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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection
Palivizumab was licensed in June 1998 by the Food and Drug Administration for the reduction of serious lower respiratory tract infection caused by respiratory syncytial virus (RSV) in children at increased risk of severe disease. Since that time, the American Academy of Pediatrics has updated its guidance for the use of palivizumab 4 times as additional data became available to provide a better understanding of infants and young children at greatest risk of hospitalization attributable to RSV infection. The updated recommendations in this policy statement reflect new information regarding the seasonality of RSV circulation...
Source: PEDIATRICS - August 1, 2014 Category: Pediatrics Authors: COMMITTEE ON INFECTIOUS DISEASES AND BRONCHIOLITIS GUIDELINES COMMITTEE Tags: From the American Academy of Pediatrics Source Type: research

Ambulatory ECMO as a Bridge to Lung Transplant in a Previously Well Pediatric Patient With ARDS
We describe the first case of a previously healthy pediatric patient with acute respiratory failure successfully supported with ambulatory ECMO as a bridge to lung transplant after an unsuccessful bridge to recovery. Although there are challenges associated with awake and ambulatory ECMO in children, this strategy represents an exciting breakthrough and a potential paradigm shift in ECMO management for pediatric acute respiratory failure. (Source: PEDIATRICS)
Source: PEDIATRICS - August 1, 2014 Category: Pediatrics Authors: Turner, D. A., Rehder, K. J., Bonadonna, D., Gray, A., Lin, S., Zaas, D., Cheifetz, I. M. Tags: Case Report Source Type: research

Successful Treatment of Plastic Bronchitis by Selective Lymphatic Embolization in a Fontan Patient
Plastic bronchitis is a rare and often fatal complication of single-ventricle surgical palliation after total cavopulmonary connection. Although lymphatic abnormalities have been postulated to play a role in the disease process, the etiology and pathophysiology of this complication remain incompletely understood. Here we report on the etiology of plastic bronchitis in a child with total cavopulmonary connection as demonstrated by magnetic resonance (MR) lymphangiography. We also report on a new treatment of this disease. The patient underwent noncontrast T2-weighted MR lymphatic mapping and dynamic contrast MR lymphangiogr...
Source: PEDIATRICS - August 1, 2014 Category: Pediatrics Authors: Dori, Y., Keller, M. S., Rychik, J., Itkin, M. Tags: Case Report Source Type: research

Updated Guidance for Palivizumab Prophylaxis Among Infants and Young Children at Increased Risk of Hospitalization for Respiratory Syncytial Virus Infection
Guidance from the American Academy of Pediatrics (AAP) for the use of palivizumab prophylaxis against respiratory syncytial virus (RSV) was first published in a policy statement in 1998. Guidance initially was based on the result from a single randomized, placebo-controlled clinical trial conducted in 1996–1997 describing an overall reduction in RSV hospitalization rate from 10.6% among placebo recipients to 4.8% among children who received prophylaxis. The results of a second randomized, placebo-controlled trial of children with hemodynamically significant heart disease were published in 2003 and revealed a reductio...
Source: PEDIATRICS - August 1, 2014 Category: Pediatrics Authors: COMMITTEE ON INFECTIOUS DISEASES and BRONCHIOLITIS GUIDELINES COMMITTEE Tags: From the American Academy of Pediatrics Source Type: research

Free‐breathing multislice native myocardial T1 mapping using the slice‐interleaved T1 (STONE) sequence
ConclusionThe STONE sequence allows accurate and precise quantification of native myocardial T1 times with the additional benefit of covering the entire ventricle. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - August 1, 2014 Category: Radiology Authors: Sebastian Weingärtner, Sébastien Roujol, Mehmet Akçakaya, Tamer A. Basha, Reza Nezafat Tags: Full Paper Source Type: research

Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments
Cigarette smoking (CS) can impact the immune system and induce pulmonary disorders such as chronic obstructive pulmonary disease (COPD), which is currently the fourth leading cause of chronic morbidity and mortality worldwide. Accordingly, the most significant risk factor associated with COPD is exposure to cigarette smoke. The purpose of the present study is to provide an updated overview of the literature regarding the effect of CS on the immune system and lungs, the mechanism of CS-induced COPD and oxidative stress, as well as the available and potential treatment options for CS-induced COPD. An extensive literature sea...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Zuo, L., He, F., Sergakis, G. G., Koozehchian, M. S., Stimpfl, J. N., Rong, Y., Diaz, P. T., Best, T. M. Tags: REVIEW Source Type: research

{gamma}-Herpes virus-68, but not Pseudomonas aeruginosa or influenza A (H1N1), exacerbates established murine lung fibrosis
Patients with idiopathic pulmonary fibrosis (IPF) often do worse following infection, but the cause of the decline is not fully understood. We previously demonstrated that infection with a murine gamma herpes virus (HV-68) could exacerbate established lung fibrosis following administration of fluorescein isothiocyanate (McMillan et al. Am J Respir Crit Care Med 177: 771–780, 2008). In the present study, we anesthetized mice and injected saline or bleomycin intratracheally on day 0. On day 14, mice were anesthetized again and infected with either a Gram-negative bacteria (Pseudomonas aeruginosa), or with H1N1 or HV-68...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Ashley, S. L., Jegal, Y., Moore, T. A., van Dyk, L. F., Laouar, Y., Moore, B. B. Tags: ARTICLES Source Type: research

Reduced platelet-derived growth factor receptor expression is a primary feature of human bronchopulmonary dysplasia
In conclusion, MSCs from infants who develop BPD hold stable alterations in PDGFR gene expression that favor hypoalveolarization. These data demonstrate that defective PDGFR signaling is a primary feature of human BPD. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Popova, A. P., Bentley, J. K., Cui, T. X., Richardson, M. N., Linn, M. J., Lei, J., Chen, Q., Goldsmith, A. M., Pryhuber, G. S., Hershenson, M. B. Tags: ARTICLES Source Type: research

Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation
In conclusion, we show that expression of Pim1 protects against CS-induced cell death in vitro and neutrophilic airway inflammation in vivo. Our data suggest that the underlying mechanism involves CS-induced release of S100A8 and KC. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: de Vries, M., Heijink, I. H., Gras, R., den Boef, L. E., Reinders-Luinge, M., Pouwels, S. D., Hylkema, M. N., van der Toorn, M., Brouwer, U., van Oosterhout, A. J. M., Nawijn, M. C. Tags: ARTICLES Source Type: research

Airway collagen and elastic fiber content correlates with lung function in equine heaves
The consequences on lung function and inflammation of alterations in the extracellular matrix affecting the peripheral airway wall in asthma are largely unknown. We hypothesized that remodeling of collagen and elastic fibers in the peripheral airway wall leads to airway obstruction and contributes to neutrophilic airway inflammation. Animals used were six heaves-affected horses and five controls. Large peripheral lung biopsies were obtained from horses with heaves in clinical remission (Baseline) and during disease exacerbation and from age-matched controls. The area of collagen and elastic fiber content in the lamina prop...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Setlakwe, E. L., Lemos, K. R., Lavoie-Lamoureux, A., Duguay, J.-D., Lavoie, J.-P. Tags: ARTICLES Source Type: research

Angiotensin II type 2 receptor ligand PD123319 attenuates hyperoxia-induced lung and heart injury at a low dose in newborn rats
Intervening in angiotensin (Ang)-II type 2 receptor (AT2) signaling may have therapeutic potential for bronchopulmonary dysplasia (BPD) by attenuating lung inflammation and preventing arterial hypertension (PAH)-induced right ventricular hypertrophy (RVH). We first investigated the role of AT2 inhibition with PD123319 (0.5 and 2 mg·kg–1·day–1) on the beneficial effect of AT2 agonist LP2–3 (5 μg/kg twice a day) on RVH in newborn rats with hyperoxia-induced BPD. Next we determined the cardiopulmonary effects of PD123319 (0.1 mg·kg–1·day–1) in two models: early trea...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Wagenaar, G. T. M., Sengers, R. M. A., Laghmani, E. H., Chen, X., Lindeboom, M. P. H. A., Roks, A. J. M., Folkerts, G., Walther, F. J. Tags: ARTICLES Source Type: research

Chloride channel blockade relaxes airway smooth muscle and potentiates relaxation by {beta}-agonists
Severe bronchospasm refractory to β-agonists continues to cause significant morbidity and mortality in asthmatic patients. We questioned whether chloride channels/transporters are novel targets for the relaxation of airway smooth muscle (ASM). We have screened a library of compounds, derivatives of anthranilic and indanyloxyacetic acid, that were originally developed to antagonize chloride channels in the kidney. We hypothesized that members of this library would be novel calcium-activated chloride channel blockers for the airway. The initial screen of this compound library identified 4 of 20 compounds that relaxed a ...
Source: AJP: Lung Cellular and Molecular Physiology - August 1, 2014 Category: Respiratory Medicine Authors: Danielsson, J., Yim, P., Rinderspacher, A., Fu, X. W., Zhang, Y., Landry, D. W., Emala, C. W. Tags: ARTICLES Source Type: research

The influence of asthma on face shape: a three-dimensional study.
Abstract SUMMARY Respiratory activity may have an influence on craniofacial development and interact with genetic and environmental factors. It has been suggested that certain medical conditions such as asthma have an influence on face shape. The aim of the study is to investigate whether facial shape is different in individuals diagnosed as having asthma compared with controls. Study design included observational longitudinal cohort study. Asthma was defined as reported wheezing diagnosed at age 7 years and 6 months. The cohort was followed to 15 years of age as part of the Avon Longitudinal Study of Parents and C...
Source: European Journal of Orthodontics - August 1, 2014 Category: Dentistry Authors: Al Ali A, Richmond S, Popat H, Toma AM, Playle R, Zhurov AI, Marshall D, Rosin PL, Henderson J Tags: Eur J Orthod Source Type: research

Food intake and energy expenditure are increased in high-fat-sensitive but not in high-carbohydrate-sensitive obesity-prone rats
This study showed that adiposity gain under HCD was 2.9-fold larger in carbohydrate-sensitive (CS) than in carbohydrate-resistant (CR) rats, confirming the concept of "carbohydrate-sensitive" rats. Energy expenditure (EE), respiratory quotient (RQ), caloric intake (CI), and locomotor activity measured during HFD identified no differences in EE and RQ between fat-resistant (FR) and fat-sensitive (FS) rats, and indicated that obesity developed in FS rats only as the result of a larger CI not fully compensated by a parallel increase in EE. A specific pattern of spontaneous activity, characterized by reduced activity burst int...
Source: AJP: Regulatory, Integrative and Comparative Physiology - August 1, 2014 Category: Physiology Authors: Azzout-Marniche, D., Chaumontet, C., Nadkarni, N. A., Piedcoq, J., Fromentin, G., Tome, D., Even, P. C. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Blood flow does not redistribute from respiratory to leg muscles during exercise breathing heliox or oxygen in COPD
In patients with chronic obstructive pulmonary disease (COPD), one of the proposed mechanisms for improving exercise tolerance, when work of breathing is experimentally reduced, is redistribution of blood flow from the respiratory to locomotor muscles. Accordingly, we investigated whether exercise capacity is improved on the basis of blood flow redistribution during exercise while subjects are breathing heliox (designed to primarily reduce the mechanical work of breathing) and during exercise with oxygen supplementation (designed to primarily enhance systemic oxygen delivery but also to reduce mechanical work of breathing)...
Source: Journal of Applied Physiology - August 1, 2014 Category: Physiology Authors: Louvaris, Z., Vogiatzis, I., Aliverti, A., Habazettl, H., Wagner, H., Wagner, P., Zakynthinos, S. Tags: ARTICLES Source Type: research

Pulmonary ventilation defects in older never-smokers
In conclusion, most never-smokers had normal spirometry and peripheral ventilation defects not reversed by DI/salbutamol; such ventilation defects were likely related to irreversible airway narrowing/collapse but not to dyspnea and decreased exercise capacity. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - August 1, 2014 Category: Physiology Authors: Sheikh, K., Paulin, G. A., Svenningsen, S., Kirby, M., Paterson, N. A. M., McCormack, D. G., Parraga, G. Tags: ARTICLES Source Type: research

The effects of an epithelial barrier protective cationic aerosol on allergen induced airway inflammation in asthma: a randomized, placebo‐controlled clinical trial
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - August 1, 2014 Category: Allergy & Immunology Authors: Parameswaran Nair, Shauna Denis, Laura Cancelliere, Katherine Radford, Ann Efthimiadis, Molly Rosano, John Hanrahan Tags: Opinion or Debate Source Type: research

Continuous positive airway pressure (CPAP) during the postoperative period for prevention of postoperative morbidity and mortality following major abdominal surgery.
CONCLUSIONS: Very low-quality evidence from this review suggests that CPAP initiated during the postoperative period might reduce postoperative atelectasis, pneumonia and reintubation, but its effects on mortality, hypoxia or invasive ventilation are uncertain. Evidence is not sufficiently strong to confirm the benefits or harms of CPAP during the postoperative period in those undergoing major abdominal surgery. Most of the included studies did not report on adverse effects attributed to CPAP.New, high-quality research is much needed to evaluate the use of CPAP in preventing mortality and morbidity following major abdomina...
Source: Cochrane Database of Systematic Reviews - August 1, 2014 Category: Journals (General) Authors: Ireland CJ, Chapman TM, Mathew SF, Herbison GP, Zacharias M Tags: Cochrane Database Syst Rev Source Type: research

NewsCAP: Despite guidelines, codeine is still prescribed for children with upper respiratory infection.
Authors: PMID: 25075688 [PubMed - in process] (Source: The American Journal of Nursing)
Source: The American Journal of Nursing - August 1, 2014 Category: Nursing Tags: Am J Nurs Source Type: research

Pro-inflammatory role of neutrophil extracellular traps in abdominal sepsis.
Abstract Excessive neutrophil activation is a major component in septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to bacterial invasions. The aim of the present study was to investigate the potential role of neutrophil extracellular traps (NETs) in septic lung injury. Male C57BL/6 mice were treated with rhDNAse (5 mg/kg) after cecal ligation and puncture (CLP). Extracellular DNA was stained by Sytox green and NET formation was quantified by confocal microscopy and cell-free DNA in plasma, peritoneal cavity and lung. Blood, peritoneal fluid and lung tissue were harvested for analys...
Source: Am J Physiol Lung Ce... - August 1, 2014 Category: Respiratory Medicine Authors: Luo L, Zhang S, Wang Y, Rahman M, Syk I, Zhang E, Thorlacius H Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS / immune complex induced acute lung injury.
In conclusion, we put forward a hypothesis that Btk targeted neutrophil specific therapy is a valid goal of research geared toward restoring homeostasis in lungs of patients with ALI/ARDS. PMID: 25085625 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - August 1, 2014 Category: Respiratory Medicine Authors: Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Catch me if you can: a wandering solitary fibrous tumor of the pleura.
PMID: 25084269 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Bhardwaj H, Lindley S, Bhardwaj B, Carlile PV, Huard DR Tags: Am J Respir Crit Care Med Source Type: research

Air crescent sign not caused by fungal or tuberculous infection.
PMID: 25084268 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Chen JY, Wei YF Tags: Am J Respir Crit Care Med Source Type: research

Reply: spirometry in the occupational setting.
PMID: 25084267 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Redlich CA, Tarlo SM, Hankinson JL, Townsend MC, Eschenbacher WL, Von Essen SG, Sigsgaard T, Weissman DN Tags: Am J Respir Crit Care Med Source Type: research

Spirometry in the occupational setting.
PMID: 25084266 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Ruppel GL, Mottram CD Tags: Am J Respir Crit Care Med Source Type: research

Vastus lateralis fiber shift is an independent predictor of mortality in chronic obstructive pulmonary disease.
PMID: 25084265 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Patel MS, Natanek SA, Stratakos G, Pascual S, Martínez-Llorens J, Disano L, Terzis G, Hopkinson NS, Gea J, Vogiatzis I, Maltais F, Polkey MI Tags: Am J Respir Crit Care Med Source Type: research

Does inspiratory muscle dysfunction predict readmission after intensive care unit discharge?
PMID: 25084264 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Adler D, Dupuis-Lozeron E, Richard JC, Janssens JP, Brochard L Tags: Am J Respir Crit Care Med Source Type: research

The antihypertensive effect of positive airway pressure on resistant hypertension of patients with obstructive sleep apnea: a randomized, double-blind, clinical trial.
PMID: 25084263 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Claudia de Oliveira A, Martinez D, Massierer D, Gus M, Cadaval Gonçalves S, Ghizzoni F, Maria Steinhorst A, Beltrami Moreira L, Costa Fuchs S, Fuchs FD Tags: Am J Respir Crit Care Med Source Type: research

Exhaled breath condensate in acute and chronic heart failure: new insights into the role of lung injury and barrier dysfunction.
PMID: 25084262 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Pappas LK, Giannopoulos G, Loukides S, Gavrielatos G, Athanasopoulou E, Alexanian IP, Farmakis D, Korovesi I, Letsas KP, Parissis JT, Deftereos S, Pyrgakis VN, Kotanidou A, Kremastinos DT, Filippatos GS Tags: Am J Respir Crit Care Med Source Type: research

Tadpoles in the lungs. Cement pulmonary embolism complicating vertebroplasty of spinal metastasis.
PMID: 25084261 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Chen CY, Cheng WE, Lin CH, Chen SC, Shih CM Tags: Am J Respir Crit Care Med Source Type: research

Pumping it up! Angiogenesis and muscle deconditioning in pulmonary hypertension.
PMID: 25084260 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: de Jesus Perez VA Tags: Am J Respir Crit Care Med Source Type: research

As galactomannan disappoints, our quest for a feasible diagnostic standard for invasive aspergillosis continues.
PMID: 25084259 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Vehreschild JJ Tags: Am J Respir Crit Care Med Source Type: research

The nasopharyngeal microbiota: an important window of opportunity.
PMID: 25084258 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Berrington JE, Cummings SP, Embleton ND Tags: Am J Respir Crit Care Med Source Type: research

Phenotypes That Matter: Pseudomonas aeruginosa and Progression of Cystic Fibrosis Lung Disease.
PMID: 25084257 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Sanders DB Tags: Am J Respir Crit Care Med Source Type: research

Understanding nocturnal asthma. The plot thickens.
PMID: 25084256 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 1, 2014 Category: Respiratory Medicine Authors: Mehra R Tags: Am J Respir Crit Care Med Source Type: research

August Highlights/Papers by Junior Investigators/NIH News.
Authors: PMID: 25084368 [PubMed - in process] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - August 1, 2014 Category: Respiratory Medicine Tags: Am J Respir Cell Mol Biol Source Type: research