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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Anxiety and depression in sarcoidosis: the influence of age, gender, affected organs, concomitant diseases and dyspnea.
CONCLUSIONS: The analysis of mental distress should take into account comparisons with normative values. Young patients deserve special social support. Dyspnea proved to be an important symptom in the prediction of anxiety and depression. PMID: 23461077 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A prospective clinical multicentre study on adult pulmonary Langerhans' cell histiocytosis.
CONCLUSION: The data underline the key role of smoking as the sole known risk factor. A significant effect of smoking cessation on the course could not be confirmed. The overall prognosis was good in this series as compared to previous reports. PMID: 23461076 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Are clinical features in Löfgren's syndrome-related erythema nodosum different from idiopathic erythema nodosum?
CONCLUSIONS: Apart from BHL, arthritis and/or arthralgia especially periarticular ankle inflammation is the feature which could be used to differentiate LS related EN from IEN. There is more need for steroids in LS patients and the symptoms quickly resolve with steroids. PMID: 23461075 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States.
CONCLUSIONS: The analysis indicates that sarcoidosis tends to improve over time in terms of pulmonary function and medication requirements. The disease was found to be more severe in blacks than whites. Treatment was not necessarily required. These results provide a comprehensive model of the course and treatment of sarcoidosis in the clinical setting. PMID: 23461074 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Health-related quality of life does not predict mortality in idiopathic pulmonary fibrosis.
CONCLUSIONS: There was no significant relationship between HRQL evaluated with the SGRQ and the subsequent mortality in IPF. The present negative result might suggest that HRQL is measuring an aspect other than one from physiological and functional impairment or disability. PMID: 23461073 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Six-minute stepper test to assess effort intolerance in interstitial lung diseases.
Authors: Delourme J, Stervinou-Wemeau L, Salleron J, Grosbois JM, Wallaert B Abstract The six-minute stepper test (6MST) is a new test for evaluating exercise tolerance. Unlike the six-minute walk test (6MWT) it can be carried out in a limited space. The aim of this study was to compare the 6MST and the 6MWT in patients with various diffuse interstitial lung disease (ILD). 6MWT and 6MST were performed the same day in 84 patients with various ILD. The covered distance during 6MWT was compared to the number of steps during the 6MST. We also compared heart rate, oxygen saturation, dyspnoea and leg tiredness on a Borg ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Bronchial hyperreactivity in sarcoidosis patients: correlation with airflow limitation indices.
CONCLUSION: BHR occurs frequently in sarcoidosis patients and should be considered especially in patients with airflow limitation. PMID: 23461071 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Endpoints for clinical trials of sarcoidosis.
Authors: Baughman RP, Drent M, Culver DA, Grutters JC, Handa T, Humbert M, Judson MA, Lower EE, Mana J, Pereira CA, Prasse A, Sulica R, Valyere D, Vucinic V, Wells AU Abstract Over the past few years an increasing number of prospective controlled sarcoidosis treatment trials have been completed. Unfortunately, these studies utilize different endpoints making comparisons between studies difficult. At the recent World Association of Sarcoidosis and other Granulomatous disease (WASOG) meeting, a session was dedicated to the evaluation of clinical endpoints for various disease manifestations. These included pulmonary, ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Feasibility of cytological diagnosis of sarcoidosis with endobronchial US-guided transbronchial aspiration.
CONCLUSIONS: Cytological evaluation of the EBUS-TBNA specimens had higher sensitivity than histological evaluation alone for intrathoracic lymphadenopathy due to sarcoidosis. It should be recognized, however, that up to 6% of patients with thoracic malignancy may have sarcoid reaction in non-metastatic lymph nodes. PMID: 23461069 [PubMed - indexed for MEDLINE] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - November 25, 2014 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Correlation between Obstructive Sleep Apnea Syndrome and Cardiac Disease Severity.
Conclusion. Our study found a strong correlation between the number of stenotic vessels and OSA. Based on our findings, OSA can be a predisposing factor for cardiac diseases. PMID: 24701348 [PubMed] (Source: Cardiovascular Psychiatry and Neurology)
Source: Cardiovascular Psychiatry and Neurology - November 25, 2014 Category: Psychiatry Tags: Cardiovasc Psychiatry Neurol Source Type: research

Nutrition in severe dementia.
The objective of this paper is to present methods for evaluating the nutritional status of patients with severe dementia as well as measures for the treatment of nutritional disorders, the use of vitamin and mineral supplementation, and indications for ANH and pharmacological therapy. PMID: 22645608 [PubMed] (Source: Current Gerontology and Geriatrics Research)
Source: Current Gerontology and Geriatrics Research - November 25, 2014 Category: Geriatrics Tags: Curr Gerontol Geriatr Res Source Type: research

Study protocol, implementation, and verification of a short versatile upright exercise regime during 5 days of bed rest.
CONCLUSION: the overall similarity in the response to BR, and increase in upright heart rate during the LRT sessions suggest early and advancing cardiovascular deconditioning during 5 days of BR bed rest, which was not prevented by the versatile exercise regime. PMID: 24583546 [PubMed - indexed for MEDLINE] (Source: Journal of Musculoskeletal Neuronal Interactions)
Source: Journal of Musculoskeletal Neuronal Interactions - November 25, 2014 Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research

Non-muscle involvement in late-onset glycogenosis II.
Authors: Filosto M, Todeschini A, Cotelli MS, Vielmi V, Rinaldi F, Rota S, Scarpelli M, Padovani A Abstract Glycogenosis II (GSD II) is an autosomal recessive lysosomal storage disorder resulting from acid alpha-glucosidase deficiency, subsequent accumulation of glycogen in tissues, impairment of autophagic processes and progressive cardiac, motor and respiratory failure. The late-onset form is characterized by wide variability in residual enzyme activity, age of onset, rate of disease progression and phenotypical spectrum. Although the pathological process mainly affects the skeletal muscle, several other tissues ...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

On a case of respiratory failure due to diaphragmatic paralysis and dilated cardiomyopathy in a patient with nemaline myopathy.
We report a case of a 50-year-old man who presented with severe heart failure as the initial manifestation of nemaline myopathy. Soon after he developed acute restrictive respiratory failure due to the diaphragmatic paralysis. The diagnosis of "nemaline myopathy" was obtained on muscle biopsy performed one year later. After starting appropriate cardiological treatment and non-invasive ventilation, his cardiac and pulmonary functions improved substantially, remaining stable for over the 10 years since diagnosis. In the last two years the patient had a progressive deterioration of respiratory function, enabling him to attend...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Long-term ventilation of patients with Duchenne muscular dystrophy: experiences at the Neuromuscular Centre Ulm.
Authors: Wollinsky KH, Kutter B, Geiger PM Abstract The various measures used to treat the symptoms of Duchenne muscular dystrophy (DMD), i.e. medication with steroids, early operation on contractures and spine deformities as well as cardiac diagnostics and therapy, should always be accompanied by careful monitoring of the patient's respiratory status. Therapy for respiratory failure, in particular long-term ventilation, is now generally accepted as essential for DMD patients. The provision of assisted ventilation has made a decisive contribution to the quality of life for older patients and the stigma hitherto att...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Improvement of survival in Duchenne Muscular Dystrophy: retrospective analysis of 835 patients.
This report documents that DMD should be now considered an adulthood disease as well, and as a consequence more public health interventions are needed to support these patients and their families as they pass from childhood into adult age. PMID: 23097603 [PubMed - indexed for MEDLINE] (Source: Acta Myologica)
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

The heart and cardiac pacing in Steinert disease.
Authors: Nigro G, Papa AA, Politano L Abstract Myotonic dystrophy (Dystrophia Myotonica, DM) is the most frequently inherited neuromuscular disease of adult life. It is a multisystemic disease with major cardiac involvement. Core features of myotonic dystrophy are myotonia, muscle weakness, cataract, respiratory failure and cardiac conduction abnormalities. Classical DM, first described by Steinert and called Steinert's disease or DM1 (Dystrophia Myotonica type 1) has been identified as an autosomal dominant disorder associated with the presence of an abnormal expansion of a CTG trinucleotide repeat in the 3' untra...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy.
Authors: McAdam LC, Mayo AL, Alman BA, Biggar WD Abstract Deflazacort is the most commonly prescribed corticosteroid for the treatment of Duchenne muscular dystrophy in Canada. We review the long-term experience with deflazacort treatment at two centers in Canada; Montreal and Toronto. Deflazacort has benefitted both cohorts by prolonged ambulation, preserved cardiac and respiratory function, less scoliosis and improved survival. Common side effects in both cohorts include weight gain, decreased height and cataract formation. The Canadian experience supports the use of deflazacort in treating boys with Duchenne mus...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Drug treatment of Duchenne muscular dystrophy: available evidence and perspectives.
Authors: Beytía Mde L, Vry J, Kirschner J Abstract Duchenne muscular dystrophy (DMD) is a disease linked to the X-chromosome which affects 1 in 3,600-6,000 newborn males. It is manifested by the absence of the dystrophin protein in muscle fibres, which causes progressive damage leading to death in the third decade of life. The only medication so far shown to be effective in delaying the progression of this illness are corticosteroids, which have been shown to increase muscle strength in randomised controlled studies; long-term studies have demonstrated that they prolong walking time and retard the progression of r...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Cardiological manifestations of mitochondrial respiratory chain disorders.
Authors: Berardo A, Musumeci O, Toscano A Abstract Mitochondrial Respiratory Chain Disorders (MRCD) are a heterogeneous group of disorders that share the involvement of the cellular bioenergetic machinery due to molecular defects affecting the mitochondrial oxidative phosphorylation system (OXPHOS). Clinically, they usually involve multiple tissues although they tend to mainly affect nervous system and skeletal muscle. Cardiological manifestations are frequent and include hypertrophic or dilated cardiomyopathies and heart conduction defects, being part of adult or infantile multisystemic mitochondrial disorders or,...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Pathogenesis and treatment of mitochondrial myopathies: recent advances.
Authors: DiMauro S Abstract In this brief review, I have highlighted recent advances in several areas of mitochondrial medicine, including mtDNA-related diseases, mendelian mitochondrial encephalomyopathies, and therapy. The pathogenic mechanisms of mtDNA mutations, especially those affecting mitochondrial protein synthesis, are still largely unknown. The pathogenicity of homoplasmic mtDNA mutations has become evident but has also called attention to modifying nuclear genes, yet another example of impaired intergenomic signaling. The functional significance of the homoplasmic changes associated with mitochondrial h...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Severe phenotype of a patient with autosomal recessive centronuclear myopathy due to a BIN1 mutation.
Authors: Mejaddam AY, Nennesmo I, Sejersen T Abstract Centronuclear myopathy (CNM) is a rare hereditary congenital myopathy characterized by muscular hypotonia and abnormal centralization of nuclei in muscle fibers. The autosomal recessive (AR) form presents from birth to childhood, followed by a mild progression of muscle weakness. Despite recently identified genetic loci in the AR form, genotype-phenotype correlations are poorly established. Our index case is a 17 year old boy with recessive CNM causing loss of ambulation at 13 years of age and requiring ventilatory assistance nightly. Recent genetic testing reve...
Source: Acta Myologica - November 25, 2014 Category: Neurology Tags: Acta Myol Source Type: research

Analysis of cardiopulmonary stress during endoscopy: is unsedated transnasal esophagogastroduodenoscopy appropriate for elderly patients?
CONCLUSIONS: For elderly patients, unsedated transnasal EGD failed to show an advantage over unsedated standard endoscopy. Transoral thin EGD was estimated to be safe and tolerable. PMID: 24288691 [PubMed - indexed for MEDLINE] (Source: Canadian Journal of Gastroenterology)
Source: Canadian Journal of Gastroenterology - November 25, 2014 Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research

Trema orientalis Linn. Blume: A potential for prospecting for drugs for various uses.
This article is aimed at providing comprehensive information on the medicinal uses, biology, phytochemical constituents, and pharmacological data available on T. orientalis. This has been done to explore its therapeutic potential for future research opportunities. This review was compiled with information obtained from databases such as Medline, Elsevier, Springer, Science Direct, Pubmed, Google Scholar, and a library search for articles published in peer-reviewed journals. Compounds present in the plant include tannins, saponins, flavanoids, triterpenes, phytosterols, and several constituents of xanthones. Some pharmacolo...
Source: Pharmacognosy Reviews - November 25, 2014 Category: Drugs & Pharmacology Tags: Pharmacogn Rev Source Type: research

Borreria and Spermacoce species (Rubiaceae): A review of their ethnomedicinal properties, chemical constituents, and biological activities.
Authors: Conserva LM, Ferreira JC Abstract Borreira and Spermacoce are genera of Rubiaceae widespread in tropical and subtropical America, Africa, Asia, and Europe. Based on its fruits morphology they are considered by many authors to be distinct genera and most others, however, prefer to combine the two taxa under the generic name Spermacoce. Whereas the discussion is still unclear, in this work they were considered as synonyms. Some species of these genera play an important role in traditional medicine in Africa, Asia, Europe, and South America. Some of these uses include the treatment of malaria, diarrheal and o...
Source: Pharmacognosy Reviews - November 25, 2014 Category: Drugs & Pharmacology Tags: Pharmacogn Rev Source Type: research

Epigenetic targets for reversing immune defects caused by alcohol exposure.
Authors: Curtis BJ, Zahs A, Kovacs EJ Abstract Alcohol consumption alters factors that modify gene expression without changing the DNA code (i.e., epigenetic modulators) in many organ systems, including the immune system. Alcohol enhances the risk for developing several serious medical conditions related to immune system dysfunction, including acute respiratory distress syndrome (ARDS), liver cancer, and alcoholic liver disease (ALD). Binge and chronic drinking also render patients more susceptible to many infectious pathogens and advance the progression of HIV infection by weakening both innate and adaptive immuni...
Source: Alcohol Research - November 25, 2014 Category: Addiction Tags: Alcohol Res Source Type: research

Tomographic findings of acute pulmonary toxoplasmosis in immunocompetent patients
Conclusion: These cases provide a unique description of the presentation and evolution of pulmonary tomographic manifestations of toxoplasmosis in immunocompetent patients. Toxoplasma pneumonia manifests with fever, dyspnea and a non-productive cough that may result in respiratory failure. In animal models, changes were described as interstitial pneumonitis with focal infiltrates of neutrophils that can finally evolve into a pattern of diffuse alveolar damage with focal necrosis. The tomographic findings are characterized as ground glass opacities, smooth septal and marked peribronchovascular thickening; and may mimic pulm...
Source: BioMed Central - November 25, 2014 Category: Journals (General) Authors: Karina de Souza GiassiAndre Nathan CostaAndre ApanaviciusFernando Bin TeixeiraCaio Julio FernandesAlfredo Salim HelitoRonaldo Adib Kairalla Source Type: research

Candida albicans brain abscesses in an injection drug user patient: a case report
Conclusion: Despite advances in diagnostic and therapeutic procedures, fungal brain abscess remains a life-threatening disease with a poor outcome. Successful treatment requires an early diagnosis and usually a combined medical and surgical approach. A long-term antibiotic regimen is a cornerstone of fungal brain abscesses treatment, with the endpoint determined by clinical and neuroimaging response. The authors report an uncommon case of successfully treated Candida albicans brain abscesses with anti-fungal therapy consisting of fluconazole alone. This case illustrates the importance of early recognition of predisposing f...
Source: BioMed Central - November 25, 2014 Category: Journals (General) Authors: Nélia NevesLurdes SantosCarina ReisAntónio Sarmento Source Type: research

Dentate gyrus abnormalities in sudden unexplained death in infants: morphological marker of underlying brain vulnerability
Abstract Sudden unexplained death in infants, including the sudden infant death syndrome, is likely due to heterogeneous causes that involve different intrinsic vulnerabilities and/or environmental factors. Neuropathologic research focuses upon the role of brain regions, particularly the brainstem, that regulate or modulate autonomic and respiratory control during sleep or transitions to waking. The hippocampus is a key component of the forebrain–limbic network that modulates autonomic/respiratory control via brainstem connections, but its role in sudden infant death has received little attention. We tested the ...
Source: Acta Neuropathologica - November 25, 2014 Category: Neurology Source Type: research

Importance of radiological detection of early pulmonary acute complications of liver transplantation: analysis of 259 cases
Conclusions Knowledge about postoperative pulmonary complications and collaboration between the radiologist and clinician are essential for improving the management of OLT recipients. (Source: La Radiologia Medica)
Source: La Radiologia Medica - November 25, 2014 Category: Radiology Source Type: research

Age-related reflex responses from peripheral and central chemoreceptors in healthy men
Abstract Objective The study aimed: (i) to characterize reflex responses from peripheral and central chemoreceptors in different age groups of healthy men (<50 years old vs ≥50 years old) and, (ii) to assess, within these groups, whether there is any relationship between ventilatory and hemodynamic responses from chemoreceptors and indices of autonomic nervous system (ANS). Methods Peripheral chemoreflex sensitivity was assessed by the transient hypoxia method and respiratory, heart rate (HR) and blood pressure responses were calculated. Central c...
Source: Clinical Autonomic Research - November 25, 2014 Category: Research Source Type: research

Death is not a lullaby
Publication date: Available online 25 November 2014 Source:The Lancet Respiratory Medicine Author(s): Aaron van Dorn (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 25, 2014 Category: Respiratory Medicine Source Type: research

Correlation between use of simvastatin and lovastatin and female lung cancer risk: a nationwide case–control study
ConclusionsSimvastatin use at a DDD of more than 150 is correlated with an approximately 20% reduction in the risk of lung cancer in women. (Source: International Journal of Clinical Practice)
Source: International Journal of Clinical Practice - November 25, 2014 Category: Internal Medicine Authors: T.‐Y. Yang, W.‐M. Lin, C.‐L. Lin, F.‐C. Sung, C.‐H. Kao Tags: Original Paper Source Type: research

A novel de novo STXBP1 mutation is associated with mitochondrial complex I deficiency and late-onset juvenile-onset parkinsonism
Abstract Mutations in STXBP1 have recently been identified as a cause of infantile epileptic encephalopathy. The underlying mechanism of the disorder remains unclear and, recently, several case reports have described broad and progressive neurological phenotypes in addition to early-onset epilepsy. Herein, we describe a patient with early-onset epilepsy who subsequently developed a progressive neurological phenotype including parkinsonism in her early teens. A de novo mutation in STXBP1 (c.416C>T, p.(Pro139Leu)) was detected with exome sequencing together with profound impairment of complex I of the mitochondri...
Source: Neurogenetics - November 25, 2014 Category: Genetics & Stem Cells Source Type: research

Sleep continuity: a new metric to quantify disrupted hypnograms in non-sedated intensive care unit patients
Conclusion: Sleep continuity measurements could constitute a clinically relevant and reproducible assessment of sleep disruption in non-sedated ICU patients with usual sleep EEG. (Source: Critical Care)
Source: Critical Care - November 25, 2014 Category: Intensive Care Authors: Xavier DrouotAgathe BridouxArnaud ThilleFerran Roche-CampoAna Cordoba-IzquierdoSandrine KatsahianLaurent BrochardMarie-Pia d¿Ortho Source Type: research

Biphasic cuirass ventilation is better than bag-valve mask ventilation for resuscitation following organophosphate poisoning
Conclusions The noninvasive, easy-to-operate Biphasic Cuirass Ventilation device was effective in reducing OP-induced mortality and might be advantageous in an organophosphate mass casualty event. This finding should be validated in further investigations. (Source: Toxicology Reports)
Source: Toxicology Reports - November 25, 2014 Category: Toxicology Source Type: research

A Randomized Trial of Continuous Versus Interrupted Chest Compressions in Out-of-Hospital Cardiac Arrest: Rationale for and Design of the Resuscitation Outcomes Consortium CCC Trial
Publication date: Available online 20 November 2014 Source:American Heart Journal Author(s): Siobhan P. Brown , Henry Wang , Tom P. Aufderheide , Christian Vaillancourt , Robert H. Schmicker , Sheldon Cheskes , Ron Straight , Peter Kudenchuk , Laurie Morrison , Riccardo Colella , Joseph Condle , George Gamez , David Hostler , Tami Kayea , Sally Ragsdale , Shannon Stephens , Graham Nichol The Resuscitation Outcomes Consortium is conducting a randomized trial comparing survival to hospital discharge after continuous chest compressions (CCC) without interruption for ventilation versus currently recommended American Heart As...
Source: American Heart Journal - November 25, 2014 Category: Cardiology Source Type: research

Host–microorganism interactions in lung diseases
Nature Reviews Immunology 14, 827 (2014). doi:10.1038/nri3769 Authors: Benjamin J. Marsland & Eva S. Gollwitzer Until recently, the airways were thought to be sterile unless infected; however, a shift towards molecular methods for the quantification and sequencing of bacterial DNA has revealed that the airways harbour a unique steady-state microbiota. This paradigm shift is changing the way that respiratory research (Source: Nature Reviews Immunology)
Source: Nature Reviews Immunology - November 25, 2014 Category: Allergy & Immunology Authors: Benjamin J. MarslandEva S. Gollwitzer Tags: Perspectives Source Type: research

Peri‐operative adverse respiratory events in children
Summary Three quarters of all critical incidents and a third of all peri‐operative cardiac arrests in paediatric anaesthesia are caused by adverse respiratory events. We screened for risk factors from children's and their families' histories, and assessed the usefulness of common markers of allergic sensitisation of the airway as surrogates for airway inflammation and increased risk for adverse respiratory events. One hundred children aged up to 16 years with two or more risk factors undergoing elective surgery were included in the study. Eosinophil counts, IgE level, specific IgE for D. pteronyssinus, cat epithelia and...
Source: Anaesthesia - November 25, 2014 Category: Anesthesiology Authors: B. S. Ungern‐Sternberg, A. Ramgolam, G. L. Hall, P. D. Sly, W. Habre Tags: Original Article Source Type: research

A Phase 2 Study of Abiraterone Acetate in Japanese Men with Metastatic Castration-resistant Prostate Cancer Who Had Received Docetaxel-based Chemotherapy
Conclusions Abiraterone acetate plus prednisolone showed favorable efficacy in metastatic castration-resistant prostate cancer Japanese patients who had received chemotherapy. Abiraterone acetate plus prednisolone had an acceptable safety profile. Clinical trial registration no NCT01795703. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - November 25, 2014 Category: Cancer & Oncology Authors: Satoh, T., Uemura, H., Tanabe, K., Nishiyama, T., Terai, A., Yokomizo, A., Nakatani, T., Imanaka, K., Ozono, S., Akaza, H. Tags: Urology, Original Articles Source Type: research

FISH Analysis of Intrapulmonary Malignant Mesothelioma without a Clinically Detectable Primary Pleural Lesion: An Autopsy Case
Patients with malignant mesothelioma typically present with a pleural effusion or pleural thickening and masses. A rare autopsy case of mesothelioma presenting with multiple bilateral lung nodules without clinically detectable pleural lesions is presented. A definitive diagnosis of the video-assisted thoracic surgery specimen could not be made, though a pattern of fibrosis mimicking organizing pneumonia was identified. Despite corticosteroid therapy, follow-up chest computed tomography showed enlargement of multiple nodules accompanied by the appearance of pleural thickening and effusions. The patient died of respiratory f...
Source: Japanese Journal of Clinical Oncology - November 25, 2014 Category: Cancer & Oncology Authors: Hasegawa, M., Sakai, F., Sato, A., Tsubomizu, S., Arimura, K., Katsura, H., Koh, E., Sekine, Y., Wu, D., Hiroshima, K. Tags: Case Report Source Type: research

Ethnomedicinal plant use value in the Lakki Marwat District of Pakistan
Conclusion The results of present study reveal that this enormous wealth of medicinal plants played an important role in the health care of the villagers in the study area. In addition, species with high use values (UV) might provide valuable leads for further pharmacological investigations. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - November 25, 2014 Category: Drugs & Pharmacology Source Type: research

Influence of macrolides, nutritional support and respiratory therapies in diabetes and normal glucose tolerance in cystic fibrosis. A retrospective analysis of a cohort of adult and younger patients
Conclusions The anti-inflammatory and immunomodulating effect of macrolides did not seem to affect the β cell function or insulin resistance in patients with cystic fibrosis. The use of inhaled corticosteroids or nutritional supplements have not any influence in the carbohydrate metabolism. Further prospective studies are needed to analyze a potential protective role of macrolides in the development of carbohydrate metabolism alterations in cystic fibrosis. (Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews)
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - November 25, 2014 Category: Endocrinology Source Type: research

Use of Procalcitonin in Patients With Various Degrees of Chronic Kidney Disease Including Renal Replacement Therapy
This article focuses on the use of PCT in patients with various degrees of chronic kidney disease in addition to various forms of dialysis, as chronic kidney disease may alter baseline levels of PCT and thus result in inappropriate use of PCT in this population. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - November 25, 2014 Category: Infectious Diseases Authors: Grace, E., Turner, R. M. Tags: CLINICAL PRACTICE Source Type: research

Clinical Manifestations and Risk Factors Influencing Eradication of Extensive Multidrug-resistant Acinetobacter baumannii from the Respiratory Tract
Conclusion XDRAB eradication from the respiratory tract is associated with improved clinical outcomes. Clinicians should be aware of the possible negative effect of combination therapy with aerosolized colistin and tigecycline for eradicating XDRAB. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 25, 2014 Category: Journals (General) Source Type: research

Interobserver reliability of attending physicians and bedside nurses when using an inpatient paediatric respiratory score
ConclusionsBedside nurses, with support and training from attending physicians, can perform respiratory assessments that agree almost perfectly with those of attending physicians. Relevance to clinical practiceThe use of an Integrated Care Pathway allows for optimal interprofessional collaboration between bedside nurses and attending physicians. (Source: Journal of Clinical Nursing)
Source: Journal of Clinical Nursing - November 25, 2014 Category: Nursing Authors: Eric A. Biondi, Julie Albright Gottfried, Irene Dutko Fioravanti, Jan A. Schriefer, Claude Andrew Aligne, Michael S. Leonard Tags: Original Article Source Type: research

Cost-effectiveness analysis of a low-cost bubble CPAP device in providing ventilatory support for neonates in Malawi ¿ a preliminary report
Background: A low-cost bubble continuous positive airway pressure (bCPAP) device has been shown to be an excellent clinical alternative to nasal oxygen for the care of neonates with respiratory difficulty. However, the delivery of bCPAP requires more resources than the current routine care using nasal oxygen. We performed an economic evaluation to determine the cost-effectiveness of a low-cost bCPAP device in providing ventilatory support for neonates in Malawi. Methods: We used patient-level clinical data from a previously published non-randomized controlled study. Economic data were based on the purchase price of supplie...
Source: BMC Pediatrics - November 25, 2014 Category: Pediatrics Authors: Ariel ChenAshish DeshmukhRebecca Richards-KortumElizabeth MolyneuxKondwani KawazaScott Cantor Source Type: research

Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer
Conclusions: In conclusion, our study suggested that five plasma miRNAs (miR-20a, miR-145, miR-21, miR-223 and miR-221) can be used as promising biomarkers in early screening of NSCLC. Nevertheless, further validation and optimizing improvement should be performed on larger sample to confirm our results. (Source: Respiratory Research)
Source: Respiratory Research - November 25, 2014 Category: Respiratory Medicine Authors: Qing GengTao FanBoyou ZhangWei WangYao XuHao Hu Source Type: research