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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Serum Free Fatty Acid Biomarkers of Lung Cancer.
CONCLUSIONS: Serum fatty acids and their metabolites demonstrate good sensitivity and specificity for the identification of adenocarcinoma of the lung. PMID: 24743744 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 17, 2014 Category: Respiratory Medicine Authors: Liu J, Mazzone PJ, Cata JP, Kurz A, Bauer M, Mascha EJ, Sessler DI Tags: Chest Source Type: research

Applying new strategies for the national adaptation, updating and dissemination of trustworthy guidelines: Results from the Norwegian adaptation of the American College of Chest Physicians Evidence-based Guidelines on Antithrombotic Therapy and the Prevention of Thrombosis, 9th Edition.
CONCLUSION: New strategies for adapting, updating and disseminating trustworthy guidelines proved feasible and will provide Norwegian health care professionals and patients with up to date guidance tailored to national circumstances. PMID: 24743701 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 17, 2014 Category: Respiratory Medicine Authors: Kristiansen A, Brandt L, Agoritsas T, Akl EA, Berge E, Jacobsen AF, Granan LP, Halvorsen S, Guyatt G, Vandvik PO Tags: Chest Source Type: research

Identification of new bacterial and fungal pathogens on surveillance bronchoscopy prior to sinus surgery in patients with cystic fibrosis
ConclusionsSurveillance BALF cultures obtained prior to FESS identified bacterial and fungal pathogens not previously detected by sputum or OP swab cultures in a cohort of CF patients with chronic sinus disease. Moreover, the identification of these new pathogens altered clinical management in a small number of patients. Pediatr Pulmonol. 2014; 9999:1–7. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 16, 2014 Category: Respiratory Medicine Authors: Stephen Kirkby, Don Hayes, Margaret Ginn‐Pease, John Gatz, Clayton Ellis, Meredith Lind, Charles Elmaraghy, Nancy Ryan‐Wenger, Shahid I. Sheikh Tags: Original Article: Cystic Fibrosis Source Type: research

Association of group component genetic variations in COPD and COPD exacerbation in a Japanese population
ConclusionsGC variations may affect exacerbation susceptibility, possibly leading to COPD worsening and its progression. (Source: Respirology)
Source: Respirology - April 16, 2014 Category: Respiratory Medicine Authors: Takeo Ishii, Takashi Motegi, Koichiro Kamio, Akihiko Gemma, Kozui Kida Tags: Original Article Source Type: research

Prevalence of COPD
(Source: Respirology)
Source: Respirology - April 16, 2014 Category: Respiratory Medicine Authors: Katsunori Kagohashi, Hiroaki Satoh, Koichi Kurishima Tags: Correspondence Source Type: research

Reply
(Source: Respirology)
Source: Respirology - April 16, 2014 Category: Respiratory Medicine Authors: Yasuo Sekine Tags: Correspondence Source Type: research

Forthcoming Meetings
(Source: Respirology)
Source: Respirology - April 16, 2014 Category: Respiratory Medicine Tags: Forthcoming Meetings Source Type: research

Journal Statistics
(Source: Respirology)
Source: Respirology - April 16, 2014 Category: Respiratory Medicine Tags: Journal Statistics Source Type: research

Bifidobacterium breve and Lactobacillus rhamnosus treatment is as effective as budesonide at reducing inflammation in a murine model for chronic asthma
Conclusion: These findings show that Bifidobacterium breve M-16 V and Lactobacillus rhamnosus NutRes1 have strong anti-inflammatory properties that are comparable to budesonide and therefore may be beneficial in the treatment of chronic asthma. (Source: Respiratory Research)
Source: Respiratory Research - April 16, 2014 Category: Respiratory Medicine Authors: Seil SagarMary MorganSi ChenArjan VosJohan GarssenJeroen van BergenhenegouwenLouis BoonNiki GeorgiouAletta KraneveldGert Folkerts Source Type: research

Respiratory and sensory irritation symptoms among residents exposed to low-to-moderate air pollution from biodegradable wastes
& Lars P Christensen (Source: Journal of Exposure Science and Environmental Epidemiology)
Source: Journal of Exposure Science and Environmental Epidemiology - April 16, 2014 Category: Epidemiology Authors: Victoria Blanes-VidalJesper BælumJoel SchwartzPer LøfstrømLars P Christensen Tags: air pollution modeling waste animal respiratory health Source Type: research

Reduction of Infarct Size by the Therapeutic Protein TAT-Ndi1 In Vivo
In this study, TAT-conjugated Ndi1 and placebo-control protein were synthesized using a cell-free system. Mitochondrial uptake and functionality of TAT-Ndi1 were demonstrated in mitochondrial preparations from rat hearts after intraperitoneal administration of the protein. Rats were randomized to receive either TAT-Ndi1 or placebo protein, and 2 hours later all animals underwent 45-minute coronary artery occlusion followed by 2 hours of reperfusion. Infarct size was delineated by tetrazolium staining and normalized to the volume of at-risk myocardium, with all analysis conducted in a blinded manner. Risk region was compara...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Mentzer, R. M., Wider, J., Perry, C. N., Gottlieb, R. A. Tags: Experimental Study Source Type: research

Clinical Presentation Resembling Mucosal Disease Associated with ‘HoBi’‐like Pestivirus in a Field Outbreak
This report describes the clinical signs and provides a pathologic framework of an outbreak associated with at least two different ‘HoBi’‐like strains. Based on these observations, it appears that these atypical pestiviruses are most likely underdiagnosed in Brazilian cattle. (Source: Transboundary and Emerging Diseases)
Source: Transboundary and Emerging Diseases - April 16, 2014 Category: Veterinary Research Authors: M. N. Weber, A. C. S. Mósena, S. V. D. Simões, L. L. Almeida, C. R. M. Pessoa, R. F. Budaszewski, T. R. Silva, J. F. Ridpath, F. Riet‐Correa, D. Driemeier, C. W. Canal Tags: Original Article Source Type: research

Pharmacokinetic‐pharmacodynamic modelling of intravenous buprenorphine in conscious horses
Conclusions and clinical relevanceThe suitability of the use of buprenorphine for peri‐operative analgesia in the horse is supported by the present study. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - April 16, 2014 Category: Veterinary Research Authors: Emma J Love, Ludovic Pelligand, Polly M Taylor, Joanna C Murrell, John W Sear Tags: Research Paper Source Type: research

Cardiopulmonary effects during anaesthesia induced and maintained with propofol in acepromazine pre‐medicated donkeys
Conclusions and clinical relevanceAdministration of propofol by the continuous infusion rate for the maintenance of anaesthesia resulted in stable cardiopulmonary effects and could prove to be clinically useful in donkeys. (Source: Veterinary Anaesthesia and Analgesia)
Source: Veterinary Anaesthesia and Analgesia - April 16, 2014 Category: Veterinary Research Authors: Hadi Naddaf, Ali Baniadam, Abdolrahman Rasekh, Abdolmajid Arasteh, Soroush Sabiza Tags: Short Communication Source Type: research

The diversity of young adult wheeze: a cluster analysis in a longitudinal birth cohort
Conclusions and Clinical RelevanceYoung adult wheeze is diverse and can be classified into distinct clusters. More severe clusters merit attention and are associated with childhood onset, atopy, impaired lung function and in some, smoking. Smoking‐associated undiagnosed wheezers also merit recognition. Better understanding of young adult wheeze could facilitate better later adult respiratory health. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - April 16, 2014 Category: Allergy & Immunology Authors: R. J. Kurukulaaratchy, H. Zhang, A. Raza, V. Patil, W. Karmaus, S. Ewart, S. H. Arshad Tags: Original Article Source Type: research

Respiration phase‐locks to fast stimulus presentations: Implications for the interpretation of posterior midline “deactivations”
Abstract The posterior midline region (PMR)—considered a core of the default mode network—is deactivated during successful performance in different cognitive tasks. The extent of PMR‐deactivations is correlated with task‐demands and associated with successful performance in various cognitive domains. In the domain of episodic memory, functional MRI (fMRI) studies found that PMR‐deactivations reliably predict learning (successful encoding). Yet it is unclear what explains this relation. One intriguing possibility is that PMR‐deactivations are partially mediated by respiratory artifacts. There is evidence that th...
Source: Human Brain Mapping - April 16, 2014 Category: Neurology Authors: Willem Huijbers, Cyriel M.A. Pennartz, Ewa Beldzik, Aleksandra Domagalik, M. Vinck, Winnie F. Hofman, Roberto Cabeza, Sander M. Daselaar Tags: Research Article Source Type: research

Longterm follow-up in European respiratory health studies - patterns and implications
Conclusions: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Ane JohannessenGiuseppe VerlatoBryndis BenediktsdottirBertil ForsbergKarl FranklinThorarinn GislasonMathias HolmChrister JansonRain JögiEva LindbergFerenc MacsaliErnst OmenaasFrancisco RealEirunn SaureVivi SchlünssenTorben SigsgaardTrude SkorgeCecilie S Source Type: research

Swallowing transit times and valleculae residue in stable chronic obstructive pulmonary disease
Conclusions: Our study suggests that stable COPD patients may present physiological adaptations as a protective swallowing maneuver to avoid aspiration/penetration of pharyngeal contents. Moreover, valleculae residue cannot be seen as an isolated factor when trying to explain swallowing alterations in this population. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Rosane de Deus ChavesFernanda Chiarion SassiLaura Davison MangilliShri JayanthiAlberto CukierBruno ZilbersteinClaudia Furquim de Andrade Source Type: research

Inflammatory cytokines in pulmonary hypertension
Pulmonary hypertension is an "umbrella term" used for a spectrum of entities resulting in an elevation of the pulmonary arterial pressure. Clinical symptoms include dyspnea and fatigue which in the absence of adequate therapeutic intervention may lead to progressive right heart failure and death. The pathogenesis of pulmonary hypertension is characterized by three major processes including vasoconstriction, vascular remodeling and microthrombotic events. In addition accumulating evidence point to a cytokine driven inflammatory process as a major contributor to the development of pulmonary hypertension.This review summarize...
Source: Respiratory Research - April 16, 2014 Category: Respiratory Medicine Authors: Alexandra GrothBart VrugtMatthias BrockRudolf SpeichSilvia UlrichLars Huber Source Type: research

Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema.
CONCLUSIONS: The sGC-cGMP axis is perturbed by chronic exposure to CS. Treatment of COPD animal models with sGC stimulators can prevent CS-induced PH and emphysema. PMID: 24738736 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 16, 2014 Category: Respiratory Medicine Authors: Weissmann N, Lobo B, Pichl A, Parajuli N, Seimetz M, Puig-Pey R, Ferrer E, Peinado VI, Domínguez-Fandos D, Fysikopoulos A, Stasch JP, Ghofrani HA, Coll-Bonfill N, Frey R, Schermuly RT, García-Lucio J, Blanco I, Bednorz M, Tura-Ceide O, Tadele E, Brandes Tags: Am J Respir Crit Care Med Source Type: research

Mitochondrial Transfer of Induced Pluripotent Stem Cells-derived MSCs to Airway Epithelial Cells Attenuates Cigarette Smoke-induced Damage.
Abstract Transplantation of mesenchymal stem cells (MSCs) holds great promise in the repair of cigarette smoke (CS)-induced lung damage in chronic obstructive pulmonary disease (COPD). As cigarette smoke leads to mitochondrial dysfunction, we therefore aimed to investigate the potential benefit of mitochondrial transfer from human-induced pluripotent stem cell-derived mesenchymal stem cells (iPSC-MSCs) to CS-exposed airway epithelial cells in vitro and in vivo. Rats were exposed to 4% CS for one hour daily for 56 days. At day 29 and day 43, human iPSC-MSCs or adult bone marrow-MSCs (BM-MSCs) were administered intra...
Source: Am J Respir Cell Mol... - April 16, 2014 Category: Respiratory Medicine Authors: Li X, Zhang Y, Yeung SC, Liang Y, Liang X, Ding Y, Ip MS, Tse HF, Mak JC, Lian Q Tags: Am J Respir Cell Mol Biol Source Type: research

Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma
Vitamin D deficiency is prevalent among people with various immune‐mediated conditions, including autoimmune diseases and asthma. Serum 25(OH)D levels inversely correlate with asthma severity, glucocorticoid responsiveness/dosage, and markers of pathogenesis, such as airway remodeling, IgE, and eosinophilia. Trials involving supplementation with active vitamin D or a precursor are beginning to emerge with variable results that, in part, reflect differences in study design. This review looks at the mechanisms by which vitamin D may protect against asthma, including increasing glucocorticoid responsiveness, skewing immune ...
Source: Annals of the New York Academy of Sciences - April 16, 2014 Category: Science Authors: Elizabeth H. Mann, Emma S. Chambers, Paul E. Pfeffer, Catherine M. Hawrylowicz Tags: Original Article Source Type: research

Amygdala mediates respiratory responses to sudden arousing stimuli and to restraint stress in rats.
Abstract Both human and animal studies have demonstrated that respiratory parameters change in response to presentation of alerting stimuli as well as during stress; yet central neuronal pathways that mediate such responses remain unknown. The aim of our study was to investigate the involvement of the amygdala in mediating respiratory responses to stressors of various intensities and duration. Adult male Wistar rats (n=8) received microinjections of GABA-A agonist muscimol or saline into the amygdala bilaterally and were subjected to a respiratory recording using whole-body plethysmography. Presentation of acoustic...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - April 16, 2014 Category: Physiology Authors: Bondarenko E, Hodgson DM, Nalivaiko E Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Four-dimensional treatment planning in layer-stacking boost irradiation for carbon-ion pancreatic therapy.
CONCLUSION: In pancreatic particle beam therapy, delivery of the prescribed dose by layer-stacking boost irradiation provides a greater reduction in excessive dose to normal tissues than delivery by passive scattering irradiation. PMID: 24746568 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 16, 2014 Category: Radiology Authors: Mori S, Shinoto M, Yamada S Tags: Radiother Oncol Source Type: research

Longterm follow-up in European respiratory health studies ¿ patterns and implications
Conclusions: We found comparable patterns of long-term participation and loss to follow-up in RHINE, I-ECRHS and ISAYA. Baseline prevalence estimates for long-term participants were slightly lower than for the total baseline population, while exposure-outcome associations were mainly unchanged by loss to follow-up. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 16, 2014 Category: Respiratory Medicine Authors: Ane JohannessenGiuseppe VerlatoBryndis BenediktsdottirBertil ForsbergKarl FranklinThorarinn GislasonMathias HolmChrister JansonRain JögiEva LindbergFerenc MacsaliErnst OmenaasFrancisco RealEirunn SaureVivi SchlünssenTorben SigsgaardTrude SkorgeCecilie S Source Type: research

Gold nanoparticle-based enhanced ELISA for respiratory syncytial virus
New J. Chem., 2014, Advance ArticleDOI: 10.1039/C4NJ00253A, PaperLei Zhan, Wen Bi Wu, Xiao Xi Yang, Cheng Zhi HuangA highly sensitive colorimetric immunoassay for the detection of RSV by adopting AuNPs as multienzyme carriers was developed.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - New J. Chem. latest articles)
Source: RSC - New J. Chem. latest articles - April 15, 2014 Category: Chemistry Authors: Lei Zhan Source Type: research

The 3-NP Model of Striatal Neurodegeneration.
Abstract The mitochondrial toxin 3-nitropropionic acid (3-NP) is an irreversible inhibitor of respiratory chain complex II. Chronic systemic administration of 3-NP to mice, rats, and non-human primates leads to preferential degeneration of the striatum, and produces motor and cognitive symptoms that are highly reminiscent of Huntington's disease (HD). HD is caused by a dominant inherited expansion of CAG repeats in the Huntington gene. Thus, many aspects of HD cannot be mimicked by 3-NP. However, recent research shows that mitochondrial defects and oxidative stress may play a key role in HD pathogenesis, further su...
Source: Current Protocols in Neuroscience - April 15, 2014 Category: Neuroscience Authors: Brouillet E Tags: Curr Protoc Neurosci Source Type: research

Sleep Apnea and 20-Year Follow-Up for All-Cause Mortality, Stroke, and Cancer Incidence and Mortality in the Busselton Health Study Cohort
Conclusions:Moderate-to-severe sleep apnea is independently associated with a large increased risk of all-cause mortality, incident stroke, and cancer incidence and mortality in this community-based sample.Commentary:A commentary on this article appears in this issue on page 363.Citation:Marshall NS; Wong KK; Cullen SR; Knuiman MW; Grunstein RR. Sleep apnea and 20-year follow-up for all-cause mortality, stroke, and cancer incidence and mortality in the Busselton health study cohort. J Clin Sleep Med 2014;10(4):355-362. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2014 Category: Sleep Medicine Source Type: research

The American Academy of Sleep Medicine Inter-scorer Reliability Program: Respiratory Events
Conclusions:The study demonstrated excellent agreement among a large sample of scorers for epochs with no respiratory events. Agreement for some type of event was good, but disagreements in scoring of apnea vs. hypopnea and type of apnea were common. A limitation of the analysis is that most of the records had normal breathing. A review of controversial events yielded no consistent bias that might be resolved by a change of scoring rules.Citation:Rosenberg RS; Van Hout S. The American Academy of Sleep Medicine inter-scorer reliability program: respiratory events. J Clin Sleep Med 2014;10(4):447-454. (Source: Journal of Cli...
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2014 Category: Sleep Medicine Source Type: research

The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis - a randomised controlled trial
Conclusions: Exercise training in bronchiectasis is associated with short term improvement in exercise capacity, dyspnoea and fatigue and fewer exacerbations over 12 months.Trial registry: ClinicalTrials.gov(NCT00885521). (Source: BioMed Central)
Source: BioMed Central - April 15, 2014 Category: Journals (General) Authors: Annemarie L LeeCatherine J HillNola CecinsSue JenkinsChristine F McDonaldAngela T BurgeLinda RautelaRobert G StirlingPhilip J ThompsonAnne E Holland Source Type: research

Can cholesterol be used to distinguish pleural exudates from transudates? evidence from a bivariate meta-analysis
Conclusions: Both pleural cholesterol level and the P/S cholesterol ratio are helpful for the diagnosis of pleural exudates. Nevertheless, the results of pleural cholesterol assays should be interpreted in parallel with the results of traditional tests and clinical information. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 15, 2014 Category: Respiratory Medicine Authors: Yongchun ShenHong ZhuChun WanLei ChenTao WangTing YangFuqiang Wen Source Type: research

A large kindred of pulmonary fibrosis associated with a novel ABCA3 gene variant
Conclusions: We have detected a large kindred with a novel ABCA3 mutation likely causing interstitial lung fibrosis affecting either young and adult family members. We suggest that ABCA3 gene should be considered in genetic testing in the occurrence of familial pulmonary fibrosis. (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2014 Category: Respiratory Medicine Authors: Ilaria CampoMichele ZorzettoFrancesca MarianiZamir KadijaPatrizia MorbiniRoberto DoreEva KaltenbornSabrina FrixelRalf ZarbockGerhard LiebischJan HegermannChristoph WredeMatthias GrieseMaurizio Luisetti Source Type: research

Fluid on the chest
A 29-year-old man was referred from clinic complaining of worsening dyspnoea, chest pain and weight loss for 1 month. He was HIV positive on antiretroviral medication. On arrival in our emergency department he was markedly dyspnoeic with a respiratory rate of 42 breaths per minute. Pulse rate was 150 and blood pressure was 90/52 mm Hg. He had muffled heart sounds and dilated neck veins. A plain chest radiograph (figure 1) showed a massively dilated, globular heart. Bedside ultrasound confirmed a large pericardial effusion with radiological evidence of cardiac tamponade. Urgent pericardiocentesis was performe...
Source: Emergency Medicine Journal - April 15, 2014 Category: Emergency Medicine Authors: Morrison, H., Gilbert, J., Loughborough, W., Pillay, S. Tags: Drugs: infectious diseases, HIV/AIDS, Drugs: cardiovascular system, Pain (neurology), Hypertension, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Ethics Images in emergency medicine Source Type: research

Short answer question case series: ventilatory considerations in a patient with morbid headache
A middle-aged man with a history of smoking and hypertension complains of acute onset severe headache and neck pain last night following the use of intranasal cocaine. On examination, HR 99 blood pressure 132/90 respiratory rate 22 SpO2 95% room air. He is alert but mildly agitated. His cranial nerve, motor-sensory, and funduscopic exams are normal. The remainder of his physical exam is unremarkable, except for mild meningismus. An emergent CT demonstrates an acute subarachnoid haemorrhage (SAH, figure 1). The patient develops increased work of breathing with a pulse oximetry reading of 92% on ambient air. A stat chest X-r...
Source: Emergency Medicine Journal - April 15, 2014 Category: Emergency Medicine Authors: Horeczko, T., Jang, T. Tags: Cranial nerves, Epilepsy and seizures, Headache (including migraine), Pain (neurology), Hypertension, Radiology, Mechanical ventilation, Mechanical ventilation, Clinical diagnostic tests, Radiology (diagnostics) SAQs Source Type: research

Respiratory viral pathogens among Singapore military servicemen 2009 - 2012: epidemiology and clinical characteristics
Conclusion: There are multiple viral etiologies for FRI and ILI with differing clinical symptoms in the Singapore military. Influenza and coxsackevirus were the most common etiology for FRI, while influenza and adenoviruses displayed the most febrile symptoms. Further studies should explore these differences and possible interventions. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - April 15, 2014 Category: Infectious Diseases Authors: Xin TanXiahong ZhaoVernon LeeJin LohBoon TanWee KohSock NgMark ChenAlex Cook Source Type: research

Asymptomatic re-expansion pulmonary oedema with bilateral infiltrates
Introduction Large unilateral pleural effusion is a very common mode of presentation of lung malignancy to physicians. Treatment of malignant pleural effusion usually involves some form of pleural intervention, typically either insertion of an intercostal drain and talc pleurodesis or alternatively placement of an indwelling pleural catheter depending on the presence of trapped lung, planned oncological therapy, patient comorbidities and estimated life expectancy.1 Occasionally, rapid removal of large amounts of pleural fluid can result in sudden re-expansion pulmonary oedema (RPO). Recognition of this rare complication is...
Source: Postgraduate Medical Journal - April 15, 2014 Category: Journals (General) Authors: Devine, M. D., Sellar, C. E., Medford, A. R. Tags: Hypertension, Lung cancer (oncology), Radiology, Lung cancer (respiratory medicine), Surgical diagnostic tests, Cardiothoracic surgery, General surgery, Radiology (diagnostics), Epidemiology Images in medicine Source Type: research

Epidemiology of respiratory symptoms in children with Down syndrome: a nationwide prospective web-based parent-reported study
This study will provide important data on the epidemiology of respiratory symptoms in children with Down syndrome, which will be useful for further studies on treatment options. Also, this study will gain insight in healthcare usage and work absence due to the child's illnesses. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - April 15, 2014 Category: Pediatrics Authors: Ruud VerstegenRoeland van HoutEsther de Vries Source Type: research

Diverse macrophage populations mediate acute lung inflammation and resolution
Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct pathological stages. Fundamental to ARDS is the acute onset of lung inflammation as a part of the body's immune response to a variety of local and systemic stimuli. In patients surviving the inflammatory and subsequent fibroproliferative stages, transition from injury to resolution and recovery is an active process dependent on a series of highly coordinated events regulated by the immune system. Experimental animal models of acute lung injury (ALI) reproduce key components of the injury and resolution phases of human ARDS and provide a metho...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Aggarwal, N. R., King, L. S., D'Alessio, F. R. Tags: REVIEW Source Type: research

Inhibition of the {alpha}v{beta}6 integrin leads to limited alteration of TGF-{alpha}-induced pulmonary fibrosis
A number of growth factors and signaling pathways regulate matrix deposition and fibroblast proliferation in the lung. The epidermal growth factor receptor (EGFR) family of receptors and the transforming growth factor-β (TGF-β) family are active in diverse biological processes and are central mediators in the initiation and maintenance of fibrosis in many diseases. Transforming growth factor-α (TGF-α) is a ligand for the EGFR, and doxycycline (Dox)-inducible transgenic mice conditionally expressing TGF-α specifically in the lung epithelium develop progressive fibrosis accompanied with cachexia, ...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Madala, S. K., Korfhagen, T. R., Schmidt, S., Davidson, C., Edukulla, R., Ikegami, M., Violette, S. M., Weinreb, P. H., Sheppard, D., Hardie, W. D. Tags: CALL FOR PAPERS Source Type: research

Bleomycin delivery by osmotic minipump: similarity to human scleroderma interstitial lung disease
The interstitial lung diseases (ILD) include a large number of chronic, progressive, irreversible respiratory disorders involving pulmonary fibrosis, the most common of which are idiopathic pulmonary fibrosis and scleroderma lung disease (SSc ILD). Because bleomycin causes lung fibrosis when used in cancer chemotherapy, it is used to model human ILD in rodents. In most studies, bleomycin has been delivered directly into the lung by intratracheal or intraoral administration. Here we have compared the effects in mice of bleomycin delivered directly into the lungs (direct model) or systemically using osmotic minipumps (pump m...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Lee, R., Reese, C., Bonner, M., Tourkina, E., Hajdu, Z., Riemer, E. C., Silver, R. M., Visconti, R. P., Hoffman, S. Tags: CALL FOR PAPERS Source Type: research

Suppression of inflammatory cell trafficking and alveolar simplification by the heme oxygenase-1 product carbon monoxide
Bronchopulmonary dysplasia (BPD), a lung disease of prematurely born infants, is characterized in part by arrested development of pulmonary alveolae. We hypothesized that heme oxygenase (HO-1) and its byproduct carbon monoxide (CO), which are thought to be cytoprotective against redox stress, mitigate lung injury and alveolar simplification in hyperoxia-exposed neonatal mice, a model of BPD. Three-day-old C57BL/6J mice were exposed to air or hyperoxia (FiO2, 75%) in the presence or absence of inhaled CO (250 ppm for 1 h twice daily) for 21 days. Hyperoxic exposure increased mean linear intercept, a measure of alveolar simp...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Anyanwu, A. C., Bentley, J. K., Popova, A. P., Malas, O., Alghanem, H., Goldsmith, A. M., Hershenson, M. B., Pinsky, D. J. Tags: ARTICLES Source Type: research