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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Increased ventilatory variability and complexity in patients with hyperventilation disorder
In conclusion, well-defined patients suffering from hyperventilation disorder are characterized by increased variability of their resting ventilation due to increased ventilatory complexity with stable ventilatory-chemoresponsiveness interactions. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - May 15, 2016 Category: Physiology Authors: Bokov, P., Fiamma, M.-N., Chevalier-Bidaud, B., Chenivesse, C., Straus, C., Similowski, T., Delclaux, C. Tags: ARTICLES Source Type: research

Comparing 3 ventilation modalities by measuring several respiratory parameters using the ProSeal laryngeal mask airway in children
To determine quantitative differences in several routinely measured ventilation parameters using a standardized anesthetic technique and 3 different ventilation modalities in pediatric patients with a ProSeal laryngeal mask airway (PLMA). (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - May 15, 2016 Category: Anesthesiology Authors: T. Wesley Templeton, Lauren K. Hoke, Jill Yaung, Carol A. Aschenbrenner, Danielle M. Rose, Leah B. Templeton, Yvon F. Bryan Tags: Original contribution Source Type: research

Rejection after Lung Transplantation?
Authors: PMID: 27174487 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Erratum: ATS Statement: Guidelines for the Six-Minute Walk Test.
Authors: PMID: 27174486 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply: The Impact of Septic Liver Dysfunction on Long-Term Mortality Must Not Be Neglected.
PMID: 27174485 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Nesseler N, Launey Y, Aninat C, White J, Corlu A, Pieper K, Mall├ędant Y, Seguin P Tags: Am J Respir Crit Care Med Source Type: research

Tempering Sepsis-induced Hyperbilirubinemia: Implications for Short- and Long-Term Outcomes.
PMID: 27174484 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Patel J, Taneja A Tags: Am J Respir Crit Care Med Source Type: research

Nasopharyngeal Microbiome in Respiratory Syncytial Virus Resembles Profile Associated with Increased Childhood Asthma Risk.
PMID: 27174483 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Rosas-Salazar C, Shilts MH, Tovchigrechko A, Chappell JD, Larkin EK, Nelson KE, Moore ML, Anderson LJ, Das SR, Hartert TV Tags: Am J Respir Crit Care Med Source Type: research

Eucapnic Voluntary Hyperpnea Testing in Asymptomatic Athletes.
PMID: 27174482 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Price OJ, Ansley L, Levai IK, Molphy J, Cullinan P, Dickinson JW, Hull JH Tags: Am J Respir Crit Care Med Source Type: research

Update in Chronic Obstructive Pulmonary Disease 2015.
PMID: 27174481 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Marchetti N, Criner GJ Tags: Am J Respir Crit Care Med Source Type: research

Estrogens in Men: Another Layer of Complexity of Estradiol Metabolism in Pulmonary Hypertension.
PMID: 27174480 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Tofovic SP, Jackson EK Tags: Am J Respir Crit Care Med Source Type: research

Estrogen: Friend or Foe in Pulmonary Hypertension?
PMID: 27174479 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: White RJ Tags: Am J Respir Crit Care Med Source Type: research

Mortality Related to Surgical Lung Biopsy in Patients with Interstitial Lung Disease. The Devil Is in the Denominator.
PMID: 27174478 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Raj R, Brown KK Tags: Am J Respir Crit Care Med Source Type: research

The Airway in Idiopathic Pulmonary Fibrosis: Protecting the Lung or Promoting Disease?
PMID: 27174477 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Ryu C, Homer RJ, Herzog EL Tags: Am J Respir Crit Care Med Source Type: research

Ozone and Acute Respiratory Distress Syndrome. It's in the Air We Breathe.
PMID: 27174476 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Reilly JP Tags: Am J Respir Crit Care Med Source Type: research

The Year of Ozone.
PMID: 27174475 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Schwartz J Tags: Am J Respir Crit Care Med Source Type: research

Leukocyte Adhesion Deficiency IV. Monocyte Integrin Activation Deficiency in Cystic Fibrosis.
PMID: 27174474 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Fan Z, Ley K Tags: Am J Respir Crit Care Med Source Type: research

Compartmentalization Is Key in Limiting Nitric Oxide Scavenging by Cell-Free Hemoglobin.
PMID: 27174473 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Kim-Shapiro DB, Patel RP Tags: Am J Respir Crit Care Med Source Type: research

All That Work and No Gain: What Should We Do to Restore Physical Function in Our Survivors?
PMID: 27174472 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - May 15, 2016 Category: Respiratory Medicine Authors: Hodgson CL, Iwashyna TJ, Schweickert WD Tags: Am J Respir Crit Care Med Source Type: research

A three-dimensional human model of the fibroblast activation that accompanies bronchopulmonary dysplasia identifies Notch-mediated pathophysiology
Bronchopulmonary dysplasia (BPD) is a leading complication of premature birth and occurs primarily in infants delivered during the saccular stage of lung development. Histopathology shows decreased alveolarization and a pattern of fibroblast proliferation and differentiation to the myofibroblast phenotype. Little is known about the molecular pathways and cellular mechanisms that define BPD pathophysiology and progression. We have developed a novel three-dimensional human model of the fibroblast activation associated with BPD, and using this model we have identified the Notch pathway as a key driver of fibroblast activation...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Sucre, J. M. S., Wilkinson, D., Vijayaraj, P., Paul, M., Dunn, B., Alva-Ornelas, J. A., Gomperts, B. N. Tags: CALL FOR PAPERS Source Type: research

Isolation of individual cellular components from lung tissues of patients with lymphangioleiomyomatosis
Lymphangioleiomyomatosis (LAM) is a rare neoplastic disease entailing cystic destruction of the lungs and progressive respiratory failure. LAM lungs are histologically characterized by the proliferation of smooth muscle-like cells (LAM cells) and an abundance of lymphatic vessels. To elucidate the pathophysiological processes of LAM, cell-type-specific analyses are required. However, no method exists for isolating the individual types of cells in LAM lesions. Therefore, we established a fluorescence-activated cell sorting (FACS)-based method for the direct isolation of LAM cells and other various cellular components from L...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Ando, K., Fujino, N., Mitani, K., Ota, C., Okada, Y., Kondo, T., Mizobuchi, T., Kurihara, M., Suzuki, K., Hoshika, Y., Ebana, H., Kobayashi, E., Takahashi, K., Kubo, H., Seyama, K. Tags: CALL FOR PAPERS Source Type: research

Absence of TNF-{alpha} enhances inflammatory response in the newborn lung undergoing mechanical ventilation
Bronchopulmonary dysplasia (BPD), characterized by impaired alveolarization and vascularization in association with lung inflammation and apoptosis, often occurs after mechanical ventilation with oxygen-rich gas (MV-O2). As heightened expression of the proinflammatory cytokine TNF-α has been described in infants with BPD, we hypothesized that absence of TNF-α would reduce pulmonary inflammation, and attenuate structural changes in newborn mice undergoing MV-O2. Neonatal TNF-α null (TNF-α–/–) and wild type (TNF-α+/+) mice received MV-O2 for 8 h; controls spontaneously breathed 40% O...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Ehrhardt, H., Pritzke, T., Oak, P., Kossert, M., Biebach, L., Förster, K., Koschlig, M., Alvira, C. M., Hilgendorff, A. Tags: CALL FOR PAPERS Source Type: research

Systematic phenotyping and correlation of biomarkers with lung function and histology in lung fibrosis
To date, phenotyping and disease course prediction in idiopathic pulmonary fibrosis (IPF) primarily relies on lung function measures. Blood biomarkers were recently proposed for diagnostic and outcome prediction in IPF, yet their correlation with lung function and histology remains unclear. Here, we comprehensively assessed biomarkers in liquid biopsies and correlated their abundance with lung function and histology during the onset, progression, and resolution of lung fibrosis, with the aim to more precisely evaluate disease progression in the preclinical model of bleomycin-induced pulmonary fibrosis in vivo. Importantly,...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Fernandez, I. E., Amarie, O. V., Mutze, K., Königshoff, M., Yildirim, A. O., Eickelberg, O. Tags: CALL FOR PAPERS Source Type: research

Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy
Recently approved therapies that modulate CFTR function have shown significant clinical benefit, but recent investigations regarding their molecular mechanism when used in combination have not been consistent with clinical results. We employed micro-optical coherence tomography as a novel means to assess the mechanism of action of CFTR modulators, focusing on the effects on mucociliary clearance. Primary human airway monolayers from patients with a G551D mutation responded to ivacaftor treatment with increased ion transport, airway surface liquid depth, ciliary beat frequency, and mucociliary transport rate, in addition to...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Birket, S. E., Chu, K. K., Houser, G. H., Liu, L., Fernandez, C. M., Solomon, G. M., Lin, V., Shastry, S., Mazur, M., Sloane, P. A., Hanes, J., Grizzle, W. E., Sorscher, E. J., Tearney, G. J., Rowe, S. M. Tags: CALL FOR PAPERS Source Type: research

Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis
Idiopathic pulmonary fibrosis (IPF) poses challenges to understanding its underlying cellular and molecular mechanisms and the development of better therapies. Previous studies suggest a pathophysiological role for neuraminidase 1 (NEU1), an enzyme that removes terminal sialic acid from glycoproteins. We observed increased NEU1 expression in epithelial and endothelial cells, as well as fibroblasts, in the lungs of patients with IPF compared with healthy control lungs. Recombinant adenovirus-mediated gene delivery of NEU1 to cultured primary human cells elicited profound changes in cellular phenotypes. Small airway epitheli...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Luzina, I. G., Lockatell, V., Hyun, S. W., Kopach, P., Kang, P. H., Noor, Z., Liu, A., Lillehoj, E. P., Lee, C., Miranda-Ribera, A., Todd, N. W., Goldblum, S. E., Atamas, S. P. Tags: CALL FOR PAPERS Source Type: research

Phosphatidylcholine kinetics in neonatal rat lungs and the effects of rhuKGF and betamethasone
Surfactant, synthesized by type II pneumocytes (PN-II), mainly comprises phosphatidylcholine (PC) and is essential to prevent neonatal respiratory distress. Furthermore, PC is essential to lung tissue growth and maintenance as a membrane component. Recent findings suggest that the lung contributes to systemic lipid homeostasis via PC export through ABC-A1 transporter expression. Hence it is important to consider pharmacological interventions in neonatal lung PC metabolism with respect to such export. Five-day-old rats were treated with carrier (control), intraperitoneal betamethasone, subcutaneous recombinant human keratin...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Bernhard, W., Gesche, J., Raith, M., Poets, C. F. Tags: CALL FOR PAPERS Source Type: research

Hsp90 inhibition suppresses NF-{kappa}B transcriptional activation via Sirt-2 in human lung microvascular endothelial cells
The ability of anti-heat shock protein 90 (Hsp90) drugs to attenuate NF-B-mediated transcription is the major basis for their anti-inflammatory properties. While the molecular mechanisms underlying this effect are not clear, they appear to be distinct in human endothelial cells. We now show for the first time that type 2 sirtuin (Sirt-2) histone deacetylase binds human NF-B target gene promoter and prevents the recruitment of NF-B proteins and subsequent assembly of RNA polymerase II complex in human lung microvascular endothelial cells. Hsp90 inhibitors stabilize the Sirt-2/promoter interaction and impose a "transcription...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Thangjam, G. S., Birmpas, C., Barabutis, N., Gregory, B. W., Clemens, M. A., Newton, J. R., Fulton, D., Catravas, J. D. Tags: ARTICLES Source Type: research

Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction
Calpain activation contributes to the development of infection-induced diaphragm weakness, but the mechanisms by which infections activate calpain are poorly understood. We postulated that skeletal muscle calcium-dependent phospholipase A2 (cPLA2) is activated by cytokines and has downstream effects that induce calpain activation and muscle weakness. We determined whether cPLA2 activation mediates cytokine-induced calpain activation in isolated skeletal muscle (C2C12) cells and infection-induced diaphragm weakness in mice. C2C12 cells were treated with the following: 1) vehicle; 2) cytomix (TNF-α 20 ng/ml, IL-1β...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Supinski, G. S., Alimov, A. P., Wang, L., Song, X.-H., Callahan, L. A. Tags: ARTICLES Source Type: research

Adenosine influences myeloid cells to inhibit aeroallergen sensitization
Agonists of adenosine A2A receptors (A2ARs) suppress the activation of most immune cells and reduce acute inflammatory responses. Asthma is characterized by sensitization in response to initial allergen exposure and by airway hyperreactivity in response to allergen rechallenge. We sought to determine if A2AR activation with CGS-21680 (CGS) is more effective when CGS is administered during sensitization or rechallenge. C57BL/6 wild-type mice and Adora2af/fLysMCre+/– mice, which lack A2ARs on myeloid cells, were sensitized with intranasal ovalbumin (OVA) and LPS. Airway sensitization was characterized by a rapid increa...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Pei, H., Linden, J. Tags: ARTICLES Source Type: research

Biosynthesis of the polymeric gel-forming mucin MUC5B
MUC5B is a major polymeric mucin in the airway mucus gel and is an essential component of innate defense of the respiratory epithelium. Knowledge of the synthesis and intracellular processing of MUC5B is incomplete. We investigated the molecular details of MUC5B assembly in primary human bronchial epithelial cells (HBECs) grown at an air-liquid interface (ALI). Electrophoretic and centrifugal separations of intracellular forms of MUC5B probed with antibodies specific for non-O-glycosylated and O-glycosylated forms of the mucin identified three major intracellular populations of MUC5B (non-O-glycosylated monomer and dimer, ...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Ridley, C., Kirkham, S., Williamson, S. J., Davis, C. W., Woodman, P., Thornton, D. J. Tags: ARTICLES Source Type: research

Dissecting the inflammatory twitch in allergically inflamed mice
We have previously advanced the hypothesis that the allergic inflammatory response in the lungs occurs as a self-limited sequence of events that begins with the onset of inflammation and then resolves back to baseline over a predetermined time course (Pothen JJ, Poynter ME, Bates JH. J Immunol 190: 3510–3516, 2013). In the present study we tested a key prediction of this hypothesis, which is that the instigation of the allergic inflammatory response should be accompanied by a later refractory period during which the response cannot be reinitiated. We challenged groups of ovalbumin-sensitized BALB/c mice for 3, 14, 21...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2016 Category: Respiratory Medicine Authors: Pothen, J. J., Poynter, M. E., Lundblad, L. K. A., Bates, J. H. T. Tags: ARTICLES Source Type: research

Asthma control and bronchodilator response
We thank Dr. Yeshashree Rajaure and colleagues for having appreciated our article and for their comments on it. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 15, 2016 Category: Respiratory Medicine Authors: Enrico Heffler, Nunzio Crimi Tags: Correspondence Source Type: research