Respiratory Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 24.

Scopolamine bultybromide/tramadol: Respiratory depression in a neonate following in utero exposure: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Paracetamol: Pancreatitis, acute respiratory distress syndrome and metabolic acidosis: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Mepivacaine: Motor paralysis, respiratory depression and various toxicities: 9 case reports
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Iobenguane: Acute respiratory distress syndrome?: 5 case reports
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Ibogaine: Respiratory insufficiency (first report), torsade de pointes and QT interval prolongation: 2 case reports
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Gemcitabine: Acute respiratory distress syndrome: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Baclofen overdose: Deep coma and respiratory depression: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Amiodarone: Pulmonary pneumonitis causing acute respiratory distress syndrome in an elderly patient: case report
Source: Reactions - January 12, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Lung tissue bioenergetics and caspase activity in rodents
This study aimed to establish a suitable in vitro system for investigating effects of respiratory pathogens and toxins on lung tissue bioenergetics (cellular respiration and ATP content) and caspase activity. Wistar rats and C57Bl/6 mice were anesthetized by sevoflurane inhalation. Lung fragments were then collected and incubated at 37oC in a continuously gassed (with 95% O2:5% CO2) Minimal Essential Medium (MEM) or Krebs-Henseleit buffer. Phosphorescence O2 analyzer that measured dissolved O2 concentration as a function of time was used to monitor the rate of cellular mitochondrial O2 consumption. Cellular ATP content was...
Source: BMC Research Notes - January 12, 2013 Category: Research Authors: Ahmed AlsuwaidiMohammed AlsamriAli AlfazariSaeeda AlmarzooqiAlia AlbawardiAws OthmanThachillath PramathanStacey HartwigSteven VargaAbdul-Kader Souid Source Type: research

Derangements of liver tissue bioenergetics in Concanavalin A-induced hepatitis
This study aimed to investigate hepatocyte bioenergetics in this well-studied hepatitis model. Methods: C57Bl/6 and C57Bl/6 IFN-gamma-/- mice were injected intravenously with 12 mg ConA/kg. Liver specimens were collected at various timepoints after injection and analyzed for cellular respiration and caspase activation. Serum was analyzed for interferon-gamma (IFN-gamma) and aminotransferases. Fluorescence activated cell sorting analysis was used to determine the phenotype of infiltrating cells, and light and electron microscopy were used to monitor morphological changes. Phosphorescence analyzer that measured dissolved O2 ...
Source: BMC Gastroenterology - January 12, 2013 Category: Gastroenterology Authors: Mariam Al-ShamsiAllen ShahinEric Mensah-BrownAbdul-Kader Souid Source Type: research

Heparin – binding protein (HBP) in critically ill patients with influenza A(H1N1) infection
Abstract Heparin‐Binding Protein (HBP) is an inducer of vascular endothelial leakage in severe infections. Fluid accumulation into alveoli is a general finding in acute respiratory distress syndrome (ARDS). Severe acute respiratory failure with ARDS is a complication of influenza A(H1N1) infection. Accordingly, we studied the HBP levels in critically ill patients with infection of influenza A(H1N1).Critically ill patients in four intensive care units (ICU) with polymerase chain reaction (PCR) confirmed infection of influenza A(H1N1) were prospectively evaluated. We collected clinical data and blood samples at ICU admissi...
Source: Clinical Microbiology and Infection - January 12, 2013 Category: Microbiology Authors: Kirsi‐Maija Kaukonen, Rita Linko, Heiko Herwald, Lennart Lindbom, Esko Ruokonen, Tero Ala‐Kokko, Ville Pettilä Tags: Original Article Source Type: research

Mycobacterium tuberculosis Whole Cell Lysate Enhances Proliferation of CD8 Positive Lymphocytes and Nitric Oxide Secretion in the Lungs of Live Porcine Respiratory and Reproductive Syndrome Virus Vaccinated Pigs
Viral Immunology , Vol. 0, No. 0.
Source: Viral Immunology - January 11, 2013 Category: Allergy & Immunology Tags: article Source Type: research

Role of Wild Small Ruminants in the Epidemiology of Peste Des Petits Ruminants
Summary Peste des petits ruminants virus (PPRV) causes one of the most contagious and highly infectious respiratory diseases in sheep and goats known as peste des petits ruminants (PPR). Reports of outbreaks of PPR in captive and wild small ruminants have extended the known spectrum of susceptible species to include antelopes. Phylogenetic analysis of nucleoprotein and fusion genes indicates that all PPRVs isolated from wild ungulate outbreaks belong to lineage IV. While it is clear that a number of wildlife species are susceptible to infection, the role of wildlife in the epidemiology of PPR remains uncertain. The availab...
Source: Transboundary and Emerging Diseases - January 11, 2013 Category: Veterinary Research Authors: M. Munir Tags: Review Source Type: research

Designs of optimized microbial therapy systems of respiratory infections.
Abstract Several respiratory infections are frequently induced by pathogenic microorganisms in lung epithelial lining fluid (ELF) and alveolar macrophages (AM). Then, two studies concerning designs of antimicrobial therapy systems of respiratory infections were carried out; one was the distribution mechanisms of three macrolide and ketolide antibiotics, clarithromycin (CAM), azithromycin (AZM) and telithromycin (TEL) in plasma, ELF and AM, and the other was the efficient drug delivery to AM by pulmonary administration of fluoroquinolone antibiotic, a ciprofloxacin (CPFX) incorporated into liposomes (CPFX-liposome)....
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 11, 2013 Category: Drugs & Pharmacology Authors: Morimoto K Tags: Yakugaku Zasshi Source Type: research

Pharyngo-laryngoscopic video-recording in obstructive sleep apnea during natural N2 sleep. A case report of a non-complete obstructive mechanism
Conclusions: This case highlights that OSA could not be as obstructive as generally thought, at least during N2 sleep; moreover, it suggests that apneic episodes are not a totally passive and monomorphic phenomenon, but a rather complex event.
Source: Sleep Medicine - January 11, 2013 Category: Sleep Medicine Authors: Jorge Iriarte, Jose-Alberto Palma, Secundino Fernandez, Elena Urrestarazu, Manuel Alegre, Julio Artieda, Peter Baptista Tags: Video-Clinical Corners Source Type: research

The Anticancer Drug Tamoxifen Counteracts the Pathology in a Mouse Model of Duchenne Muscular Dystrophy.
Abstract Duchenne muscular dystrophy (DMD) is a severe disorder characterized by progressive muscle wasting, respiratory and cardiac impairments, and premature death. No treatment exists so far, and the identification of active substances to fight DMD is urgently needed. We found that tamoxifen, a drug used to treat estrogen-dependent breast cancer, caused remarkable improvements of muscle force and of diaphragm and cardiac structure in the mdx(5Cv) mouse model of DMD. Oral tamoxifen treatment from 3 weeks of age for 15 months at a dose of 10 mg/kg/day stabilized myofiber membranes, normalized whole body force, an...
Source: The American Journal of Pathology - January 11, 2013 Category: Pathology Authors: Dorchies OM, Reutenauer-Patte J, Dahmane E, Ismail HM, Petermann O, Patthey-Vuadens O, Comyn SA, Gayi E, Piacenza T, Handa RJ, Décosterd LA, Ruegg UT Tags: Am J Pathol Source Type: research

Gramella aestuarii sp. nov. isolated from tidal flat and emended description of Gramella echinicola Nedashkovskaya et al. 2005.
Abstract A Gram-staining-negative, yellow-pigmented, strictly aerobic, motile bacterium by gliding, designated BS12T, was isolated from a tidal flat at Boseong, Korea. Cells were moderately halotolerant, catalase- and oxidase-positive rods. Growth was observed at 5-40 °C (optimum, 25 °C), at pH 5.5-9.0 (optimum, pH 7.0-7.5) and in the presence of 1-11% (w/v) NaCl (optimum, 2-4%). The major cellular fatty acids were iso-C15:0, iso-C17:0 3-OH, iso-C17:1 ω9c and anteiso-C15:0. The polar lipid pattern was comprised of phosphatidylethanolamine, four unidentified aminolipids and three unidentified lipids. The G+C cont...
Source: International Journal of Systematic and Evolutionary Microbiology - January 11, 2013 Category: Microbiology Authors: Jeong SH, Jin HM, Jeon CO Tags: Int J Syst Evol Microbiol Source Type: research

Cohnella formosensis sp. nov., a xylanolytic bacterium isolated from the rhizosphere of Medicago sativa L.
Abstract A Gram-positive, spore-forming, aerobic, rod-shaped, xylanolytic bacterium designated as strain CC-Alfalfa-35T was isolated from the rhizosphere of Medicago sativa L. in Taiwan. The phylogenetic analysis based on 16S rRNA gene sequence showed that the strain CC-Alfalfa-35T was affiliated to the genus Cohnella. Strain CC-Alfalfa-35T shared 95.3 % pairwise 16S rRNA gene sequence similarity to the type species of the genus Cohnella (C. thermotolerans DSM 17683T) besides showing a similarity of 97.4-93.6 % with other validly published Cohnella species. DNA-DNA hybridization value between CC-Alfalfa-35T and C....
Source: International Journal of Systematic and Evolutionary Microbiology - January 11, 2013 Category: Microbiology Authors: Hameed A, Hung MH, Lin SY, Hsu YH, Liu YC, Shahina M, Lai WA, Huang HC, Young LS, Young CC Tags: Int J Syst Evol Microbiol Source Type: research

Chryseobacterium kwangjuense sp. nov., isolated from pepper (Capsicum annuum L.) root.
Abstract The yellow-pigmented, Gram-negative, rod-shaped bacterium KJ1R5T was isolated from the root of a pepper plant grown in a field in Kwangju, Korea. Strain KJ1R5T was characterized by physiological, biochemical, and molecular genetic analyses. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain KJ1R5T was most closely related to members of the genus Chryseobacterium, and that the strain exhibited the highest similarities with type strains of Chryseobacterium vrystaatense (97.0 %) and Chryseobacterium rhizosphaerae (97.1 %). DNA-DNA hybridization reassociation values between strain KJ1R5T...
Source: International Journal of Systematic and Evolutionary Microbiology - January 11, 2013 Category: Microbiology Authors: Sang MK, Kim HS, Myung IS, Ryu CM, Kim BS, Kim KD Tags: Int J Syst Evol Microbiol Source Type: research

Arenitalea lutea gen. nov., sp. nov., a marine bacterium of the family Flavobacteriaceae isolated from intertidal sand of Yellow Sea, China.
Abstract A yellow-colored, rod-shaped, Gram-negative and facultatively aerobic gliding bacterium, designed strain P7-3-5T, was isolated from intertidal sand of Yellow Sea, China. Analysis of 16S rRNA gene sequences revealed that strain P7-3-5T formed a distinct lineage within the family Flavobacteriaceae, sharing 94.2-96.9% sequence similarities with type strains of the most closely related genera including Hyunsoonleella, Jejuia, Marinivirga and Algibacter. The strain grew at 4-40°C and with 0.5-5.0% (w/v) NaCl. It reduced nitrate to nitrite and hydrolyzed gelatin and DNA. The major cellular fatty acids were iso-...
Source: International Journal of Systematic and Evolutionary Microbiology - January 11, 2013 Category: Microbiology Authors: Zhang XY, Liu A, Liu C, Li H, Li GW, Xu Z, Chen XL, Zhou BC, Zhang YZ Tags: Int J Syst Evol Microbiol Source Type: research

Flavobacterium cutihirudinis sp. nov., isolated from Hirudo verbana.
Abstract A Gram-staining-negative, non-endospore-forming, yellow pigmented strain (E89T) was isolated from the skin of the medical leech Hirudo verbana obtained from the leech farm located in Biebertal, Germany. 16S rRNA gene sequencing analysis showed that the isolate was grouped into the genus Flavobacterium. Strain E89T was most closely related to the type strains of Flavobacterium chilense (98.2%), Flavobacterium chungangense (98.1%), and 'Flavobacterium oncorhynchi' (98.1%). To all other Flavobacterium species 16S rRNA gene sequence similarities were ≤ 97.4%. A menaquinone from the type MK-6 was found to be ...
Source: International Journal of Systematic and Evolutionary Microbiology - January 11, 2013 Category: Microbiology Authors: Glaeser SP, Galatis H, Martin K, Kämpfer P Tags: Int J Syst Evol Microbiol Source Type: research

Sens-it-iv: a European Union project to develop novel tools for the identification of skin and respiratory sensitizers.
PMID: 23318727 [PubMed - as supplied by publisher]
Source: Toxicology in Vitro - January 11, 2013 Category: Toxicology Authors: Roggen EL, Blaauboer BJ Tags: Toxicol In Vitro Source Type: research

Lung Cancer Screening With Low-Dose Computed Tomography After the National Lung Screening Trial. The Debate is Still Open.
Abstract The aim of this article is to highlight some concerns regarding lung cancer screening with CT through a thorough analysis of scientific literature. The publication of the National Lung Screening Trial in 2011 has revealed that CT screening of smokers and ex-smokers in three annual rounds reduces lung cancer mortality a 20% when compared with thorax x-ray screening. The first limitation of this screening modality is its lack of downstaging in successive screening rounds compared with the initial round. Also, lung cancer screening with CT has a low positive predictive value, similar to the percentage of unne...
Source: Archivos de Bronconeumologia - January 11, 2013 Category: Respiratory Medicine Authors: Ruano-Ravina A, Pérez Ríos M, Fernández-Villar A Tags: Arch Bronconeumol Source Type: research

Underdiagnosis of Chronic Obstructive Pulmonary Disease in Women: Quantification of the Problem, Determinants and Proposed Actions.
CONCLUSIONS: There is a greater underdiagnosis of COPD in women than in men in Spain. PMID: 23317767 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - January 11, 2013 Category: Respiratory Medicine Authors: Ancochea J, Miravitlles M, García-Río F, Muñoz L, Sánchez G, Sobradillo V, Duran-Tauleria E, Soriano JB Tags: Arch Bronconeumol Source Type: research

Hypersensitivity Pneumonitis Due to Exposure to Mycobacterium avium.
PMID: 23317768 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - January 11, 2013 Category: Respiratory Medicine Authors: Terrero Jiménez BM, Abad Fernández A, Juretschke Moragues MA Tags: Arch Bronconeumol Source Type: research

Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats.
In conclusion, we suggest that TER improves mitochondrial function but does not reduce oxidative stress, muscle damage, or inflammation induced by eccentric contractions. PMID: 23314343 [PubMed - as supplied by publisher]
Source: Braz J Med Biol Res - January 11, 2013 Category: Research Authors: Silva LA, Bom KF, Tromm CB, Rosa GL, Mariano I, Pozzi BG, Tuon T, Stresck EL, Souza CT, Pinho RA Tags: Braz J Med Biol Res Source Type: research

Effects of transcutaneous electrical nerve stimulation on pain, walking function, respiratory muscle strength and vital capacity in kidney donors: a protocol of a randomized controlled trial
This study is the first to examine the effects of TENS in this population. TENS during the postoperative period may result in pain relief and improvements in pulmonary tests and mobility, thus leading to an improved quality of life and further promoting organ donation.Trial registration: Registro Brasileiro de Ensaios Clinicos (ReBEC), number RBR-8xtkjp.
Source: BMC Nephrology - January 11, 2013 Category: Urology & Nephrology Authors: Thiago GalliLuciana ChiavegatoNathália SantiagoRichard Liebano Source Type: research

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study
Conclusion: Our data demonstrate that recipients of an allogeneic HSCT experience an increase in biomarkers of pulmonary inflammation and a decrease in lung function in the first six months after the procedure. If independently validated in other study populations, these observations could have potential as a prognostic biomarker for this patient group.
Source: BMC Pulmonary Medicine - Latest articles - January 11, 2013 Category: Respiratory Medicine Authors: Alexandra EnocsonRichard HubbardTricia McKeeverNigel RussellJennifer ByrneEmma Das-GuptaLynne WatsonAndrew Fogarty Source Type: research

Evaluation of a IS6110‐Taqman real‐time PCR assay to detect Mycobacterium tuberculosis in sputum samples of patients with pulmonary TB
ConclusionsThe IS6110‐TaqMan was rapid, sensitive and specific for the diagnosis of pulmonary TB. Significance and Impact of the StudyIS6110‐TaqMan assay is a promising auxiliary tool for the diagnosis of pulmonary TB when used in conjunction with routine laboratory tests, clinical and epidemiological criteria of the patient, thus increasing the sensitivity and specificity of diagnosis.
Source: Journal of Applied Microbiology - January 11, 2013 Category: Microbiology Authors: L.A.S. Lira, F.C.F. Santos, M.S.Z. Carvalho, R.A. Montenegro, J.F.C. Lima, H.C. Schindler, L.M.L. Montenegro Tags: Original Article Source Type: research

Analytical validation of a novel high multiplexing real-time PCR array for the identification of key pathogens causative of bacterial ventilator-associated pneumonia and their associated resistance genes
Conclusions VAPChip is a novel diagnostic tool able to identify resistant bacterial isolates by RAP-ID technology. The results of this analytical validation have to be confirmed on clinical specimens.
Source: Journal of Antimicrobial Chemotherapy - January 11, 2013 Category: Microbiology Authors: Bogaerts, P., Hamels, S., de Mendonca, R., Huang, T.- D., Roisin, S., Remacle, J., Markine-Goriaynoff, N., de Longueville, F., Pluster, W., Denis, O., Glupczynski, Y. Tags: Original research Source Type: research

Extracorporeal Life Support Experiences of a New Congenital Heart Center in Turkey
Abstract Extracorporeal life support (ECLS) provides mechanical support following cardiac surgery when respiratory and cardiac failure occurs. We retrospectively reviewed medical records of patients who needed ECLS at a new congenital heart center in Turkey. Between December 2009 and February 2012, 616 congenital heart operations were performed. A total of 13 patients (seven female) underwent ECLS. The ages of the patients ranged between 16 days and 33 years. There were two neonatal, seven infant, three pediatric, and one adult congenital cases. Medos DPII ECLS system was used in all patients. Mean duration of ECLS was 6.2...
Source: Artificial Organs - January 11, 2013 Category: Transplant Surgery Authors: Ersin Erek, Sertac Haydin, Burak Onan, Ismihan Selen Onan, Pinar Yazici, Ozgen Kocyigit, Cansaran Tanidir, Perihan Yivli, Ender Odemis, Mehmet Yeniterzi, Ihsan Bakir Tags: Main Text Article Source Type: research

Pediatric Single‐Lumen Cannula Venovenous Extracorporeal Membrane Oxygenation: A French Center Experience
This article details a technical note and a retrospective analysis of our experience in refractory hypoxemia. The retrospective study, from 2007 to 2011, included all pediatric and neonatal patients treated by single‐lumen cannula VV ECMO. The study was focused on pre‐ECMO patient characteristics and complications during ECMO course. During the last 5 years, 67 pediatric patients were assisted by this single‐lumen cannula VV ECMO. Sixty‐one patients (91%) were newborns. Thirty‐nine patients presented with meconium aspiration syndrome (58%), which was the most frequent etiology. Before cannulation, mean oxygenatio...
Source: Artificial Organs - January 11, 2013 Category: Transplant Surgery Authors: Pierre‐Louis Léger, Julia Guilbert, Ségolène Isambert, Nolwenn Le Saché, Fazia Hallalel, Alain Amblard, Jean‐Yves Chevalier, Sylvain Renolleau Tags: Main Text Article Source Type: research

Food intake during the previous 24 h as a percentage of usual intake: a marker of hypoxia in infants with bronchiolitis: an observational, prospective, multicenter study
Conclusion: In practice, the measure of 24 h FI may be useful in identifying hypoxia and deserves further study.
Source: BMC Pediatrics - Latest articles - January 11, 2013 Category: Pediatrics Authors: François CorrardFrance de La RocqueElvira MartinClaudie WollnerAnnie ElbezMarc KoskasAlain WollnerMichel BoucheratRobert Cohen Source Type: research

Respiratory syncytial virus infection in infants and correlation with meteorological factors and air pollutants
Conclusions: RSV epidemic trend in Bologna (Italy) is related to the mean minimum temperature, and the mean PM10 concentration.
Source: Italian Journal of Pediatrics - January 11, 2013 Category: Pediatrics Authors: Silvia VandiniLuigi CorvagliaRosina AlessandroniGiulia AquilanoConcetta MarsicoMarica SpinelliMarcello LanariGiacomo Faldella Source Type: research

Scaffolding Effect of Vascular Distension on Peripheral Lung Mechanics
Pulmonary mechanics are an important component in the diagnosis and treatment of many respiratory disorders. Traditionally, mechanics measures have focused on the effects of airway hyper-responsiveness (asthma, reactive airway disease) and alterations to alveolar architecture (pulmonary fibrosis, COPD). However, a third component of the respiratory system, pulmonary blood flow, is rarely considered in interpreting mechanics measures. The forced oscillation technique uses impedance measurements to partition the respiratory system into central and peripheral components. We hypothesized that pulmonary blood flow contributes t...
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: B.C. Gibney, A.B. Ysasi, K. Chamoto, M. Ackermann, M.A. Konerding, A. Tsuda, S.J. Mentzer Tags: Oral Session: Thursday 2/7 7:30 AM to 9:30 AM Source Type: research

Banked Platelets Showed Decrease Mitochondrial Respiratory Capacities and Progressively Decrease Response to Activation
Hemorrhagic shock is one of the leading causes of death following severe trauma. In order to achieve hemodynamic stability and hemostasis, blood product transfusions including platelets are frequently necessary. Increased blood product storage time, however, may be associated with worse clinical outcomes. Here, we hypothesize that blood bank storage has a deleterious effect on platelet mitochondrial function as well as platelet activation.
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: J.P. Perales, Y. Guan, M. Selak, L.B. Becker, C. Sims Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

Obstructive Lung Disease Induced by Mesenchymal Specific Inhibition of Vascular Endothelial Growth Factor (VEGF)
Cronic obstructive pulmonary disease (COPD), asthma and bronchiectasis comprise a category of respiratory disease referred to as obstructive lung disease (OLD). COPD is the fifth leading cause of death in the USA and a common comorbidity among surgical patients. VEGF is an endothelial cell signal protein that is a key mediator of angiogenesis and vasculogenesis. Chronic blockade of the VEGF receptor (VEGFR) in an animal model has been shown to induce alveolar cell apoptosis resulting in emphysema and cigarette smoke has been demonstrated to interrupt the VEGF-VEGFR signaling complex in an animal model of COPD. Previous stu...
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: D.E. Levin, H. Xiaogang, S. Navarro, O. Garcia, J. Lee, B. Driscoll, T.C. Grikscheit Tags: Oral Session: Wednesday 2/6 7:30 AM to 9:30 AM Source Type: research

An Analysis of Outcomes Comparing Dual-Lumen Venovenous ECMO to Multi-Site Venovenous ECMO for Pediatric Respiratory Failure: The Extracorporeal Life Support Registry Experience
Source: Journal of Surgical Research - January 10, 2013 Category: Surgery Authors: I.J. Zamora, L. Shekerdemian, O.O. Olutoye, D.L. Cass, P. Rycus, C. Burgman, T.C. Lee Tags: Quickshot Session: Tuesday 2/5 7:30 AM to 9:30 AM Source Type: research

The association between personal care products and lung function
Conclusions: This study provides data suggesting that using personal care products may have a small adverse effect on lung function. Further research is warranted to investigate this possibility.
Source: Annals of Epidemiology - January 10, 2013 Category: Epidemiology Authors: Robert E. Dales, Sabit Cakmak, Judith Leech, Ling Liu Source Type: research

Editorial Board
Source: Respiratory Medicine CME - January 10, 2013 Category: Respiratory Medicine Source Type: research

Endothelin-Converting Enzyme-1 Gene Ablation Attenuates Pulmonary Fibrosis via CGRP-cAMP/EPAC1 Pathway.
Abstract Endothelin-1 (ET-1) has been shown to be involved in human pulmonary fibrosis. However, recent clinical trials targeting the ET-1 pathway with ET-1 receptor antagonists failed to achieve beneficial outcomes. Another strategy opposing the actions of ET-1 is the inhibition of endothelin-converting enzyme-1 (ECE-1). We hypothesize that ECE-1 inhibition has beneficial effects on pulmonary fibrosis. Pulmonary fibrosis was induced by instilling bleomycin intratracheally into ECE-1 heterozygous knock-out mice (ECE-1+/-) and their wild type (ECE-1+/+). Lung inflammation and fibrosis were assessed on days 7, 14, an...
Source: American Journal of Respiratory Cell and Molecular Biology - January 10, 2013 Category: Molecular Biology Authors: Hartopo AB, Emoto N, Vignon-Zellweger N, Suzuki Y, Yagi K, Nakayama K, Hirata KI Tags: Am J Respir Cell Mol Biol Source Type: research

αMβ2 Integrin-Mediated Adhesion and Motility of Interleukin-5-Stimulated Eosinophils on Periostin.
Abstract Periostin is an extracellular matrix protein that is upregulated by T helper cell type 2 (Th2) cytokines in the asthmatic airway and implicated in mouse studies as promoting eosinophil recruitment. We asked whether periostin modulates eosinophil adhesion and motility in vitro. Periostin adsorbed to polystyrene supported adhesion of purified human blood eosinophils stimulated by interleukin-5 (IL-5), IL-3, or granulocyte macrophage-colony stimulating factor (GM-CSF), but did not support adhesion of eosinophils treated with IL-4 or IL-13. The degree of adhesion depended on the concentrations of periostin dur...
Source: American Journal of Respiratory Cell and Molecular Biology - January 10, 2013 Category: Molecular Biology Authors: Johansson MW, Annis DS, Mosher DF Tags: Am J Respir Cell Mol Biol Source Type: research

Role of NOX Proteins in Pseudomonas aeruginosa Induced Lung Inflammation and Permeability.
Conclusions: These data show that P.aeruginosa lung infection up-regulates NOX2 and NOX4 expression, and ROS generation, which play distinct roles in regulating lung inflammation, apoptosis and permeability. PMID: 23306835 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - January 10, 2013 Category: Molecular Biology Authors: Fu P, Mohan V, Mansoor S, Tiruppathi C, Sadikot RT, Natarajan V Tags: Am J Respir Cell Mol Biol Source Type: research

Inflammatory Cytokine Response to Ambient Particles Varies due to Field Collection.
Abstract In-vitro assays of biological activity induced by particulate matter (PM) are a tool for investigating mechanisms of PM health effects. They have potential application to exposure assessment in chronic disease epidemiology. However, there has been little reporting of the impact of real-world PM collection techniques on assay results. Therefore, we examined the effect of sampling duration and post-sampling delays in freezing on PM-induced biological activity. Duplicate samples of respirable ambient Los Angeles PM were collected on polyurethane foam filters during 17 days and during three contemporaneous con...
Source: American Journal of Respiratory Cell and Molecular Biology - January 10, 2013 Category: Molecular Biology Authors: McConnell R, Wu W, Berhane K, Liu F, Verma G, Peden D, Diaz-Sanchez D, Fruin S Tags: Am J Respir Cell Mol Biol Source Type: research

Alcohol causes alveolar epithelial oxidative stress by inhibiting the Nrf2/ARE signaling pathway.
In this study, we determined that alcohol ingestion in vivo or direct alcohol exposure in vitro down-regulated the Nrf2/ARE pathway in lung epithelial cells, decreased the expression of anti-oxidant genes, and lowered intracellular glutathione levels. RNA silencing of Nrf2 gene expression in alveolar epithelial cells in vitro decreased expression of these same anti-oxidant genes and likewise lowered intracellular glutathione levels, findings that mirrored the effects of alcohol. In contrast, treating alcohol-exposed alveolar epithelial cells in vitro with the Nrf2 activator sulforaphane preserved Nrf2 expression, ARE activ...
Source: American Journal of Respiratory Cell and Molecular Biology - January 10, 2013 Category: Molecular Biology Authors: Jensen JS, Fan X, Guidot DM Tags: Am J Respir Cell Mol Biol Source Type: research

Urinary Neurotransmitters Are Selectively Altered in Children with Obstructive Sleep Apnea and Predict Cognitive Morbidity.
CONCLUSIONS: Pediatric OSA is associated with overnight increases in urinary concentrations of catecholamines indicative of heightened sympathetic outflow. Increases in GABA and decreases in taurine could underlie mechanisms of neuronal excitotoxicity and dysfunction. Combinatorial approaches using defined cut-offs in overnight changes of selected neurotransmitters in urine may not only predict OSA, but also the presence of cognitive deficits. Larger cohort studies appear warranted to confirm these findings. PMID: 23306904 [PubMed - as supplied by publisher]
Source: Chest - January 10, 2013 Category: Respiratory Medicine Authors: Kheirandish-Gozal L, McManus CJ, Kellermann GH, Samiei A, Gozal D Tags: Chest Source Type: research

Congenital rubella with agenesis of the inferior cerebellar vermis and total anomalous pulmonary venous drainage: a case report.
We present a case with multiple fetal abnormalities detected on prenatal ultrasound, and confirmed postnatally, including single umbilical artery, severe tricuspid regurgitation, micrognathia and agenesis of the inferior cerebellar vermis. Postnatal echocardiography additionally revealed an unobstructed total anomalous pulmonary venous drainage (TAPVD) into the coronary sinus. Placental examination showed signs of placentitis and PCR on neonatal serum was positive for rubella. Following a multidisciplinary team review, it was decided to provide only supportive care and the infant died at 6 months of age due to a respirator...
Source: The Ultrasound Review of Obstetrics and Gynecology - January 10, 2013 Category: Radiology Authors: Cluver C, Meyer R, Odenaal H, Geerts L Tags: Ultrasound Obstet Gynecol Source Type: research

Cough Aerosols of Mycobacterium tuberculosis Predict New Infection: A Household Contact Study.
CONCLUSIONS: Cough aerosols of M. tuberculosis are produced by a minority of TB patients but predict transmission better than sputum smear microscopy or culture. Cough aerosols may help identify the most infectious TB patients and thus, improve the cost-effectiveness of TB control programs. PMID: 23306539 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Jones-López EC, Namugga O, Mumbowa F, Ssebidandi M, Mbabazi O, Moine S, Mboowa G, Fox MP, Reilly N, Ayakaka I, Kim S, Okwera A, Joloba M, Fennelly KP Tags: Am J Respir Crit Care Med Source Type: research

Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation.
Clinical Risk Factors for Primary Graft Dysfunction after Lung Transplantation. Am J Respir Crit Care Med. 2013 Jan 10; Authors: Diamond JM, Lee JC, Kawut SM, Shah RJ, Localio AR, Bellamy S, Lederer DJ, Cantu E, Kohl BA, Lama VN, Bhorade S, Crespo M, Demissie E, Sonnett J, Wille K, Orens J, Shah AS, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Ware LB, Palmer SM, Christie JD, for the Lung Transplant Outcomes Group Abstract RATIONALE: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting ...
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Diamond JM, Lee JC, Kawut SM, Shah RJ, Localio AR, Bellamy S, Lederer DJ, Cantu E, Kohl BA, Lama VN, Bhorade S, Crespo M, Demissie E, Sonnett J, Wille K, Orens J, Shah AS, Weinacker A, Arcasoy S, Shah PD, Wilkes DS, Ware LB, Palmer SM, Christie JD, for th Tags: Am J Respir Crit Care Med Source Type: research

Th17/Treg Imbalance in Murine Cystic Fibrosis is Linked to IDO Deficiency but Corrected by Kynurenines.
CONCLUSIONS: This study provides a link between tryptophan catabolism and lung immune homeostasis in murine CF, representing a proof-of-concept that targeting pathogenic inflammation via IDO mimetic drugs may benefit CF patients. PMID: 23306541 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Iannitti RG, Carvalho A, Cunha C, De Luca A, Giovannini G, Casagrande A, Zelante T, Vacca C, Fallarino F, Puccetti P, Massi-Benedetti C, Defilippi G, Russo M, Porcaro L, Colombo C, Ratclif L, De Benedictis FM, Romani L Tags: Am J Respir Crit Care Med Source Type: research