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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Murine lung injury caused by
Conclusions: GLP and ouabain induced lung injury, as evidenced by increased lung inflammation and hemorrhage. To our knowledge, this is the first report showing GLP induces lung injury. GLP and ouabain are Na/K-ATPase targets, triggering intracellular signaling pathways. We showed p38 activation by GLP-induced lung injury, which was may be linked to Na/K-ATPase inhibition. Lung inflammation induced by GLP was not dependent on TLR4 activation. (Source: Respiratory Research)
Source: Respiratory Research - August 14, 2014 Category: Respiratory Medicine Authors: Cassiano Gonçalves-de-AlbuquerquePatrícia BurthAdriana SilvaIsabel de MoraesFlora OliveiraRicardo SantelliAline FreireGerson de LimaEmilson da SilvaCamila da SilvaVerônica MorandiPatrícia BozzaMauricio Younes-IbrahimHugo de Castro Faria NetoMauro de C Source Type: research

Aerobic exercise improves gastrointestinal motility in psychiatric inpatients.
CONCLUSION: A 12-wk aerobic exercise program can benefit psychiatric inpatients by increasing intestinal motility, possibly decreasing risk of metabolic- and cardiovascular-related disease. PMID: 25132778 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Kim YS, Song BK, Oh JS, Woo SS Tags: World J Gastroenterol Source Type: research

Transport and deposition of pharmaceutical particles in three commercial spacer–MDI combinations
Respiratory drug delivery has been under the research spotlight for the past few decades, mainly due to the high incidence of pulmonary diseases and the fact that this type of delivery offers the highest efficiency for treatment. Despite its invaluable benefits, there are some major drawbacks to respiratory drug delivery, the most important of which being poor delivery efficiency and relatively high drug deposition in undesirable regions, such as the mouth cavity. One way to improve the efficiency of respiratory drug delivery with metered-dose inhalers is placing a respiratory spacer between the inhaler exit and the mouth....
Source: Computers in Biology and Medicine - August 14, 2014 Category: Bioinformatics Authors: A. Yazdani, M. Normandie, M. Yousefi, M.S. Saidi, G. Ahmadi Source Type: research

Arterialised earlobe capillary blood gases in the COPD population.
Abstract Arterialised ear lobe capillary blood (ELCB) gas sampling is a widely used clinical procedure undertaken across both primary and secondary care settings. The prevalence of this sampling method has grown among health professionals, coupled with a growing demand for domiciliary oxygen therapy in the UK, in particular for those who have chronic obstructive pulmonary disease (COPD). Research studies supporting arterialised ELCB gas sampling show inconsistencies in technique, and a survey of respiratory nurses' current practice demonstrated wider inconsistencies. In the absence of national clinical guidelines t...
Source: British Journal of Nursing - August 14, 2014 Category: Nursing Authors: Young J Tags: Br J Nurs Source Type: research

Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction
Primary graft dysfunction (PGD), as characterized by pulmonary infiltrates and high oxygen requirements shortly after reperfusion, is the major cause of early morbidity and mortality after lung transplantation. Donor, recipient and allograft-handling factors are thought to contribute, although new insights regarding pathogenesis are needed to guide approaches to prevention and therapy. Mast cells have been implicated in ischemic tissue injury in other model systems and in allograft rejection, leading to the hypothesis that mast cell degranulation contributes to lung injury following reperfusion injury.We tested this hypoth...
Source: Respiratory Research - August 13, 2014 Category: Respiratory Medicine Authors: John GreenlandXiang XuDavid SayahFeng LiuKirk JonesMark LooneyGeorge Caughey Source Type: research

Hourly differences in air pollution and risk of respiratory disease in the elderly: a time-stratified case-crossover study
Background: Epidemiological studies have shown adverse effects of short-term exposure to air pollution on respiratory disease outcomes; however, few studies examined this association on an hourly time scale. We evaluated the associations between hourly changes in air pollution and the risk of respiratory disease in the elderly, using the time of the emergency call as the disease onset for each case. Methods: We used a time-stratified case-crossover design. Study participants were 6,925 residents of the city of Okayama, Japan, aged 65 or above who were taken to hospital emergency rooms between January 2006 and December 2010...
Source: Environmental Health - August 13, 2014 Category: Environmental Health Authors: Takashi YorifujiEtsuji SuzukiSaori Kashima Source Type: research

Airway pH monitoring in patients with suspected obstructive sleep apnea using the Dx‐pH oropharyngeal probe: preliminary report of a prospective cohort study
ConclusionBy using the new sensitive Dx‐pH oropharyngeal probe with PSG, we found that OSA does not correlate with a higher incidence of LPR episodes.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - August 13, 2014 Category: ENT & OMF Authors: Chen‐Chi Wang, Han‐Chung Lien, Armando De Virgilio, Wei‐Chang Huang, Ming‐Feng Wu, Shih‐An Liu, Ching‐Ping Wang, Shang‐Heng Wu, Kai‐Li Liang, Rong‐San Jiang Tags: Original Article Source Type: research

Duelling letters: which one would you sign?
Big Tobacco has got to be pretty pleased at the media storm over duelling letters sent by public health scientists and practitioners to the Director-General of the WHO concerning tobacco harm reduction and e-cigarettes. The first of these letters, with 53 signatories, argued in favour of including harm reduction strategies in WHO's approach to tobacco control and proposed a set of 10 guiding principles for formulating policy around nicotine products.1 In response, a second letter was sent with 129 signatories, which emphasised the involvement of tobacco companies in the e-cigarette market and argued against exempting e-cig...
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Gartner, C., Malone, R. E. Tags: Editorial Source Type: research

Worldwide news and comment
Singapore/world: trade fairs shunned Singapore is the latest country to see a major tobacco trade fair cancelled. The official reason given by organisers was lack of government commitment, however it is likely the threat of civil society action played a part, given a rising tide of protests. World Tobacco Asia 2014 had originally been planned for April in Jakarta, Indonesia, but was relocated to Singapore and rescheduled to November after the Inter-tabac Asia Trade Fair planned for February in Bali was cancelled abruptly under orders of the provincial governor following international protests. Daily Singapore broadsheet th...
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Tags: TC News analysis Source Type: research

Electronic nicotine delivery system (electronic cigarette) awareness, use, reactions and beliefs: a systematic review
Conclusions ENDS use is expanding rapidly despite experts’ concerns about safety, dual use and possible ‘gateway’ effects. More research is needed on effective public health messages, perceived health risks, validity of self-reports of smoking cessation and the use of different kinds of ENDS. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Pepper, J. K., Brewer, N. T. Tags: Review Source Type: research

The Lighter Side
(Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Tags: PostScript Source Type: research

Public education about the relative harm of tobacco products: an intervention for tobacco control professionals
Conclusions Public education campaigns are urgently needed for tobacco control professionals and consumers to increase awareness and understanding of the continuum of risk among tobacco products. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Biener, L., Nyman, A. L., Stepanov, I., Hatsukami, D. Tags: Research paper Source Type: research

'Zhonghua' tobacco advertisement in Shanghai: a descriptive study
Conclusions Zhonghua cigarettes are promoted directly and indirectly through a variety of channels. This study suggests there is an urgent need to establish comprehensive bans that prohibit all types of tobacco advertisements in China. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Zheng, P., Ge, X., Qian, H., Wang, F., Fu, H., Berg, C. J., Kegler, M. C. Tags: Research paper Source Type: research

It is better to be a fat ex-smoker than a thin smoker: findings from the 1997-2004 National Health Interview Survey-National Death Index linkage study
Conclusions This article concludes that, overall, mortality risk is smaller in overweight or obese ex-smokers than normal-weight smokers. Smoking cessation interventions can tailor messages that highlight the greater reduction in mortality associated with quitting, compared with potential weight gain. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Siahpush, M., Singh, G. K., Tibbits, M., Pinard, C. A., Shaikh, R. A., Yaroch, A. Tags: Research paper Source Type: research

Protection from secondhand smoke in countries belonging to the WHO European Region: an assessment of legislation
Conclusions Nine years after the adoption of the WHO FCTC there are still legal formulas in which smoking is allowed in several facilities, through the inclusion of separated areas, ventilated areas and other conditions. Tobacco control efforts still face the challenge of eradicating the legal clauses that prevent 100% smokefree environments. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Martinez, C., Martinez-Sanchez, J. M., Robinson, G., Bethke, C., Fernandez, E. Tags: Research paper Source Type: research

Assessing the effectiveness of antismoking television advertisements: do audience ratings of perceived effectiveness predict changes in quitting intentions and smoking behaviours?
Conclusions Audience ratings of PPE, but not ADPE, were found to predict subsequent intention and behaviour change. These findings increase confidence in the use of PE measures to pretest and evaluate antismoking television advertisements, particularly when these measures tap the extent to which a smoker has been personally affected by the message. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Brennan, E., Durkin, S. J., Wakefield, M. A., Kashima, Y. Tags: Research paper Source Type: research

Cross-country comparison of waterpipe use: nationally representative data from 13 low and middle-income countries from the Global Adult Tobacco Survey (GATS)
Conclusions GATS data provide the ability to analyse waterpipe use within a country and across countries. Monitoring of waterpipe use at a national level will better enable countries to target tobacco control interventions such as education campaigns about the negative health effects of waterpipe use. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Morton, J., Song, Y., Fouad, H., Awa, F. E., Abou El Naga, R., Zhao, L., Palipudi, K., Asma, S., on behalf of the GATS Collaborative Group Tags: Open access Research paper Source Type: research

Estimating the cost of a smoking employee
Conclusions Employees who smoke impose significant excess costs on private employers. The results of this study may help inform employer decisions about tobacco-related policies. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Berman, M., Crane, R., Seiber, E., Munur, M. Tags: Press releases Research paper Source Type: research

The economic costs of tobacco consumption in the Kingdom of Saudi Arabia
Conclusions In Saudi Arabia, short-term and long-term economic gains will result from reductions in tobacco use. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: AlBedah, A. M. N., Khalil, M. K. M. Tags: Research paper Source Type: research

The cost-effectiveness of call-back counselling for smoking cessation
Conclusions Call-back counselling is a cost-effective intervention for smoking cessation that can be provided by a centralised service for a large population, and to reach people in isolated communities. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Lal, A., Mihalopoulos, C., Wallace, A., Vos, T. Tags: Research paper Source Type: research

Impact of the Irish smoking ban on sales in bars using a large business-level data set from 1999 to 2007
Conclusions The results indicate that although some bars saw positive effects and some negative, the overall impact of the smoking ban on the value of sales in bars was negligible. These findings provide further supporting evidence that comprehensive smoke-free workplace legislation does not harm hospitality businesses while having positive health effects. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Cornelsen, L., Normand, C. Tags: Research paper Source Type: research

Availability of snus and its sale to minors in a large Minnesota city
Conclusions Prevalence of snus sales to minors appeared to be higher than that of cigarette sales to minors according to the 2011 Synar report. Futures studies are needed to determine whether tobacco retailers are more likely to sell snus than cigarettes to minors. Interventions such as public and retailer policies are needed to reduce the likelihood of tobacco retailers selling snus to minors. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Choi, K., Fabian, L. E. A., Brock, B., Engman, K. H., Jansen, J., Forster, J. L. Tags: Brief report Source Type: research

The recent and projected public health and economic benefits of cigarette taxation in Greece
Conclusions Nations such as Greece, should employ taxation as a crucial measure to promote public health and economic development in such dire times. International economic organisations should aggressively pursue programmes and policies that champion the economic benefits of tobacco taxation. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Alpert, H. R., Vardavas, C. I., Chaloupka, F. J., Vozikis, A., Athanasakis, K., Kyriopoulos, I., Bertic, M., Behrakis, P. K., Connolly, G. N. Tags: Brief report Source Type: research

'Action. Adventure. Special Offers.': how Marlboro engages consumers on its website
The Marlboro website epitomises the industry's creative use of online platforms to engage consumers consistently over extended time periods. Most recently, the tagline for the Marlboro brand's website promises ‘Action. Adventure. Special Offers. Find it all at MARLBORO.COM.’1 As the tobacco industry faces expanded restrictions for marketing their products through more traditional media channels,2–4 companies have turned to the internet—which remains a space that is both less regulated and more difficult to regulate5—to engage consumers. As researchers have observed, viewers are likely to &lsqu...
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Ilakkuvan, V., Cantrell, J., Vallone, D. Tags: Ad watch Source Type: research

The Lighter Side
(Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Tags: PostScript Source Type: research

Tracking the relevance of the WHO Framework Convention on Tobacco Control in legislation and litigation through the online resource, Tobacco Control Laws
The WHO Framework Convention on Tobacco Control is increasingly referenced and incorporated into the objectives, definitions and provisions of domestic legislation worldwide. It is also relied upon by courts in interpreting and upholding strong tobacco control measures challenged by the tobacco industry. In this special communication, we describe these trends and explore the important new online resource—Tobacco Control Laws (http://www.tobaccocontrollaws.org)—that has been used to track them. (Source: Tobacco Control)
Source: Tobacco Control - August 13, 2014 Category: Respiratory Medicine Authors: Muggli, M. E., Zheng, A., Liberman, J., Coxon, N., Candler, L., Donley, K., Lambert, P. Tags: Special communication Source Type: research

Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure
Conclusions: These findings suggest that stimulating the NO pathway by sildenafil and VIP exert their beneficial effect against hyperoxia-induced BHR via preserving normal EELV, inhibiting airway inflammation and preserving the physiological lung structure, whereas the antiapoptotic potential of these treatments were not apparent in this process. (Source: Respiratory Research)
Source: Respiratory Research - August 13, 2014 Category: Respiratory Medicine Authors: Dorottya CzövekFerenc PetákYves DonatiXavier BelinJean-Claude PacheConstance Barazzone ArgiroffoWalid Habre Source Type: research

Effects of interval and continuous exercise training on autonomic cardiac function in COPD patients
ConclusionsBoth IT and CT exercise training improve heart rate recovery and CR in COPD patients. These benefits could help to individualize exercise training. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 13, 2014 Category: Respiratory Medicine Authors: Diego A. Rodríguez, Ane Arbillaga, Anael Barberan‐Garcia, Alba Ramirez‐Sarmiento, Yolanda Torralba, Jordi Vilaró, Elena Gimeno‐Santos, Joaquim Gea, Mauricio Orozco‐Levi, Josep Roca, Ester Marco Tags: Original Article Source Type: research

Epidemiological characteristics and immune status of children with Respiratory Syncytial Virus
Respiratory Syncytial Virus (RSV) infections are the dominant cause of pneumonia in children. In order to determine the epidemiological characteristics and immune status of children with Respiratory Syncytial Virus, a prospective study was performed among patients with RSV infection. Comparisons between RSV pneumonia group and normal control group, RSV pneumonia group had lower IL‐2 (median levels, pg/ml: 3.8 vs. 5.1, P < 0.01), and higher IL‐4 (median levels, pg/ml: 3.2 vs. 2.4, P < 0.01), IL‐10 (median levels, pg/ml: 12.2 vs. 2.3, P < 0.01), and IFN‐γ (median levels, pg/ml: 13.4 vs. 4.6, P...
Source: Journal of Medical Virology - August 13, 2014 Category: Virology Authors: Qing Ye, Wen‐Xia Shao, Shi‐Qiang Shang, Yan‐Xiang Pan, Hong‐Qiang Shen, Xue‐Jun Chen Tags: Research Article Source Type: research

Long term follow‐up of four patients with Keutel syndrome
This report describes the findings of four sisters with KS born to consanguineous parents were followed for 26 years in an irregular fashion. During follow‐up of the patients over the years the complications appear to be mostly involving the respiratory system. Permanent skin rashes, papillary microcarcinoma of the thyroid, asthma, massive bullous pulmonary emphysema, severe systemic arterial hypertension, and short term memory loss were observed during long term follow‐up. The fertility status of the patients were also observed and infertility was observed in one of three married patients. © 2014 Wiley Periodicals, I...
Source: American Journal of Medical Genetics Part A - August 13, 2014 Category: Genetics & Stem Cells Authors: H.E. Khosroshahi, S.C. Sahin, Y. Akyuz, H. Ede Tags: Clinical Report Source Type: research

HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth.
Abstract Rationale: Protein kinase C zeta (PKCζ) has been reported to act as a tumor suppressor. Deletion of PKCζ in experimental cancer models has been shown to increase tumor growth. However, the mechanisms of PKCζ downregulation have in cancerous cells have not been previously described. Objective: To determine the molecular mechanisms that lead to decreased PKCζ expression and thus increased survival in cancer cells and tumors. Measurements and Main Results: Hypoxia is a hallmark of growing solid tumors. We found that during hypoxia, PKCζ is ubiquitinated and degraded via the ubiquitin ligase HOIL-1L, a co...
Source: American Journal of Respiratory and Critical Care Medicine - August 13, 2014 Category: Respiratory Medicine Authors: Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI Tags: Am J Respir Crit Care Med Source Type: research

Complete sequence analysis of mitochondrial DNA and telomere length in aplastic anemia.
Abstract The present study was primarily undertaken to examine the hypothesis that mitochondrial DNA (mtDNA) mutations and telomere length may be associated with aplastic anemia (AA). Our study included a single institution analysis of 40 patients presenting with AA first diagnosed at the Affiliated Hospital of Shandong, University of Traditional Chinese Medicine between 2010 and 2013. Bone marrow and oral epithelial samples were collected from patients with AA (n=40) for mtDNA mutation and telomere length determinations. Bone marrow specimens were collected from 40 healthy volunteers as controls for the examina...
Source: International Journal of Molecular Medicine - August 13, 2014 Category: Molecular Biology Authors: Cui X, Wang J, Cai Z, Wang J, Liu K, Cui S, Zhang J, Luo Y, Wang X, Li W, Jing J Tags: Int J Mol Med Source Type: research

MAG-EPA and 17,18-EpETE target cytoplasmic signalling pathways to reduce short-term airway hyperresponsiveness.
This study was aimed to investigate the role of eicosapentaenoic acid monoacylglyceride (MAG-EPA) and 17,18-epoxyeicosatetraenoic acid (17,18-EpETE) on the regulation of contractile reactivity and nuclear protein expression in 72-h-cultured and TNF-α-treated guinea pig tracheal rings. Tension measurements performed on native tissues demonstrated that the cytochrome P-450 epoxygenase (CYP450)-dependent EPA metabolite, 17,18-EpETE, displayed a higher potency than MAG-EPA in inhibiting U-46619-induced tone. Calphostin C (a PKC inhibitor), whether in association or not with MAG-EPA or 17,18-EpETE, had no further effect, while...
Source: Pflugers Archiv : European Journal of Physiology - August 13, 2014 Category: Physiology Authors: Khaddaj-Mallat R, Rousseau E Tags: Pflugers Arch Source Type: research

Accuracy of a novel auto-CPAP device to evaluate the residual apnea-hypopnea index in patients with obstructive sleep apnea.
CONCLUSIONS: The automatic analysis from auto-CPAP (S9 Autoset) showed a good diagnostic accuracy to identify residual sleep apnea. The absolute agreement between PSG and auto-CPAP to classify the respiratory events correctly varied from very low (obstructive apneas, hypopneas) to moderate (central apneas). PMID: 25115886 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - August 13, 2014 Category: Sleep Medicine Authors: Nigro CA, González S, Arce A, Aragone MR, Nigro L Tags: Sleep Breath Source Type: research

Xenograft Model for Therapeutic Drug Testing in Recurrent Respiratory Papillomatosis.
CONCLUSION: We report here the first successful case of serial xenografting of a tracheal papilloma in vivo with a therapeutic response observed with drug testing. In severely immunocompromised mice, the HPV genome and squamous differentiation of the papilloma can be maintained for multiple generations. This is a feasible approach to identify therapeutic agents in the treatment of recurrent respiratory papillomatosis. PMID: 25124839 [PubMed - as supplied by publisher] (Source: The Annals of Otology, Rhinology, and Laryngology)
Source: The Annals of Otology, Rhinology, and Laryngology - August 13, 2014 Category: ENT & OMF Authors: Ahn J, Bishop JA, Akpeng B, Pai SI, Best SR Tags: Ann Otol Rhinol Laryngol Source Type: research

RDOS-Family: A Guided Learning Tool for Layperson Assessment of Respiratory Distress
Journal of Palliative Medicine , Vol. 0, No. 0. (Source: Journal of Palliative Medicine)
Source: Journal of Palliative Medicine - August 12, 2014 Category: Palliative Care Tags: article Source Type: research

Respiratory pattern of diaphragmatic breathing and pilates breathing in COPD subjects
CONCLUSIONS: DB showed positive effects such as increase in lung volumes, respiratory motion, and SpO2 and reduction in respiratory rate. Although there were no changes in volume and time measurements during PB in COPD, this breathing pattern increased volumes in the healthy subjects and increased oxygenation in both groups. In this context, the acute benefits of DB are emphasized as a supporting treatment in respiratory rehabilitation programs. (Source: Revista Brasileira de Fisioterapia)
Source: Revista Brasileira de Fisioterapia - August 12, 2014 Category: Physiotherapy Source Type: research

Effect of a low-starch/low-dairy diet on fat oxidation in overweight and obese women with polycystic ovary syndrome
In conclusion, an 8-week low-starch/low-dairy diet increased fat oxidation in overweight and obese women with PCOS. (Source: Applied Physiology, Nutrition, and Metabolism)
Source: Applied Physiology, Nutrition, and Metabolism - August 12, 2014 Category: Physiology Tags: article Source Type: research

Emergent severe acute respiratory distress syndrome caused by adenovirus type 55 in immunocompetent adults in 2013: a prospective observational study
Conclusions: HAdV-55 may cause severe ARDS in immunocompetent young men. Persistent high fever, dyspnea, and rapid progression to respiratory failure within 2?weeks, together with bilateral consolidations and infiltrates, are the most frequent clinical manifestations of HAdV-55-induced severe ARDS. Viral load monitoring may help predict patients? severity and outcome. NPPV and IMV failure rate were very high, and ECMO may be the choice of respiratory support.Trial registrationClinicaltrials.gov NCT01585922. Registered 20 April 2012. (Source: Critical Care)
Source: Critical Care - August 12, 2014 Category: Intensive Care Authors: Bing SunHangyong HeZheng WangJiuxin QuXuyan LiChengjun BanJun WanBin CaoZhaohui TongChen Wang Source Type: research

Endurance-training in healthy men is associated with lesser exertional breathlessness that correlates with circulatory-muscular conditioning markers in a cross-sectional design
In conclusion, our data support a weak relationship between exertional breathlessness and circulatory-muscular conditioning, the later being primarily related to vigorous physical activity. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - August 12, 2014 Category: Epidemiology Authors: Laurent PlantierGhanima Al DandachiCécile LondnerAurore Caumont-PrimBrigitte Chevalier-BidaudJean-François ToussaintFrançois-Denis DesgorcesChristophe Delclaux Source Type: research

Guillain‐Barré syndrome patient weaned off ventilation after 22 months
Respiratory failure is a common complication of Guillain‐Barré syndrome (GBS). Patients who need mechanical ventilation usually recover within a few weeks. Here, Dr Gaber reports a case of GBS which required mechanical ventilation for 22 months; the management of this challenging group of patients is rarely reported. (Source: Progress in Neurology and Psychiatry)
Source: Progress in Neurology and Psychiatry - August 12, 2014 Category: Neurology Authors: Tarek A‐Z K Gaber Tags: Case notes Source Type: research

Retrospective Observational study of diagnostic accuracy of the Xpert(R) MTB/RIF assay on fiberoptic bronchoscopy sampling for early diagnosis of smear-negative or sputum-scarce patients with suspected tuberculosis
Conclusion: Our study has confirmed the clinical benefits provided by XP assay compared to SM for the early diagnosis of suspected pulmonary TB cases requiring FOB, on per procedure samples, especially in a low TB-burden country. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 12, 2014 Category: Respiratory Medicine Authors: Pierre Le PaludVincent CattoirBrigitte MalbrunyRomain MagnierKarine CampbellYoussef OulkhouirGérard ZalcmanEmmanuel Bergot Source Type: research

Effects of sigh during pressure control and pressure support ventilation in pulmonary and extrapulmonary mild acute lung injury
Conclusions: In these models of mild ALIp and ALIexp, sigh reduced alveolar collapse and transpulmonary pressures during both PCV and PSV; however, improved lung protection only during PSV in ALIp. (Source: Critical Care)
Source: Critical Care - August 12, 2014 Category: Intensive Care Authors: Lillian MoraesCíntia SantosRaquel SantosFernanda CruzFelipe SaddyMarcelo MoralesVera CapelozziPedro SilvaMarcelo de AbreuCristiane GarciaPaolo PelosiPatricia Rocco Source Type: research

Big fat babies
Babies of 4 kg or more at birth—‘big fat babies’—tend to get a bad press. There are several reasons for this. That they are more likely to have a difficult time squeezing themselves down the birth canal is well known and unsurprising, hence their increased rates of shoulder dystocia and clavicle fracture. But they also get caught in the wake of infants of diabetic mothers, which are also big fat babies, and which historically have had a variety of problems attributed to them: polycythaemia, hypocalcaemia, hypoglycaemia, and a propensity for respiratory distress, among others. Babies who either ...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 12, 2014 Category: Perinatology & Neonatology Authors: Ward Platt, M. P. Tags: Obesity (nutrition), Pregnancy, Child health, Trauma, Diabetes, Metabolic disorders, Health education, Injury, Obesity (public health), Health promotion Editorials Source Type: research