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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

The global burden of neurologic diseases
WHO categorizes causes of death and disability into (1) communicable diseases, maternal and perinatal conditions, and nutritional deficiencies; (2) non-communicable diseases (NCD); and (3) injuries. NCD are the leading cause of death and disability globally and are rising as a result of demographic and epidemiologic changes occurring in both developed and developing countries.1,2 Increasing life expectancies, unhealthy diet, physical inactivity, tobacco use, and harmful use of alcohol contribute to the growing incidence and prevalence of NCD, such as heart disease, stroke, diabetes, cancers, and chronic respiratory disease...
Source: Neurology - July 21, 2014 Category: Neurology Authors: Chin, J. H., Vora, N. Tags: All Cerebrovascular disease/Stroke, All epidemiology, All Epilepsy/Seizures GLOBAL PERSPECTIVES Source Type: research

Suboptimal nutrition in moderately preterm infants
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Kelly Brown, Mark J. Johnson, Alison A. Leaf Tags: Short Communication Source Type: research

Re: Tramadol can selectively manage moderate pain in children following European advice limiting codeine use
This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 21, 2014 Category: Pediatrics Authors: Hossein Hassanian‐Moghaddam Tags: Letter Source Type: research

Tiotropium versus placebo for chronic obstructive pulmonary disease.
CONCLUSIONS: This review shows that tiotropium treatment was associated with a significant improvement in patients' quality of life and it reduced the risk of exacerbations, with a number needed to treat to benefit (NNTB) of 16 to prevent one exacerbation. Tiotropium also reduced exacerbations leading to hospitalisation but no significant difference was found for hospitalisation of any cause or mortality. Thus, tiotropium appears to be a reasonable choice for the management of patients with stable COPD, as proposed in guidelines. The trials included in this review showed a difference in the risk of mortality when compared ...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Karner C, Chong J, Poole P Tags: Cochrane Database Syst Rev Source Type: research

Endovascular treatment for ruptured abdominal aortic aneurysm.
CONCLUSIONS: The conclusions of this review are currently limited by the paucity of data. From the data available there is no difference in the outcomes evaluated in this review between eEVAR and open repair, specifically 30-day mortality. Not enough information was provided for complications in order to make a well informed conclusion at this time. Long-term data are lacking for both survival and late complications. More high quality, randomised controlled trials comparing eEVAR and open repair for the treatment of RAAA are needed in order to better understand if one method is superior to the other, or if there is no diff...
Source: Cochrane Database of Systematic Reviews - July 21, 2014 Category: Journals (General) Authors: Badger S, Bedenis R, Blair PH, Ellis P, Kee F, Harkin DW Tags: Cochrane Database Syst Rev Source Type: research

Extracorporeal Life Support in Critically Ill Adults.
Abstract Extracorporeal life support (ECLS) has become increasingly popular as a salvage strategy for critically ill adults. Major advances in technology and the severe acute respiratory distress syndrome (ARDS) that characterized the 2009 influenza A (H1N1) pandemic have stimulated renewed interest in the use of veno-venous extracorporeal membrane oxygenation (ECMO) and extracorporeal carbon dioxide removal (ECCO2R) to support the respiratory system. Theoretical advantages of ECLS for respiratory failure include the ability to rest the lungs by avoiding injurious mechanical ventilator settings and the potential to...
Source: American Journal of Respiratory and Critical Care Medicine - July 21, 2014 Category: Respiratory Medicine Authors: Ventetuolo CE, Muratore CS Tags: Am J Respir Crit Care Med Source Type: research

Sphingobacterium paludis sp. nov., isolated from wetland soil.
Abstract A novel Gram-negative bacteria, designated S37(T), was isolated from soil of the Xixi wetland, Zhejiang province, China. Cells of strain S37(T) were aerobic, non-motile rods. Growth occurred at 10-37 °C (optimum, 25 °C), pH 5.0-9.7 (optimum, pH 7.5) and with 0-6% (w/v) NaCl (optimum, 0.5%). Based on 16S rRNA gene sequence analysis, strain S37(T) was found to be a member of the genus Sphingobacterium and shared highest similarity with S.composti 4M24(T) (95.78%). The major fatty acids were summed feature 3 (iso-C15:0 2-OH and/or C16:1ω7c), iso-C15:0 and iso-C17:0 3-OH and the G+C content was 43.8 mol%. T...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Feng H, Zeng Y, Huang Y Tags: Int J Syst Evol Microbiol Source Type: research

Tangfeifania diversioriginum gen. nov. sp. nov., a novel representative of the family Draconibacteriaceae.
Abstract A novel Gram-stain-negative, facultatively anaerobic, catalase- and oxidase-positive, non-motile and pink pigmented bacterium, designated G22T, was isolated from Gahai, a saltwater lake in Qinghai province, China. Optimal growth occurred at 33-35 °C, pH 7.0-7.5, and in the presence of 2-4% (w/v) of NaCl. The DNA G+C content was 40.0 mol%. The major polar lipids were phosphatidylethanolamine and three unknown lipids. The predominant cellular fatty acids were iso-C15:0, anteiso-C15:0, iso-C17:0 3OH and iso-C15:0 3OH and MK-7 was the main respiratory quinine. Phylogenetic analysis based on 16S rRNA sequences...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Liu QQ, Li XL, Rooney AP, Du ZJ, Chen GJ Tags: Int J Syst Evol Microbiol Source Type: research

Vulgatibacter incomptus gen. nov., sp. nov. and Labilithrix luteola gen. nov., sp. nov., two myxobacteria isolated from soil in Yakushima Island, and the description of Vulgatibacteraceae fam. nov., Labilitrichaceae fam. nov. and Anaeromyxobacteraceae fam. nov.
Abstract Two myxobacterial strains (designated B00001T and B00002T) were isolated from forest soil samples collected from Yakushima Island, Kagoshima, Japan. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strains B00001T and B00002T formed independent branches within the suborder Cystobacterineae and Sorangiineae and were most closely related to Cystobacter armeniaca DSM14710T (90.4%) and Byssovorax cruenta DSM14553T (91.3%), respectively. Neither strain showed typical features of myxobacteria, such as bacteriolytic action or fruiting body formation, but both had high DNA G+C contents (66.3-68...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2014 Category: Microbiology Authors: Yamamoto E, Muramatsu H, Nagai K Tags: Int J Syst Evol Microbiol Source Type: research

Home Ventilation Therapy in Obstructive Sleep Apnea-Hypopnea Syndrome.
Abstract Obstructive sleep apnea-hypopnea is a highly prevalent disease that is often underdiagnosed at present. It has a significant economic and social welfare impact, accounting for a large part of the resources assigned to home respiratory therapies. As part of the 2014 SEPAR Year of the Chronic Patient and Domiciliary Respiratory Care sponsored by the Spanish Society of Pulmonology and Thoracic Surgery, this article reviews the most recent publications on the indications and controversial issues in the treatment of sleep apnea, the latest evidence for indication of various positive pressure devices, and adjust...
Source: Archivos de Bronconeumologia - July 21, 2014 Category: Cardiovascular & Thoracic Surgery Authors: González Mangado N, Troncoso Acevedo MF, Gómez García T Tags: Arch Bronconeumol Source Type: research

Dropsy Outbreak in a Single Family in Punjab, India.
We report an outbreak that is unusual because of its gradual onset, clustering in a single family, and with major manifestation of gastrointestinal illness mimicking acute gastroenteritis, hence leading to delayed diagnosis and high mortality. Thus, the diagnosis of epidemic dropsy should be considered as a strong possibility when there is clustering of cases in a single family with on and off gastrointestinal symptoms of vomiting and diarrhea in a mustard oil consuming belt. PMID: 25048376 [PubMed - as supplied by publisher] (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - July 21, 2014 Category: Tropical Medicine Authors: Pvm L, Sharma A, Bhatia D, Tikoo K, Kumar R Tags: Am J Trop Med Hyg Source Type: research

Testing the role of preBötzinger Complex somatostatin neurons in respiratory and vocal behaviors
Abstract Identifying neurons essential for the generation of breathing and related behaviors such as vocalisation is an important question for human health. The targeted loss of preBötzinger Complex (preBötC) glutamatergic neurons, including those that express high levels of somatostatin protein (SST neurons), eliminates normal breathing in adult rats. Whether preBötC SST neurons represent a functionally specialised population is unknown. We tested the effects on respiratory and vocal behaviors of eliminating SST neuron glutamate release by Cre‐Lox‐mediated genetic ablation of the vesicular glutamate transporter 2 ...
Source: European Journal of Neuroscience - July 20, 2014 Category: Neuroscience Authors: Srinivasan Tupal, Michael A. Rieger, Guang‐Yi Ling, Thomas J. Park, Joseph D. Dougherty, Ann K. Goodchild, Paul A. Gray Tags: Research Report Source Type: research

Motiliproteus sediminis gen. nov., sp. nov., isolated from coastal sediment.
Abstract A novel Gram-stain-negative, rod-to-spiral-shaped, oxidase- and catalase- positive and facultatively aerobic bacterium, designated HS6(T), was isolated from marine sediment of Yellow Sea, China. It can reduce nitrate to nitrite and grow well in marine broth 2216 (MB, Hope Biol-Technology Co., Ltd) with an optimal temperature for growth of 30-33 °C (range 12-45 °C) and in the presence of 2-3 % (w/v) NaCl (range 0.5-7 %, w/v). The pH range for growth was pH 6.2-9.0, with an optimum at 6.5-7.0. Phylogenetic analysis based on 16S rRNA gene sequences demonstrated that the novel isolate was 93.3 % similar...
Source: Antonie van Leeuwenhoek - July 20, 2014 Category: Microbiology Authors: Wang ZJ, Xie ZH, Wang C, Du ZJ, Chen GJ Tags: Antonie Van Leeuwenhoek Source Type: research

Lacinutrix jangbogonensis sp. nov., a psychrophilic bacterium isolated from Antarctic marine sediment and emended description of the genus Lacinutrix.
Abstract A Gram-negative, strictly aerobic, non-motile, rod-shaped and psychrophilic bacterial strain, PAMC 27137(T), was isolated from the marine sediment of the Ross Sea, Antarctica. Strain PAMC 27137(T) was observed to grow at 4-10 °C, at pH 6.5-7.5 and in the presence of 2.5-4.0 % (w/v) sea salts. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that strain PAMC 27137(T) belongs to the genus Lacinutrix showing the high similarities with Lacinutrix mariniflava JCM 13824(T) (97.6 %) and Lacinutrix algicola JCM 13825(T) (97.1 %). Genomic relatedness analyses based on the average nucleotide ...
Source: Antonie van Leeuwenhoek - July 20, 2014 Category: Microbiology Authors: Lee YM, Hwang CY, Lee I, Jung YJ, Cho Y, Baek K, Hong SG, Kim JH, Chun J, Lee HK Tags: Antonie Van Leeuwenhoek Source Type: research

Bacterioplanes sanyensis gen. nov., sp. nov., a PHB-accumulating bacterium isolated from a pool of Spirulina platensis cultivation.
Abstract A Gram-negative, poly-3-hydroxybutyrate-accumulating rod bacterium, strain GYP-2(T), was isolated from a pool of marine Spirulina platensis cultivation, Sanya, China. Growth was observed at 10-45 °C and pH 6-10 in the presence of 1-10 % (w/v) NaCl. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the new isolate belonged to Gammaproteobacteria and displayed 93.8-95.3 % 16S rRNA gene sequences similarities to members of the genera Thalassolituus, Oleibacter, and Oceanobacter, but house-keeping gene gyrB (encode DNA gyrase beta subunit) demonstrated that the new isolate was distantly...
Source: Archives of Microbiology - July 20, 2014 Category: Microbiology Authors: Wang G, Jia Q, Li T, Dai S, Wu H, He H, Fan J, Xiang W, Li X Tags: Arch Microbiol Source Type: research

Oscillating devices for airway clearance in people with cystic fibrosis.
CONCLUSIONS: There was no clear evidence that oscillation was a more or less effective intervention overall than other forms of physiotherapy; furthermore there was no evidence that one device is superior to another. The findings from one study showing an increase in frequency of exacerbations requiring antibiotics whilst using an oscillating device compared to positive expiratory pressure may have significant resource implications. More adequately-powered long-term randomised controlled trials are necessary and outcomes measured should include frequency of exacerbations, patient preference, adherence to therapy and genera...
Source: Cochrane Database of Systematic Reviews - July 20, 2014 Category: Journals (General) Authors: Morrison L, Agnew J Tags: Cochrane Database Syst Rev Source Type: research

Genetic Characterization and Evolution of H1N1pdm09 after Circulation in a Swine Farm.
In this study we investigated the molecular evolution of A(H1N1)pdm09 virus identified in pigs reared in a single herd. Nasal swabs taken from pigs showing respiratory distress were tested for influenza type A and A(H1N1)pdm09 by real-time RT-PCR assays. Virus isolation from positive samples was attempted by inoculation of nasal swabs samples into specific pathogen free embryonated chicken eggs (ECE) and complete genome sequencing was performed on virus strains after replication on ECE or from original swab sample. The molecular analysis of hemagglutinin (HA) showed, in four of the swine influenza viruses under study, a un...
Source: Biomed Res - July 19, 2014 Category: Research Authors: Boni A, Vaccari G, Di Trani L, Zaccaria G, Alborali GL, Lelli D, Cordioli P, Moreno AM Tags: Biomed Res Int Source Type: research

Efficacy of Burnout Interventions in the Medical Education Pipeline.
CONCLUSIONS: There is a growing body of evidence-based interventions to mitigate burnout which can be used in the development of future programs. More research is needed to identify and intervene against burnout earlier in the medical education pipeline, including at the undergraduate level. PMID: 25034955 [PubMed - as supplied by publisher] (Source: The Journal of American Association of Directors of Psychiatric Residency Training)
Source: The Journal of American Association of Directors of Psychiatric Residency Training - July 19, 2014 Category: Psychiatry Tags: Acad Psychiatry Source Type: research

Is there a rationale and role for long-acting anticholinergic bronchodilators in asthma?
Abstract Despite current guidelines and the range of available treatments, over a half of patients with asthma continue to suffer from poor symptomatic control and remain at risk of future worsening. Although a number of non-pharmacological measures are crucial for good clinical management of asthma, new therapeutic controller medications will have a role in the future management of the disease. Several long-acting anticholinergic bronchodilators are under investigation or are available for the treatment of respiratory diseases, including tiotropium bromide, aclidinium bromide, glycopyrronium bromide, glycopyrrolat...
Source: Primary Care - July 19, 2014 Category: Primary Care Authors: Price D, Fromer L, Kaplan A, van der Molen T, Román-Rodríguez M Tags: NPJ Prim Care Respir Med Source Type: research

Maternal protein restriction alters VEGF signaling and decreases pulmonary alveolar in fetal rats.
In this study, we investigated the effects of protein malnutrition in utero on pulmonary alveolarization and vascular growth of the fetal lung and placentae. Pregnant rats were feed with an isocaloric low-protein diet (8% protein) until delivery. Placenta and fetal lungs were harvested on 20th day of gestation (term 21 days of gestation). Lung index (lung weight as a percentage of body weight), total DNA and protein, radial alveolar count, arteriolar wall thickness, lung maturity and angiogenic factor VEGF were assessed. The lung was hypoplastic in IUGR fetus, evidenced by reduction in lung weight, DNA and protein content....
Source: International Journal of Clinical and Experimental Pathology - July 19, 2014 Category: Pathology Authors: Liu X, Lin Y, Tian B, Miao J, Xi C, Liu C Tags: Int J Clin Exp Pathol Source Type: research

Gamma glutamyltransferase, alanine aminotransferase and risk of cancer: Systematic review and meta‐analysis
Abstract The prospective evidence for the associations of gamma glutamyltransferase (GGT) and alanine aminotransferase (ALT) with risk of cancer in the general population is uncertain. We conducted a systematic review and meta‐analysis of published prospective observational studies evaluating the associations of baseline levels of GGT and ALT with risk of overall (incidence and/or mortality) and site‐specific cancers. Relevant studies were identified in a literature search of MEDLINE, EMBASE, Web of Science, reference lists of relevant studies to April 2014, and email contact with investigators. Study specific relative...
Source: International Journal of Cancer - July 19, 2014 Category: Cancer & Oncology Authors: Setor K. Kunutsor, Tanefa A. Apekey, Mieke Van Hemelrijck, Giliola Calori, Gianluca Perseghin Tags: Epidemiology Source Type: research

Long-acting beta-agonists plus inhaled corticosteroids safety: a systematic review and meta-analysis of non-randomized studies
Conclusions: Evidence from observational studies shows that the combined treatment of LABAs and ICs is not associated with a higher risk of serious adverse events, compared to ICs alone. Major gaps identified were prospective design, paediatric population and inclusion of mortality as a primary outcome. (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2014 Category: Respiratory Medicine Authors: Gimena HernándezMónica AvilaÀngels PontOlatz GarinJordi AlonsoLaurent LaforestChristopher CatesMontserrat Ferrer Source Type: research

Fluticasone propionate/formoterol: A fixed-combination therapy with flexible dosage.
Abstract International guidelines describe asthma control as the main outcome of asthma management. Prevention of symptoms, improved quality of life, and reduction of exacerbations are the main components, consequently decreasing health care costs. However, many of these objectives remain unmet in real life: several surveys show that a large proportion of asthmatic patients are not well controlled despite the efficacy of current available treatment. Several randomized controlled clinical trials indicate that combining inhaled corticosteroids and long-acting β2-agonists, by means of a single inhaler, greatly improv...
Source: European Journal of Internal Medicine - July 19, 2014 Category: Internal Medicine Authors: Papi A, Blasi F, Canonica GW, Cazzola M, Centanni S, Foschino Barbaro MP, Melani AS, Paggiaro P, Ricciardolo F, Rossi A, Scichilone N Tags: Eur J Intern Med Source Type: research

Concomitant sensitization to ragweed and mugwort pollen: who is who in clinical allergy?
CONCLUSION: This study found that Art v 6 plays an important role in mugwort allergy and that the cross-reactivity between Art v 6 and Amb a 1 is frequent, bidirectional, and clinically relevant in the area of Milan. PMID: 25053399 [PubMed - as supplied by publisher] (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - July 19, 2014 Category: Allergy & Immunology Authors: Asero R, Bellotto E, Ghiani A, Aina R, Villalta D, Citterio S Tags: Ann Allergy Asthma Immunol Source Type: research

Medical consensus, guidelines, and position papers: A policy for the ECFS
The terms consensus, guideline and position paper are sometimes employed as if they were interchangeable, but the purpose of such documents and the robustness of advice vary as the evidence base does not have the same depth in each. The Board of the European Cystic Fibrosis Society deemed it to be helpful to provide a short commentary on the definition of these terms, on their interconnections and on how ECFS considers them in documents endorsed by the society. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 19, 2014 Category: Respiratory Medicine Authors: K. De Boeck, C. Castellani, J.S. Elborn, On behalf of the ECFS Board Source Type: research

Computed tomography correlates with improvement with ivacaftor in cystic fibrosis patients with G551D mutation
Ivacaftor corrects the cystic fibrosis transmembrane conductance regulator (CFTR) gating defect associated with G551D mutation and is quickly becoming an important treatment in patients with cystic fibrosis (CF) due to this genetic mutation. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 19, 2014 Category: Respiratory Medicine Authors: Shahid I. Sheikh, Frederick R. Long, Karen S. McCoy, Terri Johnson, Nancy A. Ryan-Wenger, Don Hayes Source Type: research

Evaluation of respiratory impairment in patients with systemic lupus erythematosus with the six-minute walk test
Conclusion: Compared to 6MWD, desaturation was better suited to find the patients with the most compromised indexes in respiratory function tests. (Source: Revista Brasileira de Reumatologia)
Source: Revista Brasileira de Reumatologia - July 18, 2014 Category: Rheumatology Source Type: research

IgA nephropathy and polymyositis: a rare association
A polimiosite é uma miopatia inflamatória idiopática sistêmica que, além da manifestação muscular, pode eventualmente cursar com acometimento respiratório, do trato gastrintestinal e, raramente, renal. Neste último caso, há descrição de apenas dois casos de nefropatia por IgA em pacientes com miopatia, ambos em dermatomiosite. Em contrapartida, relatamos pela primeira vez esta rara associação em polimiosite.Polymyositis is a systemic and idiopathic inflammatory myopathy that, besides muscle manifestation, may occur with respiratory involvement, gastrointestinal tract and rarely renal involvement. In this latt...
Source: Revista Brasileira de Reumatologia - July 18, 2014 Category: Rheumatology Source Type: research

Duchenne and Becker Muscular Dystrophies
The dystrophinopathies Duchenne and Becker muscular dystrophies (DMD and BMD) represent the most common inherited disorders of muscle. Improvements in cardiac care, attention to respiratory function, and judicious use of spinal correction surgery have led to increased survival in the DMD population. Meanwhile, advances in molecular therapeutics have led to promising therapies that are in or are entering clinical trials. An understanding of the dystrophinopathies, and recent advances in their molecular diagnosis and treatment, is of benefit to practicing neurologists. (Source: Neurologic Clinics)
Source: Neurologic Clinics - July 18, 2014 Category: Neurology Authors: Kevin M. Flanigan Source Type: research

Glycopyrrolate for treatment of clozapine-induced sialorrhea in adults.
CONCLUSION: Glycopyrrolate was effective in alleviating symptoms in three of four patients with CIS. In a fourth patient, the degree of improvement was unknown due to documentation discrepancies; however, mild improvement was noted initially. PMID: 25027535 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - July 18, 2014 Category: Drugs & Pharmacology Authors: Blissit KT, Tillery E, Latham C, Pacheco-Perez J Tags: Am J Health Syst Pharm Source Type: research

Acknowledging problems can be a solution
Mary Merrell, the CEO of Ambercare Home Health Care, helped begin the company more than 15 years ago. Ambercare offers home and hospice care, as well as physical, respiratory and occupational therapy. It also provides medical supplies and equipment to patients and their families. When did you know you wanted to pursue the career you are in now? I knew I wanted to be a nurse as a little girl, maybe around nine years old. Even though I didn’t become a nurse until I was in my thirties, it always… (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - July 18, 2014 Category: Hospital Management Authors: Hunter Riley | Special to Albuquerque Business First Source Type: research

Audit review of the appropriateness of integrated COPD management: the "ALT-COPD" project
Conclusions: It is easier to resolve the gaps in specialist clinical practice than the organizational gaps, changing which is the politicians' task. Correcting specialists' inappropriateness may be worthless if this is not accompanied by improvement of the organizational obstacles. The search for appropriateness should not be limited only to specialists or to a strict control of drug prescription but should include all the organizational aspects. Implementation of COPD-GL calls for actions on the part of both specialists and the health system. (Source: BioMed Central)
Source: BioMed Central - July 18, 2014 Category: Journals (General) Authors: Stefano NardiniGaetano CicchittoFernando De BenedettoClaudio F DonnerMario PolverinoClaudio M SanguinettiAlberto Visconti Source Type: research

Utility of fluorodeoxyglucose positron emission tomography/computed tomography for early diagnosis and evaluation of disease activity of relapsing polychondritis: a case series and literature review
Conclusion. FDG-PET/CT is a potentially powerful tool for the early diagnosis of RPC, especially in patients without easily biopsied organ involvement. This modality also facilitates evaluation of disease extent and disease activity during treatment. (Source: Rheumatology)
Source: Rheumatology - July 18, 2014 Category: Rheumatology Authors: Yamashita, H., Takahashi, H., Kubota, K., Ueda, Y., Ozaki, T., Yorifuji, H., Bannai, E., Minamimoto, R., Morooka, M., Miyata, Y., Okasaki, M., Takahashi, Y., Kaneko, H., Kano, T., Mimori, A. Tags: Osteoarthritis and Cartilage, Diagnostics and Imaging Procedures CLINICAL SCIENCE Source Type: research

Topical antibiotic therapy is superior to systemic antibiotics for acute tympanostomy tube otorrhoea, but may not be necessary for all children
Commentary on: van Dongen TMA, van der Heijden GJMG, Venekamp RP, et al.. A trial of treatment for acute otorrhea in children with tympanostomy tubes. N Engl J Med 2014;370:723–33. Context Tympanostomy tube insertion is the most common ambulatory surgery performed on children.1 Discharge from the ear canal (otorrhoea) is the most common sequela of tubes, with a mean incidence of 26% in observational studies and up to 83% with prospective surveillance.2 3 Acute tympanostomy tube otorrhoea (TTO) is usually a manifestation of acute otitis media and may occur during a viral upper respiratory infection or when water penet...
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Rosenfeld, R. M. Tags: Clinical trials (epidemiology), Genetics, Otitis, Drugs: CNS (not psychiatric), Chemotherapy, Connective tissue disease, Ear, nose and throat/otolaryngology Therapeutics Source Type: research

Omalizumab decreases exacerbations and allows a step down in daily inhaled corticosteroid dose in adults and children with moderate-to-severe asthma
Commentary on: Normansell R, Walker S, Milan SJ, et al.. Omalizumab for asthma in adults and children. Cochrane Database Syst Rev 2014;1:CD003559. Context Asthma is a common chronic disease that affects over 300 million people worldwide. Between 5% and 10% of this population has severe asthma, which often remains uncontrolled despite maximal conventional treatment. Omalizumab is a recombinant humanised monoclonal antibody that binds circulating IgE antibody and decreases allergic, IgE-mediated airway inflammation.1 In the USA and many other countries, omalizumab is approved for the treatment of adults and adolescents aged ...
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Thomson, N. C. Tags: Clinical trials (epidemiology), Immunology (including allergy), Asthma, Drugs: respiratory system Therapeutics Source Type: research

Voided midstream urine culture is a good test for acute cystitis in premenopausal women
Commentary on: Hooton TM, Roberts PL, Cox ME, et al.. Voided midstream urine culture and acute cystitis in premenopausal women. N Engl J Med 2013;369:1883–91. Context Uncomplicated acute cystitis is a common and uncomfortable condition in premenopausal women. Controversy exists over the value of culture data obtained from clean-catch midstream urine specimens for directing antimicrobial therapy, due to the risk of contamination by periurethral and vaginal organisms affecting the detection of true bladder bacteriuria. In the past, bacterial colony counts have been used to determine the threshold for clinically meaning...
Source: Evidence-Based Medicine - July 18, 2014 Category: Internal Medicine Authors: Cox, L., Clemens, J. Q. Tags: EBM Diagnosis, Pneumonia (infectious disease), Urinary tract infections, Menopause (including HRT), Pneumonia (respiratory medicine), Vulvovaginal disorders, Urinary tract infections Source Type: research

Shisa3 Associated with Prolonged Survival through Promoting β-catenin Degradation in Lung Cancer.
Conclusions: Our results reveal that Shisa3 acts as a tumor suppressor by acceleration of β-catenin degradation and provide a new insight for cancer prognosis and therapy. PMID: 25036006 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 18, 2014 Category: Respiratory Medicine Authors: Chen CC, Chen HY, Su KY, Hong QS, Yan BS, Chen CH, Pan SH, Chang YL, Wang CJ, Hung PF, Yuan SS, Chang GC, Chen JJ, Yang PC, Yang YC, Yu SL Tags: Am J Respir Crit Care Med Source Type: research

The impact of aging on adipose structure, function, and vasculature in the B6D2F1 mouse: Evidence of significant multisystem dysfunction.
This article is protected by copyright. All rights reserved. PMID: 25038241 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 18, 2014 Category: Physiology Authors: Donato AJ, Henson GD, Hart CR, Layec G, Trinity JD, Bramwell RC, Enz RA, Morgan RG, Reihl KD, Hazra S, Walker AE, Richardson RS, Lesniewski LA Tags: J Physiol Source Type: research

Mitochondrial flashes: new insights into mitochondrial ROS signaling and beyond.
This article is protected by copyright. All rights reserved. PMID: 25038239 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 18, 2014 Category: Physiology Authors: Hou T, Wang X, Ma Q, Cheng H Tags: J Physiol Source Type: research

A prospective 10-year follow-up polygraphic study of patients treated with a mandibular protruding device.
CONCLUSIONS: MPD treatment is well tolerated and effective in a long-term, 10-year perspective. Weight gain may jeopardize MPD effects. Both patients and relatives reported significantly less snoring and fewer periods of apnea. PMID: 25034825 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 18, 2014 Category: Sleep Medicine Authors: Wiman Eriksson E, Leissner L, Isacsson G, Fransson A Tags: Sleep Breath Source Type: research

Post Exposure Aerosolized Heparin Reduces Lung Injury in Chlorine Exposed Mice.
In this study, we tested the hypothesis that exposure of mice to Cl2 causes intra-alveolar and systemic activation of the coagulation cascade that plays an important role in development of lung injury. C57BL/6 mice were exposed to Cl2 (400 or 600 ppm) in environmental chambers and then returned to room air for 1 or 6 h. Native coagulation (NATEM) parameters such as blood clotting time and clot formation time were measured in whole blood by viscoelastic technique. D-Dimers and thrombin-anti-thrombin complexes were measured in both plasma and Bronchoalveolar Lavage Fluid (BALF) by ELISA. Our results indicate that mice expose...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 18, 2014 Category: Cytology Authors: Zarogiannis SG, Wagener BM, Basappa SN, Doran SF, Rodriguez CA, Jurkuvenaite A, Pittet JF, Matalon S Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Influenza causes prolonged disruption of the alveolar-capillary barrier in mice unresponsive to mesenchymal stem cell therapy.
We report that influenza induces marked, long-lasting dysfunction of the alveolar-capillary barrier peaking at one week but lasting longer than 3 weeks post-infection. Weight loss, commonly employed as a criterion for euthanasia (and hence "survival") was found to be poorly predictive of the severity of lung injury at its peak; rather, persistent weight loss 11 days post-infection identified mice with impaired injury resolution. Murine and human bone-marrow derived MSCs (obtained from the NIH repository) were then administered intravenously during the rapid phase of injury progression. Murine MSCs (mMSCs) given twice 24 ho...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - July 18, 2014 Category: Cytology Authors: Gotts JE, Abbott J, Matthay MA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Respiratory Bronchiolitis With Fibrosis-Interstitial Lung Disease: A New Form of Smoking-Induced Interstitial Lung Disease.
Abstract The recent pathology literature has described a new form of localized interstitial fibrosis associated with heavy cigarette smoking. This lesion has been referred to by various names, including respiratory bronchiolitis-interstitial lung disease with fibrosis,(1) airspace enlargement with fibrosis,(2) and smoking-related interstitial fibrosis.(3) We have suggested that, to avoid confusion with other forms of smoking-related interstitial lung disease (ILD), the lesion be referred to as respiratory bronchiolitis with fibrosis (RBF).(4) Most importantly, we have found that this pathologic abnormality often ha...
Source: Archives of Pathology and Laboratory Medicine - July 18, 2014 Category: Laboratory Medicine Authors: Churg A, Hall R, Bilawich A Tags: Arch Pathol Lab Med Source Type: research

Acute respiratory distress syndrome in a patient with primary myelofibrosis after ruxolitinib treatment discontinuation.
We present a case of a 76-year-old man diagnosed with primary myelofibrosis who presented with constitutional symptoms and symptomatic splenomegaly. Ruxolitinib was started (15 mg twice daily) and his disease-related symptoms disappeared. Six weeks later, he developed grade 4 thrombocytopenia and grade 3 anemia. Ruxolitinib was stopped and corticosteroid treatment (prednisone 1 mg/kg/day) was started to avoid a cytokine-rebound reaction. The patient then developed fever, chills, a biological inflammatory syndrome, and an acute respiratory disease syndrome. Full workup excluded an infection and we concluded that ruxolitin...
Source: International Journal of Hematology - July 18, 2014 Category: Hematology Authors: Beauverd Y, Samii K Tags: Int J Hematol Source Type: research

Effects of therapeutic approach on the neonatal evolution of very low birth weight infants with patent ductus arteriosus.
CONCLUSION: the conservative approach of PDA was associated to high mortality, the surgical approach to the occurrence of BPD36wks and ROPsur, and the pharmacological treatment was protective for the outcome death/BPD36wks. PMID: 25046256 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - July 18, 2014 Category: Pediatrics Authors: Sadeck LS, Leone CR, Procianoy RS, Guinsburg R, Marba ST, Martinez FE, Rugolo LM, Moreira ME, Fiori RM, Ferrari LL, Menezes JA, Venzon PS, Abdallah VQ, Duarte JL, Nunes MV, Anchieta LM, Filho NA Tags: J Pediatr (Rio J) Source Type: research

Treating patients with real-time tumor tracking using the Vero gimbaled linac system: Implementation and first review.
CONCLUSION: A considerable PTV volume reduction was achieved applying RTTT and time efficiency for respiratory correlated SBRT was reestablished with Vero RTTT. PMID: 25049177 [PubMed - as supplied by publisher] (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 18, 2014 Category: Radiology Authors: Depuydt T, Poels K, Verellen D, Engels B, Collen C, Buleteanu M, Van den Begin R, Boussaer M, Duchateau M, Gevaert T, Storme G, De Ridder M Tags: Radiother Oncol Source Type: research

Genetic Variation of human respiratory syncytial virus among children with fever and respiratory symptoms in Shanghai, China, from 2009 to 2012.
Abstract Human respiratory syncytial virus (HRSV) of genus Pneumovirus is one of the most common pathogens causing severe acute lower respiratory tract infection in infants and children. No information on the genotype distribution of HRSV is available in East China (e.g. Shanghai). From August 2009 to December 2012, 2407 nasopharyngeal swabs were collected from outpatient children with fever and respiratory symptoms in Shanghai. HRSV infection was determined using a multiplex RT-PCR assay. The second hypervariable region (HVR2) of G protein gene of HRSV was amplified and sequenced from HRSV positive samples. Genoty...
Source: Infection, Genetics and Evolution - July 18, 2014 Category: Genetics & Stem Cells Authors: Liu J, Mu Y, Dong W, Yao F, Wang L, Yan H, Lan K, Zhang C Tags: Infect Genet Evol Source Type: research