Medicine RSS Search Engine

Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Early right ventricular fibrosis and reduction in biventricular cardiac reserve in the dystrophin-deficient mdx heart
Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant because they result in the leading causes of death in DMD patients. Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in DMD. We show here that prior to the onset of global cardiac dysfunction, dystrophin-deficient mdx mice have increased cardiac fibrosis with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization techni...
Source: AJP: Heart and Circulatory Physiology - February 15, 2015 Category: Cardiology Authors: Meyers, T. A., Townsend, D. Tags: MUSCLE MECHANICS AND VENTRICULAR FUNCTION Source Type: research

Ebola: history, treatment, and lessons from a new emerging pathogen
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Harrod, K. S. Tags: CALL FOR PAPERS Source Type: research

Vasculopathy and pulmonary hypertension in sickle cell disease
Sickle cell disease (SCD) is an autosomal recessive disorder in the gene encoding the β-chain of hemoglobin. Deoxygenation causes the mutant hemoglobin S to polymerize, resulting in rigid, adherent red blood cells that are entrapped in the microcirculation and hemolyze. Cardinal features include severe painful crises and episodic acute lung injury, called acute chest syndrome. This population, with age, develops chronic organ injury, such as chronic kidney disease and pulmonary hypertension. A major risk factor for developing chronic organ injury is hemolytic anemia, which releases red blood cell contents into the cir...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Potoka, K. P., Gladwin, M. T. Tags: PHYSIOLOGY IN MEDICINE Source Type: research

ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets
Acute and chronic lung inflammation is driven and controlled by several endogenous mediators that undergo proteolytic conversion from surface-expressed proteins to soluble variants by a disintegrin and metalloproteinase (ADAM)-family members. TNF and epidermal growth factor receptor ligands are just some of the many substrates by which these proteases regulate inflammatory or regenerative processes in the lung. ADAM10 and ADAM17 are the most prominent members of this protease family. They are constitutively expressed in most lung cells and, as recent research has shown, are the pivotal shedding enzymes mediating acute lung...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Dreymueller, D., Uhlig, S., Ludwig, A. Tags: CALL FOR PAPERS Source Type: research

Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis
Pathological fibrosis is driven by a feedback loop in which the fibrotic extracellular matrix is both a cause and consequence of fibroblast activation. However, the molecular mechanisms underlying this process remain poorly understood. Here we identify yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis. YAP and TAZ are prominently expressed in fibrotic but not healthy lung tissue, with particular...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Liu, F., Lagares, D., Choi, K. M., Stopfer, L., Marinkovic, A., Vrbanac, V., Probst, C. K., Hiemer, S. E., Sisson, T. H., Horowitz, J. C., Rosas, I. O., Fredenburgh, L. E., Feghali-Bostwick, C., Varelas, X., Tager, A. M., Tschumperlin, D. J. Tags: CALL FOR PAPERS Source Type: research

Distinct macrophage phenotypes in allergic and nonallergic lung inflammation
In this study, we aimed to characterize and quantify the lung macrophage populations in two established murine models of allergic and nonallergic lung inflammation by means of fluorescence-activated cell sorting and immunohistochemistry. We demonstrated that, whereas in allergic asthma M2-dominant macrophages predominated in the lungs, in nonallergic inflammation M1-dominant macrophages were more prevalent. This was confirmed in vitro using a macrophage cell line, where FDE exerted a direct effect on macrophages, inducing M1-dominant polarization. The polarization of macrophages diverged depending on the exposure and infla...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Robbe, P., Draijer, C., Borg, T. R., Luinge, M., Timens, W., Wouters, I. M., Melgert, B. N., Hylkema, M. N. Tags: CALL FOR PAPERS Source Type: research

Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia
Endothelin-1 (ET-1) increases pulmonary vascular tone through direct effects on pulmonary artery smooth muscle cells (PASMC) via membrane-bound ET-1 receptors. Circulating ET-1 contributes to vascular remodeling by promoting SMC proliferation and migration and inhibiting SMC apoptosis. Although endothelial cells (EC) are the primary source of ET-1, whether ET-1 produced by SMC modulates pulmonary vascular tone is unknown. Using transgenic mice created by crossbreeding SM22α-Cre mice with ET-1 flox/flox mice to selectively delete ET-1 in SMC, we tested the hypothesis that PASMC ET-1 gene expression modulates the pulmo...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Kim, F. Y., Barnes, E. A., Ying, L., Chen, C., Lee, L., Alvira, C. M., Cornfield, D. N. Tags: CALL FOR PAPERS Source Type: research

Plasma vascular endothelial growth factor A and placental growth factor: novel biomarkers of pulmonary hypertension in congenital diaphragmatic hernia
Pulmonary hypertension (PH) due to abnormal pulmonary vascular development is an important determinant of illness severity in congenital diaphragmatic hernia (CDH). Vascular endothelial growth factor A (VEGFA) and placental growth factor (PLGF) may be important mediators of pulmonary vascular development in health and disease. This prospective study investigated the relationship between plasma VEGFA and PLGF and measures of pulmonary artery pressure, oxygenation, and cardiac function in CDH. A cohort of 10 infants with CDH consecutively admitted to a surgical neonatal intensive care unit (NICU) was recruited. Eighty serial...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Patel, N., Moenkemeyer, F., Germano, S., Cheung, M. M. H. Tags: CALL FOR PAPERS Source Type: research

A computational model of unresolved allergic inflammation in chronic asthma
We have previously developed an agent-based computational model to demonstrate the feasibility of a novel hypothesis we term the inflammatory twitch. This hypothesis potentially explains the dynamics of the normal response to allergic inflammation in the lung (Pothen JJ, Poynter ME, Bates JH. J Immunol 190: 3510–3516, 2013) on the basis that antigenic stimulation sets in motion both the onset of inflammation and its subsequent resolution. The result is a self-limited inflammatory event that is similar in a formal sense to a skeletal muscle twitch. We hypothesize here that the chronic airway inflammation characteristi...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Pothen, J. J., Poynter, M. E., Bates, J. H. T. Tags: ARTICLES Source Type: research

LGL1 modulates proliferation, apoptosis, and migration of human fetal lung fibroblasts
Rapid growth and formation of new gas exchange units (alveogenesis) are hallmarks of the perinatal lung. Bronchopulmonary dysplasia (BPD), common in very premature infants, is characterized by premature arrest of alveogenesis. Mesenchymal cells (fibroblasts) regulate both lung branching and alveogenesis through mesenchymal-epithelial interactions. Temporal or spatial deficiency of late-gestation lung 1/cysteine-rich secretory protein LD2 (LGL1/CRISPLD2), expressed in and secreted by lung fibroblasts, can impair both lung branching and alveogenesis (LGL1 denotes late gestation lung 1 protein; LGL1 denotes the human gene; Lg...
Source: AJP: Lung Cellular and Molecular Physiology - February 15, 2015 Category: Respiratory Medicine Authors: Zhang, H., Sweezey, N. B., Kaplan, F. Tags: ARTICLES Source Type: research

Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
Conclusions: SP-D is expressed differently in airways of asthmatics relative to that of non-asthmatics. This can have implications on the increased susceptibility to infections and altered inflammatory response in asthmatic patients. Future functional studies on the role of SP-D in asthma can provide better insight into defects in the structure and regulation of SP-D. (Source: Respiratory Research)
Source: Respiratory Research - February 15, 2015 Category: Respiratory Medicine Authors: Jie XuGurpreet SingheraDelbert Dorscheid Source Type: research

Once-daily fluticasone furoate/vilanterol 100/25mcg versus twice daily combination therapies in COPD ¿ mixed treatment comparisons of clinical efficacy
Conclusions: FF/VI 100/25mcg was comparable with corresponding doses of FP/SAL and BUD/FORM on lung function and health status outcomes. Non-inferiority on moderate/severe exacerbation rate was not demonstrated to the same degree of confidence, though observed rates were similar. Model limitations include a weak treatment network for the exacerbation analysis and variability across the included studies. Our data support previous RCT findings suggesting that the efficacy of FF/VI 100/25mcg on lung function and health status in COPD is comparable with twice-daily ICS/LABAs. (Source: Respiratory Research)
Source: Respiratory Research - February 15, 2015 Category: Respiratory Medicine Authors: Gillian StynesHenrik SvedsaterJaro WexSally LettisDavid LeatherEmanuela CastelnuovoMichelle DetryScott Berry Source Type: research

Jean-Antoine Villemin: ending an alpine divide
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - February 15, 2015 Category: Respiratory Medicine Authors: Rieder, Hans L. Tags: EDITORIALS Source Type: research

Copper Sulphate Reduces the Metabolic Activity of Gammarus fossarum in Laboratory and Field Experiments
Publication date: Available online 13 February 2015 Source:Aquatic Toxicology Author(s): Lara Schmidlin , Stefanie von Fumetti , Peter Nagel The specialised fauna of freshwater springs is affected by contamination of the water with xenobiotics from human activities in the surrounding landscape. We assessed the effects of exposure to toxins in laboratory and field experiments by using copper sulphate as a model substance and Gammarus fossarum Koch, 1836, as the model organism. This amphipod is a common representative of the European spring fauna and copper is a widespread contaminant, mainly from agricultural practice. Th...
Source: Aquatic Toxicology - February 15, 2015 Category: Toxicology Source Type: research

Acute intermittent optogenetic stimulation of nucleus tractus solitarius neurons induces sympathetic long-term facilitation
Acute intermittent hypoxia (AIH) induces sympathetic and phrenic long-term facilitation (LTF), defined as a sustained increase in nerve discharge. We investigated the effects of AIH and acute intermittent optogenetic (AIO) stimulation of neurons labeled with AAV-CaMKIIa, hChR2(H134R), and mCherry in the nucleus of the solitary tract (NTS) of anesthetized, vagotomized, and mechanically ventilated rats. We measured renal sympathetic nerve activity (RSNA), phrenic nerve activity (PNA), power spectral density, and coherence, and we made cross-correlation measurements to determine how AIO stimulation and AIH affected synchroniz...
Source: AJP: Regulatory, Integrative and Comparative Physiology - February 15, 2015 Category: Physiology Authors: Yamamoto, K., Lalley, P., Mifflin, S. Tags: Respiration Source Type: research

Respiratory cortical processing to inspiratory resistances during wakefulness in children with the obstructive sleep apnea syndrome
Children with the obstructive sleep apnea syndrome (OSAS) have impaired respiratory afferent cortical processing during sleep that persists after treatment of OSAS. However, it is unknown whether this impairment is present during wakefulness and, if so, whether it improves after OSAS treatment. We hypothesized that children with OSAS, during wakefulness, have abnormal cortical processing of respiratory stimuli manifested by blunted respiratory-related evoked potentials (RREP) and that this resolves after OSAS treatment. We measured RREP during wakefulness in 26 controls and 21 children with OSAS before and after treatment....
Source: Journal of Applied Physiology - February 15, 2015 Category: Physiology Authors: Tapia, I. E., McDonough, J. M., Huang, J., Marcus, C. L., Gallagher, P. R., Shults, J., Davenport, P. W. Tags: ARTICLES Source Type: research

Effect of inhaled carbon dioxide on laryngeal abduction
Hypercapnia produces a profound effect on respiratory drive and upper airway function to maintain airway patency. Previous work has evaluated the effects of hypercapnia on the sole arytenoid abductor, the posterior cricoarytenoid (PCA), using indirect measures of function, such as electromyography and direct nerve recording. Here we describe a novel method to evaluate PCA function in anesthetized animals and use this method to determine the effects of hypercapnia on PCA function. Eight dogs were anesthetized, and a laryngeal mask airway was used, in combination with high-speed videoendoscopy, to evaluate laryngeal function...
Source: Journal of Applied Physiology - February 15, 2015 Category: Physiology Authors: Cheetham, J., Jones, A., Martin-Flores, M. Tags: INNOVATIVE METHODOLOGY Source Type: research

HCN channels contribute to serotonergic modulation of ventral surface chemosensitive neurons and respiratory activity
Chemosensitive neurons in the retrotrapezoid nucleus (RTN) provide a CO2/H+-dependent drive to breathe and function as an integration center for the respiratory network, including serotonergic raphe neurons. We recently showed that serotonergic modulation of RTN chemoreceptors involved inhibition of KCNQ channels and activation of an unknown inward current. Hyperpolarization-activated cyclic-nucleotide-gated (HCN) channels are the molecular correlate of the hyperpolarization-activated inward current (Ih) and have a high propensity for modulation by serotonin. To investigate whether HCN channels contribute to basal activity...
Source: Journal of Neurophysiology - February 15, 2015 Category: Neurology Authors: Hawkins, V. E., Hawryluk, J. M., Takakura, A. C., Tzingounis, A. V., Moreira, T. S., Mulkey, D. K. Tags: Cellular and Molecular Properties Of Neurons Source Type: research

Once-daily fluticasone furoate/vilanterol 100/25 mcg versus twice daily combination therapies in COPD ¿ mixed treatment comparisons of clinical efficacy
Conclusions: FF/VI 100/25 mcg was comparable with corresponding doses of FP/SAL and BUD/FORM on lung function and health status outcomes. Non-inferiority on moderate/severe exacerbation rate was not demonstrated to the same degree of confidence, though observed rates were similar. Model limitations include a weak treatment network for the exacerbation analysis and variability across the included studies. Our data support previous RCT findings suggesting that the efficacy of FF/VI 100/25 mcg on lung function and health status in COPD is comparable with twice-daily ICS/LABAs. (Source: Respiratory Research)
Source: Respiratory Research - February 15, 2015 Category: Respiratory Medicine Authors: Gillian StynesHenrik SvedsaterJaro WexSally LettisDavid LeatherEmanuela CastelnuovoMichelle DetryScott Berry Source Type: research

Tailored therapy for severe asthma.
Abstract Patients with severe asthma or COPD have often a suboptimal symptom control due to inadequate treatment. A better understanding of pathogenetic mechanisms, phenotypes, endotypes and the new technologies available in the fields of molecular biology and immunogenetics have made it possible to synthesize specific monoclonal antibodies virtually able to interact with any target antigen, or to open a way for new therapeutic target options. At the moment, the only biologic drug available in clinical practice is omalizumab. To overcome the limits of omalizumab, the research has focused on new monoclonal antibodie...
Source: Respiratory Care - February 14, 2015 Category: Respiratory Medicine Authors: Menzella F, Lusuardi M, Galeone C, Zucchi L Tags: Multidiscip Respir Med Source Type: research

BMJ Open Respiratory Research: 1 year on.
PMID: 25671133 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - February 14, 2015 Category: Respiratory Medicine Authors: Wise MP, Chapman SJ Tags: BMJ Open Respir Res Source Type: research

Insights into Intensive Care Unit Bed Expansion in the United States. National and Regional Analyses.
PMID: 25679100 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Pastores SM, Halpern NA Tags: Am J Respir Crit Care Med Source Type: research

Immune Modulation by α1-Antitrypsin. A Nice Concept, but Does It Influence Outcome?
PMID: 25679099 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Stockley RA Tags: Am J Respir Crit Care Med Source Type: research

Lung T Cells in HIV Infection. Driven to Exhaustion?
PMID: 25679103 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Cho JL, Medoff BD Tags: Am J Respir Crit Care Med Source Type: research

Preventing the NET Negative in Primary Graft Dysfunction.
PMID: 25679102 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Emtiazjoo A, Shilling RA Tags: Am J Respir Crit Care Med Source Type: research

A First Glimpse at the Early Origins of Idiopathic Pulmonary Fibrosis.
PMID: 25679101 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Eickelberg O, Hunninghake GM Tags: Am J Respir Crit Care Med Source Type: research

Relation between Recurrence of Tuberculosis and Transitional Changes in IFN-γ Release Assays.
PMID: 25679108 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Kaneko Y, Nakayama K, Kinoshita A, Kurita Y, Odashima K, Saito Z, Yoshii Y, Horikiri T, Seki A, Seki Y, Takeda H, Kuwano K Tags: Am J Respir Crit Care Med Source Type: research

Early Peripheral Perfusion-guided Fluid Therapy in Patients with Septic Shock.
PMID: 25679107 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: van Genderen ME, Engels N, van der Valk RJ, Lima A, Klijn E, Bakker J, van Bommel J Tags: Am J Respir Crit Care Med Source Type: research

Feasibility and Safety of Hydrotherapy in Critically Ill Ventilated Patients.
PMID: 25679106 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Felten-Barentsz KM, Haans AJ, Slutsky AS, Heunks LM, van der Hoeven JG Tags: Am J Respir Crit Care Med Source Type: research

Bilateral Pleural Effusion Associated with Miliary Sarcoidosis.
PMID: 25679105 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Enomoto Y, Yokomura K, Suda T Tags: Am J Respir Crit Care Med Source Type: research

Tuberculosis in Russia. Its History and Its Status Today.
Abstract The history of the Russian tuberculosis (TB) program, dating from the second part of the 19th century until today, is presented, and its achievements and failures are analyzed. The epidemiology of TB is described, and the effects of the TB program initiatives are described and analyzed. Multidrug-resistant TB and HIV coinfection represent severe threats to TB control effectiveness in Russia. New TB control strategies in the present-day epidemiological climate call for important shifts in TB facilities' networking, diagnosis, and treatment approaches. PMID: 25679104 [PubMed - as supplied by publisher] (...
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Yablonskii PK, Vizel AA, Galkin VB, Shulgina MV Tags: Am J Respir Crit Care Med Source Type: research

What Is Pertussis (Whooping Cough)?
Authors: PMID: 25679112 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply: Overestimation of Coprevalent and Underestimation of Incident Tuberculosis in Close Contacts.
PMID: 25679111 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 14, 2015 Category: Respiratory Medicine Authors: Sloot R, Schim van der Loeff MF, Kouw PM, Borgdorff MW Tags: Am J Respir Crit Care Med Source Type: research