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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Integrative 'Omic Analysis of Experimental Bacteremia Identifies a Metabolic Signature that Distinguishes Human Sepsis from SIRS.
Conclusion: A model of sepsis based on reciprocal metabolomic and transcriptomic data was developed in primates and validated in two human patient cohorts. It is anticipated that the identified parameters will facilitate early diagnosis and management of sepsis. PMID: 25054455 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2014 Category: Respiratory Medicine Authors: Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler Jr VG, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA Tags: Am J Respir Crit Care Med Source Type: research

Ultrastructure of Human Tracheal Smooth Muscle from Asthmatic and Non-asthmatic Subjects: Standardized Methods for Comparison.
Abstract A characteristic feature of asthma is exaggerated airway narrowing, termed airway hyperresponsiveness (AHR) due to contraction of airway smooth muscle (ASM). Although smooth muscle-specific asthma susceptibility genes have been identified, it is not known whether asthmatic ASM is phenotypically different from non-asthmatic ASM in terms of subcellular structure or mechanical function. The present study is the first to systematically quantify, using electron microscopy, the ultrastructure of tracheal SM from asthmatic and non-asthmatic subjects. Methodological details concerning tissue sample preparation, ul...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Syyong HT, Pascoe CD, Zhang J, Arsenault BA, Solomon D, Elliott WM, Hackett TL, Walker DC, Paré PD, Seow CY Tags: Am J Respir Cell Mol Biol Source Type: research

Role of miR-150 and Glycoprotein Non-metastatic Melanoma Protein B in Angiogenesis During Hyperoxia-induced Neonatal Lung Injury.
Conclusions. GPNMB plays an important role in angiogenesis during hyperoxia-injury. Treatment with GPNMB may offer a novel therapeutic approach in reducing pathologic complications in bronchopulmonary dysplasia. PMID: 25054912 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Narasaraju T, Shukla D, More S, Huang C, Zhang L, Xiao X, Liu L Tags: Am J Respir Cell Mol Biol Source Type: research

Interaction With Epithelial Cells Modifies Airway Macrophage Response to Ozone.
Abstract The initial innate immune response to ozone (O3) in the lung is orchestrated by structural cells, such as epithelial cells, and resident immune cells, such as airway macrophages (Mac). We developed an epithelial cell-Mac co-culture model to investigate how epithelial cell-derived signals affect Mac response to O3. Mac from the bronchoalveolar lavage (BAL) of healthy volunteers were co-cultured with the human bronchial (16HBE) or alveolar (A549) epithelial cell lines. Co-cultures, Mac monocultures, and epithelial cell monocultures were exposed to O3 or air and Mac immunophenotype, phagocytosis, and cytotoxi...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Bauer RN, Müller L, Brighton LE, Duncan KE, Jaspers I Tags: Am J Respir Cell Mol Biol Source Type: research

Pigment Epithelium-derived Factor Mediates Impaired Lung Vascular Development in Neonatal Hyperoxia.
Abstract BPD is a chronic lung disease of preterm infants characterized by arrested microvascularization and alveolarization. Studies show the importance of pro-angiogenic factors for alveolarization, but the importance of anti-angiogenic factors is unknown. We proposed that hyperoxia increases the potent angiostatin Pigment Epithelium-derived Factor (PEDF) in neonatal lungs, inhibiting alveolarization and microvascularization. Wild type (WT) and PEDF (-/-) mice were exposed to room air (RA) or 0.9 FiO2 from postnatal day 5 to 13. PEDF protein was increased in hyperoxia compared to RA-exposed lungs (P<0.05). In ...
Source: Am J Respir Cell Mol... - July 23, 2014 Category: Respiratory Medicine Authors: Chetty A, Bennett M, Dang L, Nakamura D, Cao GJ, Mujahid S, Volpe M, Herman I, Becerra SP, Nielsen HC Tags: Am J Respir Cell Mol Biol Source Type: research

Mucin 1 (MUC1) signalling contributes to increase the resistance to cell death in human bronchial epithelial cells exposed to nickel acetate.
Abstract We have previously reported that nickel acetate (Ni(2+)), a well-known human carcinogenic agents, differentially affected apoptosis in two different airway epithelial cell lines derived from the human respiratory tract (A549 and Beas-2B, respectively), suggesting a potential involvement of epidermal growth factor receptor (EGFR)/Neu receptors in mediating this effect. Since ErbBs are closely associated to Mucin 1 (MUC1), a glycoprotein component of airway mucus that is overexpressed in lung tumors, we have investigated the role of this signaling system in the survival response of airway epithelial cells ag...
Source: Biometals - July 23, 2014 Category: Biochemistry Authors: Castorina A, Giunta S Tags: Biometals Source Type: research

Analysis of Three-Dimensional Aerosol Deposition in Pharmacologically Relevant Terms: Beyond Black or White ROIs
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

In Vitro Performance of Spacers for Aerosol Delivery during Adult Mechanical Ventilation
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

The Effect of Beclometasone Dipropionate/Formoterol Extra-Fine Fixed Combination on the Peripheral Airway Inflammation in Controlled Asthma
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - July 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Prospective External Validation of a Predictive Score for Postoperative Pulmonary Complications
Background: No externally validated risk score for postoperative pulmonary complications (PPCs) is currently available. The authors tested the generalizability of the Assess Respiratory Risk in Surgical Patients in Catalonia risk score for PPCs in a large European cohort (Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe). Methods: Sixty-three centers recruited 5,859 surgical patients receiving general, neuraxial, or plexus block anesthesia. The Assess Respiratory Risk in Surgical Patients in Catalonia factors (age, preoperative arterial oxygen saturation in air, acute respiratory i...
Source: Anesthesiology - July 22, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Clinical Science Source Type: research

Thoraco‐abdominal asymmetry and asynchrony in congenital diaphragmatic hernia
ConclusionsIn overall CDH patients a reduced action of the treated (left) hemi‐diaphragm is evident. In patients treated by primary suture, a compensatory action of the right side allows to reach a normal total diaphragmatic displacement and a proper contribution of the whole diaphragm to tidal volume. In patients treated by diaphragmatic patch, instead, thoraco‐abdominal asynchronies are prevented. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 22, 2014 Category: Respiratory Medicine Authors: Marianna Laviola, Andrea Zanini, Rita Priori, Francesco Macchini, Ernesto Leva, Maurizio Torricelli, Clara Ceruti, Andrea Aliverti Tags: Original Article: Other Source Type: research

Illness perception in people with chronic obstructive pulmonary disease
Illness perception (IP) concerns how patients evaluate living with a disease. To get a broader understanding of IP in patients with chronic obstructive pulmonary disease (COPD), we investigated whether breathlessness is an important precursor of IP and whether IP in its turn is related to mental health, physical health and global quality of life (QOL). One hundred and fifty‐four patients with COPD participated in a cross‐sectional survey. Participants underwent pulmonary function testing, provided socio‐demographic and clinical information, and completed the following standardized instruments: Brief Illness Perceptio...
Source: Scandinavian Journal of Psychology - July 22, 2014 Category: Psychiatry & Psychology Authors: Christine Råheim Borge, Torbjørn Moum, Martha Puline Lein, Elise Lynn Austegard, Astrid Klopstad Wahl Tags: Health and Disability Source Type: research

Pierre Robin Sequence: A Perioperative Review.
Abstract The clinical triad of micrognathia (small mandible), glossoptosis (backward, downward displacement of the tongue), and airway obstruction defines the Pierre Robin sequence (PRS). Airway obstruction and respiratory distress are clinical hallmarks. Patients may present with stridor, retractions, and cyanosis. Severe obstruction results in feeding difficulty, reflux, and failure to thrive. Treatment options depend on the severity of airway obstruction and include prone positioning, nasopharyngeal airways, tongue lip adhesion, mandibular distraction osteogenesis, and tracheostomy. The neonate and infant with P...
Source: Anesthesia and Analgesia - July 22, 2014 Category: Anesthesiology Authors: Cladis F, Kumar A, Grunwaldt L, Otteson T, Ford M, Losee JE Tags: Anesth Analg Source Type: research

Ginseng Diminishes Lung Disease in Mice Immunized with Formalin-Inactivated Respiratory Syncytial Virus After Challenge by Modulating Host Immune Responses
Journal of Interferon & Cytokine Research , Vol. 0, No. 0. (Source: Journal of Interferon)
Source: Journal of Interferon - July 22, 2014 Category: Research Tags: article Source Type: research

80 Year Old Male: Fall
A previously well 80-year-old experienced a fall at his home where he lives alone. He was walking from the living room to the kitchen when suddenly he found himself on the ground, which he attributes to tripping on the runner rug in the hallway. “My son has been telling me to get rid of that thing for years but I don’t like getting the carpet dirty.” Unfortunately he injured his hip in the process and wasn’t able to get to the phone to call for assistance, spending two days on the floor until the Meals on Wheels volunteer came by. Skin is cool and dry and his mucous membranes are dry. He has severe ...
Source: EMS 12-Lead - July 22, 2014 Category: Cardiology Authors: Vince DiGiulio Tags: 12 lead ecg Arrhythmias Cases AV Block bifascicular block bradycardia Heart Block LAFB Mobitz II RBBB Syncope type II Source Type: research

[Comment] Challenges to global pandemic mortality estimation
In May 2012, we published estimates of global mortality associated with influenza A H1N1 pandemic 2009 (H1N1pdm09) virus infection during the first year of virus circulation in each country. In November, 2013, Simonsen and colleagues also presented estimates of global H1N1pdm09-associated mortality during April, 2009, to December, 2009. Although different methods were used, the two studies reached reassuringly similar conclusions. We estimated 201 000 respiratory deaths, and Simonsen and colleagues estimated 188 000 respiratory deaths; most estimated deaths in both studies were in people younger than 65 years; and in f...
Source: The Lancet Infectious Diseases - July 22, 2014 Category: Infectious Diseases Authors: Marc-Alain Widdowson, A Danielle Iuliano, Fatimah S Dawood Tags: Comment Source Type: research

Second-hand tobacco smoke and children
Cigarette smoke contains harmful chemicals with hazardous adverse effects on almost every organ in the body of smokers as well as of nonsmokers exposed to environmental tobacco smoke (ETS). There has been increasing interest in the effects of passive smoking on the health of children. In order to detect the magnitude of passive smoking in children, parental questionnaires, measuring nicotine and cotinine body levels, and evaluating expired carbon monoxide (CO) concentrations, have been used. Passive smoking causes respiratory illness, asthma, poor growth, neurological disorders, and coronary heart diseases. Herein, we focu...
Source: Toxicology and Industrial Health current issue - July 22, 2014 Category: Toxicology Authors: Al-Sayed, E. M., Ibrahim, K. S. Tags: Articles Source Type: research

A role for the mitochondrial-associated protein p32 in regulation of trophoblast proliferation
In this study, we sought to examine the expression and function of p32 in the human placenta. p32 was highly expressed in the syncytiotrophoblast, the underlying cytotrophoblast (CTB), the vascular endothelium and by a proportion of cells in the villous stroma in first trimester and term placenta. p32 mRNA and protein expression was significantly higher in the first trimester of pregnancy than at term, and expression in the trophoblast was significantly reduced in placentas from women with fetal growth restriction (FGR). Small interfering RNA (siRNA)-mediated knockdown of p32 in term placental explants significantly reduce...
Source: Molecular Human Reproduction - July 22, 2014 Category: Molecular Biology Authors: Matos, P., Horn, J. A., Beards, F., Lui, S., Desforges, M., Harris, L. K. Tags: Articles Source Type: research

IMRT sparing of normal tissues in locoregional treatment of breast cancer
Conclusion: IMRT-HT for locoregional breast radiation is very well tolerated with minimal acute or moderately-late side effects. Cardiac and respiratory tests did not show any strong evidence of significant treatment related abnormalities.Trial registration: clinicaltrials.gov: NCT00508352. (Source: Radiation Oncology)
Source: Radiation Oncology - July 22, 2014 Category: Cancer & Oncology Authors: Jean-Michel CaudrelierJoanne MengBernd EscheLaval GrimardTerrence RuddyKayvan Amjadi Source Type: research

Application of a Monte Carlo lung dosimetry code to the inhalation of thoron progeny
To determine radiation doses incurred by inhaled thoron progeny, the Monte Carlo radon progeny lung dosimetry code IDEAL-DOSE was adapted to the inhalation of thoron progenies, comprising the alpha-emitting nuclides 216Po, 212Bi and 212Po. Dose calculations for defined exposure conditions yielded a dose conversion coefficient (DCC) of 4.6 mSv WLM–1 or 94.2 nSv (Bq h m–3)–1 when compared with a DCC of 3.8 mSv WLM–1 if based on the International Commission on Radiological Protection Human Respiratory Tract Model. Bronchial doses were computed for different thoron progenies exposure conditions measured...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Hofmann, W., Winkler-HeiI, R., Truta, L. A., Tschiersch, J. Tags: Health effects of radon Source Type: research

Radon dose assessment in underground mines in Brazil
Underground miners are internally exposed to radon, thoron and their short-lived decay products during the mineral processing. There is also an external exposure due to the gamma emitters present in the rock and dust of the mine. However, the short-lived radon decay products are recognised as the main radiation health risk. When inhaled, they are deposited in the respiratory system and may cause lung cancer. To address this concern, concentration measurements of radon and its progeny were performed, the equilibrium factor was determined and the effective dose received was estimated in six Brazilian underground mines. The r...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Santos, T. O., Rocha, Z., Cruz, P., Gouvea, V. A., Siqueira, J. B., Oliveira, A. H. Tags: Health effects of radon Source Type: research

Calibration of CR-39-based thoron progeny device
This study deals with the calibration of the track detector measurement method suitable for measuring thoron progenies using different devices with measurement techniques capable of measuring several progenies (Pylon AB5 and WLx, Sarad EQF 3220). The calibration factor values related to the thoron progeny monitors, the measurement uncertainty, reproducibility and other parameters were found using the calibration chamber. In the future, the effects of the different parameters (aerosol distribution, etc.) will be determined. (Source: Radiation Protection Dosimetry)
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Fabian, F., Csordas, A., Shahrokhi, A., Somlai, J., Kovacs, T. Tags: Methods of measurement-devices, metrological aspects Source Type: research

Size distribution of radon decay products in the range 0.1-10 nm
Information about the size distribution of radioactive aerosols in nanometre range is essential for the purposes of air contamination monitoring, dose assessment to respiratory tract and planning of protective measures. The diffusion battery, which allows capturing particles in the size range of 0.1–10 nm, has developed. Interpreting data obtained from diffusion battery is very complex. The method of expectation maximisation by Maher and Laird was chosen for indirect inversion data. The experiments were performed in the box with equivalent equilibrium concentration of radon in the range of 7000–10 000 Bq m&ndas...
Source: Radiation Protection Dosimetry - July 22, 2014 Category: Radiology Authors: Zhukovsky, M., Rogozina, M., Suponkina, A. Tags: Methods of measurement-devices, metrological aspects Source Type: research

HrtBA and menaquinones control haem homeostasis in Lactococcus lactis
Summary Lactococcus lactis is a fermenting Gram‐positive bacterium widely used for production of dairy products. Lacking haem biosynthesis genes, L. lactis can still shift to an energetically favourable respiratory metabolism by activating a terminal cytochrome bd oxidase when haem is added to an aerated culture. Haem intracellular homeostasis is mediated by the hrtRBA operon encoding the conserved membrane HrtBA haem efflux permease and the unique intracellular haem sensor and regulator, HrtR. Here we report that membrane‐associated menaquinones (MK) favour the accumulation of reduced haem in membranes. An oxidative e...
Source: Molecular Microbiology - July 22, 2014 Category: Microbiology Authors: Laetitia Joubert, Aurélie Derré‐Bobillot, Philippe Gaudu, Alexandra Gruss, Delphine Lechardeur Tags: Research Article Source Type: research

Icatibant, an inhibitor of bradykinin receptor 2, for hereditary angioedema attacks: prospective experimental single-cohort study.
CONCLUSION: HAE type I patients who received icatibant responded promptly; most achieved improved symptom severity within 30 minutes. Local adverse events occurred in 75% of the patients. PMID: 25054967 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - July 22, 2014 Category: Journals (General) Authors: Campos RA, Valle SO, França AT, Cordeiro E, Serpa FS, Mello YF, Malheiros T, Toledo E, Mansour E, Fusaro G, Grumach AS Tags: Sao Paulo Med J Source Type: research

Spillover of Cytokines and Reactive Oxygen Species in Ventilator-Induced Lung Injury Associated With Inflammation and Apoptosis in Distal Organs.
CONCLUSIONS: High VT ventilation induces VILI and is associated with inflammation and apoptosis in distal organs. Up-regulation of reactive oxygen species and cytokines in VILI is associated with systemic inflammatory responses. Kidney tissue appears to be more vulnerable than heart and liver tissues following VILI. PMID: 25053831 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Liu YY, Chiang CH, Chuang CH, Liu SL, Jheng YH, Ryu JH Tags: Respir Care Source Type: research

Filamin A Mutation May Be Associated With Diffuse Lung Disease Mimicking Bronchopulmonary Dysplasia in Premature Newborns.
We present the clinical course of a premature newborn with a complicated neonatal respiratory course that was initially thought to be related to BPD, but it did not respond to the typical therapies for this condition. Due to the findings of periventricular nodular heterotopia, the diagnosis of a filamin A gene mutation was eventually made, which explained the respiratory pathology of this patient. When time of onset and clinical course do not correlate with typical BPD, one should consider alternative diagnoses in premature infants, including neonatal diffuse lung disease. PMID: 25053830 [PubMed - as supplied by publis...
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Lord A, Shapiro AJ, Saint-Martin C, Claveau M, Melançon S, Wintermark P Tags: Respir Care Source Type: research

Unilateral Hyperlucent Lung Associated With Bronchial Atresia Mimicking Swyer-James Syndrome.
PMID: 25053829 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Ando M, Miyazaki E, Fujisaki H, Nureki SI, Kadota JI Tags: Respir Care Source Type: research

Respiratory Failure Secondary to Relapsing Polychondritis.
PMID: 25053828 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Badireddi S, Siddiqui MF, Boddu NJ Tags: Respir Care Source Type: research

Administration of supplemental L-tyrosine with phenelzine
Hinz M, Stein A, Cole T, Ryan P (Source: International Journal of COPD)
Source: International Journal of COPD - July 21, 2014 Category: Respiratory Medicine Source Type: research

Degree of extraversion and physiological responses to physical pain and sadness
Extraversion is a personality frequently discussed as one of the strongest and most consistent factors that relates to individual subjective wellbeing. The goal of this study was to better understand how people with varying degrees of extraversion psychologically and physiologically respond differently to unpleasant circumstances. Emotional responses (e.g., levels of intensity, valence, and arousal) were assessed in determining the sensitivity level to negative stimuli that were specifically designed to provoke physical pain and sadness emotion. Physiological changes (e.g., heart rate (HR), blood volume pulse (BVP), and re...
Source: Scandinavian Journal of Psychology - July 21, 2014 Category: Psychiatry & Psychology Authors: Mi‐Sook Park, Kyung Hwa Lee, Sunju Sohn, Jin‐Sup Eom, Jin‐Hun Sohn Tags: Personality and Social Psychology Source Type: research

Anti‐nociceptive and sedative effects of romifidine, tramadol and their combination administered intravenously slowly in ponies
ConclusionTramadol combined with romifidine at the stated doses proved an effective sedative and anti‐nociceptive combination in ponies, with no unacceptable behavioural or physiologic side effects. Clinical relevanceSlow controlled administration of tramadol should reduce the occurrence of adverse behavioural side effects. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Giovanna L Costa, Santo Cristarella, Marco Quartuccio, Claudia Interlandi Tags: Short Communication Source Type: research

Antinociceptive effect of buprenorphine and evaluation of the nociceptive withdrawal reflex in foals
Conclusion and clinical relevanceThese findings indicate that buprenorphine has antinociceptive effect in foals. Opioid side effects often recognized in adult horses also occur in foals. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Åse I Risberg, Claudia Spadavecchia, Birgit Ranheim, Eli HS Hendrickson, Andreas Lervik, Henning A Haga Tags: Research Paper Source Type: research

A comparison of cardiopulmonary function, recovery quality, and total dosages required for induction and total intravenous anesthesia with propofol versus a propofol‐ketamine combination in healthy Beagle dogs
Conclusions and clinical relevanceTotal intravenous anesthesia in healthy dogs with ketamine and propofol in a 1:1 mg mL−1 combination resulted in significant propofol dose reduction, higher HR, improved MAP, no difference in recovery quality, but more significant respiratory depression compared to propofol alone. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Martin J Kennedy, Lesley J Smith Tags: Research Paper Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 21, 2014 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Assessment of two different types of bias affecting the results of outcome-based evaluation in undergraduate medical education
Conclusions: Given the small effect sizes, using thentests appears to be equivalent to using true pretest ratings. Item presentation in the posttest does not significantly impact on results. (Source: BMC Medical Education)
Source: BMC Medical Education - July 21, 2014 Category: Universities & Medical Training Authors: Sarah SchiekirkaSven AndersTobias Raupach Source Type: research

Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study
Conclusions: Early deep sedation is associated with adverse outcomes and constitutes an independent predictor of hospital mortality in mechanically ventilated patients. (Source: Critical Care)
Source: Critical Care - July 21, 2014 Category: Intensive Care Authors: Lilian TanakaLuciano AzevedoMarcelo ParkGuilherme SchettinoAntonio NassarAlvaro Réa-NetoLuana TannousVicente de Souza-DantasAndré TorellyThiago LisboaClaudio PirasFrederico CarvalhoMarcelo MaiaFabio GianiniFlavia MachadoFelipe Dal-PizzolAlexandre de Car Source Type: research

Physiological response to the 6-minute walk test in chronic heart failure patients versus healthy control subjects
Conclusions Above 500 m, 6MWD becomes less sensitive to any increase in peakVO2. Furthermore, CHF patients and healthy control subjects exercise respectively at maximal and high VO2, but below the anaerobic threshold (as assessed by a CPET) during the 6-min walk test. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - July 21, 2014 Category: Cardiology Authors: Deboeck, G., Muylem, A. V., Vachiery, J. L., Naeije, R. Tags: Original scientific paper Source Type: research

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research

Suboptimal nutrition in moderately preterm infants
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Kelly Brown, Mark J. Johnson, Alison A. Leaf Tags: Short Communication Source Type: research

Re: Tramadol can selectively manage moderate pain in children following European advice limiting codeine use
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Hossein Hassanian‐Moghaddam Tags: Letter Source Type: research

Tiotropium versus placebo for chronic obstructive pulmonary disease.
CONCLUSIONS: This review shows that tiotropium treatment was associated with a significant improvement in patients' quality of life and it reduced the risk of exacerbations, with a number needed to treat to benefit (NNTB) of 16 to prevent one exacerbation. Tiotropium also reduced exacerbations leading to hospitalisation but no significant difference was found for hospitalisation of any cause or mortality. Thus, tiotropium appears to be a reasonable choice for the management of patients with stable COPD, as proposed in guidelines. The trials included in this review showed a difference in the risk of mortality when compared ...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Karner C, Chong J, Poole P Tags: Cochrane Database Syst Rev Source Type: research

Endovascular treatment for ruptured abdominal aortic aneurysm.
CONCLUSIONS: The conclusions of this review are currently limited by the paucity of data. From the data available there is no difference in the outcomes evaluated in this review between eEVAR and open repair, specifically 30-day mortality. Not enough information was provided for complications in order to make a well informed conclusion at this time. Long-term data are lacking for both survival and late complications. More high quality, randomised controlled trials comparing eEVAR and open repair for the treatment of RAAA are needed in order to better understand if one method is superior to the other, or if there is no diff...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Badger S, Bedenis R, Blair PH, Ellis P, Kee F, Harkin DW Tags: Cochrane Database Syst Rev Source Type: research

Extracorporeal Life Support in Critically Ill Adults.
Abstract Extracorporeal life support (ECLS) has become increasingly popular as a salvage strategy for critically ill adults. Major advances in technology and the severe acute respiratory distress syndrome (ARDS) that characterized the 2009 influenza A (H1N1) pandemic have stimulated renewed interest in the use of veno-venous extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) to support the respiratory system. Theoretical advantages of ECLS for respiratory failure include the ability to rest the lungs by avoiding injurious mechanical ventilator settings and the potential to...
Source: American Journal of Respiratory and Critical Care Medicine - July 21, 2014 Category: Respiratory Medicine Authors: Ventetuolo CE, Muratore CS Tags: Am J Respir Crit Care Med Source Type: research