Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Reasons for failure to quit: a cross-sectional survey of tobacco use in major cities in Pakistan
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Irfan, M.Haque, A. S.Shahzad, H.Samani, Z. A.Awan, S.Khan, J. A. Tags: ORIGINAL ARTICLES Source Type: research

Cigarette smoking in patients newly diagnosed with pulmonary tuberculosis in Iran
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Aryanpur, M.Masjedi, M. R.Hosseini, M.Mortaz, E.Tabarsi, P.Soori, H.Emami, H.Heydari, G.Baikpour, M. Tags: ORIGINAL ARTICLES Source Type: research

Efficacy of zinc sulphate on in-hospital outcome of community-acquired pneumonia in people aged 50 years and over
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Sharafi, S.Allami, A. Tags: ORIGINAL ARTICLES Source Type: research

Associations between inhaler technique and asthma control among asthma patients using pressurised MDIs and DPIs
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Basheti, I. A.Obeidat, N. M.Ammari, W. G.Reddel, H. K. Tags: ORIGINAL ARTICLES Source Type: research

Solar-powered oxygen delivery: proof of concept
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Turnbull, H.Conroy, A.Opoka, R. O.Namasopo, S.Kain, K. C.Hawkes, M. Tags: ORIGINAL ARTICLES Source Type: research

A rare adverse reaction to ethambutol: drug-induced haemolytic anaemia
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Nicolini, A.Perazzo, A.Gatto, P.Piroddi, I. M. G.Barlascini, C.Karamichali, S.Strada, P. Tags: CASE STUDIES Source Type: research

Inoculation site leprosy in a tattoo as a paradoxical reaction following tuberculosis treatment
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Branagan, P.Moran, B.Fitzgibbon, M.Reid, V.McMenamin, M.Kane, M.Kelly, F.Barnes, L.McLaughlin, A.Keane, J. Tags: CASE STUDIES Source Type: research

Clinical phenotypes in bronchiectasis: right on track to develop precision medicine in respiratory diseases
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Sotgiu, GiovanniDore, SimoneChalmers, James DAliberti, Stefano Tags: CORRESPONDENCE Source Type: research

In Reply: Towards precision medicine: phenotyping bronchiectasis with unsupervised learning technique
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Guan, Wei-JieJiang, MeiGao, Yong-HuaChen, Rong-ChangZhong, Nan-Shan Tags: CORRESPONDENCE Source Type: research

Usefulness of Cyclophosphamide Pulse Therapy in Interstitial Lung Diseases
Conclusions: This retrospective analysis of cyclophosphamide treatment shows a stabilisation of lung function in most patients with fibrotic ILDs, yet prospective studies in clearly defined diagnoses are urgently needed.Respiration (Source: Respiration)
Source: Respiration - April 15, 2016 Category: Respiratory Medicine Source Type: research

Risk of Direct Oral Anticoagulant Bioaccumulation in Patients with Pulmonary Hypertension
Conclusions: About 1 in 2 patients treated with PAH therapy has at least one of the three major risk factors for DOA bioaccumulation. DOAs in the PH setting could be associated with bioaccumulation and should be individualized, mainly in patients with confirmed indication.Respiration (Source: Respiration)
Source: Respiration - April 15, 2016 Category: Respiratory Medicine Source Type: research

Serum Procalcitonin as a Biomarker for the Prediction of Bacterial Exacerbation and Mortality in Severe COPD Exacerbations Requiring Mechanical Ventilation
Background: Procalcitonin (PCT) is being used as a marker of bacterial infections. Although there are several studies showing the diagnostic yield of PCT to differentiate bacterial involvement in chronic obstructive pulmonary disease exacerbations (COPDE), the prognostic yield of PCT in severe COPDE has been studied less. Objectives: The primary aim was to determine whether the level of serum PCT at admission in severe COPDE serves as a prognostic biomarker for hospital mortality. The secondary aim was to determine the role of PCT in identifying a bacterial exacerbation. Methods: A total of 63 COPDE patients (median age 71...
Source: Respiration - April 15, 2016 Category: Respiratory Medicine Source Type: research

Recent Declines in Infant and Neonatal Mortality in Turkey from 2007 to 2012: Impact of Improvements in Health Policies.
CONCLUSION: From 2007-2012, Turkey showed remarkable encouraging advances in reducing IMR and NMR. Any interventions aimed at further reductions in IMR and NMR should target the common causes of death and defined risk factors especially in socioeconomically disadvantaged regions. PMID: 27070970 [PubMed - in process] (Source: Central European Journal of Public Health)
Source: Central European Journal of Public Health - April 15, 2016 Category: Global & Universal Tags: Cent Eur J Public Health Source Type: research

Safety concerns with long-term opioid use.
Authors: Harned M, Sloan P Abstract INTRODUCTION: The benefits of opioid therapy must be balanced by any adverse effects. In recent years, prescription opioids have been increasingly prescribed, but have also been associated with increased abuse, overdose and death. Areas Covered: This review will categorize the common risks of opioid administration. Recognized adverse effects of opioid therapy include constipation, tolerance, endocrinopathies, sleep disorders, cognitive effects, respiratory depression, overdose and addiction. Studies have shown that there is increased risk of overdose and death with higher daily o...
Source: Expert Opinion on Drug Safety - April 15, 2016 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Commercial Motor Vehicle Driver Positive Airway Pressure Therapy Adherence in a Sleep Center
Conclusions:Early PAP utilization patterns predicted one year adherence for our CMV driver population within a sleep clinic setting. OSA testing of these CMV drivers after occupational health referral identifies high proportions of undiagnosed OSA, with approximately half requiring PAP therapy based on current published treatment recommendations.Citation:Colvin LJ, Dace GA, Colvin RM, Ojile J, Collop N. Commercial motor vehicle driver positive airway pressure therapy adherence in a sleep center. J Clin Sleep Med 2016;12(4):477–485. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2016 Category: Sleep Medicine Source Type: research

Effect of Sleep State and Position on Obstructive Respiratory Events Distribution in Adolescent Children
Conclusions:This study shows that sleep related obstructive respiratory events in the adolescents (12 to 18 y of age) occur predominantly in REM sleep and in supine position.Citation:El-Kersh K, Cavallazzi R, Patel PM, Senthilvel E. Effect of sleep state and position on obstructive respiratory events distribution in adolescent children. J Clin Sleep Med 2016;12(4):513–517. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2016 Category: Sleep Medicine Source Type: research

Respiratory Variability during Sleep in Methadone Maintenance Treatment Patients
Conclusions:MMT patients have a higher respiratory variability during sleep than healthy controls. Semi-automated variability measures are related to apnea indices obtained by manual scoring and may provide a new approach to quantify opioid-related sleep-disordered breathing.Citation:Nguyen CD, Kim JW, Grunstein RR, Thamrin C, Wang D. Respiratory variability during sleep in methadone maintenance treatment patients. J Clin Sleep Med 2016;12(4):607–616. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2016 Category: Sleep Medicine Source Type: research

Simultaneous MV-kV imaging for intrafractional motion management during volumetric-modulated arc therapy delivery.
Abstract The purpose of this study was to evaluate the accuracy and clinical feasibility of a motion monitoring method employing simultaneously acquired MV and kV images during volumetric-modulated arc therapy (VMAT). Short-arc digital tomosynthesis (SA-DTS) is used to improve the quality of the MV images that are then combined with orthogonally acquired kV images to assess 3D motion. An anthropomorphic phantom with implanted gold seeds was used to assess accuracy of the method under static, typical prostatic, and respiratory motion scenarios. Automatic registra-tion of kV images and single MV frames or MV SA-DTS r...
Source: Journal of Applied Clinical Medical Physics - April 15, 2016 Category: Physics Authors: Hunt MA, Sonnick M, Pham H, Regmi R, Xiong JP, Morf D, Mageras GS, Zelefsky M, Zhang P Tags: J Appl Clin Med Phys Source Type: research

Quantitative outcome of registration methods for correcting cardiac drift in cardiac PET/CT imaging.
This study evaluates three postimaging registration techniques to correct PET/CT misalignment by altering the transmission map to match myo-cardial uptake. Simulated misalignment studies were performed with a cardiac torso phantom filled with [18F]FDG at 10:1 myocardium/background. An air-filled saline bag affixed to the medial left lung surface served as a distensible lung. An initial CT acquisition was followed by successive PET acquisitions consisting of small displacements of the cardiac insert into the left lung. Phantom transmission scans were aligned to the myocardial uptake in the emission scans by applying 1) full...
Source: Journal of Applied Clinical Medical Physics - April 15, 2016 Category: Physics Authors: Nye JA, Tudorascu D, Esteves F, Votaw JR Tags: J Appl Clin Med Phys Source Type: research

Perturbation of water-equivalent thickness as a surrogate for respiratory motion in proton therapy.
Abstract Respiratory motion is traditionally assessed using tumor motion magnitude. In proton therapy, respiratory motion causes density variations along the beam path that result in uncertainties of proton range. This work has investigated the use of water-equivalent thickness (WET) to quantitatively assess the effects of respiratory motion on calculated dose in passively scattered proton therapy (PSPT). A cohort of 29 locally advanced non-small cell lung cancer patients treated with 87 PSPT treatment fields were selected for analysis. The variation in WET (ΔWET) along each field was calculated between exhale and...
Source: Journal of Applied Clinical Medical Physics - April 15, 2016 Category: Physics Authors: Matney JE, Park PC, Li H, Court LE, Zhu XR, Dong L, Liu W, Mohan R Tags: J Appl Clin Med Phys Source Type: research

The Diagnosis and Management of Patient with Delayed Symptoms from a Tracheal Tear
Development of subcutaneous emphysema after gastrointestinal endoscopy with general anesthesia presents a diagnostic conundrum. We discuss the management of a patient who experienced significant vomiting followed by neck and facial swelling with crepitus and shortness of breath after the endoscopic retrograde cholangiopancreatography. The presence of respiratory distress usually suggests that head and neck subcutaneous emphysema is most likely associated with pneumothorax and/or pneumomediastinum. We discuss the prevention, differential diagnosis, and current management of tracheal tears including subcutaneous emphysema. (...
Source: A&A Case Reports - April 15, 2016 Category: Anesthesiology Tags: Case Reports: Clinical Care Source Type: research

Antibiotic Utilization and Opportunities for Stewardship Among Hospitalized Patients With Influenza Respiratory Tract Infection
Research Articles Islam M. Ghazi, David P. Nicolau, Michael D. Nailor, Jaber Aslanzadeh, Jack W. Ross, Joseph L. Kuti, Infection Control & Hospital Epidemiology, Volume 37 Issue 05, pp 583-589Abstract (Source: Infection Control and Hospital Epidemiology)
Source: Infection Control and Hospital Epidemiology - April 15, 2016 Category: Epidemiology Source Type: research

Sleep Perception in Obstructive Sleep Apnea: A Study Using Polysomnography and the Multiple Sleep Latency Test.
CONCLUSIONS: As an objectively good sleep does not match the subjective good-sleep perception in OSA, physicians should keep in mind that OSA patients who perceive that they have slept well does not mean that their OSA is less severe. PMID: 27074296 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - April 15, 2016 Category: Neurology Tags: J Clin Neurol Source Type: research

Leigh Syndrome in Childhood: Neurologic Progression and Functional Outcome.
CONCLUSIONS: The neurological severity and outcome of LS may vary widely and be better than those predicted based on previous studies. We suggest that age at onset and initial neuroimaging findings are prognostic indicators in LS. PMID: 27074294 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - April 15, 2016 Category: Neurology Tags: J Clin Neurol Source Type: research

Chronic Obstructive Pulmonary Disease and Cardiac Repolarization: Data from a Randomized Controlled Trial
Conclusion: LVRS seems to have no effect on cardiac repolarization in patients with COPD. Thus, lung hyperinflation seems not to be a causal mechanism for altered cardiac repolarization in COPD patients.Respiration (Source: Respiration)
Source: Respiration - April 15, 2016 Category: Respiratory Medicine Source Type: research

Persistent effects of Libby amphibole and amosite asbestos following subchronic inhalation in rats
This study evaluated potency and time-course effects of LA and positive contr... (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - April 15, 2016 Category: Toxicology Authors: Stephen H. Gavett, Carl U. Parkinson, Gabrielle A. Willson, Charles E. Wood, Annie M. Jarabek, Kay C. Roberts, Urmila P. Kodavanti and Darol E. Dodd Source Type: research

Effects of simultaneous palatal expansion and mandibular advancement in a child suffering from OSA.
In conclusion, this case report suggests that orthodontic treatment might be a valuable alternative treatment in children with obstructive sleep apnoea related to craniofacial anomalies. PMID: 27070538 [PubMed - as supplied by publisher] (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - April 15, 2016 Category: ENT & OMF Tags: Acta Otorhinolaryngol Ital Source Type: research

Complete genome sequence of Enterococcus faecalis LD33, a bacteriocin-producing strain
Publication date: Available online 14 April 2016 Source:Journal of Biotechnology Author(s): Jiao Yuehua, Zhang Lanwei, Liu Fei, Yi Huaxi, Han Xue Enterococcus faecalis LD33 strain was originally isolated from traditional naturally fermented cream in Inner Mongolia of China. Its complete genome sequence was carried out using the Illumina Hiseq and the PacBio RSII platform. The genome only has a circular chromosome and a GC content of 37.58%. Other core information shown in the genome sequencing results give further insight on this bacterium’s genetic elements for bacteriocin production and the genes related to resp...
Source: Journal of Biotechnology - April 15, 2016 Category: Biotechnology Source Type: research

ERRα-Regulated Lactate Metabolism Contributes to Resistance to Targeted Therapies in Breast Cancer
Publication date: 12 April 2016 Source:Cell Reports, Volume 15, Issue 2 Author(s): Sunghee Park, Ching-Yi Chang, Rachid Safi, Xiaojing Liu, Robert Baldi, Jeff S. Jasper, Grace R. Anderson, Tingyu Liu, Jeffrey C. Rathmell, Mark W. Dewhirst, Kris C. Wood, Jason W. Locasale, Donald P. McDonnell Imaging studies in animals and in humans have indicated that the oxygenation and nutritional status of solid tumors is dynamic. Furthermore, the extremely low level of glucose within tumors, while reflecting its rapid uptake and metabolism, also suggests that cancer cells must rely on other energy sources in some...
Source: Cell Reports - April 15, 2016 Category: Cytology Source Type: research

Trends in the Burden of Adult Congenital Heart Disease in US Emergency Departments
ConclusionsThere has been a progressive increase in number of ED visits among ACHD patients across 2006–2012 in the United States. Moreover, the cardiovascular risk‐factor profile of ACHD patients has changed, adding to complexity in management. Current health care delivery to ACHD patients also shows significant geographical, hospital‐based, and insurance status–based disparities. (Source: Clinical Cardiology)
Source: Clinical Cardiology - April 15, 2016 Category: Cardiology Authors: Shikhar Agarwal, Karan Sud, Sahil Khera, Dhaval Kolte, Gregg C. Fonarow, Julio A. Panza, Venu Menon Tags: Clinical Investigations Source Type: research

Idiopathic Pulmonary Fibrosis and the Elderly: Diagnosis and Management Considerations
Abstract Idiopathic pulmonary fibrosis (IPF) is a severe and progressive fibrosing interstitial lung disease, which ultimately results in respiratory failure and death. The median age at diagnosis is 66 years, and the incidence increases with age, making this a disease that predominantly affects the elderly population. IPF can often be difficult to diagnose, as its symptoms—cough, dyspnoea and fatigue—are non-specific and can often be attributed to co-morbidities such as heart failure and chronic obstructive pulmonary disease. Making an accurate diagnosis of IPF is imperative, as new treatments that appear to...
Source: Drugs and Aging - April 15, 2016 Category: Geriatrics Source Type: research

Initial experience of generalized intravoxel incoherent motion imaging and diffusion tensor imaging (GIVIM‐DTI) in healthy subjects
ConclusionGIVIM‐DTI shows promise for advancing the characterization of the renal microstructure and microcirculation. J. Magn. Reson. Imaging 2016. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - April 15, 2016 Category: Radiology Authors: Qiong Ye, Zhongwei Chen, Youfan Zhao, Zhenhua Zhang, Haiwei Miao, Qinqin Xiao, Meihao Wang, Jiance Li Tags: Original Research Source Type: research

Evaluation of a respiratory navigator-gating technique in Gd-EOB-DTPA-enhanced magnetic resonance imaging for the assessment of liver tumors
Conclusions Navigator-gated imaging provided image qualities and detection rates of malignant liver lesions comparable to breath-hold imaging in Gd-EOB-DTPA-enhanced MR imaging; however, no additional benefits of high-resolution imaging were proven for lesion evaluation. (Source: European Journal of Radiology)
Source: European Journal of Radiology - April 15, 2016 Category: Radiology Source Type: research

Can we translate findings on inequality in tuberculosis mortality into policy?
This article is currently available as a free download on Ingenta Connect (Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - April 15, 2016 Category: Respiratory Medicine Authors: Van Rie, AnneliesTaylor, Richard Tags: EDITORIALS Source Type: research

How robust are the estimated effects of air pollution on health? Accounting for model uncertainty using Bayesian model averaging
Publication date: Available online 14 April 2016 Source:Spatial and Spatio-temporal Epidemiology Author(s): Francesca Pannullo, Duncan Lee, Eugene Waclawski, Alastair H. Leyland The long-term impact of air pollution on human health can be estimated from small-area ecological studies in which the health outcome is regressed against air pollution concentrations and other covariates, such as socio-economic deprivation. Socio-economic deprivation is multi-factorial and difficult to measure, and includes aspects of income, education, and housing as well as others. However, these variables are potentially highly correlated...
Source: Spatial and Spatio-temporal Epidemiology - April 15, 2016 Category: Epidemiology Source Type: research

The origin of the supernumerary subunits and assembly factors of complex I: A treasure trove of pathway evolution
This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - April 15, 2016 Category: Biochemistry Source Type: research

Ocean Acidification Affects the Phyto-Zoo Plankton Trophic Transfer Efficiency
by Gemma Cripps, Kevin J. Flynn, Penelope K. Lindeque The critical role played by copepods in ocean ecology and biogeochemistry warrants an understanding of how these animals may respond to ocean acidification (OA). Whilst an appreciation of the potential direct effects of OA, due to elevated pCO2, on copepods is improving, little is known about the indirect impacts acting via bottom-up (food quality) effects. We assessed, for the first time, the chronic effects of direct and/or indirect exposures to elevated pCO2 on the behaviour, vital rates, chemical and biochemical stoichiometry of the calanoid copepod Acartia tonsa. ...
Source: PLoS One - April 15, 2016 Category: Biomedical Science Authors: Gemma Cripps Source Type: research

Monitoring of antimicrobial susceptibility of respiratory tract pathogens isolated from diseased cattle and pigs across Europe, 2009-2012: VetPath results
In conclusion, absence or low resistance to antibiotics with defined clinical breakpoints, except for tetracycline, was observed among the major respiratory tract pathogens recovered from livestock. Comparison of all antibiotics and organisms was hampered since for almost half of the antibiotics no CLSI-defined breakpoints were available. (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - April 15, 2016 Category: Veterinary Research Source Type: research

Seroprevalence and factors associated with equine herpesvirus type 1 and 4 in Spanish Purebred horses in Spain
Equine herpesvirus type 1 (EHV-1) and type 4 (EHV-4) have a worldwide distribution and cause respiratory disease, abortion, neonatal death and myeloencephalopathy in susceptible horses. Given the scarcity of serological EHV-1/EHV-4 data in Spain, the objective of this cross-sectional study was to estimate the seroprevalence of EHV-1/EHV-4 and to identify potential horse-level and stud farm-level factors associated with EHV-1/EHV-4 in the breeding Spanish Purebred (SP) horse population in central Spain. Serum samples from 334 SP unvaccinated horses, collected between September 2011 and November 2013 at 30 stud farms, were t...
Source: Veterinary Record - April 15, 2016 Category: Veterinary Research Authors: Cruz, F., Fores, P., Mughini-Gras, L., Ireland, J., Moreno, M. A., Newton, J. R. Tags: Research Source Type: research

Viable influenza A virus in airborne particles expelled during coughs versus exhalations
ConclusionsViable influenza A virus was detected more often in cough aerosol particles than in exhalation aerosol particles, but the difference was not large. Because individuals breathe much more often than they cough, these results suggest that breathing may generate more airborne infectious material than coughing over time. However, both respiratory activities could be important in airborne influenza transmission. Our results are also consistent with the theory that much of the aerosol containing viable influenza originates deep in the lungs. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - April 15, 2016 Category: Virology Authors: William G. Lindsley, Francoise M. Blachere, Donald H. Beezhold, Robert E. Thewlis, Bahar Noorbakhsh, Sreekumar Othumpangat, William T. Goldsmith, Cynthia M. McMillen, Michael E. Andrew, Carmen N. Burrell, John D. Noti Tags: Original Article Source Type: research

Estimating functional brain maturity in very and extremely preterm neonates using automated analysis of the electroencephalogram
Every year, over two million babies are born very or extremely premature, less than 32 weeks gestational age (GA), and will require admission to a neonatal intensive care unit (NICU) (Blencowe et al., 2012). Neurological complications from prematurity can result in a 10 to 25 fold increase in annual healthcare costs (Kancherla et al., 2012). While recent progress in cardio-respiratory intensive care has increased the numbers of surviving neonates; the proportion of survivors with lifelong neurocognitive disabilities has not significantly declined (Saigal and Doyle, 2008; Sellier et al., 2010). (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - April 15, 2016 Category: Neuroscience Authors: J.M. O’Toole, G.B. Boylan, S. Vanhatalo, N.J. Stevenson Source Type: research

Bone scintigraphy as cornerstone in the diagnosis of Erdheim–Chester disease
Publication date: May–June 2016 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 35, Issue 3 Author(s): F.J. García-Gómez, T. Cambil-Molina, J.J. Ríos-Martín, P.A. de la Riva-Pérez, C. Calvo-Morón, J. Castro-Montaño The Erdheim–Chester disease (ECD) is an extremely rare form of non-Langerhans cell histiocytosis. The main difficulty for its diagnosis lies in the wide variety of non-specific symptoms and signs that can occur in the disease process, leading, therefore, to there being no clear-cut algorithm as a guide for an optimal biopsy to confirm the diagnosis. An...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - April 15, 2016 Category: Nuclear Medicine Source Type: research

Use of a Supraglottic Airway to Relieve Ventilation-Impeding Gastric Insufflation During Emergency Airway Management in an Infant
Publication date: Available online 13 April 2016 Source:Annals of Emergency Medicine Author(s): Kenneth W. Dodd, Ashley M. Strobel, Brian E. Driver, Robert F. Reardon Positive-pressure bag-valve-mask ventilation during emergency airway management often results in significant gastric insufflation, which may impede adequate ventilation and oxygenation. Current-generation supraglottic airways have beneficial features, such as channels for gastric decompression while ventilation is ongoing. A 5-week-old female infant required resuscitation for hypoxemic respiratory failure caused by rhinovirus with pneumonia. Bag-valve-m...
Source: Annals of Emergency Medicine - April 15, 2016 Category: Emergency Medicine Source Type: research

Sleep study as a diagnostic tool for unexplained respiratory failure in infants hospitalized in the PICU
Conclusions PG may assist the diagnosis and guide the management of unexplained respiratory failure or life-threatening events in infants hospitalized in the PICU. (Source: Journal of Critical Care)
Source: Journal of Critical Care - April 15, 2016 Category: Gastroenterology Source Type: research

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders
Conclusions Convergent lines of evidence link chronic hyperglycemic conditions to aberrant expression of AGEs/RAGEs and HBP signaling pathways in relation to the pathophysiological formation of ROS and pro-inflammatory processes on the functional dysregulation of mitochondrial bioenergetics. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - April 15, 2016 Category: Nutrition Source Type: research

VIP-loaded PLGA as an anti-asthma nanodrug candidate
Abstract Poly lactic-co-glycolic acid (PLGA), a biodegradable polymer, can effectively protect encapsulated peptides from enzymatic degradation. PLGA was approved by FDA as a safe drug delivery system suitable for inhalation administration. Vasoactive intestinal peptide (VIP), a 28-amino-acid peptide, displays anti-inflammatory and anti-spasmodic effects, which can be considered as a new therapeutic option to control and treat asthma. Because of in vivo enzymatic degradation of VIP including in the lung, there is a need for an applicable delivery system. In light of this, the purpose of this study was to prepare V...
Source: Comparative Clinical Pathology - April 15, 2016 Category: Pathology Source Type: research

Increased susceptibility of Cftr-/- mice to LPS-induced lung remodeling
This study shows that chronic inflammation alone contributes significantly to aspects of CF lung pathology. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2016 Category: Respiratory Medicine Authors: Bruscia, E. M., Zhang, P.-X., Barone, C., Scholte, B. J., Homer, R., Krause, D. S., Egan, M. E. Tags: CALL FOR PAPERS Source Type: research

Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase
Transcellular albumin transport occurs via caveolae that are abundant in lung microvascular endothelial cells. Stimulation of albumin transcytosis by proinflammatory mediators may contribute to alveolar protein leak in lung injury, yet the regulation of albumin transport and its underlying molecular mechanisms are so far incompletely understood. Here we tested the hypothesis that thrombin may stimulate transcellular albumin transport across lung microvascular endothelial cells in an acid-sphingomyelinase dependent manner. Thrombin increased the transport of fluorescently labeled albumin across confluent human lung microvas...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2016 Category: Respiratory Medicine Authors: Kuebler, W. M., Wittenberg, C., Lee, W. L., Reppien, E., Goldenberg, N. M., Lindner, K., Gao, Y., Winoto-Morbach, S., Drab, M., Mühlfeld, C., Dombrowsky, H., Ochs, M., Schütze, S., Uhlig, S. Tags: CALL FOR PAPERS Source Type: research

Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming
In this study, we used intratracheal lipopolysaccharide or Pseudomonas bacteria administration to model experimental acute lung injury (ALI) and to further understand mediators of the resolution phase of ARDS. Recent work demonstrates macrophages transition from a predominant proinflammatory M1 phenotype during acute inflammation to an anti-inflammatory M2 phenotype with ALI resolution. We tested the hypothesis that IL-4, a potent inducer of M2-specific protein expression, would accelerate ALI resolution and lung repair through reprogramming of endogenous inflammatory macrophages. In fact, IL-4 treatment was found to offer...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2016 Category: Respiratory Medicine Authors: D'Alessio, F. R., Craig, J. M., Singer, B. D., Files, D. C., Mock, J. R., Garibaldi, B. T., Fallica, J., Tripathi, A., Mandke, P., Gans, J. H., Limjunyawong, N., Sidhaye, V. K., Heller, N. M., Mitzner, W., King, L. S., Aggarwal, N. R. Tags: CALL FOR PAPERS Source Type: research