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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Corticosteroids in the treatment of acute asthma
Abdullah A AlangariAnnals of Thoracic Medicine 2014 9(4):187-192Asthma is a prevalent chronic disease of the respiratory system and acute asthma exacerbations are among the most common causes of presentation to the emergency department (ED) and admission to hospital particularly in children. Bronchial airways inflammation is the most prominent pathological feature of asthma. Inhaled corticosteroids (ICS), through their anti-inflammatory effects have been the mainstay of treatment of asthma for many years. Systemic and ICS are also used in the treatment of acute asthma exacerbations. Several international asthma management ...
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Abdullah A Alangari Source Type: research

Pictorial review of intrathoracic manifestations of progressive systemic sclerosis
Hamdan AL-Jahdali, Prabhakar Rajiah, Carolyn Allen, Shyam Sunder Koteyar, Ali Nawaz KhanAnnals of Thoracic Medicine 2014 9(4):193-202Intra-thoracic manifestations of progressive systemic sclerosis (PSS) are not well known particularly the imaging features, which forms the basis of accurate and timely diagnosis. The aim of this study is to familiarize the physicians and radiologists with these features. The diagnosis can remain elusive because of the non-specific nature of symptoms which mimic many common conditions. Thus, the diagnosis of PSS can be missed leading to continuous morbidity if the correct imaging is not pursu...
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Hamdan AL-JahdaliPrabhakar RajiahCarolyn AllenShyam Sunder KoteyarAli Nawaz Khan Source Type: research

Pressure-controlled versus volume-controlled ventilation during one-lung ventilation in elderly patients with poor pulmonary function
Conclusions: The use of PCV compared with VCV during OLV in elderly patients with poor pulmonary function has significant advantages of intraoperative and postoperative oxygenation and it might be a factor, which can beneficial to postoperative recovery. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Fei LinLinghui PanBin HuangLin RuanRui LiangWei QianWanyun Ge Source Type: research

Pulmonary arterial hypertension in Saudi Arabia: Patients' clinical and physiological characteristics and hemodynamic parameters. A single center experience
Conclusion: This data highlights the current situation of pulmonary arterial hypertension in Saudi Arabia. Our patients are much younger than patients described in other international registries but still detected as late in the course of the disease. A majority of patients displays severe functional and hemodynamic compromise. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: MM IdreesK Al-NajashiA KhanS Al-DammasH Al-AwwadE BatubaraA Al OtaiJ AbdulhameedA FayedT KashourSAPH Registry Taskforce Source Type: research

Allergic bronchopulmonary aspergillosis: A clinical review of 24 patients: Are we right in frequent serologic monitoring?
Conclusion: ABPA is a disease with varied clinical, radiological, and serological patterns. Serum IgE monitoring may be done at the end of 2 and 6 months. Further studies are required to simplify the diagnosis and treatment algorithms in resource-limited countries. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Subramanian NatarajanPoonam Subramanian Source Type: research

Association of compliance of ventilator bundle with incidence of ventilator-associated pneumonia and ventilator utilization among critical patients over 4 years
Conclusion: More than 70% improvement of VAP rates and approximately 20% improvement of ventilator utilization were observed during IHI ventilator bundle implementation among adult critical patients in a tertiary care center in Saudi Arabia. Replicating the current finding in multicenter randomized trials is required before establishing any causal link. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Majid S Al-ThaqafyAiman El-SaedYaseen M ArabiHanan H Balkhy Source Type: research

18F-FDG PET/CT rarely provides additional information other than primary tumor detection in patients with pulmonary carcinoid tumors
Conclusion: Although FDG PET/CT can be a useful tool for the detection of pulmonary carcinoid tumors and distant metastasis, it cannot discriminate typical carcinoids from atypical ones and absence of an FDG avid lesion cannot exclude pulmonary carcinoid tumors. Moreover, PET/CT is not a reliable tool in the staging of mediastinal and hilar lymph nodes especially for those patients with typical carcinoids. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Ebru TatciOzlem OzmenAtila GokcekInci Uslu BinerEsra OzaydinSadi KayaNuri Arslan Source Type: research

Value of neutrophil/lymphocyte ratio in the differential diagnosis of sarcoidosis and tuberculosis
Conclusion: NLR as a little known marker in respiratory medicine was found to be supportive in differentiation of tuberculosis and sarcoidosis. More studies on this issue is needed. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Sinem IliazRaim IliazGonenc OrtakoyluAyse BahadirBelma Akbaba BagciEmel Caglar Source Type: research

Prevalence of sleep-related accidents among drivers in Saudi Arabia
Conclusion: Sleepy driving is prevalent among male drivers in Saudi Arabia. Near-miss accidents caused by sleepiness are an important risk factor for car accidents and should be considered as a strong warning signal of future accidents. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Ahmad S BaHammamMuath A AlkhunizanRabea H LesloumAmer M AlshanqitiAbdulrahman M AldakhilSeithikurippu R Pandi-PerumalMunir M Sharif Source Type: research

Hemoptysis due to pulmonary pseudosequestration secondary to gastro-pulmonary fistula after a revisional bariatric operation
We report the case of a patient with a history of a complicated revisional bariatric operation who developed a lung pseudosequestration secondary to a gastro-pulmonary fistula. As the patient presented with recurrent hemoptysis, she was initially submitted to embolization of the aberrant vessels and later to a definite operation, which consisted on a diversion of the gastric fistula into a Roux-en-Y intestinal loop. It is an exceptional case about late complications of bariatric surgery, and it underlines the importance of discarding these complications even when the clinical manifestations affect another anatomic region d...
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Carlos Cerdán SantacruzMaría Conde RodríguezAndrés Sánchez-PernauteAntonio José Torres García Source Type: research

Recurrent intrathoracic solitary fibrous tumor: Remarkable response to radiotherapy
We presented a rare case of recurrent malignant intrathoracic solitary fibrous tumor. It was impossible to resect the tumor. Radiotherapy alone achieved a significant improvement effect. (Source: Annals of Thoracic Medicine)
Source: Annals of Thoracic Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Min LiuBin LiuLihua DongBailong Liu Source Type: research

Hypoalbuminemia in critically sick children
Conclusions: Hypoalbuminemia is a significant indicator of mortality and morbidity in critically sick children. More studies are needed to define role of albumin infusion in treatment of such patients. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - September 4, 2014 Category: Intensive Care Authors: Lokesh K TiwariSunit SinghiM JayashreeArun K BaranwalArun Bansal Source Type: research

Brainstem death: A comprehensive review in Indian perspective
Anant Dattatray DhanwateIndian Journal of Critical Care Medicine 2014 18(9):596-605With the advent of cardiopulmonary resuscitation techniques, the cardiopulmonary definition of death lost its significance in favor of brain death. Brain death is a permanent cessation of all functions of the brain in which though individual organs may function but lack of integrating function of the brain, lack of respiratory drive, consciousness, and cognition confirms to the definition that death is an irreversible cessation of functioning of the organism as a whole. In spite of medical and legal acceptance globally, the concept of brain ...
Source: Indian Journal of Critical Care Medicine - September 4, 2014 Category: Intensive Care Authors: Anant Dattatray Dhanwate Source Type: research

Early radiologic evidence of severe respiratory distress syndrome as a predictor of nasal continuous positive airway pressure failure in extremely low birth weight newborns
R A Polin (Source: Journal of Perinatology)
Source: Journal of Perinatology - September 4, 2014 Category: Perinatology & Neonatology Authors: T TagliaferroD BatemanC Ruzal-ShapiroR A Polin Source Type: research

Continuous Renal Replacement Therapy During Extracorporeal Membrane Oxygenation in Patients Treated in Medical Intensive Care Unit: Technical Considerations
Abstract Extracorporeal membrane oxygenation (ECMO) is used as a salvage therapy in refractory acute respiratory distress syndrome (ARDS). Although technological progress in the ECMO systems improved the survival rate, prognosis is still significantly worsened by acute kidney injury (AKI), particularly if renal replacement therapy (RRT) is required. There are no exact guidelines recommending which techniques of ECMO and continuous RRT (CRRT) should be used for management of AKI coexisting with respiratory or circulatory failure, and how to combine them. The aim of this review is to describe methods of CRRT and ECMO simulta...
Source: Therapeutic Apheresis and Dialysis - September 4, 2014 Category: Hematology Authors: Bożena Seczyńska, Wiesław Królikowski, Ilona Nowak, Miłosz Jankowski, Konstanty Szułdrzyński, Wojciech Szczeklik Tags: Review Source Type: research

Factors signifying gender differences in clinical presentation of sarcoidosis among Estonian population
ConclusionWomen with sarcoidosis are independently characterized by greater airflow obstruction, lower lung diffusing coefficient, older age, less smoking and more frequent extrapulmonary complaints and musculoskeletal involvement. This may urge special attention when addressing female patients in both differential diagnostic and management settings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Hille Lill, Kai Kliiman, Alan Altraja Tags: Original Article Source Type: research

Airway bacterial colonization and serum C‐reactive protein are associated with chronic obstructive pulmonary disease exacerbation following bronchoscopic lung Volume Reduction
ConclusionsABC is common in severe COPD patients undergoing BLVR and along with elevated CRP level both are associated with high risk of immediate post‐procedural COPD exacerbation. These patients should be identified , carefully observed,and possibly benefit from prophylactic microbiologically directed antibiotic treatment. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Oren Fruchter, Dror Rosengarten, Elad Goldbeg, Haim Ben‐Zvi, Ruth Tor, Mordechai R. Kramer Tags: Original Article Source Type: research

Exercise‐induced respiratory symptoms and allergy in elite athletes: Allergy and Asthma in Polish Olympic Athletes (A2POLO) project within GA2LEN initiative
ConclusionsHigh prevalence of exercise‐induced respiratory symptoms among top athletes is not reflected by asthma diagnosis. As it was expected, our data confirm that ‐ in diagnosis of EIA ‐ lung function testing alone is not useful whereas reversibility tests are of limited value. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Marcin Kurowski, Janusz Jurczyk, Hubert Krysztofiak, Marek L. Kowalski Tags: Original Article Source Type: research

Cryptogenic organizing pneumonia in Sweet's syndrome: Case report and review of the literature
We describe the case of a 17 year‐old man with a myelodysplastic syndrome following therapy for Hodgkin's lymphoma, who developed Sweet's syndrome and cryptogenic organizing pneumonia. Review of the English literature yielded six similar reports of biopsy‐proven cryptogenic organizing pneumonia associated with Sweet's syndrome. We present the clinical and laboratory characteristics as well as the response to treatment of all cases of cryptogenic organizing pneumonia reported in patients with Sweet's syndrome. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Elias Tzelepis, Christos F Kampolis, Ioanna Vlachadami, Maria Moschovi, Maria Alamani, Gregory Kaltsas Tags: Other Source Type: research

The relationship between red cell distribution width and chronic thromboembolic pulmonary hypertension
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Mehmet Agilli, Fevzi Nuri Aydin, Tuncer Cayci, Yasemin Gulcan Kurt Tags: Letters to the Editor Source Type: research

Holter ECG Monitoring of Sympathovagal Fluctuation During Bronchoscopy
ConclusionsThis study shows for the first time that Holter ECG monitoring during diagnostic bronchoscopy was associated with activation of cardiac sympathetic and withdrawal of cardiac parasympathetic regulation which may contribute to the occurrence of cardiac events during bronchoscopic procedures. So, Holter ECG monitoring during bronchoscopic procedures may confer reduction in cardiovascular events. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - September 4, 2014 Category: Respiratory Medicine Authors: Abdellah Hamed Khalil Ali, Hiroaki Toba, Shoji Sakiyama, Ryo Yamamoto, Hiromitsu Takizawa, Koichiro Kenzaki, Kazuya Kondo, Akira Tangoku Tags: Original Article Source Type: research

FGF Receptor Inhibition is Active Against Mesothelioma and Synergizes with Radio- and Chemotherapy.
Conclusions: Our data suggest that the malignant phenotype of mesothelioma cells depends on intact fibroblast growth factor signals, which consequently should be considered as therapeutic targets with a promising chemo- and radio-sensitizing potential. PMID: 25188816 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 4, 2014 Category: Respiratory Medicine Authors: Schelch K, Hoda MA, Klikovits T, Münzker J, Ghanim B, Wagner C, Garay T, Laszlo V, Setinek U, Dome B, Filipits M, Pirker C, Heffeter P, Selzer E, Tovari J, Torok S, Kenessey I, Holzmann K, Grasl-Kraupp B, Marian B, Klepetko W, Berger W, Hegedus B, Grusch Tags: Am J Respir Crit Care Med Source Type: research

SERCA: A Critical Target in Chlorine Inhalation-induced Cardiotoxicity.
Abstract Autopsy specimens from human victims or experimental animals that die due to acute chlorine gas exposure present features of cardiovascular pathology. We demonstrate acute chlorine inhalation-induced reduction in heart rate and oxygen saturation in rats. Chlorine inhalation elevated chlorine reactants like chlorotyrosine and chloramine in blood plasma. Using heart tissue and primary cardiomyocytes, we demonstrated that acute high concentration chlorine exposure in vivo (500 ppm for 30 min) caused decreased total ATP content and loss of sarco-endoplasmic reticulum calcium ATPase, SERCA, activity. Loss of SE...
Source: Am J Respir Cell Mol... - September 4, 2014 Category: Respiratory Medicine Authors: Ahmad S, Ahmad A, Hendry-Hofer TB, Loader JE, Claycomb WC, Mozziconacci O, Schöneich C, Reisdorph N, Powell RL, Chandler JD, Day BJ, Veress LA, White CW Tags: Am J Respir Cell Mol Biol Source Type: research

Lung Specific Loss of α3 Laminin Worsens Bleomycin-induced Pulmonary Fibrosis.
Abstract Laminins are heterotrimeric proteins that are secreted by the alveolar epithelium into the basement membrane and their expression is altered in extracellular matrices from patients with pulmonary fibrosis. In a small number of patients with pulmonary fibrosis, we found that the normal basement membrane distribution of the α3 laminin subunit was lost in fibrotic regions of the lung. To determine if these changes play a causal role in the development of fibrosis, we generated mice conditionally deficient in α3 laminin in the lung epithelium (SPC-Cre/Lama3(fl/fl)). These mice exhibited no developmental abno...
Source: Am J Respir Cell Mol... - September 4, 2014 Category: Respiratory Medicine Authors: Morales-Nebreda LI, Rogel MR, Eisenberg JL, Hamill KJ, Soberanes S, Nigdelioglu R, Cho MC, Radigan KA, Ridge KM, Misharin AV, Woychek A, Hopkinson S, Perlman H, Mutlu GM, Pardo A, Selman M, Jones JC, Budinger GR Tags: Am J Respir Cell Mol Biol Source Type: research

Emphysema Requires the Receptor for Advanced Glycation End Products Triggering on Structural Cells.
Abstract Pulmonary emphysema is characterized by persistent inflammation and progressive alveolar destruction. The receptor for advanced glycation end products (RAGE) is a multi-ligand cell surface receptor reported to be involved in the process of acute alveolar epithelial cell injury. However, studies that address the role of RAGE in pulmonary emphysema are inconclusive. We investigated the role of RAGE in the development of elastase-induced pulmonary inflammation and emphysema in mice. RAGE sufficient (RAGE+/+) mice and RAGE deficient (RAGE-/-) mice were treated with intratracheal elastase on day 0. Airway infla...
Source: Am J Respir Cell Mol... - September 4, 2014 Category: Respiratory Medicine Authors: Waseda K, Miyahara N, Taniguchi A, Kurimoto E, Ikeda G, Koga H, Fujii U, Yamamoto Y, Gelfand EW, Yamamoto H, Tanimoto M, Kanehiro A Tags: Am J Respir Cell Mol Biol Source Type: research

High-Frequency Chest Wall Oscillation in Prolonged Mechanical Ventilation Patients-a Randomized Controlled Trial.
CONCLUSION: In PMV patients, HFCWO was safe, comfortable, and effective in facilitating airway hygiene after removal of endotracheal tubes, but had no positive impact on weaning success. REGISTRATION: Clinical Trials.gov (identifier NCT02077738). PMID: 25185863 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 4, 2014 Category: Respiratory Medicine Authors: Huang WC, Wu PC, Chen CJ, Cheng YH, Shih SJ, Chen HC, Wu CL Tags: Clin Respir J Source Type: research

Determinants of use of the bronchodilator test in primary and secondary care. Results of a national survey in Spain.
CONCLUSIONS: The present study identifies determinants of the performance of the BDT in Spain identifying strengths and weaknesses. Health managers should use this information to improve the quality of spirometries in chronic respiratory patients. PMID: 25185741 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 4, 2014 Category: Respiratory Medicine Authors: Lopez-Campos JL, Soriano JB, Calle M, 3E project Tags: Clin Respir J Source Type: research

Racial Difference in Sarcoidosis Mortality in the United States.
Conclusions.This nationwide population-based study exposes a significant difference in ethnicity and gender among those dying of sarcoidosis in the United States. Pulmonary hypertension investigation should be considered in all patients with sarcoidosis, especially African Americans. Background.: The clinical presentation and outcome of sarcoidosis varies by race. However, the race difference in mortality outcome remains largely unknown. Methods.: We studied mortality related to sarcoidosis from 1999 through 2010 by examining multiple-cause-of-death data from the National Center for Health Statistics. We compared t...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Mirsaeidi M, Machado RF, Schraufnagel D, Sweiss NJ, Baughman RP Tags: Chest Source Type: research

Gender and Acetazolamide Effects on Chemoreflex and Periodic Breathing During Sleep at Altitude.
Conclusions.The greater severity of periodic breathing during sleep displayed by males at altitude could be attributed to their increased hypoxic chemosensitivity. Acetazolamide counteracted the occurrence of periodic breathing at altitude in both genders, modifying the apneic threshold and improving oxygenation. Clinical Trial Registration.EudraCT code-number 2010-019986-27. Background.: Nocturnal periodic breathing occurs more frequently in males than in females in various clinical and pathophysiological conditions. The mechanisms accounting for this gender-related difference are not completely understood. Acetazolam...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Caravita S, Faini A, Lombardi C, Valentini M, Gregorini F, Rossi J, Meriggi P, Di Rienzo M, Bilo G, Agostoni P, Parati G Tags: Chest Source Type: research

Ultrasound guided medical thoracoscopy in the absence of pleural effusion.
ConclusionWe have shown that thoracic ultrasound is accurate in identify intrathoracic adhesions and in experienced hands can guide medical thoracoscopy access, replacing VATS approach, even in the complete absence of pleural effusion. Background: Medical Thoracoscopy (MT) is a diagnostic and therapeutic procedure, which permits to study the pleural space. The presence of pleural adhesions is the most important contraindication to performing MT. Lesions of the pleura in absence of pleural effusion are usually studied in video-assisted thoracoscopic surgery (VATS) with preoperative ultrasound evaluation. No data are ava...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Marchetti G, Valsecchi A, Indellicati D, Arondi S, Trigiani M, Pinelli V Tags: Chest Source Type: research

Outcomes after Hospitalization in Idiopathic Pulmonary Fibrosis: a cohort study.
Conclusions:Hospitalizations are common events in IPF patients. Most hospitalizations are respiratory-related and are associated with high in-hospital mortality and limited survival beyond discharge. Both all-cause hospitalization and respiratory hospitalization are associated with mortality, and therefore either could be utilized as an endpoint in IPF clinical trials. Background: The outcomes of IPF patients who undergo hospitalization have not been well characterized. We sought to evaluate the frequency and impact of all-cause as well as respiratory-related hospitalizations on the subsequent course and survival of pa...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Brown AW, Fischer CP, Shlobin OA, Buhr RG, Ahmad S, Weir NA, Nathan SD Tags: Chest Source Type: research

Anatomy and Neurophysiology of Coughing: CHEST Guideline and Expert Panel Report.
Abstract ABSTRACT: Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves innervating other viscera as well as somatosensory nerves innervating the chest wall, diaphragm and abdominal musculature regulate cough patterning and cough sensitivity. The responsiveness and morphology of the airway vagal sensory nerve subtypes and the extrapulmonary sensory nerves th...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Canning BJ, Chang AB, Bolser DC, Smith JA, Mazzone SB, McGarvey L Tags: Chest Source Type: research

Accuracy of FDG-PET for differentiating benign from malignant pleural effusions: A meta-analysis.
ConclusionsThe moderate accuracy of PET-CT using semi-quantitative readings precludes its routine recommendation for discriminating malignant from benign pleural effusions. Systematic Review Registration NumberInternational Prospective Register of Systematic Reviews (PROSPERO) Identifier: CRD42011001392. http://www.crd.york.ac.uk/prospero/ Background: The role of FDG-PET imaging for diagnosing malignant pleural effusions is not well defined. The aim of this study was to summarize the evidence for its use in ruling in or out the malignant origin of a pleural effusion and/or thickening. Methods: Meta-analysis of diag...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Porcel JM, Hernández P, Martínez-Alonso M, Bielsa S, Salud A Tags: Chest Source Type: research

Impact of COPD on the Mortality and Treatment of Patients Hospitalized with Acute Decompensated Heart Failure (The Worcester Heart Failure Study).
Conclusions:COPD is a common co-morbidity in patients hospitalized with ADHF and is associated with a worse long-term prognosis. Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities. Background: Chronic obstructive pulmonary disease(COPD) is a common co-morbidity in patients with heart failure, yet little is known about the impact of this condition in patients with acute decompensated heart failure (ADHF), especially from a more generalizable, community-based perspective. The primary objective of this study...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Fisher K, Stefan M, Darling C, Lessard D, Goldberg RJ Tags: Chest Source Type: research

Palliative Care and Location of Death in Decedents with Idiopathic Pulmonary Fibrosis.
Conclusion:The majority of IPF patients died in a hospital setting and only a minority received a formal palliative care referral. Referral to palliative care occurred late in the disease. These findings indicate the need to study adequacy of end-of-life management in IPF and promote earlier discussion and referral to palliative care. Rationale: Palliative care, integrated early, may reduce symptom burden in patients with idiopathic pulmonary fibrosis (IPF). However, limited information exists on timing and clinical practice. The purpose of this study was to describe the time course of events prior to death in patients...
Source: Chest - September 4, 2014 Category: Respiratory Medicine Authors: Lindell KO, Liang Z, Hoffman LA, Rosenzweig MQ, Saul MI, Pilewski JM, Gibson KF, Kaminski N Tags: Chest Source Type: research

Dietary Apostichopus japonicus enhances the respiratory and intestinal mucosal immunity in immunosuppressive mice.
This study aimed to explore the effects of dietary A. japonicus on mucosal immunity with an immunosuppressive mouse model. The expression of lysozyme, secretory immunoglobulin A(sIgA), and immunoglobulin A(IgA) as well as polymeric immunoglobulin receptor(pIgR) in respiratory and intestine organs was investigated. The results showed that A. japonicus could improve both the systematic and mucosal immunity. The expression of lysozyme, sIgA, and IgA in the respiratory organ was increased more significantly. Consumption of A. japonicus with the dose of 512 mg kg(-1), which equals to (1)/2 sea cucumber per day for adults, sho...
Source: Bioscience, Biotechnology, and Biochemistry - September 4, 2014 Category: Biochemistry Authors: Zheng R, Li X, Cao B, Zuo T, Wu J, Wang J, Xue C, Tang Q Tags: Biosci Biotechnol Biochem Source Type: research

Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum
Background: COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory foci through regulation of the chemokine CCL3. We hypothesized that there would be enhanced levels of IL-6, sIL-6R and CCL3 in COPD sputum. Methods: 59 COPD patients, 15 HNS and 15 S underwent sputum induction and processing with phosphate buffered saline to obtain supernatants for IL-6, sIL-6R and CCL3 analysis. Cytoslides were produced for differential cell counting and immunocytochemistry (COPD; n =...
Source: Respiratory Research - September 4, 2014 Category: Respiratory Medicine Authors: Arjun RaviShruti KhuranaJonathan LemonJonathan PlumbGeorge BoothLouise HealyMatthew CatleyJørgen VestboDave Singh Source Type: research