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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Caffeine inhibits TGF{beta} activation in epithelial cells, interrupts fibroblast responses to TGF{beta}, and reduces established fibrosis in ex vivo precision-cut lung slices
Caffeine is a commonly used food additive found naturally in many products. In addition to potently stimulating the central nervous system caffeine is able to affect various systems within the body including the cardiovascular and respiratory systems. Importantly, caffeine is used clinically to treat apnoea and bronchopulmonary dysplasia in premature babies. Recently, caffeine has been shown to exhibit antifibrotic effects in the liver in part through reducing collagen expression and deposition, and reducing expression of the profibrotic cytokine TGFβ. The potential antifibrotic effects of caffeine in the lung have no...
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Tatler, A. L., Barnes, J., Habgood, A., Goodwin, A., McAnulty, R. J., Jenkins, G. Tags: Bronchopulmonary dysplasia, Open access, Child health, Infant health, Neonatal health, Airway biology Research letter Source Type: research

Time to first antibiotic and mortality in adults hospitalised with community-acquired pneumonia: a matched-propensity analysis
A matched-propensity analysis of national data from the British Thoracic Society community-acquired pneumonia audit was conducted (n=13 725). Overall, time to first antibiotic (TFA) was ≤4 h in 63%. Adjusted 30-day inpatient (IP) mortality was lower for adults with TFA ≤4 h compared with TFA >4 h (adjusted OR 0.84, 95% CI 0.74 to 0.94; p=0.003). Increasing TFA was associated with greater OR of 30-day IP mortality (p value for trend=0.001), but no TFA threshold was evident. Although we found an association between TFA and mortality, we cannot say whether this is causal or whether TFA might just ...
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Daniel, P., Rodrigo, C., Mckeever, T. M., Woodhead, M., Welham, S., Lim, W. S., on behalf of the British Thoracic Society Tags: Epidemiologic studies, Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine) Chest clinic Source Type: research

A case of behavioural hyperventilation associated with severe central sleep apnoea and follow-up management
YL (Junior Doctor): A 36-year-old man was observed by his wife to have irregular breathing with sighs followed by recurrent episodes of prolonged breathing cessation while falling asleep. The longest witnessed pause lasted approximately 3 min and during this time his lips became cyanotic. The patient was unaware of these episodes until his wife informed him. No wheezing, stridor, cough, gurgle or vomiting was observed during these episodes. A detailed interview revealed that the patient had a history of obstructive sleep apnoea and inferior turbinate hypertrophy and had undergone an electrocoagulation operation on the...
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Li, Y., Weed, J. G., Ren, R., Sun, Y., Zou, K., Lu, L., Tang, X. Tags: Sleep disorders (neurology), Drugs misuse (including addiction), Airway biology, Cystic fibrosis, Lung function, Sleep disorders (respiratory medicine), Radiology (diagnostics) Chest clinic Source Type: research

Persistent tachypnoea in an infant with cystic lung lucencies on CT scan
A 1 year and 8 months old boy, with mild motor developmental delay and right hemiparesis following a perinatal brain injury, was brought with a history of fast breathing and cough for 2 months and low-grade fever of 10 days duration. He was second born to non-consanguineously wed parents by spontaneous vaginal delivery with delayed cry at birth and neonatal intensive care unit stay for 10 days. There was no exposure to cigarette smoke. On examination there was mild central cyanosis with pan digital clubbing; pulse rate was 102 per minute; respiratory rate was 44 per minute; oxygen saturation of 89%...
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Kalasekhar, V., Nithiya, S., Chandrasekaran, V., Gulati, R., Jacob, S. E., Dubashi, B. Tags: Images in Thorax, Drugs: infectious diseases, Chemotherapy, Child health, Airway biology, Interstitial lung disease, Radiology (diagnostics), Health education, Smoking, Tobacco use, Tobacco use (youth) Chest clinic Source Type: research

Multiple giant bullae of the lung mimicking massive pneumothorax in a patient with osteogenesis imperfecta
A 60-year-old Caucasian man was admitted to our emergency department with progressive dyspnoea, chronic cough and general asthenia. Physical examination revealed lack of left chest wall motion and absent breath sounds over the left hemithorax. Vital signs were stable with a heart rate of 90 bpm, blood pressure of 120/70 mm Hg, respiratory rate of 20 breaths per minute and oxygen saturation by pulse oximetry of 95% while breathing room air. The patient reported being an active smoker with a 40 pack-year smoking history. He also had a history of type IV osteogenesis imperfecta, a connective tissue pathology th...
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Chiappetta, M., Nachira, D., Porziella, V., Vita, M. L., Margaritora, S. Tags: Images in Thorax, Emergency medicine, Journalology, Airway biology, Cardiothoracic surgery, Radiology (diagnostics), Ethics, Health education, Smoking, Tobacco use Chest clinic Source Type: research

What's hot that the other lot got
In this study (Lancet Resp Med 2016. pii: S2213-2600(16)00067-9), the authors undertook a pooled post hoc... (Source: Thorax)
Source: Thorax - May 13, 2016 Category: Respiratory Medicine Authors: Lee, C. Tags: Lung infection, Clinical trials (epidemiology), Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, TB and other respiratory infections, Venous thromboembolism, Interstitial lung disease, Pulmonary embolism Chest clinic Source Type: research

Co‐morbidities and cognitive status in a cohort of teenagers with asthma
ConclusionsIn adolescence, a higher cognitive status was associated with a higher rate of asthma. Chronic rhinitis was the most prevalent co‐morbidity and was found in one third of adolescent asthmatics. Other allergic diseases, chronic sinusitis, over and underweight, IBS, and thyroid disorders were also more prevalent in asthmatics. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 13, 2016 Category: Respiratory Medicine Authors: Shlomo Cohen, Neville Berkman, Elie Picard, Tali Levi, Estela Derazne, Dorit Tzur, Chaim Springer, Avraham Avital, Leon Joseph, Shmuel Goldberg Tags: Original Article: Asthma Source Type: research

COPD: A controversial disease?
Publication date: Available online 12 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): A. Araújo (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - May 13, 2016 Category: Respiratory Medicine Source Type: research

Unusual recovery of respiratory chain complex-III deficiency upon G-tube feeding and a cocktail
Publication date: June 2016 Source:Molecular Genetics and Metabolism Reports, Volume 7 Author(s): Josef Finsterer, Sinda Zarrouk-Mahjoub (Source: Molecular Genetics and Metabolism Reports)
Source: Molecular Genetics and Metabolism Reports - May 13, 2016 Category: Genetics & Stem Cells Source Type: research

Regulatory CD4+CD25+ T Cells Dampen Inflammatory Disease in Murine Mycoplasma Pneumonia and Promote IL-17 and IFN-γ Responses
by Adam N. Odeh, Jerry W. Simecka Mycoplasmas cause respiratory diseases characterized by persistent infection and chronic airway inflammation. Mycoplasma lung disease is immunopathologic, with CD4+ Th cells determining both disease severity and resistance to infection. Th2 cell responses promote immunopathology, while Th1 cells confer resistance to infection. However, regulatory CD4+ T cells may also have a role in the pathogenesis of mycoplasma respiratory diseases. We hypothesized Treg cells control the severity of the inflammatory lesions and may also promote persistence of infection. To examine this, BALB/c mice were...
Source: PLoS One - May 13, 2016 Category: Biomedical Science Authors: Adam N. Odeh Source Type: research

Mitochondrial H2O2 in Lung Antigen-Presenting Cells Blocks NF-κB Activation to Prevent Unwarranted Immune Activation
Publication date: Available online 12 May 2016 Source:Cell Reports Author(s): Anupriya Khare, Mahesh Raundhal, Krishnendu Chakraborty, Sudipta Das, Catherine Corey, Christelle K. Kamga, Kelly Quesnelle, Claudette St. Croix, Simon C. Watkins, Christina Morse, Timothy B. Oriss, Rachael Huff, Rachel Hannum, Prabir Ray, Sruti Shiva, Anuradha Ray Inhalation of environmental antigens such as allergens does not always induce inflammation in the respiratory tract. While antigen-presenting cells (APCs), including dendritic cells and macrophages, take up inhaled antigens, the cell-intrinsic molecular mechanisms...
Source: Cell Reports - May 13, 2016 Category: Cytology Source Type: research

Opioid overdose leading to intensive care unit admission: Epidemiology and outcomes
Conclusion Opioid overdose is a common cause of ICU admission and affects a relatively young population. Most have respiratory failure requiring mechanical ventilation. It is associated with a relatively high inhospital mortality. Coingestions appear to have an impact on outcomes. (Source: Journal of Critical Care)
Source: Journal of Critical Care - May 13, 2016 Category: Gastroenterology Source Type: research

Infections in symptomatic travelers returning from the Arabian peninsula to France: a retrospective cross-sectional study
Many returning travelers from the Arabian peninsula to France are Hajj pilgrims, often presenting with respiratory infections, which is of particular concern for older travelers with comorbidities [1]. Millions of Muslims from over 180 countries participate in the pilgrimage to Mecca, Saudi Arabia annually. The Hajj has been linked to an acquisition to viral respiratory pathogens[2,3]. After the MERS-Coronavirus outbreak in 2012, there was widespread fear of a massive outbreak[4], resulting in the Saudi Arabian government restricting numbers of pilgrims[5]. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - May 13, 2016 Category: Infectious Diseases Authors: Karolina Griffiths, Remi Charrel, Jean-Christophe Lagier, Antoine Nougairede, Fabrice Simon, Philippe Parola, Philippe Brouqui, Philippe Gautret Tags: Correspondence Source Type: research

How should we approach Aspergillus in lung secretions of patients with COPD?
Abstract Aspergillus spp. is frequently isolated in respiratory samples from patients with severe COPD; however, the clinical significance of this mold is unclear and its presence may indicate temporary passage, benign chronic carriage, or onset of invasive disease. The definitive diagnosis of pulmonary aspergillosis in COPD patients is often difficult owing to the lack of specific clinical and radiological signs. However, retrospective studies show the risk for developing pulmonary aspergillosis in older patients with severe COPD, and a high number of comorbidities who have received treatment with corticosteroids ...
Source: Revista Espanola de Quimioterapia - May 13, 2016 Category: Drugs & Pharmacology Authors: Barberán J, Candel FJ, Arribi A Tags: Rev Esp Quimioter Source Type: research

Design and evaluation of a ubiquitous chest-worn cardiopulmonary monitoring system for healthcare application: a pilot study
This study presents a miniature wearable cardiopulmonary monitoring system called “Smart Chest Strap,” which consists of an elastic band worn around the user’s chest with integrated sensors, a physiological signals acquisition unit, and a mobile phone. The physiological signals including electrocardiogram, respiratory inductance plethysmograph, and accelerations (ACC) are sampled, digitalized, stored, and simultaneously transmitted to a mobile phone via Bluetooth. A medical validation test with participants performing discontinuous incremental treadmill (0–12 km/h) exercise was conducted. The results indicate near...
Source: Medical and Biological Engineering and Computing - May 13, 2016 Category: Biomedical Engineering Source Type: research

Effect of conventional physical therapy and Pilates in functionality, respiratory muscle strength and ability to exercise in hospitalized chronic renal patients: A randomized controlled trial.
CONCLUSION: Both interventions, conventional physical therapy and Pilates, showed improvements and there is no difference between them. Therefore both can be used in chronic renal patients. PMID: 27178843 [PubMed - as supplied by publisher] (Source: Clinical Rehabilitation)
Source: Clinical Rehabilitation - May 13, 2016 Category: Rehabilitation Authors: Sarmento LA, Pinto JS, da Silva AP, Cabral CM, Chiavegato LD Tags: Clin Rehabil Source Type: research

In Vitro Antiviral Activity of Germacrone Against Porcine Reproductive and Respiratory Syndrome Virus.
In this study, we exploited whether germacrone has the potential to inhibit PRRSV infection. Our results showed that the germacrone significantly inhibited replication of PRRSV in vitro and repressed the synthesis of viral RNA and protein. However, it did not block PRRSV binding and entry. Further studies confirmed that germacrone impaired PRRSV replication at an early stage, and inhibited infection of both classic and highly pathogenic type II PRRSV strains. Collectively, our findings imply that the germacrone has the potential to be used as an anti-PRRSV drug. PMID: 27178541 [PubMed - as supplied by publisher] (Sourc...
Source: Current Microbiology - May 13, 2016 Category: Microbiology Authors: Feng J, Bai X, Cui T, Zhou H, Chen Y, Xie J, Shi Q, Wang H, Zhang G Tags: Curr Microbiol Source Type: research

Extracorporeal membrane oxygenation after intravenous injection of paraffin oil.
We present a rare cause of acute respiratory distress syndrome (ARDS) due to an accidental intravascular injection of paraffin oil. While there is no specific therapy, we decided to support the patient with veno-venous extracorporeal membrane oxygenation (V-V ECMO) to allow the ARDS to resolve. A previously healthy 30-year-old man was admitted to the Emergency Department with acute onset respiratory distress following an injection with paraffin oil for cosmetic purposes. In 36 hours, the patient developed severe ARDS and respiratory support with V-V ECMO was initiated. The patient was successfully weaned from ECMO on day 1...
Source: Perfusion - May 13, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Pasgaard T, Huynh AT, Gjedsted J Tags: Perfusion Source Type: research

Vitamin D deficiency and lower respiratory tract infections in children: a systematic review and meta-analysis of observational studies.
The objective of this systematic review was to assess the prevalence of vitamin D deficiency in children with LRTI, and to evaluate the correlation between vitamin D levels and the incidence and severity of LRTI. A total of 12 studies enrolling 2279 participants were included in our analysis. Children with LRTI were found to have significantly lower mean vitamin D levels as compared to controls There was likewise a correlation between vitamin D levels and incidence and severity of LRTI. Large randomised controlled trials are needed to evaluate effect of vitamin D supplementation for LRTI. PMID: 27178217 [PubMed - as su...
Source: Tropical Doctor - May 13, 2016 Category: Tropical Medicine Authors: Jat KR Tags: Trop Doct Source Type: research

Lowering the high rate of caesarean delivery in China: an experience from Shanghai.
CONCLUSIONS: A marked reduction in CD has occurred at an urban tertiary care centre as a result of efforts to reduce the high rate of caesarean delivery. No notable differences in neonatal outcomes were observed. TWEETABLE ABSTRACT: High rates of caesarean delivery can be lowered without increases in neonatal morbidity and mortality. PMID: 27173766 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)
Source: BJOG : An International Journal of Obstetrics and Gynaecology - May 13, 2016 Category: OBGYN Authors: Liu X, Lynch CD, Cheng WW, Landon MB Tags: BJOG Source Type: research

Combined Exercise and Inspiratory Muscle Training in Patients With Heart Failure: A SYSTEMATIC REVIEW AND META-ANALYSIS.
CONCLUSIONS: Combined exercise/IMT may improve maximal inspiratory pressure and quality of life in patients with HF and should be considered for inclusion in cardiac rehabilitation programs. PMID: 27182763 [PubMed - as supplied by publisher] (Source: Journal of Cardiopulmonary Rehabilitation and Prevention)
Source: Journal of Cardiopulmonary Rehabilitation and Prevention - May 13, 2016 Category: Rehabilitation Authors: Neto MG, Martinez BP, Conceição CS, Silva PE, Carvalho VO Tags: J Cardiopulm Rehabil Prev Source Type: research

Incidental pulmonary lymphangioleiomyomatosis in a patient with breast cancer.
PMID: 27185512 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - May 13, 2016 Category: Respiratory Medicine Authors: Gorospe Sarasúa L, Ayala-Carbonero AM, Fernández-Méndez MÁ Tags: Arch Bronconeumol Source Type: research

Eosinophilic pleural effusion as a manifestation of idiopathic hypereosinophilic syndrome.
PMID: 27185511 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - May 13, 2016 Category: Respiratory Medicine Authors: Lima Álvarez J, Peña Griñán N, Simón Pilo I Tags: Arch Bronconeumol Source Type: research

A novel mutation in FBXL4 in a Norwegian child with encephalomyopathic mitochondrial DNA depletion syndrome 13.
We report a novel missense variant, c.1442T > C (p.Leu481Pro), in FBXL4 (NM_012160.4) in a Norwegian boy with clinical, biochemical and cerebral MRI characteristics consistent with MTDPS13. The FBXL4 c.1442T > C (p.Leu481Pro) variant was not present in public databases, 149 Norwegian controls nor an in-house database containing whole exome sequencing data from 440 individuals, and it was predicted in silico to be deleterious to the protein function. Activities of MRC enzymes were normal in muscle tissue (complexes I-IV) and cultured skin fibroblasts (complexes I-V) from the patient, but mtDNA depletion was confir...
Source: European Journal of Medical Genetics - May 13, 2016 Category: Genetics & Stem Cells Authors: Barøy T, Pedurupillay CR, Bliksrud YT, Rasmussen M, Holmgren A, Vigeland MD, Hughes T, Brink M, Richard, Nedregaard B, Strømme P, Frengen E, Misceo D Tags: Eur J Med Genet Source Type: research

Molecular epidemiology, phylogeny and evolution of Legionella.
We report the newest knowledge regarding the phylogeny and the evolution of Legionella and then focus on virulence evolution of those Legionella species that are known to have the capacity to infect humans. Finally, we discuss the evolutionary forces and adaptation mechanisms acting on the Dot/Icm system itself as well as the role of mobile genetic elements (MGE) encoding T4ASSs and of gene duplications in the evolution of Legionella and its adaptation to different hosts and lifestyles. PMID: 27180896 [PubMed - as supplied by publisher] (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - May 13, 2016 Category: Genetics & Stem Cells Authors: Khodr A, Kay E, Gomez-Valero L, Ginevra C, Doublet P, Buchrieser C, Jarraud S Tags: Infect Genet Evol Source Type: research

RSV neutralization by palivizumab, but not by monoclonal antibodies targeting other epitopes, is augmented by Fc gamma receptors.
Abstract Palivizumab efficiently blocks respiratory syncytial virus (RSV) infection in vitro. However, virus neutralization assays generally omit Fc region-mediated effects. We investigated the neutralization activity of RSV-specific monoclonal antibodies on cells with Fc receptors. Subneutralizing concentrations of antibodies resulted in antibody-dependent enhancement of RSV infection in monocytic cells. Contrary to antibodies targeting other epitopes, the neutralization by palivizumab was augmented in cells with Fc receptors. This unrecognized characteristic of palivizumab may be relevant for its performance in v...
Source: Antiviral Research - May 13, 2016 Category: Virology Authors: van Mechelen L, Luytjes W, de Haan CA, Wicht O Tags: Antiviral Res Source Type: research

Neonatal anoxia leads to time dependent progression of mitochondrial linked apoptosis in rat cortex and associated long term sensorimotor deficits.
In conclusion, anoxia injury leads to progressive activation of mitochondrial events leading to increase in apoptotic cell death following secondary pathological insult. Therefore, strategies in limiting mitochondrial-linked apoptosis during the secondary insult input process may be useful in treatment of long term sensorimotor deficits following anoxia. PMID: 27184438 [PubMed - as supplied by publisher] (Source: International Journal of Developmental Neuroscience)
Source: International Journal of Developmental Neuroscience - May 13, 2016 Category: Neuroscience Authors: Samaiya PK, Narayan G, Kumar A, Krishnamurthy S Tags: Int J Dev Neurosci Source Type: research

Vaccines against respiratory syncytial virus: The time has finally come.
Abstract Respiratory syncytial virus causes a significant public health burden, particularly in very young infants and the frail elderly. The legacy of enhanced RSV disease (ERD) from a whole formalin-inactivated RSV vaccine, and the complex biology of the virus and the neonate have delayed the development of effective vaccines. However, new insights into factors associated with ERD and breakthroughs in understanding the antigenic structure of the fusion (F) glycoprotein have increased optimism that vaccine development is possible. This has led to investment of time and resources by industry, regulatory authorities...
Source: Vaccine - May 13, 2016 Category: Allergy & Immunology Authors: Graham BS Tags: Vaccine Source Type: research

Vaccination evokes gender-dependent protection against tularemia infection in C57BL/6Tac mice.
In this study, a role for gender in vaccine-induced protection following Ft challenge is identified for the first time. In the present study, mucosal vaccination with inactivated Ft (iFt) LVS elicited gender-based protection in C57BL/6Tac mice against respiratory challenge with Ft LVS. Specifically, vaccinated male mice were more susceptible to subsequent Ft LVS challenge. This increased susceptibility in male mice correlated with increased bacterial burden, increased tissue inflammation, and increased proinflammatory cytokine production late in post-challenge infection. In contrast, improved survival of iFt-vaccinated fem...
Source: Vaccine - May 13, 2016 Category: Allergy & Immunology Authors: Sunagar R, Kumar S, Franz BJ, Gosselin EJ Tags: Vaccine Source Type: research

Advanced Uses of Pulse Oximetry for Monitoring Mechanically Ventilated Patients.
Abstract Pulse oximetry is an undisputable standard of care in clinical monitoring. It combines a spectrometer to detect hypoxemia with a plethysmograph for the diagnosis, monitoring, and follow-up of cardiovascular diseases. These pulse oximetry capabilities are extremely useful for assessing the respiratory and circulatory status and for monitoring of mechanically ventilated patients. On the one hand, the key spectrography-derived function of pulse oximetry is to evaluate a patient's gas exchange that results from a particular ventilatory treatment by continuously and noninvasively measuring arterial hemoglobin s...
Source: Anesthesia and Analgesia - May 13, 2016 Category: Anesthesiology Authors: Tusman G, Bohm SH, Suarez-Sipmann F Tags: Anesth Analg Source Type: research

Pneumonia caused by Bordetella bronchiseptica in two HIV-positive patients.
CONCLUSION: BB should be included in the etiology of pneumonia in immunodeficient HIV patients. As far as we know, these two were the first cases of pneumonia due to BB to occur in this university hospital. PMID: 27191248 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - May 13, 2016 Category: Journals (General) Authors: Rampelotto RF, Hörner A, Hörner C, Righi R, Hörner R Tags: Sao Paulo Med J Source Type: research

System Design Verification for Closed Loop Control of Oxygenation With Concentrator Integration.
CONCLUSIONS: These tests verify a system that provides closed loop control of oxygenation while integrating time-coordinated pulse-doses from an oxygen concentrator. This allows the most efficient use of resources in austere environments. PMID: 27168570 [PubMed - as supplied by publisher] (Source: Military Medicine)
Source: Military Medicine - May 12, 2016 Category: Global & Universal Tags: Mil Med Source Type: research

How can Adherence to Asthma Medication be Enhanced? Triangulation of Key Asthma Stakeholders' Perspectives.
CONCLUSION: Asthma medication adherence is a complex process and successful interventions aimed at improving it would benefit from: (a) making an effort to understand patients' experiences and negotiate the treatment regimen, rather than imposing recommendations; (b) considering treatment as a shared responsibility involving the patient, the healthcare professional(s), and the patients' social networks; PMID: 27167629 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 12, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

San Francisco childcare centers' preparedness in the prevention and management of asthma among preschool-aged children.
DISCUSSION: There is room for improvement in the asthma care and preparedness of childcare centers. The 3 areas in which centers performed poorly (appropriate asthma medication management, use of asthma action plans, and presence of appropriate asthma policies) suggest that closer collaboration between clinicians and childcare centers may be a key to improving asthma management for young children. PMID: 27164036 [PubMed - as supplied by publisher] (Source: Journal of Asthma)
Source: Journal of Asthma - May 12, 2016 Category: Respiratory Medicine Tags: J Asthma Source Type: research

Exercise responses are related to structural lung damage in CF pulmonary disease
ConclusionsExercise testing is more sensitive than spirometry to detect structural changes in CF lungs. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 12, 2016 Category: Respiratory Medicine Authors: Elpis Hatziagorou, Asterios Kampouras, Vasiliki Avramidou, Vasiliki Georgopoulou, Fotis Kirvasilis, Kalliopi Kontouli, Helge Hebestreit, John Tsanakas Tags: Original Article: Cystic Fibrosis Source Type: research

Image-Guided Pleural Biopsy: Issue of the Expertise and Availability of the Resources
Respiration (Source: Respiration)
Source: Respiration - May 12, 2016 Category: Respiratory Medicine Source Type: research

Effectiveness of PCR and Immunofluorescence Techniques for Detecting Human Cytomegalovirus in Blood and Bronchoalveolar Lavage Fluid.
Authors: Roży A, Duk K, Szumna B, Skrońska P, Gawryluk D, Chorostowska-Wynimko J Abstract Current diagnostic methods allow a rapid and reliable detection of active human cytomegalovirus (hCMV) infection by identifying the presence of pp65 CMV antigen or CMV DNA in peripheral blood and affected organs. The goal of this study was to evaluate the effectiveness of CMV detection in blood and organ-specific biological material, such as bronchoalveolar lavage fluid (BALF), by comparing two standard diagnostic methods, immunofluorescence (IF) and the real-time polymerase chain reaction (PCR). We evaluated 25 patients wit...
Source: Advances in Experimental Medicine and Biology - May 12, 2016 Category: Research Tags: Adv Exp Med Biol Source Type: research

Primary pleural intermediate hemangioendothelioma with pleural effusion as the only manifestation.
Authors: Jiang J, Li Y, Hu C, Zhou J, Yang H, Cao L, Deng P Abstract Intermediate hemangioendothelioma is a group of rare tumors of vascular origin that show a borderline biological behavior and commonly arise in extremities, trunk, head or neck. Intermediate hemangioendothelioma originating in pleura is extremely rare. Herein we describe a case of primary pleural intermediate hemangioendothelioma in a 48-year-old man presenting with pleural effusion only. The patient was diagnosed by pleura biopsy and immunohistochemistry in our hospital. Even though neither systemic chemotherapy nor surgery was applied, he got re...
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Concomitant off-pump coronary artery bypass grafting and total thyroidectomy for a large retrosternal goitre: a case report and review of the literature.
Authors: Lampridis S, Lau MC, Mhandu P, Parissis H Abstract A 76-year-old male presented with angina and a large retrosternal goitre causing marked dyspnoea. Coronary angiography revealed triple vessel disease and moderately impaired left ventricular function. CT imaging demonstrated a substantial multinodular goitre extending into the posterior mediastinum to the level of the carina, with associated compression of the trachea and oesophagus. Preoperative thyroid function tests showed euthyroid state. The patient subsequently underwent off-pump coronary artery bypass grafting (OPCABG) ×2 with concomitant total thy...
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Malignant transformation of alveolar adenoma to papillary adenocarcinoma: a case report.
We present a case involving alveolar adenoma (AA) comprising a malignant component. An 83-year-old man was referred with a solitary pulmonary nodule, which was diagnosed as adenocarcinoma (AC) by transbronchial biopsy. Resected specimen after left S1+2 segmentectomy revealed that the tumor comprised two histologically distinct areas-a central multi-cystic area (AA) and a surrounding area (papillary AC). Careful examination clarified that the borderline lesion showed intermediate mindbomb homolog-1 index and cytological atypia with low papillary growth, suggesting the possibility of malignant transformation of the AA. The m...
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

A report of three cases of surgical removal of esophageal schwannomas.
Authors: Chen X, Li Y, Liu X, Fu H, Sun H, Zhang R, Wang Z, Zheng Y Abstract Esophageal schwannomas are rarely observed, and the most frequent presenting symptom is dysphagia. In such cases, esophageal endoscopy shows a mucosal protrusion with normal esophageal mucosa. Esophagography shows a protruding smooth mass in the middle thoracic esophagus. Both fluorodeoxyglucose (FDG) positron emission tomography (PET) and endoscopic ultrasonography-fine needle aspiration (EUS-FNA) are limited for diagnosing the case. Diagnosis of this condition before surgery is difficult. The most common and effective treatment is enucle...
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Symptomatic pericardial schwannoma treated with video-assisted thoracic surgery: a case report.
We present a rare case of pericardial schwannoma confirmed by video-assisted thoracoscopic resection. PMID: 27162698 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

A heterochronic genetic change from an EGFR mutation to an ALK rearrangement in a patient with lung adenocarcinoma: a case report.
Authors: Shiroyama T, Tamiya M, Hayama M, Nishihara T, Nishida T, Tanaka A, Morishita N, Suzuki H, Okamoto N, Kawahara K, Hirashima T Abstract An 87-year-old man with postoperative recurrent lung adenocarcinoma was treated with gefitinib. At the beginning of treatment, surgically resected archived tumor tissue revealed a deletion in exon 19 of the EGFR gene, but no ALK gene rearrangement. After gefitinib treatment for 9 months, the disease progressed. Bronchoscopic rebiopsy was used to evaluate resistance mechanisms, and revealed lung adenocarcinoma with wild-type EGFR genes and a newly emerged ALK gene rearrangeme...
Source: Journal of Thoracic Disease - May 12, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research