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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Therapeutic potential and mechanisms of action of Mesenchymal Stromal Cells for Acute Respiratory Distress Syndrome.
Abstract Mesenchymal stem/stromal cells (MSCs) have become the focus of intense research effort over the past 10 years, in an effort to harness their regenerative and immune-modulating capacity for a variety of clinical conditions. In Acute Respiratory Distress Syndrome (ARDS), pre-clinical studies point towards a therapy that modulates multiple aspects of a complex disease process. Almost universally, these cells have demonstrated an immune modulating phenotype, balancing protective host responses with a reduction in damaging inflammation, while enhancing bacterial killing. MSCs also lead to more efficient tissue ...
Source: Current Stem Cell Research and Therapy - February 28, 2014 Category: Stem Cells Authors: Curley GF, Scott JA, Laffey JG Tags: Curr Stem Cell Res Ther Source Type: research

ECLS for preemies: The artificial placenta
Abstract: The high mortality and morbidity associated with respiratory failure among extremely low gestational age newborns (ELGANs) remains an unsolved problem. A logical strategy to avoid these complications would involve re-creating the intrauterine environment with extracorporeal membrane oxygenation (ECMO) instead of mechanical ventilation. Such a device, termed an artificial placenta, was first researched over 50 years ago. AP models vary, but all incorporate ECMO involving the umbilical vessels, lack of mechanical ventilation, and low partial pressure of oxygen to preserve fetal circulation. Current research has foc...
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Benjamin S. Bryner, George B. Mychaliska Source Type: research

ECMO in neonates: Neuroimaging findings and outcome
Abstract: Extracorporeal membrane oxygenation (ECMO) is a rescue therapy for newborns with severe but reversible respiratory failure. Although ECMO has significantly improved survival, it is associated with substantial complications, of which intracranial injuries are the most important. These injuries consist of hemorrhagic and non-hemorrhagic, ischemic lesions. Different from the classical presentation of hemorrhages in preterm infants, hemorrhages in ECMO-treated newborns are mainly parenchymal and with a high percentage in the posterior fossa area. There are conflicting data on the predominant occurrence of cerebral le...
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Arno F.J. van Heijst, Amerik C. de Mol, Hanneke IJsselstijn Source Type: research

Update on PPHN: Mechanisms and treatment
Abstract: Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen in term and near-term infants, it can be recognized in some premature infants with respiratory distress or bronchopulmonary dysplasia. Most commonly, PPHN is secondary to delayed or impaired relaxation of the pulmonary vasculature associated with diverse neonatal pulmonary pathologies, such as meconium aspiration syndrome, congenital diaphragmatic hernia, and respiratory distress syndrome. Gentle ventilation strategies, lung recruitment, i...
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Jayasree Nair, Satyan Lakshminrusimha Source Type: research

Venoarterial versus venovenous ECMO for neonatal respiratory failure
This article reviews the development of the two types of extracorporeal support, venoarterial and venovenous ECMO, and discusses the advantages of each method, the current selection criteria, the procedure, and the clinical management of neonates on ECMO. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Khodayar Rais-Bahrami, Krisa P. Van Meurs Source Type: research

Update and outcomes in extracorporeal life support
Abstract: The Extracorporeal Life Support Organization Registry has collected outcome data of almost 56,000 patients receiving extracorporeal life support (ECLS) over the last 24 years. The use of neonatal respiratory ECLS declined from a peak of 1516 cases in 1992 to 750–865 cases from 2008 to 2012. The 26,583 cases of neonatal respiratory ECLS (75% survival) represent the largest patient population in the registry. Indicating the rapid growth in other patient populations, 2013 marks the first year where the number of neonatal respiratory ECLS cases is less than 50% of the registry. Stagnant at ~200 cases/year from 1993...
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Matthew L. Paden, Peter T. Rycus, Ravi R. Thiagarajan, on Behalf of the ELSO Registry Source Type: research

Preface
As with all historic events, there are many crossroads that occur, with key elements and/or people at each turn, directing the movement forward. In the late 1940 and early 1950s the fields of cardiovascular surgery and nephrology were emerging, with leaders in the fields working on artificial systems to support the heart for cardiac surgery and the kidney during renal failure. In 1944, investigators working on an artificial membrane for dialysis observed that blood became oxygenated as it passed through the cellophane chambers of their membrane. This historic observation led to the recognition by those involved in the fast...
Source: Seminars in Perinatology - February 27, 2014 Category: Perinatology & Neonatology Authors: Billie Lou Short Source Type: research

ONY Inc. to market treatment for premature infants
ONY Inc. has signed a deal with Recordati Rare Diseases to co-promote a second product to treat health problems in premature babies. The deal allows the Amherst life sciences company to market NeoProfen injections, a treatment for Patent Ductus Arteriosus heart problems in infants 32 weeks or younger. ONY’s main product is Infasurf, a lung treatment used to prevent and treat respiratory distress in premature infants. Terms of the Recordati deal were not disclosed, but company executives called… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 27, 2014 Category: Biotechnology Authors: Tracey Drury Source Type: research

Acknowledgement to Reviewers 2013
(Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - February 27, 2014 Category: Respiratory Medicine Source Type: research

Patterns and determinants of COPD-related healthcare utilization by severity of airway obstruction in Korea
Conclusions: This study ascertained marked underdiagnosed COPD. Although the percentage of prescribed medication used to treat COPD increased with the severity of the COPD, medications primarily prescribed such as oral theophylline or oral corticosteroids are inappropriate for first-line COPD treatment. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 27, 2014 Category: Respiratory Medicine Authors: Kyungsoo ChungKyungjoo KimJiye JungKyungwon OhYeonmok OhSekyu KimJinhee KimYoungsam Kim Source Type: research

Quality of life is associated with physical activity and fitness in cystic fibrosis
Conclusions: HRQoL was associated with physical fitness, especially aerobic fitness, and to a lesser extent with reported physical activity. These findings underline the importance of physical fitness for HRQoL in CF and provide an additional rationale for exercise testing in this population.Trial registration: ClinicalTrials.gov NCT00231686 (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 27, 2014 Category: Respiratory Medicine Authors: Helge HebestreitKerstin SchmidStephanie KieserSibylle JungeManfred BallmannKristina RothAlexandra HebestreitThomas SchenkChristian SchindlerHans-Georg PosseltSusi Kriemler Source Type: research

Application of a photogrammetric kinematic model for prediction of lung volumes in adolescents: a pilot study
Conclusions: Photogrammetry can be used to study thoracoabdominal movements by applying analytical two-dimensional and three-dimensional images acquired using a video camera being, applicable and reproducible. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 27, 2014 Category: Epidemiology Authors: Wagner L RipkaLeandra UlbrichtPedro M Gewehr Source Type: research

The Effect of Methylnaltrexone on the Side Effects of Intrathecal Morphine after Orthopedic Surgery under Spinal Anesthesia
This study has been designed to evaluate the effect of methylnaltrexone on postoperative side effects of intrathecal morphine. In seventy‐two 18‐ to 55‐year‐old patients scheduled for elective orthopedic operations under spinal anesthesia, neuraxial blockade was achieved using 10 mg 0.5% hyperbaric bupivacaine and 0.1 mg preservative‐free morphine sulfate. The first group (M) received 12 mg methylnaltrexone, while the second group (P) received normal saline, subcutaneously, immediately after spinal block in a randomized, double‐blind fashion. There was a significant decrease in the rate of nausea and vomitin...
Source: Pain Practice - February 27, 2014 Category: Anesthesiology Authors: Farid Zand, Afshin Amini, Saman Asadi, Arash Farbood Tags: Original Article Source Type: research

Knowledge, attitudes, and practices of parents in rural China on the use of antibiotics in children: a cross-sectional study
Conclusions: Low levels of knowledge on the use of antibiotics and a high prevalence of self-medicating children with antibiotics were observed among parents in rural China. Interventions for the rational use of antibiotics in children should focus on strengthening mass health education, improving effective communication between physicians and patients, and enforcing supervision of the sale of antibiotics in retail pharmacies. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 27, 2014 Category: Infectious Diseases Authors: Miao YuGenming ZhaoCecilia Stålsby LundborgYipin ZhuQi ZhaoBiao Xu Source Type: research

Outcome of acute East African trypanosomiasis in a Polish traveller treated with pentamidine
Conclusion: Sleeping sickness should always be considered in the differential diagnosis of fever in people returning from safari trips to the national parks or nature reserves of sub-Saharan Africa. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 27, 2014 Category: Infectious Diseases Authors: Ma¿gorzata PaulJerzy StefaniakPiotr SmuszkiewiczMarjan Van EsbroeckDirk GeysenJan Clerinx Source Type: research

Extensive protein hydrolysate formula effectively reduces regurgitation in infants with positive and negative challenge tests for cow's milk allergy
ConclusioneCH fulfilled the criteria for a hypoallergenic formula and the NT‐eCH and T‐eCH formulas both reduced CMPA symptoms. The symptom‐based score is useful for evaluating how effective dietary treatments are for CMPA.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - February 27, 2014 Category: Pediatrics Authors: Y. Vandenplas, E. Greef, Tags: Regular Article Source Type: research

Highly efficient respiratory motion compensated free‐breathing coronary mra using golden‐step Cartesian acquisition
ConclusionWe demonstrate the feasibility of a new 3D affine respiratory motion correction technique for Cartesian whole‐heart CMRA that achieves 100% scan efficiency and therefore a predictable acquisition time. This approach yields image quality comparable to that of an 8‐mm navigator‐gated acquisition with lower scan efficiency. Further evaluation of this technique in patients is now warranted to determine its clinical use.J. Magn. Reson. Imaging 2014;. © 2014 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - February 27, 2014 Category: Radiology Authors: Claudia Prieto, Mariya Doneva, Muhammad Usman, Markus Henningsson, Gerald Greil, Tobias Schaeffter, Rene M. Botnar Tags: Technical Note Source Type: research

Airway, but not serum or urinary, levels of YKL-40 reflect inflammation in early cystic fibrosis lung disease
Conclusions: This study demonstrates that levels of the chitinase-like protein YKL-40 reflect airway inflammation and infection in early CF lung disease. The lack of increased YKL-40 in serum in the absence of systemic inflammation limits the benefit of this potential biomarker in early disease. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 27, 2014 Category: Respiratory Medicine Authors: Emmanuelle FantinoCatherine GangellDominik HartlPeter Sly Source Type: research

Anaesthetic, analgesic and cardiorespiratory effects of intramuscular medetomidine‐ketamine combination alone or with morphine or tramadol for orchiectomy in cats
Conclusion and clinical relevanceAll three protocols can provide adequate anaesthesia and analgesia for orchiectomy in cats. However, rescue intervention to maintain surgical anaesthesia may be required in some cats. Oxygen supplementation is advised. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - February 27, 2014 Category: Veterinary Research Authors: Gareth E Zeiler, Brighton T Dzikiti, Geoffrey T Fosgate, Frik G Stegmann, Frans J Venter, Eva Rioja Tags: Research Paper Source Type: research

Hyoscine‐N‐butylbromide premedication on cardiovascular variables of horses sedated with medetomidine
Conclusion and clinical relevanceHyoscine administered IV or IM before medetomidine in horses resulted in tachycardia and hypertension under the conditions of this study. The significance of these changes, and responses to other dose rates, requires further investigation. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - February 27, 2014 Category: Veterinary Research Authors: João H Perotta, Paulo A Canola, Maristela CS Lopes, Patrícia M Évora, Paulo EB Martinez, André Escobar, Carlos AA Valadão Tags: Research Paper Source Type: research

Minimum infusion rate of alfaxalone for total intravenous anaesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy
Conclusion and clinical relevanceAlfaxalone TIVA in cats after medetomidine or acepromazine sedation provided suitable anaesthesia with no need for ventilatory support. After these premedications, the authors recommend initial alfaxalone TIVA rates of 10 mg kg−1 hour−1. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - February 27, 2014 Category: Veterinary Research Authors: Andrea Schwarz, Karin Kalchofner, Julia Palm, Stephanie Picek, Sonja Hartnack, Regula Bettschart‐Wolfensberger Tags: Research Paper Source Type: research

Stabilization of Respiratory Supercomplexes [Bioenergetics]
This study presents the first evidence showing that supercomplexes can be stabilized by the stimulated formation of CcO. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - February 27, 2014 Category: Chemistry Authors: Cui, T.-Z., Conte, A., Fox, J. L., Zara, V., Winge, D. R. Tags: Bioenergetics Source Type: research

Evaluation of Renal Functions in Preterm Infants With Respiratory Distress Syndrome
ConclusionPreterm infants with RDS had increased levels of both GST‐π and B2‐MG levels on PN day 30, suggesting subclinical tubular dysfunction, probably secondary to hypoxic stress. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 27, 2014 Category: Laboratory Medicine Authors: Yılmaz Tabel, Mehmet Öncül, Ahmet Taner Elmas, Serdal Güngör Tags: Original Article Source Type: research

Innate immune recognition of respiratory syncytial virus infection.
Abstract Respiratory syncytial virus (RSV) is the leading cause of respiratory infection in infants and young children. Severe clinical manifestation of RSV infection is a bronchiolitis, which is common in infants under six months of age. Recently, RSV has been recognized as an important cause of respiratory infection in older populations with cardiovascular morbidity or immunocompromised patients. However, neither a vaccine nor an effective antiviral therapy is currently available. Moreover, the interaction between the host immune system and the RSV pathogen during an infection is not well understood. The innate i...
Source: BMB Reports - February 27, 2014 Category: Biochemistry Authors: Kim TH, Lee HK Tags: BMB Rep Source Type: research

[Prehospital non-invasive ventilation in Germany : Results of a nationwide survey of ground-based emergency medical services.]
CONCLUSION: Prehospital NIV in Germany was used by only one third of all respondents by the end of 2008. Based on the clinical data a growing application for pNIV is expected. Controlled prehospital studies are needed to enunciate evidence-based recommendations for pNIV. PMID: 24569935 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)
Source: Der Anaesthesist - February 27, 2014 Category: Anesthesiology Authors: Sellmann T, Conty C, Treschan T, Kindgen-Milles D Tags: Anaesthesist Source Type: research

Cardiopulmonary performance testing using a robotics-assisted tilt table: Feasibility assessment in able-bodied subjects.
CONCLUSIONS: The robotics-assisted tilt table is deemed feasible for peak cardiopulmonary performance testing: the approach was found to be technically implementable and substantial cardiopulmonary responses were observed. Further testing in neurologically-impaired subjects is warranted. PMID: 24576813 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - February 27, 2014 Category: Medical Equipment Authors: Saengsuwan J, Laubacher M, Nef T, Hunt KJ Tags: Technol Health Care Source Type: research

Assessing the Utility of FDG PET-CT after Stereotactic Body Radiotherapy for Early Stage Non-small Cell Lung Cancer.
CONCLUSIONS: FDG PET-CT 3 months following treatment of NSCLC with SBRT was a specific but insensitive test for detection of recurrence or treatment failure. Serial CT scans should be used for early surveillance following SBRT while reserving FDG PET-CT to define suspected metastatic disease, evaluate new abnormalities on CT scan, or possibly to reassess later in the follow up period after radiation related inflammation subsides. PMID: 24577678 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Pastis NJ, Greer TJ, Tanner NT, Whalquist AE, Gordon LL, Sharma AK, Koch NC, Silvestri GA Tags: Chest Source Type: research

Do Field Walking Tests Produce Similar Cardiopulmonary Demands to an Incremental Treadmill test in Obese Individuals with Treated Obstructive Sleep Apnea?
CONCLUSION The ISWT can be used, instead of an ITM and in preference to the 6MWT, to assess cardio-respiratory fitness for a cohort of obese people with treated OSA. However, the imprecision of the agreement in V˙O2pk between the ITM and ISWT means they cannot be used interchangeably in an individual. ClinicalTrials.gov identifier: NCT01930513. PMID: 24577643 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Evans RA, Dolmage TE, Robles PG, Goldstein RS, Brooks D Tags: Chest Source Type: research

A Tuberculosis Antigen-stimulated CXCR3 Ligand Assay for the Diagnosis of Active Pulmonary Tuberculosis.
CONCLUSIONS: TB antigen-stimulated assays of I-TAC and MIG may be useful surrogate markers for diagnosing active pulmonary TB. PMID: 24577604 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Chung WY, Lee KS, Jung YJ, Lee HL, Kim YS, Park JH, Sheen SS, Park KJ Tags: Chest Source Type: research

Laterality Defects other than Situs Inversus Totalis in Primary Ciliary Dyskinesia: Insights into Situs Ambiguus and Heterotaxy.
CONCLUSIONS: At least 12.1% of classic PCD have SA and laterality defects ranging from classic heterotaxy to subtle laterality defects. Specific clinical features of PCD and low nNO help identify PCD in patients with laterality defects. TRIAL REGISTRY: ClinicalTrials.gov: NCT00323167. PMID: 24577564 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Shapiro AJ, Davis SD, Ferkol T, Dell SD, Rosenfeld M, Olivier KN, Sagel SD, Milla C, Zariwala MA, Wolf W, Carson JL, Hazucha MJ, Burns K, Robinson B, Knowles MR, Leigh MW, for the Genetic Disorders of Mucociliary Clearance Consortium Tags: Chest Source Type: research

Feasibility and Safety of Outpatient Medical Thoracoscopy at a Large Tertiary Medical Center: A Collaborative Medical-Surgical Initiative.
CONCLUSIONS: Outpatient MT can be successfully integrated into a busy tertiary referral medical center through the combined efforts of interventional pulmonologists and thoracic surgeons. Outpatient MT may provide patients a more convenient alternative to an inpatient surgical approach in the diagnosis of undiagnosed exudative pleural effusions while maintaining a high diagnostic yield and excellent safety. PMID: 24577099 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Depew ZS, Wigle D, Mullon JJ, Nichols FC, Deschamps C, Maldonado F Tags: Chest Source Type: research

Efficacy and Safety of Early Dexmedetomidine during Non-Invasive Ventilation for Patients with Acute Respiratory Failure: A Randomized, Double-Blind, Placebo-Controlled, Pilot Study.
CONCLUSION: Initiating D soon after NIV initiation in patients with ARF neither improves NIV tolerance nor helps maintain sedation at a desired goal. Randomized, multicenter trials targeting patients with initial intolerance are needed to further elucidate the role for D in this population.This study is registered on www.ClinicalTrials.gov (# NCT 00871624). PMID: 24577019 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Devlin JW, Al-Qadheeb NS, Chi A, Roberts R, Qawi I, Garpestad E, Hill NS Tags: Chest Source Type: research

Modified criteria for the systemic inflammatory response syndrome (SIRS) improves their utility following cardiac surgery.
CONCLUSIONS: The concept of SIRS remains valid following cardiac surgery. With suitable modification its specificity can be improved significantly. We propose that meeting two or more defining criteria for 6 hours could be employed to define better populations with more difficult clinical courses following cardiac surgery. This group may merit a different clinical approach. PMID: 24576975 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Maccallum NS, Finney SJ, Gordon SE, Quinlan GJ, Evans TW Tags: Chest Source Type: research

Predictors of mortality and progression in scleroderma-associated interstitial lung disease: A systematic review.
CONCLUSIONS: Mortality and ILD progression were predicted by several patient-specific, ILD-specific and SSc-specific factors. Additional prospective studies are required to validate these preliminary findings and identify combinations of variables that accurately predict prognosis of SSc-ILD. PMID: 24576924 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - February 27, 2014 Category: Respiratory Medicine Authors: Winstone TA, Assayag D, Wilcox PG, Dunne JV, Hague CJ, Leipsic J, Collard HR, Ryerson CJ Tags: Chest Source Type: research

Is influenza-like illness a useful concept and an appropriate test of influenza vaccine effectiveness?
CONCLUSIONS: The working diagnosis of ILI presumes influenza may be involved until proven otherwise. Health care workers would benefit by renaming the WHO and CDC ILI symptoms and signs as "acute respiratory illness" and using the WHO acute severe respiratory illness definition. This renaming would shift attention to identify the viral and bacterial pathogens in cases and epidemics, identify new pathogens, implement vaccination plans appropriate to the identified pathogens, and estimate workload during the viral season. Randomised controlled trials testing the effectiveness of influenza vaccine require all participants to ...
Source: Vaccine - February 27, 2014 Category: Allergy & Immunology Authors: Thomas RE Tags: Vaccine Source Type: research

Validation of multiple‐breath washout equipment for infants and young children
ConclusionsBoth setups measure lung volumes in the intended age group reliably and reproducibly. Characteristics of different techniques should be considered when measuring lung volumes in vivo. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 26, 2014 Category: Respiratory Medicine Authors: Anne Schmidt, Sophie Yammine, Elena Proietti, Urs Frey, Philipp Latzin, Thomas Riedel, Florian Singer Tags: Original Article: Pulmonary Physiology Source Type: research

Effect of Inhaled Endotoxin on Mucociliary Clearance and Airway Inflammation in Mild Smokers and Nonsmokers
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - February 26, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Central role of PAFR signaling in ExoU‐induced NF‐κB activation
Summary ExoU is an important virulence factor in acute Pseudomonas aeruginosa infections. Here, we unveiled the mechanisms of ExoU‐driven NF‐κB activation by using human airway cells and mice infected with P. aeruginosa strains. Luciferase reporter assays showed that PAFR was crucially implicated in the activation of the canonical NF‐κB pathway. Confocal microscopy of lungs from infected mice revealed that PAFR‐dependent NF‐κB activation occurred mainly in respiratory epithelial cells, and reduced p65 nuclear translocation was detected in mice PAFR‐/‐ or treated with the PAFR antagonist WEB 2086. Several e...
Source: Cellular Microbiology - February 26, 2014 Category: Microbiology Authors: Carolina Diettrich Mallet Lima, Jessica Conceição Costa, Sabrina Alves Oliveira Lima Santos, Simone Carvalho, Laís Carvalho, Rodolpho Mattos Albano, Mauro Martins Teixeira, Maria Cristina Maciel Plotkowski, Alessandra Mattos Saliba Tags: Research Article Source Type: research

Issue Information
(Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - February 26, 2014 Category: Infectious Diseases Tags: Issue Information Source Type: research

Feasibility study for early supported discharge in adults with respiratory infection in the UK
Conclusions: An early supported discharge scheme for patients with pneumonia and lower respiratory tract infection was feasible. Larger numbers of patients would be eligible if future work included patients with dementia and those residing in care homes.Trial registration: ISRCTN25542492. (Source: BioMed Central)
Source: BioMed Central - February 26, 2014 Category: Journals (General) Authors: Andrea M CollinsOdiri J EnejeCarole A HancockDaniel G WoottonStephen B Gordon Source Type: research

Correlation of EGFR Mutation Status With Predominant Histologic Subtype of Adenocarcinoma According to the New Lung Adenocarcinoma Classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society.
Conclusion .- Based on the new IASLC/ATS/ERS classification, the predominant subtype of adenocarcinoma was lepidic (44%) in EGFR-mutant lung cancers (P < .001). However, histologic subtype should not be used to exclude patients from tyrosine kinase inhibitor therapy, since EGFR mutations are found in lung adenocarcinomas of other subtypes. PMID: 24571650 [PubMed - as supplied by publisher] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - February 26, 2014 Category: Laboratory Medicine Authors: Villa C, Cagle PT, Johnson M, Patel JD, Yeldandi AV, Raj R, Decamp MM, Raparia K Tags: Arch Pathol Lab Med Source Type: research

An Enzyme-Linked Immunospot Assay for the Detection of Human Respiratory Syncytial Virus F-Specific IFNγ-producing T Cells.
Abstract Respiratory syncytial virus (RSV) causes significant disease in elderly adults and we have previously reported that individuals 65 years of age and older have reduced RSV F-specific interferon gamma (IFNγ)-producing T cells compared to healthy younger adults. To measure RSV F-specific memory T cell responses in the elderly following infection or vaccination, we optimized and qualified an IFNγ enzyme-linked immunospot (ELISPOT) assay. Since peripheral blood mononuclear cells (PBMC) from the elderly could be more fragile, we established optimal cryopreservation techniques and minimal viability acceptance c...
Source: Clinical and Vaccine Immunology - February 26, 2014 Category: Allergy & Immunology Authors: Patton K, Aslam S, Lin J, Yu L, Lambert S, Dawes G, Esser MT, Woo J, Janetzki S, Cherukuri A Tags: Clin Vaccine Immunol Source Type: research

Inhibition of mTORC1 induces loss of E-cadherin through AKT/GSK-3ß signaling-mediated upregulation of E-cadherin repressor complexes in non-small cell lung cancer cells
Conclusions: In conclusion, selective inhibition of mTORC1 leads to hyperactivation of the AKT/GSK-3β pathway, inducing E-cadherin repressor complexes and EMT. These findings imply the existence of a feedback inhibition loop of mTORC1 onto mTORC2 that plays a role in the homeostasis of E-cadherin expression and EMT, requiring caution in the clinical use of rapalog and selective mTORC1 inhibitors. (Source: Respiratory Research)
Source: Respiratory Research - February 26, 2014 Category: Respiratory Medicine Authors: Eun Young KimArum KimSe Kyu KimHyung Jung KimJoon ChangChul Min AhnYoon Soo Chang Source Type: research

Acute suppurative bacterial dacryoadenitis: a rare case report.
Conclusions: Lacrimal gland abscess is a rare clinical entity. To our knowledge, this is the first reported case of Klebsiella pneumoniae-associated dacryoadenitis complicated by lacrimal gland abscess formation in a pediatric patient. PMID: 24585426 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)
Source: European Journal of Ophthalmology - February 26, 2014 Category: Opthalmology Authors: Chandravanshi SL, Mishra V Tags: Eur J Ophthalmol Source Type: research