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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

The changing paradigm in pulmonary hypertension trials: longer duration, new endpoints
Purpose of review: Approved therapies for pulmonary arterial hypertension (PAH) currently consist of 12 agents, the majority of which were approved following short-term randomized clinical trials using change in 6 minute walk distance (6MWD) as the primary outcome. However, there is growing concern that significant improvements in this measure do not translate into morbidity and mortality benefits. Recent findings: As a result of data questioning the association between improvements in 6 minute walk distance and improvements in outcome, PAH clinical trial design is increasingly utilizing morbidity and mortality events as a...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Richard N. Channick and Marc Humbert Source Type: research

Pulmonary hypertension in sickle cell disease
Purpose of review: This review highlights the prevalence of pulmonary hypertension as a chronic complication of sickle cell disease (SCD) and its importance in the prognosis. Recent findings: In recent years, the limitations of echocardiogram for the appropriate diagnosis of SCD-associated pulmonary hypertension have been demonstrated, emphasizing the need of invasive hemodynamics assessment before any specific treatment for pulmonary hypertension is considered. The hemodynamic profile observed in this clinical situation is characterized by elevated cardiac output and low pulmonary vascular resistance that differs consider...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Richard N. Channick and Marc Humbert Source Type: research

Balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension
Purpose of review: Chronic thromboembolic pulmonary hypertension (CTEPH), especially when severe in patients unsuited for pulmonary endarterectomy, has a poor prognosis. Balloon pulmonary angioplasty (BPA) is a new catheter-based alternative treatment option for patients with inoperable CTEPH. BPA has not been widely accepted, however, primarily because of possible fatal complications, although effects described in 2001 were encouraging. Recent studies about BPA from Japan and Norway are promising. However, this emerging catheter-based intervention is still considered to be experimental because of a number of concerns and ...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Richard N. Channick and Marc Humbert Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Pulmonary Medicine)
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: Editorial Introductions Source Type: research

Progress in the management of acute pulmonary embolism
Purpose of review: Pulmonary embolism is a major contributor to global disease burden worldwide. The 2014 guidelines of the European Society of Cardiology, endorsed by the European Respiratory Society, emphasize the need for initial and advanced risk stratification as well as risk-adapted treatment to ensure the highest quality of care. This review summarizes the progress in pulmonary embolism diagnosis, risk assessment, and treatment. Recent findings: Major advances of the past 12 months include age-related biomarker cutoff levels for optimising pulmonary embolism diagnosis and risk stratification; detection of (isolated)...
Source: Current Opinion in Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Tags: DISORDERS OF THE PULMONARY CIRCULATION: Edited by Richard N. Channick and Marc Humbert Source Type: research

An effective combination of sanger and next generation sequencing in diagnostics of primary ciliary dyskinesia
ConclusionsWe present a combination of Sanger sequencing with an NGS panel for known and candidate PCD genes, implemented in a moderate‐size national collection of patients. This strategy has proven to be cost‐effective, rapid and reliable, and was able to detect the causative gene in two thirds of our PCD patients. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 31, 2015 Category: Respiratory Medicine Authors: Jana Djakow, Lenka Kramná, Lenka Dušátková, Jiří Uhlík, Juha‐Pekka Pursiheimo, Tamara Svobodová, Petr Pohunek, Ondřej Cinek Tags: Original Article Source Type: research

New Treatments for Idiopathic Pulmonary Fibrosis: ‘Die Another Day' if Diagnosed Early?
Respiration (Source: Respiration)
Source: Respiration - July 31, 2015 Category: Respiratory Medicine Source Type: research

Worsening of Respiratory Status during Neutropenia Recovery in Noncritically Ill Hematological Patients: Results of a Prospective Multicenter Study
Conclusion: Up to one third of noncritically ill hematological patients with expected neutropenia of more than 7 days experience WRS during NR. Clinical consequences and risk factors for WRS during NR remain to be evaluated.Respiration (Source: Respiration)
Source: Respiration - July 31, 2015 Category: Respiratory Medicine Source Type: research

Percutaneous Endoscopic Gastrostomy in Amyotrophic Lateral Sclerosis
Conclusions: In conclusion, PEG tube placement in patients with ALS seems to be a safe procedure in patients without significant respiratory compromise. In patients with FVC (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - July 31, 2015 Category: Journals (General) Tags: Clinical Investigation Source Type: research

Psychiatric hospital admission and long‐term care in patients with very‐late‐onset schizophrenia‐like psychosis
ConclusionThe patients with VLOSLP needed more psychiatric hospital care than those with earlier illness onset. Ending up in LTC/LLP was equally common in both onset groups, but some physical diseases, such as cardiovascular and respiratory, diminished the likelihood of this. Copyright © 2015 John Wiley & Sons, Ltd. (Source: International Journal of Geriatric Psychiatry)
Source: International Journal of Geriatric Psychiatry - July 31, 2015 Category: Geriatrics Authors: Tiina Talaslahti, Hanna‐Mari Alanen, Helinä Hakko, Matti Isohanni, Olli Kampman, Unto Häkkinen, Esa Leinonen Tags: Research Article Source Type: research

Recent patents in pulmonary delivery of macromolecules.
This article reviews the advances in pulmonary drug delivery systems by focusing on the recent patents in delivery of macromolecules. Furthermore, recent patents in gene delivery to the lungs have also been discussed. List of patents included in this review is comprehensive in terms of pulmonary delivery of therapeutics. It includes inventions related to proteins and peptides, DNA therapeutics, siRNA and other genetic materials with therapeutic applications. The diseases targeted by these therapeutic molecules are varied including but not limited to different forms of cancer, respiratory diseases etc. PMID: 26219931 [P...
Source: Recent Patents on Drug Delivery and Formulation - July 31, 2015 Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research

Easy Diagnosis of Aortic Invasion in Patients with Lung Cancer Using Cine Magnetic Resonance Imaging
We describe the case of a patient easily diagnosed to be without aortic invasion using cine magnetic resonance imaging (MRI). We herein report the case of an 80-year-old male who presented a lung tumor. The transbronchial lung washing cytology findings were consistent with those of adenocarcinoma. In addition, the computed tomography findings indicated suspected aortic invasion of the lung tumor, as the mass girdled the descending aorta beyond 120° adjoining at a length of 10 cm. However, cine MRI display clearly demonstrated a clear area of isolation between the aorta and lung tissue based on differences in the heart rhy...
Source: Case Reports in Oncology - July 31, 2015 Category: Cancer & Oncology Source Type: research

Significant Enhancement of ATP-Synthesis in Cardiomyocytes By Electric Microcurrent
The cardiomyocytes of failing hearts show a significant reduced ability to synthesize ATP. On the one hand, the ATP synthesis depends on the level of the H+ based mitochondrial membrane potential which is impaired in heart failure and which in turn correlates to the electron transfer rate of the respiratory chain of the mitochondria. On the other hand, the electron transfer rate can be changed by external electric fields. We thought to examine the effect of electric fields concomitant with low and high electric microcurrent on the capability of mitochondria of cultured cardiomyocytes from spontaneous hypertensive rates to ...
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Karin Macfelda, Alexander Holly, Johannes Mueller Tags: Cardiovascular Physiology I Source Type: research

Relationship of Right Ventricular Function and Respiratory Status in a Large Cohort of Duchenne Muscular Dystrophy
The relationship of right ventricular (RV) and pulmonary function in Duchenne muscular dystrophy (DMD) has not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV ejection fraction (EF) and ventilatory capacity in a DMD cohort. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Muddassir Mehmood, Michael D. Taylor, John L. Jefferies, Subha V. Raman, Stephanie Ambach, Wojciech Mazur Tags: Cardiovascular Structure/Imaging I Source Type: research

Heart Rate and Respiration During Activity Measured by an Implanted Device Correlate well with those Measured by a CPX Machine
Heart Failure (HF) is classified in part by severity of symptoms such as fatigue and shortness of breath experienced during exertion. Physiologic variables associated with these symptoms, such as heart rate (HR) and respiratory rate (RR) measured during activity, could be useful to monitor disease progression. In the PRE-SENSE study, physiologic response to activity (PRA) measured from an implanted device were compared to data from external cardiopulmonary exercise testing equipment (CPX) during a graded exercise test. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Alan J. Bank, John Chronakos, Kenneth C. Beck, Paji Vitoff, Colleen Delaney, Julie Thompson, Yi Zhang Tags: Surgery/Transplantation/Devices I Source Type: research

Device-Measured Rapid Shallow Breathing With Exertion Worsens Prior to Heart Failure Decompensation
Respiratory complaints are common prior to heart failure events (HFEs) and may present as an elevated respiratory rate (RR) or decreased tidal volume (TV). We hypothesized that the changes in device-based respiratory measures in the week leading up to HFE would be larger with exertion than at rest. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Seth Rials, Bela Merkely, Roy Gardner, Viktoria Averina, Robert Sweeney, Yi Zhang, Qi An, John Boehmer Tags: Management Strategies, Adherence/Self Care I Source Type: research

Heart Failure Patients With Dyspnea Had Higher Device-Based Respiratory Rate Than Those Without
Shortness of breath is the most common symptom in heart failure (HF) patients. Implantable devices are capable of monitoring respiration rate trend (RRT) by measuring intra-thoracic impedance. We hypothesized that patients with perceived dyspnea had an elevated RRT compared to those without. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - July 31, 2015 Category: Cardiology Authors: Roy S. Gardner, Bela Merkely, Pier Lambiase, Yi Zhang, Qi An, Viktoria Averina, Robert Sweeney, Scott Wehrenberg Tags: Management Strategies, Adherence/Self Care II Source Type: research

Eltrombopag for the treatment of children with persistent and chronic immune thrombocytopenia (PETIT): a randomised, multicentre, placebo-controlled study
Publication date: Available online 28 July 2015 Source:The Lancet Haematology Author(s): James B Bussel, Purificación Garcia de Miguel, Jenny M Despotovic, John D Grainger, Julián Sevilla, Victor S Blanchette, Lakshmanan Krishnamurti, Philip Connor, Michèle David, Koh B Boayue, Dana C Matthews, Michele P Lambert, Lisa M Marcello, Malini Iyengar, Geoffrey W Chan, Karen D Chagin, Dickens Theodore, Christine K Bailey, Kalpana K Bakshi Background The oral thrombopoietin receptor agonist eltrombopag is approved for treatment of adults with chronic immune thrombocytopenia. In the PETIT trial, we aimed to ...
Source: The Lancet Haematology - July 31, 2015 Category: Hematology Source Type: research

First clinical use of a bioprosthetic total artificial heart: report of two cases
We report here the device characteristics and its first clinical applications in two patients with end-stage dilated cardiomyopathy. The aim of the study was to evaluate safety and feasibility of the CARMAT TAH for patients at imminent risk of death from biventricular heart failure and not eligible for transplant. Methods The C-TAH is an implantable electro-hydraulically actuated pulsatile biventricular pump. All components, batteries excepted, are embodied in a single device positioned in the pericardial sac after excision of the native ventricles. We selected patients admitted to hospital who were at imminent risk of de...
Source: The Lancet - July 31, 2015 Category: Journals (General) Source Type: research

Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial
Publication date: Available online 28 July 2015 Source:The Lancet Author(s): John D Grainger, Franco Locatelli, Thirachit Chotsampancharoen, Elena Donyush, Bunchoo Pongtanakul, Patcharee Komvilaisak, Darintr Sosothikul, Guillermo Drelichman, Nongnuch Sirachainan, Susanne Holzhauer, Vladimir Lebedev, Richard Lemons, Dagmar Pospisilova, Ugo Ramenghi, James B Bussel, Kalpana K Bakshi, Malini Iyengar, Geoffrey W Chan, Karen D Chagin, Dickens Theodore, Lisa M Marcello, Christine K Bailey Background The thrombopoietin receptor agonist eltrombopag has been shown to be safe, tolerable, and effective for adu...
Source: The Lancet - July 31, 2015 Category: Journals (General) Source Type: research

Demographic and clinical characteristics of deaths associated with influenza A(H1N1) pdm09 in Central America and Dominican Republic 2009–2010
Conclusions: The pandemic killed young adults, pregnant women and those with pre-existing medical conditions. Most sought care too late to fully benefit from oseltamivir. We recommend countries review antiviral treatment policies for people at high risk of developing complications. (Source: BMC Public Health)
Source: BMC Public Health - July 31, 2015 Category: Consumer Health News Authors: Rafael ChaconSara MirzaDavid RodriguezAntonio ParedesGiselle GuzmanLourdes MorenoCecilia ThenJorge JaraNatalia BlancoLuis BonillaWilfrido ClaraPercy MinayaRakhee PalekarEduardo Azziz-Baumgartner Source Type: research

Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case-Control Study
CONCLUSIONS: Antibiotics were associated with newly diagnosed JIA in a dose- and time-dependent fashion in a large pediatric population. Antibiotic exposure may play a role in JIA pathogenesis, perhaps mediated through alterations in the microbiome. (Source: PEDIATRICS)
Source: PEDIATRICS - July 31, 2015 Category: Pediatrics Authors: Horton, D. B., Scott, F. I., Haynes, K., Putt, M. E., Rose, C. D., Lewis, J. D., Strom, B. L. Tags: Infectious Diseases, Epidemiology, Rheumatology/Musculoskeletal Disorders Article Source Type: research

Outbreak of Mycoplasma pneumoniae-Associated Stevens-Johnson Syndrome
CONCLUSIONS: We report the largest outbreak of SJS in children, which was also predominately associated with Mp infection. Mp-associated SJS was associated with a distinct clinical presentation that included less extensive skin disease, an elevated erythrocyte sedimentation rate, and evidence of a preceding respiratory infection. (Source: PEDIATRICS)
Source: PEDIATRICS - July 31, 2015 Category: Pediatrics Authors: Olson, D., Watkins, L. K. F., Demirjian, A., Lin, X., Robinson, C. C., Pretty, K., Benitez, A. J., Winchell, J. M., Diaz, M. H., Miller, L. A., Foo, T. A., Mason, M. D., Lauper, U. L., Kupfer, O., Kennedy, J., Glode, M. P., Kutty, P. K., Dominguez, S. R. Tags: Dermatology, Infectious Diseases, Epidemiology Article Source Type: research

Implementation of Postoperative Respiratory Care for Pediatric Orthopedic Patients
CONCLUSIONS: We implemented an innovative respiratory care algorithm in hip and spine surgery patients by empowering RTs and engaging families to participate in care. We found that this approach was associated with decreased prolonged oxygen use in patients with chronic underlying conditions. (Source: PEDIATRICS)
Source: PEDIATRICS - July 31, 2015 Category: Pediatrics Authors: Shaughnessy, E. E., White, C., Shah, S. S., Hubbell, B., Sucharew, H., Sawnani, H. Tags: Administration/Practice Management, Quality Improvement, Orthopedic Medicine Quality Report Source Type: research

Diagnostic and prognostic utility of mid-expiratory flow rate in older community-dwelling persons with respiratory symptoms, but without chronic obstructive pulmonary disease
Background: The maximal expiratory flow at 50 % of the forced vital capacity (MEF 50 ) is the flow where half of forced vital capacity (FVC) remains to be exhaled. A reduced MEF 50 has been suggested as a surrogate marker of small airways disease. The diagnostic and prognostic utility of this easy to assess spirometric variable in persons with respiratory symptoms, but without COPD is unclear. Methods: We used data from the UHFO-COPD cohort in which 405 community-dwelling persons aged 65 years or over, and a general practitioner’s diagnosis of chronic obstructive pulmonary dis...
Source: BMC Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Authors: Gülmisal GüderSusanne BrennerStefan StörkMatthias HeldBerna BroekhuizenJan-Willem LammersArno HoesFrans Rutten Source Type: research

Cardiorespiratory effects of recruitment maneuvers and positive end expiratory pressure in an experimental context of acute lung injury and pulmonary hypertension
Conclusions: During ventilation with open lung strategy, the role of PHT in conferring protection from the adverse respiratory consequences of ALI was evidenced. This finding advocates the safety of RM and PEEP in improving elastance and advancing lung reopening in the simultaneous presence of PHT and ALI. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Authors: Camille DorasMorgan Le GuenFerenc PetákWalid Habre Source Type: research

Structural and functional correlations in a large animal model of bleomycin-induced pulmonary fibrosis
This study aimed to determine whether bleomycin-induced fibrosis and associated functional changes persisted over a seven-week period. Methods: Two separate lung segments in nine sheep received two challenges two weeks apart of either, 3U bleomycin (BLM), or saline (control). Lung function in these segments was assessed by a wedged-bronchoscope procedure after bleomycin treatment. Lung tissue, and an ex vivo CT analysis were used to assess for the persistence of inflammation, fibrosis and collagen content in this model. Results: Fibrotic changes persisted up to seven weeks in bleomycin-treated isolated lung segments (Patho...
Source: BMC Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Authors: Louise OrganBarbara BacciEmmanuel KoumoundourosGarry BarchamMarjorie MilneWayne KimptonChrishan SamuelKen Snibson Source Type: research

Study protocol for a randomised controlled trial evaluating the efficacy of a telehealth program – management of asthma with supportive telehealth of respiratory function in pregnancy (MASTERY © )
This study aims to evaluate the use of telehealth for remotely monitoring lung function and optimising asthma control during pregnancy. Methods: A randomised controlled trial comparing usual care with a telehealth program (MASTERY © ) has been conducted. The intervention comprised a mobile application – Breathe-easy © supported by a Bluetooth-enabled handheld device (COPD-6®), which was used for self-monitoring of lung function (FEV 1 , FEV 6 ) twice daily, and recording asthma symptoms and medication usage weekly; and a written asthma action pl...
Source: BMC Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Authors: Elida ZairinaMichael AbramsonChristine McDonaldJonathan LiThanuja DharmasiriKay StewartSusan WalkerEldho PaulJohnson George Source Type: research

Protocadherin-1 is a glucocorticoid-responsive critical regulator of airway epithelial barrier function
Conclusion: These results suggest that PCDH1 is important for airway function as a physical barrier, and its dysfunction is involved in the pathogenesis of allergic airway inflammation. We also suggest that glucocorticoids promotes epithelial barrier integrity by inducing PCDH1. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - July 31, 2015 Category: Respiratory Medicine Authors: Yutaka KozuYasuhiro GonShuichiro MaruokaKuroda KazumichiAkiko SekiyamaHiroyuki KishiYasuyuki NomuraMinoru IkedaShu Hashimoto Source Type: research

Are administrative data valid when measuring patient safety in hospitals? A comparison of data collection methods using a chart review and administrative data
Conclusions Indicators based on German administrative data deviate widely from indicators based on clinical data. Therefore, hospitals should be cautious to use indicators based on administrative data for quality assurance. However, some might be useful for case findings and quality improvement. The precision of the evaluated indicators needs further development to detect AEs by the valid use of administrative data. (Source: International Journal for Quality in Health Care)
Source: International Journal for Quality in Health Care - July 31, 2015 Category: Global & Universal Authors: Maass, C., Kuske, S., Lessing, C., Schrappe, M. Tags: Papers Source Type: research

Engaging staff to improve quality and safety in an austere medical environment: a case-control study in two Sierra Leonean hospitals
Quality problem or issue Inadequate observance of basic processes in patient care such as patient monitoring and documentation practices are potential impediments to the timely diagnoses and management of patients. These gaps exist in low resource settings such as Sierra Leone and can be attributed to a myriad of factors such as workforce and technology deficiencies. Initial assessment In the study site, only 12.4% of four critical vital signs were documented in the pre-intervention period. Choice of solution Implement a failure mode and effects analysis (FMEA) to improve documentation of four patient vital signs: temper...
Source: International Journal for Quality in Health Care - July 31, 2015 Category: Global & Universal Authors: Rosen, M. A., Chima, A. M., Sampson, J. B., Jackson, E. V., Koka, R., Marx, M. K., Kamara, T. B., Ogbuagu, O. U., Lee, B. H. Tags: Papers Source Type: research

Short-term exposure to L-type calcium channel blocker, verapamil, alters the expression pattern of calcium-binding proteins in the brain of goldfish, Carassius auratus
Publication date: Available online 26 July 2015 Source:Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology Author(s): Nikhil V. Palande, Rahul C. Bhoyar, Saikat P. Biswas, Arun G. Jadhao The influx of calcium ions (Ca2+) is responsible for various physiological events including neurotransmitter release and synaptic modulation. The L-type voltage dependent calcium channels (L-type VDCCs) transport Ca2+ across the membrane. Calcium-binding proteins (CaBPs) bind free cytosolic Ca2+ and prevent excitotoxicity caused by sudden increase in cytoplasmic Ca2+. The present study was aimed to under...
Source: Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology - July 31, 2015 Category: Toxicology Source Type: research

[In Brief] This week's section
In science news around the world, NASA's New Horizons spacecraft spies nitrogen ice flows on Pluto as well as a ring of haze around the dwarf planet, the first-ever malaria vaccine clears the first hurdle along a complicated path to approval, the Kepler satellite spies the most Earth-like exoplanet yet, a new technique offers a way to spot hidden HIV in the body's tissues, South Korea declares the Middle East respiratory syndrome outbreak in the country over after 23 days of no new cases, and more. Also, one of Spain's star mathematicians is removed as the head of a national research institute over accusations that the cen...
Source: Science: Current Issue - July 31, 2015 Category: Science Authors: Science Magazine (mailto:soleditor at aaas.org) Source Type: research

Leydig cell steroidogenesis unexpectedly escapes mitochondrial dysfunction in prematurely aging mice [Research Communication]
Point mutations and deletions of mitochondrial DNA (mtDNA) accumulate in tissues during aging in animals and humans and are the basis for mitochondrial diseases. Testosterone synthesis occurs in the mitochondria of Leydig cells. Mitochondrial dysfunction (as induced here experimentally in mtDNA mutator mice that carry a proofreading-deficient form of mtDNA polymerase , leading to mitochondrial dysfunction in all cells types so far studied) would therefore be expected to lead to low testosterone levels. Although mtDNA mutator mice showed a dramatic reduction in testicle weight (only 15% remaining) and similar decreases in n...
Source: FASEB Journal - July 31, 2015 Category: Biology Authors: Shabalina, I. G., Landreh, L., Edgar, D., Hou, M., Gibanova, N., Atanassova, N., Petrovic, N., Hultenby, K., Soder, O., Nedergaard, J., Svechnikov, K. Tags: Research Communication Source Type: research

Respiratory chain protein turnover rates in mice are highly heterogeneous but strikingly conserved across tissues, ages, and treatments [Research Communication]
The mitochondrial respiratory chain (RC) produces most of the cellular ATP and requires strict quality-control mechanisms. To examine RC subunit proteostasis in vivo, we measured RC protein half-lives (HLs) in mice by liquid chromatography-tandem mass spectrometry with metabolic [2H3]-leucine heavy isotope labeling under divergent conditions. We studied 7 tissues/fractions of young and old mice on control diet or one of 2 diet regimens (caloric restriction or rapamycin) that altered protein turnover (42 conditions in total). We observed a 6.5-fold difference in mean HL across tissues and an 11.5-fold difference across all ...
Source: FASEB Journal - July 31, 2015 Category: Biology Authors: Karunadharma, P. P., Basisty, N., Chiao, Y. A., Dai, D.-F., Drake, R., Levy, N., Koh, W. J., Emond, M. J., Kruse, S., Marcinek, D., Maccoss, M. J., Rabinovitch, P. S. Tags: Research Communication Source Type: research

Sensors, Vol. 15, Pages 18834-18850: A Nano-Thin Film-Based Prototype QCM Sensor Array for Monitoring Human Breath and Respiratory Patterns
Quartz crystal microbalance (QCM) sensor array was developed for multi-purpose human respiration assessment. The sensor system was designed to provide feedback for human respiration. Thorough optimization of measurement conditions: air flow, temperature in the QCM chamber, frequency measurement rate, and electrode position regarding to the gas flow—was performed. As shown, acquisition of respiratory parameters (rate and respiratory pattern) could be achieved even with a single electrode used in the system. The prototype system contains eight available QCM channels that can be potentially used for selective responses to c...
Source: Sensors - July 31, 2015 Category: Biotechnology Authors: Roman SelyanchynShunichi WakamatsuKenshi HayashiSeung-Woo Lee Tags: Article Source Type: research

Sensors, Vol. 15, Pages 18801-18812: The Structure Design of Piezoelectric Poly(vinylidene Fluoride) (PVDF) Polymer-Based Sensor Patch for the Respiration Monitoring under Dynamic Walking Conditions
This study reports a piezoelectric poly(vinylidene fluoride) (PVDF) polymer-based sensor patch for respiration detections in dynamic walking condition. The working mechanism of respiration signal generation is based on the periodical deformations on a human chest wall during the respiratory movements, which in turn mechanically stretch the piezoelectric PVDF film to generate the corresponding electrical signals. In this study, the PVDF sensing film was completely encapsulated within the sensor patch forming a mass-spring-damper mechanical system to prevent the noises generated in a dynamic condition. To verify the design o...
Source: Sensors - July 31, 2015 Category: Biotechnology Authors: Kin-Fong LeiYi-Zheng HsiehYi-Yuan ChiuMin-Hsien Wu Tags: Article Source Type: research

Acupuncture at Nèiguān ( PC 6) in combination with respiratory reinforcing and reducing method for 38 cases of cardiac neurosis
Conclusions Acupuncture at PC 6 in combination with respiratory reinforcing and reducing method is effective in treatment of cardiac neurosis. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - July 31, 2015 Category: Complementary Medicine Source Type: research

Notes from the Field: Large Outbreak of Botulism Associated with a Church Potluck Meal - Ohio, 2015.
Abstract On April 21, 2015, the Fairfield Medical Center (FMC) and Fairfield Department of Health contacted the Ohio Department of Health (ODH) about a patient suspected of having botulism in Fairfield County, Ohio. Botulism is a severe, potentially fatal neuroparalytic illness.* A single case is a public health emergency, because it can signal an outbreak. Within 2 hours of health department notification, four more patients with similar clinical features arrived at FMC's emergency department. Later that afternoon, one patient died of respiratory failure shortly after arriving at the emergency department. All affec...
Source: MMWR Morb Mortal Wkl... - July 31, 2015 Category: Epidemiology Authors: McCarty CL, Angelo K, Beer KD, Cibulskas-White K, Quinn K, Fijter S, Bokanyi R, Germain ES, Baransi K, Barlow K, Shafer G, Hanna L, Spindler K, Walz E, DiOrio M, Jackson BR, Luquez C, Mahon BE, Basler C, Curran K, Matanock A, Walsh K, Slifka KJ, Rao AK Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Developmental Alterations of the Auditory Brainstem Centers - Pathogenetic Implications in Sudden Infant Death Syndrome
Sudden Infant Death Syndrome (SIDS), despite the success of campaigns to reduce its risks, is the leading cause of infant death in the Western world. Even though the pathogenesis remains unexplained, brainstem abnormalities of the neuronal network that mediates breathing and protective responses to asphyxia, particularly in the arousal phase from sleep, are believed to play a fundamental role. This is the first study to identify, in SIDS, developmental defects of specific brainstem centers involved in hearing pathways, particularly in the cochlear and vestibular nuclei, in the superior olivary complex and in the inferior c...
Source: Journal of the Neurological Sciences - July 31, 2015 Category: Neurology Authors: Anna M. Lavezzi, Giulia Ottaviani, Luigi Matturri Source Type: research

Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomised controlled trial
Publication date: Available online 30 July 2015 Source:The Lancet Neurology Author(s): DiPALS Writing CommitteeDiPALS Study Group Collaborators Background Non-invasive ventilation is part of the standard of care for treatment of respiratory failure in patients with amyotrophic lateral sclerosis (ALS). The NeuRx RA/4 Diaphragm Pacing System has received Humanitarian Device Exemption approval from the US Food and Drug Administration for treatment of respiratory failure in patients with ALS. We aimed to establish the safety and efficacy of diaphragm pacing with this system in patients with respiratory muscle weakness due to...
Source: The Lancet Neurology - July 31, 2015 Category: Neurology Source Type: research

A Side-by-side Comparison of T cell Reactivity to Fifty-nine Antigens in Diverse Populations from five Continents
We compared T cell recognition of 59 prevalently recognized Mycobacterium tuberculosis (MTB) antigens in individuals latently infected with MTB (LTBI), and uninfected individuals with previous BCG vaccination, from nine locations and populations with different HLA distribution, MTB exposure rates, and standards of TB care. This comparison revealed similar response magnitudes in diverse LTBI and BCG-vaccinated cohorts and significant correlation between responses in LTBIs from the USA and other locations. (Source: Tuberculosis)
Source: Tuberculosis - July 31, 2015 Category: Respiratory Medicine Authors: Chelsea Carpenter, John Sidney, Ravi Kolla, Kaustuv Nayak, Helena Tomiyama, Claudia Tomiyama, Oscar A. Padilla, Virginie Rozot, Syed F. Ahamed, Carlos Ponte, Valeria Rolla, Paulo R. Antas, Anmol Chandele, John Kenneth, Seetha Laxmi, Edward Makgotlho, Vale Tags: Immunological Aspects Source Type: research

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As part of the August issue, the European Respiratory Journal presents the 56th in its series of podcasts, in which chief editor Marc Humbert discusses genetic aspects of familial pulmonary fibrosis with with Prof. Bruno Crestani, Université Paris Diderot, France. (Source: European Respiratory Journal)
Source: European Respiratory Journal - July 31, 2015 Category: Respiratory Medicine Tags: Electronic Resources Source Type: research