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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization.
Abstract Post-infectious immunity to respiratory syncytial virus (RSV) infection results in limited protection as evidenced by the high rate of infant hospitalization in the face of high titer, maternally derived RSV-specific antibodies. By contrast, RSV fusion (F) glycoprotein antigenic site II humanized monoclonal antibodies, palivizumab and motavizumab, have been shown to reduce RSV-related hospitalization in infants. Immunogenicity and efficacy studies were conducted in cotton rats comparing a recombinant RSV F nanoparticle vaccine with palivizumab and controlled with live RSV virus intranasal immunization and,...
Source: Vaccine - September 27, 2014 Category: Allergy & Immunology Authors: Raghunandan R, Lu H, Zhou B, Xabier MG, Massare MJ, Flyer DC, Fries LF, Smith GE, Glenn GM Tags: Vaccine Source Type: research

Design, performance characteristics and application examples of a new 4D motion platform.
Abstract In this publication, a three-dimensionally movable motion phantom is described and its performance characteristics are evaluated. The intended primary fields of application for the phantom are the quality assurance (QA) of respiratory motion management devices in radiation therapy (RT) like gating or tumour tracking systems, training for clinical use of these techniques, and related 4DRT research. Considering especially the QA aspect, the phantom was designed as a motion platform that can be equipped with an appropriate add-on like standard QA phantoms for dosimetric measurements. The platform is driven by...
Source: Zeitschrift fur Medizinische Physik - September 27, 2014 Category: Radiology Authors: Grohmann C, Frenzel T, Werner R, Cremers F Tags: Z Med Phys Source Type: research

Anesthetic considerations in Demons-Meigs’ syndrome: a case report
Conclusions Demons-Meigs’ syndrome is a benign disease with a good prognosis. Respiratory and hemodynamic problems and abdominal hypertension are the main anesthetic risks of this syndrome. Good management of these risks is necessary to preserve the prognosis. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 27, 2014 Category: Journals (General) Source Type: research

Optic neuritis associated with influenza B virus meningoencephalitis
Most of the influenza virus infection symptoms are respiratory or gastrointestinal, associated with a good prognosis. However, several neurological complications, ranging from mild manifestations to acute necrotising encephalopathy have been reported [1–3]. Optic neuritis (ON) consists of the optic nerve inflammation, resulting in sudden painful vision loss or impaired function of the affected eye [4]. It has been associated with influenza vaccination both in children and adults [5]. Anecdotally, ON was reported after an influenza A virus infection, too [6]. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - September 27, 2014 Category: Virology Authors: F.A. Vianello, S. Osnaghi, E.A. Laicini, G.P. Milani, G. Tardini, A.M. Cappellari, G. Lunghi, C.V. Agostoni, E.F. Fossali Tags: Case Report Source Type: research

Building capacity to improve respiratory care: the education strategy of the International Primary Care Respiratory Group 2014-2020.
Abstract Significant attention has been given to the global burden of noncommunicable diseases including respiratory diseases and the potential of primary care to address this challenge. The International Primary Care Respiratory Group (IPCRG) has a potentially significant role to build capacity through research and education in a complex global network with varying degrees of capability. In this paper we outline a comprehensive strategy, which revisits the IPCRG's educational role, our aims, audiences and approach in this context. The paper was developed through a collaborative process involving experts in global ...
Source: Respiratory Care - September 26, 2014 Category: Respiratory Medicine Authors: McDonnell J, Correira De Sousa J, Baxter N, Pinnock H, Roman-Rodriquez M, van der Molen T, Williams S Tags: NPJ Prim Care Respir Med Source Type: research

Influence of lung function on course of disease and response to antibiotic therapy in adult primary care patients with acute cough: a post hoc analysis of patients enrolled in a prospective multicentre study.
Conclusions:In adult patients with acute cough, lung function abnormalities were neither significantly associated with course of disease nor did they modify the effect of antibiotics. PMID: 25253123 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 26, 2014 Category: Respiratory Medicine Authors: van Erp N, Little P, Stuart B, Moore M, Thomas M, Butler CC, Hood K, Coenen S, Goossens H, Leven M, Verheij TJ Tags: NPJ Prim Care Respir Med Source Type: research

Improved arterial blood oxygenation following intravenous infusion of cold supersaturated dissolved oxygen solution.
CONCLUSIONS: A cold, supersaturated dissolved oxygen solution may be intravenously administered to improve arterial blood oxygenation and ventilation parameters and induce a mild therapeutic hypothermia in a porcine model. PMID: 25249764 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - September 26, 2014 Category: Respiratory Medicine Authors: Grady DJ, Gentile MA, Riggs JH, Cheifetz IM Tags: Clin Med Insights Circ Respir Pulm Med Source Type: research

Early lung ultrasonography predicts the occurrence of acute respiratory distress syndrome in blunt trauma patients
Conclusions LUS on admission identifies patients at risk of developing ARDS after blunt trauma. In addition, LUS allows rapid and accurate diagnosis of common traumatic thoracic injuries. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 26, 2014 Category: Intensive Care Source Type: research

Extubation to facilitate mother–baby bonding in refractory acute respiratory distress syndrome
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 26, 2014 Category: Intensive Care Source Type: research

Comment on Adamzik et al.: An increased alveolar CD4 + CD25 + Foxp3 + T-regulatory cell ratio in acute respiratory distress syndrome is associated with increased 30-day mortality
(Source: Intensive Care Medicine)
Source: Intensive Care Medicine - September 26, 2014 Category: Intensive Care Source Type: research

Fibrotic hypersensitivity pneumonitis
Abstract Fibrotic hypersensitivity pneumonitis (FHP) is a specific form of HP defined by chest imaging evidence or pathologic evidence of fibrosis or scarring. Fibrotic HP appears to be irreversible, is often progressive and frequently indistinguishable from other forms of chronic fibrosing interstitial lung diseases (ILD), in particular idiopathic pulmonary fibrosis (IPF). Accurate diagnosis is a challenge given the diverse and often nonspecific clinicoradiologic patterns, heterogenous clinical course, and a frequent lack of a readily recognizable temporal relationship between exposure to an inciting antigen (IA)...
Source: Current Respiratory Care Reports - September 26, 2014 Category: Respiratory Medicine Source Type: research

Management of chronic rhinosinusitis
Abstract Chronic rhinosinusitis (CRS) is a prevalent inflammatory disorder of the paranasal mucosa, which encompasses a complex and heterogeneous disease population with variable pathophysiologic, host, and environmental etiologies. Due to this variability and an evolving understanding of its underlying etiology, successful medical and surgical management cannot be standardized and remains challenging. Medical management remains the first line strategy for this chronic condition with no known cure. Surgical therapy remains an important adjunct intervention when medical therapy fails to control the disease adequate...
Source: Current Respiratory Care Reports - September 26, 2014 Category: Respiratory Medicine Source Type: research

Correlations Between Small Airway Function, Ventilation Distribution, and Functional Exercise Capacity in COPD Patients
Conclusions In patients with COPD, our findings suggest that the ventilation inhomogeneity impacts the functional exercise capacity, the degree of dyspnea, and health status. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Survival Benefit of CPAP Favors Hypercapnic Patients with the Overlap Syndrome
(Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Idiopathic Pleuroparenchymal Fibroelastosis is Characterized by an Elevated Serum Level of Surfactant Protein-D, but Not Krebs Von Den Lungen-6
Conclusions In IPPFE, SP-D might tend to be elevated, while KL-6 was within a normal range. Further study is required to determine the pathogenesis and clinical significance of the elevated SP-D in IPPFE. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Impact of Long-Acting Bronchodilators and Exposure to Inhaled Corticosteroids on Mortality in COPD: A Real-Life Retrospective Cohort Study
Conclusion In patients exposed to ICS, concomitant use of LAMA alone as dual therapy or in combination with LABA as triple therapy were associated with reductions in all-cause mortality, while concomitant use of LABA without LAMA conferred no reduction. Moreover, only triple therapy was found to confer benefits on cardiovascular mortality. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

A Retrospective Study of Prognostic Factors in Patients with Interstitial Pneumonia Receiving Long-Term Oxygen Therapy
Conclusions After the initiation of LTOT, patients with IIP had poor prognosis regardless of the patterns classified with HRCT, while those with CVD-IP survived longer. Male gender, low body mass index, and the absence of CVD were the independent negative prognostic factors in patients with interstitial pneumonia receiving LTOT. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Relationship of Serum Gamma-Glutamyltransferase Levels with Pulmonary Function and Chronic Obstructive Pulmonary Disease
Conclusions In conclusion, in non-smokers serum GGT levels can be used to detect individuals at high risk of decreased pulmonary function and/or COPD. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

EGFR Mutation Testing Practice in Advanced Non-Small Cell Lung Cancer
Conclusions EGFR testing is requested in Israel routinely by most treating Oncologists for all advanced NSCLC patients, regardless of histology. In most cases, systemic treatment is deferred until the results of this test are received. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Active Asthma and the Prevalence of Physician-Diagnosed COPD
Conclusions Among adults with a history of asthma, active manifestations of asthma may play an important role in the epidemiology of COPD. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Association of CYP1B1 Leu432Val Polymorphism and Lung Cancer Risk: An Updated Meta-Analysis
Conclusions Our results suggest that the CYP1B1 Leu432Val polymorphism acts as a risk factor for the carcinogenesis of lung cancer. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Effect of CPAP on Long-Term Mortality in Overlap Syndrome: Is Hypercapnic the Best Appropriate Determinant?
Abstract Overlap syndrome and represents a complex clinical condition in pulmonary medicine. We discuss in this letter factors related with mortality after long-term effects CPAP and key differences between hypercapnic versus hypoxemic overlap patients. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

The Ability of Volumetric Capnography to Distinguish between Chronic Obstructive Pulmonary Disease Patients and Normal Subjects
Conclusion Vm25-50, dC2/dV, or dC3/dV alone are valuable for differentiating COPD patients and normal subjects, but more powerful are the combinations of Vm25-50, dC2/dV, and dC3/dV, the ratio of dC2/dV to dC3/dV (SR23), dead space according to the Bohr method (VDB), and dead space according to the Wolff and Brunner methods (PIE). (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Postnatal Development of Lung T Lymphocytes in a Porcine Model
Conclusions These results suggest that in healthy animals the lung lobes behave as a homogeneous immune organ. T cells were detected in very low percentages at birth and in adult life, which may explain the high susceptibility to respiratory infections both early and later in life. Postweaning antigenic challenges and endocrine and sexual maturity at 3M had important effects on the development of the mucosal immune system. It was also evident that changes at mucosal sites were poorly correlated with PBMC and LN. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Prediction of Pulmonary Restriction from Forced Vital Capacity in Elderly is Similar Using GLI and ERS Equations
Conclusions In conclusion, both sets of equations similarly predicted a pulmonary restriction in older subjects. The high negative predictive value of the GLI equations thus allows for static lung volume measurement to be avoided in older patients when the FCV exceeds the LLN whatever the predicted equation used. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Developing a Reference of Normal Lung Sounds in Healthy Peruvian Children
Conclusions Lung sound extracted features varied significantly with child characteristics and lung site. A comparison with adult studies revealed differences in the extracted features for children. While sound-reduction techniques will improve analysis, we offer a novel, reproducible tool for sound analysis in real-world environments. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Response–Dose Ratio is a Surrogate of Cumulative Provocative Dosage for Bronchial Provocation Tests in Asthma
Conclusions RDR is a surrogate of PD20FEV1 for BPTs in asthma. This finding was not modified by different asthma control levels or the types of bronchoprovocants. (Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Pulmonologist Versus Radiologist Interpretation of Cystic Fibrosis on CT Imaging
(Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Neonatal Spontaneous Pneumomediastinum
(Source: Lung)
Source: Lung - September 26, 2014 Category: Respiratory Medicine Source Type: research

Plasma neuropeptide Y levels in Chinese patients with primary insomnia
Conclusions Our findings suggest that NPY system may involve in the pathophysiological process of primary insomnia. Further studies are warranted to determine the causal relationship between low plasma NPY level and primary insomnia disorder. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 26, 2014 Category: Respiratory Medicine Source Type: research

Distribution of airway smooth muscle remodelling in asthma: Relation to airway inflammation
ConclusionsDistinct distributions of ASM remodelling are seen in asthma. Pathology limited to the small airways was uncommon. Increased thickness of the ASM layer was associated with airway remodelling and eosinophilia, but not neutrophilia. These data support the presence of distinct pathological phenotypes based on the site of increased ASM. (Source: Respirology)
Source: Respirology - September 26, 2014 Category: Respiratory Medicine Authors: John G. Elliot, Robyn L. Jones, Michael J. Abramson, Francis H. Green, Thais Mauad, Karen O. McKay, Tony R. Bai, Alan L. James Tags: Original Article Source Type: research

Lingua–epiglottis position predicts glossopharyngeal obstruction in patients with obstructive sleep apnea hypopnea syndrome
The objective of the study was to investigate the relationship between lingua–epiglottis position and glossopharyngeal obstruction in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). One hundred and four patients with OSAHS diagnosed by polysomnography (PSG) were enrolled. Lingua–epiglottis position was visualized using endoscopy and classified into three types. Spiral CT imaging of the upper respiratory tract was performed to measure the cross-sectional area and inner diameter of the glossopharyngeal airway. The PSG was repeated after nasopharyngeal tube insertion (NPT-PSG). The NPT-PSG results, CT-mea...
Source: European Archives of Oto-Rhino-Laryngology - September 26, 2014 Category: ENT & OMF Source Type: research

Prevalence and Impact of Unhealthy Weight in a National Sample of US Adolescents with Autism and Other Learning and Behavioral Disabilities
Abstract We estimated the prevalence of obesity, overweight, and underweight among US adolescents with and without autism and other learning and behavioral developmental disabilities (DDs) and assessed the health consequences of obesity among adolescents with DDs. From the 2008 to 2010 National Health Interview Survey, we selected 9,619 adolescents ages 12–17 years. Parent respondents reported weight, height, presence of DDs and health conditions. We calculated body mass index (BMI) and defined obesity, overweight, and underweight as ≥95th, ≥85th to <95th, and <5th percentiles, respectively, using es...
Source: Maternal and Child Health Journal - September 26, 2014 Category: Health Management Source Type: research

A new porcine reproductive and respiratory syndrome virus strain with highly conserved molecular characteristics in its parental and attenuated strains
In this study, PRRSV strain NT0801-F80 was derived from its parental isolate NT0801 by 80 passages in Marc-145 cells. Experimental infection of piglets clearly demonstrated that strain NT0801-F80 is less virulent than NT0801. However, whole genome sequencing showed that the genomes of the parental and attenuated strains are highly conserved compared with those of four other pairs of virulent parental/attenuated vaccine strains (VR2332 and RespPRRS MLV, JA142 and Ingelvac® ATP MLV, CH-1a and CH-1R, and JXA1 and JXAR). The attenuated strain NT0801-F80 has only 21 nucleotide changes, producing only 14 amino acid changes in N...
Source: Virus Genes - September 26, 2014 Category: Genetics & Stem Cells Source Type: research

Identification and genetic characterization of avian-origin H3N2 canine influenza viruses isolated from the Liaoning province of China in 2012
Abstract A total of 158 serum samples and 510 nasal swab specimens were collected between September 2010 and May 2012, from dogs exhibiting respiratory symptoms, in order to investigate the epidemiology of H3N2 canine influenza viruses (CIVs) in the Liaoning province of China. Serological surveillance demonstrated that 10.8 % (17/158) of serum samples were positive for H3N2 canine influenza. Two H3N2 influenza viruses, A/canine/Liaoning/27/2012 and A/canine/Liaoning/H6/2012, were isolated from pet dogs in 2012. Phylogenetic analysis indicated that the genes from these two viruses were closely related to those of...
Source: Virus Genes - September 26, 2014 Category: Genetics & Stem Cells Source Type: research

Occupational rhinitis due to steel welding fumes
We report a 26‐year‐old male with work‐related rhinitis symptoms as well as lower airways symptoms suggestive of occupational asthma and metal fume fever associated with exposure to steel welding fumes. The diagnosis of occupational rhinitis was confirmed by specific inhalation challenge. Am. J. Ind. Med. © 2014 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)
Source: American Journal of Industrial Medicine - September 26, 2014 Category: Occupational Health Authors: Roberto Castano, Eva Suarthana Tags: Case Report Source Type: research

Significant rise of the prevalence and clinical features of childhood asthma in Qingdao China: cluster sampling investigation of 10,082 children
Conclusions: The prevalence of asthma in children aged 0-14 years in Qingdao China increased significantly based on data obtained ten years ago (2000). Respiratory tract infections were the most important precursors of asthma attack. The attack was most commonly manifested as cough. The treatment, especially the use of ICS, was more rational. However, a certain difference was found, which has yet to be contrasted with the Global Initiative for Asthma (GINA) project. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 26, 2014 Category: Epidemiology Authors: Rongjun LinRenzheng GuanXiaomei LiuBaochun ZhaoJie GuanLing Lu Source Type: research

Aging‐related changes in swallowing, and in the coordination of swallowing and respiration determined by novel non‐invasive measurement techniques
ConclusionsWe used integrated non‐invasive measurements to document age‐related changes in swallowing, and in the coordination of swallowing and respiration in healthy adults. Geriatr Gerontol Int 2014; ●●: ●●–●●. (Source: Geriatrics and Gerontology International)
Source: Geriatrics and Gerontology International - September 26, 2014 Category: Geriatrics Authors: Chin‐Man Wang, Ji‐Yih Chen, Chiung‐Cheng Chuang, Wen‐Chun Tseng, Alice MK Wong, Yu‐Cheng Pei Tags: Original Article: Epidemiology, Clinical Practice And Health Source Type: research

Information¿processing methods for mortality surveillance in the presence of varying levels of completeness and ill¿defined codes of causes of death ¿ the case of Brazil
Conclusions: The approach developed is an additional step toward rapid and accurate reporting of Brazilian NCD mortality data. The code is available and may be adapted by others facing similar tasks. (Source: Population Health Metrics)
Source: Population Health Metrics - September 26, 2014 Category: Epidemiology Authors: Antony StevensMaria SchmidtBruce Duncan Source Type: research

Evaluation of the PaO2/FiO2 ratio after cardiac surgery as a predictor of outcome during hospital stay
Conclusions: A simple determination of PaO2/FIO2 at 3 h after ICU admission may be useful to identify patients at risk immediately after cardiac surgery. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - September 26, 2014 Category: Anesthesiology Authors: Francisco EsteveJuan Lopez-DelgadoCasimiro JavierreKonstantina SkaltsaMaria CarrioDavid Rodríguez-CastroHerminia TorradoElisabet FarreroAntonio Diaz-PrietoJosep VenturaRafael Mañez Source Type: research

Bacillus cihuensis sp. nov., isolated from rhizosphere soil of a plant in the Cihu area of Taiwan.
Abstract A Gram-positive, moderately halotolerant, rod-shaped, spore forming bacterium, designated strain FJAT-14515(T) was isolated from a soil sample in Cihu area, Taoyuan County, Taiwan. The strain grew at 10-35 °C (optimum at 30 °C), pH 5.7-9.0 (optimum at pH 7.0) and at salinities of 0-5 % (w/v) NaCl (optimum at 1 % w/v). The diagnostic diamino acid of the peptidoglycan of the isolated strain was meso-diaminopimelic acid and major respiratory isoprenoid quinone was MK-7. Major cellular fatty acids were anteiso-C15:0 (40.6 %), iso-C15:0 (20.7 %) and the DNA G+C content of strain FJAT-14515(T) was 37.1 ...
Source: Antonie van Leeuwenhoek - September 26, 2014 Category: Microbiology Authors: Liu B, Liu GH, Sengonca C, Schumann P, Wang MK, Tang JY, Chen MC Tags: Antonie Van Leeuwenhoek Source Type: research

Oxidative Stress Regulates CFTR Gene Expression in Human Airway Epithelial Cells Through a Distal Antioxidant Response Element.
Abstract Cystic fibrosis transmembrane conductance regulator gene (CFTR) expression in human airway epithelial cells involves the recruitment of distal cis-regulatory elements, which are associated with airway-selective DNase hypersensitive sites (DHS) at -44kb and -35kb from the gene. The -35kb site encompasses an enhancer that is regulated by the immune mediators Interferon Regulatory Factor 1 and 2 (IRF1/2) and by Nuclear Factor Y (NF-Y). Here we investigate the -44 kb element, which also has enhancer activity in vitro in airway epithelial cells but is inactive in intestinal epithelial cells. This site contains ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 26, 2014 Category: Molecular Biology Authors: Zhang Z, Leir SH, Harris A Tags: Am J Respir Cell Mol Biol Source Type: research