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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Respiratory Syncytial Virus-Associated Hospitalizations in Pre-Mature Infants in Lima, Peru.
Abstract We conducted a prospective cohort study in four hospitals in Lima, Peru in infants with a birth weight ≤ 1,500 g followed from birth hospital discharge up to 1 year of age to determine the incidence of respiratory syncytial virus (RSV) hospitalizations. We enrolled 222 infants from March of 2009 to March of 2010 infants: 48 infants with a birth weight < 1,000 g and 174 infants with a birth weight of 1,000-1,500 g (birth weight = 1,197 ± 224 g; gestational age = 30.1 ± 2.6 weeks). There were 936 episodes of respiratory infections; the incidence of respiratory infections during the first 1 year of lif...
Source: The American Journal of Tropical Medicine and Hygiene - October 6, 2014 Category: Tropical Medicine Authors: Ochoa TJ, Bautista R, Dávila C, Salazar JA, Bazán C, Guerra O, Llanos JP, López L, Zea-Vera A, Ecker L Tags: Am J Trop Med Hyg Source Type: research

Pulmonary rehabilitation for interstitial lung disease.
CONCLUSIONS: Pulmonary rehabilitation seems to be safe for people with ILD. Improvements in functional exercise capacity, dyspnoea and quality of life are seen immediately following pulmonary rehabilitation, with benefits also evident in IPF. Because of inadequate reporting of methods and small numbers of included participants, the quality of evidence was low to moderate. Little evidence was available regarding longer-term effects of pulmonary rehabilitation. PMID: 25284270 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 6, 2014 Category: Journals (General) Authors: Dowman L, Hill CJ, Holland AE Tags: Cochrane Database Syst Rev Source Type: research

[ARAPOC Study: Prevalence of respiratory symptoms and chronic obstructive pulmonary disease in the general population.]
CONCLUSIONS: The high prevalence of COPD and the significant level of underdiagnoses lead to believe that early diagnosis of this disease is still a pending issue. New strategies need to be developed to resolve this problem. PMID: 25300462 [PubMed - as supplied by publisher] (Source: Atencion Primaria)
Source: Atencion Primaria - October 6, 2014 Category: Primary Care Authors: Bruscas Alijarde MJ, Naberan Toña K, Lambán Sánchez MT, Bello Dronda S Tags: Aten Primaria Source Type: research

Sternal tuberculosis: The role of imaging.
PMID: 25301413 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Canella C, Zanetti G, Marchiori E Tags: Arch Bronconeumol Source Type: research

Combination of tracheal bronchus and partial anomalous pulmonary venous return in a patient with type 1 neurofibromatosis and ipsilateral vagal nerve neurofibroma.
PMID: 25301412 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Gorospe Sarasúa L, Saldaña Garrido D, Ayala Carbonero AM Tags: Arch Bronconeumol Source Type: research

Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis.
CONCLUSIONS: PINP and PIIINP are useful markers for severe ILD+SSc, suggesting they could play a role in the follow-up of this complication in SSc. PMID: 25301411 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Gonzalez-Lopez L, Rocha-Muñoz AD, Olivas-Flores EM, Garcia-Gonzalez A, Peguero-Gómez AR, Flores-Navarro J, Villa-Manzano AI, Zavaleta-Muñiz SA, Salazar-Paramo M, Mejía M, Juárez-Contreras P, Vazquez-Del Mercado M, Cardona-Muñoz EG, Trujillo-Hernánd Tags: Arch Bronconeumol Source Type: research

Characteristics of candidates for lung transplantation due to chronic obstructive pulmonary disease and alpha-1 antitrypsin deficiency emphysema.
CONCLUSIONS: The number of patients receiving a lung transplant for COPD has progressively increased and the tendency is to perform the evaluation in earlier stages of the disease. Patients receiving transplants for COPD and AATD had similar characteristics at the time of the evaluation, although AATD patients were younger and had less exposure to tobacco and lower PCO2. PMID: 25301410 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - October 6, 2014 Category: Respiratory Medicine Authors: Giacoboni D, Barrecheguren M, Esquinas C, Rodríguez E, Berastegui C, López-Meseguer M, Monforte V, Bravo C, Pirina P, Miravitlles M, Román A Tags: Arch Bronconeumol Source Type: research

Generation of porcine reproductive and respiratory syndrome virus by in vitro assembly of viral genomic cDNA fragments.
In conclusion, this study describes for the first time the use of GA as a simple, yet powerful tool for generating infectious PRRSV needed for studying PRRSV biology and developing novel vaccines. PMID: 25300804 [PubMed - as supplied by publisher] (Source: Virus Research)
Source: Virus Research - October 6, 2014 Category: Virology Authors: Suhardiman M, Kramyu J, Narkpuk J, Jongkaewwattana A, Wanasen N Tags: Virus Res Source Type: research

strains spreading in Hanoi, Vietnam: Beijing sublineages, genotypes, drug susceptibility patterns, and host factors
Beijing genotype strains are divided into two major sublineages, ancient (atypical) and modern (typical) types, but their phenotypic variations remain largely unknown. Mycobacterium tuberculosis (MTB) isolates from Hanoi, Vietnam, were analyzed by single-nucleotide polymorphisms and spoligotyping. Patient information and drug susceptibility patterns were obtained. Genetic clustering was assessed by variable number of tandem repeat (VNTR) locus sets. Multivariate analysis was also performed to investigate factors possibly associated with these sublineages. (Source: Tuberculosis)
Source: Tuberculosis - October 6, 2014 Category: Respiratory Medicine Authors: Shinji Maeda, Nguyen T.L. Hang, Luu T. Lien, Pham H. Thuong, Nguyen V. Hung, Nguyen P. Hoang, Vu C. Cuong, Minako Hijikata, Shinsaku Sakurada, Naoto Keicho Tags: Epidemiology Source Type: research

Increased percentage of IFNγ-producing CD56 + CD3+ cells in active tuberculosis patients upon CFP-10 stimulation of peripheral mononuclear cells
Aiming to identify a possible biomarker that distinguishes immune cellular response of active tuberculosis from latent infection. Peripheral blood mononuclear cells (PBMCs) of pulmonary tuberculosis (PTB) patients, tuberculin positive household contacts (TST + HHC), and tuberculin negative non-household contacts (TST-NonHHC) were stimulated with PPD or CFP-10 and the percentage of CD69+ cells, proliferating precursor and IFNγ-producing CD4+, CD8+, CD56 + CD3− and CD56 + CD3+ cells were compared. (Source: Tuberculosis)
Source: Tuberculosis - October 6, 2014 Category: Respiratory Medicine Authors: Victoria E. Niño, Luis F. García, Mauricio Rojas, Víctor Campo, Gloria Ávila, Julio Cesar Klínger, Blanca L. Ortiz, María Lilia Díaz Tags: Immunological aspects Source Type: research

Midregional proadrenomedullin for prognosis in community-acquired pneumonia: A systematic review
The initial prognostic assessment of patients with community-acquired pneumonia (CAP) has important clinical implications. We hypothesized that midregional proadrenomedullin (MR-proADM) is a valuable test for the prediction of outcomes in patients with CAP. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 6, 2014 Category: Respiratory Medicine Authors: Rodrigo Cavallazzi, Karim El-Kersh, Emran Abu-Atherah, Sonal Singh, Yoon K. Loke, Timothy Wiemken, Julio Ramirez Tags: Review Source Type: research

Serum and bal beta--glucan for the diagnosis of pneumonia in HIV positive patients
The diagnosis of patients with pulmonary infiltrates and human immunodeficiency virus (HIV) infection remains a challenge. In current clinical practice the gold standard for Pneumocystis jirovecii pneumonia (PCP) diagnosis remains the identification of the organism in bronco alveolar lavage (BAL) using microscopy (e.g., silver stain). (1->3)-β -d-glucan (BG) is a polysaccharide that is present within the cell wall of Pneumocystis and other fungi. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 6, 2014 Category: Respiratory Medicine Authors: D. Salerno, D. Mushatt, L. Myers, Y. Zhuang, N. de la Rua, E.J. Calderon, D.A. Welsh Source Type: research

Association of lung function with coronary heart disease and cardiovascular disease outcomes in elderly: The Rancho Bernardo Study
Lung function is inversely associated with coronary heart disease (CHD) and cardiovascular disease (CVD). We evaluated the prospective association of reduced lung function by spirometry and CHD or CVD events in older community-dwelling adults. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 6, 2014 Category: Respiratory Medicine Authors: Hwa Mu Lee, Michael A. Liu, Elizabeth Barrett-Connor, Nathan D. Wong Source Type: research

Nasal potential difference: Best or average result for function as diagnostic criteria for cystic fibrosis?
The current practice of averaging the nasal potential difference (NPD) results of right and left nostril measurements reduce inter-individual variability but may underestimate individual CFTR function. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 6, 2014 Category: Respiratory Medicine Authors: Katherine Keenan, Julie Avolio, Claudia Rueckes-Nilges, Elizabeth Tullis, Tanja Gonska, Lutz Naehrlich Tags: Original Article Source Type: research

Outbreak of acute respiratory infection in a care home for the vulnerable elderly: investigation, management and challenges
On the afternoon of Friday 2nd April 2012, the West Midlands East Health Protection Team (HPT), based in Birmingham UK, was contacted by a NHS Primary Care Trust (PCT) infection control nurse. Seven deaths due to respiratory illness had occurred since the 13th of March in a 70 bed care home for elderly and end of life patients. The home was contacted and they reported that 18 residents and two members of staff had suffered chest infections since 27th February. (Source: Public Health)
Source: Public Health - October 6, 2014 Category: Global & Universal Authors: A. Mavrodaris, B. Sibal, C. McKerr, J.I. Hawker Tags: Short Communication Source Type: research

Increased percentage of IFN-γ producing CD56CD3 cells in active tuberculosis patients upon CFP-10 stimulation of peripheral mononuclear cells
Aiming to identify a possible biomarker that distinguishes immune cellular response of active tuberculosis from latent infection. Peripheral blood mononuclear cells (PBMCs) of pulmonary tuberculosis patients (PTB), tuberculin positive household contacts (TST+ HHC), and tuberculin negative non-household contacts (TST− Non HHC) were stimulated with PPD or CFP-10 and the percentage of CD69+ cells, proliferating precursor and IFN-γ producing CD4+, CD8+, CD56+CD3− and CD56+CD3+ cells were compared. IL-2, IL-12p70, IL-15, IL-18 and IL-10 were measured in culture supernatants. (Source: Tuberculosis)
Source: Tuberculosis - October 6, 2014 Category: Respiratory Medicine Authors: Victoria E. Niño, Luis F. García, Mauricio Rojas, Víctor Campo, Gloria Ávila, Julio Cesar Klínger, Blanca L. Ortiz, María Lilia Díaz Tags: Immunological aspects Source Type: research

Adult-Onset Recurrent Respiratory Papillomatosis May Be Associated with Number of Sexual Partners
What risk factors, if any, are strongly associated with adult-onset recurrent respiratory papillomatosis (AO-RRP)? (Source: ENT Today)
Source: ENT Today - October 5, 2014 Category: ENT & OMF Authors: Amy Eckner Tags: Laryngology Literature Reviews Practice Focus HPV Source Type: research

Protein and microRNA biomarkers from lavage, urine, and serum in military personnel evaluated for dyspnea
Conclusions: Candidate proteins and miRNAs associated with the general diagnosis of dyspnea have been identified in subjects with differing medical diagnoses. Since these markers can be measured in readily obtained clinical samples, further studies are possible that test the value of these findings in more formal classification or case-control studies in much larger cohorts of subjects with specific lung diseases such as asthma, emphysema, or some other well-defined lung disease. (Source: BMC Medical Genomics)
Source: BMC Medical Genomics - October 5, 2014 Category: Genetics & Stem Cells Authors: Joseph BrownHeather BrewerCarrie NicoraKarl WeitzMichael MorrisAndrew SkabelundJoshua AdkinsRichard SmithJi-Hoon ChoRichard Gelinas Source Type: research

Anticholinergics/Antimuscarinic Drugs in Asthma
Abstract Anticholinergic alkaloids have been used for thousands of years for the relief of bronchoconstriction and other respiratory symptoms, and their use in the treatment of chronic obstructive pulmonary disease is well established. Acetylcholine, acting through muscarinic receptor (M) receptor, modulates multiple physiologic functions pertinent to asthma including airway muscle tone, mucus gland secretion, and various parameters of inflammation and remodeling. In addition, activation of M receptors may inhibit beta2 adrenoreceptor. These observations offer the rationale for the use of M receptors antagonists ...
Source: Current Allergy and Asthma Reports - October 5, 2014 Category: Allergy & Immunology Source Type: research

Validation method to determine metals in atmospheric particulate matter by inductively coupled plasma optical emission spectrometry
Atmospheric particulate matter (PM) is a pollutant composed by various metals, that when accumulated in the respiratory system may cause serious health problems. Methods IO-3.1 (metal extraction in PM) and IO-3.4 [metal determination by inductively coupled plasma optical emission spectrometry (ICP-OES)] are the recommended by the United State Environmental Protection Agency. With the intent to evaluate the performance of the method developed in our laboratory for the extraction of metal in PM with HNO3 p.a. bidistilled and determination by ICP-OES of Al, Ca, Cd, Cu, Cr, Fe, K, Mg, Mn, Na, Ni, Pb, Ti, V and Zn, validation w...
Source: Journal of the Brazilian Chemical Society - October 4, 2014 Category: Chemistry Source Type: research

[World Report] Rare enterovirus continues to circulate in North America
D68, an uncommon strain of enterovirus, has caused an unexpectedly high number of respiratory illnesses across the USA and has now appeared in Canada. Brian Owens reports. (Source: LANCET)
Source: LANCET - October 4, 2014 Category: Journals (General) Authors: Brian Owens Tags: World Report Source Type: research

TargetCOPD: a pragmatic randomised controlled trial of targeted case finding for COPD versus routine practice in primary care: protocol
In this study, using a cluster randomised controlled trial (RCT) in 56 general practices in the West Midlands, we plan to investigate the effectiveness and cost-effectiveness of a Targeted approach to case finding for COPD compared with routine practice. Using an individual patient RCT nested in the Targeted arm, we plan also to compare the effectiveness and cost-effectiveness of Active case finding using a postal questionnaire (with supplementary opportunistic questionnaires), and Opportunistic-only case finding during routine surgery consultations.All ever-smoking patients aged 40-79 years, without a current diagnosis of...
Source: BioMed Central - October 4, 2014 Category: Journals (General) Authors: Rachel E JordanPeymane AdabSue JowettJen MarshRichard RileyAlexandra EnocsonMartin MillerBrendan CooperAlice TurnerJon G AyresKar Keung ChengKate JollyRobert StockleySheila GreenfieldStanley SiebertAmanda DaleyDavid Fitzmaurice Source Type: research

Indacaterol improves lung hyperinflation and physical activity in patients with moderate chronic obstructive pulmonary disease - a randomized, multicenter, double-blind, placebo-controlled study
Conclusions: Indacaterol 150 mug improved lung hyperinflation in patients with moderate COPD, which was associated with an increase of physical activity.Trial registration: ClinicalTrials.gov registration number: NCT01012765. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - October 4, 2014 Category: Respiratory Medicine Authors: Henrik WatzFelix KrippnerAnne KirstenHelgo MagnussenClaus Vogelmeier Source Type: research

Intestinal current measurement versus nasal potential difference measurements for diagnosis of cystic fibrosis: a case-control study
Background: Nasal potential difference (NPD) and intestinal current measurement (ICM) are functional CFTR tests that are used as adjunctive diagnostic tools for cystic fibrosis (CF). Smoking has a systemic negative impact on CFTR function. A diagnostic comparison between NPD and ICM and the impact of smoking on both CFTR tests has not been done. Methods: The sweat chloride test, NPD, and ICM were performed in 18 patients with CF (sweat chloride >60 mmol/l), including 6 pancreatic sufficient (PS) patients, and 13 healthy controls, including 8 smokers. The NPD CFTR response to Cl-free and isoproterenol perfusion (Delta0Cl- +...
Source: BMC Pulmonary Medicine - Latest articles - October 4, 2014 Category: Respiratory Medicine Authors: Azadeh Bagheri-HansonSebastian NedwedClaudia Rueckes-NilgesLutz Naehrlich Source Type: research

The use of non‐invasive ventilation in very old patients with hypercapnic acute respiratory failure because of COPD exacerbation
ConclusionsThe use of NIV in very old patients was effective in many cases. Endotracheal intubation after NIV failure was not efficacious in either group. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - October 4, 2014 Category: Internal Medicine Authors: A. Nicolini, M. Santo, L. Ferrera, M. Ferrari‐Bravo, C. Barlascini, A. Perazzo Tags: Original Paper Source Type: research

Systematic identification of transcriptional and post-transcriptional regulations in human respiratory epithelial cells during influenza A virus infection
Conclusion: Compared with other representative state-of-the-art algorithms, the proposed SITPR framework can more effectively identify the activated transcriptional and post-transcriptional regulations simultaneously from a given background network. The idea of SITPR is generally applicable to the analysis of gene regulatory networks in human cells. The results obtained for human respiratory epithelial cells suggest the importance of the transcriptional, post-transcriptional regulations as well as their synergies in the innate immune responses against IAV infection. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - October 4, 2014 Category: Epidemiology Authors: Zhi-Ping LiuHulin WuJian ZhuHongyu Miao Source Type: research

Diphtheria-like illness in a fully immunised child caused by Corynebacterium pseudodiphtheriticum
VA Indumathi, R Shikha, DR SuryaprakashIndian Journal of Medical Microbiology 2014 32(4):443-445Corynebacterium pseudodiphtheriticum is a common commensal flora of the upper respiratory tract in humans. Though the pathogenicity of C. pseudodiphtheriticum is not rare, its role as an opportunistic pathogen is mainly limited to the lower respiratory tract, particularly in patients with underlying systemic conditions or immune-compromisation. We hereby present the first case of C. pseudodiphtheriticum causing diphtheria-like illness affecting the upper respiratory tract of a 6-year-old fully immunised otherwise healthy child. ...
Source: Indian Journal of Medical Microbiology - October 4, 2014 Category: Microbiology Authors: VA IndumathiR ShikhaDR Suryaprakash Source Type: research

A chalcone with potent inhibiting activity against biofilm formation by nontypeable Haemophilus influenzae
In this study, a series of natural and synthetic chalcones with various chemical substituents were evaluated in vitro for their antibiofilm activities against strong biofilm‐forming strains of NTHi. Of the test chalcones, 3‐hydroxychalcone (chalcone 8) exhibited the most potent inhibitory activity, its mean minimum biofilm inhibitory concentration (MBIC50) being 16 μg/mL (71.35 μM), or approximately sixfold more active than the reference drug, azithromycin (MBIC50 419.68 μM). The inhibitory activity of chalcone 8, which is a chemically modified chalcone, appeared to be superior to those of the natural chalcone...
Source: Microbiology and Immunology - October 4, 2014 Category: Microbiology Authors: Duangkamol Kunthalert, Sudarat Baothong, Pichit Khetkam, Suwadee Chokchaisiri, Apichart Suksamrarn Tags: Original Article Source Type: research

Reduced primary care respiratory infection visits following pregnancy and infancy vitamin D supplementation: a randomised‐controlled trial
ConclusionVitamin D3 supplementation during pregnancy and infancyreduces primary care visits for ARIduring early childhood.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 4, 2014 Category: Pediatrics Authors: Cameron C. Grant, Suhina Kaur, Ellen Waymouth, Edwin A. Mitchell, Robert Scragg, Alec Ekeroma, Alistair Stewart, Julian Crane, Adrian Trenholme, Carlos A. Camargo Tags: Regular Article Source Type: research

Duration of Gestation and Mode of Delivery Affect the Genes of Transepithelial Sodium Transport in Pulmonary Adaptation.
Conclusions: In late preterm and early term infants, low expression of ENaC and SGK1 may parallel insufficient lung liquid clearance predisposing to respiratory distress. Lower SGK1 expression after term CD could translate into insufficient sodium and lung liquid absorption. The findings demonstrate a central role for cortisol in regulation of ENaC and potentially perinatal sodium and lung liquid clearance. © 2014 S. Karger AG, Basel. PMID: 25301528 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - October 4, 2014 Category: Perinatology & Neonatology Authors: Janér C, Pitkänen OM, Süvari L, Turpeinen U, Palojärvi A, Andersson S, Helve O Tags: Neonatology Source Type: research

A randomized controlled trial of capnography during sedation in a pediatric emergency setting
Data suggest that capnography is a more sensitive measure of ventilation than standard modalities and detects respiratory depression before hypoxemia occurs. We sought to determine if adding capnography to standard monitoring during sedation of children increased the frequency of interventions for hypoventilation, and whether these interventions would decrease the frequency of oxygen desaturations. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - October 4, 2014 Category: Emergency Medicine Authors: Melissa L. Langhan, Veronika Shabanova, Fang-Yong Li, Steven L. Bernstein, Eugene D. Shapiro Tags: Original Contribution Source Type: research

Snoring – Obnoxious (but medically innocent) noise or wakeup call for sleep medicine?
In the present issue of Sleep Medicine Reviews, there are two articles with complementary reviews of adult and pediatric snoring [1,2]. Both studies acknowledge that snoring is often a marker of obstructive sleep apnea, but they also highlight the greater frequency of this symptom and its potential independent clinical importance. The most important issue raised by both reviews is the persisting question about the significance of snoring in the absence of frank obstructive sleep apnea. Both reviews allude to the assumption that snoring is the mildest form of the obstruction we loosely call “sleep disordered breathing” ...
Source: Sleep Medicine Reviews - October 4, 2014 Category: Sleep Medicine Authors: David M. Rapoport Tags: Guest editorial Source Type: research

The economic effect of extracorporeal membrane oxygenation to support adults with severe respiratory failure in Brazil: a hypothetical analysis
Conclusion: The cost-utility ratio associated with the use of extracorporeal membrane oxygenation in Brazil is potentially acceptable according to this hypothetical study. (Source: Revista Brasileira de Terapia Intensiva)
Source: Revista Brasileira de Terapia Intensiva - October 3, 2014 Category: Intensive Care Source Type: research

A mortality study of workers exposed to insoluble forms of beryllium
This study investigated lung cancer and other diseases related to insoluble beryllium compounds. A cohort of 4950 workers from four US insoluble beryllium manufacturing facilities were followed through 2009. Expected deaths were calculated using local and national rates. On the basis of local rates, all-cause mortality was significantly reduced. Mortality from lung cancer (standardized mortality ratio 96.0; 95% confidence interval 80.0, 114.3) and from nonmalignant respiratory diseases was also reduced. There were no significant trends for either cause of death according to duration of employment or time since first employ...
Source: European Journal of Cancer Prevention - October 3, 2014 Category: Cancer & Oncology Tags: Research Papers: Lifestyle Source Type: research

Effects of different mesenchymal stromal cell sources and delivery routes in experimental emphysema
In conclusion, different MSC sources and administration routes variably reduced elastase-induced lung damage, but IV administration of BM-MSCs resulted in better cardiovascular function and change of the macrophage phenotype from M1 to M2. (Source: Respiratory Research)
Source: Respiratory Research - October 3, 2014 Category: Respiratory Medicine Authors: Mariana AntunesSoraia AbreuFernanda CruzAna TeixeiraMiquéias Lopes-PachecoElga BandeiraPriscilla OlsenBruno DiazChristina TakyiaIsalira FreitasNazareth RochaVera CapelozziDébora XistoDaniel WeissMarcelo MoralesPatricia Rocco Source Type: research

Incidence and outcome of acute lung injury and acute respiratory distress syndrome in the surgical intensive care unit
Conclusion: The incidence and mortality of ARDS was similar to other studies. Identifying those with risk factors for ARDS or mortality will enable appropriate interventional measures. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - October 3, 2014 Category: Intensive Care Authors: Georgene SinghGeorge GladdyTony Thomson ChandyNagamani Sen Source Type: research

Chronic obstructive pulmonary disease and heart rate variability: a literature update
Conclusion: The studies indicate a need for further investigations to guide future therapies to improve the treatment of cardiovascular system in the respiratory diseases. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - October 3, 2014 Category: Epidemiology Authors: Adriano L RoqueVitor E ValentiThais MassettiTalita Dias da SilvaCarlos Bandeira MonteiroFernando R OliveiraÁlvaro Dantas de Almeida JuniorSheylla Nadjane LacerdaGustavo Carreiro PinascoViviane Gabriela NascimentoLuiz Gonzaga Granja FilhoLuiz Carlos de Ab Source Type: research

Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by estradiol and tamoxifen
Estrogen receptor α (ERα+) breast tumors rely on mitochondria (mt) to generate ATP. The goal of this study was to determine how estradiol (E2) and 4-hydroxytamoxifen (4-OHT) affect cellular bioenergetic function in MCF-7 and T47D ERα+ breast cancer cells in serum-replete versus dextran-coated charcoal (DCC)-stripped fetal bovine serum (FBS)-containing medium (‘serum-starved’). Serum-starvation reduced oxygen consumption rate (OCR), extracellular acidification rate (ECAR), ATP-linked OCR, and maximum mt capacity, reflecting lower ATP demand and mt respiration. Cellular respir...
Source: BJ Energy - October 3, 2014 Category: Biochemistry Authors: B N Radde, M M Ivanova, H Xuan Mai, J K Salabei, B G Hill, C M Klinge Tags: BJ Metabolism Source Type: research

The Anatomy of the Dog Soft Palate. III. Histological Evaluation of the Caudal Soft Palate in Brachycephalic Neonates
ABSTRACT A thickened and abnormally long soft palate is mostly involved in the pathogenesis of both nasopharyngeal and oropharyngeal narrowing, affecting the respiratory activity in virtually all of the brachycephalic dogs suffering from Brachycephalic Airway Obstructive Syndrome (BAOS). The morphology of the soft palate in adult mesaticephalic and brachycephalic dogs has been previously described. In this article specimens from brachycephalic dog neonates (N = 10) dead from one to 3 hr after birth of unrelated conditions were collected and histologically evaluated at three transverse levels to describe the microscopic...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 3, 2014 Category: Molecular Biology Authors: Michela Pichetto, Silvana Arrighi, Matteo Gobbetti, Stefano Romussi Tags: Full Length Article Source Type: research

Natural history of angiomyolipoma in lymphangioleiomyomatosis: implications for screening and surveillance
Conclusions: Patients with LAM have a high prevalence of symptomatic angiomyolipoma which can present at any time. Angiomyolipoma in sporadic-LAM have a similar risk of bleeding to those with TSC. All patients should be screened for angiomyolipoma at diagnosis of lung disease by MRI scanning and the tumours require continuous monitoring. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - October 3, 2014 Category: Internal Medicine Authors: Zhao YeohVidya NavaratnamRupesh BhattIan McCaffertyRichard HubbardSimon Johnson Source Type: research

Postoperative intubation time is associated with acute kidney injury in cardiac surgical patients
IntroductionAcute kidney injury (AKI) is a frequent complication after cardiac surgery and is associated with a poor prognosis. Mechanical ventilation is an important risk factor for developing AKI in critically ill patients. Ventilation with high tidal volumes has been associated with postoperative organ dysfunction in cardiac surgical patients. No data are available about the effects of the duration of postoperative respiratory support in the immediate postoperative period on the incidence of AKI in patients after cardiac surgery.MethodWe performed a secondary analysis of 584 elective cardiac surgical patients enrolled i...
Source: Critical Care - October 3, 2014 Category: Intensive Care Authors: Matthias HeringlakeYvonne NowakJulika SchönJens TrautmannAstrid BerggreenEfstratios CharitosHauke Paarmann Source Type: research

Leukemia inhibitory factor protects the lung during respiratory syncytial viral infection
Conclusions: RSV infection in the epithelium induces a network of immune factors to counter infection, primarily in a RIG-I dependent manner. Expression of LIF protects the lung from lung injury and enhanced pathology during RSV infection. (Source: BMC Immunology)
Source: BMC Immunology - October 3, 2014 Category: Allergy & Immunology Authors: Robert ForonjyAbdoulaye DaboNeville CumminsPatrick Geraghty Source Type: research

Thromboxane-Induced Actin Polymerization in Hypoxic Neonatal Pulmonary Arterial Myocytes Involves Cdc42 Signaling.
Abstract In hypoxic pulmonary arterial (PA) myocytes, challenge with thromboxane mimetic U46619 induces marked actin polymerization and contraction, phenotypic features of persistent pulmonary hypertension of the newborn (PPHN). Rho GTPases regulate the actin cytoskeleton. We previously reported U46619-induced actin polymerization in hypoxic PA myocytes occurs independently of the RhoA pathway, and hypothesized involvement of the Cdc42 pathway. PA myocytes grown in normoxia or hypoxia for 72 hrs were stimulated with U46619, then analyzed for Rac/Cdc42 activation by affinity precipitation, PI3K activity by phospho-A...
Source: Am J Physiol Lung Ce... - October 3, 2014 Category: Respiratory Medicine Authors: Fediuk J, Sikarwar AS, Nolette N, Dakshinamurti S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Animal models of bronchopulmonary dysplasia. V: The preterm baboon models.
Abstract Much of the progress in improved neonatal care, particularly management of under-developed preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this chapter we highlight how the preterm baboon model at both140d and 125 d gestation (term equivalent 185d) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-d baboon model extremely relevant to the condition of BPD but there are also critical neurodevelopmental and other end-organ pathological features associated with t...
Source: Am J Physiol Lung Ce... - October 3, 2014 Category: Respiratory Medicine Authors: Yoder BA, Coalson JJ Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Carl Wilhelm Scheele, the discoverer of oxygen, and a very productive chemist.
Abstract Carl Wilhelm Scheele (1742-1786) has an important place in the history of the discovery of respiratory gases because he was undoubtedly the first person to prepare oxygen and describe some of its properties. In spite of this, his contributions have often been overshadowed by those of Joseph Priestley and Antoine Lavoisier who also played critical roles in preparing the gas and understanding its nature. Sadly, Scheele was slow to publish his discovery and therefore Priestley is rightly recognized as the first person to report the preparation of oxygen. Having said this, the thinking of both Scheele and Prie...
Source: Am J Physiol Lung Ce... - October 3, 2014 Category: Respiratory Medicine Authors: West JB Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research