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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Network Analysis in the Investigation of Chronic Respiratory Diseases: from Basics to Application.
Abstract Chronic respiratory diseases are complex multifactorial disorders whose pathogenesis depends on the interplay between host and environmental factors. To fully understand them and to identify novel treatments, a holistic approach that integrates multiple types and levels of clinical and biological data is necessary. Towards this end, the application of systems biology-based strategies, in particular, network analysis, offers great potential. These systems-based approaches rely heavily upon computational methods that can be challenging for the non-specialist. Accordingly, this Pulmonary Perspective: (1) outl...
Source: American Journal of Respiratory and Critical Care Medicine - September 25, 2014 Category: Respiratory Medicine Authors: Diez D, Agusti A, Wheelock CE Tags: Am J Respir Crit Care Med Source Type: research

Mitochondrial Presequence Translocase [Cell Biology]
The majority of mitochondrial proteins are synthesized with amino-terminal signal sequences. The presequence translocase of the inner membrane (TIM23 complex) mediates the import of these preproteins. The essential TIM23 core complex closely cooperates with partner protein complexes like the presequence translocase-associated import motor and the respiratory chain. The inner mitochondrial membrane also contains a large number of metabolite carriers, but their association with preprotein translocases has been controversial. We performed a comprehensive analysis of the TIM23 interactome based on stable isotope labeling with ...
Source: Journal of Biological Chemistry - September 25, 2014 Category: Chemistry Authors: Mehnert, C. S., Rampelt, H., Gebert, M., Oeljeklaus, S., Schrempp, S. G., Kochbeck, L., Guiard, B., Warscheid, B., van der Laan, M. Tags: Membrane Biology Source Type: research

Early Exposure to Hyperoxia or Hypoxia Adversely Impacts Cardio-Pulmonary Development.
In conclusion, exposure of newborn mice to hyperoxia or hypoxia leads to cardiopulmonary abnormalities in adult life, similar to that described in ex-preterm infants. This animal model may help identify underlying mechanisms and for development of therapeutic strategies for pulmonary morbidity in former preterm infants. PMID: 25255042 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - September 25, 2014 Category: Respiratory Medicine Authors: Ramani M, Bradley WE, Dell'Italia LJ, Ambalavanan N Tags: Am J Respir Cell Mol Biol Source Type: research

Household Air Pollution Causes Dose-dependent Inflammation and Altered Phagocytosis in Human Macrophages.
Conclusion Alveolar macrophage function is altered by particulate loading. Our macrophage model is comparable morphologically to the in vivo uptake of particulates. Wood smoke exposed cells demonstrate reduced phagocytosis but unaffected mycobacterial killing, suggesting defects related to chronic wood smoke inhalation limited to specific innate immune functions. PMID: 25254931 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - September 25, 2014 Category: Respiratory Medicine Authors: Rylance J, Fullerton DG, Scriven J, Aljurayyan AN, Mzinza D, Barrett S, Wright AK, Wootton DG, Glennie SJ, Baple K, Knott A, Mortimer K, Russell DG, Heyderman RS, Gordon SB Tags: Am J Respir Cell Mol Biol Source Type: research

Canadian recommendations for critical care ultrasound training and competency.
PMID: 25255460 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 25, 2014 Category: Respiratory Medicine Authors: Arntfield R, Millington S, Ainsworth C, Arora R, Boyd J, Finlayson G, Gallagher W, Gebhardt C, Goffi A, Hockman E, Kirkpatrick A, McDermid R, Waechter J, Wong N, Zalvalkoff S, Beaulieu Y Tags: Can Respir J Source Type: research

Single-Dose Etomidate Does Not Increase Mortality in Patients with Sepsis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.
Conclusions:Current evidence indicates that single-dose etomidate does not increase mortality in patients with sepsis. However, this finding largely relies on data from observational studies, potentially subject to selection bias, and hence high-quality and adequately powered RCTs are warranted. Background: The effect of single-dose etomidate on mortality in patients with sepsis remains controversial. We systematically reviewed the literature to investigate whether a single-dose etomidate for rapid sequence intubation increased mortality in patients with sepsis. Methods: PubMed, Embase, and CENTRAL were searched fo...
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Gu WJ, Wang F, Tang L, Liu JC Tags: Chest Source Type: research

Optimal Duration of Anti-tuberculosis Treatment in Diabetic Patients: Nine or Six months?
Conclusions:The two-year TB recurrence rate is higher in diabetic population in Taiwan and can be reduced by treatment supervision. Extending the anti-TB treatment by three months may also decrease the recurrence rate when treatment is not supervised. Introduction: Diabetes mellitus (DM) increases the risk of tuberculosis (TB) recurrence. This study investigated whether nine-month anti-TB treatment is associated with a lower risk of TB recurrence within two years after complete treatment than six-month treatment in DM patients with an emphasis on the impact of directly observed therapy, short course (DOTs). Methods...
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Wang JY, Lee MC, Shu CC, Lee CH, Lee LN, Chao KM, Chang FY Tags: Chest Source Type: research

Derivation and validation of a CT scoring system for discriminating malignant from benign pleural effusions.
Conclusions:A simple CT-based scoring system can help physicians to separate malignant from benign pleural effusions. Background: Chest computed tomography (CT) has become an integral part of the work-up for undiagnosed pleural effusions. We aimed to develop a CT scan-based scoring system for differentiating between benign and malignant pleural effusions. Methods: A number of chest CT abnormalities were compared between 228 patients with benign and 115 with malignant effusions (derivation cohort). A logistic regression analysis was used to identify the independent predictors of malignancy and generate CT scores, wi...
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Porcel JM, Pardina M, Bielsa S, González A, Light RW Tags: Chest Source Type: research

The Association of Direct Thrombin Inhibitor Anticoagulants with Cardiac Thromboses.
Abstract Direct thrombin inhibitor (anti-factor IIa) anticoagulants, now established for treatment and prevention of cardiac and venous thromboembolism, have been repeatedly associated with a significantly increased frequency of thrombosis on abnormal cardiac endothelium when compared head-to-head with indirectly-acting therapeutic anticoagulants in studies of sufficient patient number and duration. Although there is uncertainty as to mechanism, the weight of evidence as a class effect warrants prescribing effective anticoagulants other than direct thrombin inhibitors. PMID: 25254608 [PubMed - as supplied by pu...
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Davidson BL Tags: Chest Source Type: research

Secular changes in relative leg length confound height-based spirometric reference values.
Conclusions:In low income countries improving health conditions are likely to drive increases in height and changes in relative leg length similar to those observed in Japan, and thus to a change in body frame. This implies that height based prediction equations for such populations will need to be periodically updated. Background: Most but not all data from different ethnic groups fit the Global Lung Function Initiative (GLI) spirometric reference model. This study investigates to what extent discrepancies are caused by secular changes in body proportions. Methods: Forced expiratory volume in one second (FEV1) and...
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Quanjer PH, Kubota M, Kobayashi H, Omori H, Tatsumi K, Kanazawa M, Stanojevic S, Stocks J, Cole TJ Tags: Chest Source Type: research

Platelet count mediates the contribution of a genetic variant in LRRC16A to acute respiratory distress syndrome risk.
Conclusions: Our findings support the role of LRRC16A in platelet formation, and suggest the importance of LRRC16A in ARDS pathophysiology by interacting with, and being mediated through, platelet. PMID: 25254322 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - September 25, 2014 Category: Respiratory Medicine Authors: Wei Y, Wang Z, Su L, Chen F, Tejera P, Bajwa EK, Wurfel MM, Lin X, Christiani DC Tags: Chest Source Type: research

Indoor Environmental and Air Quality Characteristics, Building-Related Health Symptoms, and Worker Productivity in a Federal Government Building Complex.
Abstract Abstract. Building Health Sciences, Inc. (BHS) investigated environmental conditions by many modalities in 71 discreet areas of 12 buildings in a government building complex which had experienced persistent occupant complaints despite correction of deficiencies following a prior survey. An on-line health survey was completed by 7,637 building occupants (49% response rate), a sub-set of whom voluntarily wore personal sampling apparatus and underwent medical evaluation. Building environmental measures were within current standards and guidelines, with few outliers. Four environmental factors were consistentl...
Source: Archives of Environmental and Occupational Health - September 25, 2014 Category: Environmental Health Authors: Lukcso D, Guidotti TL, Franklin DE, Burt A Tags: Arch Environ Occup Health Source Type: research

Epilithonimonas xixisoli sp. nov., isolated from bank side soil.
Abstract A novel Gram-staining-negative, non-motile and rod-shaped bacterial strain containing flexirubin-type pigments, designated S31T, was isolated from bank side soil of the Xixi wetland in Zhejiang province, China. Growth occurred at 10-37°C (optimum, 32°C), pH 6-8 (optimum, pH 7) and with 0-2% (w/v) NaCl (optimum, 1%). Stain S31T had highest 16S rRNA gene similarities with the type stain of Epilithonimonas lactis H1T (96.2%), and Chryseobacterium molle DW3T (96.4%). Phylogenetic analysis suggested that strain S31T was a member of the genus Epilithonimonas. The dominant respiratory quinone was MK-6 and the G...
Source: International Journal of Systematic and Evolutionary Microbiology - September 25, 2014 Category: Microbiology Authors: Feng H, Zeng Y, Huang Y Tags: Int J Syst Evol Microbiol Source Type: research

Celeribacter indicus sp. nov. a polycyclic aromatic hydrocarbon-degrading bacterium from deep-sea sediment and reclassification of Huaishuia halophila as Celeribacter halophilus comb. nov.
Abstract A taxonomic study was carried out on strain P73T, which was isolated from deep-sea sediment of the Indian Ocean by enrichment of polycyclic aromatic hydrocarbons. It can degrade biphenyl, naphthalene, 2-methylnaphthalene, 2,6-dimethylnaphthalene, acenaphthene, anthracene, phenanthrene, dibenzothiophene, dibenzofuran, fluorene, 4-methyldibenzothiophene and fluoranthene, but not pyrene or chrysene. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain P73T formed a clade with the genera Celeribacter and Huaishuia within the family Rhodobacteraceae, with highest sequence similarity of 96.9...
Source: International Journal of Systematic and Evolutionary Microbiology - September 25, 2014 Category: Microbiology Authors: Lai Q, Cao J, Yuan J, Li F, Shao Z Tags: Int J Syst Evol Microbiol Source Type: research

Aquimarina penaei sp. nov., isolated from intestinal tract contents of Pacific white shrimp, Penaeus vannamei.
Abstract A novel bacterial strain designated P3-1(T) was isolated from the intestinal tract contents of Pacific white shrimp (Penaeus vannamei) in Zhangpu, Fujian province, China. The isolate was found to be Gram-negative, long rod shaped, oxidase- and catalase- positive. Growth was observed at 1-7 % sea salt (w/v, optimum, 3 %), at pH 7.0-9.0 (optimum, pH 7.0) and at 10-37 °C (optimum, 28 °C). The isolate was capable of hydrolysing gelatin, casein, starch and DNA but unable to degrade Tween 20, 40, 80 and cellulose. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain P3-1(T) belongs ...
Source: Antonie van Leeuwenhoek - September 25, 2014 Category: Microbiology Authors: Li X, Wang L, Huang H, Lai Q, Shao Z Tags: Antonie Van Leeuwenhoek Source Type: research

A randomised controlled trial of roller versus centrifugal cardiopulmonary bypass pumps in patients undergoing pulmonary endarterectomy.
CONCLUSIONS: We have shown that the use of a centrifugal pump during prolonged cardiopulmonary bypass and deep hypothermic circulatory arrest is associated with a reduced inflammatory response compared to the standard roller pump. Larger multi-centre trials in this area of practice are required. PMID: 25258197 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 25, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Mlejnsky F, Klein A, Lindner J, Maruna P, Kvasnicka J, Kvasnicka T, Zima T, Pecha O, Lips M, Rulisek J, Porizka M, Kopecky P, Kunstyr J Tags: Perfusion Source Type: research

Tissue-Engineered Tracheal Reconstruction Using Mesenchymal Stem Cells Seeded on a Porcine Cartilage Powder Scaffold.
Abstract Tissue engineering using a biocompatible scaffold with various cells might be a solution for tracheal reconstruction. We investigated the plausibility of using mesenchymal stem cells (MSCs) seeded on a porcine cartilage powder (PCP) scaffold for tracheal defect repair. PCP made with minced and decellularized porcine articular cartilage was molded into a 5 × 12 mm (height × diameter) scaffold. MSCs from young rabbit bone marrow were expanded and cultured with the PCP scaffold. After 7 weeks culture, the tracheal implants were transplanted on a 5 × 10 mm tracheal defect in six rabbits. 6 and 10 ...
Source: Annals of Biomedical Engineering - September 25, 2014 Category: Biomedical Engineering Authors: Shin YS, Choi JW, Park JK, Kim YS, Yang SS, Min BH, Kim CH Tags: Ann Biomed Eng Source Type: research

Ex utero intrapartum treatment for an infant with cerebro‐costo‐mandibular syndrome
Abstract Cerebro‐costo‐mandibular syndrome (CCMS) is a rare disorder characterized by multiple rib abnormalities, micrognathia described as Pierre–Robin sequence, and cerebral involvement. Appropriate management of respiratory distress immediately after birth is crucial to rescue these patients. A boy, having a mother with Pierre–Robin sequence and a sister with CCMS, was diagnosed prenatally with CCMS and successfully treated with ex utero intrapartum treatment (EXIT) at 36 weeks 6 days of gestation. EXIT would be an effective option for rescuing patients with prenatally diagnosed CCMS and preventing neonatal ...
Source: Pediatrics International - September 24, 2014 Category: Pediatrics Authors: Kei Ogasawara, Yoshinobu Honda, Mitsuaki Hosoya Tags: Patient Report Source Type: research

Case of Desbuquois dysplasia type 1: Potentially lethal skeletal dysplasia
We report a boy with Desbuquois dysplasia type 1. He had the typical skeletal changes: a “Swedish key” appearance of the proximal femora; advanced carpal ossification and other distinctive features of the hand, including an extra‐ossification center at the base of the proximal phalanx of the index and middle fingers; dislocation of the metacarpophalangeal joint of the index finger; and bifid distal phalanx of the thumb. In addition, he presented with very severe prenatal growth failure, respiratory distress as a neonate, subsequent failure to thrive and susceptibility to airway infection, and sudden death in early ch...
Source: Pediatrics International - September 24, 2014 Category: Pediatrics Authors: Shinkai Inoue, Atsushi Ishii, Goro Shirotani, Makoto Tsutsumi, Eiji Ohta, Masatoshi Nakamura, Toshiko Mori, Takahito Inoue, Gen Nishimura, Atsushi Ogawa, Shinichi Hirose Tags: Patient Report Source Type: research

Respiratory Hemodynamics in the Hepatic Veins—Abnormal Patterns
The flow pattern in the hepatic veins (HVs) is dependent on the cardiac cycle and right heart hemodynamics and influenced by the respiratory cycle and the liver parenchyma. Most disease states that affect the right heart alter the HV Doppler in a manner independent of the respiratory cycle. Some diseases that typically involve the pericardium, right ventricular myocardium, or respiratory system confer characteristic changes to the HV flow in a manner dependent on the respiratory cycle. Analysis of the HV Doppler with assessment of the respiratory changes in flow and their timing helps to distinguish among the various disea...
Source: Echocardiography - September 24, 2014 Category: Cardiology Authors: Bahaa M. Fadel, Ahmad Alkalbani, Aysha Husain, Ziad Dahdouh, Giovanni Di Salvo Tags: Doppler Hemodynamics Source Type: research

Factors affecting mortality following emergency admission for chronic obstructive pulmonary disease
Conclusions: Our study demonstrated that all-cause in-hospital mortality in patients with COPD who required emergency hospitalization was associated with deteriorated general conditions and comorbidities at admission. Physicians should take into account these prognostic factors to choose better treatment options for COPD patients. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - September 24, 2014 Category: Respiratory Medicine Authors: Wakae HasegawaYasuhiro YamauchiHideo YasunagaMitsuhiro SunoharaTaisuke JoHiroki MatsuiKiyohide FushimiKazutaka TakamiTakahide Nagase Source Type: research

Network medicine analysis of COPD multimorbidities
Conclusions: The network medicine approach presented here allowed the identification of plausible molecular links between COPD and comorbid diseases, and showed that many of them are targets of the tobacco exposome, proposing new areas of research for understanding the molecular underpinning of COPD multimorbidities. (Source: Respiratory Research)
Source: Respiratory Research - September 24, 2014 Category: Respiratory Medicine Authors: Solène GrosdidierAntoni FerrerRosa FanerJanet PiñeroJosep RocaBorja CosíoAlvar AgustíJoaquim GeaFerran SanzLaura Furlong Source Type: research

Fluticasone propionate/salmeterol 250/50 ¿g versus salmeterol 50 ¿g after chronic obstructive pulmonary disease exacerbation
Conclusions: No significant treatment difference between FP/SAL and SAL was seen in COPD exacerbation recurrence for the complete cohort. Treatment benefit with FP/SAL over SAL (treatment ratio 0.68 [0.47, 0.97]) was seen in patients having FEV1???30% and prior exposure to ICS. No unexpected safety issues were identified with either treatment. Patients with the most severe COPD may be more refractory to treatment.Trial registrationClinicalTrials.gov (identifier NCT01110200). This study was funded by GlaxoSmithKline (study number ADC113874). (Source: Respiratory Research)
Source: Respiratory Research - September 24, 2014 Category: Respiratory Medicine Authors: Jill OharGlenn CraterAmanda EmmettThomas FerroAndrea MorrisIbrahim RaphiouPeruvemba SriramMark Dransfield Source Type: research

Smoking accelerates aging of the small airway epithelium
By studying age-related gene expression and telomere length, smoking has been shown to accelerate aging of the small airway epithelium at the molecular level prior to the clinical manifestation of lung disease. (Source: Respiratory Research)
Source: Respiratory Research - September 24, 2014 Category: Respiratory Medicine Authors: Matthew WaltersBishnu DeJacqueline SalitLauren Buro-AuriemmaTimothy WilsonAllison RogalskiLindsay LiefNeil HackettMichelle StaudtAnn TilleyBen-Gary HarveyRobert KanerJason MezeyBeth AshbridgeMalcolm MooreRonald Crystal Source Type: research

The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort
DiscussionThe results obtained in WHZH cohort study may increase a better understanding of the relationship between particulate air pollution and its components and possible health damages. And the potential mechanisms underlying the development of cardiopulmonary diseases has implications for the development of prevention and treatment strategies. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - September 24, 2014 Category: Consumer Health News Authors: Yuanchao SongJian HouXiji HuangXiaomin ZhangAijun TanYi RongHuizhen SunYun ZhouXiuqing CuiYuqing YangYanjun GuoZhihong ZhangXin LuoBing ZhangFan HouXiaosheng HeJungang XieTangchun WuJing YuanWeihong Chen Source Type: research

Do extra compulsory physical education lessons mean more physically active children - findings from the childhood health, activity, and motor performance school study Denmark (The CHAMPS-study DK)
Background: Primarily, this study aims to examine whether children attending sports schools are more active than their counterpart attending normal schools. Secondary, the study aims to examine if physical activity (PA) levels in specific domains differ across school types. Finally, potential modifications by status of overweight/obesity and poor cardio-respiratory fitness are examined. Methods: Participants were from the first part of the CHAMPS-study DK, which included approximately 1200 children attending the 0th ? 6th grade. At the sports schools, the mandatory physical education (PE) program was increased from 2 to 6 ...
Source: International Journal of Behavioral Nutrition and Physical Activity - September 24, 2014 Category: Nutrition Authors: Niels MøllerJakob TarpEva KamelarczykJan BrøndHeidi KlakkNiels Wedderkopp Source Type: research

Tobacco exposure and susceptibility to tuberculosis: is there a smoking gun?
In many regions of the world, there is a great overlap between the prevalence of cigarette smoke exposure and tuberculosis. Despite the large body of epidemiologic evidence that tobacco smoke exposure is associated with increased tuberculosis infection, active disease, severity of disease, and mortality from tuberculosis, these studies cannot distinguish whether the mechanism is principally through direct impairment of anti-tuberculosis immunity by cigarette smoke or due to potential confounders that increase risk for tuberculosis and are commonly associated with smoking – such as poverty, malnutrition, and crowded livin...
Source: Tuberculosis - September 24, 2014 Category: Respiratory Medicine Authors: Edward D. Chan, William H. Kinney, Jennifer R. Honda, Raju Bishwakarma, Avani Gangavelli, Jenny Mya, Xiyuan Bai, Diane J. Ordway Tags: Review Source Type: research

Prognostic factors for discharge destination after acute stroke: a comprehensive literature review.
Conclusion: Patient initial medical care, age and sex, neurological and medical complications and environmental/socio-economic factors should be considered in the decision-making process for discharge destination. [Box: see text]. PMID: 25250810 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
Source: Disability and Rehabilitation - September 24, 2014 Category: Rehabilitation Authors: Van der Cruyssen K, Vereeck L, Saeys W, Remmen R Tags: Disabil Rehabil Source Type: research

Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and is Associated with Increased Mortality in Non-small Cell Lung Cancer.
Conclusions: Taken together, these findings suggest that MMP19 is associated with the development and progression of NSCLC and may be a potential biomarker of disease severity and outcome. PMID: 25250855 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 24, 2014 Category: Respiratory Medicine Authors: Yu G, Herazo-Maya JD, Nukui T, Romkes M, Parwani A, Juan-Guardela BM, Robertson J, Gauldie J, Siegfried JM, Kaminski N, Kass DJ Tags: Am J Respir Crit Care Med Source Type: research

B Cell Depletion Increases Sphingosine-1-phosphate-dependent Airway Inflammation in Mice.
Abstract Sphingosine-1-phosphate (S1P) has been widely associated to inflammation-based lung pathologies. Because B cells play a critical role as antigen presenting and/or immunoglobulin-producing cells during asthmatic conditions, we wanted to dissect the role of these cells in S1P-dependent airway hyper-reactivity and inflammation. Mice were sensitized to ovalbumin (OVA) or exposed to S1P. OVA sensitization caused airway hyper-reactivity coupled to an increased lung infiltration of B cells, which was significantly reduced after the inhibition of sphingosine kinases (SphKI/II). Similarly, the sole administration o...
Source: Am J Respir Cell Mol... - September 24, 2014 Category: Respiratory Medicine Authors: Sorrentino R, Bertolino A, Terlizzi M, Iacono VM, Maiolino P, Cirino G, Roviezzo F, Pinto A Tags: Am J Respir Cell Mol Biol Source Type: research

How do respiratory patients perceive oxygen therapy? A critical interpretative synthesis of the literature.
Abstract Oxygen therapy is a common intervention in health care worldwide; yet, despite universal use, it is evident through poor practice that oxygen is often prescribed and administered injudiciously. It is proposed that possibly an influencing culture presides, whereby oxygen is often poorly understood and uncertainty regarding its use exists. It is unclear where the origins of this culture lie but exploring perceptions may enlighten the problem. A review of the literature was undertaken to establish what is already known about this elusive phenomenon. The paucity of any direct evidence regarding perceptions of ...
Source: Chronic Respiratory Disease - September 24, 2014 Category: Respiratory Medicine Authors: Kelly CA, Maden M Tags: Chron Respir Dis Source Type: research

598p * cetuximab plus mfolfox-6 as first-line therapy for patients with kras wild-type unresectable colorectal liver-limited metastases: an open, non-randomized, multicenter phase ii clinical trial (clime study)
Conclusions: With interim analyses combination therapy comprising cetuximab and mFOLFOX-6 was well tolerated with acceptable ORR, R0 resection rates and PFS.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Cai, S., Zhang, W., Li, W., Xu, Y., Gu, W., Guan, Z., Cai, J., Song, C., Xu, J., Chi, P., Lin, J., Zhang, K., Li, D., Wang, X., Pei, H., Zhang, X., Wan, D., Wang, J., Dang, C., Yuan, X. Tags: gastrointestinal tumours, colorectal Source Type: research

680p * phase ii study of a combination chemotherapy with weekly docetaxel and gemcitabine in previously treated metastatic esophageal squamous cell cancer
Conclusions: The weekly combination of docetaxel and FDR gemcitabine showed a promising antitumor activity and tolerability in previously treated, metastatic esophageal SCC.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Lee, M., Jung, K. S., Kim, H. S., Lee, J. Y., Lim, S. H., Kim, M., Jung, H. A., Kim, S. M., Lee, J., Lim, D. H., Park, K. W., Yi, S. Y., Hwang, I. G., Lee, S., Ahn, H. K., Park, S. H. Tags: gastrointestinal tumours, non-colorectal Source Type: research

914p * comorbidities and adverse events in advanced and recurrent ovarian cancer patients in france
Conclusions: In a European hospital-based study of advanced or recurrent ovarian cancer patients, one in three patients were reported to have a comorbidity, and four in five reported a mild adverse event. The incidence rates reported in this study are comparable to those reported in previous European-based studies.Disclosure: A. Taylor, V. Chia and G. Kafatos: is employed by Amgen Ltd and owns Amgen stock;D. Pillas: is employed by Amgen Ltd; G. Freyer: is a consultant for Amgen France. All other authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Le Saux, O., Taylor, A., Chia, V., Pillas, D., Kafatos, G., Freyer, G. Tags: gynaecological cancers Source Type: research

1004p * symptom prevalence and functional status among patients with advanced cancers of the head and neck
Conclusions: With this prospective study we have clarified symptoms in terminally ill patients with head and neck cancers. On the basis of this study, we plan to establish a care system for terminally ill patients with head and neck cancers and prepare further prospective studies.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Shinozaki, T., Ebihara, M., Iwase, S., Yamaguchi, T., Hirakawa, H., Shimbashi, W., Kamijo, T., Okamoto, M., Beppu, T., Ohori, J., Matsuura, K., Suzuki, M., Nishino, H., Sato, Y., Ariyoshi, K., Matoba, M. Tags: head and neck cancer Source Type: research

1182pd * prognostic factors in resected ais, mia and lepidic predominant lung adenocarcinoma
Conclusions: The overall survival and freedom from recurrence rates were good in lepidic predominant adenocarcinoma. TNM stage (II-III vs. I) was a significant predictive factor of freedom from recurrence in these patients.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Hung, J., Chou, T., Hsu, W., Wu, Y. Tags: NSCLC, early stage Source Type: research

1239p * feasibility of home delivery (hd) of maintenance pemetrexed (pem) therapy for advanced nonsquamous non small cell lung cancer (adv nsqnsclc)
Conclusions: HD of maintenance PEM therapy in adv nsqNSCLC was feasible, safe, and preferred by patients, while maintaining HRQoL. Physicians were satisfied with distant patient management. Community-based clinical research requires specific consideration and resource allocation.Disclosure: M.C. Nicolson: The author has a personal specific interest in terms of advisory board work and also paid lectures for Lilly; also non-personal specific in terms of research support and meeting attendance support; C.M. Visseren-Grul: Lilly Employee The author declares no conflict of interest; M. Lorenzo: Lilly Employee The author declare...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Lal, R., Summers, Y., Shah, R., Crosse, B., Thompson, J., Nicolson, M. C., Potter, V., Visseren-Grul, C. M., Vikstrom, A., Lorenzo, M., D'Yachkova, Y., Bourayou, N., Hillerdal, G. Tags: NSCLC, metastatic Source Type: research

1327p * a phase i open-label study to evaluate the safety and tolerability of medi4736, an anti-programmed cell death-ligand 1(pd-l1) antibody, in combination with tremelimumab in patients with advanced non-small cell lung cancer (nsclc)
Conclusions: The current safety profile and early anti-tumor activity of M + T supports continued clinical assessment.Disclosure: S.J. Antonia: Honoraria from BMS and MedImmune/Astra Zeneca for work related to designing, implementing, and analyzing various clinical trials. MedImmune considers the research funding received for the conduct of a MedImmune-sponsored study as conflict of interest; S. Goldberg: I have received research funding from MedImmune and AstraZeneca. MedImmune considers the research funding received for the conduct of a MedImmune-sponsored study as conflict of interest; A. Balmanoukian: Research/clinical...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Antonia, S. J., Goldberg, S., Balmanoukian, A., Narwal, R., Robbins, P. B., D'Angelo, G., Blake-Haskins, A., Karakunnel, J. J., Rizvi, N. Tags: NSCLC, metastatic Source Type: research

1352p * active palliation and new treatment strategies for malignant ascites using km-cart
Conclusion: The KM-CART system was considered easy to use and very safe, and the recovery of large volumes of autologous proteins was thought to have improved general status, nutrition, and immune status, as well as subjective symptoms. In addition, the recovered cancer cells were able to be used for drug sensitivity tests and immune cell therapy, indicating the potential for new treatment strategies for malignant ascites in the future.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Matsusaki, K., Tsujitani, S., Yoshizawa, A., Ohta, K. Tags: palliative care Source Type: research

1485pd * outpatient management of cancer-related pulmonary embolism: a propensity score-matched analysis of 803 patients from the epiphany study
Conclusions: Outpatient management of low-risk cancer-related PE appears to be safe and effective. A randomized trial is needed to confirm these data and assess outcomes in specific subgroups.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Carmona-Bayonas, A., Biosca, M., Puig, C. F., Faez, L., Solis Hernandez, M. D. P., Jimenez Fonseca, P., Antonio Rebollo, M., De La Haba, I., Castanon Alvarez, E., Beato, C., Ramchandani, A., Vicente Conesa, M. A., Madridano, O., Otero, R. Tags: supportive care Source Type: research

1511p * sompas: a prospective, non-interventional study (nis) of the management of symptomatic chemotherapy (ct)-induced anemia (cia) in patients (pts) with colorectal (crc), breast (bc) or lung cancer (lc) in austria (at) and switzerland (ch)
Conclusions: ESAs were used as per EORTC guidelines in 71% of pts, 51% of pts were initiated at Hb >10g/dL. Pts achieved a significant increase in Hb during ESA treatment; 90% had a Hb >10 g/dL. A large proportion of pts avoided RBCTs while treated with an ESA.Disclosure: G. Delmore: declares to be a member of the Amgen advisory board; C. Jaeger, C. Bast and I. Pezzani: declares to be an Amgen employee and to hold Amgen stock; M. Schmid: declares to be a member of the Amgen advisory board. All other authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Eisterer, W., Trojan, A., Galid, A., Haslbauer, F., Delmore, G., Kolb, R., Jaeger, C., Bast, C., Pezzani, I., Schmid, M. Tags: supportive care Source Type: research