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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Effects of Air Pollution-Related Heavy Metals on the Viability and Inflammatory Responses of Human Airway Epithelial Cells
Various metals produced from human activity are ubiquitously detected in ambient air. The metals may lead to induction and/or exacerbation of respiratory diseases, but the significant metals and factors contributing to such diseases have not been identified. To compare the effects of each metal and different oxidation states of metals on human airway, we examined the viability and production of interleukin (IL)-6 and IL-8 using BEAS-2B cell line, derived from human airway epithelial cells. Airway epithelial cells were exposed to Mn2+, V4+, V5+, Cr3+, Cr6+, Zn2+, Ni2+, and Pb2+ at a concentration of 0.5, 5, 50, or 500 μm...
Source: International Journal of Toxicology - April 22, 2015 Category: Toxicology Authors: Honda, A., Tsuji, K., Matsuda, Y., Hayashi, T., Fukushima, W., Sawahara, T., Kudo, H., Murayama, R., Takano, H. Tags: Regular Articles Source Type: research

Comment on ‘Comparative analysis of the isovolume calibration method for non-invasive respiratory monitoring techniques based on area transduction versus circumference transduction using the connected cylinders model’ (2011 Physiol. Meas. 32 1265–74)
An analysis introduced by the authors in 2011 examining the robustness of the isovolume method for the calibration of the respiratory inductive plethysmograph based on the connected cylinders particular model of Konno and Mead’s generalized two-compartment model of respiration is extended. It is demonstrated that extending this to a more physically realistic geometrical model, termed the connected prismatic elliptical segments model, does not enhance the earlier analysis, and that the analysis can easily be proven to cover all area-based transduction sensors, irrespective of the actual geometry of the compartments....
Source: Physiological Measurement - April 22, 2015 Category: Physiology Authors: A T Augousti and A Radosz Source Type: research

Anti-tumour effect of metformin in canine mammary gland tumour cells
In conclusion, metformin exhibited an anti-tumour effect in metastatic CMGT cells through AMPK-independent cell cycle arrest. Its mechanism of action differed in the non-metastatic clone, where AMPK activation and mTOR inhibition were observed. (Source: The Veterinary Journal)
Source: The Veterinary Journal - April 22, 2015 Category: Veterinary Research Source Type: research

Optoelectronic plethysmography to evaluate the effect of posture on breathing kinematics in spinal cord injury: a cross sectional study.
CONCLUSIONS: Optoelectronic plethysmography measurements showed that even if in supine position there is an improvement in respiratory functional parameters, the respiratory kinematics of the chest wall is disadvantaged. CLINICAL REHABILITATION IMPACT: Our study suggest that the use of abdominal binders could reproduce in sitting position the positive effect of supine position on diaphragm, that could work at a more favorable point of its length tension curve. PMID: 25900344 [PubMed - as supplied by publisher] (Source: Physica Medica)
Source: Physica Medica - April 22, 2015 Category: Physics Authors: Miccinilli S, Morrone M, Bastianini F, Molinari M, Scivoletto G, Silvestri S, Ranieri F, Sterzi S Tags: Eur J Phys Rehabil Med Source Type: research

Sendai virus recombinant vaccine expressing a secreted, unconstrained respiratory syncytial virus fusion protein protects against RSV in cotton rats
The respiratory syncytial virus (RSV) is responsible for as many as 199000 annual deaths worldwide. Currently, there is no standard treatment for RSV disease and no vaccine. Sendai virus (SeV) is an attractive pediatric vaccine candidate because it elicits robust and long-lasting virus-specific B cell and T cell activities in systemic and mucosal tissues. The virus serves as a gene delivery system as well as a Jennerian vaccine against its close cousin, human parainfluenza virus type 1. Here we describe the testing of a recombinant SeV (SeVRSV-Fs) that expresses an unconstrained, secreted RSV-F protein as a vaccine against...
Source: International Immunology - April 22, 2015 Category: Allergy & Immunology Authors: Zhan, X., Slobod, K. S., Jones, B. G., Sealy, R. E., Takimoto, T., Boyd, K., Surman, S., Russell, C. J., Portner, A., Hurwitz, J. L. Tags: Original Research Source Type: research

Pulmonary Complications of Cardiopulmonary Bypass
Pulmonary complications after use of extracorporeal circulation are common and range from transient hypoxemia with altered gas exchange to Acute Respiratory Distress Syndrome (ARDS), with variable severity. Similar to other end organ dysfunction after cardiac surgery with extracorporeal circulation, pulmonary complications are attributed to the inflammatory response, ischemia-reperfusion injury and reactive oxygen species liberated as a result of cardiopulmonary bypass. Several factors common in cardiac surgery with extracorporeal circulation may worsen the risk for pulmonary complications including atelectasis, transfusio...
Source: Best Practice and Research. Clinical Anaesthesiology - April 22, 2015 Category: Anesthesiology Authors: Julie L. Huffmyer, Danja S. Groves Source Type: research

A cluster randomised trial of cloth masks compared with medical masks in healthcare workers
Conclusions This study is the first RCT of cloth masks, and the results caution against the use of cloth masks. This is an important finding to inform occupational health and safety. Moisture retention, reuse of cloth masks and poor filtration may result in increased risk of infection. Further research is needed to inform the widespread use of cloth masks globally. However, as a precautionary measure, cloth masks should not be recommended for HCWs, particularly in high-risk situations, and guidelines need to be updated. Trial registration number Australian New Zealand Clinical Trials Registry: ACTRN12610000887077. (Source: BMJ Open)
Source: BMJ Open - April 22, 2015 Category: Journals (General) Authors: MacIntyre, C. R., Seale, H., Dung, T. C., Hien, N. T., Nga, P. T., Chughtai, A. A., Rahman, B., Dwyer, D. E., Wang, Q. Tags: Open access, Infectious diseases Research Source Type: research

Pediatric Emergency Update: Lethality of Liquid Nicotine in E-Cigarettes
Emergency nurses must immediately consider liquid nicotine overdose in any child who has vomiting, seizures, or altered mental status. Additional signs and symptoms of nicotine overdose may include abnormal vital signs such as tachycardia, bradycardia, hypertension, hypotension, respiratory depression, respiratory distress, and shock. Oral discomfort, including copious secretions, may be present. (Source: Journal of Emergency Nursing: JEN)
Source: Journal of Emergency Nursing: JEN - April 22, 2015 Category: Nursing Authors: Patricia A. Normandin, Stacey A. Benotti Tags: Pediatric Update Source Type: research

Failed needle decompression of bilateral spontaneous tension pneumothorax
This case report presents a young male admitted with primary bilateral spontaneous tension pneumothorax and severe respiratory distress. This is an extremely rare condition. The patient was on the verge of hypoxic cardiac arrest and the attempted needle thoracocentesis was unsuccessful. Needle thoracocentesis in the midclavicular line of the second intercostal space is widely used and recommended as first‐line treatment of tension pneumothorax. Reviewing the literature, the procedure is not based on solid evidence. It has high failure rates and potentially serious complications. Alternatives to this approach are perhaps ...
Source: Acta Anaesthesiologica Scandinavica - April 21, 2015 Category: Anesthesiology Authors: P. T. Bach, C. Sølling Tags: Case Report Source Type: research

Regulation of B-Cell-Activating Factor Expression on the Basophil Membrane of Allergic Patients
Conclusions: Basophils from allergic and healthy subjects constitutively express membrane BAFF, which is not upregulated by IgE or specific allergens but by TLR-2 ligands (LTA-SA and β-1,3-glucan). Aspergillus fumigatus stimulation was able to upregulate BAFF expression on the basophils of sensitized asthmatic patients, but not via IgE-dependent mechanisms, since results did not differ between the patient and control groups. These findings suggest that basophils may contribute to the polyclonal production of IgE commonly observed in patients with SAFS and ABPA.Int Arch Allergy Immunol 2015;166:208-212 (Source: Internation...
Source: International Archives of Allergy and Immunology - April 21, 2015 Category: Allergy & Immunology Source Type: research

Nocturnal non-invasive positive pressure ventilation for COPD
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - April 21, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Importance of a multidisciplinary approach and monitoring in fetal warfarin syndrome
Warfarin is a synthetic oral anticoagulant that crosses the placenta and can lead to a number of congenital abnormalities known as fetal warfarin syndrome. Our aim is to report on the follow‐up from birth to age 8 years of a patient with fetal warfarin syndrome. He presented significant respiratory dysfunction, as well as dental and speech and language complications. The patient was the second child of a mother who took warfarin during pregnancy due to a metallic heart valve. The patient had respiratory dysfunction at birth. On physical examination, he had a hypoplastic nose, pectus excavatum, and clubbing of the fingers...
Source: American Journal of Medical Genetics Part A - April 21, 2015 Category: Genetics & Stem Cells Authors: Daniélle B. Silveira, Ernani B. da Rosa, Vinicius F. de Mattos, Thayse B. Goetze, Pricila Sleifer, Fernanda D. Santa Maria, Rosana C. M. Rosa, Rafael F. M. Rosa, Paulo R. G. Zen Tags: Clinical Report Source Type: research

Iatrogenic diaphragmatic hernia in paediatric patients
Conclusions Iatrogenic diaphragmatic hernia should be considered in differential diagnosis in paediatric patients presenting with intestinal obstruction or respiratory distress after hepatic resection or liver transplantation for early diagnosis and management. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - April 21, 2015 Category: Surgery Source Type: research

Huge Respiratory Epithelial Adenomatoid Hamartoma Originating from the Inferior Nasal Turbinate: A Case Report
We report a case of a 22-year-old male patient with 7-year history of nasal obstruction and headache resulting from a huge left-sided nasal lesion. Computed tomography, magnetic resonance and biopsy were performed to make a provisional diagnosis of REAH originating from the left-sided inferior turbinate. The definitive diagnosis of REAH was made by histopathological examination of the removed mass. We also discuss the origin and differential diagnosis of these rare lesions. (Source: Indian Journal of Otolaryngology and Head and Neck Surgery)
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - April 21, 2015 Category: ENT & OMF Source Type: research

Accuracy of CO 2 monitoring via nasal cannulas and oral bite blocks during sedation for esophagogastroduodenoscopy
Abstract Esophagogastroduodenoscopy procedures are typically performed under conscious sedation. Drug-induced respiratory depression is a major cause of serious adverse effects during sedation. Capnographic monitoring of respiratory activity improves patient safety during procedural sedation. This bench study compares the performance of the nasal cannulas and oral bite blocks used to monitor exhaled CO2 during sedation. We used a spontaneously breathing mechanical lung to evaluated four CO2 sampling nasal cannulas and three CO2 sampling bite blocks. We placed pneumatic resistors in the mouth of the manikin to ...
Source: Journal of Clinical Monitoring and Computing - April 21, 2015 Category: Information Technology Source Type: research

Pharmacological characterization of the interaction between the dual phosphodiesterase (PDE) 3/4 inhibitor RPL554 and glycopyrronium on human isolated bronchi and small airways
Conclusions RPL554 and glycopyrronium demonstrated a synergistic interaction in relaxing both human medium and small isolated bronchi, in terms of peak relaxation and an extended duration of action, suggesting that this combination may have a beneficial role in the treatment of asthma or COPD. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 21, 2015 Category: Respiratory Medicine Source Type: research

US Environmental Protection Agency sued over toxic air pollutants
Publication date: Available online 20 April 2015 Source:The Lancet Respiratory Medicine Author(s): Roxanne Nelson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 21, 2015 Category: Respiratory Medicine Source Type: research

Muscle imaging data in late-onset Pompe disease reveal a correlation between the pre-existing degree of lipomatous muscle alterations and the efficacy of long-term enzyme replacement therapy
Conclusions The results demonstrate that fatty muscle degeneration can occur before clinical manifestation of muscle weakness and suggest that mildly affected muscles may respond better to ERT treatment than severely involved muscles. If these findings can be validated by further studies, it should be discussed if muscle alterations detected by muscle MRI may be an objective sign of disease manifestation justifying an early start of ERT in clinically asymptomatic patients in order to improve the long-term outcome. (Source: Molecular Genetics and Metabolism Reports)
Source: Molecular Genetics and Metabolism Reports - April 21, 2015 Category: Genetics & Stem Cells Source Type: research

A pressure-driven column-based technique for the efficient extraction of DNA from respiratory samples
In this study, the pressure system extracting DNA in column-based kit was developed, and its utility was compared with the centrifuge method using sputum from patients who were diagnosed with pneumonia. Also, due to the compact size and rapid processing time, the practical application of the pressure-based system incorporated into an automated pipetting machine was evaluated through clinical study. Our data suggests that DNA extraction by pressure was capable of serving as a substitute for the centrifuge method, and the compact and automatic nature of the pressure system device provided rapid and valuable information for c...
Source: Clinica Chimica Acta - April 21, 2015 Category: Laboratory Medicine Source Type: research

The effect of two different doses of remifentanil on postoperative pain and opioid consumption after cardiac surgery – a randomized controlled trial
ConclusionsRemifentanil 0.3 μg/kg/min infusion did not increase postoperative pain or opioid consumption after cardiac surgery compared to the 0.1 μg/kg/min infusion. Remifentanil infusion 0.1–0.3 μg/kg/min during cardiac surgery was safe, with no exaggerated postoperative pain or opioid consumption. (Source: Acta Anaesthesiologica Scandinavica)
Source: Acta Anaesthesiologica Scandinavica - April 21, 2015 Category: Anesthesiology Authors: P. Florkiewicz, T. Musialowicz, O. Pitkänen, P. Lahtinen Tags: Original Article Source Type: research

Fever and back pain with abdominal aorta tenderness: Takayasu arteritis
In November 2010, a 27-year-old woman was referred with a 2-month history of fever and pain in a palm-sized area at the T10–12 vertebral level that was not aggravated by trunk movement, inspiration, or eating. She denied gastrointestinal symptoms, bladder irritation, or vaginal discharge changes. Her medical history included migraine and pyelonephritis. Physical examination revealed a body temperature of 38·4°C, blood pressure of 118/62 mmHg, pulse rate of 104 beats/min, and normal head, neck, and respiratory findings. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 21, 2015 Category: Journals (General) Authors: Kiyoshi Shikino, Shingo Suzuki, Kazutaka Noda, Yoshiyuki Ohira, Masatomi Ikusaka Tags: Clinical Communication to the Editor Source Type: research

Efficacy of idebenone on respiratory function in patients with Duchenne muscular dystrophy not using glucocorticoids (DELOS): a double-blind randomised placebo-controlled phase 3 trial
This study is registered with ClinicalTrials.gov, number NCT01027884. Findings 31 patients in the idebenone group and 33 in the placebo group comprised the ITT population, and 30 and 27 comprised the mITT population. Idebenone significantly attenuated the fall in PEF%p from baseline to week 52 in the mITT (−3·05%p [95% CI −7·08 to 0·97], p=0·134, vs placebo −9·01%p [–13·18 to −4·84], p=0·0001; difference 5·96%p [0·16 to 11·76], p=0·044) and ITT populations (−2·57%p [–6·68 to 1·54], p=0·215, vs −8·84%p [–12·73 to −4·95], p<0·0001; difference 6·27%p [0·61 to 11·93], p=0·031...
Source: The Lancet - April 21, 2015 Category: Journals (General) Source Type: research

Astragalin inhibits autophagy-associated airway epithelial fibrosis
Conclusion: These results demonstrate that astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inhibiting autophagosome formation in airways. (Source: Respiratory Research)
Source: Respiratory Research - April 21, 2015 Category: Respiratory Medicine Authors: In-Hee ChoYean-Jung ChoiJu-Hyun GongDaekeun ShinMin-Kyung KangYoung-Hee Kang Source Type: research

Reply to correspondence regarding the paper “Ternesten-Hasséus E, Johansson EL, Millqvist E. Cough reduction using capsaicin. Respir Med. 2015 Jan;109(1):27–37.”
We are thankful for the interesting points of view and the discussion regarding our article, recently published in Respiratory Medicine[1]. The authors point out a possible mechanism behind our results, which demonstrated that pure capsaicin, taken orally, improved both cough symptoms and capsaicin cough sensitivity in patients with chronic cough. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 21, 2015 Category: Respiratory Medicine Tags: Letter to the Editor Source Type: research

A severe congenital myasthenic syndrome with ‘dropped head' caused by novel MUSK mutations
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - April 21, 2015 Category: Internal Medicine Authors: Miriam L. Giarrana, Pascal Joset, Heinrich Sticht, Stephanie Robb, Katharina Steindl, Anita Rauch, Andrea Klein Tags: Case of the Month Source Type: research

Phenotypic variation of TTC19‐deficient mitochondrial complex III deficiency: A case report and literature review
We report on an 8‐year‐old girl born to consanguineous Iraqi parents presenting with slowly progressive encephalomyopathy, severe failure to thrive, significant delays in verbal and communicative skills and bilateral retinal cherry red spots on fundoscopy. SNP array identified multiple regions of homozygosity involving 7.5% of the genome. Mutations in the TTC19 gene are known to cause complex III deficiency and TTC19 was located within the regions of homozygosity. Sequencing of TTC19 revealed a homozygous nonsense mutation at exon 6 (c.937C > T; p.Q313X). We reviewed the phenotypes and genotypes of all 11 patien...
Source: American Journal of Medical Genetics Part A - April 21, 2015 Category: Genetics & Stem Cells Authors: Dylan A. Mordaunt, Alexandra Jolley, Shanti Balasubramaniam, David R. Thorburn, Hayley S. Mountford, Alison G. Compton, Jillian Nicholl, Nicholas Manton, Damian Clark, Drago Bratkovic, Kathryn Friend, Sui Yu Tags: Research Article Source Type: research

Atypical fibrodysplasia ossificans progressiva diagnosed by whole‐exome sequencing
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification of connective tissue that begins during the first decade of life. Our patient presented with intrauterine growth retardation, respiratory distress, neonatal onset soft tissue masses, bilateral hallux valgus, and congenital anomalies of the thyroid and uterus. She was initially diagnosed with atypical infantile myofibromatosis based on clinical and pathological findings. She underwent whole‐exome sequencing (WES) as part of the FORGE study to identify t...
Source: American Journal of Medical Genetics Part A - April 21, 2015 Category: Genetics & Stem Cells Authors: Hao Liu, Sarah L Sawyer, Monika Gos, David Grynspan, Kheirie Issa, Raveena Ramphal, Carmen Rotaru, FORGE Canada Consortium, Jacek Majewski, Kym M Boycott, Gail Graham, Matthew Bromwich Tags: Clinical Report Source Type: research

Clinical and molecular characterization of an infant with a tandem duplication and deletion of 19p13
We present a patient with a tandem de novo 3.9 Mb duplication of 19p13.12p13.2 and an adjacent 288 kb deletion of 19p13.12. The CNVs were detected by genome wide SNP‐array and confirmed by fluorescence in situ hybridization. Mate‐pair sequencing revealed two breakpoint junctions leading to a germline tandem inverted duplication and an adjacent deletion. The patient had a major congenital heart defect and refractory edema leading to metabolic and endocrinological disturbances. Further complications occurred due to refractory chylothorax, severe inflammatory response syndrome, and repeating sepsis. After 2 months, th...
Source: American Journal of Medical Genetics Part A - April 21, 2015 Category: Genetics & Stem Cells Authors: Ratna N. G. B. Tan, Ruben S. G. M. Witlox, Yvonne Hilhorst‐Hofstee, Cacha M. P. C. D. Peeters‐Scholte, Nicolette S. den Hollander, Claudia A. L. Ruivenkamp, Mariëtte J.V. Hoffer, Kerstin B. Hansson, Mark J. van Roosmalen, Wigard P. Kloosterman, Gijs Tags: Clinical Report Source Type: research

Structure of CARDS toxin from M. pneumoniae [Microbiology]
Mycoplasma pneumoniae (Mp) infections cause tracheobronchitis and “walking” pneumonia, and are linked to asthma and other reactive airway diseases. As part of the infectious process, the bacterium expresses a 591-aa virulence factor with both mono-ADP ribosyltransferase (mART) and vacuolating activities known as Community-Acquired Respiratory Distress Syndrome Toxin (CARDS TX). CARDS... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 21, 2015 Category: Science Authors: Becker, A., Kannan, T. R., Taylor, A. B., Pakhomova, O. N., Zhang, Y., Somarajan, S. R., Galaleldeen, A., Holloway, S. P., Baseman, J. B., Hart, P. J. Tags: Biological Sciences Source Type: research

Risk Factors for Hospitalization Due to Community-Acquired Sepsis – A Population-Based Case-Control Study
Conclusions Hospitalization due to sepsis of any severity was associated with several independent risk factors, including age and comorbid factors. (Source: PLoS One)
Source: PLoS One - April 21, 2015 Category: Biomedical Science Authors: Daniel Pilsgaard Henriksen et al. Source Type: research

Angiogenic Factors in Cord Blood of Preterm Infants Predicts Subsequently Developing Bronchopulmonary Dysplasia
Conclusion Cord blood level of PlGF, rather than VEGF or sFlt-1, was significantly increased in the BPD group. Consistent with our previous report, cord blood level of PlGF may be considered as a biomarker to predict subsequently developing BPD in preterm infants. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - April 21, 2015 Category: Perinatology & Neonatology Source Type: research

Association between respiratory infections in early life and later asthma is independent of virus type
Lower respiratory tract infections in the first years of life are associated with later asthma, and this observation has led to a focus on the potential causal role of specific respiratory viruses, such as rhinoviruses and respiratory syncytial virus, in asthma development. However, many respiratory viruses and bacteria trigger similar respiratory symptoms and it is possible that the important risk factors for asthma are the underlying susceptibility to infection and the exaggerated reaction to such triggers rather than the particular triggering agent. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - April 21, 2015 Category: Allergy & Immunology Authors: Klaus Bønnelykke, Nadja Hawwa Vissing, Astrid Sevelsted, Sebastian L. Johnston, Hans Bisgaard Source Type: research

Eight Hours of Nightly CPAP Treatment of Obstructive Sleep Apnea Improves Glucose Metabolism in Prediabetes: A Randomized Controlled Trial.
CONCLUSIONS: In prediabetics, 8-hour nightly CPAP treatment for 2-weeks improves glucose metabolism, as compared to placebo. Thus, CPAP treatment may be beneficial for metabolic risk reduction. Clinical trial registration available at www.clinicaltrials.gov, ID NCT01156116. PMID: 25897569 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 21, 2015 Category: Respiratory Medicine Authors: Pamidi S, Wroblewski K, Stepien M, Sharif-Sidi K, Kilkus J, Whitmore H, Tasali E Tags: Am J Respir Crit Care Med Source Type: research

The Plant Derivative Compound A Inhibits the Production of Corticosteroid-resistant Chemokines by Airway Smooth Muscle Cells.
Abstract Preclinical models of human conditions including asthma showed the therapeutic potential of compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not been addressed. We investigated whether CpdA modulates cytokine-induced GC resistance in human airway smooth muscle (ASM) cells. Healthy and asthmatic ASM cells were treated with TNFα/IFNγ for 24 hr in the presence or absence of CpdA. ELISA and qPCR assays were used to assess the effect of CpdA on chemokine expression. Activation of GRα by CpdA was assessed ...
Source: Am J Respir Cell Mol... - April 21, 2015 Category: Respiratory Medicine Authors: Gavrila A, Chachi L, Tliba O, Brightling C, Amrani Y Tags: Am J Respir Cell Mol Biol Source Type: research

Sensitization Can Influence Mechanisms of Organophosphorus Pesticide-Induced Airway Hyperreactivity.
Abstract We previously demonstrated that antigen sensitization increases vulnerability to airway hyperreactivity induced by the organophosphorus pesticide (OP) parathion. Sensitization also changes the mechanism of parathion-induced airway hyperreactivity to one that is dependent on interleukin-5 (IL5). To determine whether this effect can be generalized to other OPs, and to other classes of pesticides, we measured airway responsiveness to vagal stimulation or intravenous acetylcholine in non-sensitized and ovalbumin-sensitized guinea pigs 24 h after a single subcutaneous injection of the OPs diazinon or chlorpyrif...
Source: Am J Respir Cell Mol... - April 21, 2015 Category: Respiratory Medicine Authors: Proskocil BJ, Bruun DA, Garg JA, Villagomez CC, Jacoby DB, Lein PJ, Fryer AD Tags: Am J Respir Cell Mol Biol Source Type: research

Review: In acute respiratory failure, prehospital CPAP reduces mortality and intubation rates.
PMID: 25894050 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 21, 2015 Category: Internal Medicine Authors: Sen A Tags: Ann Intern Med Source Type: research

A comprehensive assessment of genioglossus electromyographic activity in healthy adults
The genioglossus (GG) is an extrinsic muscle of the human tongue that plays a critical role in preserving airway patency. In the last quarter century, >50 studies have reported on respiratory-related GG electromyographic (EMG) activity in human subjects. Remarkably, of the studies performed, none have duplicated subject body position, electrode recording locations, and/or breathing task(s), making interpretation and integration of the results across studies extremely challenging. In addition, more recent research assessing lingual anatomy and muscle contractile properties has identified regional differences in muscle fi...
Source: Journal of Neurophysiology - April 21, 2015 Category: Neurology Authors: Vranish, J. R., Bailey, E. F. Tags: Control Of Movement Source Type: research

Carotid body over activity induces respiratory neurone channelopathy contributing to neurogenic hypertension.
This article is protected by copyright. All rights reserved. PMID: 25900825 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 21, 2015 Category: Physiology Authors: Moraes DJ, Machado BH, Paton JF Tags: J Physiol Source Type: research

The RECITE Study: A Canadian Prospective, Multicenter Study of the Incidence and Severity of Residual Neuromuscular Blockade.
CONCLUSIONS: Residual paralysis is common at tracheal extubation and PACU arrival, despite qualitative neuromuscular monitoring and the use of neostigmine. More effective detection and management of NMB is needed to reduce the risks associated with residual NMB. PMID: 25902322 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - April 21, 2015 Category: Anesthesiology Authors: Fortier LP, McKeen D, Turner K, de Médicis É, Warriner B, Jones PM, Chaput A, Pouliot JF, Galarneau A Tags: Anesth Analg Source Type: research

The Whitening of Brown Fat and Its Implications for Weight Management in Obesity
Abstract Systemic inflammation resulting from dysfunction of white adipose tissue (WAT) accelerates the pathologies of diabetes and cardiovascular diseases. In contrast to WAT, brown adipose tissue (BAT) is abundant in mitochondria that produce heat by uncoupling respiratory chain process of ATP synthesis. Besides BAT’s role in thermogenesis, accumulating evidence has shown that it is involved in regulating systemic metabolism. Studies have analyzed the “browning” processes of WAT as a means to combat obesity, whereas few studies have focused on the impact and molecular mechanisms that contribute to obesity-...
Source: Current Obesity Reports - April 20, 2015 Category: Eating Disorders and Weight Management Source Type: research

Cigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in mice.
CONCLUSIONS: These findings demonstrate that exposure to CS impacts the ability of the host to control bacterial colonization of the upper airways, resulting in enhanced inflammation and susceptibility of the host to pathogens migrating into the lung. PMID: 25890119 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2015 Category: Respiratory Medicine Authors: Voss M, Wonnenberg B, Honecker A, Kamyschnikow A, Herr C, Bischoff M, Tschernig T, Bals R, Beisswenger C Tags: Respir Res Source Type: research

National trends in emergency room diagnosis of pulmonary embolism, 2001-2010: a cross-sectional study.
CONCLUSIONS: The proportion of ED visits with a diagnosis of PE increased significantly from 2001 to 2010 and this rise can be attributed in large part to the increased availability and use of CT. Most of these patients were admitted with low in-hospital mortality. PMID: 25890024 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2015 Category: Respiratory Medicine Authors: Schissler AJ, Rozenshtein A, Schluger NW, Einstein AJ Tags: Respir Res Source Type: research

Anti-inflammatory effects of novel curcumin analogs in experimental acute lung injury.
CONCLUSIONS: These results suggest that the novel curcumin analog c26 has remarkable protective effects on LPS-induced ALI in rat. These effects may be related to its ability to suppress production of inflammatory cytokines through ERK pathway. Compound c26, with improved chemical stability and bioactivity, may have the potential to be further developed into an anti-inflammatory candidate for the prevention and treatment of ALI. PMID: 25889862 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 20, 2015 Category: Respiratory Medicine Authors: Zhang Y, Liang D, Dong L, Ge X, Xu F, Chen W, Dai Y, Li H, Zou P, Yang S, Liang G Tags: Respir Res Source Type: research