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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 26.

Saudi regulations for the accreditation of sleep medicine physicians and technologists
Ahmed S BaHammam, Hamdan Al-Jahdali, Adel S AlHarbi, Ghazi AlOtaibi, Saad M Asiri, Abdulaziz AlSayeghAnnals of Thoracic Medicine 2013 8(1):3-7The professional content of sleep medicine has grown significantly over the past few decades, warranting the recognition of sleep medicine as an independent specialty. Because the practice of sleep medicine has expanded in Saudi Arabia over the past few years, a national regulation system to license and ascertain the competence of sleep medicine physicians and technologists has become essential. Recently, the Saudi Commission for Health Specialties formed the National Committee for t...
Source: Annals of Thoracic Medicine - January 9, 2013 Category: Respiratory Medicine Authors: Ahmed S BaHammamHamdan Al-JahdaliAdel S AlHarbiGhazi AlOtaibiSaad M AsiriAbdulaziz AlSayegh Source Type: research

Accreditation of sleep medicine in the Kingdom of Saudi Arabia: A critical step toward quality outcomes
David GozalAnnals of Thoracic Medicine 2013 8(1):1-2
Source: Annals of Thoracic Medicine - January 9, 2013 Category: Respiratory Medicine Authors: David Gozal Source Type: research

Variability of In Vivo Fluid Dose Distribution in Mouse Airways Is Visualized by High-Speed Synchrotron X-Ray Imaging
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0.
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - January 8, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Olanzapine overdose: Respiratory distress, fever and extrapyramidal symptoms in an infant: case report
Source: Reactions - January 8, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Aspirin: Exacerbated respiratory disease: case report
Source: Reactions - January 8, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Use of extracorporeal membrane oxygenation in combination with high‐frequency oscillatory ventilation in post‐traumatic ARDS
We report on a 26‐year‐old female (Injury Severity Score 29) who had multiple injuries as follows: an unstable pelvic fracture, a blunt abdominal trauma, a blunt trauma of the left thigh, and a thoracic injury. Three days after admission, the patient developed fulminant ARDS (Murray lung injury score of 11 and Horovitz‐ Index <80 mmHg), and vv ECMO therapy was initiated. The Horovitz‐ Index was <80 mm Hg, and the lung compliance was minimal. With HFOV, almost complete recruitment of the lung was achieved, and the fraction of inspired oxygen (FiO2) was significantly reduced. The pelvic fracture was treated...
Source: Acta Anaesthesiologica Scandinavica - January 8, 2013 Category: Anesthesiology Authors: M. GOTHNER, D. BUCHWALD, A. SCHLEBES, J. T. STRAUCH, T. A. SCHILDHAUER, J. SWOL Tags: Case Report Source Type: research

Central nervous system malformations and associated defects diagnosed by obstetric ultrasonography
CONCLUSION: Obstetric ultrasonography presents good sensitivity in the screening for fetal CNS malformations, specially with the constant improvement and control of specialized methods such as Doppler and volumetric ultrasonography (3D/4D), contributing to consolidate its role as a modality of choice in this routine. Magnetic resonance imaging may play a supplementary role, providing information for an even better perinatal care.
Source: Radiologia Brasileira - January 8, 2013 Category: Radiology Source Type: research

Reference values and factors related to thoracic mobility in Brazilian children
CONCLUSIONS: Reference values for thoracic cirtometry were provided for children aged between seven and 11 years old. Sex, age, weight, height, and body mass index did not influence xiphoid respiratory coefficient. The axillary respiratory coefficient was different between ages, from eight years onwards, being significantly influenced by height and weight regardless of sex.OBJETIVO: Suministrar valores de referencia y evaluar los factores que influencian la movilidad torácica de niños de 7 a 11 años. MÉTODOS: Se evaluaron 166 niños de escuelas públicas y privadas (90 muchachas y 76 muchachos) de la ciudad de Natal (R...
Source: Revista Paulista de Pediatria - January 8, 2013 Category: Pediatrics Source Type: research

Profile of prescribers and prescription of antibiotics in upper respiratory infections in Pediatrics
OBJETIVO: Traçar um perfil dos médicos que atendem crianças nos sistemas público (Sistema Único de Saúde) e privado de saúde e verificar como são prescritos antimicrobianos nas infecções das vias aéreas superiores. MÉTODOS: Médicos de algumas cidades do interior do Estado de São Paulo receberam via correio ou nas Unidades Básicas de Saúde uma carta explicativa sobre a pesquisa e o questionário, com perguntas sobre: tempo de graduação, residência médica, carga horária e local de trabalho, forma de atualização, fatores que consideram ao prescrever antimicrobianos e casos clínicos sobre as infecções...
Source: Revista Paulista de Pediatria - January 8, 2013 Category: Pediatrics Source Type: research

Spontaneous cries can alter the physiological well-being and cerebral oxygenation of very preterm infants
Conclusion: Spontaneous cries can alter the homeostasis of VPIs. Their possible adverse consequences and high occurrence emphasize the need for better prevention and response to them.
Source: Early Human Development - January 8, 2013 Category: Perinatology & Neonatology Authors: Claire Zores, André Dufour, Claire Langlet, Benoît Escande, Dominique Astruc, Pierre Kuhn Source Type: research

Infection and acute respiratory distress syndrome during pregnancy: A case series of preventable maternal deaths from southern India
Conclusion: It is necessary to increase the awareness of evidence-based uniform protocols to tackle common medical complaints during pregnancy.
Source: Journal of Infection and Public Health - January 8, 2013 Category: Global & Universal Authors: Akhila Vasudeva, Rajeshwari G. Bhat, Amar Ramachandran, Pratap Kumar Tags: Original Articles Source Type: research

50 years of Pediatric Pulmonology, Progress and Future.
Abstract Development of Pediatric Pulmonology as a speciality in India is steadily improving over past few decades. Present profile of Indian pediatric chest services include: asthma, recurrent infections, bronchiectasis, etc. It is expected to change and the emerging pulmonary illnesses include: human immunodeficiency virus (HIV infection) associated pulmonary illnesses, cystic fibrosis, primary ciliary dyskinesia, bronchopulmonary dysplasia, interstitial lung diseases, gastroesophageal reflux diseases, neuromuscular illnesses, sleep disorders, disorders due to malformations and opportunistic pulmonary infections....
Source: Indian Pediatrics - January 8, 2013 Category: Pediatrics Authors: Kabra SK, Lodha R, Mehta P Tags: Indian Pediatr Source Type: research

Molecular and immunological responses of the giant freshwater prawn, Macrobrachium rosenbergii, to the organophosphorus insecticide, trichlorfon.
Abstract Trichlorfon is an organophosphorus (OP) insecticide that is used as an agriculture pesticide to destroy insects, a human medicine to combat internal parasites, and an ectoparasiticide in the livestock and aquaculture industries, but which has caused aquatic toxicity in the prawn industry. The aim of this study was to investigate the effects of trichlorfon on molecular and enzymatic processes of the immunological response of the giant freshwater prawn, Macrobrachium rosenbergii, at 0, 0.2, and 0.4mgL(-1) with 0, 3, 6, 12, and 24h of exposure. The total hemocyte count (THC), respiratory bursts (RBs), phenolo...
Source: Aquatic Toxicology - January 8, 2013 Category: Toxicology Authors: Chang CC, Rahmawaty A, Chang ZW Tags: Aquat Toxicol Source Type: research

A Study of Artifacts and Their Removal During Forced Oscillation of the Respiratory System.
We present a novel technique to detect these artifacts using multilevel discrete wavelet transforms. FOT was performed with artifacts introduced during separate 60 s recordings at known times in 10 healthy subjects. Brief glottal closures were generated phonetically and confirmed by nasopharyngoscopic imaging of the glottis. Artifacts were detected using Daubechies wavelets by applying a threshold to squared detail coefficients from the wavelet transforms of both pressure and flow signals. Sensitivity and specificity were compared over a range of thresholds for different level squared detail coefficients. Coughs could be ...
Source: Annals of Biomedical Engineering - January 8, 2013 Category: Biomedical Engineering Authors: Bhatawadekar SA, Leary D, Chen Y, Ohishi J, Hernandez P, Brown T, McParland C, Maksym GN Tags: Ann Biomed Eng Source Type: research

Development of a multiplex one step RT-PCR that detects eighteen respiratory viruses in clinical specimens and comparison with real time RT-PCR.
In conclusion, mRT-PCR is a rapid, cost effective, specific and highly sensitive method for detection of respiratory viruses. PMID: 23313883 [PubMed - as supplied by publisher]
Source: Journal of Virological Methods - January 8, 2013 Category: Virology Authors: Choudhary ML, Anand SP, Heydari M, Rane G, Potdar VA, Chadha MS, Mishra AC Tags: J Virol Methods Source Type: research

Hydrophobic Pulmonary Surfactant Proteins SP-B and SP-C Induce Pore Formation in Planar Lipid Membranes: Evidence for Proteolipid Pores.
In this study, we explore the possibility that proteins SP-B and SP-C induce the permeabilization of phospholipid membranes via pore formation. To this end, electrophysiological measurements have been carried out in planar lipid membranes prepared with different lipid/protein mixtures. Our main result is that channel-like structures are detected in the presence of SP-B, SP-C, or the native mixture of both proteins. Current traces show a high variety of conductance states (from pS to nS) that are dependent both on the lipid composition and the applied potential. We also show that the type of host lipid crucially determines ...
Source: Biophysical Journal - January 8, 2013 Category: Physics Authors: Parra E, Alcaraz A, Cruz A, Aguilella VM, Pérez-Gil J Tags: Biophys J Source Type: research

Lipopolysaccharide-induced acute lung injury in rats: Comparative assessment of intratracheal instillation and aerosol inhalation.
This study compares intratracheal bolus instillation (IT) with dose-adjusted aerosol inhalation (IH) of LPS in Wistar rats using both non-invasive and terminal endpoints. The former comprised exhaled nitric oxide (NOE) and 'enhanced pause' (Penh) both measured in spontaneous breathing conscious rats. Terminal endpoints included lung weights, LDH, protein, total cell counts, and cytodifferentiation in bronchoalveolar lavage (BAL). Measurements were made 1, 3, 7, and 14 days after IT instillation (5mg LPS/kg body weight) or 6-hour directed-flow nose-only inhalation exposure to respirable LPS-aerosol at 100mg/m(3) (thoracic d...
Source: Toxicology - January 8, 2013 Category: Toxicology Authors: Liu F, Li W, Pauluhn J, Trübel H, Wang C Tags: Toxicology Source Type: research

Mythmaking in medical education and medical practice.
CONCLUSIONS: These familiar myths have maintained prominent roles in medical thinking because they represent wisdom passed down from eminent sources, they teach physiology and medical skills, and they offer physicians a sense of control in the face of uncertainty. In addition to providing scientific evidence, changing physicians' practice requires acknowledging that even meticulous care cannot always avert bad outcomes. PMID: 23312964 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - January 8, 2013 Category: Internal Medicine Authors: Kaufman E, Lagu T, Hannon NS, Sagi J, Rothberg MB Tags: Eur J Intern Med Source Type: research

The Acute Effects of L-arginine on Hormonal and Metabolic Responses During Submaximal Exercise in Trained Cyclists.
In conclusion, the acute ingestion of L-arginine did not alter any hormonal, metabolic, or cardio-respiratory responses during submaximal exercise except for a small but significant increase in glycerol at the 45 min time point and a reduction in fat oxidation at the start of exercise. PMID: 23319437 [PubMed - as supplied by publisher]
Source: International Journal of Sport Nutrition and Exercise Metabolism - January 8, 2013 Category: Sports Medicine Authors: Forbes SC, Harber V, Bell GJ Tags: Int J Sport Nutr Exerc Metab Source Type: research

Animal model of Mycoplasma fermentans respiratory infection
Conclusions: Mycoplasma fermentans induced a respiratory tract infection and persisted in different organs for several weeks in hamsters. This finding may help to explain the ability of Mycoplasma fermentans to induce pneumonia and chronic infectious diseases in humans.
Source: BMC Research Notes - January 8, 2013 Category: Research Authors: Antonio YáñezAzucena Martínez-RamosTeresa CalixtoFrancisco González-MatusJosé Rivera-TapiaSilvia GionoConstantino GilLilia Cedillo Source Type: research

Mammal‐derived respiratory lipocalin allergensdo not exhibit dendritic cell‐activating capacity
Abstract Most mammal‐derived respiratory allergens belong to the lipocalin family of proteins. Determinants of their allergenic capacity are still unknown.Innate immune cells, in particular dendritic cells,have been shown to be involved in the allergenicity of some proteins.As recognition by dendritic cells is one of the few plausible mechanisms for the allergenicity of proteins, we wanted to investigate their role in the allergenicity of lipocalin allergens.Therefore, we first incubated human monocyte‐derived dendritic cells with immunologically functional recombinant allergens mouse Mus m 1, dog Can f 1 and 2, cow Bo...
Source: Scandinavian Journal of Immunology - January 8, 2013 Category: Allergy & Immunology Authors: Suvi Parviainen, Tuure Kinnunen, Marja Rytkönen‐Nissinen, Anssi Nieminen, Aino Liukko, Tuomas Virtanen Tags: Experimental Immunology Source Type: research

[Polysomnography (PSG) for studying sleep disorders].
Abstract BACKGROUND. Sleeping problems are very common, and many patients need a comprehensive assessment with polysomnography, possibly followed by a sleep latency test. These methods and indications for the tests are described below.METHOD. The article is based on the authors' own literature archives, clinical experience and Retningslinjer for metoder i klinisk neurofysiologi [Guidelines for methodology in clinical neurophysiology]RESULTS. Polysomnography involves monitoring sleep through the course of one night and scoring the stages of sleep on the basis of EEG activity, eye movements and muscular tension. Also...
Source: Tidsskrift for den Norske Laegeforening - January 8, 2013 Category: Journals (General) Authors: Engstrøm M, Rugland E, Skard Heier M Tags: Tidsskr Nor Laegeforen Source Type: research

Potential benefits and pitfalls of respiratory‐gated radiotherapy in the treatment of thoracic malignancy
ConclusionRGRT may reduce doses to organs at risk with the potential for dose escalation. However its implementation requires significant staff training, treatment time and resources. Treatment verification with image guided radiation therapy are essential for safe delivery.
Source: Asia-Pacific Journal of Clinical Oncology - January 8, 2013 Category: Cancer & Oncology Authors: Eric Hau, Melissa Rains, Trang Pham, Rebecca Muirhead, Roland Yeghiaian Alvandi Tags: ORIGINAL ARTICLE Source Type: research

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease
Abstract The worldwide epidemic of obesity and insulin resistance favours nonalcoholic fatty liver disease (NAFLD). Insulin resistance (IR) in the adipose tissue increases lipolysis and the entry of non‐esterified fatty acids (NEFAs) in the liver, whereas IR‐associated hyperinsulinemia promotes hepatic de novo lipogenesis. However, several hormonal and metabolic adaptations are set up in order to restrain hepatic fat accumulation, such as increased mitochondrial fatty acid oxidation (mtFAO). Unfortunately, these adaptations are usually not sufficient to reduce fat accumulation in liver. Furthermore, enhanced mtFAO with...
Source: Hepatology - January 8, 2013 Category: Internal Medicine Authors: Karima Begriche, Julie Massart, Marie‐Anne Robin, Fabrice Bonnet, Bernard Fromenty Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Occupational diseases compensated in the Basque Country (Spain) from 1990 to 2008
ConclusionsThe rise in compensated occupational illnesses in the Basque Country is likely due to a mixture of better recognition of such illnesses and changes in laws, regulations, and administrative procedures. Chronic occupational diseases such as cancer and chronic respiratory diseases, however, remain under‐reported, and care for people with such illnesses represents an undue financial burden on the public health care system and on their families. Am. J. Ind. Med. © 2013 Wiley Periodicals, Inc.
Source: American Journal of Industrial Medicine - January 8, 2013 Category: Occupational Health Authors: Montserrat García Gómez, Félix Urbaneja Arrúe, Steven Markowitz, Rosario Castañeda López, Patricia López Menduiña Tags: Research Article Source Type: research

Renal function and survival in 200 patients undergoing ECMO therapy
Conclusions AKI requiring RRT therapy in patients undergoing ECMO treatment increases mortality in ICU patients. Future studies have to clarify whether it is possible to identify patients who benefit from the combination of ECMO and RRT.
Source: Nephrology Dialysis Transplantation - January 8, 2013 Category: Urology & Nephrology Authors: Kielstein, J. T., Heiden, A. M., Beutel, G., Gottlieb, J., Wiesner, O., Hafer, C., Hadem, J., Reising, A., Haverich, A., Kuhn, C., Fischer, S. Tags: Acute Kidney Injury Source Type: research

Association of Nesfatin-1 and Fat Mass in Cystic Fibrosis
Respiration (DOI:10.1159/000345375)
Source: Respiration - January 7, 2013 Category: Respiratory Medicine Source Type: research

The relevance of monitoring of antibodies against the Polycyclic aromatic hydrocarbon (PAH) and PAH-DNA adducts in serum in relation to lung cancer and chronic obstructive pulmonary disease (COPD).
Abstract Certain substances from the polycyclic aromatic hydrocarbons (PAHs) group are major inducers of respiratory tract carcinogenesis. The presented are the results of a serological epidemiological study aimed at monitoring the levels of anti-PAH antibodies and antibodies to PAH-DNA adducts in serum. The patients studied belonged both to the group of those with known lung disease (COPD and lung cancer), as well as to the healthy population of people who due to the work conditions or those at the place of residence can expect increased exposure to PAHs. In addition to the results proper that confirm increase o...
Source: Neoplasma - January 7, 2013 Category: Cancer & Oncology Authors: Pauk N, Klimesova S, Kara J, Topinka J, Labaj J Tags: Neoplasma Source Type: research

Definition and annotation of (myco)bacterial non-coding RNA
Summary: RNA in bacteria may be broadly classified into coding and non-coding types. The prior, also known as messenger RNA, encode proteins as their final product. The non-coding RNA include all RNAs that are not translated into a protein. Examples of extensively studied and therefore prominent non-coding RNAs include rRNA, tRNA, tmRNA, whose designations reflect the functions performed by these RNAs. Discoveries of non-coding RNAs in mycobacteria have been reported in the recent years. At this early stage of this discipline of mycobacterial research, there is an opportunity for the scientific community to establish a con...
Source: Tuberculosis - January 7, 2013 Category: Respiratory Medicine Authors: Gyanu Lamichhane, Kristine B. Arnvig, Kathleen A. McDonough Tags: Special Issue Articles Source Type: research

Upper and lower airway nitric oxide levels in primary ciliary dyskinesia, cystic fibrosis and asthma
Conclusion: Our findings do not support the hypothesis that NOS and ciliary function are coupled instead suggesting a more generalised mechanism for the low levels of NO seen in PCD. Our findings in CF and asthma corroborate evidence that these are diseases of the lung peripheries and bronchi respectively.
Source: Respiratory Medicine CME - January 7, 2013 Category: Respiratory Medicine Authors: W.T. Walker, A. Liew, A. Harris, J. Cole, J.S. Lucas Tags: Bronchiectasis/Cystic Fibrosis Source Type: research

Intravenous and nebulized magnesium sulfate for treating acute asthma in adults and children: A systematic review and meta-analysis
Conclusion: The use of intravenous magnesium sulfate, in addition to β2-agonists and systemic steroids, in the treatment of acute asthma appears to produce benefits with respect to improve pulmonary function and reduce the number of hospital admissions for children, and only improve pulmonary function for adults. However, the use of nebulized magnesium sulfate just appears to produce benefits for adults.
Source: Respiratory Medicine CME - January 7, 2013 Category: Respiratory Medicine Authors: Zhilei Shan, Ying Rong, Wei Yang, Di Wang, Ping Yao, Jungang Xie, Liegang Liu Tags: Review Articles Source Type: research

The impact of glucocorticoid polymorphisms on markers of neonatal respiratory disease after antenatal betamethasone administration
Conclusion: Several discrete maternal and fetal SNPs in the IPO13 family may be associated with neonatal respiratory outcomes after maternal antenatal corticosteroid treatment for anticipated preterm birth.
Source: American Journal of Obstetrics and Gynecology - January 7, 2013 Category: OBGYN Authors: David M. Haas, Jessica Dantzer, Amalia S. Lehmann, Santosh Philips, Todd C. Skaar, Catherine L. McCormick, Scott J. Hebbring, Jeesun Jung, Lang Li Tags: Obstetrics Source Type: research

Pregnancy during enzyme replacement therapy for late-onset acid maltase deficiency
We report the case of a female patient who developed Pompe’s disease when she was 19. She received enzyme replacement therapy from the age of 35, and after three years of treatment the improvement in her clinical condition was such that she was able to consider having a baby. It was the patient’s wishes to continue with her treatment throughout the entirety of her pregnancy. There were no complications, but there was a clear deterioration in motor and respiratory functions. She delivered at term by Caesarean section, and the child was healthy. Six months later, we noted an improvement of her motor and respiratory funct...
Source: Neuromuscular Disorders - January 7, 2013 Category: Neurology Authors: Fabien Zagnoli, Amelie Leblanc, Christian Blanchard Tags: Research papers Source Type: research

Antigenic specificity of a monovalent versus polyvalent MOMP based Chlamydia pecorum vaccine in koalas (Phascolarctos cinereus).
Abstract Chlamydia continues to be a major pathogen of koalas. The bacterium is associated with ocular, respiratory and urogenital tract infections and a vaccine is considered the best option to limit the decline of mainland koala populations. Over the last 20 years, efforts to develop a chlamydial vaccine in humans have focussed on the use of the chlamydial major outer membrane protein (MOMP). Potential problems with the use of MOMP-based vaccines relate to the wide range of genetic diversity in its four variable domains. In the present study, we evaluated the immune response of koalas vaccinated with a MOMP-based...
Source: Vaccine - January 7, 2013 Category: Allergy & Immunology Authors: Kollipara A, Wan C, Rawlinson G, Brumm J, Nilsson K, Polkinghorne A, Beagley K, Timms P Tags: Vaccine Source Type: research

High-altitude hypoxia and periodic breathing during sleep: gender-related differences.
In conclusion, at high altitude, nocturnal periodic breathing affects males more than females. Females started to present a significant number of central sleep apneas only at the highest reached altitude. After 10 days at 5400 m gender differences in the apnea-hypopnea index similar to those observed after acute exposure were still observed, accompanied by differences in respiratory cycle length. PMID: 23294420 [PubMed - as supplied by publisher]
Source: Journal of Sleep Research - January 7, 2013 Category: Sleep Medicine Authors: Lombardi C, Meriggi P, Agostoni P, Faini A, Bilo G, Revera M, Caldara G, Di Rienzo M, Castiglioni P, Maurizio B, Gregorini F, Mancia G, Parati G, The Highcare Investigators Tags: J Sleep Res Source Type: research

Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
Conclusions: The newly described HRV-C was the most common rhinovirus group detected in HSCT recipients with respiratory infection, with co-pathogens being frequent. Further research is required to understand the activity and pathogenicity of this virus in HSCT recipients.
Source: Journal of Clinical Virology - January 7, 2013 Category: Virology Authors: Patricia E. Ferguson, Nicole M. Gilroy, Cassandra E. Faux, Ian M. Mackay, Theo P. Sloots, Michael D. Nissen, Dominic E. Dwyer, Tania C. Sorrell Tags: Short communications Source Type: research

Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis.
In this study, we investigated the direct and indirect anti-inflammatory effects of tulathromycin in bovine macrophages. The findings indicate that bovine monocyte-derived macrophages and alveolar macrophages readily phagocytose tulathromycin-induced apoptotic neutrophils both in vitro, and in the airways of Mannheimia haemolytica-infected calves. Moreover, tulathromycin promotes delayed, concentration-dependent apoptosis, but not necrosis, in bovine macrophages in vitro. Activation of Caspase-3 and detection of mono- and oligonucleosomes in bovine monocyte-derived macrophages treated with tulathromycin was observed 12 h p...
Source: Antimicrobial Agents and Chemotherapy - January 7, 2013 Category: Microbiology Authors: Fischer CD, Beatty JK, Duquette SC, Morck DW, Lucas MJ, Buret AG Tags: Antimicrob Agents Chemother Source Type: research

Identification of disease specific pathways using in vivo SILAC proteomics in dystrophin deficient mdx mouse.
Abstract Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by a mutation in the dystrophin gene. DMD is characterized by progressive weakness of skeletal, cardiac and respiratory muscles. The molecular mechanisms underlying dystrophy-associated muscle weakness and damage are not well understood. Quantitative proteomic techniques would help to identify disease specific pathways. Recent advances in in vivo metabolic labeling of mammals by stable isotope-labeled amino acids [13C6-lysine (SILAC mouse) or 15N (SILAM)] have enabled accurate quantitative analysis of the proteomes of the whole ...
Source: Molecular and Cellular Proteomics : MCP - January 7, 2013 Category: Molecular Biology Authors: Rayavarapu S, Coley W, Cakir E, Jahnke V, Takeda S, Aoki Y, Gordish-Dressman H, Jaiswal JK, Hoffman EP, Brown KJ, Hathout Y, Nagaraju K Tags: Mol Cell Proteomics Source Type: research

Displacement of predominant respiratory syncytial virus genotypes in Malaysia between 1989-2011.
Abstract From 1989-2011 in Kuala Lumpur, Malaysia, multiple genotypes from both respiratory syncytial virus (RSV) subgroups were found co-circulating each year. RSV-A subgroup predominated in 12 out of 17 years with the remaining years predominated by RSV-B subgroup. Local RSV strains exhibited temporal clustering with RSV strains reported in previous epidemiological studies. Every few years, the existing predominant genotype was replaced by a new genotype. The RSV-A genotypes GA2, GA5 and GA7 were replaced by NA1 and NA2, while BA became the predominant RSV-B genotype. A unique local cluster, BA12, was seen in 200...
Source: Infection, Genetics and Evolution - January 7, 2013 Category: Genetics & Stem Cells Authors: Khor CS, Sam IC, Hooi PS, Chan YF Tags: Infect Genet Evol Source Type: research

Do Seasonal Changes and Climate Influence the Etiology of Community Acquired Pneumonia?
CONCLUSIONS: In our area, Streptococcus pneumoniae was the most common etiological agent in winter with low temperatures; in summer, with high temperatures, the most frequent was Legionella pneumophila. PMID: 23305778 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - January 7, 2013 Category: Respiratory Medicine Authors: Herrera-Lara S, Fernández-Fabrellas E, Cervera-Juan A, Blanquer-Olivas R Tags: Arch Bronconeumol Source Type: research

Chronic obstructive pulmonary disease and functioning: implications for rehabilitation based on the ICF framework.
Conclusions: Recommendations were drawn from this study in order to improve comprehensive rehabilitation interventions for patients with COPD based on ICF framework. Implications for Rehabilitation Functioning of patients with Chronic Obstructive Pulmonary Disease can be comprehensively assessed in a worldwide common language - the International Classification of Functioning, Disability and Health. Rehabilitation interventions for patients with Chronic Obstructive Pulmonary Disease should be designed according to the International Classification of Functioning, Disability and Health framework, i.e. assessing and moni...
Source: Disability and Rehabilitation - January 7, 2013 Category: Rehabilitation Authors: Jácome C, Marques A, Gabriel R, Figueiredo D Tags: Disabil Rehabil Source Type: research

Potential mechanisms of sudden unexpected death in epilepsy.
This article is part of a Special Issue entitled Translational Epilepsy Research. PMID: 23305781 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - January 7, 2013 Category: Neurology Authors: Tolstykh GP, Cavazos JE Tags: Epilepsy Behav Source Type: research

Prevalence of human metapneumovirus in children with acute lower respiratory infection in Changsha, China
Abstract Human metapneumovirus (hMPV) causes acute respiratory infections in children. The prevalence and clinical characteristics of hMPV were determined in nasopharyngeal aspirates of children in Changsha, China. Reverse transcription‐polymerase chain reaction (RT‐PCR) or PCR was employed to screen for both hMPV and other common respiratory viruses in 1,165 nasopharyngeal aspirate specimens collected from children with lower respiratory tract infections from September 2007 to August 2008. All PCR products were sequenced, and demographic and clinical data were collected from all patients. Seventy‐six of 1,165 (6.5%)...
Source: Journal of Medical Virology - January 7, 2013 Category: Virology Authors: Ni‐guang Xiao, Bing Zhang, Zhi‐ping Xie, Qiong‐hua Zhou, Rong‐fang Zhang, Li‐li Zhong, Xiao‐fang Ding, Jia Li, Jing‐rong Song, Han‐chun Gao, Yun‐de Hou, Zhao‐jun Duan Tags: Research Article Source Type: research

Prenatal diagnosis and outcome of absent pulmonary valve syndrome: contemporary single‐center experience and review of the literature
ConclusionOutcome after fetal diagnosis of APVS was significantly better in this study compared with those of previous fetal series, with a low mortality rate for actively managed patients. Copyright © 2012 ISUOG. Published by John Wiley & Sons, Ltd.
Source: Ultrasound in Obstetrics and Gynecology - January 7, 2013 Category: Radiology Authors: D. Wertaschnigg, M. Jaeggi, D. Chitayat, P. Shannon, G. Ryan, M. Thompson, S. J. Yoo, E. Jaeggi Tags: Original Paper Source Type: research

Influence of larger graft weight to recipient weight on the post‐liver transplantation course
Abstract Size matching between recipient and donor livers is an important factor in organ allocation in the context of liver transplantation (LT). The aim of this study was to determine whether a large graft for recipient size influenced the post‐transplant course. One hundred and sixty‐two successive LT recipients were included and retrospectively divided into two groups: 25 (15%) had a graft‐to‐recipient weight ratio (GWRW) ≥2.5% and 137 (85%) had a GWRW <2.5%. Postoperative complications and outcomes were recorded. In the GWRW >2.5% group, more end‐to‐end caval replacement (72% vs. 38%, p = 0.003) ...
Source: Clinical Transplantation - January 7, 2013 Category: Transplant Surgery Authors: Eric Levesque, Julie Duclos, Oriana Ciacio, Rene Adam, Denis Castaing, Eric Vibert Tags: Original Article Source Type: research

Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I
Succinate‐driven oxidation via complex II (CII) may have a significant contribution towards the high rates of production of reactive oxygen species (ROS) by mitochondria. Here, we show that the CII Q site inhibitor thenoyltrifluoroacetone (TTFA) blocks succinate + rotenone‐driven ROS production, whereas the complex III (CIII) Qo inhibitor stigmatellin has no effect, indicating that CII, not CIII, is the ROS‐producing site. The complex I (CI) inhibitor rotenone partially reduces the ROS production driven by high succinate levels (5 mm), which is commonly interpreted as being due to inhibition of a reverse elect...
Source: FEBS Journal - January 7, 2013 Category: Research Authors: Rafael Moreno‐Sánchez, Luz Hernández‐Esquivel, Nadia A. Rivero‐Segura, Alvaro Marín‐Hernández, Jiri Neuzil, Stephen J. Ralph, Sara Rodríguez‐Enríquez Tags: Original Article Source Type: research

Influenza surveillance in the Pacific island countries and territories during the 2009 pandemic: an observational study
Conclusions: Pandemic influenza spread rapidly throughout the Pacific despite enormous distances and relative isolation. Tokelau and Pitcairn may be the only jurisdictions to have remained pandemic-free. Despite being well-prepared, Pacific island countries and territories experienced significant morbidity and mortality, consistent with other indigenous and low-resource settings.For the first time, regional influenza-like-illness surveillance was conducted in the Pacific, allowing health authorities to monitor the pandemic's spread and severity in real-time.Future regional outbreak responses will likely benefit from the le...
Source: BMC Infectious Diseases - January 7, 2013 Category: Infectious Diseases Authors: Jacobus KoolBoris PavlinJennie MustoAkanisi Dawainavesi Source Type: research

Feasibility of transapical aortic valve replacement through a left ventricular apical diverticulum
Transapical aortic valve replacement is an established technique performed in high-risk patients with symptomatic aortic valve stenosis and vascular disease contraindicating trans-vascular and trans-aortic procedures. The presence of a left ventricular apical diverticulum is a rare event and the treatment depends on dimensions and estimated risk of embolisation, rupture, or onset of ventricular arrhythmias. The diagnosis is based on standard cardiac imaging and symptoms are very rare. In this case report we illustrate our experience with a 81 years old female patient suffering from symptomatic aortic valve stenosis, respir...
Source: Journal of Cardiothoracic Surgery - January 7, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Enrico FerrariMathieu Van SteenbergheJegaruban NamasivayamDenis BerdajsLars NiclaussLudwig von Segesser Source Type: research

Temporal changes in respiratory adenovirus serotypes circulating in the greater Toronto area, Ontario, during December 2008 to April 2010
Conclusions: There was a gradual shift in prevailing adenovirus serotypes during the 17 month study period, from predominantly HAdV-3 to HAdV-2. If an adenovirus vaccine were to be broadly implemented, multiple serotypes should be included.
Source: Virology Journal - January 7, 2013 Category: Virology Authors: Kaniza AbbasErnesto LombosVenkata DuvvuriRomy OlshaRachel HigginsJonathan Gubbay Source Type: research