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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Cystic Fibrosis
This article reviews the current understanding of infection and inflammation and their roles in CF lung disease. It also discusses how this constantly evolving information is used to inform current therapeutic strategies, measures and predictors of disease severity, and research priorities. (Source: Pediatric Clinics of North America)
Source: Pediatric Clinics of North America - July 26, 2016 Category: Pediatrics Authors: Edith T. Zemanick, Lucas R. Hoffman Source Type: research

Serum Triglyceride Level: A Predictor of Complications and Outcomes in Acute Pancreatitis?
Conclusion. A triglyceride level of ≥2.26 mmol/L on admission in acute pancreatitis is an independent predictor of developing local and systemic complications, hospital LOS, admission to ICU, and ICU LOS. PMID: 27446870 [PubMed - in process] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - July 26, 2016 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Potential role of the N-MYC downstream-regulated gene family in reprogramming cancer metabolism under hypoxia.
Authors: Lee GY, Chun YS, Shin HW, Park JW Abstract Metabolic reprogramming toward aerobic glycolysis and lactate fermentation supplies cancer cells with intermediate metabolites, which are used as macromolecule precursors. The oncogene MYC contributes to such aerobic metabolism by activating the expression of numerous genes essential for glycolysis and mitochondrial biogenesis. However, to survive and evolve in a hypoxic tumor milieu, cancer cells must revise MYC-driven metabolism because the mitochondrial respiratory chain provides free electrons to generate oxygen free radicals with inefficient production of ATP...
Source: Oncotarget - July 26, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Late Causes of Death After Pediatric  Cardiac Surgery A 60-Year Population-Based Study
Conclusions < /div > CHD-related deaths have decreased markedly but remain a challenge after surgery for severe cardiac defects. Premature deaths are generally more common among patients than the control population, warranting long-term follow-up after congenital cardiac surgery. < /span > (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - July 26, 2016 Category: Cardiology Source Type: research

Composition of the Sepsis Definitions Task Force
< span class="paragraphSection" > < strong > To the Editor < /strong > We were disappointed to see that the Sepsis-3 consensus panel, convened with the support of major US and international critical care societies to formulate new definitions for sepsis and septic shock, included no women, no underrepresented minority members, and no members from developing countries. This panel followed another invited consensus group convened a few years ago to address the definition of the acute respiratory distress syndrome that included only 1 woman out of 15 task force members and lacked representation from countries beyond North Ame...
Source: JAMA - July 26, 2016 Category: Journals (General) Source Type: research

Re-biopsy by endobronchial ultrasound procedures for mutation analysis of non-small cell lung cancer after EGFR tyrosine kinase inhibitor treatment
Re-biopsy for resistant non-small cell lung cancer (NSCLC) after treatment with epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) is important for selection of better therapy, but there h... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - July 26, 2016 Category: Respiratory Medicine Authors: Takehiro Izumo, Yuji Matsumoto, Christine Chavez and Takaaki Tsuchida Source Type: research

Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases
Emphysema is characterised by distinct pathological sub-types, but little is known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are proteolytic enzymes that can degrade the extrac... (Source: Respiratory Research)
Source: Respiratory Research - July 26, 2016 Category: Respiratory Medicine Authors: Kristoffer Ostridge, Nicholas Williams, Viktoriya Kim, Stephen Harden, Simon Bourne, Ngaire A. Coombs, Paul T. Elkington, Raul San Jose Estepar, George Washko, Karl J. Staples and Tom M. A. Wilkinson Source Type: research

Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased approach to identify pathways activated in bronchoalveolar ... (Source: Respiratory Research)
Source: Respiratory Research - July 26, 2016 Category: Respiratory Medicine Authors: Sina A. Gharib, Anagha Malur, Isham Huizar, Barbara P. Barna, Mani S. Kavuru, Lynn M. Schnapp and Mary Jane Thomassen Source Type: research

Cigarette smoke alters the ability of human dendritic cells to promote anti-Streptococcus pneumoniae Th17 response
Chronic obstructive pulmonary disease (COPD) is associated with chronic inflammation and impaired immune response to pathogens leading to bacteria-induced exacerbation of the disease. A defect in Th17 cytokine... (Source: Respiratory Research)
Source: Respiratory Research - July 26, 2016 Category: Respiratory Medicine Authors: Olivier Le Rouzic, Bachirou Kon é, Jerome Kluza, Philippe Marchetti, Florence Hennegrave, Cécile Olivier, Gwenola Kervoaze, Eva Vilain, Clémence Mordacq, Nicolas Just, Thierry Perez, Nathalie Bautin, Muriel Pichavant and Philippe Gosset Source Type: research

Textiloma: A forgotten diagnosis
Publication date: Available online 25 July 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): E. Marchiori, L.F. Nobre, G. Zanetti (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - July 26, 2016 Category: Respiratory Medicine Source Type: research

Bovine colostrum supplementation and upper respiratory symptoms during exercise training: a systematic review and meta-analysis of randomised controlled trials
Conclusions < /h3 > < p class= " a-plus-plus " > The present systematic review and meta-analysis provides evidence that bovine colostrum supplementation may be effective in preventing the incidence of URS days and episodes in adults engaged in exercise training. The fact that the majority of included studies did not report significant effects on URS outcomes mitigates concerns about publication bias. The point estimates of the random-effects meta-analyses are greater than the smallest clinically important difference, but the low precision of the individual study estimates means the evidence presented in this review needs t...
Source: BMC Sports Science, Medicine and Rehabilitation - July 26, 2016 Category: Sports Medicine Source Type: research

Pleuro-pulmonary blastoma presenting as a chest wall deformity: a case report
Publication date: Available online 23 June 2016 Source:Journal of Pediatric Surgery Case Reports Author(s): Josefina Sáez B., Juan Carlos Pattillo S., José Fernando Vuletin S. Pleuropulmonary blastoma (PPB) is the most common primary malignancy of the lungs in childhood. It occurs more frequently in children between the ages of 1 and 4 and respiratory symptoms are a common manifestation. Three pathologic types have been defined (type I, II and III), which are related to survival and prognosis. Our case report presents a 1-year old boy who was found to have a chest wall deformity at 10 months of age. Imaging revealed...
Source: Journal of Pediatric Surgery Case Reports - July 26, 2016 Category: Surgery Source Type: research

Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism
Conclusion < /h3 > < p class= " a-plus-plus " > This study demonstrates age-associated susceptibility to ALI-induced muscle wasting which parallels a metabolomic profile suggestive of altered muscle fatty acid metabolism. MuRF1 activation may contribute to both atrophy and impaired fatty acid oxidation, which may synergistically impair muscle function in old ALI mice. < /p > < /span > (Source: Metabolomics)
Source: Metabolomics - July 26, 2016 Category: Biology Source Type: research

Air breathing and aquatic gas exchange during hypoxia in armoured catfish
< h3 class= " a-plus-plus " > Abstract < /h3 > < p class= " a-plus-plus " > Air breathing in fish is commonly believed to have arisen as an adaptation to aquatic hypoxia. The effectiveness of air breathing for tissue O < sub class= " a-plus-plus " > 2 < /sub > supply depends on the ability to avoid O < sub class= " a-plus-plus " > 2 < /sub > loss as oxygenated blood from the air-breathing organ passes through the gills. Here, we evaluated whether the armoured catfish ( < em class= " a-plus-plus " > Hypostomus aff. pyreneusi < /em > ) —a facultative air breather—can avoid branchial O < sub class= " a-plus-plus " > 2 < /...
Source: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology - July 26, 2016 Category: Physiology Source Type: research

Congestive heart failure caused by transvenous pacemaker lead prolapse and associated right ventricular outflow tract obstruction in a dog
Publication date: Available online 25 July 2016 Source:Journal of Veterinary Cardiology Author(s): D.M. Djani, A.E. Coleman, G.S. Rapoport, C.W. Schmiedt, J. Layher, J.D. Thomason A 16-year-old dog was presented for cough as well as increased respiratory rate and effort three years after implantation of a single-lead transvenous artificial pacemaker system. Thoracic radiographs and echocardiography disclosed prolapse of the pacemaker lead into the main pulmonary artery, causing severe pulmonary insufficiency and right-sided volume overload. Repositioning of the pacemaker lead led to improvement of pulmonary insuffi...
Source: Journal of Veterinary Cardiology - July 26, 2016 Category: Veterinary Research Source Type: research

Effect of cognitive enrichment on behavior, mucosal immunity and upper respiratory disease of shelter cats rated as frustrated on arrival
Publication date: Available online 26 July 2016 Source:Preventive Veterinary Medicine Author(s): Nadine Gourkow, Clive J.C. Phillips Acquisition of resources and opportunity to engage in natural behaviors has been shown to reduce frustration-related behaviors and enhance health in nondomestic felids kept in zoos, but little is known about whether there are similar effects in domestic cats living in confinement in animal shelters. Fifteen cats rated as Frustrated during the first hour of confinement to a cage at an animal shelter were assigned to either a Treatment (n=7) or Control (n=8) group. Treatment cats were taken...
Source: Preventive Veterinary Medicine - July 26, 2016 Category: Veterinary Research Source Type: research

Molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease
Publication date: 30 August 2016 Source:Veterinary Microbiology, Volume 192 Author(s): Nicola Decaro, Viviana Mari, Vittorio Larocca, Michele Losurdo, Gianvito Lanave, Maria Stella Lucente, Marialaura Corrente, Cristiana Catella, Stefano Bo, Gabriella Elia, Giorgio Torre, Erika Grandolfo, Vito Martella, Canio Buonavoglia A molecular survey for traditional and emerging pathogens associated with canine infectious respiratory disease (CIRD) was conducted in Italy between 2011 and 2013 on a total of 138 dogs, including 78 early acute clinically ill CIRD animals, 22 non-clinical but exposed to clinically ill CIR...
Source: Veterinary Microbiology - July 26, 2016 Category: Veterinary Research Source Type: research

Inactivated porcine reproductive and respiratory syndrome virus vaccine adjuvanted with Montanide ™ Gel 01 ST elicits virus-specific cross-protective inter-genotypic response in piglets
Publication date: 30 August 2016 Source:Veterinary Microbiology, Volume 192 Author(s): Kairat Tabynov, Abylay Sansyzbay, Zhanara Tulemissova, Kaissar Tabynov, Santosh Dhakal, Aigul Samoltyrova, Gourapura J. Renukaradhya, Muratbay Mambetaliyev The efficacy of a novel BEI-inactivated porcine reproductive and respiratory syndrome virus (PRRSV) candidate vaccine in pigs, developed at RIBSP Republic of Kazakhstan and delivered with an adjuvant Montanide™ Gel 01 ST (D/KV/ADJ) was compared with a commercial killed PRRSV vaccine (NVDC-JXA1, C/KV/ADJ) used widely in swine herds of the Republic of Kazakhstan. Clinical pa...
Source: Veterinary Microbiology - July 26, 2016 Category: Veterinary Research Source Type: research

Evaluation of a 20year old porcine reproductive and respiratory syndrome (PRRS) modified live vaccine (Ingelvac ® PRRS MLV) against two recent type 2 PRRS virus isolates in South Korea
This study demonstrates that the PRRS MLV used in this study is still effective against recently isolated heterologous type 2 PRRSV strains even after 20 years of use in over 35 million pigs (Source: Veterinary Microbiology)
Source: Veterinary Microbiology - July 26, 2016 Category: Veterinary Research Source Type: research

Molecular characterization of a feline calicivirus isolated from tiger and its pathogenesis in cats
In this study, the FCV TIG-1 was isolated from Siberian tiger feces collected in 2014 in Heilongjiang Province, China. Phylogenetic analysis among TIG-1 and other FCVs showed that TIG-1 does not share the same lineage with other FCV isolates from Heilongjiang or other regions in China but is located in the same cluster with the FCV strain Urbana, which was isolated from the United States. The growth kinetics in vitro and the pathogenicity in cats between TIG-1 and the domestic cat-origin FCV strain F9 (vaccine strain) and strain 2280 were compared. We found that the growth kinetics of strains TIG-1 and 2280 were faster tha...
Source: Veterinary Microbiology - July 26, 2016 Category: Veterinary Research Source Type: research

Maternally-derived antibodies (MDAs) impair piglets ’ humoral and cellular immune responses to vaccination against porcine reproductive and respiratory syndrome (PRRS)
Publication date: Available online 25 July 2016 Source:Veterinary Microbiology Author(s): C. Fablet, P. Renson, F. Eono, S. Mahé, E. Eveno, M. Le Dimna, V. Normand, A. Lebret, N. Rose, O. Bourry The influence of maternally-derived antibodies (MDAs) on the post-vaccination humoral and cellular immune responses in piglets vaccinated against PRRS was studied. The piglets came from a vaccinated breeding herd. Thirty piglets with a low (A-) or high level (A+) of PRRSV-neutralizing MDAs were vaccinated (V+) with a modified live vaccine at 3 weeks of age. Blood samples were collected before vaccination and then at 2,...
Source: Veterinary Microbiology - July 26, 2016 Category: Veterinary Research Source Type: research

MERS-CoV spike protein: Targets for vaccines and therapeutics
Publication date: Available online 26 July 2016 Source:Antiviral Research Author(s): Qihui Wang, Gary Wong, Guangwen Lu, Jinghua Yan, George F. Gao The disease outbreak caused by Middle East respiratory syndrome coronavirus (MERS-CoV) is still ongoing in the Middle East. Over 1600 people have been infected since it was first reported in September 2012. Despite great efforts, licensed vaccines or therapeutics against MERS-CoV remain unavailable. The MERS-CoV spike (S) protein is an important viral antigen known to mediate host-receptor binding and virus entry, as well as induce robust humoral and cell-mediated respon...
Source: Antiviral Therapy - July 26, 2016 Category: Virology Source Type: research

Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique
ConclusionsRV‐A and RV‐C were the most common respiratory viruses identified in children hospitalised with clinical pneumonia in Manhiça. Clinical presentation of RV‐A and RV‐C was similar and overlapping. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - July 26, 2016 Category: Tropical Medicine Authors: Alicia A. Annamalay, Miguel Lanaspa, Siew ‐Kim Khoo, Lola Madrid, Sozinho Acácio, Guicheng Zhang, Ingrid A. Laing, James Gern, Jack Goldblatt, Joelene Bizzintino, Deborah Lehmann, Peter N. Le Souëf, Quique Bassat Tags: Original Article Source Type: research

Importance of a Travel History in Evaluation of Respiratory Infections
< h3 class= " a-plus-plus " > Abstract < /h3 > < span class= " a-plus-plus abstract-section id-a-sec1 " > < h3 class= " a-plus-plus " > Purpose of Review < /h3 > < p class= " a-plus-plus " > International travel has increased at a fast pace and will continue to rapidly rise. Concomitantly, with this increase in travel is the increase in post travel-related diseases, such as respiratory illnesses. Identifying the cause of the posttravel respiratory illness is a complex challenge for many healthcare professionals because similar presentations occur for both infectious and noninfectious causes. Not only is diagnosis important...
Source: Current Emergency and Hospital Medicine Reports - July 26, 2016 Category: Emergency Medicine Source Type: research

Chronic Invasive Pulmonary Aspergillosis in Two Cats with Diabetes Mellitus
Publication date: Available online 25 July 2016 Source:Journal of Comparative Pathology Author(s): R.V. Leite-Filho, G. Fredo, C.G. Lupion, A. Spanamberg, G. Carvalho, L. Ferreiro, D. Driemeier, S.P. Pavarini, L. Sonne Human patients with diabetes mellitus are at increased risk of fungal infections. Diabetes mellitus has also been implicated as a predisposing factor in the establishment of fungal lung infections in cats. Two diabetic cats of different origins presented with severe acute respiratory conditions that resulted in their death. At necropsy examination there was friable, black material in the main bron...
Source: Journal of Comparative Pathology - July 26, 2016 Category: Pathology Source Type: research

Optimal configuration of respiratory navigator gating for the quantification of left ventricular strain using spiral cine displacement encoding with stimulated echoes (DENSE) MRI
ConclusionWhen quantifying left ventricular strains using spiral cine DENSE MRI, a dual navigator configuration results in the highest SNR in adults and children. In adults, a retrospective configuration has good navigator efficiency without a substantial drop in SNR. Prospective gating should be avoided because it has the lowest SNR. Visual feedback represents an effective option to maintain navigator efficiency while using a dual navigator configuration. J. Magn. Reson. Imaging 2016. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - July 26, 2016 Category: Radiology Authors: Sean M. Hamlet, Christopher M. Haggerty, Jonathan D. Suever, Gregory J. Wehner, Kristin N. Andres, David K. Powell, Brandon K. Fornwalt Tags: Original Research Source Type: research

Early ‐term deliveries as an independent risk factor for long‐term respiratory morbidity of the offspring
ConclusionDeliveries occurring at early term are associated with higher rates of pediatric respiratory hospitalizations compared with full and late‐term deliveries. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 26, 2016 Category: Respiratory Medicine Authors: Asnat Walfisch, Ofer Beharier, Tamar Wainstock, Ruslan Sergienko, Daniella Landau, Eyal Sheiner Tags: Original Article Source Type: research

Perspective on cystic fibrosis and physical activity: Is there a difference compared to healthy individuals?
ConclusionsWhile we found similar levels of physical activity measured by accelerometry in patients with CF compared to healthy controls in general, young school‐aged children showed less engagement in strenuous activities than their healthy counterparts. As the reduced physical activity in young school children was not likely to be explained by the disease state, strenuous physical activity may be enhanced by advocating exercise and sport. Pediatr Pulmonol. 2016; 9999:1–11. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 26, 2016 Category: Respiratory Medicine Authors: Anika Jantzen, Miriam Opoku ‐Pare, Christian Bieli, Katharina Ruf, Helge Hebestreit, Alexander Moeller Tags: Original Article Source Type: research

Asthma after bronchiolitis: The outcome and risk factors depend on the age definition of bronchiolitis
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 26, 2016 Category: Respiratory Medicine Authors: Matti Korppi Tags: Letter to the Editor Source Type: research

Sweat chloride testing: controversies and issues
Publication date: August 2016 Source:The Lancet Respiratory Medicine, Volume 4, Issue 8 Author(s): Martin Kharrazi, Carlos Milla, Jeff Wine (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

Data security in the brave new world of eHealth
Publication date: August 2016 Source:The Lancet Respiratory Medicine, Volume 4, Issue 8 Author(s): Dara Mohammadi (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

Medicine and Me: a breath of fresh air for IPF
Publication date: August 2016 Source:The Lancet Respiratory Medicine, Volume 4, Issue 8 Author(s): Toby Maher (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

A marble sculpture
Publication date: August 2016 Source:The Lancet Respiratory Medicine, Volume 4, Issue 8 Author(s): Jayne Wilton (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial
Publication date: Available online 25 July 2016 Source:The Lancet Respiratory Medicine Author(s): Donald P Tashkin, Michael D Roth, Philip J Clements, Daniel E Furst, Dinesh Khanna, Eric C Kleerup, Jonathan Goldin, Edgar Arriola, Elizabeth R Volkmann, Suzanne Kafaja, Richard Silver, Virginia Steen, Charlie Strange, Robert Wise, Fredrick Wigley, Maureen Mayes, David J Riley, Sabiha Hussain, Shervin Assassi, Vivien M Hsu, Bela Patel, Kristine Phillips, Fernando Martinez, Jeffrey Golden, M Kari Connolly, John Varga, Jane Dematte, Monique E Hinchcliff, Aryeh Fischer, Jeffrey Swigris, Richard Me...
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

Scleroderma Lung Study II —clarity or obfuscation?
Publication date: Available online 25 July 2016 Source:The Lancet Respiratory Medicine Author(s): Christopher P Denton (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 26, 2016 Category: Respiratory Medicine Source Type: research

Perinatal features of congenital cystic lung diseases: results of a nationwide multicentric study in Japan
Conclusions < /h3 > < p class= " a-plus-plus " > An estimated 8 –9 % of prenatally diagnosed patients carry the highest risk of perinatal respiratory distress. Fetal LVR remaining at a high level during the late gestational period seems to predict a high risk. < /p > < /span > (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - July 26, 2016 Category: Surgery Source Type: research

Expectant management with close monitoring of mother and neonate should be practised after late preterm prelabour rupture of membranes
Commentary on: Morris JM, Roberts CL, Bowen JR, et al.. Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term (PPROMT trial): a randomised controlled trial. Lancet 2016;387:444–52 . Context Preterm prelabour rupture of membranes (PPROM) affects 2–5% of all pregnancies and accounts for 40% of all preterm deliveries. It is associated with maternal and perinatal morbidity and mortality.1 There is good evidence and consensus that immediate delivery at term will improve outcome and maternal satisfaction. In PPROM prior to 34 0/7 weeks, risks of pre...
Source: Evidence-Based Medicine - July 26, 2016 Category: Internal Medicine Authors: van der Ham, D. P. Tags: Clinical trials (epidemiology), Epidemiologic studies, Pregnancy Therapeutics/Prevention Source Type: research

The Mitochondrial Unfolded Protein Response Protects against Anoxia in < i > Caenorhabditis elegans < /i >
< p > by Salvador Pe ña, Teresa Sherman, Paul S. Brookes, Keith Nehrke < /p > The mitochondrial unfolded protein response (UPR < sup > mt < /sup > ) is a surveillance pathway that defends proteostasis in the “powerhouse” of the cell. Activation of the UPR < sup > mt < /sup > protects against stresses imposed by reactive oxygen species, respiratory chain deficits, and pathologic bacteria. Consistent with the UPR < sup > mt < /sup > ’s role in adaption, we found that either its pharmacological or genetic activation by ethidium bromide (EtBr) or RNAi of the mitochondrial AAA-protease < i > spg-7 < /i > was sufficient...
Source: PLoS One - July 26, 2016 Category: Biomedical Science Authors: Salvador Pe ña Source Type: research

Reasons doctors provide futile treatment at the end of life: a qualitative study
Conclusions Doctors believe that a range of factors contribute to the provision of futile treatment. A combination of strategies is necessary to reduce futile treatment, including better training for doctors who treat patients at the end of life, educating the community about the limits of medicine and the need to plan for death and dying, and structural reform at the hospital level. (Source: Journal of Medical Ethics)
Source: Journal of Medical Ethics - July 26, 2016 Category: Medical Ethics Authors: Willmott, L., White, B., Gallois, C., Parker, M., Graves, N., Winch, S., Callaway, L. K., Shepherd, N., Close, E. Tags: Emergency medicine, End of life decisions (geriatric medicine), End of life decisions (palliative care), Hospice, Adult intensive care, End of life decisions (ethics) Clinical ethics Source Type: research

Cardiac issues in adults with the mucopolysaccharidoses: current knowledge and emerging needs
The growing availability of innovative treatments for rare genetic diseases with a cardiac component—such as the mucopolysaccharidoses (MPSs)—has changed these syndromes from ‘back of the textbook’ curiosities of childhood to chronic, but rare, adult cardiac conditions that require both centres of expertise and knowledgeable subspecialists. The MPSs are inherited progressive lysosomal storage diseases, occurring in about 1:25 000 births and resulting from absence of functional hydrolases responsible for the degradation of glycosaminoglycans, naturally occurring complex sugars ubiquitous through...
Source: Heart - July 26, 2016 Category: Cardiology Authors: Braunlin, E., Wang, R. Tags: Review articles Reviews Source Type: research