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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma.
Abstract Follicular bronchiolitis (FB) is a rare small-airway pathology that is associated mainly with connective tissue diseases. This case report presents a new, diagnosed, different airway disease in a non-smoker with rheumatoid arthritis in remission who was treated for presumed asthma, but was not controlled. She was ultimately diagnosed with FB after video-assisted thoracoscopic surgery. The clinical findings of FB were controlled successfully by colchicine after she did not respond to systemic steroid therapy. This is the first case report of FB associated with rheumatoid arthritis that responded to colchici...
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Goksel O, Nart D, Ergonul AG, Sever F, Goksel T Tags: Respir Care Source Type: research

Clinical Predictors of Obesity Hypoventilation Syndrome in Obese Subjects With Obstructive Sleep Apnea.
CONCLUSIONS: Serum bicarbonate level and nadir saturation were independent predictive factors for the diagnosis of OHS. PMID: 25587164 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Bingol Z, Pihtili A, Cagatay P, Okumus G, Kiyan E Tags: Respir Care Source Type: research

Spirometry Quality in Adults With Very Severe Lung Function Impairment.
CONCLUSIONS: Severe lung disease should not be used as an excuse for not meeting spirometry quality goals. PMID: 25587163 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Torre-Bouscoulet L, Velázquez-Uncal M, García-Torrentera R, Gochicoa-Rangel L, Fernández-Plata R, Enright P, Pérez-Padilla R Tags: Respir Care Source Type: research

A Comparison of Metered-Dose Inhaled Albuterol Versus Endotracheal Liquid Bolus Albuterol for the Treatment of Bronchoconstriction.
CONCLUSIONS: ELB albuterol lavage may be a viable option to reverse bronchoconstriction in intubated patients with limited response to traditional aerosolized albuterol via MDI. PMID: 25587162 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Johnston DA, Gilmore TW, Gosselin KP Tags: Respir Care Source Type: research

Muscle Impairment in Neuromuscular Disease Using an Expiratory/Inspiratory Ratio.
CONCLUSIONS: Healthy individuals and subjects with NMDs showed higher PEmax in comparison to PImax regarding the PEmax/PImax ratio. Based on the ratio, it is possible to state that NMDs show different patterns of respiratory muscle strength loss. PEmax/PImax ratio is a useful parameter to assess the impairment of respiratory muscles in a patient and to customize rehabilitation and treatment. PMID: 25587161 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Fregonezi G, Azevedo IG, Resqueti VR, De Andrade AD, Gualdi LP, Aliverti A, Dourado-Junior ME, Parreira VF Tags: Respir Care Source Type: research

A Evaluation of an Oxygen Mask-Based Capnometry Device in Subjects Extubated After Abdominal Surgery.
CONCLUSIONS: It is possible to measure the PETCO2 under varying breathing conditions with the capnometry-type oxygen mask in subjects receiving oxygen supplementation after extubation following upper abdominal surgery to determine whether they are properly ventilating. PMID: 25587160 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Takaki S, Mihara T, Mizutani K, Yamaguchi O, Goto T Tags: Respir Care Source Type: research

Neurally Adjusted Ventilatory Assist Improves Patient-Ventilator Synchrony in a Patient With Tetanus and Unstable Diaphragmatic Electrical Activity.
Abstract A 79-y-old man with generalized tetanus was admitted to the ICU. A left-forearm wound was surgically debrided, and the wound was closed. On postoperative day 1, after the patient experienced opisthotonos and convulsions, endotracheal intubation was performed. Propofol and diazepam were infused but failed to stop the convulsions. Morphine, midazolam, dantrolene, and rocuronium were used to ameliorate the muscle spasms. Magnesium sulfate was also infused. On postoperative day 15, patient-ventilator asynchrony was apparent. The patient showed recurrent tachypnea and bradypnea, which seemed typical of Cheyne-S...
Source: Respiratory Care - January 13, 2015 Category: Respiratory Medicine Authors: Tane N, Okuda N, Imanaka H, Nishimura M Tags: Respir Care Source Type: research

Geriatric Assessement a Key Tool in the Initial Management of the Elderly Patient with Community-Acquired Pneumonia.
PMID: 25595940 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 13, 2015 Category: Respiratory Medicine Authors: Martín-Sánchez FJ, Castillo JG Tags: Arch Bronconeumol Source Type: research

High-Attenuation Mucus in Allergic Bronchopulmonary Aspergillosis.
PMID: 25595939 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 13, 2015 Category: Respiratory Medicine Authors: Kouzaki Y, Kanoh S, Kawana A Tags: Arch Bronconeumol Source Type: research

A technique for endobronchial ultrasound-guided fine needle aspiration.
PMID: 25595938 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 13, 2015 Category: Respiratory Medicine Authors: Arroyo-Cózar M, Forero de la Sotilla A, Herrero Mosquete R, Gil Marín B Tags: Arch Bronconeumol Source Type: research

Ebola virus: Understanding the 2014 outbreak.
PMID: 25595937 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 13, 2015 Category: Respiratory Medicine Authors: Lorente JÁ, Blanch L, Esteban A Tags: Arch Bronconeumol Source Type: research

Interaction between dimer interface residues of native and mutated SOD1 protein: a theoretical study.
Abstract Cu-Zn superoxide dismutase 1 (SOD1) is a highly conserved bimetallic protein enzyme, used for the scavenging the superoxide radicals (O2 (-)) produced due to aerobic metabolism in the mitochondrial respiratory chain. Over 100 mutations have been identified and found to be in the homodimeric structure of SOD1. The enzyme has to be maintained in its dimeric state for the structural stability and enzymatic activity. From our investigation, we found that the mutations apart from the dimer interface residues are found to affect the dimer stability of protein and hence enhancing the aggregation and misfolding te...
Source: Journal of Biological Inorganic Chemistry : JBIC - January 13, 2015 Category: Chemistry Authors: Keerthana SP, Kolandaivel P Tags: J Biol Inorg Chem Source Type: research

zThe Neuroprotective Role of Metformin in Advanced Glycation End Products Treated Human Neural Stem Cells is AMPK-Dependent.
This study further suggests AMPK may be a potential therapeutic target for treating diabetic neurodegeneration. PMID: 25595658 [PubMed - as supplied by publisher] (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - January 13, 2015 Category: Biochemistry Authors: Chung MM, Chen YL, Pei D, Cheng YC, Sun B, Nicol CJ, Yen CH, Chen HM, Liang YJ, Chiang MC Tags: Biochim Biophys Acta Source Type: research

Oxygen Saturation Index and Severity of Hypoxic Respiratory Failure.
Conclusion: OSI correlates significantly with OI in infants with HRF. This noninvasive measure may be used to assess the severity of HRF and PPHN in neonates without arterial access. © 2015 S. Karger AG, Basel. PMID: 25592054 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - January 13, 2015 Category: Perinatology & Neonatology Authors: Rawat M, Chandrasekharan PK, Williams A, Gugino S, Koenigsknecht C, Swartz D, Ma CX, Mathew B, Nair J, Lakshminrusimha S Tags: Neonatology Source Type: research

Comparison of Turnaround Time (TAT) and Time to Oseltamivir Discontinuation between Two Respiratory Viral Panel Testing (RVP) Methodologies.
Abstract Multiplex PCR is highly sensitive and provides a more rapid turnaround time (TAT) compared to other respiratory viral testing methodologies. Our microbiology laboratory switched from the Luminex xTAG® RVP (detects 12 respiratory viruses with an assay time of 8.5 hours) to the Biofire Diagnostics, Inc. FilmArray®-RP (detects 17 respiratory viral and 3 bacterial targets with an assay time of 1.2 hours). We sought to compare the TAT between the two respiratory viral panels (RVP) performed at different frequencies and determine time to discontinuation of empiric oseltamivir. All adult patients with an RVP te...
Source: Journal of Medical Microbiology - January 13, 2015 Category: Microbiology Authors: Pettit N, Matushek S, Charnot-Katsikas A, Tesic V, Boonlayangoor S, Brielmaier B, Pisano J Tags: J Med Microbiol Source Type: research

Compound 48/80 acts as a potent mucosal adjuvant for vaccination against Streptococcus pneumoniae infection in young mice.
In this study, the adjuvanticity of C48/80 was evaluated when intranasally co-administrated with a pneumococcal vaccine candidate strain SPY1 in a young mice model in comparison with a classical mucosal adjuvant cholera toxin (CT) and a relatively safe mucosal adjuvant Pam2CSK4. All three adjuvants enhanced antibody responses, whereas serum IgG titers were maintained at a stable level during the 3 months after the last immunization only in the SPY1+C48/80 and SPY1+CT groups. Furthermore, both the SPY1+CT group and the SPY1+C48/80 group induced strong Th17 immune response. Notably, C48/80 showed the exceptional ability to p...
Source: Vaccine - January 13, 2015 Category: Allergy & Immunology Authors: Zeng L, Liu Y, Wang H, Liao P, Song Z, Gao S, Wu Y, Zhang X, Yin Y, Xu W Tags: Vaccine Source Type: research

Best approach to measuring the inferior vena cava in spontaneously ventilating patients: a pilot study
The objective of this study was to establish the reliability of different measurements of inferior vena cava (IVC) size and respiratory variation in response to changes in circulating volume. Transabdominal ultrasound measurements of the IVC were obtained in longitudinal (B and M modes) and transverse planes (B-mode height and ellipse circumference) during inspiration and expiration, and inferior vena cava collapsibility indices (IVCci) were calculated. Measurements were repeated following venesection of ∼450 ml. Thirty patients underwent venesection. Their IVCci increased significantly for transverse and longitudinal he...
Source: European Journal of Emergency Medicine - January 12, 2015 Category: Emergency Medicine Tags: Short Reports Source Type: research

Intubation after noninvasive ventilation failure in chronic obstructive pulmonary disease: associated factors at emergency department presentation
Objective: Noninvasive ventilation (NIV) is a common practice in acute hypercapnic respiratory failure (AHRF) because of exacerbation of chronic obstructive pulmonary disease (COPD). However, a recent study has shown that patients who require invasive mechanical ventilation (IMV) after failure of NIV experience high mortality rates (up to 30%). Therefore, the aim of this study is to determine the parameters, specifically for emergency department (ED) presentation, associated with the transition from NIV to IMV because of NIV failure. Patients and methods: This is a 4-year retrospective cohort study in the EDs of two Dutch ...
Source: European Journal of Emergency Medicine - January 12, 2015 Category: Emergency Medicine Tags: Original Articles Source Type: research

Oxygen Saturation Index and Severity of Hypoxic Respiratory Failure
Conclusion: OSI correlates significantly with OI in infants with HRF. This noninvasive measure may be used to assess the severity of HRF and PPHN in neonates without arterial access.Neonatology 2015;107:161-166 (Source: Neonatology)
Source: Neonatology - January 12, 2015 Category: Perinatology & Neonatology Source Type: research

Efficacy and safety of reslizumab in patients with moderate to severe eosinophilic asthma
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - January 12, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Lack of Middle East Respiratory Syndrome Coronavirus Transmission from Infected Camels
M. G. Hemida et al. (Source: Emerging Infectious Diseases Journal)
Source: Emerging Infectious Diseases Journal - January 12, 2015 Category: Infectious Diseases Source Type: research

Evaluation of lung recruitment maneuvers in acute respiratory distress syndrome using computer simulation
Conclusions: There appears to be significant scope for reducing the peak levels of PEEP originally specified in the MRS and hence to avoid exposing the lung to unnecessarily high pressures. More generally, our study highlights the huge potential of computer simulation to assist in evaluating the efficacy of different recruitment maneuvers, in understanding their modes of operation, in optimizing RMs for individual patients, and in supporting clinicians in the rational design of improved treatment strategies. (Source: BioMed Central)
Source: BioMed Central - January 12, 2015 Category: Journals (General) Authors: Anup DasOana ColeMarc ChikhaniWenfei WangTayyba AliMainul HaqueDeclan G BatesJonathan G Hardman Source Type: research

The Prospective Non-Interventional DACCORD Study in the National COPD Registry in Germany: design and methods
DiscussionFor 2016 we expect important results regarding longitudinal development of PRO's including exacerbations, lung function, adherence and side effects. We also investigate applicability of the new GOLD staging system in usual care. Data on diagnostic and treatment modalities in current German primary and secondary care, as well as pharmaco-economic data will be generated.Trial registration: 1. German Register for non-interventional studies: http://www.vfa.de/de/arzneimittel-forschung/datenbanken-zu-arzneimitteln/nisdb.2. EMA EnCePP http://www.encepp.eu/. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - January 12, 2015 Category: Respiratory Medicine Authors: Peter KardosClaus VogelmeierRoland BuhlCarl-Peter CriéeHeinrich Worth Source Type: research

YKL-40 is correlated with FEV1 and the asthma control test (ACT) in asthmatic patients: influence of treatment
Conclusions: YKL-40 was reduced in the serum of asthmatic patients after appropriate treatment, and the levels correlated with improvements in %FEV1 and ACT. High levels of serum YKL-40 may be refractory to current asthma treatments.Trial registration: ChiCTR-OCC-13003316 (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - January 12, 2015 Category: Respiratory Medicine Authors: Tianwen LaiMin ChenZaichun DengYingying L¿Dong WuDongming LiBin Wu Source Type: research

Preliminary Study on Prevalence, Risk Factor and Genetic Homogeneity of Porcine Reproductive and Respiratory Syndrome Virus in Registered Pig Farms in Heilongjiang, China
Summary While porcine reproductive and respiratory syndrome (PRRS) causes great economic losses in southern and central China, systematic studies on the epidemiology of PRRS virus (PRRSV) in Heilongjiang Province had not been performed. Therefore, we conducted a preliminary study to estimate the prevalence and risk factors associated with PRRSV infection, as well as characterize the PRRSV in registered pig farms in Heilongjiang Province, China in 2011. A total of 1237 blood samples were collected from 72 farms and tested by reverse transcription polymerase chain reaction (RT‐PCR) for PRRSV. Risk factors associated to PRR...
Source: Transboundary and Emerging Diseases - January 12, 2015 Category: Veterinary Research Authors: J. Wang, H. Wen, S. Wang, W. Sun, N. Shen, Z. Liu, Y. Liu, Y. Liu, C. Jiang, G. Sun, F. Goutard, X. Cai Tags: Original Article Source Type: research

NADPH Oxidase‐Dependent NLRP3 Inflammasome Activation and its Important Role in Lung Fibrosis by Multiwalled Carbon Nanotubes
In this study, three long aspect ratio (LAR) materials (MWCNTs, single‐walled carbon nanotubes, and silver nanowires) are used to compare with spherical carbon black and silver nanoparticles for their ability to trigger oxygen burst activity and NLRP3 assembly. All LAR materials but not spherical nanoparticles induce robust NADPH oxidase activation and respiratory burst activity in THP‐1 cells, which are blunted in p22phox‐deficient cells. The NADPH oxidase is directly involved in lysosomal damage by LAR materials, as demonstrated by decreased cathepsin B release and IL‐1β production in p22phox‐deficient cells. ...
Source: Small - January 12, 2015 Category: Nanotechnology Authors: Bingbing Sun, Xiang Wang, Zhaoxia Ji, Meiying Wang, Yu‐Pei Liao, Chong Hyun Chang, Ruibin Li, Haiyuan Zhang, André E. Nel, Tian Xia Tags: Full Paper Source Type: research

Cerebral microhaemorrhages secondary to fat embolus syndrome in sickle cell disease
Introduction Fat embolus syndrome (FES) is a distinct pattern of clinical symptoms and signs following circulation of fat globules, or emboli, in the lung parenchyma and peripheral circulation. It leads to multisystem dysfunction, most commonly involving the lungs, skin, brain and kidneys. It is usually seen following trauma; however, it is a rare but potentially fatal and under-diagnosed complication of bone marrow infarction in patients with sickle cell disease. Neurological involvement forms part of the classical clinical triad of presentation, composed of respiratory changes, neurological abnormalities and a petechial ...
Source: Postgraduate Medical Journal - January 12, 2015 Category: Journals (General) Authors: Alobeidi, F., Inusa, B. P. D., Singh, R. R., U-King-Im, J. M., Lim Tags: Immunology (including allergy), Drugs: cardiovascular system, Drugs: CNS (not psychiatric), Pain (neurology), Hypertension, Radiology, Adult intensive care, Pulmonary hypertension, Clinical diagnostic tests, Radiology (diagnostics) Images in medicine Source Type: research

Endotoxin-induced lung alveolar cell injury causes brain cell damage
Sepsis is the most common cause of acute respiratory distress syndrome, a severe lung inflammatory disorder with an elevated morbidity and mortality. Sepsis and acute respiratory distress syndrome involve the release of inflammatory mediators to the systemic circulation, propagating the cellular and molecular response and affecting distal organs, including the brain. Since it has been reported that sepsis and acute respiratory distress syndrome contribute to brain dysfunction, we investigated the brain-lung crosstalk using a combined experimental in vitro airway epithelial and brain cell injury model. Conditioned medi...
Source: Experimental Biology and Medicine - January 12, 2015 Category: Research Authors: Rodriguez-Gonzalez, R., Ramos-Nuez, A., Martin-Barrasa, J. L., Lopez-Aguilar, J., Baluja, A., Alvarez, J., Rocco, P. R., Pelosi, P., Villar, J. Tags: Translational Research Source Type: research

Multidisciplinary Lung Cancer Meetings: Improving the practice of radiation oncology and facing future challenges
Abstract Clinical guidelines widely recognize the importance of multidisciplinary meetings (MDM) in the optimal care of lung cancer patients. The published literature suggest that dedicated Lung Cancer MDM lead to increased treatment utilization rates and improved survival outcomes for patients with lung cancer. For radiation oncologists, Lung Cancer MDM have been proven to support evidence‐based practice and improve the utilization of radiotherapy. Lung Cancer MDM also allow for education and promotion of specialty radiotherapy services. The fast pace of modern medicine is also presenting new challenges for the multidis...
Source: Respirology - January 12, 2015 Category: Respiratory Medicine Authors: Belinda A. Campbell, David Ball, Françoise Mornex Tags: Invited Review Series: Lung Cancer Practice, Implementing Evidence around the World Source Type: research

Importance of national context in the translation of personalised treatments for smoking cessation
Publication date: Available online 12 January 2015 Source:The Lancet Respiratory Medicine Author(s): Jennifer J Ware , Neil M Davies , Marcus R Munafò (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - January 12, 2015 Category: Respiratory Medicine Source Type: research

Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial
Publication date: Available online 12 January 2015 Source:The Lancet Respiratory Medicine Author(s): Caryn Lerman , Robert A Schnoll , Larry W Hawk Jr , Paul Cinciripini , Tony P George , E Paul Wileyto , Gary E Swan , Neal l Benowitz , Daniel F Heitjan , Rachel F Tyndale Background Substantial variability exists in therapeutic response and adverse effects with pharmacotherapies for tobacco dependence. Biomarkers to optimise treatment choice for individual smokers might improve treatment outcomes. We tested whether a genetically informed biomarker of nicotine clearance, the nicotine metabolite ratio (NMR; 3′-hydroxycot...
Source: The Lancet Respiratory Medicine - January 12, 2015 Category: Respiratory Medicine Source Type: research

Confined Space Ventilation by Shipyard Welders: Observed Use and Effectiveness
Shipbuilding involves intensive welding activities within enclosed and confined spaces, and although ventilation is commonly used in the industry, its use and effectiveness has not been adequately documented. Workers engaged in welding in enclosed or confined spaces in two shipyards were observed for their use of ventilation and monitored for their exposure to particulate matter. The type of ventilation in use, its placement and face velocity, the movement of air within the space, and other ventilation-related parameters were recorded, along with task characteristics such as the type of welding, the welder’s position...
Source: Annals of Occupational Hygiene - January 12, 2015 Category: Occupational Health Authors: Pouzou, J. G., Warner, C., Neitzel, R. L., Croteau, G. A., Yost, M. G., Seixas, N. S. Tags: Short communication Source Type: research

Peripheral nerve and neuromuscular junction pathology in Pompe disease
Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glycogen accumulation. Respiratory and ambulatory dysfunction are prominent features in patients with Pompe yet the mechanism defining the development of muscle weakness is currently unclear. Transgenic animal models of Pompe disease mirroring the patient phenotype have been invaluable in mechanistic and therapeutic study. Here, we demonstrate significant pathological alterations at neuromuscular junctions (NMJs) of the diaphragm and tibialis anterior muscle as prominent features of disease...
Source: Human Molecular Genetics - January 12, 2015 Category: Genetics & Stem Cells Authors: Falk, D. J., Todd, A. G., Lee, S., Soustek, M. S., ElMallah, M. K., Fuller, D. D., Notterpek, L., Byrne, B. J. Tags: ARTICLES Source Type: research

A motion-compensated image filter for low-dose fluoroscopy in a real-time tumor-tracking radiotherapy system
In the real-time tumor-tracking radiotherapy system, a surrogate fiducial marker inserted in or near the tumor is detected by fluoroscopy to realize respiratory-gated radiotherapy. The imaging dose caused by fluoroscopy should be minimized. In this work, an image processing technique is proposed for tracing a moving marker in low-dose imaging. The proposed tracking technique is a combination of a motion-compensated recursive filter and template pattern matching. The proposed image filter can reduce motion artifacts resulting from the recursive process based on the determination of the region of interest for the next frame ...
Source: Journal of Radiation Research - January 12, 2015 Category: Physics Authors: Miyamoto, N., Ishikawa, M., Sutherland, K., Suzuki, R., Matsuura, T., Toramatsu, C., Takao, S., Nihongi, H., Shimizu, S., Umegaki, K., Shirato, H. Tags: Physics Source Type: research

Improvement of antibiotic prescription in outpatient care: a cluster-randomized intervention study using a sentinel surveillance network of physicians
Conclusions In our setting, implementing guidelines, coupled with sustained individual feedback, was not able to reduce the proportion of sinusitis and other upper RTIs treated with antibiotics, but increased the use of recommended antibiotics for RTIs and UTIs, as defined by the guidelines. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - January 12, 2015 Category: Microbiology Authors: Hurlimann, D., Limacher, A., Schabel, M., Zanetti, G., Berger, C., Muhlemann, K., Kronenberg, A., on behalf of the Swiss Sentinel Working Group, Piero, Hans-Ruedi, Pierre, Andreas, Charles, Peter, Martine, Dagmar, Lilli, Thomas, Marco, Bridevaux, Jorg, Be Tags: Original research Source Type: research

Investigation of the Efficacy of Generic and Brand-Name Tiotropium Bromide in the Management of Chronic Obstructive Pulmonary Disease: A Randomized Comparative Trial
Conclusion The findings of this comparative trial showed equivalent efficacy and safety of Spiriva® and Tiova® in lessening the symptoms as well as improving the quality of life in patients with COPD. This finding has an important translational value given the significantly lower costs of generic versus brand-name products. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 12, 2015 Category: Drugs & Pharmacology Source Type: research

Polarization Affects Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells.
In conclusion, we determined that AEC conditioning favoring cellular integrity leads to a tolerogenic MDDC phenotype, which is likely to be important in regulating immune responses against commonly inhaled allergens. PMID: 25580629 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - January 12, 2015 Category: Molecular Biology Authors: Papazian D, Chhoden T, Arge M, Vorup-Jensen T, Nielsen CH, Lund K, Würtzen PA, Hansen S Tags: Am J Respir Cell Mol Biol Source Type: research

Abstract B07: Metabolic liabilities of human colon carcinoma spheroids are different compared to standard 2D cultures
The search for metabolic liabilities in tumor cells is typically performed in standard 2D cultures. This approach lacks the 3D context and heterogeneity of tumor tissue in vivo, which has significant impact on their metabolic behavior. One solution to modeling complex tumor cell interactions is to use cultured tumor spheroids. To assess bioenergetic function in individual spheroids, a modified, 96-well plate for the Seahorse Bioscience XFe96 Extracellular Flux Analyzer was created. Here, we demonstrate the capability of measuring mitochondrial oxygen consumption – a measure or mitochondrial respiration – and extracellu...
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Dranka, B. P., Swain, P., Rogers, G. W., Divakaruni, A. S., Neilson, A., Ferrick, D. A. Tags: Tumor Microenvironment and Metabolic Adaptation Source Type: research

Abstract B87: Prolyl hydroxylase and the regulation of reactive oxygen species (ROS) levels in cancer cells
Hypoxic microenvironments frequently exist within many solid tumors with oxygen levels fluctuating temporally and spatially from normoxia to hypoxia. The response to hypoxia in human cells is mainly regulated by hypoxia-inducible factors or HIFs, a family of transcription factors which orchestrate signalling events promoting cancer stem cells, leading to angiogenesis and increased tumorigenesis. Several events conspire together to stabilize HIF-αs to become constitutively expressed in many cancer cell types, regardless of oxygen levels. Prolyl hydroxylases (PHDs) play a crucial role in HIF regulation by hydroxylating HIF ...
Source: Cancer Research - January 12, 2015 Category: Cancer & Oncology Authors: Philip, B., Ito, K., Moreno-Sanchez, R., Ralph, S. J. Tags: The Evolving Tumor Microenvironment Source Type: research