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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Iatrogenic acute cardiac tamponade during percutaneous removal of a fractured peripherally inserted central catheter in a premature neonate
We present a case of ACT in a 4-day-old male infant. On the second admission day, a PICC was inserted. After 2.5 months, chest radiography showed PICC fracture, and its distal portion had migrated into the right pulmonary artery. Percutaneous removal through cardiac catheterization was attempted. However, right ventriculography demonstrated intrapericardial spillage of contrast agents, and iatrogenic ACT was confirmed. Cardiopulmonary resuscitation (CPR) was immediately started with open-chest cardiac massage. Further surgical exploration revealed right atrial appendage perforation. After 25-min CPR, the patient restored s...
Source: Heart and Lung: The Journal of Acute and Critical Care - August 31, 2015 Category: Respiratory Medicine Source Type: research

Iatrogenic pneumothorax: What can we do?
Publication date: Available online 20 June 2015 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Karina R. Peron, Mônica Taminato, Maria Lucia B.M. dos Santos, Artur F. Delgado, Werther B. de Carvalho (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 31, 2015 Category: Respiratory Medicine Source Type: research

Reply to “Effect of cardiac rehabilitation on ventricular repolarization in patients with type 2 diabetes and coronary heart disease: Non-invasive quantification via transmural dispersion of repolarization”
Publication date: Available online 16 June 2015 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Marouane Boukhris, Zied Ibn Elhadj, Abdul Wahab Terra, Salvatore D. Tomasello, Alfredo R. Galassi, Basma Boukhris (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 31, 2015 Category: Respiratory Medicine Source Type: research

A closer look: Alternative pain management practices by heart failure patients with chronic pain
Conclusions Patients with HF and chronic pain use few alternative pain treatments. Screening for chronic pain and referral to Integrative Medicine and/or Palliative care for a pain management consult might reduce the added burden of pain in people with HF. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - August 31, 2015 Category: Respiratory Medicine Source Type: research

Diagnostic significance of cerebrospinal fluid EGFR mutation analysis for leptomeningeal metastasis in non-small-cell lung cancer patients harboring an active EGFR mutation following gefitinib therapy failure
Conclusions Analysis of EGFR mutations in CSF using a highly sensitive real-time PCR assay is a potentially powerful diagnostic method for LM. (Source: Respiratory Investigation)
Source: Respiratory Investigation - August 31, 2015 Category: Respiratory Medicine Source Type: research

Effects of dietary nucleotides on growth, non-specific immune response and disease resistance of sea cucumber Apostichopus japonicas
In conclusion, it was showed that dietary NT does increase the growth performance, non-specific immunity and disease resistance of sea cucumber. The optimum dietary NT supplementation level for sea cucumber was found to be 375 mg/kg. The application of dietary NT may present a novel strategy for health management in sea cucumber's aquaculture. (Source: Fish and Shellfish Immunology)
Source: Fish and Shellfish Immunology - August 31, 2015 Category: Biology Source Type: research

Title: Absence of back to school peaks in human rhinovirus detections and respiratory symptoms in a cohort of children with asthma
This study suggests that hRV infections are common throughout the year among children, and differences in virus prevalence alone may not account for peaks in asthma symptoms. This article is protected by copyright. All rights reserved (Source: Journal of Medical Virology)
Source: Journal of Medical Virology - August 31, 2015 Category: Virology Authors: Sacha Stelzer‐Braid, Euan R. Tovey, Christiana M. Willenborg, Brett G. Toelle, Rose Ampon, Frances L. Garden, Brian G. Oliver, Roxanne Strachan, Yvonne Belessis, Adam Jaffe, Helen K. Reddel, Daniel Crisafulli, Guy B. Marks, William D. Rawlinson Tags: Research Article Source Type: research

Acute respiratory infection case definitions for young children: a systematic review of community‐based epidemiologic studies in South Asia
ConclusionThere is wide variability in case definition label and content combinations to define acute upper and lower respiratory infections in children in community‐based studies in South Asia over the past two decades. These inconsistencies have important implications for the synthesis and translation of knowledge regarding the prevention and treatment of childhood acute respiratory infection.This article is protected by copyright. All rights reserved. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - August 31, 2015 Category: Tropical Medicine Authors: Daniel E. Roth, Michelle F. Gaffey, Evelyn Smith‐Romero, Tiffany Fitzpatrick, Shaun K. Morris Tags: Original Article Source Type: research

The postoperative complication for adenocarcinoma of esophagogastric junction
Conclusion: The positive operative complications for patients with adenocarcinoma of esophagogastric junction were relative high. Moreover, basic heart and lung diseases can increase the risk of developing positive operative complications. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - August 31, 2015 Category: Cancer & Oncology Authors: Hui ZhangXianglin Meng Source Type: research

Patient-controlled intravenous analgesia for non-small cell lung cancer patient after thoracotomy
Conclusion: Intravenous PCIA-controlled intravenous analgesia can significantly decrease the VAS score without increasing the toxicity in NSLCP after thoracotomy. (Source: Journal of Cancer Research and Therapeutics)
Source: Journal of Cancer Research and Therapeutics - August 31, 2015 Category: Cancer & Oncology Authors: Yi ZhouJin-Xi HuangXi-Hua LuYun-Fei ZhangWei Zhang Source Type: research

ERJ September Podcast: Updating the GINA guidelines for asthma control
As part of the September issue, the European Respiratory Journal presents the latest in its series of podcasts, in which chief editor Marc Humbert discusses the new GINA guidelines for asthma control with Prof. Helen K. Reddel from the Woolcock Institute of Medical Research, University of Sydney, Australia. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Tags: Electronic Resources Source Type: research

GINA 2015: the latest iteration of a magnificent journey
The Global Initiative for Asthma (GINA) represents a remarkable source document that has changed the course of asthma in most countries. The first asthma guidelines have been published in Australasia, UK [1] and the USA [2]. Canadian and French recommendations proposed the concept of control [3, 4], and the National Asthma Education and Prevention Program Expert Panel Report initiated the concept of risk for asthma [5]. However, GINA is globally considered to be the prominent asthma recommendation building on existing knowledge and providing several updates or revisions since it was introduced in 1995 [2, 6, 7]. GINA 2015 ...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Bousquet, J., Humbert, M. Tags: Asthma and allergy Editorials Source Type: research

Exercise-induced pulmonary hypertension: at last!
Stress tests are for the identification of silent pathology. Applications to medical diagnosis are numerous. For example, ventilation (V'E) and mean pulmonary artery pressure (mPAP) may overlap at rest, but markedly diverge during exercise in patients with pulmonary hypertension or heart failure and in healthy controls (figure 1). Accordingly, measurements of mPAP during exercise have been part of the diagnostic work-up of pulmonary hypertension since the early years of cardiac catheterisation, more than half a century ago [1]. Yet "exercise-induced pulmonary hypertension", defined by higher than normal mPAP during exercis...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Naeije, R., Vonk Noordegraaf, A., Kovacs, G. Tags: Pulmonary vascular disease Editorials Source Type: research

The different faces of the asthma-COPD overlap syndrome
Asthma and chronic obstructive pulmonary disease (COPD) are highly prevalent, chronic, diseases [1, 2]. Asthma symptoms usually start at a young age, whereas COPD generally becomes symptomatic after the fourth decade of life. It has been recognised in clinical practice and by international asthma and COPD guidelines [1, 2] that many people have clinical features compatible with both diseases; the term suggested to describe this is ACOS (asthma–COPD overlap syndrome). However, the underlying mechanisms of ACOS and its appropriate treatment are unclear, particularly since these patients have been excluded from studies ...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Postma, D. S., van den Berge, M. Tags: COPD and smoking Editorials Source Type: research

Network analysis: a way forward for understanding COPD multimorbidity
Patients with chronic obstructive pulmonary disease (COPD) often suffer other concomitant diseases that negatively impact their prognosis and health status [1]. However, it is unclear if they are causally related to COPD or result from shared risk factors, such as ageing, smoking and/or inactivity [2]. Likewise, the precise underlying molecular mechanisms are also unclear [3], hence limiting targeted therapeutic interventions. The use of network analysis can help to elucidate this conundrum [4]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Faner, R., Agusti, A. Tags: COPD and smoking Editorials Source Type: research

When small is better: volume reduction in severe emphysema
Severe emphysema radically diminishes quality of life. The disease is a result of destruction of lung parenchyma and is most commonly associated with cigarette smoke exposure or the congenital absence of α1-antitrypsin. The elastic fibres of the lung, which in a healthy state strive to retract the lungs, are particularly affected. The inward force determined by these fibres is balanced by the chest wall, which strives to push outwards. The result is a finely balanced system where only minimal work is needed in quiet breathing. Emphysema results in a loss of elasticity of the lungs, and thus the inward traction, while...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Folch, E., Hillerdal, G. Tags: COPD and smoking Editorials Source Type: research

Improving palliative care for patients with COPD
High quality palliative care for patients with chronic obstructive pulmonary disease (COPD) remains a major challenge in our modern healthcare systems throughout the world. The World Health Organization (WHO) defines palliative care as "the active total care of patients whose disease is not responsive to curative treatment" [1], a definition that certainly describes the care for patients with COPD. The WHO goes on to say that this care should include "an approach that improves the quality of life of patients and their families ... through the prevention and relief of suffering by means of early identification and impeccabl...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Diaz-Lobato, S., Smyth, D., Curtis, J. R. Tags: COPD and smoking Editorials Source Type: research

Untying the Gordian knot: unravelling what influences quality of life in asthma patients
Readers of the European Respiratory Journal are well aware that asthma is an important healthcare concern. Current treatments include glucocorticoids, leukotriene antagonists, long-acting bronchodilators, monoclonal antibodies directed at interleukin (IL)5, IgE, and IL13, and a degree of chemotherapy in cost and degree of complexity becoming close kin to individualised treatment for cancer, and yet hospitalisation and emergency care with substantial impact on quality of life continues. Alexander has yet to winter at Gordium, unsheathe his sword and slice the knot. In this issue of the European Respiratory Journal, Stucky e...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Turner, R. R., Landon, C. Tags: Asthma and allergy Editorials Source Type: research

Protecting children from second-hand smoke
Since the 1970s, we have known that second-hand smoke (SHS) makes children sick, but we have only recently begun to quantify tobacco-related ill health, and to monitor the effects of public health interventions. In this issue of the European Respiratory Journal, Been et al. [1] quantify, for the first time, the effects of smoke-free legislation on hospitalisations for paediatric respiratory infections. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Kuehni, C. E., Barben, J. Tags: COPD and smoking, Paediatric pulmonology Editorials Source Type: research

Idiopathic pulmonary fibrosis: tracking the true occurrence is challenging
Tracking patterns of disease incidence and mortality is fundamental to disease control. The story of lung cancer is exemplary; the 20th century epidemic of lung cancer was first detected in western countries as mortality rates rose; initially it affected males more than females; and rates were not uniform across regions and between countries [1]. The epidemiological studies, motivated by the changing patterns of lung cancer occurrence, identified smoking, and occupational and environmental agents as causes of this highly fatal malignancy. Lung cancer mortality rates, which are very close to incidence rates because of the h...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Samet, J. M., Coultas, D., Raghu, G. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Missing data in IPF trials: do not let methodological issues undermine a major therapeutic breakthrough
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disorder associated with a poor prognosis. Until recently, there has been limited evidence that any drug could alter the course of the disease [1]. However, thanks to worldwide cooperative efforts, large randomised controlled trials have recently demonstrated the efficacy of pirfenidone and nintedanib in slowing down the course of IPF [2–4]. After decades of disappointing results in a number of clinical trials, these robust, groundbreaking studies now give patients with IPF the choice of safe and effective therapeutic options. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Thabut, G., Crestani, B., Porcher, R., Richeldi, L. Tags: Interstitial and orphan lung disease Editorials Source Type: research

Focus on prevention and treatment of obstructive sleep disordered breathing in childhood
In this issue of the European Respiratory Journal, treatment outcomes of obstructive sleep apnoea syndrome (OSAS) in obese community-dwelling children are reported by Alonso-Álvarez et al. [1]. The results of the NANOS multicentre trial indicate that obese children have a high rate of persistent disease despite treatment with adenotonsillectomy, nutritional interventions or even nasal continuous positive airway pressure (CPAP). OSAS is the most severe form of obstructive sleep disordered breathing (SDB), which is a syndrome of upper airway dysfunction during sleep characterised by snoring and increased respiratory e...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Kaditis, A., Levy, P. Tags: Sleep medicine Editorials Source Type: research

{beta}-blockers in pulmonary arterial hypertension: evolving concepts of right heart failure
Current guidelines advise against the use of β-blockers in pulmonary arterial hypertension (PAH) to avoid systemic hypotension [1]. In addition, PAH patients have a fixed stroke volume, and are therefore highly dependent on heart rate to increase their cardiac output [2–4]. Indeed, Provencher et al. [5] showed that withdrawal of β-blockers significantly improved exercise capacity in portopulmonary hypertension. Peacock and Ross [6] described another case of portopulmonary hypertension, in which the use of a β-blocker to treat a supraventricular tachycardia in an already haemodynamically unstable patien...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: de Man, F. S., Handoko, M. L. Tags: Pulmonary vascular disease Editorials Source Type: research

A summary of the new GINA strategy: a roadmap to asthma control
This article provides a summary of key changes in the GINA report, and their rationale. The changes include a revised asthma definition; tools for assessing symptom control and risk factors for adverse outcomes; expanded indications for inhaled corticosteroid therapy; a framework for targeted treatment based on phenotype, modifiable risk factors, patient preference, and practical issues; optimisation of medication effectiveness by addressing inhaler technique and adherence; revised recommendations about written asthma action plans; diagnosis and initial treatment of the asthma–chronic obstructive pulmonary disease ov...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Reddel, H. K., Bateman, E. D., Becker, A., Boulet, L.-P., Cruz, A. A., Drazen, J. M., Haahtela, T., Hurd, S. S., Inoue, H., de Jongste, J. C., Lemanske, R. F., Levy, M. L., O'Byrne, P. M., Paggiaro, P., Pedersen, S. E., Pizzichini, E., Soto-Quiroz, M., Sz Tags: Asthma and allergy GINA Strategy Report Source Type: research

COPD comorbidities network
Multimorbidity frequently affects the ageing population and their co-existence may not occur at random. Understanding their interactions and that with clinical variables could be important for disease screening and management. In a cohort of 1969 chronic obstructive pulmonary disease (COPD) patients and 316 non-COPD controls, we applied a network-based analysis to explore the associations between multiple comorbidities. Clinical characteristics (age, degree of obstruction, walking, dyspnoea, body mass index) and 79 comorbidities were identified and their interrelationships quantified. Using network visualisation software, ...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Divo, M. J., Casanova, C., Marin, J. M., Pinto-Plata, V. M., de-Torres, J. P., Zulueta, J. J., Cabrera, C., Zagaceta, J., Sanchez-Salcedo, P., Berto, J., Davila, R. B., Alcaide, A. B., Cote, C., Celli, B. R., The BODE Collaborative Group Tags: COPD and smoking Original Articles: COPD Source Type: research

A randomised trial of lung sealant versus medical therapy for advanced emphysema
Uncontrolled pilot studies demonstrated promising results of endoscopic lung volume reduction using emphysematous lung sealant (ELS) in patients with advanced, upper lobe predominant emphysema. We aimed to evaluate the safety and efficacy of ELS in a randomised controlled setting. Patients were randomised to ELS plus medical treatment or medical treatment alone. Despite early termination for business reasons and inability to assess the primary 12-month end-point, 95 out of 300 patients were successfully randomised, providing sufficient data for 3- and 6-month analysis. 57 patients (34 treatment and 23 control) had efficacy...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Come, C. E., Kramer, M. R., Dransfield, M. T., Abu-Hijleh, M., Berkowitz, D., Bezzi, M., Bhatt, S. P., Boyd, M. B., Cases, E., Chen, A. C., Cooper, C. B., Flandes, J., Gildea, T., Gotfried, M., Hogarth, D. K., Kolandaivelu, K., Leeds, W., Liesching, T., M Tags: COPD and smoking Original Articles: COPD Source Type: research

Palliative care needs in COPD patients with or without cancer: an epidemiological study
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality worldwide. However, many patients with severe COPD do not receive adequate palliative care. The main goals of our study were to identify the percentage of hospital patients with palliative care needs, particularly those who suffer from COPD. Data were collected prospectively from inpatients at the University Medical Centre Freiburg (Freiburg, Germany). Based on the World Health Organization definition of palliative care, the treating physician reported for each patient discharged whether the patient had palliative care needs or not. ...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Meffert, C., Hatami, I., Xander, C., Becker, G. Tags: COPD and smoking Original Articles: COPD Source Type: research

Asthma, COPD and overlap syndrome: a longitudinal study in young European adults
We compared risk factors and clinical characteristics, 9-year lung function change and hospitalisation risk across subjects with the asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS), asthma or COPD alone, or none of these diseases. Participants in the European Community Respiratory Health Survey in 1991–1993 (aged 20–44 years) and 1999–2001 were included. Chronic airflow obstruction was defined as pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity<lower limit of normal on both occasions. Based on their history of respiratory sympto...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: de Marco, R., Marcon, A., Rossi, A., Anto, J. M., Cerveri, I., Gislason, T., Heinrich, J., Janson, C., Jarvis, D., Kuenzli, N., Leynaert, B., Probst-Hensch, N., Svanes, C., Wjst, M., Burney, P. Tags: COPD and smoking, Asthma and allergy Original Articles: COPD and asthma Source Type: research

Understanding asthma-specific quality of life: moving beyond asthma symptoms and severity
This study identifies the unique contributions of asthma severity, symptoms, control and generic measures of quality of life (QoL) to asthma-specific QoL, as measured by the 12-item RAND Negative Impact of Asthma on Quality of Life scale (RAND-IAQL-12). Using a sample of 2032 adults with asthma, we conducted multiple regression analyses that sequentially examined hypothesised predictors of asthma-specific QoL. The change in variance accounted for and total unique variance accounted for is calculated as hypothesised predictors are added in each step. Our results indicate that asthma severity and asthma symptoms are strong p...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Stucky, B. D., Sherbourne, C. D., Edelen, M. O., Eberhart, N. K. Tags: Asthma and allergy Original Articles: Asthma Source Type: research

Biomarkers to identify sputum eosinophilia in different adult asthma phenotypes
Several biomarkers have been used to assess sputum eosinophilia in asthma. It has been suggested that the diagnostic accuracy of these biomarkers might differ between asthma phenotypes. We investigated the accuracy of biomarkers in detecting sputum eosinophilia (≥3%) in different adult asthma phenotypes. Levels of eosinophils in blood and sputum, exhaled nitric oxide fraction (FeNO) and total immunoglobulin (Ig)E from 336 adult patients, enrolled in three prospective observational clinical trials and recruited at five pulmonology outpatient departments, were analysed. Areas under the receiver operating characteristics c...
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Westerhof, G. A., Korevaar, D. A., Amelink, M., de Nijs, S. B., de Groot, J. C., Wang, J., Weersink, E. J., ten Brinke, A., Bossuyt, P. M., Bel, E. H. Tags: Asthma and allergy Original Articles: Asthma Source Type: research