article represents a review of the current literature on the role of infection in the pathogenesis of chronic obstructive pulmonary disease (COPD), in stable disease, exacerbations, and pneumonia. It outlines the complex interactions between respiratory pathogens and host immune defenses that underlie the clinical manifestations of infection in COPD. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Kamen Rangelov, Sanjay Sethi Source Type: research
Comorbidities and Systemic Effects of Chronic Obstructive Pulmonary Disease
Although primarily a lung disease, chronic obstructive pulmonary disease (COPD) is now recognized to have extrapulmonary effects on distal organs, the so-called systemic effects and comorbidities of COPD. Skeletal muscle dysfunction, nutritional abnormalities including weight loss, cardiovascular complications, metabolic complications, and osteoporosis, among others, are all well-recognized associations in COPD. These extrapulmonary effects add to the burden of mortality and morbidity in COPD and therefore should be actively looked for, assessed, and treated. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Gourab Choudhury, Roberto Rabinovich, William MacNee Source Type: research
Epidemiology and Prevalence of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) represents one of the main causes of morbidity and mortality worldwide. According to the World Health Organization, approximately 3 million people in the world die as a consequence of COPD every year. Tobacco use remains the main factor associated with development of disease in the industrialized world, but other risk factors are important and preventable causes of COPD, particularly in the developing world. The purpose of this review is to summarize the literature on the subject and to provide an update of the most recent advances in the field. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Authors: Enrique Diaz-Guzman, David M. Mannino Source Type: research
Pulmonary Rehabilitation Linda Nici, MD and Richard ZuWallack, MD, Editors (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Source Type: research
PETER J. BARNES, FRS, FMedSci Head of Respiratory Medicine, National Heart and Lung Institute, Imperial College, London, United Kingdom (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - February 8, 2014 Category: Respiratory Medicine Source Type: research
Nursing diagnoses in patients classified as priority level I and II according to the Manchester protocol
This study suggests that the use of the Manchester protocol enabled identification of defining characteristics and risk factors and supports the elaboration of nursing diagnoses in risk classification. (Source: Revista da Escola de Enfermagem da USP)
Source: Revista da Escola de Enfermagem da USP - February 8, 2014 Category: Nursing Source Type: research
Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge
Conclusion: When anti-GP5 Ab2s are present, the use of attenuated PRRSV vaccine CH-1R against HP-PRRSV infection is not recommended. It can result in poor health status with pneumonia and thymus atrophy. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 8, 2014 Category: Epidemiology Authors: Ying YuXuehui CaiGang WangNing KongYonggang LiuYihong XiaoChong ZhangYang MuShuqi XiaoQin ZhaoChengbao WangGaiping ZhangJulian A HiscoxEn-Min Zhou Source Type: research
Endoscopic treatment of Native Lung Hyperinflation using Endobronchial valves in Single Lung Transplant patients: A multinational experience
ConclusionsTreating NLH with IBV endobronchial valves leads to clinical improvement in the majority of patients and the treatment has an acceptable safety. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 8, 2014 Category: Respiratory Medicine Authors: Michael Perch, Gerdt C. Riise, Kyle Hogarth, Ali I. Musani, Steven C. Springmeyer, Xavier Gonzalez, Martin Iversen Tags: Original Article Source Type: research
Lung abscess combined with chronic osteomyelitis of the mandible successfully treated with video‐assisted thoracoscopic surgery
Abstract With the progress of antibiotic therapy, the mortality of lung abscess has been improved and surgical intervention has declined. However, surgery is still required in selected cases which are intractable to antibiotic treatment. Video‐assisted thoracoscopic surgery (VATS) is beneficial for treatment and/or diagnosis of pulmonary disease as it provides a less invasive surgical technique and reduces prolongation of post‐operative recovery. However, the indication of VATS lobectomy for lung abscess is controversial as a result of particular complications, i.e., wet lung, intrapleural adhesion, and ease of bleedin...
Source: The Clinical Respiratory Journal - February 8, 2014 Category: Respiratory Medicine Authors: Hiromasa Arai, Kenji Inui, Keisuke Watanabe, Kei Watanuki, Koji Okudela, Masahiro Tsuboi, Munetaka Masuda Tags: Case report Source Type: research
Incentive spirometry for prevention of postoperative pulmonary complications in upper abdominal surgery.
CONCLUSIONS: There is low quality evidence regarding the lack of effectiveness of incentive spirometry for prevention of postoperative pulmonary complications in patients after upper abdominal surgery. This review underlines the urgent need to conduct well-designed trials in this field. There is a case for large RCTs with high methodological rigour in order to define any benefit from the use of incentive spirometry regarding mortality. PMID: 24510642 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - February 8, 2014 Category: Journals (General) Authors: do Nascimento Junior P, Módolo NS, Andrade S, Guimarães MM, Braz LG, El Dib R Tags: Cochrane Database Syst Rev Source Type: research
Occurrence of a case of influenza A(H1N1)pdm09 and B co-infection during the epidemic season 2012-2013.
We report the detection of one case of co-infection with influenza A(H1N1)pdm09 and B, occurred during the 2012-2013 influenza season in Sicily. The dual infection was identified in a 18-year-old boy, who was not covered by specific vaccination and who had no other pre-existing risk factors. He presented classical symptoms of influenza-like illness developing no respiratory complications. A(H1N1)pdm09 viral concentration was initially about 10-fold higher than B virus, whereas its clearance was more rapidly achieved than in the case of B virus infection. Although influenza co-infection appears to be a rare event, a continu...
Source: Infection, Genetics and Evolution - February 8, 2014 Category: Genetics & Stem Cells Authors: Fabio T, Massimo MC, Francesco M, Emanuele A, Francesco V Tags: Infect Genet Evol Source Type: research
Frederiksenia canicola gen. nov., sp. nov. isolated from dogs and human dog-bite wounds.
Abstract Polyphasic analysis was done on 24 strains of Bisgaard taxon 16 from five European countries and mainly isolated from dogs and human dog-bite wounds. The isolates represented a phenotypically and genetically homogenous group within the family Pasteurellaceae. Their phenotypic profile was similar to members of the genus Pasteurella. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry clearly identified taxon 16 and separated it from all other genera of Pasteurellaceae showing a characteristic peak combination. Taxon 16 can be further separated and identified by a RecN protein signat...
Source: Antonie van Leeuwenhoek - February 8, 2014 Category: Microbiology Authors: Korczak BM, Bisgaard M, Christensen H, Kuhnert P Tags: Antonie Van Leeuwenhoek Source Type: research
Respir Care; +206 new citations
206 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Respir Care These pubmed results were generated on 2014/02/07PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Respiratory Care)
Source: Respiratory Care - February 7, 2014 Category: Respiratory Medicine Tags: Report Source Type: research
Respiratory Infections Michael J. Loeffelholz, Editor (Source: Clinics in Laboratory Medicine)
Source: Clinics in Laboratory Medicine - February 7, 2014 Category: Laboratory Medicine Source Type: research