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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

The global burden of respiratory disease—Impact on child health
Summary Respiratory disease is the major cause of mortality and morbidity worldwide, with infants and young children especially susceptible. The spectrum of disease ranges from acute infections to chronic non‐communicable diseases. Five respiratory conditions dominate—acute respiratory infections, chronic obstructive pulmonary disease, asthma, tuberculosis (TB), and lung cancer. Pneumonia remains the predominant cause of childhood mortality, causing nearly 1.3 million deaths each year, most of which are preventable. Asthma is the commonest non‐communicable disease in children. Pediatric TB constitutes up to 20% of th...
Source: Pediatric Pulmonology - March 1, 2014 Category: Respiratory Medicine Authors: Heather J. Zar, Thomas W. Ferkol Tags: Editorial Source Type: research

[Antenatal corticosteroid therapy and late preterm infant morbidity and mortality.]
CONCLUSIONS: Our finding suggests that the administration of antenatal corticosteroids to patients at risk of 34-36weeks delivery could significantly reduce the cost and acute morbidity associated with late preterm birth. PMID: 24593889 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - March 1, 2014 Category: Pediatrics Authors: Gázquez Serrano IM, Arroyos Plana A, Díaz Morales O, Herráiz Perea C, Holgueras Bragado A Tags: An Pediatr (Barc) Source Type: research

Pharmacological Basis for Medicinal Use of Lens culinaris in Gastrointestinal and Respiratory Disorders
Crude extract of Lens culinaris (Lc.Cr), which tested positive for presence of anthraquinones, flavonoids, saponins, sterol, tannins, and terpenes exhibited protective effect against castor oil‐induced diarrhea in mice at 100–1000 mg/kg. In rabbit jejunum preparations, Lc.Cr caused relaxation of spontaneous contractions at 0.03–5.0 mg/mL. Lc.Cr inhibited carbachol (CCh, 1 μM) and K+ (80 mM)‐induced contractions in a pattern similar to dicyclomine, but different from verapamil and atropine. Lc.Cr shifted the Ca++ concentration‐response curves to the right, like dicyclomine and verapamil. Pretreatment of t...
Source: Phytotherapy Research - March 1, 2014 Category: Biochemistry Authors: Munasib Khan, Arif‐ullah Khan, Najeeb‐ur‐ Rehman, Anwarul‐Hassan Gilani Tags: Research Article Source Type: research

A novel technique of non‐invasive ventilation: Pharyngeal oxygen with nose‐closure and abdominal‐compression—Aid for pediatric flexible bronchoscopy
ConclusionsPhO2‐NC‐AC is a simple, safe and effective NIV technique for respiratory support and rescue during various pediatric FB procedures. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 1, 2014 Category: Respiratory Medicine Authors: Wen‐Jue Soong, Mei‐Jy Jeng, Yu‐Sheng Lee, Pei‐Chen Tsao, Morgan Harloff, Yen‐Hui Matthew Soong Tags: Original Article: Other Source Type: research

Illness and Injury to Students on a School Excursion to Peru
ConclusionsOn this school excursion, the health problems encountered were consistent with those reported for other specialized tours, including expeditions and premium tours, although altitude illness needs to be carefully planned for in tours to higher elevation destinations as in South America. As well as being part of the service provided to the school students, the inclusion of a physician with appropriate medical supplies for this tour increased the independence of the travel group. A proposed medical kit for such an excursion is presented. (Source: Journal of Travel Medicine)
Source: Journal of Travel Medicine - March 1, 2014 Category: Infectious Diseases Authors: Marc T. M. Shaw, Elizabeth Harding, Peter A. Leggat Tags: ORIGINAL ARTICLE Source Type: research

Heparin‐binding protein (HBP/CAP37) – a link to endothelin‐1 in endotoxemia‐induced pulmonary oedema?
ConclusionsET‐receptor antagonism reduces porcine endotoxin‐induced pulmonary oedema and plasma levels of the oedema‐promoting protein HBP. Moreover, direct ET‐receptor stimulation distinctively increases plasma HBP. Together, these results suggest a novel mechanism by which ET‐1 contributes to formation of oedema during experimental sepsis. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - March 1, 2014 Category: Anesthesiology Authors: B. P. PERSSON, H. HALLDORSDOTTIR, L. LINDBOM, P. ROSSI, H. HERWALD, E. WEITZBERG, A. OLDNER Tags: Original Article Source Type: research

Acute effect of dietary fatty acid composition on postprandial metabolism in women
ConclusionsAcute ingestion of a PUFA‐rich HF meal induced a greater DIT in normal weight women compared to SFA‐ or MUFA‐rich HF meals. No significant differences were found for substrate utilization.This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - March 1, 2014 Category: Physiology Authors: Hui C. Clevenger, Amanda L. Kozimor, Chad M. Paton, Jamie A. Cooper Tags: Research Paper Source Type: research

Spontaneous pneumothorax in cats
Pneumothorax is categorized as either traumatic or spontaneous. Traumatic pneumothorax is more common and occurs as a result of damage to the lung parenchyma or chest wall. Treatment of traumatic pneumothorax is typically supportive, with intermittent or continuous aspiration of air, oxygen supplementation, and resolution in 2 to 3 days time. Iatrogenic pulmonary damage, such as that associated with thoracocentesis or positive pressure ventilation, may also result in pneumothorax. (Source: Advances in Small Animal Medicine and Surgery)
Source: Advances in Small Animal Medicine and Surgery - March 1, 2014 Category: Veterinary Research Tags: Respiratory Medicine Source Type: research

An association between pulmonary hypertension and impaired lung function in infants with congenital diaphragmatic hernia
ConclusionsInfants with CDH and persistent PH demonstrate greater airspace overdistension with growth compared to those without. Therapies that modify disrupted pulmonary vascular and alveolar formation could potentially improve future care of these patients. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 1, 2014 Category: Respiratory Medicine Authors: Fiona Healy, Wei Lin, Rui Feng, Brian D. Hanna, Holly Hedrick, Howard B. Panitch Tags: Original Article: Neonatal Lung Disease Source Type: research

Effect of continuous hypothermic machine perfusion transport system (Airdrive(TM)) on canine kidney preservation.
CONCLUSION: With prolonged storage time, the effect of continuous hypothermic machine perfusion transport system is better than that of common cold preservation on canine kidney. PMID: 24622443 [PubMed - in process] (Source: Chinese Medical Journal)
Source: Chinese Medical Journal - March 1, 2014 Category: Journals (General) Authors: Hu X, Xue W, Zhang Q, Wang W, Zhang J, Zhang X Tags: Chin Med J (Engl) Source Type: research

Intratracheal administration of umbilical cord blood-derived mesenchymal stem cells in a patient with acute respiratory distress syndrome.
Abstract Umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) have been introduced as a possible therapy in acute lung injury and acute respiratory distress syndrome (ARDS). This case history is reported of a 59-yr-old man who was treated with MSCs in the course of ARDS and subsequent pulmonary fibrosis. He received a long period of mechanical ventilation and weaning proved difficult. On hospital day 114, he underwent the intratracheal administration of UCB-derived MSCs at a dose of 1 × 10(6)/kg. After cell infusion, an immediate improvement was shown in his mental status, his lung compliance (from 22....
Source: J Korean Med Sci - March 1, 2014 Category: Journals (General) Authors: Chang Y, Park SH, Huh JW, Lim CM, Koh Y, Hong SB Tags: J Korean Med Sci Source Type: research

Current status of intensive care units registered as critical care subspecialty training hospitals in Korea.
Abstract There is a lack of information on critical care in Korea. The aim of this study was to determine the current status of Korean intensive care units (ICUs), focusing on the organization, characteristics of admitted patients, and nurse and physician staffing. Critical care specialists in charge of all 105 critical care specialty training hospitals nationwide completed a questionnaire survey. Among the ICUs, 56.4% were located in or near the capital city. Only 38 ICUs (17.3%) had intensive care specialists with a 5-day work week. The average daytime nurse-to-patient ratio was 1:2.7. Elderly people ≥ 65 yr of...
Source: J Korean Med Sci - March 1, 2014 Category: Journals (General) Authors: Kwak SH, Jeong CW, Lee SH, Lee HJ, Koh Y Tags: J Korean Med Sci Source Type: research

Real‐time feedback for spatiotemporal field stabilization in MR systems
ConclusionFeedback field control is an effective means of eliminating dynamic field distortions in MR systems. Third‐order spatial control at an update time of 100 ms has proven sufficient to largely eliminate thermal and breathing effects in brain imaging at 7 Tesla. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - March 1, 2014 Category: Radiology Authors: Yolanda Duerst, Bertram J. Wilm, Benjamin E. Dietrich, S. Johanna Vannesjo, Christoph Barmet, Thomas Schmid, David O. Brunner, Klaas P. Pruessmann Tags: Full Paper Source Type: research

An adolescent with graves' disease and thymic hyperplasia.
Abstract A 14-year-old female presented to our hospital for a second opinion regarding a recent diagnosis of Graves' disease and a mediastinal mass. Four months prior to presentation, the patient developed difficulty with concentration. Historically she had been an A/B student; however, her school performance worsened suddenly, and she almost failed the eighth grade. One month later, she began complaining of increased sweating, diarrhea, difficulty with balance, jitteriness, and difficulty sitting still. During the previous 2 months, she had an increased appetite along with a 10-lb weight gain, increased hair loss,...
Source: Pediatric Annals - March 1, 2014 Category: Pediatrics Authors: D'Souza S, Patel P, Hageman JR, Deplewski D Tags: Pediatr Ann Source Type: research

Hyperinsulinism in a neonate.
Abstract A male patient was born small for gestational age (SGA) at 33 weeks with a birth weight of 1,663 grams (< 10th percentile) and length 43 cm (10th percentile) to a 38-year-old G5P4 mother by cesarean section due to non-reassuring fetal heart tones. Prior to delivery, his mother experienced decreased fetal movement and decelerations. At birth, he was initially well-appearing and vigorous, with Apgar scores of 7 and 8 at 1 and 5 minutes, respectively. The physical examination was unremarkable - no skin findings, no facial anomalies, good tone, and the anterior fontanelle was soft and flat. The placenta, al...
Source: Pediatric Annals - March 1, 2014 Category: Pediatrics Authors: Blanco M, Khan O, Stanley K, Hageman JR, Greeley SA Tags: Pediatr Ann Source Type: research

Elimination of A-type inclusion formation enhances cowpox virus replication in mice: Implications for orthopoxvirus evolution.
Abstract Some orthopoxviruses including cowpox virus embed virus particles in dense bodies, comprised of the A-type inclusion (ATI) protein, which may provide long-term environmental protection. This strategy could be beneficial if the host population is sparse or spread is inefficient or indirect. However, the formation of ATI may be neutral or disadvantageous for orthopoxviruses that rely on direct respiratory spread. Disrupted ATI open reading frames in orthopoxviruses such as variola virus, the agent of smallpox, and monkeypox virus suggests that loss of this feature provided positive selection. To test this hy...
Source: Virology - March 1, 2014 Category: Virology Authors: Kastenmayer RJ, Maruri-Avidal L, Americo JL, Earl PL, Weisberg AS, Moss B Tags: Virology Source Type: research

Protection from SARS coronavirus conferred by live measles vaccine expressing the spike glycoprotein.
Abstract The recent identification of a novel human coronavirus responsible of a SARS-like illness in the Middle-East a decade after the SARS pandemic, demonstrates that reemergence of a SARS-like coronavirus from an animal reservoir remains a credible threat. Because SARS is contracted by aerosolized contamination of the respiratory tract, a vaccine inducing mucosal long-term protection would be an asset to control new epidemics. To this aim, we generated live attenuated recombinant measles vaccine (MV) candidates expressing either the membrane-anchored SARS-CoV spike (S) protein or its secreted soluble ectodomain...
Source: Virology - March 1, 2014 Category: Virology Authors: Escriou N, Callendret B, Lorin V, Combredet C, Marianneau P, Février M, Tangy F Tags: Virology Source Type: research

Bursts of high frequency repetitive transcranial magnetic stimulation suppress ongoing seizures and augment lorazepam efficacy in a rat kainate status epilepticus model
Status epilepticus (SE) is a condition of prolonged, and often drug-resistant, seizures. Successful pharmacologic SE treatment often leads to sedation and respiratory depression. A non-pharmacologic and non-sedating SE therapeutic thus remains an important unmet need. Repetitive transcranial magnetic stimulation (rTMS) is emerging as a means to suppress seizures, but has not been extensively studies in SE models. (Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation)
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - March 1, 2014 Category: Neurology Authors: Roman Gersner, Sameer C. Dhamne, Abraham Zangen, Alvaro Pascual-Leone, Alexander Rotenberg Tags: Abstracts Presented at NYC Neuromodulation 2013 Source Type: research

A new framework for interleaved scanning in cardiovascular MR: Application to image‐based respiratory motion correction in coronary MR angiography
ConclusionThe usefulness of the proposed scan interleaving framework was demonstrated for image‐based respiratory motion correction. It facilitated more direct comparisons of image navigator acquisitions with different k‐space trajectories. Furthermore, we could demonstrate that spiral and Cartesian EPI navigators may be particularly suitable for image‐based motion correction, as they provide improved motion correction and high navigator apparent signal‐to‐noise ratio while spending very little magnetization, thereby minimizing saturation effects. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Mag...
Source: Magnetic Resonance in Medicine - March 1, 2014 Category: Radiology Authors: Markus Henningsson, Giel Mens, Peter Koken, Jouke Smink, Rene M. Botnar Tags: Note Source Type: research

Effects of acute hypoxia on cerebrovascular responses to carbon dioxide
This study tested the hypothesis that acute hypoxia attenuates PCO2‐mediated regulation of CBF to help maintain cerebral O2 homeostasis. Eight subjects performed three randomly assigned respiratory interventions following a resting baseline period: 1) normoxia (21% O2), 2) hypoxia (12% O2) and 3) hypoxia with willful restraint of the respiratory chemoreflex. During each intervention, 0, 2.0, 3.5 or 5.0% CO2 were sequentially added (8 min stages) to inspired gas mixtures to assess changes in steady‐state cerebrovascular CO2 reactivity and dCA. During normoxia, the addition of CO2 increased internal carotid artery (ICA) ...
Source: Experimental Physiology - March 1, 2014 Category: Physiology Authors: Shigehiko Ogoh, Hidehiro Nakahara, Shinya Ueda, Kazunobu Okazaki, Manabu Shibasaki, Andrew W. Subudhi, Tadayoshi Miyamoto Tags: Research Paper Source Type: research

Superior Vena Cava Syndrome Developing in Non-small Cell Lung Cancer.
CONCLUSIONS: This case illustrates that given the rarity of the number of patients with NSCLC who develop SVCS, prompt recognition and treatment is vital in leading to successful improvement in symptoms and reduction in O2 requirements.Reference #1: Hunter, W. The history of an aneurysm of the aorta with some remarks on aneurysms in general. Med ObsSoc Phys Lond. 1757:323Reference #2: Rice TW et al. The superior vena cava syndrome: clinical characteristics and evolving etiology. Medicine 2006,85:37-42Reference #3: Higdon ML et al. Treatment of oncologic emergencies. Am Fam Physician. 2006,74:1873-80DISCLOSURE: The followin...
Source: American Family Physician - March 1, 2014 Category: Primary Care Authors: Rajagopal A, Simala J Tags: Chest Source Type: research

Malignant transformation of recurrent respiratory papillomatosis: atypical presentation as right mainstem bronchus occlusion.
CONCLUSIONS: Radiographic surveillance for pulmonary involvement is appropriate in patients with severe long-standing RRP.Reference #1: Venkatesan NN, Pine HS, Underbrink MP. Recurrent respiratory papillomatosis. Otolaryngol Clin North Am. 2012 Jun;45(3):671-94.Reference #2: Frauenfelder T, Marincek B, Wildermuth S. Pulmonary spread of recurrent respiratory papillomatosis with malignant transformation: CT-findings and airflow simulation. Eur J Radiol Extra 2005;56:11-6.Reference #3: Cook JR, Hill DA, Humphrey PA, Pfeifer JD, El-Mofty SK. Squamous cell carcinoma arising in recurrent respiratory papillomatosis with pulmonary...
Source: Radiologic Clinics of North America - March 1, 2014 Category: Radiology Authors: Siddiqi T, Assar S, Lougee K, Knepler J Tags: Chest Source Type: research

Nephrocalcinosis in pre-term neonates: A study of incidence and risk factors.
The objective of this study was to determine the incidence and risk factors of nephrocalcinosis (NC) in pre-term neonates in the neonatal intensive care unit (NICU) at the Al-Minya University, Egypt. The study included 97 pre-term neonates with a gestational age 34 weeks. Data on duration of hospitalization, sex, gestation, birth weight, family history of renal stone, need for respiratory support, intake of calcium and use of total parenteral nutrition (TPN) and nephrotoxic drugs were collected. Blood urea nitrogen, serum creatinine, sodium, potassium, calcium and phosphate were measured within the first week of life and a...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2014 Category: Urology & Nephrology Authors: Mohamed GB, Ibrahiem MA, Abdel Hameed WM Tags: Saudi J Kidney Dis Transpl Source Type: research

Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing
Abstract In the normal quiescent vasculature, only 0.01% of endothelial cells (ECs) are proliferating. However, this proportion increases dramatically following the angiogenic switch during tumor growth or wound healing. Recent evidence suggests that this angiogenic switch is accompanied by a metabolic switch. Here, we show that proliferating ECs increasingly depend on mitochondrial oxidative phosphorylation (OxPhos) for their increased energy demand. Under growth conditions, ECs consume three times more oxygen than quiescent ECs and work close to their respiratory limit. The increased utilization of the proton motif force...
Source: EMBO Molecular Medicine - March 1, 2014 Category: Molecular Biology Authors: Oliver Coutelle, Hue‐Tran Hornig‐Do, Axel Witt, Maria Andree, Lars M Schiffmann, Michael Piekarek, Kerstin Brinkmann, Jens M Seeger, Maxim Liwschitz, Satomi Miwa, Michael Hallek, Martin Krönke, Aleksandra Trifunovic, Sabine A Eming, Rudolf J Wiesner, Tags: Research Article Source Type: research

Pleural effusion in patients with end-stage liver disease who are candidates for transplant.
CONCLUSIONS: Preoperative pleural effusion is a common problem in patients who are candidates for a liver transplant. Most of these patients have right transudative pleural effusion. PMID: 24635814 [PubMed - in process] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 1, 2014 Category: Transplant Surgery Authors: Doğrul MI, Akçay S, Savaş Bozbaş S, Er Dedekargınoğlu B, Oner Eyüboğlu F, Moray G, Haberal M Tags: Exp Clin Transplant Source Type: research

Pathological findings of liver allografts evaluated at autopsy.
CONCLUSIONS: Our results emphasize that infections are the main cause of death and hepatic infarction is the main histopathologic findings among these 13 patients within the first year of transplant. We consider postmortem examination to have important role in determining the primary graft failure and other causes that increased mortality in liver transplant recipients. An autopsy can provide understanding of the main causes and cause of death. PMID: 24635808 [PubMed - in process] (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - March 1, 2014 Category: Transplant Surgery Authors: Ayva ES, Ozdemir BH, Tepeoğlu M, Haberal M Tags: Exp Clin Transplant Source Type: research

Embolization of pulmonary sequestration with Onyx: an unusual application.
We report a baby with intralobar pulmonary sequestration who was successfully treated with a new embolization agent, Onyx. A 1.5-month-old female infant was admitted to our hospital with sweating and fatigue. Telecardiography showed cardiomegaly, dextrocardia, and increased pulmonary vascular markings. In thoracic computerized tomography, pulmonary sequestration, right pulmonary hypoplasia, and large collateral arteries were seen. The collateral arteries were originating from the celiac trunk and aorta. Echocardiography revealed enlargement of the left atrium and ventricle and left ventricle systolic dysfunction. Angiograp...
Source: Turk Kardiyoloji Dernegi arsivi - March 1, 2014 Category: Cardiology Authors: Gürsu AH, Boyvat F, Varan B, Erdoğan I Tags: Turk Kardiyol Dern Ars Source Type: research

The Diversity of Young Adult Wheeze; a Cluster Analysis in a Longitudinal Birth Cohort
Conclusions & Clinical RelevanceYoung adult wheeze is diverse and can be classified into distinct clusters. More severe clusters merit attention and are associated with childhood onset, atopy, impaired lung function and in some, smoking. Smoking associated undiagnosed‐wheezers also merit recognition. Better understanding of young adult wheeze could facilitate better later adult respiratory health.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 1, 2014 Category: Allergy & Immunology Authors: Ramesh J Kurukulaaratchy, Hongmei Zhang, Abid Raza, Veeresh Patil, Wilfried Karmaus, Susan Ewart, S Hasan Arshad Tags: Original Article‐Asthma and Rhinitis Source Type: research

Noninvasive assessment of hepatic fibrosis in patients with chronic hepatitis B viral infection using magnetic resonance elastography.
CONCLUSION: MRE has a high technical success rate and excellent diagnostic accuracy for staging hepatic fibrosis in patients with chronic HBV infection. PMID: 24643284 [PubMed - in process] (Source: Korean J Radiol)
Source: Korean J Radiol - March 1, 2014 Category: Radiology Authors: Lee JE, Lee JM, Lee KB, Yoon JH, Shin CI, Han JK, Choi BI Tags: Korean J Radiol Source Type: research

Determinants of Noninvasive Ventilation Outcomes during an Episode of Acute Hypercapnic Respiratory Failure in Chronic Obstructive Pulmonary Disease: The Effects of Comorbidities and Causes of Respiratory Failure.
Conclusions. The most important determinants of NIV outcome in COPD patients are the presence of pneumonia and the level of serum albumin as an indicator of the patient nutritional status. PMID: 24563868 [PubMed - in process] (Source: Biomed Res)
Source: Biomed Res - February 28, 2014 Category: Research Authors: Pacilli AM, Valentini I, Carbonara P, Marchetti A, Nava S Tags: Biomed Res Int Source Type: research

Adolescent girls with emotional disorders have a lower end‐tidal CO2 and increased respiratory rate compared with healthy controls
This study investigates end‐tidal carbon dioxide (ETCO2), respiratory rate (RR), and heart rate variability (HRV) in adolescent girls with emotional disorders and healthy controls. ETCO2, RR, HRV, and ratings of emotional symptom severity were collected in adolescent female psychiatric patients with emotional disorders (n = 63) and healthy controls (n = 62). ETCO2 and RR differed significantly between patients and controls. ETCO2, HR, and HRV were significant independent predictors of group status, that is, clinical or healthy, while RR was not. ETCO2 and RR were significantly related to emotional symptom severit...
Source: Psychophysiology - February 28, 2014 Category: Neurology Authors: Eva Henje Blom, Eva Serlachius, Margaret A. Chesney, Erik M. G. Olsson Tags: Original Article Source Type: research

[Comment] Safer countries through global health security
Countries around the world face a perfect storm of converging threats that might substantially increase the risk from infectious disease epidemics, despite improvements in technologies, communication, and some health systems. New pathogens emerge each year, some of which have high mortality and the potential for efficient transmission—eg, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome coronavirus, and avian influenza A H7N9. Existing pathogens are becoming resistant to available antibiotics and several are now resistant to virtually all available treatment. (Source: LANCET)
Source: LANCET - February 28, 2014 Category: Journals (General) Authors: Thomas R Frieden, Jordan W Tappero, Scott F Dowell, Nguyen T Hien, Florence D Guillaume, Jane R Aceng Tags: Comment Source Type: research

Antinociceptive and selected physiological effects of morphine and xylazine on tiletamine‐zolazepam anesthesia in llamas
Conclusion and clinical relevanceThe combination of morphine (0.5 mg kg−1) and xylazine (0.15 mg kg−1) increased the duration of antinociception compared with xylazine alone, in TZ‐anesthetized llamas. Treatments X, M and MX were associated with hypoxemia (PaO2 < 60 mmHg). (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - February 28, 2014 Category: Veterinary Research Authors: Reza Seddighi, Sarah B Elliot, Brian K Whitlock, Christine M Egger, Thomas J Doherty Tags: Research Paper Source Type: research

Effectiveness of prediction equations in estimating energy expenditure sample of brazilian and spanish women with excess body weight.
Conclusion: The equations proposed by FAO/WHO/ ONU, Harris-Benedict, Shofield and Henry & Rees were adequate to estimate the EE in a sample of Brazilian and Spanish women with excess body weight. The other equations underestimated the EE. PMID: 24558992 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - February 28, 2014 Category: Nutrition Authors: Lopes Rosado E, Santiago de Brito R, Bressan J, Martínez Hernández JA Tags: Nutr Hosp Source Type: research

Cohort Profile: The Housing Regeneration and Health Study
A cohort comprising residents of a housing regeneration and health programme was created from routinely collected data using a system which allows us to anonymously link housing data to individuals and their health. The regeneration programme incorporating four rolling work packages runs from 2009 to 2014. The main intervention cohort we describe here contains the 18 312 residents of 9051 residences at baseline. The cohort will be followed continuously through routine health data (demographics, mortality, hospital admissions and general practitioner records including prescriptions) with periodic updates of housing regenera...
Source: International Journal of Epidemiology - February 28, 2014 Category: Epidemiology Authors: Rodgers, S. E., Heaven, M., Lacey, A., Poortinga, W., Dunstan, F. D., Jones, K. H., Palmer, S. R., Phillips, C. J., Smith, R., John, A., Davies, G. A., Lyons, R. A. Tags: Cohort Profiles Source Type: research

Effectiveness of Nebulized Beclomethasone in Preventing Viral Wheezing: An RCT
Viral wheezing is common in preschool-aged children. The efficacy of inhaled steroids in preventing viral wheezing is debated. Despite this debate, nebulized beclomethasone is widely prescribed (particularly in a few countries) to children with upper respiratory tract infections. Findings from this study confirm that inhaled steroids are not effective in preventing viral wheezing. Moreover, no differences were found in the persistence of symptoms (eg, runny nose, sore throat) or in the parental perception of asthma-like symptom severity. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 28, 2014 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness
Quantitative real-time polymerase chain reaction allows sensitive detection of respiratory viruses. The clinical significance of detection of specific viruses is not fully understood, however, and several viruses have been detected in the respiratory tract of asymptomatic children. Our results indicate that quantitative real-time polymerase chain reaction is limited at distinguishing acute infection from detection in asymptomatic children for rhinovirus, bocavirus, adenovirus, enterovirus, and coronavirus. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - February 28, 2014 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Effectiveness of Nebulized Beclomethasone in Preventing Viral Wheezing: An RCT
CONCLUSIONS: The findings from this study confirm that inhaled steroids are not effective in preventing recurrence of viral wheezing. Moreover, no benefits were found in reducing symptoms of respiratory tract infections. (Source: PEDIATRICS)
Source: PEDIATRICS - February 28, 2014 Category: Pediatrics Authors: Clavenna, A., Sequi, M., Cartabia, M., Fortinguerra, F., Borghi, M., Bonati, M., on Behalf of the ENBe Study Group Tags: Article Source Type: research

Clinical Utility of PCR for Common Viruses in Acute Respiratory Illness
CONCLUSIONS: qPCR detection of respiratory syncytial virus, metapneumovirus, or parainfluenza viruses in children with ARI is likely to be causative of disease; detection of several other respiratory viruses must be interpreted with caution due to high detection rates in asymptomatic children. (Source: PEDIATRICS)
Source: PEDIATRICS - February 28, 2014 Category: Pediatrics Authors: Rhedin, S., Lindstrand, A., Rotzen-Ostlund, M., Tolfvenstam, T., Ohrmalm, L., Rinder, M. R., Zweygberg-Wirgart, B., Ortqvist, A., Henriques-Normark, B., Broliden, K., Naucler, P. Tags: Article Source Type: research

Status Epilepticus: A Possible Association With Human Metapneumovirus Infection
In this report, we describe 2 toddlers with hMPV infection who presented in status epilepticus and went on to develop respiratory failure. Both patients fully recovered over 2 weeks and were discharged from the hospital with no sequelae. The association between hMPV infection and neurologic complications is increasingly being reported in the literature. Clinicians should be aware of these uncommon manifestations of a common respiratory pathogen and consider testing for hMPV when managing pediatric patients who present with unexplained status epilepticus or encephalitis. (Source: PEDIATRICS)
Source: PEDIATRICS - February 28, 2014 Category: Pediatrics Authors: Webster, D. L., Gardner, A. H., Dye, T. J., Chima, R. S. Tags: Case Report Source Type: research

Relationship between CT air trapping criteria and lung function in small airway impairment quantification
Conclusion: Among all CT criteria, all correlating with small airway obstruction on SBNT, E/I MLD was the most suitable criterion for its expression in asymptomatic subjects with mild small airway obstructionTrial registration: Registered at, identifier: NCT01230879. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 28, 2014 Category: Respiratory Medicine Authors: Sébastien BommartGrégory MarinArnaud BourdinNicolas MolinariFrançois KleinMaurice HayotIsabelle VachierPascal ChanezJacques MercierHélène Vernhet-Kovacsik Source Type: research

Prevention and Control of Haemophilus influenzae Type b Disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP).
This report compiles and summarizes all recommendations from CDC's Advisory Committee on Immunization Practices (ACIP) regarding prevention and control of Haemophilus influenzae type b (Hib) disease in the United States. As a comprehensive summary of previously published recommendations, this report does not contain any new recommendations; it is intended for use by clinicians, public health officials, vaccination providers, and immunization program personnel as a resource. ACIP recommends routine vaccination with a licensed conjugate Hib vaccine for infants aged 2 through 6 months (2 or 3 doses, depending on vaccine produ...
Source: MMWR Recomm Rep - February 28, 2014 Category: Epidemiology Authors: Briere EC, Rubin L, Moro PL, Cohn A, Clark T, Messonnier N, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, CDC Tags: MMWR Recomm Rep Source Type: research

Bleomycin Delivery by Osmotic Mini-Pump: Similarity to Human Scleroderma Interstitial Lung Disease.
Abstract The Interstitial Lung Diseases (ILD) include a large number of chronic, progressive, irreversible respiratory disorders involving pulmonary fibrosis, the most common of which are idiopathic pulmonary fibrosis (IPF) and scleroderma lung disease (SSc ILD). Because bleomycin causes lung fibrosis when used in cancer chemotherapy, it is used to model human ILD in rodents. In most studies, bleomycin has been delivered directly into the lung by intratracheal or intraoral administration. Here we have compared the effects in mice of bleomycin delivered directly into the lungs (Direct Model) or systemically using os...
Source: Am J Physiol Lung Ce... - February 28, 2014 Category: Respiratory Medicine Authors: Lee R, Reese C, Bonner M, Tourkina E, Hajdu Z, Riemer EC, Silver RM, Visconti RP, Hoffman S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

c-Kit immunoexpression delineates a putative endothelial progenitor cell population in developing human lungs.
This study also suggests the potential involvement of c-kit signaling in lung vascular development. PMID: 24583878 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - February 28, 2014 Category: Respiratory Medicine Authors: Suzuki T, Suzuki S, Fujino N, Ota C, Yamada M, Suzuki T, Yamaya M, Kondo T, Kubo H Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Current Understandings and Perspectives on Non-Cancer Health Effects of Benzene: A Global Concern.
CONCLUSION: Chronic diseases have become a health burden of global dimension with special emphasis in regions with poor monitoring over contents of benzene in petrochemicals. Benzene is a well known carcinogen of blood and its components, but the concern of benzene exposure is more than carcinogenicity of blood components and should be evaluated in both epidemiologic and experimental studies. Aspect of interactions and mechanism of toxicity in relation to human general health problems especially endocrine disturbances with particular reference to diabetes, breast and lung cancers should be followed up. PMID: 24589379 [...
Source: Toxicology and Applied Pharmacology - February 28, 2014 Category: Toxicology Authors: Bahadar H, Mostafalou S, Abdollahi M Tags: Toxicol Appl Pharmacol Source Type: research

Eoetvoesia caeni gen. nov., sp. nov., isolated from an activated sludge system treating coke plant effluent.
Abstract A new bacterium, PB3-7BT, was isolated on phenol-supplemented inorganic growth medium from a laboratory-scale wastewater purification system that treated coke plant effluent. The 16S rRNA gene sequence analysis revealed that strain PB3-7BT belonged to the family Alcaligenaceae and possessed the highest pairwise similarity values to Parapusillimonas granuli LMG 24012T (97.5%), Candidimonas bauzanensis DSM 22805T (97.3%) and Pusillimonas noertemannii DSM 10065T (97.2%). Strain PB3-7BT was rod-shaped, motile, oxidase and catalase positive. The predominant fatty acids were C16:0 (38.8%), cycloC17:0 (20.7%), cy...
Source: International Journal of Systematic and Evolutionary Microbiology - February 28, 2014 Category: Microbiology Authors: Felfoldi T, Vengring A, Keki Z, Marialigeti K, Schumann P, Toth EM Tags: Int J Syst Evol Microbiol Source Type: research

Xenophilus arseniciresistens sp. nov., an arsenite-resistant bacterium isolated from soil.
Abstract A Gram-negative, aerobic, motile, rod-shaped, arsenite [As(III)]-resistant bacterium, designated as strain YW8T, was isolated from agricultural soil. The 16S rDNA sequence analysis showed over 97 % sequence similarity to strains of the environmental species Xenophilus azovorans, Xenophilus aerolatus, Simplicispira metamorpha, Variovorax soli, and Xylophilus ampelinus. However, the phylogenetic tree indicated that strain YW8T formed a separate clade from Xenophilus azovorans. DNA-DNA hybridization experiments showed that the DNA-DNA relatedness values between strain YW8T and its closest phylogenetic neighbo...
Source: International Journal of Systematic and Evolutionary Microbiology - February 28, 2014 Category: Microbiology Authors: Li QF, Sun LN, Kwon SW, Chen Q, He J, Li SP, Zhang J Tags: Int J Syst Evol Microbiol Source Type: research