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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 18.

Grass pollen allergens globally; the contribution of subtropical grasses to burden of allergic respiratory diseases
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - March 30, 2014 Category: Allergy & Immunology Authors: Janet M Davies Tags: Invited Review Source Type: research

Ciliary Neurotrophic Factor Reverses Aberrant Mitochondrial Bioenergetics Through the JAK/STAT Pathway in Cultured Sensory Neurons Derived from Streptozotocin-Induced Diabetic Rodents.
Abstract Mitochondrial dysfunction occurs in sensory neurons and contributes to diabetic neuropathy. Ciliary neurotrophic factor (CNTF) stimulates axon regeneration in type 1 diabetic rodents and prevents deficits in axonal caliber, nerve conduction, and thermal sensation. We tested the hypothesis that CNTF enhances sensory neuron function in diabetes through JAK/STAT (Janus kinase/signal transducers and activators of transcription) signaling to normalize impaired mitochondrial bioenergetics. The effect of CNTF on gene expression and neurite outgrowth of cultured adult dorsal root ganglia (DRG) sensory neurons deri...
Source: Cellular and Molecular Neurobiology - March 30, 2014 Category: Cytology Authors: Chowdhury SR, Saleh A, Akude E, Smith DR, Morrow D, Tessler L, Calcutt NA, Fernyhough P Tags: Cell Mol Neurobiol Source Type: research

Pulmonary complications of connective tissue disease.
PMID: 24668531 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Antin-Ozerkis D, Swigris J Tags: Semin Respir Crit Care Med Source Type: research

High-resolution computed tomography of the pulmonary manifestations of connective tissue diseases.
Abstract Pulmonary disease is common in patients with connective tissue disease (CTD) and confers significant morbidity and mortality. High-resolution computed tomography (HRCT) provides considerable information regarding the distribution and severity of thoracic disease in CTD. Different anatomical compartments of the lung can be simultaneously affected in a given individual. Furthermore, lung injury may not be solely related to the underlying CTD, but may be caused by treatment or infections. Finally, the risk of developing cancer is increased in patients with certain CTDs. In this review, the HRCT manifestations...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Jacob J, Nair A, Hansell DM Tags: Semin Respir Crit Care Med Source Type: research

Cross-disciplinary collaboration in connective tissue disease-related lung disease.
Abstract Lung disease is a common manifestation of connective tissue disease (CTD) and is associated with significant morbidity and mortality. The evaluation of lung disease, and interstitial lung disease (ILD) in particular, in patients with CTD is complex because of the heterogeneity of the CTDs, the varied types and degrees of severity of ILD encountered, and because ILD can be identified at any point in time in these patients. Cross-disciplinary, thorough evaluations are needed when CTD patients develop ILD or when evaluating ILD patients for the presence of occult CTD. Determining that ILD is associated with a...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Fischer A, Richeldi L Tags: Semin Respir Crit Care Med Source Type: research

Interstitial lung disease in systemic sclerosis.
Abstract Despite many unanswered questions regarding the pathogenesis of interstitial lung disease in systemic sclerosis (SSc-ILD) and the lack of accurate epidemiological risk factors, there have been major advances in the identification and prognostic evaluation of SSc-ILD. The evaluation of disease severity is a multidisciplinary exercise, requiring the integration of pulmonary function tests, high-resolution computed tomography data, and symptomatic severity and these factors all need to be considered in the detection of disease progression. Except in a minority of patients with reversible inflammatory disease,...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Wells AU, Margaritopoulos GA, Antoniou KM, Denton C Tags: Semin Respir Crit Care Med Source Type: research

Pulmonary pathology in connective tissue disease.
Abstract A significant proportion of patients with autoimmune connective tissue disease (CTD) show lung involvement that results in clinical interstitial lung disease (ILD). Surgical lung biopsy is helpful for diagnosis of CTD-ILD in many cases. In this review, we discuss the histologic manifestations of different types of CTD-ILD, focusing on patterns of disease and their differential diagnoses. Acquired autoimmune connective tissue diseases will be covered in this review, while lung involvement in vasculitides, heritable connective tissue disorders, and drug-induced CTD-like conditions will not be discussed. ...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Urisman A, Jones KD Tags: Semin Respir Crit Care Med Source Type: research

Biomarkers in connective tissue disease-associated interstitial lung disease.
This article reviews major biomarkers in serum and bronchoalveolar lavage fluid (BALF) with respect to their diagnostic and prognostic value in connective tissue disease-associated interstitial lung disease (CTD-ILD). In some CTD such as systemic sclerosis (SSc), the incidence of ILD is up to two-third of patients, and currently ILD represents the leading cause of death in SSc. Because of the extremely variable incidence and outcome of ILD in CTD, progress in the discovery and validation of biomarkers for diagnosis, prognosis, patients' subtyping, response to treatment, or as surrogate endpoints in clinical trials is extre...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Bonella F, Costabel U Tags: Semin Respir Crit Care Med Source Type: research

Pulmonary manifestations of systemic lupus erythematosus.
Abstract Systemic lupus erythematosus (SLE) is a systemic inflammatory disease, characterized serologically by an autoantibody response to nucleic antigens, and clinically by injury and/or malfunction in any organ system. During their disease course, up to 50% of SLE patients will develop lung disease. Pulmonary manifestations of SLE include pleuritis (with or without effusion), inflammatory and fibrotic forms of interstitial lung disease, alveolar hemorrhage, shrinking lung syndrome, pulmonary hypertension, airways disease, and thromboembolic disease. Two major themes inform our understanding of SLE-associated pul...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Mittoo S, Fell CD Tags: Semin Respir Crit Care Med Source Type: research

Pulmonary manifestations of polymyositis/dermatomyositis.
Abstract The idiopathic inflammatory myopathies are a group of connective tissue diseases marked by varying degrees of muscle inflammation and clinical involvement of multiple organs, most notably, the lung. Pulmonary manifestations consist primarily of interstitial lung disease (ILD), which is associated with significant morbidity and mortality in myositis patients. Several myositis-specific antibodies have been discovered, as well as antibodies targeting various aminoacyl-tRNA synthetase enzymes. These antibodies are associated with various clinical features and a risk for developing ILD, and their presence carri...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Hallowell RW, Ascherman DP, Danoff SK Tags: Semin Respir Crit Care Med Source Type: research

Rheumatoid arthritis and lung disease: from mechanisms to a practical approach.
Abstract Rheumatoid arthritis (RA) is a common chronic systemic autoimmune disease characterized by joint inflammation and, in a proportion of patients, extra-articular manifestations (EAM). Lung disease, either as an EAM of the disease, related to the drug therapy for RA, or related to comorbid conditions, is the second commonest cause of mortality. All areas of the lung including the pleura, airways, parenchyma, and vasculature may be involved, with interstitial and pleural disease and infection being the most common problems. High-resolution computed tomography of the chest forms the basis of investigation and w...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Lake F, Proudman S Tags: Semin Respir Crit Care Med Source Type: research

The use of high-flow nasal oxygen therapy in the management of hypercarbic respiratory failure.
Abstract Hypercarbic respiratory failure, occurring secondary to chronic lung disease, is a frequently encountered problem. These patients present a significant challenge to respiratory and critical care services, as many are unsuitable for mechanical ventilation and most have multiple comorbidities. Recently, noninvasive ventilation (NIV) has become established as the primary modality for respiratory support in this group of patients. Several factors limit patient compliance with NIV, not least comfort and tolerability. A recent innovation in adult critical care is the use of high-flow nasal oxygen (HFNO) devices....
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Millar J, Lutton S, O'Connor P Tags: Ther Adv Respir Dis Source Type: research

Adjunctive drug therapies for treatment of respiratory diseases in the newborn: based on evidence or habit?
Abstract Respiratory distress syndrome is a disease of prematurity and is caused by a relative deficiency of endogenous surfactant production. Respiratory distress syndrome is the most common cause of mortality and morbidity in the newborn population and the standard of care is to provide exogenous surfactant therapy. This saves lives and reduces respiratory complications but, despite treatment, a significant proportion of these infants go onto develop chronic lung disease, the severest form of which is bronchopulmonary dysplasia. Once developed, this is a multisystem disease and treatment is mostly supportive by u...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Sinha S, Tin W Tags: Ther Adv Respir Dis Source Type: research

Supportive care for patients with pulmonary complications of connective tissue disease.
This article addresses supportive measures such as supplemental oxygen and pulmonary rehabilitation. Issues related to quality of life, sleep disturbances, and identification of mood disorders are discussed. In addition, we review significant comorbidities, including cardiovascular disease, glucocorticoid-induced osteoporosis, and gastroesophageal reflux disease. Essential facets of advanced lung disease, including mechanical ventilation, lung transplantation, end-of-life care, and hospice, are covered. PMID: 24668542 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Gulati M, Antin-Ozerkis D Tags: Semin Respir Crit Care Med Source Type: research

Immunosuppression for connective tissue disease-related pulmonary disease.
This article examines the data underpinning the use of different immunosuppressants in CTD-associated pulmonary disease while highlighting limitations in the existing knowledge base and identifying questions for future clinical study. PMID: 24668541 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Maher TM Tags: Semin Respir Crit Care Med Source Type: research

Pulmonary involvement in sjögren syndrome.
Abstract Sjögren syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic inflammation of exocrine glands and a variety of extraglandular sites. Lung involvement as defined by symptoms and either pulmonary function testing or radiographic abnormalities occurs in approximately 10 to 20% of patients. Subclinical lung disease is even more frequent and often includes evidence of small airways disease and airway inflammation. In general, patients will have evidence of both airway and interstitial lung disease by radiographs and pathology. Bronchiolitis and bronchiectasis are the most common airway man...
Source: Respiratory Care - March 29, 2014 Category: Respiratory Medicine Authors: Kreider M, Highland K Tags: Semin Respir Crit Care Med Source Type: research

Otological findings in pediatric patients with hypogammaglobulinemia.
This study was designed to investigate clinical and paraclinical otological complications in major types of PAD. A cross sectional study was conducted on 55 PAD patients with diagnosis of selective IgA deficiency, common variable immunodeficiency (CVID), X-linked agammaglobulinemia (XLA), and hyper IgM syndrome. All patients underwent otological examinations, audiometry, and auditory brain stem response. Otological complications were detected in 54.5% of PAD patients. Conductive hearing loss was the main finding amongst PID patients (73.3%) followed by sensorineural hearing loss which was present in 8 cases. Otitis media w...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Tavakol M, Kouhi A, Abolhassani H, Ghajar A, Afarideh M, Shahinpour S, Aghamohammadi A Tags: Iran J Allergy Asthma Immunol Source Type: research

Oleaceae pollen allergy and its cross-reactivity in the mediterranean area in the context of globalization.
Abstract Opening frontiers has led in the last two decades to a massive migration of Romanians to Spain and Italy, two countries known to have large areas planted with olives. Romania owns large areas planted with ash forests. Because of cross-reactivity between these two trees belonging to the Oleaceae family and the big allergenic potential of olive pollens, after a number of years of residence in these countries, many Romanians will present allergic respiratory symptoms of rhinitis and asthma, both in the season of olive pollination and ash pollination. PMID: 24659166 [PubMed - in process] (Source: Iranian ...
Source: Iranian Journal of Allergy, Asthma and Immunology - March 29, 2014 Category: Allergy & Immunology Authors: Berghi NO Tags: Iran J Allergy Asthma Immunol Source Type: research

Distinct regulation of tonsillar immune response in virus infection
ConclusionsTonsillar cytokine expression is closely related to existing viral infections, age, and allergic illnesses and shows distinct clusters between antiviral and immune regulatory genes. (Source: Allergy)
Source: Allergy - March 29, 2014 Category: Allergy & Immunology Authors: T. Jartti, O. Palomares, M. Waris, O. Tastan, R. Nieminen, T. Puhakka, B. Rückert, A. Aab, T. Vuorinen, T. Allander, T. Vahlberg, O. Ruuskanen, M. Akdis, C. A. Akdis Tags: Original Article Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 29, 2014 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Subglosso-palatal membrane a rare cause of neonatal respiratory distress: A case report
Vaibhav Pandey, Preeti Tiwari, Jayanto Tapadar, Ajay Narayan GangopadhyayJournal of Indian Association of Pediatric Surgeons 2014 19(2):109-111Subglosso-palatal membrane is a rare cause of acute respiratory distress in newborn. Contrary to the earlier reported cases in which immediate splitting or excision of membrane has been described as measure to relief respiratory distress, we managed our case successfully without any emergency surgical procedure. (Source: Journal of Indian Association of Pediatric Surgeons)
Source: Journal of Indian Association of Pediatric Surgeons - March 29, 2014 Category: Surgery Authors: Vaibhav PandeyPreeti TiwariJayanto TapadarAjay Narayan Gangopadhyay Source Type: research

The effectiveness of the quality program Pac-IficO to improve pain management in hospitalized cancer patients: a before-after cluster phase II trial
The objective of the study is to evaluate the efficacy of the Pac-IFicO programme in improving the quality of pain management in hospitalised cancer patients. Methods: This is a before-after cluster phase II study. After the before assessment, the experimental intervention - the Pac-IFicO programme - will be implemented in ten medicine, oncology and respiratory disease hospital wards. The same assessment will be repeated after the completion of the intervention. The Pac-IFicO programme is a complex intervention with multiple components. It includes focus group with ward professionals for identifying possible local obstacle...
Source: BMC Palliative Care - Latest articles - March 29, 2014 Category: Palliative Care Authors: Carla RipamontiCesarina PrandiMassimo CostantiniElisa PerfettiFabio PellegriniMarco VisentinLorenza GarrinoAnna De LucaMaria PessiCarlo Peruselli Source Type: research

Nanocarriers for Respiratory Diseases Treatment: Recent Advances and Current Challenges.
Abstract Pulmonary delivery of locally-acting drugs encapsulated in nanocarriers provides several advantages for the treatment of respiratory diseases as asthma, chronic obstructive pulmonary diseases, cystic fibrosis, tuberculosis and lung cancer. These advantages include, among others, sustained drug delivery to the lungs, reduced therapeutic dose and improved patient compliance. The aim of this review is to give an up-dated overview on recent advances recorded in the last few years in this field as well as on the major challenges still existing and that remain to be overcome before any clinical application. Afte...
Source: Current Topics in Medicinal Chemistry - March 29, 2014 Category: Chemistry Authors: Trapani A, Gioia SD, Castellani S, Carbone A, Cavallaro G, Trapani G, Conese M Tags: Curr Top Med Chem Source Type: research

Intranasally administered Endocine™ formulated 2009 pandemic influenza H1N1 vaccine induces broad specific antibody responses and confers protection in ferrets.
Abstract Influenza is a contagious respiratory disease caused by an influenza virus. Due to continuous antigenic drift of seasonal influenza viruses, influenza vaccines need to be adjusted before every influenza season. This allows annual vaccination with multivalent seasonal influenza vaccines, recommended especially for high-risk groups. There is a need for a seasonal influenza vaccine that induces broader and longer lasting protection upon easy administration. Endocine™ is a lipid-based mucosal adjuvant composed of endogenous lipids found ubiquitously in the human body. Intranasal administration of influenza a...
Source: Vaccine - March 29, 2014 Category: Allergy & Immunology Authors: Maltais AK, Stittelaar KJ, Kroeze EJ, van Amerongen G, Dijkshoorn ML, Krestin GP, Hinkula J, Arwidsson H, Lindberg A, Osterhaus AD Tags: Vaccine Source Type: research

Selenium deficiency and the effects of supplementation on preterm infants
Conclusions: Prematurity and low birth weight can contribute to low blood selenium in premature infants. Selenium supplementation seems to minimize or prevent clinical complications caused by prematurity. RESUMEN Objetivo: Revisar los trabajos que analizaron las concentraciones sanguíneas de selenio asociadas con la edad gestacional, alimentación, suplementación y cuadro clínico de prematuros. Fuentes de datos : Revisión sistemática de la literatura mediante búsquedas electrónicas en las bases de datos a continuación: Medline Pubmed, Google académico, SciELO. org, SienceDirect (Elsevier) y CINAHL with Full Tex...
Source: Revista Paulista de Pediatria - March 28, 2014 Category: Pediatrics Source Type: research

Effectiveness of an outpatient preoperative care bundle in preventing postoperative pneumonia among esophageal cancer patients
Conclusion: Implementation of the procedures of the preoperative care bundle was shown to be effective for preventing postoperative pneumonia in patients with esophageal cancer. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - March 28, 2014 Category: Infectious Diseases Authors: Tamae Hiramatsu, Makiko Sugiyama, Setsuko Kuwabara, Yuji Tachimori, Midori Nishioka Tags: Major Articles Source Type: research

Major biologic characteristics of Acinetobacter baumannii isolates from hospital environmental and patients' respiratory tract sources
Conclusions: This study demonstrates that A baumannii isolates from the patients' respiratory tract and hospital environment carried much similar multidrug resistance patterns and biologic characteristics. In conclusion, this study shows that all MDR A baumannii strains survived well in the hospital environment, especially in water and moist environment and produced biofilm, which might be responsible for high colonization in the respiratory tract of patients in ICU. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - March 28, 2014 Category: Infectious Diseases Authors: Nathir Obeidat, Fatin Jawdat, Amal G. Al-Bakri, Asem A. Shehabi Tags: Major Articles Source Type: research

Association of abdominal obesity in children with perioperative respiratory adverse events.
CONCLUSION: WC, a measure of abdominal obesity, is an independent predictor of perioperative respiratory adverse events in children undergoing elective noncardiac surgery. Furthermore, abdominal obesity was associated with prolonged PACU length of stay. PMID: 24661478 [PubMed - in process] (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - March 28, 2014 Category: Nursing Authors: Nafiu OO, Onyewuche V Tags: J Perianesth Nurs Source Type: research

Enzyme replacement therapy for Mucopolysaccharidosis Type I among patients followed within the MPS Brazil Network
Mucopolysaccharidosis type I (MPS I) is a rare lysosomal disorder caused by deficiency of alph-L-iduronidase. Few clinical trials have assessed the effect of enzyme replacement therapy (ERT) for this condition. We conducted an exploratory, open-label, non-randomized, multicenter cohort study of patients with MPS I. Data were collected from questionnaires completed by attending physicians at the time of diagnosis (T1; n = 34) and at a median time of 2.5 years later (T2; n = 24/34). The 24 patients for whom data were available at T2 were allocated into groups: A, no ERT (9 patients; median age at T1 = 36 months; 6 with sever...
Source: Genetics and Molecular Biology - March 28, 2014 Category: Genetics & Stem Cells Source Type: research

Physiological Consequences of Rapid or Prolonged Aircraft Decompression: Evaluation Using a Human Respiratory Model
(Source: Aviation, Space, and Environmental Medicine)
Source: Aviation, Space, and Environmental Medicine - March 28, 2014 Category: Sports Medicine Authors: Wolf, Matthew Tags: TECHNICAL NOTES Source Type: research

Glucose tolerance affects pubertal growth and final height of children with cystic fibrosis
Summary There are few data about the impact of cystic fibrosis‐related diabetes (CFRD) on growth. We analyzed 17 children with cystic fibrosis (CF) presenting with newly diagnosed CFRD during puberty, in comparison with a matched control group of 52 CF children with normal glucose tolerance (NGT). Anthropometric evaluation showed that body mass index at CFRD diagnosis was significantly reduced in children with CFRD, in comparison with children with NGT (CFRD: −0.48 ± 1.08 vs. NGT: 0.2 ± 0.99; P = 0.01), and the same difference remained evident at the end of follow up (CFRD: −0.49 ± 0.95 vs. NGT: 0....
Source: Pediatric Pulmonology - March 28, 2014 Category: Respiratory Medicine Authors: Carla Bizzarri, Enza Montemitro, Stefania Pedicelli, Sara Ciccone, Fabio Majo, Marco Cappa, Vincenzina Lucidi Tags: Original Article: Cystic Fibrosis Source Type: research

Study seeks a better look inside the brain
Right now there’s only one way to determine if someone has fully recovered from a concussion: ask them how they feel. If the patient says “fine,” he or she is considered healed. There is no objective way to determine how much the brain has been injured and affected because of a concussion, and no way to accurately measure where the patient is in the healing process. But researchers at the Lovealce Respiratory Research Institute and the Mind Research Network are working to change that. For… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 28, 2014 Category: American Health Authors: Dennis Domrzalski Source Type: research

Exposure to traffic and early life respiratory infection: A cohort study
We examined whether proximity to a major roadway and traffic density around the home during pregnancy are associated with risk of early life respiratory infection in a pre‐birth cohort in the Boston area. We geocoded addresses for 1,263 mother‐child pairs enrolled during the first trimester of pregnancy in Project Viva during 1999–2002. We calculated distance from home to nearest major roadway and traffic density in a 100 m buffer around the home. We defined respiratory infection as maternal report of ≥1 doctor‐diagnosed pneumonia, bronchiolitis, croup, or other respiratory infection from birth until the early ...
Source: Pediatric Pulmonology - March 28, 2014 Category: Respiratory Medicine Authors: Mary B. Rice, Sheryl L. Rifas‐Shiman, Emily Oken, Matthew W. Gillman, Petter L. Ljungman, Augusto A. Litonjua, Joel Schwartz, Brent A. Coull, Antonella Zanobetti, Petros Koutrakis, Steven J. Melly, Murray A. Mittleman, Diane R. Gold Tags: Original Article: Epidemilogy Source Type: research

Comparison of the modified shuttle walk test and cardiopulmonary exercise test in sarcoidosis
ConclusionsPeak VO2 achieved during CPET strongly correlated with MSWT distance. MSWT is a measure of peak exercise capacity in sarcoidosis that does not require equipment and can be readily available in the clinic. (Source: Respirology)
Source: Respirology - March 28, 2014 Category: Respiratory Medicine Authors: Sally Boer, John Kolbe, Margaret L. Wilsher Tags: Original Article Source Type: research

Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria
Conclusion: The results are consistent with multiple pathogenic mechanisms leading to severe malaria and heterogeneity in the pathophysiology of impaired consciousness. The observed association between group A-like PfEMP1 and impaired consciousness does not appear to involve widespread endothelial activation. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - March 28, 2014 Category: Infectious Diseases Authors: Abdirahman AbdiGregory FeganMichelle MuthuiEsther KiraguJennifer MusyokiMichael OpiyoKevin MarshGeorge WarimwePeter Bull Source Type: research