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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.

The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus
To determine the 28 day mortality of patients with ARDS in relation to body mass index (BMI) and presence diabetes mellitus (DM). (Source: Heart and Lung)
Source: Heart and Lung - July 23, 2015 Category: Intensive Care Authors: Ayman O. Soubani, Wei Chen, Hyejeong Jang Source Type: research

Pro-inflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension: Role of MIF/CD74 Complex.
CONCLUSIONS: We report here that CD74 and MIF are markedly increased and activated in iPAH patients, contributing to the abnormal pro-inflammatory phenotype of pulmonary ECs in iPAH. PMID: 26203495 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2015 Category: Respiratory Medicine Authors: Le Hiress M, Tu L, Ricard N, Phan C, Thuillet R, Fadel E, Dorfmüller P, Montani D, de Man F, Humbert M, Huertas A, Guignabert C Tags: Am J Respir Crit Care Med Source Type: research

Mitochondrial E3 Ubiquitin Protein Ligase 1 Mediates Cigarette Smoke-Induced Endothelial Cell Death and Dysfunction.
Abstract By virtue of critical roles of Akt in vascular endothelial cell (EC) survival and function, cigarette smoke-induced Akt reduction may contribute to EC death and dysfunction in smokers' lungs. One of the negative Akt regulatory mechanisms is K48-linked Akt ubiquitination and subsequent proteasomal degradation. Here, we assessed the involvement of mitochondrial E3 ubiquitin protein ligase 1 (MUL1), recently revealed as a novel Akt ubiquitin E3 ligase, in cigarette smoke-induced Akt ubiquitination and its contribution to pulmonary EC death and dysfunction. In human lung microvascular endothelial cells (HLMVEC...
Source: Am J Respir Cell Mol... - July 23, 2015 Category: Respiratory Medicine Authors: Kim SY, Kim HJ, Park MK, Huh JW, Park HY, Ha SY, Shin JH, Lee YS Tags: Am J Respir Cell Mol Biol Source Type: research

Targeted Type 2 Alveolar Cell Depletion Provides a Dynamic Functional Model for Lung Injury Repair.
Abstract Type 2 Alveolar Epithelial cells (AEC2) are regarded as the progenitor population of the alveolus responsible for injury repair and homeostatic maintenance. Depletion of this population is hypothesized to underlie various lung pathologies. Current models of lung injury rely on either uncontrolled, non-specific destruction of alveolar epithelia or targeted, non-titratable levels of fixed AEC2 ablation. We hypothesized that discrete levels of AEC2 ablation would trigger stereotypical and informative patterns of repair. To this end, we created a transgenic mouse model in which the Surfactant Protein-C promote...
Source: Am J Respir Cell Mol... - July 23, 2015 Category: Respiratory Medicine Authors: Garcia O, Hiatt MJ, Lundin A, Lee J, Reddy R, Navarro S, Kikuchi A, Driscoll B Tags: Am J Respir Cell Mol Biol Source Type: research

Ozone-Induced Type 2 Immunity in Nasal Airways: Development and Lymphoid Cell Dependence in Mice.
Abstract Inhalation exposures to ozone commonly encountered in photochemical smog, cause airway injury and inflammation. Elevated ambient ozone concentrations have been epidemiologically associated with nasal airway activation of neutrophils and eosinophils. In the present study, we elucidated the temporal onset and lymphoid cell dependency of eosinophilic rhinitis and associated epithelial changes in mice repeatedly exposed to ozone. Lymphoid-cell-sufficient, C57BL/6 mice were exposed to 0 or 0.5 ppm ozone for 1, 2, 4, or 9 consecutive weekdays (4 h/day). Lymphoid-cell-deficient, Rag2(-/-)Il2rg(-/-) mice were simi...
Source: Am J Respir Cell Mol... - July 23, 2015 Category: Respiratory Medicine Authors: Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR Tags: Am J Respir Cell Mol Biol Source Type: research

Crowded Respiratory Proteins That Function as a Single Unit [Enzymology]
Electron transfer reactions among three prominent colored proteins in intact cells of Acidithiobacillus ferrooxidans were monitored using an integrating cavity absorption meter that permitted the acquisition of accurate absorbance data in suspensions of cells that scattered light. The concentrations of proteins in the periplasmic space were estimated to be 350 and 25 mg/ml for rusticyanin and cytochrome c, respectively; cytochrome a was present as one molecule for every 91 nm2 in the cytoplasmic membrane. All three proteins were rapidly reduced to the same relative extent when suspensions of live bacteria were mixed with d...
Source: Journal of Biological Chemistry - July 23, 2015 Category: Chemistry Authors: Li, T.-F., Painter, R. G., Ban, B., Blake, R. C. Tags: Bioenergetics Source Type: research

{alpha}-Synuclein Regulates VDAC Permeability [Molecular Bases of Disease]
Participation of the small, intrinsically disordered protein α-synuclein (α-syn) in Parkinson disease (PD) pathogenesis has been well documented. Although recent research demonstrates the involvement of α-syn in mitochondrial dysfunction in neurodegeneration and suggests direct interaction of α-syn with mitochondria, the molecular mechanism(s) of α-syn toxicity and its effect on neuronal mitochondria remain vague. Here we report that at nanomolar concentrations, α-syn reversibly blocks the voltage-dependent anion channel (VDAC), the major channel of the mitochondrial outer membrane that controls most of the metabolit...
Source: Journal of Biological Chemistry - July 23, 2015 Category: Chemistry Authors: Rostovtseva, T. K., Gurnev, P. A., Protchenko, O., Hoogerheide, D. P., Yap, T. L., Philpott, C. C., Lee, J. C., Bezrukov, S. M. Tags: Molecular Biophysics Source Type: research

Respiratory function of the plastron in the aquatic bug, Aphelocheirus aestivalis (Hemiptera, Aphelocheiridae) [RESEARCH ARTICLE]
Roger S. Seymour, Karl K. Jones, and Stefan K. HetzThe river bug Aphelocheirus aestivalis is a 40 mg aquatic insect that, as an adult, relies totally on an incompressible physical gill to exchange respiratory gases with the water. The gill (called a ‘plastron’) consists of a stationary layer of air held in place on the body surface by millions of tiny hairs that support a permanent air-water interface, so that the insect never has to renew the gas at the water's surface. The volume of air in the plastron is extremely small (0.14 mm3), under slightly negative pressure, and connected to the gas-filled tracheal sy...
Source: Journal of Experimental Biology - July 23, 2015 Category: Biology Authors: Seymour, R. S., Jones, K. K., Hetz, S. K. Tags: RESEARCH ARTICLE Source Type: research

Concentrated NSAID for large animals
Bayer Animal Health has extended its range of products for farm animals with the addition of Dinalgen, an injectable NSAID that is licensed for use in cattle, pigs and horses. The product contains ketoprofen, available as a 150 mg/ml solution for injection. The company claims that the more concentrated format allows the product to provide ‘the smallest dose, fast relief NSAID currently available for cattle in the UK’. In cattle, the product is licensed for the reduction of inflammation and pain associated with lameness, postpartum and musculoskeletal disorders; reduction of fever associated with bovine res...
Source: Veterinary Record - July 23, 2015 Category: Veterinary Research Tags: Products and Services Source Type: research

European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014
Enterovirus D68 (EV-D68), formerly classified as rhinovirus 87 (RV-87) [14], has a mixture of enterovirus (EV) and rhinovirus (RV) features and can induce severe respiratory symptoms, mostly in children [15,16]. In addition, it has been detected in respiratory samples from patients who developed acute flaccid paralysis (AFP) or acute flaccid myelitis [12], but no definite link between EV-D68 infection and neurological disease has yet been established [13]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 23, 2015 Category: Virology Authors: Randy Poelman, Isabelle Schuffenecker, Coretta van Leer-Buter, Laurence Josset, Hubert G.M. Niesters, Bruno Lina, on behalf of the ESCV-ECDC EV-D68 study group Source Type: research

Prostanoids in Asthma and COPD: Actions, Dysregulation, and Therapeutic Opportunities.
Abstract Pathophysiologic gaps in the actions of currently available treatments for asthma and COPD include neutrophilic inflammation, airway remodeling, and alveolar destruction. All of these processes can be modulated by cyclic AMP-elevating prostaglandins E2 and I2 (also known as prostacyclin). These prostanoids have long been known to elicit bronchodilation and to protect against bronchoconstriction provoked by a variety of stimuli. Much less well known is their capacity to inhibit inflammatory responses involving activation of lymphocytes, eosinophils, and neutrophils as well as to attenuate epithelial injury ...
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Zaslona Z, Peters-Golden M Tags: Chest Source Type: research

Critical Care Transesophageal Echocardiography.
This article will review critical care TEE in reference to training, equipment, comparison to TTE, indications, safety, and standard views of critical care TEE. It should be considered a companion article to a recent two part series in CHEST that focused on advanced critical care TTE. Included with this article is an online supplement that has a representative series of critical care TEE images with clinical commentary. PMID: 26204465 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Mayo PH, Narasimhan M, Koenig S Tags: Chest Source Type: research

Pulmonary Hypertension in the setting of Hereditary Hemorrhagic Telangiectasia.
Conclusions: PH in patients with HHT occurs by different mechanisms, and there is a trend towards worse survival in patients that develop PH despite the mechanism. The equal predilection towards all subtypes of PH illustrates the necessity of RHC to clarify the hemodynamics. PMID: 26204445 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Lyle MA, Fenstad ER, McGoon MD, Frantz RP, Krowka MJ, Kane GC, Swanson KL Tags: Chest Source Type: research

A double-blind placebo-controlled study of the effects of olprinone, a specific phosphodiesterase-III inhibitor, for preventing postoperative atrial fibrillation in patients undergoing pulmonary resection for lung cancer.
CONCLUSIONS: Continuous infusion of olprinone during lung cancer surgery was safe and reduced the incidence of postoperative atrial fibrillation following pulmonary resection in patients with elevated preoperative BNP levels. Trial Registration: JPRN-UMIN2404. PMID: 26204331 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Nojiri T, Yamamoto K, Maeda H, Takeuchi Y, Ose N, Susaki Y, Inoue M, Okumura M Tags: Chest Source Type: research

Association of psychological disorders with 30-day readmission rates in patients with Chronic Obstructive Pulmonary Disease.
Conclusion: Psychological disorders like depression, anxiety, psychosis, alcohol abuse and drug abuse are independently associated with higher all cause 30-day readmission rates for Medicare beneficiaries with COPD. PMID: 26204260 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Singh G, Zhang W, Kuo YF, Sharma G Tags: Chest Source Type: research

Risk stratification of patients with acute symptomatic pulmonary embolism based on presence or absence of lower extremity deep vein thrombosis: systematic review and meta-analysis.
Conclusions: In patients diagnosed with acute symptomatic PE, concomitant DVT was significantly associated with an increased risk of death within 30 days of PE diagnosis. PMID: 26204122 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Becattini C, Cohen AT, Agnelli G, Howard L, Castejón B, Trujillo-Santos J, Monreal M, Perrier A, Yusen RD, Jiménez D Tags: Chest Source Type: research

Pulseless oximetry: A preliminary evaluation.
Conclusions: Preliminary results in a small number of patients demonstrate that pulseless oximetry can be used to estimate arterial saturation with acceptable accuracy. Clinical Implications: A noninvasive oximeter that does not rely on pulsatile flow would be a valuable advance in assessing oxygenation in patients with LVADs, for whom the only current option is arterial puncture, which is painful, risks arterial injury, and only provides a snapshot evaluation of oxygenation. PMID: 26204107 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Aldrich TK, Gupta P, Stoy S, Carlese A, Goldstein DJ Tags: Chest Source Type: research

Novel Bedside Phonetic Evaluation to Identify Dysphagia and Aspiration Risk.
Conclusions: Abnormal phonation among intensive and intermediate care unit patients is associated with dysphagia and aspiration. Future investigative efforts should uncover the most effective combination of evaluations for accurate bedside detection of dysphagia and aspiration risk in a broad spectrum of patients. PMID: 26203916 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Festic E, Soto Soto J, Pitre LA, Leveton M, Ramsey DM, Freeman WD, Heckman MG, Lee AS Tags: Chest Source Type: research

Structural Brain Changes in Patients with Chronic Obstructive Pulmonary Disease.
Conclusions: COPD patients demonstrated gray matter decreases in brain areas relevant for the processing of dyspnea, fear, and antinociception. These structural brain changes were partly related to longer disease duration and greater disease-specific fears, which might contribute to a less favorable course of the disease. PMID: 26203911 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Esser RW, Stoeckel MC, Kirsten A, Watz H, Taube K, Lehmann K, Petersen S, Magnussen H, von Leupoldt A Tags: Chest Source Type: research

Validation of the IMPROVE Bleeding Risk Score.
Conclusions: The IMPROVE BRS calculated at admission predicts major bleeding in medical inpatients. This model may help assess relative risks of bleeding and VTE before chemoprophylaxis is administered. PMID: 26203792 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Hostler DC, Marx ES, Moores LK, Petteys S, Hostler JM, Mitchell JD, Holley PR, Collen JF, Foster B, Holley AB Tags: Chest Source Type: research

Interpretability of Change Scores in Measures of Balance in People with COPD.
Conclusion: Among COPD patients undergoing pulmonary rehabilitation, a change of 5 to 7 points for the BBS, 13 to 17 points for the BESTest and 19 points for the ABC scale is required to be both perceptible to patients and beyond measurement error. PMID: 26203790 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Beauchamp MK, Harrison SL, Goldstein RS, Brooks D Tags: Chest Source Type: research

Outcomes and prognostic features of patients with influenza requiring hospitalization and receiving early antiviral therapy: A Prospective Multicenter-Cohort Study.
Conclusions: Among the prognostic factors, malnutrition and pneumonia are amenable to medical intervention. There is an opportunity to improve empiric therapy for patients with HCAP and influenza. Trial registration: Japan Medical Association Center for Clinical Trials JMA-IIA00123. PMID: 26203671 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Maruyama T, Fujisawa T, Suga S, Nakamura H, Nagao M, Taniguchi K, Tsutsui K, Ihara T, Niederman MS Tags: Chest Source Type: research

Changing Epidemiology of the Respiratory Bacteriology of Patients with Cystic Fibrosis.
Conclusions: The epidemiology of CF pathogens continues to change. The causes of these observations are most likely multifactorial and include improvements in clinical care and infection prevention and control. Data from this study will be useful to evaluate the impact of new therapies on CF microbiology. PMID: 26203598 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 23, 2015 Category: Respiratory Medicine Authors: Salsgiver EL, Fink AK, Knapp EA, LiPuma JJ, Olivier KN, Marshall BC, Saiman L Tags: Chest Source Type: research

The Utility of the Swine Model to Assess Biological Rhythms and Their Characteristics during Different Stages of Residence in a Simulated Intensive Care Unit: A Pilot Study.
Abstract The purpose of this pilot study was to explore the utility of the mammalian swine model under simulated intensive care unit (sICU) conditions and mechanical ventilation (MV) for assessment of the trajectory of circadian rhythms of sedation requirement, core body temperature (CBT), pulmonary mechanics (PM) and gas exchange (GE). Data were collected prospectively with an observational time-series design to describe and compare circadian rhythms of selected study variables in four swine mechanically ventilated for up to seven consecutive days. We derived the circadian (total variance explained by rhythms of ...
Source: Chronobiology International - July 23, 2015 Category: Biology Authors: Leyden KN, Hanneman SK, Padhye NS, Smolensky MH, Kang DH, Chow DS Tags: Chronobiol Int Source Type: research

Drug-Related Pneumonitis During Mammalian Target of Rapamycin Inhibitor Therapy: Radiographic Pattern-Based Approach in Waldenström Macroglobulinemia as a Paradigm.
CONCLUSION: Drug-related pneumonitis was noted on CT in 58% of Waldenström macroglobulinemia patients treated with mTOR inhibitor therapy. Most common findings were bilateral GGOs and reticular opacities, with or without consolidation, in peripheral and lower lungs, demonstrating COP and NSIP patterns. IMPLICATIONS FOR PRACTICE: The present study has demonstrated that drug-related pneumonitis during mammalian target of rapamycin (mTOR) inhibitor therapy is highly frequent, occurring in 58% of patients with Waldenström macroglobulinemia. The radiographic patterns of pneumonitis demonstrated cryptogenic organizing pneu...
Source: The Oncologist - July 23, 2015 Category: Cancer & Oncology Authors: Nishino M, Boswell EN, Hatabu H, Ghobrial IM, Ramaiya NH Tags: Oncologist Source Type: research

All-cause mortality and use of antithrombotics within 90 days of discharge in acutely ill medical patients.
Abstract Conflicting evidence exists regarding predictors of and antithrombotic benefit on mortality in hospitalised acutely-ill medical patients. We compared mortality risk within 90 days post-discharge among medically ill patients who did and did not receive antithrombotics. This retrospective claims analysis included patients ≥ 40 years with nonsurgical hospitalisation ≥ 2 days between 2005 and 2009 using the HealthCore Integrated Research Database. Antithrombotic use (i.e. anticoagulants and antiplatelets) post-discharge was captured from pharmacy claims. All-cause mortality was determined from Social S...
Source: Thrombosis and Haemostasis - July 23, 2015 Category: Hematology Authors: Mahan CE, Fields LE, Mills RM, Stephenson JJ, Fu AC, Fisher MD, Spyropoulos AC Tags: Thromb Haemost Source Type: research

PHiD-CV induces anti-Protein D antibodies but does not augment pulmonary clearance of nontypeable Haemophilus influenzae in mice.
CONCLUSIONS: PHiD-CV induced high levels of Protein D-specific antibodies, but did not augment pulmonary clearance of NTHi. We found no evidence to suggest that PHiD-CV will offer added benefit by preventing NTHi lung infection. PMID: 26212006 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 23, 2015 Category: Allergy & Immunology Authors: Siggins MK, Gill SK, Langford PR, Li Y, Ladhani SN, Tregoning JS Tags: Vaccine Source Type: research

Qipengyuania sediminis gen. nov., sp. nov., a novel member of the family Erythrobacteraceae, isolated from subterrestrial sediment.
Abstract A Gram-reaction-negative, non-motile, facultatively aerobic bacterium, designated as strain M1T, was isolated from a subterrestrial sediment sample of Qiangtang Basin in Qinghai-Tibetan plateau, China. The strain formed rough yellow colonies on R2A plates. Cells were ovals and short rods. Catalase test was positive and oxidase test was negative. Phylogenetic analyses based on 16S rRNA gene sequence indicated that the isolate belonged to the family Erythrobacteraceae and showed 96.2-96.4 % sequence similarities to the most closely relatives. Chemotaxonomic analysis revealed ubiquinone-10 (Q10) as the domina...
Source: International Journal of Systematic and Evolutionary Microbiology - July 23, 2015 Category: Microbiology Authors: Feng XM, Mo YX, Han L, Nogi Y, Zhu YH, Lv J Tags: Int J Syst Evol Microbiol Source Type: research

The role inflammatory response genes in obstructive sleep apnea syndrome: a review
Abstract Background Obstructive sleep apnea syndrome (OSAS) has a negative impact on health and behavior of millions of individuals worldwide. The pathogenesis of this disorder is a multifactorial process related to a variety of mechanisms, including selective activation of inflammatory response pathways. A number of inflammatory factors, such as IL-6, IL-8, and TNF-α, can be found in high concentrations in subjects with OSAS and may serve as biological markers of this disease. The concentration of these cytokines contributes to weight gain in patients with OSAS and can also modify the risk o...
Source: Sleep and Breathing - July 22, 2015 Category: Respiratory Medicine Source Type: research

Does Risk for Malnutrition in Patients Presenting With Fractures Predict Lower Quality Measures?
Conclusions: Patients treated for fractures and dislocations with any sign of malnutrition according to the MUST score were more than twice as likely to acquire some combination of infection, venous thromboembolism, respiratory failure, or other reason for readmission than those of normal nutritional status. Increasing levels of malnourishment corresponded with increasing risk for developing complications, whereas these complications were not necessarily associated with higher comorbidity. An assessment of a fracture patient's nutritional status should be considered a factor in evaluating risks related to fracture care. Th...
Source: Journal of Orthopaedic Trauma - July 22, 2015 Category: Orthopaedics Tags: Original Article Source Type: research

Use of Ambulatory Blood Pressure Monitoring for the Screening of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a frequent and underdiagnosed disease in hypertensive individuals who experience cardiovascular events. The aim of this study was to define the best model that combined the ambulatory blood pressure (BP) monitoring (ABPM), anthropometric, sociodemographic, and biological variables to identify moderate to severe OSA. A total of 105 ABPM‐confirmed hypertensive patients were evaluated using their clinical histories, blood analyses, ABPM, and home respiratory polygraphic results. A multivariate logistic regression analysis was performed to identify the significant variables. The best model in...
Source: The Journal of Clinical Hypertension - July 22, 2015 Category: Cardiology Authors: Gerard Torres, Manuel Sánchez‐de‐la‐Torre, Montserrat Martínez‐Alonso, Silvia Gómez, Oscar Sacristán, Jacint Cabau, Ferran Barbé Tags: Original Paper Source Type: research

Aerosol-Transmitted Infections—a New Consideration for Public Health and Infection Control Teams
This article reviews the evidence and characteristics of some of the accepted (tuberculosis, measles, chickenpox, whooping cough) and some of the more opportunistic (influenza, Clostridium difficile, norovirus) aerosol-transmitted infectious agents and outlines methods of detecting and quantifying transmission. (Source: Current Treatment Options in Infectious Diseases)
Source: Current Treatment Options in Infectious Diseases - July 22, 2015 Category: Infectious Diseases Source Type: research

Human Rhinovirus Types and Association with Respiratory Symptoms During the First Year of Life
Human rhinoviruses (HRV) cause respiratory infections and are associated with asthma development. We assessed HRV prevalence, types and association with respiratory symptoms in the first year of life in 20 unselected infants. HRV was detected in 32% of 825 weekly nasal swabs. Seventy-four different types of all three species were identified. HRV presence and related respiratory symptoms are highly heterogeneous. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Factors Affecting Staphylococcus aureus Colonization of the Nasopharynx in the First 6 Months of Life
Conclusions: SA colonization of NP begins very early in life and declines quickly. Methicillin-resistant SA has lower ability to maintain prolonged colonization status than methicillin-susceptible strains in the first 6 months of life. As the NP is colonized with other respiratory bacterial pathogens, the colonization with SA declines; however, this effect is stronger with Gram-negative bacteria, such as NTHI and MC. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

Household Food Insecurity is Associated with Respiratory Infections Among 6–11-Month Old Infants in Rural Ghana
Conclusion: Infants living in food insecure households are at an increased risk of respiratory tract morbidity. Interventions that address HHFI might be important to improve infant health in rural Ghana. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - July 22, 2015 Category: Infectious Diseases Tags: Original Studies Source Type: research

Stress index for positive end‐expiratory pressure titration in prone position: a piglet study
ConclusionsStress index can be used to titrate PEEP in the prone position in a surfactant‐depleted lung injury model. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - July 22, 2015 Category: Anesthesiology Authors: C. Pan, R. Tang, J. Xie, J. Xu, S. Liu, T. Yu, Y. Huang, F. Guo, Y. Yang, H. Qiu Tags: Original Article Source Type: research

Impact of acute exposure to WTC dust on ciliated and goblet cells in lungs of rats
Inhalation Toxicology, Ahead of Print. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - July 22, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Trends in mortality associated with opening of a full-capacity public emergency department at the main tertiary-level hospital in Tanzania
Conclusions The opening of a full-capacity ED in a tertiary-level hospital in sub-Saharan Africa was associated with a significant decrease in hospital mortality. This is despite a small, but significant, increase in the mortality rate in the ED as compared to that in the casualty room that it replaced. (Source: International Journal of Emergency Medicine)
Source: International Journal of Emergency Medicine - July 22, 2015 Category: Emergency Medicine Source Type: research

A maintenance hemodialysis diabetic patient with unexplained pulmonary and gastrointestinal involvement
Abstract A 50‐year‐old man with diabetes mellitus with diabetic retinopathy, peripheral neuropathy, hypertension, and end‐stage renal disease on maintenance hemodialysis, presented with persistent cough and hiccups, continued to be unwell with weight loss, poor appetite, and recurrent respiratory symptoms such as wheezing and cough. Whole body positron emission tomography‐computed tomography scan showed metabolically active lesions in liver, stomach/lesser sac, pancreas, and left sixth rib. As he had repeated bilateral transudative pleural effusion, left mini thoracotomy with pleural biopsy showed no evidence of gr...
Source: Hemodialysis International - July 22, 2015 Category: Hematology Authors: Anand Yuvaraj, Georgi Abraham, Abraham Kurien, Priyanka Koshy, Sanjeev Nair, Sudhakshina Ghosh Tags: Case Report Source Type: research

Severe liver failure due to influenza A infection in a hemodialysis patient
We report a case of a hemodialysis patient with influenza A infection who presented with severe hepatitis and liver failure, while his respiratory symptoms were mild. It is important to recognize influenza infection as an unexplained cause of hepatitis and liver failure. In our case, liver failure resolved with supportive treatment. (Source: Hemodialysis International)
Source: Hemodialysis International - July 22, 2015 Category: Hematology Authors: Maggie Ming Yee Mok, Vincent Chi Chung Cheng, Sing Leung Lui, Lorraine Pui Yuen Kwan, Gary Chi Wang Chan, Desmond Yat Hin Yap, Tak Mao Chan, Wai Kei Lo Tags: Case Report Source Type: research

Polymorphisms in genes of respiratory control and sudden infant death syndrome
Abstract Sudden infant death syndrome (SIDS) is a multifactorial syndrome and assumingly, among other mechanisms, a deficit in respiratory control leads to a failure of arousal and autoresuscitation when the child is challenged by a stressful homeostatic event, e.g., hypoxia. We hypothesize that genetic polymorphisms involved in respiratory control mediated in the medulla oblongata contribute to SIDS. Therefore, a total of 366 SIDS cases and 421 controls were genotyped for 48 SNPs in 41 candidate genes. Genotyping was performed using Fluidigm nanofluidic technology. Results were obtained for 356 SIDS and 406 contr...
Source: International Journal of Legal Medicine - July 22, 2015 Category: Medical Law Source Type: research

Asymmetric dimethylarginine contributes to airway nitric oxide deficiency in patients with COPD
ConclusionWhile circulating ADMA is higher, NO is lower in COPD and both show a strong correlation to the degree of airflow limitation. ADMA seems to be a possible new marker of prognosis of COPD and can be a novel therapeutic target for the treatment of COPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 22, 2015 Category: Respiratory Medicine Authors: Murat Aydin, Nejat Altintas, Levent Cem Mutlu, Bulent Bilir, Mustafa Oran, Feti Tülübaş, Birol Topçu, İsmail Tayfur, Volkan Küçükyalçin, Gizem Kaplan, Ahmet Gürel Tags: Original Article Source Type: research

Increased disease activity, severity and autoantibody positivity in rheumatoid arthritis patients with co‐existent bronchiectasis
ConclusionsIncreased levels of RA disease activity, severity and RA autoantibodies are demonstrated in patients with RA and co‐existent bronchiectasis compared to patients with RA alone, despite lower tobacco exposure. This study demonstrates that BRRA is a more severe systemic disease than RA alone. (Source: APLAR Journal of Rheumatology)
Source: APLAR Journal of Rheumatology - July 22, 2015 Category: Rheumatology Authors: Elizabeth Perry, Paul Eggleton, Anthony De Soyza, David Hutchinson, Clive Kelly Tags: Original Article Source Type: research

Disrupting differential hypoxia in peripheral veno-arterial extracorporeal membrane oxygenation
Patients receiving circulatory support with peripheral veno-arterial extracorporeal membrane oxygenation (VA-ECMO) are at risk of developing differential hypoxia. This phenomenon occurs in patients with concomitant respiratory failure. Poorly oxygenated blood, ejected into the ascending aorta from the left ventricle, competes with retrograde flow from the ECMO circuit, potentially causing myocardial and cerebral ischaemia. In a recent Critical Care article, Hou et al. use an animal model of peripheral VA-ECMO to study the physiology of differential hypoxia. Their findings support a dual circuit hypothesis, and show how dif...
Source: Critical Care - July 22, 2015 Category: Intensive Care Authors: Matthew Cove Source Type: research

A Drosophila model for mito-nuclear diseases generated by an incompatible interaction between tRNA and tRNA synthetase [RESEARCH ARTICLE]
ABSTRACT Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes, which produce the majority of cellular energy, requires the coordinated expression and translation of both mitochondrially and nuclear-encoded proteins. The joint genetic architecture of this system complicates the basis of mitochondrial diseases, and mutations both in mitochondrial DNA (mtDNA)- and nuclear-encoded genes have been implicated in mitochondrial dysfunction. Previously, in a set of mitochondrial-nuclear introgression strains, we characterized a dual genome epistas...
Source: DMM Disease Models and Mechanisms - July 22, 2015 Category: Biomedical Science Authors: Holmbeck, M. A., Donner, J. R., Villa-Cuesta, E., Rand, D. M. Tags: RESEARCH ARTICLE Source Type: research