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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Hydrogen Peroxide Production from Glycerol Metabolism Is Dispensable for Virulence of Mycoplasma gallisepticum in the Tracheas of Chickens [Molecular Pathogenesis]
Hydrogen peroxide (H2O2) is a by-product of glycerol metabolism in mycoplasmas and has been shown to cause cytotoxicity for cocultured eukaryotic cells. There appears to be selective pressure for mycoplasmas to retain the genes needed for glycerol metabolism. This has generated interest and speculation as to their function during infection. However, the actual effects of glycerol metabolism and H2O2 production on virulence in vivo have never been assessed in any Mycoplasma species. To this end, we determined that the wild-type (WT) Rlow strain of the avian pathogen Mycoplasma gallisepticum is capable of producing H2O2 when...
Source: Infection and Immunity - November 10, 2014 Category: Infectious Diseases Authors: Szczepanek, S. M., Boccaccio, M., Pflaum, K., Liao, X., Geary, S. J. Tags: Molecular Pathogenesis Source Type: research

Disease-Associated Neisseria meningitidis Isolates Inhibit Wound Repair in Respiratory Epithelial Cells in a Type IV Pilus-Independent Manner [Cellular Microbiology: Pathogen-Host Cell Molecular Interactions]
Neisseria meningitidis is the causative agent of meningococcal disease. Onset of meningococcal disease can be extremely rapid and can kill within a matter of hours. However, although a much-feared pathogen, Neisseria meningitidis is frequently found in the nasopharyngeal mucosae of healthy carriers. The bacterial factors that distinguish disease- from carriage-associated meningococci are incompletely understood. Evidence suggesting that disruptions to the nasopharynx may increase the risk of acquiring meningococcal disease led us to evaluate the ability of disease- and carriage-associated meningococcal isolates to inhibit ...
Source: Infection and Immunity - November 10, 2014 Category: Infectious Diseases Authors: Ren, X., MacKichan, J. K. Tags: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions Source Type: research

Flavorings in Electronic Cigarettes An Unrecognized Respiratory Health Hazard?
This Viewpoint examines the flavorings added to e-cigarettes and the potential respiratory risks they may pose. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - November 10, 2014 Category: Journals (General) Source Type: research

Current results of endovascular repair of thoraco-abdominal aneurysms [AORTIC SURGERY]
CONCLUSIONS In high-risk patients with TAAA, fenestrated and branch EVAR is associated with low early mortality and requirement for renal support, but the risk of SCI is not insignificant despite the use of cerebrospinal fluid drainage and blood pressure manipulation. Our current practice is to stage the repair of extent I–III aneurysms and this has significantly reduced the incidence of SCI. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - November 10, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Iafrancesco, M., Ranasinghe, A. M., Claridge, M. W., Mascaro, J. G., Adam, D. J. Tags: Pericardium AORTIC SURGERY Source Type: research

Initial experience with routine less invasive implantation of HeartMate II left ventricular assist device without median sternotomy [TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT]
CONCLUSIONS Primary HMII implantation without median sternotomy is feasible and can be safely, effectively and routinely applied, using our less invasive approach. Further investigation is necessary to determine whether the non-invasive technique contributed to the low incidence of bleeding, blood transfusion, respiratory morbidity and right ventricular failure seen in this study. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - November 10, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Anyanwu, A. C., Itagaki, S., Pinney, S., Adams, D. H. Tags: Peripheral vascular, Aorto-iliac disease TRANSPLANTATION AND MECHANICAL CIRCULATORY SUPPORT Source Type: research

The role of the emphysema multidisciplinary team in a successful lung volume reduction surgery programme [THORACIC]
CONCLUSIONS The outcomes of a successful LVRS programme are not only dependent on good surgical technique and post-operative care. Case selection and work-up by a dedicated multidisciplinary approach for emphysema patients plays an invaluable and integral part in an LVRS programme. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - November 10, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Rathinam, S., Oey, I., Steiner, M., Spyt, T., Morgan, M. D., Waller, D. A. Tags: Pleura THORACIC Source Type: research

Belliella kenyensis sp. nov., isolated from the alkaline Lake Elmenteita in the African Rift Valley.
Abstract A red-pigmented, Gram-reaction-negative, aerobic bacterial strain, designated No.164T, was isolated from sediment sample from the alkaline Lake Elmenteita located in the Kenyan Rift Valley. Results of 16S rRNA gene sequence analysis indicated that the isolate belonged to the genus Belliella, with the highest sequence similarity (97%) to Belliella pelovolcani DSM 46698T. Optimal growth temperature was 30-35°C, at pH 7.0-12.0 in the presence of 0-4% (w/v) NaCl. Flexirubins were absent. The respiratory menaquinone (MK-7), predominant cellular fatty acids (iso-C15:0, anteiso-C15:0 and a mixture of C16:1ω7c a...
Source: International Journal of Systematic and Evolutionary Microbiology - November 10, 2014 Category: Microbiology Authors: Akhwale JK, Göker M, Rohde M, Schumann P, Klenk HP, Boga HI Tags: Int J Syst Evol Microbiol Source Type: research

Rhizobium sophorae sp. nov. and Rhizobium sophoriradicis sp. nov., nitrogen-fixing rhizobial symbionts of medicinal legume Sophora flavescens in China.
Abstract Five bacterial strains representing 45 isolates originated from root nodules of the medicinal legume Sophora flavescens were defined as two novel groups in the genus Rhizobium based on their phylogenetic relationships estimated from 16S rRNA genes and the housekeeping genes recA, glnII and atpD. These groups were distantly related to R. leguminosarum USDA 2370T (95.6% similarity for group I) and R. phaseoli ATCC 14482T (93.4% similarity for group II) in the multilocus sequence analysis (MLSA). In DNA-DNA hybridization, the reference strains CCBAU 03386T (group I) and CCBAU 03470T (group II) showed relatedn...
Source: International Journal of Systematic and Evolutionary Microbiology - November 10, 2014 Category: Microbiology Authors: Jiao YS, Yan H, Ji ZJ, Liu YH, Sui XH, Wang ET, Guo BL, Chen WX, Chen WF Tags: Int J Syst Evol Microbiol Source Type: research

Pharmacokinetics, Microbial Response, and Pulmonary Outcomes of Multi-dose Intravenous Azithromycin in Preterm Infants at Risk for Ureaplasma Respiratory Colonization.
Abstract The study objective was to refine the population pharmacokinetics model, determine microbial clearance, and assess short-term pulmonary outcomes of multiple dose azithromycin treatment in preterm infants at risk for Ureaplasma respiratory colon-ization. Fifteen subjects (Ureaplasma-positive=7) received intravenous azithromycin 20 mg/kg every 24h for 3 doses. Azithromycin concentrations were determined in plasma samples obtained up to 168h post-first dose, by a validated LC/MS/MS method. Respiratory samples were obtained pre-dose and at three time points post-last dose for Ureaplasma culture, PCR, antibioti...
Source: Antimicrobial Agents and Chemotherapy - November 10, 2014 Category: Microbiology Authors: Merchan LM, Hassan HE, Terrin ML, Waites KB, Kaufman DA, Ambalavanan N, Donohue P, Dulkerian SJ, Schelonka R, Magder LS, Shukla S, Eddington ND, Viscardi RM Tags: Antimicrob Agents Chemother Source Type: research

Molecular characterization of fluoroquinolone resistance in nontypeable Haemophilus influenzae clinical isolates.
Abstract Nontypeable Haemophilus influenzae (NTHi) is a common cause of respiratory infections in adults, who are frequently treated with fluoroquinolones. The aims of this study were to characterize the genotypes of fluoroquinolone-resistant NTHi isolates and their mechanisms of resistance. Among 7267 H. influenzae isolates collected from adult patients (2000-2013), 28 (0.39%) were ciprofloxacin-resistant according to Clinical and Laboratory Standards Institute (CLSI) criteria. In addition, a nalidixic acid screening during 2010-2013 detected five (0.23%) isolates, which were ciprofloxacin-susceptible but nalidixi...
Source: Antimicrobial Agents and Chemotherapy - November 10, 2014 Category: Microbiology Authors: Puig C, Tirado-Vélez JM, Calatayud L, Tubau F, Garmendia J, Ardanuy C, Marti S, de la Campa AG, Liñares J Tags: Antimicrob Agents Chemother Source Type: research

Pathogen variation across time and space: sequencing to characterize Mannheimia haemolytica diversity.
Abstract Bovine respiratory disease complex (BRDC) is a major animal health and economic issue that affects cattle industries worldwide. Within the USA, the beef cattle industry loses up to an estimated 1 billion dollars a year due to BRDC. There are many contributors to BRDC, including environmental stressors and viral and/or bacterial infections. One species of bacteria in particular, Mannheimia haemolytica, is recognized as the major cause of severe fibrinonecrotic pneumonia in cattle. M. haemolytica is an opportunistic pathogen that normally populates the upper respiratory tract of cattle, and invades the lower...
Source: Animal Health Research Reviews - November 10, 2014 Category: Veterinary Research Authors: Clawson ML, Murray RW Tags: Anim Health Res Rev Source Type: research

The clinical syndrome of BRD: what it is and what it is not.
Abstract The clinical syndrome of bovine respiratory disease (BRD) continues to be a major challenge in bovine production systems. We are challenged by our ability to predict morbidity in groups of cattle, our ability to accurately diagnose and provide a prognosis for individual cases, and our ability to evaluate the results of preventive and therapeutic interventions in the field when production system data are the sole basis for analysis. However, we are fortunate to have perhaps the highest quantity and quality of negative-controlled, prospective, randomized, and masked clinical trial data for any disease in vet...
Source: Animal Health Research Reviews - November 10, 2014 Category: Veterinary Research Authors: Apley M Tags: Anim Health Res Rev Source Type: research

Mild clinical manifestation and unusual recovery upon coenzyme Q10 treatment in the first Chinese Leigh syndrome pedigree with mutation m.10197 G>A.
Mild clinical manifestation and unusual recovery upon coenzyme Q10 treatment in the first Chinese Leigh syndrome pedigree with mutation m.10197 G>A. Mol Med Rep. 2014 Nov 10; Authors: Chen Z, Zhao Z, Ye Q, Chen Y, Pan X, Sun B, Huang H, Zheng A Abstract The Leigh syndrome (LS), characterized by psychomotor retardation, seizures, nystagmus, ophthalmoparesis, optic atrophy, ataxia, dystonia, or respiratory failure, is one of the most severe mitochondrial diseases. In the majority of cases, the disease is fatal and patients die before age 5. Mutation m.10197 G>A was found to relate to the severe phe...
Source: Molecular Medicine - November 10, 2014 Category: Molecular Biology Authors: Chen Z, Zhao Z, Ye Q, Chen Y, Pan X, Sun B, Huang H, Zheng A Tags: Mol Med Rep Source Type: research

Defining inhibitory neurone function in respiratory circuits: Opportunities with optogenetics?
This article is protected by copyright. All rights reserved. PMID: 25384785 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 10, 2014 Category: Physiology Authors: Abdala AP, Paton JF, Smith JC Tags: J Physiol Source Type: research

Facing the challenge of mammalian neural microcircuits: Taking a few breaths may help.
This article is protected by copyright. All rights reserved. PMID: 25384781 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - November 10, 2014 Category: Physiology Authors: Feldman JL, Kam K Tags: J Physiol Source Type: research

Etiologies of Illness among Patients Meeting Integrated Management of Adolescent and Adult Illness District Clinician Manual Criteria for Severe Infections in Northern Tanzania: Implications for Empiric Antimicrobial Therapy.
We describe the laboratory-confirmed etiologies of illness among participants in a hospital-based febrile illness cohort study in northern Tanzania who retrospectively met Integrated Management of Adolescent and Adult Illness District Clinician Manual (IMAI) criteria for septic shock, severe respiratory distress without shock, and severe pneumonia, and compare these etiologies against commonly used antimicrobials, including IMAI recommendations for emergency antibacterials (ceftriaxone or ampicillin plus gentamicin) and IMAI first-line recommendations for severe pneumonia (ceftriaxone and a macrolide). Among 423 participan...
Source: The American Journal of Tropical Medicine and Hygiene - November 10, 2014 Category: Tropical Medicine Authors: Rubach MP, Maro VP, Bartlett JA, Crump JA Tags: Am J Trop Med Hyg Source Type: research

Technical evaluation of a laser-based optical surface scanning system for prospective and retrospective breathing adapted computed tomography.
Abstract Background. For breathing adapted radiotherapy, the same motion monitoring system can be used for imaging and triggering of the accelerator. Purpose. To evaluate a new technique for prospective gated computed tomography (CT) and four-dimensional CT (4DCT) using a laser based surface scanning system (Sentinel(™), C-RAD, Uppsala, Sweden). The system was compared to the AZ-733V respiratory gating system (Anzai Medical, Tokyo, Japan) and the Real-Time Position Management System (RPM(™)) (Varian Medical Systems, Palo Alto, CA, USA). Material and methods. Temporal accuracy was evaluated using a moving phanto...
Source: Acta Oncologica - November 10, 2014 Category: Cancer & Oncology Authors: Jönsson M, Ceberg S, Nordström F, Thornberg C, Bäck SA Tags: Acta Oncol Source Type: research

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis.
CONCLUSIONS: We found that nebulised antibiotics, alone or in combination with oral antibiotics, were better than no treatment for early infection with Pseudomonas aeruginosa. Eradication may be sustained for up to two years. There is insufficient evidence to determine whether antibiotic strategies for the eradication of early Pseudomonas aeruginosa decrease mortality or morbidity, improve quality of life, or are associated with adverse effects compared to placebo or standard treatment. Four trials of two active treatments have failed to show differences in rates of eradication of Pseudomonas aeruginosa. There have been no...
Source: Cochrane Database of Systematic Reviews - November 10, 2014 Category: Journals (General) Authors: Langton Hewer SC, Smyth AR Tags: Cochrane Database Syst Rev Source Type: research

An observational, longitudinal study on the home environment of people with chronic obstructive pulmonary disease: the research protocol of the Home Sweet Home study
Introduction Chronic obstructive pulmonary disease (COPD) represents an important public health challenge. Patients are confronted with limitations during activities of daily living (ADLs). Resident loved ones of patients with COPD may be uniquely positioned to witness these limitations. COPD may have an impact on not only the patients’ life, but also on the lives of the resident loved ones. Furthermore, COPD exacerbation-related hospital admissions often occur in patients with COPD. However, whether and to what extent these admissions influence resident loved ones’ burden and health status remains currently un...
Source: BMJ Open - November 10, 2014 Category: Journals (General) Authors: Nakken, N., Janssen, D. J. A., van den Bogaart, E. H. A., Vercoulen, J. H., Wouters, E. F. M., Spruit, M. A. Tags: Open access, Patient-centred medicine, Respiratory medicine Protocol Source Type: research

Lipidomics applications for discovering biomarkers of diseases in clinical chemistry.
We describe the current status of the identification of metabolic biomarkers in different diseases. We also discuss the lipidomics for the future perspectives and their potential problems. The application of lipidomics in clinical studies may provide new insights into lipid profiling and pathophysiological mechanisms. PMID: 25376488 [PubMed - in process] (Source: International Review of Cell and Molecular Biology)
Source: International Review of Cell and Molecular Biology - November 9, 2014 Category: Cytology Authors: Zhao YY, Cheng XL, Lin RC Tags: Int Rev Cell Mol Biol Source Type: research

Olanzapine plus fluoxetine treatment alters mitochondrial respiratory chain activity in the rat brain.
Authors: Agostinho FR, Réus GZ, Stringari RB, Ribeiro KF, Ferreira GK, Jeremias IC, Scaini G, Rezin GT, Streck EL, Quevedo J PMID: 25380039 [PubMed - as supplied by publisher] (Source: Acta Neuropsychiatrica)
Source: Acta Neuropsychiatrica - November 9, 2014 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

A Novel Method for Assessing Respiratory Deposition of Welding Fume Nanoparticles
(Source: Journal of Occupational and Environmental Hygiene)
Source: Journal of Occupational and Environmental Hygiene - November 9, 2014 Category: Occupational Health Authors: Cena, L. G.Keane, M. J.Chisholm, W. P.Stone, S.Harper, M.Chen, B. T. Source Type: research

JCF — 2014 and beyond
During the past 12months, JCF has continued to grow rapidly in its prominence as a journal publishing important science in the field of cystic fibrosis. Nearing the end of its 13th year, we can celebrate some important achievements. Some of these include: (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - November 9, 2014 Category: Respiratory Medicine Authors: Scott C. Bell, Harry Heijerman, Dominik Hartl Tags: Editorial Source Type: research

News
(Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - November 9, 2014 Category: Respiratory Medicine Source Type: research

Editorial Board
(Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - November 9, 2014 Category: Respiratory Medicine Source Type: research

Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex
Publication date: Available online 28 September 2014 Source:Parasitology International Author(s): Josephine E. Siregar , Genji Kurisu , Tamaki Kobayashi , Motomichi Matsuzaki , Kimitoshi Sakamoto , Fumika Mi-ichi , Yoh-ichi Watanabe , Makoto Hirai , Hiroyuki Matsuoka , Din Syafruddin , Sangkot Marzuki , Kiyoshi Kita Atovaquone, a coenzyme Q analogue has been indicated to specifically target the cytochrome bc 1 complex of the mitochondrial respiratory chain in the malarial parasite and other protozoan. Various mutations in the quinone binding site of the cytochrome b gene of Plasmodium spp. such as M133I, L144S, L271V, K2...
Source: Parasitology International - November 9, 2014 Category: Parasitology Source Type: research

Engineered nanoparticles. How brain friendly is this new guest?
Publication date: August–September 2014 Source:Progress in Neurobiology, Volumes 119–120 Author(s): Francesca A. Cupaioli , Fabio A. Zucca , Diana Boraschi , Luigi Zecca In the last 30 years, the use of engineered nanoparticles (NPs) has progressively increased in many industrial and medical applications. In therapy, NPs may allow more effective cellular and subcellular targeting of drugs. In diagnostic applications, quantum dots are exploited for their optical characteristics, while superparamagnetic iron oxides NPs are used in magnetic resonance imaging. NPs are used in semiconductors, packaging, textiles, solar ce...
Source: Progress in Neurobiology - November 9, 2014 Category: Neuroscience Source Type: research

Acute kidney injury in adults receiving extracorporeal membrane oxygenation
Publication date: November 2014 Source:Journal of the Formosan Medical Association, Volume 113, Issue 11 Author(s): Yung-Chang Chen , Feng-Chun Tsai , Ji-Tseng Fang , Chih-Wei Yang Extracorporeal membrane oxygenation (ECMO) has been utilized for critically ill patients such as patients with postcardiotomy cardiogenic shock or life-threatening respiratory failure. Acute kidney injury (AKI) that develops during ECMO is associated with a very poor outcome, possibly because of accumulated extravascular water causing interstitial overload, impaired oxygen transport through tissues, and increased extravascular lung water volum...
Source: Journal of the Formosan Medical Association - November 9, 2014 Category: Journals (General) Source Type: research

Esophageal lung – A rare bronchopulmonary foregut malformation
We report a case of a 6 month old girl who was previously operated for TEF repair, with esophageal lobe which was successfully excised. The relevant literature is reviewed. (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - November 9, 2014 Category: Surgery Source Type: research

Iatrogenic Diaphragmatic Hernia in Infants: Potentially Catastrophic when Overlooked
We report a case of iatrogenic diaphragmatic hernia in a 6-month old infant presenting with acute respiratory distress as a result of strangulated bowel herniating into the left hemithorax caused from a traumatic chest tube insertion in the neonatal period. (Source: Journal of Pediatric Surgery Case Reports)
Source: Journal of Pediatric Surgery Case Reports - November 9, 2014 Category: Surgery Source Type: research

Evaluation of bioaccessible heavy metal fractions in PM10 from the metropolitan region of Rio de Janeiro city, Brazil, using a simulated lung fluid
Publication date: January 2015 Source:Microchemical Journal, Volume 118 Author(s): Lílian Irene Dias da Silva , Lídia Yokoyama , Lucas Barros Maia , Maria Inês Couto Monteiro , Fernanda Veronesi Marinho Pontes , Manuel Castro Carneiro , Arnaldo Alcover Neto Bioaccessibility studies are important for the estimation of the potential effects on human health caused by metals present in inhalable airborne particulate matter (APM) since their chemical forms determine whether the metals are biologically available. In this work, 24-hPM10 samples from four sampling stations (Bonsucesso, Botafogo, Centro and Nova Iguaçu) of th...
Source: Microchemical Journal - November 9, 2014 Category: Chemistry Source Type: research

Assessment of circulatory and pulmonary endothelin-1 levels in a lavage-induced surfactant-depleted lung injury rabbit model with repeated open endotracheal suctioning and hyperinflation
Publication date: Available online 13 April 2014 Source:Life Sciences Author(s): Junko Kamiyama , Subrina Jesmin , Hideaki Sakuramoto , Nobutake Shimojo , Md. Majedul Islam , Tanzila Khatun , Masami Oki , Satoru Kawano , Taro Mizutani Aims: Endothelin-1 (ET-1) is a mediator of various physiological and pathological processes, including vascular inflammation, cell proliferation and vasoconstriction. Attenuation of ET action using ET-1 antagonists reduces pulmonary vascular leakage and inflammation in several models of lung injuries and experimental acute respiratory distress syndrome (ARDS). Based on these earlier reports...
Source: Life Sciences - November 9, 2014 Category: Biology Source Type: research

Severe flucloxacillin‐induced acute generalized exanthematous pustulosis (AGEP), with toxic epidermal necrolysis (TEN)‐like features: does overlap between AGEP and TEN exist? Clinical report and review of the literature
We present a severe case of AGEP, caused by flucloxacillin, clinically presenting with TEN‐like features and pronounced systemic symptoms with haemodynamic and respiratory instability. Furthermore, we present a review of the literature on cases of AGEP with features resembling SJS/TEN or a supposed overlap with SJS/TEN. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 9, 2014 Category: Dermatology Authors: S. Hattem, G.I. Beerthuizen, S.H. Kardaun Tags: Case Report Source Type: research

Early goal-directed therapy based on endotracheal bioimpedance cardiography: a prospective, randomized controlled study in coronary surgery
The objective was to compare the impact of an early goal-directed hemodynamic therapy based on cardiac output monitoring (Endotracheal Cardiac Output Monitor, ECOM) with a standard of care on postoperative outcome following coronary surgery. This prospective, controlled, parallel-arm trial randomized 100 elective primary coronary artery bypass grafting patients to a study group (ECOM; n = 50) or a control group (control; n = 50). In the ECOM group, hemodynamic therapy was guided by respiratory stroke volume variation and cardiac index given by the ECOM system. A standard of care was used in the control. Goal-directed t...
Source: Journal of Clinical Monitoring and Computing - November 9, 2014 Category: Information Technology Source Type: research

Radiological Characteristics, Histological Features and Clinical Outcomes of Lung Cancer Patients with Coexistent Idiopathic Pulmonary Fibrosis
Conclusions At our centre, 1/20 patients with lung cancer have concomitant IPF. The majority of these tumours are small in size, peripheral in location and squamous cell carcinoma; in an area of honey combing. The outcome for concomitant lung cancer and IPF regardless of stage or therapy is poor. (Source: Lung)
Source: Lung - November 9, 2014 Category: Respiratory Medicine Source Type: research

Mean platelet volume: a novel predictive marker for mortality in intensive care unit (ICU) patients?
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 9, 2014 Category: Respiratory Medicine Authors: Ergenekon Karagöz, Alpaslan Tanoglu Tags: Letter to the Editor Source Type: research

Transbronchial lung biopsy: the pathologist's point of view
ConclusionFCLB method provides larger tissue samples with better quality compared with TBLB. Higher‐quality specimens are associated with less artifact and higher diagnostic yield. Multisite randomized trials are required to improve our knowledge about the benefits and indications of TBLB with cryoprobe. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 9, 2014 Category: Respiratory Medicine Authors: Mihan Pourabdollah, Masoud Shamaei, Shirin Karimi, Mahdi Karimi, Arda Kiani, Hamid Reza Jabbari Tags: Original Article Source Type: research

Outcomes of Pediatric Patients Undergoing Cardiac Catheterization While on Extracorporeal Membrane Oxygenation
Abstract The aim of the study is to explore the indications for cardiac catheterization while on extracorporeal membrane oxygenation (ECMO) and the various catheter interventions performed as well as assess the safety profile and determine the short- and intermediate-term survival. ECMO is a lifesaving intervention for pediatric patients with respiratory and/or cardiovascular failure. There is limited recent literature discussing the survival and outcomes of patients undergoing cardiac catheterization while on ECMO. A retrospective review of consecutive patients undergoing catheterization while on ECMO from 2004...
Source: Mammalian Genome - November 9, 2014 Category: Genetics & Stem Cells Source Type: research

Respiratory sinus arrhythmia stabilizes mean arterial blood pressure at high-frequency interval in healthy humans
Conclusions RSA magnitude is lower and mean arterial blood pressure variability is greater during IPPV than during metronome breathing. We conclude that in healthy humans, RSA stabilizes mean arterial blood pressure at respiratory frequency. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - November 9, 2014 Category: Physiology Source Type: research

Mean platelet volume: a novel predictive marker for mortality in intensive care unit (ICU) patients?
PMID: 25382597 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - November 9, 2014 Category: Respiratory Medicine Authors: Karagöz E, Tanoglu A Tags: Clin Respir J Source Type: research

Retrospective evaluation of CTV to PTV margins using CyberKnife in patients with thoracic tumors
The objectives of this study were to estimate global uncertainty for patients with thoracic tumors treated in our center using the CyberKnife VSI after placement of fiducial markers and to compare our findings with the standard CTV to PTV margins used to date. Datasets for 16 patients (54 fractions) treated with the CyberKnife and the Synchrony Respiratory Tracking System were analyzed retrospectively based on CT planning, tracking information, and movement data generated and saved in the logs files by the system. For each patient, we analyzed all the main uncertainty sources and assigned a value. We also calculated an exp...
Source: Journal of Applied Clinical Medical Physics - November 8, 2014 Category: Physics Source Type: research

Evaluation of dosimetric misrepresentations from 3D conventional planning of liver SBRT using 4D deformable dose integration
The purpose of this study is to evaluate dosimetric errors in 3D conventional plan- ning of stereotactic body radiotherapy (SBRT) by using a 4D deformable image registration (DIR)-based dose-warping and integration technique. Respiratory- correlated 4D CT image sets with 10 phases were acquired for four consecutive patients with five liver tumors. Average intensity projection (AIP) images were used to generate 3D conventional plans of SBRT. Quasi-4D path-integrated dose accumulation was performed over all 10 phases using dose-warping techniques based on DIR. This result was compared to the conventional plan in order to eva...
Source: Journal of Applied Clinical Medical Physics - November 8, 2014 Category: Physics Source Type: research

Anaerobes in biofilm-based healthcare-associated infections.
Abstract Anaerobic bacteria can cause an infection when they encounter a permissive environment within the host. These opportunistic pathogens are seldom recovered as single isolates but more frequently are involved in polymicrobial infections, together with other anaerobes or aerobes. Nowadays it's known that some anaerobic bacteria are also able to grow as biofilm even if this feature and its role in the healthcare-associated infections (HAIs) are still poorly characterized. As consequence, the involvement of biofilm-forming anaerobic bacteria in infections related to healthcare procedures, including surgery and ...
Source: Adv Data - November 8, 2014 Category: Epidemiology Authors: Vuotto C, Donelli G Tags: Adv Exp Med Biol Source Type: research

Mechanisms of carotid body chemoreflex dysfunction during heart failure
This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - November 8, 2014 Category: Physiology Authors: Harold D. Schultz, Noah J. Marcus, Rodrigo Del Rio Tags: Symposium Report Source Type: research

The effects of sex and neonatal stress on PACAP expression
This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - November 8, 2014 Category: Physiology Authors: E.V. Mosca, J.P. Rousseau, R. Gulemetova, R. Kinkead, R.J.A. Wilson Tags: Research Paper Source Type: research

Improved poly(3-hydroxybutyrate) production in Escherichia coli by inactivation of cytochrome bd-II oxidase or/and NDH-II dehydrogenase in low efficient respiratory chains
Publication date: 20 December 2014 Source:Journal of Biotechnology, Volume 192, Part A Author(s): Qiaojie Liu , Zhenquan Lin , Yan Zhang , Yifan Li , Zhiwen Wang , Tao Chen In order to redirect more carbon flux from TCA cycle into poly(3-hydroxybutyrate) (PHB) biosynthesis pathway via increasing respiratory efficiency, appB and ndh genes encoding cytochrome bd-II oxidase and NDH-II dehydrogenase were inactivated in Escherichia coli JM109/pBHR68. All appB or/and ndh knockout strains exhibited significantly increased PHB accumulation accompanying with increased NAD(P)H/NAD(P)+ ratio and intracellular acetyl-CoA pool. Among...
Source: Journal of Biotechnology - November 8, 2014 Category: Biotechnology Source Type: research