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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Can biliary endoscopy play a role in liver disease associated to cystic fibrosis?
Biliopathy associated to cystic fibrosis (CF) is a relatively rare condition in adult patients. Recently, an increase in life expectancy for patients with cystic fibrosis (CF) has been reported. Therefore, a new clinical picture related to CF- associated liver involvement is quite often observed [1]. The involvement of the biliary tree has been hypothesized as having a pivotal role in the pathogenesis and evolution of liver cirrhosis, but there is a lack of systematic data about it [1,2]. The impact of endotherapy on the biliopathy and liver disease in adult cystic fibrosis patients needs sistematic evaluation with a long-...
Source: Journal of Cystic Fibrosis - July 24, 2015 Category: Respiratory Medicine Authors: P. Cantù, L. Claut, A. Elvevi, I. Parzanese, M. Maggioni, D. Conte, R. Penagini, C. Colombo Tags: Letter to the Editor Source Type: research

Effects of positive end-expiratory pressure on brain tissue oxygen pressure of severe traumatic brain injury patients with acute respiratory distress syndrome: a pilot study
: To verify whether high positive end-expiratory pressure levels can increase brain tissue oxygen pressure, and also their effects on pulse oxygen saturation, intracranial pressure and cerebral perfusion pressure. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 24, 2015 Category: Intensive Care Authors: Sérgio Nogueira Nemer, Jefferson B. Caldeira, Ricardo G. Santos, Bruno L. Guimarães, João Márcio Garcia, Darwin Prado, Ricardo T. Silva, Leandro M. Azeredo, Eduardo R. Faria, Paulo Cesar P. Souza Source Type: research

Decaffeinated green tea extract rich in epigallocatechin-3-gallate prevents fatty liver disease by increased activities of mitochondrial respiratory chain complexes in diet-induced obesity mice
Non-alcoholic fatty liver disease has been considered the hepatic manifestation of obesity. It is unclear whether supplementation with green tea extract rich in epigallocathechin-3-gallate (EGCG) influences the activity of mitochondrial respiratory chain complexes and insulin resistance in the liver. EGCG regulated hepatic mitochondrial respiratory chain complexes and was capable of improving lipid metabolism, attenuating insulin resistance in obese mice. The mice were divided into four groups: control diet+water (CW) or EGCG (CE); hyperlipidic diet+water (HFW) or EGCG (HFE). (Source: The Journal of Nutritional Biochemistry)
Source: The Journal of Nutritional Biochemistry - July 24, 2015 Category: Biochemistry Authors: A.B. Santamarina, M. Carvalho-Silva, L.M. Gomes, M.H. Okuda, A.A. Santana, E.L. Streck, M. Seelaender, C.M. Oller do Nascimento, E.B. Ribeiro, F.S. Lira, L.M. Oyama Source Type: research

Urine Nested Polymerase Chain Reaction in Neonatal Septicemia
This cross-sectional study was done to evaluate diagnostic efficacy of urine nested polymerase chain reaction (PCR) using broad-range 16SrDNA PCR-based amplification, followed by restriction analysis and sequencing in neonatal septicemia. The study included 50 babies; 48% had vaginal delivery, 46% were preterm, 20% had a history of prolonged rupture of membranes and 56% were low birth weight (≤2500 g). Clinical presentations were lethargy (96%), respiratory distress (80%) and bleeding diathesis (16%). Absolute neutrophil count <1800/mm3 was observed in 60%, and positive C-reactive protein in 46%. Thirty neonates had ...
Source: Journal of Tropical Pediatrics - July 24, 2015 Category: Tropical Medicine Authors: Das, B. K., Suri, S., Nath, G., Prasad, R. Tags: Original Papers Source Type: research

Protocadherin-1 binds to SMAD3 and suppresses TGFβ1-induced gene transcription.
In conclusion, we demonstrate that PCDH1 binds to SMAD3 and regulates its activation by TGF-β signaling in bronchial epithelial cells. We propose that PCDH1 and SMAD3 act in a single pathway in asthma susceptibility that affects the sensitivity of the airway epithelium to TGF-β. PMID: 26209277 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Faura Tellez G, Vandepoele K, Brouwer U, Koning H, Elderman RM, Hackett TL, Willemse BW, Holloway J, Van Roy F, Koppelman GH, Nawijn MC Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Regulation of Allergic Lung Inflammation by Endothelial Cell Transglutaminase 2.
Abstract Tissue transglutaminase 2 (TG2) is an enzyme with multiple functions, including catalysis of serotonin conjugation to proteins (serotonylation). Previous research indicates that TG2 expression is upregulated in human asthma and in the lung endothelium of OVA-challenged mice. It is not known whether endothelial TG2 is required for allergic inflammation. Therefore, to determine whether endothelial cell TG2 regulates allergic inflammation, mice with an endothelial cell-specific deletion of TG2 were generated, and then these mice were sensitized and challenged in the airways with OVA. Deletion of TG2 in endoth...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Soveg F, Abdala-Valencia H, Campbell J, Morales-Nebreda L, Mutlu GM, Cook-Mills JM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Murine and human CFTR exhibit different sensitivities to CFTR potentiators.
Abstract Development of therapeutic molecules with clinical efficacy as modulators of defective CFTR includes efforts to identify potentiators which can overcome or repair the gating defect in mutant CFTR channels. This has taken a great leap forward with the identification of the potentiator VX-770, now available to patients as "Kalydeco". Other small molecules with different chemical structure also are capable of potentiating the activity of either wildtype or mutant CFTR, suggesting that there are features of the protein that may be targeted in order to achieve stimulation of channel activity by structurally div...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Cui G, McCarty NA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

NAD(P)H oxidase subunit p47phox is elevated and p47phox knockout prevents diaphragm contractile dysfunction in heart failure.
Abstract Patients with chronic heart failure (CHF) have dyspnea and exercise intolerance that are caused, in part, by diaphragm abnormalities. Oxidants impair diaphragm contractile function, and CHF increases diaphragm oxidants. However, the specific source of oxidants and its relevance to diaphragm abnormalities in CHF is unclear. The p47(phox)-dependent Nox2 isoform of NAD(P)H oxidase is a putative source of diaphragm oxidants. Thus, we conducted our study with the goal of determining the effects of CHF on diaphragm abundance of Nox2 complex subunits and test the hypothesis that p47(phox) knockout prevents diaphr...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Ahn BS, Beharry AW, Frye GS, Judge AR, Ferreira LF Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Cigarette smoke induced disruption of pulmonary barrier and bacterial translocation drive tumor associated inflammation and growth.
Abstract Microorganisms have an important role in tumorgenesis by the induction of inflammation and by a direct impact on tumor cells. Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for lung cancer and microbial colonization. We asked whether bacterial pathogens act as tumor promoters during CS-induced pulmonary inflammation. In a metastatic lung cancer (LC) model, Lewis lung carcinoma (LLC) cells were injected in mice to initiate the growth of tumors in the lung. Exposure to the combination of cigarette smoke (CS) and non-typeable Haemophilus influenzae (NTHi) synergistically inc...
Source: Am J Physiol Lung Ce... - July 24, 2015 Category: Respiratory Medicine Authors: Jungnickel C, Wonnenberg B, Karabiber O, Wolf A, Voss M, Wolf L, Honecker A, Kamyschnikow A, Herr C, Bals R, Beisswenger C Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Precision Medicine: At What Price.
Abstract Not applicable. PMID: 26207804 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 24, 2015 Category: Respiratory Medicine Authors: Ferkol T, Quinton P Tags: Am J Respir Crit Care Med Source Type: research

Regulation of 26S Proteasome Activity in Pulmonary Fibrosis.
CONCLUSION: Our study identifies Rpn6-dependent 26S proteasome activation as an essential feature of myofibroblast differentiation in vitro and in vivo and suggests an important role in IPF pathogenesis. PMID: 26207697 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 24, 2015 Category: Respiratory Medicine Authors: Semren N, Welk V, Korfei M, Keller IE, Fernandez IE, Adler H, Günther A, Eickelberg O, Meiners S Tags: Am J Respir Crit Care Med Source Type: research

Blindness and Deafness as Initial Manifestation of Non-small Cell Lung Cancer.
PMID: 26216716 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Nascimento LM, Reis R, Fernandes A Tags: Arch Bronconeumol Source Type: research

Long-term Outcome of Patients With Undiagnosed Pleural Effusion.
CONCLUSION: Although the probability is low, some patients with exudative pleural effusion undiagnosed after pleural biopsy via video-assisted thoracoscopic surgery may have malignant disease. Patients with an initially large volume of effusion that re-accumulates after examination should be closely monitored. PMID: 26216715 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Gunluoglu G, Olcmen A, Gunluoglu MZ, Dincer I, Sayar A, Camsari G, Yilmaz V, Altin S Tags: Arch Bronconeumol Source Type: research

Inhaled corticosteroids in chronic obstructive pulmonary disease: Some considerations.
PMID: 26216714 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 24, 2015 Category: Respiratory Medicine Authors: Baloira Villar A, Núñez Fernández M, Pallarés Sanmartín A Tags: Arch Bronconeumol Source Type: research

Digital gene expression analysis of transcriptomes in lipopolysaccharide-induced acute respiratory distress syndrome.
CONCLUSIONS: Using the powerful technology of DGE, we present, to our knowledge, the first in-depth transcriptomic analysis of mouse lungs after LPS exposure. We found some differentially expressed genes that might play important roles in the pathogenesis of ARDS. PMID: 26216187 [PubMed - as supplied by publisher] (Source: International Journal of Clinical Chemistry)
Source: International Journal of Clinical Chemistry - July 24, 2015 Category: Chemistry Authors: Lv XJ, Zhang YJ, Lu WZ, Wang Q, Li SY, Guo L, Qian GS, Zhou SW, Li YY Tags: Clin Chim Acta Source Type: research

Development of port‐site metastases following thoracoscopic resection of a neuroblastoma
We report a 26‐month‐old female who developed port‐site metastases of a neuroblastoma following minimally invasive thoracoscopic interventions. After diagnosis of an intrathoracic low‐risk neuroblastoma and 6 months of observation, she developed respiratory problems. She subsequently underwent total resection of a locally progressive tumor via thoracoscopy. Six months later, she developed local relapse and subcutaneous metastases within the thoracic wall. These port‐site metastases were most likely iatrogenic. After excision of metastases, the residual tumor responded well to salvage chemotherapy. The patient has...
Source: Pediatric Blood and Cancer - July 23, 2015 Category: Cancer & Oncology Authors: Falk Pentek, Johannes H. Schulte, Bernd Schweiger, Martin Metzelder, Michael M. Schündeln Tags: Brief Report Source Type: research

Sequence variants on 17q21 are associated with the susceptibility of asthma in the population of Lahore, Pakistan
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - July 23, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Endotracheal Tube Management and Obstructed Airway
Thoracic surgery encompasses a wide array of surgical techniques, most of which require lung isolation for surgical exposure in the pleural cavity; this, in turn, demands an extensive knowledge of respiratory mechanics and modalities of airway control. Likewise, effective treatment of an acute central airway obstruction calls for a systematic approach using clear communication between teams and a comprehensive knowledge of available therapeutic modalities by the surgeon. (Source: Thoracic Surgery Clinics)
Source: Thoracic Surgery Clinics - July 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Manu Sancheti, Seth Force Source Type: research

Dexmedetomidine for tracheal extubation in deeply anesthetized adult patients after otologic surgery: a comparison with remifentanil
Background: Remifentanil and dexmedetomidine are well known to suppress airway reflexes during airway procedures. Smooth tracheal extubation is important after otologic surgery. The purpose of this study is to compare the effectiveness of dexmedetomidine or remifentanil infusion for producing smooth tracheal extubation in deeply anesthetized patients after otologic surgery. Methods: Seventy-four ASA I-II adult patients (18-60 years old) scheduled for elective otologic surgery were randomly assigned to one of three groups: sevoflurane-remifentanil (Group SR, n = 25), sevoflurane-dexmedetomidine (0.5 μg/kg) (Group SD5,...
Source: BMC Anesthesiology - July 23, 2015 Category: Anesthesiology Authors: Qing FanChunbo HuMin YeXia Shen Source Type: research

Humidification devices
Publication date: Available online 21 July 2015 Source:Anaesthesia &amp; Intensive Care Medicine Author(s): David R. Ball Humidification is a process of adding water vapour to a volume of one or more gases. Natural humidification is achieved in the nasal cavity, but this process is often bypassed during anaesthesia and critical care. Various devices are used for artificial humidification, the most common is heat and moisture exchanger combined with a microbial filter. Electrically heated water baths may be used; new devices are combined with high-flow oxygen delivery to provide non-invasive respiratory support. (Sou...
Source: Anaesthesia and intensive care medicine - July 23, 2015 Category: Anesthesiology Source Type: research

Rapid Repression of ADP Transport by Palmitoyl-CoA Is Attenuated by Exercise Training in Humans: A Potential Mechanism to Decrease Oxidative Stress and Improve Skeletal Muscle Insulin Signaling
Mitochondrial ADP transport may represent a convergence point unifying two prominent working models for the development of insulin resistance, as reactive lipids (specifically palmitoyl-CoA [P-CoA]) can inhibit ADP transport and subsequently increase mitochondrial reactive oxygen species emissions. In the current study, we aimed to determine if exercise training in humans diminished P-CoA attenuation of mitochondrial ADP respiratory sensitivity. Six weeks of exercise training increased whole-body glucose homeostasis and skeletal muscle Akt signaling and reduced markers of oxidative stress without reducing maximal mitochond...
Source: Diabetes - July 23, 2015 Category: Endocrinology Authors: Ludzki, A.; Paglialunga, S.; Smith, B. K.; Herbst, E. A. F.; Allison, M. K.; Heigenhauser, G. J.; Neufer, P. D.; Holloway, G. P. Tags: Metabolism Source Type: research

Human Bocavirus 1 Primary Infection and Shedding in Infants
Conclusions HBoV-1 primary shedding events are associated with mild respiratory illness with subsequent prolonged detection of HBoV-1 DNA for up to a year. HBoV-1 reinfection contributes to long-term shedding. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - July 23, 2015 Category: Infectious Diseases Authors: Martin, E. T., Kuypers, J., McRoberts, J. P., Englund, J. A., Zerr, D. M. Tags: VIRUSES Source Type: research

A case of bronchiolitis obliterans organizing pneumonia in an HIV-infected Korean patient successfully treated with clarithromycin
Conclusion: This case suggests that macrolides are a potential treatment option in HIV-infected patients with mild BOOP. In cases that are otherwise unexplained or unresponsive to treatment, BOOP should be taken into consideration and surgical biopsy performed to confirm a diagnosis of BOOP. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 23, 2015 Category: Infectious Diseases Authors: In JungYong JeonMi-young AhnEunkyong GoagEunHye LeeHea AhnJin AhnNam KuJune KimJun Choi Source Type: research

Management of pain following craniotomy.
Abstract Pain following craniotomy is common, however, achieving effective analgesia can be difficult. The assessment of pain postoperatively can be a challenge in patients who are obtunded (not fully alert) and the severity of pain has historically been underestimated. There are also concerns about side-effects from drugs, particularly with opioids, which may lead to reluctance to administer effective doses. Paracetamol is generally safe and, if given intravenously, provides rapid analgesia, although there are risks associated with overdose and care must be taken to ensure that the safe daily limit is not exceeded...
Source: British Journal of Nursing - July 23, 2015 Category: Nursing Authors: Puntis M, Garner A Tags: Br J Nurs Source Type: research

Infants born before 32 weeks of gestation or with respiratory disease are most likely to receive palivizumab in the Netherlands
ConclusionOnly 15% of eligible infants in the Netherlands received palivizumab and they were mostly born before 32 weeks, in line with Dutch guidelines. (Source: Acta Paediatrica)
Source: Acta Paediatrica - July 23, 2015 Category: Pediatrics Authors: Leanne M.A. Kool‐Houweling, Fernie J.A. Penning‐van Beest, Irene D. Bezemer, Richard A. van Lingen, Ron M.C. Herings Tags: Regular Article Source Type: research

Early markers of right heart involvement in regular smokers by Pocket Size Imaging Device
PurposeTo test the diagnostic power of Pocket Size Imaging Device (PSID) in detecting early signs of right heart (RH) involvement in regular smokers (RS) free of overt cardiac involvement. Methods: One-hundred-forty-three regular smokers and 51 healthy controls, comparable for age and sex, underwent physical exam (PE), PSID exam and standard echocardiography. Based on a simplified Boston score, ≥1 of clinical signs (jugular venous distension, hepatomegaly, peripheral pitting oedema and abnormal pulmonary sounds) were considered indicative of RH involvement. A composite score (1 to 4) obtained by summing the points of fou...
Source: Cardiovascular Ultrasound - July 23, 2015 Category: Radiology Authors: Vincenzo Schiano-LomorielloRoberta EspositoCiro SantoroGiovanni de SimoneMaurizio Galderisi Source Type: research

Exhaled breath temperature measurement: Applicability in childhood
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 23, 2015 Category: Respiratory Medicine Authors: Todor A. Popov, Tanya Z. Kralimarkova Tags: Letter to the Editor Source Type: research

An infant with a hyperlucent chest mass: An unexpected diagnosis
We report an unusual finding of pneumatocele in an infant. Case ReportA previously well four month old presented with worsening respiratory distress over 6 weeks. He had no antecedent signs or symptoms of respiratory infection. Chest radiograph demonstrated a lucent hemithorax concerning for tension pneumothorax. Urgent needle decompression was performed. Chest CT showed a persistent dominant macrocyst on the left. Thoracotomy revealed a large cystic lesion necessitating a left lower lobectomy. Histopathology was consistent with a pneumatocele. He remains clinically stable at 16 months postoperatively. DiscussionPneumatoce...
Source: Pediatric Pulmonology - July 23, 2015 Category: Respiratory Medicine Authors: Zarmina Ehsan, Jaimie D. Nathan, Carolyn M. Kercsmar Tags: Case Report Source Type: research

Minimizing the evidence-practice gap – a prospective cohort study incorporating balance training into pulmonary rehabilitation for individuals with chronic obstructive pulmonary disease
Background: We have recently demonstrated the efficacy of balance training in addition to Pulmonary Rehabilitation (PR) at improving measures of balance associated with an increased risk of falls in individuals with Chronic Obstructive Pulmonary Disease (COPD). Few knowledge translation (KT) projects have been conducted in rehabilitation settings. The goal of this study was to translate lessons learnt from efficacy studies of balance training into a sustainable clinical service. Methods: Health care professionals (HCPs) responsible for delivering PR were given an hour of instruction on the principles and practical applicat...
Source: BMC Pulmonary Medicine - July 23, 2015 Category: Respiratory Medicine Authors: Samantha HarrisonMarla BeauchampKathryn SibleyTamara AraujoJulia RomanoRoger GoldsteinDina Brooks Source Type: research

Growth and development after oesophageal atresia surgery: Need for long-term multidisciplinary follow-up
Survival rates in oesophageal atresia patients have reached over 90%. In long-term follow-up studies the focus has shifted from purely surgical or gastrointestinal evaluation to a multidisciplinary approach. We reviewed the literature on the long-term morbidity of these patients and discuss mainly issues of physical growth and neurodevelopment. We conclude that growth problems–both stunting and wasting–are frequently seen, but that sufficient longitudinal data are lacking. Therefore, it is unclear whether catch-up growth into adolescence and adulthood occurs. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - July 23, 2015 Category: Respiratory Medicine Authors: Hanneke IJsselstijn, Saskia J Gischler, Leontien Toussaint, Marjolein Spoel, Monique HM van der Cammen-van Zijp, Dick Tibboel Source Type: research

Reversibility of pulmonary function after inhaling salbutamol in different doses and body postures in asthmatic children
Pulmonary medication is often delivered in the form of medical aerosols designed for inhalation. Recently, breath actuated inhalers (BAI’s) gained popularity as they can be used without spacers. A major drawback of BAI’s is the impaction in the upper airway. Stretching the upper airway by a forward leaning body posture with the neck extended (“sniffing position”) during inhalation may reduce upper airway impaction and improve pulmonary deposition. Aim of this study was to investigate the reversibility of lung function with different doses salbutamol inhaled with a BAI in the forward leaning posture compared to the ...
Source: Respiratory Medicine CME - July 23, 2015 Category: Respiratory Medicine Authors: R. Visser, S. Kelderman, F.H.C. de Jongh, J. van der Palen, B.J. Thio Source Type: research

A randomized controlled trial of vitamin D replacement strategies in pediatric CF patients
Vitamin D insufficiency is common in children with cystic fibrosis (CF), yet data are sparse regarding the most effective form of vitamin D supplementation. The aim of this study was to compare two different vitamin D replacement regimens. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 23, 2015 Category: Respiratory Medicine Authors: Tregony Simoneau, Gregory S. Sawicki, Carly E. Milliren, Henry A. Feldman, Catherine M. Gordon Tags: Original Article Source Type: research

Optical coherence tomography detects structural abnormalities of the nasal mucosa in patients with cystic fibrosis
Chronic inflammation and remodeling of the airways remain a hallmark of cystic fibrosis (CF). However, knowledge of the associated mucosal micro-anatomical changes is limited. We evaluated the potential of optical coherence tomography (OCT) for in vivo imaging of the upper airway mucosa in CF patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - July 23, 2015 Category: Respiratory Medicine Authors: Ute Oltmanns, Karin Palmowski, Mark Wielpütz, Nicolas Kahn, Eva Baroke, Ralf Eberhardt, Sabine Wege, Matthias Wiebel, Michael Kreuter, Felix J.F. Herth, Marcus A. Mall Tags: Original Article Source Type: research

ASTHMA and COPD: Interchangeable use of inhalers. A document of Italian Society of Allergy, Asthma and Clinical Immmunology (SIAAIC) & Italian Society of Respiratory Medicine (SIMeR)
Publication date: Available online 22 July 2015 Source:Pulmonary Pharmacology &amp; Therapeutics Author(s): Federico Lavorini, Fulvio Braido, Ilaria Baiardini, Francesco Blasi, Giorgio Walter Canonica Prescription cost-containment measures are increasing in many European countries and, as more inhaler devices become available, there may be pressure to switch patients from reference listed inhaler medication to cheaper generic inhaler drugs. Indeed, in some countries, such a substitution is mandated by current regulations, and patients who do not accept the substitution have to pay the difference in cost. Generic...
Source: Pulmonary Pharmacology and Therapeutics - July 23, 2015 Category: Respiratory Medicine Source Type: research

Risk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Wenjia Chen, Jamie Thomas, Mohsen Sadatsafavi, J Mark FitzGerald Background Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disorder associated with increased comorbid prevalence of cardiovascular diseases. We aimed to quantify the magnitudes of association between overall and specific types of cardiovascular disease, major cardiovascular risk factors, and COPD. Methods We searched Cochrane, Medline, and Embase databases for studies published between Jan 1, 1980, and April 30, 2015, on the preval...
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Should countries implement Xpert MTB/RIF when empirical treatment precludes a clinical effect?
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Annelies Van Rie (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Social network analysis of Pseudomonas aeruginosa in cystic fibrosis
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): David C Taylor-Robinson, Kevin W Southern, Craig Winstanley (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

A new phase of CFTR treatment for cystic fibrosis?
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Scott C Bell (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research

Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: a prospective burden of disease study with a nested randomised controlled trial
Publication date: Available online 22 July 2015 Source:The Lancet Respiratory Medicine Author(s): Gregory L Calligaro, Grant Theron, Hoosain Khalfey, Jonathan Peter, Richard Meldau, Brian Matinyenya, Malika Davids, Liezel Smith, Anil Pooran, Maia Lesosky, Aliasgar Esmail, Malcolm G Miller, Jenna Piercy, Lancelot Michell, Rodney Dawson, Richard I Raine, Ivan Joubert, Keertan Dheda Background There are few prospective data about the incidence and mortality associated with pulmonary tuberculosis in intensive care units (ICUs), and none on the accuracy and clinical effect of the Xpert-MTB/RIF assay in this ...
Source: The Lancet Respiratory Medicine - July 23, 2015 Category: Respiratory Medicine Source Type: research