Respiratory Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.
Computational fluid dynamic study of nasal respiratory function before and after bimaxillary orthognathic surgery with bone trimming at the inferior edge of the pyriform aperture
This study aimed to evaluate the influence of maxillary impaction orthognathic surgery on nasal respiratory function and the efficacy of bone trimming at the inferior edge of the pyriform aperture. (Source: Journal of Oral and Maxillofacial Surgery)
Source: Journal of Oral and Maxillofacial Surgery - June 21, 2016 Category: ENT & OMF Authors: Soma Kita, Marie Oshima, Kazuo Shimazaki, Toshinori Iwai, Susumu Omura, Takashi Ono Source Type: research
Prevalence of Comorbidities in the Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A Systematic Review and Meta-analysis
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - June 21, 2016 Category: Infectious Diseases Authors: Alaa Badawi, Seung Gwan Ryoo Source Type: research
Abdominal massage may decrease gastric residual volumes and abdominal circumference in critically ill patients
Commentary on: Kahraman BB, Ozdemir L. The impact of abdominal massage administered to intubated and enterally fed patients on the development of ventilator-associated pneumonia: a randomized controlled study. Int J Nurs Stud 2015;52:519–24. Implications for practice and research Abdominal massage may decrease gastric residual volumes (GRVs) and abdominal circumference over time in a select medicine critical care unit population. Research and standardisation for the practice of abdominal massage may provide clinicians additional tools for improving overall gastrointestinal (GI) function and feeding in the critically ...
Source: Evidence-Based Nursing - June 21, 2016 Category: Nursing Authors: Warren, M. Tags: Adult nursing, Pneumonia (infectious disease), TB and other respiratory infections, Obesity (nutrition), Pneumonia (respiratory medicine), Health education, Obesity (public health) Source Type: research
Nasal balloon autoinflation can help clear middle ear effusion, improving the quality of life in school-aged children with glue ear
Commentary on: Williamson I, Vennik J, Harnden A, et al.. An open randomised study of autoinflation in 4- to 11-year-old school children with otitis media with effusion in primary care. Health Technol Assess 2015;19:1–150. Implications for practice and research Autoinflation with a nasal balloon can improve symptoms and clear middle ear effusion (MEE) in school-aged children with recent onset of glue ear. Further research is required to determine whether nasal balloon autoinflation reduces the need for grommet surgery. Context Otitis media with effusion, commonly known as glue ear, is the most common cause of hearing...
Source: Evidence-Based Nursing - June 21, 2016 Category: Nursing Authors: Schilder, A. G. M., Venekamp, R. P. Tags: Health policy, General practice / family medicine, Child health, Immunology (including allergy), Otitis, TB and other respiratory infections, Pain (neurology), Child health, Ear, nose and throat/otolaryngology, Health service research Source Type: research
Confirming nasogastric tube placement: Is the colorimeter as sensitive and specific as X-ray? A diagnostic accuracy study
The effect of delivering enteral nutrition or medications via a nasogastric tube that is inadvertently located in the tracheobronchial tract can cause respiratory complications. Although radiographic examination is accepted as the gold standard for confirming the position of patients’ enteral tubes, it is costly, involves risks of radiation, and is not failsafe. Studies using carbon dioxide sensors to detect inadvertent nasogastric tube placements have been conducted in intensive care settings. However, none involved patients in general wards. (Source: International Journal of Nursing Studies)
Source: International Journal of Nursing Studies - June 21, 2016 Category: Nursing Authors: Siti Zubaidah Mordiffi, Mien Li Goh, Jason Phua, Yiong-Huak Chan Source Type: research
Individualized lung recruitment during high-frequency ventilation in preterm infants is not associated with lung hyperinflation and air leaks
Conclusion: The risk of significant hyperinflation and air leaks is low when using an individualized oxygenation-guided recruitment procedure during HFV in preterm infants with RDS. What is Known: • Lung recruitment during high-frequency ventilation in preterm infants with respiratory distress syndrome is associated with an increased risk of lung hyperinflation and air leaks. What is New: ...
Source: European Journal of Pediatrics - June 21, 2016 Category: Pediatrics Source Type: research
Bone health and disease in cystic fibrosis
Low bone mineral density is common in children and adults with CF. It has a multifactorial aetiology that includes direct effects of CFTR dysfunction on bone cell activity, as well as the secondary effects of CFTR dysfunction including pancreatic insufficiency (leading to malnutrition/malabsorption of fat soluble vitamins) and pulmonary infection (leading to systemic inflammation and increased bone resorption). Strategies to improve bone health in CF include optimising general CF nutritional and pulmonary care and the judicious use of bisphosphonates in selected patients. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - June 21, 2016 Category: Respiratory Medicine Authors: Malcolm Marquette, Charles S. Haworth Source Type: research
Relationships between emphysema and airways metrics at high-resolution computed tomography (HRCT) and ventilatory response to exercise in mild to moderate COPD patients
In Chronic Obstructive Pulmonary Disease (COPD) patients, the opportunity to carry out a thoracic high-resolution CT (HRCT) scan and to perform an incremental cardiopulmonary exercise test (CPET) increases the possibility to identify the different clinical features of disease. The aim of our study was to evaluate the relationships between HRCT metrics (on emphysema by low attenuation areas-LAA% and airways by wall area-WA%) and CPET variables related to the dynamic response to exercise in terms of elastic balance (Δ rest-to-peak IC/TLC) and ventilation capacity for carbon dioxide output (VE/VCO2 slope and VE/VCO2 intercep...
Source: Respiratory Medicine CME - June 21, 2016 Category: Respiratory Medicine Authors: Ernesto Crisafulli, Veronica Alfieri, Mario Silva, Marina Aiello, Panagiota Tzani, Gianluca Milanese, Giuseppina Bertorelli, Nicola Sverzellati, Alfredo Chetta Source Type: research
A novel guluronate oligomer improves intestinal transit and survival in cystic fibrosis mice
Cystic fibrosis (CF) patients experience intestinal complications characterized by the accumulation of thick viscous mucus. CF mice were utilized to determine if a novel guluronate oligomer, OligoG, may be a potential therapy in reducing intestinal mucus and subsequent CF-related intestinal manifestations. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 21, 2016 Category: Respiratory Medicine Authors: Megan Vitko, Dana M. Valerio, Philip D. Rye, Edvar Onsøyen, Astrid H. Myrset, Arne Dessen, Mitchell L. Drumm, Craig A. Hodges Tags: Original Article Source Type: research
Objective airway artery dimensions compared to CT scoring methods assessing structural cystic fibrosis lung disease
CF-CT and PRAGMA-CF are commonly used scoring methods to quantify the severity of bronchiectasis (BE) and airway wall thickening (AWT) on chest CTs of children with cystic fibrosis (CF). We aimed to validate CF-CT and PRAGMA-CF sub-scores for BE and AWT against quantitative airway–artery (AA) dimensions. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 21, 2016 Category: Respiratory Medicine Authors: Wieying Kuo, Eleni-Rosalina Andrinopoulou, Adria Perez-Rovira, Hadiye Ozturk, Marleen de Bruijne, Harm H.A.W.M. Tiddens Tags: Original Article Source Type: research
[Hidden allergens in processed food : An update from the consumer's point of view].
Abstract Despite improved allergen labelling and careful avoidance strategies, hidden allergens in food remain a substantial risk for unintended reactions for consumers with food allergies. New data from a survey of the German Allergy and Asthma Association (Deutscher Allergie- und Asthmabund - DAAB) shows a slight decrease in the number of consumers that report allergic reactions to prepacked food. Still, 75 % (compared to 85 % in 2008) have experienced at least one allergic reaction after eating a prepacked food. In more than half of the cases, the reaction was classified as severe (with airway and/or car...
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - June 21, 2016 Category: Global & Universal Authors: Schnadt S, Pfaff S Tags: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz Source Type: research
Comparing Use of Low-Value Health Care Services Among U.S. Advanced Practice Clinicians and Physicians.
Conclusion: APCs and physicians provided an equivalent amount of low-value health services, dispelling physicians' perceptions that APCs provide lower-value care than physicians for these common conditions. Primary Funding Source: U.S. Health Services and Research Administration, Ryoichi Sasakawa Fellowship Fund, and National Institutes of Health. PMID: 27322541 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - June 21, 2016 Category: Internal Medicine Authors: Mafi JN, Wee CC, Davis RB, Landon BE Tags: Ann Intern Med Source Type: research
Corneal toxicity induced by vesicating agents and effective treatment options
The vesicating agents sulfur mustard (SM) and lewisite (LEW) are potent chemical warfare agents that primarily cause damage to the ocular, skin, and respiratory systems. However, ocular tissue is the most sensitive organ, and vesicant exposure results in a biphasic injury response, including photophobia, corneal lesions, corneal edema, ulceration, and neovascularization, and may cause loss of vision. There are several reports on ocular injury from exposure to SM, which has been frequently used in warfare. However, there are very few reports on ocular injury by LEW, which indicate that injury symptoms appear instantly after...
Source: Annals of the New York Academy of Sciences - June 21, 2016 Category: Science Authors: Dinesh G. Goswami, Neera Tewari‐Singh, Rajesh Agarwal Tags: Original Article Source Type: research
Cd(2+) extrusion by P-type Cd(2+)-ATPase of Staphylococcus aureus 17810R via energy-dependent Cd(2+)/H(+) exchange mechanism.
Abstract Cd(2+) is highly toxic to Staphylococcus aureus since it blocks dithiols in cytoplasmic 2-oxoglutarate dehydrogenase complex (ODHC) participating in energy conservation process. However, S. aureus 17810R is Cd(2+)-resistant due to possession of cadA-coded Cd(2+) efflux system, recognized here as P-type Cd(2+)-ATPase. This Cd(2+) pump utilizing cellular energy-ATP, ∆μ H (+) (electrochemical proton potential) and respiratory protons, extrudes Cd(2+) from cytoplasm to protect dithiols in ODHC, but the mechanism of Cd(2+) extrusion remains unknown. Here we propose that two Cd(2+) taken up by strain 17810R v...
Source: Biometals - June 21, 2016 Category: Biochemistry Authors: Tynecka Z, Malm A, Goś-Szcześniak Z Tags: Biometals Source Type: research
Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction.
Abstract The loss of strength in combination with constant fatigue is a burden on cancer patients undergoing chemotherapy. Doxorubicin, a standard chemotherapy drug used in the clinic, causes skeletal muscle dysfunction and increases mitochondrial H2O2 We hypothesized the combined effect of cancer and chemotherapy in an immunocompetent breast cancer mouse model (E0771) would compromise skeletal muscle mitochondrial respiratory function, leading to an increase in H2O2 emitting potential and impaired muscle function. Here we demonstrate cancer chemotherapy decreases mitochondrial respiratory capacity supported with c...
Source: Am J Physiol Endocri... - June 21, 2016 Category: Endocrinology Authors: Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD Tags: Am J Physiol Endocrinol Metab Source Type: research
Long-term non-invasive ventilation in muscular dystrophy: Trends in use over 25 years in a home ventilation unit.
Abstract Long-term non-invasive ventilation (NIV) was introduced in the 1980s, initially mainly for patients with poliomyelitis, muscular dystrophy (MD) or scoliosis. The obesity-hypoventilation syndrome has since become the commonest reason for referral to most centres providing home-NIV. Patients with MD are numerically a much smaller part of the workload, but as their disease progresses the need for ventilatory support changes and they require regular comprehensive assessment of their condition. We have examined the trend in MD use of home-NIVin our unit over the last 25 years. The number of new referrals appear...
Source: Chronic Respiratory Disease - June 21, 2016 Category: Respiratory Medicine Authors: Kinnear W, Colt J, Watson L, Smith P, Johnson L, Burrows S, Sovani M, Khanna A, Maddison P, Wills A Tags: Chron Respir Dis Source Type: research
With the strength to carry on: The role of sense of coherence and resilience for anxiety, depression and disability in chronic obstructive pulmonary disease.
This study's results indicated that SOC and resilience could represent helpful individual resources due to their protective potential helping people adjust to COPD. Limitations and implications of this study are discussed. PMID: 27330036 [PubMed - as supplied by publisher] (Source: Chronic Respiratory Disease)
Source: Chronic Respiratory Disease - June 21, 2016 Category: Respiratory Medicine Authors: Keil DC, Vaske I, Kenn K, Rief W, Stenzel NM Tags: Chron Respir Dis Source Type: research
Exploring self-conscious emotions in individuals with chronic obstructive pulmonary disease: A mixed-methods study.
This study aimed to explore the extent to which self-conscious emotions are expressed, to explore any associations with adverse health outcomes, and to compare self-conscious emotions in individuals with chronic obstructive pulmonary disease (COPD) to healthy controls. A two-stage mixed-methods study design was employed. Interviews with 15 individuals with COPD informed the choice of questionnaires to assess self-conscious emotions which were completed by individuals with COPD and healthy controls. Five overarching themes were abstracted: grief, spectrum of blame, concern about the view of others, concealment, and worry ab...
Source: Chronic Respiratory Disease - June 21, 2016 Category: Respiratory Medicine Authors: Harrison SL, Robertson N, Goldstein RS, Brooks D Tags: Chron Respir Dis Source Type: research
Lutimaribacter marinistellae sp. nov., isolated from a starfish of China.
Abstract A taxonomic study was carried out on a Gram staining negative bacterium, namely strain SF-12T, isolated from an unidentified starfish living in Sanya, China. Cells of strain SF-12T were non-spore-forming rods, 0.5-0.8 μm wide, 2.2-2.5 μm long, and motile by flagella. Strain SF-12T was facultatively anaerobic, heterotrophic, oxidase- and catalase-positive. Growth of strain SF-12T occurred at 15-38 oC (optimum, 30 oC), at pH 6.5-8.5 (optimum, pH 7.0), and in the presence of 2.0-7.0% (w/v) NaCl (optimum, 3.0-4.0 %). The predominant fatty acids of strain SF-12T were C18:1ω7c and/or C18:1ω6c. Ubiquinone 10 ...
Source: International Journal of Systematic and Evolutionary Microbiology - June 21, 2016 Category: Microbiology Authors: Zhang Y, Tang P, Xu Y, Fang W, Wang X, Fang Z, Xiao Y Tags: Int J Syst Evol Microbiol Source Type: research
Massilia pinisoli sp. nov., isolated from forest soil in Korea.
Abstract A Gram-stain-negative, aerobic, motile with a single polar flagellum, non-spore-forming and rod-shaped bacterial strain named T33T was isolated from forest soil collected at Kyonggi University, South Korea. The strain was catalase- and oxidase-positive, colonies grown on R2A agar at 32°C. Sequencing of the 16S rRNA gene and phylogenetic analysis revealed that T33T belongs to the genus Massilia and is closely related to Massilia niastensis KACC 12599T (98.7% sequence similarity), Massilia aerilata KACC 12505T (98.5%), Massilia tieshanensis KACC 14940T (98.4%), Massilia kyonggiensis KACC 17471T (98.1%), Mas...
Source: International Journal of Systematic and Evolutionary Microbiology - June 21, 2016 Category: Microbiology Authors: Altankhuu K, Kim J Tags: Int J Syst Evol Microbiol Source Type: research
Development of a simple screening tool for opportunistic COPD case finding in primary care in Latin America: The PUMA study
ConclusionThis simple seven‐item score is an accurate screening tool to select subjects for spirometry in primary care. (Source: Respirology)
Source: Respirology - June 20, 2016 Category: Respiratory Medicine Authors: Maria Victorina López Varela, Maria Montes de Oca, Alejandra Rey, Alejandro Casas, Roberto Stirbulov, Valentina Di Boscio, Tags: Original Article Source Type: research
Gastric mucormycosis: Diagnosis by imprint cytology
We report a case of gastric mucormycosis in an immmunocompetent male patient, diagnosed by imprint cytology—a rare site and a rare setting. To the best of our knowledge, this is only the second report of gastric mucormycosis being diagnosed on cytology. As the disease is rapidly progressive and often fatal, early diagnosis is critical to the patient survival. Imprint cytology or brush cytology is extremely useful for the rapid diagnosis of gastric mucormycosis as these organisms are morphologically distinct. Familiarity with the cytomorphology of these organisms assists in the correct diagnosis of this disease. Diagn. Cy...
Source: Diagnostic Cytopathology - June 20, 2016 Category: Pathology Authors: Shilpa P. Tathe, Aarti A. Dani, Sanjay M. Chawhan, Saroj A. Meshram, Archana A. Randale, Waman K. Raut Tags: Brief Report Source Type: research
Changes of 2015 WHO Histological Classification of Lung Cancer
and the Clinical Significance
Due in part to remarkable advances over the past decade in our understanding of lung cancer, particularly in area of medical oncology, molecular biology, and radiology, there is a pressing need for a revised classification, based not on pathology alone, but rather on an integrated multidisciplinary approach to classification of lung cancer. The 2015 World Health Organization (WHO) Classification of Tumors of the Lung, Pleura, Thymus and Heart has just been published with numerous important changes from the 2004 WHO classification. The revised classification has been greatly improved in helping advance the field, increasing...
Source: Chinese Journal of Lung Cancer - June 20, 2016 Category: Cancer & Oncology Source Type: research
Need for intensive care in patients admitted for asthma: Red flags from the social history
ConclusionAmong patients admitted to hospital for asthma, illicit substance abuse is a strong independent risk factor for intensive care requirement. Preventer therapy nonadherence further increases this risk. Lower socioeconomic status is also associated with increased risk. These historical features should be actively sought on admission and may serve as useful ‘red flags’ to prompt consideration of intensive monitoring. (Source: Respirology)
Source: Respirology - June 20, 2016 Category: Respiratory Medicine Authors: Fiona Moghaddas, Catherine Smith, David Pilcher, Robyn O'Hehir, Mark Hew, Eli Dabscheck Tags: Original Article Source Type: research
Phenotypic Destiny in Mitochondrial Disease?
Mitochondrial diseases are a group of heterogeneous disorders caused by inherited mutations in the mitochondrial genome (mtDNA) and nuclear genome. Typically, mutations in the mtDNA are maternally inherited and cause respiratory chain defects and account for a substantial fraction of childhood and adult neurometabolic disease, with an estimated prevalence of 1:5000 (0.02%). The most common mtDNA mutation is the mitochondrial 3243A>G mutation (m.3243A>G) in the MTTL1 gene (OMIM 590050), which encodes the transfer RNA tRNALeu(UUR). This mutation is associated with multiple clinical and psychiatric manifestations, including d...
Source: JAMA Neurology - June 20, 2016 Category: Neurology Source Type: research
Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases in the world and genetic selection of pigs for increased resistance to PRRS is an attractive method to improve t... (Source: Genetics Selection Evolution)
Source: Genetics Selection Evolution - June 20, 2016 Category: Genetics & Stem Cells Authors: Andrew S. Hess, Zeenath Islam, Melanie K. Hess, Raymond R. R. Rowland, Joan K. Lunney, Andrea Doeschl-Wilson, Graham S. Plastow and Jack C. M. Dekkers Source Type: research
Middle East respiratory syndrome coronavirus on inanimate surfaces: A risk for health care transmission
Publication date: Available online 20 June 2016 Source:American Journal of Infection Control Author(s): Raymond M. Khan, Hasan M. Al-Dorzi, Sameera Al Johani, Hanan H. Balkhy, Thamer H. Alenazi, Salim Baharoon, Yaseen M. Arabi The Middle East Respiratory syndrome coronavirus (MERS-CoV) has been responsible for multiple health care–associated outbreaks. We investigated whether high-touch surfaces in 3 rooms of laboratory-confirmed MERS-CoV patients were contaminated with MERS-CoV RNA. We found 2 out of 51 surfaces were contaminated with MERS-CoV viral genetic material. Hence, environmental contamination may be a ...
Source: American Journal of Infection Control - June 20, 2016 Category: Infectious Diseases Source Type: research
Sleep Disturbance in Caregivers of Children With Respiratory and Atopic Disease
Conclusions Deficient and poor-quality sleep in caregivers of children with chronic illness may have a significant impact on their health and well-being, as well as caregiving responsibilities. These data provide important information for pediatric psychologists working with these families. (Source: Journal of Pediatric Psychology)
Source: Journal of Pediatric Psychology - June 20, 2016 Category: Pediatrics Authors: Meltzer, L. J., Booster, G. D. Tags: Regular Articles Source Type: research
Pleural Lipoma Presenting With Back Pain
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - June 20, 2016 Category: Respiratory Medicine Authors: Tayfun Kermenli, Ahmet Cemal Pazarlı, Emre Akarsu, Timur Ekiz Tags: Letter to the Editor Source Type: research
Postoperative acute respiratory failure caused by adult‐onset Pompe disease
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - June 20, 2016 Category: Respiratory Medicine Authors: Dingyu Tan, Jun Xu, Yi Yang, Ming Gu, Xuezhong Yu Tags: Case Report Source Type: research
Evaluation of the rapid immunochromatographic ODK0501 assay for Streptococcus pneumoniae antigen detection with nasopharyngeal swabs: preliminary report
Conclusion RAPIRUN performed with nasopharyngeal swabs from adult patients exhibited lower sensitivity for the diagnosis of pneumococcal pneumonia than the other compared methods. The causative pathogen of pneumonia should be identified using not only sputum cultures or rapid antigen detection kits but also clinical features or gram staining of sputum. (Source: Multidisciplinary Respiratory Medicine)
Source: Multidisciplinary Respiratory Medicine - June 20, 2016 Category: Respiratory Medicine Source Type: research
Long-term follow-up after implantation of the Shelhigh(R) No-React(R) complete biological aortic valved conduit [ADULT CARDIAC]
CONCLUSIONS The Shelhigh® No-React® aortic valved conduit showed satisfactory short-term operative results. However, the long-term follow-up revealed a relatively high rate of deaths, which may be explained by the epidemiology of the patient group, but a substantial proportion of deaths could not be clarified. The overall rate of reoperation (8.6%) during the mid-term follow-up is worrisome and the failures due to aortoventricular disconnection, endocarditis and pseudoaneurysm formation remain unexplained. The redo-procedures were technically demanding. We recommend close follow-up of patients with the Shelhigh®...
Source: European Journal of Cardio-Thoracic Surgery - June 20, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Reineke, D. C., Kaya, A., Heinisch, P. P., Oezdemir, B., Winkler, B., Huber, C., Heijmen, R. H., Morshuis, W., Carrel, T. P., Englberger, L. Tags: Basic research vascular ADULT CARDIAC Source Type: research
Differences in Virulence Between Bovine-Derived Clinical Isolates of Pasteurella multocida Serotype A from the UK and the USA in a Model of Bovine Pneumonic Pasteurellosis
Publication date: Available online 20 June 2016 Source:Journal of Comparative Pathology Author(s): M.P. Dagleish, C.W. Bayne, G.G. Moon, J. Finlayson, J. Sales, J. Williams, J.C. Hodgson The time of onset and subsequent degree and progression of clinical signs, bacterial colonization and tissue pathology during experimental disease induced by intratracheal inoculation of either a UK or USA isolate of Pasteurella multocida serotype A recovered from clinical cases of bovine pneumonia were determined. Calves aged 8 weeks were challenged with 300 ml phosphate buffered saline (PBS) alone (group 1, n = 3, negative co...
Source: Journal of Comparative Pathology - June 20, 2016 Category: Pathology Source Type: research
Effects of positive end expiratory pressure administration during non‐invasive ventilation in patients affected by amyotrophic lateral sclerosis: A randomized crossover study
ConclusionIn ALS patients, PEEP application during NIV was associated with worse NIV and sleep quality and with higher sympathetic activity. (Source: Respirology)
Source: Respirology - June 20, 2016 Category: Respiratory Medicine Authors: Grazia Crescimanno, Francesca Greco, Salvo Arrisicato, Noemi Morana, Oreste Marrone Tags: Original Article Source Type: research
Factors associated with abnormal pulmonary function test among subjects with normal chest radiography: The Korean National Health and Nutrition Examination Survey
Determinants of abnormal lung function among subjects with normal chest radiography have not been widely evaluated. We investigated 12 109 participants with normal chest radiographs from the Korean National Health and Nutrition Examination Survey. Factors associated with abnormal pulmonary function were male gender, age ≥50, smoking history and a clinical history of cough or sputum production. Pulmonary function tests should be considered in population‐based screening, especially in men over 50 years old with a smoking history. (Source: Respirology)
Source: Respirology - June 20, 2016 Category: Respiratory Medicine Authors: Kum Ju Chae, Keun‐Sang Kwon, Gong Yong Jin, Heejung Bang, Juhyung Lee Tags: Scientific Letter Source Type: research
Short-Term Variation of Lung Function and Airway Inflammation in Children and Adolescents with Bronchiolitis Obliterans
Conclusions The short-term variability of sputum neutrophilia and lung function is low in BO patients. This finding should be considered to identify successful treatment in the individual patient and could be used as endpoints for future BO-related studies. (Source: Lung)
Source: Lung - June 20, 2016 Category: Respiratory Medicine Source Type: research
A 47‐year‐old woman with hypercapnia and altered mental status
Abstract Permissive hypercapnia is a commonly used ventilator strategy in attempt to improve refractory hypoxemia. The rationale of such practice is based on the assumption that hypercapnia, although associated with altered mental status, is well tolerated. Here, we report a case in which the altered mental status caused by hypercapnia is underlined by a life‐threatening mechanism. The case indicates the severity of hypercapnia may have been mistakenly overlooked in the past. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - June 20, 2016 Category: Respiratory Medicine Authors: Brian Bellucci, Renli Qiao Tags: CASE REPORT Source Type: research
Near‐peer teaching programme for medical students
We describe a student‐as‐teacher programme developed for fourth‐year students (MS4s) helping to deliver the second‐year Respiratory Pathophysiology course at our medical school. MethodsTwelve MS4s were paired with faculty members to co‐teach one or two small group case‐based sessions for second‐year students (MS2s). Beforehand, MS4s attended an orientation session and workshop, reviewing skills and strategies for teaching effectively. Following each teaching session co‐taught by MS4s, both MS4s and MS2s completed multiple‐choice surveys evaluating the MS4's teaching skills and the experience overall. MS4s...
Source: The Clinical Teacher - June 20, 2016 Category: Universities & Medical Training Authors: Zoe Gottlieb, Samantha Epstein, Jeremy Richards Tags: Original Article Source Type: research
Measuring the individual benefit of a medical or behavioral treatment using generalized linear mixed‐effects models
We propose statistical definitions of the individual benefit of a medical or behavioral treatment and of the severity of a chronic illness. These definitions are used to develop a graphical method that can be used by statisticians and clinicians in the data analysis of clinical trials from the perspective of personalized medicine. The method focuses on assessing and comparing individual effects of treatments rather than average effects and can be used with continuous and discrete responses, including dichotomous and count responses. The method is based on new developments in generalized linear mixed‐effects models, which...
Source: Statistics in Medicine - June 20, 2016 Category: Statistics Authors: Francisco J. Diaz Tags: Research Article Source Type: research
X-linked Hyper IgM Syndrome Presenting as Pulmonary Alveolar Proteinosis
Conclusions The clinical manifestations of XHIGM in our patient had several unique features, including the presentation with PAP, normal serum IgA, and expression of non-functional CD40L on activated T cells. To our knowledge, this is the first published case of PAP in a patient with XHIGM. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - June 20, 2016 Category: Allergy & Immunology Source Type: research
Efficacy, Safety, and Pharmacokinetics of a New 10 % Liquid Intravenous Immunoglobulin Containing High Titer Neutralizing Antibody to RSV and Other Respiratory Viruses in Subjects with Primary Immunodeficiency Disease
Conclusions There were zero serious bacterial infections, thus meeting the primary endpoint for this trial. The secondary endpoints including days missed from work due to infection, unscheduled visits to the physician, and days of hospitalization due to infection compared favorably to published reports of other IVIG products. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - June 20, 2016 Category: Allergy & Immunology Source Type: research