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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

The central role of mitochondria in axonal degeneration in multiple sclerosis
Neurodegeneration in multiple sclerosis (MS) is related to inflammation and demyelination. In acute MS lesions and experimental autoimmune encephalomyelitis focal immune attacks damage axons by injuring axonal mitochondria. In progressive MS, however, axonal damage occurs in chronically demyelinated regions, myelinated regions and also at the active edge of slowly expanding chronic lesions. How axonal energy failure occurs in progressive MS is incompletely understood. Recent studies show that oligodendrocytes supply lactate to myelinated axons as a metabolic substrate for mitochondria to generate ATP, a process which will ...
Source: Multiple Sclerosis - December 17, 2014 Category: Neurology Authors: Campbell, G. R., Worrall, J. T., Mahad, D. J. Tags: Topical Review Source Type: research

Comparison of CT-derived ventilation maps with deposition patterns of inhaled microspheres in rats
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Pulmonary preconditioning, injury, and inflammation modulate expression of the candidate tumor suppressor gene ECRG4 in lung
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Hypoxia-induced acute lung injury is aggravated in Streptozotocin diabetic mice
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

DNA methylation profile and expression of surfactant protein A2 gene in lung cancer
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Comprehensive analysis of genes, pathways, and TFs in nonsmoking Taiwan females with lung cancer
Experimental Lung Research, Ahead of Print. (Source: Experimental Lung Research)
Source: Experimental Lung Research - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Validation of a commercial serodiagnostic kit for diagnosing pulmonary Mycobacterium avium complex disease
(Source: International Journal of Tuberculosis and Lung Disease)
Source: International Journal of Tuberculosis and Lung Disease - December 16, 2014 Category: Respiratory Medicine Authors: Kitada, S.Yoshimura, K.Miki, K.Miki, M.Hashimoto, H.Matsui, H.Kuroyama, M.Ageshio, F.Kagawa, H.Mori, M.Maekura, R.Kobayashi, K. Tags: ORIGINAL ARTICLES Source Type: research

Tiotropium as part of inhaled polytherapy: Adherence and associated health‐care utilization
ConclusionsAdherence to Tiotropium was associated with decreased hospitalizations only among patients who improved their adherence to LABA and/or ICS as well. Exploring reasons for high non‐adherence and ways to improve adherence may optimize utilization of the scarce hospital resources. (Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Authors: Tzahit Simon‐Tuval, Nimrod Maimon Tags: Original Article Source Type: research

The Dutch Functional Performance Inventory: Validity and Reliability in Patients With Chronic Obstructive Lung Disease
DiscussionScores on the Dutch FPI were reliable and reproducible. Evidence for validity was reasonable, but less strong than that reported in studies from other populations. (Source: Nursing Research)
Source: Nursing Research - December 16, 2014 Category: Nursing Tags: Feature Articles Source Type: research

Endobronchial ultrasound-guided transbronchial needle aspiration in lung cancer diagnosis and staging
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - December 16, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Proceedings of the Bovine Respiratory Disease Symposium 2014: New Approaches to Bovine Respiratory Disease Prevention, Management, and Diagnosis
Editorial Amy E. Young, Amelia R. Woolums, Animal Health Research Reviews, Volume 15 Issue 02, pp 119-119Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

The impact of bovine respiratory disease: the current feedlot experience
Review Articles Michael Engler, Paul Defoor, Carter King, Justin Gleghorn, Animal Health Research Reviews, Volume 15 Issue 02, pp 126-129Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

Timely diagnosis of dairy calf respiratory disease using a standardized scoring system
Review Articles Sheila M. McGuirk, Simon F. Peek, Animal Health Research Reviews, Volume 15 Issue 02, pp 145-147Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

Agreement between bovine respiratory disease scoring systems for pre-weaned dairy calves
Review Articles Sharif S. Aly, William J. Love, Deniece R. Williams, Terry W. Lehenbauer, Alison Van Eenennaam, Christiana Drake, Philip H. Kass, Thomas B. Farver, Animal Health Research Reviews, Volume 15 Issue 02, pp 148-150Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

Genetics of bovine respiratory disease in cattle: can breeding programs reduce the problem?
Review Articles Donagh P. Berry, Animal Health Research Reviews, Volume 15 Issue 02, pp 151-156Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

How stress alters immune responses during respiratory infection
Review Articles Philip Griebel, Kevin Hill, Joseph Stookey, Animal Health Research Reviews, Volume 15 Issue 02, pp 161-165Abstract (Source: Animal Health Research Reviews)
Source: Animal Health Research Reviews - December 16, 2014 Category: Veterinary Research Source Type: research

Evaluation of clinical bradycardiac effect and respiratory adverse effect of β-blocking agents in coronary computed tomography angiography based on theoretical analysis
In this study, we analyzed the clinical bradycardiac effects and the adverse respiratory effects of five β-blocking agents (landiolol, esmolol, propranolol, metoprolol and atenolol) used for CCTA. The changes of the occupancy binding to β1 or β2 receptor of these drugs were calculated based on the receptor occupancy theory. Thereafter, we predicted both the rate of heart rate decline (▲HR) as a clinical effect and the rate of decrease in forced expiratory volume in 1 s (▲FEV1) as an adverse effect, by using the ternary complex model. The results showed that the drugs with ▲HR greater than 10 %, necessary for CCT...
Source: European Journal of Drug Metabolism and Pharmacokinetics - December 16, 2014 Category: Drugs & Pharmacology Source Type: research

Hospitalizations associated with influenza and respiratory syncytial virus among patients attending a network of private hospitals in South Africa, 2007¿2012
Background: Influenza and respiratory syncytial virus (RSV) infection are common causes of lower respiratory tract illness. Data on their burden in low and middle-income settings and from Africa are scarce. We aimed to estimate age-specific rates of hospitalization attributable to influenza and RSV among patients attending private hospitals in South Africa during 2007?2012. Methods: We estimated annual age-specific rates of influenza- and RSV-associated hospitalization (that is respiratory hospitalizations likely due to influenza or RSV infection) by applying regression models to monthly administrative hospitalization data...
Source: BMC Infectious Diseases - December 16, 2014 Category: Infectious Diseases Authors: Robert KyeyagalireStefano TempiaAdam CohenAdrian SmithJohanna McAnerneyVeerle Dermaux-MsimangCheryl Cohen Source Type: research

Knowledge and attitude of healthcare workers about middle east respiratory syndrome in multispecialty hospitals of qassim, Saudi Arabia
Background: With the increase in prevalence of Middle East Respiratory Syndrome (MERS), healthcare workers (HCWs) are at risk of acquiring and subsequently transmitting this lethal virus. In view of this, HCWs were evaluated for their knowledge of and attitude towards MERS in Saudi Arabia. Methods: A cross sectional study was performed in two hospitals of Qassim region in Saudi Arabia. A total of 280 healthcare workers were selected to participate in this study. Knowledge and attitude were assessed by using self-administered and pretested questionnaire. Descriptive statistics were carried out to express participants' demog...
Source: BMC Public Health - December 16, 2014 Category: Consumer Health News Authors: Muhammad KhanShahjahan ShahAkram AhmadOmotayo Fatokun Source Type: research

Issue Information
(Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Tags: Issue Information Source Type: research

The Editor recommends this issue's articles to the reader
See articles, page 66 and page 101 (Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Tags: Editor's Choice Source Type: research

Celebrating 20 years of Respirology
(Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Authors: Peter Eastwood, Lieve Bultynck Tags: Editorial Source Type: research

Management of malignant pleural effusion
(Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Authors: Graham Simpson, Daniel J. Judge Tags: Correspondences Source Type: research

Acknowledgements
(Source: Respirology)
Source: Respirology - December 16, 2014 Category: Respiratory Medicine Tags: Acknowledgements Source Type: research

Development of a risk-adjusted in-hospital mortality prediction model for community-acquired pneumonia: a retrospective analysis using a Japanese administrative database
Conclusions: Our mortality prediction models using administrative data showed good discriminatory power in CAP patients. These risk-adjustment models may support improvements in quality of care through accurate hospital evaluations and inter-hospital comparisons. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 16, 2014 Category: Respiratory Medicine Authors: Hironori UematsuSusumu KunisawaNoriko SasakiHiroshi IkaiYuichi Imanaka Source Type: research

Expiratory flow rate, breath hold and anatomic dead space influence electronic nose ability to detect lung cancer
Conclusions: We have shown that expiratory flow, breath hold and dead space influence exhaled volatile compound pattern assessed with electronic nose. These findings suggest critical methodological recommendations to standardise sample collections for electronic nose measurements. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 16, 2014 Category: Respiratory Medicine Authors: Andras BikovMarton HernadiBeata KorosiLaszlo KunosGabriella ZsambokiZoltan SuttoAdam TarnokiDavid TarnokiGyorgy LosonczyIldiko Horvath Source Type: research

Individualised oxygen delivery targeted haemodynamic therapy in high-risk surgical patients: a multicentre, randomised, double-blind, controlled, mechanistic trial
Publication date: Available online 16 December 2014 Source:The Lancet Respiratory Medicine Author(s): Gareth L Ackland , Sadaf Iqbal , Laura Gallego Paredes , Andrew Toner , Craig Lyness , Nicholas Jenkins , Phoebe Bodger , Shamir Karmali , John Whittle , Anna Reyes , Mervyn Singer , Mark Hamilton , Maurizio Cecconi , Rupert M Pearse , Susan V Mallett , Rumana Z Omar Background Morbidity after major surgery is associated with low oxygen delivery. Haemodynamic therapy aimed at increasing oxygen delivery in an effort to reduce oxygen debt, tissue injury, and morbidity, is controversial. The most appropriate target for this...
Source: The Lancet Respiratory Medicine - December 16, 2014 Category: Respiratory Medicine Source Type: research

Patients waking up to the benefits of interrupted sedation
Publication date: Available online 16 December 2014 Source:The Lancet Respiratory Medicine Author(s): Talha Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 16, 2014 Category: Respiratory Medicine Source Type: research

The parasympathetic system: a renewed role in goal-directed therapy
Publication date: Available online 16 December 2014 Source:The Lancet Respiratory Medicine Author(s): Soren Sondergaard (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 16, 2014 Category: Respiratory Medicine Source Type: research

IJERPH, Vol. 11, Pages 13117-13129: Chlorpyrifos Exposure and Respiratory Health among Adolescent Agricultural Workers
The objective of this study was to assess CPF exposure and lung function among Egyptian adolescents. We conducted a 10-month study of male adolescent pesticide applicators (n = 38) and non-applicators of similar age (n = 24). Urinary 3,5,6-trichloro-2-pyridinol (TPCy), a CPF-specific metabolite, was analyzed in specimens collected throughout the study. Spirometry was performed twice after pesticide application: day 146, when TCPy levels were elevated and day 269, when TCPy levels were near baseline. Applicators had higher levels of TCPy (mean cumulative TCPy day 146 = 33,217.6; standard deviation (SD) = 49,179.3) than non-...
Source: International Journal of Environmental Research and Public Health - December 16, 2014 Category: Environmental Health Authors: Catherine CallahanManal Al-BatanonyAhmed IsmailGaafar Abdel-RasoulOlfat HendyJames OlsonDiane RohlmanMatthew Bonner Tags: Article Source Type: research

Carbon mineralization is promoted by phosphorus and reduced by nitrogen addition in the organic horizon of northern hardwood forests
Publication date: February 2015 Source:Soil Biology and Biochemistry, Volume 81 Author(s): Melany Fisk , Sharon Santangelo , Kevan Minick Limitations to the respiratory activity of heterotrophic soil microorganisms exert important controls of CO2 efflux from soils. In the northeastern US, ecosystem nutrient status varies across the landscape and changes with forest succession following disturbance, likely impacting soil microbial processes regulating the transformation and emission of carbon (C). We tested whether nitrogen (N) or phosphorus (P) limit the mineralization of soil organic C (SOC) or that of added C sources i...
Source: Soil Biology and Biochemistry - December 16, 2014 Category: Biology Source Type: research

Mitochondrial function contributes to oxysterols-induced osteogenic differentiation in mouse embryonic stem cells
This study investigated the effect of an oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on osteogenic differentiation of ESCs and the alterations to mitochondrial activity during differentiation. Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity, matrix mineralization, mRNA expression of osteogenic factors, runt-related transcription factor 2, osterix, and osteocalcin, and protein levels of collagen type IA (COLIA) and osteopontin (OPN). Treatment of cells with SS increased osteoinductive activity compared to the control group. Intracellular reactive oxygen ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - December 16, 2014 Category: Molecular Biology Source Type: research

Analysis and comparative genomics of ICEMh1, a novel integrative and conjugative element (ICE) of Mannheimia haemolytica
Conclusions These findings showed that ICEs, with structurally variable resistance gene regions, are present in BRD-associated Pasteurellaceae, can easily spread across genus borders and enable the acquisition of multidrug resistance via a single horizontal gene transfer event. This poses a threat to efficient antimicrobial chemotherapy of BRD-associated bacterial pathogens. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 16, 2014 Category: Microbiology Authors: Eidam, C., Poehlein, A., Leimbach, A., Michael, G. B., Kadlec, K., Liesegang, H., Daniel, R., Sweeney, M. T., Murray, R. W., Watts, J. L., Schwarz, S. Tags: Original research Source Type: research

Dominance of international 'high-risk clones' among metallo-{beta}-lactamase-producing Pseudomonas aeruginosa in the UK
Conclusions The incidence of MBL-producing P. aeruginosa is increasing in the UK. The majority of these isolates belong to several ‘high-risk clones’, which have been previously reported internationally as host clones of MBLs. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - December 16, 2014 Category: Microbiology Authors: Wright, L. L., Turton, J. F., Livermore, D. M., Hopkins, K. L., Woodford, N. Tags: Original research Source Type: research

Host Hydrogen Rather than That Produced by the Pathogen Is Important for Salmonella enterica Serovar Typhimurium Virulence [Bacterial Infections]
Salmonella enterica serovar Typhimurium utilizes molecular hydrogen as a substrate in various respiratory pathways, via H2-uptake enzymes termed Hya, Hyb, and Hyd. A different hydrogenase, the hydrogen-evolving Hyc enzyme, removes excess reductant during fermentative growth. Virulence phenotypes conferred by mutations in hyc genes, either alone or in combination with mutations in the H2-uptake enzyme genes, are addressed. Anaerobically grown hycB or hycC single-deletion strains were more sensitive to acid than the wild-type strain, but the hyc strains were like the virulent parent strain with respect to both mouse morbidit...
Source: Infection and Immunity - December 16, 2014 Category: Infectious Diseases Authors: Lamichhane-Khadka, R., Benoit, S. L., Miller-Parks, E. F., Maier, R. J. Tags: Bacterial Infections Source Type: research

Sterilizing Immunity Elicited by Neisseria meningitidis Carriage Shows Broader Protection than Predicted by Serum Antibody Cross-Reactivity in CEACAM1-Humanized Mice [Host Response and Inflammation]
In this study, we establish that transgenic mice expressing human CEACAM1 support nasal colonization by a variety of strains of different capsular types. Next, we nasally challenged these mice with either of the N. meningitidis strains H44/76 (serogroup B, ST-32) and 90/18311 (serogroup C, ST-11), while following the induction of strain-specific immunoglobulin. When these antisera were tested for reactivity with a diverse panel of N. meningitidis strains, very low levels of antibody were detected against all meningococcal strains, yet a mutually exclusive "fingerprint" of high-level cross-reactivity toward certain strains ...
Source: Infection and Immunity - December 16, 2014 Category: Infectious Diseases Authors: Johswich, K. O., McCaw, S. E., Strobel, L., Frosch, M., Gray-Owen, S. D. Tags: Host Response and Inflammation Source Type: research

Contribution of Veillonella parvula to Pseudomonas aeruginosa-Mediated Pathogenicity in a Murine Tumor Model System [Bacterial Infections]
In this study, we investigated the specific interactions of the most dominant bacterial CF pathogen, Pseudomonas aeruginosa, with the anaerobic bacterium Veillonella parvula, which has been recovered at comparable cell numbers from the respiratory tract of CF patients. In addition to growth competition experiments, transcriptional profiling, and analyses of biofilm formation by in vitro studies, we used our recently established in vivo murine tumor model to investigate mutual influences of the two pathogens during a biofilm-associated infection process. We found that P. aeruginosa and V. parvula colonized distinct niches w...
Source: Infection and Immunity - December 16, 2014 Category: Infectious Diseases Authors: Pustelny, C., Komor, U., Pawar, V., Lorenz, A., Bielecka, A., Moter, A., Gocht, B., Eckweiler, D., Musken, M., Grothe, C., Lunsdorf, H., Weiss, S., Haussler, S. Tags: Bacterial Infections Source Type: research

Molecular pathology analyses of two fatal human infections of avian influenza A(H7N9) virus
Conclusions  Our findings suggest that H7N9 influenza virus induced an immunological response towards overt pulmonary inflammation and systemic lymphopenia which led to intense alveolar damage and respiratory failure. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 16, 2014 Category: Pathology Authors: Feng, Y., Hu, L., Lu, S., Chen, Q., Zheng, Y., Zeng, D., Zhang, J., Zhang, A., Chen, L., Hu, Y., Zhang, Z. Tags: Immunology (including allergy), Pneumonia (infectious disease), TB and other respiratory infections, Inflammation, Molecular biology, Pneumonia (respiratory medicine) Original article Source Type: research

Ion Torrent next-generation sequencing for routine identification of clinically relevant mutations in colorectal cancer patients
Conclusions Ion Torrent AmpliSeq Colon and Lung Cancer Panel sequencing is as robust as Sanger sequencing in routine diagnostics to select patients for anti-epidermal growth factor receptor (EGFR) therapy for metastatic colorectal cancer. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - December 16, 2014 Category: Pathology Authors: Malapelle, U., Vigliar, E., Sgariglia, R., Bellevicine, C., Colarossi, L., Vitale, D., Pallante, P., Troncone, G. Tags: Molecular genetics, Colon cancer, Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research

Ets homologous factor regulates pathways controlling response to injury in airway epithelial cells
Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithelial cell types including those lining the respiratory system. Disruption of the airway epithelium is central to many lung diseases, and a network of transcription factors coordinates its normal function. EHF can act as a transcriptional activator or a repressor, though its targets in lung epithelial cells are largely uncharacterized. Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq), showed that the majority of EHF binding sites in lung epithelial cells are intergenic or intronic and coincide with putative enhancer...
Source: Nucleic Acids Research - December 16, 2014 Category: Research Authors: Fossum, S. L., Mutolo, M. J., Yang, R., Dang, H., O'Neal, W. K., Knowles, M. R., Leir, S.-H., Harris, A. Tags: Gene regulation, Chromatin and Epigenetics Source Type: research

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation
Members of the pentatricopeptide repeat domain (PPR) protein family bind RNA and are important for post-transcriptional control of organelle gene expression in unicellular eukaryotes, metazoans and plants. They also have a role in human pathology, as mutations in the leucine-rich PPR-containing (LRPPRC) gene cause severe neurodegeneration. We have previously shown that the mammalian LRPPRC protein and its Drosophila melanogaster homolog DmLRPPRC1 (also known as bicoid stability factor) are necessary for mitochondrial translation by controlling stability and polyadenylation of mRNAs. We here report characterization of DmLRP...
Source: Nucleic Acids Research - December 16, 2014 Category: Research Authors: Baggio, F., Bratic, A., Mourier, A., Kauppila, T. E. S., Tain, L. S., Kukat, C., Habermann, B., Partridge, L., Larsson, N.-G. Tags: RNA Source Type: research

Symptoms of depression impact the course of lung function in adolescents and adults with cystic fibrosis
Conclusion: The findings emphasise the need to screen patients with CF for symptoms of depression and to treat co-morbid depression. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 16, 2014 Category: Respiratory Medicine Authors: Astrid FidikaMarion HerleLutz Goldbeck Source Type: research