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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Improvements in lung function with umeclidinium/vilanterol versus fluticasone propionate/salmeterol in patients with moderate-to-severe COPD and infrequent exacerbations
Umeclidinium (UMEC; long-acting muscarinic antagonist [LAMA])/vilanterol (VI; long-acting beta2-agonist [LABA]) and fluticasone propionate/salmeterol (FP/SAL) (inhaled corticosteroid/LABA) are approved maintenance therapies for chronic obstructive pulmonary disease (COPD). Two studies compared efficacy and safety of UMEC/VI with FP/SAL in patients with moderate-to-severe COPD with no exacerbations in the previous year. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 7, 2015 Category: Respiratory Medicine Authors: James F. Donohue, Sally Worsley, Chang-Qing Zhu, Liz Hardaker, Alison Church Source Type: research

Engineering Escherichia coli for high-level production of propionate.
Abstract Mounting environmental concerns associated with the use of petroleum-based chemical manufacturing practices has generated significant interest in the development of biological alternatives for the production of propionate. However, biological platforms for propionate production have been limited to strict anaerobes, such as Propionibacteria and select Clostridia. In this work, we demonstrated high-level heterologous production of propionate under microaerobic conditions in engineered Escherichia coli. Activation of the native Sleeping beauty mutase (Sbm) operon not only transformed E. coli to be propionoge...
Source: Journal of Industrial Microbiology and Biotechnology - May 7, 2015 Category: Microbiology Authors: Akawi L, Srirangan K, Liu X, Moo-Young M, Perry Chou C Tags: J Ind Microbiol Biotechnol Source Type: research

Blood pressure lowering effect of the sodium glucose co-transporter-2 (SGLT2) inhibitor, ertugliflozin, assessed via ambulatory blood pressure monitoring (ABPM), in patients with type 2 diabetes and hypertension.
This study (NCT01096667) compared the blood pressure (BP)-lowering effect of ertugliflozin (1, 5, 25 mg), hydrochlorothiazide (HCTZ; 12.5 mg) and placebo in 194 patients with type 2 diabetes mellitus (T2DM) and hypertension for 4 weeks using ambulatory BP monitoring. Endpoints (change from baseline to week 4) were: 24-h mean systolic BP (SBP; primary); daytime, night-time, seated pre-dose SBP, 24-h, daytime, night-time, seated pre-dose diastolic BP, 24-h urinary glucose excretion, fasting plasma glucose (secondary). Safety/tolerability were monitored. Significant decreases in placebo-corrected 24-h mean SBP (-3.0 to -4...
Source: Diabetes Metab - May 7, 2015 Category: Endocrinology Authors: Amin NB, Wang X, Mitchell JR, Lee DS, Nucci G, Rusnak JM Tags: Diabetes Obes Metab Source Type: research

Increased airway reactivity in a neonatal mouse model of Continuous Positive Airway Pressure (CPAP).
CONCLUSION: These data may be important to our understanding of the potential long-term consequences of neonatal CPAP therapy used in the intensive care of preterm infants.Pediatric Research (2015); doi:10.1038/pr.2015.90. PMID: 25950451 [PubMed - as supplied by publisher] (Source: Pediatric Research)
Source: Pediatric Research - May 7, 2015 Category: Pediatrics Authors: Mayer CA, Martin RJ, MacFarlane PM Tags: Pediatr Res Source Type: research

Community-acquired pneumonia: Pathogenesis of acute cardiac events and potential adjunctive therapies.
Abstract ABSTRACT: Despite advances in antimicrobial chemotherapy and access to sophisticated intensive care facilities, bacterial community-acquired pneumonia (CAP) continues to carry an unacceptably high mortality rate of 10-15% in hospitalized cases. CAP, considered by many to be the most under-estimated disease worldwide, poses a particular threat to the elderly whose numbers are steadily increasing in developed countries. Indeed elderly patients with severe CAP, as well as those with other risk factors, are at significant risk for development of inflammation-mediated acute cardiac events which may undermine th...
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Feldman C, Anderson R Tags: Chest Source Type: research

Optimizing atrial fibrillation management: from ICU and beyond.
We describe various strategies for the assessment and long-term management of patients with new-onset AF during critical illness. PMID: 25951122 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Walkey AJ, Hogarth DK, Lip GY Tags: Chest Source Type: research

Which Patients with ARDS Benefit from Lung Biopsy?
Abstract Abstract: A central tenet to caring for patients with acute respiratory distress syndrome (ARDS) is to treat the underlying cause, be it sepsis, pneumonia, or removal of an offending toxin. Identifying the risk factor for ARDS has even been proposed as essential to diagnosing ARDS. Not infrequently, however, the precipitant for acute hypoxemic respiratory failure is unclear, and this raises the question of whether a histologic lung diagnosis would benefit the patient. In this review, we consider the historic role of pathology in establishing a diagnosis of ARDS and the published experience of surgical and ...
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Palakshappa JA, Meyer NJ Tags: Chest Source Type: research

Unraveling the Pathophysiology of the Asthma COPD Overlap Syndrome: Unsuspected mild centrilobular emphysema is responsible for loss of lung elastic recoil in never smoked asthmatics with persistent expiratory airflow limitation.
Abstract Investigators believe most asthmatics have reversible airflow obstruction with treatment, despite airway remodeling and hyperresponsiveness. There are smoking and non-smoking patients with chronic expiratory airflow obstruction despite treatment, who have features of both asthma and chronic obstructive pulmonary disease. Investigators refer to this conundrum as the Asthma COPD Overlap Syndrome (ACOS). Furthermore, a subset of treated, non-smoking moderate-to-severe asthmatics, have persistent expiratory airflow limitation, despite partial reversibility. It has been assumed to be due to large and especially...
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Gelb AF, Yamamoto A, Verbeken EK, Nadel JA Tags: Chest Source Type: research

The quality assessment of clinical practice guidelines for respiratory diseases in China: A systematic appraisal.
Conclusions: The quality of the guidelines was low, and stakeholder involvement, rigor of development, applicability and editorial independence should be considered in the future development of clinical practice guidelines for respiratory diseases in China. PMID: 25950752 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Jiang M, Liao LY, Liu XQ, He WQ, Guan WJ, Chen H, Li YM Tags: Chest Source Type: research

Lung-dominant connective tissue disease: clinical, radiologic and histologic features.
Conclusions: The major histologic patterns in LD-CTD were UIP followed by NSIP. Two-thirds of patients had characteristic histologic features for LD-CTD. A majority of h-UIP patients were considered to be unclassifiable IIP based on MDD. Patients with h-UIP had worse survival than those with h-NSIP. PMID: 25950648 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Omote N, Taniguchi H, Kondoh Y, Watanabe N, Sakamoto K, Kimura T, Kataoka K, Johkoh T, Fujimoto K, Fukuoka J, Otani K, Nishiyama O, Hasegawa Y Tags: Chest Source Type: research

The use of a fully automated automatic adaptive servo ventilation algorithm in the acute and chronic treatment of central sleep apnea.
Conclusions: The ASV device treated complex breathing disorders using automated algorithms. Compared to CPAP, patients reported improved sleep quality. Home use of ASV remained effective with acceptable adherence and improvements in daytime sleepiness. This trial was registered with (NCT01199042). PMID: 25950507 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Javaheri S, Winslow D, McCullough P, Wylie P, Kryger MH Tags: Chest Source Type: research

Effects of oropharyngeal exercises on snoring: a randomized trial.
Conclusions: Oropharyngeal exercises are effective in reducing objectively measured snoring and are a possible treatment for a large population suffering from snoring. Clinical trial registered with (NCT01636856). PMID: 25950418 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Ieto V, Kayamori F, Montes MI, Hirata RP, Gregório MG, Alencar AM, Drager LF, Genta PR, Lorenzi-Filho G Tags: Chest Source Type: research

Determinants of Underdiagnosis of COPD in national and international surveys.
Conclusion: Even with substantial heterogeneity in COPD prevalence, COPD underdiagnosis is universally high. Since effective management strategies are available for COPD, spirometry can help to diagnose COPD at a stage when treatment will lead to better outcomes and improved quality of life. PMID: 25950276 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Lamprecht B, Soriano JB, Studnicka M, Kaiser B, Vanfleteren L, Gnatiuc L, Burney P, Miravitlles M, García-Rio F, Akbari K, Ancochea J, Menezes AM, Perez-Padilla R, Montes de Oca M, Torres-Duque CA, Caballero A, González-García M, Buist S, BOLD Collabor Tags: Chest Source Type: research

Airway IL-1β and systemic inflammation as predictors of future exacerbation risk in asthma and COPD.
Conclusion: Airway IL-1β and systemic inflammation are associated with frequent exacerbations and may mediate a vicious cycle between previous and future exacerbations in COPD. Treatment strategies aimed at attenuating these inflammatory pathways to reduce COPD exacerbations deserve further investigation. PMID: 25950204 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 7, 2015 Category: Respiratory Medicine Authors: Fu JJ, McDonald VM, Baines KJ, Gibson PG Tags: Chest Source Type: research

High capacity for extracellular acid-base regulation in the air-breathing fish Pangasianodon hypophthalmus [SHORT COMMUNICATION]
Christian Damsgaard, Le Thi Hong Gam, Dang Diem Tuong, Phan Vinh Thinh, Do Thi Huong Thanh, Tobias Wang, and Mark Bayley The evolution of accessory air-breathing structures is typically associated with reduction of the gills, although branchial ion transport remains pivotal for acid–base and ion regulation. Therefore, air-breathing fishes are believed to have a low capacity for extracellular pH regulation during a respiratory acidosis. In the present study, we investigated acid–base regulation during hypercapnia in the air-breathing fish Pangasianodon hypophthalmus in normoxic and hypoxic water at 28–30&d...
Source: Journal of Experimental Biology - May 7, 2015 Category: Biology Authors: Damsgaard, C., Gam, L. T. H., Tuong, D. D., Thinh, P. V., Huong Thanh, D. T., Wang, T., Bayley, M. Tags: SHORT COMMUNICATION Source Type: research

Novel Nsp2 deletion based on molecular epidemiology and evolution of porcine reproductive and respiratory syndrome virus in Shandong Province from 2013 to 2014.
In this study, a total of 385 samples were collected from Shandong pig farms during 2013 and 2014, when pigs were not inoculated with any vaccine. Results indicated that, out of 385 samples, 47 (12.21%) were PRRSV-RNA-positive. The gene sequence analysis of 12 ORF5, 12 ORF7, and 8 Nsp2 of these samples was used to determine the molecular epidemiology of PRRSV in different parts of China's Shandong Province. The phylogenetic tree based on these 3 genes indicated that the Chinese PRRSV strains could be divided into five subgroups and two large groups. The 8 study strains were clustered into subgroup IV, another 4 strains int...
Source: Infection, Genetics and Evolution - May 7, 2015 Category: Genetics & Stem Cells Authors: Wang FX, Qin LT, Liu Y, Liu X, Sun N, Yang Y, Chen T, Zhu HW, Ren JQ, Sun YJ, Cheng SP, Wen YJ Tags: Infect Genet Evol Source Type: research

Caffeic acid Attenuates rat liver reperfusion injury through Sirt3-dependent regulation of mitochondrial respiratory chain.
This study investigated the effect of CA on liver I/R injury, microcirculatory disturbance and potential mechanism, particularly focusing on Sirt3 dependent MRC. The liver I/R of male Sprague-Dawley rats was established by occlusion of portal area vessels for 30min followed by 120min reperfusion. CA (15mg/kg/h) was continuously infused via femoral vein staring from 30min before ischemia. After I/R, Sirt3 expression and MRC activity decreased, acetylation of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 and succinate dehydrogenase complex, subunit A, flavoprotein variant were provoked, and the liver microcirc...
Source: Free Radical Biology and Medicine - May 7, 2015 Category: Biology Authors: Mu HN, Li Q, Pan CS, Liu YY, Yan L, Hu BH, Sun K, Chang X, Zhao XR, Fan JY, Han JY Tags: Free Radic Biol Med Source Type: research

Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers.
Abstract We aimed to investigate mitochondrial function and biogenesis and autophagy in the brain of type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and homogenates from cerebral cortex and hippocampus of wild-type (WT), triple transgenic AD (3xTg-AD) and T2D mice were used to evaluate mitochondrial functional parameters and protein levels of mitochondrial biogenesis, autophagy and synaptic integrity markers, respectively. A significant decrease in mitochondrial respiration, membrane potential and energy levels was observed in T2D and 3xTg-AD mice. Also, a significant decrease i...
Source: Biochimica et Biophysica Acta - May 7, 2015 Category: Biochemistry Authors: Carvalho C, Santos MS, Oliveira CR, Moreira PI Tags: Biochim Biophys Acta Source Type: research

Association between peripheral airway function and neutrophilic inflammation in asthma
ConclusionsAcinar and conductive airway dysfunction is associated with different inflammatory profiles in asthmatic airways, independently of the effects of age and disease duration. The association between acinar airway dysfunction and neutrophilic airway inflammation may have implications for asthma treatment. (Source: Respirology)
Source: Respirology - May 7, 2015 Category: Respiratory Medicine Authors: Claude S. Farah, Laurien A.B. Keulers, Kate M. Hardaker, Matthew J. Peters, Norbert Berend, Dirkje S. Postma, Cheryl M. Salome, Gregory G. King Tags: Original Article Source Type: research

Predictors of intensive care unit transfer or death in emergency department patients with suspected infection
Conclusion: Readily available clinical and laboratory variables at arrival in the ED can support identification of late deterioration leading to ICU transfer or death within 48 h of admission. (Source: European Journal of Emergency Medicine)
Source: European Journal of Emergency Medicine - May 6, 2015 Category: Emergency Medicine Tags: Original Articles Source Type: research

A systematic review of hepatic tuberculosis with considerations in human immunodeficiency virus co-infection
Conclusions: Clinicians in TB-endemic regions should maintain a high index of suspicion for hepatic TB in patients presenting with hepatomegaly, fever, respiratory symptoms, and elevated liver enzymes. The most sensitive imaging modality is a CT scan, while the most specific diagnostic modality is a liver biopsy with nucleic acid testing of liver tissue samples. Upon diagnosis, 4-drug anti-TB therapy should promptly be initiated. HIV co-infected patients may have more complex cases and should be closely monitored for complications. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 6, 2015 Category: Infectious Diseases Authors: Andrew HickeyLilishia GounderMahomed-Yunus MoosaPaul Drain Source Type: research

Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression
Conclusions: Our data indicate that RelB attenuates COX-2 expression in lung structural cells, such that loss of pulmonary RelB may be an important determinant in the aberrant, heightened inflammation associated with COPD pathogenesis. (Source: Respiratory Research)
Source: Respiratory Research - May 6, 2015 Category: Respiratory Medicine Authors: Jared SheridanMichela ZagoParameswaran NairPei LiJean BourbeauWan TanQutayba HamidDavid EidelmanAndrea BenedettiCarolyn Baglole Source Type: research

Bronchial fibroepithelial polyp: a clinico‐radiologic, bronchoscopic, histopathological and in‐situ hybridisation study of 15 cases of a poorly recognised lesion
ConclusionDespite the benign behaviour of bronchial fibroepithelial polyps, it is important to fix some robust diagnostic criteria in order to avoid misdiagnoses leading to unnecessary aggressive treatment. Differential diagnosis mainly includes inflammatory polyps, hamartomas and papillomas. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 6, 2015 Category: Respiratory Medicine Authors: Eleonora Casalini, Alberto Cavazza, Alessandro Andreani, Alessandro Marchioni, Gloria Montanari, Francesca Gaia Cappiello, Maria Cecilia Mengoli, Paolo Corradini, Lorenzo Agostini, Roberto Serini, Giulio Rossi Tags: Original Article Source Type: research

γ-Tocotrienol reduces human airway smooth muscle cell proliferation and migration
Publication date: Available online 5 May 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Tomoya Harada , Akira Yamasaki , Hiroki Chikumi , Kiyoshi Hashimoto , Ryota Okazaki , Miki Takata , Takehito Fukushima , Masanari Watanabe , Jun Kurai , Andrew J. Halayko , Eiji Shimizu Aims Vitamin E is an antioxidant that occurs in 8 different forms (α, β, γ, and δ tocopherol and tocotrienol). Clinical trials of tocopherol supplementation to assess the impact of antioxidant activity in asthma have yielded equivocal results. Tocotrienol exhibits greater antioxidant activity than tocopherol in several biologi...
Source: Pulmonary Pharmacology and Therapeutics - May 6, 2015 Category: Respiratory Medicine Source Type: research

The Risk and Outcomes of Pneumonia in Patients on Inhaled Corticosteroids
Publication date: Available online 5 May 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Oriol Sibila , Natalia Soto-Gomez , Marcos I. Restrepo Corticosteroids are frequently prescribed anti-inflammatory medications. Inhaled corticosteroids (ICS) are indicated for Chronic Obstructive Pulmonary Disease (COPD) and asthma. ICSs are associated with a decrease in exacerbations and improved quality of life in COPD, however multiple studies have linked the chronic use of ICSs with an increased risk of developing pneumonia, though the effect on mortality is unclear. We review the association of ICS with the ...
Source: Pulmonary Pharmacology and Therapeutics - May 6, 2015 Category: Respiratory Medicine Source Type: research

The 24-h lung-function profile of once-daily tiotropium and olodaterol fixed-dose combination in chronic obstructive pulmonary disease
Conclusions Overall, this study demonstrated improvements in lung function over 24 h with an FDC of tiotropium + olodaterol over tiotropium or olodaterol alone, with no observed difference in tolerability. number NCT01559116. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 6, 2015 Category: Respiratory Medicine Source Type: research

Crossover and maximal fat oxidation points during running and cycling in sedentary subjects
Conclusion Our data show that COP and LIPOXmax measured during submaximal exercise (based on measured MAP or MAV) were not affected by the choice of ergometer. Both CE and TM yielded accurate and quiet similar metabolic indices that could be used to individualize training in healthy sedentary adults. (Source: Science and Sports)
Source: Science and Sports - May 6, 2015 Category: Sports Medicine Source Type: research

Icatibant in Angiotensin Converting Enzyme (ACE) Inhibitor‐Associated Angioedema
DiscussionAll patients improved after receiving icatibant, consistent with its bradykinin‐receptor blocking mechanism. Icatibant rapidly reversed symptoms, and appeared to avert the need for intubation or expedite extubation. Timely use of icatibant in ACE‐inhibitor associated angioedema may avert the need for invasive airway procedures and intensive care unit (ICU) admission. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - May 6, 2015 Category: Internal Medicine Authors: Jie Shen Fok, Constance H Katelaris, Anthony F Brown, William B Smith Tags: Original Article Source Type: research

How we managed a difficult to ventilate patient
Sunil Kumar GargIndian Journal of Critical Care Medicine 2015 19(5):278-279A 40-year-old female presented with respiratory difficulty, cough and sputum with blood streaking. Her right lung was destroyed, and trachea was shifted to the same side. On mechanical ventilation, she developed hypoxia and rise in blood pressure. Ventilator was not delivering set tidal volume. After looking into the cause, it was decided to reintubate the patient with new endotracheal tube after cutting bevel. Thereafter, there was successful ventilation. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - May 6, 2015 Category: Intensive Care Authors: Sunil Kumar Garg Source Type: research

Acute concentrated phenol dermal burns: Complications and management
Tapan Jayantilal ParikhIndian Journal of Critical Care Medicine 2015 19(5):280-282Phenol burns can result in multiple organ failure. This is a case report of acute severe phenol dermal burn after accidental splash of 94% phenol on 35-year-old patient's body who was brought to hospital after 90 min of exposure. Decontamination was done with high-density water and glycerol. Early complications in form of metabolic acidosis and acute renal failure required hemodialysis. Extensive protein denaturation was managed with IV albumin and high protein diet. Patient also developed pleural effusion and acute respiratory ...
Source: Indian Journal of Critical Care Medicine - May 6, 2015 Category: Intensive Care Authors: Tapan Jayantilal Parikh Source Type: research

Extra corporeal carbon dioxide removal: A reliable modality in refractory hypercapnia to prevent invasive ventilation
Atiharsh Mohan Agarwal, Tapas Kumar SinghIndian Journal of Critical Care Medicine 2015 19(5):286-288Extracorporeal carbon dioxide removal (ECCO2R) is a valid alternative to consider in hypercapnic respiratory failure in chronic obstructive pulmonary disease (COPD) patients to avoid invasive ventilation when noninvasive ventilation fails. Here we report a similar case, after obtaining informed consent, where a patient suffering from severe hypercapnic respiratory failure due to COPD, was selected for ECCO2R and improved remarkably. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - May 6, 2015 Category: Intensive Care Authors: Atiharsh Mohan AgarwalTapas Kumar Singh Source Type: research

Assessment of immunotoxicity of dibutyl phthalate using live zebrafish embryos
This study set out to understand the immune-toxic effects of dibutyl phthalate (DBP) using transgenic, albino or AB line zebrafish. Zebrafish embryos were exposed to different concentrations of DBP, and the immune cells formation, phagocytosis ability were measured after a short-term exposure to DBP for 6 h post-fertilization (hpf) to 72 or 96 hpf. Exposure to DBP was found to inhibit the neutrophils and macrophage formation in a concentration-dependent manner. The ability of macrophage phagocytosis was all decreased after exposure to DBP, indicating the occurrence of immunotoxicity. The respiratory burst was induced, and ...
Source: Fish and Shellfish Immunology - May 6, 2015 Category: Biology Source Type: research

Effects of fenugreek (Trigonella foenum graecum) on gilthead seabream (Sparus aurata L.) Immune status and growth performance
Publication date: Available online 5 May 2015 Source:Fish & Shellfish Immunology Author(s): Elham Awad , Rebeca Cerezuela , M.Ángeles Esteban The possible effect of dietary administration of fenugreek (Trigonella foenum graecum) on gilthead seabream (Sparus aurata L.) immune status and growth performance was studied. Fish were divided into 4 groups before being fed with commercial diet supplemented with 0% (control), 1%, 5% and 10% of fenugreek seeds for 4 weeks. The effects of the diets were analysed on the cellular (respiratory burst activity and leucocyte peroxidase content) and humoral (complement activity, ...
Source: Fish and Shellfish Immunology - May 6, 2015 Category: Biology Source Type: research

Performance evaluation of Puritan® universal transport system (UniTranz‐RT™) for preservation and transport of clinical viruses
The ability of a non‐propagating microbial transport medium to maintain the viability of clinically relevant viruses was compared to a similar commercial medium to establish performance equivalence. Two dilutions of stock of test viruses, namely adenovirus (AdV), cytomegalovirus (CMV), echovirus Type 30 (EV), herpes simplex virus (HSV) types 1 and 2, influenza A, parainfluenza 3 (PIV), respiratory syncytial virus (RSV), and varicella zoster virus (VZV), were spiked into Puritan® Medical Products Company Universal Transport System (UniTranz‐RT™) and BDTM Universal Viral Transport System (UVT) and incubated at 4 °C...
Source: Journal of Medical Virology - May 6, 2015 Category: Virology Authors: Trevor Brasel, Kunapuli T. Madhusudhan, Krystle Agans, Karen Dearen, Sara L. Jones, Robert L. Sherwood Tags: Research Article Source Type: research

Transcriptional activation of LON Gene by a new form of mitochondrial stress: A role for the nuclear respiratory factor 2 in StAR overload response (SOR)
Publication date: 15 June 2015 Source:Molecular and Cellular Endocrinology, Volume 408 Author(s): Assaf Bahat , Shira Perlberg , Naomi Melamed-Book , Sara Isaac , Amir Eden , Ines Lauria , Thomas Langer , Joseph Orly High output of steroid hormone synthesis in steroidogenic cells of the adrenal cortex and the gonads requires the expression of the steroidogenic acute regulatory protein (StAR) that facilitates cholesterol mobilization to the mitochondrial inner membrane where the CYP11A1/P450scc enzyme complex converts the sterol to the first steroid. Earlier studies have shown that StAR is active while pausing on the cyto...
Source: Molecular and Cellular Endocrinology - May 6, 2015 Category: Endocrinology Source Type: research

Resveratrol ameliorates abnormalities of fluid and electrolyte secretion in a hypoxia‐Induced model of acquired CFTR deficiency
ConclusionsCFTR activation with a leading edge Cl− secretagogue such as resveratrol represents an innovative approach to overcoming acquired CFTR defects in sinus and nasal airway disease. This exciting new strategy bears further testing in non‐CF individuals with chronic rhinosinusitis. Level of EvidenceN/A. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - May 6, 2015 Category: ENT & OMF Authors: Bradford A. Woodworth Tags: Allergy/Rhinology Source Type: research

Infection in home health care: Results from national Outcome and Assessment Information Set data
Conclusion To our knowledge, this is the first study to examine the proportion of hospitalizations or emergency care treatment caused by infection in HHC and the agency-level infection rate at a national level by using OASIS data. These data demonstrate that infection is a serious problem in HHC, and infection rates varied between agencies. The variance in agency level rates may be caused by differences in infection control policies and practices. Better infection surveillance system in HHC is needed to benchmark quality of care. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - May 6, 2015 Category: Infectious Diseases Source Type: research

The contribution of hypoxia to the association between sleep apnoea, insomnia, and cardiovascular mortality in community-dwelling elderly with and without cardiovascular disease
Conclusion: In the elderly with CVD, SDB mediated by hypoxia can be associated with more insomnia and a worse prognosis. (Source: European Journal of Cardiovascular Nursing)
Source: European Journal of Cardiovascular Nursing - May 6, 2015 Category: Nursing Authors: Johansson, P., Svensson, E., Alehagen, U., Jaarsma, T., Brostrom, A. Tags: Original Articles Source Type: research

Medical problems in obstetrics: Inherited Metabolic Disease
Publication date: Available online 21 April 2015 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Elaine Murphy An increasing number of women with rare inherited disorders of metabolism are becoming pregnant. Whilst, in general, outcomes for women and their children are good, there are a number of issues that need to be considered. Currently, limited specific guidance on the management of these conditions in pregnancy is available. Prepregnancy counselling with information on inheritance, options for reproduction, teratogenicity risk, potential impact on maternal health and lon...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - May 6, 2015 Category: OBGYN Source Type: research

Respiratory disease in pregnancy
This article focuses on several important respiratory issues in pregnancy. The management of asthma, one of the most common chronic illnesses in pregnancy, remains largely unchanged compared to the nonpregnant state. Infectious respiratory illness, including pneumonia and tuberculosis, are similarly managed in pregnancy with antibiotics, although special attention may be needed for antibiotic choices with more pregnancy safety data. When mechanical ventilation is necessary, consideration should be given to the maternal hemodynamics of pregnancy and fetal oxygenation. Maintaining maternal oxygen saturation above 95% is reco...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - May 6, 2015 Category: OBGYN Source Type: research

Microvascular free tissue transfer in acute and secondary burn reconstruction
The mainstay of operative treatment in burns is split skin grafting with free tissue transfer being indicated in a minority of cases. However, free tissue transfer faces a number of challenges in the burns patient. These include; overall cardiovascular and respiratory stability of the patient, availability of suitable vessels for anastomosis, sufficient debridement of devitalized tissue and a potentially increased risk of infection. We carried out a retrospective study in order to determine the indications, timing, principles of flap selection, complications, outcomes and methods of promoting flap survival when free tissue...
Source: Injury - May 6, 2015 Category: Orthopaedics Authors: Shehab Jabir, Quentin Frew, Ashish Magdum, Naguib El-Muttardi, Bruce Philp, Peter Dziewulski Source Type: research

Mask versus Nasal Tube for Stabilization of Preterm Infants at Birth: Respiratory Function Measurements
To compare the nasal tube with face mask as interfaces for stabilization of very preterm infants at birth by using physiological measurements of leak, obstruction, and expired tidal volumes during positive pressure ventilation (PPV). (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - May 6, 2015 Category: Pediatrics Authors: Jeroen J. van Vonderen, C. Omar Kamlin, Jennifer A. Dawson, Frans J. Walther, Peter G. Davis, Arjan B. te Pas Tags: Original Article Source Type: research

High temporal resolution dynamic MRI and arterial input function for assessment of GFR in pediatric subjects
ConclusionThe HTR‐AIF method improves the accuracy of both the AIF and GFR estimates derived from the respiratory‐gated acquisitions, and makes GFR estimation feasible in free‐breathing pediatric subjects. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 6, 2015 Category: Radiology Authors: Umit Yoruk, Manojkumar Saranathan, Andreas M. Loening, Brian A. Hargreaves, Shreyas S. Vasanawala Tags: Full Paper Source Type: research

Prescribing of long-acting beta-2-agonists/inhaled corticosteroids after the SMART trial
Conclusions: Between 2004 and 2008, we found a moderate increase in guideline-adherent LABA prescribing in a representative German population. Elderly men received a significant number of LABA prescriptions without concomitant ICS probably due to ACOS. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 6, 2015 Category: Respiratory Medicine Authors: Marietta RottenkolberRainald FischerLuisa IbáñezJoan FortunyRobert ReynoldsJustyna AmelioRoman GerlachMartin TauscherPetra ThürmannJoerg HasfordSven Schmiedl Source Type: research