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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 19.

Management of Sleep Apnea without High Pretest Probability or with Comorbidities by Three Nights of Portable Sleep Monitoring
Conclusions:Three consecutive nights of portable monitoring at home evaluated by a qualified sleep specialist is useful for the management of patients without high pretest probability of obstructive sleep apnea or with comorbidities.Clinical Trial Registration: http://www.clinicaltrials.gov, registration number: NCT01820156 Citation: Guerrero A, Embid C, Isetta V, Farre R, Duran-Cantolla J, Parra O, Barbé F, Montserrat JM, Masa JF. Management of sleep apnea without high pretest probability or with comorbidities by three nights of portable sleep monitoring. SLEEP 2014;37(8):1363-1373. (Source: Sleep)
Source: Sleep - July 31, 2014 Category: Sleep Medicine Source Type: research

Comparative analysis of mucosal immunity to Mycoplasma hyopneumoniae in Jiangquhai porcine lean strain and DLY piglets.
In conclusion, JQHPL pigs exhibits higher resistance to M. hyopneumoniae compared to DLY. It is possible that this characteristic is caused by the faster and stronger mucosal immunity phenotype of the JQHPL strain. PMID: 25061745 [PubMed - in process] (Source: Genetics and Molecular Research)
Source: Genetics and Molecular Research - July 31, 2014 Category: Genetics & Stem Cells Authors: Hua LZ, Wu YZ, Bai FF, William KK, Feng ZX, Liu MJ, Yao JT, Zhang X, Shao GQ Tags: Genet Mol Res Source Type: research

Short-Term Effects of Fine Particulate Air Pollution on Hospital Admissions for Respiratory Diseases: A Case-Crossover Study in a Tropical City
(Source: Journal of Toxicology and Environmental Health Part A)
Source: Journal of Toxicology and Environmental Health Part A - July 31, 2014 Category: Environmental Health Authors: TsaiChiuLiouYang Source Type: research

Mandible behaviour interpretation during wakefulness, sleep and sleep‐disordered breathing
This study aimed to assess (1) the training of independent scorers to recognize the signal specificities; (2) intrascorer reproducibility and (3) interscorer variability. MM was collected in the mid‐sagittal plane of the face of 40 patients. The typical MM was extracted and classified into seven distinct pattern classes: active wakefulness (AW), quiet wakefulness or quiet sleep (QW/S), sleep snoring (SS), sleep obstructive events (OAH), sleep mixed apnea (MA), respiratory related arousal (RERA) and sleep central events (CAH). Four scorers were trained; their diagnostic capacities were assessed on two reading sessions. Th...
Source: Journal of Sleep Research - July 31, 2014 Category: Neurology Authors: Gisèle Maury, Frédéric Senny, Laurent Cambron, Adelin Albert, Laurence Seidel, Robert Poirrier Tags: Regular Research Paper Source Type: research

Autonomic cardiovascular regulation and cortical tone
This study aimed to investigate interactions between tonic cortical arousal and features of autonomic cardiovascular regulation. In 50 healthy subjects, the power spectrum of the spontaneous EEG was obtained at resting state. Concurrently, respiratory sinus arrhythmia (RSA), baroreflex sensitivity (BRS) and R‐wave to pulse interval (RPI) were recorded as indices of cardiovascular control. At the bivariate level, only a negative correlation between beta power recorded at frontal electrode positions and RPI was found. However, when common variance of BRS and RSA was controlled for in multiple regression analyses, a positiv...
Source: Clinical Physiology and Functional Imaging - July 31, 2014 Category: Radiology Authors: Stefan Duschek, Jana Wörsching, Gustavo A. Reyes del Paso Tags: Original Article Source Type: research

AstraZeneca stocks respiratory and cancer pipelines
A $2bn deal with Almirall and a raft of acquisitions and partnership deals bulk up two focus areas for the company (Source: Chemistry World | Latest News)
Source: Chemistry World | Latest News - July 31, 2014 Category: Chemistry Authors: Phillip Broadwith Source Type: research

Antibiotic prescribing by telephone in primary care
ConclusionsOverall, one in every eight antibiotics was prescribed via telephone encounter. These data highlight the need to include the impact of this practice in analysis of outcomes associated with outpatient antibiotic prescribing and to incorporate telephonic prescribing into guidelines facilitating appropriate antibiotic use. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - July 31, 2014 Category: Drugs & Pharmacology Authors: Edward Ewen, Vincent J. Willey, Paul Kolm, William F. McGhan, Marci Drees Tags: Original Report Source Type: research

Association between particulate matter and its chemical constituents of urban air pollution and daily mortality or morbidity in Beijing City.
In this study, we examined the role of particulate matters and its key chemical components of fine particles on both mortality and morbidity in Beijing. We applied several overdispersed Poisson generalized nonlinear models, adjusting for time, day of week, holiday, temperature, and relative humidity, to investigate the association between risk of mortality or morbidity and particulate matters and its constituents in Beijing, China, for January 2005 through December 2009. Particles and several constituents were associated with multiple mortality or morbidity categories, especially on respiratory health. For a 3-day lag, the...
Source: Environmental Science and Pollution Research International - July 31, 2014 Category: Environmental Health Authors: Li P, Xin J, Wang Y, Li G, Pan X, Wang S, Cheng M, Wen T, Wang G, Liu Z Tags: Environ Sci Pollut Res Int Source Type: research

Zinc and Particulate Methane Monooxygenase [Protein Structure and Folding]
Particulate methane monooxygenase (pMMO) is a membrane-bound metalloenzyme that oxidizes methane to methanol in methanotrophic bacteria. Zinc is a known inhibitor of pMMO, but the details of zinc binding and the mechanism of inhibition are not understood. Metal binding and activity assays on membrane-bound pMMO from Methylococcus capsulatus (Bath) reveal that zinc inhibits pMMO at two sites that are distinct from the copper active site. The 2.6 Å resolution crystal structure of Methylocystis species strain Rockwell pMMO reveals two previously undetected bound lipids, and metal soaking experiments identify likely locations...
Source: Journal of Biological Chemistry - July 31, 2014 Category: Chemistry Authors: Sirajuddin, S., Barupala, D., Helling, S., Marcus, K., Stemmler, T. L., Rosenzweig, A. C. Tags: Enzymology Source Type: research

CD38 Mediates Angiotensin II-induced Intracellular Ca(2+) Release in Rat Pulmonary Arterial Smooth Muscle Cells.
This study sought to characterize its roles in angiotension II (Ang II)-induced Ca2+ release (AICR) in PASMCs. Examination of CD38 expression in various rat arteries found high levels of CD38 mRNA and protein in pulmonary arteries. Ang II elicited Ca2+ response consisted of extracellular Ca2+ influx and intracellular Ca2+ release in PASMCs. AICR activated in the absence of extracellular Ca2+ was reduced by pharmacological or siRNA inhibition of CD38. It was also reduced by the cADPR-antagonist 8-bromo-cADPR or ryanodine; and by the NAADP-antagonist Ned-19 or disruption of endolysosomal Ca2+ stores with the vacuolar H+-ATPa...
Source: American Journal of Respiratory Cell and Molecular Biology - July 31, 2014 Category: Molecular Biology Authors: Lee S, Paudel O, Jiang Y, Yang XR, Sham JS Tags: Am J Respir Cell Mol Biol Source Type: research

Common Polymorphisms in the CD43 Gene Region Are Associated With Tuberculosis Disease and Mortality.
We examined whether 11 haplotype-tagging SNPs in the CD43 gene region were associated with tuberculous meningitis (TBM) and pulmonary (PTB) tuberculosis in Vietnam. Three SNPs from the CD43 gene region were associated with tuberculosis susceptibility with a genotypic model. The association fit a recessive genetic model and was greater for TBM than PTB (for TBM: rs4788172 (OR 1.64, 95% CI 1.04, 2.59), rs17842268 (OR 2.20, 95% CI 1.29, 3.76), and rs12596308 (OR 2.38, 95% CI 1.47, 3.89). Among TBM cases, rs17842268 was associated with decreased survival (HR=2.7; CI 95% 1.1-6.5; p=0.011). In addition, rs12596308 and rs17842268...
Source: American Journal of Respiratory Cell and Molecular Biology - July 31, 2014 Category: Molecular Biology Authors: Campo M, Randhawa AK, Dunstan S, Farrar J, Caws M, Bang ND, Lan NN, Chau TT, Horne DJ, Thuong NT, Thwaites GE, Hawn TR Tags: Am J Respir Cell Mol Biol Source Type: research

Mandible behaviour interpretation during wakefulness, sleep and sleep-disordered breathing.
This study aimed to assess (1) the training of independent scorers to recognize the signal specificities; (2) intrascorer reproducibility and (3) interscorer variability. MM was collected in the mid-sagittal plane of the face of 40 patients. The typical MM was extracted and classified into seven distinct pattern classes: active wakefulness (AW), quiet wakefulness or quiet sleep (QW/S), sleep snoring (SS), sleep obstructive events (OAH), sleep mixed apnea (MA), respiratory related arousal (RERA) and sleep central events (CAH). Four scorers were trained; their diagnostic capacities were assessed on two reading sessions. The ...
Source: Journal of Sleep Research - July 31, 2014 Category: Sleep Medicine Authors: Maury G, Senny F, Cambron L, Albert A, Seidel L, Poirrier R Tags: J Sleep Res Source Type: research

Biography, pandemic time and risk: Pregnant women reflecting on their experiences of the 2009 influenza pandemic
During the 2009 H1N1 pandemic, it was identified that women in the third trimester of pregnancy were particularly at risk of serious respiratory distress. At-risk women were advised to seek vaccination, avoid contact with anyone unwell, maintain hygiene routines and stop smoking. We examine this situation of emergent and intense risk produced at the intersection of individual biography and the historical event of a public health emergency. We examine how pregnant women took account of risk, how they negotiated incomplete and at times contradictory advice and shaped courses of action that assisted them to manage the emergin...
Source: Health: - July 31, 2014 Category: Global & Universal Authors: Lohm, D., Flowers, P., Stephenson, N., Waller, E., Davis, M. D. Tags: Articles Source Type: research

LL-37 modulates human neutrophil responses to influenza A virus.
In this study, we explore how LL-37 affects interactions of IAV with human neutrophils. LL-37 did not alter neutrophil uptake of IAV but significantly increased neutrophil H2O2 responses to the virus. IAV stimulated production of NETs in vitro, and this response was increased by preincubating the virus with LL-37. NADPH-oxidase blockade did not reduce IAV-induced NET formation or the increased NET response stimulated by LL-37 + IAV. The increased respiratory burst and NET responses were, however, inhibited by preincubating cells with a formyl peptide receptor blocker, indicating that LL-37 engages these receptors when comp...
Source: Journal of Leukocyte Biology - July 31, 2014 Category: Hematology Authors: Tripathi S, Verma A, Kim EJ, White MR, Hartshorn KL Tags: J Leukoc Biol Source Type: research

Coupling of Heart Rate and Systolic Blood Pressure in Hypertensive Pregnancy.
Conclusions: The BSPPA method a) provides improved risk stratification for pregnant women suffering from hypertension and PE, b) increases the ability to diagnose pathological changes, and c) could contribute substantially to the differential diagnosis of hypertensive pregnancy disorders. PMID: 25077755 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Voss A, Fischer C, Schroeder R Tags: Methods Inf Med Source Type: research

Robust Detection of Sleep Apnea from Holter ECGs. Joint Assessment of Modulations in QRS Amplitude and Respiratory Myogram Interference.
Conclusions: Joint occurrence of LF-modulations in QRSA and RMI is a characteristic feature of SRBD that is robustly quantified by the jLSI and permits reliable and reproducible detection of sleep apnea in very heterogeneous settings. PMID: 25077646 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Maier C, Wenz H, Dickhaus H Tags: Methods Inf Med Source Type: research

Modeling and Quantification of Repolarization Feature Dependency on Heart Rate.
Conclusions: In this work an efficient estimation of the parameters of a model aimed at characterizing rate adaptation of repolarization features has been proposed. The Tpe interval has been shown to be rate related and with a shorter memory lag than the QT interval. PMID: 25077546 [PubMed - as supplied by publisher] (Source: Methods of Information in Medicine)
Source: Methods of Information in Medicine - July 31, 2014 Category: Information Technology Authors: Minchole A, Zacur E, Pueyo E, Laguna P Tags: Methods Inf Med Source Type: research

Polymeric Immunoglobulin Receptor Downregulation in COPD: Persistence in the Cultured Epithelium and Role of Transforming Growth Factor-β.
Conclusions: pIgR downregulation in COPD correlates with disease severity, and the bronchial epithelium reconstituted in vitro from these patients retains its aberrant imprinting for pIgR expression. This study also links pIgR downregulation to TGF-β-driven reprogramming of the bronchial epithelium, which results in impaired lung IgA immunity in COPD patients. PMID: 25078120 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 31, 2014 Category: Respiratory Medicine Authors: Gohy ST, Detry BR, Lecocq M, Bouzin C, Weynand BA, Amatngalim GD, Sibille YM, Pilette C Tags: Am J Respir Crit Care Med Source Type: research

Overview to the Management of Cough: CHEST Guideline and Expert Panel Report.
Abstract ABSTRACT: This overview will demonstrate that cough is a common and potentially expensive health care problem. Improvement in the quality of care of those with cough has been the focus of study for a variety of disciplines in medicine. The purpose of the Cough Guideline and Expert Panel is to synthesize current knowledge in a form that will aide clinical decision making for the diagnosis and management of cough across disciplines and also identify gaps in knowledge and treatment options. PMID: 25080295 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Irwin RS, French CT, Lewis SZ, Diekemper RL, Gold PM Tags: Chest Source Type: research

Increased risk of radiographic emphysema in HIV is associated with elevated soluble CD14 and nadir CD4.
Conclusions:HIV is an independent risk factor for radiographic emphysema. Emphysema severity was significantly greater among HIV-infected individuals. Among those with HIV, nadir CD4 <200 and elevated soluble CD14 were associated with emphysema, highlighting potential mechanisms linking HIV with emphysema. Background: The association between HIV and emphysema remains incompletely understood. We sought to determine whether HIV is an independent risk factor for emphysema severity and whether markers of HIV severity and systemic biomarkers of inflammation (interleukin-6), altered coagulation (D-dimer) and immune activa...
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Soo Hoo GW, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice A, Crothers K Tags: Chest Source Type: research

Is a raised bicarbonate, without hypercapnia, part of the physiological spectrum of obesity-related hypoventilation?
ConclusionThese data suggest that obese individuals with a raised base excess, despite normocapnia whilst awake, should probably be regarded as having early obesity-related hypoventilation. This has important implications for clinical management as well as randomized controlled treatment trials, as they may represent a group with a more reversible disease process. Introduction: Obesity hypoventilation syndrome (OHS) conventionally includes awake hypercapnia, but an isolated raised bicarbonate, even in the absence of awake hypercapnia, may represent evidence of 'early' OHS. We have investigated whether such individuals ...
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Manuel AR, Hart N, Stradling JR Tags: Chest Source Type: research

The Prognostic Value of Undetectable Highly Sensitive Cardiac Troponin I in Patients with Acute Pulmonary Embolism.
Conclusions:Highly sensitive cTnI assay provides an excellent prognostic negative predictive value, thus it has a role in identifying candidates for out-of-hospital treatment of acute PE. Background: Elevated cardiac troponin levels have been shown to be associated with adverse outcome in patients with acute pulmonary embolism (PE). However, there is less data addressing the management implications of undetectable cardiac troponin-I (cTnI) using a highly sensitive assay. We hypothesized that undetectable cTnI predicts very low in-hospital adverse event rates. Methods: In a retrospective cohort study, we classified ...
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Hakemi EU, Alyousef T, Dang G, Hakmei J, Doukky R Tags: Chest Source Type: research

Factors predictive of airflow obstruction among Veterans with presumed empiric diagnosis and treatment of COPD.
Conclusions:Comorbidities associated with somatic complaints of dyspnea were associated with a lower risk of having airflow limitation, suggesting empiric diagnosis and treatment of COPD may lead to inappropriate treatment for individuals who do not have airflow obstruction. Rationale: Despite guideline recommendations, patients suspected of having chronic obstructive pulmonary disease (COPD) are often treated empirically rather than undergoing spirometry to confirm airflow obstruction (AFO). Accurate diagnosis and treatment are essential to provide high quality, value-oriented care. We sought to identify predictors as...
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Collins BF, Feemster LC, Rinne S, Au DH Tags: Chest Source Type: research

Would triage predictors perform better than first-come-first-served in pandemic ventilator allocation?
Conclusions -Performance of unvalidated pandemic ventilator triage predictors is unknown and possibly inferior to first-come-first-served allocation. Poor performance of unvalidated predictors proposed for triage would represent an inadequate plan for stewarding scarce resources and would deprive some patients of fair access to a ventilator, thus falling short of sound ethical foundations. Background -: In a pandemic, needs for ventilators might overwhelm the limited supply. Outcome predictors have been proposed to guide ventilator triage allocation decisions. However, pandemic triage predictors have not been validated...
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Kanter RK Tags: Chest Source Type: research

Urinary Albumin-Creatinine Ratio, Estimated Glomerular Filtration Rate, and All-Cause Mortality among US Adults with Obstructive Lung Function.
Conclusions: UACR and eGFR, in continuous form, were associated with all-cause mortality among US adults with OLF. PMID: 25079336 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 31, 2014 Category: Respiratory Medicine Authors: Ford ES Tags: Chest Source Type: research

Sleep and Breathing
This article discusses the regulation of breathing during sleep in health and associated comorbid conditions. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - July 31, 2014 Category: Respiratory Medicine Authors: Kelly Newton, Vipin Malik, Teofilo Lee-Chiong Source Type: research

Sleep and Respiratory Physiology in Adults
This article reviews mechanisms of central control of respiration and normal upper and lower airway physiology. Understanding sleep-related changes in respiratory physiology will help in developing new therapies to prevent hypoventilation in susceptible populations. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - July 31, 2014 Category: Respiratory Medicine Authors: Mudiaga Sowho, Jason Amatoury, Jason P. Kirkness, Susheel P. Patil Source Type: research

Sleep in Asthma
Many patients with asthma experience worsening of symptoms at night. Understanding the mechanism of nocturnal asthma and the factors that exacerbate asthma during sleep would lead to better management of the condition. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - July 31, 2014 Category: Respiratory Medicine Authors: Wajahat H. Khan, Vahid Mohsenin, Carolyn M. D'Ambrosio Source Type: research

Ibuprofen and indomethacin in neonates
Pacifici GM (Source: International Journal of COPD)
Source: International Journal of COPD - July 30, 2014 Category: Respiratory Medicine Source Type: research

Relationship Between Functional Hamstring: Quadriceps Ratios and Running Economy in Highly Trained and Recreational Female Runners
Abstract: Sundby, ØH and Gorelick, MLS. Relationship between functional hamstring:quadriceps ratios and running economy in highly trained and recreational female runners. J Strength Cond Res 28(8): 2214–2227, 2014—The purpose of this study was to investigate the relationship between running economy (RE), functional hamstring:quadriceps peak torque ratios (f-H:Q), and flexibility among female runners. Seven highly trained (HT) female runners (age: 25.7 ± 4.7 years, V[Combining Dot Above]O2peak of 62.0 ± 4.8 ml·kg−1·min−1) and 11 recreational female runners (age of 28.8 ± 5.6 years, V[Combining Dot Above]O2peak...
Source: Journal of Strength and Conditioning Research - July 30, 2014 Category: Sports Medicine Tags: Original Research Source Type: research

Metabolic, Cardiovascular, and Perceptual Responses to a Thermogenic Nutritional Supplement at Rest, During Exercise, and Recovery in Men
Abstract: Bergstrom, HC, Housh, TJ, Traylor, DA, Lewis, Jr RW, Cochrane, KC, Jenkins, NDM, Schmidt, RJ, Johnson, GO, Housh, DJ, and Cramer, JT. Metabolic, cardiovascular, and perceptual responses to a thermogenic nutritional supplement at rest, during exercise, and recovery in men. J Strength Cond Res 28(8): 2154–2163, 2014—Twenty-one men (mean ± SD; age = 23.5 ± 2.6 years, BMI = 26.0 ± 2.4 kg·m−2) completed this randomized, double-blinded, placebo-controlled, crossover study to examine acute responses to a thermogenic nutritional supplement. Each testing session included: (a) 30 minutes resting, followed by plac...
Source: Journal of Strength and Conditioning Research - July 30, 2014 Category: Sports Medicine Tags: Original Research Source Type: research

Acute Effect of Intensity Fluctuation on Energy Output and Substrate Utilization
Abstract: Kang, J, Mangine, GT, Ratamess, NA, Faigenbaum, AD, and Hoffman, JR. Acute effect of intensity fluctuation on energy output and substrate utilization. J Strength Cond Res 28(8): 2136–2144, 2014—Exercise routines in which intensity fluctuates, such as Spinning and Treading, are gaining in popularity in fitness industry. However, literature on how this dynamic protocol may affect the exercise metabolism is lacking. The present investigation was undertaken to examine the effect of intensity fluctuation and its magnitude on oxygen uptake and substrate utilization during exercise and recovery. Fifteen men and 15 w...
Source: Journal of Strength and Conditioning Research - July 30, 2014 Category: Sports Medicine Tags: Original Research Source Type: research

Frequent nocturnal awakening in children: prevalence, risk factors, and associations with subjective sleep perception and daytime sleepiness
Conclusion: FNA was associated with poor sleep and daytime sleepiness. Compared to sleep environment and family susceptibility, chronic health problems, poor psychosocial condition, and poor sleep hygiene had greater impact on FNA, indicating childhood FNA could be partly prevented by health promotion, by psychological intervention, and by improving sleep hygiene routine. (Source: BMC Psychiatry - Latest articles)
Source: BMC Psychiatry - Latest articles - July 30, 2014 Category: Psychiatry Authors: Liwen LiJiwei RenLei ShiXinming JinChonghuai YanFan JiangXiaoming ShenShenghui Li Source Type: research

Supraglottic airway devices vs tracheal intubation in children: a quantitative meta‐analysis of respiratory complications
ConclusionsThis meta‐analysis found that the use of laryngeal mask airway in pediatric anesthesia results in a decrease in a number of common postanesthetic complications. It is therefore a valuable device for the management of the pediatric airway. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - July 30, 2014 Category: Anesthesiology Authors: Virginie Luce, Hakim Harkouk, Christopher Brasher, Daphné Michelet, Julie Hilly, Matthieu Maesani, Thierno Diallo, Nyamjargal Mangalsuren, Yves Nivoche, Souhayl Dahmani Tags: Review Article Source Type: research

Single detection of human bocavirus 1 with a high viral load in severe respiratory tract infections in previously healthy children
Conclusions: HBoV1 at a high viral load is not frequently found in co-detection with other respiratory viruses, and a single detection with a high viral load could be an etiological agent of severe respiratory tract infections. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 30, 2014 Category: Infectious Diseases Authors: Lili ZhouShouyan ZhengQiuyan XiaoLuo RenXiaohong XieJian LuoLijia WangAilong HuangWei LiuEnmei Liu Source Type: research

Differential expression of Homeobox C11 protein in water buffalo Bubalus bubalis and its putative 3D structure
Conclusions: Present study augments our understanding on the specific expression of HOXC11 protein in kidney and lung in water buffalo. The fifteen DNA interacting residues reported herein provide an opportunity to establish much broader structural and functional perspectives of HOXC11 protein in the context of genome analysis in general and animal biotechnology in particular. (Source: BMC Genomics - Latest articles)
Source: BMC Genomics - Latest articles - July 30, 2014 Category: Genetics & Stem Cells Authors: Monal SharmaLeena RawalDeepak PanwarNeeta SehgalSher Ali Source Type: research

A Simple Paper-Based Lab-on-a-Chip for the Detection of a Highly Pathogenic Strain of Porcine Reproductive and Respiratory Syndrome Virus
Piyasak Chaumpluk, Annop Suriyasomboon Paper-based laboratory-on-a-chip has become a focusing issue for point of care test. So far, several platforms had been demonstrated, but are limited to chemical tests. The chip here combined reverse transcription loop-mediated isothermal DNA amplification (RT-LAMP) and colorimetric DNA detection, allowing effective assay of virus at a low cost. (Source: Australian Journal of Chemistry)
Source: Australian Journal of Chemistry - July 30, 2014 Category: Chemistry Authors: Piyasak ChaumplukAnnop Suriyasomboon Source Type: research

Comparison of human metapneumovirus, respiratory syncytial virus and Rhinovirus respiratory tract infections in young children admitted to hospital
Respiratory Syncytial Virus (RSV), Human metapneumovirus (HMPV), and Rhinoviruses (RV) are frequent causes of respiratory tract infections in young children. We compared laboratory and clinical findings in children with comparable age distribution and hospitalized due to RSV, HMPV or RV infections. Viral pathogens were detected by a quantitative real time PCR from nasopharyngeal aspirates. No significant differences in the admission diagnosis, laboratory parameters, patient demographics and treatment measures between the three viral causes of respiratory illness were found. No correlation between viral load and disease sev...
Source: Journal of Medical Virology - July 30, 2014 Category: Virology Authors: O. Adams, J. Weis, K. Jasinska, M. Vogel, T. Tenenbaum Tags: Research Article Source Type: research

Genetic variation underlying common hereditary hyperbilirubinaemia (Gilbert’s syndrome) and respiratory health in the 1946 British birth cohort
Bilirubin has potent antioxidant properties in vitro and raised serum levels have been associated with lower rates of respiratory disease. The enzyme uridine diphosphate glucuronosyltransferase polypeptide 1A1 (UGT1A1) is solely responsible for clearing bilirubin from the blood and homozygosity for seven thymine-adenine (TA) repeats in the TATA box regulatory element of the UGT1A1 gene underlies a mild hereditary unconjugated hyperbilirubinaemia (Gilbert’s syndrome). Our aim was to investigate whether this genetic variation is associated with differences in respiratory health. (Source: Journal of Hepatology)
Source: Journal of Hepatology - July 30, 2014 Category: Gastroenterology Authors: Laura J. Horsfall, Rebecca Hardy, Andrew Wong, Diana Kuh, Dallas M. Swallow Source Type: research

Drowning and immersion injury
Drowning is a process resulting in primary respiratory impairment from submersion/immersion in a liquid medium. It is a frequent cause of unintentional injury deaths and public health initiatives to prevent drowning are important as there are no specific interventions proven to improve outcomes in drowning victims. Risk factors for drowning include inadequate supervision, recreational or occupational access to water, risk-taking behaviour and underlying medical conditions. Pathophysiological events in the process of drowning are secondary to hypoxaemia that results from the immersion injury. (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - July 30, 2014 Category: Anesthesiology Authors: F Eduardo Martinez, Andrew J. Hooper Source Type: research

Topical Acidic Cream Prevents The Development of Atopic Dermatitis‐ and Asthma‐Like Lesions in Murine Model
This article is protected by copyright. All rights reserved. (Source: Experimental Dermatology)
Source: Experimental Dermatology - July 30, 2014 Category: Dermatology Authors: Hae‐Jin Lee, Na Young Yoon, Noo Ri Lee, Minyoung Jung, Dong Hye Kim, Eung Ho Choi Tags: Regular Article Source Type: research

Contributions of Comorbid Diabetes to Sleep Characteristics, Daytime Symptoms, and Physical Function Among Patients With Stable Heart Failure.
CONCLUSIONS:: Comorbid DM contributes independent and additive effects on sleep disturbances and poor physical functioning in patients with stable HF. PMID: 25078876 [PubMed - as supplied by publisher] (Source: The Journal of Cardiovascular Nursing)
Source: The Journal of Cardiovascular Nursing - July 30, 2014 Category: Nursing Authors: Fritschi C, Redeker NS Tags: J Cardiovasc Nurs Source Type: research

In vitro permeation of platinum and rhodium through Caucasian skin.
This study aimed to investigate the in vitro permeation of platinum and rhodium through intact Caucasian skin. A donor solution of 0.3mg/ml of metal, K2PtCl4 and RhCl3 respectively, was applied to the vertical Franz diffusion cells with full thickness abdominal skin. The receptor solution was removed at various intervals during the 24h experiment, and analysed with high resolution ICP-MS. Skin was digested and analysed by ICP-OES. Results indicated cumulative permeation with prolonged exposure, with a significantly higher mass of platinum permeating after 24h when compared to rhodium. The mass of platinum retained inside t...
Source: Toxicology in Vitro - July 30, 2014 Category: Toxicology Authors: Franken A, Eloff FC, Du Plessis J, Badenhorst CJ, Jordaan A, Du Plessis JL Tags: Toxicol In Vitro Source Type: research

Post-exercise whole-body heat stress additively enhances endurance training-induced mitochondrial adaptations in mouse skeletal muscle.
Abstract A recent study demonstrated that heat stress induces mitochondrial biogenesis in C2C12 myotubes, thereby implying that heat stress may be an effective treatment to enhance endurance training-induced mitochondrial adaptations in skeletal muscle. However, whether heat stress actually induces mitochondrial adaptations in skeletal muscle in vivo is unclear. We herein report the novel findings that 1) whole-body heat stress produced by exposure of ICR mice to a hot environment (40 ºC, 30 min/day, 5 days/week, 3 weeks) induced mitochondrial adaptations such as increased mitochondrial enzyme activity (citrate sy...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 30, 2014 Category: Physiology Authors: Tamura Y, Matsunaga Y, Masuda H, Takahashi Y, Takahashi Y, Terada S, Hoshino D, Hatta H Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Impaired heterologous immunity in aged ferrets during sequential influenza A H1N1 infection.
Abstract The major burden of influenza morbidity resides within the elderly population. The challenge managing influenza-associated illness in the elderly is the decline of immune function, where mechanisms leading to immunological senescence have not been elucidated. To better represent the immune environment, we investigated clinical morbidity and immune function during sequential homologous and heterologous H1N1 influenza infection in an aged ferret model. Our findings demonstrated experimentally that aged ferrets had significant morbidity during monosubtypic heterologous 2° challenge with significant weight lo...
Source: Virology - July 30, 2014 Category: Virology Authors: Paquette SG, Huang SS, Banner D, Xu L, Leόn A, Kelvin AA, Kelvin DJ Tags: Virology Source Type: research

Heme oxygenase-1 acts as an antiviral factor for porcine reproductive and respiratory syndrome virus infection and over-expression inhibits virus replication in vitro.
Abstract Virus replication depends upon host-cell processes in infected cells, and this is true for porcine reproductive and respiratory syndrome virus (PRRSV), the causative agent of PRRS that is a worldwide threat to the swine industry. Heme oxygenase-1 (HO-1) is a ubiquitously expressed inducible isoform of the first and rate-limiting enzyme for heme degradation. Our previous research suggested that HO-1 may play an important role in PRRSV infection. However, the function of HO-1 in PRRSV infection is unclear. In the present study, Marc-145, PK-15(CD163) cell lines and porcine alveolar macrophages (PAMs) were us...
Source: Antiviral Research - July 30, 2014 Category: Virology Authors: Xiao S, Zhang A, Zhang C, Ni H, Gao J, Wang C, Zhao Q, Wang X, Wang X, Ma C, Liu H, Li N, Mu Y, Sun Y, Zhang G, Hiscox JA, Hsu WH, Zhou EM Tags: Antiviral Res Source Type: research

Nasal saline as a placebo in chronic rhinosinusitis
I read with interest Mainz et al’s article in the July issue of your journal [1]. The authors concluded that; vibrating sinonasal inhalation of dornase alfa reduces rhinosinusitis symptoms in cystic fibrosis. We question the interpretation of the results. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 30, 2014 Category: Respiratory Medicine Authors: Ahmet Karadag, Ferhat Catal Source Type: research