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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

COUNTERPOINT: Should Academic Physicians Lecture as Members of Industry Speaker Bureaus? No.
PMID: 25091752 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Nathanson I Tags: Chest Source Type: research

POINT: Should Academic Physicians Lecture as Members of Industry Speaker Bureaus? Yes.
PMID: 25091751 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Greenberg SB, Vender JS Tags: Chest Source Type: research

Lobectomy by VATS: Taking the Plunge.
PMID: 25091750 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Edwards MA, Naunheim KS Tags: Chest Source Type: research

Embrace simplicity when treating lady windermere.
PMID: 25091749 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Jarand J, Field SK Tags: Chest Source Type: research

A new standard of care for critically ill patients with cancer.
PMID: 25091748 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Azoulay E Tags: Chest Source Type: research

Pulmonary arterial hypertension treatment guidelines: new answers and even more questions.
PMID: 25091747 [PubMed - in process] (Source: Chest)
Source: Chest - August 1, 2014 Category: Respiratory Medicine Authors: Hemnes AR Tags: Chest Source Type: research

Venous thromboembolism after diaphragm pacing in amyotrophic lateral sclerosis
Conclusions: These patients highlight the need to consider preoperative screening for DVT and post‐operative thromboprophylaxis in high‐risk ALS patients who undergo DPS placement. © 2014 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - August 1, 2014 Category: Internal Medicine Authors: Kourosh Rezania, Ori Gottlieb, Amy Guralnick, Vivek Prachand, Bobbie J. Sweitzer, Wicki Vigneswaran, Steven R. White, Raymond P. Roos Tags: Case of the Month Source Type: research

Evaluation of antimicrobial treatment in a bovine model of acute Chlamydia psittaci infection: tetracycline versus tetracycline plus rifampicin
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - August 1, 2014 Category: Microbiology Authors: Annette Prohl, Markus Lohr, Carola Ostermann, Elisabeth Liebler‐Tenorio, Angela Berndt, Wieland Schroedl, Michael Rothe, Evelyn Schubert, Konrad Sachse, Petra Reinhold Tags: Research Paper Source Type: research

Cause‐specific mortality by race in low‐income black and white people with Type 2 diabetes
ConclusionsThese findings suggest that the leading causes of death and their risk factors are largely similar among black and white people with diabetes. For the two leading causes of death in each race, however, ischaemic heart disease and respiratory disorders, the magnitude of risk is lower among black people and contributes to their higher survival rates.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)
Source: Diabetic Medicine - August 1, 2014 Category: Endocrinology Authors: B. N. Conway, M. E. May, A. Fischl, J. Frisbee, X. Han, W. J. Blot Tags: Research Article Source Type: research

Dyspnoea and comorbidity contribute to anxiety and depression in interstitial lung disease
ConclusionsAnxiety and depression are present in a significant minority of individuals with ILD. Dyspnoea and comorbidities are important contributors that may be amenable to intervention. (Source: Respirology)
Source: Respirology - August 1, 2014 Category: Respiratory Medicine Authors: Anne E. Holland, Julio F. Fiore, Emily C. Bell, Nicole Goh, Glen Westall, Karen Symons, Leona Dowman, Ian Glaspole Tags: Original Article Source Type: research

Moving stem cell therapy to patients with idiopathic pulmonary fibrosis
(Source: Respirology)
Source: Respirology - August 1, 2014 Category: Respiratory Medicine Authors: Marilyn K. Glassberg, Rebecca L. Toonkel Tags: Editorial Source Type: research

Effect of Kuwanon G Isolated from the Root Bark of Morus alba on Ovalbumin‐induced Allergic Response in a Mouse Model of Asthma
In this study, we investigated the antiasthmatic effect of kuwanon G isolated from MCR on ovalbumin (OVA)‐induced allergic asthma in mice. Kuwanon G (1 and 10 mg/kg) was administered orally in mice once a day for 7 days during OVA airway challenge. We measured the levels of OVA‐specific IgE and Th2 cytokines (IL‐4, IL‐5, and IL‐13) in the sera or bronchoalveolar lavage (BAL) fluids and also counted the immune cells in BAL fluids. Histopathological changes in the lung tissues were analyzed. Kuwanon G significantly decreased the levels of OVA‐specific IgE and IL‐4, IL‐5, and IL‐13 in the sera and BAL fl...
Source: Phytotherapy Research - August 1, 2014 Category: Biochemistry Authors: Hyo Won Jung, Seok Yong Kang, Jong Seong Kang, A Ryun Kim, Eun‐Rhan Woo, Yong‐Ki Park Tags: Research Article Source Type: research

Diagnosis and Treatment of Dynamic Collapse of the Cricotracheal Ligament in Thoroughbred Racehorses
ConclusionsCTLC is a rare cause of dynamic obstruction in Thoroughbred racehorses. Resolution may occur after adaptation to training and after inflammation of the respiratory tract is resolved, but for horses with persistent CTLC, surgical reduction of the cricotracheal space and imbrication of the cricotracheal ligament may result in resolution of clinical signs. (Source: Veterinary Surgery)
Source: Veterinary Surgery - August 1, 2014 Category: Veterinary Research Authors: Padraig G. Kelly, Patrick J. Pollock Tags: Original Article: Clinical Source Type: research

Periorbital oedema after dental extraction: A case study.
Abstract Case study A woman in her early 30s presented with a swollen left eye. She had undergone extraction of an impacted lower left third molar 2 hours earlier. This procedure was done under local anaesthesia and the dentist used a hand-held, high-speed, compressed-air surgical drill to section the tooth before removal. During the procedure, the woman experienced an abnormal sensation that she described as 'a bubble moving up the face'. She also complained of fullness in her left ear, although hearing was unaffected. Clinically, she was haemodynamically stable, apyrexial and was not in respiratory distress. She ...
Source: Australian Family Physician - August 1, 2014 Category: Primary Care Authors: Lim JL Tags: Aust Fam Physician Source Type: research

Trauma intensive care unit 'bouncebacks': identifying risk factors for unexpected return admission to the intensive care unit.
This study assesses the most common events necessitating RT in trauma patients. We performed a retrospective chart review of ICU RT from 2004 to 2008. Patient demographics, injuries and injury severity, reason for transfer, LOS, interventions, and outcomes data were collected. Overall, 158 patients required readmission to the ICU. Respiratory insufficiency/failure (48%) was the most common reason for RT followed by cardiac (16%) and neurological (13%) events. The most commonly associated injuries were traumatic brain injuries (TBIs) (32%), rib fractures (30%), and pulmonary contusions (20%). Initial ICU LOS was 6.6 ± 8 da...
Source: The American Surgeon - August 1, 2014 Category: Surgery Authors: Christmas AB, Freeman E, Chisolm A, Fischer PE, Sachdev G, Jacobs DG, Sing RF Tags: Am Surg Source Type: research

Book Reviews Crash Course Respiratory System (4th edn) Sarah Hickin , James Renshaw , Rachel Williams Mosby 2013 Price £25.99 . Pp 264 ISBN 9780723436270 Essential Revision Notes for Cardiology KBA Edited by Ali Khavandi Oxford University Press 2014 Price £59.99 . Pp 608 ISBN 978 0 19 965490 1 Intelligent Drug Development - Trials and Errors in Clinical Research Michael Tansey OUP USA 2014 Price £29.99 . Pp 240 ISBN 978 0 19 997458 0.
PMID: 25111105 [PubMed - in process] (Source: British Journal of Hospital Medicine)
Source: British Journal of Hospital Medicine - August 1, 2014 Category: Internal Medicine Authors: Scourfield A, Dubrey S, Kapil V Tags: Br J Hosp Med (Lond) Source Type: research

The red blood cell: a new key player in cardiovascular homoeostasis? Focus on the nitric oxide pathway.
Abstract RBCs (red blood cells) have a fundamental role in the regulation of vascular homoeostasis thanks to the ability of these cells to carry O2 (oxygen) between respiratory surfaces and metabolizing tissues and to release vasodilator compounds, such as ATP and NO (nitric oxide), in response to tissue oxygenation. More recently it has been shown that RBCs are also able to produce NO endogenously as they express a functional NOS (nitric oxide synthase), similar to the endothelial isoform. In addition, RBCs carry important enzymes and molecules involved in L-arginine metabolism, such as arginase, NO synthesis inhi...
Source: Biochemical Society Transactions - August 1, 2014 Category: Biochemistry Authors: Porro B, Eligini S, Squellerio I, Tremoli E, Cavalca V Tags: Biochem Soc Trans Source Type: research

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?
Abstract Atherothrombotic disease is a well-recognized complication of diabetes and is a major contributor to the high morbidity and mortality associated with diabetes. Although there is substantial evidence linking diabetes with cardiovascular disease, the specific effect of hyper- (or hypo-) glycaemia is less well understood. The present review focuses on the impact that glycaemic dysregulation has on respiratory function and ROS (reactive oxygen species) generation in the endothelial cells that are critical in preventing several key steps in the atherothrombotic process. Endothelial cells are particularly suscep...
Source: Biochemical Society Transactions - August 1, 2014 Category: Biochemistry Authors: Shaw A, Doherty MK, Mutch NJ, MacRury SM, Megson IL Tags: Biochem Soc Trans Source Type: research

Involvement of NLRP3 inflammasome in rituximab‐induced interstitial lung disease: a case report
We report the first case of rituximab‐induced interstitial lung disease (R‐ILD) with NLRP3 inflammasome activation in the lung. Case summaryA 30‐year‐old male patient diagnosed with idiopathic thrombocytopenic purpura (ITP) was treated with four cycles of rituximab in one month. Three weeks after last rituximab administration, he developed progressive dyspnoea associated with respiratory failure, which was diagnosed as R‐ILD. The patient showed a good response to steroid treatment, and lung biopsy was performed 5 days after the treatment. Immunohistopathological studies of lung specimens showed high expressions ...
Source: Journal of Clinical Pharmacy and Therapeutics - August 1, 2014 Category: Drugs & Pharmacology Authors: H. Kong, Y. Wang, X. Zeng, Q. Zhu, W. Xie, S. Dai Tags: Case Report Source Type: research

Abdominal Fat Suspension Device for Maintaining Normal Cardiorespiratory Function in Patients Undergoing Conscious Sedation during Surgery: A Feasibility Study.
We describe a simple device that might help attenuate this risk. We created a noninvasive suction device for abdominal suspension. By lifting the burden of excess weight, this device should decrease respiratory effort. To test the feasibility of excess weight removal in relieving cardiac stress, we tested 22 supine, healthy, normal-weight subjects by measuring their heart rates with and without a 13-kg tissue model on their abdomen to simulate excess weight. There was no significant difference in blood oxygen saturation before and after weight removal (P=0.318). However, the decrease in heart rate was significant (P <0....
Source: Texas Heart Institute Journal - August 1, 2014 Category: Cardiology Authors: Truong NF, Nathan JC, Yoon D, Ochoa G, Prevost M, Yun S, Oden ZM, Razavi M Tags: Tex Heart Inst J Source Type: research

Early Prophylactic versus Late Selective Use of Surfactant for Respiratory Distress Syndrome in Very Preterm Infants: A Collaborative Study of 53 Multi-Center Trials in Korea.
Abstract Pulmonary surfactant (PS) therapy was proven to be highly successful for the treatment of respiratory distress syndrome in premature infants. As a results, early prophylactic (EP) PS therapy has been introduced recently in Europe, the US and Korea. However, no multi-center study was compared EP and late selective (LS) PS therapies in Korea. We performed a retrospective multi-center study to compare the outcomes of EP and LS PS therapies in very preterm infants. We analyzed clinical morbidity and mortality for 1,291 infants in 2010 (LS group) and 1,249 infants in 2011 (EP group); the infants were born <3...
Source: J Korean Med Sci - August 1, 2014 Category: Journals (General) Authors: Kim SM, Park YJ, Chung SH, Choi YS, Kim CH, Bae CW Tags: J Korean Med Sci Source Type: research

No relationship between mode of delivery and neonatal mortality and neurodevelopment in very low birth weight infants aged two years.
CONCLUSIONS: In neither neurodevelopment nor neonatal mortality did cesarean birth offered significant advantages to VLBW infants. Moreover, the operation might be associated with an increased risk of respiratory distress syndrome for VLBW infants. The mode of delivery of VLBW infants should be largely based on obstetric indications and maternal considerations rather than perceived better outcomes for the neonate. PMID: 25124973 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 1, 2014 Category: Pediatrics Authors: Zhu JJ, Bao YY, Zhang GL, Ma LX, Wu MY Tags: World J Pediatr Source Type: research

The role of surfactant and non-invasive mechanical ventilation in early management of respiratory distress syndrome in premature infants.
CONCLUSION: Not all preterm infants need surfactant treatment, and non-invasive respiratory support is a safe and effective approach. PMID: 25124970 [PubMed - in process] (Source: World Journal of Pediatrics : WJP)
Source: World Journal of Pediatrics : WJP - August 1, 2014 Category: Pediatrics Authors: Iyer NP, Mhanna MJ Tags: World J Pediatr Source Type: research

‘They said it was bronchiolitis; is it going to turn into asthma doctor?’
This article reviews the current state of knowledge regarding the role of acute bronchiolitis in the inception of asthma. There is little doubt that acute bronchiolitis is associated with an increased risk of recurrent wheezing throughout the primary school years although the direction of causality—i.e. whether bronchiolitis in infancy leads to asthma or it merely represents the first clinical presentation of predisposition to asthma—is uncertain. Existing evidence suggests that both host factors (e.g. prematurity, atopic predisposition) and acute viral infection characteristics (e.g. type of virus, severity) are opera...
Source: Respirology - August 1, 2014 Category: Respiratory Medicine Authors: Dimos Gidaris, Don Urquhart, Michael B. Anthracopoulos Tags: Review Source Type: research

Extraction of respiratory myogram interference from the ECG and its application to characterize sleep-related breathing disorders in atrial fibrillation
Present methods to extract respiratory myogram interference (RMI) from the Holter-ECG and assess effect of supraventricular arrhythmias (SVAs) onto ECG-based detection of sleep-related breathing disorders (SRBDs) and AHI estimation. (Source: Journal of Electrocardiology)
Source: Journal of Electrocardiology - August 1, 2014 Category: Cardiology Authors: Christoph Maier, Hartmut Dickhaus Source Type: research

Reduced hypoxic ventilatory response in newborn mice knocked‐out for the progesterone receptor
This article is protected by copyright. All rights reserved (Source: Experimental Physiology)
Source: Experimental Physiology - August 1, 2014 Category: Physiology Authors: Catherine Potvin, Orlane Rossignol, NagaPraveena Uppari, Arnaud Dallongeville, Aida Bairam, Vincent Joseph Tags: Research Paper Source Type: research

The effects of family-friend visits on anxiety, physiological indices and well-being of MI patients admitted to a coronary care unit.
CONCLUSION: Family-friend visits can improve MI patients' sense of well-being and decrease their anxiety. Moreover, the visits can help to keep the physiological indices within normal limits. PMID: 25129882 [PubMed - in process] (Source: Complementary Therapies in Clinical Practice)
Source: Complementary Therapies in Clinical Practice - August 1, 2014 Category: Complementary Medicine Authors: Lolaty HA, Bagheri-Nesami M, Shorofi SA, Golzarodi T, Charati JY Tags: Complement Ther Clin Pract Source Type: research

Feasibility of 8‐OHdG formation and hOGG1 induction in PBMCs for assessing oxidative DNA damage in the lung of COPD patients
ConclusionsCOPD patients manifest oxidative DNA damage of 8‐OHdG along with impaired hOGG1 expression in the lung, whereas 8‐OHdG formation and hOGG1 induction in PBMC could be a biomarker of oxidative DNA damage in the lung. (Source: Respirology)
Source: Respirology - August 1, 2014 Category: Respiratory Medicine Authors: Shifang Yang, Hongxu Wu, Junling Zhao, Xiaojie Wu, Jianping Zhao, Qin Ning, Yongjian Xu, Jungang Xie Tags: Original Article Source Type: research

Phenotype of Matrin 3 related distal myopathy in 16 German patients
Abstract Objective. To characterize the phenotype of patients with distal myopathy with vocal cord and pharyngeal weakness (VCPDM) due to the p.S85C mutation in the Matrin 3 gene (MATR3, MIM 164015). Recently it has been suggested that patients with this mutation may suffer from familial amyotrophic lateral sclerosis. Patients and methods. Sixteen patients from six families with late onset distal myopathy associated with the p.S85C MATR3 mutation were characterized. Results. Patients had a predominantly distal muscle weakness, most severely affecting ankle and wrist dorsiflexion. Relevant proximal and axial weakness was fo...
Source: Annals of Neurology - August 1, 2014 Category: Neurology Authors: T.J. Müller, T Kraya, G Stoltenburg‐Didinger, F Hanisch, M Kornhuber, D Stoevesandt, J Senderek, J Weis, P Baum, M Deschauer, S Zierz Tags: Research Article Source Type: research

Chronic Ethanol Exposure Selectively Inhibits the Influenza‐Specific CD8 T Cell Response During Influenza A Virus Infection
ConclusionsThese findings highlight the previously unrecognized depth of the lesion in the IAV‐specific CD8 T cell response during chronic EtOH consumption. Given the important role CD8 T cell immunity plays in control of IAV, these findings may aid in the development of vaccination and/or therapeutic strategies to reverse these defects in the CD8 T cell response and reduce serious disease outcomes associated with IAV infections in alcoholics. (Source: Alcoholism: Clinical and Experimental Research)
Source: Alcoholism: Clinical and Experimental Research - August 1, 2014 Category: Addiction Authors: Emily A. Hemann, Jodi L. McGill, Kevin L. Legge Tags: Original Article Source Type: research

Characterization of the biochemical-pathway of uranium (VI) reduction in facultative anaerobic bacteria.
Abstract Cultures of U(VI) reducing bacteria sourced from abandoned uranium mine tailing dam were evaluated for their ability to reduce U(VI) to U(IV). The species in the cultures reduced U(VI) in solutions with initial U(VI) concentration up to 400mgL(-)(1) under a near neutral pH of 6.5. The electron flow pathway and fate of reduced species was also analysed in the individual species in order to evaluate the potential for control and optimisation of the reduction potential at the biochemical level. The results showed that U(VI) reduction in live cells was completely blocked by the NADH-dehydrogenase inhibitor, ro...
Source: Chemosphere - July 31, 2014 Category: Chemistry Authors: Mtimunye PJ, Chirwa EM Tags: Chemosphere Source Type: research

Respiratory Cycle-Related Electroencephalographic Changes during Sleep in Healthy Children and in Children with Sleep Disordered Breathing
Conclusion:The presence of nonrandom respiratory cycle-related electroencephalographic changes (RCREC) in both healthy children and in children with sleep disordered breathing (SDB) during NREM and REM sleep has been demonstrated. The RCREC values were higher in children with SDB, predominantly in REM sleep and this difference reduced after adenotonsillectomy.Citation:Immanuel SA, Pamula Y, Kohler M, Martin J, Kennedy D, Saint DA, Baumert M. Respiratory cycle-related electroencephalographic changes during sleep in healthy children and in children with sleep disordered breathing. SLEEP 2014;37(8):1353-1361. (Source: Sleep)
Source: Sleep - July 31, 2014 Category: Sleep Medicine Source Type: research

Management of Sleep Apnea without High Pretest Probability or with Comorbidities by Three Nights of Portable Sleep Monitoring
Conclusions:Three consecutive nights of portable monitoring at home evaluated by a qualified sleep specialist is useful for the management of patients without high pretest probability of obstructive sleep apnea or with comorbidities.Clinical Trial Registration: http://www.clinicaltrials.gov, registration number: NCT01820156 Citation: Guerrero A, Embid C, Isetta V, Farre R, Duran-Cantolla J, Parra O, Barbé F, Montserrat JM, Masa JF. Management of sleep apnea without high pretest probability or with comorbidities by three nights of portable sleep monitoring. SLEEP 2014;37(8):1363-1373. (Source: Sleep)
Source: Sleep - July 31, 2014 Category: Sleep Medicine Source Type: research

Comparative analysis of mucosal immunity to Mycoplasma hyopneumoniae in Jiangquhai porcine lean strain and DLY piglets.
In conclusion, JQHPL pigs exhibits higher resistance to M. hyopneumoniae compared to DLY. It is possible that this characteristic is caused by the faster and stronger mucosal immunity phenotype of the JQHPL strain. PMID: 25061745 [PubMed - in process] (Source: Genetics and Molecular Research)
Source: Genetics and Molecular Research - July 31, 2014 Category: Genetics & Stem Cells Authors: Hua LZ, Wu YZ, Bai FF, William KK, Feng ZX, Liu MJ, Yao JT, Zhang X, Shao GQ Tags: Genet Mol Res Source Type: research

Short-Term Effects of Fine Particulate Air Pollution on Hospital Admissions for Respiratory Diseases: A Case-Crossover Study in a Tropical City
(Source: Journal of Toxicology and Environmental Health Part A)
Source: Journal of Toxicology and Environmental Health Part A - July 31, 2014 Category: Environmental Health Authors: TsaiChiuLiouYang Source Type: research

Mandible behaviour interpretation during wakefulness, sleep and sleep‐disordered breathing
This study aimed to assess (1) the training of independent scorers to recognize the signal specificities; (2) intrascorer reproducibility and (3) interscorer variability. MM was collected in the mid‐sagittal plane of the face of 40 patients. The typical MM was extracted and classified into seven distinct pattern classes: active wakefulness (AW), quiet wakefulness or quiet sleep (QW/S), sleep snoring (SS), sleep obstructive events (OAH), sleep mixed apnea (MA), respiratory related arousal (RERA) and sleep central events (CAH). Four scorers were trained; their diagnostic capacities were assessed on two reading sessions. Th...
Source: Journal of Sleep Research - July 31, 2014 Category: Neurology Authors: Gisèle Maury, Frédéric Senny, Laurent Cambron, Adelin Albert, Laurence Seidel, Robert Poirrier Tags: Regular Research Paper Source Type: research

Autonomic cardiovascular regulation and cortical tone
This study aimed to investigate interactions between tonic cortical arousal and features of autonomic cardiovascular regulation. In 50 healthy subjects, the power spectrum of the spontaneous EEG was obtained at resting state. Concurrently, respiratory sinus arrhythmia (RSA), baroreflex sensitivity (BRS) and R‐wave to pulse interval (RPI) were recorded as indices of cardiovascular control. At the bivariate level, only a negative correlation between beta power recorded at frontal electrode positions and RPI was found. However, when common variance of BRS and RSA was controlled for in multiple regression analyses, a positiv...
Source: Clinical Physiology and Functional Imaging - July 31, 2014 Category: Radiology Authors: Stefan Duschek, Jana Wörsching, Gustavo A. Reyes del Paso Tags: Original Article Source Type: research

AstraZeneca stocks respiratory and cancer pipelines
A $2bn deal with Almirall and a raft of acquisitions and partnership deals bulk up two focus areas for the company (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 31, 2014 Category: Chemistry Authors: Phillip Broadwith Source Type: research

Antibiotic prescribing by telephone in primary care
ConclusionsOverall, one in every eight antibiotics was prescribed via telephone encounter. These data highlight the need to include the impact of this practice in analysis of outcomes associated with outpatient antibiotic prescribing and to incorporate telephonic prescribing into guidelines facilitating appropriate antibiotic use. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 31, 2014 Category: Drugs & Pharmacology Authors: Edward Ewen, Vincent J. Willey, Paul Kolm, William F. McGhan, Marci Drees Tags: Original Report Source Type: research

Association between particulate matter and its chemical constituents of urban air pollution and daily mortality or morbidity in Beijing City.
In this study, we examined the role of particulate matters and its key chemical components of fine particles on both mortality and morbidity in Beijing. We applied several overdispersed Poisson generalized nonlinear models, adjusting for time, day of week, holiday, temperature, and relative humidity, to investigate the association between risk of mortality or morbidity and particulate matters and its constituents in Beijing, China, for January 2005 through December 2009. Particles and several constituents were associated with multiple mortality or morbidity categories, especially on respiratory health. For a 3-day lag, the...
Source: Environmental Science and Pollution Research International - July 31, 2014 Category: Environmental Health Authors: Li P, Xin J, Wang Y, Li G, Pan X, Wang S, Cheng M, Wen T, Wang G, Liu Z Tags: Environ Sci Pollut Res Int Source Type: research

Zinc and Particulate Methane Monooxygenase [Protein Structure and Folding]
Particulate methane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. Zinc is a known inhibitor of pMMO, but the details of zinc binding and the mechanism of inhibition are not understood. Metal binding and activity assays on membrane-bound pMMO from Methylococcus capsulatus (Bath) reveal that zinc inhibits pMMO at two sites that are distinct from the copper active site. The 2.6 Å resolution crystal structure of Methylocystis species strain Rockwell pMMO reveals two previously undetected bound lipids, and metal soaking experiments identify likely locations...
Source: Journal of Biological Chemistry - July 31, 2014 Category: Chemistry Authors: Sirajuddin, S., Barupala, D., Helling, S., Marcus, K., Stemmler, T. L., Rosenzweig, A. C. Tags: Enzymology Source Type: research

CD38 Mediates Angiotensin II-induced Intracellular Ca(2+) Release in Rat Pulmonary Arterial Smooth Muscle Cells.
This study sought to characterize its roles in angiotension II (Ang II)-induced Ca2+ release (AICR) in PASMCs. Examination of CD38 expression in various rat arteries found high levels of CD38 mRNA and protein in pulmonary arteries. Ang II elicited Ca2+ response consisted of extracellular Ca2+ influx and intracellular Ca2+ release in PASMCs. AICR activated in the absence of extracellular Ca2+ was reduced by pharmacological or siRNA inhibition of CD38. It was also reduced by the cADPR-antagonist 8-bromo-cADPR or ryanodine; and by the NAADP-antagonist Ned-19 or disruption of endolysosomal Ca2+ stores with the vacuolar H+-ATPa...
Source: American Journal of Respiratory Cell and Molecular Biology - July 31, 2014 Category: Molecular Biology Authors: Lee S, Paudel O, Jiang Y, Yang XR, Sham JS Tags: Am J Respir Cell Mol Biol Source Type: research

Common Polymorphisms in the CD43 Gene Region Are Associated With Tuberculosis Disease and Mortality.
We examined whether 11 haplotype-tagging SNPs in the CD43 gene region were associated with tuberculous meningitis (TBM) and pulmonary (PTB) tuberculosis in Vietnam. Three SNPs from the CD43 gene region were associated with tuberculosis susceptibility with a genotypic model. The association fit a recessive genetic model and was greater for TBM than PTB (for TBM: rs4788172 (OR 1.64, 95% CI 1.04, 2.59), rs17842268 (OR 2.20, 95% CI 1.29, 3.76), and rs12596308 (OR 2.38, 95% CI 1.47, 3.89). Among TBM cases, rs17842268 was associated with decreased survival (HR=2.7; CI 95% 1.1-6.5; p=0.011). In addition, rs12596308 and rs17842268...
Source: American Journal of Respiratory Cell and Molecular Biology - July 31, 2014 Category: Molecular Biology Authors: Campo M, Randhawa AK, Dunstan S, Farrar J, Caws M, Bang ND, Lan NN, Chau TT, Horne DJ, Thuong NT, Thwaites GE, Hawn TR Tags: Am J Respir Cell Mol Biol Source Type: research

Mandible behaviour interpretation during wakefulness, sleep and sleep-disordered breathing.
This study aimed to assess (1) the training of independent scorers to recognize the signal specificities; (2) intrascorer reproducibility and (3) interscorer variability. MM was collected in the mid-sagittal plane of the face of 40 patients. The typical MM was extracted and classified into seven distinct pattern classes: active wakefulness (AW), quiet wakefulness or quiet sleep (QW/S), sleep snoring (SS), sleep obstructive events (OAH), sleep mixed apnea (MA), respiratory related arousal (RERA) and sleep central events (CAH). Four scorers were trained; their diagnostic capacities were assessed on two reading sessions. The ...
Source: Journal of Sleep Research - July 31, 2014 Category: Sleep Medicine Authors: Maury G, Senny F, Cambron L, Albert A, Seidel L, Poirrier R Tags: J Sleep Res Source Type: research

Biography, pandemic time and risk: Pregnant women reflecting on their experiences of the 2009 influenza pandemic
During the 2009 H1N1 pandemic, it was identified that women in the third trimester of pregnancy were particularly at risk of serious respiratory distress. At-risk women were advised to seek vaccination, avoid contact with anyone unwell, maintain hygiene routines and stop smoking. We examine this situation of emergent and intense risk produced at the intersection of individual biography and the historical event of a public health emergency. We examine how pregnant women took account of risk, how they negotiated incomplete and at times contradictory advice and shaped courses of action that assisted them to manage the emergin...
Source: Health: - July 31, 2014 Category: Global & Universal Authors: Lohm, D., Flowers, P., Stephenson, N., Waller, E., Davis, M. D. Tags: Articles Source Type: research

LL-37 modulates human neutrophil responses to influenza A virus.
In this study, we explore how LL-37 affects interactions of IAV with human neutrophils. LL-37 did not alter neutrophil uptake of IAV but significantly increased neutrophil H2O2 responses to the virus. IAV stimulated production of NETs in vitro, and this response was increased by preincubating the virus with LL-37. NADPH-oxidase blockade did not reduce IAV-induced NET formation or the increased NET response stimulated by LL-37 + IAV. The increased respiratory burst and NET responses were, however, inhibited by preincubating cells with a formyl peptide receptor blocker, indicating that LL-37 engages these receptors when comp...
Source: Journal of Leukocyte Biology - July 31, 2014 Category: Hematology Authors: Tripathi S, Verma A, Kim EJ, White MR, Hartshorn KL Tags: J Leukoc Biol Source Type: research

Coupling of Heart Rate and Systolic Blood Pressure in Hypertensive Pregnancy.
Conclusions: The BSPPA method a) provides improved risk stratification for pregnant women suffering from hypertension and PE, b) increases the ability to diagnose pathological changes, and c) could contribute substantially to the differential diagnosis of hypertensive pregnancy disorders. PMID: 25077755 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Voss A, Fischer C, Schroeder R Tags: Methods Inf Med Source Type: research

Robust Detection of Sleep Apnea from Holter ECGs. Joint Assessment of Modulations in QRS Amplitude and Respiratory Myogram Interference.
Conclusions: Joint occurrence of LF-modulations in QRSA and RMI is a characteristic feature of SRBD that is robustly quantified by the jLSI and permits reliable and reproducible detection of sleep apnea in very heterogeneous settings. PMID: 25077646 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Maier C, Wenz H, Dickhaus H Tags: Methods Inf Med Source Type: research

Modeling and Quantification of Repolarization Feature Dependency on Heart Rate.
Conclusions: In this work an efficient estimation of the parameters of a model aimed at characterizing rate adaptation of repolarization features has been proposed. The Tpe interval has been shown to be rate related and with a shorter memory lag than the QT interval. PMID: 25077546 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Minchole A, Zacur E, Pueyo E, Laguna P Tags: Methods Inf Med Source Type: research