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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Overlap of obstructive sleep apnea and bronchial asthma: Effect on asthma control
Conclusion A high index of suspicion is warranted for the overlap of OSA and asthma, particularly in the presence of obesity, GERD, and in patients with severe asthma. Individualized therapy addressing these moderating factors is warranted for optimal health outcomes. Recognition and treatment of OSA in asthmatics is an important element in improving asthma control. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - February 19, 2015 Category: Respiratory Medicine Source Type: research

PT-1 selectively activates AMPK-{gamma}1 complexes in mouse skeletal muscle, but activates all three {gamma} subunit complexes in cultured human cells by inhibiting the respiratory chain
We report that the AMPK activator PT-1 selectively increased the activity of γ1- but not γ3-containing complexes in incubated mouse muscle. PT-1 increased the AMPK-dependent phosphorylation of the autophagy-regulating kinase ULK1 on Ser555, but not proposed AMPK-γ3 substrates such as Ser231 on TBC1D1 or Ser212 on ACC2, nor did it stimulate glucose transport. Surprisingly, however, in HEK-293 cells expressing human γ1, γ2 or γ3, PT-1 activated all three complexes equally. We were unable to reproduce previous findings suggesting that PT-1 activates AMPK by direct binding between the ...
Source: BJ Signal - February 19, 2015 Category: Biochemistry Authors: T Elbenhardt Jensen, F A Ross, M Kleinert, L Sylow, J R. Knudsen, G J. Gowans, D Grahame Hardie, E A. Richter Tags: BJ Signal Source Type: research

Severe Respiratory Illness Associated With Enterovirus D68—Missouri and Illinois, 2014
Publication date: March 2015 Source:Annals of Emergency Medicine, Volume 65, Issue 3 (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 19, 2015 Category: Emergency Medicine Source Type: research

Prenatal-perinatal Nicotine Alters Neonatal Raphe Neurons: Meaning for Sudden Infant Death Syndrome.
Abstract Nicotine may link maternal cigarette smoking with respiratory dysfunctions in sudden infant death syndrome (SIDS). Prenatal-perinatal nicotine exposure blunts ventilatory responses to hypercapnia and reduces central respiratory chemoreception in mouse neonates at postnatal days 0-3 (P0-P3). This suggests that raphe neurons, which are altered in SIDS and contribute to central respiratory chemoreception, may be affected by nicotine. We therefore investigated whether prenatal-perinatal nicotine exposure affects the activity, electrical properties, and chemosensitivity of raphe obscurus (ROb) neurons in mouse ...
Source: American Journal of Respiratory Cell and Molecular Biology - February 19, 2015 Category: Molecular Biology Authors: Cerpa VJ, Aylwin ML, Beltrán-Castillo S, Bravo EU, Llona IR, Richerson GB, Eugenín JL Tags: Am J Respir Cell Mol Biol Source Type: research

Automated High Performance Analysis of Lung Morphometry.
In conclusion, this novel approach allowed the collection of new fundamental morphometric data on lung development and a deeper comprehension of the effect of hyperoxia. PMID: 25695836 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - February 19, 2015 Category: Molecular Biology Authors: Sallon C, Soulet D, Provost PR, Tremblay Y Tags: Am J Respir Cell Mol Biol Source Type: research

Changes in the endurance shuttle walk test in COPD patients with chronic respiratory failure after pulmonary rehabilitation: the minimal important difference obtained with anchor- and distribution-based method
Conclusions: Estimates of the MID for the ESWT after PR showed only small differences using different anchors in patients with COPD and chronic respiratory failure. Therefore we recommend using a range of 186–199 s, 76–82% or 154–164 m as MID of the ESWT in COPD patients with chronic respiratory failure. Further research in larger populations should elucidate whether this cut-off value is also valid in other COPD populations and with other interventions.Trial registrationClinicalTrials.Gov (ID NCT00135538). (Source: Respiratory Research)
Source: Respiratory Research - February 19, 2015 Category: Respiratory Medicine Authors: Wytske AltenburgMarieke DuivermanNick ten HackenHuib KerstjensMathieu de GreefPeter WijkstraJohan Wempe Source Type: research

Preoperative Opioid Misuse is Associated With Increased Morbidity and Mortality After Elective Orthopaedic Surgery.
CONCLUSION: Opioid abuse and dependence are increasing rapidly among orthopaedic surgical inpatients and are associated with considerable postoperative morbidity and mortality and resource utilization. We recommend that orthopaedic surgeons screen patients carefully for opioid misuse preoperatively, help patients who are using opioids inappropriately to discontinue them before scheduling elective surgery, decline to perform elective surgery in patients who misuse opioids, and closely monitor patients who are habituated to opioids at the time they undergo surgery. LEVEL OF EVIDENCE: Level III, prognostic study. PMID...
Source: Clinical Orthopaedics and Related Research - February 19, 2015 Category: Orthopaedics Authors: Menendez ME, Ring D, Bateman BT Tags: Clin Orthop Relat Res Source Type: research

Association of Hospital-Level Volume of Extracorporeal Membrane Oxygenation Cases and Mortality - Analysis of the Extracorporeal Life Support Organization Registry.
Conclusions: In this international, case-mix-adjusted analysis, higher annual hospital ECMO volume was associated with lower mortality in 1989-2013 for neonates and adults; the association among adults persisted in 2008-2013. PMID: 25695688 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 19, 2015 Category: Respiratory Medicine Authors: Barbaro RP, Odetola FO, Kidwell KM, Paden ML, Bartlett RH, Davis MM, Annich GM Tags: Am J Respir Crit Care Med Source Type: research

Human Trachealis and Main Bronchi Smooth Muscle Are Normo-Responsive in Asthma.
Conclusions: Our data showed that, in contrast to some animal models of AHR, human tracheal and main bronchial smooth muscle contractility is not increased in asthma. Specifically, our results indicate that it is highly unlikely that ASM EC50 or Vmax contribute to AHR in asthma, but, because of high variability, we cannot conclude whether or not asthmatic ASM is hyperreactive. PMID: 25695616 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 19, 2015 Category: Respiratory Medicine Authors: Ijpma G, Kachmar L, Matusovsky OS, Bates JH, Benedetti A, Martin JG, Lauzon AM Tags: Am J Respir Crit Care Med Source Type: research

CXCR2 Antagonist MK-7123-A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease.
Conclusions: Treatment with MK-7123 50 mg vs. placebo led to significant improvement in FEV1 in COPD patients suggesting clinically important anti-inflammatory effects with CXCR2 antagonism, although dose-related discontinuations were observed due to ANC decreases with MK-7123. Greater response was observed in smokers vs. ex-smokers. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01006616. PMID: 25695403 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 19, 2015 Category: Respiratory Medicine Authors: Rennard SI, Dale DC, Donohue JF, Kanniess F, Magnussen H, Sutherland ER, Watz H, Lu S, Stryszak P, Rosenberg E, Staudinger H Tags: Am J Respir Crit Care Med Source Type: research

Diquat causes caspase-independent cell death in SH-SY5Y cells by production of ROS independently of mitochondria.
Abstract Evidence indicates that Parkinson's disease (PD), in addition to having a genetic aetiology, has an environmental component that contributes to disease onset and progression. The exact nature of any environmental agent contributing to PD is unknown in most cases. Given its similarity to paraquat, an agrochemical removed from registration in the EU for its suspected potential to cause PD, we have investigated the in vitro capacity of the related herbicide Diquat to cause PD-like cell death. Diquat showed greater toxicity towards SH-SY5Y neuroblastoma cells and human midbrain neural cells than paraquat and a...
Source: Archives of Toxicology - February 19, 2015 Category: Toxicology Authors: Nisar R, Hanson PS, He L, Taylor RW, Blain PG, Morris CM Tags: Arch Toxicol Source Type: research

PT-1 selectively activates AMPK-γ1 complexes in mouse skeletal muscle, but activates all three γ subunit complexes in cultured human cells by inhibiting the respiratory chain.
We report that the AMPK activator PT-1 selectively increased the activity of γ1- but not γ3-containing complexes in incubated mouse muscle. PT-1 increased the AMPK-dependent phosphorylation of the autophagy-regulating kinase ULK1 on Ser555, but not proposed AMPK-γ3 substrates such as Ser231 on TBC1D1 or Ser212 on ACC2, nor did it stimulate glucose transport. Surprisingly, however, in HEK-293 cells expressing human γ1, γ2 or γ3, PT-1 activated all three complexes equally. We were unable to reproduce previous findings suggesting that PT-1 activates AMPK by direct binding between the kinase and auto-inhibitory domains o...
Source: The Biochemical Journal - February 19, 2015 Category: Biochemistry Authors: Jensen TE, Ross FA, Kleinert M, Sylow L, Knudsen JR, Gowans GJ, Hardie DG, Richter EA Tags: Biochem J Source Type: research

Regulation of High glucose-mediated mucin expression by matrix metalloproteinase-9 in Human airway epithelial cells.
Abstract Mucus hypersecretion is the key manifestation in patients with chronic inflammatory airway diseases and mucin 5AC (MUC5AC) is a major component of airway mucus. Matrix metalloproteinases (MMP)-9, have been found to be involved in the pathogenesis of inflammatory airway diseases. Hyperglycemia has been shown to be an independent risk factor for respiratory infections. We hypothesize that high glucose (HG)-regulates MMP-9 production and MMP-9 activity through nicotinamide adenine dinucleotide phosphate (NADPH)/ reactive oxygen species (ROS) cascades pathways, leading to mucin production in human airway epith...
Source: Experimental Cell Research - February 19, 2015 Category: Cytology Authors: Yu H, Yang J, Xiao Q, Lü Y, Zhou X, Xia L, Nie D Tags: Exp Cell Res Source Type: research

Global Multilocus Sequence Typing Analysis of Mycoplasma bovis Isolates Reveals Two Main Population Clusters [Clinical Veterinary Microbiology]
Mycoplasma bovis is a major bovine pathogen associated with bovine respiratory disease complex and is responsible for substantial economic losses worldwide. M. bovis is also associated with other clinical presentations in cattle, including mastitis, otitis, arthritis, and reproductive disorders. To gain a better understanding of the genetic diversity of this pathogen, a multilocus sequence typing (MLST) scheme was developed and applied to the characterization of 137 M. bovis isolates from diverse geographical origins, obtained from healthy or clinically infected cattle. After in silico analysis, a final set of 7 housekeepi...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Rosales, R. S., Churchward, C. P., Schnee, C., Sachse, K., Lysnyansky, I., Catania, S., Iob, L., Ayling, R. D., Nicholas, R. A. J. Tags: Clinical Veterinary Microbiology Source Type: research

Pyogranulomatous Pneumonia in Goats Caused by an Undescribed Porphyromonas Species, "Porphyromonas katsikii" [Clinical Veterinary Microbiology]
A yet-undescribed bacterial species, tentatively named "Porphyromonas katsikii," was isolated from individuals of a small goat herd with pyogranulomatous pneumonia during an outbreak of acute respiratory disease. The isolated bacteria grew in the form of black-pigmented colonies after 14 days of incubation under anaerobic conditions at 37°C on a tryptic soy blood agar medium. The bacteria were identified as a yet-undescribed Porphyromonas species by determination of the nucleotide sequence of the rrs 16S rRNA gene, and this species was tentatively named Porphyromonas katsikii. PCR amplification with specific primers fo...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Filioussis, G., Petridou, E., Karavanis, E., Frey, J. Tags: Clinical Veterinary Microbiology Source Type: research

Isolation and Characterization of Influenza C Viruses in the Philippines and Japan [Virology]
From November 2009 to December 2013 in the Philippines, 15 influenza C viruses were isolated, using MDCK cells, from specimens obtained from children with severe pneumonia and influenza-like illness (ILI). This is the first report of influenza C virus isolation in the Philippines. In addition, from January 2008 to December 2013, 7 influenza C viruses were isolated from specimens that were obtained from children with acute respiratory illness (ARI) in Sendai city, Japan. Antigenic analysis with monoclonal antibodies to the hemagglutinin-esterase (HE) glycoprotein showed that 19 strains (12 from the Philippines and 7 from Ja...
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Odagiri, T., Matsuzaki, Y., Okamoto, M., Suzuki, A., Saito, M., Tamaki, R., Lupisan, S. P., Sombrero, L. T., Hongo, S., Oshitani, H. Tags: Virology Source Type: research

Comparison of the Genedia MTB Detection Kit and the Cobas TaqMan MTB Assay for Detection of Mycobacterium tuberculosis in Respiratory Specimens [Mycobacteriology and Aerobic Actinomycetes]
The performance of the Genedia MTB detection kit was compared with that of the Cobas TaqMan MTB test using respiratory specimens. The Genedia and Cobas assays showed comparable sensitivities (81.8% and 78.8%, respectively) and specificities (99.8% and 99.5%, respectively), while the Genedia assay produced fewer invalid results and required less turnaround time and labor. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Huh, H. J., Kwon, H. J., Ki, C.-S., Lee, N. Y. Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research

Molecular Epidemiology of Enterovirus D68 from 2013 to 2014 in Philippines [Virology]
Enterovirus D68 (EV-D68) has been recognized as an important cause of acute respiratory infections. Here we report the molecular epidemiology of EV-D68 in Philippines from 2013 to 2014; we found cases in areas affected by Typhoon Haiyan and found new strains in the country. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - February 19, 2015 Category: Microbiology Authors: Furuse, Y., Chaimongkol, N., Okamoto, M., Imamura, T., Saito, M., Tamaki, R., Saito, M., Tohoku-RITM Collaborative Research Team, Lupisan, S. P., Oshitani, H. Tags: Virology Source Type: research

Assessment of Metabolic Flexibility of Old and Adult Mice Using Three Noninvasive, Indirect Calorimetry-Based Treatments
In conclusion, InCa analysis of the response to OxR in mice is a sensitive and reproducible treatment to noninvasively measure age-impaired metabolic health. (Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences)
Source: Journals of Gerontology Series A: Biological Sciences and Medical Sciences - February 19, 2015 Category: Geriatrics Authors: Duivenvoorde, L. P. M., van Schothorst, E. M., Swarts, H. J. M., Keijer, J. Tags: Original Article Source Type: research

Peripherally Inserted Central Catheters Complicated by Vascular Erosion in Neonates.
Abstract Peripherally inserted central catheters (PICCs) are widely used in the pediatric population, and their use continues to grow in popularity. These catheters provide a reliable source of venous access to neonatal patients but can also be the cause of life-threatening complications. There are several well-documented complications such as infections, catheter thrombosis, vascular extravasations, and fractured catheters. However, the complication of vascular erosion into the pleural space using both small and silicone-based catheters is rarely described. After obtaining institutional review board approval, we i...
Source: JPEN Journal Of Parenteral And Enteral Nutrition - February 19, 2015 Category: Nutrition Authors: Blackwood BP, Farrow KN, Kim S, Hunter CJ Tags: JPEN J Parenter Enteral Nutr Source Type: research

Recurrent extramedullary plasmacytoma in asymptomatic multiple myeloma: a case report
Conclusions In this case report we describe the rapid appearance of extramedullary plasmacytomas in the background of an asymptomatic multiple myeloma. An immunohistochemical analysis was negative for CD56 and showed high MIB-1 expression in the extramedullary plasmacytoma and low MIB-1 expression in the bone marrow, contributing to the potential underlying pathophysiology of the recurrent extramedullary plasmacytomas and their genetic changes. Systemic chemotherapy was started and no fourth extramedullary plasmacytoma has developed since. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - February 19, 2015 Category: Journals (General) Source Type: research

Driving Pressure and Survival in the Acute Respiratory Distress Syndrome
New England Journal of Medicine, Volume 372, Issue 8, Page 747-755, February 2015. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - February 18, 2015 Category: Internal Medicine Tags: article Source Type: research

Driving Pressure and Respiratory Mechanics in ARDS
New England Journal of Medicine, Volume 372, Issue 8, Page 776-777, February 2015. (Source: New England Journal of Medicine)
Source: New England Journal of Medicine - February 18, 2015 Category: Internal Medicine Tags: article Source Type: research

One-Year Safety of Olodaterol Once Daily via Respimat® in Patients with GOLD 2–4 Chronic Obstructive Pulmonary Disease: Results of a Pre-Specified Pooled Analysis
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - February 18, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Professor Heinrich W. Herzog (1920-2014)
Respiration (Source: Respiration)
Source: Respiration - February 18, 2015 Category: Respiratory Medicine Source Type: research

A prospective 10-year follow-up polygraphic study of patients treated with a mandibular protruding device
Conclusions MPD treatment is well tolerated and effective in a long-term, 10-year perspective. Weight gain may jeopardize MPD effects. Both patients and relatives reported significantly less snoring and fewer periods of apnea. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Utility of extended cardiac monitoring to detect atrial fibrillation in patients with severe obstructive sleep apnea
Conclusion In patients with severe OSA without a known history of AF, 7 days of extended cardiac monitoring with an ECG event recorder did not detect clinically meaningful, silent AF. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Changes of visual field and optic nerve fiber layer in patients with OSAS
Conclusions OSAS had a high prevalence of POAG. Visual field was damaged and the RNFL was thinned. Due to diverse CSFP, RNFL changed differently in the patients with severe OSAS. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Association between nocturnal hypoxia and liver injury in the setting of nonalcoholic fatty liver disease
Conclusions OSA-related hypoxia was independently associated with the biochemical evidence of liver injury in the presence of NAFLD. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Nasal insufflation treatment adherence in obstructive sleep apnea
Conclusions This study showed similar adherence to NI and CPAP over a short period of usage. A randomized clinical trial is now essential for determining the comparative effectiveness of NI therapy in relation to treatment with CPAP. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Hypoxia: a consequence of obesity and also a tool to treat excessive weight loss
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

The effect of obstructive sleep apnea syndrome and snoring severity to intima-media thickening of carotid artery
Conclusion Carotid artery IMT, which is an early finding of atherosclerosis, was found to be highly correlated with OSAS and snoring severity. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Swallowing and breathing patterns during sleep in patients with obstructive sleep apnea
Conclusions Swallowing frequency during sleep can increase with increasing OSA severity in most OSA patients. These events are predominately associated with respiratory event-related arousals and are more frequent when preceded by oronasal breathing. The observed swallowing under high ventilatory needs may compromise the maintenance of the pharynx as a conduit for airflow in OSA patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Oropharyngeal exercises to reduce symptoms of OSA after AT
Conclusions Oropharyngeal exercises may be considered as complementary therapy to adenotonsillectomy to effectively treat pediatric OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Author response to: Endothelial function is not always well preserved in obese patients with mild OSA
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Author response to: hypoxia a consequence of obesity and also a tool to treat excessive weight loss
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Response to letter on “Validation study on sleep parameters by actigraphy for normal subjects”
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Should you screen all your sleep apnea patients for thyroid disease?
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Endothelial function is not always well preserved in obese patients with mild OSA
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

Erratum to: Videoendoscopic diagnosis for predicting the response to oral appliance therapy in severe obstructive sleep apnea
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research

The influence of nasal abnormalities in adherence to continuous positive airway pressure device therapy in obstructive sleep apnea patients. What role does the nose play?
(Source: Sleep and Breathing)
Source: Sleep and Breathing - February 18, 2015 Category: Respiratory Medicine Source Type: research