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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

Complications associated with laparoscopic adrenalectomy: Description and standardized assessment
Conclusions Standardized criteria of surgical complications are necessary. Standardization is possible by combined application of two tools. We believe that this evaluation concept of the surgery morbidity must be used systematically in order to achieve a new standard refined, concise and comparative for reports of adverse perioperative events. (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - October 22, 2014 Category: Urology & Nephrology Source Type: research

Lung involvement in children with lysinuric protein intolerance
Conclusion PAP is a constant feature in children with LPI and lung involvement. Pulmonary fibrosis is frequent and these two pathologies may develop independently. This study shows the heterogeneity of presentation and outcome. Lung injury could be secondary to impaired phagocytic function and abnormal inflammatory and immune responses intrinsic to the SLC7A7 mutant phenotype. HRCT is recommended to detect lung involvement. (Source: Journal of Inherited Metabolic Disease)
Source: Journal of Inherited Metabolic Disease - October 22, 2014 Category: Internal Medicine Source Type: research

Combined BNP and Echocardiographic assessment in interstitial lung disease for pulmonary hypertension detection
Natriuretic Peptides (B-type natriuretic peptide [BNP] and NT pro-BNP) are proposed biomarkers to differentiate between cardiac and pulmonary causes of acute dyspnea [1]. Some emerging data proposed the use in respiratory disease and particularly in patients with acute pulmonary embolism and pulmonary hypertension (PH) [2]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - October 22, 2014 Category: Cardiology Authors: Alberto Palazzuoli, Gaetano Ruocco, Behar Cekorja, Marco Pellegrini, Gabriele Del Castillo, Ranuccio Nuti Tags: Letter to the editor Source Type: research

Sputum club cell protein concentration is associated with pulmonary exacerbation in cystic fibrosis
Cystic fibrosis (CF) patients exhibit a progressive decline in lung function accelerated by intermittent pulmonary exacerbations. There are urgent needs for clinically relevant biomarkers to aid in the diagnosis and management of a CF pulmonary exacerbation, in addition to providing insight into its pathophysiology. Club cell secretory protein (CCSP) is produced by bronchial epithelial cells, known to have anti-inflammatory properties and may play a role in CF pulmonary exacerbations. Our objective was to measure sputum CCSP concentration during hospitalizations for CF pulmonary exacerbation and during quarterly outpatient...
Source: Journal of Cystic Fibrosis - October 22, 2014 Category: Respiratory Medicine Authors: Theresa A. Laguna, Cynthia B. Williams, Kyle R. Brandy, Cole Welchlin-Bradford, Catherine E. Moen, Cavan S. Reilly, Christine H. Wendt Source Type: research

The effect of short-term, high-dose oral N-acetylcysteine treatment on oxidative stress markers in cystic fibrosis patients with chronic infection — A pilot study
Patients with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infection have increased oxidative stress as a result of an imbalance between the production of reactive oxygen species caused by inflammation and their inactivation by the impaired antioxidant systems. Supplementation with anti-oxidants is potentially beneficial for CF patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 22, 2014 Category: Respiratory Medicine Authors: Marianne Skov, Tacjana Pressler, Jens Lykkesfeldt, Henrik Enghusen Poulsen, Peter Østrup Jensen, Helle Krogh Johansen, Tavs Qvist, Dorthe Kræmer, Niels Høiby, Oana Ciofu Tags: Original Article Source Type: research

Improving mitochondrial bioenergetics under ischemic conditions increases warm ischemia tolerance in the kidney.
IMPROVING MITOCHONDRIAL BIOENERGETICS UNDER ISCHEMIC CONDITIONS INCREASES WARM ISCHEMIA TOLERANCE IN THE KIDNEY. Am J Physiol Renal Physiol. 2014 Oct 22; Authors: Szeto HH, Liu S, Soong Y, Birk AV Abstract Ischemia time during partial nephrectomy is strongly associated with acute and chronic renal injury. ATP depletion during warm ischemia inhibits ATP-dependent processes, resulting in cell swelling, cytoskeletal breakdown and cell death. The duration of ischemia tolerated by the kidney depends on the amount of ATP that can be produced with residual substrates and oxygen in the tissue to sustain cell f...
Source: American Journal of Physiology. Renal Physiology - October 22, 2014 Category: Physiology Authors: Szeto HH, Liu S, Soong Y, Birk AV Tags: Am J Physiol Renal Physiol Source Type: research

Calcium Restores the Macrophage Response to Non-typeable Haemophilus influenzae in COPD.
Conclusions: Extracellular calcium improved phagocytosis, restored innate cytokine secretion and increased cell surface expression of bacterial recognition receptors, CD16 and MARCO. These observations support the therapeutic use of calcium to improve macrophage function in COPD to decrease exacerbations and chronic bacterial infection. PMID: 25338285 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - October 22, 2014 Category: Molecular Biology Authors: Provost KA, Smith M, Arold SP, Hava DL, Sethi S Tags: Am J Respir Cell Mol Biol Source Type: research

Rho-kinase Mediates Right Ventricular Systolic Dysfunction in Rats with Chronic Neonatal Pulmonary Hypertension.
Conclusions: Pressure unloading and regressed arterial and cardiac remodeling did not lead to recovery of systolic function while right ventricular Rho-kinase activity remained increased. Right ventricle-specific up-regulation of RhoA/Rho-kinase activity is critical to hypoxia-mediated systolic dysfunction, in part by regulating the activity of phosphodiesterase 5. PMID: 25337652 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - October 22, 2014 Category: Molecular Biology Authors: Gosal K, Dunlop K, Dhaliwal R, Ivanovska J, Kantores C, Desjardins JF, Connelly KA, McNamara PJ, Jain A, Jankov RP Tags: Am J Respir Cell Mol Biol Source Type: research

Health-care associate transmission of Middle East Respiratory Syndrome Corona virus, MERS-CoV, in the Kingdom of Saudi Arabia
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 22, 2014 Category: Infectious Diseases Authors: Eskild Petersen, Marjorie M. Pollack, Lawrence C. Madoff Source Type: research

The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia
Pneumonia is a generic term used to described acute inflammation of the lower respiratory tract and is a primary cause of hospitalization and death in children under 5 years of age [1–9] worldwide, and viruses and bacteria are the most common etiological agents [5–7]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - October 22, 2014 Category: Virology Authors: Emanuele Baurakiades, Victor Horácio Costa, Sonia Maria Raboni, Vivian Rafaela Telli de Almeida, Kelly Susana Kunze Larsen, Juliana Nemetz Kohler, Priscilla do Carmo Gozzo, Giseli Klassen, Graciele C.M. Manica, Lucia de Noronha Source Type: research

Ethical Dilemmas of Adult ECMO: Emerging Conceptual Challenges
EXTRACORPOREAL MEMBRANE OXYGENATION (ECMO) is an invaluable rescue therapy for patients with refractory respiratory or cardiac failure. Recent developments in cardiopulmonary bypass technology, such as miniaturized extracorporeal devices, heparin-coated circuits, and percutaneous cannulation techniques, have facilitated widespread application of ECMO in different clinical situations.1 The decision to initiate ECMO is made more difficult by uncertainties surrounding who might most benefit from it. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 22, 2014 Category: Anesthesiology Authors: Kollengode Ramanathan, Matthew E. Cove, Michael G. Caleb, Kristine L.K. Teoh, Graeme Maclaren Tags: Special Article Source Type: research

Supraglottic epithelial hyperplasia in association with guttate psoriasis
Supraglottic epithelial hyperplasia is rare in the pediatric population, and typically presents in adults as a sequelae of radiation therapy or progressive autoimmune disease. Guttate psoriasis typically presents in young adults following an inflammatory trigger such as an upper respiratory infection or streptococcal pharyngitis. A case of stridorous episodes heralded by flares guttate psoriasis is presented. Pathologic analysis demonstrated supraglottic epithelial hyperplasia. This case demonstrates a rare cause of stridor and upper airway obstruction in children. (Source: International Journal of Pediatric Otorhinolaryngology Extra)
Source: International Journal of Pediatric Otorhinolaryngology Extra - October 22, 2014 Category: ENT & OMF Authors: Jon Mallen-St. Clair, Fernando Palma-Diaz, Nina L. Shapiro Tags: CaseReport Source Type: research

AMPAkines Have Novel Analgesic Properties in Rat Models of Persistent Neuropathic and Inflammatory Pain
Conclusions: AMPAkines alleviate pain hypersensitivity as well as depression-like behavior associated with long-lasting nerve injury and inflammatory insult. (Source: Anesthesiology)
Source: Anesthesiology - October 21, 2014 Category: Anesthesiology Tags: Pain Medicine: Basic Science Source Type: research

Pupillary Effects of High-dose Opioid Quantified with Infrared Pupillometry
Conclusions: Opioid administration with significant accompanying hypercarbia and hypoxia results in pupil diameters of 2 to 3 mm and a reduced but quantifiable pupillary light reflex. The authors conclude that the pupillary examination and evaluation of the light reflex remain useful for neurologic assessment during opioid toxicity. (Source: Anesthesiology)
Source: Anesthesiology - October 21, 2014 Category: Anesthesiology Tags: Critical Care Medicine: Clinical Science Source Type: research

Effects of Neostigmine Reversal of Nondepolarizing Neuromuscular Blocking Agents on Postoperative Respiratory Outcomes: A Prospective Study
Conclusions: Neostigmine reversal did not affect oxygenation but was associated with increased atelectasis. High-dose neostigmine or unwarranted use of neostigmine may translate to increased postoperative respiratory morbidity. (Source: Anesthesiology)
Source: Anesthesiology - October 21, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Clinical Science Source Type: research

Effectiveness of a Dental Care Intervention in the Prevention of Lower Respiratory Tract Nosocomial Infections among Intensive Care Patients: A Randomized Clinical Trial
Wanessa T. Bellissimo-Rodrigues, DDS, PhD; Mayra G. Menegueti, RN, MS; Gilberto G. Gaspar, MD, PhD; Edson A. Nicolini, MD; Maria Auxiliadora-Martins, MD, PhD; Anibal Basile-Filho, MD, PhD; Roberto Martinez, MD, PhD; Fernando Bellissimo-Rodrigues, MD, PhD Infection Control and Hospital Epidemiology, Volume 35, Issue 11, Page 1342-1348, November 2014. (Source: Infect Control Hosp Epidemiol Latest Issue)
Source: Infect Control Hosp Epidemiol Latest Issue - October 21, 2014 Category: Epidemiology Tags: article Original Articles Source Type: research

Characterisation of novel linear antigen epitopes on North American-type porcine reproductive and respiratory syndrome virus M protein
In this study, two different Mab clones targeting the linear epitopes on the PRRSV M protein were generated and characterized. Both Mabs showed binding activity against the native PRRSV virion and recombinant M protein when analyzed by immunofluorescence assay (IFA) and Western blot. The targeted epitope of each Mab was mapped by serial truncation of the M protein to generate overlapping fragments. Fine epitope mapping was then performed using a panel of expressed polypeptides. The polypeptide sequences of the two epitopes recognized by Mabs 1C8 and 3F7 were 3SSLD6 and 155VLGGRKAVK163, respectively, with the former bei...
Source: Archives of Virology - October 21, 2014 Category: Virology Source Type: research

Improving outcomes for people with COPD by developing networks of general practices: evaluation of a quality improvement project in east London.
CONCLUSIONS: Investment of financial, organisational and educational resource into general practice networks was associated with clinically important improvements in COPD care in socially deprived, ethnically diverse communities. Key behaviour change included the following: collaborative working between practices driven by high-quality information to support performance review; shared financial incentives; and engagement between primary and secondary care clinicians. PMID: 25322204 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - October 21, 2014 Category: Primary Care Authors: Hull S, Mathur R, Lloyd-Owen S, Round T, Robson J Tags: NPJ Prim Care Respir Med Source Type: research

Prevalence of inappropriate prescribing of inhaled corticosteroids for respiratory tract infections in the Netherlands: a retrospective cohort study.
CONCLUSION: In the Netherlands one-off ICS dispensing in combination with oral antibiotics in subjects without chronic respiratory conditions was considerably lower than in Australia. PMID: 25320938 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - October 21, 2014 Category: Primary Care Authors: Teichert M, Schermer T, van den Nieuwenhof L, De Smet PA, Wensing M Tags: NPJ Prim Care Respir Med Source Type: research

[Series] Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options
The emergence and spread of antimicrobial-resistant bacterial, viral, and fungal pathogens for which diminishing treatment options are available is of major global concern. New viral respiratory tract infections with epidemic potential, such as severe acute respiratory syndrome, swine-origin influenza A H1N1, and Middle East respiratory syndrome coronavirus infection, require development of new antiviral agents. The substantial rise in the global numbers of patients with respiratory tract infections caused by pan-antibiotic-resistant Gram-positive and Gram-negative bacteria, multidrug-resistant Mycobacterium tuberculosis, ...
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Alimuddin Zumla, Ziad A Memish, Markus Maeurer, Matthew Bates, Peter Mwaba, Jaffar A Al-Tawfiq, David W Denning, Frederick G Hayden, David S Hui Tags: Series Source Type: research

[Series] Emerging viral respiratory tract infections—environmental risk factors and transmission
The past decade has seen the emergence of several novel viruses that cause respiratory tract infections in human beings, including Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia, an H7N9 influenza A virus in eastern China, a swine-like influenza H3N2 variant virus in the USA, and a human adenovirus 14p1 also in the USA. MERS-CoV and H7N9 viruses are still a major worldwide public health concern. The pathogenesis and mode of transmission of MERS-CoV and H7N9 influenza A virus are poorly understood, making it more difficult to implement intervention and preventive measures. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Philippe Gautret, Gregory C Gray, Remi N Charrel, Nnanyelugo G Odezulu, Jaffar A Al-Tawfiq, Alimuddin Zumla, Ziad A Memish Tags: Series Source Type: research

[Series] Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections—needs, advances, and future prospects
Respiratory tract infections rank second as causes of adult and paediatric morbidity and mortality worldwide. Respiratory tract infections are caused by many different bacteria (including mycobacteria) and viruses, and rapid detection of pathogens in individual cases is crucial in achieving the best clinical management, public health surveillance, and control outcomes. Further challenges in improving management outcomes for respiratory tract infections exist: rapid identification of drug resistant pathogens; more widespread surveillance of infections, locally and internationally; and global responses to infections with pan...
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Alimuddin Zumla, Jaffar A Al-Tawfiq, Virve I Enne, Mike Kidd, Christian Drosten, Judy Breuer, Marcel A Muller, David Hui, Markus Maeurer, Matthew Bates, Peter Mwaba, Rafaat Al-Hakeem, Gregory Gray, Philippe Gautret, Abdullah A Al-Rabeeah, Ziad A Memish, V Tags: Series Source Type: research

[Articles] Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study
In patients with severe MERS-CoV infection, ribavirin and interferon alfa-2a therapy is associated with significantly improved survival at 14 days, but not at 28 days. Further assessment in appropriately designed randomised trials is recommended. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Ali S Omrani, Mustafa M Saad, Kamran Baig, Abdelkarim Bahloul, Mohammed Abdul-Matin, Amal Y Alaidaroos, Ghaleb A Almakhlafi, Mohammed M Albarrak, Ziad A Memish, Ali M Albarrak Tags: Articles Source Type: research

[Comment] Investment in pneumonia and pneumococcal research
The worldwide burden of pneumonia is high—the disease caused 1·2 million deaths in 2010, mostly in children younger than 2 years. In the same year, at least 76·7 million disability-adjusted life-years (DALYs) were attributed to pneumonia and pneumococcal disease, although DALYs are inevitably increased in diseases that mostly affect young children. Infections of the lower respiratory tract (many of which are probably pneumonia-related) were the single largest cause of worldwide DALYs in children younger than 1 year. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Michael G Head, Joseph R Fitchett, Marie-Louise Newell, J Anthony G Scott, Stuart C Clarke, Rifat Atun Tags: Comment Source Type: research

[Comment] Treating MERS-CoV during an outbreak
When a new virus emerges, health-care systems face major challenges, not least of which is deciding which treatments to use. The drug development process, from novel compound screening to final approval, can take more than 10 years to complete and cost hundreds of millions of dollars. By contrast, viruses can emerge rapidly, spread widely, and pose a substantial, immediate threat to public health. For example, Middle East respiratory syndrome coronavirus (MERS-CoV) was first reported in November, 2012, and, as of September, 2014, cases have been reported in 21 countries, with 837 confirmed cases and 319 deaths. (Source: Th...
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: Christopher M Coleman, Matthew B Frieman Tags: Comment Source Type: research

[Editorial] Enterovirus D68: the unexpected guest
Reports of increasing numbers of children admitted to hospital with severe respiratory illness and associated muscle weakness and paralysis in the USA and Canada have caused alarm. Enterovirus D68—a member of the enterovirus genus that also includes rhinoviruses, coxsackieviruses, and polioviruses—is believed to be the most likely cause of this outbreak. Infections caused by this virus are rarely reported (only 79 cases were recorded between 2009 and 2013 in the USA) and they normally involve mild respiratory symptoms similar to a cold, but these can become severe in children with underlying problems such as asthma. (S...
Source: The Lancet Infectious Diseases - October 21, 2014 Category: Infectious Diseases Authors: The Lancet Infectious Diseases Tags: Editorial Source Type: research

Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury
Conclusions: Our findings suggest that the WNT/?-catenin signaling pathway is activated very early in sepsis-induced ARDS and could play an important role in lung repair and fibrosis. Modulation of this pathway might represent a potential target for treatment for septic and ARDS patients. (Source: Critical Care)
Source: Critical Care - October 21, 2014 Category: Intensive Care Authors: Jesús VillarNuria Cabrera-BenítezÁngela Ramos-NuezCarlos FloresSonia García-HernándezFrancisco ValladaresJosefina López-AguilarLluís BlanchArthur Slutsky Source Type: research

Electrogram-Gated Radiofrequency Ablations With Duty Cycle Power Delivery Negate Effects of Ablation Catheter Motion [Original Articles]
Conclusions— (1) Lesion depth decreases and length increases in conventional ablations with greater degrees of lateral catheter movements; (2) electrogram-gated pulsed radiofrequency delivery negated the effects from lateral catheter movement by creating consistently deeper lesions irrespective of the degree of catheter movement; and (3) target lesion depths were reached significantly faster in electrogram-gated than in conventional ablations. (Source: Circulation: Arrhythmia and Electrophysiology)
Source: Circulation: Arrhythmia and Electrophysiology - October 21, 2014 Category: Cardiology Authors: Chik, W. W. B., Barry, M. A., Pouliopoulos, J., Byth, K., Midekin, C., Bhaskaran, A., Sivagangabalan, G., Thomas, S. P., Ross, D. L., McEwan, A., Kovoor, P., Thiagalingam, A. Tags: Ablation/ICD/surgery Original Articles Source Type: research

Analysis of traditional knowledge of medicinal plants from residents in Gayasan National Park (Korea)
Conclusion: The results of the inter-network analysis will provide a suitable plan for sustainable preservation of the national park through a continued study of the data. Particular species of medicinal plants need to be protected for a balanced plant ecosystem within the park. Consequently, through further studies using these results, proper steps need to be established for preparing a wise alternative to create a sustainable natural plant ecosystem for Gayasan National Park and other national parks. (Source: Journal of Ethnobiology and Ethnomedicine)
Source: Journal of Ethnobiology and Ethnomedicine - October 21, 2014 Category: Complementary Medicine Authors: Mi-Jang SongHyun KimByoung-Yoon LeeHeldenbrand BrianChan-Ho ParkChang-Woo Hyun Source Type: research

Using Medicaid and CHIP Claims Data to Support Pediatric Quality Measurement: Lessons From 3 Centers of Excellence in Measure Development
Conclusions Our experience constructing quality measure specifications using claims data suggests that it will be challenging to measure key quality of care constructs for Medicaid-insured children at a national level in a timely and consistent way. Without better data to underpin pediatric quality measurement, Medicaid and CHIP will have difficulty using some existing measures for accountability, value-based purchasing, and quality improvement both across states and within states. (Source: Academic Pediatrics)
Source: Academic Pediatrics - October 21, 2014 Category: Pediatrics Source Type: research

Soft palatal webbing flap palatopharyngoplasty for both soft palatal and oropharyngeal lateral wall collapse in the treatment of snoring and obstructive sleep apnea: a new innovative technique without tonsillectomy
Conclusion Soft palatal webbing flap palatopharyngoplasty provided objective clinical improvement of OSA in adults with soft palatal and lateral pharyngeal wall collapse and has the potential to serve as an effective alternative for these cases. (Source: Sleep and Breathing)
Source: Sleep and Breathing - October 21, 2014 Category: Respiratory Medicine Source Type: research

Effect of Laparotomy on the Swallow–Breathing Relationship in the Cat
Abstract Swallow occurs predominantly in the expiratory phase (E) of breathing. This phase preference is thought to contribute to airway protection by limiting the passage of material through the pharyngeal airway with little or no inspiratory (I) airflow. This phase preference is attributed to central interactions between the swallow and breathing pattern generators. We speculated that changes in peripheral mechanical factors would influence the respiratory phase preference for swallow initiation. We induced swallowing in anesthetized spontaneously breathing cats by injection of water into the oropharynx. In anim...
Source: Lung - October 21, 2014 Category: Respiratory Medicine Source Type: research

Protective Association of TIM1−1454G>A Polymorphism with Asthma in a North Indian Population
Conclusions This is the first study conducted in India conferring −1454G>A polymorphism provides resistance toward asthma while lack of association was found between −416G>C polymorphism and asthma in the studied North Indian population. (Source: Lung)
Source: Lung - October 21, 2014 Category: Respiratory Medicine Source Type: research

Evaluation of High-Sensitivity Serum CRP Levels Compared to Markers of Airway Inflammation and Allergy as Predictors of Methacholine Bronchial Hyper-Responsiveness in Children
Conclusions hs-CRP levels were not helpful, while FeNO, IgE, and eosinophils were useful in the prediction of methacholine bronchial hyper-responsiveness in our group of children. (Source: Lung)
Source: Lung - October 21, 2014 Category: Respiratory Medicine Source Type: research

The Impact of Screening Tools on Diagnosis of Chronic Obstructive Pulmonary Disease in Primary Care
Conclusions Office-based assessment can significantly increase COPD diagnosis by primary care physicians. Future trials must evaluate whether screening can improve outcomes for patients with COPD. (Source: American Journal of Preventive Medicine)
Source: American Journal of Preventive Medicine - October 21, 2014 Category: Global & Universal Source Type: research

Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions
Abstract Epidemiologic studies have linked diesel exhaust (DE) to cardiovascular and respiratory morbidity and mortality, as well as lung cancer. DE composition is known to vary with many factors, although it is unclear how this influences toxicity. We generated eight DE atmospheres by applying a 2 × 2 × 2 factorial design and altering three parameters in a controlled exposure facility: (1) engine load (27 vs 82 %), (2) particle aging (residence time ~5 s vs ~5 min prior to particle collection), and (3) oxidation (with or without ozonation during dilution). Selected exposure concentrations of both die...
Source: Air Quality, Atmosphere and Health - October 21, 2014 Category: Environmental Health Source Type: research

Unique properties of cbb3 H+ channel [Biophysics and Computational Biology]
The respiratory chains of nearly all aerobic organisms are terminated by proton-pumping heme-copper oxygen reductases (HCOs). Previous studies have established that C-family HCOs contain a single channel for uptake from the bacterial cytoplasm of all chemical and pumped protons, and that the entrance of the KC-channel is a conserved glutamate... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 21, 2014 Category: Science Authors: Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S.–R., Arȷona, D., Rousseau, D. L., Taȷkhorshid, E., Adelroth, P., Gennis, R. B. Tags: PNAS Plus Source Type: research

MERS-CoV entry mediated by furin [Microbiology]
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) protein is the main determinant of viral entry, and although it was previously shown that MERS-CoV S can be activated by various proteases, the details of the mechanisms... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 21, 2014 Category: Science Authors: Millet, J. K., Whittaker, G. R. Tags: Biological Sciences Source Type: research

Shear stress upregulates IL‐1β secretion by Chlamydia pneumoniae‐ infected monocytes
Abstract Infectious agents are increasingly implicated in the development and progression of chronic inflammatory diseases. Several lines of evidence suggest that the common intracellular respiratory pathogen, Chlamydia pneumoniae contributes to the well‐established risk factors of atherosclerosis but the exact mechanism is not well understood. It is believed that C. pneumoniae‐infected monocytes travel from the lung to the atherosclerotic foci, during which the cells experience mechanical stimuli due to blood flow. In this work, we characterized the effect of physiological levels of shear stress on C. pneumoniae‐inf...
Source: Biotechnology and Bioengineering - October 21, 2014 Category: Biomedical Science Authors: Aswathi Cheeniyil, Shankar J. Evani, Shatha F. Dallo, Anand K. Ramasubramanian Tags: Tissue Engineering and Delivery Systems Source Type: research

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study
COPD symptoms are more common in the early morning and day versus the night and over half of the 727 patients studied experienced symptoms during a 24 hour period. These outcomes should be considered when managing the disease. (Source: Respiratory Research)
Source: Respiratory Research - October 21, 2014 Category: Respiratory Medicine Authors: Marc MiravitllesHeinrich WorthJuan Soler CataluñaDavid PriceFernando de BenedettoNicolas RocheNina GodtfredsenThys van der MolenClaes-Göran LöfdahlLaura PadullésAnna Ribera Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes ‐Dermatomyositis and Lambert‐Eaton myasthenic syndrome
We reported a case of a 60‐year‐old male smoker who presented multiple erythematous lesion for six months with progressive proximal muscular weakness, and developed to dysphonia in two months. His chest computed tomography showed a spiculate pulmonary nodule near the hilar in the right upper lobe and mediastinal lymph nodes enlargement. Lung biopsy showed squamous cell carcinoma. The patients’blood test revealed elevated creatine kinase levels. Electromyography results was consistent with moderate myopathy accompanied with a pattern suggestive of Lambert‐Eaton myasthenic syndrome. So we made the diagnosis of an ove...
Source: The Clinical Respiratory Journal - October 21, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: Other Source Type: research

Tuberculous pleuritis secondary to Mycobacterium bovis in a veterinarian
Abstract Mycobacterium bovis is a rare cause of tuberculosis in humans, but should be considered in individuals at risk secondary to medical co‐morbidities (notably immunocompromise) or occupational exposure. Most cases are secondary to re‐activation of latent infection in elderly individuals although cases of primary infection still occur, usually involving animal‐to‐human transmission. Pleural fluid culture in the context of suspected tuberculous pleuritis is frequently negative and pleural biopsy significantly increases the likelihood of confirming the diagnosis histologically and microbiologically. Although tho...
Source: The Clinical Respiratory Journal - October 21, 2014 Category: Respiratory Medicine Authors: John P Corcoran, Robert J Hallifax, Henry V Bettinson, Ioannis Psallidas, Najib M Rahman Tags: Original Article Source Type: research

Prenatal administration of all- trans retinoic acid upregulates leptin signaling in hypoplastic rat lungs with experimental congenital diaphragmatic hernia
Conclusion Increased Lep and Lep-R expression after prenatal administration of ATRA in nitrofen-induced PH suggests that ATRA may have therapeutic potential in attenuating CDH-associated PH by stimulating alveolarization and de novo surfactant production. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - October 21, 2014 Category: Surgery Source Type: research

Parablastomonas arctica gen. nov., sp. nov., a bacterium isolated from high Arctic glacial till.
Abstract A pale yellow pigmented, aerobic bacterium, strain M0-2T, was isolated from a till sample. Its taxonomic position was investigated by using a polyphase approach. Cells are Gram-stain-negative, rod-shaped and motile. Cells reproduce by budding or asymmetric cell division. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain M0-2T belonged to the family Sphingomonadaceae and was closely related to Novosphingobium species (96.4-92.0%), Blastomonas species (94.6%), Sphingopyxis witflariensis W-50T (94.0%), Sphingosinicella soli KSL-125T (93.6%) and Sphingomonas astaxanthinifaciens TDMA-...
Source: International Journal of Systematic and Evolutionary Microbiology - October 21, 2014 Category: Microbiology Authors: Ren L, Chang X, Jiang F, Kan W, Qu Z, Qiu X, Fang C, Peng F Tags: Int J Syst Evol Microbiol Source Type: research

Thiogranum longum gen. nov., sp. nov., a novel obligately chemolithoautotrophic sulfur-oxidizing bacterium of the family Ectothiorhodospiraceae isolated from a hydrothermal field on Suiyo Seamount, and an emended description of the genus Thiohalomonas.
Abstract A novel obligately chemolithoautotrophic sulfur-oxidizing bacterial strain, designated strain gps52(T), was isolated from a rock sample collected near the hydrothermal vents of the Suiyo Seamount in the Pacific Ocean. The cells possessed a Gram-negative type cell wall and contained menaquinone-8(H4) and menaquinone-9(H4) as respiratory quinones, and C16:1ω7cis, C16:0, and C18:1ω7cis as major cellular fatty acids. Neither storage compounds nor extensive internal membranes were observed in the cells. Strain gps52T grew using carbon dioxide fixation and oxidation of inorganic sulfur compounds with oxygen as...
Source: International Journal of Systematic and Evolutionary Microbiology - October 21, 2014 Category: Microbiology Authors: Mori K, Suzuki KI, Yamaguchi K, Urabe T, Hanada S Tags: Int J Syst Evol Microbiol Source Type: research

The association between infections and chemotherapy interruptions among cancer patients: prospective cohort study
We examined causes for delay or cancellation of planned chemotherapy, focusing on mild respiratory infections during the winter. (Source: Journal of Infection)
Source: Journal of Infection - October 21, 2014 Category: Infectious Diseases Authors: Ahmed Taha, Inbal Vinograd, Ali Sakhnini, Noa Eliakim-Raz, Laura Farbman, Rina Baslo, Salomon M. Stemmer, Anat Gafter-Gvili, Leonard Leibovici, Mical Paul Source Type: research