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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Sequence variants on 17q21 are associated with the susceptibility of asthma in the population of Lahore, Pakistan
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - July 23, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Endotracheal Tube Management and Obstructed Airway
Thoracic surgery encompasses a wide array of surgical techniques, most of which require lung isolation for surgical exposure in the pleural cavity; this, in turn, demands an extensive knowledge of respiratory mechanics and modalities of airway control. Likewise, effective treatment of an acute central airway obstruction calls for a systematic approach using clear communication between teams and a comprehensive knowledge of available therapeutic modalities by the surgeon. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - July 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Manu Sancheti, Seth Force Source Type: research

Dexmedetomidine for tracheal extubation in deeply anesthetized adult patients after otologic surgery: a comparison with remifentanil
Background: Remifentanil and dexmedetomidine are well known to suppress airway reflexes during airway procedures. Smooth tracheal extubation is important after otologic surgery. The purpose of this study is to compare the effectiveness of dexmedetomidine or remifentanil infusion for producing smooth tracheal extubation in deeply anesthetized patients after otologic surgery. Methods: Seventy-four ASA I-II adult patients (18-60 years old) scheduled for elective otologic surgery were randomly assigned to one of three groups: sevoflurane-remifentanil (Group SR, n = 25), sevoflurane-dexmedetomidine (0.5 μg/kg) (Group SD5,...
Source: BMC Anesthesiology - July 23, 2015 Category: Anesthesiology Authors: Qing FanChunbo HuMin YeXia Shen Source Type: research

Humidification devices
Publication date: Available online 21 July 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): David R. Ball Humidification is a process of adding water vapour to a volume of one or more gases. Natural humidification is achieved in the nasal cavity, but this process is often bypassed during anaesthesia and critical care. Various devices are used for artificial humidification, the most common is heat and moisture exchanger combined with a microbial filter. Electrically heated water baths may be used; new devices are combined with high-flow oxygen delivery to provide non-invasive respiratory support. (Sou...
Source: Anaesthesia and intensive care medicine - July 23, 2015 Category: Anesthesiology Source Type: research

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current study, we aimed to determine if exercise training in humans diminished P-CoA attenuation of mitochondrial ADP respiratory sensitivity. Six weeks of exercise training increased whole-body glucose homeostasis and skeletal muscle Akt signaling and reduced markers of oxidative stress without reducing maximal mitochond...
Source: Diabetes - July 23, 2015 Category: Endocrinology Authors: Ludzki, A.; Paglialunga, S.; Smith, B. K.; Herbst, E. A. F.; Allison, M. K.; Heigenhauser, G. J.; Neufer, P. D.; Holloway, G. P. Tags: Metabolism Source Type: research

Human Bocavirus 1 Primary Infection and Shedding in Infants
Conclusions HBoV-1 primary shedding events are associated with mild respiratory illness with subsequent prolonged detection of HBoV-1 DNA for up to a year. HBoV-1 reinfection contributes to long-term shedding. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - July 23, 2015 Category: Infectious Diseases Authors: Martin, E. T., Kuypers, J., McRoberts, J. P., Englund, J. A., Zerr, D. M. Tags: VIRUSES Source Type: research

A case of bronchiolitis obliterans organizing pneumonia in an HIV-infected Korean patient successfully treated with clarithromycin
Conclusion: This case suggests that macrolides are a potential treatment option in HIV-infected patients with mild BOOP. In cases that are otherwise unexplained or unresponsive to treatment, BOOP should be taken into consideration and surgical biopsy performed to confirm a diagnosis of BOOP. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 23, 2015 Category: Infectious Diseases Authors: In JungYong JeonMi-young AhnEunkyong GoagEunHye LeeHea AhnJin AhnNam KuJune KimJun Choi Source Type: research

Management of pain following craniotomy.
Abstract Pain following craniotomy is common, however, achieving effective analgesia can be difficult. The assessment of pain postoperatively can be a challenge in patients who are obtunded (not fully alert) and the severity of pain has historically been underestimated. There are also concerns about side-effects from drugs, particularly with opioids, which may lead to reluctance to administer effective doses. Paracetamol is generally safe and, if given intravenously, provides rapid analgesia, although there are risks associated with overdose and care must be taken to ensure that the safe daily limit is not exceeded...
Source: British Journal of Nursing - July 23, 2015 Category: Nursing Authors: Puntis M, Garner A Tags: Br J Nurs Source Type: research

Infants born before 32 weeks of gestation or with respiratory disease are most likely to receive palivizumab in the Netherlands
ConclusionOnly 15% of eligible infants in the Netherlands received palivizumab and they were mostly born before 32 weeks, in line with Dutch guidelines. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 23, 2015 Category: Pediatrics Authors: Leanne M.A. Kool‐Houweling, Fernie J.A. Penning‐van Beest, Irene D. Bezemer, Richard A. van Lingen, Ron M.C. Herings Tags: Regular Article Source Type: research

Early markers of right heart involvement in regular smokers by Pocket Size Imaging Device
PurposeTo test the diagnostic power of Pocket Size Imaging Device (PSID) in detecting early signs of right heart (RH) involvement in regular smokers (RS) free of overt cardiac involvement. Methods: One-hundred-forty-three regular smokers and 51 healthy controls, comparable for age and sex, underwent physical exam (PE), PSID exam and standard echocardiography. Based on a simplified Boston score, ≥1 of clinical signs (jugular venous distension, hepatomegaly, peripheral pitting oedema and abnormal pulmonary sounds) were considered indicative of RH involvement. A composite score (1 to 4) obtained by summing the points of fou...
Source: Cardiovascular Ultrasound - July 23, 2015 Category: Radiology Authors: Vincenzo Schiano-LomorielloRoberta EspositoCiro SantoroGiovanni de SimoneMaurizio Galderisi Source Type: research

Exhaled breath temperature measurement: Applicability in childhood
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 23, 2015 Category: Respiratory Medicine Authors: Todor A. Popov, Tanya Z. Kralimarkova Tags: Letter to the Editor Source Type: research

An infant with a hyperlucent chest mass: An unexpected diagnosis
We report an unusual finding of pneumatocele in an infant. Case ReportA previously well four month old presented with worsening respiratory distress over 6 weeks. He had no antecedent signs or symptoms of respiratory infection. Chest radiograph demonstrated a lucent hemithorax concerning for tension pneumothorax. Urgent needle decompression was performed. Chest CT showed a persistent dominant macrocyst on the left. Thoracotomy revealed a large cystic lesion necessitating a left lower lobectomy. Histopathology was consistent with a pneumatocele. He remains clinically stable at 16 months postoperatively. DiscussionPneumatoce...
Source: Pediatric Pulmonology - July 23, 2015 Category: Respiratory Medicine Authors: Zarmina Ehsan, Jaimie D. Nathan, Carolyn M. Kercsmar Tags: Case Report Source Type: research

Minimizing the evidence-practice gap – a prospective cohort study incorporating balance training into pulmonary rehabilitation for individuals with chronic obstructive pulmonary disease
Background: We have recently demonstrated the efficacy of balance training in addition to Pulmonary Rehabilitation (PR) at improving measures of balance associated with an increased risk of falls in individuals with Chronic Obstructive Pulmonary Disease (COPD). Few knowledge translation (KT) projects have been conducted in rehabilitation settings. The goal of this study was to translate lessons learnt from efficacy studies of balance training into a sustainable clinical service. Methods: Health care professionals (HCPs) responsible for delivering PR were given an hour of instruction on the principles and practical applicat...
Source: BMC Pulmonary Medicine - July 23, 2015 Category: Respiratory Medicine Authors: Samantha HarrisonMarla BeauchampKathryn SibleyTamara AraujoJulia RomanoRoger GoldsteinDina Brooks Source Type: research

Growth and development after oesophageal atresia surgery: Need for long-term multidisciplinary follow-up
Survival rates in oesophageal atresia patients have reached over 90%. In long-term follow-up studies the focus has shifted from purely surgical or gastrointestinal evaluation to a multidisciplinary approach. We reviewed the literature on the long-term morbidity of these patients and discuss mainly issues of physical growth and neurodevelopment. We conclude that growth problems–both stunting and wasting–are frequently seen, but that sufficient longitudinal data are lacking. Therefore, it is unclear whether catch-up growth into adolescence and adulthood occurs. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - July 23, 2015 Category: Respiratory Medicine Authors: Hanneke IJsselstijn, Saskia J Gischler, Leontien Toussaint, Marjolein Spoel, Monique HM van der Cammen-van Zijp, Dick Tibboel Source Type: research

Reversibility of pulmonary function after inhaling salbutamol in different doses and body postures in asthmatic children
Pulmonary medication is often delivered in the form of medical aerosols designed for inhalation. Recently, breath actuated inhalers (BAI’s) gained popularity as they can be used without spacers. A major drawback of BAI’s is the impaction in the upper airway. Stretching the upper airway by a forward leaning body posture with the neck extended (“sniffing position”) during inhalation may reduce upper airway impaction and improve pulmonary deposition. Aim of this study was to investigate the reversibility of lung function with different doses salbutamol inhaled with a BAI in the forward leaning posture compared to the ...
Source: Respiratory Medicine CME - July 23, 2015 Category: Respiratory Medicine Authors: R. Visser, S. Kelderman, F.H.C. de Jongh, J. van der Palen, B.J. Thio Source Type: research

A randomized controlled trial of vitamin D replacement strategies in pediatric CF patients
Vitamin D insufficiency is common in children with cystic fibrosis (CF), yet data are sparse regarding the most effective form of vitamin D supplementation. The aim of this study was to compare two different vitamin D replacement regimens. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 23, 2015 Category: Respiratory Medicine Authors: Tregony Simoneau, Gregory S. Sawicki, Carly E. Milliren, Henry A. Feldman, Catherine M. Gordon Tags: Original Article Source Type: research

Optical coherence tomography detects structural abnormalities of the nasal mucosa in patients with cystic fibrosis
Chronic inflammation and remodeling of the airways remain a hallmark of cystic fibrosis (CF). However, knowledge of the associated mucosal micro-anatomical changes is limited. We evaluated the potential of optical coherence tomography (OCT) for in vivo imaging of the upper airway mucosa in CF patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 23, 2015 Category: Respiratory Medicine Authors: Ute Oltmanns, Karin Palmowski, Mark Wielpütz, Nicolas Kahn, Eva Baroke, Ralf Eberhardt, Sabine Wege, Matthias Wiebel, Michael Kreuter, Felix J.F. Herth, Marcus A. Mall Tags: Original Article Source Type: research

ASTHMA and COPD: Interchangeable use of inhalers. A document of Italian Society of Allergy, Asthma and Clinical Immmunology (SIAAIC) & Italian Society of Respiratory Medicine (SIMeR)
Publication date: Available online 22 July 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Federico Lavorini, Fulvio Braido, Ilaria Baiardini, Francesco Blasi, Giorgio Walter Canonica Prescription cost-containment measures are increasing in many European countries and, as more inhaler devices become available, there may be pressure to switch patients from reference listed inhaler medication to cheaper generic inhaler drugs. Indeed, in some countries, such a substitution is mandated by current regulations, and patients who do not accept the substitution have to pay the difference in cost. Generic...
Source: Pulmonary Pharmacology and Therapeutics - July 23, 2015 Category: Respiratory Medicine Source Type: research

Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Wenjia Chen, Jamie Thomas, Mohsen Sadatsafavi, J Mark FitzGerald Background Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disorder associated with increased comorbid prevalence of cardiovascular diseases. We aimed to quantify the magnitudes of association between overall and specific types of cardiovascular disease, major cardiovascular risk factors, and COPD. Methods We searched Cochrane, Medline, and Embase databases for studies published between Jan 1, 1980, and April 30, 2015, on the preval...
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Should countries implement Xpert MTB/RIF when empirical treatment precludes a clinical effect?
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Annelies Van Rie (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Social network analysis of Pseudomonas aeruginosa in cystic fibrosis
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): David C Taylor-Robinson, Kevin W Southern, Craig Winstanley (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

A new phase of CFTR treatment for cystic fibrosis?
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Scott C Bell (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: a prospective burden of disease study with a nested randomised controlled trial
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Gregory L Calligaro, Grant Theron, Hoosain Khalfey, Jonathan Peter, Richard Meldau, Brian Matinyenya, Malika Davids, Liezel Smith, Anil Pooran, Maia Lesosky, Aliasgar Esmail, Malcolm G Miller, Jenna Piercy, Lancelot Michell, Rodney Dawson, Richard I Raine, Ivan Joubert, Keertan Dheda Background There are few prospective data about the incidence and mortality associated with pulmonary tuberculosis in intensive care units (ICUs), and none on the accuracy and clinical effect of the Xpert-MTB/RIF assay in this ...
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

The social network of cystic fibrosis centre care and shared Pseudomonas aeruginosa strain infection: a cross-sectional analysis
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Timothy J Kidd, Ricardo J Soares Magalhães, Stuart Paynter, Scott C Bell Background Person-to-person transmission is a potential pathway of Pseudomonas aeruginosa acquisition in cystic fibrosis. Reports of cross-infection of shared cystic-fibrosis-specific P aeruginosa strains across large geographical distances are concerning. Therefore, we aimed to assess the extent to which patient movement between cystic fibrosis centres contributes to dissemination. Methods We did a cross-sectional study to assess movement of pati...
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Cardiovascular disease in patients with COPD
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Mario Cazzola, Paola Rogliani, Maria Gabriella Matera (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Rethinking COPD diagnosis: imaging and GOLD criteria
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Sanjay Tanday (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Extended warfarin treatment after pulmonary embolism
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

WHO tobacco report focuses on increased taxation
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Talha Khan Burki (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity
Conclusions This work illustrates how combining advanced sequencing techniques with phenotypic data addresses extreme genetic heterogeneity to provide diagnostic and carrier testing, guide medical monitoring for progressive complications, facilitate interpretation of genome-wide sequencing results in individuals with a variety of phenotypes and enable gene-specific treatments in the future. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - July 23, 2015 Category: Genetics & Stem Cells Authors: Bachmann-Gagescu, R., Dempsey, J. C., Phelps, I. G., O'Roak, B. J., Knutzen, D. M., Rue, T. C., Ishak, G. E., Isabella, C. R., Gorden, N., Adkins, J., Boyle, E. A., de Lacy, N., O'Day, D., Alswaid, A., Ramadevi A, R., Lingappa, L., Lourenco, C., Martorell Tags: Liver disease, Eye Diseases, Editor's choice, Genetic screening / counselling, Memory disorders (psychiatry) Genotype-phenotype correlations Source Type: research

Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder
Conclusions Our findings indicate that mutations in CARS2 result in a mitochondrial translational defect as seen in individuals with mitochondrial epileptic encephalopathy. (Source: Journal of Medical Genetics)
Source: Journal of Medical Genetics - July 23, 2015 Category: Genetics & Stem Cells Authors: Coughlin, C. R., Scharer, G. H., Friederich, M. W., Yu, H.-C., Geiger, E. A., Creadon-Swindell, G., Collins, A. E., Vanlander, A. V., Coster, R. V., Powell, C. A., Swanson, M. A., Minczuk, M., Van Hove, J. L. K., Shaikh, T. H. Tags: Genetic screening / counselling, Immunology (including allergy), Epilepsy and seizures, Muscle disease, Neuromuscular disease, Metabolic disorders New loci Source Type: research

Plectin isoform P1b and P1d deficiencies differentially affect mitochondrial morphology and function in skeletal muscle
In this study, we demonstrate that structural and functional alterations of mitochondria are a primary aftermath of plectin deficiency in muscle, contributing to myofiber degeneration. We found that in skeletal muscle of conditional plectin knockout mice (MCK-Cre/cKO), mitochondrial content was reduced, and mitochondria were aggregated in sarcoplasmic and subsarcolemmal regions and were no longer associated with Z-disks. Additionally, decreased mitochondrial citrate synthase activity, respiratory function and altered adenosine diphosphate kinetics were characteristic of plectin-deficient muscles. To analyze a mechanistic l...
Source: Human Molecular Genetics - July 23, 2015 Category: Genetics & Stem Cells Authors: Winter, L., Kuznetsov, A. V., Grimm, M., Zeold, A., Fischer, I., Wiche, G. Tags: ARTICLES Source Type: research

Mitochondrial respiratory dysfunction caused by a heteroplasmic mitochondrial DNA mutation blocks cellular reprogramming
Mitochondrial dysfunction caused by pathogenic mutations in mitochondrial tRNA genes emerges only when mutant mitochondrial DNA (mtDNA) proportions exceed intrinsic pathogenic thresholds; however, little is known about the actual proportions of mutant mtDNA that can affect particular cellular lineage-determining processes. Here, we mainly focused on the effects of mitochondrial respiratory dysfunction caused by m.3243A>G heteroplasmy in MT-TL1 gene on cellular reprogramming. We found that generation of induced pluripotent stem cells (iPSCs) was drastically depressed only by high proportions of mutant mtDNA (≥90% m.32...
Source: Human Molecular Genetics - July 23, 2015 Category: Genetics & Stem Cells Authors: Yokota, M., Hatakeyama, H., Okabe, S., Ono, Y., Goto, Y.-i. Tags: ARTICLES Source Type: research

Genes, Vol. 6, Pages 672-684: Complete Genomic Characterization of Porcine Reproductive and Respiratory Syndrome Virus Strain HB-XL
Porcine reproductive and respiratory syndrome virus (PRRSV) is the causal agent of a serious disease of swine. Here, we report the genome sequence of PRRSV strain HB-XL isolated from a pig farm with a clinical outbreak of porcine reproductive and respiratory syndrome. The genome is 15,323 bp long and has nine open reading frames (GenBank: KP162169). Comparative and phylogenetic analysis showed that HB-XL belongs to the highly pathogenic PRRSV (HP-PRRSV) subfamily in the family PRRSV. The viral nonstructural protein 2 (Nsp2) of the HB-XL strain contained 30 discontinuous amino acid (AA) deletions relative to that of the Nsp...
Source: Genes - July 23, 2015 Category: Genetics & Stem Cells Authors: Yi ZuoWanzhe YuanJiguo Sun Tags: Article Source Type: research

The outcome of acute respiratory distress syndrome in relation to body mass index and diabetes mellitus
To determine the 28 day mortality of patients with ARDS in relation to body mass index (BMI) and presence diabetes mellitus (DM). (Source: Heart and Lung)
Source: Heart and Lung - July 23, 2015 Category: Intensive Care Authors: Ayman O. Soubani, Wei Chen, Hyejeong Jang Source Type: research

Pro-inflammatory Signature of the Dysfunctional Endothelium in Pulmonary Hypertension: Role of MIF/CD74 Complex.
CONCLUSIONS: We report here that CD74 and MIF are markedly increased and activated in iPAH patients, contributing to the abnormal pro-inflammatory phenotype of pulmonary ECs in iPAH. PMID: 26203495 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 23, 2015 Category: Respiratory Medicine Authors: Le Hiress M, Tu L, Ricard N, Phan C, Thuillet R, Fadel E, Dorfmüller P, Montani D, de Man F, Humbert M, Huertas A, Guignabert C Tags: Am J Respir Crit Care Med Source Type: research