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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

The Ventriculophasic Response: Relationship to Sinus Arrhythmia and the Duration of Interposed QRS Complexes
ConclusionVR, like SA, increases with deep breathing and likely reflects intact parasympathetic nervous system function. Its increase in the presence of narrower beats suggests it may reflect ventricular synchrony.
Source: Annals of Noninvasive Electrocardiology - January 20, 2013 Category: Cardiology Authors: Razvan T. Dadu, Craig A. McPherson Tags: Original Article Source Type: research

“What’s wrong with Mr. Wilson?”
It is a sunny January afternoon at the ER when you are called to see a 57 year old male complaining of feeling "really sick". You find your patient lying in the bed in room 3. He looks pale and short of breath. You introduce yourself and ask him why he has come in today. He says: "About two weeks ago, I started feeling short of breath, with a cough. I got much more tired than usual. I went to see my doctor, who said I had an upper respiratory infection and prescribed me some antibiotics. I rested at home for a few days, and started to feel a little better. Then, I began to go downhill again. Felt so a...
Source: EMS 12-Lead - January 19, 2013 Category: Cardiology Authors: David Baumrind Tags: ems-health-safety ems-topics patient-management Training training-development 12-Lead ECG case study David Baumrind ems12lead.com Paramedic respiratory distress Source Type: research

The Relationship Between Trees and Human Health: Evidence from the Spread of the Emerald Ash Borer
Conclusions: Results suggest that loss of trees to the emerald ash borer increased mortality related to cardiovascular and lower-respiratory-tract illness. This finding adds to the growing evidence that the natural environment provides major public health benefits.
Source: American Journal of Preventive Medicine - January 19, 2013 Category: Global & Universal Authors: Geoffrey H. Donovan, David T. Butry, Yvonne L. Michael, Jeffrey P. Prestemon, Andrew M. Liebhold, Demetrios Gatziolis, Megan Y. Mao Tags: Research Articles Source Type: research

Vaccination of feedlot cattle with extracts and membrane fractions from two Mycoplasma bovis isolates results in strong humoral immune responses but does not protect against an experimental challenge.
Abstract Mycoplasma bovis is one of the most significant contributors to the bovine respiratory syndrome (BRD) that causes major losses in feedlot and dairy farms. Current experimental vaccines against M. bovis are ineffective and in some cases seem to enhance disease. Experimental infection with M. bovis induces a predominantly Th2 response and high levels of IgG1, which is an inferior opsonin and hence lacks protective capacity. In an attempt to induce a balanced (Th1/Th2) immune response, we have used CpG ODN 2007 as an adjuvant in a trial involving vaccination of cattle with M. bovis total extracts and/or membr...
Source: Vaccine - January 19, 2013 Category: Allergy & Immunology Authors: Mulongo M, Prysliak T, Perez-Casal J Tags: Vaccine Source Type: research

Diaphragm morphology of Guinea pig (Cavia porcellus)
ABSTRACT The diaphragm is the main respiratory muscle. Along with other respiratory muscles, the diaphragm is responsible for the muscular contraction that generates the respiratory cycle and, as a consequence, the gaseous interchanges in the lungs. Guinea pigs (Cavia porcellus Linnaeus 1758) are largely used as experimental animals in many biology applications due to their easy management, low cost, and docile behavior. As the diaphragm exerts important effects on lung physiology and function, this study aimed at investigating the morphological characteristics of the muscle, through macroscopic, microscopic, and scanning ...
Source: Microscopy Research and Technique - January 19, 2013 Category: Laboratory Medicine Authors: Thais Borges Lessa, Erika T. Fonseca, Dilayla Kelly Abreu, Marcio Nogueira Rodrigues, Bruno Machado Bertassoli, Fernanda Menezes Oliveira e Silva, Carlos Eduardo Ambrósio Tags: Research Article Source Type: research

A comparison of cardiopulmonary and anesthetic effects of an induction dose of alfaxalone or propofol in dogs
Conclusions and clinical relevanceThere were no clinically significant differences in cardiopulmonary effects between propofol and alfaxalone. A single bolus of propofol resulted in shorter recovery times and fewer adverse events than a single bolus of alfaxalone.
Source: Veterinary Anaesthesia and Analgesia - January 19, 2013 Category: Veterinary Research Authors: Jill K Maney, Molly K Shepard, Christina Braun, Jeannette Cremer, Erik H Hofmeister Tags: Research Paper Source Type: research

Temperature and cardiovascular and respiratory mortality in desert climate. A case study of Kerman, Iran
In this study the relation between temperature and mortality has been studied in a city with desert climate. Four years data on daily temperature, cardiovascular, respiratory mortality and air pollution was acquired for Kerman, Iran. Time series, regression and correlation analyses were performed. Results showed an inverse relationship between mortality and temperature in Kerman, in which decreases in temperature were associated with increases in mortality. This pattern is similar to some foreign studies which show acclimatization of people living in southern warmer climates and less negative effects of warm temperatures. ...
Source: BioMed Central - January 19, 2013 Category: Journals (General) Authors: Narges KhanjaniAbbas Bahrampour Source Type: research

Quadriplegia in a child following adenotonsillectomy
We report the case of a child who, following adentonsillectomy, developed quadriplegia and acute respiratory distress due to previously undetected atlanto‐axial instability. Patients with atlanto‐axial instability often have mild or non‐specific symptoms, despite severe cervical cord compression. Subtle manifestations may be ignored or attributed to other disease processes, which render patients with undiagnosed atlanto‐axial instability at risk of serious neurological injury during general anaesthesia, particularly at the time of laryngoscopy and tracheal intubation.
Source: Anaesthesia - January 18, 2013 Category: Anesthesiology Authors: J. Agarwal, M. S. Tandon, D. Singh, P. Ganjoo Tags: Case Report Source Type: research

Clinical significance of Pneumocystis jiroveci in patients with active tuberculosis
Abstract: Pneumocystis colonization has been associated with airway inflammation and obstruction. We conducted a retrospective cohort study to investigate the clinical significance of Pneumocystis in the airway of patients with active tuberculosis. Of the 108 respiratory specimens tested positive for M. tuberculosis by polymerase chain reaction (PCR), 11 (10.2%) were also positive for Pneumocystis by PCR. Compared with patients tested negative for Pneumocystis, those with Pneumocystis had a higher serum alanine transaminase level, a greater likelihood of requiring oxygen supplementation, and a worse 30-day mortality. The p...
Source: Diagnostic Microbiology and Infectious Disease - January 18, 2013 Category: Microbiology Authors: Kelvin K.W. To, Ivan F.N. Hung, Ting Xu, Rosana W.S. Poon, Whitney C.T. Ip, Patrick T.W. Li, Clara P.Y. Li, Susanna K.P. Lau, Wing-Cheong Yam, Kwok-Hung Chan, Kwok-Yung Yuen Tags: Bacteriology Source Type: research

Relationships between age of puberty onset and height at age 18 years in girls and boys.
CONCLUSIONS: Given that boys and girls may have opposing associations between pubertal timing and adult height and that height is an important predictor of lung function, the effect of pubertal timing on respiratory health should be explored. PMID: 23335183 [PubMed - as supplied by publisher]
Source: World Journal of Pediatrics : WJP - January 18, 2013 Category: Pediatrics Authors: Yousefi M, Karmaus W, Zhang H, Roberts G, Matthews S, Clayton B, Arshad SH Tags: World J Pediatr Source Type: research

Role of dorsolateral periaqueductal grey in the coordinated regulation of cardiovascular and respiratory function.
Abstract The midbrain periaqueductal grey (PAG) contains four longitudinal columns, referred to as the dorsomedial (dmPAG), dorsolateral (dlPAG), lateral (lPAG) and ventrolateral (vlPAG) subdivisions, which collectively have a pivotal role in integrating behavioural and physiological responses to external stressors as well as other functions. This review is focussed on the dlPAG, which is believed to be an important component of the central mechanisms that generate the defensive response to acute psychological stressors, such as the presence of a predator or other immediate threat. The anatomical connections of the...
Source: Autonomic Neuroscience - January 18, 2013 Category: Neuroscience Authors: Dampney RA, Furlong TM, Horiuchi J, Iigaya K Tags: Auton Neurosci Source Type: research

p62 SQSTM1 /LC3b Complex Confers Cytoprotection on Lung Epithelial Cells After Hyperoxia.
In this study, we explored the role of p62 in mitochondria mediated cell death after hyperoxia. Lung alveolar epithelial cells have abundant p62 expression and the p62 level is up-regulated by oxidative stress at both protein and mRNA level. p62 / LC3b complex interacts with Fas and truncated BID (tBID) physically. These interactions abruptly diminish after hyperoxia. Deletion of p62 robustly increases tBID and cleaved caspase 3, implicating an anti-apoptotic effect. This anti-apoptotic effect of p62 is further confirmed by measuring caspase activities, cleaved PARP and cell viability. Deletion of the p62 PBI domain or ...
Source: American Journal of Respiratory Cell and Molecular Biology - January 18, 2013 Category: Molecular Biology Authors: Liang X, Wei SQ, Lee SJ, Fung JK, Zhang M, Tanaka A, Choi AM, Jin Y Tags: Am J Respir Cell Mol Biol Source Type: research

Synergy of IL-27 and TNF-α in regulating CXCL10 expression in lung fibroblasts: implications in airway inflammation.
In this study, we investigated whether IL-27 modulated the synthesis of CXCL10 in primary human lung fibroblasts (HLF). HLF were activated by IL-27 alone, or in combination with other cytokines. CXCL10 synthesis was measured by real-time PCR and ELISA. Examination of transcriptional regulation was performed via transient transfection of promoter constructs, whereas mRNA stability was assessed by actinomycin D chase and real-time PCR. The underlying signaling pathways were studied by Western blot and intracellular staining using flow cytometry. Our results demonstrated that IL-27 induced and synergized with TNF-α to upregu...
Source: American Journal of Respiratory Cell and Molecular Biology - January 18, 2013 Category: Molecular Biology Authors: Dong S, Zhang X, He Y, Xu F, Li D, Xu W, Wang H, Yin Y, Cao J Tags: Am J Respir Cell Mol Biol Source Type: research

Defluviimonas aestuarii sp. nov., a marine bacterium isolated from a tidal flat of South Sea in Korea and emended description of the genus Defluviimonas Foesel et al. 2011.
Abstract A novel Gram-staining-negative, strictly aerobic bacterium, designated BS14T, was isolated from a marine sea-tidal flat of South Sea in Korea. Colonies were opaque-white, smooth and circular on marine agar. Cells were moderately halophilic, non-motile rods showing catalase- and oxidase-positive reactions. Growth of strain BS14T was observed at 5-40 °C (optimum: 30 °C), pH 6.5-9.5 (optimum: 7.0-7.5) and 0-10 % (w/v) of NaCl (optimum: 1-1.5 %). The G+C content of the genomic DNA was 61.6 mol%. Strain BS14T contained ubiquinone-10 (Q-10) as the sole respiratory quinone and summed feature 8 (comprising C18:1...
Source: International Journal of Systematic and Evolutionary Microbiology - January 18, 2013 Category: Microbiology Authors: Math RK, Jin HM, Jeong SH, Jeon CO Tags: Int J Syst Evol Microbiol Source Type: research

Early estimates of seasonal influenza vaccine effectiveness - United States, january 2013.
Abstract In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months. Each season since 2004-05, CDC has estimated the effectiveness of seasonal influenza vaccine to prevent influenza-associated, medically attended acute respiratory infection (ARI). This season, early data from 1,155 children and adults with ARI enrolled during December 3, 2012-January 2, 2013 were used to estimate the overall effectiveness of seasonal influenza vaccine for preventing laboratory-confirmed influenza virus infection associated with medically attended ARI. After adjustment for st...
Source: MMWR Morb Mortal Wkl... - January 18, 2013 Category: Epidemiology Authors: Centers for Disease Control and Prevention (CDC) Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: A national survey
CONCLUSIONSOver the period of 2001 to 2009, there was a steady increase in the number of hospitalizations with a discharge diagnosis of ARF, with a decrease in inpatient mortality. There was a significant shift during this time toward the use of NIV, with a decrease in the rates of IMVuse. Journal of Hospital Medicine 2013. © 2013 Society of Hospital Medicine
Source: Journal of Hospital Medicine - January 18, 2013 Category: Hospital Management Authors: Mihaela S. Stefan, Meng‐Shiou Shieh, Penelope S. Pekow, Michael B. Rothberg, Jay S. Steingrub, Tara Lagu, Peter K. Lindenauer Tags: Original Research Source Type: research

REPORT: NDUFA9 in Complex I Assembly [Molecular Bases of Disease]
Transcription activator-like effector nucleases (TALENs) represent a promising approach for targeted knock-out of genes in cultured human cells. We used TALEN-technology to knock out the nuclear gene encoding NDUFA9, a subunit of mitochondrial respiratory chain complex I in HEK293T cells. Screening for the knock-out revealed a mixture of NDUFA9 cell clones that harbored partial deletions of the mitochondrial N-terminal targeting signal but were still capable of import. A cell line lacking functional copies of both NDUFA9 alleles resulted in a loss of NDUFA9 protein expression, impaired assembly of complex I, and cells inca...
Source: Journal of Biological Chemistry - January 18, 2013 Category: Chemistry Authors: Stroud, D. A., Formosa, L. E., Wijeyeratne, X. W., Nguyen, T. N., Ryan, M. T. Tags: Reports Source Type: research

A 17 year-old girl with a demyelinating disease requiring mechanical ventilation: a case report
Conclusions: Demyelinating diseases can cause acute respiratory failure when the spinal cord is affected. Severe forms of these diseases, making necessary ICU admission, is less frequently reported. Intensivists should be aware of the features of these rare diseases.
Source: BMC Research Notes - January 18, 2013 Category: Research Authors: Chrysostomos KatsenosDespoina AndroulakiStavroula LyraTheodoros TsoutsourasCostas Mandragos Source Type: research

The prevalence and risk factors of allergic and respiratory symptoms in a regional cohort of extremely low birth weight children (
Background: Children who were
Source: Italian Journal of Pediatrics - January 18, 2013 Category: Pediatrics Authors: Kwinta PrzemkoLis GrzegorzKlimek MalgorzataGrudzien AndrzejTomasik TomaszKarolina PoplawskaPietrzyk Jozef Source Type: research

Glutathione‐S‐transferase P1, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta‐analysis
ConclusionA genetic influence of the GSTP1 gene cannot be ruled out, but the magnitude of the effect is a matter of further research. In conclusion, the interplay between gene and environments is complex and remains subject of further study.
Source: Allergy - January 18, 2013 Category: Allergy & Immunology Authors: C. G. Tischer, A. Gref, M. Standl, M. Bauer, A. Bergström, M. Brauer, C. Carlsten, U. Gehring, R. Granell, J. Henderson, M. Kerkhof, M. MacNutt, E. Melén, M. Wickman, J. Heinrich Tags: Original Article Source Type: research

Three-step management of pneumothorax: time for a re-think on initial management
In this report, we systematically review published randomized controlled trials of the different treatments of primary spontaneous pneumothorax, point out controversial issues and finally propose a three-step strategy for the management of pneumothorax. There are three important characteristics of pneumothorax: potentially lethal respiratory dysfunction; air leak, which is the obvious cause of the disease; frequent recurrence. These three characteristics correspond to the three steps. The central idea of the strategy is that the lung should not be expanded rapidly, unless absolutely necessary. The primary objective of both...
Source: Interactive CardioVascular and Thoracic Surgery - January 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kaneda, H., Nakano, T., Taniguchi, Y., Saito, T., Konobu, T., Saito, Y. Tags: Thoracic Source Type: research

Lower tidal volume at initiation of mechanical ventilation may reduce progression to acute respiratory distress syndrome - a systematic review
Conclusions: In mechanically ventilated patients without ARDS at the time of endotracheal intubation, the majority of data favors lower tidal volume to reduce progression to ARDS. However, due to significant heterogeneity in the data, no definitive recommendations can be made. Further randomized controlled trials examining the role of lower tidal volumes in patients without ARDS, controlling for ARDS risk, are needed.
Source: Critical Care - January 18, 2013 Category: Intensive Care Authors: Brian FullerNicholas MohrAnne DrewryChristopher Carpenter Source Type: research

In situ molecular identification of the Influenza A (H1N1) 2009 Neuraminidase in patients with severe and fatal infections during a pandemic in Mexico City
Conclusions: We have successfully amplified specific influenza A (H1N1) NA sequences using stored clinical material; results suggest that this strategy could be useful when clinical RNA samples are quantity limited, or when poor quality is obtained. Here, we provide a very sensitive method that specifically detects the neuraminidase viral RNA in lung samples from patients who died from pneumonia caused by Influenza A (H1N1) outbreak in Mexico City.
Source: BMC Infectious Diseases - January 18, 2013 Category: Infectious Diseases Authors: Rodolfo Ocadiz-DelgadoMartha Albino-SanchezEnrique Garcia-VillaMaria Aguilar-GonzalezCarlos CabelloDora RoseteFidencio MejiaMaria Manjarrez-ZavalaCarmen Ondarza-AguileraRosa Rivera-RosalesPatricio Gariglio Source Type: research

C-reactive protein, haptoglobin, serum amyloid A and pig major acute phase protein response in pigs simultaneously infected with H1N1 swine influenza virus and Pasteurella multocida
Conclusions: The results of current study confirmed that monitoring of APP may revealed ongoing infection, and in this way may be useful in selecting clinically healthy pigs (i.e. before integration into an uninfected herd). Present results corroborated our previous findings that SAA could be a potentially useful indicator in experimental infection studies (e.g. vaccine efficiency investigations) or as a marker for disease severity, because of correlation observed between its concentration in serum and disease severity (lung scores, clinical scores).
Source: BMC Veterinary Research - Latest articles - January 18, 2013 Category: Veterinary Research Authors: Malgorzata Pomorska-MólIwona Markowska-DanielKrzysztof KwitKatarzyna StepniewskaZygmunt Pejsak Source Type: research

Bronchoscopy as an indicator of tracheobronchial fungal infection in non‐neutropenic intensive‐care unit patients
Abstract We aimed to establish that a bronchoscopic view can be as reliable as microbiology, and support an empirical tracheobronchial fungal infection (TBFI) treatment decision. We retrospectively studied 95 respiratory failure patients with suspected TBFI admitted to the intensive‐care unit (ICU) in 2008 with sticky secretions, hyperaemic mucosa, and whitish plaques on bronchoscopic view. Patients not suspected of having TBFI were chosen as a control group (n = 151). Broncheoalveolar lavage (BAL) fluid was cultured, and biopsy samples were taken from the lesions. Biopsy samples positive for fungi were defined as ‘p...
Source: Clinical Microbiology and Infection - January 18, 2013 Category: Microbiology Authors: Ö. Yazıcıoğlu Moçin, Z. Karakurt, F. Aksoy, G. Güngör, M. Partal, N. Adıgüzel, E. Acartürk, S. Batı Kutlu, R. Baran, H. Erdem Tags: Original Article Source Type: research

Human leukocyte antigen-G expression in differentiated human airway epithelial cells: lack of modulation by Th2-associated cytokines
Conclusions: These data demonstrate the constitutive expression of a T lymphocyte regulatory molecule in differentiated human airway epithelial cells that is not modulated by Th2-associated cytokines.
Source: Respiratory Research - January 18, 2013 Category: Respiratory Medicine Authors: Steven WhiteDagan LoiselRandi SternBharathi LaxmanTimothy FlorethBertha Marroquin Source Type: research

Unilateral phrenic nerve lesion in Lyme neuroborreliosis
Conclusion: Although Lyme neuroborreliosis is a rare cause of diaphragmatic weakness, it should be considered in the differential workup because of its potentially treatable nature.
Source: BioMed Central - January 17, 2013 Category: Journals (General) Authors: Marija DjukicJörg LarsenPaul LingorRoland Nau Source Type: research

[Staging of non-small cell lung cancer using CT and integrated PET-CT.]
Abstract Introduction. Lung cancer is the leading cause of death from cancer in developed countries. Radiological imaging methods are the basic methods in early diagnosis of this disease. TNM classification is a very important tool for optimal treatment in non-small lung cancer (NSCLC). Conventional radiological techniques allow the evaluation of the stage on the basis of anatomical changes only, while PET-CT provides information about the biochemical processes that may precede anatomical changes. The aim of this study was to compare the accuracy and sensitivity of CT and PET-CT in the staging of NSCLC. Material a...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Opoka L, Kunikowska J, Podgajny Z, Błasińska-Przerwa K, Burakowska B, Oniszh K, Gola M, Langfort R, Rudziński P, Bestry I, Roszkowski-Śliż K Tags: Pneumonol Alergol Pol Source Type: research

Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke.
Conclusions. As indicated, acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects. PMID: 23258467 [PubMed - in process]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Krakowiak A, Hałatek T, Nowakowska-Świrta E, Winnicka R, Politański P, Swiderska-Kiełbik S Tags: Pneumonol Alergol Pol Source Type: research

[Usefulness of NT-proBNP serum level in the diagnosis of dyspnea in COPD patients.]
Conclusions. 1. In the group of stable COPD patients there were no differences between NT-proBNP serum concentration according to GOLD staging, BODE index, and mMRC breathlessness scale. 2. The NT-proBNP serum concentration was statistically significantly higher in the group of COPD patients with the concomitant cardiovascular disease. 3. In patients with chronic dyspnoea testing of serum NT-proBNP may be useful in the detection of patients with cardiovascular problems, who require more intensive therapy. PMID: 23258468 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Rubinsztajn R, Nasiłowski J, Przybyłowski T, Karwat K, Chazan R Tags: Pneumonol Alergol Pol Source Type: research

[Outcome after PET-CT based radiotherapy for non-small cell lung cancer.]
Conclusions. The high early mortality rate in the patients disqualified from curative radiotherapy after PET-CT suggests the potential value of PET-CT for improving the radiotherapy outcome. However, this benefit seems to be limited in stage III patients. PMID: 23258469 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Socha J, Kołodziejczyk M, Kępka L Tags: Pneumonol Alergol Pol Source Type: research

[Occult bronchial foreign bodies - analysis of own material.]
Conclusion. OBFB is a rare condition, but has to be taken into consideration as a cause of chest radiological pathology and in patients with chronic and/or recurrent inflammatory disease of the respiratory system. PMID: 23258470 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Szafrański W, Dobielski J, Papiewski W, Czechowska U Tags: Pneumonol Alergol Pol Source Type: research

[Genetic variants of alpha-1 antitrypsin: classification and clinical implications.]
Abstract Inherited alpha-1 antitrypsin deficiency is listed among the three most common genetic disorders in Caucasians. It considerably increases the risk of progressive obstructive lung diseases, mostly chronic obstructive pulmonary disease, as well as chronic liver disorders, hepatitis, cirrhosis, and cancer. It is estimated that more than 5.5% of the Polish population carries one of the most common deficiency phenotypes, which might be relatively easily detected due to low alpha-1 antitrypsin serum concentration. However, as well as being quantitative, alpha-1 antitrypsin deficiency might also be qualitative. T...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Popławska B, Janciauskiene S, Chorostowska-Wynimko J Tags: Pneumonol Alergol Pol Source Type: research

[Treatment of non-small cell lung cancer - where we are?]
Abstract Lung cancer is the most common cancer in Poland and in the world, unfortunately diagnosed too late, and combined with a very poor prognosis. For most patients with NSCLC the only possibility of treatment is palliative therapy, including chemotherapy and, in the recent years, molecular targeted therapy. In first-line treatment, cisplatine-based "doublets" are most effective, and in second-line, pemetreksed and docetaxel are used. Recently, maintenance chemotherapy has been introduced. Although standard chemotherapy improves the quality of life in the patients with advanced NSCLC, due to significant toxicity...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Milanowski J, Szmygin-Milanowska K Tags: Pneumonol Alergol Pol Source Type: research

[Pneumocystosis in a patient with lymphangioleiomyomatosis.]
Abstract A 47-year-old, non-smoking woman was admitted to the National Tuberculosis and Lung Diseases Research Institute for diagnosis of progressive exertional dyspnoea and numerous small thin-walled, air-filled cysts equally distributed throughout both lungs revealed in HRCT (high resolution computed tomography) examination. Histological assessment of specimens obtained by open lung biopsy revealed proliferation of immature smooth muscle, showing the expression of the antigen HMB45. On this basis, diagnosis of lymphangioleiomyomatosis was established. The disease caused essential ventilation damage of the lungs (...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Mydłowski T, Radzikowska E, Oniszh K, Szczepulska-Wójcik E, Jaguś P, Wiatr E Tags: Pneumonol Alergol Pol Source Type: research

[Nodular lymphoid hyperplasia - a rare case of lymphoproliferative disorder of the lungs.]
Abstract Nodular lymphoid hyperplasia (NLH) belongs to a very rare, mild, lymphoproliferative disease of unestablished aetiology historically included in the group of pseudolymphomas. Its existence was controversial for many years, until modern techniques of pathomorphological diagnosis approved it as a separate entity of lung disease. It manifests in the form of well limited nodules localized in the lungs, which are mostly identified accidentally. Clinical symptoms are rare and nonspecific; the disease usually occupies only one lung. Pathomorphological diagnosis requires immunohistochemical designation of expressi...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Rogoziński P, Bruliński K, Malinowski E, Wandzel P, Kucharzewski M Tags: Pneumonol Alergol Pol Source Type: research

[Case finding COPD diagnosis in high risk groups in Poland in the years.]
PMID: 23271620 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Zieliński J Tags: Pneumonol Alergol Pol Source Type: research

[Advances in pulmonology in year 2012.]
PMID: 23271621 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Augustynowicz-Kopeć E, Bestry I, Korzeniewska-Koseła M, Kuś J, Michałowska I, Opoka L, Radzikowska E, Tomkowski W, Zieliński J Tags: Pneumonol Alergol Pol Source Type: research

Am J Respir Cell Mol Biol; +28 new citations
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Cell Mol Biol These pubmed results were generated on 2013/01/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Am J Respir Cell Mol... - January 17, 2013 Category: Respiratory Medicine Tags: Report Source Type: research

Am J Physiol Lung Cell Mol Physiol; +59 new citations
59 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2013/01/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Am J Physiol Lung Ce... - January 17, 2013 Category: Respiratory Medicine Tags: Report Source Type: research

Trends in Mortality Risk by Education Level and Cause of Death Among US White Women From 1986 to 2006.
Conclusions. Mortality disparities among White women widened across 1986 to 2006 partially because of causes of death for which smoking is a major risk factor. A comprehensive policy framework should address the social conditions that influence smoking among disadvantaged women. (Am J Public Health. Published online ahead of print January 17, 2013: e1-e7. doi:10.2105/AJPH.2012.301128). PMID: 23327260 [PubMed - as supplied by publisher]
Source: American Journal of Public Health - January 17, 2013 Category: Global & Universal Authors: Montez JK, Zajacova A Tags: Am J Public Health Source Type: research

Effects of Cardiovascular Drugs on Mortality in Severe COPD: A Time-Dependent Analysis.
CONCLUSIONS: This study supports that antiplatelet drugs improve survival, whereas beta blockers decrease survival in oxygen-dependent COPD. PMID: 23328521 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Ekström MP, Bornefalk Hermansson A, Ström KE Tags: Am J Respir Crit Care Med Source Type: research

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation.
Conclusions. Acute hypoxia induces superoxide release from Complex III of smooth muscle cells. These oxidant signals diffuse into the cytosol and trigger increases in [Ca2+]i that cause acute hypoxic pulmonary vasoconstriction. PMID: 23328522 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT Tags: Am J Respir Crit Care Med Source Type: research

Re-Establishment of Recipient-Associated Microbiota in the Lung Allograft is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome.
CONCLUSIONS: Re-colonization of the allograft by Pseudomonas in CF individuals is not associated with BOS. In general, re-establishment of pre-transplant lung populations in the allograft appears to have a protective effect against BOS, whereas de novo acquisition of microbial populations often belonging to the same genera may increase the risk of BOS. PMID: 23328523 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Willner DL, Hugenholtz P, Yerkovich ST, Tan ME, Daly JN, Lachner N, Hopkins PM, Chambers DC Tags: Am J Respir Crit Care Med Source Type: research

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
CONCLUSIONS: Hypoxia inducible factor 1-mediated increase in adipose Angptl4 and ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea. PMID: 23328524 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY Tags: Am J Respir Crit Care Med Source Type: research

Mortality by Level of Emphysema and Airway Wall Thickness.
CONCLUSIONS: AWT affected mortality with increasing degree of emphysema, whereas CT measure of emphysema was a strong independent mortality predictor. PMID: 23328525 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Johannessen A, Skorge TD, Bottai M, Grydeland TB, Nilsen RM, Coxson H, Dirksen A, Omenaas E, Gulsvik A, Bakke P Tags: Am J Respir Crit Care Med Source Type: research

Quantifying Health Services Use for Chronic Obstructive Pulmonary Disease.
Conclusions Individuals with COPD use large and disproportionate amounts of health services. Strategies that target this group are needed to improve their health and minimize their need for health services. PMID: 23328526 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Gershon AS, Guan J, Victor JC, Goldstein R, To T Tags: Am J Respir Crit Care Med Source Type: research

The COX2/PGE2 Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts.
Conclusion. PGE2 is a critical component of an amplifying and self-perpetuating circle inducing senescence and inflammation in COPD fibroblasts. Modulating the described PGE2 signaling pathway could provide new basis to dampen senescence and senescence-associated inflammation in COPD. PMID: 23328527 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Dagouassat M, Gagliolo JM, Chrusciel S, Bourin MC, Duprez C, Caramelle P, Boyer L, Hue S, Stern JB, Validire P, Longrois D, Norel X, Dubois-Randé JL, Le Gouvello S, Adnot S, Boczkowski J Tags: Am J Respir Crit Care Med Source Type: research

ADCYAP1R1 and Asthma in Puerto Rican Children.
CONCLUSIONS: Epigenetic and genetic variants in ADCYAP1R1 are associated with asthma in Puerto Rican children. PMID: 23328528 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Chen W, Boutaoui N, Brehm JM, Han YY, Schmitz C, Cressley A, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Baccarelli AA, Weeks DE, Kolls JK, Canino G, Celedón JC Tags: Am J Respir Crit Care Med Source Type: research

Plasma Angiopoietin-2 Predicts the Onset of Acute Lung Injury in Critically Ill Patients.
CONCLUSIONS: Plasma biomarkers such as Ang-2 can improve clinical prediction scores and identify patients at high risk for ALI. In addition, the early rise of Ang-2 emphasizes the importance of endothelial injury in the early pathogenesis of ALI. PMID: 23328529 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS Tags: Am J Respir Crit Care Med Source Type: research