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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Cardiorespiratory, sedative and antinociceptive effects of dexmedetomidine alone or in combination with methadone, morphine or tramadol in dogs
Conclusions and clinical relevanceThe treatments with morphine and methadone added to the dexmedetomidine showed higher sedation scores than the control treatment and the treatment with tramadol added to the dexmedetomidine showed no relevant differences in any of the variables evaluated in the study. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - June 24, 2014 Category: Veterinary Research Authors: Clarisse G Cardoso, Danilo RC Marques, Thiago HM Silva, Ewaldo Mattos‐Junior Tags: Research Paper Source Type: research

Does off-pump coronary revascularization confer superior organ protection in re-operative coronary artery surgery? a meta-analysis of observational studies
Off-pump coronary artery bypass surgery (OPCAB) has been hypothesised to be beneficial in the high-risk patient population undergoing re-operative coronary artery bypass graft surgery (CABG). In addition, this technique has been demonstrated to provide subtle benefits in end-organ function including heart, lungs and kidney. The aims of this study were to assess whether OPCAB is associated with a lower incidence of major adverse cardiovascular and cerebrovascular events (MACCE) and other adverse outcomes in re-operative coronary surgery. Twelve studies, incorporating 3471 patients were identified by systematic literature re...
Source: Journal of Cardiothoracic Surgery - June 24, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Amir SepehripourLeanne HarlingHutan AshrafianRoberto CasulaThanos Athanasiou Source Type: research

The median effective dose of dexmedetomidine for laryngeal mask airway insertion with propofol 2.0 mg/kg
ConclusionThe single dose of dexmedetomidine for successful LMA insertion to be feasible in 50% of patients was 0.55 μg/kg during anaesthesia induction with propofol 2 mg/kg. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - June 24, 2014 Category: Anesthesiology Authors: H. J. KWAK, S. K. MIN, J. Y. YOO, K. H. PARK, J. Y. KIM Tags: Original Article Source Type: research

Miniaturized Bronchoscopy Enables for Unilateral Investigation, Application and Sampling in Mice.
Abstract Lung diseases including pneumonia and asthma are among the most prevalent human disorders, and murine models have been established to investigate their pathobiology and develop novel treatment approaches. Whereas in patients bronchoscopy is valuable for diagnostic and therapeutic procedures, no equivalent for small rodents has been established. Here we introduce a miniaturized video-bronchoscopy system offering new opportunities in experimental lung research. With an outer diameter of 0.75 mm it is possible to advance the optics into the main bronchi of mice. An irrigation channel allows bronchoalveolar la...
Source: American Journal of Respiratory Cell and Molecular Biology - June 24, 2014 Category: Molecular Biology Authors: Dames C, Akyüz L, Reppe K, Tabeling C, Dietert K, Kershaw O, Gruber AD, Meisel C, Meisel A, Witzenrath M, Engel O Tags: Am J Respir Cell Mol Biol Source Type: research

Platelet-rich-plasma Extract Prevents Pulmonary Edema through Angiopoietin-Tie2 Signaling.
Abstract Increased vascular permeability contributes to life-threatening pathological conditions, such as acute respiratory distress syndrome. Current treatments for sepsis-induced pulmonary edema rely on low-tidal volume mechanical ventilation, fluid management, and pharmacological use of a single angiogenic or chemical factor with anti-permeability activity. However, it is becoming clear that a combination of multiple angiogenic/chemical factors rather than a single factor is required for maintaining stable and functional blood vessels. We have demonstrated that mouse platelet-rich-plasma (PRP) extract contains a...
Source: American Journal of Respiratory Cell and Molecular Biology - June 24, 2014 Category: Molecular Biology Authors: Mammoto T, Jiang A, Jiang E, Mammoto A Tags: Am J Respir Cell Mol Biol Source Type: research

Eosinophil Associated Lung Diseases: a Cry for SP-A/-D Help?
Abstract Surfactant proteins (SP), namely SP-A and SP-D, play important roles in numerous eosinophil-dominated diseases, including allergic bronchopulmonary aspergillosis (ABPA), allergic rhinitis and asthma. In these settings, SPs have been shown to modulate eosinophil chemotaxis, inhibit eosinophil mediator release, and mediate macrophage clearance of apoptotic eosinophils. Dysregulation of SP function in eosinophil-dominated diseases is also not uncommon. Alterations in serum SP levels are associated with disease severity in allergic rhinitis and COPD. Furthermore, oligimerization of SP, necessary for their prop...
Source: American Journal of Respiratory Cell and Molecular Biology - June 24, 2014 Category: Molecular Biology Authors: Ledford JG, Addison KJ, Foster MW, Que LG Tags: Am J Respir Cell Mol Biol Source Type: research

Comparison of end-expiratory respiratory gating methods for PET/CT.
Conclusion. End-expiratory gating in PET/CT results in SUVmax and SUVmean increase and reduced lesion volume compared to non-gated PET and phase-gated PET. End-expiratory 4D-CTAC or averaged CTAC will offer similar accuracy for attenuation correction of end-expiratory gated PET. PMID: 24960580 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 24, 2014 Category: Cancer & Oncology Authors: Harteela M, Hirvi H, Mäkipää A, Teuho J, Koivumäki T, Mäkelä MM, Teräs M Tags: Acta Oncol Source Type: research

Clinical use of iterative 4D-cone beam computed tomography reconstructions to investigate respiratory tumor motion in lung cancer patients.
Conclusion. TV and OF iterative 4D-CBCT reconstruction of the thorax in a lung phantom and for 19 patients was demonstrated from standard CBCT scans and used to estimate the daily lung tumor motion. PMID: 24957556 [PubMed - as supplied by publisher] (Source: Acta Oncologica)
Source: Acta Oncologica - June 24, 2014 Category: Cancer & Oncology Authors: Schmidt ML, Poulsen PR, Toftegaard J, Hoffmann L, Hansen D, Sørensen TS Tags: Acta Oncol Source Type: research

Intrinsic Aerobic Capacity Impacts Susceptibility to Acute High-fat Diet-induced Hepatic Steatosis.
Conclusion: Rats bred for low intrinsic aerobic capacity show greater susceptibility for dietary-induced hepatic steatosis, which is associated with a lower energy expenditure and reduced whole-body and hepatic mitochondrial lipid oxidation. PMID: 24961240 [PubMed - as supplied by publisher] (Source: Am J Physiol Endocri...)
Source: Am J Physiol Endocri... - June 24, 2014 Category: Endocrinology Authors: Morris EM, Jackman MR, Johnson GC, Liu TW, Lopez JL, Kearney ML, Fletcher JA, Meers GM, Koch LG, Britton SL, Rector RS, Ibdah JA, MacLean PS, Thyfault JP Tags: Am J Physiol Endocrinol Metab Source Type: research

Allergic reaction to suxamethonium during emergency caesarean section and pseudocholinesterase deficiency in the same patient.
Abstract An allergic reaction during the caesarean section can be harmful for mother and foetus. Our patient has undergone an urgent caesarean section due to the imminent threat of foetal hypoxia. After operation, we applied prolonged mechanical ventilation. The anaesthesia was induced with thiopental and suxamethonium. Suxamethonium is associated with the highest incidence of allergic reactions but it is a neuromuscular blocking agent of choice for an emergency operation. During the operation, about 10 min. after induction, the systolic blood pressure dropped suddenly to 67 mmHg, the heart rate increased to 145 ...
Source: Wiener Klinische Wochenschrift - June 24, 2014 Category: Journals (General) Authors: Brozović G, Mazul Sunko B, Hafner T, Bekavac I Tags: Wien Klin Wochenschr Source Type: research

A retrospective study on the effects of pulmonary rehabilitation in patients with pulmonary hypertension.
Abstract A retrospective analysis of 23 patients was undertaken to evaluate the outcome of pulmonary rehabilitation (PR) in patients with pulmonary hypertension (PH) over a preceding 6-year time frame. Chart review and data analyses were undertaken evaluating pulmonary arterial hypertension pharmacotherapy versus the same therapy with the addition of PR. Analysis included 23 patients who had a mean pulmonary artery pressure of 36.6 while on therapy and who had initial six-minute walk tests (6MWTs) ranging between 54 and 396 meters. Outcomes included 6MWTs and Saint George's Respiratory Questionnaire. There was no i...
Source: Chronic Respiratory Disease - June 24, 2014 Category: Respiratory Medicine Authors: Raskin J, Qua D, Marks T, Sulica R Tags: Chron Respir Dis Source Type: research

Hartmannibacter diazotrophicus gen. nov., sp. nov., a novel phosphate-solubilizing and nitrogen-fixing alphaproteobacterium isolated from the rhizosphere of a natural salt meadow plant.
Abstract A phosphate-mobilizing Gram-negative bacterium was isolated from rhizospheric soil of Plantago winteri from a natural salt meadow as part of an investigation on rhizospheric bacteria from salt resistant plant species and evaluation of their plant growth-promoting abilities. Cells were rods, motile, strictly aerobic, oxidase positive and catalase negative. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain E19T was distinct from other taxa within the class Alphaproteobacteria. Strain E19T showed less than 93.5 % 16S rRNA gene sequence similarity with members of the genera Rhizobium (...
Source: International Journal of Systematic and Evolutionary Microbiology - June 24, 2014 Category: Microbiology Authors: Suarez C, Ratering S, Geissler-Plaum R, Schnell S Tags: Int J Syst Evol Microbiol Source Type: research

Airway Obstruction Caused by Penicilliosis: A Case Report and Review of the Literature.
We report the case of a 26-year-old non-HIV immunocompromised patient presenting with an airway obstruction caused by penicilliosis, together with a review of the literature of this rare condition. PMID: 24973303 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - June 24, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Boonsarngsuk V, Eksombatchai D, Kanoksil W, Tantrakul V Tags: Arch Bronconeumol Source Type: research

Reproductive, productivity, and mortality outcomes in late-gestation gilts and their litters following simulation of inadvertent exposure to a modified-live vaccine strain of porcine reproductive and respiratory syndrome (PRRS) virus.
Abstract The study evaluated the safety of a modified live-virus (MLV) porcine reproductive and respiratory syndrome (PRRS) vaccine in susceptible, pregnant gilts. To simulate inadvertent exposure secondary to postvaccination shedding of PRRS-MLV, seronegative gilts (n=51) were exposed by IM vaccination at 90 days of gestation. Vaccinated and nonvaccinated, seronegative control gilts (n=25) were maintained in separate facilities. The PRRS-MLV vaccine was given in a 2mL dose on day 0. On day 7 all vaccinated gilts were PRRSV-PCR-positive for PRRSV and had responded serologically as determined by an ELISA. All contro...
Source: Vaccine - June 24, 2014 Category: Allergy & Immunology Authors: Schelkopf A, Nerem J, Cowles B, Amodie D, Swalla R, Dee S Tags: Vaccine Source Type: research

Acute respiratory distress syndrome following verapamil overdose treated with intravenous lipid emulsion: A rare life-threatening complication.
PMID: 24972511 [PubMed - as supplied by publisher] (Source: Annales Francaises d'Anesthesie et de Reanimation)
Source: Annales Francaises d'Anesthesie et de Reanimation - June 24, 2014 Category: Anesthesiology Authors: Martin C, Gonzalez H, Ruiz S, Ribes D, Franchitto N, Minville V Tags: Ann Fr Anesth Reanim Source Type: research

Extracorporeal Membrane Oxygenation in Cardiopulmonary Disease in Adults
The use of extracorporeal membrane oxygenation (ECMO) for both respiratory and cardiac failure in adults is evolving rapidly. Advances in technology and accumulating data are spurring greater interest and explosive growth in ECMO worldwide. Expanding indications and novel strategies are being used. Yet the use of ECMO outpaces the data. The promise of a major paradigm shift for the treatment of respiratory and cardiac failure is tempered by a need for evidence to support many current and potential future uses. The authors review cannulation strategies, indications, and evidence for ECMO in respiratory and cardiac failure...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - June 23, 2014 Category: Cardiology Source Type: research

Phytochemical, Therapeutic, and Ethnopharmacological Overview for a Traditionally Important Herb: Boerhavia diffusa Linn.
Conclusions. The studies on the therapeutic activities of BD range from studies on crude extracts to isolated compounds; however some of the studies require sophistication and validated results. BD is a plant of enormous importance in the purview of its chemical and therapeutic properties. PMID: 24949473 [PubMed - as supplied by publisher] (Source: Biomed Res)
Source: Biomed Res - June 23, 2014 Category: Research Authors: Mishra S, Aeri V, Gaur PK, Jachak SM Tags: Biomed Res Int Source Type: research

Age Modulates Fe3O4 Nanoparticles Liver Toxicity: Dose-Dependent Decrease in Mitochondrial Respiratory Chain Complexes Activities and Coupling in Middle-Aged as Compared to Young Rats.
We examined the effects of iron oxide nanoparticles (IONPs) on mitochondrial respiratory chain complexes activities and mitochondrial coupling in young (3 months) and middle-aged (18 months) rat liver, organ largely involved in body iron detoxification. Isolated liver mitochondria were extracted using differential centrifugations. Maximal oxidative capacities (V max, complexes I, III, and IV activities), V succ (complexes II, III, and IV activities), and V tmpd, (complex IV activity), together with mitochondrial coupling (V max/V 0) were determined in controls conditions and after exposure to 250, 300, and 350  μ g/ml F...
Source: Biomed Res - June 23, 2014 Category: Research Authors: Baratli Y, Charles AL, Wolff V, Ben Tahar L, Smiri L, Bouitbir J, Zoll J, Sakly M, Auger C, Vogel T, Abdelmelek H, Tebourbi O, Geny B Tags: Biomed Res Int Source Type: research

A portable single‐sided magnet system for remote NMR measurements of pulmonary function
We report initial measurements from a ping‐pong ball size region in the lung as a function of lung volume. As expected, we measured decreased signal at larger lung volumes since lung density decreases with increasing lung volume. Using a CPMG sequence with ΔTE=3.5 ms and a 20 echo train, a signal to noise ratio ~1100 was obtained from an 8.8mT planar magnet after signal averaging for 43 s. This is the first demonstration of NMR measurements made on a human lung with a light‐weight planar NMR device. We argue that very low spatial resolution measurements of different lobar lung regions will provide useful diagnostic ...
Source: NMR in Biomedicine - June 23, 2014 Category: Radiology Authors: Mikayel Dabaghyan, Iga Muradyan, Alan Hrovat, James Butler, Eric Frederick, Feng Zhou, Angelos Kyriazis, Charles Hardin, Samuel Patz, Mirko Hrovat Tags: Special issue research article Source Type: research

[Newsdesk] Infectious disease surveillance update
An outbreak of parechovirus in Australia has spread to Queensland with at least 11 confirmed cases in the state up to June 4, 2014, and a total of 46 confirmed cases in the country since the outbreak began in December, 2013. The virus, which mostly affects infants, commonly causes mild respiratory or gastrointestinal symptoms, but in severe cases can develop into hepatitis or encephalitis and become fatal. The outbreak is believed to be caused by at least four types of the virus; no vaccine is available. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - June 23, 2014 Category: Infectious Diseases Authors: Nicolas Dolan Tags: Newsdesk Source Type: research

[Comment] Towards improving clinical management of Middle East respiratory syndrome coronavirus infection
A decade on from the 2002–03 outbreak of severe acute respiratory syndrome coronavirus (SARS-CoV) infections, the world is again confronted by the possible international spread of a novel coronavirus, the Middle East respiratory syndrome coronavirus (MERS-CoV), which apparently originated in the Arabian peninsula. MERS-CoV is associated with severe respiratory tract infection, often renal failure, and mortality exceeding 40% in patients admitted to hospital. Similar to SARS-CoV, it is closely related to bat coronaviruses, but MERS-CoV has different cellular receptor specificity and a broader species range—camels seem t...
Source: The Lancet Infectious Diseases - June 23, 2014 Category: Infectious Diseases Authors: Frederick G Hayden, Jeremy Farrar, J S Malik Peiris Tags: Comment Source Type: research

Automatic protective ventilation using the ARDSNet protocol with the additional monitoring of electrical impedance tomography
Conclusions: We implemented an automatic ventilation therapy using ARDSNet protocol with seven pigs. All positive outcomes were obtained by the closed-loop ventilation therapy, which can offer a continuous standard protocol-driven algorithm to ARDS subjects. (Source: Critical Care)
Source: Critical Care - June 23, 2014 Category: Intensive Care Authors: Anake PomprapaDavid SchwaibergerPhilipp PickerodtOnno TjarksBurkhard LachmannSteffen Leonhardt Source Type: research

Bronchopulmonary lophomoniasis: emerging disease or unsubstantiated legend?
The relationship between Lophomonas, a genus of multiflagellated protozoa, and respiratory pathology has recently received attention. Here, we summarize the origin, mode of transmission, pathogenic mechanism and relevant clinical data of bronchopulmonary lophomoniasis. Image: Lophomonas blattarum in a sputum smear. (Source: Parasites and Vectors)
Source: Parasites and Vectors - June 23, 2014 Category: Microbiology Authors: Rafael Martinez-GirónHugo van Woerden Source Type: research

The clinical course of recurrent respiratory papillomatosis: A comparison between aggressiveness of HPV6 and HPV11
Conclusions: Anatomically HPV11 associated RRP behaves more aggressively. Young age HPV11 and old age HPV6 patients experience a worse clinical course of RRP. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - June 23, 2014 Category: ENT & OMF Authors: Robin E.A. Tjon Pian Gi, Michel R.M. San Giorgi, Lorian Slagter‐Menkema, Bettien M. van Hemel, Bernard F.A.M. van der Laan, Edwin R. van den Heuvel, Frederik G. Dikkers, Ed Schuuring Tags: Original Article Source Type: research

Body composition markers in older persons with COPD
Conclusions: Excess body fat may be harmful for physical functioning among elders with COPD. (Source: Age and Ageing)
Source: Age and Ageing - June 23, 2014 Category: Geriatrics Authors: Abbatecola, A. M., Fumagalli, A., Spazzafumo, L., Betti, V., Misuraca, C., Corsonello, A., Cherubini, A., Guffanti, E. E., Lattanzio, F. Tags: Research Papers Source Type: research

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels
Conclusions: CFTR expression is reduced in the lungs of patients with severe COPD. This effect is associated with the accumulation of cadmium and manganese suggesting a role for these metals in the pathogenesis of COPD. (Source: Respiratory Research)
Source: Respiratory Research - June 23, 2014 Category: Respiratory Medicine Authors: Fatemat HassanXiaohua XuGerard NuovoDavid KillileaJean TyrrellChong Da TanRobert TarranPhilip DiazJunbea JeeDaren KnoellProsper BoyakaEstelle Cormet-Boyaka Source Type: research

Derivation of normative data for the COPD assessment test (CAT)
Conclusions: The characterization of CAT scores in the general population will be useful for norm-based comparisons. Longitudinal follow-up of these subjects will help in the optimization of cut-offs for the test. (Source: Respiratory Research)
Source: Respiratory Research - June 23, 2014 Category: Respiratory Medicine Authors: Lancelot PintoNisha GuptaWan TanPei LiAndrea BenedettiPaul JonesJean Bourbeau Source Type: research

CXC chemokines and antimicrobial peptides in rhinovirus‐induced experimental asthma exacerbations
ConclusionsWe propose that RV infection in asthma leads to increased release of CXCL8/IL‐8, attracting neutrophils into the airways where they release HNP 1–3, which further enhances airway neutrophilia. Strategies to inhibit CXCL8/IL‐8 may be useful in treatment of virus‐induced asthma exacerbations. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - June 23, 2014 Category: Allergy & Immunology Authors: G. Rohde, S. D. Message, J. J. Haas, T. Kebadze, H. Parker, V. Laza‐Stanca, M. R. Khaitov, O. M. Kon, L. A. Stanciu, P. Mallia, M. R. Edwards, S. L. Johnston Tags: Original Article Source Type: research

Mucosal Polyinosinic-Polycytidylic Acid Improves Protection Elicited by Replicating Influenza Vaccines via Enhanced Dendritic Cell Function and T Cell Immunity.
In this study, we assessed the effect of the TLR3 ligand polyinosinic-polycytidylic acid (poly IC) on CD8 T cell immunity and protection elicited by LAIVs. Mucosal treatment with poly IC shortly after vaccination enhanced respiratory dendritic cell function, CD8 T cell formation, and production of neutralizing Abs. This adjuvant effect of poly IC was dependent on amplification of TLR3 signaling by nonhematopoietic radioresistant cells and enhanced mouse protection to homosubtypic, as well as heterosubtypic, virus challenge. Our findings indicate that mucosal TLR3 ligation may be used to improve CD8 T cell responses to repl...
Source: Journal of Immunology - June 23, 2014 Category: Allergy & Immunology Authors: Pérez-Girón JV, Belicha-Villanueva A, Hassan E, Gómez-Medina S, Cruz JL, Lüdtke A, Ruibal P, Albrecht RA, García-Sastre A, Muñoz-Fontela C Tags: J Immunol Source Type: research

Pneumonia, thrombosis and vascular disease.
This article is protected by copyright. All rights reserved. PMID: 24954194 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - June 23, 2014 Category: Hematology Authors: Violi F, Cangemi R, Calvieri C Tags: J Thromb Haemost Source Type: research

Is Chronic Asthma Associated with Shorter Leukocyte Telomere Length at Midlife?
Conclusions. Life-course-persistent asthma is related to a proposed biomarker of accelerated aging, possibly via systemic eosinophilic inflammation. Life histories of asthma can inform studies of aging. PMID: 24956257 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 23, 2014 Category: Respiratory Medicine Authors: Belsky DW, Shalev I, Sears MR, Hancox RJ, Harrington H, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A Tags: Am J Respir Crit Care Med Source Type: research

Gender-dependent Influence of Endogenous Estrogen in Pulmonary Hypertension.
Conclusions: The unique phenotype of female pulmonary arteries facilitates the therapeutic effects of anastrozole in experimental PH confirming a role for endogenous estrogen in the disease pathogenesis in females and suggests aromatase inhibitors may have therapeutic potential. PMID: 24956156 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 23, 2014 Category: Respiratory Medicine Authors: Mair KM, Wright AF, Duggan N, Rowlands DJ, Hussey MJ, Roberts S, Fullerton J, Nilsen M, Loughlin L, Thomas M, MacLean MR Tags: Am J Respir Crit Care Med Source Type: research

Fine particulate matter air pollution and blood pressure: The modifying role of psychosocial stress.
CONCLUSIONS: These results suggest that psychosocial stress may increase vulnerability to the hypertensive effects of PM2.5. This work contributes to an understanding of the ways in which the social and physical environments may jointly contribute to poor health and to health disparities. PMID: 24968081 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - June 23, 2014 Category: Environmental Health Authors: Hicken MT, Dvonch JT, Schulz AJ, Mentz G, Max P Tags: Environ Res Source Type: research

Oligochitosan stimulated phagocytic activity of macrophages from blunt snout bream (Megalobrama amblycephala) associated with respiratory burst coupled with nitric oxide production.
In conclusion, the stimulation effects of oligochitosan on the phagocytic activity of the fish macrophages were associated with respiratory burst coupled with nitric oxide production. PMID: 24968077 [PubMed - as supplied by publisher] (Source: Developmental and Comparative Immunology)
Source: Developmental and Comparative Immunology - June 23, 2014 Category: Allergy & Immunology Authors: Liu L, Zhou Y, Zhao X, Wang H, Wang L, Yuan G, Asim M, Wang W, Zeng L, Liu X, Lin L Tags: Dev Comp Immunol Source Type: research

Mitochondrial DNA depletion in single fibers in a patient with novel TK2 mutations
We describe a patient with progressive muscle weakness and increased creatine kinase and lactate levels. Muscle weakness was first noted at age 1.5years and he died of respiratory failure and bronchopneumonia at age 3.5years. The muscle biopsy showed dystrophic features with ragged red fibers and numerous cytochrome c oxidase (COX)-negative fibers. qPCR analysis demonstrated depletion of mtDNA and sequence analysis of the mitochondrial thymidine kinase 2 (TK2) gene revealed two novel heterozygous variants, c.332C>T, p.(T111I) and c.156+5G>C. Quantitative analysis of mtDNA in single muscle fibers demonstrated that COX-defic...
Source: Neuromuscular Disorders - June 23, 2014 Category: Neurology Authors: S. Roos, U. Lindgren, C. Ehrstedt, A.R. Moslemi, A. Oldfors Tags: Research papers Source Type: research

Distal myosin heavy chain-7 myopathy due to the novel transition c.5566G>A (p.E1856K) with high interfamilial cardiac variability and putative anticipation
Abstract: Myosin-heavy-chain 7 (MYH7)-myopathy manifests clinically with a distal, scapuloperoneal, limb-girdle (proximal), or axial distribution and may involve the respiratory muscles. Cardiac involvement is frequent, ranging from relaxation impairment to severe dilative cardiomyopathy. Progression and earlier onset of cardiac disease in successive generations with MYH7-myopathy is unreported. In a five-generation family MYH7-myopathy due to the novel c.5566G>A (p.E1856K) mutation manifested with late-onset, distal>proximal myopathy and variable degree of cardiac involvement. The index patient developed distal myopathy s...
Source: Neuromuscular Disorders - June 23, 2014 Category: Neurology Authors: Josef Finsterer, Oliver Brandau, Claudia Stöllberger, William Wallefeld, Nigel G. Laing, Franco Laccone Tags: Research papers Source Type: research

Sevoflurane in combination with remifentanil for tracheal extubation after otologic surgery.
CONCLUSION: Sevoflurane combined with remifentanil provided rapid recovery and appeared to be safe for deep-anesthesia tracheal extubation in adult patients after otologic surgery. PMID: 24939489 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - June 22, 2014 Category: Drugs & Pharmacology Authors: Hu C, Yu H, Ye M, Shen X Tags: Am J Health Syst Pharm Source Type: research

Constitutive Activity of Bitter Taste Receptors (T2Rs).
Abstract G protein-coupled receptors (GPCRs) play a vital role in transmitting an extracellular stimuli or signal into an intracellular response in various cells. In some scenarios, GPCRs or their mutants can also signal in the absence of an agonist or an external stimulus, referred to as basal or constitutive activity, and those mutants are termed constitutively active mutants (CAMs). Bitter taste is one of the five basic tastes and is mediated by bitter taste receptors (T2Rs), which belong to the GPCR superfamily. The 25 T2Rs present in humans do not belong to any of the major GPCR classes, and their classificati...
Source: Advances in Pharmacology - June 22, 2014 Category: Drugs & Pharmacology Authors: Pydi SP, Bhullar RP, Chelikani P Tags: Adv Pharmacol Source Type: research

Idiopathic desquamative interstitial pneumonia in a child: a case report
Conclusion: We believe that desquamative interstitial pneumonia is not always associated with mutations of the surfactant proteins, and can still be idiopathic, especially when occurring as part of a syndrome with multiple organ involvement, as described in other interstitial lung diseases. (Source: BMC Research Notes)
Source: BMC Research Notes - June 22, 2014 Category: Research Authors: Sabrina Bressieux-DegueldreSamuel RotmanGaudenz HafenJohn-David AubertIsabelle Rochat Source Type: research

Marinomonas profundimaris sp. nov., isolated from deep-sea sediment sample of the Arctic Ocean.
Abstract A taxonomic study was carried out on strain D104(T), which was isolated from deep-sea subsurface sediment sample from the Arctic Ocean. The bacterium was found to be Gram-negative, oxidase negative and catalase weakly positive, rod shaped, motile by means of polar flagellum. The organism grows between 4 and 37 °C (optimum 25-28 °C) and 0.5-6 % NaCl (optimum 3 %). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain D104(T) belongs to the genus Marinomonas, with highest sequence similarities of 97.7 % to Marinomonas ushuaiensis DSM 15871(T), followed by M. dokdonensis DSW10-10...
Source: Antonie van Leeuwenhoek - June 22, 2014 Category: Microbiology Authors: Bai X, Lai Q, Dong C, Li F, Shao Z Tags: Antonie Van Leeuwenhoek Source Type: research

Pre‐ and postnatal exposure to tobacco smoke and respiratory outcomes during the first year
Abstract The different role of prenatal and postnatal exposure to tobacco smoke in respiratory outcomes in infants has not yet been clearly established. Our objective is to assess the effects of these exposures on the risk of respiratory outcomes during the first year of life of infants from a Spanish multicenter cohort study. A total of 2506 women were monitored until delivery. About 2039 infants made up the final population. The outcomes were caused by the occurrence of the following: otitis, cough persisting for more than 3 weeks, lower respiratory tract symptoms (wheezing or chestiness), and lower respiratory tract in...
Source: Indoor Air - June 21, 2014 Category: Occupational Health Authors: V. Fuentes‐Leonarte, M. Estarlich, F. Ballester, M. Murcia, A. Esplugues, J. J. Aurrekoetxea, M. Basterrechea, A. Fernández‐Somoano, E. Morales, M. Gascón, A. Tardón, M. Rebagliato Tags: Original Article Source Type: research

Acute respiratory distress in a silversmith
Jignesh Mukeshkumar Parikh, Shashank Dhareshwar, Anand Sharma, Raghuveer Karanth, V. S. Ramkumar, Indira RamaiahIndian Journal of Occupational and Environmental Medicine 2014 18(1):27-28A 25-year-old young male patient presented in casualty department with severe respiratory distress on the fourth day from onset of symptoms. The patient was nonsmoker and had no antecedent medical or drug history. Prior to admission, patient had dry cough and bilateral pleuritic chest pain for the last three days. He was in severe respiratory distress with use of accessory muscles of respiration. On examination, he had heart rate of 120 bea...
Source: Indian Journal of Occupational and Environmental Medicine - June 21, 2014 Category: Occupational Health Authors: Jignesh Mukeshkumar ParikhShashank DhareshwarAnand SharmaRaghuveer KaranthV. S. RamkumarIndira Ramaiah Source Type: research

Bi-level cpap does not change central blood flow in preterm infants with respiratory distress syndrome
Conclusions: Central blood flow doesn't change during bi-level CPAP support, which could become a hemodinamically safe tool for the treatment of RDS in preterm infants. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - June 21, 2014 Category: Pediatrics Authors: Giulia AquilanoSilvia GallettiArianna AcetiFrancesca VitaliGiacomo Faldella Source Type: research

A model of human nasal epithelial cells adapted for direct and repeated exposure to airborne pollutants.
Abstract Airway epithelium lining the nasal cavity plays a pivotal role in respiratory tract defense and protection mechanisms. Air pollution induces alterations linked to airway diseases such as asthma. Only very few in vitro studies to date have succeeded in reproducing physiological conditions relevant to cellular type and chronic atmospheric pollution exposure. We therefore, set up an in vitro model of human Airway Epithelial Cells of Nasal origin (hAECN) close to real human cell functionality, specifically adapted to study the biological effects of exposure to indoor gaseous pollution at the environmental leve...
Source: Toxicology Letters - June 21, 2014 Category: Toxicology Authors: Bardet G, Achard S, Loret T, Desauziers V, Momas I, Seta N Tags: Toxicol Lett Source Type: research

Medical, psychological and social features in a large cohort of adults with Prader–Willi syndrome: experience from a dedicated centre in France
ConclusionsAdult patients with PWS showed high prevalence of comorbid health problems that need to be monitored for early treatment. Some of them are influenced by genotype and age. Another salient problem concerns the lack of adapted structures for better social integration. Further data about the real life and health conditions of adults with PWS are necessary to further our knowledge of the natural history of the disease and to design appropriate care strategies. (Source: Journal of Intellectual Disability Research)
Source: Journal of Intellectual Disability Research - June 20, 2014 Category: Disability Authors: V. Laurier, A. Lapeyrade, P. Copet, G. Demeer, M. Silvie, E. Bieth, M. Coupaye, C. Poitou, F. Lorenzini, F. Labrousse, C. Molinas, M. Tauber, D. Thuilleaux, J. Jauregi Tags: Original Article Source Type: research