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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Occlusive Lung Arterial Lesions in Endothelial-targeted, Fas-Induced Apoptosis (FIA) Transgenic Mice.
Abstract Pulmonary arterial hypertension (PAH) is a lethal disease, characterized by functional and structural abnormalities involving distal pulmonary arterioles that result in increased pulmonary vascular resistance and ultimately right heart failure. In experimental models of pulmonary hypertension, endothelial cell (EC) apoptosis is a necessary trigger for the development of obliterative lung arteriopathy, inducing the emergence of hyperproliferative and apoptosis-resistant vascular cells. However, it has not yet been established whether EC apoptosis is sufficient for the induction of complex lung arteriolar le...
Source: Am J Respir Cell Mol... - April 16, 2015 Category: Respiratory Medicine Authors: Goldthorpe H, Jiang JY, Taha M, Deng Y, Sinclair T, Ge CX, Jurasz P, Turksen K, Mei SH, Stewart DJ Tags: Am J Respir Cell Mol Biol Source Type: research

The relationship between obstructive sleep apnea and hypertension.
Abstract Abstract: There is a bidirectional association between obstructive sleep apnea (OSA) and systemic hypertension. The strengths of this relationship appear to be modulated by factors such as age, sex and somnolence. The 24-hour blood pressure (BP) circadian pattern also appears to be influenced by OSA. Patients with this syndrome exhibit a high prevalence of non-dipping or riser circadian patterns, which are related to clinical and subclinical organ damage in the heart and brain. However, the influence of OSA on nocturnal hypertension development has not yet been clarified. A special area of interest is the ...
Source: Chest - April 16, 2015 Category: Respiratory Medicine Authors: Torres G, Sánchez-de-la-Torre M, Barbé F Tags: Chest Source Type: research

Improved criterion for assessing lung function reversibility.
Conclusions.: We have shown that expressing FEV1BDR as % predicted avoids sex and size bias. FEV1BDR >8% predicted showed optimal survival advantage and may be the most appropriate criterion to define clinically important reversibility. PMID: 25879725 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 16, 2015 Category: Respiratory Medicine Authors: Ward H, Cooper BG, Miller MR Tags: Chest Source Type: research

Severe congenital nemaline myopathy with primary pulmonary lymphangiectasia: unusual clinical presentation and review of the literature
Conclusion: To the best of our knowledge, congenital nemaline myopathy with primary pulmonary lymphangiectasia causing bilateral chylothrax has never been previously reported. Considering chylothorax as a poor prognostic index and an unusual clinical presentation of severe congenital NM are proposed.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9710506431489501. (Source: Diagnostic Pathology)
Source: Diagnostic Pathology - April 16, 2015 Category: Pathology Authors: Jariya WaisayaratChinnawut SuriyonplengsaengChaiyos KhongkhatithumMana Rochanawutanon Source Type: research

Obstructive sleep apnoea and non-restorative sleep induced by the interface.
CONCLUSION: The usage of an oro-nasal mask can result in a paradoxical induction of obstructive hypopnoeas or apnoeas. Clinicians should be aware of this phenomenon. When adapting patients to a PAP therapy, a nasal mask should be preferred even if patients report mouth breathing. PMID: 25877806 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 16, 2015 Category: Sleep Medicine Authors: Westhoff M, Litterst P Tags: Sleep Breath Source Type: research

Endoplasmic Reticulum Stress, Calcium Dysregulation and Altered Protein Translation: Intersection of Processes that Contribute to Cancer Cachexia Induced Skeletal Muscle Wasting.
Abstract Cancer cachexia is a debilitating paraneoplastic wasting syndrome characterized by skeletal muscle depletion and unintentional weight loss. It affects up to 80% of patients with cancer and directly accounts for one-quarter of cancer-related deaths due to cardio-respiratory failure. Muscle weakness, one of the hallmarks of this syndrome, has been postulated to be due to a combination of muscle breakdown, dysfunction and decrease in the ability to repair, with effective treatment strategies presently limited. Excessive inflammatory cytokine levels due to the host-tumor interaction, such as Interleukin (IL)-6...
Source: Current Drug Targets - April 16, 2015 Category: Drugs & Pharmacology Authors: Isaac ST, Tan TC, Polly P Tags: Curr Drug Targets Source Type: research

Pulmonary function abnormalities in adult patients with acute exacerbation of bronchiectasis: A retrospective risk factor analysis.
Abstract Lung function impairments, especially airflow obstruction, are important features during acute exacerbation in patients with bronchiectasis. Recognition of the risk factors associated with airflow obstruction is important in the management of these exacerbations. The medical records of adult patients admitted to the Peking University People's Hospital, Beijing, China, from 2004 to 2011 with a diagnosis of bronchiectasis were reviewed retrospectively. Univariate and multivariate analyses were used to evaluate the risk factors associated with airflow obstruction. Airflow obstruction was found in 55.6% of 156...
Source: Chronic Respiratory Disease - April 16, 2015 Category: Respiratory Medicine Authors: Ma Y, Niu Y, Tian G, Wei J, Gao Z Tags: Chron Respir Dis Source Type: research

Decreasing cost effectiveness of testing for latent TB in HIV in a low TB incidence area.
Abstract Testing for latent tuberculosis infection (LTBI) in HIV-infected persons in low tuberculosis (TB) incidence areas is often recommended. Using contemporary, clinical data, we report the yield and cost-effectiveness of testing all HIV attendees, two current UK strategies and no LTBI testing. Economic modelling was performed utilising 10-year follow up data from a large HIV clinical cohort. Outcomes were numbers of cases of active TB and incremental cost per quality-adjusted life year (QALY) gained. Between 2000 and 2010, 256 people were treated for TB/HIV co-infection. 72 (28%) occurred ⩾3 months after H...
Source: Respiratory Care - April 16, 2015 Category: Respiratory Medicine Authors: Capocci S, Smith C, Morris S, Bhagani S, Cropley I, Abubakar I, Johnson M, Lipman M Tags: Eur Respir J Source Type: research

Statement on smoking cessation in COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit.
We describe the epidemiological links between smoking and pulmonary disorders, the evidence for benefits of stopping smoking, how best to assess tobacco dependence and what interventions currently work best to help pulmonary patients quit. Finally, we describe characteristics and management of any "hardcore" smoker who finds it difficult to quit with standard approaches. PMID: 25882805 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - April 16, 2015 Category: Respiratory Medicine Authors: Jiménez-Ruiz CA, Andreas S, Lewis KE, Tonnesen P, van Schayck CP, Hajek P, Tonstad S, Dautzenberg B, Fletcher M, Masefield S, Powell P, Hering T, Nardini S, Tonia T, Gratziou C Tags: Eur Respir J Source Type: research

Airflow limitation by the Global Lungs Initiative equations in a cohort of very old adults.
Abstract The cut-off for forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) defining airflow limitation for chronic obstructive pulmonary disease (COPD) is still contested. We assessed airflow limitation prevalence by the lower limit of normal (LLN) of Global Lungs Initiative (GLI) 2012 reference values and its predictive ability for all-cause mortality and hospitalisation in very old adults (aged ≥80 years) compared with the fixed cut-off. In a Belgian population-based prospective cohort of 411 very old adults, airflow limitation prevalence by the 5th percentile of GLI 2012 z-scores (GLI-LLN)...
Source: Respiratory Care - April 16, 2015 Category: Respiratory Medicine Authors: Turkeshi E, Vaes B, Andreeva E, Matheï C, Adriaensen W, Van Pottelbergh G, Degryse JM Tags: Eur Respir J Source Type: research

Diagnostic Accuracy of Home-Based Monitoring System in Morbidly Obese Patients with High Risk for Sleep Apnea
Conclusions PM is an efficacious method for diagnosing OSA in obese patients who have a high clinical probability of the disease. The method displays good sensitivity and specificity in severe cases; nevertheless, the high rate of data loss must be taken into account. (Source: Obesity Surgery)
Source: Obesity Surgery - April 15, 2015 Category: Surgery Source Type: research

Joint Annual Meeting of the Schweizerische Gesellschaft für Pneumologie / Société Suisse de Pneumologie. Schweizerische Gesellschaft für Pädiatrische Pneumologie / Société Suisse de Pneumologie Pédiatrique. Schweizerische Gesellschaft für Thoraxchirurgie / Société Suisse de Chirurgie Thoracique. Schweizerische Gesellschaft für Pulmonale Hypertonie / Société Suisse sur l'Hypertension Pulmonaire. 16-17 April 2015, Lugano: Abstracts
Respiration (Source: Respiration)
Source: Respiration - April 15, 2015 Category: Respiratory Medicine Source Type: research

Learning Curve for EBUS-TBNA: Longer than We May Think
Respiration (Source: Respiration)
Source: Respiration - April 15, 2015 Category: Respiratory Medicine Source Type: research

Authors' Reply
Respiration (Source: Respiration)
Source: Respiration - April 15, 2015 Category: Respiratory Medicine Source Type: research

Prediction error and required internal margin provided for irregular respiratory movements: a phantom study
Conclusion The RPM and 4DCT system has a risk of prediction error, which may result from the complicated amplitude irregularity of respiratory movement. (Source: Japanese Journal of Radiology)
Source: Japanese Journal of Radiology - April 15, 2015 Category: Radiology Source Type: research

Strengthening Preventive Cardiology
Non-communicable diseases (NCDs) - mainly cardiovascular diseases (CVD), cancers, chronic respiratory diseases and diabetes are responsible for 63% of global deaths (14 million people annually) and their prevention has been identified as a priority by the World Health Organisation [1]. As a result, the World Health Organisation (WHO) has set a target of a 25% relative reduction in mortality from NCDs by 2025 [1]. Other targets outlined in the WHO Global Action Plan include reductions in risk factors combined with the availability of drug therapy and counselling amongst others (Box) [1]. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - April 15, 2015 Category: Cardiology Authors: Julie Redfern, Clara Chow Tags: Editorial Source Type: research

Discrete Decreased Activity in the Lower Thoracic Spine on FDG PET/CT: Another Respiration-Related Artifact
Conclusion: Error of attenuation correction from respiratory motion can lead to underestimation of FDG activity in the lower thoracic spine, and this should not be interpreted as possible marrow replacement process requiring further imaging if there is coexisting banana artifact. (Source: Clinical Nuclear Medicine)
Source: Clinical Nuclear Medicine - April 15, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Frequency of Obstructive Sleep Apnea Syndrome in Dental Patients with Tooth Wear
Conclusions:Tooth wear could be a tool to identify those patients at risk of having OSAS. This highlights the importance of dental professionals to identify and refer patients with OSAS.Citation:Durán-Cantolla J, Alkhraisat MH, Martínez-Null C, Aguirre JJ, Guinea ER, Anitua E. Frequency of obstructive sleep apnea syndrome in dental patients with tooth wear. J Clin Sleep Med 2015;11(4):445–450. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - April 15, 2015 Category: Sleep Medicine Source Type: research

Vitamin D and respiratory infections
This study aimed to review recent clinical and epidemiological studies conducted in adults and children, and to evaluate the functional role of vitamin D in respiratory infections. The evaluated studies show an important immunomodulatory role of vitamin D, which reduces the incidence and risk of URTIs, both in children and in adults. Combating URTIs can be done prophylactically, associating the use of vaccines against Streptococcus pneumoniae with strengthening the immune system through supplementation with vitamin D. These actions can significantly contribute to reducing the number of URTIs, the use of antibiotics, and co...
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

An outbreak of influenza A(H3N2) in Alappuzha district, Kerala, India, in 2011
Conclusions: An influenza A(H3N2) outbreak was confirmed in Alappuzha district of Kerala state with a co-circulation of A(H1N1)pdm09. No substantial difference in the sequence was observed in the etiological agent, and the virus was found to be sensitive to oseltamivir. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

The clinical characteristics and outcome of children hospitalized with dengue in Barbados, an English Caribbean country
Conclusions: Less than a third of all the children with confirmed dengue required hospitalization. Atypical clinical manifestations were common, and only a minority of these children had severe dengue. Overall, the case fatality rate for dengue in this select population of children hospitalized with dengue was low. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

Vitamin D and respiratory infections
This study aimed to review recent clinical and epidemiological studies conducted in adults and children, and to evaluate the functional role of vitamin D in respiratory infections. The evaluated studies show an important immunomodulatory role of vitamin D, which reduces the incidence and risk of URTIs, both in children and in adults. Combating URTIs can be done prophylactically, associating the use of vaccines against Streptococcus pneumoniae with strengthening the immune system through supplementation with vitamin D. These actions can significantly contribute to reducing the number of URTIs, the use of antibiotics, and co...
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

An outbreak of influenza A(H3N2) in Alappuzha district, Kerala, India, in 2011
Conclusions: An influenza A(H3N2) outbreak was confirmed in Alappuzha district of Kerala state with a co-circulation of A(H1N1)pdm09. No substantial difference in the sequence was observed in the etiological agent, and the virus was found to be sensitive to oseltamivir. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

The clinical characteristics and outcome of children hospitalized with dengue in Barbados, an English Caribbean country
Conclusions: Less than a third of all the children with confirmed dengue required hospitalization. Atypical clinical manifestations were common, and only a minority of these children had severe dengue. Overall, the case fatality rate for dengue in this select population of children hospitalized with dengue was low. (Source: The Journal of Infection in Developing Countries)
Source: The Journal of Infection in Developing Countries - April 15, 2015 Category: Infectious Diseases Source Type: research

$$\dot{V}{\text{O}}_{ 2}$$ V ˙ O 2 kinetics and metabolic contributions during full and upper body extreme swimming intensity
Conclusion Despite the short duration of the event, the aerobic energy contribution covers about 50 % of total metabolic energy liberation, highlighting that both aerobic and anaerobic energy processes should be developed to improve the 100 m swimming performance. Lower limbs action provided an important contribution in the energy availability in working muscles being advised its full use in this short duration and very high-intensity event. (Source: European Journal of Applied Physiology)
Source: European Journal of Applied Physiology - April 15, 2015 Category: Physiology Source Type: research

Needle Gauge and Grey Zone Analysis in Endobronchial Ultrasound-Transbronchial Needle Aspiration: The Need for More Randomised Evidence
Respiration (Source: Respiration)
Source: Respiration - April 15, 2015 Category: Respiratory Medicine Source Type: research

The Epworth Sleepiness Scale in Portuguese adults: from classical measurement theory to Rasch model analysis
Conclusions The ESS showed an adequate structural, internal, and criterion validity, both in the CMT and the RM, suggesting this as a useful and effective measure for assessing sleepiness in Portuguese adults. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

The influence of a clinical classification system on the management of patients with positional dependent obstructive sleep apnoea
(Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Telmisartan attenuates myocardial apoptosis induced by chronic intermittent hypoxia in rats: modulation of nitric oxide metabolism and inflammatory mediators
Conclusions This study show that pre-CIH telmisartan administration ameliorated myocardial injury following CIH by attenuating CIH-induced myocardial apoptosis via regulation of NOS activity and inhibition of excessive NO generation, oxidation/nitration stress, and inflammatory responses. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Positional OSA part 1: towards a clinical classification system for position-dependent obstructive sleep apnoea
We report on the development and process that resulted in the Amsterdam Positional OSA Classification (APOC). Method A panel of three field experts were instructed to independently assign the diagnosis POSA to 100 randomly selected patients they considered likely to benefit from a clinically significant improvement of their OSA with PT. In a group setting, the completed lists were compared. Discrepancies were discussed until consensus was met. This resulted in the consensus standard used to calibrate the new classification. Using the nominal group technique, the APOC was develope...
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Augmentation in restless legs syndrome patients in Korea
Conclusions We found an 11.7 % augmentation rate in Korean RLS subjects. There was no difference in the rate of RLS augmentation between the dopaminergic monotherapy group and the combined treatment group. It may be related with using a similar dosage of dopaminergic drugs. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Trigeminal induced arousals during human sleep
Conclusion Trigeminal stimuli during sleep led to arousals in dose- and time-dependent manner. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Predictors of successful completion of diagnostic home sleep testing in patients with chronic kidney disease
Conclusions Advanced age is an important factor in test refusal and complications of diabetes contributes to test failure. Symptom matching may be a source of selection bias, as patients with risk factors for OSA are more likely to accept the diagnostic test. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Decreased levels of serum nesfatin-1 in patients with obstructive sleep apnea syndrome
Conclusions Decreased serum nesfatin-1 levels are associated with the presence and severity of OSAS. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

A health-economic analysis of diagnosis and treatment of obstructive sleep apnea with continuous positive airway pressure in relation to cardiovascular disease. The Greek experience.
Conclusions CPAP was found to be clinically more effective therapy than no treatment in relation to CVD and a cost-effective strategy in males with severe OSAS. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Effect of chronic continual- and intermittent hypoxia-induced systemic inflammation on the cardiovascular system in rats
Conclusions The current study expands our understanding that both IH and CH could activate the expression of NF-κB and related inflammatory factors as well as cause pathophysiologic damage to the cardiovascular system in OSAS. All these results provide further support to an emerging hypothesis that activation of NF-κB-dependent inflammation may play a central role in the pathophysiology of cardiovascular dysfunction in OSAS. (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Erratum to: Tailored behavioral medicine intervention for enhanced physical activity and healthy eating in patients with obstructive sleep apnea syndrome and overweight
(Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Sleep, mood, and sexual behavior
(Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

Accuracy of a novel auto-CPAP device to evaluate the residual apnea-hypopnea index in patients with obstructive sleep apnea
Conclusions The automatic analysis from auto-CPAP (S9 Autoset) showed a good diagnostic accuracy to identify residual sleep apnea. The absolute agreement between PSG and auto-CPAP to classify the respiratory events correctly varied from very low (obstructive apneas, hypopneas) to moderate (central apneas). (Source: Sleep and Breathing)
Source: Sleep and Breathing - April 15, 2015 Category: Respiratory Medicine Source Type: research

The perception of Obstructive Sleep Apnoea/Hypopnoea Syndrome (OSAHS) among Italian general practitioners
Conclusions: In conclusion, this survey about the perception of OSAHS among GPs in Italy highlighted a satisfactory overall knowledge of OSAHS and only few weak points. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - April 15, 2015 Category: Allergy & Immunology Authors: Carlo LombardiEleonora MusiccoGermano BettoncelliManlio MilaneseGianenrico SennaFulvio BraidoGiorgio Canonica Source Type: research

The Presentation of Respiratory Failure in Elderly Individuals
Abstract Respiratory failure (RF) is a prevalent condition whose presence in elderly patients may be complex and require specific and specialized intervention. A multidimensional evaluation is necessary to choose the best treatment, taking into consideration functional capacity and frailty. Cardiogenic pulmonary edema, community-acquired pneumonia, pulmonary embolism, bronchitis, and acute asthma are the main causes of RF in this patient population. Despite the limited availability of studies and data, including systematic reviews, regarding RF treatment in elderly patients, in this update, we synthesize data to g...
Source: Current Geriatrics Reports - April 15, 2015 Category: Geriatrics Source Type: research

Pulmonary epithelial barrier function: some new players and mechanisms
The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal contents to the subepithelium. In addition, the epithelium dictates the initial responses of the lung to both infectious and noninfectious stimuli. One mechanism by which the epithelium does this is by coordinating transport of diffusible molecules across the epithelial barrier, both through the cell and between cells. In this review, we will discuss a few emerging paradigms of permeability changes through altered ion transport and paracellular regulation by which the epithelium gates its response to potentially detrimental luminal stimu...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2015 Category: Respiratory Medicine Authors: Brune, K., Frank, J., Schwingshackl, A., Finigan, J., Sidhaye, V. K. Tags: REVIEW Source Type: research

Hypoxia-induced proliferation of tissue-resident endothelial progenitor cells in the lung
Exposure to hypoxia induces changes in the structure and functional phenotypes of the cells composing the pulmonary vascular wall from larger to most peripheral vessels. Endothelial progenitor cells (EPCs) may be involved in vascular endothelial repair. Resident EPCs with a high proliferative potential are found in the pulmonary microcirculation. However, their potential location, identification, and functional role have not been clearly established. We investigated whether resident EPCs or bone marrow (BM)-derived EPCs play a major role in hypoxic response of pulmonary vascular endothelial cells (PVECs). Mice were exposed...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2015 Category: Respiratory Medicine Authors: Nishimura, R., Nishiwaki, T., Kawasaki, T., Sekine, A., Suda, R., Urushibara, T., Suzuki, T., Takayanagi, S., Terada, J., Sakao, S., Tatsumi, K. Tags: CALL FOR PAPERS Source Type: research