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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Pneumonia and influenza, and respiratory and circulatory hospital admissions in Belgium: a retrospective database study
Conclusion: The clinical and economic burden of primary influenza hospitalizations in Belgium is substantial. The elderly patient group together with children aged (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 14, 2014 Category: Epidemiology Authors: Ralph CrottIsabelle PouplierIsabelle RochYi-Chen ChenMarie-Christine Closon Source Type: research

Early risk factors for pubertal asthma
Conclusion and clinical relevanceImportant early risk factor for pubertal asthma were early airways obstruction, parental rhinitis, being the first born child and perinatal familial stress.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - September 14, 2014 Category: Allergy & Immunology Authors: Vegard Hovland, Amund. Riiser, Petter Mowinckel, Kai‐ Håkon Carlsen, Karin C Lødrup Carlsen Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research

Atopy and cause‐specific mortality
Conclusions & Clinical RelevanceWe found no statistically significant association between atopy and all‐cause mortality. However, atopy was associated with a significantly higher risk of dying from mental and behavioural disorders and gastrointestinal diseases, particularly liver diseases, and a lower risk of dying from breast cancer, but these associations were not statistically significant when applying the Bonferroni adjusted significance level. Further studies are needed to confirm our findings.This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - September 14, 2014 Category: Allergy & Immunology Authors: Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbæk Thuesen, Lene Hammer‐Helmich, Allan Linneberg Tags: Original Article‐Epidemiology of Allergic Disease Source Type: research

Differential injurious effects of ambient and traffic‐derived particulate matter on airway epithelial cells
ConclusionsAmbient PM10 is likely to be more important than traffic‐derived PM in causing injury to AEC leading to production of pro‐inflammatory cytokines. The injurious effects may be related to the presence of iron in the coarse fraction of airborne PM. These findings are likely to be relevant to the pathogenesis of asthma. (Source: Respirology)
Source: Respirology - September 14, 2014 Category: Respiratory Medicine Authors: Rakesh K. Kumar, Alexander M. Shadie, Martin P. Bucknall, Helen Rutlidge, Linda Garthwaite, Cristan Herbert, Brendan Halliburton, Kristy S. Parsons, Peter A.B. Wark Tags: Original Article Source Type: research

Relationships between ventilatory impairment, sleep hypoventilation and type 2 respiratory failure
Abstract Conditions that increase load on respiratory muscles and/or reduce their capacity to cope with this load predispose to type 2 (hypercapnic) respiratory failure. In its milder forms, this imbalance between load and capacity may primarily manifest as sleep hypoventilation which, if untreated, can increase the likelihood of wakeful respiratory failure. Such problems are commonly seen in progressive respiratory neuromuscular disorders, morbid obesity and chronic obstructive pulmonary disease, either separately or together. Identifying patients at risk can be important in determining whether and when to intervene with ...
Source: Respirology - September 14, 2014 Category: Respiratory Medicine Authors: David Hillman, Bhajan Singh, Nigel McArdle, Peter Eastwood Tags: Invited Review Series: Respiratory Disease: Using Lung Function Measurements to Greater Advantage Source Type: research

Impact of anxiety and depression on respiratory symptoms
This study included 2270 subjects aged 20–44 (52% female) from Sweden, Iceland, and Norway. Each participant underwent a clinical interview including questions on respiratory symptoms. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - September 14, 2014 Category: Respiratory Medicine Authors: Mai Leander, Erik Lampa, Anna Rask-Andersen, Karl Franklin, Thorarinn Gislason, Anna Oudin, Cecilie Svanes, Kjell Torén, Christer Janson Source Type: research

Severity and outcomes of community acquired pneumonia in asthmatic patients
Limited information is available about clinical outcomes and microbiology of community-acquired pneumonia in asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - September 14, 2014 Category: Respiratory Medicine Authors: Silvia Terraneo, Eva Polverino, Catia Cilloniz, Rosanel Amaro, Mª del Carmen Vennera, Albert Gabarrus, Beatriz Montull, Encarnación Moreno, Rosario Menendez, Stefano Centanni, Antoni Torres Source Type: research

Atopy and cause-specific mortality.
CONCLUSIONS & CLINICAL RELEVANCE: We found no statistically significant association between atopy and all-cause mortality. However, atopy was associated with a significantly higher risk of dying from mental and behavioural disorders and gastrointestinal diseases, particularly liver diseases, and a lower risk of dying from breast cancer, but these associations were not statistically significant when applying the Bonferroni adjusted significance level. Further studies are needed to confirm our findings. This article is protected by copyright. All rights reserved. PMID: 25220375 [PubMed - as supplied by publisher] (So...
Source: Clinical Genitourinary Cancer - September 14, 2014 Category: Cancer & Oncology Authors: Skaaby T, Husemoen LL, Thuesen BH, Hammer-Helmich L, Linneberg A Tags: Clin Exp Allergy Source Type: research

MPT64 polymorphisms of strains suggest ongoing immune evasion
In our previous study, we found that polymorphisms of the mpt64 gene in the Mycobacterium tuberculosis complex (MTBC) may be the reason for changes in the antigen produced, which may in turn cause alterations of related functions. Based on the data, we further analyzed T/B cell epitope regions and non-epitope regions and compared amino acid changes between them. It turned out the polymorphisms of MPT64 affected both T cell epitopes and B cell epitopes, which thus influenced cell-mediated immunity and humoral immunity at the same time. (Source: Tuberculosis)
Source: Tuberculosis - September 14, 2014 Category: Respiratory Medicine Authors: Yi Jiang, Haican Liu, Kanglin Wan Source Type: research

Case of inappropriate ADH syndrome: Hyponatremia due to polyethylene glycol bowel preparation.
Abstract Colonoscopic screening has been reported to reduce deaths from colorectal cancer. Adequate bowel preparation is essential for this and safety is an important issue in choosing the methods. Polyethylene glycol (PEG) is regarded as a safe method for cleansing, especially compared with oral sodium phosphate. Here, we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone (ADH) syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures. A 62-year-old women had ingested PEG for precolonoscopic bowel cleansing. While waiting for the colonoscop...
Source: World Journal of Gastroenterology : WJG - September 14, 2014 Category: Gastroenterology Authors: Ko SH, Lim CH, Kim JY, Kang SH, Baeg MK, Oh HJ Tags: World J Gastroenterol Source Type: research

Blue code: Is it a real emergency?
CONCLUSION: The findings of this study show that more research is needed to establish the overall effectiveness and optimal implementation of blue code teams. PMID: 25215142 [PubMed] (Source: Pain Physician)
Source: Pain Physician - September 13, 2014 Category: Anesthesiology Authors: Eroglu SE, Onur O, Urgan O, Denizbasi A, Akoglu H Tags: World J Emerg Med Source Type: research

Upper Airway Obstruction during Noninvasive Ventilation Induced by the Use of an Oronasal Mask
We report a case indicating another cause of upper airway obstruction: use of an oronasal mask can induce obstructive events in the upper airways, possibly resulting in sleep fragmentation and decreased efficiency of NIV.Citation:Vrijsen B, Buyse B, Belge C, Testelmans D. Upper airway obstruction during noninvasive ventilation induced by the use of an oronasal mask. J Clin Sleep Med 2014;10(9):1033-1035. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - September 13, 2014 Category: Sleep Medicine Source Type: research

Risk factors of recurrence for resected T1aN0M0 invasive lung adenocarcinoma: a clinicopathologic study of 177 patients
Conclusions: Our results showed that the solid- and micropapillary predominant subtype of IASLC/ATS/ERS classification remains the only risk factor for post-operative recurrence of T1aN0M0 adenocarcinomas, suggesting that they can be indicators of aggressive tumor behaviors. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - September 13, 2014 Category: Cancer & Oncology Authors: Fan YangKezhong ChenYida LiaoXiao LiKunkun SunDongmei BaoJun Wang Source Type: research

Capture of Somatic mtDNA Point Mutations with Severe Effects on Oxidative Phosphorylation in Synaptosome Cybrid Clones from Human Brain
This article is protected by copyright. All rights reserved (Source: Human Mutation)
Source: Human Mutation - September 13, 2014 Category: Genetics & Stem Cells Authors: Matthew McKenzie, Maria Chiotis, Jana Hroudová, Maria I. G. Lopez Sanchez, Sze Chern Lim, Mark J. Cook, Penny McKelvie, Richard G. H. Cotton, Michael Murphy, Justin C. St John, Ian A. Trounce Tags: Research Article Source Type: research

Popularity and customer preferences for over-the-counter Chinese medicines perceived by community pharmacists in Shanghai and Guangzhou: a questionnaire survey study
Conclusions: This study identified the top sales categories of OTC Chinese medicines in Shanghai and Guangzhou and the important factors such as drug safety, efficacy, period of validity, contraindications, and indications that are affecting the customer preferences for OTC Chinese medicines. (Source: Chinese Medicine)
Source: Chinese Medicine - September 13, 2014 Category: Complementary Medicine Authors: Shuai GeTian-Tian HeHao Hu Source Type: research

Techniques to ascertain correct endotracheal tube placement in neonates.
CONCLUSIONS: There is insufficient evidence to determine the most effective technique for the assessment of correct ETT placement either in the delivery room or the neonatal intensive care unit. Randomised clinical trials comparing either of these techniques with chest radiography are warranted. PMID: 25217732 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 13, 2014 Category: Journals (General) Authors: Schmölzer GM, Roehr CC Tags: Cochrane Database Syst Rev Source Type: research

A shorter treatment duration may be sufficient for patients with lung disease than with lung disease
This study aimed to compare clinical features and treatment outcomes of M. abscessus and M. massiliense lung disease. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - September 13, 2014 Category: Respiratory Medicine Authors: Jiwon Lyu, Bum-Joon Kim, Byeong-Joon Kim, Jin Woo Song, Chang-Min Choi, Yeon-Mok Oh, Sang Do Lee, Woo Sung Kim, Dong Soon Kim, Tae Sun Shim Source Type: research

Nitrite Modulates Bacterial Antibiotic Susceptibility and Biofilm Formation in Association with Airway Epithelial Cells.
Abstract Pseudomonas aeruginosa is the major pathogenic bacteria in cystic fibrosis and other forms of bronchiectasis. Growth in antibiotic resistant biofilms contributes to the virulence of this organism. Sodium nitrite has antimicrobial properties and has been tolerated as a nebulized compound at high concentrations in human subjects with pulmonary hypertension; however, its effects have not been evaluated on biotic biofilms or in combination with other clinically useful antibiotics. We grew P. aeruginosa on the apical surface of primary human airway epithelial cells to test the efficacy of sodium nitrite against...
Source: Free Radical Biology and Medicine - September 13, 2014 Category: Biology Authors: Zemke AC, Shiva S, Burns JL, Moskowitz SM, Pilewski JM, Gladwin MT, Bomberger JM Tags: Free Radic Biol Med Source Type: research

Effects of dexmedetomidine on cardiorespiratory regulation in spontaneously breathing newborn rats
ConclusionIn spontaneously breathing immature rats, dexmedetomidine administration significantly reduced HR and V′E. Because atipamezole fully reversed decreases in fR and therefore V′E, dexmedetomidine‐related respiratory suppression occurs predominantly through α2‐adrenoceptor‐related suppression of fR. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - September 12, 2014 Category: Anesthesiology Authors: Junko Tamiya, Ryoji Ide, Masayuki Takahashi, Chikako Saiki Tags: Original Article Source Type: research

Evaluation of the systematic error in using 3D dose calculation in scanning beam proton therapy for lung cancer.
In conclusion, the dose error in 3D dose calculation varies from patient to patient and does not correlate with lung tumor motion. Therefore, patient-specific evaluation of the 4D dose is important for scanning beam proton therapy for lung tumors. PMID: 25207565 [PubMed - in process] (Source: Journal of Applied Clinical Medical Physics)
Source: Journal of Applied Clinical Medical Physics - September 12, 2014 Category: Physics Authors: Li H, Liu W, Park P, Matney J, Liao Z, Chang J, Zhang X, Li Y, Zhu RX Tags: J Appl Clin Med Phys Source Type: research

Delivery efficiency of an Elekta linac under gated operation.
In this study, we have characterized the efficiency of an Elekta linac in the delivery of gated radiotherapy. We have explored techniques to reduce the beam-on delay and to improve the delivery efficiency, and have investigated the impact of frequent beam interruptions on the dosimetric accuracy of gated deliveries. A newly available gating interface was installed on an Elekta Synergy. Gating signals were generated using a surface mapping system in conjunction with a respiratory motion phantom. A series of gated deliveries were performed using volumetric modulated arc therapy (VMAT) treatment plans previously generated for...
Source: Journal of Applied Clinical Medical Physics - September 12, 2014 Category: Physics Authors: Cui G, Housley DJ, Chen F, Mehta VK, Shepard DM Tags: J Appl Clin Med Phys Source Type: research

Alabama hospitals see increase in possible enterovirus cases
Emergency rooms around Alabama have been busy after handling increased numbers of sick children suffering from symptoms of a newly emerging respiratory illness. CNN reported that doctors at USA Children's and Women's Hospital in Mobile began to notice a trend in August and said the hospital has treated around 340 children for respiratory illnesses, breathing problems and severe colds, with 45 of them being admitted. The report said patients affected by the recent enterovirus normally stay in the… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - September 12, 2014 Category: Biotechnology Authors: Ryan Phillips Source Type: research

Clinical course of recurrent respiratory papillomatosis: Comparison between aggressiveness of human papillomavirus‐6 and human papillomavirus‐11
ConclusionAnatomically, HPV11‐associated RRP behaves more aggressively. Younger patients with HPV11 and older patients with HPV6 experience a worse clinical course of RRP. © 2014 Wiley Periodicals, Inc. Head Neck, 2014 (Source: Head and Neck)
Source: Head and Neck - September 12, 2014 Category: ENT & OMF Authors: Robin E. A. Tjon Pian Gi, Michel R. M. San Giorgi, Lorian Slagter–Menkema, Bettien M. van Hemel, Bernard F. A. M. van der Laan, Edwin R. van den Heuvel, Frederik G. Dikkers, Ed M.D. Schuuring Tags: Original Article Source Type: research

Highlights from this issue
Firefighters, hang up your hoses (not the articles of female attire!)? These are heady days in the world of cystic fibrosis (CF). Diagnosis is for the most part early by newborn screening (NBS); designer, mutation specific treatments (Ivacaftor, Lumacaftor) are becoming available, and the first ever Gene Therapy trial (does it help, rather than can it be made to happen) will report later this year (see page 962). The treatment paradigm is changing from firefighting the downstream complications of the disease in sick patients to correction of the fundamental molecular defect in the virtually asymptomatic. But are we victims...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Airwaves Source Type: research

Innate immunity in paediatric viral wheezers is virus specific and not interferon dependent
Up to a third of all children develop virus induced wheezing, but we still do not understand why some children wheeze with viral colds and others do not. We also do not know why only some viral wheezers progress to develop asthma and others do not. Data from the Childhood Origins of Asthma Study (COAST) have shown that children with at least one atopic parent who wheeze with viral infections in the first 3 years of life have a significantly increased risk of developing asthma.1 Specifically, wheezing with human rhinovirus (HRV) in the third year of life was associated with up to 30-fold higher risk. However, this asso...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Saglani, S. Tags: Editorial Source Type: research

Setting the stage for CFTR modulator studies in infants
Because irreversible damage to the cystic fibrosis (CF) lung is already observed in infancy, a need has arisen to assess and monitor lung function early in life. Infant lung function testing (ILFT) is non-invasive, does not require radiation or anaesthesia and can be repeated frequently; therefore, development, standardisation and validation of techniques, protocols and equipment have received priority. Thanks to the hard work of many researchers across the globe during the last few decades, we are now able to study and compare development of lung function in the youngest during health and disease.1Through standardisation,...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Merkus, P. J. F. M. Tags: Editorial Source Type: research

Upping the impact: to (not quite!) infinity and beyond
The year 2014 has been a mixed one for Thorax. Sadly, our Golfing Editor in Chief (EIC) has surrendered his trophy (see Airwaves, September). However, this means he is now able to focus more on the Journal in the brief intervals between Bullingdon club meetings. On a better note, we are very happy to announce our new impact factor of 8.562, which has risen to the highest in Thorax history. Chief credit is to the excellence of the manuscripts you have submitted, the editorial team and reviewers for their skill in picking out the best ones from a rich field of choices and the support of the BMJ team. We are still chasing the...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Editorial Source Type: research

Statins as adjunct therapy in COPD: how do we cope after STATCOPE?
Introduction Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are widely used to reduce cardiovascular (CVS) disease risk yet have pleiotropic effects in other organs, including the lungs.1 2 The results of the Simvastatin for the Prevention of Exacerbations in Moderate-to-Severe COPD (STATCOPE) study, that investigated their potential effects on exacerbations of COPD, have been recently published in the New England Journal of Medicine.3 In this Hot off the breath editorial, we review the rationale for the study, discuss its design, main results, strengths and limitations, and speculate on the...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Young, R. P., Hopkins, R. J., Agusti, A. Tags: Clinical trials (epidemiology), Epidemiologic studies, Heart failure, Ischaemic heart disease, Inflammation HOT off the breath Source Type: research

Better survival after lung cancer surgery in high-volume hospitals
In this nationwide database study from England, the association between hospital volume and survival after surgery for non-small cell lung cancer (NSCLC) was investigated. The National Cancer Data Repository was used to extract data on lung cancer diagnosed in England between 2004 and 2008. Survival status was obtained from the National Health Service Central Register and information on surgical resections was acquired from the Hospital Episode Statistics records. Socioeconomic status for each patient was estimated based on the area of residence. Comorbidity information was obtained using diagnosis codes from the Hospital ...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Sartipy, U. Tags: Miscellanea Source Type: research

Comparison of fibulin-3 and mesothelin as markers in malignant mesothelioma
Conclusions Soluble mesothelin is a superior diagnostic biomarker for MM compared with fibulin-3, whereas fibulin-3 provides superior prognostic information compared with mesothelin. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Creaney, J., Dick, I. M., Meniawy, T. M., Leong, S. L., Leon, J. S., Demelker, Y., Segal, A., (Bill) Musk, A. W., Lee, Y. C. G., Skates, S. J., Nowak, A. K., Robinson, B. W. S. Tags: Open access, Respiratory cancer, Occupational and environmental medicine, Environmental issues Biomarkers of disease Source Type: research

Sputum-to-serum hydrogen sulfide ratio in COPD
Conclusions The ratio of sputum-to-serum levels of H2S may provide a useful marker of COPD indicative of obstructive neutrophilic inflammation and of potential ongoing exacerbation. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Saito, J., Mackay, A. J., Rossios, C., Gibeon, D., Macedo, P., Sinharay, R., Bhavsar, P. K., Wedzicha, J. A., Chung, K. F. Tags: Epidemiologic studies, Inflammation, Health education, Smoking, Tobacco use Chronic obstructive pulmonary disease Source Type: research

Evolution of lung function during the first year of life in newborn screened cystic fibrosis infants
Conclusions This is the first study reporting improvements in FEV0.5 over time in stable NBS CF infants treated with standard therapy. Milder changes in lung function occurred by 1 year than previously reported. Lung function at 3 months predicts a high-risk group, who should be considered for intensification of treatment and enrolment into RCTs. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Nguyen, T. T.-D., Thia, L. P., Hoo, A.-F., Bush, A., Aurora, P., Wade, A., Chudleigh, J., Lum, S., Stocks, J., on behalf of the London Cystic Fibrosis Collaboration (LCFC) Tags: Clinical trials (epidemiology), Epidemiologic studies, Open access, Cystic fibrosis, Screening (epidemiology), Screening (public health) Source Type: research

Viral and host factors determine innate immune responses in airway epithelial cells from children with wheeze and atopy
Conclusions AECs from children with wheeze and/or atopy do not have an intrinsic defect in the production of IFN-β or -, however, this response is influenced by the infecting virus. Higher viral load is associated with atopy and wheeze suggesting an impaired antiviral response to RSV and hMPV that is not influenced by production of IFNs. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Spann, K. M., Baturcam, E., Schagen, J., Jones, C., Straub, C. P., Preston, F. M., Chen, L., Phipps, S., Sly, P. D., Fantino, E. Tags: Open access, Drugs: infectious diseases, TB and other respiratory infections, Child health, Asthma Source Type: research

Overdiagnosis of pulmonary emboli by CT pulmonary angiograms
The authors of this article suggest that pulmonary emboli (PEs) are being overdiagnosed by high-resolution CT pulmonary angiography (CTPA), which detect small, isolated subsegmental PEs that are not clinically important. Data from the USA show an 80% rise in the incidence of PEs between 1998 and 2006 after CTPA was introduced. Despite the large increase in diagnosis, age-adjusted mortality from PE (deaths in the US population) has changed little: from 12.3 to 11.9 per 100 000. Presently the best evidence for overdiagnosis comes from a trial that randomised 1417 patients with suspected PE to receive either ventilation&...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Hoda, U. Tags: Miscellanea Source Type: research

IL-27 controls sepsis-induced impairment of lung antibacterial host defence
Conclusions IL-27 is an important mediator of sepsis-induced impairment of lung antibacterial host defence. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Cao, J., Xu, F., Lin, S., Song, Z., Zhang, L., Luo, P., Xu, H., Li, D., Zheng, K., Ren, G., Yin, Y. Tags: Drugs: infectious diseases, Ethics Respiratory infection Source Type: research

A crossover randomised controlled trial of oral mandibular advancement devices for obstructive sleep apnoea-hypopnoea (TOMADO)
Conclusions Non-adjustable MADs achieve clinically important improvements in mild to moderate OSAHS and are cost-effective. Of those trialled, the semi-bespoke MAD is an appropriate first choice. Trial registration number ISRCTN02309506. (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Quinnell, T. G., Bennett, M., Jordan, J., Clutterbuck-James, A. L., Davies, M. G., Smith, I. E., Oscroft, N., Pittman, M. A., Cameron, M., Chadwick, R., Morrell, M. J., Glover, M. J., Fox-Rushby, J. A., Sharples, L. D. Tags: Clinical trials (epidemiology), Editor's choice Sleep Source Type: research

Pulmonary metastasectomy: what is the practice and where is the evidence for effectiveness?
Pulmonary metastasectomy is a commonly performed operation and is tending to increase as part of a concept of personalised treatment for advanced cancer. There have been no randomised trials; belief in effectiveness of metastasectomy is based on registry data and surgical follow-up studies. These retrospective series are comprised predominately of solitary or few metastases with primary resection to metastasectomy intervals longer than 2–3 years. Five-year survival rates of 30–50% are recorded, but as case selection is based on favourable prognostic features, an apparent association between metastasectomy ...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Treasure, T., Milošević, M., Fiorentino, F., Macbeth, F. Tags: Lung neoplasms, Clinical trials (epidemiology), Epidemiologic studies, Open access, Lung cancer (oncology), Lung cancer (respiratory medicine) Review Source Type: research

Cardiovascular event rates in the MOSAIC trial: 2-year follow-up data
The Multicentre Obstructive Sleep Apnoea Intervention Cardiovascular (MOSAIC) trial investigated the effect of continuous positive airway pressure (CPAP) on both sleepiness and predicted cardiovascular risk over 6 months in minimally symptomatic patients with obstructive sleep apnoea. Although there was clear benefit in terms of Epworth Sleepiness Score, there was no improvement in blood pressure and predicted vascular risk score. In order to calculate the required size of future trials, with real vascular events as the endpoint, the rate of such events in this population is needed. 188 patients from the original tria...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Turnbull, C. D., Craig, S. E., Kohler, M., Nicoll, D., Stradling, J. Tags: Epidemiologic studies Research letter Source Type: research

Community-based recruitment of patients with COPD into clinical research
We report our experience and propose that pulmonary rehabilitation and patient groups may represent an enriched pool of COPD patients to recruit into clinical trials. Trial registration number: EudraCT 2011-001063-43 (Source: Thorax)
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Brill, S. E., El-Emir, E., Allinson, J. P., Donaldson, G. C., Nazareth, I., Wedzicha, J. A. Tags: Open access Research letter Source Type: research

Efficacy of lower-limb muscle training modalities in severely dyspnoeic individuals with COPD and quadriceps muscle weakness: results from the DICES trial
Finding an effective rehabilitative modality that does not evoke severe dyspnoea is indeed of great interest to clinicians. The DICES trial aims to identify the optimal training modality by studying the efficacy of high-frequency neuromuscular electrical stimulation (NMES), and low-frequency NMES or strength training in severely dyspnoeic individuals with COPD with quadriceps muscle weakness at baseline. We have some queries regarding the data analysis employed by Sillen et al.1 A power calculation is described in the online supplement which is based on a between-group (intervention vs control) difference of 9.2 kg. W...
Source: Thorax - September 12, 2014 Category: Respiratory Medicine Authors: Chaplin, E., Latimer, L. Tags: PostScript Source Type: research