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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Fractional exhaled nitric oxide‐guided algorithm for children with asthma
Summary Fractional exhaled nitric oxide (FeNO) is a surrogate marker of eosinophilic airway inflammation in asthma. The randomized controlled parallel study published by Peirsman et al combined GINA guidelines and FeNO level in guiding drug treatment in children with mild to severe asthma. Their target was to control the FeNO level below 20 ppb. The FeNO group resulted in increasing the dosage of inhaled corticosteroid and the usage of leukotriene receptor antagonist. However, the study was not truly randomized and drug adherence was not reported. The FeNO‐guided algorithm failed to improve the primary outcome, the sym...
Source: Pediatric Pulmonology - October 18, 2014 Category: Respiratory Medicine Authors: Qun Ui Lee Tags: Letter to the Editor Source Type: research

Does the 2013 GOLD classification improve the ability to predict lung function decline, exacerbations and mortality: a post-hoc analysis of the 4-year UPLIFT trial
Conclusions: The new classification system is a modest step towards a phenotype approach. It is probably an improvement for the prediction of exacerbations, but a deterioration for predicting mortality and lung function decline.Trial registration: NCT00144339 (September 2, 2005). (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 18, 2014 Category: Respiratory Medicine Authors: Lucas GoossensInge LeimerNorbert MetzdorfKarin BeckerMaureen Mölken Source Type: research

Genetic polymorphisms and risk of recurrent wheezing in pediatric age
Conclusions: This study shows a clear relationship between the risk of wheezing and polymorphisms of some genes involved in the immune response. Although further studies are needed to confirm the results, these findings may be useful for the early identification of children at the highest risk of developing recurrent episodes and possibly subsequent asthma. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 18, 2014 Category: Respiratory Medicine Authors: Susanna EspositoValentina IerardiCristina DalenoAlessia ScalaLeonardo TerranovaClaudia TagliabueWalter Peves RiosClaudio PelucchiNicola Principi Source Type: research

Severe Respiratory Illness Associated with Enterovirus D68—Missouri and Illinois, 2014
This report details an increase in cases of enterovirus D68, a cause of severe respiratory illness most commonly found in children, and one that should be considered as potentially problematic in donors or recipients. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - October 18, 2014 Category: Transplant Surgery Tags: Reports From the CDC: MMWR Source Type: research

Development and validation of a prediction model for diagnosing blood stream infections in febrile, non‐neutropenic children with cancer
ConclusionsWe developed a diagnostic prediction model for BSI in febrile pediatric oncology patients without severe neutropenia. External validation is warranted before use in clinical practice. Pediatr Blood Cancer 2014;9999:1–7© 2014 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 18, 2014 Category: Cancer & Oncology Authors: Adam J. Esbenshade, M. Cecilia Di Pentima, Zhiguo Zhao, Ayumi Shintani, Jennifer C. Esbenshade, Monique E. Simpson, Kathleen C. Montgomery, Robert B. Lindell, Haerin Lee, Ato Wallace, Kelly L. Garcia, Karel G.M. Moons, Debra L. Friedman Tags: Research Article Source Type: research

Mode of delivery and other risk factors for Escherichia coli infections in very low birth weight infants
Background: Infections in newborns remain one of the most significant problems in modern medicine. Escherichia coli is an important cause of neonatal bloodstream and respiratory tract infections and is associated with high mortality. The aim of our study was to investigate the epidemiology of E. coli infection in Polish neonatal intensive care units (NICUs) and resistance to antibiotics, with particular reference to the safety of very low birth weight infants. Methods: Continuous prospective infection surveillance was conducted in 2009-2012 in five NICUs, including 1,768 newborns whose birth weight was (Source: BMC Pediatrics)
Source: BMC Pediatrics - October 18, 2014 Category: Pediatrics Authors: Agnieszka ChmielarczykJadwiga Wójkowska-MachDorota RomaniszynPawe¿ AdamskiEwa HelwichRyszard LauterbachMonika PobiegaMaria Borszewska-KornackaEwa Gulczy¿skaAgnieszka KordekPiotr Heczko Source Type: research

Effectiveness of prayer in reducing anxiety in cancer patients
Conclusion: Prayer, therefore, proved to be an effective strategy in reducing the anxiety of the patient undergoing chemotherapy.

Objetivo: Evaluar el efecto de la plegaria sobre la ansiedad de pacientes con cáncer en tratamiento quimioterápico. Método: Estudio casi experimental con pre y post intervención. Fueron reclutados 20 pacientes hospitalizados en tratamiento de quimioterapia endovensa continua. Los voluntarios fueron evaluados por medio de encuesta, utilizándose un cuestionario de rasgos sociodemográficos, clínicos y espirituales, el Índice de Religiosidad de la Universidad de Duke - DUREL y el Inv...
Source: Revista da Escola de Enfermagem da USP - October 17, 2014 Category: Nursing Source Type: research

A Sphingosine-1 Phosphate Agonist (FTY720) Limits Trauma/Hemorrhagic Shock–Induced Multiple Organ Dysfunction Syndrome
Conclusions: FTY720 limited T/HS-induced multiple organ dysfunction syndrome (lung injury, red cell injury, and neutrophil priming) as well as T/HS lymph bioactivity, although it did not limit gut injury. (Source: Shock)
Source: Shock - October 17, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Motion Compensation for Ultrasound Thermal Imaging Using Motion-Mapped Reference Model: An in vivo Mouse Study
In this study, we aim to develop a motion compensation method for stable US thermal imaging in in vivo subjects. Based on the assumption that the major tissue motion is approximately periodic caused by respiration, we propose a motion compensation method for change in backscattered energy (CBE) with multiple reference frames. Among the reference frames, the most similar reference to the current frame is selected to subtract the respiratory-induced motions. Since exhaustive reference searching in all stored reference frames can impede real-time thermal imaging, we improve the reference searching by using a motion-mapped ref...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

Nasal Oestrosis in a Jamunapari goat
Abstract Oestrus ovis is a well-known parasite of the nasal cavities and adjoining sinuses in sheep and goats. A 3-year-old female Jamunapari goat was presented with a history of anorexia, weight loss, in-coordinated movements, nasal discharge since 10 days and two nasal bots expelled during sneezing 3 days back. Upon clinical examination the animal was dull, dysphonic, unsteady gait and having blocked nostrils with thick mucoid discharge along with an increased respiratory rate. Parasitiological examination revealed it as an O. ovis (nasal bots). The occurrence of nasal bots in a goat an...
Source: Journal of Parasitic Diseases - October 17, 2014 Category: Parasitology Source Type: research

GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers
Conclusions GAL-021 was safe and generally well tolerated with adverse events comparable with placebo except for an infusion site burning sensation. GAL-021 stimulated ventilation at the highest doses suggesting that greater infusion rates may be required for maximum PD effects. GAL-021 had PK characteristics consistent with an acute care medication. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - October 17, 2014 Category: Anesthesiology Authors: McLeod, J. F., Leempoels, J. M., Peng, S. X., Dax, S. L., Myers, L. J., Golder, F. J. Tags: Respiration And The Airway Source Type: research

Traumatic massive tension pneumothorax due to a break in the middle lobe bronchus
A patient presented respiratory failure and haemodynamic instability after falling from a height of 6 m. After a high suspicion of tension pneumothorax based on clinical status and pulmonary auscultation, the emergency physician inserted a Pneumocath (8 Fr; 2.7 mm) while in the ambulance. Once in hospital, CT scan (figure 1) showed a tension pneumothorax that caused an important left displacement of the heart, right diaphragm and hepatic silhouette. These findings led to replacing the chest tube by a thicker one (Argyle Thoracic Catheter 28 Fr; 9.3 mm). Due to the presence of massive and persistent...
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Carillo, G. A. O., Fontan, E. M. G. Tags: Radiology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ethics, Trauma Images in emergency medicine Source Type: research

Pyrethroid poisoning: features and predictors of atypical presentations
Conclusions 39.3% of pyrethroid poisoned patients had atypical presentations with the most common being respiratory failure requiring ventilator care. Predictors of atypical presentation were ingested amount >250 cc and serum lactate >3.5 mmol/L. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Cha, Y. S., Kim, H., Cho, N. H., Jung, W. J., Kim, Y. W., Kim, T. H., Kim, O. H., Cha, K. C., Lee, K. H., Hwang, S. O., Nelson, L. S. Tags: Poisoning/Injestion, Pneumonia (infectious disease), TB and other respiratory infections, Coma and raised intracranial pressure, Epilepsy and seizures, Hypertension, Pneumonia (respiratory medicine), Poisoning Original article Source Type: research

Tension pneumoperitoneum
Image case history An elderly female with peritoneal carcinomatosis of ovarian origin was resuscitated following a pulseless electrical activity (PEA) cardiac arrest. Prehospital intubation attempts were unsuccessful and the patient received bag-valve-mask ventilation. En route, paramedics reported increasing difficulty ventilating and the patient's abdomen became distended, tense and tympanitic. After emergency department arrival, a postintubation radiograph of the chest was obtained (figure 1). Tension pneumoperitoneum was diagnosed and abdominal decompression with a supraumbilical needle was performed. Despite initial i...
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Williams, D. T., Manoochehri, P., Kim, H. T. Tags: Patients, Drugs: cardiovascular system, Radiology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ethics, Resuscitation Images in emergency medicine Source Type: research

Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial
DiscussionAlthough the benefits of breathing and aerobic exercises have been extensively studied, the comparison between both has never been investigated. Furthermore, the findings of our results will allow us to understand its application and suitability to patients that will have more benefits for every intervention optimizing its effect.Trial registration:; Identifier: NCT02065258. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 17, 2014 Category: Respiratory Medicine Authors: Karen EvaristoMilene SaccomaniMilton MartinsAlberto CukierRafael StelmachMarcos RodriguesDanilo SantaellaCelso Carvalho Source Type: research

Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia, May 2014
Conclusions: This epidemiological study revealed the complexity of MERS-CoV outbreak investigations with multiple potential exposures to MERS-CoV reported such as healthcare visits, camel exposure, and exposure to untreated food products. Exposure to MERS-CoV during a hospital visit is considered a likely source of infection for Case 1 but not for Case 2. For Case 2, the most likely source could not be determined. Exposure to MERS-CoV via direct contact with animals or dairy products seems unlikely for the two Dutch cases. Furthermore, exposure to a common but still unidentified source cannot be ruled out. More comprehensi...
Source: Emerging Themes in Epidemiology - October 17, 2014 Category: Epidemiology Authors: Ewout FanoyMarianne van der SandeMarleen Kraaij-DirkzwagerKees DirksenMarcel JongesWim van der HoekMarion KoopmansDouwe van der WerfGerard SonderCharlie van der WeijdenJet van der HeuvelLuc GelinckJolande BouwhuisArianne van Gageldonk-LafeberMERS-CoV outb Source Type: research

The Influence of Parenting on Early Childhood Health and Health Care Utilization
Conclusions This study highlights the importance of considering parenting practices when examining variations in early childhood health and health care, and the relevance of parental behavior in designing interventions for high-risk populations. (Source: Journal of Pediatric Psychology)
Source: Journal of Pediatric Psychology - October 17, 2014 Category: Pediatrics Authors: Serbin, L. A., Hubert, M., Hastings, P. D., Stack, D. M., Schwartzman, A. E. Tags: Regular Articles Source Type: research

Contemporary economic and clinical evaluations of endovascular repair for intact descending thoracic aortic aneurysms.
CONCLUSIONS: This study supports satisfying immediate clinical outcomes for TEVAR and TEVAR + surgical infrarenal procedures. Although limited by a small population size and difficulties in economic comparisons, this study presents the real world social and economic cost scenario for both elective TEVAR and TEVAR hybrid treatment of DTAA of both the in--hospital and at mid term follow--up periods. PMID: 25323106 [PubMed - as supplied by publisher] (Source: The Journal of Cardiovascular Surgery)
Source: The Journal of Cardiovascular Surgery - October 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Coppi G, Chester J, Gennai S, Silingardi R, Marcheselli L, Brunetti M Tags: J Cardiovasc Surg (Torino) Source Type: research

Does a non-invasive hemoglobin monitor correlate with a venous blood sample in the acutely ill?
Abstract Non-invasive hemoglobin measuring technology has potential for rapid, portable, and accurate way of providing identification of blood loss or anemia. Our objective is to determine if this technology is reliable in critically ill patients presenting to the Emergency Department. Prospective cross-sectional observational study was done at an urban level-one trauma center, 135 subjects were conveniently sampled, suspected of having active bleeding, sepsis, or other critically ill condition. Non-invasive measurements with Masimo (Irvine, CA, USA) Radical-7 and Rad-57 hemoglobin monitors were compared with the ...
Source: Internal and Emergency Medicine - October 17, 2014 Category: Emergency Medicine Source Type: research

Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats.
Conclusions: C1 cell stimulation reproduces most effects of acute hypoxia, specifically cardiorespiratory stimulation, sighs and arousal. C1 cell activation likely contributes to the sleep disruption and adverse autonomic consequences of sleep apnea. During hypoxia (awake) or REM sleep, C1 cell stimulation increases BP but no longer stimulates breathing. PMID: 25325789 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 17, 2014 Category: Respiratory Medicine Authors: Burke PG, Abbott SB, Coates MB, Viar KE, Stornetta RL, Guyenet PG Tags: Am J Respir Crit Care Med Source Type: research

Successful ultrasound imaging of pulmonary sub-pleural hamartoma
Abstract Pulmonary hamartoma, a common benign tumor of the lung, often presents as a solitary nodule on the peripheral lung, and is mainly composed of bronchial mucosa epithelial cells, chondrocytes, and adipose cells. Here, we report the case of a 42-year-old female who had a lung nodule that appeared as a homogeneous high-density shadow of a peripheral localization on chest computed tomography scan. For further evaluation, transthoracic ultrasonography examination was performed, which revealed a round, heterogenous, hypoechoic mass attached to the visceral pleura and showing obvious respiratory motions on the re...
Source: Journal of Medical Ultrasonics - October 17, 2014 Category: Radiology Source Type: research

Higher Levels of Spontaneous Breathing Reduce Lung Injury in Experimental Moderate Acute Respiratory Distress Syndrome*
Conclusions: In this model of moderate acute respiratory distress syndrome in pigs, biphasic positive airway pressure/airway pressure release ventilation with levels of spontaneous breath higher than usually seen in clinical practice, that is, more than 30% of total minute ventilation, reduced lung injury with improved respiratory function, as compared with protective controlled mechanical ventilation. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Ventilation Strategy for Acute Respiratory Distress Syndrome: Diaphragm at Rest or at Work?*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Editorials Source Type: research

The Burden of Influenza-Associated Critical Illness Hospitalizations*
Conclusions: Extrapolating our data to the 2010 U.S. population, we estimate that about 28,000 adults are hospitalized for influenza-associated critical illness annually. Influenza in many of these critically ill patients may be undiagnosed. Critical care physicians should have a high index of suspicion for influenza in the ICU, particularly when influenza is known to be circulating in their communities. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Simplified Severe Sepsis Protocol: A Randomized Controlled Trial of Modified Early Goal–Directed Therapy in Zambia*
Conclusion: Factors other than tissue hypoperfusion probably account for much of the end-organ dysfunction in African patients with severe sepsis. Studies of fluid-based interventions should utilize inclusion criteria to accurately capture patients with hypovolemia and tissue hypoperfusion who are most likely to benefit from fluids. Exclusion of patients with severe respiratory distress should be considered when ventilatory support is not readily available. (Source: Critical Care Medicine)
Source: Critical Care Medicine - October 16, 2014 Category: Emergency Medicine Tags: Feature Articles Source Type: research

Regular change in spontaneous preparative behaviour on intra-abdominal pressure and breathing during dynamic lifting
Conclusions Preparative pre-lifting behaviours alter IAP and breathing and are co-ordinated by the lifting load magnitude. These behaviours appear to be functionally important for dynamic lifting. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - October 16, 2014 Category: Physiology Source Type: research

Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients
Conclusion We found that BP change after a single night of CPAP largely depends upon comorbidity. Comorbidity likely contributes to phenotypic variability in OSAS population. BP might qualify as a surrogate index of the response to and, later, compliance with CPAP. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2014 Category: Respiratory Medicine Source Type: research

Impact of Functional Endoscopic Sinus Surgery on the Pulmonary Function of Patients with Chronic Rhinosinusitis: A Prospective Study
Abstract The study was conducted between September 2007 and March 2009 at Maulana Azad Medical College to compare the pulmonary function of patients with chronic rhinosinusitis presurgically and postsurgically. Thirty patients between 18 and 55 years of age with no prior history of respiratory illness were selected and pulmonary function test was conducted pre and post surgically. There was a significant difference between the pre and postoperative FEV1 and FEV1/FVC with the reading taken at 1 and 3 months post-surgically. The improvement in the PFT values signifies a decrease in the bronchial hyperresponsivene...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - October 16, 2014 Category: ENT & OMF Source Type: research

Expression and Regulation of Interleukin-37 in Pathogenesis of Nasal Polyps
This study is aimed to investigate the expression and regulation of IL-37 in patients with nasal polyps (NPs). Twenty-five patients with NPs and sixteen normal controls were included, and IL-37 production was determined by immunohistochemistry and enzyme-linked immuno sorbent assay, respectively. The relationship between IL-37 expression and Th1/Th2 cytokines was also evaluated. Besides, the effect of IL-37 on dispersed nasal polyp cells (DNPCs) was investigated. We observed significantly decreased IL-37 mRNA and protein levels expression in NPs compared with normal control. IL-37 was found negatively with Th2 cytokines an...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - October 16, 2014 Category: ENT & OMF Source Type: research

Milk production, intake, digestion, blood parameters, and ingestive behavior of cows supplemented with by-products from the biodiesel industry
This study aimed to evaluate the intake, digestion, blood parameters, and feeding behavior of crossbred dairy cows (Holstein × Gir) managed on Panicum maximum Jacq. cv. Tanzania-1 and provided supplementation with groundnut cake, sunflower cake, or palm kernel cake (to replace soybean meal). Sixteen cows were randomly assigned in a Latin square design with four treatments and four experimental periods. The consumption of nutrients from the pasture did not vary between experimental treatments. Cows receiving the palm kernel cake supplement had a reduced crude protein, non-fibrous carbohydrate, and total digestible nutr...
Source: Tropical Animal Health and Production - October 16, 2014 Category: Veterinary Research Source Type: research

Sojourn in excessively high oxygen saturation ranges in individual very low birth weight neonates
ConclusionMeasures to improve compliance with targeted SpO2 ranges should be applied universally although further improvement may be achieved by specifically targeting babies receiving supplemental oxygen via nasal cannula.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - October 16, 2014 Category: Pediatrics Authors: Jenda Arawiran, JeanneMarie Curry, Lorna Welde, Gad Alpan Tags: Regular Article Source Type: research

Validation of prediction models based on lasso regression with multiply imputed data
Conclusion: Performance of prognostic models constructed using the lasso technique can be optimistic as well. Results of the internal validation are sensitive to how bootstrap resampling is performed. (Source: BMC Medical Research Methodology)
Source: BMC Medical Research Methodology - October 16, 2014 Category: Research Authors: Jammbe MusoroAeilko ZwindermanMilo PuhanGerben ter RietRonald Geskus Source Type: research

Effect of acute sleep deprivation on heart rate recovery in healthy young adults
Conclusion Our findings suggest that SD blunts cardiovascular autonomic response, and consequences of this relation might be more pronounced in subjects who are exposed to sleeplessness regularly or in subjects with baseline cardiovascular disease. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 16, 2014 Category: Respiratory Medicine Source Type: research

An Unusual Cause of Tree-in-Bud Pattern: Pulmonary Intravascular Tumor Embolism Caused by Chondrosarcoma
We report the case of a 45-year-old man who initially presented with chondrosarcoma of the left femur that was treated surgically. Follow-up chest computed tomography (CT) performed 3 years later showed multiple small nodules with a tree-in-bud branching pattern and larger elongated opacities with beaded contours. These findings raised the suspicion of intravascular tumor embolism. Pulmonary CT angiography demonstrated intravascular thrombosis and dilated and beaded peripheral pulmonary arteries. The tumoral origin of the thrombus was confirmed by lung biopsy. (Source: Lung)
Source: Lung - October 16, 2014 Category: Respiratory Medicine Source Type: research

Safety and Long-Term Efficacy of Transition from Sildenafil to Tadalafil due to Side Effects in Patients with Pulmonary Arterial Hypertension
Conclusions The observations of this study indicate that a transition of sildenafil to tadalafil in case of intolerable side effects is a reasonable therapy option in about 50 % of the patients. These results should be verified by a larger prospective study. (Source: Lung)
Source: Lung - October 16, 2014 Category: Respiratory Medicine Source Type: research

Diagnosis of Latent Tuberculosis Infection with T-SPOT ® . TB in a Predominantly Immigrant Population with Rheumatologic Disorders
Conclusions TST+ and TSPOT+ results predict risk factors associated with LTBI independent of immunosuppressive IMT. Some TST+/TSPOT− results were unlikely to be false-negatives. The combined use of TST and TSPOT appears to be a reasonable diagnostic strategy to evaluate for LTBI in this population. (Source: Lung)
Source: Lung - October 16, 2014 Category: Respiratory Medicine Source Type: research

Alterations of insulin-like growth factor-1 receptor gene copy number and protein expression are common in non-small cell lung cancer
Conclusions High IGF1R gene copy number and protein overexpression are frequent in NSCLC, particularly in SCCs, but they are not prognostically relevant. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - October 16, 2014 Category: Pathology Authors: Tran, T. N., Selinger, C. I., Yu, B., Ng, C. C., Kohonen-Corish, M. R. J., McCaughan, B., Kennedy, C., O'Toole, S. A., Cooper, W. A. Tags: Molecular genetics, Immunology (including allergy), Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research

Therapeutic effects of amniotic fluid-derived mesenchymal stromal cells on lung injury in rats with emphysema
Conclusions: rAFMSCs might differentiate into AECII-like cells or induce local regeneration of the lung alveolar epithelium in vivo after transplantation and thus could be used in COPD treatment and lung regenerative therapy. (Source: Respiratory Research)
Source: Respiratory Research - October 16, 2014 Category: Respiratory Medicine Authors: Yaqing LiChao GuWulin XuJianping YanYingjie XiaYingyu MaChun ChenXujun HeHouquan Tao Source Type: research

Post-transcriptional Silencing of the COX Assembly Factor SURF1 [Molecular Bases of Disease]
Leigh Syndrome (LS) is the most common early-onset, progressive mitochondrial encephalopathy usually leading to early death. The single most prevalent cause of LS is occurrence of mutations in the SURF1 gene, and LSSurf1 patients show a ubiquitous and specific decrease in the activity of mitochondrial respiratory chain complex IV (cytochrome c oxidase, COX). SURF1 encodes an inner membrane mitochondrial protein involved in COX assembly. We established a Drosophila melanogaster model of LS based on the post-transcriptional silencing of CG9943, the Drosophila homolog of SURF1. Knockdown of Surf1 was induced ubiquitously in l...
Source: Journal of Biological Chemistry - October 16, 2014 Category: Chemistry Authors: Da–Re, C., von Stockum, S., Biscontin, A., Millino, C., Cisotto, P., Zordan, M. A., Zeviani, M., Bernardi, P., De Pitta, C., Costa, R. Tags: Bioenergetics Source Type: research

Burkholderia insulsa sp. nov., a facultatively chemolithotrophic bacterium isolated from an arsenic-rich shallow marine hydrothermal system.
Abstract Enrichment cultures inoculated with hydrothermally influenced nearshore sediment from Papua New Guinea led to the isolation of an arsenic-tolerant, acidophilic, facultatively aerobic bacterial strain named PNG-April(T). Cells of this strain were Gram-negative, rod-shaped, motile and did not form spores. Strain PNG-April(T) grew at temperatures between 4 °C and 40 °C (optimum 30 - 37 °C), at pH between 3.5 and 8.3 (optimum 5 - 6) and up to 2.7 % NaCl (optimum 0 - 1.0 %). Both arsenate and arsenite were tolerated up to concentrations of at least 0.5 mM. Metabolism in strain PNG-April(T) was strictly respi...
Source: International Journal of Systematic and Evolutionary Microbiology - October 16, 2014 Category: Microbiology Authors: Rusch A, Islam S, Savalia P, Amend JP Tags: Int J Syst Evol Microbiol Source Type: research

DosS is Required for the Complete Virulence of Mycobacterium tuberculosis in Mice with Classical Granulomatous Lesions.
Conclusions: DosS, but not DosR and DosT, is required by Mtb to survive in C3HeB/FeJ mice. The attenuation of Δ-dosS is not due to its inability to induce the DosR regulon, nor is it a result of the accumulation of hypoxia. That the in-vivo growth restriction of Δ-dosS could be mimicked ex-vivo suggested sensitivity to macrophage oxidative burst. Anoxic caseous centers within TB lesions eventually progress to cavities. Our results provide greater insight into the molecular mechanisms of Mtb persistence within host lungs. PMID: 25322074 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell ...
Source: American Journal of Respiratory Cell and Molecular Biology - October 16, 2014 Category: Molecular Biology Authors: Gautam US, McGillivray A, Mehra S, Didier PJ, Midkiff CC, Kissee RS, Golden NA, Alvarez X, Niu T, Rengarajan J, Sherman DR, Kaushal D Tags: Am J Respir Cell Mol Biol Source Type: research

mRNA Expression Levels of PGC-1α in a Transgenic and a Toxin Model of Huntington's Disease.
In this study, we examined the expression levels of FL-PGC-1α and N-truncated PGC-1α (NT-PGC-1α), a shorter but functionally active splice variant of PGC-1α protein, in N171-82Q transgenic and 3-nitropropionic acid-induced murine model of Huntington's disease (HD). The expression levels were determined by RT-PCR in three brain areas (striatum, cortex, and cerebellum) in three age groups (8, 12, and 16 weeks). Besides recapitulating prior findings that NT-PGC-1α is preferentially increased in 16 weeks of age in transgenic HD animals, we detected age-dependent alterations in both models, including a cerebellum-predomi...
Source: Cellular and Molecular Neurobiology - October 16, 2014 Category: Cytology Authors: Török R, Kónya JA, Zádori D, Veres G, Szalárdy L, Vécsei L, Klivényi P Tags: Cell Mol Neurobiol Source Type: research

Autonomic Arousal During Actigraphically Estimated Waking and Sleep in Male Veterans With PTSD
Physiological hyperarousal is manifested acutely by increased heart rate, decreased respiratory sinus arrhythmia, and increased skin conductance level and variability. Yet it is uncertain to what extent such activation occurs with the symptomatic hyperarousal of posttraumatic stress disorder (PTSD). We compared 56 male veterans with current PTSD to 54 males who never had PTSD. Subjects wore ambulatory devices that recorded electrocardiograms, finger skin conductance, and wrist movement while in their normal environments. Wrist movement was monitored to estimate sleep and waking periods. Heart rate, but not the other variab...
Source: Journal of Traumatic Stress - October 16, 2014 Category: Psychiatry & Psychology Authors: Franziska Bertram, Andrea L. Jamison, Cindie Slightam, Sunyoung Kim, Heidi L. Roth, Walton T. Roth Tags: Research Article Source Type: research

Clinical Predictors of the Respiratory Arousal Threshold in Patients with Obstructive Sleep Apnea.
Conclusions: Our results demonstrate that individuals with a low ArTH can be identified from standard, clinically available variables. This finding could facilitate larger interventional studies targeting the ArTH. PMID: 25321848 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 16, 2014 Category: Respiratory Medicine Authors: Edwards BA, Eckert DJ, McSharry DG, Sands SA, Desai A, Kehlmann G, Bakker JP, Genta PR, Owens RL, White DP, Wellman A, Malhotra A Tags: Am J Respir Crit Care Med Source Type: research

Patient-Centric Blood Pressure Targeted CPR Improves Survival from Cardiac Arrest.
Conclusions: Blood pressure targeted CPR improves 24-hour survival compared to optimal American Heart Association care in a porcine model of asphyxia-associated ventricular fibrillation cardiac arrest. PMID: 25321490 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 16, 2014 Category: Respiratory Medicine Authors: Sutton RM, Friess SH, Naim MY, Lampe JW, Bratinov G, Weiland Iii TR, Garuccio M, Nadkarni VM, Becker LB, Berg RA Tags: Am J Respir Crit Care Med Source Type: research