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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

The promise of translational and personalised approaches for paediatric obstructive sleep apnoea: an 'Omics' perspective
Obstructive sleep apnoea (OSA) can result in significant morbidities including the cardiovascular, metabolic and neurocognitive systems. These effects are purportedly mediated via activation of inflammatory cascades and the induction of oxidative stress, ultimately resulting in cellular injury and dysfunction. While great advances have been made in sleep medicine research in the past decades, there are still wide gaps in our knowledge concerning the exact underlying pathophysiological mechanisms of OSA and consequences. Without resolving these issues, the reasons why patients with a similar severity of OSA can have markedl...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Tan, H.-L., Kheirandish-Gozal, L., Gozal, D. Tags: Epidemiologic studies, Sleep disorders (neurology), Child health, Sleep disorders, Sleep disorders (respiratory medicine) Review Source Type: research

The genomic origins of asthma
Lung function tracks from the earliest age that it can be reliably measured. Genome wide association studies suggest that most variants identified for common complex traits are regulatory in function and active during fetal development. Fetal programming of gene expression during development is critical to the formation of a normal lung. An understanding of how fetal developmental genes related to diseases of the lungs and airways is a critical area for research. This review article considers the developmental origins hypothesis, the stages of normal lung development and a variety of environmental exposures that might infl...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Sharma, S., Chhabra, D., Kho, A. T., Hayden, L. P., Tantisira, K. G., Weiss, S. T. Tags: Asthma, Health education, Smoking, Tobacco use Review Source Type: research

Bronchiolitis obliterans syndrome leads to a functional deterioration of the acinus post lung transplant
ABSTRACT Bronchiolitis obliterans syndrome (BOS) limits long-term survival of lung transplant recipients, and airflow obstruction in these patients likely originates in the small airways. 61 double lung transplant recipients performed multiple breath nitrogen washouts to obtain indices of acinar and conductive ventilation heterogeneity (Sacin, Scond). There was a significant association of BOS status with Sacin (Kruskal–Wallis; p<0.001) but not with Scond (p=0.1). These results demonstrate that it is the structural alteration of the terminal bronchioles, generating ventilation heterogeneity at the level of the dif...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Thompson, B. R., Hodgson, Y. M., Kotsimbos, T., Liakakos, P., Ellis, M. J., Snell, G. I., Verbanck, S. Tags: Bronchiolitis, TB and other respiratory infections, Bronchitis, Interstitial lung disease, Cardiothoracic surgery, Transplantation Research letter Source Type: research

Ambrisentan for pulmonary fibrosis
This randomised, double-blind, placebo-controlled study is one of the largest multicentre studies investigating whether ambrisentan (an endothelin A receptor antagonist) reduces the rate of idiopathic pulmonary fibrosis (IPF) progression. The investigators compared ambrisentan (more commonly used in the treatment of pulmonary hypertension (PH)) with placebo on the basis of preclinical studies suggesting endothelin receptor blockade decreased the severity of pulmonary fibrosis. The primary endpoint was time to IPF progression defined as either death, respiratory hospitalisation or prespecified decrease in lung function (whi...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Punwani, R. Tags: Miscellanea Source Type: research

COPD and IPF: it's all about regulation and balance
The dominant theory of Hippocrates was that of the four humours—that when the four humours were in balance health prevailed. Therefore, the main goal of the medical therapy was to restore humoral equilibrium. We read with great interest the article by Hou et al,1 where an imbalance between protective and detrimental subgroups of T regulatory (Treg) cells in patients with COPD is showed. On the contrary with previous studies reporting no significant differences in CD4 foxp3+ T cells between patients with COPD and smokers,2 authors performed an elegant series of experiments and dissected Treg cells into three distinct ...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Tzouvelekis, A., Bouros, D. Tags: PostScript Source Type: research

Answer to 'COPD and IPF: it's all about regulation and balance'
We thank Tzouvelekis and Bouros1 for their interest in our recent article in Thorax.2 The theory of Hippocrates reminds us of the balance theory informing traditional Chinese medicine. Ancient Chinese scholars believed there were two natural, complementary yet contradictory forces in our universe: yin and yang, with the former being feminine or negative and the latter masculine or positive. Both of them are always in a state of dynamic balance. A balanced state of yin and yang means health whereas an excess or deficiency of one or the other usually indicates disease. Ancient scholars in China therefore treated this phenome...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Hou, J., Sun, Y., Zeng, H. Tags: PostScript Source Type: research

Defining obesity hypoventilation syndrome
The definition of obesity hypoventilation syndrome (OHS) proposed by Hart et al1 raises two questions that we have tried to answer briefly in this letter. First, previous definitions of OHS included obstructive sleep apnoea (OSA); Hart et al have excluded it. Why? OSA is present in most patients with OHS and is partly responsible for the hypercapnia.2 We believe that it is useful to include it in the definition or classification of the condition in a manner similar to narcolepsy: OHS with OSA and OHS without OSA, as in narcolepsy with cataplexy and narcolepsy without cataplexy. Such classification has mechanistic and thera...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Tulaimat, A., Littleton, S. Tags: PostScript Source Type: research

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)
Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS) is a multicentre observational study of chronic obstructive pulmonary disease (COPD) designed to guide future development of therapies for COPD by providing robust criteria for subclassifying COPD participants into groups most likely to benefit from a given therapy during a clinical trial, and identifying biomarkers/phenotypes that can be used as intermediate outcomes to reliably predict clinical benefit during therapeutic trials. The goal is to enrol 3200 participants in four strata. Participants undergo a baseline visit and three annual follow-up examinat...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Couper, D., LaVange, L. M., Han, M., Barr, R. G., Bleecker, E., Hoffman, E. A., Kanner, R., Kleerup, E., Martinez, F. J., Woodruff, P. G., Rennard, S., for the SPIROMICS Research Group, Alexis, Anderson, Badr, Basta, Boucher, Carretta, Cooper, Curtis, Doe Tags: Therapeutic trials, Epidemiologic studies Chest clinic Source Type: research

DNA copy number changes as diagnostic tools for lung cancer
Lung cancer usually presents as advanced stage disease and there is a need for early diagnosis so that appropriate treatments can be provided prior to tumour progression. Copy number variation is frequently detected in tumours and can contribute to tumour progression. This is because regions harbouring DNA imbalance can contain genes encoding critical proteins whose altered dosage contributes to the neoplastic process. Three copy number variations (CNVs) from chromosomes 3p26-p11.1 (loss), 3q26.2-29 (gain) and 6q25.3-24.3 (loss) have previously been described in individuals presenting with endobronchial squamous metaplasia...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Bowcock, A. M. Tags: Lung neoplasms, Lung cancer (oncology), Lung cancer (respiratory medicine) Chest clinic Source Type: research

COPD, end of life and Ceiling of Treatment
Discussion Death is inevitable. Death is sometimes preventable, but ultimately it is only postponed. This existential truth applies to us all. More immediately, the logic applies to patients with severe COPD just as it does to patients with disseminated malignancy. The only difference between these situations is that... (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Taylor, D. R. Tags: Epidemiologic studies, End of life decisions (geriatric medicine), End of life decisions (palliative care), Hospice, Ethics, Quality improvement Chest clinic Source Type: research

Power injector associated iatrogenic air embolism to the right heart
Air embolism is the entry of air into the vascular system and is usually associated with surgeries, trauma and central lines.1 A patient presented to the clinic with new onset atrial flutter and lower extremity oedema. The patient was admitted and within 24 h, the course became complicated by respiratory failure, requiring intubation and admission to the intensive care unit. A chest CT scan with contrast was ordered for evaluation. Upon acquisition of the images, the patient was found to have at least 50 cc of air to be present in the right atrium and ventricle (figure 1), along with bilateral pulmonary embolism, the ...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Jhamnani, S., Panza, J. A. Tags: Images in Thorax, Journalology, Venous thromboembolism, Pulmonary embolism, Radiology (diagnostics), Ethics Chest clinic Source Type: research

What's hot that the other lot got
Muc5b is in mucus regulation Muc5b is known to be involved in mucus regulation though its specific role is unknown. An American group developed a Muc5b deficient mouse (Nature 505:412–16). Muc5b deficiency caused material to accumulate in the upper airway. This subsequently led to chronic infection by multiple bacterial species including Staphylococcus aureus, with associated impaired resolution of inflammation. There was accumulation of apoptotic macrophages, impaired phagocytosis and a reduction in interleukin 23 production. In mice who had oversecretion of Muc5b, macrophage function improved as did airway clearanc...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Prior, K. Tags: Genetic screening / counselling, Pneumonia (infectious disease), TB and other respiratory infections, Inflammation, Asthma, Pneumonia (respiratory medicine), Radiology (diagnostics) Chest clinic Source Type: research

Obstetric analgesia for vaginal birth in contemporary obstetrics: a survey of the practice of obstetricians in Nigeria
Conclusion: The routine prescription and utilization of obstetric analgesia by obstetricians in Nigeria is still low. Obstetricians are encouraged to step up its use to make childbirth a more fulfilling experience for parturient. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - April 12, 2014 Category: Epidemiology Authors: Lucky O LawaniJustus N EzeOkechukwu B AnozieChukwuemeka A IyokeNduka N Ekem Source Type: research

[Challenges in the context of medical care during a naval research expedition : A case report.]
Abstract Exploration for natural resources in the seabed of the Indian Ocean was undertaken by the German government institution of earth sciences and resources ("Bundesanstalt für Geowissenschaften und Rohstoffe", BGR) in November 2012. To provide for the medical safety of crew and scientists, a cooperation between the BGR and the trauma department of the Hannover Medical School was established. Research by physicians accompanying the naval expedition revealed that medical consultations mainly occur because of respiratory infections, abdominal discomfort, genitourinary discomfort and seasickness, with the rate of...
Source: Der Unfallchirurg - April 12, 2014 Category: Orthopaedics Authors: Schröter C, Schwarz-Schampera U, Mommsen P, Krettek C Tags: Unfallchirurg Source Type: research

A simple breathing circuit allowing precise control of inspiratory gases for experimental respiratory manipulations
Conclusions: We have reported a new approach for the controlled administration of medical gases, and describe an implementation of the breathing circuit that is MRI compatible and uses commercially available parts. The resultant apparatus allows simple, safe and precise manipulations of FiO2 and FiCO2. (Source: BioMed Central)
Source: BioMed Central - April 12, 2014 Category: Journals (General) Authors: Felipe B TancrediIsabelle LajoieRichard D Hoge Source Type: research

A pilot study of respiratory muscle training to improve cough effectiveness and reduce the incidence of pneumonia in acute stroke: study protocol for a randomized controlled trial
This study investigates a novel strategy based on an exercise intervention for cough rehabilitation.Trial registration: Current Controlled Trials ISRCTN40298220 (Source: BioMed Central)
Source: BioMed Central - April 12, 2014 Category: Journals (General) Authors: Stefan Tino KulnikGerrard Francis RaffertySurinder S BirringJohn MoxhamLalit Kalra Source Type: research

Facilitating the transition from physiology to hospital wards through an interdisciplinary case study of septic shock
Conclusions: Horizontal and vertical integration can be presented effectively through a single-session case study, with complex patient cases involving multiple organ systems providing students opportunities to integrate their knowledge across organ systems while emphasizing the importance of physiology in clinical reasoning. Furthermore, having several clinicians from different specialties discuss the case together can reinforce the matter of integration across multiple organ systems and disciplines in students' minds. (Source: BioMed Central)
Source: BioMed Central - April 12, 2014 Category: Journals (General) Authors: Albert S LiKenneth I BergerDavid R SchwartzWilliam R SlaterDavid S Goldfarb Source Type: research

Accuracy evaluation of a numerical simulation model of nasal airflow.
Conclusion: Our numerical simulation model provides an accurate reflection of nasal airflow, and the results were validated by clinical measurements. Objectives: To evaluate the accuracy of a numerical simulation model of nasal airflow. Methods: Ten volunteers with normal nasal cavities underwent CT, acoustic rhinometry, and rhinomanometry. CT data were uploaded into Mimics, ICEM-CFD, Fluent, and CFD-Post software for three-dimensional modeling, finite element grid division, transient calculations, and analysis, respectively. Velocity and pressure data of airflow were obtained during the normal respiratory cycle. The accur...
Source: Acta Oto-Laryngologica - April 11, 2014 Category: ENT & OMF Authors: Lu J, Han D, Zhang L Tags: Acta Otolaryngol Source Type: research

Use of inhaled iloprost in children with pulmonary hypertension
In conclusion, the results of this uncontrolled study showed that iloprost was effective and well tolerated in children. However, further research is needed to support this study, as PH is a serious condition that can require organ transplantation or result in death. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 11, 2014 Category: Respiratory Medicine Authors: Antonio Moreno‐Galdó, Alba Torrent‐Vernetta, Inés de Mir Messa, Sandra Rovira Amigo, Ferran Gran Piña, Silvia Gartner, Dimpna Albert Brotons Tags: Original Article: Other Source Type: research

Assessment of seasonality of influenza in swine using field submissions to a diagnostic laboratory in Ontario between 2007 and 2012
ConclusionsThus, this study identified evidence of seasonality in influenza‐like disease in swine herds, but not in circulation of influenza virus. Evidence of seasonality in exposure to influenza was dependent on assumptions of between‐month correlation. High exposure to H3N2 and H1N1 subtypes warrants more detailed investigation of within‐herd influenza virus circulation. The study provides initial insight into seasonality of influenza in swine and should be followed with herd‐level studies. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - April 11, 2014 Category: Infectious Diseases Authors: Zvonimir Poljak, Susy Carman, Beverly McEwen Tags: Original Article Source Type: research

Eight-year survival of AIDS patients treated with chinese herbal medicine.
Abstract Treatment of acquired immunodeficiency syndrome (AIDS) currently relies on the use of antiretroviral drugs. Little is known about Chinese herbal medicine (CHM) outcomes in patients living with AIDS. We conducted a cohort study to investigate long-term survival among CHM-treated AIDS patients. Patients were poor farmers who contracted HIV-1 infection when selling blood in the 1990s. Symptoms of AIDS included recurring respiratory tract infections with a clinical diagnosis of pneumonia, swollen lymph nodes and weight loss. 385 patients with AIDS were included and 165 of them used a 16-herb formula for 14 day...
Source: The American Journal of Chinese Medicine - April 11, 2014 Category: Complementary Medicine Authors: Zhao HL, Sun CZ, Jiang WP, Dai ZK, Shi WX, Yang KK, Mu XJ, Zhang XX, Sui Y Tags: Am J Chin Med Source Type: research

CR0291 Chédiak-Higashi syndrome: an atypical phenotype case
Chédiak-Higashi syndrome (CHS) is an autosomal recessive disorder usually caused by a mutation in the gene LYST (lysosomal trafficking regulator) resulting in systemic neutrophil abnormalities and characterized by cutaneous, ocular, neurologic, and hematologic abnormalities. CHS usually manifests early in life in the form of partial oculocutaneous albinism (OCA), frequent infections (mostly skin and upper respiratory tract), and lymphadenopathy. Reported oral findings include ulcerations and early-onset periodontitis occurring in childhood. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 11, 2014 Category: ENT & OMF Authors: Christine Nadeau, Muralidhar Mupparapu, Thomas P. Sollecito, Thomas Berardi Tags: Online Only Article Source Type: research

The use of a transcutaneous CO2 monitor during moderate sedation in oral and maxillofacial surgery
Continuous monitoring of end-tidal CO2 (ETCO2) is a requirement for deep sedation and general anesthesia during oral and maxillofacial surgery (OMFS) in 2014, and it may be expanded to moderate sedation in the future. In intubated patients, the ETCO2 measurement usually closely resembles the arterial partial pressure of CO2 (PaCO2). In nonintubated patients undergoing OMFS, ETCO2 measurements are unreliable with respect to the PaCO2, owing to technical limitations in capturing exhaled gases. Transcutaneous CO2 monitors measure the PtCO2 with electrochemical technology independent of expired breaths. This technology closely...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 11, 2014 Category: ENT & OMF Authors: Sanjeet Chaudhary, Ruba Khader, Matthew Finkelman, Daniel Oreadi, Marcin Jarmoc, Roman Schumann, Morton Rosenberg Tags: Online Only Articles Source Type: research

The evaluation of a noninvasive respiratory volume monitor in patients undergoing dental extractions during moderate sedation
This study examined the clinical utility of the ExSpiron Respiratory Volume Monitor (RVM, ExSpiron; Respiratory Motion Inc, Waltham, MA, USA) in patients undergoing oral surgery during moderate sedation. Previous work demonstrated the ability of this novel technology to provide noninvasive, real-time, continuous measurements of respiratory parameters including tidal volume (TV), minute ventilation (MV), and respiratory rate (RR) in spontaneously breathing patients. Current respiratory monitoring in nonintubated patients undergoing oral surgery relies mostly on oximetry, capnography, and subjective clinical assessment. We s...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - April 11, 2014 Category: ENT & OMF Authors: Alireza Ashrafi, Sepideh Sabooree, Maria Papageorge, Morton Rosenberg, Roman Schumann, Archana Viswanath Tags: Online Only Articles Source Type: research

[Virology] A Mouse Model for MERS
Coronavirus (CoV) infections acquired from wild and domesticated animals pose a threat of causing severe and often fatal human pneumonias, as witnessed by the severe acute respiratory – [Read More] (Source: Editors' Choice)
Source: Editors' Choice - April 11, 2014 Category: Science Authors: Caroline Ash Tags: Virology Source Type: research

New sites of localisation of Pasteurella multocida B:2 in buffalo surviving experimental haemorrhagic septicaemia
Conclusions: Commingling naive buffalo calves with calves acutely infected with P. multocida B:2 resulted in carriers among surviving buffalo. Pasteurella was found in various organs of the respiratory, gastrointestinal and urinary tracts, suggesting their role in the pathogenesis of HS. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - April 11, 2014 Category: Veterinary Research Authors: Salleh AnnasMohammad Zamri-SaadFaez JesseZakaria Zunita Source Type: research

Expression of beclin 1 in non‐small cell lung cancer: an inmmunohistochemical study
CONCLUSIONThe results from these experiments indicate that heavy smoking may induce the beclin‐1 protein in NSCLC. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Zhi‐qiang Lv, Jing‐jing Han, Ye‐qing Liu, Li‐li Wang, Qiong‐lan Tang, Qing Sun, Hai‐gang Li Tags: Original Article Source Type: research

Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease
ConclusionsAn imbalance of circulating Th17 cells and Tregs is associated with the deterioration of pulmonary function in patients with moderate and severe COPD. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Huaying Wang, Huajuan Ying, Shi Wang, Xiao Gu, Yuesong Weng, Weidong Peng, Dajing Xia, Wanjun Yu Tags: Original Article Source Type: research

Trefoil factor peptides in serum and sputum from subjects with asthma and COPD
Conclusionsthere is increased secretion of TFF peptides in the lungs of patients with COPD, as well as significant increases in serum levels. This suggests a role for TFF peptides in the pathogenesis of pulmonary diseases with mucus hypersecretion. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Niels‐Erik Viby, Lars Pedersen, Thomas Kromann Lund, Hannelouise Kissow, Vibeke Backer, Ebba Nexø, Lars Thim, Steen Seier Poulsen Tags: Original Article Source Type: research

Physical fitness and amount of asthma and asthma like symptoms from childhood to adulthood
ConclusionThis finding provide further evidence of a possible beneficial effect of physical activity in childhood on the development of respiratory symptoms in adulthood and supports the notion that the lower levels of physical activity in recent decades may have contributed to an increase in the prevalence of asthma and asthma like symptoms. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Jørgen Guldberg–Møller, Bob Hancox, Dennis Mikkelsen, Henrik Steen Hansen, Finn Rasmussen Tags: Original Article Source Type: research

The prognostic value of D‐dimer in lung cancer
ConclusionThe results suggest that determination of D–dimer plasma levels that is an inexpensive, easy and non invasive method may be useful in predicting clinical outcome, survival and treatment response of patients with lung cancer. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Tuba İnal, Ceyda Anar, Gülru Polat, İpek Ünsal, Hüseyin Halilçolar Tags: Original Article Source Type: research

Frequency of Class I and II HLA alleles in patients with lung cancer according to chemotherapy response and five‐year survival
ConclusionOur results suggested that expressions of HLA‐BW6 and HLA‐DRB1*13 alleles may be predictable markers for response to chemotherapy in lung cancer patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Omer Araz, Elif Yilmazel Ucar, Mehmet Meral, Aslıhan Yalcin, Hamit Acemoglu, Hasan Dogan, Adem Karaman, Yener Aydin, Metin Gorguner, Metin Akgun Tags: Original Article Source Type: research

Analysis of pre‐invasive lung adenocarcinoma lesions on thin‐section computerized tomography
ConclusionThe features of thin‐slice CT of AAH and AIS reflected the corresponding morphological changes from AAH progressing to AIS or adenocarcinoma. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 11, 2014 Category: Respiratory Medicine Authors: Xing Yanfen, Li Zhen, Jiang Sen, Xiang Wenjing, Sun Xiwen Tags: Original Article Source Type: research

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation
The increasing manufacture and use of products based on nanotechnology raises concerns for both workers and consumers. Various studies report induction of pulmonary inflammation after inhalation exposure to nanoparticles, which can vary in aspects such as size, shape, charge, crystallinity, chemical composition, and dissolution rate. Each of these aspects can affect their toxicity, although it is largely unknown to what extent. The aim of the current review is to analyse published data on inhalation of nanoparticles to identify and evaluate the contribution of their physicochemical characteristics to the onset and developm...
Source: Particle and Fibre Toxicology - April 11, 2014 Category: Toxicology Authors: Hedwig BraakhuisMargriet ParkIlse GosensWim De JongFlemming Cassee Source Type: research

Epithelial‐mesenchymal transitions in bronchopulmonary dysplasia of newborn rats
ConclusionEMT of AT2 cells occurred in the hyperoxia‐induced newborn rat BPD model and resulted in attenuated alveolar development as a portion of the myofibroblasts accumulated in the lung originated from AT2 cells via EMT. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 11, 2014 Category: Respiratory Medicine Authors: Haiping Yang, Jianhua Fu, Xindong Xue, Li Yao, Lin Qiao, Ana Hou, Linlin Jin, Yujiao Xing Tags: Original Article: Neonatal Lung Disease Source Type: research