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A Porcine Reproductive and Respiratory Syndrome Virus Vaccine Candidate Based on PRRSV Glycoprotein 5 and the Toll-Like Receptor 5 Agonist Salmonella typhimurium Flagellin
Glycoprotein 5 (GP5) from porcine reproductive and respiratory syndrome virus (PRRSV) is a key inducer of neutralizing antibodies. A truncated GP5 gene lacking the signal peptide and transmembrane sequences was amplified via an overlap PCR method and inserted into prokaryotic expression vectors, pET32a or pGEX-6p-1, to add an His or GST tag, respectively. His-tagged GP5 was induced with IPTG, verified by SDS-PAGE and Western blotting, and purified to serve as an immunogen accompanied with the Salmonella typhimurium flagellin (FliC), a Toll-like receptor 5 (TLR5) agonist. Levels of TLR5 and cytokine mRNAs in spleens of mice...
Source: Journal of Molecular Microbiology and Biotechnology - March 2, 2015 Category: Microbiology Source Type: research

Lung Deposition of Nebulized Surfactant in Newborn Piglets
Conclusions: Using this nebulizer, the lung depositions of porcine surfactant were 45% via endotracheal tube and 14% via nasal-continuous positive airway pressure (prongs). These figures might be physiologically relevant, but still have to be confirmed in efficacy studies.Neonatology 2015;107:277-282 (Source: Neonatology)
Source: Neonatology - March 2, 2015 Category: Perinatology & Neonatology Source Type: research

Prediction of Respiratory Outcome in Extremely Low Gestational Age Infants
Conclusions: RM documented by parental completed diaries at 12 months corrected age better predicted respiratory outcome at 24 months corrected age than BPD regardless of diagnostic criteria.Neonatology 2015;107:241-248 (Source: Neonatology)
Source: Neonatology - March 2, 2015 Category: Perinatology & Neonatology Source Type: research

Detection of functional hydrogen-bonded water molecules with protonated/deprotonated key carboxyl side chains in the respiratory enzyme ba3-oxidoreductase
Phys. Chem. Chem. Phys., 2015, Advance ArticleDOI: 10.1039/C5CP00043B, PaperAntonis Nicolaides, Tewfik Soulimane, Constantinos VarotsisIn this work we report FTIR data on the detection of functional hydrogen-bonded water molecules with protonated/deprotonated key carboxyl side chains in the respiratory enzyme ba3-oxidoreductase.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - March 2, 2015 Category: Chemistry Authors: Antonis Nicolaides Source Type: research

Preventive antibiotics in pediatric patients with acute myeloid leukemia (AML)
ConclusionsInitiation of preventive antibiotics at the onset of absolute neutropenia was associated with no mortality from bacteremia. This preventive approach appears feasible and safe. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - March 2, 2015 Category: Cancer & Oncology Authors: Dawn Nolt, Susan Lindemulder, Jeffrey Meyrowitz, Bill H. Chang, Suman Malempati, Gregory Thomas, Linda Stork Tags: Research Article Source Type: research

Severe measles pneumonia in adults with respiratory failure: role of ribavirin and high‐dose vitamin A
We present three adult cases (one of whom was pregnant) admitted to our University Hospital who were diagnosed to have measles and who had uncommon clinical features such as hepatitis and hyponatremia. All patients were markedly hypoxic; one required mechanical ventilation. Two patients received therapy with intravenous ribavirin and all patients received high‐dose vitamin A for 3 days. Therapy with intravenous ribavirin and vitamin A were well tolerated by our patients except one patient who developed acute renal failure and were associated with reversal of respiratory compromise. Life‐threatening measles pneumonitis ...
Source: The Clinical Respiratory Journal - March 2, 2015 Category: Respiratory Medicine Authors: Ebru Ortac Ersoy, Mine D. Tanriover, Serpil Ocal, Lale Ozisik, Cagkan Inkaya, Arzu Topeli Tags: Case Report Source Type: research

Deep breathing exercises with positive expiratory pressure in patients with multiple sclerosis – a randomized controlled trial
ConclusionBreathing exercises may be beneficial in patients with mild to moderate stages of MS. However, the clinical significance needs to be clarified, and it remains to be seen whether a sustainable effect in delaying the development of respiratory dysfunction in MS can be obtained. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 2, 2015 Category: Respiratory Medicine Authors: Elisabeth Westerdahl, Anna Wittrin, Margareta Kånåhols, Martin Gunnarsson, Ylva Nilsagård Tags: Original Article Source Type: research

Recurrent pneumonia due to olive aspiration in a healthy adult: a case report
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 2, 2015 Category: Respiratory Medicine Authors: Recep Akgedik, Ilknur Aytekin, Ali Bekir Kurt, Canan Eren Dağlı Tags: Letter to the Editor Source Type: research

Efficacy and safety of long‐term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis: a meta‐analysis
ConclusionFor patients with non‐CF bronchiectasis, long‐term inhaled antibiotics can effectively reduce the sputum bacterial density, increase P.A eradication and attenuate the risk of exacerbation, however, accompanied with higher risk of wheeze and bronchospasm. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 2, 2015 Category: Respiratory Medicine Authors: Jia‐Wei Yang, Li‐Chao Fan, Hai‐Wen Lu, Xia‐Yi Miao, Bei Mao, Jin‐Fu Xu Tags: Original Article Source Type: research

Initial empirical treatment based on clinical feature of chronic cough
ConclusionsThe empirical therapy aimed at primary diagnosis on the basis of history and clinical characteristics is a more targeted approach, and leads to improvement of chronic cough more quickly in most patients. CRC is the most common cause of chronic cough. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - March 2, 2015 Category: Respiratory Medicine Authors: Hai‐yan Deng, Wei Luo, Min Zhang, Jia‐xing Xie, Zhi‐ye Fang, Ke‐fang Lai Tags: Original Article Source Type: research

Mitochondrial membrane potential is regulated by vimentin intermediate filaments [Research Communication]
This study demonstrates that the association of mitochondria with vimentin intermediate filaments (VIFs) measurably increases their membrane potential. This increase is detected by quantitatively comparing the fluorescence intensity of mitochondria stained with the membrane potential-sensitive dye tetramethylrhodamine-ethyl ester (TMRE) in murine vimentin-null fibroblasts with that in the same cells expressing human vimentin (~35% rise). When vimentin expression is silenced by small hairpin RNA (shRNA) to reduce vimentin by 90%, the fluorescence intensity of mitochondria decreases by 20%. The increase in membrane potential...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Chernoivanenko, I. S., Matveeva, E. A., Gelfand, V. I., Goldman, R. D., Minin, A. A. Tags: Research Communication Source Type: research

Haemophilus influenzae increases the susceptibility and inflammatory response of airway epithelial cells to viral infections [Research Communication]
Nontypeable Haemophilus influenzae (NTHI), a common colonizer of lungs of patients with chronic obstructive pulmonary disease (COPD), can enhance expression of the cellular receptor intercellular adhesion molecule 1 (ICAM-1), which in turn can be used by major group human rhinoviruses (HRVs) for attachment. Here, we evaluated the effect of NTHI-induced up-regulation of ICAM-1 on viral replication and inflammatory responses toward different respiratory viruses. Therefore, human bronchial epithelial cells were pretreated with heat-inactivated NTHI (hi-NTHI) and subsequently infected with either HRV16 (major group), HRV1B (mi...
Source: FASEB Journal - March 2, 2015 Category: Biology Authors: Gulraiz, F., Bellinghausen, C., Bruggeman, C. A., Stassen, F. R. Tags: Research Communication Source Type: research

Strategies for safe living among lung transplant recipients: a single‐center survey
ConclusionsWe provide important insight into safe‐living practices following lung transplantation and identify specific areas and subgroups of patients that could be targeted for enhanced education, with potential significant clinical benefit. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - March 2, 2015 Category: Transplant Surgery Authors: A. Jain, A. Humar, D. Lien, J. Weinkauf, D. Kumar Tags: Original Report Source Type: research

The costs of inadequate breastfeeding of infants in Mexico [Nutritional epidemiology and public health]
Conclusions: This study provides costs of inadequate breastfeeding that had not been quantified in Mexico. The costs presented in this article provide the minimum amount that the country should invest to achieve better breastfeeding practices. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - March 2, 2015 Category: Nutrition Authors: Colchero, M. A., Contreras-Loya, D., Lopez-Gatell, H., Gonzalez de Cosio, T. Tags: Nutritional epidemiology and public health Source Type: research

n-3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention [Dietary supplements]
Conclusion: Iron supplementation increased morbidity (mostly respiratory) in iron-deficient South African schoolchildren with low DHA/EPA intake, but when iron was given in combination with DHA/EPA, this effect was prevented. This trial was registered at clinicaltrials.gov as NCT01092377. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - March 2, 2015 Category: Nutrition Authors: Malan, L., Baumgartner, J., Calder, P. C., Zimmermann, M. B., Smuts, C. M. Tags: Dietary supplements Source Type: research

Bifidobacterium animalis subsp. lactis fails to prevent common infections in hospitalized children: a randomized, double-blind, placebo-controlled study [Dietary supplements]
Conclusions: The results of this study show that the use of B. animalis subsp. lactis failed to prevent nosocomial infections in an acute-setting pediatric hospital in children who were >1 y of age. However, it should be taken into account that the overall incidence of nosocomial infections was lower than expected. This trial was registered at clinicaltrials.gov as NCT01702766. (Source: American Journal of Clinical Nutrition)
Source: American Journal of Clinical Nutrition - March 2, 2015 Category: Nutrition Authors: Hojsak, I., Tokić Pivac, V., Močić Pavić, A., Pasini, A. M., Kolaček, S. Tags: Dietary supplements Source Type: research

Beverage Habits and Mortality in Chinese Adults [Nutritional Epidemiology]
Conclusions: Higher coffee and black tea intake was inversely associated with mortality in never-smokers, light to moderate alcohol intake was inversely associated with mortality regardless of smoking status, heavy alcohol intake was positively associated with mortality in ever-smokers, and there was no association between sugar-sweetened beverages and green tea and mortality. (Source: Journal of Nutrition)
Source: Journal of Nutrition - March 2, 2015 Category: Nutrition Authors: Odegaard, A. O., Koh, W.-P., Yuan, J.-M., Pereira, M. A. Tags: Nutritional Epidemiology Source Type: research

Frequency of Acute Respiratory Illnesses in Households
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - March 2, 2015 Category: Pediatrics Authors: Brady, R. C. Tags: Infectious Diseases Source Type: research

Hair Nicotine Levels in Children With Bronchopulmonary Dysplasia
Little is known about the impact of tobacco smoke exposure on preterm children with bronchopulmonary dysplasia. It is essential to understand how environmental exposures, such as tobacco smoke, influence respiratory morbidities in this vulnerable population. Chronic tobacco smoke exposure is common in children with bronchopulmonary dysplasia. In children who required home respiratory support, hair nicotine levels were a better predictor of hospitalization and activity limitation than caregiver self-report. (Read the full article) (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Tags: Pediatrics Digest Summary Source Type: research

Noninvasive Ventilation Strategies for Early Treatment of RDS in Preterm Infants: An RCT
CONCLUSIONS: The present data show no statistically significant differences between NSIPPV and BiPAP strategies in terms of duration of ventilation and failures, suggesting that both NIV techniques are effective in the early treatment of RDS in VLBW infants. Further randomized investigations on wider populations are needed to evaluate the effect of NIV techniques on long-term outcomes. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Salvo, V., Lista, G., Lupo, E., Ricotti, A., Zimmermann, L. J. I., Gavilanes, A. W. D., Barberi, I., Colivicchi, M., Temporini, F., Gazzolo, D. Tags: Agency ABC''s Article Source Type: research

Vaccination, Underlying Comorbidities, and Risk of Invasive Pneumococcal Disease
CONCLUSIONS: In children with comorbidity, IPD results in higher mortality, and a large proportion of disease is due to serotypes not included in current conjugate vaccines. Further research is needed, specifically to develop and evaluate additional strategies for prevention of IPD in the most vulnerable children. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Yildirim, I., Shea, K. M., Little, B. A., Silverio, A. L., Pelton, S. I., on behalf of the Members of the Massachusetts Department of Public Health Tags: Article Source Type: research

Moisture Damage and Asthma: A Birth Cohort Study
CONCLUSIONS: Moisture damage and mold in early infancy in the child’s main living areas were associated with asthma development. Atopic children may be more susceptible to the effects of moisture damage and mold. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Karvonen, A. M., Hyvarinen, A., Korppi, M., Haverinen-Shaughnessy, U., Renz, H., Pfefferle, P. I., Remes, S., Genuneit, J., Pekkanen, J. Tags: Coding Corner Article Source Type: research

Sucrose and Warmth for Analgesia in Healthy Newborns: An RCT
CONCLUSIONS: The combination of sucrose and radiant warmth is an effective analgesic in newborns and reduces pain better than sucrose alone. The ready availability of this practical nonpharmacologic technique has the potential to reduce the burden of newborn pain. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Gray, L., Garza, E., Zageris, D., Heilman, K. J., Porges, S. W. Tags: Agency ABC''s Article Source Type: research

Hair Nicotine Levels in Children With Bronchopulmonary Dysplasia
CONCLUSIONS: Chronic TSE is common in children with BPD, with hair nicotine levels being more likely to detect TSE than caregiver self-report. Hair nicotine levels were also a better predictor of hospitalization and activity limitation in children with BPD who required respiratory support at outpatient presentation. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Collaco, J. M., Aherrera, A. D., Breysse, P. N., Winickoff, J. P., Klein, J. D., McGrath-Morrow, S. A. Tags: Health Briefs Article Source Type: research

Butyrfentanyl Overdose Resulting in Diffuse Alveolar Hemorrhage
We describe, to our knowledge, the first case of a butyrfentanyl overdose that resulted in clinically significant hemoptysis, acute lung injury, hypoxic respiratory failure, and diffuse alveolar hemorrhage. Complicating this case was a false-positive urine drug screen for fentanyl. Clinicians who encounter fentanyl exposures should be aware they may in fact be dealing with butyrfentanyl. As little is known of butyrfentanyl and our patient suffered a significant pulmonary hemorrhage, those who encounter butyrfentanyl exposures should monitor for hemorrhagic complications. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Cole, J. B., Dunbar, J. F., McIntire, S. A., Regelmann, W. E., Slusher, T. M. Tags: Case Report Source Type: research

A Case of Respiratory Depression in a Child With Ultrarapid CYP2D6 Metabolism After Tramadol
We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy. (Source: PEDIATRICS)
Source: PEDIATRICS - March 2, 2015 Category: Pediatrics Authors: Orliaguet, G., Hamza, J., Couloigner, V., Denoyelle, F., Loriot, M.-A., Broly, F., Garabedian, E. N. Tags: Case Report Source Type: research

Respiratory Care of Infants and Children with Congenital Tracheo-Oesophageal Fistula and Oesophageal Atresia.
This article will discuss the aetiology, classification, diagnosis and treatment of congenital TOF, with an emphasis on post-surgical respiratory management, recognition of early and late onset complications, and long-term clinical outcomes. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 2, 2015 Category: Respiratory Medicine Authors: Sara C. Sadreameli, Sharon A. McGrath-Morrow Source Type: research

Flow-volume loop abnormality detecting a previously unrecognized right upper lobe tracheal bronchus
We present a case of a patient who presented with a history of poorly controlled asthma and a persistent abnormality of the flow-volume loop. Bronchoscopy revealed a tracheal bronchus with narrowed right-sided bronchial orifices. An unrecognized tracheal bronchus may result in serious complications during elective or emergent endotracheal intubation. Spirometry testing may reveal abnormalities of the flow-volume loop associated with altered airflow. Relying on spirometric values without assessing the shape of the flow-volume loop may lead to misdiagnosis and inappropriate management of lung pathology. (Source: Respiratory ...
Source: Respiratory Medicine Case Reports - March 2, 2015 Category: Respiratory Medicine Source Type: research

Timolol-Induced Interstitial Lung Disease
Publication date: Available online 2 March 2015 Source:Respiratory Medicine Case Reports Author(s): Hetain Patel , Lina Vanessa Wilches , Jorge Guerrero Timolol maleate is a non-selective beta -adrenergic receptor blocking agent with demonstrated efficacy in the treatment of open angle glaucoma. A 76 year old female who presented with productive cough, progressive dyspnea and hypoxia after starting timolol maleate opthalamic drops following glaucoma surgery. The patient was diagnosed with interstitial lung disease secondary to timolol treatment and after cessation of the offending agent along with corticosteroid treatmen...
Source: Respiratory Medicine Case Reports - March 2, 2015 Category: Respiratory Medicine Source Type: research

Surfactant Protein B Deficiency Caused by Homozygous C248X Mutation—A Case Report and Review of the Literature
Conclusion Thirty-four mutations have been published in the literature. Treatment options are scarce. Gene therapy is hoped to be an option in the future.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  open access Full text (Source: American Journal of Perinatology Reports)
Source: American Journal of Perinatology Reports - March 2, 2015 Category: Perinatology & Neonatology Authors: Kurath-Koller, StefanResch, BernhardKraschl, RaimundWindpassinger, ChristianEber, Ernst Tags: Case Report Source Type: research

The Timing of Discharge from ICU and Subsequent Mortality: A Prospective Multi-center Study.
Conclusion In this large prospective multi-center bi-national observational study, we found that patient status at ICU discharge, particularly the presence of LOMT orders, was the chief predictor of hospital survival. In contrast to previous studies, the timing of discharge did not have an independent association with mortality. PMID: 25730675 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 2, 2015 Category: Respiratory Medicine Authors: Santamaria JD, Duke GJ, Pilcher DV, Cooper DJ, Moran J, Bellomo R, for the Discharge and Readmission Evaluation (DARE) study Tags: Am J Respir Crit Care Med Source Type: research

The DosR Regulon Modulates Adaptive Immunity and is Essential for M. tuberculosis Persistence.
Conclusions: Delayed adaptive responses, a hallmark of Mtb infection, not only lead to persistence but also interfere with the development of effective anti-TB vaccines. The DosR regulon therefore modulates both the magnitude and the timing of adaptive immune responses in response to hypoxia in-vivo, resulting in persistent infection. Hence, DosR regulates key aspects of the Mtb life cycle and in limiting lung pathology. PMID: 25730547 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 2, 2015 Category: Respiratory Medicine Authors: Mehra S, Foreman TW, Didier PJ, Ahsan MH, Hudock TA, Kissee R, Golden NA, Gautam US, Johnson AM, Alvarez X, Russell-Lodrigue KE, Doyle LA, Roy CJ, Blanchard JL, Khader SA, Lackner AA, Sherman DR, Kaushal D Tags: Am J Respir Crit Care Med Source Type: research

Impaired Antibody-mediated Protection and Defective IgA B Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus.
Conclusions: This observed specific defect in IgA memory may partly explain RSV's ability to cause recurrent symptomatic infections. If so, vaccines able to induce durable RSV-specific IgA responses may be more protective than those generating systemic antibody alone. PMID: 25730467 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - March 2, 2015 Category: Respiratory Medicine Authors: Habibi MS, Jozwik A, Makris S, Dunning J, Paras A, DeVincenzo JP, de Haan CA, Wrammert J, Openshaw PJ, Chiu C, The MOSAIC Investigators Tags: Am J Respir Crit Care Med Source Type: research

Plastic bronchitis associated with influenza
Dear Editor, the recent report on “Plastic bronchitis (PB) associated with influenza” is very interesting [1]. Zhang and Kang noted that “PB is a life-threatening complication of severe influenza” and “diagnosis should be made by bronchial endoscopy and histopathology, and bronchial casts removed as early as possible [1].” Similar finding is recently reported from China by Zheng et al. Zheng et al. showed that PB should be considered in any children with “rapid and progressive respiratory distress with lung atelectasis or consolidation on chest radiograph [2].” The main pathogenesis is believed to due to ...
Source: International Journal of Pediatric Otorhinolaryngology - March 2, 2015 Category: ENT & OMF Authors: Beuy Joob, Viroj Wiwanitkit Tags: Letter to the Editor Source Type: research

Symptom Management in the Older Adult
This article updates the 2002 Jamie von Roenn article about “the palliation of commonly observed symptoms in older patients, including pain, neuropsychiatric, gastrointestinal, and respiratory symptoms.” When palliative care was last covered in Geriatric Clinics, President George W. Bush had just signed the No Child Left Behind Act, Homeland Security was being established, Michael Jackson won the Artist of the Century Award at the American Music Awards, and gas cost $1.61 a gallon. What has changed in the last decade and a half? (Source: Clinics in Geriatric Medicine)
Source: Clinics in Geriatric Medicine - March 2, 2015 Category: Geriatrics Authors: Thomas J. Smith Source Type: research

Diarrhea at the Hajj and Umrah
This systematic review aims to summarize the incidence and etiology of diarrheal illness among pilgrims attending the Hajj and Umrah. Gastroenteritis and diarrhea have been potential threats during previous Hajj pilgrimages. The last cases of Hajj related cholera were reported in 1989. Currently, respiratory tract infections account for the majority of health problems during the Hajj. This shift in epidemiology reflects the improvement of sanitary conditions in Saudi Arabia in general, and at religious sites in particular. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - March 2, 2015 Category: Infectious Diseases Authors: Philippe Gautret, Samir Benkouiten, Shruti Sridhar, Jaffar A. Al-Tawfiq, Ziad A. Memish Source Type: research

Health professionals’ opinion about services for tuberculosis control
Conclusion: According to professionals, the performance of health services in tuberculosis control with relation to focus on family is satisfactory, but guidance actions for the community are unsatisfactory. (Source: Acta Paulista de Enfermagem)
Source: Acta Paulista de Enfermagem - March 1, 2015 Category: Nursing Source Type: research

Muscle IGF-1-Induced Skeletal Muscle Hypertrophy Evokes Higher Insulin Sensitivity and Carbohydrate Use as Preferential Energy Substrate.
Abstract We characterized the metabolic profile of transgenic mice exhibiting enhanced muscle mass driven by increased mIGF-1 expression (MLC/mIGF-1). As expected, 6-month-old MLC/mIGF-1 mice were heavier than age-matched wild type (WT) mice (37.4 ± 0.3 versus 31.8 ± 0.6 g, resp.). MLC/mIGF-1 mice had higher respiratory quotient when compared to WT (0.9 ± 0.03 versus 0.74 ± 0.02, resp.) suggesting a preference for carbohydrate as the major fuel source. MLC/mIGF-1 mice had a higher rate of glucose disposal when compared to WT (3.25 ± 0.14 versus 2.39 ± 0.03%/min, resp.). The higher disposal rate correlated t...
Source: Biomed Res - March 1, 2015 Category: Research Authors: Christoffolete MA, Silva WJ, Ramos GV, Bento MR, Costa MO, Ribeiro MO, Okamoto MM, Lohmann TH, Machado UF, Musarò A, Moriscot AS Tags: Biomed Res Int Source Type: research

Early Initiation of Continuous Renal Replacement Therapy Improves Clinical Outcomes in Patients With Acute Respiratory Distress Syndrome
Conclusions: Our findings showed that early initiation of CRRT is associated with favorable clinical outcomes in ARDS patients, which might be due to the reduced serum and BALF TGF-β1 levels through CRRT. However, large multi-center studies are needed to make further recommendations as to the optimal use of CRRT in ARDS patient populations. (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - March 1, 2015 Category: Journals (General) Tags: Clinical Investigation Source Type: research