Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Circulating miRNAs as Potential Biomarkers of Endothelial Dysfunction In Obese Children.
Conclusion: Plasma miRNAs may be useful as potential screening tools for the presence of ED in children, and may reveal ED-relevant target genes. PMID: 26270249 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 13, 2015 Category: Respiratory Medicine Authors: Khalyfa A, Kheirandish-Gozal L, Bhattacharjee R, Khalyfa AA, Gozal D Tags: Chest Source Type: research

Transcriptional profiling of endobronchial ultrasound guided lymph node samples aids diagnosis of mediastinal lymphadenopathy.
Conclusions: Machine learning analysis of transcriptional profiling in mediastinal lymphadenopathy may significantly improve the clinical utility of EBUS guided biopsies. PMID: 26270185 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 13, 2015 Category: Respiratory Medicine Authors: Tomlinson GS, Thomas N, Chain BM, Best K, Simpson N, Hardavella G, Brown J, Bhowmik A, Navani N, Janes SM, Miller RF, Noursadeghi M Tags: Chest Source Type: research

The Association Between Indwelling Arterial Catheters and Mortality in Hemodynamically Stable Patients With Respiratory Failure: A Propensity Score Analysis.
Conclusions: In hemodynamically stable mechanically ventilated patients, the presence of an IAC is not associated with a difference in 28-day mortality. Validation in other datasets, as well as further analyses in other subgroups is warranted. PMID: 26270005 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - August 13, 2015 Category: Respiratory Medicine Authors: Hsu DJ, Feng M, Kothari R, Zhou H, Chen KP, Celi LA Tags: Chest Source Type: research

A Distress Protocol for Respiratory Emergencies in Terminally Ill Patients With Lung Cancer or Chronic Obstructive Pulmonary Disease.
Abstract A combination of opioid, midazolam, and scopolamine (that we call "distress protocol" [DP]) is used to induce transient sedation when emergencies occur in palliative care. We wished to describe the prescription and administration of DP in terminally ill patients with either lung cancer or chronic obstructive pulmonary disease (COPD). In a retrospective study, 96 of 100 patients with cancer and 85 of 100 patients with COPD had a DP prescribed. Thirty patients with cancer and 29 with COPD received at least 1 DP. All patients receiving a DP for an appropriate indication were sedated within 30 minutes. There w...
Source: The American Journal of Hospice and Palliative Care - August 13, 2015 Category: Palliative Care Authors: Godbout K, Tremblay L, Lacasse Y Tags: Am J Hosp Palliat Care Source Type: research

Leucobacter musarum subsp. musarum sp. nov., subsp. nov.; Leucobacter musarum subsp. japonicus subsp. nov., and Leucobacter celer subsp. astrifaciens subsp. nov., three novel nematopathogenic bacteria isolated from Caenorhabditis, with an emended description of Leucobacter celer.
Abstract Three Gram-stain positive, irregular rod-shaped, non-motile, non-spore-forming bacteria were isolated from nematodes collected from Santa Antao, Cabo Verde (CBX151T, CBX152T) and Kakegawa, Japan (CBX130T). Based on 16S rRNA gene sequence similarity, CBX130T, CBX151T and CBX152T were shown to belong to the genus Leucobacter. This affiliation was supported by chemotaxonomic data (2,4-diaminobutyric acid in the cell wall; major respiratory quinones MK-10 and MK-11; major polar lipids phosphatidylglycerol and diphosphatidylglycerol; major fatty acids anteiso-C15:0, anteiso-C17:0 and iso-C16:0.) CBX130T and CBX...
Source: International Journal of Systematic and Evolutionary Microbiology - August 13, 2015 Category: Microbiology Authors: Clark LC, Hodgkin J Tags: Int J Syst Evol Microbiol Source Type: research

Interaction Effects of Acute Kidney Injury, Acute Respiratory Failure, and Sepsis on 30-Day Postoperative Mortality in Patients Undergoing -High-Risk Intraabdominal General Surgical Procedures.
CONCLUSIONS: In high-risk general surgery patients, the development of AKI, acute respiratory failure, or sepsis is independently associated with an increase in 30-day mortality. In addition, the development of 2 complications shows significant positive additive interactions to further increase the risk of mortality. Our findings suggest that interactions between these 3 perioperative complications increase the risk of mortality more than would be expected by the independent effects of each complication alone. PMID: 26273749 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - August 13, 2015 Category: Anesthesiology Authors: Kim M, Brady JE, Li G Tags: Anesth Analg Source Type: research

CUR-65 Score for Community-Acquired Pneumonia Predicted Mortality Better Than CURB-65 Score in Low-Mortality Rate Settings.
CONCLUSIONS: CURB-65 score could be simplified by removing low blood pressure to orchestrate an improvement in predicting mortality in CAP patients who have a low risk of death. A CUR-65 score of ≥2 might be a more valuable cutoff value for severe CAP. PMID: 26280118 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - August 13, 2015 Category: Journals (General) Authors: Li HY, Guo Q, Song WD, Zhou YP, Li M, Chen XK, Liu H, Peng HL, Yu HQ, Chen X, Liu N, Lü ZD, Liang LH, Zhao QZ, Jiang M Tags: Am J Med Sci Source Type: research

Effect of MLC tracking latency on conformal volumetric modulated arc therapy (VMAT) plans in 4D stereotactic lung treatment.
CONCLUSIONS: Assuming that internal motion can be modelled by a rigid translation of the patient, MLC tracking of conformal VMAT can be effectively accomplished in the absence of an internal target margin for substantial breathing motion (4s period and 20mm peak-peak amplitude) so long as the system latency is less than 150ms. PMID: 26277856 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - August 13, 2015 Category: Radiology Authors: Bedford JL, Fast MF, Nill S, McDonald FM, Ahmed M, Hansen VN, Oelfke U Tags: Radiother Oncol Source Type: research

Comparison of the AdvanSure™ real-time RT-PCR and Seeplex(®) RV12 ACE assay for the detection of respiratory viruses.
In conclusion, the AdvanSure assay demonstrated comparable performance to the Seeplex assay. PMID: 26277911 [PubMed - as supplied by publisher] (Source: Journal of Virological Methods)
Source: Journal of Virological Methods - August 13, 2015 Category: Virology Authors: Jung YJ, Kwon HJ, Huh HJ, Ki CS, Lee NY Tags: J Virol Methods Source Type: research

Regulation of Lactobacillus plantarum contamination on the carbohydrate and energy related metabolisms of Saccharomyces cerevisiae during bioethanol fermentation.
In this study, Lactobacillus plantarum ATCC 8014 was co-cultivated with S. cerevisiae S288C to mimic the L. plantarum contamination in industrial bioethanol fermentation. The contaminative L. plantarum-associated expression changes of genes involved in carbohydrate and energy related metabolisms in S. cerevisiae cells were determined by quantitative real-time polymerase chain reaction to evaluate the influence of L. plantarum on carbon source utilization and energy related metabolism in yeast cells during bioethanol fermentation. Contaminative L. plantarum influenced the expression of most of genes which are responsible fo...
Source: The International Journal of Biochemistry and Cell Biology - August 13, 2015 Category: Biochemistry Authors: Dong SJ, Lin XH, Li H Tags: Int J Biochem Cell Biol Source Type: research

Medication Administration in Critical Care Transport of Adult Patients with Hypoxemic Respiratory Failure
Brief Report Susan R. Wilcox, Mark S. Saia, Heather Waden, Susan J. McGahn, Michael Frakes, Suzanne K. Wedel, Jeremy B. Richards, Prehospital and Disaster Medicine, Volume 30 Issue 04, pp 431-435Abstract (Source: Prehospital and Disaster Medicine)
Source: Prehospital and Disaster Medicine - August 12, 2015 Category: Emergency Medicine Source Type: research

Atypical acute respiratory disorder in late preterm and term newborn infants
The Journal of Maternal-Fetal & Neonatal Medicine, Ahead of Print. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - August 12, 2015 Category: Perinatology & Neonatology Tags: article Source Type: research

Is there still a role for high-frequency oscillatory ventilation in neonates, children and adults?
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - August 12, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Assessment of Population Exposure to Coarse and Fine Particulate Matter in the Urban Areas of Chennai, India.
Authors: Prasannavenkatesh R, Andimuthu R, Kandasamy P, Rajadurai G, Subash Kumar D, Radhapriya P, Ponnusamy M Abstract Research outcomes from the epidemiological studies have found that the course (PM10) and the fine particulate matter (PM2.5) are mainly responsible for various respiratory health effects for humans. The population-weighted exposure assessment is used as a vital decision-making tool to analyze the vulnerable areas where the population is exposed to critical concentrations of pollutants. Systemic sampling was carried out at strategic locations of Chennai to estimate the various concentration levels ...
Source: The Scientific World Journal - August 12, 2015 Category: Science Tags: ScientificWorldJournal Source Type: research

Efficacy and Safety of Diagnostic Thoracoscopy in Undiagnosed Pleural Effusions
Conclusions: MT is an effective and safe procedure for diagnosing pleural effusions of undetermined causes. In areas with high tuberculosis prevalence, MT should be particularly helpful in the differential diagnosis of tuberculous pleural effusion.Respiration (Source: Respiration)
Source: Respiration - August 12, 2015 Category: Respiratory Medicine Source Type: research

The Difference in Maximum Standardized Uptake Value among Lung Adenocarcinomas Located at the Upper and Lower Zone on PET/CT
Conclusions: maxSUV of a tumor in the LZ group is apparently lower than the value which reflects the potential malignancy of a tumor. We have to carefully consider these facts when selecting the appropriate surgical procedure for lung cancer with PET/CT and HRCT.Respiration (Source: Respiration)
Source: Respiration - August 12, 2015 Category: Respiratory Medicine Source Type: research

Serum high-sensitivity C-reactive protein in patients with obstructive sleep apnea with special reference to metabolic syndrome
(Source: Sleep and Breathing)
Source: Sleep and Breathing - August 12, 2015 Category: Respiratory Medicine Source Type: research

Comparison of a simple obstructive sleep apnea screening device with standard in-laboratory polysomnography
Conclusion The AS has a high sensitivity for detection of OSA with AHI ≥ 15, but only modest specificity. The AS could be a useful component of an OSA screening program; however, negative results should be interpreted cautiously. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 12, 2015 Category: Respiratory Medicine Source Type: research

A pathway underlying the impact of CPAP adherence on intimate relationship with bed partner in men with obstructive sleep apnea
Conclusions CPAP therapy with good adherence is related directly and indirectly to a better intimate relationship with bed partner in men with OSA. It was possibly attributed to reduced daytime sleepiness and increased activity level. (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 12, 2015 Category: Respiratory Medicine Source Type: research

Use of ADO II device in a large aorto-pulmonary collateral-an interesting case
Publication date: Available online 6 August 2015 Source:Indian Heart Journal Author(s): N. Awasthy, R. Garg, P. Khurana, S. Radhakrishnan A 11month old girl was diagnosed to have a large aorto pulmonary collateral during evaluation for respiratory distress and seizures. Echocardiographic evaluation showed a large collateral from the descending aorta to left lung with ventricular dysfunction (left ventricular ejection fraction of 40%). This was confirmed on computed tomography angiogram (CT) scan. The collateral was closed with Amplatzer Ductal Occluder II device under fluoroscopic guidance. To the best of our knowled...
Source: Indian Heart Journal - August 12, 2015 Category: Cardiology Source Type: research

Evaluating acellular versus cellular perfusate composition during prolonged ex vivo lung perfusion after initial cold ischemia for 24 hours
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - August 12, 2015 Category: Transplant Surgery Authors: Simon Becker, Jasmin Steinmeyer, Murat Avsar, Klaus Höffler, Jawad Salman, Axel Haverich, Gregor Warnecke, Matthias Ochs, Anke Schnapper Tags: Original Article Source Type: research

Analysis of TTSuV1b antibody in porcine serum and its correlation with four antibodies against common viral infectious diseases
Conclusion: In conclusion, examination of anti-TTSuV1b antibody in porcine serum with the presently established ELISA method would serve as a supplementary approach for etiological investigation, and the combined statistical analysis of the antibodies against four other viruses might help to further understand the TTSuV1b infection as well as its pathogenicity. (Source: Virology Journal)
Source: Virology Journal - August 12, 2015 Category: Virology Authors: Zhongsheng LiJingxin QiaoYonglong HeYiwen ChenGuiping Wang Source Type: research

Identification of the mitochondrially encoded subunit 6 of F1FO ATPase in Trypanosoma brucei
Publication date: Available online 11 August 2015 Source:Molecular and Biochemical Parasitology Author(s): Ingrid Škodová-Sveráková, Anton Horváth, Dmitri A. Maslov Kinetoplast maxicircle DNA of trypanosomatids encodes eighteen proteins. RNA editing is required to confer translatability to mRNA for twelve of these. Sequence conservation of the predicted hydrophobic polypeptides indicates that they represent functional components of the respiratory chain. Yet, so far only two of those, cytochrome c oxidase subunit I and apocytochrome b of cytochrome c reductase, have been identified with biochemical methods. Here ...
Source: Molecular and Biochemical Parasitology - August 12, 2015 Category: Parasitology Source Type: research

Copy number variants associated with epilepsy from gene expression microarrays
Publication date: Available online 11 August 2015 Source:Journal of Clinical Neuroscience Author(s): Dong Wang, Xia Li, Shanshan Jia, Yan Wang, Zhijing Wang, Xixiao Song, Liang Liu We aimed to identify novel copy number variations (CNV) that might contribute to the pathogenesis of epilepsy. Epilepsy is a common brain disorder characterized by recurring seizures and various serious comorbidities, including respiratory, cardiovascular, and neurologic dysfunction. CNV have recently been considered as important risk factors for epilepsy. With public gene expression data from brain tissue of 23 epilepsy patients and 23...
Source: Journal of Clinical Neuroscience - August 12, 2015 Category: Neuroscience Source Type: research

Increased incidence of intermittent hypoxemia in the Ts65Dn mouse model of Down syndrome
Publication date: 14 September 2015 Source:Neuroscience Letters, Volume 604 Author(s): Devsmita Das, Brian Medina, Mehmet Akif Baktir, Fatemeh S. Mojabi, Atoossa Fahimi, Ravikumar Ponnusamy, Ahmad Salehi In addition to nervous system, cardiovascular and respiratory systems are primarily affected in Down syndrome (DS). The Ts65Dn mouse model is widely used to recapitulate cognitive dysfunction in DS. While these mice consistently show failure in learning and memory along with functional and structural abnormalities in the hippocampal region, the underlying mechanisms behind cognitive dysfunction remain to be fully ...
Source: Neuroscience Letters - August 12, 2015 Category: Neuroscience Source Type: research

Respiratory optimisation and mobile ECMO for severe respiratory failure
(Source: Anaesthesia)
Source: Anaesthesia - August 12, 2015 Category: Anesthesiology Authors: A. Jones Tags: Correspondence Source Type: research

Hydrogen sulfide inhalation ameliorates allergen induced airway hypereactivity by modulating mast cell activation
In conclusion, inhaled hydrogen sulfide improves lung function and inhibits bronchial hyper-reactivity by modulating mast cells and in turn fibroblast activation. Graphical abstract (Source: Pharmacological Research)
Source: Pharmacological Research - August 12, 2015 Category: Drugs & Pharmacology Source Type: research

Alloimmunization due to red cell antibodies in Rhesus positive Omani Pregnant Women: Maternal and Perinatal outcome
Conclusion: Alloimmunization with anti-E, anti-c, and anti-kell were the most common antibodies among the study group. Minor RBCs alloimmunization was an important cause of neonatal morbidity. (Source: Asian Journal of Transfusion Science)
Source: Asian Journal of Transfusion Science - August 12, 2015 Category: Hematology Authors: Tamima Al-DughaishiIkhlass S Al-RubkhiMaymoona Al-DuhliYusra Al-HarrasiVaidyanathan Gowri Source Type: research

Causes of hospital admission among people living with HIV worldwide: a systematic review and meta-analysis
Publication date: Available online 11 August 2015 Source:The Lancet HIV Author(s): Nathan Ford, Zara Shubber, Graeme Meintjes, Beatriz Grinsztejn, Serge Eholie, Edward J Mills, Mary-Ann Davies, Marco Vitoria, Martina Penazzato, Sabin Nsanzimana, Lisa Frigati, Daniel O'Brien, Tom Ellman, Olawale Ajose, Alexandra Calmy, Meg Doherty Background Morbidity associated with HIV infection is poorly characterised, so we aimed to investigate the contribution of different comorbidities to hospital admission and in-hospital mortality in adults and children living with HIV worldwide. Methods Using a broad search strat...
Source: The Lancet HIV - August 12, 2015 Category: Infectious Diseases Source Type: research

Distinct Contributions of Neutrophils and CCR2+ Monocytes to Pulmonary Clearance of Different Klebsiella pneumoniae Strains [Bacterial Infections]
Klebsiella pneumoniae is a common respiratory pathogen, with some strains having developed broad resistance to clinically available antibiotics. Humans can become infected with many different K. pneumoniae strains that vary in genetic background, antibiotic susceptibility, capsule composition, and mucoid phenotype. Genome comparisons have revealed differences between K. pneumoniae strains, but the impact of genomic variability on immune-mediated clearance of pneumonia remains unclear. Experimental studies of pneumonia in mice have used the rodent-adapted 43816 strain of K. pneumoniae and demonstrated that neutrophils are e...
Source: Infection and Immunity - August 12, 2015 Category: Infectious Diseases Authors: Xiong, H., Carter, R. A., Leiner, I. M., Tang, Y.-W., Chen, L., Kreiswirth, B. N., Pamer, E. G. Tags: Bacterial Infections Source Type: research

Moraxella catarrhalis Binds Plasminogen To Evade Host Innate Immunity [Molecular Pathogenesis]
In this study, we found that a series of clinical isolates (n = 58) of the respiratory pathogen Moraxella catarrhalis, which is commonly isolated from preschool children and adults with chronic obstructive pulmonary disease (COPD), significantly binds human plasminogen. Ubiquitous surface protein A2 (UspA2) and hybrid UspA2 (UspA2H) were identified as the plasminogen-binding factors in the outer membrane proteome of Moraxella. Furthermore, expression of a series of truncated recombinant UspA2 and UspA2H proteins followed by a detailed analysis of protein-protein interactions suggested that the N-terminal head domains bound...
Source: Infection and Immunity - August 12, 2015 Category: Infectious Diseases Authors: Singh, B., Al-Jubair, T., Voraganti, C., Andersson, T., Mukherjee, O., Su, Y.-C., Zipfel, P., Riesbeck, K. Tags: Molecular Pathogenesis Source Type: research

ArcA Controls Metabolism, Chemotaxis, and Motility Contributing to the Pathogenicity of Avian Pathogenic Escherichia coli [Molecular Pathogenesis]
In this study, we showed that ArcA (aerobic respiratory control), a global regulator important for E. coli's adaptation from anaerobic to aerobic conditions and control of that bacterium's enzymatic defenses against reactive oxygen species (ROS), is involved in the virulence of APEC. Deletion of arcA significantly attenuates the virulence of APEC in the duck model. Transcriptome sequencing (RNA-Seq) analyses comparing the APEC wild type and the arcA mutant indicate that ArcA regulates the expression of 129 genes, including genes involved in citrate transport and metabolism, flagellum synthesis, and chemotaxis. Further inve...
Source: Infection and Immunity - August 12, 2015 Category: Infectious Diseases Authors: Jiang, F., An, C., Bao, Y., Zhao, X., Jernigan, R. L., Lithio, A., Nettleton, D., Li, L., Wurtele, E. S., Nolan, L. K., Lu, C., Li, G. Tags: Molecular Pathogenesis Source Type: research

Area-level socioeconomic context, total mortality and cause-specific mortality in Spain: Heterogeneous findings depending on the level of geographic aggregation
The objective of this study was to estimate the association between area-level socioeconomic context and mortality in Spain, using two different geographic aggregations. Nation-wide prospective study covering all persons living in Spain in 2001. Mortality was analysed in Spanish citizens by province of residence and in citizens of Madrid by neighbourhood of residence. Provinces and neighbourhoods were grouped into quartiles according to two socioeconomic indicators: percentage of the population with university education and unemployment rate. The measure of association was the rate ratio for total mortality and cause-speci...
Source: Social Science and Medicine - August 12, 2015 Category: Psychiatry & Psychology Source Type: research

2015 ATS conference sleep talks overshadowed by the discussion about ASV negative outcome in heart failure: sleep medicine highlights from the 2015 ATS annual conference in Denver
(Source: Sleep and Breathing)
Source: Sleep and Breathing - August 12, 2015 Category: Respiratory Medicine Source Type: research

Which field walking test should be used to assess functional exercise capacity in lung cancer? an observational study
Conclusions: The ISWT is a promising measure of functional exercise capacity in lung cancer. Findings need to be confirmed in a larger sample prior to translation into practice. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 12, 2015 Category: Respiratory Medicine Authors: Catherine GrangerLinda DenehySelina ParryJoel MartinTim DimitriadisMaeve SorohanLouis Irving Source Type: research

Outcome of corticosteroid administration in autoimmune pulmonary alveolar proteinosis: a retrospective cohort study
Background: Although no report has demonstrated the efficacy of corticosteroid therapy for autoimmune pulmonary alveolar proteinosis (aPAP), we sometimes encounter patients who have received this therapy for various reasons. However, as corticosteroids can suppress alveolar macrophage function, corticosteroid therapy might worsen disease severity and increase the risk of infections. Methods: For this retrospective cohort study, we sent a screening form to 165 institutions asking for information on aPAP patients treated with corticosteroids. Of the resulting 45 patients screened, 31 were enrolled in this study. We collected...
Source: BMC Pulmonary Medicine - August 12, 2015 Category: Respiratory Medicine Authors: Keiichi AkasakaTakahiro TanakaNobutaka KitamuraShinya OhkouchiRyushi TazawaToshinori TakadaToshio IchiwataEtsuro YamaguchiMasaki HiroseToru AraiKentaro NakanoTakahito NeiHaruyuki IshiiTomohiro HandaYoshikazu InoueKoh Nakata Source Type: research

GATA2 deficiency in children and adults with severe pulmonary alveolar proteinosis and hematologic disorders
Conclusions: In children and adults with severe GM-CSF negative PAP a close cooperation between pneumologists and hemato-oncologists is needed to diagnose the underlying diseases, some of which are caused by mutations of transcription factor GATA2. Treatment with whole lung lavages as well as stem cell transplant may be successful. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - August 12, 2015 Category: Respiratory Medicine Authors: Matthias GrieseRalf ZarbockUlrich CostabelJenna HildebrandtDirk TheegartenMichael AlbertAntonia ThielAndrea SchamsJoanna LangeKatazyrna KrenkeTraudl WesselakCarola SchönMatthias KapplerHelmut BlumStefan KrebsAndreas JungCarolin KrönerChristoph KleinIlar Source Type: research

Ventilator-associated Pneumonia caused by commensal oropharyngeal a retrospective Analysis of a prospectively collected Database
Background: The significance of commensal oropharyngeal flora (COF) as a potential cause of ventilator-associated pneumonia (VAP) is scarcely investigated and consequently unknown. Therefore, the aim of this study was to explore whether COF may cause VAP. Methods: Retrospective clinical, microbiological and radiographic analysis of all prospectively collected suspected VAP cases in which bronchoalveolar lavage fluid exclusively yielded ≥ 10 4  cfu/ml COF during a 9.5-year period. Characteristics of 899 recent intensive care unit (ICU) admissions were used as a reference population. Results: Out ...
Source: BMC Pulmonary Medicine - August 12, 2015 Category: Respiratory Medicine Authors: Johannes ScholteJohan van der VeldeCatharina LinssenHelke van DesselDennis BergmansPaul SavelkoulPaul RoekaertsWalther van Mook Source Type: research

Y-27632 is associated with corticosteroid-potentiated control of pulmonary remodeling and inflammation in guinea pigs with chronic allergic inflammation
Background: Previously, we showed that treatment with the Rho-kinase inhibitor Y-27632 was able to control airway responsiveness, inflammation, remodeling, and oxidative stress in an animal model of asthma, suggesting that this drug is beneficial in asthma. However, studies evaluating the effects of these inhibitors in conjunction with corticosteroids on chronic pulmonary inflammation have not been conducted. Therefore, we evaluated the effects of treatment with the Rho-kinase inhibitor Y-27632, with or without concurrent dexamethasone treatment, on airway and lung tissue mechanical responses, inflammation, extracellular m...
Source: BMC Pulmonary Medicine - August 12, 2015 Category: Respiratory Medicine Authors: Patricia PigatiRenato RighettiSamantha PossaBeatriz RomanholoAdriana RodriguesAnelize dos SantosDébora XistoMariana AntunesCarla PradoEdna LeickMilton de Arruda MartinsPatrícia RoccoIolanda de Fátima Lopes Calvo Tibério Source Type: research

Nanocomplexes for gene therapy of respiratory diseases: Targeting and overcoming the mucus barrier
Publication date: October 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 34 Author(s): Sante Di Gioia, Adriana Trapani, Stefano Castellani, Annalucia Carbone, Giuliana Belgiovine, Emanuela Fabiola Craparo, Giovanni Puglisi, Gennara Cavallaro, Giuseppe Trapani, Massimo Conese Gene therapy, i.e. the delivery and expression of therapeutic genes, holds great promise for congenital and acquired respiratory diseases. Non-viral vectors are less toxic and immunogenic than viral vectors, although they are characterized by lower efficiency. However, they have to overcome many barriers, including inflam...
Source: Pulmonary Pharmacology and Therapeutics - August 12, 2015 Category: Respiratory Medicine Source Type: research

Concomitant Tracheal and subcutaneous glomus tumor: Case report and review of the literature
We describe a case of concomitant subcutaneous and tracheal glomus tumor that underwent successful endoscopic resection. A 48-year old male with a left forearm subcutaneous mass presented with hemoptysis. A chest CT scan demonstrated a polypoid tracheal lesion. He underwent a bronchoscopic resection. A biopsy revealed a glomus tumor, which was the same type of neoplasm that was found on the forearm biopsy. Glomus tumors are rarely found in the respiratory tract. Only 49 cases have been described. The majority of the glomus tumors arise from the lower posterior tracheal wall with no extraluminal extension. Bronchoscopic res...
Source: Respiratory Medicine Case Reports - August 12, 2015 Category: Respiratory Medicine Source Type: research

Quantifying the shape of the maximal expiratory flow-volume curve in mild COPD
Publication date: Available online 12 August 2015 Source:Respiratory Physiology & Neurobiology Author(s): Paolo B. Dominelli, Glen E. Foster, Jordan A. Guenette, Hans C. Haverkamp, Neil D. Eves, Giulio S. Dominelli, William R. Henderson, Denis E. O'Donnell, A.William Sheel Maximal expiratory flow-volume (MEFV) curve evaluation using absolute and percent predicted values of flow and volume are used to diagnose respiratory disease, but the shape of the curve is rarely used. Three mathematical methods were used to quantify shape of MEFV curves in subjects with mild COPD (n=19) and matched healthy controls (...
Source: Respiratory Physiology and Neurobiology - August 12, 2015 Category: Respiratory Medicine Source Type: research

Simultaneous monitoring of intratidal compliance and resistance in mechanically ventilated piglets: a feasibility study in two different study groups
Publication date: Available online 11 August 2015 Source:Respiratory Physiology & Neurobiology Author(s): Sarah Buehler, Stefan Schumann, László Vimláti, Michael Lichtwarck-Aschoff, Josef Guttmann Compliance measures the force counteracting parenchymal lung distension. In mechanical ventilation, intratidal compliance-volume (C(V)-) profiles therefore change depending on PEEP, tidal volume (VT), and underlying mechanical lung properties. Resistance counteracts gas flow through the airways. Due to anatomical linking between parenchyma and airways, intratidal resistance-volume (R(V))-profiles are hypothesise...
Source: Respiratory Physiology and Neurobiology - August 12, 2015 Category: Respiratory Medicine Source Type: research