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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Sclerosing Hemangioma of the Lung Mimicking Pulmonary Metastasis
We report a case of SH initially misdiagnosed as malignant due to the strong FDG-PET uptake. (Source: Lung)
Source: Lung - March 12, 2015 Category: Respiratory Medicine Source Type: research

The Ratio of Free to Bound Desmosine and Isodesmosine May Reflect Emphysematous Changes in COPD
Conclusions The free/bound DID ratio may be a useful measure of emphysematous changes in the lung and might also serve as a screening procedure for healthy smokers and other individuals at risk for developing COPD. (Source: Lung)
Source: Lung - March 12, 2015 Category: Respiratory Medicine Source Type: research

Changes in Pulmonary Function and Controlled Ventilation-High Resolution CT of Chest After Antibiotic Therapy in Infants and Young Children with Cystic Fibrosis
Conclusion IPFT and CV-HRCT can be used as objective measures of improvement in lung disease for infants with CF treated with antibiotics. (Source: Lung)
Source: Lung - March 12, 2015 Category: Respiratory Medicine Source Type: research

Alterations in blood leukocytes of G551D-bearing cystic fibrosis patients undergoing treatment with ivacaftor
Ivacaftor improves clinical outcome by potentiation of mutant G551D CFTR. Due to the presence of CFTR in monocytes and polymorphonuclear neutrophils (PMNs), we hypothesized that ivacaftor may impact leukocyte activation. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - March 12, 2015 Category: Respiratory Medicine Authors: Preston E. Bratcher, Steven M. Rowe, Ginger Reeves, Tambra Roberts, Tomasz Szul, William T. Harris, Rabindra Tirouvanziam, Amit Gaggar Tags: Original Article Source Type: research

Prognostic factors affecting survival in non small cell lung carcinoma patients with malignant pleural effusions
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Umut Kasapoglu, Sibel Arınç, Sinem Gungor, Ilim Irmak, Pinar Guney, Ferda Aksoy, Dilek Bandak, Armagan Hazar Tags: Original Article Source Type: research

Correlation between the Wells Score and the Quanadli Index in Patients with Pulmonary Embolism
ConclusionModified Wells criteria have high sensitivity, but low specificity in PE diagnostics. The Wells score does not correlate well with the Quanadli index. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Dušanka Obradović, Biljana Joveš, Slobodanka Pena Karan, Srdjan Stefanović, Igor Ivanov, Marija Vukoja Tags: Original Article Source Type: research

DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis
Abstract IntroductionPseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients is associated with worse long‐term pulmonary disease and shorter survival, and chronic Pa infection (CPA) is associated with reduced lung function, faster rate of lung decline, increased rates of exacerbations and shorter survival. By using exome sequencing and extreme phenotype design, it was recently shown that isoforms of dynactin 4 (DCTN4) may influence Pa infection in CF, leading to worse respiratory disease. ObjectivesThe purpose of this study was to investigate the role of DCTN4 missense variants on Pa infection incidence, ...
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Marion Viel, Dominique Hubert, Pierre‐Regis Burgel, Emmanuelle Génin, Isabelle Honoré, Brigitte Martinez, Natacha Gaitch, Jeanne Chapron, Reem Kanaan, Daniel Dusser, Emmanuelle Girodon, Thierry Bienvenu Tags: Original Article Source Type: research

Successful embolization in childhood hemoptysis due to abnormal systemic arterial bleeding of the lung and review of the literature
ConclusionMassive hemoptysis due to abnormal systemic bleeding of the lung in the absence of parenchymal disease is an uncommon and severe symptom in childhood. Embolization can be a treatment option in children with abnormal vasculature bleeding and can be repeated safely when needed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Tugba Sismanlar, Ayse Tana Aslan, Koray Akkan, Emetullah Cindil, Baran Onal, Beyza Ozcan Tags: Review Article Source Type: research

Pneumomediastinum as a complication of critical pertussis
We report here a case of serologically confirmed pertussis in an 18‐year‐oldman presenting with pneumomediastinum, subcutaneous emphysema in the neck and chest, and persistent attacks of coughing with apnea that required treatment in the intensive care unit. Pneumomediastinum and subcutaneous emphysema have never been described in adult patients with pertussis. Physicians should be aware that patients presenting with persistent cough and pneumomediastinum may have pertussis and include this in their differential diagnosis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Francesco Monaco, Mario Barone, Valeria Graziella Manfredi, Rosario Marando, Flavia Nunnari, Antonio David, Maurizio Monaco, Antonio Cascio Tags: Original Article Source Type: research

Myeloid Sarcoma: an unusual presentation for acute tracheal stenosis
Abstract Extramedullary involvement of acute myelogenous leukemia (AML) is rare and has been reported under the terms myeloid sarcoma (MS), granulocytic sarcoma, chloroma, extramedullary acute myeloid leukemia, myeloblastoma and myelosarcoma. The most common extramedullary involvement includes soft tissues and lymph nodes but it may arise in different sites of the body. There are only very few reports about myeloid sarcoma in the pulmonary system and involvement of the trachea is extremely rare. This is the first report of initial presentation of myeloid sarcoma by severe acute tracheal stenosis. After failed tracheal dila...
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Eitan Podgeatz, Mark Kriegsmann, H. Erhan Dincer, James S. Allan Tags: Other Source Type: research

Early Versus Late Tracheostomy in Critically Ill Patients: A Systematic Review and Meta‐Analysis
CONCLUSIONSOur meta‐analysis suggested that ET might be able to reduce the duration of sedation but did not significantly alter the mortality, incidence of VAP, duration of MV and length of ICU stay. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: L Meng, CM Wang, JX Li, J Zhang Tags: Review Article Source Type: research

Clinical analysis of patients with primary ciliary dyskinesia in mainland China
ConclusionsBeing a rare disease and easily confused with uncomplicated bronchiectasis, PCD diagnosis warrants particular attention. Recurrent respiratory infection, especially situs inversus could be the most important indicator of this disease. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Yueqin Cao, Changzhou Shao, Yuanlin Song, Chunxue Bai, Lixian He Tags: Original Article Source Type: research

Etiology and risk factors of community‐acquired pneumonia in hospitalized patients in Norway
ConclusionOur results indicate that S. pneumoniae is the most common bacterial cause of pneumonia in hospitalized patients, and the prevalence of Legionella pneumonia is probably higher in Norway than recognized previously. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 12, 2015 Category: Respiratory Medicine Authors: Wenche Røysted, Øystein Simonsen, Andrew Jenkins, Marjut Sarjomaa, Martin Veel Svendsen, Eivind Ragnhildstveit, Yngvar Tveten, Anita Kanestrøm, Halfrid Waage, Jetmund Ringstad Tags: Original Article Source Type: research

Adherence to evidence-based secondary prevention pharmacotherapy in patients after an acute coronary syndrome: A systematic review
Conclusions Adherence to secondary prevention pharmacotherapy was suboptimal in patients after hospital discharge for an ACS. Risk factors associated with non-adherence were examined in a limited number of studies, and the associations varied between these investigations. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - March 12, 2015 Category: Respiratory Medicine Source Type: research

A sanguineous pleuro pericardial effusion in a patient recently treated with Dabigatran
We describe, in the same patient, a sanguineous pleuro pericardial effusion that was diagnosed incidentally on a pre-ablation cardiac CT angiography. The diagnosis was made approximately two months after initiating Dabigatran treatment for non-valvular atrial fibrillation in a 63-year-old patient. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - March 12, 2015 Category: Respiratory Medicine Source Type: research

The safety and tolerability of oral AZD5069, a selective CXCR2 antagonist, in patients with moderate-to-severe COPD
Conclusions AZD5069 was well tolerated overall in those patients who completed study treatment, with no increase in infection rates in either dosage group compared with placebo. Further studies with AZD5069 appear to be warranted. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Brain natriuretic peptide modulates calcium homeostasis and epidermal growth factor receptor gene signalling in asthmatic airways smooth muscle cells
This study provides evidence that the effect of BNP on relaxing bronchial in ASM cells is mediated from epithelium and associates to rapid changes of EGFR and calcium homeostasis-associated gene levels. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Vitamin D as an adjunctive therapy in asthma. Part 2: A review of human studies
Publication date: Available online 5 March 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Conor P. Kerley , Basil Elnazir , John Faul , Liam Cormican Vitamin D deficiency (VDD) is highly prevalent worldwide, with adverse effects on bone health but also potentially other unfavorable consequences. VDD and asthma-incidence/severity share many common risk factors, including winter season, industrialization, poor diet, obesity, dark skin pigmentation, and high latitude. Multiple anatomical areas relevant to asthma contain both the enzyme responsible for producing activated vitamin D and the vitamin D rec...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Geranylgeranylacetone ameliorates lung ischemia/reperfusion injury by HSP70 and thioredoxin redox system: NF-kB pathway involved
Publication date: Available online 3 March 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Weijun Cao , Manhui Li , Jianxiong Li , Chengwei Li , Xin Xu , Weiqing Gu Geranylgeranylacetone (GGA) has been clinically used as an anti-ulcer drug. In the present study, we explored the protective effects of GGA on lung ischemia/reperfusion injury (IRI) and the underlying mechanism. The results demonstrated that GGA ameliorated the lung biochemical and histological alterations induced by IRI, which was reversed by HSP70 inhibition. To further explore the mechanism of GGA action, we focused on NF-kB and thiore...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms
Publication date: Available online 28 February 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Conor P. Kerley , Basil Elnazir , John Faul , Liam Cormican Vitamin D deficiency (VDD) is highly prevalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Assessing the clinical value of fast onset and sustained duration of action of long-acting bronchodilators for COPD
Publication date: Available online 26 February 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Mario Cazzola , Kai M. Beeh , David Price , Nicolas Roche The long-acting inhaled bronchodilators available for use in chronic obstructive pulmonary disease (COPD) vary in their pharmacological class (β2-adrenergic agonist or antimuscarinic/anticholinergic, alone or combined), durations of action and speed of onset of bronchodilator effect. In the early stages of development of a maintenance bronchodilator, the goals are to identify a molecule with the theoretically ‘ideal’ profile of fast onset and pr...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Budesonide increases TLR4 and TLR2 expression in Treg lymphocytes of allergic asthmatics
Conclusions Budesonide potentiates the activity of Treg by increasing TLR4, TLR2 and IL-10 expression. This event is associated to the decreased release of IL-6 and TNF-α in PBMC treated with budesonide. These findings shed light on new mechanisms by which corticosteroids, drugs widely used for the clinical management of bronchial asthma, control T lymphocyte activation. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?
Publication date: Available online 24 February 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Nicola Scichilone , Alida Benfante , Marialuisa Bocchino , Fulvio Braido , Pierluigi Paggiaro , Alberto Papi , Pierachille Santus , Alessandro Sanduzzi Inhalation is the preferred route of drug administration in chronic respiratory diseases because it optimises delivery of the active compounds to the targeted site and minimises side effects from systemic distribution. The choice of a device should be made after careful evaluation of the patient's clinical condition (degree of airway obstruction, comorbiditi...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

CXCR1/CXCR2 antagonist CXCL8(3-74)K11R/G31P blocks lung inflammation in swine barn dust-instilled mice
In this study we test the ability of a CXCR1/CXCR2 antagonist, CXCL8(3-74)K11R/G31P (G31P) to block many of the features of lung-inflammation in response to challenge with SBE in an established mouse exposure system. Injection of G31P concurrent with SBE nasal instillation over a course of 3 weeks significantly reduced neutrophil accumulation in the lungs of barn dust exposed animals compared to those given SBE alone. There was a similar reduction in pro-inflammatory cytokines and chemokines IL-6, KC, and MIP-2 in SBE plus G31P-treated mice. In addition to excreted products, the receptors ICAM-1, CXCR1, and CXCR2, which al...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Adult and paediatric cough guidelines: Ready for an overhaul?
Publication date: Available online 11 February 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Surinder S. Birring , Joanne Kavanagh , Kefang Lai , Anne B. Chang Cough is one of the most common reasons that patients seek medical attention. Cough guidelines from numerous countries and societies are available to assist the clinician to investigate and manage patients with cough. We review some of the recent progress in the field of cough that may lead to revision of these guidelines. In adults with chronic cough, new causes such as obstructive sleep apnoea have been identified. A new terminology, cough...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Aminophylline increases respiratory muscle activity during hypercapnia in humans
Conclusion Aminophylline administered at the usual clinical therapeutic dose increases ventilation and EMG activity of both inspiratory and expiratory muscles during hypercapnia in healthy humans. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size
Conclusions The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Agonist-induced β2-adrenoceptor desensitization and downregulation enhance pro-inflammatory cytokine release in human bronchial epithelial cells
Publication date: February 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 30 Author(s): Susanne Oehme , Anja Mittag , Wieland Schrödl , Attila Tarnok , Karen Nieber , Getu Abraham It is not clear whether increased asthma severity associated with long-term use of β2-adrenoceptor (β2-AR) agonists can be attributed to receptor degradation and increased inflammation. We investigated the cross-talk between β-AR agonist-mediated effects on β2-AR function and expression and cytokine release in human bronchial epithelial cells. In 16HBE14o− cells grown in the presence and absence of β-AR agonists and/o...
Source: Pulmonary Pharmacology and Therapeutics - March 12, 2015 Category: Respiratory Medicine Source Type: research

Liquid fluorocarbon lavage to clear thrombus from the distal airways after severe pulmonary hemorrhage requiring ECLS
We report a patient on extracorporeal life support with massive pulmonary hemorrhage resulting in extensive alveolar and airway thrombus extending well beyond the proximal airways and the novel use of perfluorodecalin lavage to facilitate airway clearance and lung recruitment. Clinical Trial Registration None. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - March 12, 2015 Category: Respiratory Medicine Source Type: research

Correlations between osteoprotegerin serum levels and body composition parameters in patients with sleep apnea syndrome and the possible influence on cardiovascular risk
Conclusion Our findings, combined with previous observations in other diseases, suggest that elevated OPG serum levels together with selected body composition parameters may be helpful in identifying OSA patients with increased cardiovascular risk. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - March 12, 2015 Category: Respiratory Medicine Source Type: research

Constrictive bronchiolitis, two clinical reports
Publication date: Available online 11 March 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): D. Madama , A. Silva , S. Freitas , F. Gamboa (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - March 12, 2015 Category: Respiratory Medicine Source Type: research

Lung adenocarcinoma: Sustained subtyping with immunohistochemistry and EGFR, HER2 and KRAS mutational status
Publication date: Available online 11 March 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): Vitor Sousa , Carolina Rodrigues , Maria Silva , Ana Maria Alarcão , Lina Carvalho Pulmonary adenocarcinomas are still in the process of achieving morphological, immunohistochemical and genetic standardization. The ATS/ERS/IASLC proposed classification for lung adenocarcinomas supports the value of the identification of histological patterns, specifically in biopsies. Thirty pulmonary adenocarcinomas were subjected to immunohistochemical study (CK7, CK5, 6, 18, CK20, TTF1, CD56, HER2, EGFR and Ki-67), F...
Source: Revista Portuguesa de Pneumologia - March 12, 2015 Category: Respiratory Medicine Source Type: research

Longitudinal change in collagen degradation biomarkers in idiopathic pulmonary fibrosis: an analysis from the prospective, multicentre PROFILE study
Publication date: Available online 12 March 2015 Source:The Lancet Respiratory Medicine Author(s): R Gisli Jenkins , Juliet K Simpson , Gauri Saini , Jane H Bentley , Anne-Marie Russell , Rebecca Braybrooke , Philip L Molyneaux , Tricia M McKeever , Athol U Wells , Aiden Flynn , Richard B Hubbard , Diana J Leeming , Richard P Marshall , Morten A Karsdal , Pauline T Lukey , Toby M Maher Background Idiopathic pulmonary fibrosis, a progressive and inevitably fatal disorder, has a highly variable clinical course. Biomarkers that reflect disease activity are urgently needed to inform patient management and for use as biomarke...
Source: The Lancet Respiratory Medicine - March 12, 2015 Category: Respiratory Medicine Source Type: research

Biomarkers in idiopathic pulmonary fibrosis: picking the winners for trials
Publication date: Available online 12 March 2015 Source:The Lancet Respiratory Medicine Author(s): Michael G Crooks , Simon P Hart (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - March 12, 2015 Category: Respiratory Medicine Source Type: research