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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Delirium detection using EEG: what and how to measure?
Conclusions:In a homogenous population of non-sedated cardiothoracic surgery patients, we observed that relative delta power from an eyes-closed EEG recording with only two electrodes in a frontal-parietal derivation can distinguish post-cardiothoracic surgery patients with delirium from those without. Background: Despite its frequency and impact, delirium is poorly recognized in postoperative- and critically ill patients. EEG (electroencephalography) is highly sensitive to delirium, but as currently used, it is not diagnostic. To develop an EEG-based tool for delirium detection with a limited number of electrodes, we ...
Source: Chest - August 28, 2014 Category: Respiratory Medicine Authors: van der Kooi AW, Zaal IJ, Klijn FA, Koek HL, Meijer RC, Leijten FS, Slooter AJ Tags: Chest Source Type: research

Prolonged Clonal Spreading and Dynamic Changes in Antimicrobial Resistance of Escherichia coli ST68 Among Patients Who Stayed in a Respiratory Care Ward.
Abstract We collected a total of 83 bacteremic isolates of Escherichia coli with reduced susceptibility or resistance to third generation cephalosporins (TGCs) from 2007 to 2009. Isolates were genotyped by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). The PFGE patterns revealed 2 highly correlated clusters (cluster E: 9 isolates; cluster G: 22 isolates) associated with this prolonged clonal spreading. Compared with cluster E isolates, cluster G isolates had a significantly higher rate of harboring aac(6')-Ib-cr (p < 0.05), and most of these were isolated during a later year than ...
Source: Journal of Medical Microbiology - August 28, 2014 Category: Microbiology Authors: Chen CM, Ke SC, Li CR, Chiou CS, Chang CC Tags: J Med Microbiol Source Type: research

Effects of pulmonary acid aspiration on the regional pulmonary blood flow within the first hour after injury: An observational study in rats.
CONCLUSIONS: From the first minute until fifty minutes after acid-induced acute lung injury, the PBF was consistently increased in the injured lung. These blood flow elevation was accompanied by significant hypoxemia. PMID: 25171591 [PubMed - as supplied by publisher] (Source: Clinical Hemorheology and Microcirculation)
Source: Clinical Hemorheology and Microcirculation - August 28, 2014 Category: Hematology Authors: Richter T, Bergmann R, Pietzsch J, Patrick M, Mueller, Koch T Tags: Clin Hemorheol Microcirc Source Type: research

Impact of Hypertriglyceridemia on the Outcome of Acute Biliary Pancreatitis.
CONCLUSIONS:: High TG level (≥2.26 mmol/L or 200.11 mg/mL) may be a risk factor for severe ABP and the development of systemic and local complications in ABP. PMID: 25171545 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - August 28, 2014 Category: Journals (General) Authors: Zeng Y, Zhang W, Lu Y, Huang C, Wang X Tags: Am J Med Sci Source Type: research

Early Postnatal Respiratory Viral Infection Alters Hippocampal Neurogenesis, Cell Fate, and Neuron Morphology in the Neonatal Piglet.
Abstract Respiratory viral infections are common during the neonatal period in humans, but little is known about how early-life infection impacts brain development. The current study used a neonatal piglet model as piglets have a gyrencephalic brain with growth and development similar to human infants. Piglets were inoculated with porcine reproductive and respiratory syndrome virus (PRRSV) to evaluate how chronic neuroinflammation affects hippocampal neurogenesis and neuron morphology. Piglets in the neurogenesis study received one bromodeoxyuridine injection on postnatal day (PD) 7 and then were inoculated with PR...
Source: Brain, Behavior, and Immunity - August 28, 2014 Category: Neurology Authors: Conrad MS, Harasim S, Rhodes JS, Van Alstine WG, Johnson RW Tags: Brain Behav Immun Source Type: research

Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures.
Abstract Inhalation of hexavalent chromium [Cr(VI)] is associated with increased lung cancer risk among workers in several industries, most notably chromate production workers exposed to high concentrations of Cr(VI) (≥100μg/m(3)), for which clear exposure-response relationships and respiratory irritation and tissue damage have been reported. Data from this industry are used to assess lung cancer risk associated with environmental and current occupational exposures, occurring at concentrations that are significantly lower (approximately a million-fold). There is considerable uncertainty in the low dose extrapola...
Source: Toxicology - August 28, 2014 Category: Toxicology Authors: Proctor DM, Suh M, Campleman SL, Thompson CM Tags: Toxicology Source Type: research

Molecular and epidemiological study of human parechovirus infections in Taiwan, 2007-2012.
CONCLUSION: This study showed that HPeVs have been endemic in Taiwan for some years despite a low positive rate. The detection tests of HPeVs are needed to correct a diagnostic deficit in the surveillance system. The epidemiological and genetic information obtained from the present study would contribute to the understanding of the etiology and epidemiology of HPeVs. PMID: 25174670 [PubMed - as supplied by publisher] (Source: Journal of Microbiology, Immunology, and Infection)
Source: Journal of Microbiology, Immunology, and Infection - August 28, 2014 Category: Microbiology Authors: Huang YP, Hsieh JY, Wu HS, Yang JY Tags: J Microbiol Immunol Infect Source Type: research

Non cystic fibrosis bronchiectasis: A longitudinal retrospective observational cohort study of Pseudomonas persistence and resistance
The hallmark of non-cystic fibrosis bronchiectasis is recurrent bronchial infection, yet there are significant gaps in our understanding of pathogen persistence, resistance and exacerbation frequencies. Pseudomonas aeruginosa is a key pathogen thought to be a marker of disease severity and progression, yet little is known if the infection risk is seen in those with milder disease or if there is any potential for eradication. These data are important in determining risk stratification and follow up. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 28, 2014 Category: Respiratory Medicine Authors: Melissa J. McDonnell, Hannah R. Jary, Audrey Perry, James G. MacFarlane, Katy L.M. Hester, Therese Small, Catherine Molyneux, John D. Perry, Katherine E. Walton, Anthony De Soyza Source Type: research

The efficacy of aerobic training in improving the inflammatory component of asthmatic children. Randomized trial
This study evaluated the effect of aerobic exercise on inflammation, functional capacity, respiratory muscle strength, quality of life and symptoms scores in asthmatic children.This was a 6-week randomized trial (NCT0192052) of 33 moderately asthmatic children (6–17 years).Patients were randomized aerobic training (exercise group; n = 14), while another group did not exercise (control; n = 19). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 28, 2014 Category: Respiratory Medicine Authors: Lívia Barboza de Andrade, Murilo C.A. Britto, Norma Lucena-Silva, Renan Garcia Gomes, José N. Figueroa Source Type: research

Hypermutation in Burkholderia cepacia complex is mediated by DNA mismatch repair inactivation and is highly prevalent in cystic fibrosis chronic respiratory infection.
In conclusion, in the present study we demonstrate for the first time that, MRS-deficient Bcc species mutators are highly prevalent and positively selected in CF chronic lung infections. Hypermutation therefore, might be playing a key role in increasing bacterial adaptability to the CF-airway environment, facilitating the persistence of chronic lung infections. PMID: 25217078 [PubMed - as supplied by publisher] (Source: International Journal of Medical Microbiology)
Source: International Journal of Medical Microbiology - August 28, 2014 Category: Microbiology Authors: Martina P, Feliziani S, Juan C, Bettiol M, Gatti B, Yantorno O, Smania AM, Oliver A, Bosch A Tags: Int J Med Microbiol Source Type: research

Socioeconomic inequalities in smoking habits are still increasing in Italy
Conclusion: Smoking prevalence has declined in Italy during the last decade among the higher socioeconomic classes, but not among the lower. This enlarging socioeconomic inequality mainly reflects a different trend in smoking initiation. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - August 27, 2014 Category: Consumer Health News Authors: Giuseppe VerlatoSimone AccordiniGiang NguyenPierpaolo MarchettiLucia CazzolettiMarcello FerrariLeonardo AntonicelliFrancesco AttenaValeria BellisarioRoberto BonoLamberto BriziarelliLucio CasaliAngelo Guido CorsicoAlessandro FoisMariaGrazia PanicoPavilio P Source Type: research

Out of the frying pan into the fire--the never forgiving complex congenital heart: a case of liquefied splenic infarct post-electrophysiology ablation
A 36-year-old man born with pulmonary atresia intact ventricular septum, atrial septal defect and Ebstein anomaly with hypoplastic right heart (figure 1 and online supplementary video). Waterson shunt had been performed in childhood, but over a period of time it had occluded with pulmonary circulation being dependent on bronchopulmonary collaterals. He is on targeted therapy for pulmonary hypertension. He was symptomatic with intermittent focal atrial tachycardia, despite amiodarone therapy. Coumarin therapy was avoided due to risk of massive haemoptysis. At electrophysiology, he had an atrial flutter circuit, which was re...
Source: Heart Asia - August 27, 2014 Category: Cardiology Authors: Rafiq, I., Deaville-Lees, D., Freeman, L. J. Tags: Images in cardiovascular medicine Source Type: research

Nasal and ocular amyloidosis in a 15-year-old horse
Localized nasal, conjunctival and corneal amyloidosis was diagnosed in a 15-year-old pony with nasal and conjunctival masses and severe dyspnoea. Multiple swellings had been evident in the nostrils for at least two years and had gradually increased in size before presentation due to dyspnoea and exercise intolerance. Surgical debulking of the masses was performed and histological examination revealed large amounts of extracellular, hyaline, eosinophilic, Congo red positive material in the lamina propria of the nasal mucosa. A tentative diagnosis of localized nasal amyloidosis was made. The treatment relieved the clinical s...
Source: Acta Veterinaria Scandinavica - August 27, 2014 Category: Veterinary Research Authors: Liv ØstevikGjermund GunnesGustavo de SouzaTale WienRandi Sørby Source Type: research

Purified deoxynivalenol or feed restriction reduces mortality in rainbow trout, Oncorhynchus mykiss (Walbaum), with experimental bacterial coldwater disease but biologically relevant concentrations of deoxynivalenol do not impair the growth of Flavobacterium psychrophilum
Abstract Diets containing deoxynivalenol (DON) were fed to rainbow trout Oncorhynchus mykiss (Walbaum) for 4 weeks followed by experimental infection (intraperitoneal) with Flavobacterium psychrophilum (4.1 × 106 colony‐forming units [CFU] mL−1). Mortality of rainbow trout fed either 6.4 mg kg−1 DON or trout pair‐fed the control diet was significantly reduced (P < 0.05) in comparison with trout fed the control diet to apparent satiation (<0.1 mg kg−1 DON). In a second experiment, trout were fed one of three experimental diets; a control diet, a diet produced with corn naturally contaminated with ...
Source: Journal of Fish Diseases - August 27, 2014 Category: Zoology Authors: I A Ryerse, J M Hooft, D P Bureau, M A Hayes, J S Lumsden Tags: Original Article Source Type: research

Complete coding regions of the prototypes enterovirus B93 and C95: Phylogenetic analyses of the P1 and P3 regions of EV‐B and EV‐C strains
Complete coding regions were sequenced for two new enterovirus genomes: EV‐B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV‐C95 from a French soldier with acute gastroenteritis in Djibouti. The EV‐B93 P1 had more than 30% nucleotide divergence from other EV‐B types, with highest similarity to E‐15 and EV‐B80. The P1 nucleotide sequence of EV‐C95 was most similar, 71%, to CV‐A21. Complete coding regions for the new enteroviruses were compared with those of 135 EV‐B and 176 EV‐C strains representing all types availab...
Source: Journal of Medical Virology - August 27, 2014 Category: Virology Authors: N. Junttila, N. Lévêque, L.O. Magnius, J.P. Kabue, J. J. Muyembe‐Tamfum, J. Maslin, B. Lina, H. Norder Tags: Research Article Source Type: research

Sequential infusion of donor‐derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation
Donor lymphocyte infusion (DLI) is often given to induce a graft‐versus‐leukemia (GVL) effect after allogeneic hematopoietic stem cell transplantation (HSCT). However, efficacy of DLI is limited in most hematologic cancers. As antigen presenting cells, dendritic cells (DC) bolster immune responses. We conducted a Phase I trial testing the coinfusion of DC followed by DLI. DC were generated by culturing peripheral blood mononuclear cells from HLA matched‐related donors in GM‐CSF and IL‐4 for 7 days, followed by TNF‐α for 3 days. DC were administered intravenously on 3 dose levels (5 × 106; 1 × 107; 5 × 107 c...
Source: American Journal of Hematology - August 27, 2014 Category: Hematology Authors: Vincent T. Ho, Haesook T. Kim, Grace Kao, Corey Cutler, James Levine, Jacalyn Rosenblatt, Robin Joyce, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, David Avigan, Edwin P. Alyea Tags: Research Article Source Type: research

Evidence for multiple sensory circuits in the brain arising from the respiratory system: an anterograde viral tract tracing study in rodents.
Abstract Complex sensations accompany the activation of sensory neurons within the respiratory system, yet little is known about the organization of sensory pathways in the brain that mediate these sensations. In the present study, we employ anterograde viral neuroanatomical tract tracing with isogenic self-reporting recombinants of HSV-1 strain H129 to map the higher brain regions in receipt of vagal sensory neurons arising from the trachea versus the lungs, and single-cell PCR to characterize the phenotype of sensory neurons arising from these two divisions of the respiratory tree. The results suggest that the up...
Source: Brain Structure and Function - August 27, 2014 Category: Neuroscience Authors: McGovern AE, Davis-Poynter N, Yang SK, Simmons DG, Farrell MJ, Mazzone SB Tags: Brain Struct Funct Source Type: research

A randomised controlled double‐blind clinical trial of 17‐hydroxyprogesterone caproate for the prevention of preterm birth in twin gestation (PROGESTWIN): evidence for reduced neonatal morbidity
ConclusionsIntramuscular 17OHPC therapy did not reduce PTB before 37 weeks of gestation in unselected twin pregnancies. Nonetheless, 17OHPC significantly reduced neonatal morbidity parameters and increased birthweight. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)
Source: BJOG: An International Journal of Obstetrics and Gynaecology - August 27, 2014 Category: OBGYN Authors: J Awwad, IM Usta, G Ghazeeri, N Yacoub, J Succar, S Hayek, W Saasouh, AH Nassar Tags: Original Article Source Type: research

The OPTIMIST-A trial: evaluation of minimally-invasive surfactant therapy in preterm infants 25-28 weeks gestation
DiscussionMinimally-invasive surfactant therapy has the potential to ease the burden of respiratory morbidity in preterm infants. The trial will provide definitive evidence on the effectiveness of this approach in the care of preterm infants born at 25-28 weeks gestation.Trial registration: Australia and New Zealand Clinical Trial Registry: ACTRN12611000916943; ClinicalTrials.gov: NCT02140580. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - August 27, 2014 Category: Pediatrics Authors: Peter DargavilleCamille KamlinAntonio De PaoliJohn CarlinFrancesca OrsiniRoger SollPeter Davis Source Type: research

Measures of cardiorespiratory fitness in relation to measures of body size and composition among children
ConclusionsWhile assessing cardiorespiratory fitness, LM is the most appropriate measure of body size or composition for scaling of WMAX and VO2MAX, because scaling by body weight introduces confounding by body adiposity. (Source: Clinical Physiology and Functional Imaging)
Source: Clinical Physiology and Functional Imaging - August 27, 2014 Category: Radiology Authors: Tuomo Tompuri, Niina Lintu, Kai Savonen, Tomi Laitinen, David Laaksonen, Jarmo Jääskeläinen, Timo A. Lakka Tags: Original Article Source Type: research

Combined T2‐preparation and two‐dimensional pencil‐beam inner volume selection
ConclusionWhen compared with conventional T2‐Prep, the 2D‐T2‐Prep improves vessel sharpness and decreases respiratory ghosting while preserving both SNR and CNR. It may also acquire rFoV images for accelerated data acquisition. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - August 27, 2014 Category: Radiology Authors: Andrew J Coristine, Ruud B van Heeswijk, Matthias Stuber Tags: Note Source Type: research

A clinical in-hospital prognostic score for acute exacerbations of COPD
Conclusions: A score using simple clinical variables has robust properties for predicting the risk of in-hospital death in patients hospitalized for AECOPD. Adding cardiac comorbidities to the original score increased its sensitivity. (Source: Respiratory Research)
Source: Respiratory Research - August 27, 2014 Category: Respiratory Medicine Authors: Nicolas RocheJean-Michel ChavaillonCyril MaurerMahmoud ZureikJacques Piquet Source Type: research

Small airway dysfunction is associated to excessive bronchoconstriction in asthmatic patients
Background: We investigated whether a relationship between small airways dysfunction and bronchial hyperresponsiveness (BHR), expressed both in terms of ease of airway narrowing and of excessive bronchoconstriction, could be demonstrated in asthma. Methods: 63 (36?F; mean age 42?yr???14) stable, mild-to-moderate asthmatic patients (FEV1 92% pred ?14; FEV1/FVC 75%???8) underwent the methacholine challenge test (MCT). The degree of BHR was expressed as PD20 (in ?g) and as ?FVC%. Peripheral airway resistance was measured pre- and post-MCT by impulse oscillometry system (IOS) and expressed as R5-R20 (in kPa sL?1). Results: All...
Source: Respiratory Research - August 27, 2014 Category: Respiratory Medicine Authors: Veronica AlfieriMarina AielloRoberta PisiPanagiota TzaniElisa MarianiEmilio MarangioDario OlivieriGabriele NicoliniAlfredo Chetta Source Type: research

Self-management support interventions to reduce health care utilisation without compromising outcomes: a systematic review and meta-analysis
Conclusions: Self-management support interventions can reduce health service utilization without compromising patient health outcomes, although effects were generally small, and the evidence was strongest in respiratory and cardiovascular disorders. Further work is needed to determine which components of self-management support are most effective. (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 27, 2014 Category: Journals (General) Authors: Maria PanagiotiGerry RichardsonNicola SmallElizabeth MurrayAnne RogersAnne KennedyStanton NewmanPeter Bower Source Type: research

Intrapartum and neonatal outcome of screening non‐stress test (NST) compared with no screening NST in healthy women at 40–40 (+6) weeks of gestation
ConclusionRoutine performing NST at the gestational age of 40–40+6 weeks has no benefit in intrapartum and neonatal outcome. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - August 27, 2014 Category: OBGYN Authors: Patcharin Kiettisanpipop, Vorapong Phupong Tags: Original Article Source Type: research

Cervical vertebrae maturation, dentoalveolar, head postural and respiratory parameters in predicting the stable outcome of face-mask treatment.
CONCLUSIONS/IMPLICATIONS: Presence of non-skeletal cephalometric factors more closely associated with stability of face-mask treatment rather than skeletal cephalometric factors at the initial stage are confirmed. PMID: 25164062 [PubMed - as supplied by publisher] (Source: European Journal of Orthodontics)
Source: European Journal of Orthodontics - August 27, 2014 Category: Dentistry Authors: Lee KM, Chung DH, Lee JW, Lee SM Tags: Eur J Orthod Source Type: research

A randomised controlled double-blind clinical trial of 17-hydroxyprogesterone caproate for the prevention of preterm birth in twin gestation (PROGESTWIN): evidence for reduced neonatal morbidity.
CONCLUSIONS: Intramuscular 17OHPC therapy did not reduce PTB before 37 weeks of gestation in unselected twin pregnancies. Nonetheless, 17OHPC significantly reduced neonatal morbidity parameters and increased birthweight. PMID: 25163819 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - August 27, 2014 Category: OBGYN Authors: Awwad J, Usta I, Ghazeeri G, Yacoub N, Succar J, Hayek S, Saasouh W, Nassar A Tags: BJOG Source Type: research

Veterans With Chronic Obstructive Pulmonary Disease Achieve Clinically Relevant Improvements in Respiratory Health After Pulmonary Rehabilitation.
CONCLUSIONS:: Pulmonary rehabilitation improves respiratory health in veterans with chronic obstructive pulmonary disease and decreases RR health care utilization. PMID: 25166259 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - August 27, 2014 Category: Rehabilitation Authors: Major S, Moreno M, Shelton J, Panos RJ Tags: J Cardiopulm Rehabil Prev Source Type: research

The Role of Stepdown Beds in Hospital Care.
Abstract Stepdown beds provide an intermediate level of care for patients with requirements somewhere between that of the general ward and the intensive care unit. Models of care include incorporation of step-down beds into intensive care units, stand-alone units, or incorporation of beds into standard wards. Stepdown beds may be used to provide a higher level of care for patients deteriorating on a ward ("step-up"), a lower level of care for patients transitioning out of intensive care ("step-down") or a lateral transfer of care from a recovery room for post-operative patients. These units are one possible strateg...
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Prin M, Wunsch H Tags: Am J Respir Crit Care Med Source Type: research

Autologous Transfusion of Stored Red Blood Cells Increases Pulmonary Artery Pressure.
Conclusions: Transfusion of autologous leukoreduced blood stored for 40-days was associated with increased plasma hemoglobin levels and increased pulmonary artery pressure. Breathing nitric oxide prevents the increase of pulmonary artery pressure produced by transfusing stored blood. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01529502. PMID: 25162920 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Berra L, Pinciroli R, Stowell CP, Wang L, Yu B, Fernandez BO, Feelisch M, Mietto C, Hod EA, Chipman D, Scherrer-Crosbie M, Bloch KD, Zapol WM Tags: Am J Respir Crit Care Med Source Type: research

Seeking Worldwide Professional Consensus on the Principles of End-of-life Care for the Critically Ill: The Welpicus Study.
CS, Avidan A PMID: 25162767 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Sprung CL, Truog RD, Curtis JR, Joynt GM, Baras M, Michalsen A, Briegel J, Kesecioglu J, Efferen L, De Robertis E, Bulpa P, Metnitz P, Patil N, Hawryluck L, Manthous C, Moreno R, Leonard S, Hill NS, Wennberg E, McDermid RC, Mikstacki A, Mularski RA, Harto Tags: Am J Respir Crit Care Med Source Type: research

Lipoxin Generation is Related to Soluble Epoxide Hydrolase Activity in Severe Asthma.
Conclusions: Lipoxin levels were decreased by oxidative stress and sEH activity. Inhibitors of sEH increased LXs that mediated anti-phlogistic actions, suggesting a new therapeutic approach for severe asthma. Clinical trial registration available at www.clinicaltrials.gov, ID NCT00595114. PMID: 25162465 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock B, Douda D, Tabet Y, Sirois M, Sirois C, Rizcallah E, Rousseau E, Israel E, Levy BD, Ameredes BT, Bleecker E, Calhoun WJ, Cherniack R, Chinchilli VM, Craig TJ, Denlinger L, DiMango E, Fahy J, Icitovi Tags: Am J Respir Crit Care Med Source Type: research

IL-17 in Severe Asthma: Where Do We Stand?
Abstract Asthma is a major chronic disease ranging from mild to severe refractory disease and is classified into various clinical phenotypes. Severe asthma is difficult to treat and frequently requires high doses of systemic steroids. In some cases, severe asthma even responds poorly to steroids. Several studies have suggested a central role of IL-17 (also called IL-17A) in severe asthma. Indeed, high levels of IL-17 are found in induced sputum and bronchial biopsies obtained from severe asthmatics. The recent identification of a steroid-insensitive pathogenic TH17 pathway is therefore of major interest. In additio...
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Chesné J, Braza F, Mahay G, Brouard S, Aronica M, Magnan A Tags: Am J Respir Crit Care Med Source Type: research

Epidemiological Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences.
Conclusions: The status of IPF in the Japanese population was clarified for the first time through our study. Our results showed that in men, the incidence of death due to acute exacerbation was higher and that due to cardiovascular disease was lower in Japan than in Western countries. These results may suggest ethnic differences in IPF. PMID: 25162152 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H Tags: Am J Respir Crit Care Med Source Type: research

A clinical in-hospital prognostic score for acute exacerbations of COPD.
ConclusionsA score using simple clinical variables has robust properties for predicting the risk of in-hospital death in patients hospitalized for AECOPD. Adding cardiac comorbidities to the original score increased its sensitivity. PMID: 25158759 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 27, 2014 Category: Respiratory Medicine Authors: Roche N, Chavaillon JM, Maurer C, Zureik M, Piquet J Tags: Respir Res Source Type: research

Physiological responses of a rodent to helox reveal constancy of evaporative water loss under perturbing environmental conditions.
We present here evidence, based on the first measurements of evaporative water loss for a small mammal in helox, that mammals may have a previously unappreciated ability to maintain acute constancy of total evaporative water loss under perturbing environmental conditions. Thermoregulatory responses of ash-grey mice (Pseudomys albocinereus) to helox were as expected, with changes in metabolic rate, conductance and respiratory ventilation consistent with maintaining constancy of body temperature under conditions of enhanced heat loss. However, evaporative water loss did not increase in helox. This is despite our confirmation...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 27, 2014 Category: Physiology Authors: Cooper CE, Withers PC Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Dietary milk fat globule membrane improves endurance capacity in mice.
Abstract Milk fat globule membrane (MFGM) comprises carbohydrates, membrane-specific proteins, glycoproteins, phospholipids, and sphingolipids. We evaluated the effects of MFGM consumption over a 12-week period on endurance capacity and energy metabolism in BALB/c mice. Long-term MFGM intake combined with regular exercise improved endurance capacity, as evidenced by swimming time until fatigue, in a dose-dependent manner. The effect of dietary MFGM plus exercise was accompanied by higher oxygen consumption and lower respiratory quotient, as determined by indirect calorimetry. MFGM intake combined with exercise incr...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 27, 2014 Category: Physiology Authors: Haramizu S, Ota N, Otsuka A, Hashizume K, Sugita S, Hase T, Murase T, Shimotoyodome A Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Stenotrophomonas maltophilia in Mexico: antimicrobial resistance, biofilm formation, and clonal diversity.
Abstract Stenotrophomonas maltophilia is an important multidrug-resistant nosocomial pathogen associated with high mortality. Our aim is to examine antimicrobial susceptibility, biofilm production, and clonal relatedness of clinical isolates of S. maltophilia. S. maltophilia isolates were collected between 2006 and 2013 from two tertiary-care hospitals in Mexico. Antimicrobial susceptibility was evaluated by the broth microdilution method. PCR was used to determine the presence of β-lactamase genes L1 and L2. Biofilm formation was assessed with crystal violet staining. Clonal relatedness was determined by pulsed-f...
Source: Journal of Medical Microbiology - August 27, 2014 Category: Microbiology Authors: Flores-Treviño S, Gutiérrez-Ferman JL, Morfín-Otero R, Rodríguez-Noriega E, Estrada-Rivadeneyra D, Rivas-Morales C, Llaca-Díaz JM, Camacho-Ortíz A, Mendoza-Olazarán S, Garza-González E Tags: J Med Microbiol Source Type: research