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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Detection and monitoring of localized matrix metalloproteinase upregulation in a murine model of asthma
We report the application of MMP-2/9 activatable cell-penetrating peptides (ACPPs) and their ratiometric analogs (RACPPs) for in vivo measurement of protease activity and distribution in the lungs of mice that were challenged with the allergen ovalbumin. MMP-2/9 activity was increased greater than twofold in whole, dissected lungs from acutely challenged mice compared with control mice (P = 1.8 x 10–4). This upregulation of MMP-2/9 activity was localized around inflamed airways with 1.6-fold higher protease-dependent ACPP uptake surrounding diseased airways compared with adjacent, pathologically normal lung parenchym...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Felsen, C. N., Savariar, E. N., Whitney, M., Tsien, R. Y. Tags: ARTICLES Source Type: research

Lung endothelial barrier disruption in Lyl1-deficient mice
In this study, we show that LYL1 is also required during the formation of the mature endothelial barrier in the lungs of adult mice. Specifically, LYL1 knockdown in human endothelial cells downregulated the expression of ARHGAP21 and ARHGAP24, which encode two Rho GTPase-activating proteins, and this was correlated with increased RhoA activity and reorganization of the actin cytoskeleton into stress fibers. Importantly, in lungs of Lyl1-deficient mice, both vascular endothelial (VE)-cadherin and p120-catenin were poorly recruited to endothelial adherens junctions, indicative of defective cell-cell junctions. Consistent wit...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Pirot, N., Delpech, H., Deleuze, V., Dohet, C., Courtade-Saidi, M., Basset-Leobon, C., Chalhoub, E., Mathieu, D., Pinet, V. Tags: ARTICLES Source Type: research

Activated alveolar epithelial cells initiate fibrosis through autocrine and paracrine secretion of connective tissue growth factor
Fibrogenesis involves a pathological accumulation of activated fibroblasts and extensive matrix remodeling. Profibrotic cytokines, such as TGF-β, stimulate fibroblasts to overexpress fibrotic matrix proteins and induce further expression of profibrotic cytokines, resulting in progressive fibrosis. Connective tissue growth factor (CTGF) is a profibrotic cytokine that is indicative of fibroblast activation. Epithelial cells are abundant in the normal lung, but their contribution to fibrogenesis remains poorly defined. Profibrotic cytokines may activate epithelial cells with protein expression and functions that overlap ...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Yang, J., Velikoff, M., Canalis, E., Horowitz, J. C., Kim, K. K. Tags: ARTICLES Source Type: research

IL-1{beta} induction of MUC5AC gene expression is mediated by CREB and NF-{kappa}B and repressed by dexamethasone
Chronic airway diseases are characterized by inflammation and mucus overproduction. The MUC5AC mucin gene is upregulated by the proinflammatory cytokine interleukin-1 β (IL-1β) via activation of cAMP response element-binding protein (CREB) in the NCI-H292 cancer cell line and nuclear factor-B (NF-B) in the HBE1 transformed cell line, with each transcription factor binding to a cognate cis site in the proximal or distal region, respectively, of the MUC5AC promoter. We utilized primary differentiated human bronchial epithelial (HBE) and A549 lung adenocarcinoma cells to further investigate the contributions of CREB...
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Authors: Chen, Y., Garvin, L. M., Nickola, T. J., Watson, A. M., Colberg-Poley, A. M., Rose, M. C. Tags: ARTICLES Source Type: research

Corrigendum
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - April 15, 2014 Category: Respiratory Medicine Tags: CORRIGENDA Source Type: research

Association of serum Clara cell protein CC16 with respiratory infections and immune response to respiratory pathogens in elite athletes
Conclusions: Regular high-load exercise is associated with decrease in serum CC16 levels. Athletes with decreased CC16 are more susceptible to respiratory infections. Atopy may be an additional factor modifying susceptibility to infections in subjects performing regular high-load exercise. (Source: Respiratory Research)
Source: Respiratory Research - April 15, 2014 Category: Respiratory Medicine Authors: Marcin KurowskiJanusz JurczykMarzanna Jarz¿bskaSylwia MoskwaJoanna MakowskaHubert KrysztofiakMarek Kowalski Source Type: research

Endoscopic treatment of native lung hyperinflation using endobronchial valves in single‐lung transplant patients: a multinational experience
ConclusionsTreating NLH with IBV endobronchial valves leads to clinical improvement in the majority of patients, and the treatment has an acceptable safety. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - April 15, 2014 Category: Respiratory Medicine Authors: Michael Perch, Gerdt C. Riise, Kyle Hogarth, Ali I. Musani, Steven C. Springmeyer, Xavier Gonzalez, Martin Iversen Tags: Original Article Source Type: research

Influence of oxidative stress, diaphragm fatigue, and inspiratory muscle training on the plasma cytokine response to maximum sustainable voluntary ventilation
In conclusion, increases in plasma IL-1β and IL-6 concentrations during MSVV were not due to diaphragm fatigue or DNA damage in PBMC. Increases in plasma IL-6 concentration during MSVV are attenuated following IMT, and the plasma IL-6 response is dependent upon the level of respiratory muscle work and minute ventilation. (Source: Journal of Applied Physiology)
Source: Journal of Applied Physiology - April 15, 2014 Category: Physiology Authors: Mills, D. E., Johnson, M. A., McPhilimey, M. J., Williams, N. C., Gonzalez, J. T., Barnett, Y. A., Sharpe, G. R. Tags: ARTICLES Source Type: research

Tracheal occlusion-evoked respiratory load compensation and inhibitory neurotransmitter expression in rats
Respiratory load compensation is a sensory-motor reflex generated in the brain stem respiratory neural network. The nucleus of the solitary tract (NTS) is thought to be the primary structure to process the respiratory load-related afferent activity and contribute to the modification of the breathing pattern by sending efferent projections to other structures in the brain stem respiratory neural network. The sensory pathway and motor responses of respiratory load compensation have been studied extensively; however, the mechanism of neurogenesis of load compensation is still unknown. A variety of studies has shown that inhib...
Source: Journal of Applied Physiology - April 15, 2014 Category: Physiology Authors: Tsai, H.-W., Davenport, P. W. Tags: ARTICLES Source Type: research

Cachectic skeletal muscle response to a novel bout of low-frequency stimulation
While exercise benefits have been well documented in patients with chronic diseases, the mechanistic understanding of cachectic muscle's response to contraction is essentially unknown. We previously demonstrated that treadmill exercise training attenuates the initiation of cancer cachexia and the development of metabolic syndrome symptoms (Puppa MJ, White JP, Velazquez KT, Baltgalvis KA, Sato S, Baynes JW, Carson JA. J Cachexia Sarcopenia Muscle 3: 117–137, 2012). However, cachectic muscle's metabolic signaling response to a novel, acute bout of low-frequency contraction has not been determined. The purpose of this s...
Source: Journal of Applied Physiology - April 15, 2014 Category: Physiology Authors: Puppa, M. J., Murphy, E. A., Fayad, R., Hand, G. A., Carson, J. A. Tags: ARTICLES Source Type: research

Primary ciliary dyskinesia diagnosed on nasal mucosal biopsy in two newborns
We report early diagnosis of PCD on nasal mucosal biopsy in two newborns who presented with prolonged respiratory distress and rhinorrhea. (Source: Pediatrics International)
Source: Pediatrics International - April 15, 2014 Category: Pediatrics Authors: Jun Yasuhara, Yuji Yamada, Kaori Hara, Rieko Suhara, Yujiro Hattori, Tetsuji Yamaguchi, Yusuke Mizuno, Rika Kizu, Masahiro Bamba Tags: Patient Reports Source Type: research

Treatment of Bronchopulmonary Dyplasia (BPD).
Authors: PMID: 24735043 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

A unique presentation of a rare congenital anomaly. Double scimitar veins.
PMID: 24735042 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Halabi N, Koirala A, Baldovino B, Smith PR Tags: Am J Respir Crit Care Med Source Type: research

Ventilatory long-term facilitation in humans.
PMID: 24735041 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Tester NJ, Fuller DD, Mateika JH Tags: Am J Respir Crit Care Med Source Type: research

Reply: antioxidants in the intensive care unit.
PMID: 24735040 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Jain M, Chandel NS Tags: Am J Respir Crit Care Med Source Type: research

Classification of the idiopathic interstitial pneumonias.
PMID: 24735039 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Corrin B Tags: Am J Respir Crit Care Med Source Type: research

Antioxidants in the intensive care unit.
PMID: 24735038 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Fisher AB, Forman HJ Tags: Am J Respir Crit Care Med Source Type: research

Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.
PMID: 24735037 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV Tags: Am J Respir Crit Care Med Source Type: research

A Novel Predictor of Cancer Malignancy: Up-regulation of Myristoylated Alanine-Rich C Kinase Substrate Phosphorylation in Lung Cancer.
PMID: 24735036 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Chen CH, Chiu CL, Adler KB, Wu R Tags: Am J Respir Crit Care Med Source Type: research

Heterogeneity in the definition of mechanical ventilation duration and ventilator-free days.
PMID: 24735035 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Contentin L, Ehrmann S, Giraudeau B Tags: Am J Respir Crit Care Med Source Type: research

Beyond removal of endobronchial foreign body.
PMID: 24735034 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Ling Hsu AA, Pena Takano AM, Wai Chan AK Tags: Am J Respir Crit Care Med Source Type: research

Lung cancer screening, targeted temperature after cardiac arrest, and vasopressin and steroids in cardiac arrest.
PMID: 24735033 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Y Hwang J, F Arredondo A, Paul TK Tags: Am J Respir Crit Care Med Source Type: research

Official american thoracic society technical standards: spirometry in the occupational setting.
Conclusions: Important aspects of workplace spirometry are discussed and recommendations are provided for the performance and interpretation of workplace spirometry. PMID: 24735032 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Redlich CA, Tarlo SM, Hankinson JL, Townsend MC, Eschenbacher WL, Von Essen SG, Sigsgaard T, Weissman DN, American Thoracic Society Committee on Spirometry in the Occupational Setting Tags: Am J Respir Crit Care Med Source Type: research

Update in tuberculosis and nontuberculous mycobacterial infections 2013.
PMID: 24735031 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Reves R, Schluger NW Tags: Am J Respir Crit Care Med Source Type: research

Seeing is believing: imaging early lung disease in cystic fibrosis.
PMID: 24735030 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Alexiou S, Rubenstein RC Tags: Am J Respir Crit Care Med Source Type: research

Ventilator-associated Complications, Ventilator-associated Pneumonia, and Newton's Third Law of Mechanics.
PMID: 24735029 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Wunderink RG Tags: Am J Respir Crit Care Med Source Type: research

Novel biomarkers to anticipate acute kidney injury. Getting ahead of the curve.
PMID: 24735028 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Bagshaw SM Tags: Am J Respir Crit Care Med Source Type: research

Oxidant-mediated Aggregation of Z α1-Antitrypsin in Pulmonary Epithelial Cells Amplifies Lung Inflammation.
PMID: 24735027 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Blanco I Tags: Am J Respir Crit Care Med Source Type: research

Understanding and improving clinical trial outcome measures in acute respiratory failure.
PMID: 24735026 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Needham DM Tags: Am J Respir Crit Care Med Source Type: research