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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Molecular typing and epidemiology of Clostridium difficile in respiratory care wards of central Taiwan
Conclusion Our results demonstrate a high prevalence of toxigenic C. difficile colonization in hospitals. Infection control personnel should pay attention to the increasing numbers of CDI cases, and molecular typing for C. difficile should be performed when necessary. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - January 23, 2015 Category: Microbiology Source Type: research

X-linked hyper-IgM syndrome with CD40LG mutation: Two case reports and literature review in Taiwanese patients
We report an 18-year-old male who was diagnosed initially with hypogammaglobulinemia in infancy, but developed repeated pneumonia, sepsis, cellulitis, perianal abscess, pericarditis, and bronchiectasis despite regular intravenous immunoglobulin replacement therapy. The patient died at age 18 years due to pneumonia and tension pneumothorax. Mutation analysis revealed CD40L gene mutation within Exon 5 at nucleotide position 476 (cDNA 476G > A). This nonsense mutation predicted a tryptophan codon (TGG) change to a stop codon (TGA) at position 140 (W140X), preventing CD40L protein expression. Sequence analysis in the ...
Source: Journal of Microbiology, Immunology and Infection - January 23, 2015 Category: Microbiology Source Type: research

Development of a Multiple-Locus Variable-Number Tandem-Repeat Typing Scheme for Genetic Fingerprinting of Burkholderia cenocepacia and Application to Nationwide Epidemiological Analysis [Epidemiology]
In conclusion, MLVA represents a promising cost-effective first-line tool in B. cenocepacia surveillance. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Segonds, C., Thouverez, M., Barthe, A., Bossuet-Greif, N., Tisseyre, L., Plesiat, P., Vergnaud, G., Chabanon, G., Pourcel, C. Tags: Epidemiology Source Type: research

Molecular and Epidemiological Review of Toxigenic Diphtheria Infections in England between 2007 and 2013 [Epidemiology]
In this report, we undertook the epidemiological and molecular characterization of all toxigenic corynebacterium strains isolated in England between January 2007 and December 2013. Epidemiological aspects include case demographics, risk factors, clinical presentation, treatment, and outcome. Molecular characterization was performed using multilocus sequence typing (MLST) alongside traditional phenotypic methods. In total, there were 20 cases of toxigenic corynebacteria; 12 (60.0%) were caused by Corynebacterium ulcerans, where animal contact was the predominant risk factor. The remaining eight (40.0%) were caused by Coryne...
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Both, L., Collins, S., de Zoysa, A., White, J., Mandal, S., Efstratiou, A. Tags: Epidemiology Source Type: research

Clinical Performance Evaluation of the Sofia RSV FIA Rapid Antigen Test for Diagnosis of Respiratory Syncytial Virus Infection [Virology]
A recently introduced Sofia respiratory syncytial virus (RSV) fluorescent immunoassay (FIA) was evaluated against the BinaxNOW RSV card and the SD Bioline RSV test using 348 respiratory samples. The Sofia, BinaxNOW, and SD Bioline kits showed sensitivities of 66%, 65%, and 64%, respectively, for detecting RSV-A, and 71%, 63%, and 65% for detecting RSV-B, respectively. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Jang, J. W., Cho, C. H., Nam, M.-H., Yoon, S. Y., Lee, C. K., Lim, C. S., Kim, W. J. Tags: Virology Source Type: research

Canine Distemper Virus Antigen Detection in External Epithelia of Recently Vaccinated, Sick Dogs by Fluorescence Microscopy Is a Valuable Prognostic Indicator [Clinical Veterinary Microbiology]
In this study, vaccinated dogs from Oklahoma City that were showing clinical signs of respiratory disease were evaluated for CDV antigen using a direct fluorescent antibody test (FAT). Clinical outcomes after standard symptomatic therapy for respiratory disease were recorded, and a statistical analysis of the results was performed. We present our study showing that CDV FAT results were predictive of clinical recovery (prognostic indicator, prospects of clinical recovery) among vaccinated dogs showing clinical signs of respiratory disease. Negative CDV FAT results equated to 80% chances of recovery after symptomatic therapy...
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Kapil, S., Neel, T. Tags: Clinical Veterinary Microbiology Source Type: research

Evaluation of the Cobas TaqMan MTB Test for the Detection of Mycobacterium tuberculosis Complex According to Acid-Fast-Bacillus Smear Grades in Respiratory Specimens [Mycobacteriology and Aerobic Actinomycetes]
We evaluated the performance of the Cobas TaqMan MTB test (Roche Diagnostics, Basel, Switzerland), stratified by acid-fast bacilli (AFB) smear grades. The sensitivity of this test in smear-positive specimens was >95% in all grades, while that in trace and negative specimens was 85.3% and 34.4%, respectively. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Huh, H. J., Koh, W.-J., Song, D. J., Ki, C.-S., Lee, N. Y. Tags: Mycobacteriology and Aerobic Actinomycetes Source Type: research

Human Adenovirus Type 7 Infection Associated with Severe and Fatal Acute Lower Respiratory Illness and Nosocomial Transmission [Case Reports]
A 23-year-old male died of severe pneumonia and respiratory failure in a tertiary hospital in Beijing, and 4 out of 55 close contacts developed fever. Molecular analysis confirmed human adenovirus type 7 (HAdV7) as the causative agent. We highlight the importance of early diagnosis and treatment and proper transmission control of HAdV7. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 23, 2015 Category: Microbiology Authors: Cui, X., Wen, L., Wu, Z., Liu, N., Yang, C., Liu, W., Ba, Z., Wang, J., Yi, S., Li, H., Liang, B., Li, P., Jia, L., Hao, R., Wang, L., Hua, Y., Wang, Y., Qiu, S., Song, H. Tags: Case Reports Source Type: research

Study of viral pathogenesis in humanized mice
Publication date: April 2015 Source:Current Opinion in Virology, Volume 11 Author(s): Jenna M Gaska , Alexander Ploss Many of the viral pathogens that cause infectious diseases in humans have a highly restricted species tropism, making the study of their pathogenesis and the development of clinical therapies difficult. The improvement of humanized mouse models over the past 30 years has greatly facilitated researchers’ abilities to study host responses to viral infections in a cost effective and ethical manner. From HIV to hepatotropic viruses to Middle East Respiratory Syndrome coronavirus, humanized mice have led to ...
Source: Current Opinion in Virology - January 23, 2015 Category: Virology Source Type: research

α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects
Publication date: March 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1851, Issue 3 Author(s): Marta Fernández-Galilea , Patricia Pérez-Matute , Pedro L. Prieto-Hontoria , Marianne Houssier , María A. Burrell , Dominique Langin , J. Alfredo Martínez , María J. Moreno-Aliaga α-Lipoic acid (α-Lip) is a natural occurring antioxidant with beneficial anti-obesity properties. The aim of this study was to investigate the putative effects of α-Lip on mitochondrial biogenesis and the acquirement of brown-like characteristics by subcutaneous adipocytes from overweight/obese ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 23, 2015 Category: Lipidology Source Type: research

Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice
Background: Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure. Methods: Twelve-week-old NC/Nga mice were divided into 6 groups (n?=?8 for each group): hydrophilic petrolatum only (control); hydrophilic petrolatum plus ASD (ASD); hydrophilic petrolatum and heat inactivated-ASD (H-ASD); Dermatophagoides farinae extract (Df); Df and ASD (Df?+?ASD), and; Df and H-ASD (Df?+?H-AS...
Source: Allergy, Asthma and Clinical Immunology - January 23, 2015 Category: Allergy & Immunology Authors: Sayaka TakeshitaTakahiro TokunagaYoshiko TanabeTadao ArinamiTakamichi IchinoseEmiko Noguchi Source Type: research

Accuracy of tracheal aspirate gram stain in predicting Staphylococcus aureus infection in ventilator-associated pneumonia
Conclusions: A tracheal aspirate Gram stain can be used to rule out the presence of Staphylococcus aureus in patients with a clinical diagnosis of VAP with a 92.8% Negative Predictive Value. Therefore, 7.2% of patients with Staphylococcus aureus would not be protected by an empiric treatment that limits antimicrobial coverage to Staphylococcus aureus only when Gram positive cocci in clusters are identified. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - January 23, 2015 Category: Anesthesiology Authors: Renato SeligmanBeatriz SeligmanLoriane KonkewiczRodrigo dos Santos Source Type: research

Triggering Interventions for Influenza: The ALERT Algorithm
Conclusions. The ALERT algorithm provides a simple, robust, and accurate metric for determining the onset of elevated influenza activity at the community level. This new algorithm provides valuable information that can impact infection prevention recommendations, public health practice, and healthcare delivery. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 23, 2015 Category: Infectious Diseases Authors: Reich, N. G., Cummings, D. A. T., Lauer, S. A., Zorn, M., Robinson, C., Nyquist, A.-C., Price, C. S., Simberkoff, M., Radonovich, L. J., Perl, T. M. Tags: ARTICLES AND COMMENTARIES Source Type: research

Editorial Commentary: New Strategies for Treatment of Humans With Acute Lung Injury/Acute Respiratory Distress Syndrome
(Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - January 23, 2015 Category: Infectious Diseases Authors: Ward, P. A. Tags: ARTICLES AND COMMENTARIES Source Type: research

Extension of traditional infectious disease surveillance with a repeated population survey
Conclusions: Extending traditional surveillance with a repeated population survey offers the unique opportunity to gather data for a multitude of purposes. The survey already has been used in two outbreak investigations and two case–control studies. It is cost-effective and may provide novel epidemiological insights towards risk group and risk factor identification and characterization for a variety of infectious diseases. The survey will be continued and expanded in use. (Source: The European Journal of Public Health)
Source: The European Journal of Public Health - January 23, 2015 Category: Journals (General) Authors: Friesema, I. H. M., van Gageldonk-Lafeber, A. B., van Pelt, W. Tags: Infectious diseases Source Type: research

Pertussis in the Newborn: certainties and uncertainties in 2014
Bordetella pertussis infection remains a serious potential health risk to infants, specially in those too young to be vaccinated. Over the recent years, numerous sources highlighted a widespread resurgence, making it, again, a challenging disease. Globally, pertussis is ranked among the 10 leading causes of childhood mortality. This review summarizes the most recent literature and will address the most important aspects that pediatricians and neonatologists must be familiar with, when treating a newborńs pertussis infection. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - January 23, 2015 Category: Respiratory Medicine Authors: Gustavo Rocha, Paulo Soares, Henrique Soares, Susana Pissarra, Hercília Guimarães Tags: Review Source Type: research

Pulmonary manifestations of pyoderma gangrenosum: 2 cases and a review of the literature
Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic dermatologic disease that occasionally is accompanied by extracutaneous manifestations, amongst these is pulmonary involvement. The etiology is unknown. More than 50% of PG cases are associated with an underlying systemic disease such as inflammatory bowel disease, rheumatoid arthritis, hematological disorder or malignancy. Extracutaneous manifestations are rare and only 29 cases of pulmonary involvement have been reported previously in the literature. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 23, 2015 Category: Respiratory Medicine Authors: Melina Gade, Frej Studstrup, Anne Kathrine Andersen, Ole Hilberg, Carsten Fogh, Elisabeth Bendstrup Tags: Review Source Type: research

A comprehensive database of Duchenne and Becker muscular dystrophy patients (0¿18 years old) in East China
Conclusions: The database is the first linking accurate genetic diagnosis with clinical manifestation and treatment status of dystrophinopathy patients in East China. It provides comprehensive information essential for further patient management, especially for promotion of international cooperation in developing experimental therapies such as exon skipping and read-through of nonsense mutations targeting a subgroup of DMD patient population. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - January 23, 2015 Category: Internal Medicine Authors: Xihua LiLei ZhaoShuizhen ZhouChaoping HuYiyun ShiWei ShiHui LiFang LiuBingbing WuYi Wang Source Type: research

The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Drosophila Airways
by Ryo Matsuda, Chie Hosono, Kaoru Saigo, Christos Samakovlis The tubular networks of the Drosophila respiratory system and our vasculature show distinct branching patterns and tube shapes in different body regions. These local variations are crucial for organ function and organismal fitness. Organotypic patterns and tube geometries in branched networks are typically controlled by variations of extrinsic signaling but the impact of intrinsic factors on branch patterns and shapes is not well explored. Here, we show that the intersection of extrinsic hedgehog(hh) and WNT/wingless (wg) signaling with the tube-intrinsic Hox c...
Source: PLoS Genetics - January 23, 2015 Category: Genetics & Stem Cells Authors: Ryo Matsuda et al. Source Type: research

Prospective and retrospective evaluation of the Cepheid Xpert Flu/RSV XC assay for rapid detection of influenza A, influenza B, and Respiratory Syncytial virus
A total of 281 clinical specimens (nasal swabs, nasopharyngeal aspirates) were tested with the Xpert® Flu/RSV XC. The results were compared to those obtained with the rt-RT-PCR assays routinely used in our laboratory. The Xpert® Flu/RSV XC showed sensitivity/specificity of 97.8%/100% and 97.9%/100% for Flu and RSV respectively. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - January 23, 2015 Category: Microbiology Authors: Nicolas Salez, Antoine Nougairede, Laetitia Ninove, Christine Zandotti, Xavier de Lamballerie, Remi N. Charrel Source Type: research

Worker illness related to newly marketed pesticides - douglas county, washington, 2014.
Abstract On April 10, 2014 the Washington State Department of Agriculture (WSDA) was notified by a local newspaper of a suspected pesticide poisoning incident in Douglas County involving pesticides not previously reported in the published literature to be associated with human illness. On that same day, WSDA notified the Washington State Department of Health, which investigated this incident by conducting a site visit, reviewing medical and applicator records, and interviewing affected farmworkers, pesticide applicators, and the farmworkers' employer. In addition, on April 11, WSDA collected swab, foliage, and clot...
Source: MMWR Morb Mortal Wkl... - January 23, 2015 Category: Epidemiology Authors: Calvert GM, Rodriguez L, Prado JB Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Clinical associations of host genetic variations in the genes of cytokines in critically ill patients
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 23, 2015 Category: Allergy & Immunology Authors: Olesya B. Belopolskaya, Tamara V. Smelaya, Viktor V. Moroz, Arkady M. Golubev, Lyubov E. Salnikova Tags: Original Article Source Type: research

Diffusion-weighted imaging of the liver: comparison of image quality between monopolar and bipolar acquisition schemes at 3T
Conclusion In comparison with past studies performed at 1.5T, when using a modern 3T system, we observed improved image quality of liver DWI using a monopolar, rather than a bipolar, acquisition scheme, largely attributed to higher eSNR. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 22, 2015 Category: Radiology Source Type: research

Delafloxacin for the treatment of respiratory and skin infections
Expert Opinion on Investigational Drugs, Ahead of Print. (Source: Expert Opinion on Investigational Drugs)
Source: Expert Opinion on Investigational Drugs - January 22, 2015 Category: Drugs & Pharmacology Tags: article Source Type: research

Asthma in US Mexican-Origin Children in Early Childhood: Differences in Risk and Protective Factors by Parental Nativity
Conclusions Mexican-origin children experience a constellation of risk and protective factors, but those with US-born parents have elevated asthma risks compared to those with foreign-born parents. Asthma incidence and severity will likely increase as this population becomes increasingly integrated into US society. (Source: Academic Pediatrics)
Source: Academic Pediatrics - January 22, 2015 Category: Pediatrics Source Type: research

Trajectories of multimorbidity: exploring patterns of multimorbidity in patients with more than ten chronic health problems in life course
Conclusion: There are many challenges facing multimorbidity research, including the implementation of a longitudinal, life-time approach from a family practice perspective. The present study, although exploratory by nature, shows that both general and specific mechanisms characterize the development of multimorbidity trajectories. A very small proportion of patients has a very high number of chronic health problems (MM11+) and keeps adding health problems in their life. However, GP?s need to realise that more than one third of their patients accumulate four or more chronic health problems (MM4-5 and MM6-10) in their lifeti...
Source: BMC Family Practice - January 22, 2015 Category: Primary Care Authors: Rein VosMarjan van den AkkerJos BoestenCaroline RobertsonJob Metsemakers Source Type: research

The relationship between driving simulation performance and obstructive sleep apnoea risk, daytime sleepiness, obesity and road traffic accident history of commercial drivers in Turkey
Conclusions Cognitive-psychomotor functions can be impaired in obese and high risk of OSA patients. In our opinion, requiring obese and/or high risk of OSA drivers to take PTAS tests that assess driving skills and psychomotor-cognitive functions crucial to those skills would significantly improve road traffic safety, which is of considerable importance to public health. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea
Conclusions The conventional AHI was found to be susceptible even to minor changes in ODT level which may lead to substantial variability in AHI-based classification of disease severity. Since the adjusted AHI comprises information on severity of individual breathing cessations, it reduces the variability related to ODT levels used in hypopnea scoring and can increase the accuracy of estimation of OSA severity. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea
Conclusions OSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP treatment. In vitro IHR could induce TLR2/6 co-upregulation. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Effects of Polluted Air on Cardiovascular and Hematological Parameters After Progressive Maximal Aerobic Exercise
Conclusion Acute exposure to high concentrations of pollutants during exercise resulted in decline in cardiovascular functions and hematological parameters in healthy athletes. (Source: Lung)
Source: Lung - January 22, 2015 Category: Respiratory Medicine Source Type: research

Impact of a countywide smoke-free workplace law on emergency department visits for respiratory diseases: a retrospective cohort study
Conclusions: In Olmsted County, MN, asthma-related ED visits declined significantly after enactment of a smoke-free law. These results add to the body of literature supporting community health benefits of smoke-free policies in public environments and their potential to reduce health care costs. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - January 22, 2015 Category: Respiratory Medicine Authors: Ivana CroghanJon EbbertJames HaysDarrell SchroederAlanna ChamberlainVéronique RogerRichard Hurt Source Type: research

Integrating Pulmonary Rehabilitation into the Multidisciplinary Management of Lung Cancer: A Review
Lung cancer is the number one cause of cancer related deaths. It is increasingly recognized that a multidisciplinary approach to the diagnosis and management of patients with lung cancer represents the ideal model for health care delivery. Given the high incidence of comorbid lung disease in lung cancer patients, strategies targeted at improving or optimizing these conditions may improve outcomes. Pulmonary rehabilitation (PR) has proven to be a useful management strategy for patients with chronic lung diseases including chronic obstructive pulmonary disease, interstitial lung disease and pulmonary hypertension. (Source: R...
Source: Respiratory Medicine CME - January 22, 2015 Category: Respiratory Medicine Authors: Hiram Rivas-Perez, Patrick Nana-Sinkam Tags: Review Source Type: research

Costs and health-related quality of life of patients with cystic fibrosis and their carers in France
Our goal was to provide data on the economic burden and health-related quality of life (HRQoL) associated with cystic fibrosis (CF) in France. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - January 22, 2015 Category: Respiratory Medicine Authors: Karine Chevreul, Karen Berg Brigham, Morgane Michel, Gilles Rault, BURQOL-RD Research Network Tags: Original Article Source Type: research

Pollution control up in the air
Publication date: Available online 22 January 2015 Source:The Lancet Respiratory Medicine Author(s): The Lancet Respiratory Medicine (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial
Publication date: Available online 21 January 2015 Source:The Lancet Respiratory Medicine Author(s): Amy H Y Chan , Alistair W Stewart , Jeff Harrison , Carlos A Camargo Jr , Peter N Black , Edwin A Mitchell Background Suboptimum adherence to preventive asthma treatment is associated with substantial morbidity and mortality, yet adherence often remains poor. We aimed to investigate whether use of an inhaler with audiovisual reminders leads to improved adherence and asthma outcomes in school-aged children who presented to the emergency department with an asthma exacerbation. Methods We did a randomised controlled trial i...
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

Monitoring and adherence in asthma management
Publication date: Available online 21 January 2015 Source:The Lancet Respiratory Medicine Author(s): Stanley J Szefler (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

Incidence and severity of childhood pneumonia in the first year of life in a South African birth cohort: the Drakenstein Child Health Study
Publication date: February 2015 Source:The Lancet Global Health, Volume 3, Issue 2 Author(s): David M le Roux , Landon Myer , Mark P Nicol , Heather J Zar Background Childhood pneumonia causes substantial mortality and morbidity. Accurate measurements of pneumonia incidence are scarce in low-income and middle-income countries, particularly after implementation of pneumococcal conjugate vaccine. We aimed to assess the incidence, severity, and risk factors for pneumonia in the first year of life in children enrolled in a South African birth cohort. Methods This birth cohort study is being done at two sites in Paarl, a per...
Source: The Lancet Global Health - January 22, 2015 Category: Global & Universal Source Type: research

Comparative Effectiveness of Three Anxiolytics for Acute Respiratory Infections: Antibiotics, C-Reactive Protein Point-of-Care Testing, and Improved Communication
(Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - January 22, 2015 Category: Internal Medicine Source Type: research

Extracorporeal life support as bridge to lung transplantation: a systematic review
Conclusions: In most of the studies, patients on ECMO while awaiting lung transplantation also received invasive mechanical ventilation. Therefore, whether ECMO as an alternative, rather than an adjunction, to invasive mechanical ventilation is a better bridging strategy to lung transplantation still remains an unresolved issue. ECMO support as a bridge for these patients could provide acceptable one-year survival. Future studies are needed to investigate ECMO as part of an algorithm of care for patients with end-stage lung disease. (Source: Critical Care)
Source: Critical Care - January 22, 2015 Category: Intensive Care Authors: Davide ChiumelloSilvia CoppolaSara FroioAndrea ColomboLorenzo Del Sorbo Source Type: research

Overview of Disinfection By-products and Associated Health Effects
Abstract The presence of chemical compounds formed as disinfection by-products (DBPs) is widespread in developed countries, and virtually whole populations are exposed to these chemicals through ingestion, inhalation, or dermal absorption from drinking water and swimming pools. Epidemiological evidence has shown a consistent association between long-term exposure to trihalomethanes and the risk of bladder cancer, although the causal nature of the association is not conclusive. Evidence concerning other cancer sites is insufficient or mixed. Numerous studies have evaluated reproductive implications, including sperm...
Source: Current Environmental Health Reports - January 22, 2015 Category: Environmental Health Source Type: research

IJERPH, Vol. 12, Pages 1135-1155: Nuclear and Mitochondrial DNA Alterations in Newborns with Prenatal Exposure to Cigarette Smoke
Newborns exposed to maternal cigarette smoke (CS) in utero have an increased risk of developing chronic diseases, cancer, and acquiring decreased cognitive function in adulthood. Although the literature reports many deleterious effects associated with maternal cigarette smoking on the fetus, the molecular alterations and mechanisms of action are not yet clear. Smoking may act directly on nuclear DNA by inducing mutations or epigenetic modifications. Recent studies also indicate that smoking may act on mitochondrial DNA by inducing a change in the number of copies to make up for the damage caused by smoking on the respirato...
Source: International Journal of Environmental Research and Public Health - January 22, 2015 Category: Environmental Health Authors: Francesca PiriniElisa GuidaFahcina LawsonAndrea MancinelliRafael Guerrero-Preston Tags: Review Source Type: research

Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia
In conclusion, steatotic livers exhibited apparent mitochondrial dysfunction through an alteration in C‐I activity, and this made them more susceptible to prolonged cold ischemia. The clinically based IPC protocol used here restored MF in cases of mild hepatic steatosis by attenuating C‐I–mediated leaks after prolonged cold ischemia, but it did work not in livers with moderate or severe steatosis. Liver Transpl, 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - January 22, 2015 Category: Transplant Surgery Authors: Michael J. J. Chu, Anthony J. R. Hickey, Yannan Jiang, Amorita Petzer, Adam S. J. R. Bartlett, Anthony R. J. Phillips Tags: Original Article Source Type: research

Update on Fungal Respiratory Disease in Horses
This article summarizes the available literature regarding the cause, diagnosis, and treatment of equine fungal respiratory disease. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - January 22, 2015 Category: Veterinary Research Authors: Allison J. Stewart, Rosemary S. Cuming Source Type: research