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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

The respiratory health benefits of quitting cannabis use
Cannabis is the second most widely smoked substance besides tobacco. Moreover, its use in some societies has increased over the past several years [1], possibly due to changing perceptions regarding its potentially deleterious effects on health and its putative health benefits [2], as reflected by decriminalisation and legalisation for medicinal or recreational use by some regulatory authorities. A limited number of observational studies have examined the effects of cannabis on respiratory health [3–9]. These have nearly uniformly demonstrated an association between cannabis use and symptoms of chronic bronchitis [3&...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Tashkin, D. P. Tags: COPD and smoking Editorials Source Type: research

Animal fur and asthma: an indoor farmyard phenomenon?
The relationships between allergen exposure, sensitisation and the development of allergic disease have, since their first description, been complicated, often counterintuitive, and rarely straightforward. Ever since Charles Blackley put himself through a private medical education in order to study his own severe "summer catarrh", allergens and their human targets have been behaving oddly. Blackley [1] suggested a hypothesis (circa 1870s) that his summer catarrh or hay fever might be associated with exposure to seasonal grass pollens (the current belief at the time was that it was caused by increased temperatures in summer...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Crane, J. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy, Paediatric pulmonology Editorials Source Type: research

Defining airflow limitation and chronic obstructive pulmonary disease: the role of outcome studies
A guideline to the interpretation of pulmonary function tests, published 20 years ago, made a distinction between the related tasks of "(1) the classification of the derived values with respect to a reference population... and (2) the integration of the spirometric values into the diagnosis, therapy and prognosis for an individual patient." [1]. The first of these is very straightforward, when appropriate reference data are available, but the latter is difficult in the early stages of disease and will have a degree of uncertainty for any individual. Confusion arises when the distinction between these two aspects of in...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Culver, B. Tags: Lung structure and function Editorials Source Type: research

Cystic fibrosis in Europe: patients live longer but are we ready?
Having passed the 25th anniversary of discovering the cystic fibrosis transmembrane conductance regulator (CFTR) gene, let's take a look forward to the next 25 years. Newborn screening, animal models, biomarkers, innovative drugs (prototypical CFTR modulators), and advances in lung transplantation have moved the field forward, probably faster than for any other lung disease in recent years [1–5]. As a consequence, the mean survival of patients with cystic fibrosis (CF) is steadily increasing and now exceeds 40 years of age in most European countries [6, 7] and beyond [8]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Schwarz, C., Hartl, D. Tags: CF and non-CF bronchiectasis Editorials Source Type: research

Never too old: beneficial neurobehavioural effects of continuous positive airway pressure in the elderly
This month's issue of the European Respiratory Journal contains a report of a randomised controlled clinical trial for the treatment of obstructive sleep apnoea (OSA) using continuous positive airway pressure (CPAP) [1]. What makes this trial unique and distinguishes it from dozens of other such studies in the published literature is that all of the participants were elderly (≥70 years of age). (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Bliwise, D. L. Tags: Sleep medicine Editorials Source Type: research

Insights into idiopathic pulmonary fibrosis in the real world
Idiopathic pulmonary fibrosis (IPF) is a relentless fibrotic disorder leading to an irreversible damage of the lungs, chronic respiratory failure, and death after a median of 3 years following the diagnosis [1]. The landscape in IPF has recently been profoundly modified in a number of ways. The disease process, once considered as a chronic inflammation and treated with anti-inflammatory and immunosuppressive drugs, is now viewed as uncontrolled wound healing resulting from injury to the alveolar epithelium [2]. Epidemiological studies have showed that IPF is more common than previously appreciated in the elderly popul...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Cottin, V., Wuyts, W. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Targeted therapies: detrimental treatment for nonsmall cell lung cancer without driver mutations
The search for oncogenic driver mutations is currently a standard in the management of advanced nonsquamous nonsmall cell lung cancer (NSCLC) [1], at least for epidermal growth factor receptor (EGFR) activating mutations and anaplastic lymphoma kinase (ALK) rearrangement. At the beginning of the 21st century, two small orally available molecules with EGFR tyrosine kinase inhibitor (TKI) activity, erlotinib and gefitinib, have been developed and tested mainly in unselected Caucasian populations, concomitantly or sequentially with chemotherapy. Five randomised phase III trials did not demonstrate any supplemental activity by...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Berghmans, T., Meert, A.-P., Quoix, E. Tags: Lung cancer Editorials Source Type: research

The Transatlantic Trade and Investment Partnership: Trojan horse or positive force for health?
For centuries, Greek mythology strove to reflect human behaviour through its myths. One of the more well-known myths is that of the Trojan horse, a poisoned chalice offered to the Trojans in which the Greeks were hidden to invade the city, and which has come to symbolise human deceit. Today, this link between the myth and actual facts is in the limelight with respect to the Transatlantic Trade and Investment Partnership (TTIP), which is currently being negotiated between the European Union (EU) and the USA. Some see the EU citizens as the trapped Trojans and the EU and the USA leaders as the cunning Greeks. Roughly speakin...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Faure, M., Ward, B. Tags: European Lung Corner Source Type: research

From the Museum: the Art of Thinking. Squaring the circle.
(Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Kotsimbos, T. Tags: From the Museum Source Type: research

ESR/ERS white paper on lung cancer screening
Lung cancer is the most frequently fatal cancer, with poor survival once the disease is advanced. Annual low dose computed tomography has shown a survival benefit in screening individuals at high risk for lung cancer. Based on the available evidence, the European Society of Radiology and the European Respiratory Society recommend lung cancer screening in comprehensive, quality-assured, longitudinal programmes within a clinical trial or in routine clinical practice at certified multidisciplinary medical centres. Minimum requirements include: standardised operating procedures for low dose image acquisition, computer-assisted...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Kauczor, H.-U., Bonomo, L., Gaga, M., Nackaerts, K., Peled, N., Prokop, M., Remy-Jardin, M., von Stackelberg, O., Sculier, J.-P., on behalf of the European Society of Radiology (ESR) and the European Respiratory Society (ERS) Tags: Lung cancer Original Articles: ESR/ERS white paper Source Type: research

Combined endobronchial and oesophageal endosonography for the diagnosis and staging of lung cancer
(Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Vilmann, P., Clementsen, P. F., Colella, S., Siemsen, M., De Leyn, P., Dumonceau, J.-M., Herth, F. J., Larghi, A., Vazquez-Sequeiros, E., Hassan, C., Crombag, L., Korevaar, D. A., Konge, L., Annema, J. T. Tags: Lung cancer Original Articles: ESGE/ERS/ESTS guidelines Source Type: research

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As part of the July issue, the European Respiratory Journal presents the 55th in its series of podcasts, in which chief editor Marc Humbert discusses future trends in cystic fibrosis patient demographics with Prof. Pierre-Régis Burgel, Université Paris-Descartes, Paris, France. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Tags: Electronic Resources Source Type: research

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit
We describe the epidemiological links between smoking and pulmonary disorders, the evidence for benefits of stopping smoking, how best to assess tobacco dependence and what interventions currently work best to help pulmonary patients quit. Finally, we describe characteristics and management of any "hardcore" smoker who finds it difficult to quit with standard approaches. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Jimenez-Ruiz, C. A., Andreas, S., Lewis, K. E., Tonnesen, P., van Schayck, C. P., Hajek, P., Tonstad, S., Dautzenberg, B., Fletcher, M., Masefield, S., Powell, P., Hering, T., Nardini, S., Tonia, T., Gratziou, C. Tags: COPD and smoking Original Articles: ERS statement Source Type: research

Effects of quitting cannabis on respiratory symptoms
Smoking cannabis is associated with symptoms of bronchitis. Little is known about the persistence of symptoms after stopping cannabis use. We assessed associations between changes in cannabis use and respiratory symptoms in a population-based cohort of 1037 young adults. Participants were asked about cannabis and tobacco use at ages 18, 21, 26, 32 and 38 years. Symptoms of morning cough, sputum production, wheeze, dyspnoea on exertion and asthma diagnoses were ascertained at the same ages. Frequent cannabis use was defined as ≥52 occasions over the previous year. Associations between frequent cannabis use and respi...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Hancox, R. J., Shin, H. H., Gray, A. R., Poulton, R., Sears, M. R. Tags: COPD and smoking Original Articles: Smoking Source Type: research

Gait patterns in COPD: the Rotterdam Study
This study demonstrates that persons with COPD exhibit worse Rhythm, especially fallers with COPD. The degree of Rhythm deterioration was associated with the degree of airflow limitation, symptoms and frequency of exacerbations. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Lahousse, L., Verlinden, V. J. A., van der Geest, J. N., Joos, G. F., Hofman, A., Stricker, B. H. C., Brusselle, G. G., Ikram, M. A. Tags: COPD and smoking Original Articles: COPD Source Type: research

The relationship between asthma and suicidal behaviours: a systematic literature review
Asthma is a highly prevalent chronic condition worldwide, and is particularly common in younger people compared to other chronic conditions. Asthma can result in a number of symptoms that are detrimental to the quality of life of sufferers. The aim of the present systematic literature review was to analyse the existing literature on the relationship between asthma and fatal and nonfatal suicidal behaviours. Articles were retrieved from Scopus, PubMed, ProQuest and Web of Knowledge. We searched for the terms (suicid* OR self-harm) AND (asthma* OR "bronchial hyperreactivity") published in English-language peer-reviewed journ...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Barker, E., Kolves, K., De Leo, D. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Sleeping on animal fur is related to asthma outcomes in later childhood
Animal furs might represent a "proxy" for high and diverse microbial exposures within a critical time window of immune development. We assessed whether sleeping on animal fur shortly after birth is associated with asthma and atopy up to the age of 10 years. LISAplus participants (n=2441) from Munich and Leipzig, Germany, were included in the analysis. Animal fur exposure, cofactors and health outcomes were obtained periodically up to 10 years of age by parental questionnaires. Information on specific IgE to aeroallergens was available at 10 years. Cytokine-producing peripheral T-cells were assessed in a subg...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Tischer, C., Standl, M., Lehmann, I., Schaaf, B., von Berg, A., Heinrich, J. Tags: Epidemiology, occupational and environmental lung disease, Asthma and allergy, Paediatric pulmonology Original Articles: Asthma Source Type: research

Coeliac disease and asthma association in children: the role of antibiotic consumption
The relationship between coeliac disease and asthma has been scarcely investigated. Infant antibiotic exposure has been linked to both diseases. We evaluated the association between childhood coeliac disease and asthma and the role of antibiotics in the first year of life. We followed a cohort of children born in 1995–2011 in the Friuli-Venezia Giulia region (Italy). Prescriptions for antibiotics in the first year of life and subsequent treated asthma were retrieved from drug prescription records; coeliac disease incident cases were identified from pathology reports, hospital discharges and exemption from prescriptio...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Canova, C., Pitter, G., Ludvigsson, J. F., Romor, P., Zanier, L., Zanotti, R., Simonato, L. Tags: Asthma and allergy, Paediatric pulmonology Original Articles: Paediatric asthma Source Type: research

Airflow limitation by the Global Lungs Initiative equations in a cohort of very old adults
The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off. In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN) and fixed...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Turkeshi, E., Vaes, B., Andreeva, E., Mathei, C., Adriaensen, W., Van Pottelbergh, G., Degryse, J.-M. Tags: Lung structure and function Original Articles: Lung function Source Type: research

Future trends in cystic fibrosis demography in 34 European countries
Median survival has increased in people with cystic fibrosis (CF) during the past six decades, which has led to an increased number of adults with CF. The future impact of changes in CF demographics has not been evaluated. The aim of this study was to estimate the number of children and adults with CF in 34 European countries by 2025. Data were obtained from the European Cystic Fibrosis Society Patient Registry. Population forecasts were performed for countries that have extensive CF population coverage and at least 4 years of longitudinal data by modelling future entering and exiting flows in registry cohorts. For th...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Burgel, P.-R., Bellis, G., Olesen, H. V., Viviani, L., Zolin, A., Blasi, F., Elborn, J. S., on behalf of the ERS/ECFS Task Force on The Provision of Care for Adults with Cystic Fibrosis in Europe Tags: CF and non-CF bronchiectasis Original Articles: Cystic fibrosis Source Type: research

Obstructive sleep apnoea in the elderly: role of continuous positive airway pressure treatment
In conclusion, CPAP treatment resulted in an improvement in quality of life, sleep-related symptoms, anxiety and depression indexes and some neurocognitive aspects in elderly people with severe OSA. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Martinez-Garcia, M. A., Chiner, E., Hernandez, L., Cortes, J. P., Catalan, P., Ponce, S., Diaz, J. R., Pastor, E., Vigil, L., Carmona, C., Montserrat, J. M., Aizpuru, F., Lloberes, P., Mayos, M., Selma, M. J., Cifuentes, J. F., Munoz, A., on behalf of the Tags: Sleep medicine Original Articles: Sleep Source Type: research

Validation of two predictive models for survival in pulmonary arterial hypertension
The French Pulmonary Hypertension Network (FPHN) registry and the Registry to Evaluate Early And Long-term Pulmonary Arterial Hypertension Disease Management (REVEAL) have developed predictive models for survival in pulmonary arterial hypertension (PAH). In this collaboration, we assess the external validity (or generalisability) of the FPHN ItinérAIR-HTAP predictive equation and the REVEAL risk score calculator. Validation cohorts approximated the eligibility criteria defined for each model. The REVEAL cohort comprised 292 treatment-naïve, adult patients diagnosed <1 year prior to enrolment with idiopa...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Sitbon, O., Benza, R. L., Badesch, D. B., Barst, R. J., Elliott, C. G., Gressin, V., Lemarie, J.-C., Miller, D. P., Muros-Le Rouzic, E., Simonneau, G., Frost, A. E., Farber, H. W., Humbert, M., McGoon, M. D. Tags: Pulmonary vascular disease Original Articles: Pulmonary vascular diseases Source Type: research

Decreasing cost effectiveness of testing for latent TB in HIV in a low TB incidence area
Testing for latent tuberculosis infection (LTBI) in HIV-infected persons in low tuberculosis (TB) incidence areas is often recommended. Using contemporary, clinical data, we report the yield and cost-effectiveness of testing all HIV attendees, two current UK strategies and no LTBI testing. Economic modelling was performed utilising 10-year follow up data from a large HIV clinical cohort. Outcomes were numbers of cases of active TB and incremental cost per quality-adjusted life year (QALY) gained. Between 2000 and 2010, 256 people were treated for TB/HIV co-infection. 72 (28%) occurred ≥3 months after HIV diagnosis ...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Capocci, S., Smith, C., Morris, S., Bhagani, S., Cropley, I., Abubakar, I., Johnson, M., Lipman, M. Tags: Respiratory infections and tuberculosis Original Articles: Tuberculosis Source Type: research

Effectiveness of infliximab in refractory FDG PET-positive sarcoidosis
In conclusion, infliximab causes significant improvement in FVC in refractory 18F-FDG PET positive sarcoidosis. Especially in pulmonary disease, high 18F-FDG PET SUVmax values at treatment initiation predict clinically relevant lung function improvement. These results suggest that inclusion of 18F-FDG PET is useful in therapeutic decision-making in complex sarcoidosis. (Source: European Respiratory Journal)
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Vorselaars, A. D. M., Crommelin, H. A., Deneer, V. H. M., Meek, B., Claessen, A. M. E., Keijsers, R. G. M., van Moorsel, C. H. M., Grutters, J. C. Tags: Interstitial and orphan lung disease Original Articles: Sarcoidosis Source Type: research

Management of patients with idiopathic pulmonary fibrosis in clinical practice: the INSIGHTS-IPF registry
After introduction of the new international guidelines on idiopathic pulmonary fibrosis (IPF) in 2011, we investigated clinical management practices for patients with IPF according to physicians' diagnoses. A prospective, multicenter, noninterventional study with comprehensive quality measures including on-site source data verification was performed in Germany. 502 consecutive patients (171 newly diagnosed, 331 prevalent; mean±sd age 68.7±9.4 years, 77.9% males) with a mean disease duration of 2.3±3.5 years were enrolled. IPF diagnosis was based on clinical assessments and high-resolution com...
Source: European Respiratory Journal - June 30, 2015 Category: Respiratory Medicine Authors: Behr, J., Kreuter, M., Hoeper, M. M., Wirtz, H., Klotsche, J., Koschel, D., Andreas, S., Claussen, M., Grohe, C., Wilkens, H., Randerath, W., Skowasch, D., Meyer, F. J., Kirschner, J., Glaser, S., Herth, F. J. F., Welte, T., Huber, R. M., Neurohr, C., Sch Tags: Interstitial and orphan lung disease Original Articles: Interstitial lung diseases Source Type: research