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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Compartment differences of inflammatory activity in chronic obstructive pulmonary disease
Conclusion: Saliva which is convenient to collect and analyse, may be suitable for biomarker assessment of disease activity in COPD. An attenuated TNF-? expression was demonstrated by both protein and mRNA analyses in different compartments suggesting that TNF-? response is altered in moderate and severe COPD. Shedding of TNFR1 or TNFR2 is similarly regulated irrespective of airflow limitation. (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2014 Category: Respiratory Medicine Authors: Jie JiIda von SchéeleJan BergströmBo BillingBarbro DahlénAnn-Sofie LantzKjell LarssonLena Palmberg Source Type: research

Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity
Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist and are always present in patients with aspirin exacerbated respiratory disease (AERD). Although the pathogenic mechanisms of this condition are still unknown, AERD may be due, at least in part, to an imbalance in eicosanoid metabolism (increased production of cysteinyl leukotrienes (CysLTs) and reduced biosynthesis of prostaglandin (PG) E2), possibly increasing and perpetuating the process of inflammation. PGE2 results from the metabolism of arachidonic acid (AA) by cyclooxygenase (COX) enzymes, and seems to play a central role in homeostasis ...
Source: Respiratory Research - August 26, 2014 Category: Respiratory Medicine Authors: Liliana Machado-CarvalhoJordi Roca-FerrerCésar Picado Source Type: research

Primary ciliary dyskinesia
(PCD) is an autosomal recessive disorder of cilia structure and function, leading to chronic infections of the respiratory tract, fertility problems and disorders of organ laterality. Making a definitive diagnosis is challenging, utilizing characteristic phenotypes, ciliary functional and ultra-structural defects in addition to newer screening tools such as nasal nitric oxide and genetic testing. There are 21 known PCD causing genes and in the future, comprehensive genetic testing may help diagnosis young infants prior to developing symptoms thus improving survival. Therapy includes surveillance of pulmonary function and ...
Source: QJM - August 26, 2014 Category: Internal Medicine Authors: Lobo, L. J., Zariwala, M. A., Noone, P. G. Tags: Review Source Type: research

Magnetic Resonance Imaging Predictors for Respiratory Failure after Cervical Spinal Cord Injury
Acute spinal cord injury is one of the causes of morbidity and mortality in teenagers and adults, and approximately one-third of these patients have cervical spinal cord injury (CSCI) [1]. Pulmonary dysfunction accounts for the largest proportion of complications after a spinal insult and includes ventilation failure, atelectasis, pneumonia, and pleural effusion [2–4]. The respiratory sequelae result from a variety of mechanisms, consisting of expiratory muscle weakness, retained secretions, bronchial mucus hypersecretion, ileus with embarrassment of diaphragmatic excursion, an increased risk of aspiration of gastric con...
Source: Clinical Neurology and Neurosurgery - August 26, 2014 Category: Neurosurgery Authors: Yu-Hua Huang, Chien-Yu Ou Source Type: research

Chronic Ethanol Exposure Selectively Inhibits the Influenza-Specific CD8 T Cell Response During Influenza A Virus Infection.
CONCLUSIONS: These findings highlight the previously unrecognized depth of the lesion in the IAV-specific CD8 T cell response during chronic EtOH consumption. Given the important role CD8 T cell immunity plays in control of IAV, these findings may aid in the development of vaccination and/or therapeutic strategies to reverse these defects in the CD8 T cell response and reduce serious disease outcomes associated with IAV infections in alcoholics. PMID: 25160044 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - August 26, 2014 Category: Addiction Authors: Hemann EA, McGill JL, Legge KL Tags: Alcohol Clin Exp Res Source Type: research

The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems.
Abstract Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). In the central nervous system, pharmacological inhibition of PDE2 results in boosted cAMP and/or cGMP signaling, which is responsible for series of changes in protein expression relevant to psychiatric and learning and memory disorders, such as depression, anxiety, and cognition deficits in Alzheimer's disease. In the periphery, inhibition of PDE2 exhibits beneficial effects in the diseased cardiovascular system, ...
Source: Current Pharmaceutical Design - August 26, 2014 Category: Drugs & Pharmacology Authors: Zhang C, Yu Y, Ruan L, Wang C, Pan J, Klabnik J, Lueptow L, Zhang HT, O'Donnell JM, Xu Y Tags: Curr Pharm Des Source Type: research

Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE): Protocol and preliminary data.
Abstract Chronic obstructive pulmonary disease (COPD) is a multisystem disease. Established comorbidities include cardiovascular disease, osteoporosis, loss of muscle mass and function, depression, and impaired quality of life. The natural history is not well understood. The Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) is a longitudinal study of comorbidities in COPD. The primary aims are to delineate the progression and interrelationships of cardiovascular disease and associated comorbidities. Each year ARCADE aims to recruit 250 patients diagnosed with COPD and 50 comparators (free from respi...
Source: Chronic Respiratory Disease - August 26, 2014 Category: Respiratory Medicine Authors: Gale NS, Albarrati AM, Munnery MM, Munnery IC, Irfan M, Bolton CE, Rambaran CN, Singer RM, Cockcroft JR, Shale DJ Tags: Chron Respir Dis Source Type: research

Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients.
Conclusion: Compared to PSV, proportional modes favored tidal volume variability. The weak ∫EAdi-PTPdi linear relationship during NAVA and poor triggering function during PAV+ may limit the effectiveness of these modes to proportionally assist the inspiratory effort. PMID: 25169117 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Akoumianaki E, Prinianakis G, Kondili E, Malliotakis P, Georgopoulos D Tags: Respir Physiol Neurobiol Source Type: research

Gabapentin as a Potential Treatment for Cough Syncope.
PMID: 25161306 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Wu CH, Gunasekara K, Hull JH, Bikov A, Morris AJ, Usmani OS Tags: Respir Care Source Type: research

The Necessity of Histology.
PMID: 25161305 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Nataraj RT, Fladeland DA, Cockcroft DW Tags: Respir Care Source Type: research

An Innovative Childhood Asthma Score Predicts the Need for Bronchodilator Nebulization in Children With Acute Asthma Independent of Auscultative Findings.
CONCLUSIONS: Using a cutoff value of 4, the newly developed CAS accurately predicts the requirement for bronchodilator nebulization in children with acute asthma without use of auscultative findings. PMID: 25161304 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Kamps AW, Veeger NJ, Heijsman SM Tags: Respir Care Source Type: research

Association of Influenza-Like Illness and Climatic Parameters With Hemoptysis.
CONCLUSIONS: There is a strong long running relationship between severe hemoptysis and low monthly mean temperature. A weaker association of hemoptysis with influenza activity was also found. PMID: 25161303 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Garcia-Olivé I, Fiz JA, Sanz-Santos J, Martínez-Rivera C, Prats M, Ruiz-Manzano J Tags: Respir Care Source Type: research

Effect of Drug Targeting Nebulization on Lung Deposition: A Randomized Crossover Scintigraphic Comparison Between Central and Peripheral Delivery.
CONCLUSIONS: This study shows for the first time that choosing 2 different specific drug targeting nebulization modes does not influence the amount of drug delivered into the lung in healthy male subjects. Moreover, the modes do not modify the site of deposition under the conditions of our study. PMID: 25161302 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Reychler G, Aubriot AS, Depoortere V, Jamar F, Liistro G Tags: Respir Care Source Type: research

Double Lumen Endotracheal Tube for Percutaneous Tracheostomy.
CONCLUSIONS: Use of the DLET during percutaneous dilational tracheostomy allows fiberoptic bronchoscopy without imposing excessive airway resistance. Reduced tube resistance during this procedure may confer additional safety in what is well known to be a hazardous procedure. PMID: 25161301 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Vargas M, Servillo G, Tessitore G, Aloj F, Brunetti I, Arditi E, Salami D, Kacmarek RM, Pelosi P Tags: Respir Care Source Type: research

Endobronchial Argon Plasma Coagulation for Treatment of Dieulafoy Disease.
Abstract Dieulafoy disease of the bronchus is a rare condition. A 28-y-old male patient with recurrent exacerbations of hemoptysis (producing up to 300 mL) over the previous 4 y was admitted to our hospital following an acute episode. A 3-mm sessile lesion covered with somewhat ulcerated smooth mucosa was detected at the distal end of the left main bronchus, at the entrance to the upper lobe bronchus. Bleeding was controlled by argon plasma coagulation, and total coagulation of the lesion was also therapeutic. The patient has been followed for 2 y with no further bleeding. In the very few reported cases of Dieulafo...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Dalar L, Sökücü SN, Ozdemir C, Büyükkale S, Altın S Tags: Respir Care Source Type: research

Ventilation Efficacy of Video-Laryngoscope Equipped With a Ventilation Feature.
CONCLUSIONS: Video-laryngoscopes equipped with a ventilation feature provided effective VT in simulated clinical scenarios. Further clinical study is required to validate these findings. PMID: 25161299 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Oto J, Chenelle CT, Su Z, Sun MQ, Jiang Y, Kacmarek RM Tags: Respir Care Source Type: research

Complications With Utilization of Positive-Pressure Devices in a Young Man With Duchenne Muscular Dystrophy.
Abstract Because of the progressive muscle weakness they experience, patients with Duchenne muscular dystrophy frequently utilize positive-pressure devices to maintain adequate bronchial hygiene and ventilation. This case illustrates the course of a 19-y-old male who presented with a perforated right tympanic membrane (TM) following the use of these devices. Perforation of the TM while utilizing positive-pressure devices is a rarely reported event. A challenging aspect in this case was balancing the reduction of pressures and maintaining adequate ventilation while at the same time allowing the TM to heal. PMID:...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Gee SL, Lowe GR, Warren RH Tags: Respir Care Source Type: research

Exogenous Lipoid Pneumonia Successfully Treated With Bronchoscopic Segmental Lavage Therapy.
In conclusion, a case of exogenous lipoid pneumonia was successfully treated with bronchoscopic segmental lavage therapy. PMID: 25161297 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Nakashima S, Ishimatsu Y, Hara S, Kitaichi M, Kohno S Tags: Respir Care Source Type: research

Tissue Hypoxia: Implications for the Respiratory Clinician.
Abstract Oxygen is essential for normal aerobic metabolism in mammals. Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low blood oxygen content and pressure), impaired oxygen delivery, and impaired cellular oxygen uptake/ utilization. Many compensatory mechanisms exist at the global, regional, and cellular levels to allow cells to function in a hypoxic environment. Clinical management of tissue hypoxia usually focuses on global hypoxemia and oxygen delivery. As we move into the future, the clinical focus needs to change to assessing and mana...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: MacIntyre NR Tags: Respir Care Source Type: research

Endotoxin depletion of recombinant protein preparations through their preferential binding to histidine tags.
Abstract The presence of endotoxins in preparations of recombinantly produced therapeutic proteins poses serious problems for patients. Endotoxins can cause fever, respiratory distress syndromes, intravascular coagulation or endotoxic shock. A number of methods have been devised to remove endotoxins from protein preparations, using separation procedures based on molecular mass or charge properties. Most of the methods are limited in their endotoxin removal capacities and lack general applicability. We are describing a biotechnological approach for endotoxin removal. This strategy exploits the observation that endot...
Source: Analytical Biochemistry - August 26, 2014 Category: Biochemistry Authors: Mack L, Brill B, Delis N, Groner B Tags: Anal Biochem Source Type: research

Nanotubes in the human respiratory tract - Deposition Modeling.
Abstract Deposition of inhaled single-wall carbon nanotubes (SWCNT) and multi-wall carbon nanotubes (MWCNT) in the respiratory tract was theoretically investigated for various age groups (infants, children, adolescents, and adults). Additionally, possible effects of the inhalative flow rate on nanotube deposition were simulated for adult lungs. Theoretical computations were based on the aerodynamic diameter concept and the assumption of particles being randomly transported through a stochastic (close-to-realistic) lung structure. Deposition of nanotubes was calculated by application of well validated empirical depo...
Source: Medical Physics - August 26, 2014 Category: Physics Authors: Sturm R Tags: Z Med Phys Source Type: research

Maternal immunization with chimpanzee adenovirus expressing RSV fusion protein protects against neonatal RSV pulmonary infection.
In this study we tested the efficacy of maternal immunization with a chimpanzee adenovirus expressing codon-optimized RSV fusion protein (AdC7-Fsyn) to protect infants against RSV infection. Single intranasal immunization of mice by AdC7-Fsyn induced robust anti-RSV systemic and mucosal immunity that protected against RSV without causing vaccine-enhanced RSV disease. RSV humoral immunity was transferred to pups born to immunized mothers that provided protection against RSV. Immunization with AdC7-Fsyn was effective even in the presence of Ad5 preimmunity. The maternally derived immunity was durable with the half-life of 14...
Source: Vaccine - August 26, 2014 Category: Allergy & Immunology Authors: Sharma A, Wendland R, Sung B, Wu W, Grunwald T, Worgall S Tags: Vaccine Source Type: research

Attenuation of highly pathogenic porcine reproductive and respiratory syndrome virus by inserting an additional transcription unit.
In this study, genome instability was found when a highly pathogenic PRRSV (HP-PRRSV) strain was inserted by an additional transcription unit in which a foreign gene GFP was expressed from TRS2 while a copy of TRS6 drove ORF2a/b transcription. Structural protein gene-deleted genomes resulted from enhanced RNA recombinations were identified in the recombinant virus rHV-GFP. Moreover, rHV-GFP replicated slower than parental viruses, and caused less cell death in porcine alveolar macrophages. Pigs infected with rHV-GFP survived with no or mild syndromes, whereas all pigs infected with parental viruses died within 12 days. Our...
Source: Vaccine - August 26, 2014 Category: Allergy & Immunology Authors: Wang L, Hou J, Gao L, Guo XK, Yu Z, Zhu Y, Liu Y, Tang J, Zhang H, Feng WH Tags: Vaccine Source Type: research

Non-invasive ventilation after surgery.
Abstract After surgery, hypoxemia and/or acute respiratory failure (ARF) mainly develop following abdominal and/or thoracic surgery. Anesthesia, postoperative pain and surgery will induce respiratory modifications: hypoxemia, pulmonary volumes decrease and atelectasis associated to a restrictif syndrome and a diaphragm dysfunction. Maintenance of adequate oxygenation in the postoperative period is of major importance, especially when pulmonary complications such as ARF occur. Although invasive endotracheal mechanical ventilation has remained the cornerstone of ventilatory strategy for many years for severe acute re...
Source: Annales Francaises d'Anesthesie et de Reanimation - August 26, 2014 Category: Anesthesiology Authors: Jaber S, De Jong A, Castagnoli A, Futier E, Chanques G Tags: Ann Fr Anesth Reanim Source Type: research

Which preoperative respiratory evaluation?
Abstract The preoperative respiratory evaluation aims at predicting the occurrence of postoperative respiratory complications (PORC), such as: atelectasis, pulmonary infection (bronchitis and pneumonia), acute ventilatory distress, pleural effusion, prolonged mechanical ventilation, exacerbation of chronic respiratory disease and bronchospasm. The incidence of (PORC) all surgeries combined is 6.8%. Individual surgical and anesthetic factors are impacting on the occurrence of PORC. Simple scores, including anamnestic data, clinical examination and some biological parameters were validated to assess the risk of PORC ...
Source: Annales Francaises d'Anesthesie et de Reanimation - August 26, 2014 Category: Anesthesiology Authors: Zraier S, Haouache H, Dhonneur G Tags: Ann Fr Anesth Reanim Source Type: research

Twenty-five year trends in prevalence of chronic bronchitis and the trends in relation to smoking
The present study examines how the trends in the prevalence of chronic bronchitis during the last three decades associate with changes in smoking habits during the same period. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 26, 2014 Category: Respiratory Medicine Authors: Margit K. Pelkonen, Irma-Leena K. Notkola, Tiina K. Laatikainen, Heikki O. Koskela Source Type: research

Reducing hospital admissions and improving the diagnosis of COPD in Southampton City: methods and results of a 12-month service improvement project.
CONCLUSIONS: The use of medical intelligence to investigate the underlying processes of COPD hospital admissions led to an effective intervention delivered in a consultant-led model. PMID: 25141877 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - August 25, 2014 Category: Respiratory Medicine Authors: Wilkinson T, North M, Bourne SC Tags: NPJ Prim Care Respir Med Source Type: research

Roche To Acquire Intermune
Acquisition: Swiss drugmaker expands in respiratory disease area with purchase of one-drug firm (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - August 25, 2014 Category: Chemistry Authors: Ann M. Thayer Source Type: research

Respiratory Services of WNY expands into Rochester market
A growing respiratory services firm in Western New York is expanding outside the region through acquisition. Subscribe to one of our free daily newsletters. From our daily Morning and Afternoon Editions to weekly customized newsletters that include national headlines for a range of industries. Respiratory Services of Western New York Inc., a Cheektowaga-based provider, has completed the purchase of Durable Medical Equipment and Supplies Ltd., including locations in LeRoy and Honeoye Falls. Terms… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - August 25, 2014 Category: American Health Authors: Tracey Drury Source Type: research

Mini-symposium: Childhood obesity and its impact on respiratory wellbeing: Editorial title: Childhood obesity is the global warming of healthcare
The discussion of obesity and its detrimental impact upon recent generations has sparked much interest but comparatively little success in implementing preventative strategies . The rates of child overweight and obesity continue to climb internationally in a problem that is no longer isolated to the developed world . Indeed, in a country like Australia that prides itself on its sporty outdoor lifestyles, we presently have 26% of our children as overweight or obese and 63% of our adult population similarly disposed. Moreover, the issue is of greater urgency in our indigenous population, with the proportion of overweight and...
Source: Paediatric Respiratory Reviews - August 25, 2014 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Tags: Mini-Symposium: Obesity and the Respiratory system Source Type: research

Index
Note: Page numbers of article titles are in boldface type. Abuse (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - August 25, 2014 Category: Respiratory Medicine Source Type: research

Forthcoming Issues
Acute Respiratory Distress Syndrome (ARDS) Lorraine B. Ware, Julie A. Bastarache, and Carolyn Calfee, Editors (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - August 25, 2014 Category: Respiratory Medicine Source Type: research