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High Chlamydia burden promotes TNF‐dependent reactive arthritis in SKG mice
Conclusion: In the susceptible SKG strain, Chlamydia‐induced reactive arthritis develops as a result of deficient intracellular pathogen control, with antigen‐specific TNF production upon dissemination of antigen, and TNF‐dependent inflammatory disease. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 26, 2015 Category: Rheumatology Authors: Athan C Baillet, Linda Rehaume, Helen Benham, Connor P O'Meara, Charles W Armitage, Roland Ruscher, Geraldine Brizard, Marina CG Harvie, Jared Velasco, Phillip Hansbro, John V. Forrester, Mariapia Degli‐Esposti, Kenneth W Beagley, Ranjeny Thomas Tags: Full Length Source Type: research

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients
Abstract Cystic fibrosis (CF) is the most common genetic life‐shortening condition in Caucasians. Despite being a multi‐organ disease, CF is classically diagnosed by symptoms of acute/chronic respiratory disease, with persistent pulmonary infections and mucus plugging of the airways and failure to thrive. These multiple symptoms originate from dysfunction of the CF transmembrane conductance regulator (CFTR) protein, a channel that mediates anion transport across epithelia. Indeed, establishment of a definite CF diagnosis requires proof of CFTR dysfunction, commonly through the so‐called sweat Cl− test. Many drug th...
Source: Journal of Internal Medicine - January 26, 2015 Category: Internal Medicine Authors: M. D. Amaral Tags: Review Source Type: research

Industry opinion on the likely routes of introduction of highly pathogenic porcine reproductive and respiratory syndrome into Australia from south‐east Asia
ConclusionThis study demonstrated that the expert elicitation technique was useful in rapidly assessing opinion from a large group of pig industry experts regarding exposure of pigs in Australia to HP‐PRRS virus. The results of this survey were used to direct a risk assessment of an incursion of HP‐PRRS. (Source: Australian Veterinary Journal)
Source: Australian Veterinary Journal - January 26, 2015 Category: Veterinary Research Authors: VJ Brookes, M Hernández‐Jover, P Holyoake, MP Ward Tags: PRODUCTION ANIMALS Source Type: research

Homozygous R1820W mutation results in recessive myosin storage myopathy: scapuloperoneal and respiratory weakness with dilated cardiomyopathy
• Our research family with MSM is the second family with recessive MYH7 mutation.• We identified a homozygous missense mutation in MYH7 exon 37.• One patient has an unusual combination of MSM and dilated cardiomyopathy.• The study emphasizes the genetic and clinical heterogeneity with MYH7 mutation. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - January 26, 2015 Category: Neurology Authors: Nur Yüceyar, Özgecan Ayhan, Hatice Karasoy, Aslıhan Tolun Tags: Case report Source Type: research

Non-Communicable Diseases And Adherence To Mediterranean Diet.
Authors: Antonio C, Valeria L Abstract Non-communicable diseases (NCDs) also known as chronic diseases last for a long time and progress generally slow. Major non-communicable diseases are cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. Wrong healthy lifestyles and food behaviours play an important role for determining such diseases. The changing of unhealthy behaviours or the maintenance of healthy lifestyles have an enormous value not only for individuals, with the reduction of diseases and longer life expectancy, but also for the entire community. Recent meta-analyses reported Medite...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 25, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

An Algorithmic Approach to Terminal Ventilator Withdrawal: Pilot Testing (FR416-D)
Terminal ventilator withdrawal entails the cessation of invasive mechanical ventilation to allow a natural death. There is little empirical evidence to guide the conduct of this common procedure. If the process is not well conducted, patients undergoing ventilator withdrawal are at very high risk for experiencing significant respiratory distress. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - January 25, 2015 Category: Palliative Care Authors: Margaret Campbell, Michael Mendez, Hossein Yarandi Source Type: research

Palliative Care in the Seriously Mentally Ill (FR452)
The seriously mentally ill (SMI) remain an underserved population in palliative care. The relationship between SMI and poor physical health is well documented. SMI have double the risk of dying from natural causes at any given age than the general population. They are at a higher risk of death from comorbid conditions such as cancer, cardiovascular disease, and respiratory and gastrointestinal illness, leading to an average reduced life expectancy of 8-15 years. Individuals with a psychiatric disorder are at increased risk for having a comorbid substance abuse disorder. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - January 25, 2015 Category: Palliative Care Authors: Leslie Blatt, Susan Crawford Source Type: research

Portuguese Journal of Pulmonology and Brazilian Journal of Pulmonology-"Aquele Abraço" ("A Great Big Hug")
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Gender differences in the perception of asthma and respiratory symptoms in a population sample of asthma patients in four Brazilian cities
CONCLUSIONS: Among women, asthma tends to be more symptomatic, as well as having a more pronounced effect on activities of daily living and on quality of life. OBJETIVO: Avaliar o impacto da asma em relação ao sexo em uma amostra populacional de pacientes asmáticos no Brasil. MÉTODOS: Foram entrevistados pessoalmente 400 pacientes asmáticos com idade > 12 anos de uma amostra probabilística nacional por contato telefônico nas cidades de São Paulo, Rio de Janeiro, Curitiba e Salvador. Os indivíduos responderam um questionário de 53 questões relacionadas...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial
CONCLUSIONS: The single-capsule combination of FLU/FOR showed non-inferiority to the BUD/FOR and FLU formulations regarding efficacy and safety, making it a new treatment option for persistent asthma. OBJETIVO: A fluticasona e o formoterol são efetivos no tratamento da asma. A terapia combinada é o tratamento de escolha quando o corticosteroide isolado não controla a asma. O objetivo deste estudo foi comparar a eficácia e segurança de formulações contendo budesonida/formoterol (BUD/FOR), fluticasona (FLU) e fluticasona/formoterol (FLU/FOR) em cápsula única sobre a função pulmonar em...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. OBJETIVO: Avaliar o papel do cateterismo de câmaras cardíacas direitas no diagnóstico de hipertensão arterial pulmonar (HAP). ...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Epidemiological aspects of and risk factors for wheezing in the first year of life
CONCLUSIONS: The prevalence of wheezing in the studied population was high (56.34%). The etiology was multifactorial, and the risk factors were intrinsic and extrinsic (respiratory tract infections, allergies, attending daycare, and early wheezing). The high prevalence and the intrinsic risk factors indicate the need and the opportunity for epidemiological and genetic studies in this population. In addition, mothers should be encouraged to prolong breastfeeding and to keep infants under six months of age out of daycare. OBJETIVO: Determinar a prevalência e os fatores de risco para sibilância...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Effects of home-based respiratory muscle training in children and adolescents with chronic lung disease
CONCLUSIONS: Home-based RMT appears to be an effective strategy for increasing respiratory muscle strength in children and adolescents with CLD or NMD, although it increased the ability to cough effectively only in those with NMD. OBJETIVO: A fraqueza muscular respiratória é uma repercussão funcional da doença pulmonar crônica (DPC). O objetivo deste estudo foi avaliar os efeitos do treinamento muscular respiratório (TMR) domiciliar em crianças e adolescentes com DPC ou doença neuromuscular (DNM). MÉTODOS: Estudo quasi-experimental com crianças e adolesce...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Correlates of experimentation with smoking and current cigarette consumption among adolescents
CONCLUSIONS: Current smoking was associated with a profile of socioeconomic correlates different from that associated with experimentation only. Our data (showing that current smoking was associated with having a friend who smokes, alcohol intake, and illicit drug use) suggest the need for comprehensive approaches to discourage substance use during adolescence. OBJETIVO: Analisar características sociais e estresse como correlatos de consumo de cigarros na adolescência. O principal objetivo foi identificar elementos que distingam adolescentes que experimentaram cigarros e não progrediram par...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Quantitative culture of endotracheal aspirate and BAL fluid samples in the management of patients with ventilator-associated pneumonia: a randomized clinical trial
CONCLUSIONS: In the context of this study, the management of VAP patients, based on the results of quantitative endotracheal aspirate cultures, led to similar clinical outcomes to those obtained with the results of quantitative BAL fluid cultures. OBJETIVO: Comparar a mortalidade em 28 dias e desfechos clínicos em pacientes com pneumonia associada à ventilação mecânica (PAVM) internados em UTI conforme a estratégia diagnóstica utilizada. MÉTODOS: Ensaio clínico randomizado prospectivo. Dos 73 pacientes incluídos no estudo, 36 e 37, respectivamente, foram ...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Facial pressure zones of an oronasal interface for noninvasive ventilation: a computer model analysis
CONCLUSIONS: The computer simulation results indicate that, in patients submitted to noninvasive ventilation with an OI, the probability of skin lesion is higher in the nasal bridge and paranasal regions. This methodology could increase the applicability of biomechanical research on noninvasive ventilation interfaces, providing the information needed in order to choose the interface that best minimizes the risk of skin lesion. OBJETIVO: Estudar os efeitos de uma interface oronasal (IO) durante a ventilação não invasiva usando um modelo computacional tridimensional (3D) com a capacidade de s...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Impact of the type of mask on the effectiveness of and adherence to continuous positive airway pressure treatment for obstructive sleep apnea
This study reviews theoretical concepts and questions the premise that all types of interfaces produce similar results. We revised the evidence in the literature about the impact that the type of CPAP interface has on the effectiveness of and adherence to OSA treatment. We searched the PubMed database using the search terms "CPAP", "mask", and "obstructive sleep apnea". Although we identified 91 studies, only 12 described the impact of the type of CPAP interface on treatment effectiveness (n = 6) or adherence (n = 6). Despite conflicting results, we found no consistent evidence that nasal pillows and oral masks alter OSA t...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Infected tracheal diverticulum: a rare association with alpha-1 antitrypsin deficiency
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

A six-minute step test protocol for the investigation of dyspnea
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Preserving the intercostal nerves as a goal in thoracotomy
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Liver injury may increase the risk of diazoxide toxicity: a case report
Conclusion: We hypothesize that low albumin level may increase the toxicity of diazoxide, possibly by increasing the free diazoxide concentration, as this compound is typically >90 % bound to plasma proteins. What is Known: • Diazoxide binds to plasma proteins >90 % and excreted in urine. • Dose adjustment is recommended in patients with impaired kidney functions. What is Ne...
Source: European Journal of Pediatrics - January 25, 2015 Category: Pediatrics Source Type: research

Maternally inherited diabetes is associated with a homoplasmic T10003C mutation in the mitochondrial tRNAGly gene
In this report, we investigate molecular pathogenic mechanism of a diabetes-associated homoplasmic mitochondrial tRNA mutation in a Han Chinese family with maternally transmitted diabetes mellitus. Of 10 adult matrilineal relatives, 5 individuals suffered from diabetes (4 subjects with only diabetes, one subject with both diabetes and hearing impairment), while other five matrilineal relatives (one with hearing loss) had glucose intolerance. The average age at onset of diabetes in matrilineal relatives was 50years. Molecular analysis of their mitochondrial genomes identified the novel homoplasmic T10003C mutation in the tR...
Source: Mitochondrion - January 25, 2015 Category: Biochemistry Source Type: research

Nanoparticulate CpG Immunotherapy in RAO‐Affected Horses: Phase I and IIa Study
Conclusion and Clinical ImportanceAdministration of a GNP‐bound CpG‐ODN formulation caused a potent and persistent effect on allergic and inflammatory‐induced clinical variables in RAO‐affected horses. This treatment, therefore, provides an innovative, promising, and well‐tolerated strategy beyond conventional symptomatic long‐term therapy and could serve as a model for asthma treatment in humans. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - January 25, 2015 Category: Veterinary Research Authors: J. Klier, B. Lehmann, S. Fuchs, S. Reese, A. Hirschmann, C. Coester, G. Winter, H. Gehlen Tags: Standard Article Source Type: research

Respiratory Pathogens in Québec Dairy Calves and Their Relationship with Clinical Status, Lung Consolidation, and Average Daily Gain
Conclusions and Clinical ImportanceResults suggested that nasopharyngeal carriage of M. bovis was detrimental to health and growth of dairy calves in small herds with a high incidence of BRD. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - January 25, 2015 Category: Veterinary Research Authors: D. Francoz, S. Buczinski, A.M. Bélanger, G. Forté, O. Labrecque, D. Tremblay, V. Wellemans, J. Dubuc Tags: Standard Article Source Type: research

Propofol dexmedetomidine versus propofol ketamine for anesthesia of endoscopic retrograde cholangiopancreatography (ERCP) (A randomized comparative study)
Conclusion Dexmedetomidine–propofol combination as TIVA during ERCP showed better intra-and post-procedural hemodynamic stability, less PONV, less postoperative cognitive dysfunctions and shorter recovery time when compared with ketamine–propofol combination. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - January 25, 2015 Category: Anesthesiology Source Type: research

Improvements in Sleep and Handwriting after Complementary Medical Intervention using Acupuncture, Applied Kinesiology, and Respiratory Exercises in a Nine-Year-Old ADHD Patient on Methylphenidate
Publication date: November–December 2014 Source:EXPLORE: The Journal of Science and Healing, Volume 10, Issue 6 Author(s): Friedrich Molsberger , Christa Raak , Christiane Witthinrich The case study reports on the effect of pharmacological, complementary, and alternative medicine including acupuncture, Applied Kinesiology, and respiratory exercises in a boy with attention-deficit hyperactivity disorder (ADHD) on methylphenidate. A nine-year-old male patient was referred to treatment with a three-year diagnosis of ADHD, sleeping troubles, and dissatisfaction with methylphenidate. Examination included Applied Kinesiology...
Source: EXPLORE: The Journal of Science and Healing - January 25, 2015 Category: Complementary Medicine Source Type: research

Cycloserine induced delirium during treatment of multi-drug resistant tuberculosis (MDR-TB)
Conclusion Patients with MDR-TB receiving Cycloserine should be closely monitored for neuropsychiatric side effects for early recognition and treatment. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - January 25, 2015 Category: Respiratory Medicine Source Type: research

Comparison of hospitalization among German coastal and deep sea fishermen
Conclusions Fishery is still an occupation which poses a high risk for malignant neoplasms and injuries. This is likely due to lifestyle and work-related factors. Further studies are needed to evaluate the different working and living conditions of coastal and deep sea fishermen. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - January 25, 2015 Category: Occupational Health Source Type: research

Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young–adult and old rats
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Luiz G.B. Michelini , Tiago R. Figueira , Edilene S. Siqueira-Santos , Roger F. Castilho Chronic and systemic treatment of rodents with rotenone, a classical inhibitor of mitochondrial respiratory complex I, results in neurochemical, behavioral, and neuropathological features of Parkinson’s disease. The aim of the present study was to evaluate whether brain mitochondria from old rats (24 months old) would be more susceptible to rotenone-induced inhibition of oxygen consumption and increased generation of H2O2 than mitochondria from young...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research

Management of Critical Asthma Syndrome During Pregnancy
Abstract One-third of pregnant asthmatics experience a worsening of their asthma that may progress to a critical asthma syndrome (CAS) that includes status asthmaticus (SA) and near-fatal asthma (NFA). Patients with severe asthma before pregnancy may experience more exacerbations, especially during late pregnancy. Prevention of the CAS includes excellent asthma control involving targeted early and regular medical care of the pregnant asthmatic, together with medication compliance. Spontaneous abortion risk is higher in pregnant women with uncontrolled asthma than in non-asthmatics. Should CAS occur during pregnan...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Infection in Severe Asthma Exacerbations and Critical Asthma Syndrome
Abstract In chronic persistent asthma and severe acute exacerbations of bronchial asthma, infectious agents are the predominant triggers that drive disease and airway pathobiology. In acute exacerbations of bronchial asthma (AEBA) including near fatal and fatal asthma, viral agents, particularly human rhinovirus-C, respiratory syncytial virus and influenza A appear to be the more prevalent and recurring threats. Both viral, and to a lesser extent bacterial agents, can play a role, and co-infection may also be present and worsen prognosis in hospitalized patients, placing a portion at risk for critical asthma synd...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Immunobiology of Critical Pediatric Asthma
Abstract Asthma is a heterogeneous disease with numerous clinical phenotypes. Severe asthma constitutes about 10 % of all cases of asthma. There is significant geographic and regional variation in the incidence and severity of asthma. Other important factors include gender, ethnicity, living environment, lifestyle, socioeconomic class, and pathophysiology. These factors can often be identified as either genetic or environmental influences on asthma severity. The immune system derangements in severe asthma are poorly understood. Many molecules and cell types have been implicated in severe asthma, including neutro...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Definition of Critical Asthma Syndromes
Abstract Urgent visits to the clinic and emergency department for acute severe asthma exacerbations are all too frequent. Existing national guidelines do not present consistent or specific recommendations for the evaluation and treatment of individual asthma patients in respiratory distress. In this vein, we propose the term "critical asthma syndrome" (CAS) to describe any child or adult who is at high risk for fatal asthma. Acute severe asthma, refractory asthma, status asthmaticus, and near-fatal asthma all describe CAS where physical exhaustion from the overwhelming work of breathing leads to respira...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Do all asthmatic patients have the same disease?
In this study, lung functional impairment was identified in infancy but was not accompanied by substantial airway pathology at tissue examination. The likelihood and severity of clinical asthma occurring during the follow-up period correlated with lung function at infancy but not with any pathologic finding. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2015 Category: Allergy & Immunology Authors: Marc H. Lavietes Tags: Guest editorial Source Type: research

Syncope as a manifestation of mast cell activation disorder
Anaphylaxis is a potentially fatal systemic allergic reaction that results from the abrupt release of basophil and mast cell mediators, such as histamine and tryptase. The clinical manifestations include skin, respiratory, and cardiovascular symptoms; however, a rapid decrease in blood pressure may be the unique manifestation. The most frequent causes of anaphylaxis are Hymenoptera venom, foods, and drugs.1 Idiopathic anaphylaxis is considered in case of unknown cause.2 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2015 Category: Allergy & Immunology Authors: Carolina Perales Chordá, Sandra Fabregat Nebot, Pedro Moral Moral, Isidro Jarque Ramos, Dolores Hernández Fernandez de Rojas Tags: Letter Source Type: research

Risk of adverse events among older adults following co-prescription of clarithromycin and statins notmetabolized by cytochrome P450 3A4.
 Among older adults taking a statin not metabolized by CYP3A4 (rosuvastatin/pravastatin/fluvastatin), co-prescription of clarithromycin versus azithromycin was associated with a modest but statistically significant increase in the 30-day absolute risk of adverse outcomes, including AKI and admission with hyperkalemia. : Treatment of Kidney Transplant Recipients With ACEi/ARB and Risk of Respiratory Tract Cancer: A Collaborative Transplant Study Report Novartis announces termination of ALTITUDE study Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus (Source: Nephrology Now)
Source: Nephrology Now - January 24, 2015 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Internal Medicine for Nephrologists Source Type: research

Exercise Training for Management of Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Conclusions and relevance Exercise training improves cardio-respiratory fitness, pain-free and total flat-ground walking distances, as well as graded treadmill performance in PAD. Exercise prescriptions for PAD may consider arm cranking as well as lower limb exercise, possibly at short vigorous intensity intervals, but only to a threshold of mild pain. (Source: Sports Medicine)
Source: Sports Medicine - January 24, 2015 Category: Sports Medicine Source Type: research

Respiratory Virus (RV) from Broncho Alveolar Lavage (BAL) Prior to Hematopoietic Cell Transplantation (HCT): A Strong Predictor for Allo-Immune Mediated Lung Syndromes (allo-LS)
This study evaluates the impact of RV RNA-DNA-positivity pre-HCT from NPA or BAL respectively on the occurrence of allo-LS. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Birgitta Versluys, Marc Bierings, Caroline A. Lindemans, Kors Ent vd, Tom Wolfs, Jean Luc Murk, Jaap-Jan Boelens Tags: GVH/GVL Source Type: research

Human Metapneumovirus Infections in Hematopoietic Cell Transplant Recipients: Seasonality and Factors Associated with Progression to Lower Respiratory Tract Disease
Human metapneumovirus (HMPV) is a respiratory virus that was first identified in 2001. In immunocompromised hosts, HMPV upper respiratory tract infection (URI) can progress to lower respiratory tract disease (LRD). The mortality rate after HMPV LRD in hematopoietic cell transplant (HCT) recipients is as high as 40%, similar to that of respiratory syncytial virus, a structurally similar respiratory virus. To date, most studies in HCT recipients are of very small sample size, and minimal data exists on risk factors for LRD. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Sachiko Seo, Ted Gooley, Jane M. Kuypers, Zach Stednick, Keith R. Jerome, Janet A. Englund, Michael J. Boeckh Tags: Supportive Care Source Type: research

Oral Ribavirin for the Treatment of Respiratory Syncytial Virus Infection in Allogeneic Stem Cell Transplant Recipients-Utility of the Immunodeficiency Scoring Index for Risk Stratification
Respiratory syncytial virus (RSV) infection is a serious complication post allogeneic stem cell transplant. Aerosolized ribavirin is a commonly used therapy; however, oral ribavirin is an alternative with many advantages. There is paucity in literature regarding treatment outcomes using the oral form. Recently, the immunodeficiency scoring index (ISI) was derived from the largest reported RSV cohort to date using aerosolized ribavirin. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Moussab Damlaj, Gabriel Bartoo, Desire Gijima, Shahrukh Hashmi, Mark R. Litzow, William Hogan, Mrinal Patnaik Tags: Late Effects/Quality of Life/Psychosocial Issues Source Type: research

Good Outcome of RSV Infection without Ribavirin Treatment in Pediatric Bone Marrow Transplantation
Clinicians commonly use inhaled ribavirin to treat HSCT recipients with Respiratory Syncytial Virus (RSV); however, limited data exist to support this therapy. We evaluated 349 consecutive patients transplanted between June, 2008 and December, 2013. Eighteen (5.2%) pediatric and young adult patients (6 months to 25 years of age) developed an RSV infection. Fifteen (83%) patients presented with an upper respiratory tract infection (URTI) identified a median of 151 (range 3 – 621) days post-HSCT and 3 (17%) presented with, or progressed to, a lower respiratory tract infection (LRTI) identified a median of 33 (range 10 – ...
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Javier El-Bietar, Adam Stuart Nelson, Gregory Wallace, Christopher E. Dandoy, Sonata Jodele, Kasiani C. Myers, Stella M. Davies, Lara Danziger-Isakov Tags: Pediatric Disorders Source Type: research

Forced Deflation PFT: A Novel Method to Evaluate Lung Function in Infants and Young Children
We describe use of forced deflation PFT (dPFT), a novel technique for assessment of lung function in a series of infants and young children and those unable to perform cooperative testing. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Rakesh K. Goyal, Azada Ibrahimova, Maria L. Escolar, Paul Szabolcs, Mark Vander Lugt, Randy M. Windreich, Daniel J. Weiner Tags: Pediatric Disorders Source Type: research

Trend, Risk Factors and Outcome of Respiratory Syncytial Viral Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Multi-Institutional Review
Respiratory syncytial virus (RSV) is a common cause of serious respiratory infections in hematopoietic stem-cell transplant (HSCT) recipients. Infection of the upper airways may progress to lower airway leading to mortality especially in young children. In spite of being a common infection, there is paucity of data about its prevalence, efficacy of prevention, risk factors for infection and mortality in pediatric HSCT recipients. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Ram Kalpatthi, Matt Hall, Nazia Tabassum, Nancy Shreve, Leigh Casey, Jignesh Dalal Tags: Pediatric Disorders Source Type: research

Late Onset Pulmonary Arterial Hypertension after Successful HSCT for Familial HLH
We report a case of occult pulmonary hypertension that developed 3 years after HSCT for FHLH. The patient was born at 28 weeks with a NICU course consisting of mild respiratory distress syndrome and unilateral grade II intraventricular hemorrhage. At 2.5 months of age, he developed fevers, splenomegaly, progressive pancytopenia, hypofibrinogenemia, hyperferritinemia, and bone marrow hemophagocytosis. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Andrea R. Whitfield, Michael Caplan, Ryan Butts, Susan E. Presnell, Michelle Hudspeth Tags: Pediatric Disorders Source Type: research

Incidence and Outcome of Rhinovirus in Children Undergoing Hematopoietic Stem Cell Transplantation
Human rhinovirus (HRV) is well known to cause upper or lower respiratory tract infection (URTI/LRTI) and is associated with increased morbidity and mortality in immunocompromised adults such as those with cancer or those undergoing hematopoietic stem cell transplantation (HSCT). Asymptomatic children who are about to undergo HSCT with a positive respiratory viral panel (RVP) pose a special challenge and create a dilemma for providers when deciding whether to move forward with HSCT in patients with active viral disease. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: James DeMasi, Victor Aquino, Tiffany Simms-Waldrip, Andrew Young Koh, Sharon Holmes Tags: Supportive Care Source Type: research

Determinants of Physical Activity Levels in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Respiratory and skeletal muscle strength and submaximal exercise capacity and physical activity levels are known to be reduced in a significant percentage of patients prior to hematopoietic stem cell transplantation (HSCT). However, determinants of physical activity levels of HSCT recipients have not been investigated so far. The aim of this study was to determine the role of physical activity levels in HSCT recipients. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Gulsan Turkoz Sucak, Meral Bosnak Guclu, Zeynep Aribas, Gulsah Bargi, Elif Sakizli, Sahika Zeynep Aki, Zeynep Arzu Yegin Tags: Supportive Care Source Type: research

Identification of Respiratory Viral Infection in Hematopoietic Stem Cell Transplant Recipients - Impact on Non Relapse Mortality
Infection is the leading cause of non-relapse mortality (NRM) in allo-HSCT. A community respiratory virus infection (RVI) screening program was instituted at our center from 5/2010 in order to prevent nosocomial infection, assist in cohorting strategies and minimize RV during allo-HSCT. The impact of RVI screening on respiratory-related NRM was assessed. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Louise Imlay-Gillespie, Meera Srinivasan, Kelly Wong, Christopher Arthur, Keith Fay, Ian Kerridge, William Stevenson, Matthew Greenwood Tags: Allogeneic Transplants Source Type: research