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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial
Publication date: Available online 2 December 2014 Source:The Lancet Respiratory Medicine Author(s): Adrian R Martineau , Wai Yee James , Richard L Hooper , Neil C Barnes , David A Jolliffe , Claire L Greiller , Kamrul Islam , David McLaughlin , Angshu Bhowmik , Peter M Timms , Raj K Rajakulasingam , Marion Rowe , Timothy R Venton , Aklak B Choudhury , David E Simcock , Mark Wilks , Amarjeet Degun , Zia Sadique , William R Monteiro , Christopher J Corrigan , Catherine M Hawrylowicz , Christopher J Griffiths Background Patients with chronic obstructive pulmonary disease (COPD) often have vitamin D deficiency, which is ass...
Source: The Lancet Respiratory Medicine - December 2, 2014 Category: Respiratory Medicine Source Type: research

Emiliania huxleyi endures N-limitation with an efficient metabolic budgeting and effective ATP synthesis
Conclusions: The use of the ornithine-urea cycle to budget the cellular nitrogen in situations of limitation resembles the responses observed earlier in diatoms. This suggests that underlying biochemical mechanisms are conserved among distant clades of marine phototrophic protists. The ornithine-urea cycle and proline oxidation appear to constitute a sensory-regulatory system that monitors and controls cellular nitrogen budgets under limitation. The similarity between the responses of the life-cycle stages, despite the usage of different genes, also indicates a strong functional consistency in the responses to nitrogen-lim...
Source: BMC Genomics - December 2, 2014 Category: Genetics & Stem Cells Authors: Sebastian RokittaPeter Von DassowBjörn RostUwe John Source Type: research

Evaluation of In Silico Models for the Identification of Respiratory Sensitizers
This article presents the evaluation of structure–activity relationship (SAR) models as potential methods to prospectively conclude on the sensitization potential of LMW chemicals. The predictive performance of the SARs calculated from their training sets was compared to their performance on a dataset of newly identified respiratory sensitizers and nonsensitizers, derived from literature. The predictivity of the available SARs for new substances was markedly lower than their published predictive performance. For that reason, no single SAR model can be considered sufficiently reliable to conclude on potential LMW resp...
Source: Toxicological Sciences - December 2, 2014 Category: Toxicology Authors: Dik, S., Ezendam, J., Cunningham, A. R., Carrasquer, C. A., van Loveren, H., Rorije, E. Tags: COMPUTATIONAL MODEL OF RESPIRATORY SENSITIZATION Source Type: research

Evolution of unidirectional flow in Diapsida [Evolution]
The generally accepted framework for the evolution of a key feature of the avian respiratory system, unidirectional airflow, is that it is an adaptation for efficiency of gas exchange and expanded aerobic capacities, and therefore it has historically been viewed as important to the ability of birds to fly and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - December 2, 2014 Category: Science Authors: Cieri, R. L., Craven, B. A., Schachner, E. R., Farmer, C. G. Tags: Biological Sciences Source Type: research

Involvement of palmitate/Ca2+(Sr2+)-induced pore in the cycling of ions across the mitochondrial membrane
Publication date: February 2015 Source:Biochimica et Biophysica Acta (BBA) - Biomembranes, Volume 1848, Issue 2 Author(s): Galina D. Mironova , Nils-Erik L. Saris , Natalia V. Belosludtseva , Alexey V. Agafonov , Alexander B. Elantsev , Konstantin N. Belosludtsev The palmitate/Ca2+-induced (Pal/Ca2+) pore, which is formed due to the unique feature of long-chain saturated fatty acids to bind Ca2+ with high affinity, has been shown to play an important role in the physiology of mitochondria. The present study demonstrates that the efflux of Ca2+ from rat liver mitochondria induced by ruthenium red, an inhibitor of the ener...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - December 2, 2014 Category: Biochemistry Source Type: research

Powerhouse down: Complex II dissociation in the respiratory chain
Publication date: November 2014 Source:Mitochondrion, Volume 19, Part A Author(s): Ming-Shih Hwang , Jakub Rohlena , Lan-Feng Dong , Jiri Neuzil , Stefan Grimm Complex II of the respiratory chain (RC) recently emerged as a prominent regulator of cell death. In both cancer cells as well as neurodegenerative diseases, mutations in subunits have been found along with other genetic alterations indirectly affecting this complex. Anticancer compounds were developed that target complex II and cause cell death in a tumor-specific way. Our mechanistic understanding of how complex II is activated for cell death induction has recen...
Source: Mitochondrion - December 2, 2014 Category: Biochemistry Source Type: research

Acute Respiratory Failure and Active Bleeding Are the Important Fatality Predictive Factors for Severe Dengue Viral Infection
by Kamolwish Laoprasopwattana, Wanwipa Chaimongkol, Pornpimol Pruekprasert, Alan Geater Objective To determine the outcome of severe dengue viral infection (DVI) and the main dengue fatality risk factors. Study design The medical records of patients aged (Source: PLoS One)
Source: PLoS One - December 2, 2014 Category: Biomedical Science Authors: Kamolwish Laoprasopwattana et al. Source Type: research

Understanding History, and Not Repeating It. Neuroprotection for Acute Ischemic Stroke: From Review to Preview
Ischemic stroke is a major cause of morbidity and mortality worldwide. According to the American Heart Association and the National Institute of Neurological Disease and Stroke, an estimated 795,000 Americans suffer a stroke each year, with ∼87% being ischemic [1]. Annually, stroke accounts for over 220,000 deaths, 4th overall behind cardiac disease, cancer, and chronic lower respiratory disease [2]. It is the leading cause of long-term disability in the US, with about ¼ of the survivors needing assistance with activities of daily living six months after their ictus [1]. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - December 2, 2014 Category: Neurosurgery Authors: Stephen Grupke, Jason Hall, Michael Dobbs, Gregory J. Bix, Justin F. Fraser Source Type: research

The first wheezing episode: respiratory virus etiology, atopic characteristics and illness severity
ConclusionsA respiratory virus infection can be detected in all first‐time wheezing children. Rhinovirus dominated the findings and was linked to atopic characteristics, prolonged cough and parental smoking.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - December 2, 2014 Category: Allergy & Immunology Authors: Riitta Turunen, Annamari Koistinen, Tytti Vuorinen, Benedict Arku, Maria Söderlund‐Venermo, Olli Ruuskanen, Tuomas Jartti Tags: Original Source Type: research

Evidence-based clinical practice manual: Cardiopulmonary-cerebral resuscitation
Publication date: Available online 2 December 2014 Source:Colombian Journal of Anesthesiology Author(s): José Ricardo-Navarro Vargas , Hernando Matiz-Camacho , Javier Osorio-Esquivel Cardio respiratory arrest in adults arises as a consequence of coronary artery disease in more than 60% of cases. At present, it is considered a public health problem. It is important to keep in mind that prevention, through the adoption of healthy habits, is the principle contributor to the reduction of morbimortality. Nevertheless, when a malign arrhythmia that leads to cardiac arrest presents itself, the outcomes are directly related to ...
Source: Colombian Journal of Anesthesiology - December 2, 2014 Category: Anesthesiology Source Type: research

Perinatal conditions related to growth restriction and inflammation are associated with an increased risk of bronchopulmonary dysplasia
ConclusionGrowth restriction and inflammation increased the risk of BPD in preterm infants and pre‐labour preterm rupture of membranes, small for gestational age, low Apgar score or need for resuscitation should raise clinical suspicions.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - December 2, 2014 Category: Pediatrics Authors: Lena Eriksson, Bengt Haglund, Viveca Odlind, Maria Altman, Uwe Ewald, Helle Kieler Tags: Regular Article Source Type: research

Airway compromise in children exposed to single use laundry detergent pods: a poison center observational case series
Single-use laundry detergent pods (LDP) were introduced to the United States in 2010 but had been available in Europe as early as 2001. Case reports of unintentional exposures noted vomiting, ocular injuries, respiratory depression and central nervous system depression. We summarize clinical effects from unintentional LDP exposures reported to a single poison center over 15months. Methods: Electronic poison center records were searched using verbatim field and both product and generic codes to identify laundry pod exposures from January 1, 2012 through April 9, 2013. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 2, 2014 Category: Emergency Medicine Authors: Paul E. Stromberg, Michele H. Burt, S. Rutherfoord Rose, Kirk L. Cumpston, Michael P. Emswiler, Brandon K. Wills Tags: Original Contribution Source Type: research

Multidisciplinary Management of Paget-Schroetter Syndrome. A Case Series of Eight Patients.
We describe a series of eight cases treated in this way. None of the patients showed signs of complications, and an early return to regular activities with no PTS was observed in 90% of cases. PMID: 25446871 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - December 2, 2014 Category: Respiratory Medicine Authors: Rosa Salazar V, Otálora Valderrama SD, Hernández Contreras ME, García Pérez B, Arroyo Tristán AD, García Méndez MD Tags: Arch Bronconeumol Source Type: research

Neuromuscular and Neuropsychological Assessments in Survivors of Acute Respiratory Distress Syndrome: Exploratory Comparisons with an At-Risk Cohort
Conclusions In this single-center population-based cohort study, survivors of ARDS in the community had similar reported functional impairment and depression prevalence compared to an at-risk cohort that did not develop ARDS. (Source: Neurocritical Care)
Source: Neurocritical Care - December 2, 2014 Category: Neurology Source Type: research

Correlating Minimum Inhibitory Concentrations of ofloxacin and moxifloxacin with mutations using the Genotype MTBDR Assay
To correlate gyrA mutations found on the Genotype MTBDRsl assay in Mycobacterium tuberculosis (MTB) isolates with Minimum Inhibitory Concentrations (MICs) to the fluoroquinolones compounds ofloxacin (OFX) and moxifloxacin (MXF). (Source: Tuberculosis)
Source: Tuberculosis - December 2, 2014 Category: Respiratory Medicine Authors: Priti Kambli, Kanchan Ajbani, Meeta Sadani, Chaitali Nikam, Anjali Shetty, Zarir Udwadia, Timothy C. Rodwell, Antonino Catanzaro, Camilla Rodrigues Tags: Drug Discovery and Resistance Source Type: research

Interventional Pulmonology
Semin Respir Crit Care Med 2014; 35: 629-630DOI: 10.1055/s-0034-1395792Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Feller-Kopman, DavidYarmus, Lonny Tags: Preface Source Type: research

Training in Interventional Pulmonology
This article will review the evolution of the field of IP as well as the pathways to learn advanced procedural techniques.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Feller-Kopman, DavidYarmus, Lonny Source Type: research

Convex Probe Endobronchial Ultrasound
Semin Respir Crit Care Med 2014; 35: 636-644DOI: 10.1055/s-0034-1395498Convex probe endobronchial ultrasound (EBUS) is a minimally invasive diagnostic technique that allows real-time sampling of mediastinal and hilar lymph nodes and central pulmonary lesions. Its utility in diagnosing both malignant and nonmalignant diseases has led to an increased uptake and use by pulmonologists over the past decade. Because of the robust evidence supporting its safety and diagnostic yield, EBUS is now the first guideline recommended test for staging in non-small cell lung cancer (NSCLC). It has also a role in providing tissue for molecu...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Bade, BrettFurukawa, BrianTanner, Nichole T. Source Type: research

Radial Probe Endobronchial Ultrasound and Novel Navigation Biopsy Techniques
This article summarizes the technical platforms, procedures, and clinical evidence for these emerging technologies.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Chenna, PraveenChen, Alexander C. Source Type: research

Interventional Pulmonology for Asthma and Emphysema: Bronchial Thermoplasty and Bronchoscopic Lung Volume Reduction
This article is a review of bronchoscopic modalities for emphysema and asthma.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Miller, Russell J.Murgu, Septimiu D. Source Type: research

Rigid Bronchoscopy
This article will review information relevant to this technique and lay a foundation to be built upon for years to come.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Seminars in Respiratory and Critical Care Medicine)
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Alraiyes, Abdul HamidMachuzak, Michael S. Source Type: research

Ablative Therapies for Central Airway Obstruction
Semin Respir Crit Care Med 2014; 35: 681-692DOI: 10.1055/s-0034-1395501Central airway obstruction (CAO) is seen in malignant and nonmalignant airway disorders and can lead to significant morbidity and mortality. Endobronchial ablative therapies are used in conjunction with mechanical debridement to achieve hemostasis and restore airway patency. These therapies can be classified into modalities with immediate or delayed effect. Therapies with immediate effect include heat therapies (such as electrocautery, argon plasma coagulation, and laser) and cryorecanalization using a cryoprobe for tissue extraction. These modalities c...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Mahmood, KamranWahidi, Momen M. Source Type: research

Ultrasound-Guided Pleural Access
Semin Respir Crit Care Med 2014; 35: 693-705DOI: 10.1055/s-0034-1395794Ultrasonography of the thorax has become a more recognized tool in pulmonary medicine, thanks to continuing clinical research that has proven its many valuable roles in the day-to-day management of pulmonary and pleural diseases. Ultrasound examination is a cost-effective imaging modality that permits the pulmonologist to obtain information about the pathologies in the thorax without the risk of exposure to ionizing radiation, providing the examiner with real-time and immediate results. Its ease of use and training along with its portability to the pati...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Shojaee, SamiraArgento, A. Christine Source Type: research

Management of Pneumothorax and Prolonged Air Leak
Semin Respir Crit Care Med 2014; 35: 706-714DOI: 10.1055/s-0034-1395502Pneumothorax refers to the presence of air within the pleural cavity, which may arise from a spontaneous defect in the visceral pleural surface, or through iatrogenic or other thoracic trauma. The most common cause in the developed world is iatrogenic pneumothorax. Most frequently, it can be managed conservatively or through simple pleural aspiration or drainage. A persistent air leak, >2 days' duration, develops in one-third of patients. When patients are managed with chest drainage alone, the median time for resolution of air leak is longer in pati...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Slade, Mark Source Type: research

Management of Parapneumonic Effusions and Empyema
Semin Respir Crit Care Med 2014; 35: 715-722DOI: 10.1055/s-0034-1395503Pleural infection remains a common and serious respiratory condition with important implications for patients and health-care services. This review will cover the management of pleural infection including medical treatment, the role of intrapleural agents and surgical treatment. We discuss the directions that future research in this important area might take. Increasing incidence of pleural infection has been reported worldwide without a clear explanation. The pathogens responsible for pleural infection differ from those in pneumonia. Proper antibiotic ...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Psallidas, IoannisCorcoran, John P.Rahman, Najib M. Source Type: research

Current Controversies in the Management of Malignant Pleural Effusions
Semin Respir Crit Care Med 2014; 35: 723-731DOI: 10.1055/s-0034-1395795Malignant pleural effusion (MPE) can complicate most malignancies and is a common clinical problem presenting to respiratory and cancer care physicians. Despite its frequent occurrence, current knowledge of MPE remains limited and controversy surrounds almost every aspect in its diagnosis and management. A lack of robust data has led to significant practice variations worldwide, inefficiencies in healthcare provision, and threats to patient safety. Recent studies have highlighted evolving concepts in MPE care that challenge traditional beliefs. Advancin...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Azzopardi, MareePorcel, José M.Koegelenberg, Coenraad F. N.Gary Lee, Y. C.Fysh, Edward T. H. Source Type: research

Medical Thoracoscopy
Semin Respir Crit Care Med 2014; 35: 732-743DOI: 10.1055/s-0034-1395796The burden of pleural diseases continues to rise and affects an increasingly complex and aging patient population. As such, thoracentesis is one of the most common procedures performed by respiratory physicians, as pleural fluid analysis can establish the diagnosis of pleural effusions in approximately 75% of the cases. When a diagnosis is not reached, options include image-guided biopsies, only possible when focal pleural lesions can be identified by computed tomography or ultrasound; closed pleural biopsies, associated with a relatively low diagnostic...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Skalski, Joseph H.Astoul, Philippe J.Maldonado, Fabien Source Type: research

Interventional Pulmonology in the Intensive Care Unit: Percutaneous Tracheostomy and Gastrostomy
Semin Respir Crit Care Med 2014; 35: 744-750DOI: 10.1055/s-0034-1395504Bedside percutaneous tracheostomy and gastrostomy tube placement are cost-effective and safe techniques employed in the management of critically ill patients requiring prolonged mechanical ventilation. Both procedures have been well characterized and studied in the surgical and gastroenterology literature. Recently the performance of these procedures by interventional pulmonologists have been reported. This review focuses on the role of the interventional pulmonologist in the ICU, specifically in regard to the placement of percutaneous tracheostomies an...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Belanger, AdamAkulian, Jason Source Type: research

Interventional Pulmonology in the Pediatric Population
Semin Respir Crit Care Med 2014; 35: 751-762DOI: 10.1055/s-0034-1395505Endoscopic airway interventions within pediatric populations vary considerably. Some of this variance may be related to institutional experience, however, may also be limited by operator experience and available equipment. Previous reports of pediatric bronchoscopic interventional procedures have been identified within the surgical literature; however, newer reports have identified other specialties participating in the care of these patients. Here, we will provide a review of the current relevant medical literature, including an evidence-based review o...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Gilbert, Christopher R.Wang, KoPenLee, Hans J. Source Type: research

The Future of Interventional Pulmonology
Semin Respir Crit Care Med 2014; 35: 763-768DOI: 10.1055/s-0034-1395506Interventional pulmonology (IP) is a maturing subspecialty of pulmonary medicine focused on advanced diagnostic and therapeutic pulmonary and thoracic medical procedures for a variety of illnesses. This rapidly growing field requires highly specific knowledge and skill sets beyond its parent specialty. While the future of IP will continue to show growth, we postulate on a few upcoming technologies which may influence the field and discuss some of the challenges associated with growth in IP.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY ...
Source: Seminars in Respiratory and Critical Care Medicine - December 2, 2014 Category: Respiratory Medicine Authors: Arias, SixtoLee, Hans J. Source Type: research

Obstructive sleep apnoea in children with craniofacial syndromes
Obstructive sleep apnoea syndrome (OSAS) is common in children. Craniofacial anomalies such as cleft palate are among the most common congenital conditions. Children with a variety of craniofacial conditions, including cleft palate, micrognathia, craniosynostosis, and midface hypoplasia are at increased risk for OSAS. Available evidence, which is largely limited to surgical case series and retrospective studies, suggests that OSAS can be successfully managed in these children through both surgical and non-surgical techniques. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - December 2, 2014 Category: Respiratory Medicine Authors: Christopher M. Cielo, Carole L. Marcus Source Type: research

Perceived 10-year change in respiratory health: Reliability and predictive ability
To investigate the usefulness of a self-reported respiratory health transition question over 10 years through reliability, ability to capture long-term asthma trajectory and predictive ability. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 2, 2014 Category: Respiratory Medicine Authors: Margaux Sanchez, Raphaëlle Varraso, Jean Bousquet, Françoise Clavel-Chapelon, Christophe Pison, Francine Kauffmann, Marc Humbert, Valérie Siroux Source Type: research