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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Carbon dioxide in the critically ill: too much or too little of a good thing?
Abstract Hypercapnia and hypocapnia commonly complicate conditions that are present in critically ill patients. Both conditions have important physiologic effects that may impact the clinical management of these patients. For instance, hypercapnia results in bronchodilation and enhanced hypoxic vasoconstriction, leading to improved ventilation/perfusion matching. Hypocapnia reduces cerebral blood volume through arterial vasoconstriction. These effects have also been exploited for therapeutic aims. In patients with traumatic brain injury (TBI), hypocapnia is often utilized to control intracranial pressure. However, ...
Source: Respiratory Care - October 1, 2014 Category: Respiratory Medicine Authors: Marhong J, Fan E Tags: Respir Care Source Type: research

Massive left hemothorax following laparoscopic pyeloplasty
We report a case of hemothorax complicating an otherwise uneventful LP in an 18-year-old girl. (Source: Indian Journal of Urology)
Source: Indian Journal of Urology - October 1, 2014 Category: Urology & Nephrology Authors: Manjula RaoNischith D'SouzaAltaf KhanMujeebu Rahiman Source Type: research

Migration and determinants of health: clinical epidemiological characteristics of migrants in Malta (2010-11)
Conclusions Immigrants have a lower morbidity burden compared with their fellow countrymen living in the origin country. However, living conditions during the journey, in transit countries and after arrival can influence their health status. The present study provides a comprehensive picture of this growing population that is in need for health promotion, mental health services and fair policy planning. (Source: Journal of Public Health)
Source: Journal of Public Health - October 1, 2014 Category: Health Management Authors: Padovese, V., Egidi, A. M., Melillo Fenech, T., Podda Connor, M., Didero, D., Costanzo, G., Mirisola, C. Tags: Wider determinants Source Type: research

Ventilated cookstoves associated with improvements in respiratory health-related quality of life in rural Bolivia
Conclusions This is the first use of a standardized respiratory HRQoL assessment to determine the impact of ventilated cookstove implementation on reducing HAP. This preliminary study utilizes the SGRQ as a valuable tool enabling analysis of these health effects in relation to other respiratory disease states. (Source: Journal of Public Health)
Source: Journal of Public Health - October 1, 2014 Category: Health Management Authors: Alexander, D., Linnes, J. C., Bolton, S., Larson, T. Tags: Interventions (preventive) Source Type: research

Enabling patients with respiratory symptoms to access chest X-rays on demand: the experience of the walk-in service in Corby, UK
Conclusions The implementation of the service was associated with a significant increase in the numbers of clinically indicated CXRs in an area of high lung cancer incidence and mortality. The service attracted a clinically appropriate population. The numbers of cancers detected were in line with statistical expectations. (Source: Journal of Public Health)
Source: Journal of Public Health - October 1, 2014 Category: Health Management Authors: Campbell, J., Pyer, M., Rogers, S., Walter, D., Reddy, R. Tags: Interventions (services) Source Type: research

J&J to buy antiviral specialist Alios
$1.75 billion deal brings Phase II compounds for hepatitis C and respiratory syncytial virus (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - October 1, 2014 Category: Chemistry Authors: Phillip Broadwith Source Type: research

Nitrogen dioxide and ozone: a sinister synergy
New insight into the mechanisms by which nitrogen dioxide and ozone damage the human respiratory tract (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - October 1, 2014 Category: Chemistry Authors: William Bergius Source Type: research

A computational physiology approach to personalized treatment models: the beneficial effects of slow breathing on the human cardiovascular system
This study used a computational physiology approach to dynamically model the human cardiovascular system at rest and during resonance breathing. Noninvasive measurements of heart period, beat-to-beat systolic and diastolic blood pressure, and respiration period were obtained from 24 healthy young men and women. A model with respiration as input was parameterized to better understand how the cardiovascular processes that control variability in heart period and blood pressure change from rest to resonance breathing. The cost function used in model calibration corresponded to the difference between the experimental data and m...
Source: AJP: Heart and Circulatory Physiology - October 1, 2014 Category: Cardiology Authors: Fonoberova, M., Mezić, I., Buckman, J. F., Fonoberov, V. A., Mezić, A., Vaschillo, E. G., Mun, E.-Y., Vaschillo, B., Bates, M. E. Tags: INTEGRATIVE CARDIOVASCULAR PHYSIOLOGY AND PATHOPHYSIOLOGY Source Type: research

The disease-associated mutation of the mitochondrial sulphydryl oxidase Erv1 impairs cofactor binding during its catalytic reaction
In this study, we use yeast Erv1 as a model to provide clear evidence for a progressive functional defect in the catalytic activity of the corresponding Erv1 R182H mutant. We show that the FAD cofactor was released from Erv1 R182H during its catalytic cycle, which led to the inactivation of the enzyme. We also characterised the effects of the mutation on the folding and stability of Erv1, and tested our in vitro findings in vivo using a yeast genetic approach. The results of this study allows us to provide a model for the functional defect in Erv1 R182H, which could potentially be extended to human ALR R194H, and provides ...
Source: BJ Energy - October 1, 2014 Category: Biochemistry Authors: E Ceh-Pavia, S Ang, M P Spiller, H Lu Tags: BJ Biomolecules Source Type: research

Thermal plasticity of skeletal muscle mitochondrial activity and whole animal respiration in a common intertidal triplefin fish, Forsterygion lapillum (Family: Tripterygiidae)
Abstract Oxygen demand generally increases in ectotherms as temperature rises in order to sustain oxidative phosphorylation by mitochondria. The thermal plasticity of ectotherm metabolism, such as that of fishes, dictates a species survival and is of importance to understand within an era of warming climates. Within this study the whole animal O2 consumption rate of a common New Zealand intertidal triplefin fish, Forsterygion lapillum, was investigated at different acclimation temperatures (15, 18, 21, 24 or 25 °C) as a commonly used indicator of metabolic performance. In addition, the mitochondria within permea...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - October 1, 2014 Category: Physiology Source Type: research

Postexercise whole body heat stress additively enhances endurance training-induced mitochondrial adaptations in mouse skeletal muscle
A recent study demonstrated that heat stress induces mitochondrial biogenesis in C2C12 myotubes, thereby implying that heat stress may be an effective treatment to enhance endurance training-induced mitochondrial adaptations in skeletal muscle. However, whether heat stress actually induces mitochondrial adaptations in skeletal muscle in vivo is unclear. In the present study, we report the novel findings that 1) whole body heat stress produced by exposure of ICR mice to a hot environment (40°C, 30 min/day, 5 days/wk, 3 wk) induced mitochondrial adaptations such as increased mitochondrial enzyme activity (citrate synthas...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 1, 2014 Category: Physiology Authors: Tamura, Y., Matsunaga, Y., Masuda, H., Takahashi, Y., Takahashi, Y., Terada, S., Hoshino, D., Hatta, H. Tags: Physical Activity and Inactivity Source Type: research

Spinal NMDA receptor activation constrains inactivity-induced phrenic motor facilitation in Charles River Sprague-Dawley rats
Reduced spinal synaptic inputs to phrenic motor neurons elicit a unique form of spinal plasticity known as inactivity-induced phrenic motor facilitation (iPMF). iPMF requires tumor necrosis factor-α (TNF-α) and atypical protein kinase C (aPKC) activity within spinal segments containing the phrenic motor nucleus to stabilize early, transient increases in phrenic burst amplitude into long-lasting iPMF. Here we tested the hypothesis that spinal N-methyl-d-aspartate receptor (NMDAR) activation constrains long-lasting iPMF in some rat substrains. Phrenic motor output was recorded in anesthetized, ventilated Harlan (...
Source: Journal of Applied Physiology - October 1, 2014 Category: Physiology Authors: Streeter, K. A., Baker-Herman, T. L. Tags: ARTICLES Source Type: research

Lung ventilation injures areas with discrete alveolar flooding, in a surface tension-dependent fashion
With proteinaceous-liquid flooding of discrete alveoli, a model of the edema pattern in the acute respiratory distress syndrome, lung inflation over expands aerated alveoli adjacent to flooded alveoli. Theoretical considerations suggest that the overexpansion may be proportional to surface tension, T. Yet recent evidence indicates proteinaceous edema liquid may not elevate T. Thus whether the overexpansion is injurious is not known. Here, working in the isolated, perfused rat lung, we quantify fluorescence movement from the vasculature to the alveolar liquid phase as a measure of overdistension injury to the alveolar-capil...
Source: Journal of Applied Physiology - October 1, 2014 Category: Physiology Authors: Wu (吴右), Y., Kharge, A. B., Perlman, C. E. Tags: ARTICLES Source Type: research

Quantifying hypoxia-induced chemoreceptor sensitivity in the awake rodent
We evaluated several methods for characterizing hypoxic chemosensitivity in the conscious rat. Adult Sprague-Dawley rats (n = 30) were exposed to normobaric hypoxia [inspired oxygen fraction (Fio2) 0.15, 0.12, and 0.09]. We measured ventilation (Ve; barometric plethysmography), arterial oxygen saturation (SpO2; pulse oximeter), and oxygen consumption and carbon dioxide production (Vo2 and Vco2; analysis of expired air). Linear regression analysis was used to define stimulus-response relationships. Testing was performed on 2 days to assess day-to-day reproducibility. Exposure to graded, steady-state hypoxia caused progressi...
Source: Journal of Applied Physiology - October 1, 2014 Category: Physiology Authors: Morgan, B. J., Adrian, R., Bates, M. L., Dopp, J. M., Dempsey, J. A. Tags: INNOVATIVE METHODOLOGY Source Type: research

Co‐ordinating the clinical management of imported human cases suspected of being infected with a highly pathogenic virus such as Ebola
This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - October 1, 2014 Category: Microbiology Authors: Xavier Lamballerie Tags: Infection Hot Topic Source Type: research

Investigating the Link between Particulate Exposure and Airway Inflammation in the Horse
The objective of this review is to provide the reader with a summary of the most common chronic inflammatory airway diseases in the horse and the principles of air sampling that are essential to the planning, interpretation, and assessment of equine respiratory health‐related exposure studies. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 1, 2014 Category: Veterinary Research Authors: K.M. Ivester, L.L. Couëtil, N.J. Zimmerman Tags: Review Source Type: research

Home-Made Continuous Positive Airways Pressure Device may Reduce Mortality in Neonates with Respiratory Distress in Low-Resource Setting
Conclusion: A low-cost and locally assembled CPAP delivery system may reduce neonatal mortality among babies with respiratory distress. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - October 1, 2014 Category: Tropical Medicine Authors: Daga, S., Mhatre, S., Borhade, A., Khan, D. Tags: Original Papers Source Type: research

Is Continuous Positive Airway Pressure a Feasible Treatment Modality for Neonates with Respiratory Distress Syndrome in a Rural District Hospital?
Conclusions: nCPAP for neonatal respiratory distress at the district hospital is feasible, safe and offers the potential for significant cost savings. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - October 1, 2014 Category: Tropical Medicine Authors: Hendriks, H., Kirsten, G. F., Voss, M., Conradie, H. Tags: Original Papers Source Type: research

How Rhinovirus Infections Cause Exacerbations of Asthma
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - October 1, 2014 Category: Allergy & Immunology Authors: James E. Gern Tags: Invited Review Source Type: research

Increased lung inflammation with oxygen supplementation in tracheotomized spontaneously breathing rabbits: an experimental prospective randomized study
Conclusions: Oxygen supplementation in spontaneous breathing is associated with an increased inflammatory response when compared to breathing normal room air. This inflammatory response was mainly constituted with polymorphonuclear cells (eosinophils and neutrophils). As confirmed in all animals by peripheral blood analyses, the eosinophilic inflammatory response was a local organ event. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 1, 2014 Category: Anesthesiology Authors: Humberto MachadoCatarina NunesPaula SáAntonio CouceiroÁlvaro da SilvaArtur Águas Source Type: research

Current ventilation practice during general anaesthesia: a prospective audit in Melbourne, Australia
Conclusion: In mechanically ventilated patients under general anaesthesia, tidal volume was high and PEEP was applied to the majority of patients, but at modest levels. The findings of our study suggest that the control groups of previous randomized controlled trials do not closely reflect the practice of mechanical ventilation in Australia. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 1, 2014 Category: Anesthesiology Authors: Dharshi KaralapillaiLaurence WeinbergJonathan GaltieriNeil GlassfordGlenn EastwoodJai DarvallJake GeertsemaRavi BangiaJane FitzgeraldTuong PhanLuke OHallaranAdriano CoccianteStuart WatsonDavid StoryRinaldo Bellomo Source Type: research

General Health Status and Late Effects Among Adolescent and Young Adult Survivors of Childhood Cancer in Japan
Conclusions Many adolescent/young adult childhood cancer survivors could be suffering from ongoing late effects that stem from cancer and its treatment. Overall health monitoring for childhood cancer survivors can provide indispensable benefits. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2014 Category: Cancer & Oncology Authors: Ozono, S., Ishida, Y., Honda, M., Okamura, J., Asami, K., Maeda, N., Sakamoto, N., Inada, H., Iwai, T., Kamibeppu, K., Kakee, N., Horibe, K. Tags: Original Articles Pediatrics Source Type: research

A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections
Conclusions: The incidence of AC increases with age. Infections, especially bacterial infections, are associated with the incidence of ACs and this increases with age. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 1, 2014 Category: Endocrinology Authors: Rosemary RushworthDavid Torpy Source Type: research

Ventilation Practices in Subarachnoid Hemorrhage: A Cohort Study Exploring the Use of Lung Protective Ventilation
Conclusion Patients with SAH requiring mechanical ventilation frequently breathe spontaneously, generating tidal volumes above usual protective thresholds regardless of meeting ARDS criteria. In patients with SAH, the presence of an additional ARDS risk factor should prompt close screening for the development of ARDS and consideration of adjustment of ventilator settings to meet lung protective thresholds. (Source: Neurocritical Care)
Source: Neurocritical Care - October 1, 2014 Category: Neurology Source Type: research

Real-time monitoring of endogenous lipid peroxidation by exhaled ethylene in patients undergoing cardiac surgery
Pulmonary and systemic organ injury produced by oxidative stress including lipid peroxidation is a fundamental tenet of ischemia-reperfusion injury, inflammatory response to cardiac surgery, and cardiopulmonary bypass (CPB) but is not routinely measured in a surgically relevant time frame. To initiate a paradigm shift toward noninvasive and real-time monitoring of endogenous lipid peroxidation, we have explored pulmonary excretion and dynamism of exhaled breath ethylene during cardiac surgery to test the hypothesis that surgical technique and ischemia-reperfusion triggers lipid peroxidation. We have employed laser photoaco...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Cristescu, S. M., Kiss, R., te Lintel Hekkert, S., Dalby, M., Harren, F. J. M., Risby, T. H., Marczin, N., on behalf of the Harefield BIOSTRESS study investigators Tags: RAPID REPORTS Source Type: research

The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator
Premature infants requiring supplemental oxygen are at increased risk for developing bronchopulmonary dysplasia (BPD). Rodent models involving neonatal exposure to excessive oxygen concentrations (hyperoxia) have helped to identify mechanisms of BPD-associated pathology. Genome-wide assessments of the effects of hyperoxia in neonatal mouse lungs could identify novel BPD-related genes and pathways. Newborn C57BL/6 mice were exposed to 100% oxygen for 10 days, and whole lung tissue RNA was used for high-throughput, sequencing-based transcriptomic analysis (RNA-Seq). Significance Analysis of Microarrays and Ingenuity Pathway ...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Bhattacharya, S., Zhou, Z., Yee, M., Chu, C.-Y., Lopez, A. M., Lunger, V. A., Solleti, S. K., Resseguie, E., Buczynski, B., Mariani, T. J., O'Reilly, M. A. Tags: CALL FOR PAPERS Source Type: research

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury
Claudins are tight junction proteins that regulate paracellular ion permeability of epithelium and endothelium. Claudin 4 has been reported to function as a paracellular sodium barrier and is one of three major claudins expressed in lung alveolar epithelial cells (AEC). To directly assess the role of claudin 4 in regulation of alveolar epithelial barrier function and fluid homeostasis in vivo, we generated claudin 4 knockout (Cldn4 KO) mice. Unexpectedly, Cldn4 KO mice exhibited normal physiological phenotype although increased permeability to 5-carboxyfluorescein and decreased alveolar fluid clearance were noted. Cldn4 KO...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Kage, H., Flodby, P., Gao, D., Kim, Y. H., Marconett, C. N., DeMaio, L., Kim, K.-J., Crandall, E. D., Borok, Z. Tags: ARTICLES Source Type: research

PKG-1{alpha} leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension
Pulmonary hypertension (PH) is a chronic disease characterized by a progressive increase in vasomotor tone, narrowing of the vasculature with structural remodeling, and increase in pulmonary vascular resistance. Current treatment strategies include nitric oxide therapy and methods to increase cGMP-mediated vasodilatation. cGMP-dependent protein kinases (PKG) are known mediators of nitric oxide- and cGMP-induced vasodilatation. Deletion of PKG-1 in mice has been shown to induce PH, however, the exact mechanisms by which loss of PKG-1 function leads to PH is not known. In a mouse model with a selective mutation in the NH2-te...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Ramchandran, R., Raghavan, A., Geenen, D., Sun, M., Bach, L., Yang, Q., Raj, J. U. Tags: ARTICLES Source Type: research

Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats
Although hypoxia is detrimental to most cell types, it aids survival of progenitor cells and is associated with diseases like cancer and pulmonary hypertension in humans. Therefore, understanding the underlying mechanisms that promote survival of progenitor cells in hypoxia and then developing novel therapies to stop their growth in hypoxia-associated human diseases is important. Here we demonstrate that the proliferation and growth of human CD133+ progenitor cells, which contribute to tumorigenesis and the development of pulmonary hypertension, are increased when cultured under hypoxic conditions. Furthermore, glucose-6-p...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Chettimada, S., Joshi, S. R., Alzoubi, A., Gebb, S. A., McMurtry, I. F., Gupte, R., Gupte, S. A. Tags: ARTICLES Source Type: research

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-{alpha}
Remodeling in chronic obstructive pulmonary disease (COPD) has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recently we showed comparable alterations of the extracellular matrix (ECM) compounds collagen, hyaluoran, and elastin in alveolar and small airway walls of COPD patients. The aim of this study was to characterize and assess similarities in alveolar and small airway wall matrix remodeling in chronic COPD models. From this comparative characterization of matrix remodeling we derived and elaborated underlying mechanisms to the matrix changes reported in COPD. Lung tissue sect...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Eurlings, I. M. J., Dentener, M. A., Mercken, E. M., de Cabo, R., Bracke, K. R., Vernooy, J. H. J., Wouters, E. F. M., Reynaert, N. L. Tags: ARTICLES Source Type: research

{alpha}-Klotho protects against oxidative damage in pulmonary epithelia
α-Klotho exerts pleiotropic biological actions. Heterozygous α-Klotho haplo-insufficient mice (kl/+) appear normal at baseline except for age-related changes in the lung, suggesting heightened pulmonary susceptibility to α-Klotho deficiency. We used in vivo and in vitro models to test whether α-Klotho protects lung epithelia against injury. Normally, α-Klotho is not expressed in the lung, but circulating α-Klotho levels are reduced ~40% in kl/+ mice and undetectable in homozygous α-Klotho-deficient mice (kl/kl). kl/+ mice show distal air space enlargement at a given airway pressure...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Ravikumar, P., Ye, J., Zhang, J., Pinch, S. N., Hu, M. C., Kuro-o, M., Hsia, C. C. W., Moe, O. W. Tags: ARTICLES Source Type: research

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation
We previously reported that transglutaminase 2 (TG2) activity is markedly elevated in lungs of hypoxia-exposed rodent models of pulmonary hypertension (PH). Since vascular remodeling of pulmonary artery smooth muscle cells (PASMCs) is important in PH, we undertook the present study to determine whether TG2 activity is altered in PASMCs with exposure to hypoxia and whether that alteration participates in their proliferative response to hypoxia. Cultured distal bovine (b) and proximal human (h) PASMCs were exposed to hypoxia (3% O2) or normoxia (21% O2). mRNA and protein expression were determined by PCR and Western blot ana...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Penumatsa, K. C., Toksoz, D., Warburton, R. R., Hilmer, A. J., Liu, T., Khosla, C., Comhair, S. A. A., Fanburg, B. L. Tags: ARTICLES Source Type: research

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis
Excessive neutrophil activation is a major component in septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to bacterial invasions. The aim of the present study was to investigate the potential role of neutrophil extracellular traps (NETs) in septic lung injury. Male C57BL/6 mice were treated with recombinant human (rh)DNAse (5 mg/kg) after cecal ligation and puncture (CLP). Extracellular DNA was stained by Sytox green, and NET formation was quantified by confocal microscopy and cell-free DNA in plasma, peritoneal cavity, and lung. Blood, peritoneal fluid, and lung tissue were harvested for ...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Luo, L., Zhang, S., Wang, Y., Rahman, M., Syk, I., Zhang, E., Thorlacius, H. Tags: ARTICLES Source Type: research

Methionine restriction slows down senescence in human diploid fibroblasts
Summary Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex IV, but also complex I, which was due to a decreased translation rate of several mtDNA‐encoded subunits. Together, these findings indicate that M...
Source: Aging Cell - October 1, 2014 Category: Cytology Authors: Rafał Kozieł, Christoph Ruckenstuhl, Eva Albertini, Michael Neuhaus, Christine Netzberger, Maria Bust, Frank Madeo, Rudolf J. Wiesner, Pidder Jansen‐Dürr Tags: Original Article Source Type: research

Spirometric Evaluation in Juvenile Idiopathic Arthritis: Data from Eastern India
Conclusion Spirometry in JIA patients demonstrated statistically significant restrictive pattern of alteration in pulmonary function. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 1, 2014 Category: Pediatrics Source Type: research

Use of Multimodal Imaging in the Management of Tumor Embolism From the Inferior Vena Cava Through the Right Heart in a Patient With Renal Cell Carcinoma
R?>ENAL CELL CARCINOMA invades the inferior vena cava in approximately 10% of patients, with further tumor extension into the right atrium occurring in only 1%. Survival after renal cell carcinoma embolization into the pulmonary artery is unusual, but surgical resection of tumor emboli occasionally has been reported. The present report describes the management of large bilateral pulmonary tumor emboli after nephrectomy for renal cell carcinoma. Using transesophageal echocardiography (TEE), the authors directly observed large fragments break off from the patient’s inferior vena caval tumor during the nephrectomy and migra...
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 1, 2014 Category: Anesthesiology Authors: Elizabeth M. Colwell, Sweeta D. Gandhi, Zafar Iqbal, Zahir A. Rashid, Paul S. Pagel Tags: E-CHALLENGES & CLINICAL DECISIONS Source Type: research

October Highlights/Papers by Junior Investigators/NIH News.
Authors: PMID: 25275431 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - October 1, 2014 Category: Molecular Biology Tags: Am J Respir Cell Mol Biol Source Type: research

A rare association between Fabry¿s disease and granulomatosis with polyangiitis: a potential pathogenic link
Conclusion: Because both Fabry’s disease and granulomatosis with polyangiitis or crescentic glomerulonephritis are rare diseases, their concurrence in this and related cases suggests there may be a pathogenic link between these two conditions. Fabry’s disease may be underdiagnosed, particularly in cases of granulomatosis with polyangiitis or crescentic glomerulonephritis. (Source: BMC Nephrology)
Source: BMC Nephrology - October 1, 2014 Category: Urology & Nephrology Authors: Hironari HanaokaAkinori HashiguchiKonosuke KonishiTomohiro IshiiMasataka Kuwana Source Type: research

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol - Comparison with MAG3 scintigraphy.
Conclusions: The proposed protocol provides a robust technique for assessment of ureteral obstruction and split renal function with compensation of breathing artifacts, short post-processing time, and excellent 3D spatial resolution. Advances in Knowledge: The combined protocol of 2D and 3D MR urography is an efficient technique for assessment of renal morphology and function. PMID: 25270833 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 1, 2014 Category: Radiology Authors: Boss A, Martirosian P, Fuchs J, Obermayr F, Tsiflikas I, Schick F, Schäfer JF Tags: Br J Radiol Source Type: research

Feasibility of automated pancreas segmentation based on dynamic MRI.
Conclusions: We have shown the feasibility of automated segmentation of the pancreas anatomy on dynamic MRI. Advances in knowledge: Using the hybrid method improves segmentation robustness of low-contrast images. PMID: 25270713 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 1, 2014 Category: Radiology Authors: Gou S, Wu J, Liu F, Lee P, Rapacchi S, Hu P, Sheng K Tags: Br J Radiol Source Type: research

Pulmonary artery aneurysms.
PMID: 25271757 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Ataya A, Alnuaimat H Tags: Am J Respir Crit Care Med Source Type: research

Malignant uveitis masquerade syndrome.
PMID: 25271756 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Tan AH, Chee SP Tags: Am J Respir Crit Care Med Source Type: research

Erratum: club cell protein 16 and disease progression in chronic obstructive pulmonary disease.
Authors: PMID: 25271755 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply: Understanding the Roles of the Vitamin E Isoforms α- and γ-Tocopherol in Allergic Airway Disease.
PMID: 25271754 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Cook-Mills J, Hartert T Tags: Am J Respir Crit Care Med Source Type: research