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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Application of impulse oscillometry in respiratory system evaluation in elderly patients.
CONCLUSIONS: As R5-R20 is regarded as a measure of peripheral airways resistance, IOS may serve as an interesting complementary or alternative method for spirometry in elderly subjects for evaluation of the state of respiratory system. PMID: 24964235 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - June 28, 2014 Category: Respiratory Medicine Authors: Tomalak W, Czajkowska-Malinowska M, Radliński J Tags: Pneumonol Alergol Pol Source Type: research

[Microbiological diagnostics in the patients with cystic fibrosis].
PMID: 24964234 [PubMed - in process] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - June 28, 2014 Category: Respiratory Medicine Authors: Augustynowicz-Kopeć E Tags: Pneumonol Alergol Pol Source Type: research

Treatment of asthma exacerbations with the human-powered nebuliser: a randomised parallel-group clinical trial.
Conclusions:The human-powered nebuliser compressor is equivalent to a standard nebuliser compressor for the treatment of mild-to-moderate asthma. (Funded by the Opus Dean's Fund, Marquette University College of Engineering; ClinicalTrials.gov NCT01795742.). PMID: 24965834 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - June 28, 2014 Category: Primary Care Authors: Hallberg CJ, Lysaught MT, Najarro RA, Cea Gil F, Villatoro C, Diaz de Uriarte AC, Olson LE Tags: NPJ Prim Care Respir Med Source Type: research

Streptococcus pneumoniae antigen in urine: Diagnostic usefulness and impact on outcome of bacteraemic pneumococcal pneumonia in a large series of adult patients
ConclusionsThe sensitivity of the immunochromatographic urinary antigen test was 74.6% and positive results were associated with poorer clinical outcome. We therefore recommend systematic use of this test when pneumonia is diagnosed in the emergency department. (Source: Respirology)
Source: Respirology - June 28, 2014 Category: Respiratory Medicine Authors: Rafael Zalacain, Alberto Capelastegui, Luis Alberto Ruiz, Amaia Bilbao, Ainhoa Gomez, Ane Uranga, Pedro P. España Tags: Original Article Source Type: research

Estimates of mortality attributable to influenza and RSV in the United States during 1997–2009 by influenza type or subtype, age, cause of death, and risk status
ConclusionsInfluenza‐attributable mortality was highest in older and high‐risk individuals and mortality in children was higher than reported in passive Centers for Disease Control and Prevention surveillance. Influenza B‐attributable mortality was higher than A in four of 12 seasons. Our estimates represent an updated assessment of influenza‐attributable mortality in the USA. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - June 28, 2014 Category: Infectious Diseases Authors: Gonçalo Matias, Robert Taylor, François Haguinet, Cynthia Schuck‐Paim, Roger Lustig, Vivek Shinde Tags: Original Article Source Type: research

Etiology of acute bronchiolitis and the relationship with meteorological conditions in hospitalized infants in China.
CONCLUSION: Although respiratory syncytial virus was the most frequent pathogen in patients in whom bronchiolitis was diagnosed, other pathogens, including newly identified viruses and MP, also play important roles in infants with bronchiolitis. Different respiratory pathogens have different traits in response to certain meteorological conditions. PMID: 24961189 [PubMed - in process] (Source: J Formos Med Assoc)
Source: J Formos Med Assoc - June 28, 2014 Category: Journals (General) Authors: Chen ZR, Ji W, Wang YQ, Yan YD, Shao XJ, Zhang XL, Xu J Tags: J Formos Med Assoc Source Type: research

Reduction in the use of diagnostic tests in infants with risk factors for early-onset neonatal sepsis does not delay antibiotic treatment.
CONCLUSION: Reduction of diagnostic tests such as CBC and CRP does not delay initiation of antibiotic treatment in infants with suspected EOS. The importance of clinical examination in infants with risk factors for EOS should be emphasised. PMID: 24964177 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - June 28, 2014 Category: Journals (General) Authors: Duvoisin G, Fischer C, Maucort-Boulch D, Giannoni E Tags: Swiss Med Wkly Source Type: research

An autopsy study of combined pulmonary fibrosis and emphysema: correlations among clinical, radiological, and pathological features
Conclusions: TWCLs were only observed in the CPFE patients. They were classified as lesions with coexistent fibrosing interstitial pneumonia and emphysema, and should be considered an important pathological and radiological feature of CPFE. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - June 28, 2014 Category: Respiratory Medicine Authors: Minoru InomataSoichiro IkushimaNobuyasu AwanoKeisuke KondohKohta SatakeMasahiro MasuoYuji KusunokiAtsuko MoriyaHiroyuki KamiyaTsunehiro AndoNoriyo YanagawaToshio KumasakaTakashi OguraFumikazu SakaiArata AzumaAkihiko GemmaTamiko Takemura Source Type: research

Trimodality Therapy for Superior Sulcus Non-Small Cell Lung Cancer: Southwest Oncology Group-Intergroup Trial S0220.
CONCLUSIONS: Although trimodality therapy provides excellent R0 and local control, only 66% of patients underwent surgical resection and only 45% completed the treatment regimen. Even in this subset, distant recurrence continues to be a major problem, particularly brain-only relapse. Future strategies to improve treatment outcomes in this patient population must increase the effectiveness of systemic therapy and reduce the incidence of brain-only metastases. PMID: 24980603 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - June 28, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kernstine KH, Moon J, Kraut MJ, Pisters KM, Sonett JR, Rusch VW, Thomas CR, Waddell TK, Jett JR, Lyss AP, Keller SM, Gandara DR, American College of Surgeons Oncology Group, Cancer and Leukemia Group B, Eastern Cooperative Oncology Group, North Central Ca Tags: Ann Thorac Surg Source Type: research

Ion flux in the lung: virus-induced inflammasome activation.
Abstract Innate immunity has a primary role in lung antimicrobial defenses. The inflammasome has evolved for this purpose and is an important surveillance system that, when triggered, fights infection and eliminates pathogens. However, there is growing evidence that the inflammasome also plays a role in the pathogenesis of acute and chronic respiratory disease. Inflammasomes contribute to both the clearance of the pathogen as well as its pathogenesis - depending on the amount of inflammation triggered. How respiratory viruses trigger inflammasome activation remains unclear. Emerging evidence shows that ion flux is ...
Source: Trends in Microbiology - June 28, 2014 Category: Microbiology Authors: Triantafilou K, Triantafilou M Tags: Trends Microbiol Source Type: research

[Voluminous plexiform neurofibromas of the neck region in neurofibromatosis 1].
CONCLUSIONS. The VPNFN are histologically benign tumors. Those located in the larynx must be removed because of the respiratory problems, but it is not necessary in cases with other locations despite the voluminous size that can reach in some patients with great displacement of the surrounding organs. The analysis of the results of our series may demonstrate that al least the extralaryngeal tumors only grow to 11-12 years of age. This possibility may make recommendable to retard the surgical treatment as much as possible in cases that it is not necessary. PMID: 24965926 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - June 27, 2014 Category: Neurology Authors: Pascual-Castroviejo I, Pascual-Pascual SI, Velazquez-Fragua R, Viano J, Quinones-Tapia D, Lopez-Barea F Tags: Rev Neurol Source Type: research

Assessment of the Middle East respiratory syndrome coronavirus (MERS-CoV) epidemic in the Middle East and risk of international spread using a novel maximum likelihood analysis approach.
PMID: 24957746 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - June 27, 2014 Category: Infectious Diseases Authors: Poletto C, Pelat C, Levy-Bruhl D, Yazdanpanah Y, Boelle P, Colizza V Tags: Euro Surveill Source Type: research

Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014.
PMID: 24957745 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - June 27, 2014 Category: Infectious Diseases Authors: Reusken C, Farag E, Jonges M, Godeke G, El-Sayed A, Pas S, Raj V, Mohran K, Moussa H, Ghobashy H, Alhajri F, Ibrahim A, Bosch B, Pasha S, Al-Romaihi H, Al-Thani M, Al-Marri S, AlHajri M, Haagmans B, Koopmans M Tags: Euro Surveill Source Type: research

Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity.
PMID: 24957744 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - June 27, 2014 Category: Infectious Diseases Authors: Hemida M, Perera R, Al Jassim R, Kayali G, Siu L, Wang P, Chu K, Perlman S, Ali M, Alnaeem A, Guan Y, Poon L, Saif L, Peiris M Tags: Euro Surveill Source Type: research

Surfactant administration in spontaneous breathing with N-CPAP for RDS.
Abstract Surfactant administration in spontaneous breathing with N-CPAP seems to be a promising approach in the management of neonatal RDS. Both recent RCTs and single centre experience have shown feasibility and good respiratory outcomes with this approach even in extremely preterm infants with respiratory failure. The results of these studies seem to demonstrate that avoiding mechanical ventilation and manual inflation (therefore the risk of high positive pressure and inappropriate tidal volume) it is possible to reduce the risk of VILI and the evolution towards BPD. Further large clinical studies are needed to c...
Source: Acta Bio-Medica : Atenei Parmensis - June 27, 2014 Category: Journals (General) Authors: Lista G, Castoldi F Tags: Acta Biomed Source Type: research

Lung ultrasound: diagnostic and therapeutic issues.
Conclusion: The use of LUS in neonates may indicatein real time the diagnosis of the respiratory disease. Should be considered as an extension of the clinicalexam and must be done by the clinician in charge of the patient. PMID: 24957343 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - June 27, 2014 Category: Journals (General) Authors: Cattarossi L Tags: Acta Biomed Source Type: research

Weaning from invasive respiratory support in newborn: is there just one strategy?
Abstract Despite a even more frequent use to non-invasive respiratory support, mechanical ventilation is stilloften necessary for supporting premature infants with lung disease. Protracted mechanical ventilation is associatedwith increased morbidity and mortality and thus the earliest weaning from invasive respiratory supportis desirable. Weaning protocols may be helpful in achieving more rapid reduction in support. However,no consensus has been reached on criteria to identify when patients are ready to wean or how to achieve it. Inthis article, available evidence is reviewed and reasonable evidence-based recommend...
Source: Acta Bio-Medica : Atenei Parmensis - June 27, 2014 Category: Journals (General) Authors: Ventura ML, Fedeli T, Ciarmoli E, Tagliabue P Tags: Acta Biomed Source Type: research

Lung recruitment strategy and surfactant in delivery room.
Abstract The aim of neonatal resuscitation is to establish an effective ventilation, avoiding lung damage. PEEP and T-piece use, as well as Sustained Lung Inflation, lower O2 target and appropriately timed surfactant administration analyzed. A new "gentle" respiratory approach in delivery room can improve newborn respiratory outcome. PMID: 24957339 [PubMed - in process] (Source: Acta Bio-Medica : Atenei Parmensis)
Source: Acta Bio-Medica : Atenei Parmensis - June 27, 2014 Category: Journals (General) Authors: Gargano G, Braibanti S Tags: Acta Biomed Source Type: research

Death from 1918 pandemic influenza during the First World War: a perspective from personal and anecdotal evidence
The Meuse‐Argonne offensive, a decisive battle during the First World War, is the largest frontline commitment in American military history involving 1·2 million U.S. troops. With over 26 000 deaths among American soldiers, the offensive is considered “America's deadliest battle”. The Meuse‐Argonne offensive coincided with the highly fatal second wave of the influenza pandemic in 1918. In Europe and in U.S. Army training camps, 1918 pandemic influenza killed around 45 000 American soldiers making it questionable which battle should be regarded “America's deadliest”. The origin of the influenza pandemic has ...
Source: Influenza and Other Respiratory Viruses - June 27, 2014 Category: Infectious Diseases Authors: Peter C. Wever, Leo Bergen Tags: Review Article Source Type: research

The chromatin remodeling protein CHD7, mutated in CHARGE syndrome, is necessary for proper craniofacial and tracheal development
Conclusions: Conditional deletion of Chd7 in ectodermal and endodermal derivatives (Foxg1‐Cre) or migrating neural crest cells (Wnt1‐Cre) results in varied and more severe craniofacial defects than in Chd7Gt/+ mice. These studies indicate that CHD7 has an important, dosage‐dependent role in development of several different craniofacial tissues. Developmental Dynamics, 2014. © 2014 Wiley Periodicals, Inc. (Source: Developmental Dynamics)
Source: Developmental Dynamics - June 27, 2014 Category: Molecular Biology Authors: Ethan D. Sperry, Elizabeth A. Hurd, Mark A. Durham, Elyse N. Reamer, Adam B. Stein, Donna M. Martin Tags: Research Article Source Type: research

Long-term effects of severe lower respiratory tract infections in early childhood
Although it is widely believed that severe lower respiratory tract infection (LRTI) in early childhood is associated with later onset of chronic respiratory disease, the data are not conclusive. This is partly because it is possible that severe LRTI and chronic respiratory disease share common antecedents. In addition, even though earlier studies have shown an association, they have been based on relatively small populations. In this issue of The Journal, a longitudinal population-based study is reported by Szabo et al. They have used patient-level administrative data from public databases, which cover almost all of the po...
Source: The Journal of Pediatrics - June 27, 2014 Category: Pediatrics Authors: Robert W. Wilmott Tags: The Editors' Perspectives Source Type: research

A comparative study of the svm and k-nn machine learning algorithms for the diagnosis of respiratory pathologies using pulmonary acoustic signals
Conclusion: Although the data used to train and test the classifiers are limited, the classification accuracies found are satisfactory. The K-nn classifier was better than the SVM classifier for the discrimination of pulmonary acoustic signals from pathological and normal subjects obtained from the RALE database. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - June 27, 2014 Category: Epidemiology Authors: Rajkumar PalaniappanKenneth SundarajSebastian Sundaraj Source Type: research

Impaired macrophage phagocytosis of bacteria in severe asthma
Conclusions: Persistence of bacteria in the lower airways may result partly from a reduced phagocytic capacity of macrophages for bacteria. This may contribute to increased exacerbations, airway colonization and persistence of inflammation. (Source: Respiratory Research)
Source: Respiratory Research - June 27, 2014 Category: Respiratory Medicine Authors: Zhike LiangQingling ZhangCatherine ThomasKirandeep ChanaDavid GibeonPeter BarnesKian ChungPankaj BhavsarLouise Donnelly Source Type: research

SMOKE IT! Promoting a change of opiate consumption pattern - from injecting to inhaling
Conclusions: Targeted media and personal intervention in association with the dispensation of attractive drug use equipment can motivate opiate users to change their method of drug use. The main reason for inhalative use is that it is significantly less dangerous, measured by the indicators 'overdose' and 'viral infections'. All drop-in centres should expand their syringe-exchange services to include the dispensation of smoking foils. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - June 27, 2014 Category: Epidemiology Authors: Heino Johann StöverDirk Schäffer Source Type: research

Health hazards associated with nanomaterials
Nanotechnology is a major scientific and economic growth area and presents a variety of hazards for human health and environment. It is widely believed that engineered nanomaterials will be increasingly used in biomedical applications (as therapeutics and as diagnostic tools). However, before these novel materials can be safely applied in a clinical setting, their toxicity needs to be carefully assessed. Nanoscale materials often behave different from the materials with a larger structure, even when the basic material is same. Many mammals get exposed to these nanomaterials, which can reach almost every cell of the mammali...
Source: Toxicology and Industrial Health current issue - June 27, 2014 Category: Toxicology Authors: Pattan, G., Kaul, G. Tags: Articles Source Type: research

Rhodovulum mangrovi sp. nov., a phototrophic alphaproteobacterium isolated from a sediment sample of Coringa mangrove forest, India.
Abstract A novel Gram-staining negative purple non-sulfur bacterium, AK41T, was isolated from a sediment sample collected from Coringa mangrove forest, Andhra Pradesh, India. A red-brownish coloured culture was obtained on modified Pfennig medium after enrichment with 2% NaCl and 0.3% pyruvate under 2000 lux of illumination. Individual cell is ovoid-rod shaped and non motile. Bacteriochlorophyll a and carotenoids of the spheroidene series were present as photosynthetic pigments. Strain AK41T was halophilic and grew photoheterotrophically with a number of organic compounds as carbon source and electron donor. It was...
Source: International Journal of Systematic and Evolutionary Microbiology - June 27, 2014 Category: Microbiology Authors: Nupur N, Srinivas TN, Takaichi S, Anil Kumar P Tags: Int J Syst Evol Microbiol Source Type: research

Blood pressure is maintained during dehydration by hypothalamic PVN driven tonic sympathetic nerve activity.
This article is protected by copyright. All rights reserved. PMID: 24973410 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - June 27, 2014 Category: Physiology Authors: Holbein WW, Bardgett ME, Toney GM Tags: J Physiol Source Type: research

Pelagibaca abyssi sp. nov., of the family Rhodobacteraceae, isolated from deep-sea water.
Abstract A Gram-stain negative, oval-shaped, aerobic, catalase and oxidase-positive bacterium, designated JLT2014(T), was isolated from a deep-seawater sample (obtained at a 2,000 m depth) of the Southeastern Pacific Ocean. The dominant fatty acids were identified as C18:1ω7c/C18:1ω6c, C16:0 and C10:0 3-OH, which altogether represented 60.1 % of the total. The predominant respiratory quinone was identified as Q-10. The G+C content of genomic DNA was determined to be 66.4 mol %. The major polar lipids were identified as phosphatidylethanolamine and diphosphatidylglycerol. Phylogenetic analysis based on the 16S...
Source: Antonie van Leeuwenhoek - June 27, 2014 Category: Microbiology Authors: Lin Y, Tang K, Li S, Liu K, Sun J, Jiao N Tags: Antonie Van Leeuwenhoek Source Type: research

Experience with the Avalon® bicaval double-lumen veno-venous cannula for neonatal respiratory ECMO.
CONCLUSIONS: The Avalon(®) dual-lumen veno-venous cannula can be used for respiratory ECMO in the neonatal population. However, as the incidence of right atrial perforation is not negligible, we suspended its used in this group of patients. PMID: 24972812 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - June 27, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Speggiorin S, Robinson S, Harvey C, Westrope C, Faulkner G, Kirkland P, Peek G Tags: Perfusion Source Type: research

Antigen-Pulsed Bone Marrow-Derived and Pulmonary Dendritic Cells Promote Th2 Cell Responses and Immunopathology in Lungs during the Pathogenesis of Murine Mycoplasma Pneumonia.
Abstract Mycoplasmas are a common cause of pneumonia in humans and animals, and attempts to create vaccines have not only failed to generate protective host responses, but they have exacerbated the disease. Mycoplasma pulmonis causes a chronic inflammatory lung disease resulting from a persistent infection, similar to other mycoplasma respiratory diseases. Using this model, Th1 subsets promote resistance to mycoplasma disease and infection, whereas Th2 responses contribute to immunopathology. The purpose of the present study was to evaluate the capacity of cytokine-differentiated dendritic cell (DC) populations to ...
Source: Journal of Immunology - June 27, 2014 Category: Allergy & Immunology Authors: Dobbs NA, Zhou X, Pulse M, Hodge LM, Schoeb TR, Simecka JW Tags: J Immunol Source Type: research

Point-process Nonlinear Autonomic Assessment of Depressive States in Bipolar Patients.
Conclusions: A significant pattern of instantaneous heartbeat features was found in depressive and euthymic states despite the inter-subject variability. The presented point-process Heart Rate Variability (HRV) nonlinear methodology provides a promising application in the field of mood assessment in bipolar patients. PMID: 24970591 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - June 27, 2014 Category: Information Technology Authors: Valenza G, Citi L, Gentili C, Lanatá A, Scilingo EP, Barbieri R Tags: Methods Inf Med Source Type: research

Error signals as powerful stimuli for the operant conditioning-like process of the fictive respiratory output in a brainstem-spinal cord preparation from rats.
Abstract Respiratory neuromuscular activity needs to adapt to physiologic and pathologic conditions. We studied the conditioning effects of sensory fiber (putative Ia and II type from neuromuscular spindles) stimulation on the fictive respiratory output to the diaphragm, recorded from C4 phrenic ventral root, of in-vitro brainstem-spinal cord preparations from rats. The respiratory burst frequency in these preparations decreased gradually (from 0.26±0.02 to 0.09±0.003 bursts(-1)±SEM) as the age of the donor rats increased from zero to 4 days. The frequency greatly increased when the pH of the bath was lowered, a...
Source: Behavioural Brain Research - June 27, 2014 Category: Neurology Authors: Formenti A, Zocchi L Tags: Behav Brain Res Source Type: research

Transcriptional responses in the rat nasal epithelium following subchronic inhalation of naphthalene vapor.
Abstract Male and female Fischer 344 rats were exposed to naphthalene vapors at 0 (controls), 0.1, 1, 10, and 30ppm for 6h/d, 5 d/wk, over a 90-day period. Following exposure, the respiratory epithelium and olfactory epithelium from the nasal cavity were dissected separately, RNA was isolated, and gene expression microarray analysis was conducted. Only a few significant gene expression changes were observed in the olfactory or respiratory epithelium of either gender at the lowest concentration (0.1ppm). At the 1.0ppm concentration there was limited evidence of an oxidative stress response in the respiratory epithel...
Source: Toxicology and Applied Pharmacology - June 27, 2014 Category: Toxicology Authors: Clewell HJ, Efremenko A, Campbell JL, Dodd DE, Thomas RS Tags: Toxicol Appl Pharmacol Source Type: research

The effect of pre-existing medical conditions on heat stroke during hot weather in South Korea.
CONCLUSIONS: Pre-existing neuropsychiatric disorder was associated with an increased risk of heat stroke. National strategies and clinical guidance for such patients should be initiated to prevent fatal events. PMID: 24981822 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - June 27, 2014 Category: Environmental Health Authors: Kim SH, Jo SN, Myung HN, Jang JY Tags: Environ Res Source Type: research

Are children׳s asthmatic symptoms related to ambient temperature? A panel study in Australia.
CONCLUSIONS: High ambient temperature is a risk factor for respiratory symptoms in children with asthma. As ambient temperature increases, policies and strategies for rising temperatures will be necessary to protect asthmatic children. PMID: 24981821 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - June 27, 2014 Category: Environmental Health Authors: Li S, Baker PJ, Jalaludin BB, Guo Y, Marks GB, Denison LS, Williams GM Tags: Environ Res Source Type: research

Inhibition of influenza virus infection and hemagglutinin cleavage by the protease inhibitor HAI-2.
In this study, we demonstrate that HAI-2 is an effective inhibitor of cleavage of HA from the human-adapted H1 and H3 subtypes. HAI-2 inhibited influenza virus H1N1 infection in cell culture, and HAI-2 administration showed protection in a mouse model of influenza. HAI-2 has the potential to be an effective, alternative antiviral therapeutic for influenza. PMID: 24978308 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - June 27, 2014 Category: Biochemistry Authors: Hamilton BS, Chung C, Cyphers SY, Rinaldi VD, Marcano VC, Whittaker GR Tags: Biochem Biophys Res Commun Source Type: research

Association of sleep-disordered breathing with decreased cognitive function among patients with dementia.
In this study, a type-4 sleep recorder was used to evaluate respiratory function during sleep in 111 patients with dementia, and data suggesting a possible relationship with cognitive function levels were examined. Multivariate logistic regression was used to investigate the association of severity of dementia with sleep-disordered breathing, age, diabetes, dyslipidaemia and hypertension. It was found that the respiratory disturbance index was associated with severity of cognitive dysfunction in our subjects. Furthermore, patients younger than 80 years were more susceptible to lower cognitive function associated with slee...
Source: Journal of Sleep Research - June 27, 2014 Category: Sleep Medicine Authors: Aoki K, Matsuo M, Takahashi M, Murakami J, Aoki Y, Aoki N, Mizumoto H, Namikawa A, Hara H, Miyagawa M, Kadotani H, Yamada N Tags: J Sleep Res Source Type: research

Analysis of the local and systemic inflammatory response in hospitalized infants with respiratory syncitial virus bronchiolitis.
CONCLUSIONS: This study shows that RSV triggers an inflammatory response fundamentally at the respiratory level, with scant systemic repercussion. This local response is characterized by an increase in Th1 and Th2 cytokines, although with a relative predominance of Th1. The determination upon patient admission of IL-6 and MIP-1β levels in NPA, and of MIP-1β in PB could help predict severe forms and the need for oxygenotherapy. PMID: 24985791 [PubMed - as supplied by publisher] (Source: Allergologia et Immunopathologia)
Source: Allergologia et Immunopathologia - June 27, 2014 Category: Allergy & Immunology Authors: Moreno-Solís G, Torres-Borrego J, de la Torre-Aguilar MJ, Fernández-Gutiérrez F, Llorente-Cantarero FJ, Pérez-Navero JL Tags: Allergol Immunopathol (Madr) Source Type: research

Giant Thymolipoma: Case Report of an Unusual Mediastinal Tumor.
Abstract Thymolipoma is an uncommon benign neoplasm of the thymus composed of mature adipose and thymic tissue. The diagnosis of thymolipoma should be considered in the case of a mediastinal mass with fat density, especially if it is interspersed with strands of soft tissue attenuation on computed tomography scans. However, it is sometimes difficult to differentiate radiologically between a thymolipoma and other mediastinal fatty tumors. Here we present a patient with a huge mediastinal mass that proved to be a thymolipoma. PMID: 24985048 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - June 27, 2014 Category: Respiratory Medicine Authors: Obeso Carillo GA, García Fontán EM, Cañizares Carretero MA Tags: Arch Bronconeumol Source Type: research

Feasibility and Practical Considerations for Heating and Humidifying Gases during Newborn Stabilisation: An in vitro Model.
Conclusion: Rapid gas conditioning for newborn stabilisation is feasible using the experimental set-up, ≥20 ml H2O and a flow of 10 l/min. The circuit could be used immediately once switched on. Without power, conditioning is quickly lost. Investigation of the clinical effects of gas conditioning is warranted. © 2014 S. Karger AG, Basel. PMID: 24993671 [PubMed - as supplied by publisher] (Source: Neonatology)
Source: Neonatology - June 27, 2014 Category: Perinatology & Neonatology Authors: Owen LS, Dawson JA, Middleburgh R, Buttner S, McGrory L, Davis PG Tags: Neonatology Source Type: research

Excluding infection through procalcitonin testing improves outcomes of congestive heart failure patients presenting with acute respiratory symptoms: Results from the randomized ProHOSP trial
(Source: International Journal of Cardiology)
Source: International Journal of Cardiology - June 27, 2014 Category: Cardiology Authors: Philipp Schuetz, Alexander Kutz, Eva Grolimund, Sebastian Haubitz, Désirée Demann, Alaadin Vögeli, Fabienne Hitz, Mirjam Christ-Crain, Robert Thomann, Claudine Falconnier, Claus Hoess, Christoph Henzen, Robert J. Marlowe, Werner Zimmerli, Beat Mueller, Source Type: research

One Fifth of U.K. Kids with Persistent Coughs May Have Pertussis
A booster vaccination may be warranted for adolescents in England to help diminish the spread of this highly contagious respiratory disease -- Read more on ScientificAmerican.com (Source: Scientific American - Official RSS Feed)
Source: Scientific American - Official RSS Feed - June 26, 2014 Category: Science Tags: Biology Society & Policy Health Infectious Diseases Pharmaceuticals Source Type: research

Pediatric Pit Crew CPR
A reader asks, “Does your Pit Crew CPR process work for pediatrics?” See also: Pit Crew CPR – The Explicit Details The answer is, “Yes!” with some minor modifications. We are developing a class for Pediatric Pit Crew CPR. It has not yet been implemented so consider this a beta version. I hate to give a disclaimer but you should have your Medical Director review this Pediatric Pit Crew CPR concept and the accuracy of our airway chart before using it. Some things to keep in mind: Pediatric cardiac arrest is more likely to be respiratory / asphyxial so there is less emphasis on “patient&#...
Source: EMS 12-Lead - June 26, 2014 Category: Cardiology Authors: Tom Bouthillet Tags: ems-topics patient-management pediatrics Pediatric Pit Crew CPR Source Type: research

Clinical Hemodynamic Parameters Do Not Accurately Reflect Systemic Oxygen Transport in Neonates after the Norwood Procedure
ConclusionsRoutine clinical hemodynamic parameters do not accurately reflect oxygen transport after the Norwood procedure, except for SvO2, which does not differentiate between VO2 and DO2. Higher heart rate and SAP are correlated with a worse balance of oxygen transport. The results of clinical hemodynamic monitoring should be interpreted with caution. Direct measurements of oxygen transport parameters are important in the care of neonates after the Norwood procedure. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - June 26, 2014 Category: Cardiology Authors: Santokh Dhillon, Xiaoyang Yu, Gencheng Zhang, Sally Cai, Jia Li Tags: Original Article Source Type: research

Lung recruitment and endotracheal suction in ventilated preterm infants measured with electrical impedance tomography
ConclusionsETT suction in non‐muscle‐relaxed and ventilated preterm infants with RDS results in significant lung volume increase that is maintained for at least 90 min. Regional differences in distribution of ventilation with ETT suction suggest that the behaviour of the lung is heterogeneous in nature. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - June 26, 2014 Category: Pediatrics Authors: Judith L Hough, Andrew D Shearman, Helen Liley, Caroline A Grant, Andreas Schibler Tags: Original Article Source Type: research

Pseudomonas aeruginosa isolates in severe chronic obstructive pulmonary disease: characterization and risk factors
Conclusions: The main risk factors for P. aeruginosa isolation in severe COPD were the extent of bronchiectasis and exposure to antibiotics. Over 10% of these patients fulfilled criteria for chronic colonization by P. aeruginosa and showed clonal persistence, independently of the presence of bronchiectasis. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - June 26, 2014 Category: Respiratory Medicine Authors: Miguel GallegoXavier PomaresMateu EspasaEva CastañerMar SoléDavid SuárezEduard MonsóConcepción Montón Source Type: research