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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Low-Dose Clarithromycin Therapy Modulates Th17 Response In Non-Cystic Fibrosis Bronchiectasis Patients
Conclusions Our results argue for a reduction of both systemic and local Th17 response after prophylactic, low-dose clarithromycin administration in patients with non-CF bronchiectasis, suggestive of a potential anti-inflammatory and/or immunomodulatory action. (Source: Lung)
Source: Lung - November 20, 2014 Category: Respiratory Medicine Source Type: research

Association Analysis of Melanocortin 3 Receptor Polymorphisms with the Risk of Pulmonary Tuberculosis
Conclusions The C allele of rs11575886 could be a risk allele for the pulmonary TB by affecting the binding of TF. Our findings suggest that polymorphisms in MC3R might be one of genetic factors for the risk of pulmonary TB development in Korean subjects. (Source: Lung)
Source: Lung - November 20, 2014 Category: Respiratory Medicine Source Type: research

Atopy as a risk factor for the development of asthma in young recruits
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - November 20, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Vocal cord dysfunction in bronchial asthma. A review article
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - November 20, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Design of parallel transmission radiofrequency pulses robust against respiration in cardiac MRI at 7 Tesla
ConclusionA new pTX RF pulse design robust against respiration induced variations of B1+/B0 maps is demonstrated and is expected to have a positive impact on cardiac MRI in breath‐hold, free‐breathing, and real‐time acquisitions. Magn Reson Med, 2014. © 2014 Wiley Periodicals, Inc. (Source: Magnetic Resonance in Medicine)
Source: Magnetic Resonance in Medicine - November 20, 2014 Category: Radiology Authors: Sebastian Schmitter, Xiaoping Wu, Kâmil Uğurbil, Pierre‐François Van de Moortele Tags: Full paper Source Type: research

Current options in the treatment of mitochondrial diseases.
Authors: Scarpelli M, Cotelli MS, Mancuso M, Tomelleri G, Tonin P, Baronchelli C, Vielmi V, Gregorelli V, Todeschini A, Padovani A, Filosto M Abstract Mitochondrial diseases (MD) are disorders caused by an impairment of the mitochondrial respiratory chain function. They are usually progressive, isolated or multi-system diseases and have variable times of onset. Because mitochondria have their own DNA (mtDNA), MD can be caused by mutations in both mtDNA and nuclear DNA (nDNA). The complexity of genetic control of mitochondrial function is in part responsible for the intra- and inter-familiar clinical heterogeneity o...
Source: Recent Patents on CNS Drug Discovery - November 20, 2014 Category: Drugs & Pharmacology Tags: Recent Pat CNS Drug Discov Source Type: research

The utility of polysomnography for the diagnosis of NREM parasomnias: an observational study over 4 years of clinical practice
Abstract Polysomnography (PSG) is considered the gold standard for diagnosis of non-rapid eye movement (NREM) parasomnias, however its diagnostic yield has been rarely reported. We aimed to assess the diagnostic value of polysomnography in different categories of patients with suspected NREM parasomnia and define variables that can affect the outcome. 124 adults referred for polysomnography for suspected NREM parasomnia were retrospectively identified and divided into clinical categories based on their history. Each polysomnography was analysed for features of NREM parasomnia or different sleep disorders and for p...
Source: Journal of Neurology - November 20, 2014 Category: Neurology Source Type: research

Contribution of respiratory tract infections to child deaths: a data linkage study
Conclusions: RTI-related deaths have not declined in the last decade except in infants. Targeted strategies to prevent the winter excess of RTIs and to treat RTIs in children, particularly children with chronic conditions, may reduce RTI-related deaths. (Source: BMC Public Health)
Source: BMC Public Health - November 20, 2014 Category: Consumer Health News Authors: Pia HardelidNirupa DattaniMario Cortina-BorjaRuth Gilbert Source Type: research

Respirophasic Forward Diastolic Flow through the Pulmonary Valve in Massive Right Ventricular Infarction
We report a case illustrating Fontan physiology in massive right ventricular infarction. The infarcted right ventricle acted as a passive conduit between the right atrium and the pulmonary artery, and the flow was largely driven by respiratory variations in intrathoracic pressure. During inspiration, the pulmonary valve remained open throughout the whole cardiac cycle and the right ventricular outflow was almost entirely antegrade both in systole and diastole. (Source: Echocardiography)
Source: Echocardiography - November 20, 2014 Category: Cardiology Authors: Alberto Bouzas‐Mosquera, Beatriz Bouzas‐Zubeldía, Jesús Peteiro, Nemesio Álvarez‐García Tags: Image Section Source Type: research

Longitudinal increase in total IgE levels in patients with adult asthma: an association with poor asthma control
Conclusions: These data suggest that a longitudinal increase in total IgE is associated with both poor asthma control and Aspergillus-specific IgE in patients with adult asthma. (Source: Respiratory Research)
Source: Respiratory Research - November 20, 2014 Category: Respiratory Medicine Authors: Akihiko TanakaMegumi JinnoKuniaki HiraiYoshito MiyataHiroko MizumaMunehiro YamaguchiShin OhtaYoshio WatanabeMayumi YamamotoShintaro SuzukiTakuya YokoeMitsuru AdachiHironori Sagara Source Type: research

A new era of drug therapy for idiopathic pulmonary fibrosis
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Michael G Crooks , Simon P Hart (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Is COPD in its age of enlightenment?
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Christine Jenkins (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

ALK and ROS1 non-small-cell lung cancer: two molecular subgroups sensitive to targeted therapy
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Rafael Rosell , Niki Karachaliou , Juergen Wolf , Sai-Hong Ignatius Ou (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Emerging respiratory infections: influenza, MERS-CoV, and extensively drug-resistant tuberculosis
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Andrew Hayward , Ellen Fragaszy (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Non-cystic fibrosis bronchiectasis: an evidence-base for new therapies
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Diana Bilton , Michael R Loebinger , Robert Wilson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

The challenges of trials of antibiotics for pneumonia in low–income countries
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Kim Mulholland , John B Carlin , Trevor Duke , Martin Weber (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Asthma 2014: from monoclonals to the microbiome
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Peter G Gibson , Paul S Foster (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Remarkable progress toward new treatments for cystic fibrosis
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Laurie C Eldredge , Bonnie W Ramsey (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Obstructive sleep apnoea: does one treatment not fit all?
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Keith K H Wong , Brendon J Yee , Ronald R Grunstein (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

ARDS: promising insights for a challenging syndrome
Publication date: Available online 19 November 2014 Source:The Lancet Respiratory Medicine Author(s): Gordon D Rubenfeld (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - November 20, 2014 Category: Respiratory Medicine Source Type: research

Spatial prevalence and associations among respiratory diseases in Maine
Publication date: October 2014 Source:Spatial and Spatio-temporal Epidemiology, Volume 11 Author(s): Christopher Farah , H. Dean Hosgood III , Janet M. Hock Chronic respiratory diseases rank among the leading global disease burdens. Maine’s respiratory disease prevalence exceeds the US average, despite limited urbanization/industrialization. To provide insight into potential etiologic factors among this unique, rural population, we analyzed the spatial distributions of, and potential associations among asthma, COPD, pneumonia, and URI adult outpatient data (n =47,099) from all outpatient transactions (n =5,052,900) in ...
Source: Spatial and Spatio-temporal Epidemiology - November 20, 2014 Category: Epidemiology Source Type: research

A spatio-temporal model for estimating the long-term effects of air pollution on respiratory hospital admissions in Greater London
We present a new model for estimating the effects of air pollution on human health, which allows for residual spatio-temporal autocorrelation, and a study into the long-term effects of air pollution on human health in Greater London, England. The individual and joint effects of different pollutants are explored, via the use of single pollutant models and multiple pollutant indices. (Source: Spatial and Spatio-temporal Epidemiology)
Source: Spatial and Spatio-temporal Epidemiology - November 20, 2014 Category: Epidemiology Source Type: research

Spatiotemporal patterns of infant bronchiolitis in a Tennessee Medicaid population
Publication date: September 2013 Source:Spatial and Spatio-temporal Epidemiology, Volume 6 Author(s): Chantel D. Sloan , Tebeb Gebretsadik , Pingsheng Wu , Kecia N. Carroll , Edward F. Mitchel , Tina V. Hartert Respiratory syncytial virus (RSV) is a major cause of worldwide morbidity and mortality in infants, primarily through the induction of bronchiolitis. RSV epidemics are highly seasonal, occurring in the winter months in the northern hemisphere. Within the United States, RSV epidemic dynamics vary both spatially and temporally. This analysis employs a retrospective space–time scan statistic to locate spatiotempora...
Source: Spatial and Spatio-temporal Epidemiology - November 20, 2014 Category: Epidemiology Source Type: research

Channel catfish (Ictalurus punctatus) leukocytes express estrogen receptor isoforms ERα and ERβ2 and are functionally modulated by estrogens
Publication date: September 2014 Source:Fish & Shellfish Immunology, Volume 40, Issue 1 Author(s): Luke R. Iwanowicz , James L. Stafford , Reynaldo Patiño , Eva Bengten , Norman W. Miller , Vicki S. Blazer Estrogens are recognized as modulators of immune responses in mammals and teleosts. While it is known that the effects of estrogens are mediated via leukocyte-specific estrogen receptors (ERs) in humans and mice, leucocyte-specific estrogen receptor expression and the effects of estrogens on this cell population is less explored and poorly understood in teleosts. Here in, we verify that channel catfish (Ictalu...
Source: Fish and Shellfish Immunology - November 20, 2014 Category: Biology Source Type: research

Retrospective Study of the Epidemiology and Clinical Manifestations of Cryptococcus gattii Infections in Colombia from 1997–2011
Conclusions/Significance The results of this passive surveillance study demonstrate that cryptococcosis caused by C. gattii has a low prevalence in Colombia, with the exception of Norte de Santander. The predominance of molecular type VGII is of concern considering its association with high virulence and the potential to evolve into outbreaks. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 20, 2014 Category: Tropical Medicine Authors: Jairo Lizarazo et al. Source Type: research

Serological Evidence of Henipavirus Exposure in Cattle, Goats and Pigs in Bangladesh
Conclusions This difference in test results may be due to the exposure of animals to one or more novel viruses with antigenic similarity to NiV. Further research may identify a novel organism of public health importance. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - November 20, 2014 Category: Tropical Medicine Authors: Sukanta Chowdhury et al. Source Type: research

Malibatol A protects against brain injury through reversing mitochondrial dysfunction in experimental stroke
Publication date: Available online 20 November 2014 Source:Neurochemistry International Author(s): Wenjie Yang , Xiang Chen , Jie Pan , Hui-ming Ge , Kailin Yin , Zhengzheng Wu , Xiaoxi Li , Dujuan Sha , Yun Xu Ischemic stroke is particularly susceptible to free radicals mediated secondary neuronal damage, especially mitochondrial dysfunction. Malibatol A (MA), a novel resveratrol oligomer, has shown potential antioxidant property in vitro. But little is known about its effect on central nervous system (CNS) in vivo. In the present study, the effect of MA was evaluated in focal cerebral ischemia induced by right middle c...
Source: Neurochemistry International - November 20, 2014 Category: Neuroscience Source Type: research

Effect of protons on the mechanical response of rat muscle nociceptive fibers and neurons in vitro
We examined effects of protons on mechanical sensitivity of muscle nociceptors by single-fiber recording from rat muscle-nerve preparations in vitro and by whole cell patch-clamp recording of mechanically activated (MA) currents from cultured rat dorsal root ganglion neurons. We recorded thirty-eight Aδ- and C-fibers. Their response magnitude was increased by both pH 6.2 and pH 6.8, in addition the mechanical threshold was lowered by pH 6.2. Decrease in the threshold by pH6.2 was also observed in MA currents. Presently observed sensitization by protons could be involved in several types of ischemic muscle pain, and may al...
Source: Neuroscience Research - November 20, 2014 Category: Neuroscience Source Type: research

A Comprehensive examination of delayed emotional recovery in borderline personality Disorder
Conclusions Findings indicate that individuals with BPD generally do not exhibit delayed emotional recovery, but may show decreases in parasympathetic activity during the recovery period after experiencing anger. However, this pattern may not be specific to this disorder. (Source: Journal of Behavior Therapy and Experimental Psychiatry)
Source: Journal of Behavior Therapy and Experimental Psychiatry - November 20, 2014 Category: Psychiatry Source Type: research

Pilot study evaluating the use of Emblica officinalis standardized fruit extract in cardio-respiratory improvement and antioxidant status of volunteers with smoking history
Publication date: Available online 28 October 2014 Source:Journal of Herbal Medicine Author(s): Tuhin Kanti Biswas , Shrabana Chakrabarti , Srikanta Pandit , Utpalendu Jana , Subrata Kumar Dey Emblica officinalis (Indian Goosebery, Phyllanthus emblica), was evaluated for cardiorespiratory and anti-oxidant status in human volunteers with a long smoking history, using a randomized, double-blind, placebo controlled pilot study. Emblica officinalis fruit extract (EOE) standardized to contain not less than 60% w/w of low molecular weight hydrolyzable Tannoids (Emlicanin-A, Emblicanin-B, Pedunculagin, Punigluconin) was used in...
Source: Journal of Herbal Medicine - November 20, 2014 Category: Complementary Medicine Source Type: research

Cellular and molecular mechanisms of mitochondrial function
Publication date: December 2012 Source:Best Practice & Research Clinical Endocrinology & Metabolism, Volume 26, Issue 6 Author(s): Laura D. Osellame , Thomas S. Blacker , Michael R. Duchen Mitochondria are membrane bound organelles present in almost all eukaryotic cells. Responsible for orchestrating cellular energy production, they are central to the maintenance of life and the gatekeepers of cell death. Thought to have originated from symbiotic ancestors, they carry a residual genome as mtDNA encoding 13 proteins essential for respiratory chain function. Mitochondria comprise an inner and outer membrane...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - November 20, 2014 Category: Endocrinology Source Type: research

Aortic Arch Vessel Geometries and Deformations in Patients with Thoracic Aortic Aneurysms and Dissections
Conclusions In patients with thoracic aortic aneurysms or dissections, the thoracic aortic arch translated significantly secondary to inspiration and expiration and to a lesser extent secondary to cardiac pulsation. Insignificant branching angle changes suggest that the aortic arch and its branch origins move predominantly in unison. (Source: Journal of Vascular and Interventional Radiology)
Source: Journal of Vascular and Interventional Radiology - November 20, 2014 Category: Radiology Source Type: research

knock-out in leads to shorter antibiotic treatment and lower relapse rate in a mouse model – A potential novel therapeutic target
Effective global tuberculosis control is hindered by the need for prolonged chemotherapy which leads to poor patient compliance. Therefore novel drug targets that shorten the duration of chemotherapy and reduce disease relapse rates are highly desirable. We have previously shown that HspX, an alpha-crystallin-like protein, is associated with growth suppression of Mycobacterium tuberculosis in mouse models. We determined to evaluate hspX as a novel target for controlling M. tuberculosis growth in combination with traditional antibiotic therapy in the Cornell mouse model. (Source: Tuberculosis)
Source: Tuberculosis - November 20, 2014 Category: Respiratory Medicine Authors: Yanmin Hu, Alexander Liu, Maria C. Menendez, Maria J. Garcia, Katarina Oravcova, Stephen H. Gillespie, Gerry R. Davies, Denis A. Mitchison, Anthony R.M. Coates Source Type: research

Disseminated tuberculosis In a non Immun Compromised patient with a Complicated diagnosis
Publication date: Available online 20 November 2014 Source:Respiratory Medicine Case Reports Author(s): Hatice Sahin , Hatice Isık , Sevil Uygun Ilıkhan , Hakan Tanrıverdi , Muammer Bilici Tuberculosis (TB) has become a global emergency worldwide. The long time period between the exposure to TB bacillus and the onset of symptoms cause a delay in diagnosis. Herein, we report a case of 64-year-old female patient suffering from dyspepsia, anorexia, weight loss and abdominal pain for the last 8 months. Physical examination, ascites fluid evaluation, chest radiography, ultrasonographic and tomographic scans, histopathologi...
Source: Respiratory Medicine Case Reports - November 20, 2014 Category: Respiratory Medicine Source Type: research

A rare benign intrathoracic mass in a patient with history of rocket explosion
Publication date: Available online 20 November 2014 Source:Respiratory Medicine Case Reports Author(s): Jagpal Singh Klair , Chitharanjan Duvoor , Nikhil Meena Thoracic splenosis is rare benign condition that follows trauma leading to diaphragmatic injury. Most of the patients including ours present with a clear traumatic event leading to autotransplantation of spleen in thoracic cavity. Mostly diagnosed incidently and we need to avoid unnecessary workup including radiological and invasive. It is a very important case which signifies importance of good history taking and initial imaging for making diagnosis and making ou...
Source: Respiratory Medicine Case Reports - November 20, 2014 Category: Respiratory Medicine Source Type: research

Oxaloacetate activates brain mitochondrial biogenesis, enhances the insulin pathway, reduces inflammation and stimulates neurogenesis
Brain bioenergetic function declines in some neurodegenerative diseases, this may influence other pathologies and administering bioenergetic intermediates could have therapeutic value. To test how one intermediate, oxaloacetate (OAA) affects brain bioenergetics, insulin signaling, inflammation and neurogenesis, we administered intraperitoneal OAA, 1–2 g/kg once per day for 1–2 weeks, to C57Bl/6 mice. OAA altered levels, distributions or post-translational modifications of mRNA and proteins (proliferator-activated receptor-gamma coactivator 1α, PGC1 related co-activator, nuclear respiratory factor 1, trans...
Source: Human Molecular Genetics - November 20, 2014 Category: Genetics & Stem Cells Authors: Wilkins, H. M., Harris, J. L., Carl, S. M., E, L., Lu, J., Eva Selfridge, J., Roy, N., Hutfles, L., Koppel, S., Morris, J., Burns, J. M., Michaelis, M. L., Michaelis, E. K., Brooks, W. M., Swerdlow, R. H. Tags: ARTICLES Source Type: research

Successful recovery from respiratory failure by external distraction sternoplasty in a patient with Jeune syndrome
(Source: The Journal of Thoracic and Cardiovascular Surgery)
Source: The Journal of Thoracic and Cardiovascular Surgery - November 20, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Samina Park, Chang Hyun Kang, In Kyu Park, Young Tae Kim Source Type: research