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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

LGL1 modulates proliferation, apoptosis and migration of human fetal lung fibroblasts.
Abstract Rapid growth and formation of new gas exchange units (alveogenesis) are hallmarks of the perinatal lung. Bronchopulmonary dysplasia (BPD), common in very premature infants, is characterized by premature arrest of alveogenesis. Mesenchymal cells (fibroblasts) regulate both lung branching and alveogenesis through mesenchymal - epithelial interactions. Temporal or spatial deficiency of late gestation lung 1 (LGL1/CRISPLD2), expressed in and secreted by lung fibroblasts, can impair both lung branching and alveogenesis. Absence of Lgl1 is embryonic lethal. Lgl1 levels are dramatically reduced in oxygen toxicity...
Source: Am J Physiol Lung Ce... - December 5, 2014 Category: Respiratory Medicine Authors: Zhang H, Sweezey NB, Kaplan F Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

L-Thyroxine promotes a proliferative airway smooth muscle phenotype in the presence of TGF-β1.
Abstract Hypothyroidism may reduce, whereas hyperthyroidism may aggravate asthma symptoms. The mechanisms underlying this relationship are largely unknown. Since thyroid hormones have central roles in cell growth and differentiation, we hypothesized that airway remodeling, in particular increased airway smooth muscle (ASM) mass, may be involved. To address this hypothesis, we investigated the effects of triiodothyronine (T3) and L-thyroxine (T4) in the absence and presence of the profibrotic transforming growth factor (TGF)-β1 on human ASM cell phenotype switching. T3 (1-100 nM) and T4 (1-100 nM) did not affect ba...
Source: Am J Physiol Lung Ce... - December 5, 2014 Category: Respiratory Medicine Authors: Dekkers BG, Naeimi S, Bos IS, Menzen MH, Halayko AJ, Sadeghi Hashjin G, Meurs H Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Diabetes-Related Mortality in Adults with Cystic Fibrosis: Role of Genotype and Gender.
Conclusions Despite substantial improvement over time, mortality for CFRD patients >30 years remains higher than for CF patients without diabetes. PMID: 25479583 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 5, 2014 Category: Respiratory Medicine Authors: Lewis C, Blackman SM, Nelson A, Oberdorfer E, Wells D, Dunitz J, Thomas W, Moran A Tags: Am J Respir Crit Care Med Source Type: research

Who Cares About Preventing ARDS?
Abstract ARDS is a common, lethal, and morbid respiratory complication primarily seen in the setting of major trauma and infection. Despite advances in mechanical ventilation for ARDS, many interventions have not been successful in reducing mortality. Recent grant announcements and ongoing clinical trials indicate an interest in preventing ARDS. This Perspective challenges some of the basic assumptions of ARDS prevention and preventive care in the ICU. ARDS is an organ function surrogate outcome. Studies of surrogate outcomes in medicine have repeatedly failed to show an association with patient centered outcomes t...
Source: American Journal of Respiratory and Critical Care Medicine - December 5, 2014 Category: Respiratory Medicine Authors: Rubenfeld GD Tags: Am J Respir Crit Care Med Source Type: research

Timing of Low Tidal Volume Ventilation and ICU Mortality in ARDS: A Prospective Cohort Study.
Conclusions: Higher tidal volumes shortly after ARDS onset were associated with a greater risk of ICU mortality compared to subsequent tidal volumes. Timely recognition of ARDS and adherence to low tidal volume ventilation is important for reducing mortality. Clinicaltrials.gov NCT00300248. PMID: 25478681 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - December 5, 2014 Category: Respiratory Medicine Authors: Needham DM, Yang T, Dinglas VD, Mendez-Tellez PA, Shanholtz C, Sevransky JE, Brower RG, Pronovost PJ, Colantuoni E Tags: Am J Respir Crit Care Med Source Type: research

Does the 6-minute walk test predict nocturnal oxygen desaturation in patients with moderate to severe COPD?
Abstract Patients with chronic obstructive pulmonary disease (COPD) who have nocturnal oxygen desaturation (NOD) can be treated with nocturnal oxygen therapy (NOT) to avoid possible morbidity and mortality. Although there is no definite data recommending NOT alone, our aim is to evaluate the relationship between desaturation during the six-minute walk test (6MWT) and NOD in COPD. Fifty-five stable patients with COPD were enrolled in this study. The 6MWT and nocturnal oximetry were performed. Patients with comorbid diseases and respiratory failure were excluded. In total, 55 patients (49 males and 6 females, mean ag...
Source: Chronic Respiratory Disease - December 5, 2014 Category: Respiratory Medicine Authors: Iliaz S, Cagatay T, Bingol Z, Okumus G, Iliaz R, Kuran G, Kiyan E, Cagatay P Tags: Chron Respir Dis Source Type: research

Pathological changes in a patient with acute respiratory distress syndrome and H7N9 influenza virus infection
No abstract (Source: Critical Care)
Source: Critical Care - December 5, 2014 Category: Intensive Care Authors: Qiang GuoJian-an HuangDaguo ZhaoJun JinShenlang LiuDustin Fraidenburg Source Type: research

Respiratory syncytial virus - United States, july 2012-june 2014.
Abstract Respiratory syncytial virus (RSV) causes lower respiratory infection among infants and young children worldwide. Annually in the United States, RSV infection has been associated with an estimated 57,527 hospitalizations and 2.1 million outpatient visits among children aged <5 years. In temperate climate zones, RSV generally circulates during the fall, winter, and spring. However, the exact timing and duration of RSV seasons vary by region and from year-to-year. Knowing the start of the RSV season in any given locality is important to health care providers and public health officials who use RSV seasonal...
Source: MMWR Morb Mortal Wkl... - December 5, 2014 Category: Epidemiology Authors: Haynes AK, Prill MM, Iwane MK, Gerber SI Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Early Right Ventricular Fibrosis and Reduction in Biventricular Cardiac Reserve in the Dystrophin-Deficient mdx Heart.
Abstract Duchenne muscular dystrophy (DMD) is a progressive disease of striated muscle deterioration. Respiratory and cardiac muscle dysfunction are particularly clinically relevant because they result in the leading causes of death in DMD patients. Despite the clinical and physiological significance of these systems, little has been done to understand the cardio-respiratory interaction in DMD. We show here that prior to the onset of global cardiac dysfunction, dystrophin-deficient mdx mice have increased cardiac fibrosis with the right ventricle being particularly affected. Using a novel biventricular cardiac cath...
Source: American Journal of Physiology. Heart and Circulatory Physiology - December 5, 2014 Category: Physiology Authors: Meyers TA, Townsend D Tags: Am J Physiol Heart Circ Physiol Source Type: research

Cystic fibrosis (CF) care through the patients' eyes – A nationwide survey on experience and satisfaction with services using a disease-specific questionnaire
The patients' perspective is an important aspect of quality management. A newly developed disease-specific questionnaire was used to assess the patients' experiences with care provided in specialised cystic fibrosis (CF) care centres. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 5, 2014 Category: Respiratory Medicine Authors: Gratiana Steinkamp, Katja Stahl, Helmut Ellemunter, Eberhard Heuer, Silke van Koningsbruggen-Rietschel, Melanie Busche, Wilhelm Bremer, Carsten Schwarz, for the Patient Experience Working Group Source Type: research

[Measurement of CO diffusion capacity (II): Standardization and quality criteria.]
Abstract The diffusion capacity is the technique that measures the ability of the respiratory system for gas exchange, thus allowing a diagnosis of the malfunction of the alveolar-capillary unit. The most important parameter to assess is the CO diffusion capacity (DLCO). New methods are currently being used to measure the diffusion using nitric oxide (NO). There are other methods for measuring diffusion, although in this article the single breath technique is mainly referred to, as it is the most widely used and best standardized. Its complexity, its reference equations, differences in equipment, inter-patient vari...
Source: Anales de Pediatria - December 5, 2014 Category: Pediatrics Authors: Salcedo Posadas A, Villa Asensi JR, de Mir Messa I, Sardón Prado O, Larramona H Tags: An Pediatr (Barc) Source Type: research

A Bayesian spatio¿temporal approach for real¿time detection of disease outbreaks: a case study
Conclusions: The advantages of our methodology for addressing the complicated issues of real world surveillance data applications are three‐fold. We can easily incorporate additional covariate information and spatio‐temporal dynamics in the data. Second, we furnish a unified framework to provide uncertainties associated with each parameter. Third, we are able to handle multiplicity issues by using a Bayesian approach. The urgent need to quickly and effectively monitor the health of the public makes our methodology a potentially plausible and useful surveillance approach for health professionals. (Source: BMC Medical In...
Source: BMC Medical Informatics and Decision Making - December 5, 2014 Category: Information Technology Authors: Jian ZouAlan KarrGauri DattaJames LynchShaun Grannis Source Type: research

Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase.
Abstract Vulvovaginal candidiasis (VVC) is characterized by an infection of the vulva and vagina, mainly caused by Candida albicans, a commensal microorganism that inhabits the vaginal, digestive, and respiratory mucosae. Vulvovaginal candidiasis affects approximately 75% of women, and 5% develop the recurrent form (RVVC). The aim of the present study was to evaluate whether neutrophils microbicidal response is triggered when activated with RVVC isolates caused by C. albicans. Our results showed that RVVC isolates induced neutrophil migration but significantly decrease the microbicidal activity of neutrophils, comp...
Source: Cellular Immunology - December 5, 2014 Category: Allergy & Immunology Authors: Ratti BA, Godoy JS, de Souza Bonfim Mendonça P, Bidóia DL, Nakamura TU, Nakamura CV, Lopes Consolaro ME, Estivalet Svidzinski TI, de Oliveira Silva S Tags: Cell Immunol Source Type: research

Impact of bypass flow rate and catheter position in veno-venous extracorporeal membrane oxygenation on gas exchange in vivo
In conclusion, the best return cannula position was the SVC, and a high bypass flow rate was advantageous for effective oxygenation. Both the bypass flow rates and cannula position must be considered to achieve effective oxygenation. (Source: Journal of Artificial Organs)
Source: Journal of Artificial Organs - December 4, 2014 Category: Transplant Surgery Source Type: research

Alpha-1 antitrypsin deficiency-associated chronic obstructive pulmonary disease: a family perspective
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Breathlessness or Health Status in Chronic Obstructive Pulmonary Disease: The Impact of Different Definitions
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Prevalence, Risk Factors and Diagnostic Accuracy of COPD Among Smokers in Primary Care
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity
Journal of Medicinal ChemistryDOI: 10.1021/jm500902x (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - December 4, 2014 Category: Chemistry Authors: Daljit S. Matharu, Daniel P. Flaherty, Denise S. Simpson, Chad E. Schroeder, Donghoon Chung, Dan Yan, James W. Noah, Colleen B. Jonsson, E. Lucile White, Jeffrey Aubé, Richard K. Plemper, William E. Severson and Jennifer E. Golden Source Type: research

Evaluation of Minnesota and Illinois Hospital Respiratory Protection Programs and Health Care Worker Respirator Use
(Source: Journal of Occupational and Environmental Hygiene)
Source: Journal of Occupational and Environmental Hygiene - December 4, 2014 Category: Occupational Health Authors: Brosseau, Lisa M.Conroy, Lorraine M.Sietsema, MargaretCline, KariDurski, Kara Source Type: research

Epidemics of asbestos-related diseases – something old, something new
At the beginning of the 21st century, the world is still confronted with some well-recognized major occupational and environmental health hazards, such as the continuing use of asbestos fibers in various industrial products and processes. This in spite of authoritative statements from UN bodies (the World Health Organization, the International Labor Organization, and the UN Environment Program) and various NGO (1). These organizations have called on countries throughout the world to eliminate asbestos-related diseases. They point to the great potential for prevention through banning new applications of asbestos and availin...
Source: Scandinavian Journal of Work, Environment and Health - December 4, 2014 Category: Occupational Health Tags: Editorial Source Type: research

Endoscopic Lung Volume Reduction with Endobronchial Valves in Patients with Severe Emphysema and Established Pulmonary Hypertension
Conclusion: To our knowledge, this is the first prospective, single-center pilot study to evaluate the feasibility and efficacy of ELVR in patients with established PH. ELVR was feasible and resulted in an improvement of clinical and hemodynamic parameters in 5 out of 6 patients. These results have to be further confirmed in larger-scale controlled studies.Respiration (Source: Respiration)
Source: Respiration - December 4, 2014 Category: Respiratory Medicine Source Type: research

Considerations in deriving quantitative cancer criteria for inorganic arsenic exposure via inhalation.
Abstract The inhalation unit risk (IUR) that currently exists in the United States Environmental Protection Agency's (US EPA's) Integrated Risk Information System was developed in 1984 based on studies examining the relationship between respiratory cancer and arsenic exposure in copper smelters from two US locations: the copper smelter in Anaconda, Montana, and the American Smelting And Refining COmpany (ASARCO) smelter in Tacoma, Washington. Since US EPA last conducted its assessment, additional data have become available from epidemiology and mechanistic studies. In addition, the California Air Resources Board, T...
Source: Environment International - December 4, 2014 Category: Environmental Health Authors: Lewis AS, Beyer LA, Zu K Tags: Environ Int Source Type: research

The safety of ethambutol dihydrochloride dry powder formulations containing chitosan for the possibility of treating lung tuberculosis
Inhalation Toxicology, Volume 26, Issue 14, Page 908-917, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

A dynamic smoke generation and nose-only inhalation exposure system for rats: preliminary results from studies of selected transportation materials
Inhalation Toxicology, Volume 26, Issue 14, Page 897-907, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Respiratory symptoms, lung function decrement and chronic obstructive pulmonary disease in pre-menopausal Indian women exposed to biomass smoke
Inhalation Toxicology, Volume 26, Issue 14, Page 866-872, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Ultrafine carbon black attenuates the antihypertensive effect of captopril in spontaneously hypertensive rats
Inhalation Toxicology, Volume 26, Issue 14, Page 853-860, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Cigarette smoking is associated with dose-dependent adverse effects on paraoxonase activity and fibrinogen in young women
Inhalation Toxicology, Volume 26, Issue 14, Page 861-865, December 2014. (Source: Inhalation Toxicology)
Source: Inhalation Toxicology - December 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Infusing Interprofessional Education Into the Nursing Curriculum
Education for interprofessional collaboration should begin early in the nursing program with a gradual infusion of interprofessional competencies into the curriculum. The faculty developed an interprofessional education program for students in nursing, physical therapy, nutrition, and respiratory care, which focused on sharing knowledge about each discipline, developing respect and value for each other’s disciplines, and emphasizing techniques to improve communication and teamwork. (Source: Nurse Educator)
Source: Nurse Educator - December 4, 2014 Category: Nursing Tags: Feature Articles Source Type: research

Relationship between chronotropic incompetence and β-blockers based on changes in chronotropic response during cardiopulmonary exercise testing
Conclusions : An attenuated HR response may occur during the early stages of exercise. The HR response according to the presence or absence of β-blockers is clearly identifiable by comparing MCR-AT and MCR-Rc using the Wilkoff model. (Source: IJC Heart and Vasculature)
Source: IJC Heart and Vasculature - December 4, 2014 Category: Cardiology Source Type: research

Cervical lymph node metastasis as the first and only manifestation of prostatic adenocarcinoma
Publication date: Available online 4 December 2014 Source:Human Pathology: Case Reports Author(s): Tadashi Terada Prostatic carcinoma initially manifesting as only cervical lymph node swelling is a rare phenomenon. A 74-year-old man presented left cervical lymphadenopathy. An excisional biopsy was performed, and it was pathologically diagnosed as metastatic thyroid follicular carcinoma. However, imaging technique revealed no thyroid tumor or tumor in the body. The lymph node was re-examined 23months after the first diagnosis: it showed adenocarcinoma positive for PSA and PSAH. Biopsy of the prostate was performed immedia...
Source: Human Pathology: Case Reports - December 4, 2014 Category: Pathology Source Type: research

Sleep-related cortical arousals in adult subjects with negative polysomnography
Conclusions Age is the most important independent factor in predicting increasing AI in subjects with negative polysomnography. (Source: Sleep and Breathing)
Source: Sleep and Breathing - December 4, 2014 Category: Respiratory Medicine Source Type: research

Validation of the new COPD assessment test translated into Thai in patients with chronic obstructive pulmonary disease
Conclusions: The official Thai CAT questionnaire has an acceptable reliability and validity. It can be expected to serve as a short and simple tool for assessment of the health status of Thai COPD patients. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 4, 2014 Category: Respiratory Medicine Authors: Chaicharn PothiratSumalee KiatboonsriCharoen Chuchottaworn Source Type: research

A systematic review of the cost-effectiveness of targeted therapies for metastatic non-small cell lung cancer (NSCLC)
Conclusion: First-line maintenance treatment with erlotinib compared to Best Supportive Care (BSC) can be considered cost-effective. In comparison to docetaxel, erlotinib is likely to be cost-effective in subsequent treatment regimens as well. The insights for bevacizumab are miscellaneous. There are findings that gefitinib is cost-effective in first- and second-line treatment, however, based on only two studies. The role of pharmacogenomic testing needs to be evaluated. Therefore, future research should improve the available evidence and consider pharmacogenomic profiling as specified by the European Medicines Agency. Upc...
Source: BMC Pulmonary Medicine - December 4, 2014 Category: Respiratory Medicine Authors: Ansgar LangeAnne PrenzlerMartin FrankHeiko GolponTobias WelteJ-Matthias von der Schulenburg Source Type: research

Poly (ADP-Ribose) Polymerase1: An emerging target in right ventricle dysfunction associated with pulmonary hypertension
Publication date: Available online 3 December 2014 Source:Pulmonary Pharmacology &amp; Therapeutics Author(s): Gurpreet Kaur , Neetu Singh , Poorella Lingeshwar , Hefazat H. Siddiqui , Kashif Hanif Recently, inhibition of poly (ADP-ribose) polymerase1 (PARP1) was shown to be protective in experimental pulmonary hypertension (PH) and prevented right ventricular hypertrophy (RVH) associated with it. However, molecular mechanism behind cardioprotection by PARP1 inhibition in PH still needs detailed exploration. Therefore, effect of inhibition of PARP1 on the right ventricle (RV) dysfunction was studied in monocrotaline ...
Source: Pulmonary Pharmacology and Therapeutics - December 4, 2014 Category: Respiratory Medicine Source Type: research

PI3K and MEK1/2 molecular pathways are involved in the erythropoietin-mediated regulation of the central respiratory command
Publication date: 15 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 206 Author(s): Céline Caravagna , Jorge Soliz Erythropoietin stimulation modulates the central respiratory command in newborn mice. Specifically, the central respiratory depression induced by hypoxia is attenuated by acute (1h) or abolished by chronic erythropoietin stimulation. However, the underlying mechanisms remain unknown. As MEK and PI3K pathways are commonly involved in Epo-mediated effects of neuroprotection and erythropoiesis, we investigated here the implication of PI3K and MEK1/2 in the Epo-mediated regulation of t...
Source: Respiratory Physiology and Neurobiology - December 4, 2014 Category: Respiratory Medicine Source Type: research

Effects of tongue position and lung volume on voluntary maximal tongue protrusion force in humans
Publication date: Available online 4 December 2014 Source:Respiratory Physiology &amp; Neurobiology Author(s): Julian P. Saboisky , Billy L. Luu , Jane E. Butler , Simon C. Gandevia Maximal voluntary protrusion force of the human tongue has not been examined in positions beyond the incisors or at different lung volumes. Tongue force was recorded with the tongue tip at eight positions relative to the incisors (12 and 4mm protrusion, neutral and 4, 12, 16, 24 and 32mm retraction) at functional residual capacity (FRC), total lung capacity (TLC) and residual volume (RV) in 15 healthy subjects. Maximal force occurred betw...
Source: Respiratory Physiology and Neurobiology - December 4, 2014 Category: Respiratory Medicine Source Type: research

Identification of children at risk of influenza-related complications in primary and ambulatory care: a systematic review and meta-analysis
Publication date: Available online 4 December 2014 Source:The Lancet Respiratory Medicine Author(s): Peter J Gill , Helen F Ashdown , Kay Wang , Carl Heneghan , Nia W Roberts , Anthony Harnden , Susan Mallett Background Interventions to prevent influenza-related complications are recommended for individuals at the greatest risk of serious clinical deterioration. However, guidelines are based on consensus opinion rather than evidence, and do not specify risk factors in children. We aimed to provide an evidence-based definition of children who are most at risk of such complications. Methods In this systematic review, we s...
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research

Paediatric influenza vaccination: time to better protect high-risk groups?
Publication date: Available online 4 December 2014 Source:The Lancet Respiratory Medicine Author(s): Harish Nair , Marc-Alain Widdowson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 4, 2014 Category: Respiratory Medicine Source Type: research