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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Past, Present, and Future Rehabilitation Practice Patterns for Patients with Heart Failure
The recent European Society of Cardiology position paper strongly advises participation of patients with stable heart failure (HF) in structured exercise training (ET) programs, and in most recent years considerable efforts have been put into standardization of exercise prescription. Up to now, 3 ET modalities are proposed for HF populations with variable combinations and extent of effects: (1) endurance aerobic (continuous and interval); (2) strength/resistance; (3) respiratory. Irrespective of ET modalities, most of the studies have clearly demonstrated significant improvements in exercise physiology (ie, oxygen consumpt...
Source: Heart Failure Clinics - November 27, 2014 Category: Cardiology Authors: Valentina Labate, Marco Guazzi Source Type: research

The contributions of respiration and glycolysis to extracellular acid production
Conclusion Measurement of glycolytic rate using extracellular acidification requires differentiation between respiratory and glycolytic acid production. General significance The data presented here demonstrate the importance of this correction when extracellular acidification is used for quantitative measurement of glycolytic flux to lactate. We describe a simple way to correct the measured extracellular acidification rate for respiratory acid production, using simultaneous measurement of oxygen consumption rate. Summary statement Extracellular acidification is often assumed to result solely from glycolytic lactate produ...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - November 27, 2014 Category: Biochemistry Source Type: research

Cytochrome bd from Escherichia coli catalyzes peroxynitrite decomposition
Publication date: February 2015 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1847, Issue 2 Author(s): Vitaliy B. Borisov , Elena Forte , Sergey A. Siletsky , Paolo Sarti , Alessandro Giuffrè Cytochrome bd is a prokaryotic respiratory quinol oxidase phylogenetically unrelated to heme-copper oxidases, that was found to promote virulence in some bacterial pathogens. Cytochrome bd from Escherichia coli was previously reported to contribute not only to proton motive force generation, but also to bacterial resistance to nitric oxide (NO) and hydrogen peroxide (H2O2). Here, we investigated the interaction...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - November 27, 2014 Category: Biochemistry Source Type: research

Infrared and Raman spectroscopic investigation of the reaction mechanism of cytochrome c oxidase
This article is part of a Special Issue entitled: Vibrational spectroscopies and bioenergetic systems. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - November 27, 2014 Category: Biochemistry Source Type: research

Infrared spectroscopic markers of quinones in proteins from the respiratory chain
This article is part of a Special Issue entitled: Vibrational spectroscopies and bioenergetic systems. (Source: Biochimica et Biophysica Acta (BBA) Bioenergetics)
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - November 27, 2014 Category: Biochemistry Source Type: research

Evaluation of fast-track diagnostics and TaqMan array card real-time PCR assays for the detection of respiratory pathogens
Publication date: December 2014 Source:Journal of Microbiological Methods, Volume 107 Author(s): Amanda J. Driscoll , Ruth A. Karron , Niranjan Bhat , Bhagvanji Thumar , Maja Kodani , Barry S. Fields , Cynthia G. Whitney , Orin S. Levine , Katherine L. O'Brien , David R. Murdoch Several commercial assays are now available to detect the nucleic acid of multiple respiratory pathogens from a single specimen. Head-to-head comparisons of such assays using a single set of standard specimens provide additional information about key assay parameters such as sensitivity, specificity and lower limits of detection, and help to info...
Source: Journal of Microbiological Methods - November 27, 2014 Category: Microbiology Source Type: research

Biofilm formation by virulent and non-virulent strains of Haemophilus parasuis
Abstract Haemophilus parasuis is a commensal bacterium of the upper respiratory tract of healthy pigs. It is also the etiological agent of Glässer’s disease, a systemic disease characterized by polyarthritis, fibrinous polyserositis and meningitis, which causes high morbidity and mortality in piglets. The aim of this study was to evaluate biofilm formation by well-characterized virulent and non-virulent strains of H. parasuis. We observed that non-virulent strains isolated from the nasal cavities of healthy pigs formed significantly (p < 0.05) more biofilms than virulent strains isolated fro...
Source: Veterinary Research - November 27, 2014 Category: Veterinary Research Source Type: research

Engineering the PRRS virus genome: Updates and perspectives
Publication date: 5 December 2014 Source:Veterinary Microbiology, Volume 174, Issues 3–4 Author(s): Mingyuan Han , Dongwan Yoo Porcine reproductive and respiratory syndrome virus (PRRSV) is endemic in most pig producing countries worldwide and causes enormous economic losses to the pork industry. Infectious clones for PRRSV have been constructed, and so far at least 14 different infectious clones are available representing both genotypes I and II. Two strategies have been taken for progeny reconstitution: RNA transfection and DNA transfection. Mutations, insertions, deletions, and replacements of the viral genome have ...
Source: Veterinary Microbiology - November 27, 2014 Category: Veterinary Research Source Type: research

GP5 expression in Marc-145 cells inhibits porcine reproductive and respiratory syndrome virus infection by inducing beta interferon activity
Publication date: 5 December 2014 Source:Veterinary Microbiology, Volume 174, Issues 3–4 Author(s): Jiming Gao , Pengchao Ji , Maodong Zhang , Xiangpeng Wang , Na Li , Chengbao Wang , Shuqi Xiao , Yang Mu , Qin Zhao , Taofeng Du , Yani Sun , Julian A. Hiscox , Gaiping Zhang , En-Min Zhou The major neutralizing epitope of porcine reproductive and respiratory syndrome virus (PRRSV) is mainly located on virus glycoprotein 5 (GP5). Immunization with exogenous GP5 or exposure to native GP5 by means of DNA immunization can provide some degree of immune protection to PRRSV infection in pigs. However, during PRRSV infection in...
Source: Veterinary Microbiology - November 27, 2014 Category: Veterinary Research Source Type: research

In vivo effect of deoxynivalenol (DON) naturally contaminated feed on porcine reproductive and respiratory syndrome virus (PRRSV) infection
This study demonstrate that high concentrations of DON naturally contaminated feed decreased the immune response against PRRSV and influenced the course of PRRSV infection in pigs. (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - November 27, 2014 Category: Veterinary Research Source Type: research

Linear epitope recognition antibodies strongly respond to the C-terminal domain of HP-PRRSV GP5
Publication date: 5 December 2014 Source:Veterinary Microbiology, Volume 174, Issues 3–4 Author(s): Xinglong Wang , Li Qui , Yu Dang , Sha Xiao , Shuxia Zhang , Zengqi Yang A total of 155 peptides derived from the highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) glycoprotein 5 (GP5) were printed on a chip to reveal the antigen reaction characteristics of the protein. The reactions of these peptides to HP-PRRSV-specific pig serum were scanned and quantified using fluorescence intensity via the PepSlide® Analyzer software. The intensity plots showed different reactions in the different se...
Source: Veterinary Microbiology - November 27, 2014 Category: Veterinary Research Source Type: research

The involvement of norepinephrine in pain modulation in the nucleus accumbens of morphine-dependent rats
In this study, we examined the role of NE on the evoked discharges of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the nucleus accumbens (NAc) of rats, following the development of morphine dependence. Our results revealed that NE inhibited the evoked discharges of PENs and attenuated the inhibition of PINs, while phentolamine enhanced the evoked discharges of PENs and facilitated the inhibition of PINs. These results indicate that the inhibitory action of NE on pain modulation acts via alpha adrenoceptors in the NAc of morphine-dependent rats. (Source: Neuroscience Letters)
Source: Neuroscience Letters - November 27, 2014 Category: Neuroscience Source Type: research

Death by dengue fever in a Brazilian child: a case report
Conclusion: Considering that the death occurred during the major endemic seasonal period for dengue fever, primary clinical evidence suggestive of viral infection presenting with sudden and quick death, and positive immunohistochemistry results, the case was closed as severe dengue fever. Clinicians must consider dengue as a diagnostic hypothesis among the indigenous population in Brazil. (Source: BMC Research Notes)
Source: BMC Research Notes - November 27, 2014 Category: Research Authors: Rafael SacramentoDeborah BragaFranciane SacramentoFernanda AraújoAntônio LimaMargarida PompeuDanielle LimaLuciano Cavalcanti Source Type: research

Reexpansion Pulmonary Edema after chest drainage for pneumothorax: a case report and literature overview
Conclusion RPE is characterized by rapidly progressive respiratory failure and tachycardia after intercostal chest drainage. Early recognition of signs and symptoms of RPE is important to initiate early management and allow for a favourable outcome. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - November 27, 2014 Category: Respiratory Medicine Source Type: research

Sleep disturbances in long-term immigrants with chronic mountain sickness: A comparison with healthy immigrants at high altitude
Publication date: 15 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 206 Author(s): Wei Guan , Qin Ga , Rong Li , Zhen-Zhong Bai , Tana Wuren , Jin Wang , Ying-Zhong Yang , Yu-Hong Li , Ri-Li Ge The aim of this study was to examine sleep disturbances in patients with chronic mountain sickness (CMS). The sleep of 14 patients with CMS and 11 healthy controls with or without sleep disorders (control N: without sleep disorders; control D: with sleep disorders) was studied by polysomnography. Hypopnea was the sleep disorder most commonly suffered by CMS patients and control D subjects. No major diffe...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Pleural liquid and kinetic friction coefficient of mesothelium after mechanical ventilation
Publication date: 15 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 206 Author(s): Francesca Bodega , Chiara Sironi , Cristina Porta , Luciano Zocchi , Emilio Agostoni Volume and protein concentration of pleural liquid in anesthetized rabbits after 1 or 3h of mechanical ventilation, with alveolar pressure equal to atmospheric at end expiration, were compared to those occurring after spontaneous breathing. Moreover, coefficient of kinetic friction between samples of visceral and parietal pleura, obtained after spontaneous or mechanical ventilation, sliding in vitro at physiological velocity unde...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Effects of acute hypercapnia with and without acidosis on lung inflammation and apoptosis in experimental acute lung injury
In conclusion, in this experimental ALI model, hypercapnia, regardless of acidosis, reduced lung inflammation and lung and kidney cell apoptosis. (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Evidence for respiratory neuromodulator interdependence after cholinergic disruption in the ventral respiratory column
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Clarissa Muere , Suzanne Neumueller , Justin Miller , Samantha Olesiak , Matthew R. Hodges , Lawrence Pan , Hubert V. Forster Reverse dialysis of the muscarinic receptor antagonist, atropine (ATR, 50mM), into the pre-Bötzinger Complex region of the ventral respiratory column (VRC) of awake and sleeping goats increases breathing frequency and serotonin (5-HT), substance P (SP), glycine, and GABA concentrations in the effluent dialysate. Herein, we report data from goats in which we reverse dialyzed 5mM ATR or spec...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Derivation of recruitment function from the pressure–volume curve in an acute lung injury model
This study aimed to determine the alveolar recruitment function by using a mathematical model from a pressure–volume curve (P–V curve). We assumed a lung model as V L = R(P) V 0 f(P), where R recruitment function is the fraction of recruited alveoli, V 0 is the resting lung volume at FRC of a fully recruited lung, and f(P) corresponds to the normalized compliance function of the lungs open to ventilation. Seven white rabbits were subjected to saline-lavage lung injury, and P–V curves were calculated using the slow inflation technique. We obtained the P–R curve from the P–V curve, and two curves were differently s...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Interactions of mechanically induced coughing and sneezing in cat
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Michal Simera , Ivan Poliacek , Boris Dobrolubov , Marcel Veternik , Jana Plevkova , Jan Jakus Mutual interactions of cough and sneeze were studied in 12 spontaneously breathing pentobarbitone anesthetized cats. Reflexes were induced by mechanical stimulation of the tracheobronchial and nasal airways, respectively. The amplitude of the styloglossus muscle EMG moving average during the sneeze expulsion was 16-fold higher than that during cough (p &lt;0.01). Larger inspiratory efforts occurred during coughing (p...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Changes in carotid body and nTS neuronal excitability following neonatal sustained and chronic intermittent hypoxia exposure
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): C.A. Mayer , C.G. Wilson , P.M. MacFarlane We investigated whether pre-treatment with neonatal sustained hypoxia (SH) prior to chronic intermittent hypoxia (SH+CIH) would modify in vitro carotid body (CB) chemoreceptor activity and the excitability of neurons in the caudal nucleus of the solitary tract (nTS). Sustained hypoxia followed by CIH exposure simulates an oxygen paradigm experienced by extremely premature infants who developed persistent apnea. Rat pups were treated with 5 days of SH (11% O2) from postnat...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Impact of short term forced oral breathing induced by nasal occlusion on respiratory function in mice
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Jiaxing Xie , Yin Xi , Qingling Zhang , Kefang Lai , Nanshan Zhong Inconsistent findings regarding the experimental nasal obstruction on respiratory functions in small animals have been reported. The purpose of this study was to investigate the impact of short term forced oral breathing on respiratory functions as well as the therapeutic implication of esophageal intubation in BALB/c mice. Thirty BALB/c mice were randomized equally to two groups: an experimental group and control group. Oral breathing was induced ...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

The protective effect of hypercapnia on ischemia-reperfusion injury in lungs
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Hana Mrazkova , Robert Lischke , Daniel Hodyc , Jan Herget Lifesaving therapy for patients with end-stage lung disease is lung transplantation. However, there are not enough available donors. A relatively new method of transplantation from non-heart-beating donors (NHBDs) allows the treatment of the lung outside the body and could increase the number of suitable lungs. We have focused on hypercapnic ventilation, which has the possibility of reducing reactive oxygen species damage. We used four experimental and two...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Diaphragm dysfunction caused by sphingomyelinase requires the p47phox subunit of NADPH oxidase
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Elaina R. Bost , Gregory S. Frye , Bumsoo Ahn , Leonardo F. Ferreira Sphingomyelinase (SMase) activity is elevated in inflammatory states and may contribute to muscle weakness in these conditions. Exogenous SMase depresses muscle force in an oxidant-dependent manner. However, the pathway stimulated by SMase that leads to muscle weakness is unclear. In non-muscle cells, SMase activates the Nox2 isoform of NADPH oxidase, which requires the p47phox subunit for enzyme function. We targeted p47phox genetically and phar...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Aerobic fitness influences cerebral oxygenation response to maximal exercise in healthy subjects
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Kahina Oussaidene , Fabrice Prieur , Semah Tagougui , Abdelbasset Abaidia , Regis Matran , Patrick Mucci The study examined whether the aerobic fitness level modifies the cerebral oxygenation response to incremental ramp exercise, and more specifically the decline in cerebral oxygenation from heavy exercise up to maximal intensities. 11 untrained ( V ˙ O 2 max 47.3±4.0mLmin−1 kg−1) and 13 endurance-trained ( V ˙ O 2 max 61.2±8.0mLmin−1 kg−1) healthy men performed a maximal ramp cycle exercise...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Orexin-B antagonized respiratory depression induced by sevoflurane, propofol, and remifentanil in isolated brainstem-spinal cords of neonatal rats
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Nobuo Umezawa , Hirofumi Arisaka , Shigeki Sakuraba , Takeo Sugita , Akiko Matsumoto , Yuki Kaku , Kazu-ichi Yoshida , Shun-ichi Kuwana Orexins (hypocretins) play a crucial role in arousal, feeding, and endocrine function. We previously reported that orexin-B activated respiratory neurons in the isolated brainstem-spinal cords of neonatal rats. We herein determined whether orexin-B antagonized respiratory depression induced by sevoflurane, propofol, or remifentanil. We recorded C4 nerve bursts as an index of inspi...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Role of posterior hypothalamus in hypobaric hypoxia induced pulmonary edema
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): R.K. Sharma , R.C. Choudhary , M.K. Reddy , A. Ray , K. Ravi To investigate the role of posterior hypothalamus and central neurotransmitters in the pulmonary edema due to hypobaric hypoxia, rats were placed in a high altitude simulation chamber (barometric pressure—294.4mmHg) for 24h. Exposure to hypobaric hypoxia resulted in increases in mean arterial blood pressure, renal sympathetic nerve activity, right ventricular systolic pressure, lung wet to dry weight ratio and Evans blue dye leakage. There was a signif...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Electrical activity of the diaphragm during progressive cycling exercise in endurance-trained men
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Mathias Krogh Poulsen , Lars Pilegaard Thomsen , Nicolai Lees Mifsud , Niels-Peter Brøchner Nielsen , René Melvad Jørgensen , Søren Kjærgaard , Dan Stieper Karbing The study aimed to investigate diaphragm respiratory drive modulation through electrical activity of the diaphragm (EADi) during progressive cycling in endurance-trained men (N =7) and to test day-to-day measurement reliability. Normalized EADi increased at exercise intensities from 40% workload (WL) to 70% and 85%WL but plateaued from 70% to 85% (...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

PGC-1α plays a major role in the anti-apoptotic effect of 15-HETE in pulmonary artery endothelial cells
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Jing Li , Yueming Zhang , Ying Liu , Tingting Shen , Hongyue Zhang , Yan Xing , Daling Zhu Peroxisome proliferator activated receptor gamma coactivator 1α (PGC-1α) has been confirmed as a key regulatory factor in pulmonary artery smooth muscle cells to mediate mitochondrial biogenesis and proliferation during hypoxia. However, the functional role of PGC-1α in hypoxic pulmonary artery endothelial cells (PAECs) still needs to be determined. In the present study, we found a marked elevation in the expression of PG...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

T3 supplementation affects ventilatory timing & glucose levels in type 2 diabetes mellitus model
In this study T2DM was induced in 20 female Sprague Dawley rats using Streptozotocin (STZ) and Nicotinamide (N). One of experimental STZ/N groups (N =10 per group) was treated with a low dose of triiodothyronine (T3). Blood glucose levels, metabolism and ventilation (in air and in response to hypoxia) were measured in the 3 groups. STZ/N-treated rats increased fasting blood glucose compared to control rats eight days and 2 months post-STZ/N injections indicating stable induction of T2DM state. Treatments had no effects on ventilation, metabolism or body weight. After one month of T3 supplementation, there were no physiolog...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Does menstrual cycle phase affect lung diffusion capacity during exercise?
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Joshua R. Smith , Kelly R. Brown , Jill D. Murphy , Craig A. Harms Resting lung diffusing capacity (DLCO) decreases during the early and late-follicular phases of the menstrual cycle presumably due to capillary blood volume (V C ) changes; however, it is not known if these differences exist during exercise. We hypothesized that DLCO would increase during the mid-luteal phase of the menstrual cycle due to increases in V C . Eight normally menstruating females (21.4±0.7yrs) were studied. Subjects completed a discon...
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research

Tanshinone IIA attenuates hypoxic pulmonary hypertension via modulating KV currents
Publication date: 1 January 2015 Source:Respiratory Physiology &amp; Neurobiology, Volume 205 Author(s): Lianhe Zheng , Min Wei , Manling Liu , Yi Liu , Mingqing Dong , Ying Luo , Pengtao Zhao , Haiying Dong , Wen Niu , Zhiqiang Yan , Zhichao Li The voltage-gated K+ (KV) channels play an essential role in the etiology of chronic hypoxic pulmonary hypertension (CH-PH).Tanshinone IIA (TIIA), a major active component of Salvia miltiorrhiza Bunge (S. miltiorrhiza), has many biological protective effects. In the present study, we investigated whether KV channels were responsible for the protective effect of TIIA on CH-PH....
Source: Respiratory Physiology and Neurobiology - November 27, 2014 Category: Respiratory Medicine Source Type: research