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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Hepatitis E: A disease of reemerging importance
Publication date: Available online 12 March 2015 Source:Journal of the Formosan Medical Association Author(s): Siddharth Sridhar , Susanna K.P. Lau , Patrick C.Y. Woo Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. Originally considered to be restricted to humans, it is now clear that HEV and HEV-like viruses have several animal reservoirs with complex ecology and genetic diversity, as exemplified by the recent discovery of HEV in dromedaries, a previously underestimated reservoir of zoonotic viruses prior to the emergence of Middle East Respiratory Syndrome coronavirus. Zoonotic food...
Source: Journal of the Formosan Medical Association - March 13, 2015 Category: Journals (General) Source Type: research

Trends in home enteral nutrition at a tertiary teaching hospital: 2005–2013
ConclusionsThe use of home enteral nutrition has increased in the last 9 years at the study hospital. Most patients were registered for oral nutrition support and had an underlying cancer diagnosis, which may have contributed to the high rate of death observed in this patient population. (Source: Nutrition and Dietetics)
Source: Nutrition and Dietetics - March 13, 2015 Category: Nutrition Authors: Elizabeth Kumiko Parker, Sahrish Sonia Faruquie, Peter Talbot Tags: Original Research Source Type: research

Development and Laboratory Evaluation of a Quantitative Real-Time PCR Assay for Detecting Viruses and Bacteria of Relevance for Community-Acquired Pneumonia
Community-acquired pneumonia may present with similar clinical symptoms, regardless of viral or bacterial cause. Diagnostic assays are needed to rapidly discriminate between causes, because this will guide decisions on appropriate treatment. Therefore, a quantitative real-time PCR (qPCR) assay with duplex reactions targeting eight bacteria and six viruses was developed. Technical performance was examined with linear plasmids. Upper and lower respiratory tract specimens were used to compare the qPCR assay with standard microbiological methods. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - March 13, 2015 Category: Pathology Authors: Alicia Edin, Susanne Granholm, Satu Koskiniemi, Annika Allard, Anders Sjöstedt, Anders Johansson Tags: Regular Article Source Type: research

Physical Medicine Interventions as Alternatives to Invasive Airway Tubes
This article describes the use of physical medicine noninvasive inspiratory and expiratory muscle aids to prevent ventilatory/respiratory failure and to permit the extubation and tracheostomy tube decannulation of patients with little or no autonomous ability to breathe (i.e., who are “unweanable” from ventilator support). Noninvasive airway pressure aids can provide up to continuous ventilatory support and effective cough flows for patients with severely dysfunctional respiratory muscles. (Source: PMandR)
Source: PMandR - March 13, 2015 Category: Rehabilitation Source Type: research

Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells
Conclusions These data show that cigarette smoke increases TLR3-stimulated MUC5AC production in airway epithelial cells, mainly via ERK signaling. The effect might be mediated in part by oxidative stress. Modulation of this pathway might be a therapeutic target for viral-induced mucin overproduction in COPD exacerbation. (Source: Respiratory Investigation)
Source: Respiratory Investigation - March 13, 2015 Category: Respiratory Medicine Source Type: research

Phylogenetic analysis of human metapneumovirus detected in hospitalized patients in Kuwait during the years 2009–2011
Human metapneumovirus (hMPV) is an important cause of both upper and lower respiratory tract infections (RTIs) in all age groups. Children, elderly, and immunocompromised individuals are the most affected groups. HMPV infection accounts for 5% of hospitalized patients with respiratory tract infections in Kuwait. It is mostly detected among infants and elderly age groups, and both hMPV genotypes A and B circulate in Kuwait. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - March 13, 2015 Category: Global & Universal Authors: Mariam Al-Turab, Wassim Chehadeh, Widad Al-Nakib Source Type: research

Investigation on cobalt‐oxide nanoparticles cyto‐genotoxicity and inflammatory response in two types of respiratory cells
ABSTRACT The increasing use of cobalt oxide (Co3O4) nanoparticles (NPs) in several applications and the suggested genotoxic potential of Co‐oxide highlight the importance of evaluating Co3O4 NPs toxicity. Cyto‐genotoxic and inflammatory effects induced by Co3O4 NPs were investigated in human alveolar (A549), and bronchial (BEAS‐2B) cells exposed to 1–40 µg ml–1. The physicochemical properties of tested NPs were analysed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Cytotoxicity was studied to analyze cell viability (WST1 test) and membrane damage (LDH assay), direct/oxidative DNA ...
Source: Journal of Applied Toxicology - March 13, 2015 Category: Toxicology Authors: Delia Cavallo, Aureliano Ciervo, Anna Maria Fresegna, Raffaele Maiello, Paola Tassone, Giuliana Buresti, Stefano Casciardi, Sergio Iavicoli, Cinzia Lucia Ursini Tags: Research Article Source Type: research

Conditional O-GlcNAcase Knockout Impacts Metabolism [Metabolism]
O-GlcNAc cycling is maintained by the reciprocal activities of the O-GlcNAc transferase and the O-GlcNAcase (OGA) enzymes. O-GlcNAc transferase is responsible for O-GlcNAc addition to serine and threonine (Ser/Thr) residues and OGA for its removal. Although the Oga gene (MGEA5) is a documented human diabetes susceptibility locus, its role in maintaining insulin-glucose homeostasis is unclear. Here, we report a conditional disruption of the Oga gene in the mouse. The resulting homozygous Oga null (KO) animals lack OGA enzymatic activity and exhibit elevated levels of the O-GlcNAc modification. The Oga KO animals showed near...
Source: Journal of Biological Chemistry - March 13, 2015 Category: Chemistry Authors: Keembiyehetty, C., Love, D. C., Harwood, K. R., Gavrilova, O., Comly, M. E., Hanover, J. A. Tags: Glycobiology and Extracellular Matrices Source Type: research

Structure of Papain-like Protease from IBV [Protein Structure and Folding]
Papain-like protease (PLpro) of coronaviruses (CoVs) carries out proteolytic maturation of non-structural proteins that play a role in replication of the virus and performs deubiquitination of host cell factors to scuttle antiviral responses. Avian infectious bronchitis virus (IBV), the causative agent of bronchitis in chicken that results in huge economic losses every year in the poultry industry globally, encodes a PLpro. The substrate specificities of this PLpro are not clearly understood. Here, we show that IBV PLpro can degrade Lys48- and Lys63-linked polyubiquitin chains to monoubiquitin but not linear polyubiquitin....
Source: Journal of Biological Chemistry - March 13, 2015 Category: Chemistry Authors: Kong, L., Shaw, N., Yan, L., Lou, Z., Rao, Z. Tags: Molecular Biophysics Source Type: research

SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme
Ubiquitin (Ub) and the ubiquitin-like modifier interferon stimulated gene 15 (ISG15) participate in the host defense of viral infections. Viruses, including the Severe Acute Respiratory Syndrome human coronavirus (SARS hCoV), have co-opted Ub/ISG15-conjugation pathways for their own advantage or have evolved effector proteins to counter pro-inflammatory properties of Ub/ISG15-conjugated host proteins. Here, we compare substrate specificities of the papain-like protease (PLpro) from the recently emerged Middle Eastern Respiratory Syndrome (MERS) hCoV to the related protease from SARS, SARS PLpro. Through biochemical assays,...
Source: BJ Structure - March 13, 2015 Category: Biochemistry Authors: M Békés, W Rut, P Kasperkiewicz, M P. C. Mulder, H Ovaa, M Drag, C D Lima, T T Huang Tags: BJ Biomolecules Source Type: research

Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling
We report that conditions resembling congestive heart failure contribute to death during radiation pneumonitis, which indicates new targets for therapy. (Source: Journal of Radiation Research)
Source: Journal of Radiation Research - March 13, 2015 Category: Physics Authors: Medhora, M., Gao, F., Glisch, C., Narayanan, J., Sharma, A., Harmann, L. M., Lawlor, M. W., Snyder, L. A., Fish, B. L., Down, J. D., Moulder, J. E., Strande, J. L., Jacobs, E. R. Tags: Biology Source Type: research

Efficacy of Broadline® spot-on against Aelurostrongylus abstrusus and Troglostrongylus brevior lungworms in naturally infected cats from Italy
Publication date: Available online 12 March 2015 Source:Veterinary Parasitology Author(s): Alessio Giannelli , Emanuele Brianti , Antonio Varcasia , Vito Colella , Claudia Tamponi , Giancarlo Di Paola , Martin Knaus , Lénaïg Halos , Frederic Beugnet , Domenico Otranto The increasing reports of Aelurostrongylus abstrusus infection and the new information on Troglostrongylus brevior have spurred the interest of the scientific community towards the research of pharmaceutical compounds effective against both pathogens. A novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline®, Meri...
Source: Veterinary Parasitology - March 13, 2015 Category: Veterinary Research Source Type: research

Subacute necrotising encephalomyelopathy (Leigh's disease; Leigh syndrome)
Like so many complex and incurable neurological disorders, the disease first described in this journal in 1951 by (Archibald) Denis Leigh (1915–1998; figure 1) as ‘Subacute Necrotising Encephalomyelopathy’ (SNE)1 remained for many years a rare and intriguing enigma, of interest mainly to paediatric neurologists and neuropathologists. The more recent history of this disorder, now designated Leigh syndrome (LS) in view of its heterogeneity, exemplifies the revolution in clinical neurosciences, culminating in the understanding of the consequences of multiple mitochondrial defects through fundamental insights...
Source: Journal of Neurology, Neurosurgery and Psychiatry - March 13, 2015 Category: Neurosurgery Authors: Leigh, P. N., Al-Sarraj, S., DiMauro, S. Tags: Genetics, JNNP Impact commentaries, Brain stem / cerebellum, Neuromuscular disease, Peripheral nerve disease, Ophthalmology, Neuropathology, Child and adolescent psychiatry, Disability, Ear, nose and throat/otolaryngology Source Type: research

Sound‐induced stabilization of breathing and moving
In humans and other animals, the locomotor and respiratory systems are coupled together through mechanical, neurophysiological, and informational interactions. At a macroscopic observer–environment level, these three types of interactions produce locomotor–respiratory coupling (LRC), whose dynamics are evaluated in this paper. A formal analysis of LRC is presented, exploiting tools from synchronization theories and nonlinear dynamics. The results of two recent studies, in which participants were instructed to cycle or exhale at a natural frequency or in synchrony with an external rhythmic sound, are discussed. The metr...
Source: Annals of the New York Academy of Sciences - March 13, 2015 Category: Science Authors: Benoît G. Bardy, Charles P. Hoffmann, Bart Moens, Marc Leman, Simone Dalla Bella Tags: Original Article Source Type: research

Developmental competence of 8?16-cell stage bison embryos produced by interspecies somatic cell nuclear transfer.
This study investigated the developmental potential and mitochondrial function of cattle (Bos taurus), plains bison (Bison bison bison) and wood bison (Bison bison athabascae) embryos produced by iSCNT using domestic cattle oocytes as cytoplasts. Embryos in all groups were analysed for development, accumulation of ATP, apoptosis and gene expression of nuclear- and mitochondrial-encoded genes at the 8-16-cell stage. The results of this study showed no significant differences in the proportion of developed embryos at the 2-, 4- and 8-16-cell stages between groups. However, significantly higher ATP levels were observed in cat...
Source: Reproduction, Fertility, and Development - March 13, 2015 Category: Reproduction Medicine Authors: González-Grajales LA, Favetta LA, King WA, Mastromonaco GF Tags: Reprod Fertil Dev Source Type: research

Recruitment to UK cardiothoracic surgery in the era of public outcome reporting [ADULT CARDIAC]
CONCLUSIONS Repeated negative messages have had a detrimental influence on recruitment. Because 55% of UK medical graduates, but less than 5% of CT surgeons are female, recruitment problems may worsen. Action is needed to restore interest in the specialty. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - March 13, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Westaby, S., Baig, K., De Silva, R., Unsworth-White, J., Pepper, J. Tags: Education, Electrophysiology - arrhythmias, Professional affairs ADULT CARDIAC Source Type: research

Development and Laboratory Evaluation of a Quantitative Real-Time PCR Assay for Detecting Viruses and Bacteria of Relevance for Community-Acquired Pneumonia
Publication date: Available online 13 March 2015 Source:The Journal of Molecular Diagnostics Author(s): Alicia Edin , Susanne Granholm , Satu Koskiniemi , Annika Allard , Anders Sjöstedt , Anders Johansson Community-acquired pneumonia may present with similar clinical symptoms, regardless of viral or bacterial cause. Diagnostic assays are needed to rapidly discriminate between causes, because this will guide decisions on appropriate treatment. Therefore, a quantitative real-time PCR (qPCR) assay with duplex reactions targeting eight bacteria and six viruses was developed. Technical performance was examined with linear p...
Source: The Journal of Molecular Diagnostics - March 13, 2015 Category: Pathology Source Type: research

Carbon Monoxide Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
Abstract Inflammasomes are cytosolic protein complexes that promote the cleavage of caspase-1, which leads to the maturation and secretion of pro-inflammatory cytokines including interleukin-1β(IL-1β) and IL-18. Among the known inflammasomes, the NLRP3-dependent inflammasome is critically involved in the pathogenesis of various acute or chronic inflammatory diseases. Carbon monoxide (CO), a gaseous molecule physiologically produced in cells and tissues during heme catabolism, can act as an anti-inflammatory molecule and a potent negative regulator of Toll-like receptor (TLR) signaling pathways. To date, the role ...
Source: Am J Physiol Lung Ce... - March 13, 2015 Category: Respiratory Medicine Authors: Jung SS, Moon JS, Xu J, Ifedigbo E, Ryter SW, Choi AM, Nakahira K Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Pro-resolving actions of a new Resolvin D1 analog mimetic qualifies as an immunoresolvent.
Abstract Resolution of inflammation is an active process driven by several new families of endogenous lipid mediators collectively coined specialized pro-resolving mediators (SPM). Here, we report a synthetic analog of resolvin D1 (RvD1) and aspirin-triggered RvD1 (AT-RvD1), benzo-diacetylenic-17R-RvD1-methyl ester (BDA-RvD1), which was prepared using fewer steps than required for total organic synthesis of natural SPM. BDA-RvD1 was resistant to further metabolism by human recombinant 15-PGDH, a major inactivation pathway for RvD1. In ischemia-reperfusion initiated second organ injury, BDA-RvD1 (1 μg, i.v.) reduce...
Source: Am J Physiol Lung Ce... - March 13, 2015 Category: Respiratory Medicine Authors: Orr SK, Colas RA, Dalli J, Chiang N, Serhan CN Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Association between early airway damage-associated molecular patterns and subsequent bacterial infection in patients with inhalational and burn injury.
CONCLUSIONS: Independent of initial inhalation injury severity and extent of surface burn, elevated levels of HA dsDNA and IL-10 in the central airways obtained early after injury are associated with subsequent positive bacterial respiratory cultures in patients intubated after acute burn/inhalation injury. PMID: 25770180 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - March 13, 2015 Category: Respiratory Medicine Authors: Maile R, Jones S, Pan Y, Zhou H, Jaspers I, Peden DB, Cairns BA, Noah TL Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Utility of Large-Animal Models of BPD: Chronically Ventilated Preterm Lambs.
Abstract This paper is focused on unique insights provided by the preterm lamb physiological model of bronchopulmonary dysplasia (BPD). Connections are also made to insights provided by the former preterm baboon model of BPD, as well as to rodent models of lung injury to the immature, postnatal lung. The preterm lamb and baboon models recapitulate the clinical setting of preterm birth and respiratory failure that require prolonged ventilation support for days or weeks with oxygen-rich gas. An advantage of the preterm lamb model is the large size of preterm lambs, which facilitates physiologic studies for days or we...
Source: Am J Physiol Lung Ce... - March 13, 2015 Category: Respiratory Medicine Authors: Albertine KH Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Kinetic profiling of in vivo lung cellular inflammatory responses to mechanical ventilation.
This study aimed to identify the profile of in vivo lung cellular activation that occurs during the initiation of VILI. This was achieved using a flow cytometry-based method to quantify the phosphorylation of several markers (p38, ERK1/2, MK2 and NF-κB) of inflammatory pathway activation within individual cell types. Anesthetized C57BL/6 mice were ventilated with low (7ml/kg), intermediate (30ml/kg) or high (40ml/kg) tidal volumes for 1, 5 or 15 minutes followed by immediate fixing and processing of the lungs. Surprisingly, the pulmonary endothelium was the cell type most responsive to in vivo high tidal volume ventilatio...
Source: Am J Physiol Lung Ce... - March 13, 2015 Category: Respiratory Medicine Authors: Woods SJ, Waite AA, O'Dea KP, Halford P, Takata M, Wilson MR Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Whole left ventricular functional assessment from two minutes free breathing multi-slice CINE acquisition.
Abstract Two major challenges in cardiovascular MRI are long scan times due to slow MR acquisition and motion artefacts due to respiratory motion. Recently, a Motion Corrected-Compressed Sensing (MC-CS) technique has been proposed for free breathing 2D dynamic cardiac MRI that addresses these challenges by simultaneously accelerating MR acquisition and correcting for any arbitrary motion in a compressed sensing reconstruction. In this work, the MC-CS framework is combined with parallel imaging for further acceleration, and is termed Motion Corrected Sparse SENSE (MC-SS). Validation of the MC-SS framework is demonst...
Source: Physics in Medicine and Biology - March 13, 2015 Category: Physics Authors: Usman M, Atkinson D, Heathfield E, Greil G, Schaeffter T, Prieto C Tags: Phys Med Biol Source Type: research

Update of the results of the Spanish branch of the European randomized study on screening for prostate cancer (ERSPC).
CONCLUSIONS: PC screening results in a shifting of the diagnosis towards earlier stages. Nevertheless, we have not demonstrated a benefit in terms of overall or cancer-specific survival after more than 15 years of follow-up. The low mortality from this disease in our community could be one of the main factors that explain these results. PMID: 25777669 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - March 13, 2015 Category: Urology & Nephrology Authors: Luján M, Páez Á, Angulo JC, Andrés G, Gimbernat H, Redondo C, Torres GM, Berenguer A Tags: Actas Urol Esp Source Type: research

Pathogenesis of novel reassortant avian influenza virus A (H5N8) Isolates in the ferret.
Abstract Outbreaks of avian influenza virus H5N8 first occurred in 2014, and spread to poultry farms in Korea. Although there was no report of human infection by this subtype, it has the potential to threaten human public health. Therefore, we evaluated the pathogenesis of H5N8 viruses in ferrets. Two representative Korean H5N8 strains did not induce mortality and significant respiratory signs after an intranasal challenge in ferrets. However, ferrets intratracheally infected with A/broiler duck/Korea/Buan2/2014 virus showed dose-dependent mortality. Although the Korean H5N8 strains were classified as the HPAI viru...
Source: Virology - March 13, 2015 Category: Virology Authors: Kim HM, Kim CK, Lee NJ, Chu H, Kang C, Kim K, Lee JY Tags: Virology Source Type: research

Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease.
Abstract Cowpox virus (CPXV) inoculation of nonhuman primates (NHPs) has been suggested as an alternate model for smallpox (Kramski et al., 2010, PLoS One, 5, e10412). Previously, we have demonstrated that intrabronchial inoculation of CPXV-Brighton Red (CPXV-BR) into cynomolgus monkeys resulted in a disease that shared many similarities to smallpox; however, severe respiratory tract disease was observed (Smith et al., 2011, J. Gen. Virol.). Here we describe the course of disease after small particle aerosol exposure of rhesus monkeys using computed tomography (CT) to monitor respiratory disease progression. Subjec...
Source: Virology - March 13, 2015 Category: Virology Authors: Johnson RF, Hammoud DA, Lackemeyer MG, Yellayi S, Solomon J, Bohannon JK, Janosko KB, Jett C, Cooper K, Blaney JE, Jahrling PB Tags: Virology Source Type: research

Erratum: Allergic diseases and asthma in the family predict the persistence and onset-age of asthma: a prospective cohort study
No description available (Source: Respiratory Research)
Source: Respiratory Research - March 13, 2015 Category: Respiratory Medicine Authors: Elina PaasoMaritta JaakkolaAino RantalaTimo HuggJouni Jaakkola Source Type: research

Resolution of alcohol-induced respiratory symptoms following aspirin desensitization in aspirin-exacerbated respiratory disease.
PMID: 25778863 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2015 Category: Allergy & Immunology Authors: Calais CJ, Banks TA Tags: Ann Allergy Asthma Immunol Source Type: research

Association of P2RY12 polymorphisms with eosinophil and platelet activation in patients with aspirin-exacerbated respiratory disease.
PMID: 25778862 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 13, 2015 Category: Allergy & Immunology Authors: Losol P, Palikhe NS, Lee JW, Palikhe S, Kim MA, Yang EM, Choi H, Choi GS, Kim SH, Park HS Tags: Ann Allergy Asthma Immunol Source Type: research

Macrophage uptake of cylindrical microparticles investigated with correlative microscopy.
Abstract Cylindrical particles offer the opportunity to develop controlled and sustained release systems for the respiratory tract. One reason is that macrophages can phagocyte such particles only from either of the two ends. We investigated the uptake behavior of murine alveolar macrophages incubated with elongated submicron-structured particles. For that purpose, fluorescent model silica nanoparticles were interconnected with the biocompatible polysaccharide agarose, building up cylindrical particles within the pores of track-etched membranes. In contrast to common approaches we determined the uptake at different...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 13, 2015 Category: Drugs & Pharmacology Authors: Tscheka C, Hittinger M, Lehr CM, Schneider-Daum N, Schneider M Tags: Eur J Pharm Biopharm Source Type: research

Why Not Use a Surfactant Test for Respiratory Distress Syndrome?
PMID: 25790960 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - March 13, 2015 Category: Perinatology & Neonatology Authors: Fiori HH, Fiori RM Tags: Neonatology Source Type: research

A National Point-Prevalence Survey of Pediatric Intensive Care Unit-Acquired, Healthcare-Associated Infections in Turkey.
The objective of this point prevalence study was to assess the burden of HCAIs in the PICUs. The study conducted in 50 PICUs across Turkey. Data on demographics, microbiological findings, and therapeutic interventions and outcomes were collected for all PICU inpatients. A total of 327 patients participated in the study, 122 of whom had one or more HCAI, corresponding to a prevalence of 37%. The most frequently reported site was lower respiratory tract (n=77, 63%). The most frequent pathogens were Pseudomonas aeruginosa, Acinetobacter spp. and Candida spp. Two hundred and forty-seven patients (75%) were receiving antimicrob...
Source: Japanese Journal of Infectious Diseases - March 13, 2015 Category: Infectious Diseases Authors: Kepenekli E, Soysal A, Yalindag-Ozturk N, Ozgur O, Ozcan I, Devrim I, Akar S, Bakir M, Turkish PICU-HCAI Study Group Tags: Jpn J Infect Dis Source Type: research

Development and Laboratory Evaluation of a Real-Time PCR Assay for Detecting Viruses and Bacteria of Relevance for Community-Acquired Pneumonia
Community-acquired pneumonia may present with similar clinical symptoms, regardless of viral or bacterial cause. Diagnostic assays are needed to rapidly discriminate between causes, because this will guide decisions on appropriate treatment. Therefore, a quantitative real-time PCR (qPCR) assay with duplex reactions targeting eight bacteria and six viruses was developed. Technical performance was examined with linear plasmids. Upper and lower respiratory tract specimens were used to compare the qPCR assay with standard microbiological methods. (Source: Journal of Molecular Diagnostics)
Source: Journal of Molecular Diagnostics - March 13, 2015 Category: Pathology Authors: Alicia Edin, Susanne Granholm, Satu Koskiniemi, Annika Allard, Anders Sjöstedt, Anders Johansson Tags: Regular Article Source Type: research

Early Decline in Six-Minute Walk Distance from the Time of Diagnosis Predicts Clinical Worsening in Pulmonary Arterial Hypertension
Conclusions: Early declines in 6MWD (within the first 6 months) predict future clinical worsening of PAH with high specificity. #x0394;6MWD may still be part of a comprehensive assessment of a patient's clinical status. However, given the poor sensitivity, a decline in 6MWD should be used with other clinical tools to make an appropriate assessment of the progression of PAH.Respiration (Source: Respiration)
Source: Respiration - March 12, 2015 Category: Respiratory Medicine Source Type: research

Incidence of Respiratory Viral Infections Detected by PCR and Real-Time PCR in Adult Patients with Community-Acquired Pneumonia: A Meta-Analysis
Conclusions: Respiratory viruses are probably crucial pathogens of adult patients with CAP, with the influenza virus being the most frequent viral pathogen identified. More than half of the viral infections are characterized as mixed infections with other pathogens.Respiration (Source: Respiration)
Source: Respiration - March 12, 2015 Category: Respiratory Medicine Source Type: research

Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients.
CONCLUSIONS: Der f 2 was the most frequently sensitized allergen among the HDM-sensitized respiratory and AD patients in Korea, and the combination of the group 1 and 2 major allergens increased the diagnostic sensitivity. Minor allergens did not significantly improve diagnostic sensitivity. However, further studies are needed to analyze the relationship between sensitization to other HDM allergens and the disease entity of the HDM allergy. PMID: 25749773 [PubMed - as supplied by publisher] (Source: Allergy, Asthma and Immunology Research)
Source: Allergy, Asthma and Immunology Research - March 12, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

Hypersensitivity Pneumonitis Caused by Cephalosporins With Identical R1 Side Chains.
We describe a 54-year-old man with hypersensitivity pneumonitis caused by cephalosporins with identical R1 side chains. The patient, who complained of cough with sputum, was prescribed ceftriaxone and clarithromycin at a local clinic. The following day, he complained of dyspnea, and chest X-ray revealed worsening of inflammation. Upon admission to our hospital, antibiotics were changed to cefepime with levofloxacin, but his pneumonia appeared to progress. Changing antibiotics to meropenem with ciprofloxacin improved his symptoms and radiologic findings. Antibiotics were de-escalated to ceftazidime with levofloxacin, and hi...
Source: Allergy, Asthma and Immunology Research - March 12, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

OP-145 A Rare Cause of Ortner's Syndrome: Giant Pulmonary Artery Aneurysm Secondary to Behçet's Disease
Behçet' s disease is a multiorgan disorder of unknown origin and can cause complications in cardiovascular system, central nervous system and respiratory system resulting from vasculitis of both arteries and veins. Vocal cord paralysis due to extralaryngeal cardiovascular pathologies, such as the thoracic aorta aneurysms and pulmonary artery aneurysm is defined as Ortner syndrome. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - March 12, 2015 Category: Cardiology Authors: Abdullah Çelik, Ahmet Karagöz, Erdal Seren, Sefer Usta, Aslı Vural, Bengi Başer Tags: Oral Abstract Source Type: research

Respiratory dysfunction in Charcot–Marie–Tooth disease type 1A
Abstract We aimed to investigate the relationship between neurological compromise, respiratory parameters in wakefulness and in sleep, physiology, and morphology of phrenic nerves in patients with Charcot–Marie–Tooth disease type 1A (CMT1A). Sixteen patients with CMT1A were evaluated by spirometry, maximal expiratory and maximal inspiratory pressures (MEP, MIP), polysomnography, phrenic nerve compound muscle action potential (CMAP), and ultrasonography (roots C3,C4,C5 and phrenic nerves). Clinical disability was measured with Charcot–Marie–Tooth neuropathy score (CMT-NS; range 0–36). Two control grou...
Source: Journal of Neurology - March 12, 2015 Category: Neurology Source Type: research

Pulmonary Biodistribution and Cellular Uptake of Intranasally Administered Monodisperse Particles
Conclusions The findings reported herein indicate that both size and chemistry control the fate of intranasally administered particles and that the dynamics of particle association with phagocytic cells in the lungs provide important insights for the rational design of pulmonary vaccine delivery vehicles. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - March 12, 2015 Category: Drugs & Pharmacology Source Type: research

Physiological Performance Determinants of a 22 km Handbiking Time Trial.
CONCLUSIONS: VO2peak, POpeak, ventilatory thresholds, %VO2peak and C appeared to be important physiological performance determinants of HB time trial. PMID: 25756541 [PubMed - as supplied by publisher] (Source: International Journal of Sports Physiology and Performance)
Source: International Journal of Sports Physiology and Performance - March 12, 2015 Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research

Vector-mediated antibody gene transfer for infectious diseases.
Authors: Schnepp BC, Johnson PR Abstract This chapter discusses the emerging field of vector-mediated antibody gene transfer as an alternative vaccine for infectious disease, with a specific focus on HIV. However, this methodology need not be confined to HIV-1; the general strategy of vector-mediated antibody gene transfer can be applied to other difficult vaccine targets like hepatitis C virus, malaria, respiratory syncytial virus, and tuberculosis. This approach is an improvement over classical passive immunization strategies that administer antibody proteins to the host to provide protection from infection. With...
Source: Advances in Experimental Medicine and Biology - March 12, 2015 Category: Research Tags: Adv Exp Med Biol Source Type: research

Data-driven respiratory motion tracking and compensation in CZT cameras: A comprehensive analysis of phantom and human images
Conclusion The described method allows for tracking and compensating respiratory motion in CZT cameras. Significant respiratory motion is still not uncommon using CZT cameras, especially in patients who underwent treadmill tests. Motion blurring can be compensated using image processing techniques and image quality could be significantly improved. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - March 12, 2015 Category: Nuclear Medicine Source Type: research

Accuracy of a questionnaire for identifying respiratory allergies in epidemiological studies.
CONCLUSION: The questionnaire significantly distinguished subjects with respiratory allergy from those without. The QIRA represents a valid and accurate tool for classifying subjects as having or not AA and/or AR in epidemiological studies. PMID: 25756078 [PubMed - in process] (Source: Rhinology)
Source: Rhinology - March 12, 2015 Category: ENT & OMF Tags: Rhinology Source Type: research

Update on Noninfectious Inflammatory Diseases of the Lower Airway
Inflammatory airway disease and recurrent airway obstruction are 2 nonseptic diseases of the equine respiratory system with a shared cause of exposure to particulate matter. They appear to occupy 2 ends of a spectrum of disease, but are differentiated by history, clinical signs, and response to treatment. Diagnosis can be made by sampling of respiratory fluids and lung function testing. Treatment consists of environmental modification and pharmacologic treatment with systemic or inhaled corticosteroids and bronchodilators. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - March 12, 2015 Category: Veterinary Research Authors: Melissa R. Mazan Source Type: research