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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

Epidemiological Survey of Japanese Patients with Idiopathic Pulmonary Fibrosis and Investigation of Ethnic Differences.
Conclusions: The status of IPF in the Japanese population was clarified for the first time through our study. Our results showed that in men, the incidence of death due to acute exacerbation was higher and that due to cardiovascular disease was lower in Japan than in Western countries. These results may suggest ethnic differences in IPF. PMID: 25162152 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 27, 2014 Category: Respiratory Medicine Authors: Natsuizaka M, Chiba H, Kuronuma K, Otsuka M, Kudo K, Mori M, Bando M, Sugiyama Y, Takahashi H Tags: Am J Respir Crit Care Med Source Type: research

A clinical in-hospital prognostic score for acute exacerbations of COPD.
ConclusionsA score using simple clinical variables has robust properties for predicting the risk of in-hospital death in patients hospitalized for AECOPD. Adding cardiac comorbidities to the original score increased its sensitivity. PMID: 25158759 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 27, 2014 Category: Respiratory Medicine Authors: Roche N, Chavaillon JM, Maurer C, Zureik M, Piquet J Tags: Respir Res Source Type: research

Physiological responses of a rodent to helox reveal constancy of evaporative water loss under perturbing environmental conditions.
We present here evidence, based on the first measurements of evaporative water loss for a small mammal in helox, that mammals may have a previously unappreciated ability to maintain acute constancy of total evaporative water loss under perturbing environmental conditions. Thermoregulatory responses of ash-grey mice (Pseudomys albocinereus) to helox were as expected, with changes in metabolic rate, conductance and respiratory ventilation consistent with maintaining constancy of body temperature under conditions of enhanced heat loss. However, evaporative water loss did not increase in helox. This is despite our confirmation...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 27, 2014 Category: Physiology Authors: Cooper CE, Withers PC Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Dietary milk fat globule membrane improves endurance capacity in mice.
Abstract Milk fat globule membrane (MFGM) comprises carbohydrates, membrane-specific proteins, glycoproteins, phospholipids, and sphingolipids. We evaluated the effects of MFGM consumption over a 12-week period on endurance capacity and energy metabolism in BALB/c mice. Long-term MFGM intake combined with regular exercise improved endurance capacity, as evidenced by swimming time until fatigue, in a dose-dependent manner. The effect of dietary MFGM plus exercise was accompanied by higher oxygen consumption and lower respiratory quotient, as determined by indirect calorimetry. MFGM intake combined with exercise incr...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - August 27, 2014 Category: Physiology Authors: Haramizu S, Ota N, Otsuka A, Hashizume K, Sugita S, Hase T, Murase T, Shimotoyodome A Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Stenotrophomonas maltophilia in Mexico: antimicrobial resistance, biofilm formation, and clonal diversity.
Abstract Stenotrophomonas maltophilia is an important multidrug-resistant nosocomial pathogen associated with high mortality. Our aim is to examine antimicrobial susceptibility, biofilm production, and clonal relatedness of clinical isolates of S. maltophilia. S. maltophilia isolates were collected between 2006 and 2013 from two tertiary-care hospitals in Mexico. Antimicrobial susceptibility was evaluated by the broth microdilution method. PCR was used to determine the presence of β-lactamase genes L1 and L2. Biofilm formation was assessed with crystal violet staining. Clonal relatedness was determined by pulsed-f...
Source: Journal of Medical Microbiology - August 27, 2014 Category: Microbiology Authors: Flores-Treviño S, Gutiérrez-Ferman JL, Morfín-Otero R, Rodríguez-Noriega E, Estrada-Rivadeneyra D, Rivas-Morales C, Llaca-Díaz JM, Camacho-Ortíz A, Mendoza-Olazarán S, Garza-González E Tags: J Med Microbiol Source Type: research

Nocturnal dry cough in the first 7 years of life is associated with asthma at school age
ConclusionNocturnal dry cough and wheeze in early childhood are both independently associated with asthma at school age. The presence of both nocturnal dry cough and wheeze at age 1 almost doubles the risk of asthma at age 8 compared to wheeze alone. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 26, 2014 Category: Respiratory Medicine Authors: Ilse M. Boudewijn, Olga E.M. Savenije, Gerard H. Koppelman, Alet H. Wijga, Henriëtte A. Smit, Johan C. de Jongste, Ulrike Gehring, Dirkje S. Postma, Marjan Kerkhof Tags: Original Article: Asthma Source Type: research

Pulmonary Management of the Acute Cervical Spinal Cord Injured Patients
A traumatic spinal cord injury is a catastrophic event associated with physiologic disruptions to the motor, sensory, cardiovascular, and respiratory systems. Respiratory complications are a common cause of morbidity and mortality in patients with acute cervical spinal cord injury and treatments must be initiated immediately. The longer it takes for a patient to receive pulmonary treatments and mobility activities, the higher the morbidity and mortality and the longer the length of stay. Disrupted pulmonary mechanics and respiratory complications are frequent and are influenced by the level of injury. (Source: Nursing Clin...
Source: Nursing Clinics of North America - August 26, 2014 Category: Nursing Authors: Katherine G. Johnson, Leilani Jean B. Hill Source Type: research

Medicinal plants in the cultural landscape of a Mapuche-Tehuelche community in arid Argentine Patagonia: an eco-sensorial approach
Conclusions: Hebal landscape perceived by the community exhibits notable eco sensorial and spatial heterogeneity. Local inhabitants' sensorial interpretations play a role as heuristic tools in the recreation and redefinition of old and new available resources. (Source: Journal of Ethnobiology and Ethnomedicine)
Source: Journal of Ethnobiology and Ethnomedicine - August 26, 2014 Category: Complementary Medicine Authors: Soledad MolaresAna Ladio Source Type: research

Xerostomia relates to the degree of asthma control
Few studies have assessed the relationships between xerostomia and the use of inhaled corticosteroids (ICS). The main objective of this study was to investigate the prevalence of xerostomia in a respiratory outpatient clinic and its relationship with bronchial asthma and ICS use. A cross‐sectional observational study of patients recruited in an outpatient setting divided them according to previous diagnoses of bronchial asthma. Data about pulmonary function, concomitant medication, medical comorbidities, Xerostomia Inventory test (XI test), and the degree of asthma control by ACT (asthma control test) were collected for ...
Source: Journal of Oral Pathology and Medicine - August 26, 2014 Category: Pathology Authors: Bernardino Alcázar Navarrete, Gerardo Gómez‐Moreno, Antonio Aguilar‐Salvatierra, Javier Guardia, Pedro José Romero Palacios Tags: Original Article Source Type: research

Increased T cell activation in BALF from children with Mycoplasma pneumoniae pneumonia
ConclusionsIncreased activation of T cell in BALF may play an important role in the inflammatory response of acute and severe MPP. IL‐6 may predict the severity and prognosis and provide a better assessment for patient care. However, the underlying mechanism awaits further detailed investigations. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 26, 2014 Category: Respiratory Medicine Authors: Li Guo, Fang Liu, Mei‐Ping Lu, Qi Zheng, Zhi‐Min Chen Tags: Original Article: Respiratory Infections Source Type: research

MERS and related coronaviruses [Microbiology]
Middle East respiratory syndrome coronavirus (MERS-CoV) currently spreads in humans and causes ∼36% fatality in infected patients. Believed to have originated from bats, MERS-CoV is genetically related to bat coronaviruses HKU4 and HKU5. To understand how bat coronaviruses transmit to humans, we investigated the receptor usage and cell entry activity... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 26, 2014 Category: Science Authors: Yang, Y., Du, L., Liu, C., Wang, L., Ma, C., Tang, J., Baric, R. S., Jiang, S., Li, F. Tags: Biological Sciences Source Type: research

Aldehyde dehydrogenase 2 activation in heart failure restores mitochondrial function and improves ventricular function and remodelling
Conclusions Selective activation of mitochondrial ALDH2 is sufficient to improve the HF outcome by reducing the toxic effects of aldehydic overload on mitochondrial bioenergetics and reactive oxygen species generation, suggesting that ALDH2 activators, such as Alda-1, have a potential therapeutic value for treating HF patients. (Source: Cardiovascular Research)
Source: Cardiovascular Research - August 26, 2014 Category: Cardiology Authors: Gomes, K. M. S., Campos, J. C., Bechara, L. R. G., Queliconi, B., Lima, V. M., Disatnik, M.-H., Magno, P., Chen, C.-H., Brum, P. C., Kowaltowski, A. J., Mochly-Rosen, D., Ferreira, J. C. B. Tags: Cardiac biology and remodelling Source Type: research

Compartment differences of inflammatory activity in chronic obstructive pulmonary disease
Conclusion: Saliva which is convenient to collect and analyse, may be suitable for biomarker assessment of disease activity in COPD. An attenuated TNF-? expression was demonstrated by both protein and mRNA analyses in different compartments suggesting that TNF-? response is altered in moderate and severe COPD. Shedding of TNFR1 or TNFR2 is similarly regulated irrespective of airflow limitation. (Source: Respiratory Research)
Source: Respiratory Research - August 26, 2014 Category: Respiratory Medicine Authors: Jie JiIda von SchéeleJan BergströmBo BillingBarbro DahlénAnn-Sofie LantzKjell LarssonLena Palmberg Source Type: research

Prostaglandin E2 receptors in asthma and in chronic rhinosinusitis/nasal polyps with and without aspirin hypersensitivity
Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma frequently coexist and are always present in patients with aspirin exacerbated respiratory disease (AERD). Although the pathogenic mechanisms of this condition are still unknown, AERD may be due, at least in part, to an imbalance in eicosanoid metabolism (increased production of cysteinyl leukotrienes (CysLTs) and reduced biosynthesis of prostaglandin (PG) E2), possibly increasing and perpetuating the process of inflammation. PGE2 results from the metabolism of arachidonic acid (AA) by cyclooxygenase (COX) enzymes, and seems to play a central role in homeostasis ...
Source: Respiratory Research - August 26, 2014 Category: Respiratory Medicine Authors: Liliana Machado-CarvalhoJordi Roca-FerrerCésar Picado Source Type: research

Primary ciliary dyskinesia
(PCD) is an autosomal recessive disorder of cilia structure and function, leading to chronic infections of the respiratory tract, fertility problems and disorders of organ laterality. Making a definitive diagnosis is challenging, utilizing characteristic phenotypes, ciliary functional and ultra-structural defects in addition to newer screening tools such as nasal nitric oxide and genetic testing. There are 21 known PCD causing genes and in the future, comprehensive genetic testing may help diagnosis young infants prior to developing symptoms thus improving survival. Therapy includes surveillance of pulmonary function and ...
Source: QJM - August 26, 2014 Category: Internal Medicine Authors: Lobo, L. J., Zariwala, M. A., Noone, P. G. Tags: Review Source Type: research

Magnetic Resonance Imaging Predictors for Respiratory Failure after Cervical Spinal Cord Injury
Acute spinal cord injury is one of the causes of morbidity and mortality in teenagers and adults, and approximately one-third of these patients have cervical spinal cord injury (CSCI) [1]. Pulmonary dysfunction accounts for the largest proportion of complications after a spinal insult and includes ventilation failure, atelectasis, pneumonia, and pleural effusion [2–4]. The respiratory sequelae result from a variety of mechanisms, consisting of expiratory muscle weakness, retained secretions, bronchial mucus hypersecretion, ileus with embarrassment of diaphragmatic excursion, an increased risk of aspiration of gastric con...
Source: Clinical Neurology and Neurosurgery - August 26, 2014 Category: Neurosurgery Authors: Yu-Hua Huang, Chien-Yu Ou Source Type: research

Chronic Ethanol Exposure Selectively Inhibits the Influenza-Specific CD8 T Cell Response During Influenza A Virus Infection.
CONCLUSIONS: These findings highlight the previously unrecognized depth of the lesion in the IAV-specific CD8 T cell response during chronic EtOH consumption. Given the important role CD8 T cell immunity plays in control of IAV, these findings may aid in the development of vaccination and/or therapeutic strategies to reverse these defects in the CD8 T cell response and reduce serious disease outcomes associated with IAV infections in alcoholics. PMID: 25160044 [PubMed - as supplied by publisher] (Source: Alcoholism, Clinical and Experimental Research)
Source: Alcoholism, Clinical and Experimental Research - August 26, 2014 Category: Addiction Authors: Hemann EA, McGill JL, Legge KL Tags: Alcohol Clin Exp Res Source Type: research

The Roles of Phosphodiesterase 2 in the Central Nervous and Peripheral Systems.
Abstract Phosphodiesterase 2 (PDE2) is a ubiquitous enzyme whose major role is to hydrolyze the important second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). In the central nervous system, pharmacological inhibition of PDE2 results in boosted cAMP and/or cGMP signaling, which is responsible for series of changes in protein expression relevant to psychiatric and learning and memory disorders, such as depression, anxiety, and cognition deficits in Alzheimer's disease. In the periphery, inhibition of PDE2 exhibits beneficial effects in the diseased cardiovascular system, ...
Source: Current Pharmaceutical Design - August 26, 2014 Category: Drugs & Pharmacology Authors: Zhang C, Yu Y, Ruan L, Wang C, Pan J, Klabnik J, Lueptow L, Zhang HT, O'Donnell JM, Xu Y Tags: Curr Pharm Des Source Type: research

Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE): Protocol and preliminary data.
Abstract Chronic obstructive pulmonary disease (COPD) is a multisystem disease. Established comorbidities include cardiovascular disease, osteoporosis, loss of muscle mass and function, depression, and impaired quality of life. The natural history is not well understood. The Assessment of Risk in Chronic Airways Disease Evaluation (ARCADE) is a longitudinal study of comorbidities in COPD. The primary aims are to delineate the progression and interrelationships of cardiovascular disease and associated comorbidities. Each year ARCADE aims to recruit 250 patients diagnosed with COPD and 50 comparators (free from respi...
Source: Chronic Respiratory Disease - August 26, 2014 Category: Respiratory Medicine Authors: Gale NS, Albarrati AM, Munnery MM, Munnery IC, Irfan M, Bolton CE, Rambaran CN, Singer RM, Cockcroft JR, Shale DJ Tags: Chron Respir Dis Source Type: research

Physiologic comparison of neurally adjusted ventilator assist, proportional assist and pressure support ventilation in critically ill patients.
Conclusion: Compared to PSV, proportional modes favored tidal volume variability. The weak ∫EAdi-PTPdi linear relationship during NAVA and poor triggering function during PAV+ may limit the effectiveness of these modes to proportionally assist the inspiratory effort. PMID: 25169117 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Akoumianaki E, Prinianakis G, Kondili E, Malliotakis P, Georgopoulos D Tags: Respir Physiol Neurobiol Source Type: research

Gabapentin as a Potential Treatment for Cough Syncope.
PMID: 25161306 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Wu CH, Gunasekara K, Hull JH, Bikov A, Morris AJ, Usmani OS Tags: Respir Care Source Type: research

The Necessity of Histology.
PMID: 25161305 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Nataraj RT, Fladeland DA, Cockcroft DW Tags: Respir Care Source Type: research

An Innovative Childhood Asthma Score Predicts the Need for Bronchodilator Nebulization in Children With Acute Asthma Independent of Auscultative Findings.
CONCLUSIONS: Using a cutoff value of 4, the newly developed CAS accurately predicts the requirement for bronchodilator nebulization in children with acute asthma without use of auscultative findings. PMID: 25161304 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Kamps AW, Veeger NJ, Heijsman SM Tags: Respir Care Source Type: research

Association of Influenza-Like Illness and Climatic Parameters With Hemoptysis.
CONCLUSIONS: There is a strong long running relationship between severe hemoptysis and low monthly mean temperature. A weaker association of hemoptysis with influenza activity was also found. PMID: 25161303 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Garcia-Olivé I, Fiz JA, Sanz-Santos J, Martínez-Rivera C, Prats M, Ruiz-Manzano J Tags: Respir Care Source Type: research

Effect of Drug Targeting Nebulization on Lung Deposition: A Randomized Crossover Scintigraphic Comparison Between Central and Peripheral Delivery.
CONCLUSIONS: This study shows for the first time that choosing 2 different specific drug targeting nebulization modes does not influence the amount of drug delivered into the lung in healthy male subjects. Moreover, the modes do not modify the site of deposition under the conditions of our study. PMID: 25161302 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Reychler G, Aubriot AS, Depoortere V, Jamar F, Liistro G Tags: Respir Care Source Type: research

Double Lumen Endotracheal Tube for Percutaneous Tracheostomy.
CONCLUSIONS: Use of the DLET during percutaneous dilational tracheostomy allows fiberoptic bronchoscopy without imposing excessive airway resistance. Reduced tube resistance during this procedure may confer additional safety in what is well known to be a hazardous procedure. PMID: 25161301 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Vargas M, Servillo G, Tessitore G, Aloj F, Brunetti I, Arditi E, Salami D, Kacmarek RM, Pelosi P Tags: Respir Care Source Type: research

Endobronchial Argon Plasma Coagulation for Treatment of Dieulafoy Disease.
Abstract Dieulafoy disease of the bronchus is a rare condition. A 28-y-old male patient with recurrent exacerbations of hemoptysis (producing up to 300 mL) over the previous 4 y was admitted to our hospital following an acute episode. A 3-mm sessile lesion covered with somewhat ulcerated smooth mucosa was detected at the distal end of the left main bronchus, at the entrance to the upper lobe bronchus. Bleeding was controlled by argon plasma coagulation, and total coagulation of the lesion was also therapeutic. The patient has been followed for 2 y with no further bleeding. In the very few reported cases of Dieulafo...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Dalar L, Sökücü SN, Ozdemir C, Büyükkale S, Altın S Tags: Respir Care Source Type: research

Ventilation Efficacy of Video-Laryngoscope Equipped With a Ventilation Feature.
CONCLUSIONS: Video-laryngoscopes equipped with a ventilation feature provided effective VT in simulated clinical scenarios. Further clinical study is required to validate these findings. PMID: 25161299 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Oto J, Chenelle CT, Su Z, Sun MQ, Jiang Y, Kacmarek RM Tags: Respir Care Source Type: research

Complications With Utilization of Positive-Pressure Devices in a Young Man With Duchenne Muscular Dystrophy.
Abstract Because of the progressive muscle weakness they experience, patients with Duchenne muscular dystrophy frequently utilize positive-pressure devices to maintain adequate bronchial hygiene and ventilation. This case illustrates the course of a 19-y-old male who presented with a perforated right tympanic membrane (TM) following the use of these devices. Perforation of the TM while utilizing positive-pressure devices is a rarely reported event. A challenging aspect in this case was balancing the reduction of pressures and maintaining adequate ventilation while at the same time allowing the TM to heal. PMID:...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Gee SL, Lowe GR, Warren RH Tags: Respir Care Source Type: research

Exogenous Lipoid Pneumonia Successfully Treated With Bronchoscopic Segmental Lavage Therapy.
In conclusion, a case of exogenous lipoid pneumonia was successfully treated with bronchoscopic segmental lavage therapy. PMID: 25161297 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: Nakashima S, Ishimatsu Y, Hara S, Kitaichi M, Kohno S Tags: Respir Care Source Type: research

Tissue Hypoxia: Implications for the Respiratory Clinician.
Abstract Oxygen is essential for normal aerobic metabolism in mammals. Hypoxia is the presence of lower than normal oxygen content and pressure in the cell. Causes of hypoxia include hypoxemia (low blood oxygen content and pressure), impaired oxygen delivery, and impaired cellular oxygen uptake/ utilization. Many compensatory mechanisms exist at the global, regional, and cellular levels to allow cells to function in a hypoxic environment. Clinical management of tissue hypoxia usually focuses on global hypoxemia and oxygen delivery. As we move into the future, the clinical focus needs to change to assessing and mana...
Source: Respiratory Care - August 26, 2014 Category: Respiratory Medicine Authors: MacIntyre NR Tags: Respir Care Source Type: research