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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.
Multiple alignment comparison of the non-structural genes of three strains of equine influenza viruses (H3N8) isolated in Morocco
Conclusion: It seems that all of these substitutions are not produced at the key residues of the RNA-binding domain (RBD) and the effector domain (ED). Consequently, we can suppose that they will not affect the potency of inhibition of cellular defences, and the virulence of the Moroccan equine strains will be maintained. (Source: BMC Research Notes)
Source: BMC Research Notes - September 24, 2015 Category: Research Authors: Mohamed BoukhartaSouad AzlmatMehdi ElharrakMy Ennaji Source Type: research
Ten-Year Survival in Patients with Idiopathic Pulmonary Fibrosis After Lung Transplantation
Conclusions This study demonstrated a 10-year survival time after LTX in IPF. Furthermore, our study demonstrated a significantly better survival after bilateral LTX in IPF compared to single LTX although bilateral LTX patients were significantly younger. (Source: Lung)
Source: Lung - September 24, 2015 Category: Respiratory Medicine Source Type: research
Safety, tolerability and appropriate use of nintedanib in idiopathic pulmonary fibrosis
Conclusion: Nintedanib had a manageable safety and tolerability profile in patients with IPF. Recommendations for adverse event management minimized permanent treatment discontinuations in the INPULSIS ® trials.Trial registrationclinicaltrials.gov NCT01335464 and NCT01335477 (Source: Respiratory Research)
Source: Respiratory Research - September 24, 2015 Category: Respiratory Medicine Authors: Tamera CorteFrancesco BonellaBruno CrestaniMaurits DemedtsLuca RicheldiCarl CoeckKaty PellingManuel QuaresmaJoseph Lasky Source Type: research
Consequences of Sarcoidosis
Sarcoidosis is a multisystem disorder of unknown cause(s). Less specific disabling symptoms, including fatigue and physical impairments, may have a major influence on the daily activities and the social and professional lives of the patients, resulting in a reduced quality of life. A multidisciplinary approach focusing on somatic and psychosocial aspects is recommended. Patients self-perceived knowledge about the importance of exercise and lifestyle should be improved. Developing the most appropriate therapeutic approach for sarcoidosis requires careful consideration of the possible impact of fatigue, small fiber neuropath...
Source: Clinics in Chest Medicine - September 24, 2015 Category: Respiratory Medicine Authors: Marjolein Drent, Bert Strookappe, Elske Hoitsma, Jolanda De Vries Source Type: research
The skin is the second most common organ affected in sarcoidosis, which can affect patients of all ages and races, with African American women having the highest rates of sarcoidosis in the United States. The cutaneous manifestations are protean and can reflect involvement of sarcoidal granulomas within the lesion or represent reactive non-specific inflammation, as seen with erythema nodosum. Systemic work-up is necessary in any patient with cutaneous involvement of sarcoidal granulomas, and treatment depends on other organ involvement and severity of clinical disease. Skin-directed therapies are first line for mild diseas...
Source: Clinics in Chest Medicine - September 24, 2015 Category: Respiratory Medicine Authors: Karolyn A. Wanat, Misha Rosenbach Source Type: research
Identifying Novel Biomarkers in Sarcoidosis Using Genome-Based Approaches
This article briefly reviews conventional biomarkers used clinically to (1) support a diagnosis and (2) monitor disease progression in patients with sarcoidosis. Potential new biomarkers identified by genome-wide screening and the approaches to discover these biomarkers are described. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - September 24, 2015 Category: Respiratory Medicine Authors: Nancy Casanova, Tong Zhou, Kenneth S. Knox, Joe G.N. Garcia Source Type: research
Pulmonary Complications of Childhood Cancer Treatment
Pulmonary complications of childhood cancer treatment are frequently seen. These can lead to adverse sequelae many years after treatment, with important impact on morbidity, quality of life and mortality in childhood cancer survivors. This review addresses the effects of chemotherapy, radiotherapy, surgery and alloimmunity (in haematopoietic cell transplantation) on the lung in children. It highlights the complexity of lung damage and lung disease in relation to growth and development, infections and other external factors. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - September 24, 2015 Category: Respiratory Medicine Authors: A. Birgitta Versluys, Dorine Bresters Source Type: research
Congenital Heart Disease and Primary Ciliary Dyskinesia
Through the better understanding of the genetics and clinical associations of Primary Ciliary Dyskinesia (PCD), an autosomal recessive disorder of ciliary motility and mucociliary clearance, the association between PCD and heterotaxic congenital heart disease (CHD) has been established. In parallel, research into the cause of CHD has elucidated further the role of ciliary function on the development of normal cardiovascular structure. Increased awareness by clinicians regarding this elevated risk of PCD in patients with CHD will allow for more comprehensive screening and identification of cases in this high-risk group with...
Source: Paediatric Respiratory Reviews - September 24, 2015 Category: Respiratory Medicine Authors: M.J. Harrison, Adam J. Shapiro, Marcus Peter Kennedy Source Type: research
Use of gene sequence clustering to estimate the prevalence of different species among Cystic Fibrosis patients in the UK
We aimed to estimate the prevalence of different Achromobacter species among UK Cystic Fibrosis (CF) patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - September 24, 2015 Category: Respiratory Medicine Authors: Amy Coward, Dervla T.D. Kenna, Claire Perry, Kate Martin, Michel Doumith, Jane F. Turton Tags: Original Article Source Type: research
Renin-associated hypertension after bronchial artery embolization in cystic fibrosis
We report on two cases of multiple renal infarcts and renin-associated hypertension and hypokalemia occurring in CF adults after bronchial artery embolizations. These complications were presumably related to crossing of small calibrated microspheres through arteriovenous anastomoses. Although hypokalemia resolved rapidly, hypertension persisted at least 6 months and its control required multiple antihypertensive agents. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - September 24, 2015 Category: Respiratory Medicine Authors: Nathalie Coolen, Hervé Gouya, Reem Kanaan, Isabelle Honoré, Jeanne Chapron, Dominique Hubert, Paul Legmann, Daniel Dusser, Pierre-Régis Burgel Tags: Case Report Source Type: research
Narrow-band imaging bronchoscopy in the detection of premalignant airway lesions: a meta-analysis of diagnostic test accuracy
Conclusions: Our findings indicate that in the evaluation of premalignant airway lesions, narrow-band imaging has a higher sensitivity, specificity and diagnostic odds ratios compared with autofluorescence imaging bronchoscopy. However, combining autofluorescence imaging bronchoscopy and narrow-band imaging does not significantly improve test performance characteristics. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Iftikhar, I. H., Musani, A. I. Tags: Original Research Source Type: research
Diagnostic yield and safety of sputum induction with nebulized racemic salbutamol versus hypertonic saline in smear-negative pulmonary tuberculosis
Conclusions: SI by nebulized racemic salbutamol solution offers equal benefits to 3% NaCl solution in increasing both sputum quantity and diagnostic yield in smear-negative patients suspected of having pulmonary TB. Nebulized racemic salbutamol does not produce bronchospasm and chest tightness occurs less frequently than with 3% NaCl. Therefore, SI with nebulized racemic salbutamol solution should be considered as a good alternative noninvasive diagnostic tool for the diagnosis of pulmonary TB when hypertonic saline is unavailable or contraindicated. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Keeratichananont, W., Nilmoje, T., Keeratichananont, S., Rittatorn, J. Tags: Original Research Source Type: research
Best practice in the treatment of advanced squamous cell lung cancer
The management of advanced stage nonsmall cell lung cancer (NSCLC) has been altered by the recognition of histology-based treatment and the use of targeted therapy. Whilst outcomes have improved with adenocarcinoma, treatment options are still limited in advanced stage squamous cell lung cancer. With advances in the molecular characterization of squamous cell cancers (SCCs), new potential targets have been identified. In this review, we discuss the role of histology in the treatment of NSCLC, cytotoxic chemotherapy, existing targeted therapies, the new molecular subsets and novel inhibitors in squamous cell lung carcinoma,...
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Ang, Y. L. E., Tan, H.-L., Soo, R. A. Tags: Reviews Source Type: research
The efficacy of ceritinib in patients with ALK-positive non-small cell lung cancer
Research over the last decade has determined that the gene rearrangement involving the anaplastic lymphoma kinase (ALK) gene is an oncogenic driver in approximately 5% of patients with non-small cell lung carcinoma (NSCLC). This review describes the discovery of the ALK translocation, development of ALK directed therapy, and acquired resistance to ALK directed therapy with a focus on the clinical data and efficacy of the most recently approved ALK inhibitor, ceritinib. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Kaczmar, J., Mehra, R. Tags: Reviews Source Type: research
Clinical approaches to treat patients with non-small cell lung cancer and epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance
The discovery of epidermal growth factor receptor activating mutations (EGFR Mut+) has determined a paradigm shift in the treatment of non-small cell lung cancer (NSCLC). In several phase III studies, patients with NSCLC EGFR Mut+ achieved a significantly better progression-free survival when treated with a first- (gefitinib, erlotinib) or second-generation (afatinib) EGFR tyrosine kinase inhibitor (TKI) compared with standard chemotherapy. However, despite these impressive results, most patients with NSCLC EGFR Mut+ develop acquired resistance to TKIs. This review will discuss both the mechanisms of resistance to TKIs and...
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Tartarone, A., Lerose, R. Tags: Reviews Source Type: research
Treatment of emphysema using bronchoscopic lung volume reduction coil technology: an update on efficacy and safety
In the last decade several promising bronchoscopic lung volume reduction (BLVR) treatments were developed and investigated. One of these treatments is BLVR treatment with coils. The advantage of this specific treatment is that it works independently of collateral flow, and also shows promise for patients with a more homogeneous emphysema disease distribution. Seven years ago, the very first patients were treated with BLVR coil treatment and currently large randomized, controlled trials are underway. The aim of this article is to review the available literature and provide an update on the current knowledge on the efficacy ...
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Hartman, J. E., Klooster, K., Ten Hacken, N. H. T., Slebos, D.-J. Tags: Reviews Source Type: research
When a respiratory pathogen turns to the skin: cutaneous tuberculosis in a lung transplant patient
A 62-year-old male, who received immune suppressive therapy due to a lung transplantation several years ago, developed multiple painful abscesses in the right forearm. First misdiagnosed as staphylococcal abscesses, Mycobacterium tuberculosis was eventually cultured from the abscesses. In addition, the patient also suffered from pulmonary tuberculosis and respiratory specimens were also culture-positive for Mycobacterium tuberculosis. Cutaneous tuberculosis must be kept as a differential diagnosis in the case of abscess-like lesions on the skin, especially in immunocompromised patients. Mycobacteria specific tests (polymer...
Source: Therapeutic Advances in Respiratory Disease - September 24, 2015 Category: Respiratory Medicine Authors: Voigtlander, T., Cornberg, M., Gottlieb, J., Welte, T., Suerbaum, S., Bange, F.-C. Tags: Letter to the Editor Source Type: research
Endobronchial ultrasound: beyond nodes and masses
We report a case of massive PE with shock, promptly diagnosed with bed side EBUS – Doppler study, as patient's clinical condition did not allow conventionally proposed diagnostic algorithm. We report a case of massive pulmonary embolism with shock, promptly diagnosed with bed side EBUS – doppler study as patient's clinical condition did not allow conventionally proposed diagnostic algorithm. (Source: Respirology Case Reports)
Source: Respirology Case Reports - September 24, 2015 Category: Respiratory Medicine Authors: Sharad Joshi, Deepak Talwar, Vikas Dogra Tags: Case Report Source Type: research
ECMO‐dependent respiratory failure after snorting speed associated with anti‐GBM antibodies
Abstract A previously well 20‐year‐old man with a history of nasal inhalation of “speed” was retrieved on extracorporeal membrane oxygenation for respiratory failure. Anti‐glomerular basement membrane (anti‐GBM) antibody was positive in the absence of renal disease. We postulate a hitherto unreported causal link between snorting “speed” and lung disease associated with anti‐GBM antibody formation. A previously well 20 year old male with a history of nasal inhalation of “speed” was retrieved on extracorporeal membrane oxygenation for respiratory failure. Antiglomerular basement membrane (anti‐GBM) a...
Source: Respirology Case Reports - September 24, 2015 Category: Respiratory Medicine Authors: Nicholas De Rosa, Allan Glanville Tags: Case Report Source Type: research
Early Respiratory Infections and the Development of Asthma in the First 27 Years of Life
Previous studies have provided contradictory evidence on the role of early childhood respiratory infections in the development of asthma and other allergic diseases during childhood. We investigated early-life respiratory infections as predictors of the development of asthma in a 20-year prospective cohort study (the Espoo Cohort Study, 1991–2011). Information on upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs) was collected with a parent-administered baseline questionnaire covering the preceding 12 months (part 1; n = 2,228), and information on LRTIs leading to hospitalizatio...
Source: American Journal of Epidemiology - September 24, 2015 Category: Epidemiology Authors: Rantala, A. K., Jaakkola, M. S., Makikyro, E. M. S., Hugg, T. T., Jaakkola, J. J. K. Tags: RESEARCH-ARTICLE Source Type: research
Early Characterization of the Severity and Transmissibility of Pandemic Influenza Using Clinical Episode Data from Multiple Populations
This study provides a clear reference in this two-dimensional space against which future novel respiratory pathogens can be rapidly assessed and compared with previous pandemics. (Source: PLoS Computational Biology)
Source: PLoS Computational Biology - September 24, 2015 Category: Biology Authors: Pete Riley et al. Source Type: research
Development of real-time PCR assay for detection of porcine circovirus-like virus P1 in domestic pigs in China
Conclusions: The established qPCR is sensitive, specific, and reliable, which could be a useful tool when applied to quantification of P1 in a variety of samples from infected pigs. (Source: BMC Veterinary Research)
Source: BMC Veterinary Research - September 24, 2015 Category: Veterinary Research Authors: Kong-wang HeLi-bin WenYong-shan WangCheng-ping Lu Source Type: research
Cross-protection against European swine influenza viruses in the context of infection immunity against the 2009 pandemic H1N1 virus: studies in the pig model of influenza
In conclusion, infection with a live, wild type influenza virus may offer substantial cross-lineage protection against viruses of the same HA and/or NA subtype. True heterosubtypic protection, in contrast, appears to be minimal in natural influenza virus hosts. We discuss our findings in the light of the zoonotic and pandemic risks of SIVs. (Source: Veterinary Research)
Source: Veterinary Research - September 24, 2015 Category: Veterinary Research Source Type: research
Comparison of two cytological methods for detecting pulmonary haemorrhage in horses
EXERCISE-INDUCED pulmonary haemorrhage (EIPH) is an important respiratory disease reported to impact racing performance in horses (Hinchcliff and others 2015). Various methods have been described for diagnosing EIPH, including endoscopic detection of tracheal blood after exercise, or cytological evaluation of bronchoalveolar lavage (BAL) fluid. The former is the most frequently used diagnostic method, whereas the latter is reported to be more sensitive (Sullivan and Hinchcliff 2015). Indeed, BAL allows detection of microscopic bleeding and identification of haemosiderophages, that is, alveolar macrophages containing haemos...
Source: Veterinary Record - September 24, 2015 Category: Veterinary Research Authors: Depecker, M., Courouce-Malblanc, A., Leleu, C., Gennevieve, V., Pitel, P. - H., Richard, E. A. Tags: Research Source Type: research
Human bocaviruses: Possible etiologic role in respiratory infectiON
In 2005, Tobias Allander and colleagues  reported that by using a system of genomic virus screening, an unknown human parvovirus was discovered in the respiratory secretions of children with respiratory infection. The newly identified virus shared sequence similarities and genomic organization with the bovine parvovirus and the minute virus of canines , which are two members of the genus bocavirus in the Parvovirinae subfamily of Parvoviridae . Thus, the new agent was named human bocavirus-1 (HBoV1). (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 24, 2015 Category: Virology Authors: Francesco Broccolo, Valeria Falcone, Susanna Esposito, Antonio Toniolo Tags: Review Source Type: research
Response to Letter-to-Editor by M. Tenhunen and S. Himanen: “Assessment of respiratory effort during sleep: esophageal pressure versus noninvasive monitoring techniques”
We thank Ms. Tenhunen and Dr. Himanen for their letter regarding our review article about assessment of respiratory effort during sleep. The authors remark that mattress sensors deserve attention in this review article. They mention that although validation of this technique against esophageal pressure monitoring is limited, some data are available. Kirjavainen et al  examined six volunteers whilst breathing freely, during hypoxia, hypercapnia and inspiratory and expiratory loading. The experiments were performed during the day between 11:00 and 16:00 h, whilst the subjects were awake. (Source: Sleep Medicine Reviews)
Source: Sleep Medicine Reviews - September 24, 2015 Category: Sleep Medicine Authors: Nele L. Vandenbussche, Sebastiaan Overeem, Johannes P. van Dijk, Pieter Jan Simons, Dirk A. Pevernagie Tags: Letter to the editor Source Type: research
Risk of respiratory hospitalization and death, readmission and subsequent mortality: scottish health and ethnicity linkage study
Conclusions: The pattern of ethnic variations in these respiratory disorders was complex and did not merely reflect smoking patterns. Readmission and death after hospitalization data did not signal inequity in services for ethnic minority groups. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - September 24, 2015 Category: Journals (General) Authors: Bhopal, R., Steiner, M. F. C., Cezard, G., Bansal, N., Fischbacher, C., Simpson, C. R., Douglas, A., Sheikh, A., on behalf of the SHELS researchers Tags: Health Source Type: research
Technical Aspects of Endobronchial Ultrasound Guided Transbronchial Needle Aspiration: CHEST Guideline and Expert Panel Report.
Conclusions: Evidence on the technical aspects of EBUS-TBNA varies in strength, but is satisfactory in certain areas to guide clinicians on the best conditions to perform EBUS-guided tissue sampling. Additional research is needed to enhance our knowledge on the optimal performance of this effective procedure. PMID: 26402427 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - September 24, 2015 Category: Respiratory Medicine Authors: Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ Tags: Chest Source Type: research
Pleural hypercarbia after lung surgery is associated with persistent alveolopleural fistulae.
Abstract Background: Persistent air leak (PAL) greater than 5 days due to alveolopleural fistulae is a leading cause of morbidity following surgical resection. Elevated CO2 levels have been reported to inhibit alveolar epithelial proliferation and impair wound healing in vitro. Since the injured lung surface is in direct communication with pleural cavity, we investigated whether pleural gaseous milieu affected lung healing. Methods: O2 and CO2 in pleural gas were determined prospectively in consecutive patients (n=116) undergoing lung resection using infra-red spectroscopy based analyzer. Poisson and logistic r...
Source: Chest - September 24, 2015 Category: Respiratory Medicine Authors: Bharat A, Graf N, Mullen A, Kanter J, Andrei AC, Sporn PH, DeCamp MM, Sznajder JI Tags: Chest Source Type: research
Airway goblet cells secrete pro-inflammatory cytokines, chemokines and growth factors.
Conclusions: Inflammatory mediators released from goblet cells may act in an autocrine and paracrine manner to enhance inflammation, in diseases like asthma where there is increased IL-13 and goblet cell hyperplasia. PMID: 26402158 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - September 24, 2015 Category: Respiratory Medicine Authors: Tanabe T, Rubin BK Tags: Chest Source Type: research
Benefit of Chest Ultrasonography in the Diagnosis of Peripheral Thoracic Lesions in an Interventional Pulmonology Unit.
CONCLUSIONS: Percutaneous ultrasound-guided puncture and biopsy in the diagnosis of peripheral thoracic lesions performed by pulmonologists is a safe procedure with high diagnostic accuracy. We achieved similar results to those previously obtained by radiologists. PMID: 26411258 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - September 24, 2015 Category: Respiratory Medicine Authors: García-Ortega A, Briones-Gómez A, Fabregat S, Martínez-Tomás R, Martínez-García MÁ, Cases E Tags: Arch Bronconeumol Source Type: research
Zooshikella marina sp. nov. a cycloprodigiosin and prodigiosin producing marine bacterium isolated from beach sand.
Abstract A metallic green sheen producing red pigmented bacterium, designated strain JC333T, was isolated from a sample collected from Shivrajpur-Kachigad beach, Gujarat, India. Phylogenetic analyses based on the 16S rRNA gene sequence analysis of strain JC333T showed highest sequence similarity to Zooshikella ganghwensis JC2044T (99.24%) and less than 91.94 % with other members of the class Gammaproteobacteria. DNA-DNA hybridizations between strain JC333T and Zooshikella ganghwensis JC2044T showed low relatedness values of 19±1.3% (reciprocal 21±2.2%). Major respiratory quinone was ubiquinone-9 (Q9) and the po...
Source: International Journal of Systematic and Evolutionary Microbiology - September 24, 2015 Category: Microbiology Authors: E V V R, Dave B, Ch S, Ch V R Tags: Int J Syst Evol Microbiol Source Type: research
The ketogenic diet compensates for AGC1 deficiency and improves myelination
Summary The brain aspartate‐glutamate carrier (AGC1) is specifically expressed in neurons, where it transports aspartate from the mitochondria to the cytosol, and plays a role in transfer of nicotinamide adenine dinucleotide (NADH)‐reducing equivalents into the mitochondria as a part of the malate‐aspartate shuttle. Deficient function of AGC1 underlies an inborn error of metabolism that presents with severe hypotonia, arrested psychomotor development, and seizures from a few months of age. In AGC1 deficiency, there is secondary hypomyelination due to lack of N‐acetylaspartate (NAA), which is normally generated by a...
Source: Epilepsia - September 24, 2015 Category: Neurology Authors: Maria Dahlin, Daniel A. Martin, Zandra Hedlund, Monica Jonsson, Ulrika Döbeln, Anna Wedell Tags: Brief Communication Source Type: research
Pleuro-peritoneal or pericardio-peritoneal leak in children on chronic peritoneal dialysis—A survey from the European Paediatric Dialysis Working Group
Conclusion In conclusion, PPF and PcPF are rare in children on chronic PD, but are associated with significant morbidity, requiring a change of dialysis modality in all cases. Risk factors for PPF development include age of <3 years, herniae and recent abdominal surgery. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - September 23, 2015 Category: Urology & Nephrology Source Type: research
Time for the Global Rollout of Endoscopic Lung Volume Reduction
Chronic obstructive pulmonary disease remains one of the most common causes of morbidity and mortality globally. The disease is generally managed with pharmacotherapy, as well as guidance about smoking cessation and pulmonary rehabilitation. Endoscopic lung volume reduction (ELVR) has been proposed for the treatment of advanced emphysema, with the aim of obtaining the same clinical and functional advantages of surgical lung volume reduction whilst potentially reducing risks and costs. There is a growing body of evidence that certain well-defined sub-groups of patients with advanced emphysema may benefit from ELVR, provided...
Source: Respiration - September 23, 2015 Category: Respiratory Medicine Source Type: research
Efficacy and tolerability of budesonide/formoterol added to tiotropium compared with tiotropium alone in patients with severe or very severe COPD: A randomized, multicentre study in East Asia
ConclusionsIn East Asian patients with severe/very severe COPD, adding budesonide/formoterol to tiotropium was associated with significant improvements in FEV1 and HRQoL and lower COPD exacerbation rates. Treatment was generally well tolerated. Clinical trial registration: NCT01397890 at Clinicaltrials.gov (Source: Respirology)
Source: Respirology - September 23, 2015 Category: Respiratory Medicine Authors: Sang‐Do Lee, Can‐mao Xie, Faisal Yunus, Yohji Itoh, Xia Ling, Wai‐cho Yu, Sumalee Kiatboonsri Tags: Original Article Source Type: research
Tumor suppressor WWOX moderates the mitochondrial respiratory complex
Fragile site FRA16D exhibits DNA instability in cancer, resulting in diminished levels of protein from the WWOX gene that spans it. WWOX suppresses tumor growth by an undefined mechanism. WWOX participates in pathways involving aerobic metabolism and reactive oxygen species. WWOX comprises two WW domains as well as a short‐chain dehydrogenase/reductase enzyme. Herein is described an in vivo genetic analysis in Drosophila melanogaster to identify functional interactions between WWOX and metabolic pathways. Altered WWOX levels modulate variable cellular outgrowths caused by genetic deficiencies of components of the mitocho...
Source: Genes, Chromosomes and Cancer - September 23, 2015 Category: Cancer & Oncology Authors: Amanda Choo, Louise V. O'Keefe, Cheng Shoou Lee, Stephen L. Gregory, Zeeshan Shaukat, Alexander Colella, Kristie Lee, Donna Denton, Robert I. Richards Tags: Research Article Source Type: research
Calculation of the Respiratory Modulation of the Photoplethysmogram (DPOP) Incorporating a Correction for Low Perfusion.
Authors: Addison PS, Wang R, McGonigle SJ, Uribe AA, Bergese SD Abstract DPOP quantifies respiratory modulations in the photoplethysmogram. It has been proposed as a noninvasive surrogate for pulse pressure variation (PPV) used in the prediction of the response to volume expansion in hypovolemic patients. The correlation between DPOP and PPV may degrade due to low perfusion effects. We implemented an automated DPOP algorithm with an optional correction for low perfusion. These two algorithm variants (DPOPa and DPOPb) were tested on data from 20 mechanically ventilated OR patients split into a benign "stable region"...
Source: Anesthesiology Research and Practice - September 23, 2015 Category: Anesthesiology Tags: Anesthesiol Res Pract Source Type: research