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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Icatibant, an inhibitor of bradykinin receptor 2, for hereditary angioedema attacks: prospective experimental single-cohort study.
CONCLUSION: HAE type I patients who received icatibant responded promptly; most achieved improved symptom severity within 30 minutes. Local adverse events occurred in 75% of the patients. PMID: 25054967 [PubMed - as supplied by publisher] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - July 22, 2014 Category: Journals (General) Authors: Campos RA, Valle SO, França AT, Cordeiro E, Serpa FS, Mello YF, Malheiros T, Toledo E, Mansour E, Fusaro G, Grumach AS Tags: Sao Paulo Med J Source Type: research

Spillover of Cytokines and Reactive Oxygen Species in Ventilator-Induced Lung Injury Associated With Inflammation and Apoptosis in Distal Organs.
CONCLUSIONS: High VT ventilation induces VILI and is associated with inflammation and apoptosis in distal organs. Up-regulation of reactive oxygen species and cytokines in VILI is associated with systemic inflammatory responses. Kidney tissue appears to be more vulnerable than heart and liver tissues following VILI. PMID: 25053831 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Liu YY, Chiang CH, Chuang CH, Liu SL, Jheng YH, Ryu JH Tags: Respir Care Source Type: research

Filamin A Mutation May Be Associated With Diffuse Lung Disease Mimicking Bronchopulmonary Dysplasia in Premature Newborns.
We present the clinical course of a premature newborn with a complicated neonatal respiratory course that was initially thought to be related to BPD, but it did not respond to the typical therapies for this condition. Due to the findings of periventricular nodular heterotopia, the diagnosis of a filamin A gene mutation was eventually made, which explained the respiratory pathology of this patient. When time of onset and clinical course do not correlate with typical BPD, one should consider alternative diagnoses in premature infants, including neonatal diffuse lung disease. PMID: 25053830 [PubMed - as supplied by publis...
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Lord A, Shapiro AJ, Saint-Martin C, Claveau M, Melançon S, Wintermark P Tags: Respir Care Source Type: research

Unilateral Hyperlucent Lung Associated With Bronchial Atresia Mimicking Swyer-James Syndrome.
PMID: 25053829 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Ando M, Miyazaki E, Fujisaki H, Nureki SI, Kadota JI Tags: Respir Care Source Type: research

Respiratory Failure Secondary to Relapsing Polychondritis.
PMID: 25053828 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 22, 2014 Category: Respiratory Medicine Authors: Badireddi S, Siddiqui MF, Boddu NJ Tags: Respir Care Source Type: research

Comparison of respiratory muscles activity and exercise capacity in patients with idiopathic scoliosis and healthy individuals.
Conclusions: Scoliosis causes respiratory muscle weakness and reduced fatigue duration in response to mild physical activity compared with healthy subjects and these dysfunctions appear to be related to the severity of scoliosis curvature (moderate > mild). PMID: 25051355 [PubMed - as supplied by publisher] (Source: Physiotherapy Theory and Practice)
Source: Physiotherapy Theory and Practice - July 22, 2014 Category: Physiotherapy Authors: Mohammadi P, Akbari M, Sarrafzadeh J, Moradi Z Tags: Physiother Theory Pract Source Type: research

Enhanced production techniques, properties and uses of coenzyme Q10.
Abstract Coenzyme Q10 (CoQ10) is an essential component of the respiratory chain which produces ATP. It is formed from the conjugation of a benzoquinone ring with a hydrophobic isoprenoid chain. Efforts on the production of CoQ10 by microorganisms focus on the development of potent strains by conventional mutagenesis and metabolic engineering especially in Escherichia coli, analysis and modification of the key metabolic pathways and optimization of fermentation strategies. CoQ10 has excellent antioxidant properties and is beneficial in the treatment of several human diseases. The present review covers the current s...
Source: Biotechnology Letters - July 22, 2014 Category: Biotechnology Authors: de Dieu Ndikubwimana J, Lee BH Tags: Biotechnol Lett Source Type: research

Permianibacter aggregans gen. nov., sp. nov., a novel bacterium of the family Pseudomonadaceae capable of aggregating potential biofuel-producing microalgae.
Abstract A novel bacterial strain, capable of aggregating potential biofuel-producing microalgae, was isolated from the phycosphere of an algal culture and designated as HW001T. The novel bacterial strain was identified on the basis of its phylogenetic, genotypic chemotaxonomic and phenotypic characteristics in this study. Cells are aerobic, Gram-negative rods. 16S rRNA gene-based phylogenetic analysis revealed that HW001T is affiliated with the family Pseudomonadaceae in the phylum Proteobacteria, but forms a distinct clade within this family. The DNA G+C content of the strain HW001T is 55.4 mol%. The predominant ...
Source: International Journal of Systematic and Evolutionary Microbiology - July 22, 2014 Category: Microbiology Authors: Wang H, Zheng T, Hill R, Hu X Tags: Int J Syst Evol Microbiol Source Type: research

Phaeodactylibacter xiamenensis gen. nov., sp. nov., a member of the family Saprospiraceae isolated from the marine algae Phaeodactylum tricornutum .
Abstract A novel Gram-staining-negative, aerobic, rod-shaped, non-motile bacterium, reddish orange-coloured, and chemoheterotrophic bacteria designated strain KD52T, was isolated from a culture of the alga Phaeodactylum tricornutum, Xiamen, Fujian Province, China. 16S rRNA gene sequence comparison showed that strain KD52T was a member of the family Saprospiraceae, forming a distinct lineage with Portibacter lacus KCTC 23747T . The 16S rRNA gene sequence similarity between strain KD52T and the type strains of Saprospiraceae species ranged from 86% to 89%. Growth occurred at 20-37°C (optimum, 28°C), in the presence...
Source: International Journal of Systematic and Evolutionary Microbiology - July 22, 2014 Category: Microbiology Authors: Chen Z, Lei X, Lai Q, Li Y, Zhang B, Zhang J, Zhang H, Yang L, Zheng W, Tian Y, Yu Z, Xu H, Zheng T Tags: Int J Syst Evol Microbiol Source Type: research

Respiratory glycerol metabolism of Actinobacillus succinogenes 130Z for succinate production.
Abstract Actinobacillus succinogenes 130Z naturally produces among the highest levels of succinate from a variety of inexpensive carbon substrates. A few studies have demonstrated that A. succinogenes can anaerobically metabolize glycerol, a waste product of biodiesel manufacture and an inexpensive feedstock, to produce high yields of succinate. However, all these studies were performed in the presence of yeast extract, which largely removes the redox constraints associated with fermenting glycerol, a highly reduced molecule. We demonstrated that A. succinogenes cannot ferment glycerol in minimal medium, but that i...
Source: Journal of Industrial Microbiology and Biotechnology - July 22, 2014 Category: Microbiology Authors: Schindler BD, Joshi RV, Vieille C Tags: J Ind Microbiol Biotechnol Source Type: research

Exercise alters liver mitochondria phospholipidomic profile and mitochondrial activity in non-alcoholic steatohepatitis.
Abstract Mitochondrial membrane lipid composition is a critical factor in non-alcoholic steatohepatitis (NASH). Exercise is the most prescribed therapeutic strategy against NASH and a potential modulator of lipid membrane. Thus, we aimed to analyze whether physical exercise exerted preventive (voluntary physical activity-VPA) and therapeutic (endurance training-ET) effect on NASH-induced mitochondrial membrane changes. Sprague-Dawley rats (n=36) were divided into standard-diet sedentary (SS, n=12), standard-diet VPA (SVPA, n=6), high-fat diet sedentary (HS, n=12) and high-fat diet VPA (HVPA, n=6). After 9 weeks of ...
Source: The International Journal of Biochemistry and Cell Biology - July 22, 2014 Category: Biochemistry Authors: Gonçalves IO, Maciel E, Passos E, Torrella JR, Rizo D, Viscor G, Rocha-Rodrigues S, Santos-Alves E, Domingues MR, Oliveira PJ, Ascensão A, Magalhães J Tags: Int J Biochem Cell Biol Source Type: research

The glucose RQ-feedback control leading to improved erythromycin production by a recombinant strain Saccharopolyspora erythraea ZL1004 and its scale-up to 372-m(3) fermenter.
Abstract In this paper, glucose respiratory quotient (RQ)-feedback control was developed for erythromycin production with a recombinant strain Saccharopolyspora erythraea ZL1004. RQ was confirmed to be an ideal online parameter for regulating glucose feed rate. Through feeding glucose to control RQ at 0.85 during 45-100 h and 0.95 during 100-185 h, erythromycin titer and erythromycin A concentration were reached 11.88 and 8.82 g l(-1) in 50 l fermenter, which were increased by 8.3 and 6.1 % as compared to that with glucose pH-feedback control, respectively. When glucose RQ-feedback control was scaled up to 37...
Source: Bioprocess and Biosystems Engineering - July 22, 2014 Category: Biomedical Engineering Authors: Chen Y, Wang Z, Chu J, Xi B, Zhuang Y Tags: Bioprocess Biosyst Eng Source Type: research

Modulation of immune responses by immunotherapy in allergic diseases.
Abstract Allergen immunotherapy (AIT) has been used for 100 years and until now different immunoregulatory pathways have been shown to take place in its mechanisms of action. It is characterized by administration of the causative allergen and is shown to be clinically efficient even after discontinuation of therapy particularly in allergic respiratory diseases, bee venom allergy, and food allergy. Generation of antigen/allergen-specific peripheral tolerance is the key mechanism during immunotherapy. It is mediated by development of T and B regulatory cells, IgG4 isotype allergen-specific antibodies and the involvem...
Source: Current Opinion in Pharmacology - July 22, 2014 Category: Drugs & Pharmacology Authors: Cavkaytar O, Akdis CA, Akdis M Tags: Curr Opin Pharmacol Source Type: research

Deficits in neuronal cytochrome P450 activity attenuate, Opioid Analgesia but not Opioid Side Effects.
Abstract Morphine-like analgesics act on µ opioid receptors in the CNS to produce highly effective pain relief, but the same class of receptors also mediates non-therapeutic side effects. The analgesic properties of morphine were recently shown to require the activity of a brain neuronal cytochrome P450 epoxygenase, but the significance of this pathway for opioid side effects is unknown. Here we show that brain P450 activity is not required for three of morphine's major side effects (respiratory depression, constipation, and locomotor stimulation). Following systemic or intracerebroventricular administration of mo...
Source: European Journal of Pharmacology - July 22, 2014 Category: Drugs & Pharmacology Authors: Hough LB, Nalwalk JW, Cleary RA, Phillips JG, Fang C, Yang W, Ding X Tags: Eur J Pharmacol Source Type: research

The genomic and seroprevalence of human bocavirus in healthy Chinese plasma donors and plasma derivatives.
CONCLUSION: Low levels of HBoV DNA were detectable at high prevalence in Chinese plasma donors and plasma derivatives. Further study is needed to determine whether HBoV screening is necessary. PMID: 25052026 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - July 22, 2014 Category: Hematology Authors: Li H, He M, Zeng P, Gao Z, Bian G, Yang C, Li W Tags: Transfusion Source Type: research

Novel interactive effects of darkness and retinoid signaling in the ability to form long-term memory following aversive operant conditioning.
In this study, animals were exposed to constant darkness in order to test whether light-sensitive retinoic acid would promote memory formation. However, we found that exposure to constant darkness alone (in the absence of retinoic acid) enhanced memory formation. To determine whether the memory-promoting effects of darkness could override the memory-inhibiting effects of the retinoid signaling inhibitors, we exposed snails to RALDH inhibitors or a retinoid receptor antagonist in constant darkness. We found that darkness overcame the inhibitory effects of RALDH inhibition, but did not overcome the inhibitory effects of the ...
Source: Neurobiology of Learning and Memory - July 22, 2014 Category: Neurology Authors: Rothwell CM, Simmons J, Peters G, Spencer GE Tags: Neurobiol Learn Mem Source Type: research

Administration of supplemental L-tyrosine with phenelzine
Hinz M, Stein A, Cole T, Ryan P (Source: International Journal of COPD)
Source: International Journal of COPD - July 21, 2014 Category: Respiratory Medicine Source Type: research

Degree of extraversion and physiological responses to physical pain and sadness
Extraversion is a personality frequently discussed as one of the strongest and most consistent factors that relates to individual subjective wellbeing. The goal of this study was to better understand how people with varying degrees of extraversion psychologically and physiologically respond differently to unpleasant circumstances. Emotional responses (e.g., levels of intensity, valence, and arousal) were assessed in determining the sensitivity level to negative stimuli that were specifically designed to provoke physical pain and sadness emotion. Physiological changes (e.g., heart rate (HR), blood volume pulse (BVP), and re...
Source: Scandinavian Journal of Psychology - July 21, 2014 Category: Psychiatry & Psychology Authors: Mi‐Sook Park, Kyung Hwa Lee, Sunju Sohn, Jin‐Sup Eom, Jin‐Hun Sohn Tags: Personality and Social Psychology Source Type: research

Anti‐nociceptive and sedative effects of romifidine, tramadol and their combination administered intravenously slowly in ponies
ConclusionTramadol combined with romifidine at the stated doses proved an effective sedative and anti‐nociceptive combination in ponies, with no unacceptable behavioural or physiologic side effects. Clinical relevanceSlow controlled administration of tramadol should reduce the occurrence of adverse behavioural side effects. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Giovanna L Costa, Santo Cristarella, Marco Quartuccio, Claudia Interlandi Tags: Short Communication Source Type: research

Antinociceptive effect of buprenorphine and evaluation of the nociceptive withdrawal reflex in foals
Conclusion and clinical relevanceThese findings indicate that buprenorphine has antinociceptive effect in foals. Opioid side effects often recognized in adult horses also occur in foals. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Åse I Risberg, Claudia Spadavecchia, Birgit Ranheim, Eli HS Hendrickson, Andreas Lervik, Henning A Haga Tags: Research Paper Source Type: research

A comparison of cardiopulmonary function, recovery quality, and total dosages required for induction and total intravenous anesthesia with propofol versus a propofol‐ketamine combination in healthy Beagle dogs
Conclusions and clinical relevanceTotal intravenous anesthesia in healthy dogs with ketamine and propofol in a 1:1 mg mL−1 combination resulted in significant propofol dose reduction, higher HR, improved MAP, no difference in recovery quality, but more significant respiratory depression compared to propofol alone. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - July 21, 2014 Category: Veterinary Research Authors: Martin J Kennedy, Lesley J Smith Tags: Research Paper Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 21, 2014 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Assessment of two different types of bias affecting the results of outcome-based evaluation in undergraduate medical education
Conclusions: Given the small effect sizes, using thentests appears to be equivalent to using true pretest ratings. Item presentation in the posttest does not significantly impact on results. (Source: BMC Medical Education)
Source: BMC Medical Education - July 21, 2014 Category: Universities & Medical Training Authors: Sarah SchiekirkaSven AndersTobias Raupach Source Type: research

Early sedation and clinical outcomes of mechanically ventilated patients: a prospective multicenter cohort study
Conclusions: Early deep sedation is associated with adverse outcomes and constitutes an independent predictor of hospital mortality in mechanically ventilated patients. (Source: Critical Care)
Source: Critical Care - July 21, 2014 Category: Intensive Care Authors: Lilian TanakaLuciano AzevedoMarcelo ParkGuilherme SchettinoAntonio NassarAlvaro Réa-NetoLuana TannousVicente de Souza-DantasAndré TorellyThiago LisboaClaudio PirasFrederico CarvalhoMarcelo MaiaFabio GianiniFlavia MachadoFelipe Dal-PizzolAlexandre de Car Source Type: research

Physiological response to the 6-minute walk test in chronic heart failure patients versus healthy control subjects
Conclusions Above 500 m, 6MWD becomes less sensitive to any increase in peakVO2. Furthermore, CHF patients and healthy control subjects exercise respectively at maximal and high VO2, but below the anaerobic threshold (as assessed by a CPET) during the 6-min walk test. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - July 21, 2014 Category: Cardiology Authors: Deboeck, G., Muylem, A. V., Vachiery, J. L., Naeije, R. Tags: Original scientific paper Source Type: research

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research

Suboptimal nutrition in moderately preterm infants
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Kelly Brown, Mark J. Johnson, Alison A. Leaf Tags: Short Communication Source Type: research

Re: Tramadol can selectively manage moderate pain in children following European advice limiting codeine use
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Hossein Hassanian‐Moghaddam Tags: Letter Source Type: research

Tiotropium versus placebo for chronic obstructive pulmonary disease.
CONCLUSIONS: This review shows that tiotropium treatment was associated with a significant improvement in patients' quality of life and it reduced the risk of exacerbations, with a number needed to treat to benefit (NNTB) of 16 to prevent one exacerbation. Tiotropium also reduced exacerbations leading to hospitalisation but no significant difference was found for hospitalisation of any cause or mortality. Thus, tiotropium appears to be a reasonable choice for the management of patients with stable COPD, as proposed in guidelines. The trials included in this review showed a difference in the risk of mortality when compared ...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Karner C, Chong J, Poole P Tags: Cochrane Database Syst Rev Source Type: research

Endovascular treatment for ruptured abdominal aortic aneurysm.
CONCLUSIONS: The conclusions of this review are currently limited by the paucity of data. From the data available there is no difference in the outcomes evaluated in this review between eEVAR and open repair, specifically 30-day mortality. Not enough information was provided for complications in order to make a well informed conclusion at this time. Long-term data are lacking for both survival and late complications. More high quality, randomised controlled trials comparing eEVAR and open repair for the treatment of RAAA are needed in order to better understand if one method is superior to the other, or if there is no diff...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Badger S, Bedenis R, Blair PH, Ellis P, Kee F, Harkin DW Tags: Cochrane Database Syst Rev Source Type: research

Extracorporeal Life Support in Critically Ill Adults.
Abstract Extracorporeal life support (ECLS) has become increasingly popular as a salvage strategy for critically ill adults. Major advances in technology and the severe acute respiratory distress syndrome (ARDS) that characterized the 2009 influenza A (H1N1) pandemic have stimulated renewed interest in the use of veno-venous extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) to support the respiratory system. Theoretical advantages of ECLS for respiratory failure include the ability to rest the lungs by avoiding injurious mechanical ventilator settings and the potential to...
Source: American Journal of Respiratory and Critical Care Medicine - July 21, 2014 Category: Respiratory Medicine Authors: Ventetuolo CE, Muratore CS Tags: Am J Respir Crit Care Med Source Type: research

Sphingobacterium paludis sp. nov., isolated from wetland soil.
Abstract A novel Gram-negative bacteria, designated S37(T), was isolated from soil of the Xixi wetland, Zhejiang province, China. Cells of strain S37(T) were aerobic, non-motile rods. Growth occurred at 10-37 °C (optimum, 25 °C), pH 5.0-9.7 (optimum, pH 7.5) and with 0-6% (w/v) NaCl (optimum, 0.5%). Based on 16S rRNA gene sequence analysis, strain S37(T) was found to be a member of the genus Sphingobacterium and shared highest similarity with S.composti 4M24(T) (95.78%). The major fatty acids were summed feature 3 (iso-C15:0 2-OH and/or C16:1ω7c), iso-C15:0 and iso-C17:0 3-OH and the G+C content was 43.8 mol%. T...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Feng H, Zeng Y, Huang Y Tags: Int J Syst Evol Microbiol Source Type: research

Tangfeifania diversioriginum gen. nov. sp. nov., a novel representative of the family Draconibacteriaceae.
Abstract A novel Gram-stain-negative, facultatively anaerobic, catalase- and oxidase-positive, non-motile and pink pigmented bacterium, designated G22T, was isolated from Gahai, a saltwater lake in Qinghai province, China. Optimal growth occurred at 33-35 °C, pH 7.0-7.5, and in the presence of 2-4% (w/v) of NaCl. The DNA G+C content was 40.0 mol%. The major polar lipids were phosphatidylethanolamine and three unknown lipids. The predominant cellular fatty acids were iso-C15:0, anteiso-C15:0, iso-C17:0 3OH and iso-C15:0 3OH and MK-7 was the main respiratory quinine. Phylogenetic analysis based on 16S rRNA sequences...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Liu QQ, Li XL, Rooney AP, Du ZJ, Chen GJ Tags: Int J Syst Evol Microbiol Source Type: research

Vulgatibacter incomptus gen. nov., sp. nov. and Labilithrix luteola gen. nov., sp. nov., two myxobacteria isolated from soil in Yakushima Island, and the description of Vulgatibacteraceae fam. nov., Labilitrichaceae fam. nov. and Anaeromyxobacteraceae fam. nov.
Abstract Two myxobacterial strains (designated B00001T and B00002T) were isolated from forest soil samples collected from Yakushima Island, Kagoshima, Japan. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains B00001T and B00002T formed independent branches within the suborder Cystobacterineae and Sorangiineae and were most closely related to Cystobacter armeniaca DSM14710T (90.4%) and Byssovorax cruenta DSM14553T (91.3%), respectively. Neither strain showed typical features of myxobacteria, such as bacteriolytic action or fruiting body formation, but both had high DNA G+C contents (66.3-68...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Yamamoto E, Muramatsu H, Nagai K Tags: Int J Syst Evol Microbiol Source Type: research

Home Ventilation Therapy in Obstructive Sleep Apnea-Hypopnea Syndrome.
Abstract Obstructive sleep apnea-hypopnea is a highly prevalent disease that is often underdiagnosed at present. It has a significant economic and social welfare impact, accounting for a large part of the resources assigned to home respiratory therapies. As part of the 2014 SEPAR Year of the Chronic Patient and Domiciliary Respiratory Care sponsored by the Spanish Society of Pulmonology and Thoracic Surgery, this article reviews the most recent publications on the indications and controversial issues in the treatment of sleep apnea, the latest evidence for indication of various positive pressure devices, and adjust...
Source: Archivos de Bronconeumologia - July 21, 2014 Category: Cardiovascular & Thoracic Surgery Authors: González Mangado N, Troncoso Acevedo MF, Gómez García T Tags: Arch Bronconeumol Source Type: research

Dropsy Outbreak in a Single Family in Punjab, India.
We report an outbreak that is unusual because of its gradual onset, clustering in a single family, and with major manifestation of gastrointestinal illness mimicking acute gastroenteritis, hence leading to delayed diagnosis and high mortality. Thus, the diagnosis of epidemic dropsy should be considered as a strong possibility when there is clustering of cases in a single family with on and off gastrointestinal symptoms of vomiting and diarrhea in a mustard oil consuming belt. PMID: 25048376 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 21, 2014 Category: Tropical Medicine Authors: Pvm L, Sharma A, Bhatia D, Tikoo K, Kumar R Tags: Am J Trop Med Hyg Source Type: research

Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors
Abstract Identifying neurons essential for the generation of breathing and related behaviors such as vocalisation is an important question for human health. The targeted loss of preBötzinger Complex (preBötC) glutamatergic neurons, including those that express high levels of somatostatin protein (SST neurons), eliminates normal breathing in adult rats. Whether preBötC SST neurons represent a functionally specialised population is unknown. We tested the effects on respiratory and vocal behaviors of eliminating SST neuron glutamate release by Cre‐Lox‐mediated genetic ablation of the vesicular glutamate transporter 2 ...
Source: European Journal of Neuroscience - July 20, 2014 Category: Neuroscience Authors: Srinivasan Tupal, Michael A. Rieger, Guang‐Yi Ling, Thomas J. Park, Joseph D. Dougherty, Ann K. Goodchild, Paul A. Gray Tags: Research Report Source Type: research

Motiliproteus sediminis gen. nov., sp. nov., isolated from coastal sediment.
Abstract A novel Gram-stain-negative, rod-to-spiral-shaped, oxidase- and catalase- positive and facultatively aerobic bacterium, designated HS6(T), was isolated from marine sediment of Yellow Sea, China. It can reduce nitrate to nitrite and grow well in marine broth 2216 (MB, Hope Biol-Technology Co., Ltd) with an optimal temperature for growth of 30-33 °C (range 12-45 °C) and in the presence of 2-3 % (w/v) NaCl (range 0.5-7 %, w/v). The pH range for growth was pH 6.2-9.0, with an optimum at 6.5-7.0. Phylogenetic analysis based on 16S rRNA gene sequences demonstrated that the novel isolate was 93.3 % similar...
Source: Antonie van Leeuwenhoek - July 20, 2014 Category: Microbiology Authors: Wang ZJ, Xie ZH, Wang C, Du ZJ, Chen GJ Tags: Antonie Van Leeuwenhoek Source Type: research

Lacinutrix jangbogonensis sp. nov., a psychrophilic bacterium isolated from Antarctic marine sediment and emended description of the genus Lacinutrix.
Abstract A Gram-negative, strictly aerobic, non-motile, rod-shaped and psychrophilic bacterial strain, PAMC 27137(T), was isolated from the marine sediment of the Ross Sea, Antarctica. Strain PAMC 27137(T) was observed to grow at 4-10 °C, at pH 6.5-7.5 and in the presence of 2.5-4.0 % (w/v) sea salts. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain PAMC 27137(T) belongs to the genus Lacinutrix showing the high similarities with Lacinutrix mariniflava JCM 13824(T) (97.6 %) and Lacinutrix algicola JCM 13825(T) (97.1 %). Genomic relatedness analyses based on the average nucleotide ...
Source: Antonie van Leeuwenhoek - July 20, 2014 Category: Microbiology Authors: Lee YM, Hwang CY, Lee I, Jung YJ, Cho Y, Baek K, Hong SG, Kim JH, Chun J, Lee HK Tags: Antonie Van Leeuwenhoek Source Type: research

Bacterioplanes sanyensis gen. nov., sp. nov., a PHB-accumulating bacterium isolated from a pool of Spirulina platensis cultivation.
Abstract A Gram-negative, poly-3-hydroxybutyrate-accumulating rod bacterium, strain GYP-2(T), was isolated from a pool of marine Spirulina platensis cultivation, Sanya, China. Growth was observed at 10-45 °C and pH 6-10 in the presence of 1-10 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the new isolate belonged to Gammaproteobacteria and displayed 93.8-95.3 % 16S rRNA gene sequences similarities to members of the genera Thalassolituus, Oleibacter, and Oceanobacter, but house-keeping gene gyrB (encode DNA gyrase beta subunit) demonstrated that the new isolate was distantly...
Source: Archives of Microbiology - July 20, 2014 Category: Microbiology Authors: Wang G, Jia Q, Li T, Dai S, Wu H, He H, Fan J, Xiang W, Li X Tags: Arch Microbiol Source Type: research

Oscillating devices for airway clearance in people with cystic fibrosis.
CONCLUSIONS: There was no clear evidence that oscillation was a more or less effective intervention overall than other forms of physiotherapy; furthermore there was no evidence that one device is superior to another. The findings from one study showing an increase in frequency of exacerbations requiring antibiotics whilst using an oscillating device compared to positive expiratory pressure may have significant resource implications. More adequately-powered long-term randomised controlled trials are necessary and outcomes measured should include frequency of exacerbations, patient preference, adherence to therapy and genera...
Source: Cochrane Database of Systematic Reviews - July 20, 2014 Category: Journals (General) Authors: Morrison L, Agnew J Tags: Cochrane Database Syst Rev Source Type: research

Genetic Characterization and Evolution of H1N1pdm09 after Circulation in a Swine Farm.
In this study we investigated the molecular evolution of A(H1N1)pdm09 virus identified in pigs reared in a single herd. Nasal swabs taken from pigs showing respiratory distress were tested for influenza type A and A(H1N1)pdm09 by real-time RT-PCR assays. Virus isolation from positive samples was attempted by inoculation of nasal swabs samples into specific pathogen free embryonated chicken eggs (ECE) and complete genome sequencing was performed on virus strains after replication on ECE or from original swab sample. The molecular analysis of hemagglutinin (HA) showed, in four of the swine influenza viruses under study, a un...
Source: Biomed Res - July 19, 2014 Category: Research Authors: Boni A, Vaccari G, Di Trani L, Zaccaria G, Alborali GL, Lelli D, Cordioli P, Moreno AM Tags: Biomed Res Int Source Type: research

Efficacy of Burnout Interventions in the Medical Education Pipeline.
CONCLUSIONS: There is a growing body of evidence-based interventions to mitigate burnout which can be used in the development of future programs. More research is needed to identify and intervene against burnout earlier in the medical education pipeline, including at the undergraduate level. PMID: 25034955 [PubMed - as supplied by publisher] (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - July 19, 2014 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma?
Abstract Despite current guidelines and the range of available treatments, over a half of patients with asthma continue to suffer from poor symptomatic control and remain at risk of future worsening. Although a number of non-pharmacological measures are crucial for good clinical management of asthma, new therapeutic controller medications will have a role in the future management of the disease. Several long-acting anticholinergic bronchodilators are under investigation or are available for the treatment of respiratory diseases, including tiotropium bromide, aclidinium bromide, glycopyrronium bromide, glycopyrrolat...
Source: Primary Care - July 19, 2014 Category: Primary Care Authors: Price D, Fromer L, Kaplan A, van der Molen T, Román-Rodríguez M Tags: NPJ Prim Care Respir Med Source Type: research

Maternal protein restriction alters VEGF signaling and decreases pulmonary alveolar in fetal rats.
In this study, we investigated the effects of protein malnutrition in utero on pulmonary alveolarization and vascular growth of the fetal lung and placentae. Pregnant rats were feed with an isocaloric low-protein diet (8% protein) until delivery. Placenta and fetal lungs were harvested on 20th day of gestation (term 21 days of gestation). Lung index (lung weight as a percentage of body weight), total DNA and protein, radial alveolar count, arteriolar wall thickness, lung maturity and angiogenic factor VEGF were assessed. The lung was hypoplastic in IUGR fetus, evidenced by reduction in lung weight, DNA and protein content....
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Liu X, Lin Y, Tian B, Miao J, Xi C, Liu C Tags: Int J Clin Exp Pathol Source Type: research