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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms.
Authors: Engelhardt KR, Grimbacher B Abstract Inflammatory bowel disease (IBD) represents a heterogeneous group of gastrointestinal disorders, where commensal gut flora provokes an either (a) insufficient or (b) uncontrolled immune response. This results either in a lack of or in excessive inflammation mainly manifesting as Crohn's disease or ulcerative colitis. IBD commonly presents in adolescence and adulthood and often follows a chronic relapsing course. Genetic and/or environmental factors contribute to the failure of gut immune homeostasis. Genome-wide association studies have identified over 160 susceptibilit...
Source: Current Topics in Microbiology and Immunology - November 12, 2014 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research

Mammalian models for the study of h7 virus pathogenesis and transmission.
Authors: Belser JA, Tumpey TM Abstract Mammalian models, most notably the mouse and ferret, have been instrumental in the assessment of avian influenza virus pathogenicity and transmissibility, and have been used widely to characterize the molecular determinants that confer H5N1 virulence in mammals. However, while H7 influenza viruses have typically been associated with conjunctivitis and/or mild respiratory disease in humans, severe disease and death is also possible, as underscored by the recent emergence of H7N9 viruses in China. Despite the public health need to understand the pandemic potential of this virus ...
Source: Current Topics in Microbiology and Immunology - November 12, 2014 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research

Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule.
Authors: Oldstone MB, Rosen H Abstract Cytokine storm defines a dysregulation of and an excessively exaggerated immune response most often accompanying selected viral infections and several autoimmune diseases. Newly emerging and re-emerging infections of the respiratory tract, especially influenza, SARS, and hantavirus post considerable medical problems. Their morbidities and mortalities are often a direct result of cytokine storm. This chapter visits primarily influenza virus infection and resultant cytokine storm. It provides the compelling evidence that illuminates cytokine storm in influenza pathogenesis and t...
Source: Current Topics in Microbiology and Immunology - November 12, 2014 Category: Microbiology Tags: Curr Top Microbiol Immunol Source Type: research

Serendipitous diagnosis of cor triatriatum sinister in a child with Kawasaki disease
We report the case of a boy who was incidentally diagnosed with cor triatriatum by echocardiography during diagnosis and treatment of Kawasaki disease. He has had no definite life-threatening symptoms except recurring respiratory infections. Serial follow-up of such patients is mandatory to check for the potential risks related to the anomalous inter-atrial structure. <Learning objective: Cor triatriatum is a rare congenital heart disease. We report a child who was incidentally diagnosed with cor triatriatum during diagnosis and treatment of Kawasaki disease. This child's cor triatriatum was not related to Kawasaki ...
Source: Journal of Cardiology Cases - November 12, 2014 Category: Cardiology Source Type: research

The pattern of infection and antibiotics use in terminal cancer patients
Conclusions Our study revealed that antibiotic therapy for terminal cancer patients should be on a clear rationale. We need further study to clarify if there is survival effect with antibiotic use or not. (Source: Journal of the Egyptian National Cancer Institute)
Source: Journal of the Egyptian National Cancer Institute - November 12, 2014 Category: Cancer & Oncology Source Type: research

The human papillomavirus family and its role in carcinogenesis
Publication date: June 2014 Source:Seminars in Cancer Biology, Volume 26 Author(s): Massimo Tommasino Human papillomaviruses (HPVs) are a family of small double-stranded DNA viruses that have a tropism for the epithelia of the genital and upper respiratory tracts and for the skin. Approximately 150 HPV types have been discovered so far, which are classified into several genera based on their DNA sequence. Approximately 15 high-risk mucosal HPV types are clearly associated with cervical cancer; HPV16 and HPV18 are the most carcinogenic since they are responsible for approximately 50% and 20% of all cervical cancers worldw...
Source: Seminars in Cancer Biology - November 12, 2014 Category: Cancer & Oncology Source Type: research

Oral pathogens in children with respiratory disease
Discussion We noted that the bacterial load of specific bacteria in the palate increased with Hellman dental age. Furthermore, the increase in bacterial load in the oral cavity at stage IA, when teeth have not yet erupted, suggests the need for oral management. (Source: Pediatric Dental Journal)
Source: Pediatric Dental Journal - November 12, 2014 Category: Dentistry Source Type: research

Septic thrombosis of the internal jugular vein: Lemierre's syndrome revisited
ConclusionIn the pre‐antibiotic time, septic internal jugular vein thrombophlebitis was a highly fatal condition with a mortality rate of 90%. Modern imaging techniques allow early and often incidental diagnosis of this clinically hidden complication. Anticoagulation, intensive antibiotic therapy assisted by surgery of the primary infection site, and intensive supportive care can reach remission rates of 100%. Level of Evidence3b. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - November 12, 2014 Category: ENT & OMF Authors: Adrian D. Schubert, Michel‐André Hotz, Marco D. Caversaccio, Andreas Arnold Tags: Head and Neck Source Type: research

Incidence and risk factors for early neonatal mortality in newborns with severe perinatal morbidity in Uganda
Conclusion Approximately one in 10 neonates with severe perinatal morbidity died within 7days of birth. Respiratory distress and poor monitoring of labor were risk factors for early neonatal death. (Source: International Journal of Gynecology and Obstetrics)
Source: International Journal of Gynecology and Obstetrics - November 12, 2014 Category: OBGYN Source Type: research

p63+Krt5+ distal airway stem cells are essential for lung regeneration
Nature advance online publication 12 November 2014. doi:10.1038/nature13903 Authors: Wei Zuo, Ting Zhang, Daniel Zheng'An Wu, Shou Ping Guan, Audrey-Ann Liew, Yusuke Yamamoto, Xia Wang, Siew Joo Lim, Matthew Vincent, Mark Lessard, Christopher P. Crum, Wa Xian & Frank McKeon Lung diseases such as chronic obstructive pulmonary disease and pulmonary fibrosis involve the progressive and inexorable destruction of oxygen exchange surfaces and airways, and have emerged as a leading cause of death worldwide. Mitigating therapies, aside from impractical organ transplantation, remain limited and the possibility of regenerative ...
Source: Nature AOP - November 12, 2014 Category: Research Authors: Wei ZuoTing ZhangDaniel Zheng'An WuShou Ping GuanAudrey-Ann LiewYusuke YamamotoXia WangSiew Joo LimMatthew VincentMark LessardChristopher P. CrumWa XianFrank McKeon Tags: Letter Source Type: research

Polymorphism of LRP5 gene and emphysema severity are associated with osteoporosis in Japanese patients with or at risk for COPD
ConclusionsThis study confirmed the complex pathophysiology of COPD‐related osteoporosis, including the influence of gender, clinical phenotype and genetic factors. (Source: Respirology)
Source: Respirology - November 12, 2014 Category: Respiratory Medicine Authors: Shotaro Chubachi, Hidetoshi Nakamura, Mamoru Sasaki, Mizuha Haraguchi, Masaki Miyazaki, Saeko Takahashi, Kyuto Tanaka, Yohei Funatsu, Koichiro Asano, Tomoko Betsuyaku, Tags: Original Article Source Type: research

Endotracheal tube securements: Effectiveness of three techniques among orally intubated patients
Conclusion It is concluded that Twill technique is an ETT securement technique in ICUs for orally intubated patients. Recommendations It is recommended to use this method, with development of strategies to prevent slippage aiming at increasing patient safety after securement technique intervention. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - November 12, 2014 Category: Respiratory Medicine Source Type: research

Inflammation-induced atrial fibrillation: Pathophysiological perspectives and clinical implications
Publication date: Available online 12 November 2014 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Salah S. Al-Zaiti Although atrial fibrillation (AF) is the most common type of cardiac arrhythmia, its etiology is unknown in nearly 10% of cases. Growing evidence suggests that inflammation plays a significant role in the onset and recurrence of AF. The role of inflammation in the pathogenesis of AF has important clinical implications of which many practitioners are unfamiliar. In this article, we describe a case of a 29-year-old male, who presents the emergency department with inflammation-...
Source: Heart and Lung: The Journal of Acute and Critical Care - November 12, 2014 Category: Respiratory Medicine Source Type: research

Airway smooth muscle in asthma: Linking contraction and mechanotransduction to disease pathogenesis and remodelling
Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): Peter B. Noble , Chris D. Pascoe , Bo Lan , Satoru Ito , Loes E.M. Kistemaker , Amanda L. Tatler , Tonio Pera , Bindi S. Brook , Reinoud Gosens , Adrian R. West Asthma is an obstructive airway disease, with a heterogeneous and multifactorial pathogenesis. Although generally considered to be a disease principally driven by chronic inflammation, it is becoming increasingly recognised that the immune component of the pathology poorly correlates with the clinical symptoms of asthma, thus highlighting a potentia...
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Ca2+ handling and sensitivity in airway smooth muscle: Emerging concepts for mechanistic understanding and therapeutic targeting
Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): T. Koopmans , V. Anaparti , I. Castro-Piedras , P. Yarova , N. Irechukwu , C. Nelson , J. Perez-Zoghbi , X. Tan , J.P.T. Ward , D.B. Wright Free calcium ions within the cytosol serve as a key secondary messenger system for a diverse range of cellular processes. Dysregulation of cytosolic Ca2+ handling in airway smooth muscle (ASM) has been implicated in asthma, and it has been hypothesised that this leads, at least in part, to associated changes in both the architecture and function of the lung. Significant...
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Pathological changes in the COPD lung mesenchyme – Novel lessons learned from in vitro and in vivo studies
Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): Oluwaseun Ojo , Anna L. Lagan , Vijayanand Rajendran , Anita Spanjer , Ling Chen , Sukhwinder Singh Sohal , Irene Heijink , Robin Jones , Harm Maarsingh , Tillie L. Hackett Chronic obstructive pulmonary disease (COPD) is currently the fourth leading cause of death worldwide and, in contrast to the trend for cardiovascular diseases, mortality rates still continue to climb. This increase is in part due to an aging population, being expanded by the “Baby boomer” generation who grew up when smoking rates we...
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Regulation of pulmonary inflammation by mesenchymal cells
Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): Hatem Alkhouri , Wilfred Jelco Poppinga , Navessa Padma Tania , Alaina Ammit , Michael Schuliga Pulmonary inflammation and tissue remodelling are common elements of chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary hypertension (PH). In disease, pulmonary mesenchymal cells not only contribute to tissue remodelling, but also have an important role in pulmonary inflammation. This review will describe the immunomodulato...
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo models
Publication date: December 2014 Source:Pulmonary Pharmacology & Therapeutics, Volume 29, Issue 2 Author(s): Katie E. Baker , Sara J. Bonvini , Chantal Donovan , Rachel E. Foong , Bing Han , Aruni Jha , Yasin Shaifta , Marieke Smit , Jill R. Johnson , Lyn M. Moir Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent respiratory diseases characterized by airway inflammation, airway obstruction and airway hyperresponsiveness. Whilst current therapies, such as β-agonists and glucocorticoids, may be effective at reducing symptoms, they do not reduce disease progression. Thus, there is a need to...
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Thrombomodulin for acute exacerbations of idiopathic pulmonary fibrosis: A proof of concept study
Conclusion AE-IPF-patients were found to have significantly higher levels of coagulation. The rhTM administration in the surviving AE-IPF-patients led to significant differences in the oxygenation and intravascular coagulation disturbance. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Pathogen characteristics reveal novel antibacterial approaches for interstitial lung disease
In conclusion, aminoglycosides and carbapenems may be selected as a priority for secondary infection to control ILD progression. Meanwhile, the use of anti-MRSA/MRCNS drugs may be considered for Staphylococcus infection. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - November 12, 2014 Category: Respiratory Medicine Source Type: research

Universal access to pneumonia prevention and care: a call for action
Publication date: Available online 12 November 2014 Source:The Lancet Respiratory Medicine Author(s): Karin Källander , Mark Young , Shamim Qazi (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 12, 2014 Category: Respiratory Medicine Source Type: research

Approaches to achieving equality in respiratory health
Publication date: Available online 12 November 2014 Source:The Lancet Respiratory Medicine Author(s): Patricia W Finn , Rubin Cohen (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 12, 2014 Category: Respiratory Medicine Source Type: research

Emergency Thyroidectomy: Due to Acute Respiratory Failure
Conclusion Respiratory failure due to giant nodular goiter is a life threatening situation and treatment requirements primarily endotracheal intubation. Awake endotracheal intubation is an appropriate approach in these cases. Emergency total thyroidectomy is recommended following intubation. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - November 12, 2014 Category: Surgery Source Type: research

Congenital superior sternal cleft repair using our modified Sally technique: a case report
We report the case of an 8-month-old male neonate who underwent reconstructive surgery for a congenital superior sternal cleft to decrease the risk of commotio cordis. With regard to use of the Sally technique for the repair of a relatively wide cleft(4×4 cm), we were concerned about respiratory problems caused by compression following closure of the sternal halves. By closing the sternal halves imperfectly, elevation of intrapleural pressure can be avoided to some extent. By bridging the surplus resected cartilage from the lower sternum over the gap of the upper sternum, the heart is protected by more rigid material. We ...
Source: Journal of Pediatric Surgery Case Reports - November 12, 2014 Category: Surgery Source Type: research

Respiratory sinus arrhythmia in young men and women at different chest wall configurations
Respiratory sinus arrhythmia (RSA) is an acceleration of heart rate during inspiration and deceleration with expiration. We asked whether or not in humans some of the volume-related information necessary for RSA originated from the chest wall. Men and women, 19-20 years old, were breathing supine. Rib cage and abdomen displacement provided an index of tidal volume (VT) and RSA was computed breath-by-breath from the peak and trough of instantaneous heart rate. First, measurements were taken during breathing at rest (protocol a, 129 ♂ and 164 ♀). Then, in subgroups of the original subject population, measuremen...
Source: Clinical Science - November 12, 2014 Category: Biomedical Science Authors: J P. Mortola, D Marghescu, R Siegrist-Johnstone Source Type: research

Detection of Human Bocavirus in Children with Acute Respiratory Tract Infections in Lanzhou and Nanjing, China
Conclusions Presence of HBoV1 in nasopharyngeal aspirates did not correlate with region or gender, although the prevalence of HBoV1 was higher in younger children. There were no correlations between HBoV1 and other variables, except for the season and ADV, RSV, or IFVA infections. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 12, 2014 Category: Biomedical Science Source Type: research

Molecular Bases and Role of Viruses in the Human Microbiome
Publication date: 25 November 2014 Source:Journal of Molecular Biology, Volume 426, Issue 23 Author(s): Shira R. Abeles , David T. Pride Viruses are dependent biological entities that interact with the genetic material of most cells on the planet, including the trillions within the human microbiome. Their tremendous diversity renders analysis of human viral communities (“viromes”) to be highly complex. Because many of the viruses in humans are bacteriophage, their dynamic interactions with their cellular hosts add greatly to the complexities observed in examining human microbial ecosystems. We are only beginning to b...
Source: Journal of Molecular Biology - November 12, 2014 Category: Molecular Biology Source Type: research

Risk factors of mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia
Conclusions Risks of mortality for CRAB included ICU stay, high APACEH II score, respiratory tract as the origin of bacteremia and previous use of ceftriaxone. Early implementation of antimicrobial that had the highest in vitro activity against CRAB in patients at risk of CRAB bacteremia and high mortality might improve their outcome. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 12, 2014 Category: Microbiology Source Type: research

Defective innate immune responses to respiratory syncytial virus infection in ovalbumin-sensitized mice
Conclusion The defective anti-viral innate response was observed in murine respiratory allergy model. Suppressed expression of IFN signal transcriptor contribute to decreased production of type I IFN. The defective innate immune response might result to the acute viral exacerbations of allergic airway diseases. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - November 12, 2014 Category: Microbiology Source Type: research

Multilocus Sequence Typing of Mycoplasma bovis Reveals Host-Specific Genotypes in Cattle versus Bison
This study describes the development of a highly discriminatory multilocus sequencing typing (MLST) method for M. bovis and its use to investigate the population structure of the bacterium. Genome sequences from six M. bovis isolates were used for selection of gene targets. Seven of 44 housekeeping genes initially evaluated were selected as targets on the basis of sequence variability and distribution within the genome. For each gene target sequence, four to seven alleles could be distinguished that collectively define 32 sequence types (STs) from a collection of 94 cattle isolates and 42 bison isolates. A phylogeny based ...
Source: Veterinary Microbiology - November 12, 2014 Category: Veterinary Research Source Type: research

Relation between Aelurostrongylus abstrusus larvae excretion, respiratory and radiographic signs in naturally infected cats
Publication date: Available online 3 November 2014 Source:Veterinary Parasitology Author(s): Marco Genchi , Nicola Ferrari , Paolo Fonti , Ivana De Francesco , Carlotta Piazza , Antonio Viglietti A study was carried out to assess the possible relation between the number of Aelurostrongylus abstrusus larvae per gram of feces (LPG) with respiratory signs and radiographic findings in naturally infected cats. Out of 196 owned cats, 52 (26.5%) were found infected with A. abstrusus. Positive cats were divided into 4 age groups (1, 2–6 months; 2, 7–11 months; 3, 1–5 years and, 4, >6 years). Thoracic radiographs in ...
Source: Veterinary Parasitology - November 12, 2014 Category: Veterinary Research Source Type: research

Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine
Dyspnea, ‘hunger for air’, and the urge to flee are the cardinal symptoms of respiratory-type panic attacks. Patients also show baseline respiratory abnormalities and a higher rate of comorbid and antecedent respiratory diseases. Panic attacks are also precipitated by both the infusion of 0.5 M sodium lactate and the inhalation of 5–7% carbon dioxide (CO2) in predisposed patients, but not in healthy volunteers nor patients without panic disorder. Further studies show that patients with panic are also hyper-responsive to hypoxia. These and other observations led Klein (1993) to suggest that clinical panic ...
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Schimitel, F. G., Muller, C. J. T., Tufik, S., Schenberg, L. C. Tags: Short Reports Source Type: research

Step-by-step clinical management of one-lung ventilation: Continuing Professional Development
Conclusions Optimal perioperative care of the thoracic patient includes a protective ventilation strategy from intubation to extubation and into the immediate postoperative period. Anesthetic goals include the prevention of perioperative hypoxemia and postoperative ALI. (Source: Canadian Journal of Anesthesia)
Source: Canadian Journal of Anesthesia - November 12, 2014 Category: Anesthesiology Source Type: research

Potential respiratory pathogens colonisation of the denture plaque of patients with chronic obstructive pulmonary disease
ConclusionsDenture plaque could be a potential source of bacterial and fungal infections in patients with COPD. (Source: Gerodontology)
Source: Gerodontology - November 12, 2014 Category: Dentistry Authors: Dorota Przybyłowska, Elżbieta Mierzwińska‐Nastalska, Ewa Swoboda‐Kopeć, Renata Rubinsztajn, Ryszarda Chazan Tags: Original Article Source Type: research

Late-onset volvulus without malrotation in extremely preterm infants - a case¿control-study
Conclusions: In extremely premature infants volvulus without malrotation represents a life-threatening event that occurs typically several weeks after birth with an acute abdomen and seems to affect predominantly girls. Infants requiring intensive non-invasive respiratory support might be at highest risk. (Source: BMC Pediatrics)
Source: BMC Pediatrics - November 12, 2014 Category: Pediatrics Authors: Christoph MaasStefanie HammerHans-Joachim KirschnerYasemin YarkinChristian PoetsAxel Franz Source Type: research

Asthma incidence, remission, relapse and persistence: a population-based study in southern Taiwan
Conclusions: In Asian population, asthma occurrence showed a U-shape age distribution with a prominent second peak in the thirties. A high proportion of early-onset asthma relapsed and most of late-onset asthma persisted or relapsed in adulthood. (Source: Respiratory Research)
Source: Respiratory Research - November 12, 2014 Category: Respiratory Medicine Authors: Tsung-Ju WuChang-Fu WuYungling LeeTzuen-Ren HsiueYue Guo Source Type: research

Step-by-step clinical management of one-lung ventilation: Continuing Professional Development.
CONCLUSIONS: Optimal perioperative care of the thoracic patient includes a protective ventilation strategy from intubation to extubation and into the immediate postoperative period. Anesthetic goals include the prevention of perioperative hypoxemia and postoperative ALI. PMID: 25389025 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - November 12, 2014 Category: Anesthesiology Authors: Brassard CL, Lohser J, Donati F, Bussières JS Tags: Can J Anaesth Source Type: research

The amphibious fish Kryptolebias marmoratus uses different strategies to maintain oxygen delivery during aquatic hypoxia and air exposure [RESEARCH ARTICLES]
Andy J. Turko, Cayleih E. Robertson, Kristin Bianchini, Megan Freeman, and Patricia A. Wright Despite the abundance of oxygen in atmospheric air relative to water, the initial loss of respiratory surface area and accumulation of carbon dioxide in the blood of amphibious fishes during emersion may result in hypoxemia. Given that the ability to respond to low oxygen conditions predates the vertebrate invasion of land, we hypothesized that amphibious fishes maintain O2 uptake and transport while emersed by mounting a co-opted hypoxia response. We acclimated the amphibious fish Kryptolebias marmoratus, which are able to remain...
Source: Journal of Experimental Biology - November 12, 2014 Category: Biology Authors: Turko, A. J., Robertson, C. E., Bianchini, K., Freeman, M., Wright, P. A. Tags: RESEARCH ARTICLES Source Type: research

IL-6 Receptor α Defines Effector Memory CD8(+) T Cells Producing Th2 Cytokines and Expanding in Asthma.
Conclusions: Human IL-6Rαhigh EM CD8+ T cells is a unique cell subset that may serve as a reservoir for effector CD8+ T cells, particularly the ones producing Th2-type cytokines, and expand in asthma. PMID: 25390970 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2014 Category: Respiratory Medicine Authors: Lee N, You S, Shin MS, Lee WW, Kang KS, Kim SH, Kim WU, Homer RJ, Kang MJ, Montgomery RR, Dela Cruz CS, Shaw AC, Lee PJ, Chupp GL, Hwang D, Kang I Tags: Am J Respir Crit Care Med Source Type: research

Cigarette Smoking Impairs Human Pulmonary Immunity to Mycobacterium tuberculosis.
Conclusions: In smokers, the pulmonary compartment has a number of macrophage-specific immune impairments which provide some mechanistic explanations whereby cigarette smoking renders a patient susceptible to tuberculosis infection and disease. PMID: 25390734 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2014 Category: Respiratory Medicine Authors: O'Leary SM, Coleman MM, Chew WM, Morrow C, McLaughlin AM, Gleeson LE, O'Sullivan MP, Keane J Tags: Am J Respir Crit Care Med Source Type: research

Extensive Phenotyping of Individuals At-risk for Familial Interstitial Pneumonia Reveals Clues to the Pathogenesis of Interstitial Lung Disease.
Conclusions: Evidence of lung parenchymal remodeling and epithelial dysfunction were identified in asymptomatic individuals at-risk for FIP. Together, these findings offer new insights into the early pathogenesis of IIP and provide an ongoing opportunity to characterize presymptomatic abnormalities that predict progression to clinical disease. PMID: 25389906 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2014 Category: Respiratory Medicine Authors: Kropski JA, Pritchett JM, Zoz DF, Crossno PF, Markin C, Garnett ET, Degryse AL, Mitchell DB, Polosukhin VV, Rickman OB, Choi L, Cheng DS, McConaha ME, Jones BR, Gleaves LA, McMahon FB, Worrell JA, Solus JF, Ware LB, Lee JW, Massion PP, Zaynagetdinov R, Wh Tags: Am J Respir Crit Care Med Source Type: research

Early Pulmonary Vascular Disease in Preterm Infants at Risk for Bronchopulmonary Dysplasia.
Conclusions: Early pulmonary vascular disease is associated with the development of BPD and with late PH in preterm infants. Echocardiograms at 7 days of life may be a useful tool to identify infants at high risk for BPD and PH. PMID: 25389562 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - November 12, 2014 Category: Respiratory Medicine Authors: Mourani PM, Sontag MK, Younoszai A, Miller JI, Kinsella JP, Baker CD, Poindexter BB, Ingram DA, Abman SH Tags: Am J Respir Crit Care Med Source Type: research