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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature
ConclusionsIT morphine and IT ziconotide are approved by the US Food and Drug Administration for patients who do not respond to less invasive treatments, but the safety profiles of each may make them more or less appropriate for certain patient populations. (Source: Pain Medicine)
Source: Pain Medicine - January 22, 2015 Category: Anesthesiology Authors: Lynn R. Webster Tags: Review Source Type: research

Palatal surface and volume in mouth-breathing subjects evaluated with three-dimensional analysis of digital dental casts--a controlled study
Conclusions: Subjects with prolonged mouth breathing showed a significant reduction of the palatal surface area and volume leading to a different development of the palatal morphology when compared with subjects with normal breathing pattern. (Source: The European Journal of Orthodontics)
Source: The European Journal of Orthodontics - January 22, 2015 Category: Dentistry Authors: Lione, R., Franchi, L., Huanca Ghislanzoni, L. T., Primozic, J., Buongiorno, M., Cozza, P. Tags: Original Article Source Type: research

The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma
To examine the effect of the quadrivalent human papillomavirus vaccine, Gardasil, on the disease course of patients with recurrent respiratory papillomatosis (RRP). (Source: Journal of Voice)
Source: Journal of Voice - January 22, 2015 Category: ENT & OMF Authors: David L. Young, Michael W. Moore, Lucinda Ann Halstead Source Type: research

Aerodynamic Measures and Biofeedback as Management in Persistent Paradoxical Vocal Fold Motion and Reverse Phonation
We present an unusual case of persistent reverse phonation secondary to respiratory distress associated with PVFM. (Source: Journal of Voice)
Source: Journal of Voice - January 22, 2015 Category: ENT & OMF Authors: Linda M. Carroll, Melin Tan Source Type: research

Asthma-COPD Overlap: Clinical Relevance of Genomic Signatures of Type 2 Inflammation in COPD.
Conclusion: These data identify airway gene expression alterations that can co-occur in asthma and COPD. The association of the Th2 signature with increased severity and "asthma-like" features (including a favorable corticosteroid response) in COPD suggests Th2 inflammation is important in a COPD subset that cannot be identified by clinical history of asthma. PMID: 25611785 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 22, 2015 Category: Respiratory Medicine Authors: Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenberg ME, Spira A, Woodruff PG Tags: Am J Respir Crit Care Med Source Type: research

Pathologic Regulation of Collagen I by an Aberrant PP2A/HDAC4/miR-29 Signal Axis in IPF Fibroblasts.
Abstract Idiopathic Pulmonary Fibrosis is characterized by the relentless expansion of fibroblasts depositing type I collagen within the alveolar wall and obliterating the alveolar airspace. miR-29 is a potent regulator of collagen expression. In IPF miR-29 levels are low while type I collagen expression is high. However the mechanism for suppression of miR-29 and increased type I collagen expression in IPF remains unclear. Here we show that when IPF fibroblasts are seeded on polymerized type I collagen, miR-29c levels are suppressed and type I collagen expression is high. In contrast, miR-29c is high and type I co...
Source: Am J Respir Cell Mol... - January 22, 2015 Category: Respiratory Medicine Authors: Khalil W, Xia H, Bodempudi V, Kahm J, Hergert P, Smith K, Peterson M, Parker M, Herrera J, Bitterman PB, Henke CA Tags: Am J Respir Cell Mol Biol Source Type: research

Treatment-related Biomarkers in Pulmonary Hypertension.
Abstract Significant advances in the treatment of pulmonary arterial hypertension (PAH) over the last two decades have led to the introduction of multiple classes of oral therapy, but the disease remains devastating for many patients. Disease progression in spite of oral monotherapy is a major problem and alternative therapy, such as infusion of prostacyclins, is cumbersome and carries considerable potential morbidity. There is some evidence to support, and increasing use of, combination oral therapy including drugs from the endothelin receptor antagonist (ERA) and type-5 phosphodiesterase inhibitor (PDE5i) classes...
Source: Am J Respir Cell Mol... - January 22, 2015 Category: Respiratory Medicine Authors: Swaminathan AC, Dusek AC, McMahon TJ Tags: Am J Respir Cell Mol Biol Source Type: research

Differential effect of mMRC dyspnea, CAT and CCQ for symptom evaluation within the new GOLD staging and mortality in COPD.
Conclusions: The CAT and the CCQ have similar ability for predicting all-cause mortality in patients with chronic obstructive pulmonary disease, but were inferior to mMRC dyspnea scores. We suggest new thresholds for CAT and CCQ scores based on mortality risk that could be useful for the new GOLD grading classification. ClinicalTrials.gov Identifier: NCT01122758. PMID: 25612228 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Casanova C, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Solanes-García I, Agüero R, Feu-Collado N, Calle-Rubio M, Alfageme I, de Diego-Damia A, Irigaray R, Marín M, Balcells E, Llunell A, Galdiz JB, Golpe R Tags: Chest Source Type: research

Impact of chronic obstructive pulmonary disease in the outcome of intensive care unit-acquired pneumonia with and without previous intubation.
Conclusion: COPD was independently associated with decreased 90-day survival; in patients with VAP but not in those without previous intubation. PMID: 25612147 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Rinaudo M, Ferrer M, Terraneo S, De Rosa F, Peralta R, Fernández-Barat L, Li Bassi G, Torres A Tags: Chest Source Type: research

Impact of Obstructive Sleep Apnea on Cardiovascular Events after Coronary Artery Bypass Surgery.
Conclusions: OSA is independently associated with a higher rate of long-term cardiovascular events after CABG and may have prognostic and economical significance in CABG surgery. PMID: 25612013 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Uchôa CH, Danzi-Soares NJ, Nunes FS, de Souza AA, Nerbass FB, Pedrosa RP, César LA, Lorenzi-Filho G, Drager LF Tags: Chest Source Type: research

Metabolomic evaluation of neutrophilic airway inflammation in cystic fibrosis.
Conclusions: Mass spectrometric metabolomics identified multiple metabolic pathways associated with neutrophilic airway inflammation. These findings provide insight into disease pathophysiology and can serve as the basis for developing disease biomarkers and therapeutic interventions for airways diseases. PMID: 25611918 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Esther CR, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC Tags: Chest Source Type: research

Acute Effect of an Inhaled Glucocorticosteroid on Albuterol-induced Bronchodilation in Patients with Moderately Severe Asthma.
CONCLUSIONS: This pilot study showed that in adult asthmatics with airflow obstruction, a single standard dose of an ICS can acutely increase the FEV1 response to a standard dose of inhaled albuterol administered simultaneously. The associated potentiation of albuterol-induced vasodilation in the airway was of greater magnitude and retained when the ICS was administered 30 min before albuterol. The clinical significance of this observation will have to be established by a study involving a larger patient cohort. PMID: 25611803 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Mendes ES, Cadet L, Arana J, Wanner A Tags: Chest Source Type: research

The association between hospital readmission and pulmonologist follow-up visits in patients with Chronic Obstructive Pulmonary Disease.
Conclusions: Early follow-up visits with pulmonologists seem to reduce exacerbation related rehospitalization rates of COPD patients. We recommend that patients have early post-discharge follow-up visits with pulmonologists. PMID: 25611698 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Gavish R, Levy A, Dekel OK, Karp E, Maimon N Tags: Chest Source Type: research

The Role for Optical Density in Heparin-Induced Thrombocytopenia: A Cohort Study.
Conclusions: Increasing the OD threshold enhances specificity without noticeably compromising sensitivity. Altering the definition of the HIT ELISA could prevent unnecessary testing and/or treatment with non-heparin based anticoagulants in patients with possible HIT. Clinical Trial Registration: clinicaltrials.gov (NCT 00946400). PMID: 25611568 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Chan CM, Woods CJ, Warkentin TE, Sheppard JA, Shorr AF Tags: Chest Source Type: research

Streptococcus pneumoniae and staphylococcus aureus carriage in healthy school-age children and adolescents.
STREPTOCOCCUS PNEUMONIAE AND STAPHYLOCOCCUS AUREUS CARRIAGE IN HEALTHY SCHOOL-AGE CHILDREN AND ADOLESCENTS. J Med Microbiol. 2015 Jan 22; Authors: Esposito S, Terranova L, Ruggiero L, Ascolese B, Montinaro V, Rios WP, Galeone C, Principi N Abstract Streptococcus pneumoniae and Staphylococcus aureus are common commensals of the upper respiratory tract in children and adolescents. Understanding the relationship between these two pathogens, including their potential for mutual interference, is needed to evaluate their epidemiological status as well as the impact of related preventative measures. We obtain...
Source: Journal of Medical Microbiology - January 22, 2015 Category: Microbiology Authors: Esposito S, Terranova L, Ruggiero L, Ascolese B, Montinaro V, Rios WP, Galeone C, Principi N Tags: J Med Microbiol Source Type: research

Bioavailability of one 5 mg versus five 1 mg everolimus tablets
Thudium K, Gallo J, Bouillaud E, Sachs C, Eddy S, Cheung W (Source: International Journal of COPD)
Source: International Journal of COPD - January 21, 2015 Category: Respiratory Medicine Source Type: research

Seasonal variation of serum KL-6 and SP-D levels in bird-related hypersensitivity pneumonitis.
Authors: Okamoto T, Tsutsui T, Suhara K, Furusawa H, Miyazaki Y, Inase N Abstract N/A. PMID: 25591150 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Proceedings of the 2014 AASOG conference.
Authors: Crouser E, Judson M Abstract Not applicable. PMID: 25591149 [PubMed - as supplied by publisher] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Intravascular large B cell lymphoma presenting in the lung: the diagnostic value of transbronchial cryobiopsy.
CONCLUSIONS: transbronchial cryobiopsy could be used as valid surrogate for surgical lung biopsy in lymphoprolipherative lung disorders (including intravascular lymphomas), as allows larger samples of tissue, greater  diagnostic yield, no crush artifacts and much less complications than surgical biopsy.  PMID: 25591148 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Granulomatous lung disease in a patient with a family history of hematological disorders.
Authors: Overbeek M, Van de Loosdrecht A, Vonk-Noordegraaf A Abstract A 29-year old patient presented with granulomatous lung disease and a family history of myelodysplastic syndrome/acute myeloid leukemia. She appeared to be a carrier of a mutation in the transcription factor GATA2. The case adds to the recent described heterogeneous clinical manifestations and syndromes in which, against a background of hematologic disorders, GATA2 mutations have been demonstrated, such as the Monomac and Emberger syndromes. In patients with a granulomatous disease and a history of (familial) hematologic disorders, the occurence ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

A pilot study: a combined therapy using polymyxin-B hemoperfusion and extracorporeal membrane oxygenation for acute exacerbation of interstitial pneumonia.
CONCLUSION: A combined therapy of PMX-DHP and VV-ECMO might be a therapeutic option for AE of IP. PMID: 25591146 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

In vitro and in vivo study of anti-tuberculosis effect of extracts isolated from Ranunculi Ternati Radix.
CONCLUSIONS: EEPMR possessed better anti-tuberculosis effects than other extracts and Radix Ranunculi Ternati Capsules. This supported the use of macroporous resin to enrich the active part of Ranunculi Ternati Radix to cure mycobacterium tuberculosis infections. PMID: 25591145 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Reconsideration of discrepancies between clinical and histopathological features in acute eosinophilic pneumonia.
Conclusion) Characteristic histopathological findings of AEP consist of alveolar edema with infiltration of eosinophils and lymphocytes and edema of perivascular area and interlobular septa. The alveolar spaces showed fibrinous exudates. There were no hyaline membranes or massive intraluminal fibrosis. These histopathological findings of interstitial edema and fluid exudates are consistent with radiological findings of lung edema and can explain the rapid and complete improvement.Because AEP does not exhibit lung fibrosis histopathologically, it should not to be included in DAD which is associated with lung fibrosis.  ...
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Activated CD8+ T cells and natural killer T cells in bronchoalveolar lavage fluid in hypersensitivity pneumonitis and sarcoidosis.
CONCLUSION: This study suggests a role for the bronchoalveolar lavage fluid lymphocyte subsets HLA-DR+ CD8+ T cells and natural killer T cells in the diagnostic work up of sarcoidosis and hypersensitivity pneumonitis. PMID: 25591143 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Renal Sarcoidosis: epidemiological and follow-up data in a cohort of 27 patients.
CONCLUSIONS: We demonstrated that GIN is more often associated with advanced stages of renal insufficiency than any other histological manifestation of RS. Furthermore, prednisone therapy is effective in improving eGFR and in reducing total urinary protein secretion. We suggest that the key prognostic factor for renal survival in RS is the early response to treatment. PMID: 25591142 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Pulmonary hypertension in idiopathic pulmonary fibrosis does not influence six-minute walk distance: results from a retrospective study.
CONCLUSIONS: Our data suggested that 6MWD does not differ between IPF patients with or without PH. Thus, 6MWD should not be used as a surrogate endpoint in clinical study in patients affected by IPF and PH. PMID: 25591141 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Association between idiopathic pulmonary fibrosis and coronary artery disease: a case-control study and cohort analysis.
CONCLUSIONS: IPF itself was an independent risk factor for CAD after the adjustment of age, hypertension, diabetes, and hypercholesterolemia. PMID: 25591140 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Sarcoidosis, a report from Guilan (an Iranian Northen province) (2001-09).
CONCLUSION: It seems many clinical and radiological aspects of sarcoidosis in our patients are similar to other series. However, presentation with Lofgren's syndrome is a common feature and skin (n=48, 12.3%) and eye (n=19, 4.8%) involvement are less frequent. There is significant difference between west and east of Guilan in relation to referred patients (12.9 % vs 78.5% respectively).Of course this may be due to referral issues of patients and medical teamwork connections  PMID: 25591139 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Features of sarcoidosis associated with chronic disease.
CONCLUSION: In our study, the majority of sarcoidosis patients were receiving systemic therapy five years after initial diagnosis. Patients with reduced lung function, neurologic disease, lupus pernio, and cardiac disease were more likely to require prolonged treatment. PMID: 25591138 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Treatment and outcome of lung cancer in idiopathic interstitial pneumonias.
CONCLUSIONS: LC is a frequent comorbidity in IIP, with a higher incidence and reduced survival in IPF compared to other IIPs. LC treatment is associated with significant toxicity, specifically in IPF. Interdisciplinary evaluation of therapeutic options in IIP patients diagnosed with LC is therefore mandatory. PMID: 25591137 [PubMed - in process] (Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases)
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - January 21, 2015 Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research

Serious and Long-Term Adverse Events Associated with the Therapeutic and Cosmetic Use of Botulinum Toxin
In conclusion, botulinum toxin may cause serious adverse events, which are more common after its therapeutic use, but can also be noticed after its cosmetic use. Thorough knowledge of the anatomy of the treated muscles and of the pharmacology of the drug is imperative to avoid serious adverse events.Pharmacology 2015;95:65-69 (Source: Pharmacology)
Source: Pharmacology - January 21, 2015 Category: Drugs & Pharmacology Source Type: research

Non invasive ventilation in patients with hematologic malignancy: A new prospective.
Authors: Squadrone V, Ferreyra G, Ranieri VM Abstract Immunosuppressed patients are usually considered together without distinction. However, patients with hematologic malignancy should be included in a different subcategory. The outcome of this population has improved over the years. However, mortality rate continues to be high, especially when respiratory complications are present and mechanical ventilation is required. Non-invasive ventilation (NIV) demonstrated its efficacy on the process of respiratory failure improving clinical outcomes in patients of different diagnoses. The recommendations of the guidelines...
Source: Minerva Anestesiologica - January 21, 2015 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Impact of Nurse-Initiated ED Sepsis Protocol on Compliance With Sepsis Bundles, Time to Initial Antibiotic Administration, and In-Hospital Mortality
Discussion Compliance with serum lactate measurement and blood culture collection goals approached 100% in the post-protocol group. However, compliance with medical interventions requiring multiple health care-provider involvement (ie, antibiotic and fluid administration) remained suboptimal. Efforts focused on multidisciplinary bundle elements are necessary to achieve full compliance with SSC targets. (Source: Journal of Emergency Nursing)
Source: Journal of Emergency Nursing - January 21, 2015 Category: Nursing Source Type: research

Diagnosis and treatment of severe hemolytic disease of the fetus and newborn: a ten‐year nationwide retrospective study
ConclusionsAlthough overall survival is comparable with previous studies, our concern is procedure‐related infections and preterm births. Close collaboration between the university hospitals is needed to ensure timely treatment, operator skills and systematic follow‐up of the children.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - January 21, 2015 Category: OBGYN Authors: Susanna Sainio, Irmeli Nupponen, Malla Kuosmanen, Ansa Aitokallio‐Tallberg, Eeva Ekholm, Erja Halmesmäki, Maija‐Riitta Orden, Pertti Palo, Tytti Raudaskoski, Aydin Tekay, Jarno Tuimala, Jukka Uotila, Vedran Stefanovic Tags: Main Research Article Source Type: research

No association between allergy and current 25‐hydroxy vitamin D in serum or vitamin D intake
ConclusionThe findings suggest no association between allergy and 25OHD levels in serum or vitamin D intake in adolescents. Serum 25OHD levels correlated to intake of vitamin D fortified lean milk.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - January 21, 2015 Category: Pediatrics Authors: Malin Barman, Karin Jonsson, Bill Hesselmar, Agnes E. Wold, Ann‐Sofie Sandberg, Anna Sandin Tags: Regular Article Source Type: research

Highlights from this issue
Just over a decade ago Education & Practice was launched as a companion journal to ADC. It started off with around 28 pages per issue, and in some instances the content was sourced from other parts of the BMJ publishing stable. To tie in with the sister ADC journals, that first year was volume 89. Now as we click over into volume 100, issue 1, I hope those of you who are holding a paper copy of E&P will have noticed; we've grown again, this time to 56 pages an issue. The important thing, of course, is to make sure we don't dilute the quality. For me, and for the other editors at E&P, we want you to have article...
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Wacogne, I. Tags: Pneumonia (infectious disease), TB and other respiratory infections, Child and adolescent psychiatry (paedatrics), Autism, Pervasive developmental disorder, Disability, Pneumonia (respiratory medicine), Rheumatology, Ear, nose and throat/otolaryngology, C Source Type: research

A pneumonia that does not improve
A 2-year-old, previously healthy child was admitted for fever, cough and tachypnoea with intercostal and suprasternal retractions. Crackles and diminished breath sounds were noted on the left hemithorax. Peripheral oxygen saturation (SpO2) was 85% while breathing ambient air. Antibiotic therapy and oxygen supplementation were started for presumed bacterial pneumonia. Despite prompt resolution of fever and improvement of general conditions, after 5 days SpO2 remained 90%, rising to 99% with oxygen supplementation. Physical examination demonstrated markedly diminished breath sounds on the left hemithorax. A chest radiog...
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Naviglio, S., Chinello, M., Ventura, A. Tags: Oncology, Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Airway biology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Epilogue Source Type: research

Recurrent acute life-threatening events in a child with achondroplasia
A 2-month-old boy with achondroplasia was brought to the emergency department following an apnoeic episode while in a car seat. He required minimal resuscitation but was noted to have significant hypercarbia on the blood gas. There was no history suggestive of an intercurrent respiratory infection. Systemic examination was normal apart from skeletal features of achondroplasia. While in hospital, he had further brief apnoeic episodes. Polysomnography demonstrated central and obstructive sleep apnoeas (Apnoea Hypopnoea Index (AHI) is used to quantify the number of apnoeas and hypopnoeas scored per hour1 and was found to be s...
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Babiker, M. O. E., Edwards, C., Davies, P., O'Kane, R. Tags: Radiology, Rheumatology, Clinical diagnostic tests, Radiology (diagnostics), Resuscitation Epilogue Source Type: research

Answers to Epilogue questions: A pneumonia that does not improve
Answers From questions on page 18.Children with community-acquired bacterial pneumonia usually improve within 48–72 h from the start of appropriate antibiotic therapy. When improvement is not apparent, several conditions should be considered (box 1). In our patient, respiratory symptoms persisted well beyond the improvement of fever and general conditions, therefore prompting further investigations, the first of which should always be a chest radiography. Chest radiography showed right deviation of the trachea and hyperlucency of the left lung, suggesting the presence of air trapping in the left lung. While the ...
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Naviglio, S., Chinello, M., Ventura, A. Tags: Pancreas and biliary tract, Oncology, Surgery, Journalology, Bronchiolitis, Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Child health, Radiology, Bronchitis, Cystic fibros Source Type: research

Severe Intraventricular Hemorrhage in Extremely Premature Infants: Are high Carbon Dioxide Pressure or Fluctuations the Culprit?
Conclusion Fluctuations in Pco 2 within a short period may be more significantly associated with severe IVH than the mere presence of hypercapnia.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 21, 2015 Category: Perinatology & Neonatology Authors: Altaany, DimaNatarajan, GirijaGupta, DhruvZidan, MarwanChawla, Sanjay Tags: Original Article Source Type: research

Tidal Volume in Infants with Congenital Diaphragmatic Hernia Supported with Conventional Mechanical Ventilation
Conclusions Infants with CDH require similar VT to clear their CO2 production compared with infants of similar size without pulmonary hypoplasia. These are the first reference values to guide selection of VT in infants with CDH.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 21, 2015 Category: Perinatology & Neonatology Authors: Sharma, SaumyaAbubakar, Kabir M.Keszler, Martin Tags: Original Article Source Type: research

Effect of equipment dead space on multiple breath washout measures
ConclusionsEquipment Vd affects LCI measurements especially in young children where Vd is large relative to lung volumes. (Source: Respirology)
Source: Respirology - January 21, 2015 Category: Respiratory Medicine Authors: Anouk Benseler, Sanja Stanojevic, Renee Jensen, Per Gustafsson, Felix Ratjen Tags: Original Article Source Type: research

Differential expression of efflux pump genes of in response to varied subinhibitory concentrations of antituberculosis agents
Several reports have elaborated on the role of efflux pumps in drug resistance in M. tuberculosis by analysing the mRNA expression profiles. However, there is no uniformity in the subinhibitory concentrations of drugs chosen in these studies. Some investigators studied the expression of efflux pumps under a drug concentration of minimum inhibitory concentration (MIC), while others used , or MIC. The present study was planned to understand the effect of different concentrations of antituberculosis drugs on the expression of efflux pump genes. (Source: Tuberculosis)
Source: Tuberculosis - January 21, 2015 Category: Respiratory Medicine Authors: Kushal Garima, Rakesh Pathak, Rashmi Tandon, Nisha Rathor, Rajesh Sinha, Mridula Bose, Mandira Varma-Basil Tags: Drug Discovery and Resistance Source Type: research

The association between asthma and rhinitis is stable over time despite diverging trends in prevalence
Background: Despite the well-known association between asthma and rhinitis, in Swedish adults the prevalence of rhinitis rose from 22% to 31% between 1990 and 2008 while asthma prevalence was unchanged. We tested whether the association of rhinitis with asthma was stable over time using the same population-based databases. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 21, 2015 Category: Respiratory Medicine Authors: Anders Bjerg, Jonas Eriksson, Inga Sif Ólafsdóttir, Roelinde Middelveld, Karl Franklin, Bertil Forsberg, Kjell Larsson, Kjell Torén, Sven-Erik Dahlén, Christer Janson Source Type: research

The IVAIRE project – a randomized controlled study of the impact of ventilation on indoor air quality and the respiratory symptoms of asthmatic children in single family homes
This study indicates that improved ventilation reduces air contaminants and may prevent wheezing. Due to lack of power, a bigger study is needed. (Source: Indoor Air)
Source: Indoor Air - January 21, 2015 Category: Occupational Health Authors: P. Lajoie, D. Aubin, V. Gingras, P. Daigneault, F. Ducharme, D. Gauvin, D. Fugler, J.‐M. Leclerc, D. Won, M. Courteau, S. Gingras, M.‐È. Héroux, W. Yang, H. Schleibinger Tags: Original Article Source Type: research

Zanamivir for influenza in adults and children shows limited benefit for treatment of symptomatic influenza and no effect on relevant complications
Commentary on: Heneghan CJ, Onakpoya I, Thompson M, et al.. Zanamivir for influenza in adults and children: systematic review of clinical study reports and summary of regulatory comments. BMJ 2014;348:g2547. Context The neuraminidase inhibitor zanamivir, administered as an inhaled powder, is approved for the prevention and treatment of influenza in adults and children older than 7 years. Previous systematic reviews (SRs) of zanamivir may have been affected by publication bias and missing data, and clinical recommendations based on such studies should be considered inadequate.1 2 To deal with these shortcomings, this SR and...
Source: Evidence-Based Medicine - January 21, 2015 Category: Internal Medicine Authors: Michiels, B. Tags: Clinical trials (epidemiology), Immunology (including allergy), Influenza, Otitis, Pneumonia (infectious disease), Vaccination / immunisation, Bronchitis, Pneumonia (respiratory medicine), Ear, nose and throat/otolaryngology Therapeutics/Prevention Source Type: research