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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

In search of the elusive lipofibroblast in human lungs
Although the pulmonary interstitial lipofibroblast (LF) has been widely recognized in rat and mouse lungs, their presence in human lungs remains controversial. In a recent issue of the Journal, Tahedl and associates (Tahedl D, Wirkes A, Tschanz SA, Ochs M, Mühlfeld C. Am J Physiol Lung Cell Mol Physiol 307: L386–L394, 2014) address this controversy and provide the most detailed stereological analysis of LFs in mammals other than rodents. Strikingly, their observations demonstrate that LFs were only observed in rodents, which contrasts with earlier reports. This editorial reviews the anatomical, physiological, an...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Ahlbrecht, K., McGowan, S. E. Tags: EDITORIAL FOCUS Source Type: research

Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency
Epithelial sodium channels (ENaC) govern transepithelial salt and fluid homeostasis. ENaC contributes to polarization, apoptosis, epithelial-mesenchymal transformation, etc. Fibrinolytic proteases play a crucial role in virtually all of these processes and are elaborated by the airway epithelium. We hypothesized that urokinase-like plasminogen activator (uPA) regulates ENaC function in airway epithelial cells and tested that possibility in primary murine tracheal epithelial cells (MTE). Both basal and cAMP-activated Na+ flow through ENaC were significantly reduced in monolayers of uPA-deficient cells. The reduction in ENaC...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Chen, Z., Zhao, R., Zhao, M., Liang, X., Bhattarai, D., Dhiman, R., Shetty, S., Idell, S., Ji, H.-L. Tags: ARTICLES Source Type: research

Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice
Signaling through platelet-derived growth factor receptor-α (PDGFRα) is required for alveolar septation and participates in alveolar regeneration after pneumonectomy. In both adipose tissue and skeletal muscle, bipotent pdgfrα-expressing progenitors expressing delta-like ligand-1 or sex-determining region Y box 9 (Sox9) may differentiate into either lipid storage cells or myofibroblasts. We analyzed markers of mesenchymal progenitors and differentiation in lung fibroblasts (LF) with different levels (absent, low, or high) of pdgfrα gene expression. A larger proportion of pdgfrα-expressing than...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: McGowan, S. E., McCoy, D. M. Tags: ARTICLES Source Type: research

MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix
We examined whether aberrantly low FoxO3a expression is in part due to increased miR-96 levels in IPF fibroblasts on polymerized collagen, thereby causing IPF fibroblasts to maintain their pathological properties. miR-96 expression was upregulated in IPF fibroblasts compared with control fibroblasts when cultured on collagen. In contrast, FoxO3a mRNA levels were reduced in most IPF fibroblasts. However, when miR-96 function was inhibited, FoxO3a mRNA and protein expression were increased, suppressing IPF fibroblast proliferation and promoting their cell death in a dose-dependent fashion. Likewise, FoxO3a and its target pro...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Nho, R. S., Im, J., Ho, Y.-Y., Hergert, P. Tags: ARTICLES Source Type: research

cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells
Lung injury caused by inhalation of dust from swine-concentrated animal-feeding operations (CAFO) involves the release of inflammatory cytokine interleukin 8 (IL-8), which is mediated by protein kinase C- (PKC-) in airway epithelial cells. Once activated by CAFO dust, PKC- is responsible for slowing cilia beating and reducing cell migration for wound repair. Conversely, the cAMP-dependent protein kinase (PKA) stimulates contrasting effects, such as increased cilia beating and an acceleration of cell migration for wound repair. We hypothesized that a bidirectional mechanism involving PKA and PKC regulates epithelial airway ...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Wyatt, T. A., Poole, J. A., Nordgren, T. M., DeVasure, J. M., Heires, A. J., Bailey, K. L., Romberger, D. J. Tags: ARTICLES Source Type: research

Role of MMP2 and MMP9 in TRPV4-induced lung injury
In this study, we tested the hypothesis that TRPV4 activation provides a Ca2+ source necessary for proteolytic disruption of cell-cell or cell-matrix adhesion by matrix metalloproteinases (MMPs) 2 and 9, thus increasing septal barrier permeability. In our study, C57BL/6 or TRPV4–/– mouse lungs were perfused with varying doses of the TRPV4 agonist GSK-1016790A (Sigma) and then prepared for Western blot. Lung injury, assessed by increases in lung wet-to-dry weight ratios and total protein levels in the bronchoalveolar lavage fluid, was increased in a dose-dependent fashion in TRPV4+/+ but not TRPV4–/–...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Villalta, P. C., Rocic, P., Townsley, M. I. Tags: ARTICLES Source Type: research

Targeting MARCKS Phosphorylation Site Domain in Lung Cancer: Mechanisms and Therapeutic Implications.
Conclusions: These results suggest a key role for MARCKS PSD in cancer disease and provide a unique strategy for inhibiting the activity of MARCKS PSD as a treatment for lung cancer. PMID: 25318062 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R Tags: Am J Respir Crit Care Med Source Type: research

Non-Invasive Saliva-Based EGFR Gene Mutation Detection in Lung Cancer Patients.
Conclusions: Our data indicate that EFIRM is effective, accurate, rapid, user-friendly, and cost-effective for the detection of EGFR mutations in the saliva of NSCLC patients. We termed this SAliva-Based EGFR (SABER) mutation detection. PMID: 25317990 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Wei F, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT Tags: Am J Respir Crit Care Med Source Type: research

Heartbeat Evoked Potentials During Sleep and Daytime Behavior in Children with Sleep Disordered Breathing.
Conclusion: Children with SDB displayed reduced HEP amplitude during sleep, which might be indicative of changes in afferent sensory inputs to the brain and/ or signify differences in sensory gating of cardiac-related information in the insular cortex. Adenotonsillectomy appears to reverse this effect. PMID: 25317937 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Immanuel SA, Pamula Y, Kohler M, Martin J, Kennedy D, Nalivaiko E, Saint DA, Baumert M Tags: Am J Respir Crit Care Med Source Type: research

Using Your Metered Dose Inhaler (MDI).
Authors: PMID: 25317475 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Flip-flop lung. An unusual etiology of bronchiectasis.
PMID: 25317474 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Liptzin DR, Fan LL, Stillwell PC, Dannull KA, Fadell MF, Partrick DA, Dishop MK Tags: Am J Respir Crit Care Med Source Type: research

Invasive endobronchial mucormycosis.
PMID: 25317473 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Ferrell BA, Tolle JJ Tags: Am J Respir Crit Care Med Source Type: research

Reply: the respiratory extracorporeal membrane oxygenation survival prediction score: several potential roles in our bedside practice in intensive care.
PMID: 25317472 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Schmidt M, Pilcher D Tags: Am J Respir Crit Care Med Source Type: research

Reply: cumulative radiation exposure to abdominal organs in patients with cystic fibrosis should not be forgotten.
PMID: 25317471 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Kuo W, Ciet P, Tiddens H, Zhang W, Guillerman RP, van Straten M Tags: Am J Respir Crit Care Med Source Type: research

Respite from the RESP Score.
PMID: 25317470 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Senussi MH Tags: Am J Respir Crit Care Med Source Type: research

Cumulative radiation exposure to abdominal organs in patients with cystic fibrosis should not be forgotten.
PMID: 25317469 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Murphy KP, O'Connell OJ, O'Connor OJ, Plant BJ, Maher MM Tags: Am J Respir Crit Care Med Source Type: research

Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea.
PMID: 25317468 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D Tags: Am J Respir Crit Care Med Source Type: research

Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.
PMID: 25317467 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG Tags: Am J Respir Crit Care Med Source Type: research

Bronchial and systemic inflammation in morbidly obese subjects with asthma: a biopsy study.
PMID: 25317466 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: van Huisstede A, Rudolphus A, van Schadewijk A, Cabezas MC, Mannaerts GH, Taube C, Hiemstra PS, Braunstahl GJ Tags: Am J Respir Crit Care Med Source Type: research

Three-Dimensional Modeled Custom-made Noninvasive Positive Pressure Ventilation Masks in an Infant.
PMID: 25317465 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Carroll A, Amirav I, Marchand R, Olmstead D, Logan H, Grosvenor A, Majaesic C, MacLean J, Mandhane PJ Tags: Am J Respir Crit Care Med Source Type: research

Bosentan for Sarcoidosis-associated Pulmonary Hypertension, Age-adjusted D-Dimer Levels in Pulmonary Embolism, and Mean Arterial Blood Pressure Targets in Septic Shock.
PMID: 25317464 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Alvarez RA, Barbash IJ, Rose JJ Tags: Am J Respir Crit Care Med Source Type: research

Obesity-related Ventilatory Phenotypes of Sleep-disordered Breathing.
PMID: 25317463 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Kirkness JP Tags: Am J Respir Crit Care Med Source Type: research

The Lung Microbiome in Idiopathic Pulmonary Fibrosis. What Does It Mean and What Should We Do about It?
PMID: 25317462 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Morris A, Gibson K, Collman RG Tags: Am J Respir Crit Care Med Source Type: research

Lipoxins and epoxyeicosatrienoic acids. Potential for inhibitors of soluble epoxide hydrolase in severe asthma?
PMID: 25317461 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Chung KF Tags: Am J Respir Crit Care Med Source Type: research

Groundhog day: airway narrowing, deep inspirations, and asthma.
PMID: 25317460 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Brown RH Tags: Am J Respir Crit Care Med Source Type: research

Defective Innate Immunity and Hyper-Inflammation in Newborn CFTR-Knockout Ferret Lungs.
Abstract Mucociliary clearance (MCC) and submucosal glands (SMGs) are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although both of these defense systems develop post-natally in the ferret, the lungs of newborn ferrets remain sterile in the presence of a functioning cystic fibrosis transmembrane conductance regulator (CFTR) gene. We evaluated several components of airway innate immunity and inflammation in the early CF ferret lung. At birth, the rates of MCC did not differ between CF and non-CF animals, but the height of the airway surface liquid was significantly ...
Source: Am J Respir Cell Mol... - October 15, 2014 Category: Respiratory Medicine Authors: Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF Tags: Am J Respir Cell Mol Biol Source Type: research

SHP2 and FAK Protein Interactions Regulate Pulmonary Endothelium Barrier Function.
Abstract Enhanced protein tyrosine phosphorylation (PTP) is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the PTP, SHP2, increases tyrosine phosphorylation of VE-cadherin and β-catenin, resulting in disruption of the endothelial monolayer and edema formation in the pulmonary endothelium. Vascular permeability is a hallmark of acute lung injury (ALI), thus enhanced SHP2 activity offers potential therapeutic value for the pulmonary vasculature in diseases such as ALI; however this has not been character...
Source: Am J Respir Cell Mol... - October 15, 2014 Category: Respiratory Medicine Authors: Chichger H, Braza J, Duong H, Harrington EO Tags: Am J Respir Cell Mol Biol Source Type: research

Muscle Weakness and Speech in Oculopharyngeal Muscular Dystrophy.
Conclusions: Despite having less than half the maximal tongue strength of healthy controls, the individuals with OPMD exhibited minimal speech deficits. The threshold of weakness required for noticeable speech impairment may not have been reached by this group of adults with OPMD. PMID: 25321879 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - October 15, 2014 Category: Speech Therapy Authors: Neel AT, Palmer PM, Sprouls G, Morrison L Tags: J Speech Lang Hear Res Source Type: research

Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats.
Abstract In addition to the amount of ingested calories, both timing of food intake and meal composition are determinants of body weight gain. However, at present, it is unknown if the inappropriate timing of diet components is responsible for body weight gain. In the present study, we therefore studied a time-dependent effect of the diet composition on energy homeostasis. Male Wistar rats were subjected to chow ad libitum (chow group) or a choice diet with saturated fat, a 30% sugar solution, chow and tap water. The choice diet was provided either with all components ad libitum (AL), with ad libitum access to chow...
Source: Chronobiology International - October 15, 2014 Category: Biology Authors: Oosterman JE, Foppen E, van der Spek R, Fliers E, Kalsbeek A, la Fleur SE Tags: Chronobiol Int Source Type: research

Inefficient transmissibility of NS-truncated H3N8 equine influenza virus in dogs.
Abstract H3N8 Equine influenza virus (EIV) causes respiratory diseases in horse population, and it has been demonstrated that EIV can transmit into dogs due to its availability on receptors of canine respiratory epithelial cells. Recently, we isolated H3N8 EIV from EIV vaccinated horse that showed symptoms of respiratory disease, and which has partially truncated nonstructural gene (NS). However, it is not clear that the NS-truncated EIV has an ability to cross the host species barrier from horses to dogs as well. Here, we experimentally infect the NS-truncated H3N8 EIV into dogs, and monitored their clinical signs...
Source: Journal of Microbiology and Biotechnology - October 15, 2014 Category: Biotechnology Authors: Na W, Song M, Yeom M, Park N, Kang B, Moon H, Jeong DG, Kim JK, Song D Tags: J Microbiol Biotechnol Source Type: research

Proposal of Novosphingobium rhizosphaerae sp. nov., isolated from the rhizosphere.
Abstract A yellow pigmented, Gram-negative, rod-shaped, non-spore-forming bacterium (strain JM-1T), was isolated from the rhizosphere of a field-grown Zea mays plant in Auburn, Alabama, U.S.A. The 16S rRNA gene sequence analysis of strain JM-1T showed high sequence similarity to the type strains of Novosphingobium capsulatum (98.9%), Novosphingobium aromaticivorans (97.4%), Novosphingobium subterraneum (97.3%), and Novosphingobium taihuense (97.1%), sequence similarities to all other Novosphingobium species type strains were below 97.0%. DNA-DNA hybridizations of strain JM-1T and N. capsulatum DSM 30196T, N. aromat...
Source: International Journal of Systematic and Evolutionary Microbiology - October 15, 2014 Category: Microbiology Authors: Kämpfer P, Martin K, McInroy JA, Glaeser SP Tags: Int J Syst Evol Microbiol Source Type: research