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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Bronchial chloroma.
PMID: 25025362 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Faiz SA, Ordonez NG, Morice RC, Bashoura L, Jimenez CA Tags: Am J Respir Crit Care Med Source Type: research

Vertebral erosion: an uncommon complication of tracheal tubes.
PMID: 25025361 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Petrache I, Patel D, Wolf KM, Winer-Muram H Tags: Am J Respir Crit Care Med Source Type: research

Reply: Practice Guideline for Pulmonary Hypertension in Sickle Cell: Direct Evidence Needed before Universal Adoption.
PMID: 25025360 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Klings ES, Machado RF, Morris CR, Gordeuk VR, Kato GJ, Ataga KI, Castro O, Hsu L, Telen MJ, Krishnamurti L, Steinberg MH, Gladwin MT, ATS Clinical Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease Committee Tags: Am J Respir Crit Care Med Source Type: research

Practice Guideline for Pulmonary Hypertension in Sickle Cell: Direct Evidence Needed before Universal Adoption.
PMID: 25025359 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Hassell KL, Afenyi-Annan A, Ballas SK, Buchanan GR, Eckman JR, Jordan L, Lanzkron S, Lottenberg R, Ware R Tags: Am J Respir Crit Care Med Source Type: research

Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter.
PMID: 25025358 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Alexis NE, Huang YC, Rappold AG, Kehrl H, Devlin R, Peden DB Tags: Am J Respir Crit Care Med Source Type: research

Inferior vena cava diameter may be misleading in detecting central venous pressure elevation induced by acute pulmonary hypertension.
PMID: 25025357 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Bouzat P, Walther G, Rupp T, Levy P, Vergès S Tags: Am J Respir Crit Care Med Source Type: research

Nuclear Magnetic Resonance-based Metabolomics Discriminates Primary Ciliary Dyskinesia from Cystic Fibrosis.
PMID: 25025356 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Montuschi P, Paris D, Montella S, Melck D, Mirra V, Santini G, Mores N, Montemitro E, Majo F, Lucidi V, Bush A, Motta A, Santamaria F Tags: Am J Respir Crit Care Med Source Type: research

Neural Respiratory Drive and Ventilation in Patients with Chronic Obstructive Pulmonary Disease during Sleep.
PMID: 25025355 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Luo YM, He BT, Wu YX, Yuan H, Xu J, Moxham J, Polkey M Tags: Am J Respir Crit Care Med Source Type: research

Endobronchial tuberculosis with anthracofibrosis.
PMID: 25025354 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Paulin LM, West NE, Akulian JA, Garibaldi BT Tags: Am J Respir Crit Care Med Source Type: research

Sleep apnea and diabetes: good friends or something more?
PMID: 25025353 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Bakker JP, Patel SR Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary Hypertension due to Fibrotic Lung Disease: Hidden Value in a Neutral Trial.
PMID: 25025352 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Nathan SD, Carbone RG Tags: Am J Respir Crit Care Med Source Type: research

Wnt/β-Catenin and Transforming Growth Factor-β Signaling in Pulmonary Fibrosis. A Case for Antagonistic Pleiotropy?
PMID: 25025351 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Scheraga RG, Thannickal VJ Tags: Am J Respir Crit Care Med Source Type: research

Ivacaftor: from bench to bedside . . . And back again.
PMID: 25025350 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Molloy K, McElvaney NG Tags: Am J Respir Crit Care Med Source Type: research

A new player in the game: epithelial cathepsin s in early cystic fibrosis lung disease.
PMID: 25025349 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Mall MA, Schultz C Tags: Am J Respir Crit Care Med Source Type: research

The lipidome: a new player in chronic obstructive pulmonary disease pathophysiology?
PMID: 25025348 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Donnelly LE Tags: Am J Respir Crit Care Med Source Type: research

Inhaled Interferon: A Novel Treatment for Virus-induced Asthma?
PMID: 25025347 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Jackson DJ Tags: Am J Respir Crit Care Med Source Type: research

Plasticity of fimbrial genotype and serotype within populations of Bordetella pertussis: analysis by paired flow cytometry and genome sequencing.
Abstract The fimbriae of Bordetella pertussis are required for colonisation of the human respiratory tract. Two serologically distinct fimbrial subunits, Fim2 and Fim3, having been considered important vaccine components for many years, are included in the Sanofi Pasteur 5-component acellular pertussis vaccine, and the World Health Organisation recommends the inclusion of strains expressing both fimbrial serotypes in whole cell pertussis vaccines. Each of the fimbrial major subunit genes, fim2, fim3, and also fimX, has a promoter poly(C) tract upstream of its -10 box. Such monotonic DNA elements are susceptible to ...
Source: Microbiology - July 15, 2014 Category: Microbiology Authors: Vaughan TE, Pratt CB, Sealey K, Preston A, Fry NK, Gorringe AR Tags: Microbiology Source Type: research

Endotracheal intubation in the pediatric emergency department.
CONCLUSION: Intubation of children in the ED is a low-frequency, high-risk procedure. The incidence of adverse events, particularly desaturation and hypotension, is high. The incidence of difficult laryngoscopy is low. First pass success rate without desaturation or hypotension is low. Strategies to avoid desaturation and hypotension in the peri-intubation setting should be prioritized. PMID: 25039321 [PubMed - as supplied by publisher] (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - July 15, 2014 Category: Anesthesiology Authors: Long E, Sabato S, Babl FE Tags: Paediatr Anaesth Source Type: research

Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory Drugs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the drugs most commonly involved in hypersensitivity drug reactions. Such reactions can be due to the release of inflammatory mediators in the absence of specific immunologic recognition, or immunoglobulin E (IgE)- or T-cell–selective responses. The former include upper and lower airway symptoms in patients with chronic underlying respiratory disease, the exacerbation of chronic spontaneous urticaria, and the induction of cutaneous symptoms. The latter include selective responses to a single NSAID with good tolerance to strong cyclooxygenase-1 inhibitors, with a putative ...
Source: Immunology and Allergy Clinics of North America - July 14, 2014 Category: Allergy & Immunology Authors: Maria Jose Torres, Esther Barrionuevo, Marek Kowalski, Miguel Blanca Source Type: research

Effect of age and sex on warfarin dosing
Khoury G, Sheikh-Taha M (Source: International Journal of COPD)
Source: International Journal of COPD - July 14, 2014 Category: Respiratory Medicine Source Type: research

Barriers to the provision of smoking cessation assistance: a qualitative study among Romanian family physicians.
Conclusions:Many of the barriers described by the Romanian FPs reflected universally recognised challenges to the provision of smoking cessation advice. The context of a relatively hierarchical health-care system and limitations of time and resources exacerbated many of the problems and created new barriers that will need to be addressed if Romania is to achieve the aims of its National Programme Against Tobacco Consumption. PMID: 25010432 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - July 14, 2014 Category: Primary Care Authors: Panaitescu C, Moffat MA, Williams S, Pinnock H, Boros M, Oana CS, Alexiu S, Tsiligianni I Tags: NPJ Prim Care Respir Med Source Type: research

Severity of rhinovirus infection in hospitalized adults is unrelated to genotype.
CONCLUSIONS: Infection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders. PMID: 25015856 [PubMed - in process] (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - July 14, 2014 Category: Pathology Authors: McCulloch DJ, Sears MH, Jacob JT, Lyon GM, Burd EM, Caliendo AM, Hill CE, Nix WA, Oberste MS, Kraft CS Tags: Am J Clin Pathol Source Type: research

Respiratory disease and respiratory physiology: Putting lung function into perspective interstitial lung disease
Abstract The interstitial lung diseases pathologically involve the pulmonary interstitium but may also involve the airways, pleura and pulmonary circulation. They may be idiopathic, be part of other conditions, or be related to drug or environmental exposures. This review will focus on diagnostic and prognostic information provided by lung function tests in the idiopathic interstitial pneumonias, particularly idiopathic pulmonary fibrosis and non‐specific interstitial pneumonia. These disorders are characterized by small stiff lungs with impaired gas exchange. Lung function tests, particularly lung volumes and gas transf...
Source: Respirology - July 14, 2014 Category: Respiratory Medicine Authors: Norbert Berend Tags: Invited Review Series: Respiratory Disease: Using Lung Function Measurements to Greater Advantage Source Type: research

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
We report that biguanides inhibit complex I by inhibiting ubiquinone reduction (but not competitively) and, independently, stimulate reactive oxygen species production by the complex I flavin. Biguanides also inhibit mitochondrial ATP synthase, and two of them inhibit only ATP hydrolysis, not synthesis. Thus, we identify biguanides as a new class of complex I and ATP synthase inhibitor. By comparing biguanide effects on isolated complex I and cultured cells, we distinguish three anti-diabetic and potentially anti-neoplastic biguanides (metformin, buformin and phenformin) from two anti-malarial biguanides (cycloguanil and p...
Source: BJ Energy - July 14, 2014 Category: Biochemistry Authors: H R Bridges, A J Y Jones, M N Pollak, J Hirst Tags: BJ Energy Source Type: research

Patterns of healthcare use among adolescents attending an urban general practitioner-led urgent care centre
Conclusions Adolescents aged 15–19 years are more likely to attend urgent care centres than general practice. The majority attended for conditions commonly seen in primary care including musculoskeletal conditions and injuries, and respiratory tract infections. Primary care services may need to be more responsive to needs of the older adolescent age, if their use of urgent care centres is to be reduced. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - July 14, 2014 Category: Emergency Medicine Authors: Gnani, S., McDonald, H., Islam, S., Ramzan, F., Davison, M., Ladbrooke, T., Majeed, A., Saxena, S. Tags: TB and other respiratory infections, Adolescent health, Child health Original article Source Type: research

Cyclin D1 Mediates Estrogen Signaling
The cyclin D1 gene encodes the regulatory subunit of a holoenyzme that phosphorylates the retinoblastoma protein (pRb) and nuclear respiratory factor (NRF1) proteins. The abundance of cyclin D1 determines estrogen-dependent gene expression in the mammary gland of mice. Using estradiol (E2) and an E2–dendrimer conjugate that is excluded from the nucleus, we demonstrate that E2 delays the DNA damage response (DDR) via an extranuclear mechanism. The E2-induced DDR required extranuclear cyclin D1, which bound ERα at the cytoplasmic membrane and augmented AKT phosphorylation (Ser473) and γH2AX foci formation. In the nucleus...
Source: Cancer Research - July 14, 2014 Category: Cancer & Oncology Authors: Li, Z., Chen, K., Jiao, X., Wang, C., Willmarth, N. E., Casimiro, M. C., Li, W., Ju, X., Kim, S. H., Lisanti, M. P., Katzenellenbogen, J. A., Pestell, R. G. Tags: Tumor and Stem Cell Biology Source Type: research

Forthcoming Meetings
(Source: Respirology)
Source: Respirology - July 14, 2014 Category: Respiratory Medicine Tags: FORTHCOMING MEETINGS Source Type: research

Journal Statistics
(Source: Respirology)
Source: Respirology - July 14, 2014 Category: Respiratory Medicine Tags: JOURNAL STATISTICS Source Type: research

Carbonic Anhydrase II Mediates Malignant Behavior of Pulmonary Neuroendocrine Tumors.
Abstract In normal lung, the predominant cytoplasmic carbonic anhydrase (CA) isozyme, CAII, is highly expressed in amine and peptide producing pulmonary neuroendocrine cells (PNEC) where its role involves CO2 sensing. Here we report robust cytoplasmic expression of CAII by immunohistochemistry in the tumor cells of different native neuroendocrine tumor (NET) types including typical and atypical carcinoids and small cell lung carcinomas, and in NET and non-NET tumor cell lines. Since, in both PNEC and related NETs the hypercapnia - induced secretion of bioactive serotonin (5-HT) is mediated by CAII, we investigated ...
Source: American Journal of Respiratory Cell and Molecular Biology - July 14, 2014 Category: Molecular Biology Authors: Zhou Y, Mokhtari RB, Pan J, Cutz E, Yeger H Tags: Am J Respir Cell Mol Biol Source Type: research

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria.
Abstract Emerging evidence suggests that contact sites between different organelles form central hubs in the coordination of cellular physiology. Although recent work has emphasized the crucial role of the endoplasmic reticulum in interorganellar crosstalk, the cooperative behavior of other organelles is largely unexplored. Here, we identify a contact site named vCLAMP (vacuole and mitochondria patch) that integrates mitochondria with the lysosome-like vacuole and thus the endocytic pathway. vCLAMPs depend on the vacuolar HOPS tethering complex subunit Vps39/Vam6 and the Rab GTPase Ypt7, which also participate in m...
Source: Developmental Cell - July 14, 2014 Category: Cytology Authors: Hönscher C, Mari M, Auffarth K, Bohnert M, Griffith J, Geerts W, van der Laan M, Cabrera M, Reggiori F, Ungermann C Tags: Dev Cell Source Type: research

Performance of Masimo Rainbow Acoustic Monitoring for Tracking Changing Respiratory Rates Under Laryngeal Mask Airway General Anesthesia for Surgical Procedures in the Operating Room: A Prospective Observational Study.
CONCLUSIONS:: The data demonstrate that, under conditions of general anesthesia with a laryngeal mask airway and spontaneous ventilation, the RRa rapidly detects changes in respiratory rate, demonstrates minimal bias, and when errors in rate occur, these do not persist. The utility of this monitoring technology in detecting rate changes in unattended patients will require further study. PMID: 25025587 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - July 14, 2014 Category: Anesthesiology Authors: Atkins JH, Mandel JE Tags: Anesth Analg Source Type: research

A Universal Decision Support System: Addressing the Decision Making Needs of Patients, Families, and Clinicians in the Setting of Critical Illness.
Abstract In the setting of a complex critical illness, preference-sensitive decision making-choosing between two or more reasonable treatment options-can be difficult for patients, families, and clinicians alike. A common challenge to making high-quality decisions in this setting is a lack of critical information access and sharing among participants. Decision aids-brochures, web applications, and videos-are a major focus of current research because mounting evidence suggests they can improve decision making quality and enhance collaborative shared decision making. However, many decision aids have important limitat...
Source: American Journal of Respiratory and Critical Care Medicine - July 14, 2014 Category: Respiratory Medicine Authors: Cox CE, White DB, Abernethy AP Tags: Am J Respir Crit Care Med Source Type: research