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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Measurement of eNO with portable analyser might improve the management of persistent cough at primary care practice in Japan
ConclusionMeasurement of eNO could be one of the management tools for persistent cough at primary care practice. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - November 26, 2014 Category: Respiratory Medicine Authors: Keisuke Watanabe, Masaharu Shinkai, Masahiro Shinoda, Yu Hara, Nobuhiro Yamaguchi, Bruce K. Rubin, Yoshiaki Ishigatsubo, Takeshi Kaneko Tags: Original Article Source Type: research

Mutations in Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy
Respiratory chain deficiencies exhibit a wide variety of clinical phenotypes resulting from defective mitochondrial energy production through oxidative phosphorylation. These defects can be caused by either mutations in the mtDNA or mutations in nuclear genes coding for mitochondrial proteins. The underlying pathomechanisms can affect numerous pathways involved in mitochondrial physiology. By whole-exome and candidate gene sequencing, we identified 11 individuals from 9 families carrying compound heterozygous or homozygous mutations in GTPBP3, encoding the mitochondrial GTP-binding protein 3. (Source: The American Journal of Human Genetics)
Source: The American Journal of Human Genetics - November 26, 2014 Category: Genetics & Stem Cells Authors: Robert Kopajtich, Thomas J. Nicholls, Joanna Rorbach, Metodi D. Metodiev, Peter Freisinger, Hanna Mandel, Arnaud Vanlander, Daniele Ghezzi, Rosalba Carrozzo, Robert W. Taylor, Klaus Marquard, Kei Murayama, Thomas Wieland, Thomas Schwarzmayr, Johannes  Tags: Report Source Type: research

The Morquio A Clinical Assessment Program: Baseline results illustrating progressive, multisystemic clinical impairments in Morquio A subjects
Conclusions MPS IVA is a multisystem disorder with a continuum of clinical presentation. All affected individuals experience significant functional limitations and reduced quality of life. Older patients have more severe exercise and respiratory capacity limitations, and more frequent cardiac pathology illustrating the progressive nature of disease. Highlights ► MorCAP is the first natural history study with quantitative assessments of MPS IVA. ► Endurance, mobility, respiratory function, stature and quality of life are impacted. ► All affected individuals experience significant functional limitations. ► Increasing...
Source: Molecular Genetics and Metabolism - November 26, 2014 Category: Genetics & Stem Cells Source Type: research

A novel homozygous mutation in SUCLA2 gene identified by exome sequencing
This report demonstrates that next-generation technologies, particularly exome-sequencing, are user friendly, powerful means for the identification of disease genes in genetically and clinically heterogeneous inherited conditions, such as mitochondrial disorders. Highlights ► We report a novel homozygous mutation in the SUCLA2, identified by exome sequencing. ► Methyl-malonic aciduria can be absent in patients with SUCLA2 mutations. ► Exome sequencing is useful for the diagnosis of genetically heterogeneous diseases. (Source: Molecular Genetics and Metabolism)
Source: Molecular Genetics and Metabolism - November 26, 2014 Category: Genetics & Stem Cells Source Type: research

Severely impaired health status at diagnosis of Pompe disease: A cross-sectional analysis to explore the potential utility of neonatal screening
The objective of this study was to investigate the gains that might be achieved with earlier diagnosis by neonatal screening. For this purpose we analyzed the health and functional status of non-screened patients with Pompe disease at the time of diagnosis. Previously collected clinical data and results of an international patient-reported questionnaire were used. Cross-sectional data of 53 patients with Pompe disease diagnosed between 1999 and 2009 (aged 0–64years) were analyzed. According to the World Health Organization's International Classification of Functioning, Disability and Health the following domains are desc...
Source: Molecular Genetics and Metabolism - November 26, 2014 Category: Genetics & Stem Cells Source Type: research

Initial experience in the treatment of inherited mitochondrial disease with EPI-743
We report the first experience with EPI-743, a novel redox drug, in treating mitochondrial disease. ► EPI-743 appears to be effective in altering the natural history of mitochondrial disease. ► Mitochondrial patients showed improvement in quality-of-life. ► Brain HMPAO SPECT scan results correlated with response to EPI-743 treatment ► Prospective controlled trials will be undertaken to substantiate these initial promising observations (Source: Molecular Genetics and Metabolism)
Source: Molecular Genetics and Metabolism - November 26, 2014 Category: Genetics & Stem Cells Source Type: research

Viperin protein expression inhibits the late stage of respiratory syncytial virus morphogenesis
We examined the effect of respiratory syncytial virus (RSV) infection on viperin protein expression in the permissive HEp2 and non-permissive RAW 264.7 macrophage cell lines. In RSV-infected HEp2 cells low levels of the viperin protein was localised to the virus-induced inclusion bodies and did not impair virus transmission in these cells. In contrast, RSV-infected RAW 264.7 cells increased expression of the STAT1 protein occurred at between 6 and 12 hr post-infection, which coincided with the appearance of P-STAT1. A relatively high level of viperin protein expression was detected in infected RAW 264.7 cells, and it was e...
Source: Antiviral Therapy - November 26, 2014 Category: Virology Source Type: research

Comparative lung toxicity of engineered nanomaterials utilizing in vitro , ex vivo and in vivo approaches
Conclusion: Exposure to ENM induced acute lung inflammatory effects in a size- and chemical composition-dependent manner. The cell culture and lung slice techniques provided similar profiles of effect and help bridge the gap in our understanding of in vivo, ex vivo, and in vitro toxicity outcomes. (Source: Journal of Nanobiotechnology)
Source: Journal of Nanobiotechnology - November 26, 2014 Category: Nanotechnology Authors: Yong KimElizabeth BoykinTina StevensKatelyn LavrichMatthew Gilmour Source Type: research

Application of the steep ramp test for aerobic fitness testing in children with cancer.
CONCLUSION: The peak oxygen uptake was comparable between the SRT and the CPET, although the peak work rate was significantly higher during the SRT. This study showed that the SRT is a valid instrument to assess aerobic fitness in children with cancer. CLINICAL REHABILITATION IMPACT: The SRT is less time consuming and can be performed without gas analysis in a non--clinical setting, making it less demanding for children. PMID: 25426542 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
Source: European Journal of Physical and Rehabilitation Medicine - November 26, 2014 Category: Rehabilitation Authors: Braam KI, van Dulmen-den Broeder E, Veening MA, Merks JH, van den Heuvel Eibrink MM, Kaspers GJ, Takken T Tags: Eur J Phys Rehabil Med Source Type: research

The effect of protein supplementation on quality of life, physical function, and muscle strength in patients with chronic obstructive pulmonary disease.
CONCLUSION: This trial was unable to provide evidence for the effect of protein supplementation on quality of life, physical function, and muscle strength in non--sarcopenic patients with moderate to severe COPD. CLINICAL REHABILITATION IMPACT: The role of protein supplementation in COPD--rehabilitation should focus on identifying patients to receive supplement with protein and from those who will not benefit. PMID: 25426541 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)
Source: European Journal of Physical and Rehabilitation Medicine - November 26, 2014 Category: Rehabilitation Authors: Ahnfeldt-Mollerup P, Hey H, Johansen C, Kristensen S, Lindskov JB, Jensen C Tags: Eur J Phys Rehabil Med Source Type: research

Gardening can induce pulmonary failure: Aspergillus ARDS in an immunocompetent patient, a case report
Conclusions: In cases of sepsis that occur after gardening, clinicians should consider Aspergillus inhalation as an aetiology, and early antimycotic therapy is recommended. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - November 26, 2014 Category: Infectious Diseases Authors: Nina JungSilke MrongaSusanne SchrothTimon VassiliouFrank SommerEduard WalthersChristian AepinusAndreas JerrentrupClaus VogelmeierAngelique HollandRembert Koczulla Source Type: research

The breathtakingly simple facts of life
How much oxygen do you consume in a day? If you do the arithmetic (proportion of air extracted as oxygen, times tidal volume, times respiratory rate, times minutes per day) it comes to around 500 litres per day. We are largely unaware that we consume so much gas, probably because we cannot see or feel it, just as fish presumably cannot see or feel water. We are of course far more aware of how much food we consume, because we can detect it with every one of our senses. It totals around 600 grams per day for the average healthy person. These gaseous and solid fuels enter our bodies by different and parallel tubes, but they e...
Source: Postgraduate Medical Journal - November 26, 2014 Category: Journals (General) Authors: Launer, J. Tags: On reflection Source Type: research

The population-based Occupational and Environmental Health Prospective Cohort Study (AMIGO) in the Netherlands
Purpose Occupational and environmental exposures remain important modifiable risk factors of public health. Existing cohort studies are often limited by the level of detail of data collected on these factors and health. It is also often assumed that the more healthy group is over-represented in cohort studies, which is of concern for their external validity. In this cohort profile, we describe how we set up the population-based Occupational and Environmental Health Cohort Study (AMIGO) to longitudinally study occupational and environmental determinants of diseases and well-being from a multidisciplinary and life course poi...
Source: BMJ Open - November 26, 2014 Category: Journals (General) Authors: Slottje, P., Yzermans, C. J., Korevaar, J. C., Hooiveld, M., Vermeulen, R. C. H. Tags: Open access, Epidemiology, General practice / Family practice, Occupational and environmental medicine, Public health Research Source Type: research

Evaluating the efficacy of thoracoscopy and talc poudrage versus pleurodesis using talc slurry (TAPPS trial): protocol of an open-label randomised controlled trial
Introduction The management of recurrent malignant pleural effusions (MPE) can be challenging. Various options are available, with the most efficacious and widely used being talc pleurodesis. Talc can either be applied via a chest drain in the form of slurry, or at medical thoracoscopy using poudrage. Current evidence regarding which method is most effective is conflicting and often methodologically flawed. The TAPPS trial is a suitably powered, multicentre, open-label, randomised controlled trial designed to compare the pleurodesis success rate of medical thoracoscopy and talc poudrage with chest drain insertion and talc ...
Source: BMJ Open - November 26, 2014 Category: Journals (General) Authors: Bhatnagar, R., Laskawiec-Szkonter, M., Piotrowska, H. E. G., Kahan, B. C., Hooper, C. E., Davies, H. E., Harvey, J. E., Miller, R. F., Rahman, N. M., Maskell, N. A. Tags: Open access, Oncology, Respiratory medicine Protocol Source Type: research

Respiratory‐related Outputs of Glutamatergic, Hypercapnia‐Responsive Parabrachial Neurons in Mice
This article is protected by copyright. All rights reserved. Using c‐Fos immunohistochemistry combined with retrograde tracing and in situ hybridization the authors showed that hypercapnia‐activated glutamatergic neurons in parabrachial complex were labeled after retrograde tracer injection into respiratory motor nuclei, making them candidates for mediating respiratory‐facilitatory and upper airway stabilizing effects of hypercapnia. (Source: The Journal of Comparative Neurology)
Source: The Journal of Comparative Neurology - November 26, 2014 Category: Neurology Authors: Shigefumi Yokota, Satvinder Kaur, Veronique G. VanderHorst, Clifford B. Saper, Nancy L. Chamberlin Tags: Research Article Source Type: research

Tuberculin skin test and QuantiFERON‐TB Gold In‐tube Test for latent tuberculosis in Thai HIV‐infected adults
ConclusionsIn our setting where QFT‐IT is available but has limited use due to cost, TST with a cut‐off of 10 mm for reactivity should be the initial LTB test. HIV‐infected women and persons older than 52 years with non‐reactive TST and long‐term smokers with reactive TST may benefit from subsequent QFT‐IT. (Source: Respirology)
Source: Respirology - November 26, 2014 Category: Respiratory Medicine Authors: Thana Khawcharoenporn, Anucha Apisarnthanarak, Benjawan Phetsuksiri, Janisara Rudeeaneksin, Sopa Srisungngam, Linda M. Mundy Tags: Original Article Source Type: research

Association of polymorphisms in drug transporter genes ( and ) and anti-tuberculosis drug-induced hepatotoxicity in a Chinese cohort
This study investigated the association between genetic variants in two hepatic uptake transporter genes (SLCO1B1 and SLC10A1) and the risk of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in a Chinese cohort. The frequencies and distributions of single nucleotide polymorphisms (SNPs) and haplotypes of these genes were compared among 89 incident ATDH cases and 356 matched ATDH-free controls using a multivariate conditional logistic regression analysis. After correction for potential confounding factors, significant differences were found in polymorphism of rs4149014 under an addictive model (P=0.008) and a recessive...
Source: Tuberculosis - November 26, 2014 Category: Respiratory Medicine Authors: Ru Chen, Jing Wang, Shaowen Tang, Yuan Zhang, Xiaozhen Lv, Shanshan Wu, Yinyin Xia, Peiyuan Deng, Yu Ma, Dehua Tu, Dafang Chen, Siyan Zhan Tags: Host Genetics of Susceptibility Source Type: research

Timing of repair of congenital diaphragmatic hernia in patients supported by extracorporeal membrane oxygenation (ECMO)
The optimal timing of repair for congenital diaphragmatic hernia (CDH) in patients requiring extracorporeal membrane oxygenation (ECMO) is controversial. Repair during ECMO may improve respiratory function by restoring normal anatomy. However, there is increased risk of complications including surgical bleeding. The purpose of this study was to examine the impact of timing of CDH repair on outcomes in a large cohort of patients treated at a single institution. (Source: Journal of Pediatric Surgery)
Source: Journal of Pediatric Surgery - November 26, 2014 Category: Surgery Authors: Emily A. Partridge, William H. Peranteau, Natalie E. Rintoul, Lisa M. Herkert, Alan W. Flake, N. Scott Adzick, Holly L. Hedrick Source Type: research

Management of Hazardous Material Emergencies
As this issue of Emergency Medicine Clinics of North America goes to press, the United States is extraordinarily preoccupied with a number of health concerns indirectly related to the topic of this tome, hazardous materials preparedness. The nation has recently suffered its first death due to Ebola and observed the first case of transmission of the disease in this country. Pediatric intensive care units throughout the country are struggling with respiratory illness caused by Enterovirus D 68. Unrest in the Middle East has raised the specter of a domestic terrorist attack by sympathizers of the so-called Islamic State. (Sou...
Source: Emergency Medicine Clinics of North America - November 25, 2014 Category: Emergency Medicine Authors: Stephen W. Borron, Ziad Kazzi Tags: Preface Source Type: research

Propolis: a wonder bees product and its pharmacological potentials.
Authors: Wagh VD Abstract Propolis is a natural resinous mixture produced by honey bees from substances collected from parts of plants, buds, and exudates. Due to its waxy nature and mechanical properties, bees use propolis in the construction and repair of their hives for sealing openings and cracks and smoothing out the internal walls and as a protective barrier against external invaders like snakes, lizards, and so forth, or against weathering threats like wind and rain. Bees gather propolis from different plants, in the temperate climate zone mainly from poplar. Current antimicrobial applications of propolis in...
Source: Advances in Pharmacological Sciences - November 25, 2014 Category: Drugs & Pharmacology Tags: Adv Pharmacol Sci Source Type: research

A comparative study of dexmedetomidine and propofol as sole sedative agents for patients with aneurysmal subarachnoid hemorrhage undergoing diagnostic cerebral angiography
Conclusion Dexmedetomidine appears to be superior to propofol as a sole sedative agent for sedation during cerebral angiography in patients with subarachnoid hemorrhage. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - November 25, 2014 Category: Anesthesiology Source Type: research

Asthma
Respiratory viruses and allergens synergistically contribute to disease pathogenesis in asthma. Potential mechanisms underlying this clinically relevant association are the subject of intense investigation. This review summarizes current knowledge and recent advances in this area, with an emphasis on potential mechanisms involving immunoglobulin E, type I interferon antiviral responses, epithelial factors, and the role of dendritic cells and other antigen-presenting cells in linking viral and allergic inflammatory responses relevant to asthmatic disease. (Source: Immunology and Allergy Clinics of North America)
Source: Immunology and Allergy Clinics of North America - November 25, 2014 Category: Allergy & Immunology Authors: Regina K. Rowe, Michelle A. Gill Source Type: research

Respiratory Sinus Arrhythmia: a Marker of Resilience to Pain Induction
Conclusions Respiratory sinus arrhythmia appears to be a promising indicator of physiological resilience to pain, predicting an attenuated effect of repeated pain exposure on self-reported fatigue. Implications of efficient regulation of pain, fatigue, and long-term physical health are discussed. (Source: International Journal of Behavioral Medicine)
Source: International Journal of Behavioral Medicine - November 25, 2014 Category: Psychiatry Source Type: research

Atypical patterns of respiratory sinus arrhythmia index an endophenotype for depression
Research Articles Ilya Yaroslavsky, Jonathan Rottenberg, Maria Kovacs, Development and Psychopathology, Volume 26 Special Issue 4pt2, pp 1337-1352Abstract (Source: Development and Psychopathology)
Source: Development and Psychopathology - November 25, 2014 Category: Child Development Source Type: research

Equine Viral Arteritis
Equine arteritis virus (EAV), the causative agent of equine viral arteritis (EVA), is a respiratory and reproductive disease that occurs throughout the world. EAV infection is highly species-specific and exclusively limited to members of the family Equidae, which includes horses, donkeys, mules, and zebras. EVA is an economically important disease and outbreaks could cause significant losses to the equine industry. The primary objective of this article is to summarize current understanding of EVA, specifically the disease, pathogenesis, epidemiology, host immune response, vaccination and treatment strategies, prevention an...
Source: Veterinary Clinics of North America: Equine Practice - November 25, 2014 Category: Veterinary Research Authors: Udeni B.R. Balasuriya Source Type: research

Forthcoming Issues
Updates on Respiratory Medicine and Surgery (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - November 25, 2014 Category: Veterinary Research Source Type: research

Effectiveness of a modified open airways curriculum
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - November 25, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Sensitivity of different spirometric tests for detecting airway obstruction in childhood asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - November 25, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Self‐gated cardiac Cine MRI of the rat on a clinical 3T MRI system
The ability to perform small animal functional cardiac imaging on clinical MRI scanners may be of particular value in cases in which the availability of a dedicated high field animal MRI scanner is limited. Here, we propose radial MR cardiac imaging in the rat on a whole‐body clinical 3 T scanner in combination with interspersed projection navigators for self‐gating without any additional external triggering requirements for electrocardiogram (ECG) and respiration. Single navigator readouts were interspersed using the same TR and a high navigator frequency of 54 Hz into a radial golden‐angle acquisition. The extr...
Source: NMR in Biomedicine - November 25, 2014 Category: Radiology Authors: Martin Krämer, Karl‐Heinz Herrmann, Judith Biermann, Sebastian Freiburger, Michael Schwarzer, Jürgen R. Reichenbach Tags: Research article Source Type: research

Identification and Quantitation of Superoxide Anion: Essential Steps in Elucidation of the Phagocyte "Respiratory Burst"
PMID: 25411429 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 25, 2014 Category: Allergy & Immunology Authors: Nauseef WM Tags: J Immunol Source Type: research

Vaccines against Respiratory Viral Pathogens for Use in Neonates: Opportunities and Challenges.
Abstract The first six months of life reflect a time of high susceptibility to severe disease following respiratory virus infection. Although this could be improved significantly by immunization, current vaccines are not approved for use in these very young individuals. This is the result of the combined effects of poor immune responsiveness and safety concerns regarding the use of live attenuated vaccines or potent adjuvants in this population. Vaccines to effectively combat respiratory viral infection ideally would result in robust CD4(+) and CD8(+) T cell responses, as well as high-affinity Ab. Inclusion of TLR ...
Source: Journal of Immunology - November 25, 2014 Category: Allergy & Immunology Authors: Alexander-Miller MA Tags: J Immunol Source Type: research

Cost-effectiveness of omalizumab in severe persistent asthma in Spain: a real-life perspective
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - November 25, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Value of serum and bronchoalveolar fluid lavage pro- and anti-inflammatory cytokine levels for predicting bronchopulmonary dysplasia in premature infants.
CONCLUSION: It is suggested that higher serum and TA pro-inflammatory cytokine (TNF-α, IL-1β, IL-6) concentrations, along with lower anti-inflammatory cytokine (IL-10) concentrations, might be used for predicting the development of BPD in premature infants with respiratory distress at birth. PMID: 22591771 [PubMed - indexed for MEDLINE] (Source: European Cytokine Network)
Source: European Cytokine Network - November 25, 2014 Category: Neuroscience Tags: Eur Cytokine Netw Source Type: research

Statistical, spectral and non-linear analysis of the heart rate variability during wakefulness and sleep.
In conclusion, HRV parameters, including complexity, are deeply modified across behavioral states. PMID: 25181595 [PubMed - in process] (Source: Archives Italiennes de Biologie)
Source: Archives Italiennes de Biologie - November 25, 2014 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD).
Authors: Zago S, Poletti B, Morelli C, Doretti A, Silani V Abstract There is increasing clinical, imaging and neurophatological evidence that amyotrophic lateral sclerosis (ALS) represents a multisystem neurodegenerative disease. Neurodegeneration is not restricted to motor neurons, but also includes parts of the brain other than the motor cortex, especially the prefrontal and/or anterior temporal lobe, that contribute to the clinical syndrome. In some cases an evident dementia that resembles frontotemporal degeneration (FTD) was observed. It is now suggested that ALS and FTD are closely related conditions with ove...
Source: Archives Italiennes de Biologie - November 25, 2014 Category: Neuroscience Tags: Arch Ital Biol Source Type: research

Unaffected motor endplate occupancy in eye muscles of ALS G93A mouse model.
Authors: Tjust AE, Brannstrom T, Pedrosa Domellof F Abstract Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disorder characterised by selective loss of motor neurons with accompanying muscle paralysis and respiratory failure. Despite progressive paralysis in trunk and extremity muscles, disturbed eye motility is not a hallmark of ALS. Extraocular muscles (EOMs) of terminal ALS patients show far less morphological signs of disease than their limb muscles. One of the earliest signs of the disease in the transgenic G93A SOD1 mouse model of ALS is loss of motor neuron contact at the neur...
Source: Frontiers in Bioscience - Scholar - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Schol Ed) Source Type: research

Asthma and viruses: is there a relationship?
Authors: Moser S, Peroni DG, Comberiati P, Piacentini GL Abstract Asthma is a multifactorial disease in which many factors play a role in its development and exacerbations. Viral infections are known to be the main cause of asthmatic exacerbations and are often the first manifestation of asthma in preschool age. However, there is much evidence suggesting a role of viral infections even in asthma development. Respiratory Syncytial Virus (RSV). has been first associated with an increased risk to develop asthma, but recently new viruses have been proposed to be involved in asthma pathogenesis. Further studies will be ...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

Is vitamin D deficiency correlated with childhood wheezing and asthma?
Authors: Comberiati P, Tsabouri S, Piacentini GL, Moser S, Minniti F, Peroni DG Abstract There is increasing evidence that vitamin D regulates immune responses. There is also epidemiological evidence of a relationship between vitamin D deficiency and development of asthma. In addition, several epidemiological studies suggest that low levels of vitamin D during pregnancy and early life are inversely associated with the risk of developing respiratory infections and wheezing in childhood. Vitamin D also seems to reduce asthma exacerbation and increase the response to glucocorticoids. These findings have led to conside...
Source: Frontiers in Bioscience - Elite - November 25, 2014 Category: Biomedical Science Tags: Front Biosci (Elite Ed) Source Type: research

A multicentre, randomised, double-blind, placebo-controlled trial of aminophylline for bronchiolitis in infants admitted to intensive care.
CONCLUSION: Not enough children were recruited for the study to test the hypothesis that aminophylline reduces the need for respiratory support in severe bronchiolitis. Consequently, the role of aminophylline in the management of severe bronchiolitis remains unknown. PMID: 25161026 [PubMed - indexed for MEDLINE] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A multicentre feasibility study evaluating stress ulcer prophylaxis using hospital-based registry data.
CONCLUSIONS: It is feasible to use existing data sources to measure process-of-care and outcome data necessary for a registry-based interventional trial of SUP. PMID: 25161016 [PubMed - indexed for MEDLINE] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Prolonged venovenous extracorporeal membrane oxygenation without anticoagulation: a case of Goodpasture syndrome-related pulmonary haemorrhage.
We present a 16-year-old male with severe acute respiratory and renal failure as a result of Goodpasture syndrome, requiring venovenous extracorporeal membrane oxygenation (VV-ECMO) for pulmonary haemorrhage. The patient received no systemic anticoagulation for 25 of 26 ECMO days (20 days consecutively) and suffered no coagulation-related adverse events. The patient had a subtherapeutic anticoagulation profile according to recommended ECMO guidelines during most of this time. The patient made a full recovery without respiratory compromise, ECMO circuit failure, thrombotic events or the need for ongoing haemodialysis. ...
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Effects of non-invasive ventilation on reintubation rate: a systematic review and meta-analysis of randomised studies of patients undergoing cardiothoracic surgery.
CONCLUSIONS: NIV seems to be effective in reducing reintubation rate after cardiothoracic surgery. The results of this meta-analysis should be confirmed by large randomised controlled studies. PMID: 23944209 [PubMed - indexed for MEDLINE] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

A meta-analysis of complications and mortality of extracorporeal membrane oxygenation.
CONCLUSIONS: Even with conditions usually associated with a high chance of death, almost 50% of patients receiving ECMO survive up to discharge. Complications are frequent and most often comprise renal failure, pneumonia or sepsis, and bleeding. PMID: 23944202 [PubMed - indexed for MEDLINE] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Fluid balance does not predict estimated sodium balance in critically ill mechanically ventilated patients.
CONCLUSIONS: Fluid balance may not reflect sodium balance in critically ill patients. As sodium balance correlates with respiratory dysfunction and increased extracellular volume, further studies examining sodium balance and morbidity seem warranted. PMID: 23931039 [PubMed - indexed for MEDLINE] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - November 25, 2014 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using yeast models of OXPHOS deficiencies.
Authors: Fontanesi F, Diaz F, Barrientos A Abstract The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondrial and nuclear DNA mutations affecting the accumulation and function of these enzymes are the most common cause of mitochondrial diseases and have also been associated with neurodegeneration and aging. Several approaches for the assessment of the OXPHOS system enzymes have been developed. Based on the methods described elsewhere, this unit describes the creation and ...
Source: Current Protocols in Human Genetics - November 25, 2014 Category: Genetics & Stem Cells Tags: Curr Protoc Hum Genet Source Type: research

Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using blue native gel electrophoresis.
Authors: Díaz F, Barrientos A, Fontanesi F Abstract The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondrial and nuclear DNA mutations affecting the accumulation and function of these enzymes are the most common cause of mitochondrial diseases and have also been associated with neurodegeneration and aging. For this reason, several approaches for the assessment of the OXPHOS system enzymes have been progressively developed. Based on methods described elsewhere, the use o...
Source: Current Protocols in Human Genetics - November 25, 2014 Category: Genetics & Stem Cells Tags: Curr Protoc Hum Genet Source Type: research

Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays.
Authors: Barrientos A, Fontanesi F, Díaz F Abstract The oxidative phosphorylation (OXPHOS) system consists of five multimeric complexes embedded in the mitochondrial inner membrane. They work in concert to drive the aerobic synthesis of ATP. Mitochondrial and nuclear DNA mutations affecting the accumulation and function of these enzymes are the most common cause of mitochondrial diseases and have also been associated with neurodegeneration and aging. For this reason, several approaches for the assessment of the OXPHOS system enzymes have been developed. Based on the methods described elsewhere, the assays describe...
Source: Current Protocols in Human Genetics - November 25, 2014 Category: Genetics & Stem Cells Tags: Curr Protoc Hum Genet Source Type: research

Pattern of primary care clinic visits of adult asthmatics.
CONCLUSIONS: A different pattern of consultations was observed. Asthmatics visited their doctors more frequently than patients without asthma, mainly consulting for various respiratory problems. PMID: 11081357 [PubMed - indexed for MEDLINE] (Source: Public Health Reviews)
Source: Public Health Reviews - November 25, 2014 Category: Global & Universal Tags: Public Health Rev Source Type: research