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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Coverage of and factors associated with pneumococcal vaccination in chronic obstructive pulmonary disease
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - May 3, 2015 Category: Respiratory Medicine Authors: Carreño-Ibáñez, L. V.Esteban-Vasallo, M. D.Domínguez-Berjón, M. F.Astray-Mochales, J.González del Yerro, C.Iniesta-Fornies, D.Gascón-Sancho, M. J.Jiménez-García, R. Tags: ORIGINAL ARTICLES Source Type: research

Incidence of idiopathic pulmonary fibrosis in Korea based on the 2011 ATS/ERS/JRS/ALAT statement
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - May 3, 2015 Category: Respiratory Medicine Authors: Gjonbrataj, J.Choi, W-I.Bahn, Y. E.Rho, B. H.Lee, J. J.Lee, C. W. Tags: ORIGINAL ARTICLES Source Type: research

Percutaneous treatment for pulmonary hypertension caused by pulmonary artery stenosis due to anthracosis
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - May 3, 2015 Category: Respiratory Medicine Authors: Ahn, Jee HwanAhn, Jung-MinLee, Seung-WhanChoi, Se HoonOh, Sang YoungLee, Sang MinLee, Sang-DoLee, Jae Seung Tags: CORRESPONDENCE Source Type: research

The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae.
Abstract Escherichia coli sequence type 131 (ST131) and Klebsiella pneumoniae ST258 emerged in the 2000s as important human pathogens, have spread extensively throughout the world, and are responsible for the rapid increase in antimicrobial resistance among E. coli and K. pneumoniae strains, respectively. E. coli ST131 causes extraintestinal infections and is often fluoroquinolone resistant and associated with extended-spectrum β-lactamase production, especially CTX-M-15. K. pneumoniae ST258 causes urinary and respiratory tract infections and is associated with carbapenemases, most often KPC-2 and KPC-3. The most ...
Source: Clinical Microbiology Reviews - May 3, 2015 Category: Microbiology Authors: Mathers AJ, Peirano G, Pitout JD Tags: Clin Microbiol Rev Source Type: research

Normalization of lung function following treatment of secondary usual interstitial pneumonia: a case report.
This report suggests that occasionally, patients with secondary UIP occurring in the context of otherwise undefinable autoimmune clinical syndromes may be responsive to immunosuppressive therapy. PMID: 25922588 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - May 3, 2015 Category: Respiratory Medicine Authors: Hohberger LA, Montero-Arias F, Roden AC, Vassallo R Tags: Clin Med Insights Circ Respir Pulm Med Source Type: research

Serological assessment of neutrophil elastase activity on elastin during lung ECM remodeling
Background: During the pathological destruction of lung tissue, neutrophil elastase (NE) degrades elastin, one of the major constituents of lung parenchyma. However there are no non-invasive methods to quantify NE degradation of elastin. We selected specific elastin fragments generated by NE for antibody generation and developed an ELISA assay (EL-NE) for the quantification of NE-degraded elastin. Methods: Monoclonal antibodies were developed against 10 NE-specific cleavage sites on elastin. One EL-NE assay was tested for analyte stability, linearity and intra- and inter-assay variation. The NE specificity was demonstrated...
Source: BMC Pulmonary Medicine - May 3, 2015 Category: Respiratory Medicine Authors: Jacob KristensenMorten KarsdalJannie SandNicholas WillumsenClaudia DiefenbachBirte SvenssonPer HägglundDiana Oersnes-Leeming Source Type: research

Crystallization and preliminary X-ray crystallographic study of a 3.8-MDa respiratory supermolecule hemocyanin
Publication date: Available online 2 May 2015 Source:Journal of Structural Biology Author(s): Asuka Matsuno , Zuoqi Gai , Miyuki Tanaka , Koji Kato , Sanae Kato , Tsuyoshi Katoh , Takeshi Shimizu , Takeya Yoshioka , Hideki Kishimura , Yoshikazu Tanaka , Min Yao Many molluscs transport oxygen using a very large cylindrical multimeric copper-containing protein named hemocyanin. The molluscan hemocyanin forms a decamer (cephalopods) or multidecamer (gastropods) of approximately 330–450kDa subunits, resulting in a molecular mass >3.3MDa. Therefore, molluscan hemocyanin is one of the largest proteins. The reason why ...
Source: Journal of Structural Biology - May 3, 2015 Category: Biology Source Type: research

Anti-inflammatory effects of water extract of Taraxacum mongolicum hand.-Mazz on lipopolysaccharide-induced inflammation in acute lung injury by suppressing PI3K/Akt/mTOR signaling pathway
Conclusion The results indicated that the WETMHM had a protective effect on LPS-induced ALI in mice. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - May 3, 2015 Category: Drugs & Pharmacology Source Type: research

Role of interleukin-6 (IL-6) in diagnosis of malignant pleural mesothelioma
Conclusion Pleural fluid level of interleukin-6 can be used as diagnostic tool for malignant pleural mesothelioma (MPM). Pleural fluid level of interleukin-6 (IL-6) can be used in differentiating malignant from non malignant effusions, pleural effusions secondary to malignant pleural mesothelioma (MPM) from those secondary to Adenocarcinoma. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - May 3, 2015 Category: Respiratory Medicine Source Type: research

Transitioning from ‘stopping' to ‘ending' the tuberculosis epidemic
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - May 3, 2015 Category: Respiratory Medicine Authors: Getahun, HaileyesusVarma, Jay Tags: EDITORIALS Source Type: research

Erratum to Childhood asthma in 2015: The Fuss and the Future
It was discovered that the original online version of the above article containing errors that were not the fault of the author. The Publisher decided to ‘resupply’ (repost and replace) the XML and online PDF of the article. Unfortunately the discovery of the error was too late to correct the print issue. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - May 3, 2015 Category: Respiratory Medicine Authors: Dominic A. Fitzgerald Tags: Erratum Source Type: research

Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV/VC
The authors report no conflicts of interest. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 3, 2015 Category: Respiratory Medicine Authors: Carlos A. Vaz Fragoso, Jeffrey J. Pretto, Philip H. Quanjer Tags: Letter to the Editor Source Type: research

Exposure to air pollution and meteorological factors associated with children's primary care visits at night due to asthma attack: case-crossover design for 3-year pooled patients
Conclusions The findings in the present study supported an association between ozone and PCVs and suggest that certain meteorological items may be associated with PCVs. (Source: BMJ Open)
Source: BMJ Open - May 3, 2015 Category: Journals (General) Authors: Yamazaki, S., Shima, M., Yoda, Y., Oka, K., Kurosaka, F., Shimizu, S., Takahashi, H., Nakatani, Y., Nishikawa, J., Fujiwara, K., Mizumori, Y., Mogami, A., Yamada, T., Yamamoto, N. Tags: Open access, Epidemiology, Occupational and environmental medicine, Public health, Respiratory medicine Research Source Type: research

Implementation of a Model of Bodily Fluids Regulation.
Abstract The classic model of blood pressure regulation by Guyton et al. (Annu Rev Physiol 34:13-46, 1972a; Ann Biomed Eng 1:254-281, 1972b) set a new standard for quantitative exploration of physiological function and led to important new insights, some of which still remain the focus of debate, such as whether the kidney plays the primary role in the genesis of hypertension (Montani et al. in Exp Physiol 24:41-54, 2009a; Exp Physiol 94:382-388, 2009b; Osborn et al. in Exp Physiol 94:389-396, 2009a; Exp Physiol 94:388-389, 2009b). Key to the success of this model was the fact that the authors made the computer cod...
Source: Acta Biotheoretica - May 3, 2015 Category: Biomedical Science Authors: Fontecave-Jallon J, Thomas SR Tags: Acta Biotheor Source Type: research

Multistage three-dimensional UTE lung imaging by image-based self-gating.
CONCLUSION: Image-based respiratory self gating in UTE 3D lung images allows successful retrospective respiratory gating, also enabling reconstruction of intermediate respiratory stages. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. PMID: 25940111 [PubMed - as supplied by publisher] (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - May 3, 2015 Category: Radiology Authors: Tibiletti M, Paul J, Bianchi A, Wundrak S, Rottbauer W, Stiller D, Rasche V Tags: Magn Reson Med Source Type: research

Comment on: Wollmer P, Engström G. Fixed ratio or lower limit of normal (LLN) as cut-off value for FEV/VC: An outcome study. Respiratory Medicine (2013) 107, 1460–1462.
In a recent article [1], Wollmer and Engström concluded that “FEV1/VC  (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 3, 2015 Category: Respiratory Medicine Authors: Carlos A. Vaz Fragoso, Jeffrey J. Pretto, Philip H. Quanjer Tags: Letter to the Editor Source Type: research

Cost and outcomes of assessing patients with chest pain in an Australian emergency department.
CONCLUSIONS: Most ED patients with symptoms of possible ACS do not have a cardiac cause for their presentation. The current guideline-based process of assessment is lengthy, costly and consumes significant resources. Investigation of strategies to shorten this process or reduce the need for objective cardiac testing in patients at intermediate risk according to the National Heart Foundation and Cardiac Society of Australia and New Zealand guideline is required. PMID: 25929506 [PubMed - in process] (Source: Med J Aust)
Source: Med J Aust - May 2, 2015 Category: Journals (General) Authors: Cullen L, Greenslade J, Merollini K, Graves N, Hammett CJ, Hawkins T, Than MP, Brown AF, Huang CB, Panahi SE, Dalton E, Parsonage WA Tags: Med J Aust Source Type: research

Probiotics for preventing acute upper respiratory tract infections.
CONCLUSIONS: Probiotics were better than placebo in reducing the number of participants experiencing episodes of acute URTI, the mean duration of an episode of acute URTI, antibiotic use and cold-related school absence. This indicates that probiotics may be more beneficial than placebo for preventing acute URTIs. However, the quality of the evidence was low or very low. PMID: 25927096 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2015 Category: Journals (General) Authors: Hao Q, Dong BR, Wu T Tags: Cochrane Database Syst Rev Source Type: research

Inositol in preterm infants at risk for or having respiratory distress syndrome.
CONCLUSIONS: Inositol supplementation results in statistically significant and clinically important reductions in important short-term adverse neonatal outcomes. A large size multi-centre randomised controlled trial is currently ongoing and the trial will likely confirm or refute the findings from this systematic review. PMID: 25927089 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2015 Category: Journals (General) Authors: Howlett A, Ohlsson A, Plakkal N Tags: Cochrane Database Syst Rev Source Type: research

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture.
CONCLUSIONS: Based upon moderate quality evidence, our review does not support a role for vertebroplasty for treating osteoporotic vertebral fractures in routine practice. We found no demonstrable clinically important benefits compared with a sham procedure and subgroup analyses indicated that results did not differ according to duration of pain ≤ 6 weeks versus > 6 weeks. Sensitivity analyses confirmed that open trials comparing vertebroplasty with usual care are likely to have overestimated any benefit of vertebroplasty. Correcting for these biases would likely drive any benefits observed with vertebroplasty towards...
Source: Cochrane Database of Systematic Reviews - May 2, 2015 Category: Journals (General) Authors: Buchbinder R, Golmohammadi K, Johnston RV, Owen RJ, Homik J, Jones A, Dhillon SS, Kallmes DF, Lambert RG Tags: Cochrane Database Syst Rev Source Type: research

Acupuncture for mumps in children.
CONCLUSIONS: We could not reach any conclusion about the efficacy and safety of acupuncture as we identified no trials for inclusion in this review. More high-quality research is needed. PMID: 25922859 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - May 2, 2015 Category: Journals (General) Authors: He J, Jia P, Zheng M, Zhang M, Jiang H Tags: Cochrane Database Syst Rev Source Type: research

Aspirin-exacerbated respiratory disease: characteristics and management strategies
Expert Review of Clinical Immunology, Ahead of Print. (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 2, 2015 Category: Allergy & Immunology Tags: article Source Type: research

Factors impacting the growth and nutritional status of cystic fibrosis patients younger than 10 years of age who did not undergo neonatal screening
CONCLUSIONS: Greater number of hospitalizations, diagnosis delay and early onset of respiratory disease had a negative impact on growth. Lower spirometric values, lower gestational age, lower birth weight, and early onset of respiratory symptoms had negative impact on nutritional status. Malnutrition was observed in 7.7% of cases, but 23% of children had nutritional risk. OBJETIVO: Avaliar por meio de parâmetros clínicos e laboratoriais como a fibrose cística (FC) afeta o crescimento e estado nutricional de crianças submetidas ao tratamento de FC que não foram submetidas à triagem neonatal. MÉTODOS: Uma coorte hist...
Source: Revista Paulista de Pediatria - May 2, 2015 Category: Pediatrics Source Type: research

Dysfunctional BLK in common variable immunodeficiency perturbs B-cell proliferation and ability to elicit antigen-specific CD4+ T-cell help.
In conclusion, we found a novel BLK gene variant in CVID-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4+ T-cell responses. Both these mechanisms may contribute to hypogammaglobulinemia in CVID-patients. PMID: 25926555 [PubMed - as supplied by publisher] (Source: Oncotarget)
Source: Oncotarget - May 2, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Prevalence and impact of Streptococcus pneumoniae in adult cystic fibrosis patients: a retrospective chart review and capsular serotyping study
Conclusion: Within our center, incident Pneumococcus infection is neither common, associated with a disproportionate clinical deterioration nor results in chronic infection. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 2, 2015 Category: Respiratory Medicine Authors: Christina ThorntonErin BrownJoenel AlcantaraHarvey RabinMichael Parkins Source Type: research

Predictors of microbial agents in dust and respiratory health in the Ecrhs
Conclusion: Indoor dampness was associated with microbial levels in mattress dust which in turn was positively associated with asthma symptoms. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 2, 2015 Category: Respiratory Medicine Authors: Christina TischerJan-Paul ZockMaria ValkonenGert DoekesStefano GuerraDick HeederikDeborah JarvisDan NorbäckMario OlivieriJordi SunyerCecilie SvanesMartin TäubelElisabeth ThieringGiuseppe VerlatoAnne HyvärinenJoachim Heinrich Source Type: research

Constitutive expression of Campylobacter jejuni truncated hemoglobin CtrHb improves the growth of Escherichia coli cell under aerobic and anaerobic conditions
Publication date: Available online 1 May 2015 Source:Enzyme and Microbial Technology Author(s): Jiang-Ke Yang , Wei Xiong , Li Xu , Jia Li , Xiu-Ju Zhao Bacteria hemoglobin could bind to the oxygen, transfer it from the intracellular microenvironment to the respiration process and sustain the energy for the metabolism and reproduction of cells. Heterologous expression of bacteria hemoglobin gene could improve the capacity of the host on oxygen-capturing and allow it to grow even under microaerophilic condition. To develop a system based on hemoglobin to help bacteria cells overcome the oxygen shortage in fermentation, in...
Source: Enzyme and Microbial Technology - May 2, 2015 Category: Biotechnology Source Type: research

In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
Publication date: Available online 30 April 2015 Source:Veterinary Microbiology Author(s): Puck B. van Kasteren , Robert C.M. Knaap , Paul van den Elzen , Eric J. Snijder , Udeni B.R. Balasuriya , Erwin van den Born , Marjolein Kikkert Arteriviruses are a family of positive-stranded RNA viruses that includes the prototypic equine arteritis virus (EAV) and porcine reproductive and respiratory syndrome virus (PRRSV). Although several vaccines against these viruses are commercially available there is room for improvement, especially in the case of PRRSV. The ability of arteriviruses to counteract the immune response is thou...
Source: Veterinary Microbiology - May 2, 2015 Category: Veterinary Research Source Type: research

A double blind randomized placebo control crossover trial on the effect of dietary nitrate supplementation on exercise tolerance in stable moderate chronic obstructive pulmonary disease
Conclusions: Our study does not support a role for routine dietary nitrate supplementation for enhancement of exercise endurance in COPD.Trial registrationAustralia and New Zealand Clinical Trial Register: ACTRN12611001088932 (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 2, 2015 Category: Respiratory Medicine Authors: Paul LeongJane BashamTheresa YongAdrian ChazanPaul FinlaySara BarnesPhillip BardinDonald Campbell Source Type: research

Effectiveness of Montelukast on asthma control in infants: methodology of a French claims data study
Conclusion: These data support the feasibility of the final project, to be conducted on claims data from the whole French population. We also showed that, with appropriate methodology and by using valid criteria, French claims data are an adequate resource for conducting comparative effectiveness studies in pediatric asthma. Finally, the algorithm used to identify infants with asthma could be applied to other studies using claims data. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 2, 2015 Category: Respiratory Medicine Authors: Manon BelhassenGérard de PouvourvilleLaurent LaforestJacques BrouardJacques de BlicBrigitte FaurouxValérie LaigleCéline Chanut-VogelLiliane LamezecEric Van Ganse Source Type: research

Oxidative stress and nitric oxide signaling related biomarkers in patients with pulmonary hypertension: a case control study
Background: Oxidative stress (OS) and reduced nitric oxide (NO) bioavailability contribute to the pathogenesis of pulmonary hypertension (PH). Whether there are associations between OS and NO signaling biomarkers and whether these biomarkers are associated with the severity of PH remain unclear. Methods: Blood samples were collected from 35 healthy controls and 35 patients with pulmonary arterial hypertension (PAH, n = 12) or chronic thromboembolic pulmonary hypertension (CTEPH, n = 23). The mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance index (PVRI) were measured by right heart catheteriza...
Source: BMC Pulmonary Medicine - May 2, 2015 Category: Respiratory Medicine Authors: Shuai ZhangTing YangXiaomao XuMeng WangLinye ZhongYuanhua YangZhenguo ZhaiFei XiaoChen Wang Source Type: research

Extraordinary benefits of an ordinary silicone tube
Publication date: May 2015 Source:Respiratory Investigation, Volume 53, Issue 3 Author(s): Yoshiki Ishii (Source: Respiratory Investigation)
Source: Respiratory Investigation - May 2, 2015 Category: Respiratory Medicine Source Type: research

Interpolated average CT for cardiac PET/CT attenuation correction
Conclusions IACT-AC reduced respiratory artifacts and improved PET/CT matching similarly to ACT-AC. It is a promising low-dose alternate of ACT for cardiac PET/CT. (Source: Journal of Nuclear Cardiology)
Source: Journal of Nuclear Cardiology - May 2, 2015 Category: Nuclear Medicine Source Type: research

A functionally critical single nucleotide polymorphism in the gene encoding the membrane-bound alcohol dehydrogenase found in ethanol oxidation-deficient Gluconobacter thailandicus.
Abstract The Gluconobacter thailandicus strains NBRC3254, NBRC3255, NBRC3256, NBRC3257, and NBRC3258 are naturally deficient in the ethanol-oxidizing respiratory chain because they do not produce the cytochrome subunit of the membrane-bound alcohol dehydrogenase (ADH). Draft genomes of G. thailandicus strains NBRC3255 and NBRC3257 indicated that the adhB gene encoding the cytochrome subunit contains four base differences when compared to a closely related gene in the public database One of the nucleotide differences results in an Opal codon at the -19th tryptophan (Trp) in the signal sequence for translocation to t...
Source: Gene - May 2, 2015 Category: Genetics & Stem Cells Authors: Charoenyingcharoen P, Matsutani M, Yakushi T, Theeragool G, Yukphan P, Matsushita K Tags: Gene Source Type: research

Effect of fipronil on energy metabolism in the perfused rat liver.
Abstract Fipronil is an insecticide used to control pests in animals and plants that can causes hepatotoxicity in animals and humans, and it is hepatically metabolized to fipronil sulfone by cytochrome P-450. The present study aimed to characterize the effects of fipronil (10 to 50μM) on energy metabolism in isolated perfused rat livers. In fed animals, there was increased glucose and lactate release from glycogen catabolism, indicating the stimulation of glycogenolysis and glycolysis. In the livers of fasted animals, fipronil inhibited glucose and urea production from exogenous L-alanine, whereas ammonia and lact...
Source: Toxicology Letters - May 2, 2015 Category: Toxicology Authors: Medeiros HC, Constantin J, Ishii-Iwamoto EL, Mingatto FE Tags: Toxicol Lett Source Type: research

Characterization and utility of phages bearing peptides with affinity to porcine reproductive and respiratory syndrome virus nsp7 protein.
Abstract High-affinity peptides to porcine reproductive and respiratory syndrome virus (PRRSV) nonstructural protein (nsp) 7 were identified using phage-display technology. Five 12-amino-acid peptide sequences were identified after six rounds of biopanning. A putative CD##WC motif was found in two different consensus peptides borne by phages 4 and 5. The peptides borne by phages 4, 5, and 6 were synthesized for subsequent experiments, according to the results of the binding assays. Immunofluorescence assay revealed that all these peptides recognized nsp7 in PRRSV-infected cells. Furthermore, the peptides demonstrat...
Source: Journal of Virological Methods - May 2, 2015 Category: Virology Authors: Wang H, Liu R, Cui J, Deng S, Xie J, Ning Z, Zhang G Tags: J Virol Methods Source Type: research

[Correspondence] Risk factors for and origins of COPD
Dirkje Postma and colleagues (March 7, p 899)1 provide a very informative overview of the origins of chronic obstructive pulmonary disease (COPD), emphasising the importance of early life respiratory insults and repetitive exposures, such as tobacco smoking and air pollution, later in life. However they do not mention the contribution of pulmonary tuberculosis, which last year alone newly affected nine million people, most of whom were adolescents and young adults.2 (Source: LANCET)
Source: LANCET - May 1, 2015 Category: Journals (General) Authors: Anthony L Byrne, Ben J Marais, Carole D Mitnick, Leonid Lecca, Guy B Marks Tags: Correspondence Source Type: research

[Comment] Respiratory medicine and critical care: a call for papers
The Lancet and The Lancet Respiratory Medicine would like to hear from authors of research papers in any area of clinical research related to respiratory medicine and critical care as the two journals are once again planning special issues timed to coincide with the 2015 European Respiratory Society conference, in Amsterdam, Netherlands, on Sept 26–30. We welcome high-quality submissions from this thriving research community, particularly clinical trials and research that will change clinical practice or current thinking. (Source: LANCET)
Source: LANCET - May 1, 2015 Category: Journals (General) Authors: Emma Grainger, Sabine Kleinert Tags: Comment Source Type: research

[Editorial] Towards better management of COPD
Chronic obstructive pulmonary disease (COPD) is a heterogeneous syndrome that can result from several respiratory conditions, including emphysema, chronic bronchitis, and asthma, and is recognised as one of the world's major public health crises. According to WHO, COPD is the third leading cause of death worldwide. In advance of this year's American Thoracic Society (ATS) conference in Denver, CO, USA (May 15–20), the ATS and the European Respiratory Society released a joint summary of the present and future state of COPD research. (Source: LANCET)
Source: LANCET - May 1, 2015 Category: Journals (General) Authors: The Lancet Tags: Editorial Source Type: research

Patient-controlled intravenous analgesia remifentanil for labor analgesia: time to stop, think and reconsider
Purpose of review: Remifentanil is a relatively new but commonly used opioid alternative in the management of labor pain relief. The present article evaluates efficacy and safety of patient-controlled intravenous analgesia (PCIA) with remifentanil in the management of labor pain relief. Recent findings: Remifentanil PCIA provides analgesia that is superior to nitrous oxide or other opioids such as meperidine, but is less effective when compared with epidural analgesia. Recent evidence suggests it produces significant respiratory depression making routine use as first line analgesia strategy virtually impossible. Summary: R...
Source: Current Opinion in Anaesthesiology - May 1, 2015 Category: Anesthesiology Tags: OBSTETRIC AND GYNECOLOGICAL ANESTHESIA: Edited by Marc Van de Velde Source Type: research

Long-Term, Open-Label, Safety Study of Edivoxetine 12 to 18 mg Once Daily as Adjunctive Treatment for Patients With Major Depressive Disorder Who Are Partial Responders to Selective Serotonin Reuptake Inhibitor Treatment
Abstract: Long-term safety, tolerability, and efficacy of adjunctive edivoxetine hydrochloride (hereafter edivoxetine), a highly selective and potent norepinephrine reuptake inhibitor, was assessed in patients with major depressive disorder (MDD) experiencing partial response to selective serotonin reuptake inhibitor treatment. Data are from a multicenter, 54-week, open-label trial of adjunctive edivoxetine 12 to 18 mg once daily in patients with MDD who had experienced partial response by history to 6 or more weeks of current selective serotonin reuptake inhibitor therapy and who had a 17-item GRID Hamilton Rating Scale f...
Source: Journal of Clinical Psychopharmacology - May 1, 2015 Category: Psychiatry Tags: Original Contributions Source Type: research

Unique among ciliopathies: primary ciliary dyskinesia, a motile cilia disorder.
Authors: Praveen K, Davis EE, Katsanis N Abstract Primary ciliary dyskinesia (PCD) is a ciliopathy, but represents the sole entity from this class of disorders that results from the dysfunction of motile cilia. Characterized by respiratory problems appearing in childhood, infertility, and situs defects in ~50% of individuals, PCD has an estimated prevalence of approximately 1 in 10,000 live births. The diagnosis of PCD can be prolonged due to a lack of disease awareness, coupled with the fact that symptoms can be confused with other more common genetic disorders, such as cystic fibrosis, or environmental insults th...
Source: F1000 Medicine Reports - May 1, 2015 Category: Biomedical Science Tags: F1000Prime Rep Source Type: research