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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

The role of the NLRP3 inflammasome in pulmonary diseases
This article summarizes recent research on the inflammasome and reviews proposed molecular models of the role of the inflammasome in several prominent lung diseases and injuries. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - July 14, 2015 Category: Respiratory Medicine Authors: Hosseinian, N., Cho, Y., Lockey, R. F., Kolliputi, N. Tags: Reviews Source Type: research

Cystic fibrosis transmembrane conductance regulator biomarkers in 'real life': can we evaluate individual efficacy of cystic fibrosis transmembrane conductance regulator therapy?
(Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - July 14, 2015 Category: Respiratory Medicine Authors: van Koningsbruggen-Rietschel, S., Naehrlich, L. Tags: Letter to the Editor Source Type: research

Antigen avoidance tests for diagnosis of chronic hypersensitivity pneumonitis
Conclusions It was difficult to diagnose chronic HP based solely on 2-week antigen avoidance tests; however, improved clinical parameters among patients supported the diagnosis of HP. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 14, 2015 Category: Respiratory Medicine Source Type: research

Cyclosporine A combined with low-dose corticosteroid treatment in patients with idiopathic pulmonary fibrosis
Conclusions This clinical trial revealed no significant differences between the CYA group and the CPA group with regard to either safety data or the primary endpoint. However, the trial should be regarded as inconclusive because of its small sample size. There was a trend toward a reduction in FVC decline per year when the trial groups were compared with the placebo groups of previous studies, despite patients in this study having severely impaired lung function. Both therapies were well tolerated and lacked serious adverse effects. (Source: Respiratory Investigation)
Source: Respiratory Investigation - July 14, 2015 Category: Respiratory Medicine Source Type: research

Unusual cause of haemoptysis: Inflammatory myofibroblastic tumour of the lung
Publication date: Available online 14 July 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): A. Araújo , W. Xiaogang , D. Tente , M. Figueiredo (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 14, 2015 Category: Respiratory Medicine Source Type: research

Identification of a mitochondrial defect gene signature reveals NUPR1 as a key regulator of liver cancer progression
Conclusion: We suggest that mitochondrial respiratory defects and subsequent retrograde signaling, particularly the NUPR1‐GRN pathway, play pivotal roles in liver cancer progression. This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - July 14, 2015 Category: Internal Medicine Authors: Young‐Kyoung Lee, Byul A Jee, So Mee Kwon, Young‐Sil Yoon, Wei Guang Xu, Hee‐Jung Wang, Xin Wei Wang, Snorri S. Thorgeirsson, Jae‐Seon Lee, Hyun Goo Woo, Gyesoon Yoon Tags: Hepatology Elsewhere Source Type: research

The potential health challenges of TiO2 nanomaterials
Abstract Titanium dioxide (TiO2) nanomaterials (NMs) have found widespread applications owing to their attractive physical and chemical properties. As a result, the potential adverse impacts of nano‐TiO2 exposure on humans have become a matter of concern. This review presents the state‐of‐the‐art advances on the investigations of the adverse effects of NMs, including the potential exposure routes of nano‐TiO2 (e.g. respiratory system, skin absorption and digestive system), the physico‐chemical characterizations of nano‐TiO2 (e.g. crystal structure, shape,size, zeta potential, treatment media, aggregation and ...
Source: Journal of Applied Toxicology - July 14, 2015 Category: Toxicology Authors: Baoyong Sha, Wei Gao, Xingye Cui, Lin Wang, Feng Xu Tags: Review article Source Type: research

Effects of Adjuvant Systems on the cardiovascular and respiratory functions in telemetered conscious dogs and anaesthetised rats
Publication date: October 2015 Source:Regulatory Toxicology and Pharmacology, Volume 73, Issue 1 Author(s): Lawrence Segal , Virginie Roger , Colin Williams , Eric Destexhe , Nathalie Garçon Adjuvants Systems (AS) containing immunostimulant combinations are used in human vaccines. Safety pharmacology studies evaluated the cardiorespiratory effects of AS in conscious telemetered dogs and in anaesthetised rats. Sixteen telemetered beagle dogs (4/group) received intramuscular injections of saline at Day 0, and one clinical dose of AS01, AS03, AS04 or AS15 at Day 7 (7× the equivalent human dose on a bodyweight basis). Body...
Source: Regulatory Toxicology and Pharmacology - July 14, 2015 Category: Toxicology Source Type: research

Biodegradable nanoparticles for lung gene therapy [Medical Sciences]
Gene therapy has emerged as an alternative for the treatment of diseases refractory to conventional therapeutics. Synthetic nanoparticle-based gene delivery systems offer highly tunable platforms for the delivery of therapeutic genes. However, the inability to achieve sustained, high-level transgene expression in vivo presents a significant hurdle. The respiratory system, although... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - July 14, 2015 Category: Science Authors: Mastorakos, P., da Silva, A. L., Chisholm, J., Song, E., Choi, W. K., Boyle, M. P., Morales, M. M., Hanes, J., Suk, J. S. Tags: Biological Sciences Source Type: research

Early life exposure to chronic intermittent hypoxia causes upper airway dilator muscle weakness, which persists into young adulthood
New Findings What is the central question of this study? Chronic intermittent hypoxia (CIH) is a dominant feature of respiratory control disorders, which are common. We sought to examine the effects of exposure to CIH during neonatal development on respiratory muscle form and function in male and female rats. What is the main finding and its importance? Exposure to CIH during neonatal development caused sternohyoid muscle weakness in both sexes; an effect that persisted into young adult life upon return to normoxia. Upper airway dilator muscle dysfunction in vivo could predispose to airway collapse, leading to impaired ...
Source: Experimental Physiology - July 14, 2015 Category: Physiology Authors: Fiona B. McDonald, Robert Williams, David Sheehan, Ken D. O'Halloran Tags: Research Paper Source Type: research

Healthy Late-preterm infants born 33–36+6 weeks gestational age have higher risk for respiratory syncytial virus hospitalization
Respiratory syncytial virus (RSV) is a leading cause of hospitalization for children (Source: Early Human Development)
Source: Early Human Development - July 14, 2015 Category: Perinatology & Neonatology Authors: Alison M. Helfrich, Cade M. Nylund, Matthew D. Eberly, Matilda B. Eide, David R. Stagliano Source Type: research

The Role of Surfactant Therapy in Nonrespiratory Distress Syndrome Conditions in Neonates
Amer J PerinatolDOI: 10.1055/s-0035-1556883While treatment of respiratory distress syndrome (RDS) with surfactant in premature neonates is well established, evidence for its use in non-RDS conditions, especially in the term neonate, has been less abundant. The last published review on a PubMed search was in 2001. In this review, we comprehensively and critically evaluated the evidence from the literature regarding the use of surfactant in specific non-RDS disorders in neonates. Surfactant administered as a bolus should be considered in the treatment of meconium aspiration syndrome with progressive respiratory failure. Whil...
Source: American Journal of Perinatology - July 14, 2015 Category: Perinatology & Neonatology Authors: Keiser, AmarisBhandari, Vineet Tags: Topical Review Source Type: research

Absence of Capsule Reveals Glycan‐Mediated Binding and Recognition of Salivary Mucin MUC7 by Streptococcus pneumoniae
This article is protected by copyright. All rights reserved. (Source: Oral Microbiology and Immunology)
Source: Oral Microbiology and Immunology - July 14, 2015 Category: Microbiology Authors: Supaporn Thamadilok, Hazeline Roche‐Håkansson, Anders P. Håkansson, Stefan Ruhl Tags: Original Article Source Type: research

Type‐II NADH:quinone oxidoreductase from Staphylococcus aureus has two distinct binding sites and is rate limited by quinone reduction
We report fast kinetic analyses of the protein and detected a charge‐transfer complex formed between NAD+ and the reduced flavin, which is dissociated by the quinone. We observed that the quinone reduction is the rate limiting step and also the only half‐reaction affected by the presence of HQNO, an inhibitor. We analyzed protein‐substrate interactions by fluorescence and STD‐NMR spectroscopies, which indicate that NADH and the quinone bind to different sites. In summary, our combined results show the presence of distinct binding sites for the two substrates, identified quinone reduction as the rate limiting step...
Source: Molecular Microbiology - July 14, 2015 Category: Microbiology Authors: Filipa V. Sena, Ana P. Batista, Teresa Catarino, José A. Brito, Margarida Archer, Martin Viertler, Tobias Madl, Eurico J. Cabrita, Manuela M. Pereira Tags: Research Article Source Type: research

Modified chemically defined medium for enhanced respiratory growth of Lactobacillus casei and L. plantarum groups
ConclusionsThe nutritional requirements of anaerobic and respiratory cultures of members of the L. casei and L. plantarum groups differ. Tween 80 and selected amino acids derived from pathways related to TCA cycle, pyruvate conversion and NADH recycling are required for respiration. Significance and Impact of the StudyThe availability of mCDM will facilitate the study of aerobic metabolism of lactobacilli under controlled conditions.This article is protected by copyright. All rights reserved. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - July 14, 2015 Category: Microbiology Authors: Annamaria Ricciardi, Rocco G. Ianniello, Eugenio Parente, Teresa Zotta Tags: Original Article Source Type: research

Serum concentrations of allergen‐specific IgE in horses with equine recurrent airway obstruction and healthy controls assessed by ELISA
ConclusionOn the basis of our observations and results, we conclude that RAO is associated with increased serum concentrations of specific serum IgE against mites, in particular T putrescentia. (Source: Veterinary Clinical Pathology)
Source: Veterinary Clinical Pathology - July 14, 2015 Category: Veterinary Research Authors: Artur Niedzwiedz, Zbigniew Jaworski, Krzysztof Kubiak Tags: Brief Communication Source Type: research

Multiplex analysis of pro-inflammatory cytokines in serum of Actinobacillus pleuropneumoniae-infected pigs
Publication date: Available online 14 July 2015 Source:Research in Veterinary Science Author(s): H. Wyns , S. Croubels , M. Vandekerckhove , K. Demeyere , P. De Backer , B.M. Goddeeris , E. Meyer Porcine pleuropneumonia is a severe respiratory disease caused by Actinobacillus (A.) pleuropneumoniae. The aim of the present study was to analyze serum samples of A. pleuropneumoniae-infected pigs for TNF-α, IL-1β and IL-6 using a cytometric bead array (CBA) 3-plex assay and additionally for IL-6 using ELISA. The CBA 3-plex assay was successfully validated for use in serum. The limits of detection varied between 0.012 and 0....
Source: Research in Veterinary Science - July 14, 2015 Category: Veterinary Research Source Type: research

Respiratory syncytial virus is present in the neonatal intensive care unit
This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - July 14, 2015 Category: Virology Authors: Nusrat Homaira, Joanne Sheils, Sacha Stelzer‐Braid, Kei Lui, Ju‐Lee Oie, Tom Snelling, Adam Jaffe, William Rawlinson Tags: Research Article Source Type: research

Hypoxic preconditioning enhances mesenchymal stromal cell lung repair capacity
Idiopathic pulmonary fibrosis is a progressive, irreversible, debilitating, and fatal lung disease, characterized by parenchymal fibrosis with reduced lung volumes and respiratory failure. No lasting option for therapy is available other than transplantation. Mesenchymal stem/stromal cells home to sites of injury, decrease inflammation, have antifibrotic properties, and promote epithelial tissue repair, so their use has been suggested as potential therapy for idiopathic pulmonary fibrosis. Despite reported benefits, the amount of mesenchymal stromal cells engrafting to the lung decreases substantially soon after administra...
Source: Stem Cell Research and Therapy - July 14, 2015 Category: Stem Cells Authors: Fernanda CruzPatricia Rocco Source Type: research

Immune deficiency: changing spectrum of pathogens
Summary Current UK national standards recommend routine bacteriology surveillance in severe antibody‐deficient patients, but less guidance exists on virology screening and viral infections in these patients. In this retrospective audit, we assessed the proportion of positive virology or bacteriology respiratory and stool samples from patients with severe, partial or no immune deficiency during a 2‐year period. Medical notes were reviewed to identify symptomatic viral infections and to describe the course of persistent viral infections. During the 2‐year period, 31 of 78 (39·7%) severe immune‐deficient patients tes...
Source: Clinical and Experimental Immunology - July 14, 2015 Category: Allergy & Immunology Authors: S. S. Duraisingham, A. Manson, S. Grigoriadou, M. Buckland, C. Y. W. Tong, H. J. Longhurst Tags: Translational Source Type: research

Integrated non‐invasive measurements reveal swallowing and respiration coordination recovery after unilateral stroke
Conclusions & InferencesThe non‐invasive swallowing and respiration assessment method applied in this study detected the changes manifested in swallowing and respiration during the subacute phase of recovery in 6 months after a unilateral stroke. The study results serve as a baseline for further research and help advance dysphagia research methodologies. These assessments may be combined with bedside evaluations for clinical application. A non‐invasive swallowing assessment method was used to detect oropharyngeal swallowing parameters and respiration coordination simultaneously during the swallowing process. Resu...
Source: Neurogastroenterology and Motility - July 14, 2015 Category: Gastroenterology Authors: C.‐M. Wang, W.‐Y. Shieh, J.‐Y. Chen, Y.‐R. Wu Tags: Original Article Source Type: research

Middle East respiratory syndrome coronavirus (MERS-CoV): A cluster analysis with implications for global management of suspected cases
In this report, we describe the outcome, epidemiology and clinical characteristics of this cluster of which 4 cases involved health care workers. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - July 14, 2015 Category: Infectious Diseases Authors: Ziad A. Memish, Jaffar A. Al-Tawfiq, Rafat F. Alhakeem, Abdullah Assiri, Khalid D. Alharby, Maher S. Almahallawi, Mohammed Alkhallawi Source Type: research

Respiratory and neurological disease in rabbits experimentally infected with equid herpesvirus 1
Publication date: Available online 14 July 2015 Source:Microbial Pathogenesis Author(s): Fábio A. Kanitz , Juliana F. Cargnelutti , Deniz Anziliero , Kelley V. Gonçalves , Eduardo K. Masuda , Rudi Weiblen , Eduardo F. Flores Equid herpesvirus type 1 (EHV-1) is an important pathogen of horses worldwide, associated with respiratory, reproductive and/or neurological disease. A mouse model for EHV-1 infection has been established but fails to reproduce some important aspects of the viral pathogenesis. Then, we investigated the susceptibility of rabbits to EHV-1 aiming at proposing this species as an alternative model for E...
Source: Microbial Pathogenesis - July 14, 2015 Category: Infectious Diseases Source Type: research

Barriers to uptake among high-risk individuals declining participation in lung cancer screening: a mixed methods analysis of the UK Lung Cancer Screening (UKLS) trial
Conclusions A profile of risk factors for non-participation in lung screening has emerged, with underlying reasons largely relating to practical and emotional barriers. Strategies for engaging high-risk, hard-to-reach groups are critical for the equitable uptake of a potential future lung cancer screening programme. Trial registration number The UKLS trial was registered with the International Standard Randomised Controlled Trial Register under the reference 78513845. (Source: BMJ Open)
Source: BMJ Open - July 14, 2015 Category: Journals (General) Authors: Ali, N., Lifford, K. J., Carter, B., McRonald, F., Yadegarfar, G., Baldwin, D. R., Weller, D., Hansell, D. M., Duffy, S. W., Field, J. K., Brain, K. Tags: Open access, Health services research, Respiratory medicine Source Type: research

Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity
We examined effects of acidosis, hypocretin-1, a hypocretin receptor antagonist (SB-408124), and the effect of the antagonist on the response to acidosis. We confirmed the critical role of 5-HT neurons in central chemosensitivity given that the increased hypoglossal burst frequency with acidosis, characteristic of WT mice, was absent in preparations derived from Lmx1bf/f/p mice. We also found that hypocretin facilitated baseline neural ventilatory output in part through 5-HT neurons. Although the impact of hypocretin on 5-HT neuronal sensitivity to acidosis is still unclear, hypocretins did appear to mediate the burst dura...
Source: Journal of Neurophysiology - July 14, 2015 Category: Neurology Authors: Corcoran, A. E., Richerson, G. B., Harris, M. B. Tags: Control Of Homeostasis Source Type: research

Respiratory problems in children with neurodisability
Respiratory problems are very common in children with neurodisability being the most common cause of higher morbidity and death. The factors that contribute to these difficulties include poor cough and pooling of oropharyngeal sections. Gastro-oesophageal reflux, muscle weakness and development of kyphoscoliosis lead to chronic ongoing morbidity leading to recurrent infections and development of bronchiectasis. Obstructive sleep problems may require mechanical support. Common paediatric conditions such as asthma may co-exist. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - July 14, 2015 Category: Pediatrics Authors: M. Hurley, Harish Vyas Tags: Symposium: special needs Source Type: research

Clinical Reasoning and Risk in the Intensive Care Unit
Clinical reasoning in medicine describes the process whereby a clinician gathers, assimilates, and assesses information about a person and their illness to assign a diagnosis and institute therapy. Care of patients in the intensive care unit involves managing a substantial quantity of incomplete, novel, and rapidly changing data. A modified nine-step bayesian approach to clinical reasoning comports well with this complex environment and is useful for assisting and educating novice learners to apply clinical reasoning accurately and consistently. When combined with a sophisticated approach to risk-benefit analysis to modify...
Source: Clinics in Chest Medicine - July 14, 2015 Category: Respiratory Medicine Authors: Geoffrey R. Connors, Jonathan M. Siner Source Type: research

Nebulized fluticasone propionate, a viable alternative to systemic route in the management of childhood moderate asthma attack: A double-blind, double-dummy study
In this study, we compared the clinical and immunological efficacy of nebulized corticosteroid (CS) to systemic route during treatment of moderate asthma attack in children. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 14, 2015 Category: Respiratory Medicine Authors: Beyza Poplata Demirca, Hasret Cagan, Ayca Kiykim, Ulku Arig, Medeni Arpa, Aysin Tulunay, Ahmet Ozen, Elif Karakoc – Aydiner, Safa Baris, I.B. Barlan Source Type: research

Red blood cell distribution width [RDW] and long-term mortality after community-acquired pneumonia. A comparison with proadrenomedullin
Proadrenomedullin (proADM), a cardiovascular biomarker, has shown high prognostic power for community-acquired pneumonia (CAP) outcomes. Red-blood-cell distribution width (RDW), linked to cardiovascular disorders, has been associated with short-term and medium-term mortality after CAP. Our objective was to assess the accuracy of both biomarkers for CAP long-term mortality (>90 days).Adults hospitalized with CAP underwent blood proADM, RDW, C-reactive protein (CRP) and procalcitonin (PCT) measurements at admission, and were evaluated after 30, 90, and 180 days, and 1, 2, and 3 years, until either death or 5 years of follow-...
Source: Respiratory Medicine CME - July 14, 2015 Category: Respiratory Medicine Authors: S. Bello, S. Fandos, A.B. Lasierra, E. Mincholé, C. Panadero, A.L. Simon, O. Gavin, F. De Pablo, R. Menendez, A. Torres Source Type: research

Reliability, validity and responsiveness to change of the Saint George's Respiratory Questionnaire in early diffuse cutaneous systemic sclerosis
Conclusion. The SGRQ has acceptable reliability, construct validity and responsiveness to change for use in a dcSSc population and differentiates between patients with and without ILD. (Source: Rheumatology)
Source: Rheumatology - July 14, 2015 Category: Rheumatology Authors: Wallace, B., Kafaja, S., Furst, D. E., Berrocal, V. J., Merkel, P. A., Seibold, J. R., Mayes, M. D., Khanna, D. Tags: Systemic Sclerosis CLINICAL SCIENCE Source Type: research

Lung cancer-a fractal viewpoint.
We describe the fractal nature of the lung and explain why this organ is particularly suited to fractal analysis. Studies that have used fractal analyses to quantify changes in nuclear and chromatin FD in primary and metastatic tumour cells, and clinical imaging studies that correlated changes in the FD of tumours on CT and/or PET images with tumour growth and treatment responses are reviewed. Moreover, the potential use of these techniques in the diagnosis and therapeutic management of lung cancer are discussed. PMID: 26169924 [PubMed - as supplied by publisher] (Source: Clinical Lung Cancer)
Source: Clinical Lung Cancer - July 14, 2015 Category: Cancer & Oncology Authors: Lennon FE, Cianci GC, Cipriani NA, Hensing TA, Zhang HJ, Chen CT, Murgu SD, Vokes EE, Vannier MW, Salgia R Tags: Nat Rev Clin Oncol Source Type: research

Perilipin 3 Differentially Regulates Skeletal Muscle Lipid Oxidation in Active, Sedentary and Type 2 Diabetic Males.
CONCLUSIONS: Differential expression of PLIN3 and BFA sensitivity may explain differential lipid oxidation efficiency in skeletal muscle among these cohorts. PMID: 26171795 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - July 14, 2015 Category: Endocrinology Authors: Covington JD, Noland RC, Hebert RC, Masinter BS, Smith SR, Rustan AC, Ravussin E, Bajpeyi S Tags: J Clin Endocrinol Metab Source Type: research

Interventions for bronchiectasis: an overview of Cochrane systematic reviews.
CONCLUSIONS: This overview clearly points to significant opportunities for further research aimed at improving outcomes for people with bronchiectasis. We have highlighted important endpoints for studies (particularly exacerbations, quality of life and lung function), and areas of clinical practice that are in most urgent need of evidence-based support (including long-term antibiotics, ICSs and mucolytics).As the evidence is confined to small trials of short duration, it is not currently possible to assess the balance between the benefits and potential harms of treatments for bronchiectasis. PMID: 26171905 [PubMed - as...
Source: Cochrane Database of Systematic Reviews - July 14, 2015 Category: Journals (General) Authors: Welsh EJ, Evans DJ, Fowler SJ, Spencer S Tags: Cochrane Database Syst Rev Source Type: research

Computed tomographic assessment of airflow obstruction in smoke inhalation injury: Relationship with the development of pneumonia and injury severity
Smoke inhalation injury (SII) contributes to the development of pulmonary edema, pneumonia, and acute respiratory distress syndrome (ARDS) [1]. In a burn patient, if SII is present, treatment strategy needs to be revised because of the present respiratory deterioration [2]. The prediction of pulmonary deterioration in patients with SII using presently available examinations such as bronchoscopy, laboratory data, and chest X-rays is difficult [3–9]. Recently, Kwon et al. reported that virtual bronchoscopy by computed tomography was useful in the determination of SII severity [10]. (Source: Burns : Journal of the Internati...
Source: Burns : Journal of the International Society for Burn Injuries - July 14, 2015 Category: Cosmetic Surgery Authors: Hitoshi Yamamura, Takasei Morioka, Naohiro Hagawa, Tomonori Yamamoto, Yasumitsu Mizobata Source Type: research

Obstructive sleep apnea syndrome: coagulation anomalies and treatment with continuous positive airway pressure
Conclusion Further studies are required to determine the precise role of hypercoagulability in the cardiovascular pathogenesis of OSAS, particularly its interaction with oxidative stress, thrombotic tendency and endothelial dysfunction. Nasal continuous positive airway pressure (nCPAP), the gold standard treatment for OSAS, not only significantly reduced apnea-hypopnoea indices but also markers of hypercoagulability, thus representing a potential mechanisms by which CPAP reduces the rate of cardiovascular morbidity and mortality in OSAS patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 14, 2015 Category: Respiratory Medicine Source Type: research

Capnography monitoring during procedural sedation and analgesia: a systematic review protocol
Discussion This review will synthesise the evidence on an important potential clinical benefit of capnography monitoring during PSA within hospital settings. Systematic review registration PROSPERO CRD42015023740 (Source: Systematic Reviews)
Source: Systematic Reviews - July 14, 2015 Category: Global & Universal Source Type: research

Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization
Abstract The prevalence of allergic airway diseases such as asthma and rhinitis has increased dramatically to epidemic proportions worldwide. Besides air pollution from industry derived emissions and motor vehicles, the rising trend can only be explained by gross changes in the environments where we live. The world economy has been transformed over the last 25 years with developing countries being at the core of these changes. Around the planet, in both developed and developing countries, environments are undergoing profound changes. Many of these changes are considered to have negative effects on respiratory he...
Source: World Allergy Organization Journal - July 14, 2015 Category: Allergy & Immunology Source Type: research

Higher oesophageal temperature at rest and during exercise in humans with patent foramen ovale.
This article is protected by copyright. All rights reserved. PMID: 26173096 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 14, 2015 Category: Physiology Authors: Davis JT, Ng CA, Hill SD, Padgett RC, Lovering AT Tags: J Physiol Source Type: research

Peripheral chemoreceptors determine the respiratory sensitivity of central chemoreceptors to CO2 : Role of carotid body CO2.
This article is protected by copyright. All rights reserved. PMID: 26171601 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 14, 2015 Category: Physiology Authors: Smith CA, Blain GM, Henderson KS, Dempsey JA Tags: J Physiol Source Type: research

The Feasibility of Extracorporeal Membrane Oxygenation in the Variant Airway Problems.
CONCLUSION: ECMO is useful during anesthesia in patients at high risk of airway blockade, for example due to endobronchial bleeding, and during complex thoracic surgery. ECMO confers a safer environment during airway surgery, and its complication rate is acceptable. PMID: 26179424 [PubMed - as supplied by publisher] (Source: Annals of Thoracic and Cardiovascular Surgery)
Source: Annals of Thoracic and Cardiovascular Surgery - July 14, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Kim CW, Kim DH, Son BS, Cho JS, Kim YD, I H, Ahn HY Tags: Ann Thorac Cardiovasc Surg Source Type: research

Deletion of nuclear factor-κB p50 upregulates fatty acid utilization and contributes to an anti-obesity and high-endurance phenotype in mice.
Abstract The transcription factor nuclear factor-kappa B (NF-κB) plays an important role in regulating physiological process such as immunity and inflammation. In addition to this primary role, NF-κB interacts physically with peroxisome proliferator-activated receptors regulating lipid metabolism-related gene expression and inhibits their transcriptional activity. Inhibition of NF-κB may, therefore, promote fatty acid utilization, which could ameliorate obesity and improve endurance capacity. To test this hypothesis, we attempted to elucidate the energy metabolic status of mice lacking the p50 subunit of NF-κB ...
Source: American Journal of Physiology. Endocrinology and Metabolism - July 14, 2015 Category: Physiology Authors: Minegishi Y, Haramizu S, Misawa K, Shimotoyodome A, Hase T, Murase T Tags: Am J Physiol Endocrinol Metab Source Type: research

Mitochondrial respiratory chain defects in skin fibroblasts from patients with Dravet syndrome
(Source: Neurological Sciences)
Source: Neurological Sciences - July 14, 2015 Category: Neurology Source Type: research

Safety and efficacy of carbon dioxide insufflation during gastric endoscopic submucosal dissection.
CONCLUSION: CO2 insufflation during gastric ESD results in similar blood gas levels as air insufflation, and also reduces the incidence of Mallory-Weiss tears. PMID: 26185394 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - July 14, 2015 Category: Gastroenterology Authors: Takada J, Araki H, Onogi F, Nakanishi T, Kubota M, Ibuka T, Shimizu M, Moriwaki H Tags: World J Gastroenterol Source Type: research

Neural and Glial Progenitor Transplantation as a Neuroprotective Strategy for Amyotrophic Lateral Sclerosis (ALS).
Abstract ALS is a neurodegenerative disease with a prevalence rate of up to 7.4/100,000 and the overall risk of developing ALS over a lifetime is 1:400. Most patients die from respiratory failure following a course of progressive weakness. To date, only one traditional pharmaceutical agent-riluzole, has been shown to afford a benefit on survival but numerous pharmaceutical interventions have been studied in preclinical models of ALS without subsequent translation to patient efficacy. Despite the relative selectivity of motor neuron cell death, animal and tissue culture models of familial ALS suggest that non-neuron...
Source: Brain Research - July 14, 2015 Category: Neurology Authors: Haidet-Phillips AM, Maragakis NJ Tags: Brain Res Source Type: research