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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 21.

[Staging of non-small cell lung cancer using CT and integrated PET-CT.]
Abstract Introduction. Lung cancer is the leading cause of death from cancer in developed countries. Radiological imaging methods are the basic methods in early diagnosis of this disease. TNM classification is a very important tool for optimal treatment in non-small lung cancer (NSCLC). Conventional radiological techniques allow the evaluation of the stage on the basis of anatomical changes only, while PET-CT provides information about the biochemical processes that may precede anatomical changes. The aim of this study was to compare the accuracy and sensitivity of CT and PET-CT in the staging of NSCLC. Material a...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Opoka L, Kunikowska J, Podgajny Z, Błasińska-Przerwa K, Burakowska B, Oniszh K, Gola M, Langfort R, Rudziński P, Bestry I, Roszkowski-Śliż K Tags: Pneumonol Alergol Pol Source Type: research

Clara Cell protein and myeloperoxidase levels in serum of subjects after exposure to fire smoke.
Conclusions. As indicated, acute exposure to smoke induces injury at the alveolar level, which results in a transient increase of CC16 in serum of exposed subjects. PMID: 23258467 [PubMed - in process]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Krakowiak A, Hałatek T, Nowakowska-Świrta E, Winnicka R, Politański P, Swiderska-Kiełbik S Tags: Pneumonol Alergol Pol Source Type: research

[Usefulness of NT-proBNP serum level in the diagnosis of dyspnea in COPD patients.]
Conclusions. 1. In the group of stable COPD patients there were no differences between NT-proBNP serum concentration according to GOLD staging, BODE index, and mMRC breathlessness scale. 2. The NT-proBNP serum concentration was statistically significantly higher in the group of COPD patients with the concomitant cardiovascular disease. 3. In patients with chronic dyspnoea testing of serum NT-proBNP may be useful in the detection of patients with cardiovascular problems, who require more intensive therapy. PMID: 23258468 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Rubinsztajn R, Nasiłowski J, Przybyłowski T, Karwat K, Chazan R Tags: Pneumonol Alergol Pol Source Type: research

[Outcome after PET-CT based radiotherapy for non-small cell lung cancer.]
Conclusions. The high early mortality rate in the patients disqualified from curative radiotherapy after PET-CT suggests the potential value of PET-CT for improving the radiotherapy outcome. However, this benefit seems to be limited in stage III patients. PMID: 23258469 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Socha J, Kołodziejczyk M, Kępka L Tags: Pneumonol Alergol Pol Source Type: research

[Occult bronchial foreign bodies - analysis of own material.]
Conclusion. OBFB is a rare condition, but has to be taken into consideration as a cause of chest radiological pathology and in patients with chronic and/or recurrent inflammatory disease of the respiratory system. PMID: 23258470 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Szafrański W, Dobielski J, Papiewski W, Czechowska U Tags: Pneumonol Alergol Pol Source Type: research

[Genetic variants of alpha-1 antitrypsin: classification and clinical implications.]
Abstract Inherited alpha-1 antitrypsin deficiency is listed among the three most common genetic disorders in Caucasians. It considerably increases the risk of progressive obstructive lung diseases, mostly chronic obstructive pulmonary disease, as well as chronic liver disorders, hepatitis, cirrhosis, and cancer. It is estimated that more than 5.5% of the Polish population carries one of the most common deficiency phenotypes, which might be relatively easily detected due to low alpha-1 antitrypsin serum concentration. However, as well as being quantitative, alpha-1 antitrypsin deficiency might also be qualitative. T...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Popławska B, Janciauskiene S, Chorostowska-Wynimko J Tags: Pneumonol Alergol Pol Source Type: research

[Treatment of non-small cell lung cancer - where we are?]
Abstract Lung cancer is the most common cancer in Poland and in the world, unfortunately diagnosed too late, and combined with a very poor prognosis. For most patients with NSCLC the only possibility of treatment is palliative therapy, including chemotherapy and, in the recent years, molecular targeted therapy. In first-line treatment, cisplatine-based "doublets" are most effective, and in second-line, pemetreksed and docetaxel are used. Recently, maintenance chemotherapy has been introduced. Although standard chemotherapy improves the quality of life in the patients with advanced NSCLC, due to significant toxicity...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Milanowski J, Szmygin-Milanowska K Tags: Pneumonol Alergol Pol Source Type: research

[Pneumocystosis in a patient with lymphangioleiomyomatosis.]
Abstract A 47-year-old, non-smoking woman was admitted to the National Tuberculosis and Lung Diseases Research Institute for diagnosis of progressive exertional dyspnoea and numerous small thin-walled, air-filled cysts equally distributed throughout both lungs revealed in HRCT (high resolution computed tomography) examination. Histological assessment of specimens obtained by open lung biopsy revealed proliferation of immature smooth muscle, showing the expression of the antigen HMB45. On this basis, diagnosis of lymphangioleiomyomatosis was established. The disease caused essential ventilation damage of the lungs (...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Mydłowski T, Radzikowska E, Oniszh K, Szczepulska-Wójcik E, Jaguś P, Wiatr E Tags: Pneumonol Alergol Pol Source Type: research

[Nodular lymphoid hyperplasia - a rare case of lymphoproliferative disorder of the lungs.]
Abstract Nodular lymphoid hyperplasia (NLH) belongs to a very rare, mild, lymphoproliferative disease of unestablished aetiology historically included in the group of pseudolymphomas. Its existence was controversial for many years, until modern techniques of pathomorphological diagnosis approved it as a separate entity of lung disease. It manifests in the form of well limited nodules localized in the lungs, which are mostly identified accidentally. Clinical symptoms are rare and nonspecific; the disease usually occupies only one lung. Pathomorphological diagnosis requires immunohistochemical designation of expressi...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Rogoziński P, Bruliński K, Malinowski E, Wandzel P, Kucharzewski M Tags: Pneumonol Alergol Pol Source Type: research

[Case finding COPD diagnosis in high risk groups in Poland in the years.]
PMID: 23271620 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Zieliński J Tags: Pneumonol Alergol Pol Source Type: research

[Advances in pulmonology in year 2012.]
PMID: 23271621 [PubMed - as supplied by publisher]
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Augustynowicz-Kopeć E, Bestry I, Korzeniewska-Koseła M, Kuś J, Michałowska I, Opoka L, Radzikowska E, Tomkowski W, Zieliński J Tags: Pneumonol Alergol Pol Source Type: research

Am J Respir Cell Mol Biol; +28 new citations
28 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Respir Cell Mol Biol These pubmed results were generated on 2013/01/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Am J Respir Cell Mol... - January 17, 2013 Category: Respiratory Medicine Tags: Report Source Type: research

Am J Physiol Lung Cell Mol Physiol; +59 new citations
59 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Lung Cell Mol Physiol These pubmed results were generated on 2013/01/17PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
Source: Am J Physiol Lung Ce... - January 17, 2013 Category: Respiratory Medicine Tags: Report Source Type: research

Trends in Mortality Risk by Education Level and Cause of Death Among US White Women From 1986 to 2006.
Conclusions. Mortality disparities among White women widened across 1986 to 2006 partially because of causes of death for which smoking is a major risk factor. A comprehensive policy framework should address the social conditions that influence smoking among disadvantaged women. (Am J Public Health. Published online ahead of print January 17, 2013: e1-e7. doi:10.2105/AJPH.2012.301128). PMID: 23327260 [PubMed - as supplied by publisher]
Source: American Journal of Public Health - January 17, 2013 Category: Global & Universal Authors: Montez JK, Zajacova A Tags: Am J Public Health Source Type: research

Effects of Cardiovascular Drugs on Mortality in Severe COPD: A Time-Dependent Analysis.
CONCLUSIONS: This study supports that antiplatelet drugs improve survival, whereas beta blockers decrease survival in oxygen-dependent COPD. PMID: 23328521 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Ekström MP, Bornefalk Hermansson A, Ström KE Tags: Am J Respir Crit Care Med Source Type: research

Superoxide Generated at Mitochondrial Complex III Triggers Acute Responses to Hypoxia in the Pulmonary Circulation.
Conclusions. Acute hypoxia induces superoxide release from Complex III of smooth muscle cells. These oxidant signals diffuse into the cytosol and trigger increases in [Ca2+]i that cause acute hypoxic pulmonary vasoconstriction. PMID: 23328522 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT Tags: Am J Respir Crit Care Med Source Type: research

Re-Establishment of Recipient-Associated Microbiota in the Lung Allograft is Linked to Reduced Risk of Bronchiolitis Obliterans Syndrome.
CONCLUSIONS: Re-colonization of the allograft by Pseudomonas in CF individuals is not associated with BOS. In general, re-establishment of pre-transplant lung populations in the allograft appears to have a protective effect against BOS, whereas de novo acquisition of microbial populations often belonging to the same genera may increase the risk of BOS. PMID: 23328523 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Willner DL, Hugenholtz P, Yerkovich ST, Tan ME, Daly JN, Lachner N, Hopkins PM, Chambers DC Tags: Am J Respir Crit Care Med Source Type: research

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
CONCLUSIONS: Hypoxia inducible factor 1-mediated increase in adipose Angptl4 and ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea. PMID: 23328524 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY Tags: Am J Respir Crit Care Med Source Type: research

Mortality by Level of Emphysema and Airway Wall Thickness.
CONCLUSIONS: AWT affected mortality with increasing degree of emphysema, whereas CT measure of emphysema was a strong independent mortality predictor. PMID: 23328525 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Johannessen A, Skorge TD, Bottai M, Grydeland TB, Nilsen RM, Coxson H, Dirksen A, Omenaas E, Gulsvik A, Bakke P Tags: Am J Respir Crit Care Med Source Type: research

Quantifying Health Services Use for Chronic Obstructive Pulmonary Disease.
Conclusions Individuals with COPD use large and disproportionate amounts of health services. Strategies that target this group are needed to improve their health and minimize their need for health services. PMID: 23328526 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Gershon AS, Guan J, Victor JC, Goldstein R, To T Tags: Am J Respir Crit Care Med Source Type: research

The COX2/PGE2 Pathway Maintains Senescence of Chronic Obstructive Pulmonary Disease Fibroblasts.
Conclusion. PGE2 is a critical component of an amplifying and self-perpetuating circle inducing senescence and inflammation in COPD fibroblasts. Modulating the described PGE2 signaling pathway could provide new basis to dampen senescence and senescence-associated inflammation in COPD. PMID: 23328527 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Dagouassat M, Gagliolo JM, Chrusciel S, Bourin MC, Duprez C, Caramelle P, Boyer L, Hue S, Stern JB, Validire P, Longrois D, Norel X, Dubois-Randé JL, Le Gouvello S, Adnot S, Boczkowski J Tags: Am J Respir Crit Care Med Source Type: research

ADCYAP1R1 and Asthma in Puerto Rican Children.
CONCLUSIONS: Epigenetic and genetic variants in ADCYAP1R1 are associated with asthma in Puerto Rican children. PMID: 23328528 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Chen W, Boutaoui N, Brehm JM, Han YY, Schmitz C, Cressley A, Acosta-Pérez E, Alvarez M, Colón-Semidey A, Baccarelli AA, Weeks DE, Kolls JK, Canino G, Celedón JC Tags: Am J Respir Crit Care Med Source Type: research

Plasma Angiopoietin-2 Predicts the Onset of Acute Lung Injury in Critically Ill Patients.
CONCLUSIONS: Plasma biomarkers such as Ang-2 can improve clinical prediction scores and identify patients at high risk for ALI. In addition, the early rise of Ang-2 emphasizes the importance of endothelial injury in the early pathogenesis of ALI. PMID: 23328529 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS Tags: Am J Respir Crit Care Med Source Type: research

Production of Serotonin by Tryptophan Hydroxylase 1 andRelease via Platelets Contribute to Allergic Airway Inflammation.
CONCLUSION: In summary, TPH1-deficiency or -inhibition reduces AAI. Platelet- and not mast cell-derived 5-HT is pivotal in AAI, and lack of 5-HT leads to an impaired Th2-priming capacity of BMDC. Thus, targeting TPH1 could offer novel therapeutic options for asthma. PMID: 23328530 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Paula Vieira R, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M Tags: Am J Respir Crit Care Med Source Type: research

Interaction Between Pseudomonas and CXC Chemokines Increases Risk of BOS and Death in Lung Transplantation.
Conclusions Our model demonstrates that common post-transplantation events drive movement from one post-transplantation State to another and influence outcomes differently dependent upon when after transplantation they occur. Furthermore, pseudomonas and the ELR+ CXC chemokines may interact to negatively influence lung transplant outcomes. PMID: 23328531 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Gregson AL, Wang X, Weigt SS, Palchevskiy V, Lynch JP, Ross DJ, Kubak BM, Saggar R, Fishbein MC, Ardehali A, Li G, Elashoff R, Belperio JA Tags: Am J Respir Crit Care Med Source Type: research

Mitochondrial abnormalities in temporal lobe of autistic brain.
Abstract Autism spectrum disorder (ASD) consists of a group of complex developmental disabilities characterized by impaired social interactions, deficits in communication and repetitive behavior. Multiple lines of evidence implicate mitochondrial dysfunction in ASD. In postmortem BA21 temporal cortex, a region that exhibits synaptic pathology in ASD, we found that compared to controls, ASD patients exhibited altered protein levels of mitochondria respiratory chain protein complexes, decreased Complex I and IV activities, decreased mitochondrial antioxidant enzyme SOD2, and greater oxidative DNA damage. Mitochondria...
Source: Neurobiology of Disease - January 17, 2013 Category: Neurology Authors: Tang G, Gutierrez Rios P, Kuo SH, Akman O, Rosoklija G, Tanji K, Dwork A, Schon EA, Dimauro S, Goldman J, Sulzer D Tags: Neurobiol Dis Source Type: research

Tissue Artifact Removal from Respiratory Signals Based on Empirical Mode Decomposition.
Abstract On-line measurement of respiration plays an important role in monitoring human physical activities. Such measurement commonly employs sensing belts secured around the rib cage and abdomen of the test object. Affected by the movement of body tissues, respiratory signals typically have a low signal-to-noise ratio. Removing tissue artifacts therefore is critical to ensuring effective respiration analysis. This paper presents a signal decomposition technique for tissue artifact removal from respiratory signals, based on the empirical mode decomposition (EMD). An algorithm based on the mutual information and po...
Source: Annals of Biomedical Engineering - January 17, 2013 Category: Biomedical Engineering Authors: Liu S, Gao RX, John D, Staudenmayer J, Freedson P Tags: Ann Biomed Eng Source Type: research

The Neutrophil in COPD: Too Little Too Late, or Too Much Too Soon?
Abstract COPD (chronic obstructive pulmonary disease) is the fourth leading cause of death worldwide, and has few effective therapies. It is characterized by anomalous and persistent inflammation, both local and systemic. Neutrophilic inflammation predominates in the COPD airway wall and lumen, but despite the presence of abundant innate immune cells the progressive clinical course of the disease is punctuated by recurrent infection-driven exacerbations. An extensive body of evidence (from cell culture to murine models and finally to the susceptibility of human patients with α1-antitrypsin deficiency to develop CO...
Source: American Journal of Respiratory Cell and Molecular Biology - January 17, 2013 Category: Molecular Biology Authors: Hoenderdos K, Condliffe A Tags: Am J Respir Cell Mol Biol Source Type: research

Targeting GSK-3ss to Prevent Hyperoxia-Induced Lung Injury in Neonatal Rats.
Abstract The pathological hallmarks of bronchopulmonary dysplasia (BPD), a chronic lung disease of premature infants, include inflammation, arrested alveolarization and dysregulated angiogenesis. Severe BPD is often complicated by pulmonary hypertension (PH) that significantly increases morbidity and mortality. Glycogen synthase kinase-3 beta (GSK-3β) plays a pivotal role in embryonic development, cell proliferation and survival, and inflammation by modulating multiple signaling pathways, particularly the nuclear transcription factor NF-ĸB and Wnt/ß-catenin pathways. Aberrant GSK-3ß signaling is linked to BPD. ...
Source: American Journal of Respiratory Cell and Molecular Biology - January 17, 2013 Category: Molecular Biology Authors: Hummler SC, Rong M, Chen S, Hehre D, Alapati D, Wu S Tags: Am J Respir Cell Mol Biol Source Type: research

Hemozoin Induces Lung Inflammation and Correlates with Malaria-Associated Acute Respiratory Distress Syndrome.
Abstract Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a deadly complication and its pathophysiology is insufficiently understood. Both in humans and mouse models, MA-ARDS is characterized by marked pulmonary inflammation. We investigated the role of hemozoin in MA-ARDS in C57Bl/6 mice infected with P. berghei NK65, P. berghei ANKA and P. chabaudi AS. By quantifying hemozoin in the lungs and measuring disease parameters of MA-ARDS, we demonstrate a highly significant correlation between pulmonary hemozoin levels, lung weight and alveolar edema. Histological analysis of the lungs demonstrated t...
Source: American Journal of Respiratory Cell and Molecular Biology - January 17, 2013 Category: Molecular Biology Authors: Deroost K, Tyberghein A, Lays N, Noppen S, Schwarzer E, Vanstreels E, Komuta M, Prato M, Lin JW, Pamplona A, Janse CJ, Arese P, Roskams T, Daelemans D, Opdenakker G, Van den Steen PE Tags: Am J Respir Cell Mol Biol Source Type: research

Recombinant equine herpes virus 1 (EHV-1) vaccine protects pigs against challenge with influenza A(H1N1)pmd09.
Abstract Swine influenza virus (SIV) is not only an important respiratory pathogen in pigs but also a threat to human health. The pandemic influenza A(H1N1)pdm09 virus likely originated in swine through reassortment between a North American triple reassortant and Eurasian avian-like SIV. The North American triple reassortant virus has genes from avian, human and swine influenza viruses. An effective vaccine may protect the pork industry from economic losses and curb the development of new virus variants that may threaten public health. In the present study, we evaluated the efficacy of a recombinant equine herpesvi...
Source: Virus Research - January 17, 2013 Category: Virology Authors: Said A, Lange E, Beer M, Damiani A, Osterrieder N Tags: Virus Res Source Type: research

Genetic analysis of the VP4/VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan.
Abstract We performed detailed genetic analysis of the VP4/VP2 coding region in human rhinovirus species C (HRV-C) strains detected in patients with acute respiratory infection in Japan. Phylogenetic trees were constructed by the neighbor joining (NJ) and maximum likelihood (ML) methods. An NJ phylogenetic tree assigned 11 genotypes to the present strains. An ML tree showed that the strains diversified sometime in the early 1870s. Moreover, the pairwise distance among the present strains was relatively long, and the rate of molecular evolution of the coding region was rapid (3.07 × 10-3 substitutions/site/year). T...
Source: Journal of Medical Microbiology - January 17, 2013 Category: Microbiology Authors: Kiyota N, Kushibuchi I, Kobayashi M, Tsukagoshi H, Ryo A, Nishimura K, Hirata-Saito A, Harada S, Arakawa M, Kozawa K, Noda M, Kimura H Tags: J Med Microbiol Source Type: research

Comparative pharmacokinetic profiles of picroside I and II from kutkin, Picrorhiza kurroa extract and its formulation in rats.
This study attempts to determine the in vivo pharmacokinetic profile of picroside I and II in rats after oral administration of three different preparations namely, kutkin (a mixture of picroside I and II), P. kurroa extract and Picrolax® capsule (marketed formulation). A simple, precise, specific and sensitive method was developed for simultaneous quantification of picroside I and II in rat plasma and was applied for the pharmacokinetic study. Pharmacokinetic parameters were calculated from the observed plasma concentration of picroside I and II. The results showed a significant difference (p≤0.05) in oral bioavailabil...
Source: Fitoterapia - January 17, 2013 Category: Biochemistry Authors: Upadhyay D, Dash RP, Anandjiwala S, Nivsarkar M Tags: Fitoterapia Source Type: research

St. George's Respiratory Questionnaire has Longitudinal Construct Validity in Lymphangioleiomyomatosis*
CONCLUSIONS: In LAM, SGRQ scores are associated with variables used to assess LAM severity. The SGRQ is sensitive to change in LAM severity, particularly when change is defined by FEV1, perhaps the most clinically relevant and prognostically important variable in LAM. The constellation of results here support the validity of the SGRQ as capable of assessing longitudinal change in HRQL in LAM. PMID: 23328755 [PubMed - as supplied by publisher]
Source: Chest - January 17, 2013 Category: Respiratory Medicine Authors: Swigris JJ, Lee HS, Cohen M, Inoue Y, Moss J, Singer L, Young LR, McCormack FX Tags: Chest Source Type: research

Implications for Human Leukocyte Antigen Antibodies after Lung Transplantation: A 10 year experience in 441 patients.
CONCLUSIONS: Approximately one-third of lung transplant recipients have detectable HLA antibodies which is associated with a worse prognosis with regards to graft function and patient survival. PMID: 23328795 [PubMed - as supplied by publisher]
Source: Chest - January 17, 2013 Category: Respiratory Medicine Authors: Snyder LD, Wang Z, Chen DF, Reinsmoen NL, Finlen Copeland CA, Davis WA, Zaas DW, Palmer SM Tags: Chest Source Type: research

Endothelial Dysfunction In Children With Obstructive Sleep Apnea Is Associated With Epigenetic Changes in the eNOS Gene.
CONCLUSIONS: The presence of abnormal eNOS-dependent vascular responses in children with OSA is associated with epigenetic modifications in the eNOS gene. PMID: 23328840 [PubMed - as supplied by publisher]
Source: Chest - January 17, 2013 Category: Respiratory Medicine Authors: Kheirandish-Gozal L, Khalyfa A, Gozal D, Bhattacharjee R, Wang Y Tags: Chest Source Type: research

Cryoprobe Transbronchial Lung Biopsy in Lung Transplant Patients: A Safety Pilot.
CONCLUSION: The use of the cryoprobe is a safe alternative technique to transbronchial forceps biopsy during post-lung transplant bronchoscopy. Further studies are needed to determine if larger samples obtained with CPBx translate to an increased diagnostic yield. PMID: 23328889 [PubMed - as supplied by publisher]
Source: Chest - January 17, 2013 Category: Respiratory Medicine Authors: Yarmus L, Akulian J, Gilbert C, Illei P, Shah P, Merlo C, Orens J, Feller-Kopman D Tags: Chest Source Type: research

Predictors of outcome in patients with cystic fibrosis requiring endotracheal intubation
ConclusionsPatients with CF developing haemoptysis and/or pneumothorax should be admitted to ICU and intubated promptly should this be required. Chronic disease markers may be more relevant prognostically than rates of hospitalisation or FEV1 decline which should not be bars to invasive ventilation.
Source: Respirology - January 17, 2013 Category: Respiratory Medicine Authors: Andrew Jones, Diana Bilton, Timothy W Evans, Simon J Finney Tags: Original Article Source Type: research

Volume rather than flow incentive spirometry is effective in improving chest wall expansion and abdominal displacement using optoelectronic plethysmography.
Conclusion:Our results demonstrate that the VIS promotes a greater increase in the chest wall volume with a larger abdominal contribution and lower respiratory muscular activity than the FIS in healthy adults. PMID: 23258579 [PubMed - as supplied by publisher]
Source: Respiratory Care - January 17, 2013 Category: Respiratory Medicine Authors: Paisani DD, Lunardi AC, Marques da Silva CC, Porras DC, Tanaka C, Carvalho CR Tags: Respir Care Source Type: research

Health-care utilization and respiratory morbidities in preterm infants with pulmonary hypertension
& J M Collaco
Source: Journal of Perinatology - January 17, 2013 Category: Perinatology & Neonatology Authors: B D StuartP SekarJ D CoulsonS E J ChoiS A McGrath-MorrowJ M Collaco Tags: bronchopulmonary dysplasia chronic lung disease prematurity pulmonary hypertension Source Type: research

Screening and treating pulmonary arterial hypertension in a tertiary hospital‐based multidisciplinary clinic: the first 200 patients
ConclusionA multidisciplinary clinic can provide efficient diagnosis and rapid triage to PAH‐specific therapy, if appropriate. Retention rates remain high, at follow up.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: A. J. Low, D. Fowler, M. K. Manghani, I. Young, R. Garsia, P. Torzillo, P. Youssef, D. S. Celermajer Tags: Original Article Source Type: research

Ranitidine use is associated with increased morbidity and mortality in very low birthweight infants
Commentary on: Terrin G, Passariello A, De Curtis M, et al.. Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns. Pediatrics 2012;129:e40–5. Context Gastroesophageal reflux (GER) is the retrograde movement of stomach contents into the oesophagus. Pharmacotherapy aimed at reducing problems attributed to GER includes histamine receptor blockers (H2 blockers), such as ranitidine, which reduce stomach acidity. Extremely preterm infants often exhibit clinical signs consistent with GER,1 and GER medications are among the most commonly prescribed medications in neonatal intensi...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Cotten, C. M., Malcolm, W. F. Tags: EBM Aetiology, Oesophagus, Epidemiologic studies, Stomach and duodenum, Pneumonia (infectious disease), Urinary tract infections, Drugs: CNS (not psychiatric), Pneumonia (respiratory medicine), Vulvovaginal disorders, Urinary tract infections Source Type: research

Occupational allergic rhinoconjunctivitis and bronchial asthma induced by goat cheese
Occupational asthma represents 25% of cases of occupational lung disease and 5–10% of cases of asthma in adults.1 A 49-year-old woman developed rhinoconjunctivitis and bronchial asthma related with the production of goat cheese, in a cheese factory. She was in charge of the cheese production process three days a week, and she had episodes of coughing, sneezing, rhinorrea, watery eyes, wheezing and dyspnoea, for 2 years. Symptoms decreased during the cheeses packing process and disappeared during holidays and weekends, suggesting an occupational exposure. She tolerated eating goat cheese. The patient had a normal...
Source: Occupational and Environmental Medicine - January 17, 2013 Category: Occupational Health Authors: Sastre, I., Rodriguez-Perez, R., Garcia, F., Juste, S., Moneo, I., Caballero, M. L. Tags: PostScript Source Type: research

Pattern and predictors for respiratory illnesses and symptoms and lung function among textile workers in Karachi, Pakistan
Conclusions This study highlights the burden of respiratory illnesses and symptoms, and a low prevalence of asthma among textile workers in Karachi. Work in the spinning section, lack of education, prolonged duration of work and Sindhi ethnicity, were identified as important risk factors.
Source: Occupational and Environmental Medicine - January 17, 2013 Category: Occupational Health Authors: Nafees, A. A., Fatmi, Z., Kadir, M. M., Sathiakumar, N. Tags: Respiratory Workplace Source Type: research

Low plasma citrulline levels are associated with acute respiratory distress syndrome in patients with severe sepsis
Conclusions: In severe sepsis, levels of the NOS substrate citrulline are low and are associated with ARDS. Low NOS substrate levels have been shown in other disease states to lead to NOS uncoupling and oxidative injury suggesting a potential mechanism for the association between low citrulline and ARDS. Further studies are needed to determine whether citrulline supplementation could prevent the development of ARDS in patients with severe sepsis and to determine its role in NOS coupling and function.
Source: Critical Care - January 17, 2013 Category: Intensive Care Authors: Lorraine WareJordan MagarikNancy WickershamGary CunninghamTodd RiceBrian ChristmanArthur WheelerGordon BernardMarshall Summar Source Type: research

Serum amyloid P inhibits granulocyte adhesion
Conclusions: We found that SAP, a constitutive component of blood, is a granulocyte adhesion inhibitor. We hypothesize that SAP allows granulocytes to sense whether they are in the blood or in a tissue.
Source: Fibrogenesis and Tissue Repair - January 17, 2013 Category: Biomedical Science Authors: Anu MaharjanDavid RoifeDerrick BrazillRichard Gomer Source Type: research

Cardiovascular and Noncardiovascular Disease Associations with Hip Fractures
Conclusions: Although the association with hip fracture was not specific to cardiovascular disease, temporal increases were mainly detected in cardiometabolic diseases, all of which have been linked previously to frailty. This mechanism and others warrant further investigation.
Source: The American Journal of Medicine - January 16, 2013 Category: Journals (General) Authors: Yariv Gerber, L. Joseph Melton, Sheila M. McNallan, Ruoxiang Jiang, Susan A. Weston, Véronique L. Roger Tags: Clinical research studies Source Type: research

Coughs Fool Patients into Unnecessary Requests for Antibiotics
[caption id="attachment_10667" align="alignleft" width="320" caption="Image courtesy of iStockphoto/drbimages"] [/caption]No one wants a hacking cough for days or weeks on end . But research shows that it generally takes about 18 days to get over a standard cough-based illness. Most of us grow impatient after a week or so and head to the doctor to get a prescription . The problem with that recourse, however, is that antibiotics are usually useless against typical respiratory infections that cause coughs. [More]
Source: Scientific American - Official RSS Feed - January 16, 2013 Category: Science Tags: Health,More Science,Mind & Brain Source Type: research

Respiratory syncytial virus infection and recurrent wheezing in Chilean infants: A genetic background?
CONCLUSION: Genetic variations in the host are associated to infection severity and outcome. A common genetic background might be influencing both pathologies. PMID: 23333336 [PubMed - as supplied by publisher]
Source: Infection, Genetics and Evolution - January 16, 2013 Category: Genetics & Stem Cells Authors: Tapia LI, Ampuero S, Palomino MA, Luchsinger V, Aguilar N, Ayarza E, Mamani R, Larrañaga C Tags: Infect Genet Evol Source Type: research

Gastroesophageal Reflux Disease in Neonates and Infants : When and How to Treat.
Abstract Gastroesophageal reflux (GER) is defined as the involuntary retrograde passage of gastric contents into the esophagus with or without regurgitation or vomiting. It is a frequently experienced physiologic condition occurring several times a day, mostly postprandial and causes no symptoms. These infants are also called 'happy spitters'. GER disease (GERD) occurs when reflux of the gastric contents causes symptoms that affect the quality of life or pathologic complications, such as failure to thrive, feeding or sleeping problems, chronic respiratory disorders, esophagitis, hematemesis, apnea, and apparent lif...
Source: Paediatric Drugs - January 16, 2013 Category: Pediatrics Authors: Czinn SJ, Blanchard S Tags: Paediatr Drugs Source Type: research