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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

[Impact of a psychosocial intervention in caregiver burden of children with cerebral palsy.]
CONCLUSIONS: Problem solving therapy is effective in reducing the burden on caregivers of children with cerebral palsy. PMID: 24581894 [PubMed - as supplied by publisher] (Source: Atencion Primaria)
Source: Atencion Primaria - February 26, 2014 Category: Primary Care Authors: Martínez Lazcano F, Avilés Cura M, Ramírez Aranda JM, Riquelme Heras H, Garza Elizondo T, Barrón Garza F Tags: Aten Primaria Source Type: research

Carbon disulfide induces rat testicular injury via mitochondrial apoptotic pathway.
Abstract Carbon disulfide (CS2), one of the most important volatile organic chemicals, was shown to have serious impairment to male reproductive system. But the underline mechanism is still unclear. In the present study, we aim to investigate the male germ cell apoptosis induced by CS2 exposure alone and by co-administration with cyclosporin A (CsA), which is the inhibitor of membrane permeability transition pore (MPTP). It was shown that CS2 exposure impaired ultrastructure of germ cells, increased the numbers of apoptotic germ cells, accumulated intracellular level of calcium, elevated ROS level, and increased ac...
Source: Chemosphere - February 26, 2014 Category: Chemistry Authors: Guo Y, Wang W, Dong Y, Zhang Z, Zhou Y, Chen G Tags: Chemosphere Source Type: research

Extension of expiration dates for several body system listings. Final rule.
Abstract We are extending the expiration dates of the following body systems in the Listing of Impairments (listings) in our regulations: Growth Impairment, Musculoskeletal System, Respiratory System, Cardiovascular System, Digestive System, Skin Disorders, and Neurological. We are making no other revisions to these body systems in this final rule. This extension will ensure that we continue to have the criteria we need to evaluate impairments in the affected body systems at step three of the sequential evaluation processes for initial claims and continuing disability reviews. PMID: 24611210 [PubMed - in proces...
Source: Fed Regist - February 26, 2014 Category: American Health Authors: Social Security Administration Tags: Fed Regist Source Type: research

Towards coronary plaque imaging using simultaneous PET-MR: a simulation study.
In this study, we proposed and assessed the performance of a fat-MR based coronary motion correction technique for improved FDG-PET coronary plaque imaging in simultaneous PET-MR. The proposed methods were evaluated in a realistic four-dimensional PET-MR simulation study obtained by combining patient water-fat separated MRI and XCAT anthropomorphic phantom. Five small lesions were digitally inserted inside the patients coronary vessels to mimic coronary atherosclerotic plaques. The heart of the XCAT phantom was digitally replaced with the patient's heart. Motion-dependent activity distributions, attenuation maps, and fat-M...
Source: Physics in Medicine and Biology - February 25, 2014 Category: Physics Authors: Petibon Y, El Fakhri G, Nezafat R, Johnson N, Brady T, Ouyang J Tags: Phys Med Biol Source Type: research

Pathophysiological processes in multiple sclerosis: focus on nuclear factor erythroid-2-related factor 2 and emerging pathways
Arnold P, Mojumder D, DeToledo J, Lucius R, Wilms H (Source: International Journal of COPD)
Source: International Journal of COPD - February 25, 2014 Category: Respiratory Medicine Source Type: research

Dendritic cells: Defective antiviral functions in neonatal DCs
Nature Reviews Immunology 14, 139 (2014). doi:10.1038/nri3638 Author: Yvonne Bordon Ruckwardt et al. have compared how adult and neonatal dendritic cells (DCs) respond to respiratory syncytial virus (RSV) infection in mice. They focused on tissue-resident CD103+ and CD11b+ DCs, which capture antigen in the lungs and migrate to the mediastinal (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - February 25, 2014 Category: Allergy & Immunology Authors: Yvonne Bordon Tags: Research Highlight Source Type: research

High‐flow nasal cannula oxygen therapy for infants with bronchiolitis: Pilot study
ConclusionsHFNC treatment in the paediatric ward is safe. Non‐responders requiring PICU admission can be identified within the first hour of HFNC treatment by monitoring HR and RR. It is feasible to undertake a randomised controlled trial based on this pilot with the aim of decreasing PICU admissions. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - February 25, 2014 Category: Pediatrics Authors: Sara Mayfield, Fiona Bogossian, Lee O'Malley, Andreas Schibler Tags: Original Article Source Type: research

Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique
Conclusions: The proportion of pneumonia cases attributable to pneumococcus appeared to be high. Whilst none of the S. pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs. (Source: BMC Research Notes)
Source: BMC Research Notes - February 25, 2014 Category: Research Authors: Jeannet BosSara BeishuizenGeoffrey MadeiraElmano GomondaEsmeralda CossaAugusto MacomeReindert van SteenwijkConstance SchultszJan Prins Source Type: research

Acquired defects in CFTR-dependent Ss-adrenergic sweat secretion in chronic obstructive pulmonary disease
Conclusions: Ss-adrenergic sweat rate was significantly reduced in COPD patients, regardless of smoking status, reflecting acquired CFTR dysfunction and abnormal gland secretion in the skin that can persist despite smoking cessation. Ss-adrenergic sweat rate and sweat chloride are associated with COPD severity and clinical symptoms, supporting the hypothesis that CFTR decrements have a causative role in COPD pathogenesis. (Source: Respiratory Research)
Source: Respiratory Research - February 25, 2014 Category: Respiratory Medicine Authors: Clifford CourvilleSherry TidwellBo LiuFrank AccursoMark DransfieldSteven Rowe Source Type: research

Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD
Conclusion: Although plasma esRAGE is decreased in COPD patients compared to controls, only total sRAGE showed a significant and independent association with FEV1, FEV1/VC and DLCO, indicating that total sRAGE but not esRAGE may serve as marker of COPD disease state and severity. (Source: Respiratory Research)
Source: Respiratory Research - February 25, 2014 Category: Respiratory Medicine Authors: Poornima GopalNiki ReynaertJean ScheijenCasper SchalkwijkFrits FranssenEmiel WoutersErica Rutten Source Type: research

Extreme temperatures and paediatric emergency department admissions
Conclusions As climate change continues, children are at particular risk of a variety of diseases which might be triggered by extremely high temperatures. This study suggests that preventing the effects of extreme temperature on children with respiratory diseases might reduce the number of EDAs. (Source: Journal of Epidemiology and Community Health)
Source: Journal of Epidemiology and Community Health - February 25, 2014 Category: Epidemiology Authors: Xu, Z., Hu, W., Su, H., Turner, L. R., Ye, X., Wang, J., Tong, S. Tags: Air pollution, Environmental issues Research reports Source Type: research

Sleep studies in children on long-term non-invasive respiratory support.
CONCLUSIONS: Titration studies frequently led to recommendations for a change in RS settings in these patients on long-term RS. Symptom scores were more likely to improve if recommendations for change were implemented by the time of the follow-up study. PMID: 24563331 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - February 25, 2014 Category: Sleep Medicine Authors: Widger JA, Davey MJ, Nixon GM Tags: Sleep Breath Source Type: research

Exhaled breath condensate pH decreases during exercise‐induced bronchoconstriction
ConclusionsThe development of EIB was related to acute changes of EBC pH, which suggest the role of airway pH decrease in the pathophysiology of EIB. Exercise‐induced changes in exhaled biomarkers suggest methodological precautions to avoid physical exercise before performing exhaled breath tests. (Source: Respirology)
Source: Respirology - February 25, 2014 Category: Respiratory Medicine Authors: Andras Bikov, Gabriella Galffy, Lilla Tamasi, Dora Bartusek, Balazs Antus, Gyorgy Losonczy, Ildiko Horvath Tags: Original Article Source Type: research

Mutations in RSPH1 Cause Primary Ciliary Dyskinesia with a Unique Clinical and Ciliary Phenotype.
Conclusions: The milder clinical disease and higher nasal nitric oxide in individuals with biallelic mutations in RSPH1 provides evidence of a unique genotype-phenotype relationship in PCD, and suggests that mutations in RSPH1 may be associated with residual ciliary function. Abstract has 250 words. Keywords: cilia, Kartagener, sequencing, mutation, RSPH1. PMID: 24568568 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 25, 2014 Category: Respiratory Medicine Authors: Knowles MR, Ostrowski LE, Leigh MW, Sears PR, Davis SD, Wolf WE, Hazucha MJ, Carson JL, Olivier KN, Sagel SD, Rosenfeld M, Ferkol TW, Dell SD, Milla CE, Randell SH, Yin W, Sannuti A, Metjian HM, Noone PG, Noone PJ, Olson CA, Patrone MV, Dang H, Lee HS, Hu Tags: Am J Respir Crit Care Med Source Type: research

Nogo-B Receptor Modulates Angiogenesis Response of Pulmonary Artery Endothelial Cells Through eNOS Coupling.
Abstract Nogo-B, a Reticulon-4 (RTN4) isoform, modulates the motility and adhesion of vascular endothelial cells after binding to its receptor, NgBR. Nogo-B/NgBR pathway contributes to vascular remodeling and angiogenesis, but the role of this pathway in the angiogenesis of developing lungs remains unknown. We previously reported that angiogenesis function of pulmonary artery endothelial cells (PAEC) is impaired by increased reactive oxygen species (ROS) formation in a fetal lamb model of intrauterine pulmonary hypertension (IPH). Here, we report that Nogo-B/NgBR pathway is altered in IPH and that decreased NgBR ex...
Source: Am J Respir Cell Mol... - February 25, 2014 Category: Respiratory Medicine Authors: Teng RJ, Rana U, Afolayan AJ, Zhao B, Miao QR, Konduri GG Tags: Am J Respir Cell Mol Biol Source Type: research

Performance of a brief asthma control screening tool in community pharmacy: a cross-sectional and prospective longitudinal analysis.
CONCLUSIONS: This study shows that a simple asthma control screening tool is feasible for use in community pharmacies and has good sensitivity for identifying patients with not well-controlled asthma. Screening tools are useful in primary care to identify patients who require more detailed assessment of their asthma status, whereas for monitoring asthma control over time, a continuous control measure is more appropriate. PMID: 24570084 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 25, 2014 Category: Respiratory Medicine Authors: Lemay KS, Armour CL, Reddel HK Tags: Prim Care Respir J Source Type: research

Impact of switching to new spirometric reference equations on severity staging of airflow obstruction in COPD: a crosssectional observational study in primary care.
CONCLUSIONS: Compared with the (corrected) ECSC equations, switching to more contemporary reference equations would result in lower FEV1 predicted values and affect interpretation of spirometry by reclassifying 6-14% of primary care COPD patients into different (mostly milder) severity stages. If and how this will affect GPs' treatment choices in individual patients with COPD requires further investigation. PMID: 24570083 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 25, 2014 Category: Respiratory Medicine Authors: Sluga R, Smeele IJ, Lucas AE, Thoonen BP, Grootens-Stekelenburg JG, Heijdra YF, Schermer TR Tags: Prim Care Respir J Source Type: research

Validation of the COPD Diagnostic Questionnaire in an Australian general practice cohort: a cross-sectional study.
CONCLUSIONS: The CDQ did not discriminate between patients with and without COPD accurately enough to use as a diagnostic tool in patients at increased risk of COPD in Australian general practice. Further research is needed on the value of the CDQ as a tool for selecting patients for spirometry. PMID: 24570082 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 25, 2014 Category: Respiratory Medicine Authors: Stanley AJ, Hasan I, Crockett AJ, van Schayck OC, Zwar NA Tags: Prim Care Respir J Source Type: research

The Global Alliance against Respiratory Diseases (GARD) Country Report.
lan LT, Yusuf O, Akdis C, Baigenzhin A, Cagnani CB, Fletcher M, Gemicioglu B, Muhammed Y, Sagra H, To T, Wagner AH PMID: 24570081 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 25, 2014 Category: Respiratory Medicine Authors: Yorgancioglu A, Cruz AA, Bousquet J, Khaltaev N, Mendis S, Chuchalin A, Bateman ED, Camargos P, Chavannes NH, Bai C, Deleanu D, Kolek V, Kuna P, Laurendi G, Masjedi MR, Mele S, Mihaltan F, Pinto JR, Samolinski B, Scalera G, Sooronbaev T, Tageldin MA, Tuye Tags: Prim Care Respir J Source Type: research

Roseivivax atlanticus sp. nov., isolated from surface seawater of the Atlantic Ocean.
Abstract A taxonomic study was carried out on strain 22II-S10s(T), which was isolated from the surface seawater of the Atlantic Ocean. The bacterium was found to be Gram-negative, oxidase and catalase positive, rod shaped and motile by subpolar flagella. The isolate was capable of gelatine hydrolysis but unable to reduce nitrate to nitrite or degrade Tween 80 or aesculin. Growth was observed at salinities of 0.5-18 % (optimum, 2-12 %), at pH of 3-10 (optimum, 7) and at temperatures of 10-41 °C (optimum 28 °C). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain 22II-S10s(T) belongs to...
Source: Antonie van Leeuwenhoek - February 25, 2014 Category: Microbiology Authors: Li G, Lai Q, Liu X, Sun F, Shao Z Tags: Antonie Van Leeuwenhoek Source Type: research

Antimicrobial susceptibility of Streptococcus pneumoniae in adult patients with pneumococcal pneumonia in an urban hospital in Mozambique
Conclusions: The proportion of pneumonia cases attributable to pneumococcus appeared to be high. Whilst none of the S. pneumoniae strains tested were penicillin resistant, standard penicillin dosing for pneumonia may be insufficient given the observed range of pneumococcal penicillin MICs. (Source: BMC Research Notes)
Source: BMC Research Notes - February 25, 2014 Category: Research Authors: Jeannet BosSara BeishuizenGeoffrey MadeiraElmano GomondaEsmeralda CossaAugusto MacomeReindert van SteenwijkConstance SchultszJan Prins Source Type: research

Antagonism of Substance P and Perception of Breathlessness in Patients with Chronic Obstructive Pulmonary Disease.
The objective of this study was to investigate whether substance P, an excitatory neuropeptide, modulates the perception of breathlessness by administering aprepitant, a selective antagonist that blocks neurokinin (NK)-1 receptor signaling. Individual targeted resistive load breathing (RLB) was used to provoke breathlessness. In Study 1, sixteen patients (age, 70±6 years) with chronic obstructive pulmonary disease (COPD) reported similar ratings of breathlessness during RLB between oral aprepitant (125mg) and placebo. After aprepitant, but not with placebo, there were significant increases in blood levels of substance P (...
Source: Respiratory Care - February 25, 2014 Category: Respiratory Medicine Authors: Mahler DA, Gifford AH, Gilani A, Waterman LA, Hilton J, Chang AS, Kupchak BR, Kraemer WJ Tags: Respir Physiol Neurobiol Source Type: research

Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction.
Abstract Acute Cl2 exposure following industrial accidents or military/terrorist activity causes pulmonary injury and severe acute respiratory distress. Prior studies suggest that antioxidant depletion is important in producing dysfunction, however a pathophysiologic mechanism has not been elucidated. We propose that acute Cl2 inhalation leads to oxidative modification of lung lining fluid, producing surfactant inactivation, inflammation and mechanical respiratory dysfunction at the organ level. C57BL/6J mice underwent whole-body exposure to an effective 60ppm-hour Cl2 dose, and were euthanized 3, 24 and 48h later....
Source: Toxicology and Applied Pharmacology - February 25, 2014 Category: Toxicology Authors: Massa CB, Scott P, Abramova E, Gardner C, Laskin DL, Gow AJ Tags: Toxicol Appl Pharmacol Source Type: research

Inhibition of replication of porcine reproductive and respiratory syndrome virus by hemin is highly dependent on heme oxygenase-1, but independent of iron in MARC-145 cells.
In conclusion, these data demonstrate that hemin had antiviral activity against PRRSV and may serve as useful antiviral agents inhibiting PRRSV replication. PMID: 24583029 [PubMed - as supplied by publisher] (Source: Antiviral Research)
Source: Antiviral Research - February 25, 2014 Category: Virology Authors: Wang L, Xiao S, Gao J, Liu M, Zhang X, Li M, Zhao G, Mo D, Liu X, Chen Y Tags: Antiviral Res Source Type: research

Detection of common respiratory viruses in tonsillar tissue of children with obstructive sleep apnea
ConclusionsRespiratory viruses are detected in OSA hypertrophic tonsils, suggestive of their role in the evolution of tonsillar inflammation and hypertrophy. Early life viral infections may contribute to the pathogenesis of pediatric OSA. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 24, 2014 Category: Respiratory Medicine Authors: Keren Yeshuroon‐Koffler, Yonat Shemer‐Avni, Ayelet Keren‐Naus, Aviv D. Goldbart Tags: Original Article: Sleep & Breathing Source Type: research

[Newsdesk] Research brief
Traditional vaccine development routes have failed to provide effective vaccines for some pathogens. Could epitope-focused vaccine design—the design of immunogens based on structural epitopes defined by protective antibodies isolated from infected patients—succeed? Researchers have used computational protein design to generate small, stable protein scaffolds that mimic the structure of a neutralisation epitope from respiratory syncytial virus (RSV) and that induce potent neutralising antibodies in macaques. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - February 24, 2014 Category: Infectious Diseases Authors: Jane Bradbury Tags: Newsdesk Source Type: research

[Comment] Decrease in antibiotic use, an added benefit of PCVs
Acute respiratory illnesses, especially acute otitis media, are leading causes of antibiotic use in children. However, antibiotic use, either necessary or unnecessary, contributes to the emergence of resistance and is a known risk factor for carriage and spread of resistant bacteria. Several initiatives promoting judicious use of antibiotics have been launched and implemented. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - February 24, 2014 Category: Infectious Diseases Authors: Carlos G Grijalva Tags: Comment Source Type: research

[Comment] Antibiotic prescription for sore throat or the legacy of Mr X2
In his 1945 Nobel lecture, Sir Alexander Fleming described a hypothetical “Mr. X, [who] has a sore throat…buys some penicillin and gives himself, not enough to kill the streptococci but enough to educate them to resist penicillin”. Ironically, this eminent scientist selected group A streptococci for his example—the leading cause of bacterial pharyngitis and almost the sole organism that remains universally susceptible to penicillin in an era of multidrug-resistant bacteria. However, more generally, Fleming was prescient; antibiotic misuse drives antimicrobial resistance and pharyngitis—mainly caused by respirator...
Source: The Lancet Infectious Diseases - February 24, 2014 Category: Infectious Diseases Authors: Benedikt Huttner Tags: Comment Source Type: research

Criteria for designation of clinical substage in canine lymphoma: a survey of veterinary oncologists
Abstract Clinical substage is frequently reported to be prognostic in dogs with lymphoma, yet formal criteria for defining this parameter are lacking. The World Health Organization TNM Classification of Tumors of Domestic Animals simply defines substage as the absence or presence of systemic signs (substages a and b, respectively). We designed a survey to query veterinary oncologists on the criteria they use to determine clinical substage in practice. Gastrointestinal, constitutional and respiratory signs were the most commonly identified clinical factors, with greater than 90% respondents indicating that inappetence, vomi...
Source: Veterinary and Comparative Oncology - February 24, 2014 Category: Veterinary Research Authors: L. G. Barber, K. M. Weishaar Tags: Original Article Source Type: research

Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: a case-control study
Conclusions: Serum 25-OHD measured early after admission to intensive care is not associated with the development of acute lung injury, hospital or one-year mortality in critically ill patients with sepsis although lower 25-OHD levels were associated with higher one-year mortality in patients with severe trauma. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 24, 2014 Category: Epidemiology Authors: Nicolas BarnettZhiguo ZhaoTatsuki KoyamaDavid R JanzChen-Yu WangAddison K MayGordon R BernardLorraine B Ware Source Type: research

Evaluation of respiratory syncytial virus group A and B genotypes among nosocomial and community-acquired pediatric infections in southern Brazil
Conclusions: This is the first study to describe circulation of the NA1 RSV genotype in Brazil. Furthermore, this study showed that the BA4 genotype remains in circulation. Deciphering worldwide RSV genetic variability will aid vaccine design and development. (Source: Virology Journal)
Source: Virology Journal - February 24, 2014 Category: Virology Authors: Fernanda de-ParisCaroline BeckLuciana de Souza NunesAlice MachadoRodrigo PaivaDenise da Silva MenezesMárcia PiresRodrigo dos SantosRicardo de Souza KuchenbeckerAfonso Barth Source Type: research

Viral aetiology influenza like illnesses in Santa Cruz, Bolivia (2010-2012)
Conclusion: Our results emphasise the requirement for a reinforced epidemiological and genetic follow-up of influenza and other ILIs in Bolivia to further inform the preparation of vaccines used in the region, guide vaccination campaigns and improve the medical management of patients. (Source: Virology Journal)
Source: Virology Journal - February 24, 2014 Category: Virology Authors: Julie DelangueYelin Roca SanchezGéraldine PiorkowskiMaël BessaudCécile BarontiLaurence Thirion-PerrierRoxana MafayleCinthia ArdayaGabriela AguileraJimmy GuzmanJavier RieraXavier de Lamballerie Source Type: research

Impact of a short early therapeutic education program on the quality of life of asthmatic children and their families
ConclusionsOur TE program had rapid and beneficial effects on numerous objective and subjective parameters, thereby contributing to the well‐being of the families and probably to a subsequent decrease in the overall cost of asthma management. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 24, 2014 Category: Respiratory Medicine Authors: Valérie Julian, Flore Amat, Isabelle Petit, Bruno Pereira, Jean‐Luc Fauquert, Marie‐Christine Heraud, Guillaume Labbé, André Labbé Tags: Original Article: Asthma Source Type: research

Chloral hydrate sedation for infant pulmonary function testing
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 24, 2014 Category: Respiratory Medicine Authors: Clement L. Ren, Paul Robinson, Sarath Ranganathan Tags: To the Editor Source Type: research

Anemia and iron deficiency in COPD patients: prevalence and the effects of correction of the anemia with erythropoiesis stimulating agents and intravenous iron
Conclusions: ID is common in COPD patients but is rarely looked for or treated. Yet correction of the ID in COPD patients with ESAs and IV iron can improve the anemia, the ID, and may improve the dyspnea. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - February 24, 2014 Category: Respiratory Medicine Authors: Donald SilverbergRam MorMelanie Tia WeuDoron SchwartzIdit SchwartzGil Chernin Source Type: research

Lung density on high resolution computer tomography (HRCT) reflects degree of inflammation in smokers
Conclusions: Lung density on CT is associated with cell concentration in BAL in smokers and may mirror an inflammatory response in the lung. Gender difference in lung density is dependent on height. In COPD with emphysema, loss of lung tissue may counterbalance the expected increase in density due to inflammation. The findings may help to interpret high resolution CT in the context of smoking and gender and highlight the heterogeneity of structural changes in COPD. (Source: Respiratory Research)
Source: Respiratory Research - February 24, 2014 Category: Respiratory Medicine Authors: Reza KarimiGöran TornlingHelena ForsslundMikael MikkoÅsa WheelockSven NyrénC Sköld Source Type: research

Gene–environment interaction in atopic diseases: a population‐based twin study of early‐life exposures
ConclusionIn this population‐based study of children, there was no evidence of genetic effect modification of atopic diseases by several identified early‐life risk factors. The causal relationship between these risk factors and atopic diseases may therefore be mediated via mechanisms different from gene–environment interaction. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 24, 2014 Category: Respiratory Medicine Authors: Niklas Kahr, Vibeke Naeser, Lone Graff Stensballe, Kirsten Ohm Kyvik, Axel Skytthe, Vibeke Backer, Klaus Bønnelykke, Simon Francis Thomsen Tags: Original Article Source Type: research