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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Home-Made Continuous Positive Airways Pressure Device may Reduce Mortality in Neonates with Respiratory Distress in Low-Resource Setting
Conclusion: A low-cost and locally assembled CPAP delivery system may reduce neonatal mortality among babies with respiratory distress. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - October 1, 2014 Category: Tropical Medicine Authors: Daga, S., Mhatre, S., Borhade, A., Khan, D. Tags: Original Papers Source Type: research

Is Continuous Positive Airway Pressure a Feasible Treatment Modality for Neonates with Respiratory Distress Syndrome in a Rural District Hospital?
Conclusions: nCPAP for neonatal respiratory distress at the district hospital is feasible, safe and offers the potential for significant cost savings. (Source: Journal of Tropical Pediatrics)
Source: Journal of Tropical Pediatrics - October 1, 2014 Category: Tropical Medicine Authors: Hendriks, H., Kirsten, G. F., Voss, M., Conradie, H. Tags: Original Papers Source Type: research

How Rhinovirus Infections Cause Exacerbations of Asthma
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - October 1, 2014 Category: Allergy & Immunology Authors: James E. Gern Tags: Invited Review Source Type: research

Increased lung inflammation with oxygen supplementation in tracheotomized spontaneously breathing rabbits: an experimental prospective randomized study
Conclusions: Oxygen supplementation in spontaneous breathing is associated with an increased inflammatory response when compared to breathing normal room air. This inflammatory response was mainly constituted with polymorphonuclear cells (eosinophils and neutrophils). As confirmed in all animals by peripheral blood analyses, the eosinophilic inflammatory response was a local organ event. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 1, 2014 Category: Anesthesiology Authors: Humberto MachadoCatarina NunesPaula SáAntonio CouceiroÁlvaro da SilvaArtur Águas Source Type: research

Current ventilation practice during general anaesthesia: a prospective audit in Melbourne, Australia
Conclusion: In mechanically ventilated patients under general anaesthesia, tidal volume was high and PEEP was applied to the majority of patients, but at modest levels. The findings of our study suggest that the control groups of previous randomized controlled trials do not closely reflect the practice of mechanical ventilation in Australia. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 1, 2014 Category: Anesthesiology Authors: Dharshi KaralapillaiLaurence WeinbergJonathan GaltieriNeil GlassfordGlenn EastwoodJai DarvallJake GeertsemaRavi BangiaJane FitzgeraldTuong PhanLuke OHallaranAdriano CoccianteStuart WatsonDavid StoryRinaldo Bellomo Source Type: research

General Health Status and Late Effects Among Adolescent and Young Adult Survivors of Childhood Cancer in Japan
Conclusions Many adolescent/young adult childhood cancer survivors could be suffering from ongoing late effects that stem from cancer and its treatment. Overall health monitoring for childhood cancer survivors can provide indispensable benefits. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - October 1, 2014 Category: Cancer & Oncology Authors: Ozono, S., Ishida, Y., Honda, M., Okamura, J., Asami, K., Maeda, N., Sakamoto, N., Inada, H., Iwai, T., Kamibeppu, K., Kakee, N., Horibe, K. Tags: Original Articles Pediatrics Source Type: research

A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections
Conclusions: The incidence of AC increases with age. Infections, especially bacterial infections, are associated with the incidence of ACs and this increases with age. (Source: BMC Endocrine Disorders)
Source: BMC Endocrine Disorders - October 1, 2014 Category: Endocrinology Authors: Rosemary RushworthDavid Torpy Source Type: research

Ventilation Practices in Subarachnoid Hemorrhage: A Cohort Study Exploring the Use of Lung Protective Ventilation
Conclusion Patients with SAH requiring mechanical ventilation frequently breathe spontaneously, generating tidal volumes above usual protective thresholds regardless of meeting ARDS criteria. In patients with SAH, the presence of an additional ARDS risk factor should prompt close screening for the development of ARDS and consideration of adjustment of ventilator settings to meet lung protective thresholds. (Source: Neurocritical Care)
Source: Neurocritical Care - October 1, 2014 Category: Neurology Source Type: research

Real-time monitoring of endogenous lipid peroxidation by exhaled ethylene in patients undergoing cardiac surgery
Pulmonary and systemic organ injury produced by oxidative stress including lipid peroxidation is a fundamental tenet of ischemia-reperfusion injury, inflammatory response to cardiac surgery, and cardiopulmonary bypass (CPB) but is not routinely measured in a surgically relevant time frame. To initiate a paradigm shift toward noninvasive and real-time monitoring of endogenous lipid peroxidation, we have explored pulmonary excretion and dynamism of exhaled breath ethylene during cardiac surgery to test the hypothesis that surgical technique and ischemia-reperfusion triggers lipid peroxidation. We have employed laser photoaco...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Cristescu, S. M., Kiss, R., te Lintel Hekkert, S., Dalby, M., Harren, F. J. M., Risby, T. H., Marczin, N., on behalf of the Harefield BIOSTRESS study investigators Tags: RAPID REPORTS Source Type: research

The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator
Premature infants requiring supplemental oxygen are at increased risk for developing bronchopulmonary dysplasia (BPD). Rodent models involving neonatal exposure to excessive oxygen concentrations (hyperoxia) have helped to identify mechanisms of BPD-associated pathology. Genome-wide assessments of the effects of hyperoxia in neonatal mouse lungs could identify novel BPD-related genes and pathways. Newborn C57BL/6 mice were exposed to 100% oxygen for 10 days, and whole lung tissue RNA was used for high-throughput, sequencing-based transcriptomic analysis (RNA-Seq). Significance Analysis of Microarrays and Ingenuity Pathway ...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Bhattacharya, S., Zhou, Z., Yee, M., Chu, C.-Y., Lopez, A. M., Lunger, V. A., Solleti, S. K., Resseguie, E., Buczynski, B., Mariani, T. J., O'Reilly, M. A. Tags: CALL FOR PAPERS Source Type: research

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury
Claudins are tight junction proteins that regulate paracellular ion permeability of epithelium and endothelium. Claudin 4 has been reported to function as a paracellular sodium barrier and is one of three major claudins expressed in lung alveolar epithelial cells (AEC). To directly assess the role of claudin 4 in regulation of alveolar epithelial barrier function and fluid homeostasis in vivo, we generated claudin 4 knockout (Cldn4 KO) mice. Unexpectedly, Cldn4 KO mice exhibited normal physiological phenotype although increased permeability to 5-carboxyfluorescein and decreased alveolar fluid clearance were noted. Cldn4 KO...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Kage, H., Flodby, P., Gao, D., Kim, Y. H., Marconett, C. N., DeMaio, L., Kim, K.-J., Crandall, E. D., Borok, Z. Tags: ARTICLES Source Type: research

PKG-1{alpha} leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension
Pulmonary hypertension (PH) is a chronic disease characterized by a progressive increase in vasomotor tone, narrowing of the vasculature with structural remodeling, and increase in pulmonary vascular resistance. Current treatment strategies include nitric oxide therapy and methods to increase cGMP-mediated vasodilatation. cGMP-dependent protein kinases (PKG) are known mediators of nitric oxide- and cGMP-induced vasodilatation. Deletion of PKG-1 in mice has been shown to induce PH, however, the exact mechanisms by which loss of PKG-1 function leads to PH is not known. In a mouse model with a selective mutation in the NH2-te...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Ramchandran, R., Raghavan, A., Geenen, D., Sun, M., Bach, L., Yang, Q., Raj, J. U. Tags: ARTICLES Source Type: research

Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats
Although hypoxia is detrimental to most cell types, it aids survival of progenitor cells and is associated with diseases like cancer and pulmonary hypertension in humans. Therefore, understanding the underlying mechanisms that promote survival of progenitor cells in hypoxia and then developing novel therapies to stop their growth in hypoxia-associated human diseases is important. Here we demonstrate that the proliferation and growth of human CD133+ progenitor cells, which contribute to tumorigenesis and the development of pulmonary hypertension, are increased when cultured under hypoxic conditions. Furthermore, glucose-6-p...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Chettimada, S., Joshi, S. R., Alzoubi, A., Gebb, S. A., McMurtry, I. F., Gupte, R., Gupte, S. A. Tags: ARTICLES Source Type: research

A comparative study of matrix remodeling in chronic models for COPD; mechanistic insights into the role of TNF-{alpha}
Remodeling in chronic obstructive pulmonary disease (COPD) has at least two dimensions: small airway wall thickening and destruction of alveolar walls. Recently we showed comparable alterations of the extracellular matrix (ECM) compounds collagen, hyaluoran, and elastin in alveolar and small airway walls of COPD patients. The aim of this study was to characterize and assess similarities in alveolar and small airway wall matrix remodeling in chronic COPD models. From this comparative characterization of matrix remodeling we derived and elaborated underlying mechanisms to the matrix changes reported in COPD. Lung tissue sect...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Eurlings, I. M. J., Dentener, M. A., Mercken, E. M., de Cabo, R., Bracke, K. R., Vernooy, J. H. J., Wouters, E. F. M., Reynaert, N. L. Tags: ARTICLES Source Type: research

{alpha}-Klotho protects against oxidative damage in pulmonary epithelia
α-Klotho exerts pleiotropic biological actions. Heterozygous α-Klotho haplo-insufficient mice (kl/+) appear normal at baseline except for age-related changes in the lung, suggesting heightened pulmonary susceptibility to α-Klotho deficiency. We used in vivo and in vitro models to test whether α-Klotho protects lung epithelia against injury. Normally, α-Klotho is not expressed in the lung, but circulating α-Klotho levels are reduced ~40% in kl/+ mice and undetectable in homozygous α-Klotho-deficient mice (kl/kl). kl/+ mice show distal air space enlargement at a given airway pressure...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Ravikumar, P., Ye, J., Zhang, J., Pinch, S. N., Hu, M. C., Kuro-o, M., Hsia, C. C. W., Moe, O. W. Tags: ARTICLES Source Type: research

Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation
We previously reported that transglutaminase 2 (TG2) activity is markedly elevated in lungs of hypoxia-exposed rodent models of pulmonary hypertension (PH). Since vascular remodeling of pulmonary artery smooth muscle cells (PASMCs) is important in PH, we undertook the present study to determine whether TG2 activity is altered in PASMCs with exposure to hypoxia and whether that alteration participates in their proliferative response to hypoxia. Cultured distal bovine (b) and proximal human (h) PASMCs were exposed to hypoxia (3% O2) or normoxia (21% O2). mRNA and protein expression were determined by PCR and Western blot ana...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Penumatsa, K. C., Toksoz, D., Warburton, R. R., Hilmer, A. J., Liu, T., Khosla, C., Comhair, S. A. A., Fanburg, B. L. Tags: ARTICLES Source Type: research

Proinflammatory role of neutrophil extracellular traps in abdominal sepsis
Excessive neutrophil activation is a major component in septic lung injury. Neutrophil-derived DNA may form extracellular traps in response to bacterial invasions. The aim of the present study was to investigate the potential role of neutrophil extracellular traps (NETs) in septic lung injury. Male C57BL/6 mice were treated with recombinant human (rh)DNAse (5 mg/kg) after cecal ligation and puncture (CLP). Extracellular DNA was stained by Sytox green, and NET formation was quantified by confocal microscopy and cell-free DNA in plasma, peritoneal cavity, and lung. Blood, peritoneal fluid, and lung tissue were harvested for ...
Source: AJP: Lung Cellular and Molecular Physiology - October 1, 2014 Category: Respiratory Medicine Authors: Luo, L., Zhang, S., Wang, Y., Rahman, M., Syk, I., Zhang, E., Thorlacius, H. Tags: ARTICLES Source Type: research

Methionine restriction slows down senescence in human diploid fibroblasts
Summary Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex IV, but also complex I, which was due to a decreased translation rate of several mtDNA‐encoded subunits. Together, these findings indicate that M...
Source: Aging Cell - October 1, 2014 Category: Cytology Authors: Rafał Kozieł, Christoph Ruckenstuhl, Eva Albertini, Michael Neuhaus, Christine Netzberger, Maria Bust, Frank Madeo, Rudolf J. Wiesner, Pidder Jansen‐Dürr Tags: Original Article Source Type: research

Spirometric Evaluation in Juvenile Idiopathic Arthritis: Data from Eastern India
Conclusion Spirometry in JIA patients demonstrated statistically significant restrictive pattern of alteration in pulmonary function. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 1, 2014 Category: Pediatrics Source Type: research

Use of Multimodal Imaging in the Management of Tumor Embolism From the Inferior Vena Cava Through the Right Heart in a Patient With Renal Cell Carcinoma
R?>ENAL CELL CARCINOMA invades the inferior vena cava in approximately 10% of patients, with further tumor extension into the right atrium occurring in only 1%. Survival after renal cell carcinoma embolization into the pulmonary artery is unusual, but surgical resection of tumor emboli occasionally has been reported. The present report describes the management of large bilateral pulmonary tumor emboli after nephrectomy for renal cell carcinoma. Using transesophageal echocardiography (TEE), the authors directly observed large fragments break off from the patient’s inferior vena caval tumor during the nephrectomy and migra...
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 1, 2014 Category: Anesthesiology Authors: Elizabeth M. Colwell, Sweeta D. Gandhi, Zafar Iqbal, Zahir A. Rashid, Paul S. Pagel Tags: E-CHALLENGES & CLINICAL DECISIONS Source Type: research

October Highlights/Papers by Junior Investigators/NIH News.
Authors: PMID: 25275431 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - October 1, 2014 Category: Molecular Biology Tags: Am J Respir Cell Mol Biol Source Type: research

A rare association between Fabry¿s disease and granulomatosis with polyangiitis: a potential pathogenic link
Conclusion: Because both Fabry’s disease and granulomatosis with polyangiitis or crescentic glomerulonephritis are rare diseases, their concurrence in this and related cases suggests there may be a pathogenic link between these two conditions. Fabry’s disease may be underdiagnosed, particularly in cases of granulomatosis with polyangiitis or crescentic glomerulonephritis. (Source: BMC Nephrology)
Source: BMC Nephrology - October 1, 2014 Category: Urology & Nephrology Authors: Hironari HanaokaAkinori HashiguchiKonosuke KonishiTomohiro IshiiMasataka Kuwana Source Type: research

Dynamic MR urography in children with uropathic disease with a combined 2D and 3D acquisition protocol - Comparison with MAG3 scintigraphy.
Conclusions: The proposed protocol provides a robust technique for assessment of ureteral obstruction and split renal function with compensation of breathing artifacts, short post-processing time, and excellent 3D spatial resolution. Advances in Knowledge: The combined protocol of 2D and 3D MR urography is an efficient technique for assessment of renal morphology and function. PMID: 25270833 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 1, 2014 Category: Radiology Authors: Boss A, Martirosian P, Fuchs J, Obermayr F, Tsiflikas I, Schick F, Schäfer JF Tags: Br J Radiol Source Type: research

Feasibility of automated pancreas segmentation based on dynamic MRI.
Conclusions: We have shown the feasibility of automated segmentation of the pancreas anatomy on dynamic MRI. Advances in knowledge: Using the hybrid method improves segmentation robustness of low-contrast images. PMID: 25270713 [PubMed - as supplied by publisher] (Source: The British Journal of Radiology)
Source: The British Journal of Radiology - October 1, 2014 Category: Radiology Authors: Gou S, Wu J, Liu F, Lee P, Rapacchi S, Hu P, Sheng K Tags: Br J Radiol Source Type: research

Pulmonary artery aneurysms.
PMID: 25271757 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Ataya A, Alnuaimat H Tags: Am J Respir Crit Care Med Source Type: research

Malignant uveitis masquerade syndrome.
PMID: 25271756 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Tan AH, Chee SP Tags: Am J Respir Crit Care Med Source Type: research

Erratum: club cell protein 16 and disease progression in chronic obstructive pulmonary disease.
Authors: PMID: 25271755 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply: Understanding the Roles of the Vitamin E Isoforms α- and γ-Tocopherol in Allergic Airway Disease.
PMID: 25271754 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Cook-Mills J, Hartert T Tags: Am J Respir Crit Care Med Source Type: research

Two faces of vitamin e in the lung.
PMID: 25271753 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: G Wagner J, R Harkema J, Jiang Q, Hernandez M, B Peden D Tags: Am J Respir Crit Care Med Source Type: research

Reply: primary and secondary prevention of chronic obstructive pulmonary disease: where to next?
PMID: 25271752 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Kiley JP, Gibbons GH Tags: Am J Respir Crit Care Med Source Type: research

Primary and secondary prevention of chronic obstructive pulmonary disease: where to next?
PMID: 25271751 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Young RP, J Hopkins R Tags: Am J Respir Crit Care Med Source Type: research

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery.
PMID: 25271750 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Ahn B, Beaver T, Martin T, Hess P, Brumback BA, Ahmed S, Smith BK, Leeuwenburgh C, Martin AD, Ferreira LF Tags: Am J Respir Crit Care Med Source Type: research

Inoculation of QuantiFERON-TB Tubes with Skin Microbiota Causes False-Positive Results.
PMID: 25271749 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Gaur RL, Banaei N Tags: Am J Respir Crit Care Med Source Type: research

The Allocation of Intensivists' Rounding Time under Conditions of Intensive Care Unit Capacity Strain.
PMID: 25271748 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Brown SE, Rey MM, Pardo D, Weinreb S, Ratcliffe SJ, Gabler NB, Halpern SD Tags: Am J Respir Crit Care Med Source Type: research

Disseminated tuberculosis with splenic tuberculosis abscess rupture. A rare presentation.
PMID: 25271747 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Tang T, Hsu Y, Lee JJ Tags: Am J Respir Crit Care Med Source Type: research

Protocol-based Treatment of Septic Shock, Fibrinolysis for Submassive Pulmonary Embolism, and Use of Corticosteroids in Acute Exacerbations of Chronic Obstructive Pulmonary Disease Requiring Mechanical Ventilation.
PMID: 25271746 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Sharma N, Venado A, Morrison J Tags: Am J Respir Crit Care Med Source Type: research

An official american thoracic society/american association of critical-care nurses/american college of chest physicians/society of critical care medicine policy statement: the choosing wisely® top 5 list in critical care medicine.
CONCLUSIONS: These five recommendations provide a starting point for clinicians and patients to make decisions leading to higher-quality, lower-cost care. Future work is needed to promote adherence to these recommendations and to develop additional ways for intensive care clinicians to take leadership in reining in health-care costs. PMID: 25271745 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 1, 2014 Category: Respiratory Medicine Authors: Halpern SD, Becker D, Curtis JR, Fowler R, Hyzy R, Kaplan LJ, Rawat N, Sessler CN, Wunsch H, Kahn JM, Choosing Wisely Taskforce Tags: Am J Respir Crit Care Med Source Type: research