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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Management of tracheal chondrosarcoma almost completely obstructing the airway: a case report
Primary malignant tracheal tumors account for only 0.2 % of all malignancies of the respiratory tract. Tracheal chondrosarcoma is a rare condition and only 17 cases have been described in the literature from 1... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - July 11, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Marco Andolfi, Maurizio Vaccarili, Roberto Crisci and Francesco Puma Source Type: research

Risk factors for an acute exacerbation of idiopathic pulmonary fibrosis
Acute exacerbations of idiopathic pulmonary fibrosis are major causes of morbidity and mortality among patients with idiopathic pulmonary fibrosis. However, acute exacerbations remain unpredictable. The aim of... (Source: Respiratory Research)
Source: Respiratory Research - July 11, 2016 Category: Respiratory Medicine Authors: Tomoyuki Kakugawa, Noriho Sakamoto, Shuntaro Sato, Hirokazu Yura, Tatsuhiko Harada, Shota Nakashima, Atsuko Hara, Keishi Oda, Hiroshi Ishimoto, Kazuhiro Yatera, Yuji Ishimatsu, Yasushi Obase, Shigeru Kohno and Hiroshi Mukae Source Type: research

Risk factors for mortality in patients admitted to intensive care units with pneumonia
Despite the high mortality in patients with pneumonia admitted to an ICU, data on risk factors for death remain limited. (Source: Respiratory Research)
Source: Respiratory Research - July 11, 2016 Category: Respiratory Medicine Authors: Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Lauzier Francois, Andreas P. Freitag and Mitchell A. H. Levine Source Type: research

Paraparetic Guillain‐Barré syndrome: Non‐demyelinating reversible conduction failure restricted to the lower limbs
Conclusions: These findings suggest that patients with paraparetic GBS have axonal neuropathy, which is restricted to the lower limbs. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - July 11, 2016 Category: Internal Medicine Authors: Takeshi Kimachi, Nobuhiro Yuki, Norito Kokubun, Shuhei Yamaguchi, Benjamin R. Wakerley Tags: Case of the Month Source Type: research

IJERPH, Vol. 13, Pages 694: Health Impact Assessment of Air Pollution in São Paulo, Brazil
This study evaluates air pollution scenarios considering a Health Impact Assessment approach in São Paulo, Brazil. We have analyzed abatement scenarios of Particulate Matter (PM) with an aerodynamic diameter <10 μm (PM10), <2.5 μm (PM2.5) and ozone concentrations and the health effects on respiratory and cardiovascular morbidity and mortality in the period from 2009 to 2011 through the APHEKOM tool, as well as the associated health costs. Considering World Health Organization (WHO) standards of PM2.5 (10 μg/m3), São Paulo would avoid more than 5012 premature deaths (equivalent to 266,486 life years’ ga...
Source: International Journal of Environmental Research and Public Health - July 11, 2016 Category: Environmental Health Authors: Karina AbeSimone Miraglia Tags: Article Source Type: research

Outcome After Pneumonectomy in 17 Dogs and 10 Cats: A Veterinary Society of Surgical Oncology Case Series
ConclusionBased on this case series, right and left pneumonectomy can be performed with low perioperative mortality in dogs and cats, with some animals experiencing prolonged survival. (Source: Veterinary Surgery)
Source: Veterinary Surgery - July 11, 2016 Category: Veterinary Research Authors: Vincent Wavreille, S. E. Boston, C. Souza, K. Ham, G. Chanoit, D. Rossetti, J. Takacs, R. Milner Tags: Original Article ‐ Clinical Source Type: research

A systematic review of factors affecting intended and actual adherence with antiviral medication as treatment or prophylaxis in seasonal and pandemic flu
ConclusionPredictors identified in this review can be used to help inform communications in order to increase adherence to antivirals in both seasonal and pandemic influenza.This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - July 11, 2016 Category: Virology Authors: Louise E Smith, Donatella D'Antoni, Vageesh Jain, Julia M Pearce, John Weinman, G James Rubin Tags: Formal Systematic Review Source Type: research

Hypoxaemia in Mozambican children
ConclusionsClinical signs alone or in combination are not suitable to diagnose hypoxaemia. The use of pulse oximeters should be strongly encouraged. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - July 11, 2016 Category: Tropical Medicine Authors: Quique Bassat, Miguel Lanaspa, Sónia Machevo, Cristina O'Callaghan‐Gordo, Lola Madrid, Tacilta Nhampossa, Sozinho Acácio, Anna Roca, Pedro L. Alonso Tags: Original Article Source Type: research

Vaccine Development Against Middle East Respiratory Syndrome
Abstract Various types of vaccines are under pre-clinical and clinical development to address the recent appearance of Middle East respiratory syndrome or MERS, an emerging infectious disease that has already caused over 600 deaths and remains a threat to world health. The causative agent for this respiratory disease is a member of the betacoronavirus genus, phylogenetically closely related to the SARS coronavirus that caused an international health emergency in 2002. With lessons learned from the outbreak of severe acute respiratory syndrome, and with undeniable technological advances, vaccine development against...
Source: Current Tropical Medicine Reports - July 11, 2016 Category: Tropical Medicine Source Type: research

The impact of adherence to inhaled drugs on 5‐year survival in COPD patients: a time dependent approach
ConclusionsThese findings support clinical guidelines and recommendations for the regular use of inhaled drugs to improve health status and prognosis among moderate–severe COPD patients. © 2016 The Authors. Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 11, 2016 Category: Drugs & Pharmacology Authors: Valeria Belleudi, Mirko Di Martino, Silvia Cascini, Ursula Kirchmayer, Riccardo Pistelli, Giulio Formoso, Danilo Fusco, Marina Davoli, Nera Agabiti, Tags: Original Report Source Type: research

An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma
In this study, an accurate, sensitive, rapid, and reliable bioanalytical method was developed for the determination of hederacoside C in rat plasma using ultra high-performance liquid chromatography-tandem mass spectrometry (UPLC–MS/MS). For sample preparation, plasma proteins were precipitated with 0.1% acetic acid in acetonitrile. Waters UPLC BEH C18 (2.1mm I.D.×100mm, 1.7μm) column was used for chromatographic separation. A gradient elution of mobile phases consisting of 0.02% acetic acid in distilled water (solvent A) and 0.02% acetic acid in acetonitrile (solvent B) was used at a flow rate of 0.3mL/min. The multip...
Source: Journal of Pharmaceutical and Biomedical Analysis - July 11, 2016 Category: Drugs & Pharmacology Source Type: research

Subgroup analysis of Asian patients in the INPULSIS® trials of nintedanib in idiopathic pulmonary fibrosis
ConclusionIn pre‐specified subgroup analyses of Asian versus White patients with IPF in the INPULSIS® trials, race did not influence the effect of nintedanib on disease progression. (Source: Respirology)
Source: Respirology - July 11, 2016 Category: Respiratory Medicine Authors: Hiroyuki Taniguchi, Zuojun Xu, Arata Azuma, Yoshikazu Inoue, Huiping Li, Tsuyoshi Fujimoto, Zelie Bailes, Rozsa Schlenker‐Herceg, Dong S. Kim Tags: Original Article Source Type: research

Development and Validation of the COMPLES Score for Differentiating Between Tuberculous Effusions with Low Pleural pH or Glucose and Complicated Parapneumonic Effusions
Conclusions CPE is not an unusual presentation of tuberculosis. A simple new scoring system provides a reliable tool for differentiating between CTPE and CPPE. (Source: Lung)
Source: Lung - July 11, 2016 Category: Respiratory Medicine Source Type: research

Bridging the etiologic and prognostic outlooks in individualized assessment of absolute risk of an illness: application in lung cancer
Abstract Assessment of individual risk of illness is an important activity in preventive medicine. Development of risk-assessment models has heretofore relied predominantly on studies involving follow-up of cohort-type populations, while case–control studies have generally been considered unfit for this purpose. To present a method for individualized assessment of absolute risk of an illness (as illustrated by lung cancer) based on data from a ‘non-nested’ case–control study. We used data from a case–control study conducted in Montreal, Canada in 1996–2001. Individuals diagnosed with lung cancer (n =...
Source: European Journal of Epidemiology - July 11, 2016 Category: Epidemiology Source Type: research

An investigation on the effect of improved X-rays-guided radiofrequency thermocoagulation denervation on lumbar facet joint syndrome
An increasing number of adults suffer from low back pain, which ranks second to upper respiratory problems as a symptom-related reason for visits to a physician [1,2]. Experimental studies have suggested that low back pain may originate from many spinal structures, and the pain from the lumbar facet joints affects up to 15% of patients with chronic low back pain [3]. Lumbar facet joints refer to degenerative changes caused by trauma or congenital dysplasia from lumbar facet joint instability, which leads to lumbago and limited mobility. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - July 11, 2016 Category: Neurosurgery Authors: Qin Zhou Ms, Fang Zhou, Long Wang, Kang Liu Source Type: research

Distribution-Based Estimates of Minimal Important Difference for Hospital Anxiety and Depression Scale and Impact of Event Scale-Revised in Survivors of Acute Respiratory Failure
This study will estimate distribution-based minimal important difference (MID) for the Hospital Anxiety and Depression Scale anxiety (HADS-A) and depression (HADS-D) subscales, and the Impact of Event Scale-Revised IES-R in survivors of acute respiratory failure (ARF). (Source: General Hospital Psychiatry)
Source: General Hospital Psychiatry - July 11, 2016 Category: Psychiatry Authors: Kitty S. Chan, Lisa Aronson Friedman, O. Joseph Bienvenu, Victor D. Dinglas, Brian H. Cuthbertson, Richard Porter, Christina Jones, Ramona O. Hopkins, Dale M. Needham Source Type: research

Development of a Novel Quantitative Structure-Activity Relationship Model to Accurately Predict Pulmonary Absorption and Replace Routine Use of the Isolated Perfused Respiring Rat Lung Model
Conclusions The novel QSAR model described here can replace routine generation of IPRLu model data for ranking and classifying compounds prior to synthesis. It will also provide scientists working in the field of inhaled drug discovery with a deeper understanding of the physicochemical drivers of pulmonary absorption based on a relevant respiratory compound dataset. (Source: Pharmaceutical Research)
Source: Pharmaceutical Research - July 11, 2016 Category: Drugs & Pharmacology Source Type: research

Etiology and long-term functional swallow outcomes in pediatric unilateral vocal fold immobility
Unilateral vocal fold immobility (UVFI) results in deficits in phonatory, respiratory, and swallow function of the pediatric patient. Little is known about long-term functional swallow outcomes. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - July 11, 2016 Category: ENT & OMF Authors: Kathleen M. Tibbetts, Derek Wu, Jeffrey V. Hsu, William B. Burton, Michel Nassar, Melin Tan Source Type: research

Effectiveness of the Assessment of Burden of COPD (ABC) tool on health-related quality of life in patients with COPD: a cluster randomised controlled trial in primary and hospital care
Conclusions This study showed that use of the ABC tool may increase quality of life and perceived quality of care. Trial registration number NTR3788; Results. (Source: BMJ Open)
Source: BMJ Open - July 11, 2016 Category: Journals (General) Authors: Slok, A. H. M., Kotz, D., van Breukelen, G., Chavannes, N. H., Rutten-van Mölken, M. P. M. H., Kerstjens, H. A. M., van der Molen, T., Asijee, G. M., Dekhuijzen, P. N. R., Holverda, S., Salome, P. L., Goossens, L. M. A., Twellaar, M., in 't Veen, Tags: Open access, Patient-centred medicine, Respiratory medicine Research Source Type: research

Clinical Reasoning: A tale of a hypotonic infant
An 11-month-old girl was referred to our center for evaluation of hypotonia and developmental delays. She was born at term via cesarian delivery because of breech presentation. Fetal movements were reduced during pregnancy. Delivery and immediate postnatal events were uneventful. Her birth weight was low (2.5 kg). However, at 4 hours of life, she developed respiratory distress requiring intubation. She had 2 brief episodes of right upper extremity twitching on day one following intubation without further recurrence. She was extubated after 4 days. She had significant swallowing dysfunction requiring nasogastric tube feedin...
Source: Neurology - July 11, 2016 Category: Neurology Authors: Al-Ghamdi, F., Ghosh, P. S. Tags: All Clinical Neurology, All Pediatric, Neonatal RESIDENT AND FELLOW SECTION Source Type: research

New Vaccines on the Horizon
Abstract Purpose of Review Well-established as a powerful tool for preventing disease, vaccines have immeasurably impacted health and disease epidemiology worldwide. In the era of rational vaccine design and ever-evolving technology, vaccine development and delivery is poised to improve the ability to target a range of new diseases and to improve disease prevention, in even the most remote communities worldwide. Recent Findings New vaccines against influenza, human papillomavirus and meningococcal diseases have focused on targeting an increased number of...
Source: Current Pediatrics Reports - July 11, 2016 Category: Pediatrics Source Type: research

A naturally truncated NS1 protein of influenza A virus impairs its interferon-antagonizing activity and thereby confers attenuation in vitro
Abstract The non-structural protein of influenza A virus (NS1A protein) is a multifunctional protein that antagonizes host antiviral responses and contributes to efficient viral replication during infection. However, most of its functions have been elucidated by generating recombinant viruses expressing mutated NS1 proteins that do not exist in nature. Recently, the novel H3N8 A/Equine/Kyonggi/SA1/2011 (KG11) influenza virus was isolated in Korea from horses showing respiratory disease symptoms. KG11 virus contains a naturally truncated NS gene segment with the truncation in the NS1A coding region, resulting in tr...
Source: Archives of Virology - July 11, 2016 Category: Virology Source Type: research

Deglutition and respiratory patterns during sleep in the aged.
CONCLUSION: Deglutition was extremely infrequent and displayed unique patterns during sleep in the aged. OBJECTIVES: The deglutition and respiratory phase patterns during sleep in the healthy aged were investigated in this study. METHODS: Ten aged adults (average age = 71 years) were examined via time-matched digital recordings of polysomnography and surface electromyography of the muscles (thyrohyoid and suprahyoid muscles) related to swallowing. RESULTS: During sleep, swallowing was extremely infrequent and absent for long periods in the aged. The median number of swallows per hour during total sleep time w...
Source: Acta Oto-Laryngologica - July 11, 2016 Category: ENT & OMF Authors: Sato K, Chitose SI, Sato K, Umeno H Tags: Acta Otolaryngol Source Type: research

Pharyngeal constrictor muscle fatty change may contribute to obstructive sleep apnea-hypopnea syndrome: a prospective observational study.
CONCLUSIONS: Pharyngeal constrictor muscle injury and fatty changes may play important roles in the pathogenesis and progression of OSAHS. OBJECTIVE: Obstructive sleep apnea-hypopnea syndrome (OSAHS) is a respiratory disorder caused by upper airway obstruction during sleep. The primary objectives of this study were to determine the ultrastructural characteristics of the pharyngeal constrictor muscle in patients with OSAHS. METHODS: A pharyngeal constrictor muscle specimen was collected from all subjects. The muscle cell ultrastructure was observed under electron microscopy. RESULTS: Eighteen male patients with ...
Source: Acta Oto-Laryngologica - July 11, 2016 Category: ENT & OMF Authors: Shi L, Wang H, Wei L, Hong Z, Wang M, Wang Z Tags: Acta Otolaryngol Source Type: research

Protection of chickens vaccinated with combinations of commercial live infectious bronchitis vaccines containing Massachusetts, Dutch and QX-like serotypes against challenge with virulent infectious bronchitis viruses 793B and IS/1494/06 Israel variant 2.
Abstract Infectious bronchitis virus (IBV) is a coronavirus which affects chickens of all ages. IBV mainly causes respiratory disease but can also result in reduced weight, reduced egg production, increased frequency of abnormal eggs and increased rates of mortality. Vaccination is the most important way to control the disease. Nevertheless, novel strains of IB continue to emerge in the field. In order to promptly respond, combinations of existing IB vaccines are frequently tested whether can provide cross-protection. The efficacy of a combination of vaccines based on Massachusetts, Dutch and QX-like IB strains aga...
Source: Avian Pathology - July 11, 2016 Category: Pathology Authors: Bru T, Vila R, Cabana M, Geerligs HJ Tags: Avian Pathol Source Type: research

Cost effectiveness of amoxicillin for lower respiratory tract infections in primary care: an economic evaluation accounting for the cost of antimicrobial resistance.
CONCLUSION: Economic evaluation of antibiotic prescribing strategies that do not include the cost of resistance may provide misleading results that could be of questionable use to policymakers. However, further work is required to estimate robust costs of resistance. PMID: 27402969 [PubMed - as supplied by publisher] (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - July 11, 2016 Category: Primary Care Authors: Oppong R, Smith RD, Little P, Verheij T, Butler CC, Goossens H, Coenen S, Moore M, Coast J Tags: Br J Gen Pract Source Type: research

Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis.
Abstract Septic shock is a major cause of death worldwide and a considerable healthcare burden in the 21st century. Recently, attention shifted from damaging effects of the pro-inflammatory response to the detrimental role of anti-inflammation, a phenomenon known as sepsis-induced immunoparalysis. Sepsis-induced immunoparalysis may render patients vulnerable to secondary infections and is associated with impaired outcome. The immunoparalysis hypothesis compels us to re-evaluate the current management of septic shock and assess whether we are inadvertently compromising or altering the host immune response. In this p...
Source: American Journal of Respiratory and Critical Care Medicine - July 11, 2016 Category: Respiratory Medicine Authors: Stolk RF, van der Poll T, Angus DC, van der Hoeven JG, Pickkers P, Kox M Tags: Am J Respir Crit Care Med Source Type: research

Molecular Medicine of Pulmonary Arterial Hypertension: From Population Genetics to Precision Medicine and Gene Editing.
Abstract The majority of the remarkable progress in understanding the molecular pathogenesis of Pulmonary Arterial Hypertension has been achieved within the past 2 decades. But despite important advances in treatment, PAH remains a disease with poor survival and no curative therapy. A rapidly growing molecular knowledge base provides hope for the possibility to develop specific therapies targeted at the origins of disease, as well as factors which modify therapeutic response. In this synopsis, we summarize highlights of the genetic basis of PAH, and the evolving fields of prediction of disease risk, its course, and...
Source: American Journal of Respiratory and Critical Care Medicine - July 11, 2016 Category: Respiratory Medicine Authors: Austin ED, West J, Loyd JE, Hemnes AR Tags: Am J Respir Crit Care Med Source Type: research

Non-prescription antimicrobial use in a primary care population in the United States: evidence for action.
Abstract Community antimicrobial resistance is high in communities with frequent use of non-prescription antibiotics. Studies addressing non-prescription antibiotic use in the United States (US) have been restricted to Latin American immigrants. We estimated the prevalence of non-prescription antibiotic use in the previous 12 months, as well as intended use (intention to use antibiotics without a prescription) and storage of antibiotics, and examined patient characteristics associated with non-prescription use in a random sample of adults.We selected private and public primary care clinics that serve ethnically and...
Source: Antimicrobial Agents and Chemotherapy - July 11, 2016 Category: Microbiology Authors: Zoorob R, Grigoryan L, Nash S, Trautner BW Tags: Antimicrob Agents Chemother Source Type: research

Prospectives of Antihypertensive Nano-ceuticals as Alternative Therapeutics.
Abstract Global death rate due to cardiovascular diseases (CVDs) is highest as compared to other ailments. Principal risk factor associated with CVDs is hypertension. Major classes of current antihypertensive (AHT) therapies include angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARBs) and calcium channel blockers (CCBs). All these antihypertensive therapeutic drugs have low oral bioavailability and can induce upper respiratory tract abstraction, angioedema, reflex tachycardia and extreme hypotensive effect after oral administration which can cause lethal effects in patients with hea...
Source: Current Drug Targets - July 11, 2016 Category: Drugs & Pharmacology Authors: Niaz T, Hafeez Z, Imran M Tags: Curr Drug Targets Source Type: research

Chylothorax in paracoccidioidomycosis.
CHYLOTHORAX IN PARACOCCIDIOIDOMYCOSIS. Rev Inst Med Trop Sao Paulo. 2016 Jul 11;58 Authors: Fernandes FF, Alves VO, Sánchez TE, Paula WD, Santana AN Abstract A previously healthy, 52-year-old woman presented with a nine months history of low fever and weight loss (> 30 kg). Physical examination disclosed generalized lymphadenopathy, skin lesions, abdominal distension, mild tachypnea and a left breast mass. Laboratory tests showed anemia; (prerenal) kidney injury, low serum albumin level; and negative serology for HIV and viral hepatitis. Computed tomography (neck/chest/abdomen) showed generalized l...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - July 11, 2016 Category: Tropical Medicine Authors: Fernandes FF, Alves VO, Sánchez TE, Paula WD, Santana AN Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Clinical characteristics, outcomes and risk factors for death among critically ill patients with hiv-related acute kidney injury.
CONCLUSION: Non-survivor HIV-infected patients with AKI admitted to the ICU presented higher severity APACHE II scores, more respiratory damage and hemodynamic impairment than survivors. Septic shock and respiratory insufficiency were independently associated to death. PMID: 27410912 [PubMed - in process] (Source: Revista do Instituto de Medicina Tropical de Sao Paulo)
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - July 11, 2016 Category: Tropical Medicine Authors: Luna LD, Soares Dde S, Junior GB, Cavalcante MG, Malveira LR, Meneses GC, Pereira ED, Daher Ede F Tags: Rev Inst Med Trop Sao Paulo Source Type: research

Breathing and affective picture processing across the adult lifespan.
Abstract The present study investigated differences between healthy younger, middle-aged, and older adults in their respiratory responses to pictures of different valence and arousal. Expiratory time shortened and end-tidal PCO2 decreased with increasing arousal in all age groups; yet, compared to younger adults, older adults' overall change from baseline was smaller for expiratory time and larger for end-tidal PCO2. Contrary to their younger counterparts, older adults' inspiratory time did not shorten with increasing arousal. Inspiratory duty cycle did not covary with affective ratings for younger adults, increase...
Source: Biological Psychology - July 11, 2016 Category: Psychiatry & Psychology Authors: Gomez P, Filippou D, Pais B, Gunten AV, Danuser B Tags: Biol Psychol Source Type: research

[Impact of telmisartan on glomerular filtration in laparoscopic surgery. A double blinded randomised controlled study].
CONCLUSION: The use of telmisartan, an angiotensin II AT1 receptor antagonist, offers renal protection during laparoscopic surgery. PMID: 27417705 [PubMed - as supplied by publisher] (Source: Cirugia y Cirujanos)
Source: Cirugia y Cirujanos - July 11, 2016 Category: Surgery Authors: Fuentes-Reyes RA, Pacheco-Patiño MF, Ponce-Escobedo AN, Muñoz-Maldonado GE, Hernandez-Guedea MA Tags: Cir Cir Source Type: research

Clinical and microbiological epidemiology of early and late infectious complications among solid ‐organ transplant recipients requiring hospitalization
This study reports on the rate and timing of these syndromes and describes the associated microbiological epidemiology. This prevalence cohort study evaluated solid‐organ transplant recipients requiring hospitalization during 2007–2011. We reported infectious complications requiring hospitalization in 603 of 1414 readmissions at a rate of 0.43 episodes per 1000 transplant‐days (95% CI, 0.40–0.47), with 85% occurring >6 months post‐transplantation. The most frequent infectious complications were as follows: respiratory (27%), sepsis or bacteremia (13%), liver or biliary tract (12%), genitourinary (12%), and cyt...
Source: Transplant International - July 11, 2016 Category: Transplant Surgery Authors: Bassem Hamandi, Shahid Husain, Paul Grootendorst, Emmanuel A. Papadimitropoulos Tags: Original Article Source Type: research

The impact of adherence to inhaled drugs on 5 ‐year survival in COPD patients: a time dependent approach
ConclusionsThese findings support clinical guidelines and recommendations for the regular use of inhaled drugs to improve health status and prognosis among moderate–severe COPD patients. © 2016 The Authors. Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd. © 2016 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 11, 2016 Category: Drugs & Pharmacology Authors: Valeria Belleudi, Mirko Di Martino, Silvia Cascini, Ursula Kirchmayer, Riccardo Pistelli, Giulio Formoso, Danilo Fusco, Marina Davoli, Nera Agabiti, Tags: Original Report Source Type: research

Serial procalcitonin levels for predicting prognosis in community ‐acquired pneumonia
ConclusionIt is useful to add serial measurements of PCT to CRP measurement and assessment of CURB‐65 on admission of CAP patients to predict prognosis and initial treatment failure. (Source: Respirology)
Source: Respirology - July 11, 2016 Category: Respiratory Medicine Authors: Akihiro Ito, Tadashi Ishida, Hiromasa Tachibana, Yuhei Ito, Takuya Takaiwa Tags: Original Article Source Type: research

Subgroup analysis of Asian patients in the INPULSIS ® trials of nintedanib in idiopathic pulmonary fibrosis
ConclusionIn pre‐specified subgroup analyses of Asian versus White patients with IPF in the INPULSIS® trials, race did not influence the effect of nintedanib on disease progression. (Source: Respirology)
Source: Respirology - July 11, 2016 Category: Respiratory Medicine Authors: Hiroyuki Taniguchi, Zuojun Xu, Arata Azuma, Yoshikazu Inoue, Huiping Li, Tsuyoshi Fujimoto, Zelie Bailes, Rozsa Schlenker ‐Herceg, Dong S. Kim Tags: Original Article Source Type: research

Paraparetic Guillain ‐Barré syndrome: Non‐demyelinating reversible conduction failure restricted to the lower limbs
Conclusions: These findings suggest that patients with paraparetic GBS have axonal neuropathy, which is restricted to the lower limbs. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - July 11, 2016 Category: Internal Medicine Authors: Takeshi Kimachi, Nobuhiro Yuki, Norito Kokubun, Shuhei Yamaguchi, Benjamin R. Wakerley Tags: Case of the Month Source Type: research

Altered Mitochondria, Protein Synthesis Machinery, and Purine Metabolism Are Molecular Contributors to the Pathogenesis of Creutzfeldt-Jakob Disease
Neuron loss, synaptic decline, and spongiform change are the hallmarks of sporadic Creutzfeldt–Jakob disease (sCJD), and may be related to deficiencies in mitochondria, energy metabolism, and protein synthesis. To investigate these relationships, we determined the expression levels of genes encoding subunits of the 5 protein complexes of the electron transport chain, proteins involved in energy metabolism, nucleolar and ribosomal proteins, and enzymes of purine metabolism in frontal cortex samples from 15 cases of sCJD MM1 and age-matched controls. We also assessed the protein expression levels of subunits of the res...
Source: Journal of Neuropathology and Experimental Neurology - July 11, 2016 Category: Neurology Authors: Ansoleaga, B., Garcia-Esparcia, P., Llorens, F., Hernandez-Ortega, K., Carmona, M., Antonio del Rio, J., Zerr, I., Ferrer, I. Tags: Original Articles Source Type: research

Susceptibility of the upper respiratory tract to influenza virus infection following desialylation.
Authors: Nicholls J, Chan M, Kwong D PMID: 27390002 [PubMed - as supplied by publisher] (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - July 10, 2016 Category: Journals (General) Tags: Hong Kong Med J Source Type: research

Comparative short-term inhalation toxicity of five organic diketopyrrolopyrrole pigments and two inorganic iron-oxide-based pigments.
Authors: Hofmann T, Ma-Hock L, Strauss V, Treumann S, Rey Moreno M, Neubauer N, Wohlleben W, Gröters S, Wiench K, Veith U, Teubner W, van Ravenzwaay B, Landsiedel R Abstract Diketopyrrolopyrroles (DPP) are a relatively new class of organic high-performance pigments. The present inhalation and particle characterization studies were performed to compare the effects of five DPP-based pigments (coarse and fine Pigment Red 254, coarse and fine meta-chloro DPP isomer and one form of mixed chlorinated DPP isomers) and compare it to coarse and fine inorganic Pigment Red 101. Wistar rats were exposed head-nose to atmospher...
Source: Inhalation Toxicology - July 10, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research