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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Prevalence and correlates of a ‘knee’ pattern on the maximal expiratory flow‐volume loop in young adults
ConclusionsA knee is a very common pattern on flow‐volume loop in young adults. In accordance with theoretical predictions, the prevalence of the knee declines with age, but it is more likely to persist in women. It is associated with less airflow obstruction and is less common in people with asthma. (Source: Respirology)
Source: Respirology - July 24, 2014 Category: Respiratory Medicine Authors: Hayden H. Shin, Malcolm R. Sears, Robert J. Hancox Tags: Original Article Source Type: research

Long-acting Bronchodilators and Arterial Stiffness in Patients with COPD: A Comparison of Fluticasone Furoate/Vilanterol with Tiotropium.
Conclusion:No differences on aPWV were observed between FF/VI and TIO. However, further studies with a placebo arm are required to establish definitively whether long-acting bronchodilators lower aPWV. Both treatments demonstrated an acceptable tolerability profile. Clinical Trial Investigation:GlaxoSmithKline HZC115247; clinicaltrials.gov identifier: NCT01395888; http://clinicaltrials.gov/ct2/show/NCT01395888. Background: Increased arterial stiffness as measured by aortic pulse wave velocity (aPWV) predicts cardiovascular events and mortality, and is elevated in chronic obstructive pulmonary disease (COPD) patients. P...
Source: Chest - July 24, 2014 Category: Respiratory Medicine Authors: Pepin JL, Cockcroft JR, Midwinter D, Sharma S, Rubin DB, Andreas S Tags: Chest Source Type: research

Total and state-specific medical and absenteeism costs of chronic obstructive pulmonary disease among adults aged ≥18 years in the United States for 2010 and projections through 2020.
Conclusion: Costs attributable to COPD and its sequelae are substantial and are projected to increase through 2020. Evidence-based interventions that prevent tobacco use and reduce clinical complications of COPD may result in potential decreased COPD-attributable costs. PMID: 25058738 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - July 24, 2014 Category: Respiratory Medicine Authors: Ford ES, Murphy LB, Khavjou O, Giles WH, Holt JB, Croft JB Tags: Chest Source Type: research

Treatment of Alveolar-Pleural fistula with endobronchial application of synthetic hydrogel (CoSeal).
Conclusion:Bronchoscopic administration of a synthetic hydrogel is an effective, nonsurgical, minimally invasive intervention for patients with persistent pulmonary air leaks secondary to alveolar-pleural fistula. Background: Alveolar-pleural fistula with persistent air leak is a common problem causing significant morbidity, prolonged hospital stay and increased health care costs. When conventional therapy fails, an alternative to prolonged chest tube drainage or surgery is needed. New bronchoscopic techniques have been developed to close the air leak by reducing the flow of air through the leak. The objective of this ...
Source: Chest - July 24, 2014 Category: Respiratory Medicine Authors: Mehta HJ, Malhotra P, Begnaud A, Penley AM, Jantz MA Tags: Chest Source Type: research

Swallowing and breathing patterns during sleep in patients with obstructive sleep apnea.
CONCLUSIONS: Swallowing frequency during sleep can increase with increasing OSA severity in most OSA patients. These events are predominately associated with respiratory event-related arousals and are more frequent when preceded by oronasal breathing. The observed swallowing under high ventilatory needs may compromise the maintenance of the pharynx as a conduit for airflow in OSA patients. PMID: 25056664 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 24, 2014 Category: Sleep Medicine Authors: Yagi K, Lowe AA, Ayas NT, Fleetham JA, Almeida FR Tags: Sleep Breath Source Type: research

Multiscale fingerprinting of neuronal functional connectivity.
Abstract Current cellular-based connectomics approaches aim to delineate the functional or structural organizations of mammalian brain circuits through neuronal activity mapping and/or axonal tracing. To discern possible connectivity between functionally identified neurons in widely distributed brain circuits, reliable and efficient network-based approaches of cross-registering or cross-correlating such functional-structural data are essential. Here, a novel cross-correlation approach that exploits multiple timing-specific, response-specific, and cell-specific neuronal characteristics as coincident fingerprint mark...
Source: Brain Structure and Function - July 24, 2014 Category: Neuroscience Authors: Song G, Tin C, Poon CS Tags: Brain Struct Funct Source Type: research

Breathing-phase selective filtering of respiratory data improves analysis of dynamic respiratory mechanics.
CONCLUSIONS: The selective filtering of expiration data eliminates negative side-effects of cardiogenic oscillations thus leading to a significant improvement of the analysis of dynamic respiratory system mechanics. PMID: 25059258 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - July 24, 2014 Category: Medical Equipment Authors: Lozano-Zahonero S, Buehler S, Schumann S, Guttmann J Tags: Technol Health Care Source Type: research

The Evolution of Spacers and Valved Holding Chambers
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. S1: S-4-S-23. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 23, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Lung Deposition of 99mTc-Radiolabeled Albuterol Delivered through a Pressurized Metered Dose Inhaler and Spacer with Facemask or Mouthpiece in Children with Asthma
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. S1: S-63-S-75. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 23, 2014 Category: Respiratory Medicine Tags: article Source Type: research

In Vitro Characterization of the OptiChamber Diamond Valved Holding Chamber
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. S1: S-24-S-36. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 23, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Focus on pMDI and VHC; Past, Present, Future!
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. S1: S-1-S-3. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 23, 2014 Category: Respiratory Medicine Tags: article Source Type: research

An Instrumented Valved Holding Chamber with Facemask to Measure Application Forces and Flow in Young Asthmatic Children
Journal of Aerosol Medicine and Pulmonary Drug Delivery Aug 2014, Vol. 27, No. S1: S-55-S-62. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 23, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Estimating the Time Interval Between Exposure to the World Trade Center Disaster and Incident Diagnoses of Obstructive Airway Disease
Respiratory disorders are associated with occupational and environmental exposures. The latency period between exposure and disease onset remains uncertain. The World Trade Center (WTC) disaster presents a unique opportunity to describe the latency period for obstructive airway disease (OAD) diagnoses. This prospective cohort study of New York City firefighters compared the timing and incidence of physician-diagnosed OAD relative to WTC exposure. Exposure was categorized by WTC arrival time as high (on the morning of September 11, 2001), moderate (after noon on September 11, 2001, or on September 12, 2001), or low (during ...
Source: American Journal of Epidemiology - July 23, 2014 Category: Epidemiology Authors: Glaser, M. S., Webber, M. P., Zeig-Owens, R., Weakley, J., Liu, X., Ye, F., Cohen, H. W., Aldrich, T. K., Kelly, K. J., Nolan, A., Weiden, M. D., Prezant, D. J., Hall, C. B. Tags: RESEARCH-ARTICLE Source Type: research

Current perspectives in transfusion‐transmitted infectious diseases: emerging and re‐emerging infections
ConclusionsThe process and final product (toolkit) including methods to monitor EID agent emergence, identification/recognition of a transfusion‐transmission threat, methods for quantitative risk assessments, and the appropriate management of such threats should be considered for implementation by all blood systems. (Source: ISBT Science Series)
Source: ISBT Science Series - July 23, 2014 Category: Hematology Authors: S. L. Stramer Tags: State of the Art Source Type: research

Emerging and imported infections in the region – what's bothering us today?
An emerging infection is defined as one that has appeared in a population for the first time, or that may have existed previously but is rapidly increasing in incidence or geographic range. The Asia Pacific region, with 30% of global population, has a reputation as a hot spot for emerging infections. The emergence of severe acute respiratory syndrome exactly 10 years ago dramatically transformed individual and national awareness and capabilities for identifying and responding to regional emerging infectious threats. The impact of emerging infections on the blood supply may be direct through the potential for transmission ...
Source: ISBT Science Series - July 23, 2014 Category: Hematology Authors: D. Teo Tags: State of the Art Source Type: research

A mitochondrial origin for frontotemporal dementia and amyotrophic lateral sclerosis through CHCHD10 involvement
We report a large family with a late-onset phenotype including motor neuron disease, cognitive decline resembling frontotemporal dementia, cerebellar ataxia and myopathy. In all patients, muscle biopsy showed ragged-red and cytochrome c oxidase-negative fibres with combined respiratory chain deficiency and abnormal assembly of complex V. The multiple mitochondrial DNA deletions found in skeletal muscle revealed a mitochondrial DNA instability disorder. Patient fibroblasts present with respiratory chain deficiency, mitochondrial ultrastructural alterations and fragmentation of the mitochondrial network. Interestingly, expre...
Source: Brain - July 23, 2014 Category: Neurology Authors: Bannwarth, S., Ait-El-Mkadem, S., Chaussenot, A., Genin, E. C., Lacas-Gervais, S., Fragaki, K., Berg-Alonso, L., Kageyama, Y., Serre, V., Moore, D. G., Verschueren, A., Rouzier, C., Le Ber, I., Auge, G., Cochaud, C., Lespinasse, F., N'Guyen, K., de Septen Tags: Original Articles Source Type: research

Concentrated ascites re‐infusion therapy for pseudo‐Meigs' syndrome complicated by massive ascites in large pedunculated uterine leiomyoma
Abstract Pseudo‐Meigs' syndrome accompanied by massive ascites in uterine leiomyoma is rare. We encountered a rare case of a 37‐year‐old, nulliparous woman with a lower abdominal tumor and severe abdominal distention due to massive ascites. Serum cancer antigen 125 and vascular endothelial growth factor levels were elevated to 1007.9 U/mL and 103 pg/mL, respectively. She was tentatively diagnosed with ovarian cancer. Emergency concentrated ascites re‐infusion therapy was performed to improve dyspnea, abdominal pain, and her preoperative respiratory condition. Concentrated ascites re‐infusion therapy eliminate...
Source: Journal of Obstetrics and Gynaecology Research - July 23, 2014 Category: OBGYN Authors: Yukie Yonehara, Shintaro Yanazume, Masaki Kamio, Shinichi Togami, Takashi Tasaki, Tsutomu Douchi Tags: Case Report Source Type: research

Act now to avoid winter deaths.
Authors: Abstract Essential facts [Figure: see text] Cold weather has a direct effect on the number of people experiencing heart attacks, stroke, respiratory disease and flu. According to the Office for National Statistics, an estimated 31,100 excess winter deaths occurred in England and Wales in 2012/13 - a rise of 29 per cent compared with the previous year. Of these people, 25,600 were aged 75 or above. PMID: 25052647 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - July 23, 2014 Category: Nursing Tags: Nurs Stand Source Type: research

Pneumonia, thrombosis and vascular disease
SummaryAn enhanced risk of cardiovascular mortality has been observed after pneumonia. Epidemiological studies have shown that respiratory tract infections are associated with an increased risk of thrombotic‐related vascular disease such as myocardial infarction, ischemic stroke and venous thrombosis. Myocardial infarction and stroke have been detected essentially in the early phase of the disease (i.e. within 48 h from hospital admission), with an incidence ranging from as low as 1% to as high as 11%. Age, previous cardiovascular events and high pneumonia severity index were independent predictors of myocardial infarct...
Source: Journal of Thrombosis and Haemostasis - July 23, 2014 Category: Hematology Authors: F. Violi, R. Cangemi, C. Calvieri Tags: Review Article Source Type: research

Is Previous Respiratory Disease a Risk Factor for Lung Cancer?
Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer. PMID: 25054566 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2014 Category: Respiratory Medicine Authors: Denholm R, Schüz J, Straif K, Stücker I, Jöckel KH, Brenner DR, De Matteis S, Boffetta P, Guida F, Brüske I, Wichmann HE, Landi MT, Caporaso N, Siemiatycki J, Ahrens W, Pohlabeln H, Zaridze D, Field JK, McLaughlin J, Demers P, Szeszenia-Dabrowska N, L Tags: Am J Respir Crit Care Med Source Type: research

Integrative 'Omic Analysis of Experimental Bacteremia Identifies a Metabolic Signature that Distinguishes Human Sepsis from SIRS.
Conclusion: A model of sepsis based on reciprocal metabolomic and transcriptomic data was developed in primates and validated in two human patient cohorts. It is anticipated that the identified parameters will facilitate early diagnosis and management of sepsis. PMID: 25054455 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2014 Category: Respiratory Medicine Authors: Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler Jr VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA Tags: Am J Respir Crit Care Med Source Type: research

Ultrastructure of Human Tracheal Smooth Muscle from Asthmatic and Non-asthmatic Subjects: Standardized Methods for Comparison.
Abstract A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyperresponsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically different from non-asthmatic ASM in terms of subcellular structure or mechanical function. The present study is the first to systematically quantify, using electron microscopy, the ultrastructure of tracheal SM from asthmatic and non-asthmatic subjects. Methodological details concerning tissue sample preparation, ul...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Syyong HT, Pascoe CD, Zhang J, Arsenault BA, Solomon D, Elliott WM, Hackett TL, Walker DC, Paré PD, Seow CY Tags: Am J Respir Cell Mol Biol Source Type: research

Role of miR-150 and Glycoprotein Non-metastatic Melanoma Protein B in Angiogenesis During Hyperoxia-induced Neonatal Lung Injury.
Conclusions. GPNMB plays an important role in angiogenesis during hyperoxia-injury. Treatment with GPNMB may offer a novel therapeutic approach in reducing pathologic complications in bronchopulmonary dysplasia. PMID: 25054912 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, Liu L Tags: Am J Respir Cell Mol Biol Source Type: research

Interaction With Epithelial Cells Modifies Airway Macrophage Response to Ozone.
Abstract The initial innate immune response to ozone (O3) in the lung is orchestrated by structural cells, such as epithelial cells, and resident immune cells, such as airway macrophages (Mac). We developed an epithelial cell-Mac co-culture model to investigate how epithelial cell-derived signals affect Mac response to O3. Mac from the bronchoalveolar lavage (BAL) of healthy volunteers were co-cultured with the human bronchial (16HBE) or alveolar (A549) epithelial cell lines. Co-cultures, Mac monocultures, and epithelial cell monocultures were exposed to O3 or air and Mac immunophenotype, phagocytosis, and cytotoxi...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Bauer RN, Müller L, Brighton LE, Duncan KE, Jaspers I Tags: Am J Respir Cell Mol Biol Source Type: research

Pigment Epithelium-derived Factor Mediates Impaired Lung Vascular Development in Neonatal Hyperoxia.
Abstract BPD is a chronic lung disease of preterm infants characterized by arrested microvascularization and alveolarization. Studies show the importance of pro-angiogenic factors for alveolarization, but the importance of anti-angiogenic factors is unknown. We proposed that hyperoxia increases the potent angiostatin Pigment Epithelium-derived Factor (PEDF) in neonatal lungs, inhibiting alveolarization and microvascularization. Wild type (WT) and PEDF (-/-) mice were exposed to room air (RA) or 0.9 FiO2 from postnatal day 5 to 13. PEDF protein was increased in hyperoxia compared to RA-exposed lungs (P<0.05). In ...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Chetty A, Bennett M, Dang L, Nakamura D, Cao GJ, Mujahid S, Volpe M, Herman I, Becerra SP, Nielsen HC Tags: Am J Respir Cell Mol Biol Source Type: research

Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate.
Abstract We have previously reported that nickel acetate (Ni(2+)), a well-known human carcinogenic agents, differentially affected apoptosis in two different airway epithelial cell lines derived from the human respiratory tract (A549 and Beas-2B, respectively), suggesting a potential involvement of epidermal growth factor receptor (EGFR)/Neu receptors in mediating this effect. Since ErbBs are closely associated to Mucin 1 (MUC1), a glycoprotein component of airway mucus that is overexpressed in lung tumors, we have investigated the role of this signaling system in the survival response of airway epithelial cells ag...
Source: Biometals - July 23, 2014 Category: Biochemistry Authors: Castorina A, Giunta S Tags: Biometals Source Type: research

Two-week Normobaric Intermittent-Hypoxia Exposures Enhance Oxyhemoglobin Equilibrium and Cardiac Responses during Hypoxemia.
Abstract Intermittent-hypoxia (IH) is extensively applied to challenge cardiovascular and respiratory function, and to induce physiological acclimatization. The purpose of this study was to test the hypothesis that oxyhemoglobin equilibrium and tachycardiac responses during hypoxemia were enhanced after 14-day IH exposures. Normobaric-poikilocapnic hypoxia was induced with inhalation of 10% O2 for 5-6 min interspersed with 4-min recovery on eight non-smokers. Heart rate (HR), arterial O2 saturation (SaO2) and end-tidal O2 (PETO2) were continuously monitored during cyclic normoxia and hypoxia. These variables were c...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - July 23, 2014 Category: Physiology Authors: Zhang P, Downey HF, Chen S, Shi X Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Improved growth performance by a new modified live porcine reproductive and respiratory syndrome vaccine in pigs under field conditions.
Abstract The growth performance of a new modified live porcine reproductive and respiratory syndrome (PRRS) vaccine was evaluated under field conditions for registration with the government as guided by the Republic of Korea's Animal and Plant Quarantine Agency. Three farms were selected based on their history of PRRS-associated respiratory diseases. On each farm, a total of 45 3-week-old pigs were randomly allocated to one of two treatment groups, (i) vaccinated (n = 25) or (ii) control (n = 20) animals. A new modified live PRRSV vaccine increased market weight by 1.26 kilograms/pig (104.71 kilograms vs. 103.45 ki...
Source: Clinical and Vaccine Immunology - July 23, 2014 Category: Allergy & Immunology Authors: Park C, Seo HW, Kang I, Jeong J, Choi K, Chae C Tags: Clin Vaccine Immunol Source Type: research

Targeting of High Peak Respiratory Exchange Ratio Is Safe and Enhances the Prognostic Power of Peak Oxygen Uptake for Heart Failure Patients.
Conclusions:In CPX targeting pRER >1.20 for HF patients, peak V̇O2is the most powerful among well-known predictors, without an increased risk of exercise-related events. These findings advocate a high target pRER in CPX even in advanced HF. PMID: 25056425 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - July 23, 2014 Category: Cardiology Authors: Nakanishi M, Takaki H, Kumasaka R, Arakawa T, Noguchi T, Sugimachi M, Goto Y Tags: Circ J Source Type: research

Analysis of Three-Dimensional Aerosol Deposition in Pharmacologically Relevant Terms: Beyond Black or White ROIs
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

In Vitro Performance of Spacers for Aerosol Delivery during Adult Mechanical Ventilation
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

The Effect of Beclometasone Dipropionate/Formoterol Extra-Fine Fixed Combination on the Peripheral Airway Inflammation in Controlled Asthma
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Prospective External Validation of a Predictive Score for Postoperative Pulmonary Complications
Background: No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe). Methods: Sixty-three centers recruited 5,859 surgical patients receiving general, neuraxial, or plexus block anesthesia. The Assess Respiratory Risk in Surgical Patients in Catalonia factors (age, preoperative arterial oxygen saturation in air, acute respiratory i...
Source: Anesthesiology - July 22, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Clinical Science Source Type: research

Thoraco‐abdominal asymmetry and asynchrony in congenital diaphragmatic hernia
ConclusionsIn overall CDH patients a reduced action of the treated (left) hemi‐diaphragm is evident. In patients treated by primary suture, a compensatory action of the right side allows to reach a normal total diaphragmatic displacement and a proper contribution of the whole diaphragm to tidal volume. In patients treated by diaphragmatic patch, instead, thoraco‐abdominal asynchronies are prevented. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 22, 2014 Category: Respiratory Medicine Authors: Marianna Laviola, Andrea Zanini, Rita Priori, Francesco Macchini, Ernesto Leva, Maurizio Torricelli, Clara Ceruti, Andrea Aliverti Tags: Original Article: Other Source Type: research

Illness perception in people with chronic obstructive pulmonary disease
Illness perception (IP) concerns how patients evaluate living with a disease. To get a broader understanding of IP in patients with chronic obstructive pulmonary disease (COPD), we investigated whether breathlessness is an important precursor of IP and whether IP in its turn is related to mental health, physical health and global quality of life (QOL). One hundred and fifty‐four patients with COPD participated in a cross‐sectional survey. Participants underwent pulmonary function testing, provided socio‐demographic and clinical information, and completed the following standardized instruments: Brief Illness Perceptio...
Source: Scandinavian Journal of Psychology - July 22, 2014 Category: Psychiatry & Psychology Authors: Christine Råheim Borge, Torbjørn Moum, Martha Puline Lein, Elise Lynn Austegard, Astrid Klopstad Wahl Tags: Health and Disability Source Type: research

Pierre Robin Sequence: A Perioperative Review.
Abstract The clinical triad of micrognathia (small mandible), glossoptosis (backward, downward displacement of the tongue), and airway obstruction defines the Pierre Robin sequence (PRS). Airway obstruction and respiratory distress are clinical hallmarks. Patients may present with stridor, retractions, and cyanosis. Severe obstruction results in feeding difficulty, reflux, and failure to thrive. Treatment options depend on the severity of airway obstruction and include prone positioning, nasopharyngeal airways, tongue lip adhesion, mandibular distraction osteogenesis, and tracheostomy. The neonate and infant with P...
Source: Anesthesia and Analgesia - July 22, 2014 Category: Anesthesiology Authors: Cladis F, Kumar A, Grunwaldt L, Otteson T, Ford M, Losee JE Tags: Anesth Analg Source Type: research

Ginseng Diminishes Lung Disease in Mice Immunized with Formalin-Inactivated Respiratory Syncytial Virus After Challenge by Modulating Host Immune Responses
Journal of Interferon & Cytokine Research , Vol. 0, No. 0. (Source: Journal of Interferon)
Source: Journal of Interferon - July 22, 2014 Category: Research Tags: article Source Type: research

80 Year Old Male: Fall
A previously well 80-year-old experienced a fall at his home where he lives alone. He was walking from the living room to the kitchen when suddenly he found himself on the ground, which he attributes to tripping on the runner rug in the hallway. “My son has been telling me to get rid of that thing for years but I don’t like getting the carpet dirty.” Unfortunately he injured his hip in the process and wasn’t able to get to the phone to call for assistance, spending two days on the floor until the Meals on Wheels volunteer came by. Skin is cool and dry and his mucous membranes are dry. He has severe ...
Source: EMS 12-Lead - July 22, 2014 Category: Cardiology Authors: Vince DiGiulio Tags: 12 lead ecg Arrhythmias Cases AV Block bifascicular block bradycardia Heart Block LAFB Mobitz II RBBB Syncope type II Source Type: research

[Comment] Challenges to global pandemic mortality estimation
In May 2012, we published estimates of global mortality associated with influenza A H1N1 pandemic 2009 (H1N1pdm09) virus infection during the first year of virus circulation in each country. In November, 2013, Simonsen and colleagues also presented estimates of global H1N1pdm09-associated mortality during April, 2009, to December, 2009. Although different methods were used, the two studies reached reassuringly similar conclusions. We estimated 201 000 respiratory deaths, and Simonsen and colleagues estimated 188 000 respiratory deaths; most estimated deaths in both studies were in people younger than 65 years; and in f...
Source: The Lancet Infectious Diseases - July 22, 2014 Category: Infectious Diseases Authors: Marc-Alain Widdowson, A Danielle Iuliano, Fatimah S Dawood Tags: Comment Source Type: research

Second-hand tobacco smoke and children
Cigarette smoke contains harmful chemicals with hazardous adverse effects on almost every organ in the body of smokers as well as of nonsmokers exposed to environmental tobacco smoke (ETS). There has been increasing interest in the effects of passive smoking on the health of children. In order to detect the magnitude of passive smoking in children, parental questionnaires, measuring nicotine and cotinine body levels, and evaluating expired carbon monoxide (CO) concentrations, have been used. Passive smoking causes respiratory illness, asthma, poor growth, neurological disorders, and coronary heart diseases. Herein, we focu...
Source: Toxicology and Industrial Health current issue - July 22, 2014 Category: Toxicology Authors: Al-Sayed, E. M., Ibrahim, K. S. Tags: Articles Source Type: research

A role for the mitochondrial-associated protein p32 in regulation of trophoblast proliferation
In this study, we sought to examine the expression and function of p32 in the human placenta. p32 was highly expressed in the syncytiotrophoblast, the underlying cytotrophoblast (CTB), the vascular endothelium and by a proportion of cells in the villous stroma in first trimester and term placenta. p32 mRNA and protein expression was significantly higher in the first trimester of pregnancy than at term, and expression in the trophoblast was significantly reduced in placentas from women with fetal growth restriction (FGR). Small interfering RNA (siRNA)-mediated knockdown of p32 in term placental explants significantly reduce...
Source: Molecular Human Reproduction - July 22, 2014 Category: Molecular Biology Authors: Matos, P., Horn, J. A., Beards, F., Lui, S., Desforges, M., Harris, L. K. Tags: Articles Source Type: research

IMRT sparing of normal tissues in locoregional treatment of breast cancer
Conclusion: IMRT-HT for locoregional breast radiation is very well tolerated with minimal acute or moderately-late side effects. Cardiac and respiratory tests did not show any strong evidence of significant treatment related abnormalities.Trial registration: clinicaltrials.gov: NCT00508352. (Source: Radiation Oncology)
Source: Radiation Oncology - July 22, 2014 Category: Cancer & Oncology Authors: Jean-Michel CaudrelierJoanne MengBernd EscheLaval GrimardTerrence RuddyKayvan Amjadi Source Type: research

Application of a Monte Carlo lung dosimetry code to the inhalation of thoron progeny
To determine radiation doses incurred by inhaled thoron progeny, the Monte Carlo radon progeny lung dosimetry code IDEAL-DOSE was adapted to the inhalation of thoron progenies, comprising the alpha-emitting nuclides 216Po, 212Bi and 212Po. Dose calculations for defined exposure conditions yielded a dose conversion coefficient (DCC) of 4.6 mSv WLM–1 or 94.2 nSv (Bq h m–3)–1 when compared with a DCC of 3.8 mSv WLM–1 if based on the International Commission on Radiological Protection Human Respiratory Tract Model. Bronchial doses were computed for different thoron progenies exposure conditions measured...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Hofmann, W., Winkler-HeiI, R., Truta, L. A., Tschiersch, J. Tags: Health effects of radon Source Type: research

Radon dose assessment in underground mines in Brazil
Underground miners are internally exposed to radon, thoron and their short-lived decay products during the mineral processing. There is also an external exposure due to the gamma emitters present in the rock and dust of the mine. However, the short-lived radon decay products are recognised as the main radiation health risk. When inhaled, they are deposited in the respiratory system and may cause lung cancer. To address this concern, concentration measurements of radon and its progeny were performed, the equilibrium factor was determined and the effective dose received was estimated in six Brazilian underground mines. The r...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Santos, T. O., Rocha, Z., Cruz, P., Gouvea, V. A., Siqueira, J. B., Oliveira, A. H. Tags: Health effects of radon Source Type: research

Calibration of CR-39-based thoron progeny device
This study deals with the calibration of the track detector measurement method suitable for measuring thoron progenies using different devices with measurement techniques capable of measuring several progenies (Pylon AB5 and WLx, Sarad EQF 3220). The calibration factor values related to the thoron progeny monitors, the measurement uncertainty, reproducibility and other parameters were found using the calibration chamber. In the future, the effects of the different parameters (aerosol distribution, etc.) will be determined. (Source: Radiation Protection Dosimetry)
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Fabian, F., Csordas, A., Shahrokhi, A., Somlai, J., Kovacs, T. Tags: Methods of measurement-devices, metrological aspects Source Type: research

Size distribution of radon decay products in the range 0.1-10 nm
Information about the size distribution of radioactive aerosols in nanometre range is essential for the purposes of air contamination monitoring, dose assessment to respiratory tract and planning of protective measures. The diffusion battery, which allows capturing particles in the size range of 0.1–10 nm, has developed. Interpreting data obtained from diffusion battery is very complex. The method of expectation maximisation by Maher and Laird was chosen for indirect inversion data. The experiments were performed in the box with equivalent equilibrium concentration of radon in the range of 7000–10 000 Bq m&ndas...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Zhukovsky, M., Rogozina, M., Suponkina, A. Tags: Methods of measurement-devices, metrological aspects Source Type: research

HrtBA and menaquinones control haem homeostasis in Lactococcus lactis
Summary Lactococcus lactis is a fermenting Gram‐positive bacterium widely used for production of dairy products. Lacking haem biosynthesis genes, L. lactis can still shift to an energetically favourable respiratory metabolism by activating a terminal cytochrome bd oxidase when haem is added to an aerated culture. Haem intracellular homeostasis is mediated by the hrtRBA operon encoding the conserved membrane HrtBA haem efflux permease and the unique intracellular haem sensor and regulator, HrtR. Here we report that membrane‐associated menaquinones (MK) favour the accumulation of reduced haem in membranes. An oxidative e...
Source: Molecular Microbiology - July 22, 2014 Category: Microbiology Authors: Laetitia Joubert, Aurélie Derré‐Bobillot, Philippe Gaudu, Alexandra Gruss, Delphine Lechardeur Tags: Research Article Source Type: research