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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.
Is an Individual Prediction of Maximal Work Rate by 6-Minute Walk Distance and Further Measurements Reliable in Male Patients with Different Lung Diseases
Source: Respiration - January 25, 2013 Category: Respiratory Medicine Source Type: research
Is an Individual Prediction of Maximal Work Rate by 6-Minute Walk Distance and Further Measurements Reliable in Male Patients with Different Lung Diseases?
Source: Respiration - January 25, 2013 Category: Respiratory Medicine Source Type: research
Sleep‐disordered breathing in major depressive disorder
This study examined the rate of sleep‐disordered breathing in depression after excluding those who had clinically significant sleep apnea (>5 apneas∙h−1). Archival data collected between 1991 and 2005 were used to assess the prevalence of sleep‐disordered breathing events in 60 (31 depressed; 29 healthy controls) unmedicated participants. Respiratory events were automatically detected using a program developed in‐house measuring thermal nasal air‐flow and chest pressure. Results show that even after excluding participants with clinically significant sleep‐disordered breathing, individuals with depression c...
Source: Journal of Sleep Research - January 25, 2013 Category: Neurology Authors: Philip Cheng, Melynda D. Casement, Chiau‐Fang Chen, Robert F. Hoffmann, Roseanne Armitage, Patricia J. Deldin Tags: Short Paper Source Type: research
Haemophilus parainfluenzae urethritis among homosexual men.
We report three men who had been having unprotected sex with men (MSM) and subsequently acquired H. parainfluenzae urethritis, which was confirmed by 16S rRNA gene sequencing analysis. Two men were treated with ceftriaxone and doxycycline, and the third man was treated with clarithromycin. All three patients responded to treatment. This case series highlights the potential role of H. parainfluenzae as a sexually transmitted genitourinary pathogen. PMID: 23357607 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - January 25, 2013 Category: Microbiology Authors: Hsu MS, Wu MY, Lin TH, Liao CH Tags: J Microbiol Immunol Infect Source Type: research
Rothia prosthetic knee joint infection.
We describe a 53-year-old female with rheumatoid arthritis complicated by prosthetic knee joint infection due to Rothia species, which was successfully treated by surgical removal of prosthesis and prolonged antimicrobial therapy. The issue of antibiotic prophylaxis before dental procedures among patients with prosthetic joint replacements is discussed. PMID: 23357608 [PubMed - as supplied by publisher]
Source: Journal of Microbiology, Immunology, and Infection - January 25, 2013 Category: Microbiology Authors: Trivedi MN, Malhotra P Tags: J Microbiol Immunol Infect Source Type: research
Martelella endophytica sp. nov., an antifungal bacterium associated with a halophyte.
Abstract A Gram-negative, non-spore forming endophytic bacterium, designated strain YC6887T, was isolated from a root sample of a halophyte, Rosa rugosa collected from a tidal flat area of Namhae Island, located at southern end of Korea. Strain YC6887T was found to exhibit inhibitory activity against oomycete plant pathogens. The cells were non-motile and aerobic rods. The strain was able to grow at 4-40 °C (optimum at 28-30 °C) and at pH 5.0-9.0 (optimum at pH 7.0-8.5). Strain YC6887T was able to grow at NaCl concentrations of 0-9 % (w/v) with optimum growth at 4-5 % (w/v) NaCl, but NaCl is not essential for gro...
Source: International Journal of Systematic and Evolutionary Microbiology - January 25, 2013 Category: Microbiology Authors: Bibi F, Chung EJ, Khan A, Jeon CO, Chung YR Tags: Int J Syst Evol Microbiol Source Type: research
Characteristics of Emergency Pages Using a Computer-Based Anesthesiology Paging System in Children and Adults Undergoing Procedures at a Tertiary Care Medical Center.
CONCLUSION:Emergency pages were rare in patients older than 2 years. Infants were more likely than children 1 to 2 years of age to have emergency page activation, despite both groups being cared for by pediatric fellowship trained anesthesiologists. PMID: 23354339 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - January 25, 2013 Category: Anesthesiology Authors: Weingarten TN, Abenstein JP, Dutton CH, Kohn MA, Lee EA, Mullenbach TE, Narr BJ, Schroeder DR, Sprung J Tags: Anesth Analg Source Type: research
Automatic Identification of Wet and Dry Cough in Pediatric Patients with Respiratory Diseases.
Abstract Cough is the most common symptom of several respiratory diseases. It is a defense mechanism of the body to clear the respiratory tract from foreign materials inhaled accidentally or produced internally by infections. The identification of wet and dry cough is an important clinical finding, aiding in the differential diagnosis especially in children. Wet coughs are more likely to be associated with lower respiratory track bacterial infections. At present during a typical consultation session, the wet/dry decision is based on the subjective judgment of a physician. It is not available for the non-trained per...
Source: Annals of Biomedical Engineering - January 25, 2013 Category: Biomedical Engineering Authors: Swarnkar V, Abeyratne UR, Chang AB, Amrulloh YA, Setyati A, Triasih R Tags: Ann Biomed Eng Source Type: research
Compromised respiratory function in lethal influenza infection is characterized by the depletion of type I alveolar epithelial cells beyond threshold levels.
Abstract During influenza virus infection, it is unclear how much alveolar cell loss can be tolerated before the host succumbs to the disease. We sought to define relevant correlates of disease severity in the mouse influenza model, hypothesizing that a susceptibility threshold exists for alveolar epithelial cell loss. We compared lung pathology, virus spread, alveolar epithelial cell depletion, arterial blood oxygenation, physiological responses measured by unrestrained plethysmography, and oxygen consumption and carbon dioxide production by gas analysis in mice at intervals after infection with virus strains that...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 25, 2013 Category: Cytology Authors: Sanders CJ, Vogel P, McClaren JL, Bajracharya R, Doherty PC, Thomas PG Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Exhaled Breath Condensate Adenosine Tracks Lung Function Changes in Cystic Fibrosis.
Abstract Measurement of exhaled breath condensate (EBC) biomarkers offers a non-invasive means to assess airways disease, but the ability of EBC biomarkers to track longitudinal changes in disease severity remains unproven. EBC was collected from pediatric cystic fibrosis (CF) patients during regular clinic visits over one year. EBC biomarkers urea, adenosine (Ado), and phenylalanine (Phe) were measured by mass spectrometry, and biomarker ratios used to control for variable dilution of airway secretions. EBC biomarker ratios were assessed relative to lung function in longitudinal, multivariate models and compared ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - January 25, 2013 Category: Cytology Authors: Esther CR, Olsen BM, Lin FC, Fine J, Boucher RC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Sleep-disordered breathing in major depressive disorder.
This study examined the rate of sleep-disordered breathing in depression after excluding those who had clinically significant sleep apnea (>5 apneas∙h(-1) ). Archival data collected between 1991 and 2005 were used to assess the prevalence of sleep-disordered breathing events in 60 (31 depressed; 29 healthy controls) unmedicated participants. Respiratory events were automatically detected using a program developed in-house measuring thermal nasal air-flow and chest pressure. Results show that even after excluding participants with clinically significant sleep-disordered breathing, individuals with depression continue t...
Source: Journal of Sleep Research - January 25, 2013 Category: Sleep Medicine Authors: Cheng P, D Casement M, Chen CF, Hoffmann RF, Armitage R, Deldin PJ Tags: J Sleep Res Source Type: research
Distribution and morphology of Clara cells in common marmosets (Callithrix jacchus)
ConclusionsClara cells of common marmosets have species‐specific morphological characteristics, which suggest grouping the common marmoset phenotypically between primates and rodents.
Source: Journal of Medical Primatology - January 25, 2013 Category: Research Authors: Victoria Seidel, Rebecca Hoffmann, Armin Braun, Sophie Seehase, Sascha Knauf, Franz‐Josef Kaup, Martina Bleyer Tags: Original Article Source Type: research
Cigarette smoking is associated with high prevalence of chronic rhinitis and low prevalence of allergic rhinitis in men
ConclusionWe found that smoking was associated with a high prevalence of chronic rhinitis in both sexes and a low prevalence of allergic rhinitis in men. The associations were dose dependent and remained when adjusting for several possible confounders.
Source: Allergy - January 25, 2013 Category: Allergy & Immunology Authors: J. Eriksson, L. Ekerljung, B.‐M. Sundblad, J. Lötvall, K. Torén, E. Rönmark, K. Larsson, B. Lundbäck Tags: Original Article Source Type: research
Influence of Comorbidity on Racial Differences in Receipt of Surgery Among US Veterans With Early-Stage Non-Small-Cell Lung Cancer [Thoracic Oncology]
Conclusion Blacks had a greater prevalence of several comorbid conditions and poor performance status; however, the overall comorbidity score did not differ by race. In general, the effect of comorbidity on receipt of surgery was similar in blacks and whites. Racial differences in comorbidity do not fully explain why blacks undergo lung cancer surgery less often than whites.
Source: Journal of Clinical Oncology - January 25, 2013 Category: Cancer & Oncology Authors: Williams, Stechuchak, Zullig, Provenzale, Kelley Tags: Epidemiology, Surgery Thoracic Oncology Source Type: research
The CBL-interacting protein kinase CIPK26 is a novel interactor of Arabidopsis NADPH oxidase AtRbohF that negatively modulates its ROS-producing activity in a heterologous expression system
The plant NADPH oxidases, known as respiratory burst oxidase homologues (Rbohs), play an indispensable role in a wide array of cellular and developmental processes. Arabidopsis thaliana RbohF (AtRbohF)-mediated production of reactive oxygen species (ROS) is involved in biotic and abiotic stress responses. Because of the toxicity of excess amount of ROS, the ROS-producing activity of Rbohs is speculated to be negatively regulated. However, its mechanism is mostly unknown to date. Here, we report the identification of calcineurin B-like protein-interacting protein kinase 26 (CIPK26) as a novel regulatory factor of AtRbohF. W...
Source: Journal of Biochemistry - January 25, 2013 Category: Biochemistry Authors: Kimura, S., Kawarazaki, T., Nibori, H., Michikawa, M., Imai, A., Kaya, H., Kuchitsu, K. Tags: Regular Papers Source Type: research
Invited Commentary: Use of Arsenical Skin Lesions to Predict Risk of Internal Cancer--Implications for Prevention and Future Research
Arsenic exposure affects millions of people worldwide, causing substantial mortality and morbidity from cancers and cardiovascular and respiratory diseases. An article in the current issue (Am J Epidemiol. 2013;177(3):202–212) reports that classic dermatological manifestations, typically associated with chronic arsenic exposure, are predictive of internal cancers among Taiwanese decades after the cessation of exposure. Specifically, the risk of lung and urothelial cancers was elevated, which was evident regardless of arsenic dose, smoking, and age. There was also an unexpected elevated risk of prostate cancer. Despit...
Source: American Journal of Epidemiology - January 25, 2013 Category: Epidemiology Authors: Ahsan, H., Steinmaus, C. Tags: RESEARCH-ARTICLE Source Type: research
Mesenchymal stem cells promote alveolar epithelial cell wound repair in vitro through distinct migratory and paracrine mechanisms
Conclusion: These findings support the notion for clinical application of hMSCs and/or their secretory factors as a pharmacoregenerative modality for the treatment of idiopathic pulmonary fibrosis (IPF) and other fibrotic lung disorders.
Source: Respiratory Research - January 25, 2013 Category: Respiratory Medicine Authors: Khondoker AkramSohel SamadMonica SpiteriNicholas Forsyth Source Type: research
See correspondence, page 385
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: Olalla Castro‐Añón, Rafael Golpe, Luis A. Pérez‐de‐Llano Tags: CORRESPONDENCE Source Type: research
Non‐invasive mechanical ventilation in obesity hypoventilation syndrome: Are multimodal therapeutic strategies disease essential?
See reply, page 386
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: Antonio M. Esquinas, Angelo Petroianni Tags: CORRESPONDENCE Source Type: research
Diagnosis of silicotuberculosis by Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration (EBUS‐TBNA)
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: ALVIN H. M. TUNG, JENNY C. L. NGAI, FANNY W. S. KO, BETTY P. K. CHAK, LOUIS CHOW, DAVID S‐C. HUI Tags: CLINICAL NOTE Source Type: research
Ambulatory oximetry fails to predict survival in chronic obstructive pulmonary disease with mild‐to‐moderate hypoxaemia
ConclusionsNeither resting PaO2 nor proportion of ambulatory oximetry below 90% saturation effectively predicted survival in COPD.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: JAMES M. TRAUER, CHELSEA A. GIELEN, ALI AMINAZAD, Christopher L. Steinfort Tags: ORIGINAL ARTICLES Source Type: research
Enhanced cytotoxic function of natural killer and natural killer T‐like cells associated with decreased CD94 (Kp43) in the chronic obstructive pulmonary disease airway
Conclusions: Treatment strategies that target NK and NKT‐like cells, their cytotoxicity and production of inflammatory mediators in the airway may improve COPD morbidity.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: GREG HODGE, VIOLET MUKARO, MARK HOLMES, PAUL N. REYNOLDS, SANDRA HODGE Tags: ORIGINAL ARTICLE Source Type: research
Health care‐associated pneumonia in haemodialysis patients: Clinical outcomes in patients treated with narrow versus broad spectrum antibiotic therapy
Conclusions: This study is the first to our knowledge to describe clinical outcomes in patients with haemodialysis as their only HCAP risk factor. Narrow‐spectrum antibiotics may be safe in haemodialysis patients with no other HCAP risk factors. HCAP therapy delayed de‐escalation to oral antibiotics was associated with increased duration of intravenous antibiotics and length of stay.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: STEPHANIE PARKS TAYLOR, BRICE T. TAYLOR Tags: ORIGINAL ARTICLE Source Type: research
Budesonide/formoterol maintenance and reliever therapy via Turbuhaler versus fixed‐dose budesonide/formoterol plus terbutaline in patients with asthma: Phase III study results
ConclusionsBudesonide/formoterol maintenance and reliever therapy provided more effective asthma control, including a prolonged time to first severe asthma exacerbation, than budesonide/formoterol plus terbutaline and was well tolerated. Budesonide/formoterol maintenance and reliever therapy also improved lung function and asthma symptoms.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: TITO ATIENZA, TERESITA AQUINO, MARCELO FERNÁNDEZ, WATCHARA BOONSAWAT, MITSURU KAWAI, TAKAHIDE KUDO, Jan Ekelund, Stefan Ivanov, Lars‐Goran Carlsson Tags: ORIGINAL ARTICLE Source Type: research
Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin‐induced mouse model of asthma
Conclusions: The Sirt1 activator SRT1720 suppressed inflammatory cell infiltration and cytokine production in an OVA‐induced mouse model of asthma. SRT1720 and resveratrol suppressed OVA‐induced splenocyte proliferation and TNF‐α and IL‐6 production. Sirt1 activators might have beneficial effects in asthmatics by suppressing inflammation.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: TOMOMI ICHIKAWA, RYUJI HAYASHI, KENSUKE SUZUKI, SHINGO IMANISHI, KENTA KAMBARA, SEISUKE OKAZAWA, MINEHIKO INOMATA, TORU YAMADA, YU YAMAZAKI, YUKIKO KOSHIMIZU, TOSHIRO MIWA, SHOKO MATSUI, ISAO USUI, MASAHARU URAKAZE, YUJI MATSUYA, MASAKIYO SASAHARA, KAZUYU Tags: ORIGINAL ARTICLE Source Type: research
Invasive pulmonary aspergillosis in non‐neutropenic patients with and without underlying disease: A single‐centre retrospective analysis of 52 subjects
Conclusions: Clinical features of IPA are not well known in non‐neutropenic patients, especially in those without underlying conditions. In this study, organ failure was associated with a lower rate of survival of non‐neutropenic patients with IPA.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: ZHICHU DAI, HAIJIN ZHAO, SHAOXI CAI, YANHUA LV, WANCHENG TONG Tags: ORIGINAL ARTICLE Source Type: research
Prognostic significance of fibroblastic foci in usual interstitial pneumonia and non‐specific interstitial pneumonia
Conclusions: FF correlated with impaired pulmonary function and may be a useful parameter to predict prognosis in patients with UIP and fNSIP.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: TAISHI HARADA, KENTARO WATANABE, KAZUKI NABESHIMA, MAKOTO HAMASAKI, HIROSHI IWASAKI Tags: ORIGINAL ARTICLE Source Type: research
Systemic corticosteroids for community‐acquired pneumonia: Reasons for use and lack of benefit on outcome
ConclusionsThe main reasons for administering systemic steroids were the presence of chronic respiratory comorbidity or severe clinical presentation, but therapy did not influence mortality or clinical stability; by contrast, steroid administration was associated with prolonged length of stay. Nevertheless the steroid group did not show an increased mortality as it was expected according to the initial Pneumonia Severity Index score. Influence of steroids on outcomes of CAP need to be further investigated through randomized clinical trial.
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: EVA POLVERINO, CATIA CILLÓNIZ, POVILAS DAMBRAVA, ALBERT GABARRÚS, MIQUEL FERRER, CARLOS AGUSTÍ, ELENA PRINA, BEATRIZ MONTULL, ROSARIO MENENDEZ, MICHAEL S. NIEDERMAN, ANTONI TORRES Tags: ORIGINAL ARTICLE Source Type: research
Point‐of‐care diagnosis of tuberculosis: Past, present and future
Abstract Diagnosis represents only one aspect of tuberculosis (TB) control but is perhaps one of the most challenging. The drawbacks of current tools highlight several unmet needs in TB diagnosis, that is, necessity for accuracy, rapidity of diagnosis, affordability, simplicity and the ability to generate same‐day results at point‐of‐care (POC). When a return visit is required to access test results, time to treatment is prolonged, and default rates are significant. However, a good diagnostic tool is also critically dependent on obtaining an adequate biological sample. Here, we review the accuracy and potential impac...
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: KEERTAN DHEDA, MORTEN RUHWALD, GRANT THERON, JONATHAN PETER, WING CHEONG YAM Tags: INVITED REVIEW SERIES: TUBERCULOSIS: CURRENT STATE OF KNOWLEDGE Source Type: research
Effect of inhaled corticosteroids on the microbiology of the respiratory tract
See article, page 272
Source: Respirology - January 25, 2013 Category: Respiratory Medicine Authors: Matthew Martin, Dominick Shaw Tags: EDITORIAL Source Type: research
Interactions between autonomic cardiovascular regulation and cortical activity: A CNV study
Abstract The study investigated interactions between autonomic cardiovascular regulation and cortical activity. In 54 healthy subjects, baroreflex sensitivity (BRS) and respiratory sinus arrhythmia (RSA) were assessed at resting conditions. As an EEG indicator of cortical excitability, the contingent negative variation (CNV) was induced using a constant foreperiod reaction time task. At bivariate level, only RSA showed a moderate positive correlation with the CNV recorded at frontal electrodes. However, when common variance of BRS and RSA was controlled for in multiple regression analysis, an inverse association between BR...
Source: Psychophysiology - January 25, 2013 Category: Neurology Authors: Stefan Duschek, Jana Wörsching, Gustavo A. Reyes Del Paso Tags: Original Article Source Type: research
Acute barium intoxication following ingestion of soap water solution
We present a rare case in which a young girl ingested a solution of a hair-removing soap. The ingestion resulted in profound hypokalemia and severe acidosis leading to flaccid paralysis, respiratory arrest and ventricular arrhythmias. Ultimately the patient made complete recovery. The soapwas found to contain barium sulfide. The degree of paralysis and acidosis appeared to be directly related to serum potassium levels.
Source: Indian Journal of Critical Care Medicine - January 25, 2013 Category: Intensive Care Authors: Nandita JoshiChhavi Sarabpreert SharmaSaiJai Prakash Sharma Source Type: research
Overcoming the problem of pseudohypoxemia in myeloproliferative disorders: Another trick in the bag
We report a case of pseudohypoxaemia due to blast crisis in a patient of chronic myeloid leukaemia where arterial blood gas analysed from precooled syringe helped us resolve the problem and hastened our weaning from oxygen therapy.
Source: Indian Journal of Critical Care Medicine - January 25, 2013 Category: Intensive Care Authors: KN PrasadPrabhu ManjunathL PriyaSanjay Sasikumar Source Type: research
Cardiovascular and respiratory effects of the degree of head‐down angle during robot‐assisted laparoscopic radical prostatectomy
ConclusionsThis study demonstrated that the degree of the head‐down angle at RALP affected the cardiovascular and respiratory parameters. Pneumoperitoneum with head‐down position in RALP influenced the cardiovascular and respiratory system to a greater extent than RRP, and these effects were stronger with deeper head‐down angle. Copyright © 2013 John Wiley & Sons, Ltd.
Source: The International Journal of Medical Robotics and Computer Assisted Surgery - January 25, 2013 Category: Surgery Authors: Yoshifumi Kadono, Hiroshi Yaegashi, Kazuaki Machioka, Satoru Ueno, Sotaro Miwa, Yuji Maeda, Tohru Miyagi, Atsushi Mizokami, Yuka Fujii, Tsunehisa Tsubokawa, Ken Yamamoto, Mikio Namiki Tags: Original Article Source Type: research
Severe lower respiratory tract infection in infants and toddlers from a non-affluent population: viral etiology and co-detection as risk factors
Conclusions: Although RSV remains as the main cause of LRTI in infants our study indicates an increase in the length of hospital stay and oxygen use in infants with HRV detected by RT-PCR compared to those without HRV. Moreover, one can speculate that when HRV is detected simultaneously with RSV there is an additive effect that may be reflected in more severe clinical outcome. Also, our study identified a significant number of children infected by recently identified viruses, such as hMPV and Human Bocavirus (HBov), and this is a novel finding for poor communities from developing countries.
Source: BMC Infectious Diseases - January 25, 2013 Category: Infectious Diseases Authors: Emerson da SilvaPaulo PitrezEurico ArrudaRita MattielloEdgar SarriaFlávia de PaulaJosé Proença-ModenaLuana DelcaroOtávio CintraMarcus JonesJosé RibeiroRenato Stein Source Type: research
Phrenic nerve palsy: A rare cause of respiratory distress in newborn
V. S. S. Yerramilli Murty, K Dinedra RamJournal of Pediatric Neurosciences 2012 7(3):225-227Birth injury is defined as an impairment of a newborn's body function or structure due to adverse influences that occurred at birth. Phrenic nerve palsy may result from birth trauma during a traumatic neonatal delivery from a stretch injury due to lateral hyperextension of the neck at birth. This could be a rare cause of respiratory distress in the newborn period with irregular respiration. Respiratory distress due to phrenic nerve damage leading to paralysis of the ipsilateral diaphragm may require continuous positive airway...
Source: Journal of Pediatric Neurosciences - January 25, 2013 Category: Neuroscience Authors: V. S. S. Yerramilli MurtyK Dinedra Ram Source Type: research
Heterogeneity in spinal muscular atrophy with respiratory distress type 1
This report describes a male infant with genetically confirmed SMARD1 presenting with onset of disease in the first two weeks of life with respiratory compromise and urinary retention, which has not been reported before and adds to the phenotypic variability of SMARD 1.
Source: Journal of Pediatric Neurosciences - January 25, 2013 Category: Neuroscience Authors: Aziz MajidKhan TalatLumsden ColinRoss CarolineKingston HelenDe Goede Christian Source Type: research
Mixed miniature postsynaptic currents resulting from co‐release of glycine and GABA recorded from glycinergic neurons in the neonatal respiratory network
Abstract Inhibitory neurons are involved in the generation and patterning of the respiratory rhythm in the adult animal. However, the role of glycinergic neurons in the respiratory rhythm in the developing network is still not understood. Although the complete loss of glycinergic transmission in vivo is lethal, the blockade of glycinergic transmission in slices of the medulla has little effect on pre‐Bötzinger complex network activity. As 50% of the respiratory rhythmic neurons in this slice preparation are glycinergic, they have to be considered as integrated parts of the network. We aimed to investigate whether glycin...
Source: European Journal of Neuroscience - January 25, 2013 Category: Neuroscience Authors: Jamilur Rahman, A. Tobias Latal, Stefanie Besser, Johannes Hirrlinger, Swen Hülsmann Tags: Research Report Source Type: research
Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli
Conclusions: This study demonstrates the efficient conversion of glycerol to L-lactate, a microbial process that had not been reported in the literature prior to our work. The engineered biocatalysts produced L-lactate from crude glycerol in defined minimal salts medium at high chemical and optical purity.
Source: Microbial Cell Factories - January 25, 2013 Category: Microbiology Authors: Suman MazumdarMatthew BlankschienJames ClomburgRamon Gonzalez Source Type: research
Answers to CME questions
Perinatal exposure to nicotine and implications for subsequent obstructive lung disease A 1 True, 2 True, 3 True, 4. False, 5. True
Source: Paediatric Respiratory Reviews - January 24, 2013 Category: Respiratory Medicine Tags: Answers to CME Questions 2012 Source Type: research
Accessible and diverse educational strategies
The art of medicine consists of amusing the patient while nature cures the disease. ∼Voltaire We would like to think much progress has been made over the last 300 years in medicine. These include chest radiographs, antibiotics, computer imaging and of course electronic billing for those in private practice. Beyond the tools of the trade there is the approach to teaching and learning that is so fundamental to medicine. Varying phenotypes of physicians as clinicians and educators have been previously suggested, but clearly these only apply to colleagues working at other institutions. In recognition of the fact that others...
Source: Paediatric Respiratory Reviews - January 24, 2013 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Tags: Main Editorial Source Type: research
High-Dose N-Acetylcysteine in Stable Chronic Obstructive Pulmonary Disease: the 1-Year, Double-Blind, Randomized, Placebo-Controlled HIACE Study.
CONCLUSION: 1-year treatment with high-dose NAC resulted in significantly improved small airways function and decreased exacerbation frequency in patients with stable COPD. CLINICAL TRIAL REGISTRATION: ClinicalTrial.gov ID # NCT01136239. PMID: 23348146 [PubMed - as supplied by publisher]
Source: Chest - January 24, 2013 Category: Respiratory Medicine Authors: Tse HN, Raiteri L, Wong KY, Yee KS, Ng LY, Wai KY, Loo CK, Houng CM Tags: Chest Source Type: research
Toll-like receptor 3 stimulation causes corticosteroid-refractory airway neutrophilia and hyperresponsiveness in mice.
CONCLUSIONS: These results suggest that TLR3 stimulation is involved in corticosteroid refractory airway inflammation in lung, which is enhanced by cigarette smoking, and this may provide a model for understanding virus induced exacerbations in COPD and their therapy. PMID: 23348232 [PubMed - as supplied by publisher]
Source: Chest - January 24, 2013 Category: Respiratory Medicine Authors: Kimura G, Ueda K, Eto S, Watanabe Y, Masuko T, Kusama T, Barnes PJ, Ito K, Kizawa Y Tags: Chest Source Type: research
Comorbid Conditions and Outcomes in Patients With Pulmonary Arterial Hypertension: A REVEAL Registry Analysis.
CONCLUSIONS: Compared with other analyzed comorbidities in PAH patients, hypertension, obesity, diabetes, and COPD were associated with significantly worse 6MWD; obesity and COPD with worse FC; and diabetes and COPD with increased risk of death. Further investigation of the effects of treating these comorbidities in patients with PAH is warranted. CLINICALTRIALS.GOV IDENTIFIER: NCT00370214. PMID: 23348820 [PubMed - as supplied by publisher]
Source: Chest - January 24, 2013 Category: Respiratory Medicine Authors: Poms AM, Turner M, Farber HW, Meltzer LA, McGoon MD Tags: Chest Source Type: research
Airway Vascular Endothelial Function in Healthy Smokers without Systemic Endothelial Dysfunction.
CONCLUSION: Healthy smokers with no signs of systemic inflammation or endothelial dysfunction, display impaired airway vascular endothelial function, possibly preceding systemic endothelial dysfunction. Airway endothelial function was restored with an ICS and the response was directly related to the severity of endothelial dysfunction. PMID: 23348843 [PubMed - as supplied by publisher]
Source: Chest - January 24, 2013 Category: Respiratory Medicine Authors: Mendes ES, Cancado JE, Rebolledo P, Arana J, Parker M, Gonzalez A, Hurwitz BE, Wanner A Tags: Chest Source Type: research