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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women
Inhalation Toxicology, Volume 26, Issue 14, Page 861-865, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Infusing Interprofessional Education Into the Nursing Curriculum
Education for interprofessional collaboration should begin early in the nursing program with a gradual infusion of interprofessional competencies into the curriculum. The faculty developed an interprofessional education program for students in nursing, physical therapy, nutrition, and respiratory care, which focused on sharing knowledge about each discipline, developing respect and value for each other’s disciplines, and emphasizing techniques to improve communication and teamwork. (Source: Nurse Educator)
Source: Nurse Educator - December 4, 2014 Category: Nursing Tags: Feature Articles Source Type: research

Relationship between chronotropic incompetence and β-blockers based on changes in chronotropic response during cardiopulmonary exercise testing
Conclusions : An attenuated HR response may occur during the early stages of exercise. The HR response according to the presence or absence of β-blockers is clearly identifiable by comparing MCR-AT and MCR-Rc using the Wilkoff model. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 4, 2014 Category: Cardiology Source Type: research

Cervical lymph node metastasis as the first and only manifestation of prostatic adenocarcinoma
Publication date: Available online 4 December 2014 Source:Human Pathology: Case Reports Author(s): Tadashi Terada Prostatic carcinoma initially manifesting as only cervical lymph node swelling is a rare phenomenon. A 74-year-old man presented left cervical lymphadenopathy. An excisional biopsy was performed, and it was pathologically diagnosed as metastatic thyroid follicular carcinoma. However, imaging technique revealed no thyroid tumor or tumor in the body. The lymph node was re-examined 23months after the first diagnosis: it showed adenocarcinoma positive for PSA and PSAH. Biopsy of the prostate was performed immedia...
Source: Human Pathology: Case Reports - December 4, 2014 Category: Pathology Source Type: research

Sleep-related cortical arousals in adult subjects with negative polysomnography
Conclusions Age is the most important independent factor in predicting increasing AI in subjects with negative polysomnography. (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 4, 2014 Category: Respiratory Medicine Source Type: research

Validation of the new COPD assessment test translated into Thai in patients with chronic obstructive pulmonary disease
Conclusions: The official Thai CAT questionnaire has an acceptable reliability and validity. It can be expected to serve as a short and simple tool for assessment of the health status of Thai COPD patients. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 4, 2014 Category: Respiratory Medicine Authors: Chaicharn PothiratSumalee KiatboonsriCharoen Chuchottaworn Source Type: research

A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC)
Conclusion: First-line maintenance treatment with erlotinib compared to Best Supportive Care (BSC) can be considered cost-effective. In comparison to docetaxel, erlotinib is likely to be cost-effective in subsequent treatment regimens as well. The insights for bevacizumab are miscellaneous. There are findings that gefitinib is cost-effective in first- and second-line treatment, however, based on only two studies. The role of pharmacogenomic testing needs to be evaluated. Therefore, future research should improve the available evidence and consider pharmacogenomic profiling as specified by the European Medicines Agency. Upc...
Source: BMC Pulmonary Medicine - December 4, 2014 Category: Respiratory Medicine Authors: Ansgar LangeAnne PrenzlerMartin FrankHeiko GolponTobias WelteJ-Matthias von der Schulenburg Source Type: research

Poly (ADP-Ribose) Polymerase1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension
Publication date: Available online 3 December 2014 Source:Pulmonary Pharmacology & Therapeutics Author(s): Gurpreet Kaur , Neetu Singh , Poorella Lingeshwar , Hefazat H. Siddiqui , Kashif Hanif Recently, inhibition of poly (ADP-ribose) polymerase1 (PARP1) was shown to be protective in experimental pulmonary hypertension (PH) and prevented right ventricular hypertrophy (RVH) associated with it. However, molecular mechanism behind cardioprotection by PARP1 inhibition in PH still needs detailed exploration. Therefore, effect of inhibition of PARP1 on the right ventricle (RV) dysfunction was studied in monocrotaline ...
Source: Pulmonary Pharmacology and Therapeutics - December 4, 2014 Category: Respiratory Medicine Source Type: research

PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command
Publication date: 15 January 2015 Source:Respiratory Physiology & Neurobiology, Volume 206 Author(s): Céline Caravagna , Jorge Soliz Erythropoietin stimulation modulates the central respiratory command in newborn mice. Specifically, the central respiratory depression induced by hypoxia is attenuated by acute (1h) or abolished by chronic erythropoietin stimulation. However, the underlying mechanisms remain unknown. As MEK and PI3K pathways are commonly involved in Epo-mediated effects of neuroprotection and erythropoiesis, we investigated here the implication of PI3K and MEK1/2 in the Epo-mediated regulation of t...
Source: Respiratory Physiology and Neurobiology - December 4, 2014 Category: Respiratory Medicine Source Type: research

Effects of tongue position and lung volume on voluntary maximal tongue protrusion force in humans
Publication date: Available online 4 December 2014 Source:Respiratory Physiology & Neurobiology Author(s): Julian P. Saboisky , Billy L. Luu , Jane E. Butler , Simon C. Gandevia Maximal voluntary protrusion force of the human tongue has not been examined in positions beyond the incisors or at different lung volumes. Tongue force was recorded with the tongue tip at eight positions relative to the incisors (12 and 4mm protrusion, neutral and 4, 12, 16, 24 and 32mm retraction) at functional residual capacity (FRC), total lung capacity (TLC) and residual volume (RV) in 15 healthy subjects. Maximal force occurred betw...
Source: Respiratory Physiology and Neurobiology - December 4, 2014 Category: Respiratory Medicine Source Type: research

Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis
Publication date: Available online 4 December 2014 Source:The Lancet Respiratory Medicine Author(s): Peter J Gill , Helen F Ashdown , Kay Wang , Carl Heneghan , Nia W Roberts , Anthony Harnden , Susan Mallett Background Interventions to prevent influenza-related complications are recommended for individuals at the greatest risk of serious clinical deterioration. However, guidelines are based on consensus opinion rather than evidence, and do not specify risk factors in children. We aimed to provide an evidence-based definition of children who are most at risk of such complications. Methods In this systematic review, we s...
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Paediatric influenza vaccination: time to better protect high-risk groups?
Publication date: Available online 4 December 2014 Source:The Lancet Respiratory Medicine Author(s): Harish Nair , Marc-Alain Widdowson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Regular versus as-needed budesonide and formoterol combination treatment for moderate asthma: a non-inferiority, randomised, double-blind clinical trial
This study is registered with ClinicalTrials.gov, number NCT00849095. Findings Between April 20, 2009, and March 31, 2012, we screened 1010 patients with moderate asthma and randomly assigned 866 eligible patients to the two treatment groups (424 to as-needed budesonide and formoterol therapy and 442 to regular budenoside and formoterol therapy). Compared with regular budesonide and formoterol therapy, as-needed budesonide and formoterol treatment was associated with a lower probability of patients having no treatment failure at 1 year (Kaplan-Meier estimates 53·6% for as-needed treatment vs 64·0% for regular treatment;...
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Regular treatment for moderate asthma: guidelines hold true
Publication date: Available online 4 December 2014 Source:The Lancet Respiratory Medicine Author(s): Huib A M Kerstjens , Maarten van den Berge (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Do vaping adverts threaten tobacco control progress in the UK?
Publication date: Available online 3 December 2014 Source:The Lancet Respiratory Medicine Author(s): Tony Kirby (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Predictors of Hospital Length of Stay in Patients with Exacerbations of COPD: A Cohort Study
Conclusions We identified a number of modifiable factors, including baseline dyspnea, physical activity level, and hospital variability, that influenced the LOS of patients with eCOPD who were admitted to the hospital. (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - December 4, 2014 Category: Internal Medicine Source Type: research

Lasso-inspired peptides with distinct antibacterial mechanisms.
Abstract Microcin J25 (MccJ25) is an antibacterial peptide with a peculiar molecular structure consisting of 21 amino acids and a unique lasso topology that makes it highly stable. We synthesized various MccJ25-derived peptides that retained some of the inhibitory activity of the native molecule against Salmonella enterica and Escherichia coli. Of the tested peptides, C1, 7-21C and WK_7-21 were the most inhibitory peptides (MIC = 1-250 µM), but all three were less potent than MccJ25. While MccJ25 was not active against Gram-positive bacteria, the three derived peptides were slightly inhibitory to Gram-positive ...
Source: Amino Acids - December 4, 2014 Category: Biochemistry Authors: Hammami R, Bédard F, Gomaa A, Subirade M, Biron E, Fliss I Tags: Amino Acids Source Type: research

Defining novel health-related quality of life domains in lung transplantation: a qualitative analysis
Conclusions We found that HRQL in lung transplantation is defined by both generic and transplant-specific domains. Delineating and refining these domains can inform efforts to improve clinical outcomes and HRQL measurement in lung transplantation. (Source: Quality of Life Research)
Source: Quality of Life Research - December 4, 2014 Category: Health Management Source Type: research

Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults
Conclusion: Consensus recommendations regarding safety criteria for mobilization of adult, mechanically ventilated patients in ICU have the potential to guide ICU rehabilitation whilst minimizing the risk of adverse events. (Source: Critical Care)
Source: Critical Care - December 4, 2014 Category: Intensive Care Authors: Carol HodgsonKathy StillerDale NeedhamClaire TippingMegan HarroldClaire BaldwinScott BradleySue BerneyLawrence CaruanaDoug ElliottMargot GreenKimberley HainesAlisa HigginsKirsi-Maija KaukonenIsabel LeditschkeMarc NickelsJennifer ParatzShane PatmanElizabet Source Type: research

Cytoplasmic male sterility and mitochondrial metabolism in plants
Publication date: November 2014 Source:Mitochondrion, Volume 19, Part B Author(s): Pascal Touzet , Etienne H. Meyer Cytoplasmic male sterility (CMS) is a common feature encountered in plant species. It is the result of a genomic conflict between the mitochondrial and the nuclear genomes. CMS is caused by mitochondrial encoded factors which can be counteracted by nuclear encoded factors restoring male fertility. Despite extensive work, the molecular mechanism of male sterility still remains unknown. Several studies have suggested the involvement of respiration on the disruption of pollen production through an energy defic...
Source: Mitochondrion - December 4, 2014 Category: Biochemistry Source Type: research

The mitochondrial lysine acetylome of Arabidopsis
Publication date: November 2014 Source:Mitochondrion, Volume 19, Part B Author(s): Ann-Christine König , Markus Hartl , Paul J. Boersema , Matthias Mann , Iris Finkemeier Posttranslational modifications are essential regulators of protein functions as they can modify enzyme activities or protein–molecule interactions by changing the charge state or chemical properties of their target amino acid. The acetyl moiety of the central energy metabolite acetyl-CoA can be transferred to the ε-amino group of lysine, a process known as lysine acetylation which is implicated in the regulation of key metabolic enzymes in various ...
Source: Mitochondrion - December 4, 2014 Category: Biochemistry Source Type: research

Mitochondria and copper homeostasis in plants
Publication date: November 2014 Source:Mitochondrion, Volume 19, Part B Author(s): Lucila Garcia , Elina Welchen , Daniel H. Gonzalez Copper (Cu) and other transition metals are essential for living organisms but also toxic when present in excess. To cope with this apparent paradox, organisms have developed sophisticated mechanisms to acquire, transport and store these metals. Particularly, plant mitochondria require Cu for the assembly and function of cytochrome c oxidase (COX), the terminal enzyme of the respiratory chain. COX assembly is a complex process that requires the action of multiple factors, many of them invo...
Source: Mitochondrion - December 4, 2014 Category: Biochemistry Source Type: research

The life of plant mitochondrial complex I
Publication date: November 2014 Source:Mitochondrion, Volume 19, Part B Author(s): Hans-Peter Braun , Stefan Binder , Axel Brennicke , Holger Eubel , Alisdair R. Fernie , Iris Finkemeier , Jennifer Klodmann , Ann-Christine König , Kristina Kühn , Etienne Meyer , Toshihiro Obata , Markus Schwarzländer , Mizuki Takenaka , Anja Zehrmann The mitochondrial NADH dehydrogenase complex (complex I) of the respiratory chain has several remarkable features in plants: (i) particularly many of its subunits are encoded by the mitochondrial genome, (ii) its mitochondrial transcripts undergo extensive maturation processes (e.g. RNA e...
Source: Mitochondrion - December 4, 2014 Category: Biochemistry Source Type: research

Exploring O2 Diffusion in A-Type Cytochrome c Oxidases: Molecular Dynamics Simulations Uncover Two Alternative Channels towards the Binuclear Site
by A. Sofia F. Oliveira, João M. Damas, António M. Baptista, Cláudio M. Soares Cytochrome c oxidases (Ccoxs) are the terminal enzymes of the respiratory chain in mitochondria and most bacteria. These enzymes couple dioxygen (O2) reduction to the generation of a transmembrane electrochemical proton gradient. Despite decades of research and the availability of a large amount of structural and biochemical data available for the A-type Ccox family, little is known about the channel(s) used by O2 to travel from the solvent/membrane to the heme a3-CuB binuclear center (BNC). Moreover, the identification of all possible O2 ch...
Source: PLoS Computational Biology - December 4, 2014 Category: Biology Authors: A. Sofia F. Oliveira et al. Source Type: research

Re-emerging of Porcine Respiratory and Reproductive Syndrome Virus (Lineage 3) and Increased Pathogenicity after Genomic Recombinationwith Vaccine Variant
This study enhanced our understanding on potential importance of the recombination of PRRSV along with their evolution. (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - December 4, 2014 Category: Veterinary Research Source Type: research

Protective and dysregulated T cell immunity in RSV infection
Publication date: August 2013 Source:Current Opinion in Virology, Volume 3, Issue 4 Author(s): Peter J Openshaw , Christopher Chiu Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicity, production issues and the fear of causing enhanced disease. T cells assist in viral clearance, but immune regulation serves to limit these responses and to prevent the exaggerated inflammatory r...
Source: Current Opinion in Virology - December 4, 2014 Category: Virology Source Type: research

Anxiety disorders and physical comorbidity: increased prevalence but reduced relevance of specific risk factors for hospital-based mortality during a 12.5-year observation period in general hospital admissions
Abstract Anxiety disorders (AD) are associated with an increase in physical comorbidities, but the effects of these diseases on hospital-based mortality are unclear. Consequently, we investigated whether the burden of physical comorbidity and its relevance on hospital-based mortality differed between individuals with and without AD during a 12.5-year observation period in general hospital admissions. During 1 January 2000 and 30 June 2012, 11,481 AD individuals were admitted to seven General Manchester Hospitals. All comorbidities with a prevalence ≥1 % were compared with those of 114,810 randomly selected ...
Source: European Archives of Psychiatry and Clinical Neuroscience - December 4, 2014 Category: Neuroscience Source Type: research

Improving the use of principal component analysis to reduce physiological noise and motion artifacts to increase the sensitivity of task-based fMRI
Conclusions The sensitivity of the optimized CompCor, WCompCor, and LCompCor methods exceeded that of the original CompCor method. However, regressing noise signals showed a paradoxical consequence of reducing specificity for all noise reduction methods attempted. Graphical abstract (Source: Journal of Neuroscience Methods)
Source: Journal of Neuroscience Methods - December 4, 2014 Category: Neuroscience Source Type: research

Central nervous system stimulants: basic pharmacology and relevance to anaesthesia and critical care
Publication date: Available online 28 November 2014 Source:Anaesthesia & Intensive Care Medicine Author(s): Ryan Campbell , Simon P. Young Central nervous system (CNS) stimulants are common in clinical practice, and have a high potential for abuse. The CNS stimulants can be classified as analeptic stimulants, psychomotor stimulants, or methylxanthines. Doxapram activates peripheral chemoreceptors and central respiratory centres in a dose-dependent manner. Psychomotor stimulants (e.g. cocaine and amfetamines) increase sympathetic nervous system activity. Competition for various metabolic and transport processes ca...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Tests of pulmonary function before thoracic surgery
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Andrew N. Davies , Palanikumar Saravanan Respiratory complications contribute significantly to perioperative morbidity and mortality after surgery. There are evidence-based guidelines that support the use of pulmonary function tests (PFTs) and cardiopulmonary exercise testing (CPET) in the preoperative assessment of patients undergoing lung resection surgery to determine whether patients can tolerate the resection. Spirometry, lung volumes and flow–volume analysis provide information on the respiratory m...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Analgesia for thoracic surgery
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Andrew N. Davies , Christopher J. Rozario The pain of thoracic surgery is severe which if addressed correctly reduces morbidity and mortality. Pain arises from muscle dissection, rib retraction and intercostal nerve damage. Management is challenged by pre-existing respiratory and co-morbid disease. Thoracic epidural analgesia for thoracotomy is considered ideal, however paravertebral blockade as part of a multimodal approach increasingly offers a comparable solution. Post-thoracotomy pain syndrome is a sig...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Respiratory system: applied pharmacology
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Richard L. Dodwell , Jonathan B. Kendall Manipulation of respiratory physiology by pharmacological intervention is a significant role of the anaesthetist and intensivist. Successful use of these various agents requires a thorough understanding of their mechanisms of actions, potential side-effects and limitations. These interventions involve changes in airway calibre, secretions and sensitivity of the airway to noxious stimuli. Other agents act to inhibit the depressant effect that sedatives may have on th...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Measurement of gas concentrations (O2, CO2, N2O and volatile agents)
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Shahood Ali , Jason Walker Analysis of respiratory gases is part of standard monitoring, and is used in operating theatres, intensive care units, and for patient transfer. Common methods for oxygen analysis include: galvanic (fuel) cell, Clark (polarographic) electrode, and paramagnetic analyser. Common methods for carbon dioxide measurement include: infrared absorption spectroscopy and Severinghaus electrode. Other methods utilize mass spectroscopy, Raman scattering, and the piezoelectric effect. (Source:...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Fluid balance and non-respiratory functions of the lung
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Emrys Kirkman The primary function of the lung is gas exchange between alveolar gas and the blood flowing through the nearby capillaries. This stage of gas exchange takes place by diffusion. Because gases such as oxygen diffuse relatively slowly through liquids it is essential that the fluid barrier is kept as short as possible. Furthermore, it is vital that interstitial fluid does not escape into the alveoli because this would abolish gas exchange in the flooded alveoli and lead to shunt. A number of phys...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Respiration: control of ventilation
Publication date: November 2014 Source:Anaesthesia & Intensive Care Medicine, Volume 15, Issue 11 Author(s): Emrys Kirkman Rhythmic ventilation is an automatic process controlled by the central nervous system. Groups of cells in the brainstem, predominantly the ventral and dorsal respiratory groups, are responsible for generating basic respiratory rhythm. This basic rhythm is subject to modulation by both conscious and reflex actions. In normal individuals the respiratory minute volume is set to closely regulate arterial carbon dioxide tension (PaCO2) at approximately 5.3 kPa, predominantly via a negative feedbac...
Source: Anaesthesia and intensive care medicine - December 4, 2014 Category: Anesthesiology Source Type: research

Case series discussion of cardiac and vascular events following carfilzomib treatment: possible mechanism, screening, and monitoring
Conclusions: While cardiac and vascular-related adverse events were reported in patients with relapsed and/or refractory multiple myeloma who were treated with carfilzomib, most patients had a history of the specific cardiac or vascular adverse event they exhibited and demonstrated an improvement or resolution in symptoms after the discontinuation of therapy. Appropriate screening and monitoring could potentially allow at-risk patients to benefit fully from treatment with carfilzomib. (Source: BMC Cancer)
Source: BMC Cancer - December 4, 2014 Category: Cancer & Oncology Authors: Ajai ChariDaher Hajje Source Type: research

Rate and patterns of ICU admission among colorectal cancer patients: a single-center experience
Conclusion This is the first study looking at specific causes for unplanned ICU admission of patients with colorectal cancer. Hospital mortality was influenced by the characteristics of the complication that entailed the ICU admission while cancer characteristics retained their prognostic influence on survival after hospital discharge. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - December 4, 2014 Category: Cancer & Oncology Source Type: research

Acute iterative bronchospasm and “do not intubate” orders : sedation by an alpha-2 agonist combined to non-invasive ventilation
A male patient presented with bronchospasm and acute respiratory distress. The patient had presented two previous episodes of severe bronchospasm, following abdominal surgery, leading, twice, to intubation, mechanical ventilation (MV) and conventional sedation. As the patient positively rejected a third episode of intubation+MV, non-invasive ventilation (NIV, pressure support=8cmH20, PEEP=10cmH20), inhaled therapy, and clonidine orally (≈4μg.kg-1) were combined. Over 1–2 hours, the acute respiratory distress disappeared. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 4, 2014 Category: Emergency Medicine Authors: C. Galland, B. Sergent, C. Pichot, M. Ghignone, L. Quintin Tags: Case Reports Source Type: research

Urine lipoarabinomannan point-of-care testing in patients affected by pulmonary nontuberculous mycobacteria ¿ experiences from the Danish Cystic Fibrosis cohort study
Conclusions: This is the first study to assess urine LAM detection in patients with confirmed NTM infection. The study demonstrated low cross-reactivity due to NTM infection when using the recommended grade 2 cut-point as positivity threshold. This is reassuring in regards to interpretation of the LAM test for TB diagnosis in a TB prevalent setting. The test was not found suitable for NTM detection among patients with CF. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - December 4, 2014 Category: Infectious Diseases Authors: Tavs QvistIsik JohansenTania PresslerNiels HøibyAase AndersenTerese KatzensteinStephanie Bjerrum Source Type: research

Total Joint Arthroplasty in Transplant Recipients: In-Hospital Adverse Outcomes
This study aims to determine in-hospital complications and mortality in transplant recipients following TJA. Nationwide Inpatient Sample database was queried for patients with history of transplant and hip or knee arthroplasty (primary or revision) from 1993–2011. Kidney transplant increased risk of surgical site infection (SSI) and wound infections (OR=2.03), systemic infection (OR=2.85), deep venous thrombosis (DVT) (OR=2.07), acute renal failure (ARF) (OR=3.48), respiratory (OR=1.34), and cardiac (OR=1.21) complications. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - December 4, 2014 Category: Orthopaedics Authors: Priscilla K. Cavanaugh, Antonia F. Chen, Mohammad R. Rasouli, Zachary D. Post, Fabio Orozco, Alvin Ong Tags: Original Articles Source Type: research

Activation of c-Src tyrosine kinase mediated the degradation of occludin in ventilator-induced lung injury
Conclusions: Mechanical ventilation can activate c-Src by phosphorylation and increase the degradation of occludin. c-Src inhibitor can ameliorate barrier function and lung injury by up-regulating occludin. (Source: Respiratory Research)
Source: Respiratory Research - December 4, 2014 Category: Respiratory Medicine Authors: Tao ZhaoMengjie LiuChangping GuXin WangYuelan Wang Source Type: research