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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Gastroesophageal Reflux in Idiopathic Pulmonary Fibrosis: More than a Gut Feeling?
Respiration 2016;91:1-2 (Source: Respiration)
Source: Respiration - January 26, 2016 Category: Respiratory Medicine Source Type: research

Airway epithelial repair in health and disease: Orchestrator or simply a player?
Abstract Epithelial cells represent the most important surface of contact in the body and form the first line of defence of the body to external environment. Consequently, epithelia have numerous roles in order to maintain a homeostatic defence barrier. Although the epithelium has been extensively studied over several decades, it remains the focus of new research, indicating a lack of understanding that continues to exist around these cells in specific disease settings. Importantly, evidence is emerging that airway epithelial cells in particular have varied complex functions rather than simple passive roles. One area of cu...
Source: Respirology - January 26, 2016 Category: Respiratory Medicine Authors: Thomas Iosifidis, Luke W. Garratt, Deirdre R. Coombe, Darryl A. Knight, Stephen M. Stick, Anthony Kicic Tags: Invited Review Source Type: research

Complex I function in mitochondrial supercomplexes
This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - January 26, 2016 Category: Biochemistry Source Type: research

Functional plasticity in the respiratory drive to thoracic motoneurons in the segment above a chronic lateral spinal cord lesion
A previous neurophysiological investigation demonstrated an increase in functional projections of expiratory bulbospinal neurons (EBSNs) in the segment above a chronic lateral thoracic spinal cord lesion that severed their axons. We have now investigated how this plasticity might be manifested in thoracic motoneurons by measuring their respiratory drive and the connections to them from individual EBSNs. In anesthetized cats, simultaneous recordings were made intracellularly from motoneurons in the segment above a left-side chronic (16 wk) lesion of the spinal cord in the rostral part of T8, T9, or T10 and extracellularly f...
Source: Journal of Neurophysiology - January 26, 2016 Category: Neurology Authors: Ford, T. W., Anissimova, N. P., Meehan, C. F., Kirkwood, P. A. Tags: Control Of Movement Source Type: research

Lethal Disorder of Mitochondrial Fission Caused by Mutations in
We describe two infants with hypotonia, absent respiratory effort, and giant mitochondria in neurons due to compound heterozygosity for 2 nonsense mutations of DNM1L. DNM1L has a critical role in regulating mitochondrial morphology and function. This observation confirms the central role of mitochondrial fission to normal human development. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - January 26, 2016 Category: Pediatrics Authors: Grace Yoon, Zeenat Malam, Tara Paton, Christian R. Marshall, Ella Hyatt, Zhenya Ivakine, Stephen W. Scherer, Kyong-Soon Lee, Cynthia Hawkins, Ronald D. Cohn, Finding of Rare Disease Genes (FORGE) in Canada Consortium Steering Committee Tags: Clinical and Laboratory Observations Source Type: research

Ebola Care and Lack of Consensus on Personal Protective Respiratory Equipment
The Ebola epidemic in West Africa presents a considerable occupational risk to the health personnel involved. The principal mode of virus transmission to health care personnel is through direct contact with the patient, although transmission by aerosols through the air may also occur. Many safety protocols have been suggested relating to personal protection and particularly respiratory protection. It is generally agreed that all health care workers should have easy access to personal protective equipment. However, the degree of respiratory safety escalates from a mask, to an adequate respirator, and finally to a whole body...
Source: Workplace Health and Safety - January 26, 2016 Category: Occupational Health Authors: Hanoa, R. O., Moen, B. E. Tags: Professional Practice Source Type: research

A holistic view of cancer bioenergetics: mitochondrial function and respiration play fundamental roles in the development and progression of diverse tumors
Since Otto Warburg made the first observation that tumor cells exhibit altered metabolism and bioenergetics in the 1920s, many scientists have tried to further the understanding of tumor bioenergetics. Particularly, in the past decade, the application of the state-of the-art metabolomics and genomics technologies has revealed the remarkable plasticity of tumor metabolism and bioenergetics. Firstly, a wide array of tumor cells have been shown to be able to use not only glucose, but also glutamine for generating cellular energy, reducing power, and metabolic building blocks for biosynthesis. Secondly, many types of cancer ce...
Source: Clinical and Translational Medicine - January 26, 2016 Category: Internal Medicine Authors: Md AlamSneha LalKeely FitzGeraldLi Zhang Source Type: research

Low-Dose Ketamine in Chronic Critical Illness
We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness. Doses of ketamine infusion ranged from 0.5 to 4 μg/kg/min. A low-dose ketamine infusion was used to reduce agitation in a patient requiring high doses of sedatives and analgesics. In a second patient, ketamine improved depression and anxiety symptoms. In a third patient, ketamine may have facilitated liberation from mechanical ventilation. In a fourth patient, ketamine was used for palliation to avoid lethargy. Ketamine may be considered to help dec...
Source: Journal of Intensive Care Medicine - January 26, 2016 Category: Intensive Care Authors: Moitra, V. K., Patel, M. K., Darrah, D., Moitra, A., Wunsch, H. Tags: Case Report Source Type: research

IJERPH, Vol. 13, Pages 161: Factors Associated with Complete Home Smoking Ban among Chinese Parents of Young Children
Conclusions: A home smoking ban is not widely adopted by families of hospitalized children in Guangxi Province, China. To protect the health of children, there is a need to develop and test interventions to promote home smoking bans. Factors identified as predictors of home smoking ban should be considered in the design of interventions. (Source: International Journal of Environmental Research and Public Health)
Source: International Journal of Environmental Research and Public Health - January 26, 2016 Category: Environmental Health Authors: Kaiyong HuangHailian ChenJing LiaoGuangmin NongLi YangJonathan WinickoffZhiyong ZhangAbu Abdullah Tags: Article Source Type: research

A randomized controlled study comparing intrathecal hyperbaric bupivacaine-fentanyl mixture and isobaric bupivacaine-fentanyl mixture in common urological procedures
Conclusion: Isobaric bupivacaine fentanyl mixture was found to provide adequate anaesthesia with minimal incidence of haemodynamic instability. (Source: Indian Journal of Anaesthesia)
Source: Indian Journal of Anaesthesia - January 26, 2016 Category: Anesthesiology Authors: Madhusudan UpadyaS NeetaJesni Joseph ManisseryNigel KuriakoseRakesh Raushan Singh Source Type: research

ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children
nks & S Sadhasivam (Source: The Pharmacogenomics Journal)
Source: The Pharmacogenomics Journal - January 26, 2016 Category: Drugs & Pharmacology Authors: V ChidambaranR VenkatasubramanianX ZhangL J MartinJ NiuT MizunoT FukudaJ MellerA A VinksS Sadhasivam Source Type: research

Review of the home care programmes for respiratory syncytial virus (RSV) prophylaxis in Ireland and The Netherlands
Abstract Severe infection of infants with respiratory syncytial virus (RSV) is a leading cause of morbidity in the developed world and mortality in the developing world. Prophylaxis using palivizumab in infants at risk for severe RSV disease reduces the rate of hospitalisation in this population of children. To ensure complete prophylaxis, infants must receive monthly doses over the winter season. To improve parental convenience, the Synacare® programme was implemented in Ireland and the Netherlands. Synacare® is now a longstanding programme in which palivizumab is administered in the home setting by skilled...
Source: Drugs and Therapy Perspectives - January 26, 2016 Category: Drugs & Pharmacology Source Type: research

A randomized controlled trial on the benefits and respiratory adverse effects of morphine for refractory dyspnea in patients with COPD: Protocol of the MORDYC study
This study primarily evaluates the impact of oral sustained release morphine (morphine SR) on health-related quality of life and respiratory adverse effects in patients with COPD. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - January 26, 2016 Category: Radiology Authors: C.A. Verberkt, M.H.J. van den Beuken-van Everdingen, F.M.E. Franssen, C.D. Dirksen, J.M.G.A. Schols, E.F.M. Wouters, D.J.A. Janssen Source Type: research

Biopsy‐proven pulmonary capillaritis: A retrospective study of aetiologies including an in‐depth look at isolated pulmonary capillaritis
ConclusionPulmonary capillaritis is most commonly secondary to systemic autoimmune disorders, predominantly ANCA‐associated vasculitis. IPC is a rare form of pulmonary capillaritis with very few cases described in the literature, the availability of effective treatment makes this rare disease important to recognize. (Source: Respirology)
Source: Respirology - January 26, 2016 Category: Respiratory Medicine Authors: Gwen Thompson, Mary Klecka, Anja C. Roden, Ulrich Specks, Rodrigo Cartin‐Ceba Tags: Original Article Source Type: research

BMPR2 gene therapy for PAH acts via Smad and non‐Smad signalling
ConclusionThese results indicate that the therapeutic effect of BMPR2 gene delivery on PAH is associated with a switch between TGF‐β‐Smad2/3 signalling to BMPR2‐Smad1/5/8 signalling. This supports the further development of this treatment approach. (Source: Respirology)
Source: Respirology - January 26, 2016 Category: Respiratory Medicine Authors: Rebecca L. Harper, Ann M. Reynolds, Claudine S. Bonder, Paul N. Reynolds Tags: Original Article Source Type: research

Microbiological yield from induced sputum compared to oropharyngeal swab in young children with cystic fibrosis
Standard respiratory sampling in young children with cystic fibrosis (CF) is by oropharyngeal swab (OPS) as they cannot spontaneously expectorate. Sputum induction (IS) has been poorly investigated in this population. We aimed to compare the bacteriological yield of OPS vs. IS in young children with CF. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - January 26, 2016 Category: Respiratory Medicine Authors: Marco Zampoli, Komala Pillay, Henri Carrara, Heather J. Zar, Brenda Morrow Tags: Original Article Source Type: research

Prevalence of Mycoplasma gallisepticum and Mycoplasma synoviae in commercial poultry, racing pigeons and wild birds in Belgium.
Abstract Mycoplasma gallisepticum is the most important pathogenic avian Mycoplasma species and causes chronic respiratory disease in poultry. In addition, the prevalence of Mycoplasma synoviae is of increasing concern in several EU member states. We investigated the prevalence of M. gallisepticum in commercial poultry (5220 layers, 1224 broilers and 1020 meat turkeys), 56 racing pigeons and 890 wild birds (Order Anseriformes, Galliformes, Pelecaniformes, Accipitriformes, Gruiformes, Charadriiformes, Columbiformes, Strigiformes, Falconiformes and Passeriformes). Broilers and wild birds were also evaluated for M. sy...
Source: Avian Pathology - January 26, 2016 Category: Pathology Authors: Michiels T, Welby S, Vanrobaeys M, Quinet C, Rouffaer L, Lens L, Martel A, Butaye P Tags: Avian Pathol Source Type: research

Apibacter mensalis sp. nov.: a rare member of the bumble bee gut microbiota.
Abstract Isolates LMG 28357T (= R-53146) and LMG 28623 were obtained from gut samples of Bombus lapidarius bumble bees caught in Ghent, Belgium. They had identical 16S rRNA gene sequences which were 95.7% identical to that of Apibacter adventoris wkB301T, a member of the family Flavobacteriaceae. Both isolates had highly similar MALDI-TOF MS and RAPD profiles. A draft genome sequence was obtained for strain LMG 28357T (Gold ID Gp0108260); its DNA G+C content was 30.4% which is within the range reported for members of the family Flavobacteriaceae (27 to 56 mol%) and which is similar to that of the type strain of A. ...
Source: International Journal of Systematic and Evolutionary Microbiology - January 26, 2016 Category: Microbiology Authors: Praet J, Aerts M, De Brandt E, Meeus I, Smagghe G, Vandamme P Tags: Int J Syst Evol Microbiol Source Type: research

The feasibility of the auto tuning respiratory compensation system with ultrasonic image tracking technique.
In this study, the developed ultrasound image analysis techniques combined into the auto tumor localization system has the following four advantages: (1) It is a non-invasive way (ultrasonic images) to monitor the entire compensating process of the active respiration instead of using a C-arm (invasive) to observe the organs motion. (2) During radiation therapy, the whole treatment process can be continuous, which can save the overall treatment time. (3) It is an independent system, which can be mounted onto any treatment couch. (4) Users can operate this system easily without the need of prior complicated training process....
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Automatic detection method of hepatocellular carcinomas using the non-rigid registration method of multi-phase liver CT images.
CONCLUSION: We conclude that our method is useful for detecting hepatocellular carcinomas. PMID: 26410463 [PubMed - in process] (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Individual thorax geometry reduces position and size differences in reconstructed images of electrical impedance tomography.
CONCLUSION: The reconstructed images using the GREIT method with individual thorax geometry were more realistic. Improvement of EIT image quality may foster the acceptance of EIT in routine clinical use. PMID: 25408396 [PubMed - indexed for MEDLINE] (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Theoretical modeling of mobile target broadening in helical and axial computed tomographic imaging.
CONCLUSION: The measured and model variations of apparent lengths of mobile targets are considerable and may affect the accuracy of tumor volumes obtained from HCT and ACT. This mathematical model provides a method to quantitatively assess the length variations of mobile targets and their dependence on motion parameters of the phantom and imaging system which may have potential applications in the fields of diagnostic imaging and radiotherapy. PMID: 24865210 [PubMed - indexed for MEDLINE] (Source: Journal of X-Ray Science and Technology)
Source: Journal of X-Ray Science and Technology - January 25, 2016 Category: Radiology Tags: J Xray Sci Technol Source Type: research

Relationships Between Tobacco Abuse and Self-Assessment of Health.
Authors: Gawlikowska-Sroka A, Dzięciołowska-Baran E, Szczurowski J Abstract Smoking cigarettes negatively influences the functioning of the body. Among other effects, it has an important impact on the respiratory system, circulation, and behavior. It leads to morphological and physiological changes in organs and tissues, so it can change mood. The aim of this study was to assess the relationships between tobacco abuse and self-assessment of health. The survey was conducted among Polish (243) and foreign (80) medical students at the Pomeranian Medical University in Szczecin, Poland. The study was based on a survey...
Source: Advances in Experimental Medicine and Biology - January 25, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0-59 Months.
Authors: Nitsch-Osuch A, Kuchar E, Topczewska-Cabanek A, Wardyn K, Życińska K, Brydak L Abstract Clinical data available on coinfections are contradictory concerning both the number of viruses involved and the severity of the condition. A total of 114 patients aged 0-59 months with symptoms of respiratory tract infection were enrolled into the study. Nasal and pharyngeal swabs were tested using the PCR method for the following 12 viruses: influenza A, influenza B, respiratory syncytial virus A (RSV A), respiratory syncytial virus B (RSV B), adenovirus, metapneumovirus, coronavirus 229E/NL63 (hCoV229), coronaviru...
Source: Advances in Experimental Medicine and Biology - January 25, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Growth, Nutritional Status, and Pulmonary Function in Children with Chronic Recurrent Bronchitis.
Authors: Umławska W, Lipowicz A Abstract Bronchitis is a common health problem in children. Frequent bronchitis in infancy increases the risk of developing chronic respiratory diseases. The aim of the study was to assess the level of growth and the nutritional status in children and youths with special regard to the level of body fatness assessed by measuring skin-fold thickness. Relationships between somatic development, pulmonary function and the course of the disease were also explored. The study was carried out using anthropometric and spirometric measurements and also information on the severity and course of...
Source: Advances in Experimental Medicine and Biology - January 25, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Antibiotic Prescription Practices Among Children with Influenza.
Authors: Nitsch-Osuch A, Gyrczuk E, Wardyn A, Życinska K, Brydak L Abstract The important factor in the development of resistance to antibiotics is their overuse, especially for viral respiratory infections. The aim of the study was to find out the frequency of the antibiotic therapy administrated to children with influenza. A total of 114 children younger than 59 months seeking care for the acute respiratory tract infection was enrolled into the study. The patients had influenza-like symptoms: fever > 38 °C, cough, and sore throat of less than 4 days duration. Nasal and pharyngeal swabs were tested for i...
Source: Advances in Experimental Medicine and Biology - January 25, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Current Strategies in Anesthesia and Analgesia for Total Knee Arthroplasty.
Authors: Moucha CS, Weiser MC, Levin EJ Abstract Total knee arthroplasty is associated with substantial postoperative pain that may impair mobility, reduce the ability to participate in rehabilitation, lead to chronic pain, and reduce patient satisfaction. Traditional general anesthesia with postoperative epidural and patient-controlled opioid analgesia is associated with an undesirable adverse-effect profile, including postoperative nausea and vomiting, hypotension, urinary retention, respiratory depression, delirium, and an increased infection rate. Multimodal anesthesia-incorporating elements of preemptive analg...
Source: The Journal of the American Academy of Orthopaedic Surgeons - January 25, 2016 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

There is no cephalocaudal gradient of computed tomography densities or lung behavior in supine patients with acute respiratory distress syndrome
ConclusionsWe could not detect cephalocaudal gradients in lung densities or in alveolar collapse. Likely, external pressures applied on the lung by the chest wall, organs, and effusions are transmitted throughout the lung in a hydrostatic pattern with homogeneous consequences at each isogravitational layer. A single cross‐sectional image of the lung could fully represent the heterogeneous mechanical properties of dependent and non‐dependent lung regions. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - January 25, 2016 Category: Anesthesiology Authors: S. A. El‐Dash, J. B. Borges, E. L. V. Costa, M. R. Tucci, O. T. Ranzani, M. P. Caramez, C. R. R. Carvalho, M. B. P. Amato Tags: Original Article Source Type: research

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations.
CONCLUSIONS: The lack of evidence pertinent to managing rhinosinusitis during pregnancy warrants future trials. Expert recommendations constitute the current best available evidence. PMID: 26800862 [PubMed - as supplied by publisher] (Source: Rhinology)
Source: Rhinology - January 25, 2016 Category: ENT & OMF Tags: Rhinology Source Type: research

Blood eosinophils: the Holy Grail for asthma phenotyping?
Asthma has been generally defined as a chronic inflammatory disorder of the airways with bronchial hyperresponsiveness and reversible variable airflow obstruction, affecting 6% to 8% of the US population.1 For many years, the mainstay of therapy has been inhaled corticosteroids (ICSs) and systemic corticosteroids. However, not all individuals with asthma respond to these standard treatments. Approximately 5% to 10% of individuals with asthma can be classified as having severe asthma based on the international European Respiratory Society/American Thoracic Society guidelines definition that requires treatment with a high-do...
Source: Annals of Allergy, Asthma and Immunology - January 25, 2016 Category: Allergy & Immunology Authors: Merritt L. Fajt Tags: Guest Editorial Source Type: research

A Colorado allergist's experience with marijuana legalization
Although I appreciated the fine review by Ocampo and Rans entitled Cannabis Sativa: The Unconventional “Weed” Allergen,1 I thought it would be worthwhile to describe the few adverse reactions seen in our patient population. The relative paucity of these presentations since legalization of marijuana in Colorado suggests that cannabis sativa is a mild allergen, with significant exposure required to elicit respiratory and dermatologic allergic reactions. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 25, 2016 Category: Allergy & Immunology Authors: William S. Silvers Tags: Correspondence Source Type: research

Perception of verticality and cardiovascular responses during short-radius centrifugation.
CONCLUSIONS: These results suggest that one group of subject was relying principally on the otolith organs for the perception of verticality, whereas the other group was also relying on extravestibular somatosensory receptors. The crewmember's perception of verticality might be a factor to take into account for the prescription for artificial gravity during spaceflight. PMID: 24594494 [PubMed - indexed for MEDLINE] (Source: Journal of Vestibular Research: Equilibrium and Orientation)
Source: Journal of Vestibular Research: Equilibrium and Orientation - January 25, 2016 Category: Neuroscience Tags: J Vestib Res Source Type: research

The effect of passive exposure to tobacco smoke on perioperative respiratory complications and the duration of recovery
Conclusion Passive tobacco smoke exposed general anesthesia receiving patients also regarding to the degree of exposure having high rates of perioperative respiratory complications and prolongation of PACU stays when compared with unexposed patients. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - January 25, 2016 Category: Anesthesiology Source Type: research

Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high‐fat diet‐fed mice
ConclusionsWild ginseng CMCs protect against HFD‐induced liver injury, which prevents lipid accumulation and mitochondrial oxidative stress, and enhances mitochondrial biogenesis. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - January 25, 2016 Category: Drugs & Pharmacology Authors: Sang‐Bin Lee, Hong‐Ik Cho, Young‐Woo Jin, Eun‐Kyong Lee, Jeung Youb Ahn, Sun‐Mee Lee Tags: Research Paper Source Type: research

Medicinal plants in Brazil: Pharmacological studies, drug discovery, challenges and perspectives
In conclusion, in spite of the abundant Brazilian biodiversity and the thousands of academic publications on plants in international peer-reviewed scientific journals, few patents and medicines have been derived from such studies. Undoubtedly, great efforts must be made to improve the development of plant-derived medicine market in Brazil, especially by involving the partnership between academia and pharmaceutical companies. Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - January 25, 2016 Category: Drugs & Pharmacology Source Type: research

The Endogenous Cannabinoid Anandamide Increases Human Airway Epithelial Cell Permeability through an Arachidonic Acid Metabolite
Publication date: Available online 22 January 2016 Source:Pharmacological Research Author(s): V.C.M. Shang, S.E. O’Sullivan, D.A. Kendall, R.E. Roberts Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the loss of barrier function and an elevated sensitivity to environmental insults. An increased release of the endogenous cannabinoid, anandamide in response to inhalation of allergen in asthmatic patients has been reported. The aim of this study was, therefore, to determine the effects of endocannabinoids on bronchial epithelial cell permeability and to investigate the mec...
Source: Pharmacological Research - January 25, 2016 Category: Drugs & Pharmacology Source Type: research

The Dynamic Relationship Between Clinical Symptomatology and Viral Shedding in Naturally Acquired Seasonal and Pandemic Influenza Virus Infections
Conclusions. Our results suggest that while clinical illness profiles may serve as a proxy for clinical infectiousness in influenza A virus infections, patients may potentially be infectious even before symptom onset or after clinical improvement in influenza B virus infections. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 25, 2016 Category: Infectious Diseases Authors: Ip, D. K. M., Lau, L. L. H., Chan, K.-H., Fang, V. J., Leung, G. M., Peiris, M. J. S., Cowling, B. J. Tags: ARTICLES AND COMMENTARIES Source Type: research

Illness Severity and Work Productivity Loss Among Working Adults With Medically Attended Acute Respiratory Illnesses: US Influenza Vaccine Effectiveness Network 2012-2013
Conclusions. Influenza illnesses were more severe and resulted in more missed work hours and productivity loss than illnesses not confirmed as influenza. Modest reductions in illness severity for vaccinated cases were observed. These findings highlight the burden of influenza illnesses and illustrate the importance of laboratory confirmation of influenza outcomes in evaluations of vaccine effectiveness. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 25, 2016 Category: Infectious Diseases Authors: Petrie, J. G., Cheng, C., Malosh, R. E., VanWormer, J. J., Flannery, B., Zimmerman, R. K., Gaglani, M., Jackson, M. L., King, J. P., Nowalk, M. P., Benoit, J., Robertson, A., Thaker, S. N., Monto, A. S., Ohmit, S. E. Tags: ARTICLES AND COMMENTARIES Source Type: research

Viral Shedding and Antibody Response in 37 Patients With Middle East Respiratory Syndrome Coronavirus Infection
Conclusions. The timing and intensity of respiratory viral shedding in patients with MERS closely matches that of those with severe acute respiratory syndrome. Blood viral RNA does not seem to be infectious. Extrapulmonary loci of virus replication seem possible. Neutralizing antibodies do not suffice to clear the infection. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 25, 2016 Category: Infectious Diseases Authors: Corman, V. M., Albarrak, A. M., Omrani, A. S., Albarrak, M. M., Farah, M. E., Almasri, M., Muth, D., Sieberg, A., Meyer, B., Assiri, A. M., Binger, T., Steinhagen, K., Lattwein, E., Al-Tawfiq, J., Müller, M. A., Drosten, C., Memish, Z. A. Tags: ARTICLES AND COMMENTARIES Source Type: research

The Vaccine Candidate Substrate Binding Protein SBP2 Plays a Key Role in Arginine Uptake, Which Is Required for Growth of Moraxella catarrhalis [Bacterial Infections]
In this study, we showed that SBP1, -2, and -3 individually bind different basic amino acids with exquisite specificity. We engineered mutants that each expressed a single SBP from this gene cluster and showed in growth experiments that SBP1, -2, and -3 serve a nutritional function through acquisition of amino acids for the bacterium. SBP2 mediates uptake of arginine, a strict growth requirement of M. catarrhalis. Adherence and invasion assays demonstrated that SBP1 and SBP3 play a role in invasion of human respiratory epithelial cells, consistent with a nutritional role in intracellular survival in the human respiratory t...
Source: Infection and Immunity - January 25, 2016 Category: Infectious Diseases Authors: Otsuka, T., Kirkham, C., Brauer, A., Koszelak-Rosenblum, M., Malkowski, M. G., Murphy, T. F. Tags: Bacterial Infections Source Type: research

Expression of oestrogen receptor α in the endometrium of porcine reproductive and respiratory syndrome virus-infected gilts
Abstract Porcine reproductive and respiratory syndrome (PRRS) virus infection often lead to infertility in gilts and sows. Nevertheless, the impact of PRRS virus on the endometrial function has not been fully elucidated. The present study aimed to determine the effect of PRRS virus infection on the expression of oestrogen receptor (ER) α in the endometrium of gilts. Uterine tissues from 54 gilts were classified into two groups according to PRRS virus detection using immunohistochemistry (26 positive and 28 negative samples). The reproductive status was classified as prepubertal, luteal and follicular phases. The ...
Source: Comparative Clinical Pathology - January 25, 2016 Category: Pathology Source Type: research

Neutrophil extracellular traps are associated with inflammation in chronic airway disease
ConclusionNETs are present in the airways of subjects with asthma and COPD. Accumulation of excessive NETs was associated with activation of innate immune responses contributing to disease pathogenesis in chronic airway disease. (Source: Respirology)
Source: Respirology - January 25, 2016 Category: Respiratory Medicine Authors: Thomas K. Wright, Peter G. Gibson, Jodie L. Simpson, Vanessa M. McDonald, Lisa G. Wood, Katherine J. Baines Tags: Original Article Source Type: research

Additive anti-inflammatory effects of corticosteroids and phosphodiesterase-4 inhibitors in COPD CD8 cells
Conclusion: The combination of corticosteroids and PDE4 inhibitors results in an additive anti-inflammatory effect in COPD CD8 cells. This enhanced anti-inflammatory effect could translate to important clinical benefits for patients with COPD. (Source: Respiratory Research)
Source: Respiratory Research - January 25, 2016 Category: Respiratory Medicine Authors: Seamus GrundyJonathan PlumbManminder KaurDavid RayDave Singh Source Type: research

A Case of IgG4‐related Lung Disease Complicated by Asymptomatic Chronic Epstein‐Barr Virus Infection
This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 25, 2016 Category: Respiratory Medicine Authors: Yasuaki Kotetsu, Satoshi Ikegame, Keiko Takebe‐Akazawa, Takaomi Koga, Kan Okabayashi, Shohei Takata Tags: Original Article Source Type: research

Limited Value of Transbronchial Lung Biopsy for Diagnosing Mycobacterium avium Complex Lung Disease
Conclusion: TBLB for pathological and bacterial investigations would provide only a limited value for MAC diagnosis. Moreover, the presence of intrabronchial secretion may be an important manifestation of ongoing airway damage, which would require early treatment. This article is protected by copyright. All rights reserved. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - January 25, 2016 Category: Respiratory Medicine Authors: Akimasa Sekine, Takefumi Saito, Hiroaki Satoh, Yukio Morishita, Yoshiya Tsunoda, Toru Tanaka, Yohei Yatagai, Shih‐Yuen Lin, Kunihiko Miyazaki, Yukiko Miura, Kenji Hayashihara Tags: Original Article Source Type: research