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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Antimicrobial susceptibility profiles of Staphylococcus aureus isolates classified according to their origin in a tertiary hospital in Korea
Publication date: Available online 16 October 2014 Source:American Journal of Infection Control Author(s): Hee-Won Moon , Hyun Jung Kim , Mina Hur , Yeo-Min Yun We performed a comprehensive analysis on 3,594 Staphylococcus aureus isolates from routine culture during the last 4 years. The antimicrobial susceptibilities of the isolates were analyzed according to their origin and were compared based on the type of specimens. The proportion of methicillin-resistant Staphylococcus aureus (MRSA) in community-associated (CA), health care–associated, community onset (HACO), and health care–associated (HA) isolates were 33.0...
Source: American Journal of Infection Control - October 26, 2014 Category: Infectious Diseases Source Type: research

N95 respirator use during advanced pregnancy
Conclusions Healthy pregnant women wearing an N95 FFR for 1 hour during exercise and sedentary activities did not exhibit any significant differences in measured physiological and subjective responses compared with nonpregnant women. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - October 26, 2014 Category: Infectious Diseases Source Type: research

Subglottic secretion drainage and continuous control of cuff pressure used together save health care costs
Conclusions The combined use of SSD and CCCP reduced the incidence of VARI and saved health care costs. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - October 26, 2014 Category: Infectious Diseases Source Type: research

Negative pressure wound therapy facilitates closure of large congenital abdominal wall defects
Abstract The degree of viscero-abdominal disproportion often makes single-stage reduction difficult in large abdominal wall defects, without risking respiratory or hemodynamic compromise. As a consequence, clinicians have adopted a number of different methods to control these defects. Repair may be in the neonatal period, or later in life. Delayed repairs require epithelialization of the gastroschisis or omphalocele. Definitive repair may be in single or multiple stages. This paper describes four children in whom negative pressure wound therapy (NPWT) was used to facilitate closure of these complex defects. (Sour...
Source: Pediatric Surgery International - October 25, 2014 Category: Surgery Source Type: research

50 Years Ago in The Journal of Pediatrics: A 5-Year Clinical Evaluation of Therapeutic Program for Patients with Cystic Fibrosis
This article, along with companion publications published in other issues of The Journal, outlined a therapeutic program for children with cystic fibrosis (CF) and its effects on survival, as developed by researchers at Western Reserve University in Cleveland, Ohio. Prior to these studies, CF had a reported mortality of 5%-15% per year, with most children dying before adulthood of respiratory failure. By 1964, the pathophysiology of CF had been accurately defined: the secretions of the exocrine glands were abnormally viscous, leading to blocked airways, chronic infection and inflammation, bronchiectasis, and pulmonary fibr...
Source: The Journal of Pediatrics - October 25, 2014 Category: Pediatrics Authors: Philip Toltzis Tags: Original Articles Source Type: research

Kingella kingae, a surprising and stealthy osteoarticular pathogen
Kingella kingae has gained a conspicuous place in the roster of pathogens of osteoarticular infections in young children. In many countries K kingae is the most common etiology of joint infections in children 6 to 48 months of age. Known to colonize the upper respiratory tract and transmit readily in children in daycare, the role of K kingae's in osteoarticular infections frequently is only confirmed by special care to inoculate tissue and fluid specimens into liquid media or through molecular diagnostic testing. (Source: The Journal of Pediatrics)
Source: The Journal of Pediatrics - October 25, 2014 Category: Pediatrics Authors: Sarah S. Long Tags: The Editors' Perspectives Source Type: research

Cystic Fibrosis Transmembrane Conductance Regulator Protein (CFTR) Expression in the Developing Human Brain: Comparative Immunohistochemical Study between Patients with Normal and Mutated CFTR
Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein has recently been shown to be expressed in the human adult central nervous system (CNS). As CFTR expression has also been documented during embryonic development in several organs, such as the respiratory tract, the intestine and the male reproductive system, suggesting a possible role during development we decided to investigate the expression of CFTR in the human developing CNS. In addition, as some, although rare, neurological symptoms have been reported in patients with CF, we compared the expression of normal and mutated CFTR at several fetal stages. I...
Source: Journal of Histochemistry and Cytochemistry - October 25, 2014 Category: Biochemistry Authors: Marcorelles, P., Friocourt, G., Uguen, A., Lede, F., Ferec, C., Laquerriere, A. Tags: Articles Source Type: research

Integrating Evolutionary and Functional Tests of Adaptive Hypotheses: A Case Study of Altitudinal Differentiation in Hemoglobin Function in an Andean Sparrow, Zonotrichia capensis
In air-breathing vertebrates, the physiologically optimal blood-O2 affinity is jointly determined by the prevailing partial pressure of atmospheric O2, the efficacy of pulmonary O2 transfer, and internal metabolic demands. Consequently, genetic variation in the oxygenation properties of hemoglobin (Hb) may be subject to spatially varying selection in species with broad elevational distributions. Here we report the results of a combined functional and evolutionary analysis of Hb polymorphism in the rufous-collared sparrow (Zonotrichia capensis), a species that is continuously distributed across a steep elevational gradient ...
Source: Molecular Biology and Evolution - October 25, 2014 Category: Molecular Biology Authors: Cheviron, Z. A., Natarajan, C., Projecto-Garcia, J., Eddy, D. K., Jones, J., Carling, M. D., Witt, C. C., Moriyama, H., Weber, R. E., Fago, A., Storz, J. F. Tags: Discoveries Source Type: research

Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways
Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 25, 2014 Category: Respiratory Medicine Authors: Angelica Brandelius, Morgan Andersson, Lena Uller Tags: Short Communication Source Type: research

Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing
Improved detection of fungi in clinical samples allows the characterization of fungi in the human airway (Source: Genome Biology)
Source: Genome Biology - October 25, 2014 Category: Genetics & Stem Cells Authors: Kyle BittingerEmily CharlsonElizabeth LoyDavid ShirleyAndrew HaasAlice LaughlinYanjie YiGary WuJames LewisIan FrankEdward CantuJoshua DiamondJason ChristieRonald CollmanFrederic Bushman Source Type: research

Shoot chloride exclusion and salt tolerance in grapevine is associated with differential ion transporter expression in roots
Conclusions: These results demonstrate that transcriptional events contributing to the Cl? exclusion mechanism in grapevine are not stress-inducible, but constitutively different between contrasting varieties. We have identified individual genes from large families known to have members with roles in anion transport in other plants, as likely candidates for controlling anion homeostasis and Cl? exclusion in Vitis species. We propose these genes as priority candidates for functional characterisation to determine their role in chloride transport in grapevine and other plants. (Source: BMC Plant Biology)
Source: BMC Plant Biology - October 25, 2014 Category: Biology Authors: Sam HendersonUte BaumannDeidre BlackmoreAmanda WalkerRob WalkerMatthew Gilliham Source Type: research

Deinococcus enclensis sp. nov., isolated from a marine sediment sample.
Abstract A novel pale-pink coloured strain, designated NIO-1023(T), was isolated from a marine sediment sample from Chorao Island, Goa, India. The taxonomic position of strain NIO-1023(T) was investigated by using a polyphasic approach. The cells were observed to be Gram-stain positive, coccal shaped and non-spore forming. Phylogenetic analyses using the 16S rRNA gene sequence of the isolate indicated that the organism belongs to the genus Deinococcus. The strain NIO-1023(T) showed highest 16S rRNA gene sequence similarities with Deinococcus ficus (97.8 %), whereas other Deinococcus species showed less than 95 % ...
Source: Antonie van Leeuwenhoek - October 25, 2014 Category: Microbiology Authors: Thorat MN, Mawlankar R, Sonalkar VV, Venkata Ramana V, Joseph N, Shouche YS, Dastager SG Tags: Antonie Van Leeuwenhoek Source Type: research

Telomerase gene mutations and telomere length shortening in patients with idiopathic pulmonary fibrosis in a Chinese population
ConclusionsSix novel mutations in the telomerase genes were identified for the first time in individuals diagnosed with sporadic IPF in a Chinese Han population. Shorter telomeres and mild thrombocytopaenia could be clues to association with telomerase gene mutation and sporadic IPF. (Source: Respirology)
Source: Respirology - October 24, 2014 Category: Respiratory Medicine Authors: Jinghong Dai, Hourong Cai, Yi Zhuang, Yongzheng Wu, Haiyan Min, Jinheng Li, Yi Shi, Qian Gao, Long Yi Tags: Original Article Source Type: research

Qualitative and Quantitative Assessment of Smoking-related Lung Disease: Effect of Iterative Reconstruction on Low-dose Computed Tomographic Examinations
Purpose:The purpose of this research is to examine the role that differing levels of adaptive statistical iterative reconstruction (ASIR) have on the qualitative and quantitative assessment of smoking-related lung disease. Materials and Methods:Institutional board review approval was obtained. A total of 52 patients undergoing clinically indicated low-dose computed tomographic (CT) examinations of the chest (100 kVp, 65 mAs, mean radiation dose 1.0±0.12 mSv), with reconstruction of data with different levels of blended ASIR (0%, 40%, and 100%), were consented. Qualitative assessment of CT data sets was performed by 2 trai...
Source: Journal of Thoracic Imaging - October 24, 2014 Category: Radiology Tags: Original Articles Source Type: research

Vitamin D Deficiency and Acute Lower Respiratory Infections in Children Younger Than 5 Years: Identification and Treatment
Acute lower respiratory infection (ALRI) is a leading cause of childhood mortality. Research suggests that vitamin D deficiency (VDD) puts children at risk for ALRI. The purpose of this review is to examine ALRI and VDD in children 5 years and younger. Common etiologies, diagnosis, prevention, treatment of ALRI, and recommendations for vitamin D supplementation are summarized. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - October 24, 2014 Category: Pediatrics Authors: Allison Larkin, Jane Lassetter Tags: Department Source Type: research

A Comparison of Antibiotic Serum Concentrations Drawn from Peripherally Inserted Central Catheter versus Peripheral Vein in Children with Respiratory Infection
To evaluate serum concentration of antibiotics drawn from a peripherally inserted central catheter (PICC) compared to serum concentration of antibiotic levels drawn from a venipuncture. (Source: Journal of Pediatric Health Care)
Source: Journal of Pediatric Health Care - October 24, 2014 Category: Pediatrics Authors: Keri Jean Sullivan, MaryEllen Green, Sarah Wells Tags: 2014 Poster Award Winners and Presentation Abstract Source Type: research

GE CareScape Respiratory Modules
No abstract available (Source: Biomedical Safety and Standards)
Source: Biomedical Safety and Standards - October 24, 2014 Category: Medical Equipment Tags: Recalls & Field Corrections-Class II Source Type: research

Impact of Hypertriglyceridemia on the Outcome of Acute Biliary Pancreatitis
Conclusions:High TG level (≥2.26 mmol/L or 200.11 mg/mL) may be a risk factor for severe ABP and the development of systemic and local complications in ABP. (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - October 24, 2014 Category: Journals (General) Tags: Clinical Investigation Source Type: research

Two Cases Of Neonatal Human Parechovirus 3 Encephalitis
We report 2 neonates with human parechoviruses type 3 encephalitis. Both newborns presented with fever, irritability and seizures. Cerebrospinal fluid analyses were normal, but magnetic resonance imaging revealed white matter damage, suggesting human parechoviruse infection. Human parechoviruses type 3-RNA was detected in cerebrospinal fluid samples and in blood, stool, urine and respiratory samples, indicating the dissemination of the virus. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 24, 2014 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Palivizumab Use In Japanese Infants And Children With Immunocompromised Conditions
A total of 27/28 (96%) immunocompromised Japanese children received ≥4 doses of palivizumab. No respiratory syncytial virus-associated hospitalizations occurred. Mean palivizumab trough concentrations were 59.0 and 91.8 μg/mL 30 days after the 1st and 4th doses, respectively. Of 28 subjects, 27 (96%) experienced ≥1 adverse event and 7 (25%) experienced ≥1 serious adverse event, none of which was considered related to palivizumab. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - October 24, 2014 Category: Infectious Diseases Tags: Brief Reports Source Type: research

Human Parechovirus Type 3 and 4 Associated With Severe Infections in Young Children
In this study, we examined the connection between HPeV and acute otitis media, lower respiratory infections and suspected central nervous system infections. Methods:An HPeV specific real-time reverese transcriptase polymerase chain reaction was used to detect HPeV RNA. We analyzed altogether 200 middle-ear fluid samples, 192 nasopharyngeal aspirates, 79 cerebrospinal fluid specimens and 50 serum and 5 fecal or fecal culture samples. Positive samples were typed by sequencing the VP1 region. Results:Seven (8%) of 85 children with suspected central nervous system infections were positive for HPeV. Of these, 4 (all in autumn 2...
Source: The Pediatric Infectious Disease Journal - October 24, 2014 Category: Infectious Diseases Tags: Original Studies Source Type: research

Inter-society consensus document on treatment and prevention of bronchiolitis in newborns and infants
Acute bronchiolitis is the leading cause of lower respiratory tract infection and hospitalization in children less than 1 year of age worldwide. It is usually a mild disease, but some children may develop severe symptoms, requiring hospital admission and ventilatory support in the ICU. Infants with pre-existing risk factors (prematurity, bronchopulmonary dysplasia, congenital heart diseases and immunodeficiency) may be predisposed to a severe form of the disease.Clinical diagnosis of bronchiolitis is manly based on medical history and physical examination (rhinorrhea, cough, crackles, wheezing and signs of respiratory dis...
Source: Italian Journal of Pediatrics - October 24, 2014 Category: Pediatrics Authors: Eugenio BaraldiMarcello LanariPaolo ManzoniGiovanni RossiSilvia VandiniAlessandro RiminiCostantino RomagnoliPierluigi ColonnaAndrea BiondiPaolo BibanGiampietro ChiamentiRoberto BernardiniMarina PiccaMarco CappaGiuseppe MagazzùCarlo CatassiAntonio UrbinoL Source Type: research

Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus
Conclusions: Non-emphysematous COPD, defined by airflow obstruction with a paucity of emphysema on chest CT scan, is associated with an increased risk of diabetes. COPD patients without emphysema may warrant closer monitoring for diabetes, hypertension, and hyperlipidemia and vice versa.Trial registration: Clinicaltrials.gov identifiers: COPDGene NCT00608764, ECLIPSE NCT00292552. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 24, 2014 Category: Respiratory Medicine Authors: Craig HershBarry MakeDavid LynchR BarrRussell BowlerPeter CalverleyPeter CastaldiMichael ChoHarvey CoxsonDawn DeMeoMarilyn ForemanMeiLan HanBenjamin HarshfieldJohn HokansonSharon LutzJoe RamsdellElizabeth ReganStephen RennardJoyce SchroederFrank SciurbaRo Source Type: research

Mitochondrial Cytochrome P450 2C8 [Membrane Biology]
This study suggests that mitochondrially targeted variant 3 CYP2C8 may contribute to oxidative stress in various tissues. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - October 24, 2014 Category: Chemistry Authors: Bajpai, P., Srinivasan, S., Ghosh, J., Nagy, L. D., Wei, S., Guengerich, F. P., Avadhani, N. G. Tags: Metabolism Source Type: research

Thoracic epidural anaesthesia for awake thoracic surgery in severely dyspnoeic patients excluded from general anaesthesia
CONCLUSIONS TEATS with/without sedation was an alternative to GA for thoracotomy/thoracoscopy in severely dyspnoeic patients (MMRC grade 4, ASA 4) without postoperative sequelae. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - October 24, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Kiss, G., Claret, A., Desbordes, J., Porte, H. Tags: Anesthesia, Pleura Thoracic Source Type: research

Non‐clinical interventions for acute respiratory infections and diarrheal diseases among young children in developing countries
ConclusionPublic investment in sanitation and hygiene, water supply and quality, and the provision of medical equipment that detect symptoms of childhood diseases, in combination of training and education for medical workers, are effective policy strategies to reduce diarrhoeal diseases and acute respiratory infections. More research is needed in the countries that are most affected by childhood diseases. There is a need for disaggregation of analysis by age‐cohorts, as impact effectiveness of policies depends on children's age.This article is protected by copyright. All rights reserved. (Source: Tropical Medicine and International Health)
Source: Tropical Medicine and International Health - October 24, 2014 Category: Tropical Medicine Authors: Miguel Niño Zarazúa, Maureen Seguin Tags: Systematic review Source Type: research

The Nasal and Sinus Microbiome in Health and Disease
Abstract There has been great interest in unraveling the complex inter-relationships between microbes and humans as they relate to human health and disease. This review will focus on recent advances in the appreciation and understanding of these relationships in terms of the upper respiratory tract, specifically the nose and paranasal sinuses. (Source: Current Allergy and Asthma Reports)
Source: Current Allergy and Asthma Reports - October 24, 2014 Category: Allergy & Immunology Source Type: research

Hemodynamic impact of isobaric levobupivacaine versus hyperbaric bupivacaine for subarachnoid anesthesia in patients aged 65 and older undergoing hip surgery
The objective of the study was to determine the exact role of local anesthetic selection underlying spinal anesthesia-induced hypotension in the elderly patient. We conducted a descriptive, observational pilot study to assess the hemodynamic impact of subarachnoid anesthesia with isobaric levobupivacaine versus hyperbaric bupivacaine for hip fracture surgery.Description: Hundred twenty ASA status I-IV patients aged 65 and older undergoing hip fracture surgery were enrolled. The primary objective of our study was to compare hemodynamic effects based on systolic blood pressure (SBP) and dyastolic blood pressure (DBP) values,...
Source: BMC Anesthesiology - October 24, 2014 Category: Anesthesiology Authors: Rosa HerreraJose De AndrésLuis EstañFrancisco OlivasInocencia Martínez-MirThorsten Steinfeldt Source Type: research

The Alexander Technique and musicians: a systematic review of controlled trials
Conclusions: A variety of outcome measures have been used to investigate the effectiveness of AT sessions in musicians. Evidence from RCTs and CTs suggests that AT sessions may improve performance anxiety in musicians. Effects on music performance, respiratory function and posture yet remain inconclusive. Future trials with well-established study designs are warranted to further and more reliably explore the potential of AT in the interest of musicians. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - October 24, 2014 Category: Complementary Medicine Authors: Sabine KleinClaudine BayardUrsula Wolf Source Type: research

Effect of the Pillar implant on snoring and mild obstructive sleep apnea: A multicenter study in Korea
ConclusionsIn selected Korean patients, the Pillar implant significantly improved not only subjective symptoms of mild SDB but also respiratory disturbances in mild OSA. Level of Evidence2b. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - October 24, 2014 Category: ENT & OMF Authors: Ji Ho Choi, Jae Hoon Cho, Yoo‐Sam Chung, Jeong‐Whun Kim, Sung Wan Kim Tags: Sleep Medicine Source Type: research

Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications
Since the first description of Middle East respiratory syndrome coronavirus (MERS-CoV), it has not been known how long patients shed the virus in respiratory secretions. Thus, we analyzed the available data on time to negative MERS-CoV test in patients with confirmed MERS-CoV infection and asymptomatic positive contacts. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 24, 2014 Category: Infectious Diseases Authors: Ziad A. Memish, Abdullah M. Assiri, Jaffar A. Al-Tawfiq Source Type: research

Healthcare-associated respiratory tract infection and colonization in an intensive care unit caused by isolated in mouthwash
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - October 24, 2014 Category: Infectious Diseases Authors: Jeannete Zurita, Lorena Mejia, Sonia Zapata, Gabriel Trueba, Ana Cecilia Vargas, Samanta Aguirre, Guillermo Falconi Source Type: research

Subcutaneous implant with etonogestrel (Implanon(R)) for catamenial exacerbations in a patient with cystic fibrosis: a case report
Conclusion: Our case report supports the key role of female hormones in the development of PE and in the decline of lung function in a woman with CF. When appropriate, hormonal manipulation through contraceptive methods should be considered as potential treatment. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 24, 2014 Category: Respiratory Medicine Authors: Adelaida LamasLuis MáizMarta de ValbuenaJosé González-CasbasLucrecia Suárez Source Type: research

Opportunities for cystic fibrosis care teams to support treatment adherence
The purpose of this study was to identify the extent to which pediatric and adult cystic fibrosis (CF) care teams implement best practices in adherence assessment and counseling. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - October 24, 2014 Category: Respiratory Medicine Authors: Kristin A. Riekert, Michelle N. Eakin, Andrew Bilderback, Alana K. Ridge, Bruce C. Marshall Tags: Original Article Source Type: research

International guidelines for the management and treatment of Morquio A syndrome
Morquio A syndrome (mucopolysaccharidosis IVA) is a lysosomal storage disorder associated with skeletal and joint abnormalities and significant non‐skeletal manifestations including respiratory disease, spinal cord compression, cardiac disease, impaired vision, hearing loss, and dental problems. The clinical presentation, onset, severity and progression rate of clinical manifestations of Morquio A syndrome vary widely between patients. Because of the heterogeneous and progressive nature of the disease, the management of patients with Morquio A syndrome is challenging and requires a multidisciplinary approach, involving a...
Source: American Journal of Medical Genetics Part A - October 24, 2014 Category: Genetics & Stem Cells Authors: Christian J. Hendriksz, Kenneth I. Berger, Roberto Giugliani, Paul Harmatz, Christoph Kampmann, William G. Mackenzie, Julian Raiman, Martha Solano Villarreal, Ravi Savarirayan Tags: Research Review Source Type: research

Trends in licit and illicit drug-related deaths in Florida from 2001 to 2012
Drug misuse imposes significant burdens on societies worldwide, taking a considerable toll on the human lives from overdoses and diseases associated with drug use such as AIDS, hepatitis, and various hepatic, respiratory, and cardiovascular conditions [1]. High prevalence of suicides, accidents, and violent behaviors associated with drug use also contributes to the drug-related fatalities [1–3]. Globally, the drug-related mortality rate is estimated at 40 (range, 20.8-49.3) deaths per million among the population aged 15-64 years [4]. (Source: Forensic Science International)
Source: Forensic Science International - October 24, 2014 Category: Forensic Medicine Authors: Dayong Lee, Chris Delcher, Mildred M. Maldonado-Molina, Lindsay A.L. Bazydlo, Jon R. Thogmartin, Bruce A. Goldberger Source Type: research

A Non-BRICHOS SFTPC Mutant (SP-CI73T) Linked To Interstitial Lung Disease Promotes A Late Block In Macroautophagy Disrupting Cellular Proteostasis and Mitophagy.
Abstract Mutation of threonine for isoleucine at codon 73 (I73T) in the human surfactant protein C (hSP-C) gene (SFTPC) accounts for a significant portion of SFTPC mutations associated with interstitial lung disease (ILD). Cell lines stably expressing tagged proSP-C isoforms were generated to test the hypothesis that deposition of hSP-C(I73T) within the endosomal system promotes disruption of a key cellular quality control pathway, macroautophagy. By fluorescence microscopy, hSP-C(WT) co-localized with exogenously expressed hABCA3, an indicator of normal trafficking to lysosomal related organelles. In contrast, hSP...
Source: Am J Physiol Lung Ce... - October 24, 2014 Category: Respiratory Medicine Authors: Hawkins A, Guttentag SH, Deterding R, Funkhouser WK, Goralski JL, Chatterjee S, Mulugeta S, Beers MF Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Cigarette Smoke Enhances Proliferation and Extracellular Matrix Deposition By Human Fetal Airway Smooth Muscle.
In this study, we used canalicular stage (18-20 weeks gestational age) human fetal airway smooth muscle (fASM) cells as an in vitro model of the immature airway. fASM cells were exposed to cigarette smoke extract (CSE; 0.5-1.5% for 24-72 h) and cell proliferation, ECM deposition, and intracellular calcium ([Ca(2+)]i) responses to agonist (histamine 10 μM) were used to evaluate effects on remodeling and hyperreactivity. CSE significantly increased cell proliferation and deposition of ECM molecules collagen I, collagen III, and fibronectin. In contrast, [Ca(2+)]i responses were not significantly affected by CSE. Analysis of...
Source: Am J Physiol Lung Ce... - October 24, 2014 Category: Respiratory Medicine Authors: Vogel ER, VanOosten SK, Holman MA, Hohbein DD, Thompson MA, Vassallo R, Pandya HC, Prakash YS, Pabelick CM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Subcutaneous implant with etonogestrel (Implanon®) for catamenial exacerbations in a patient with cystic fibrosis: a case report
Conclusion: Our case report supports the key role of female hormones in the development of PE and in the decline of lung function in a woman with CF. When appropriate, hormonal manipulation through contraceptive methods should be considered as potential treatment. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 24, 2014 Category: Respiratory Medicine Authors: Adelaida LamasLuis MáizMarta de ValbuenaJosé González-CasbasLucrecia Suárez Source Type: research

Efficacy and safety of enzyme replacement therapy with BMN 110 (elosulfase alfa) for Morquio A syndrome (mucopolysaccharidosis IVA): a phase 3 randomised placebo-controlled study
Conclusions Elosulfase alfa improved endurance as measured by the 6MWT in the weekly but not qow dose group, did not improve endurance on the 3MSCT, reduced urine KS, and had an acceptable safety profile. (Source: Journal of Inherited Metabolic Disease)
Source: Journal of Inherited Metabolic Disease - October 23, 2014 Category: Internal Medicine Source Type: research

Effectiveness of enzyme replacement therapy in adults with late-onset Pompe disease: results from the NCS-LSD cohort study
Conclusions These data provide some further evidence of the effectiveness of ERT in adults with late-onset Pompe disease. Synopsis The results of this longitudinal cohort study of 62 adults with late-onset Pompe disease, provide further evidence on the effectiveness of ERT in this rare condition. (Source: Journal of Inherited Metabolic Disease)
Source: Journal of Inherited Metabolic Disease - October 23, 2014 Category: Internal Medicine Source Type: research

Chronic respiratory conditions in a cohort of metropolitan fire-fighters: associations with occupational exposure and quality of life
Conclusions Ten percent of metropolitan fire-fighters reported underlying chronic respiratory conditions. Presence of such a condition in combination with suboptimal protection from inhaled exposures may lead to poorer physical HRQoL. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - October 23, 2014 Category: Occupational Health Source Type: research

Exercise training combined with psychological interventions for people with chronic obstructive pulmonary disease
The objective of this systematic review was to examine the effect of interventions which combine exercise training and psychological interventions for a range of health outcomes in people with COPD. Database searches identified randomized controlled trials of people with COPD participating in interventions that combined exercise training with a psychological strategy compared with control (usual care, waiting list) or active comparators (education, exercise, psychological interventions alone). Health outcomes included dyspnoea, anxiety, depression, quality of life or functional exercise capacity. Standardized mean differen...
Source: Respirology - October 23, 2014 Category: Respiratory Medicine Authors: Louise Wiles, Paul Cafarella, Marie T. Williams Tags: Review Source Type: research

CDC Kerala 13: Antenatal, Natal and Postnatal Factors Among Children (2–6 y) with Autism – A Case Control Study
Conclusions This case control study involving 143 children between 2 and 6 y with autism as per CARS criteria and a control group of 200 normal children has shown that excess fetal movement, maternal respiratory infection/asthma, maternal vaginal infection, maternal hypothyroidism and family history of neuro-developmental disorders are possible risk factors for autism. (Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - October 23, 2014 Category: Pediatrics Source Type: research

Outcome for self-expandable metal stents in patients with malignant gastroduodenal obstruction: A single center experience
Conclusion Metallic stent placement is an effective and relatively safe treatment for patients with malignant gastric outlet obstruction. (Source: Advances in Digestive Medicine)
Source: Advances in Digestive Medicine - October 23, 2014 Category: Gastroenterology Source Type: research

Type 2 Diabetes Mellitus: The Concerned Complications and Target Organs
Publication date: September 2014 Source:Apollo Medicine, Volume 11, Issue 3 Author(s): Ashwini Kumar , Sudhanshu Kumar Bharti , Awanish Kumar Diabetes has been considered as the most dreaded non-communicable disease consuming the mankind rapidly. WHO has predicted the number of diabetics to be approximately 366 millions by 2030. The disease is characterized by hyperglycemia and the basic symptoms are polyphagia, polydipsia and polyuria. The autoimmune type 1 diabetes represent almost 1% of the total diabetic population, the rest being that of type 2 diabetes (T2D). Type 2 diabetes has been linked to a variety of factors ...
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research

Guillain–Barré syndrome after acute myocardial infarction: A rare presentation
We report such a rare association of acute myocardial infarction and Guillain–Barré syndrome. Our patient underwent primary angioplasty successfully, but developed respiratory failure while in hospital. While the difficulty in weaning off from ventilator a suspicion of neuromuscular disease was made. The further investigations, including nerve conduction study confirmed a diagnosis of Guillain–Barré syndrome. Despite treatment, the patient died secondary to multi-organ dysfunction. Our case is 4th reported in the literature without use of any thrombolytic agent for such association. (Source: Apollo Medicine)
Source: Apollo Medicine - October 23, 2014 Category: Journals (General) Source Type: research

Exposure of mice to secondhand smoke elicits both transient and long‐lasting transcriptional changes in cancer‐related functional networks
ABSTRACT Secondhand smoke (SHS) has long been linked to lung cancer and other diseases in nonsmokers. Yet, the underlying mechanisms of SHS carcinogenicity in nonsmokers’ lung cancer remain to be elucidated. We investigated the immediate and long‐lasting effects of SHS exposure on gene expression in mice in vivo. We exposed mice whole body to SHS for 5 hours/day, 5 days/week for 4 months in exposure chambers of a microprocessor‐controlled smoking machine. Subsequently, we performed microarray gene expression profiling, genome‐wide, to construct the pulmonary transcriptome of SHS‐exposed mice, immediately after di...
Source: International Journal of Cancer - October 23, 2014 Category: Cancer & Oncology Authors: Stella Tommasi, Albert Zheng, Ahmad Besaratinia Tags: Carcinogenesis Source Type: research