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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Increased CD8 T‐cell granzyme B in COPD is suppressed by treatment with low‐dose azithromycin
ConclusionsWe provide further evidence for the application of low‐dose azithromycin as an attractive adjunct treatment option for controlling epithelial cell apoptosis, abnormal airway repair and chronic inflammation in COPD. (Source: Respirology)
Source: Respirology - October 13, 2014 Category: Respiratory Medicine Authors: Sandra Hodge, Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N. Reynolds Tags: Original Article Source Type: research

Partial palivizumab prophylaxis and increased risk of hospitalization due to respiratory syncytial virus in a medicaid population: a retrospective cohort analysis
Conclusions: RSV-related hospitalization rates were significantly higher in high-risk Medicaid infants with partial palivizumab prophylaxis compared with fully prophylaxed infants. These findings suggest that reduced and/or delayed dosing is less effective. (Source: BMC Pediatrics)
Source: BMC Pediatrics - October 13, 2014 Category: Pediatrics Authors: Leonard KrilovAnthony MasaquelLeonard WeinerDavid SmithSally WadeParthiv Mahadevia Source Type: research

Histone Deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma
ConclusionThe histone deacetylase inhibitor TSA can regulate the balance of Th17/Treg in asthma by regulating the activity of histone deacetylase. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Xiaoxia Hou, Huanying Wan, Xiangyan Ai, Yuheng Shi, Yingmeng Ni, Wei Tang, Guochao Shi Tags: Original Article Source Type: research

Safety of interventional bronchoscopy through complication review at a cancer center
ConclusionThe complication rate with regards to bronchoscopy is comparable to historical controls according to the related literature, and their occurrence appears to be sporadic, not relevant to patient characteristics and mostly related to the bronchoscopy itself rather than the introduction of new techniques. Bronchoscopy remains safe along with technical innovations. However, risk recognition and effective prevention is essential. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Li‐Han Hsu, Chia‐Chuan Liu, Jen‐Sheng Ko, Chao‐Chun Chen, An‐Chen Feng Tags: Original Article Source Type: research

Autoimmune Symptoms in Idiopathic Pulmonary Fibrosis: Clinical Significance
ConclusionsIt appears that autoimmune symptoms are associated with better prognosis among IPF patients. However, future studies are needed to validate our findings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Esam H. Alhamad, Joseph G. Cal, Ahmad A. AlBoukai, Shaffi A. Shaik, Mohammed A Omair Tags: Original Article Source Type: research

Comparison of Pressure‐ and Volume‐Controlled Ventilation in Laparoscopic Cholecystectomy Operations
ConclusionIn this study, with volume‐controlled ventilation anesthesia in laparoscopic cholecystectomy, higher tidal volume and lower alveolar‐arterial oxygen gradient were achieved after pneumoperitoneum. These findings indicated that VCV mode can provide a better alveolar ventilation than PCV mode in laparoscopic cholecystectomy operations. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Venera Aydın, Hanife Karakaya Kabukcu, Nursel Sahin, Ayhan Mesci, Ayse Gulbin Arici, Gulsum Kahveci, Ozgen Ozmete Tags: Original Article Source Type: research

A meta‐analysis: Is low‐dose computed tomography a superior method for risky lung cancers screening population?
ConclusionAmong the risky population, LDCT screening find out more stage I lung cancers and total lung cancers, compared with Chest X‐ray or no screening, and also shows advantages in decreasing lung cancer‐specific mortality, but the screening method does not decrease all cause mortality and have a higher false‐positive rates in diagnosis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Cuiping Fu, Zilong Liu, Fen Zhu, Shanqun Li, Liyan Jiang Tags: Other Source Type: research

Cytokine response to the 6‐minute walk test in individuals with different degrees of COPD
ConclusionAfter the 6MWT, a discrete inflammatory response was observed in COPD patients, independent of the degree of severity. The results concerning IL‐4 and IL‐6 levels can be indicative of an attempt to control inflammation after the 6MWT in COPD patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Gilson Pires Dorneles, Priscila Vianna, Diego Del Duca Lima, Lucas Galant, Alexandre Simões Dias, José Artur Bogo Chies, Mariane Borba Monteiro, Alessandra Peres Tags: Original Article Source Type: research

A rare case of multinodular pulmonary amyloidosis
We present an unusual case of primary pulmonary multinodular amyloidosis in a middle‐aged woman. She presented our hospital with cough and chest distress only. Results of CT showed multiple nodules with diffused calcification and thick‐walled cavity in bilateral lung parenchyma. It is difficult to distinguish parenchymal nodular amyloidosis from malignant primary lung neoplasm in radiology because of their similar images. Thus, the role of CT‐guided core needle biopsy in diagnosis of pulmonary mutinodular amyloidosis is very important. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Jizhen Feng, Jiamei Li, Chunxiang Ling, Qingwei Liu Tags: Other Source Type: research

Sertraline Hydrochloride Treatment for Patients with Stable Chronic Obstructive Pulmonary Disease Complicated with Depression: A Randomized Controlled Trial
ConclusionsAntidepressant treatment can improve the quality of life and exercise capacity of patients with depression, and it can also improve depression scores, but not lung function. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Yuanqiang He, Yulong Zheng, Chuanqin Xu, Haichen Yang, Ziyu Wang, LiYang Zhou, Yufeng Wan, Donghui Zheng, Jing Zhu Tags: Original Article Source Type: research

Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non‐small‐cell lung cancer in East Chinese Han population
ConclusionsThe results suggested that genetic polymorphisms in XPD‐751, XRCC1‐194, and XRCC1‐399 were related to the risk of non‐small cell lung cancer, among which XPD‐751SNP was responsible for adenocarcinoma, while XRCC1‐194SNP was closely linked to squamous carcinoma. Smoking and XRCC1‐194SNP were risk factors of non‐small cell lung cancer. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Yong Du, Yanchao He, Zhoufang Mei, Ling Qian, Jindong Shi, Zhijun Jie Tags: Original Article Source Type: research

Delays for diagnosis and treatment of lung cancers: a systematic review
Abstract The impact of diagnosis and treatment delays for non‐small cell lung cancer (NSCLC) management is poorly understood, even if the literature on the subject is currently increasing in importance. We have few indicators which can serve as reference for quality assurance actions. Several studies analyzed these delays mostly in a monocentric setting. There is an important variability in the definition of these delays, in the collection methods, and in the results obtained. However, it seems distinctly clear that long delays are frequently observed in less symptomatic patients and, therefore, are accompanied by better...
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Vinas F, Ben Hassine I, Jabot L, Monnet I, Chouaid C Tags: Review Article Source Type: research

Adherence to the Global Initiative for Chronic Obstructive Lung Disease guidelines for management of COPD: A hospital‐ base study
ConclusionThe level of adherence to GOLD guidelines for the management of COPD exacerbation was suboptimal at our teaching hospital. Further improvements in adherence to these guidelines are needed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Seyed Masoom Masoompour, Abbas Mohamadi, Hamideh Mahdaviazad Tags: Original Article Source Type: research

Fiducial marker placement via conventional or electromagnetic navigation bronchoscopy (ENB): An interdisciplinary approach to the curative management of lung cancer
ConclusionFiducial marker placement may be an interesting bronchoscopic technique in the interdisciplinary therapeutic approach to inoperable early stage lung cancer. In the described cases therapy planning was successful and no procedure‐related complications were observed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Lars Hagmeyer, Christina Priegnitz, Martin Kocher, Burkhart Schilcher, Wilfried Budach, Marcel Treml, Sven Stieglitz, Winfried Randerath Tags: Original Article Source Type: research

Mitochondrial dysfunction in rat steatotic liver is due to a defect in Complex‐I making them more susceptible to prolonged cold ischemia
Conclusion: Steatotic livers exhibited an apparent mitochondrial dysfunction through an alteration in C‐I activity, making them more susceptible to prolonged cold ischemia. The clinical‐based IPC protocol used here restored MF in mild hepatic steatosis by attenuating C‐I mediated leak following prolonged cold ischemia but not in livers with moderate or severe steatosis. Liver Transpl , 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - October 13, 2014 Category: Transplant Surgery Authors: Michael J.J. Chu, Anthony J.R. Hickey, Yannan Jiang, Amorita Petzer, Adam S.J.R. Bartlett, Anthony R.J. Phillips Tags: Original Article Source Type: research

Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine
Objective: To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs). Methods: Systematic review and practice recommendation development using the American Academy of Neurology guideline development process. Results: Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic background of the population studied. Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, ex...
Source: Neurology - October 13, 2014 Category: Neurology Authors: Narayanaswami, P., Weiss, M., Selcen, D., David, W., Raynor, E., Carter, G., Wicklund, M., Barohn, R. J., Ensrud, E., Griggs, R. C., Gronseth, G., Amato, A. A. Tags: All Neuromuscular Disease, Developmental disorders, All Rehabilitation, All Genetics SPECIAL ARTICLE Source Type: research

Highlights from this issue
A spring in your lung Bronchoscopic lung volume reduction is very much a hot topic. Hitherto coils have been positioned for contraceptive purposes somewhat distal to the lungs; so are the Gynaecologists making a Putin-like bid for our territory? This month we publish 12-month outcomes after bronchoscopic insertion of a nitinol coil device in patients with emphysema (Hot topic; see page 980). Coils have potential advantages over other techniques as their spring like effect might address loss of elasticity (is there a whole body coil for your editors?) and dynamic airway collapse; they are applicable in the 60% of patients w...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Airwaves Source Type: research

Emphysema: time to say farewell to therapeutic nihilism
It is an interesting time for the management of emphysema. In this condition, destruction of lung parenchyma associated with reduced elastic recoil and dynamic airways closure produce gas trapping and increased operating lung volumes, leading to breathlessness and exercise limitation. It has historically been defined as an irreversible process, which has led to a degree of therapeutic nihilism. One manifestation of this has been the curious neglect of lung volume reduction surgery (LVRS). Clinical guidelines,1 reflecting trial evidence,2 recommend consideration of LVRS in selected patients with upper lobe predominant emphy...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Zoumot, Z., Jordan, S., Hopkinson, N. S. Tags: Open access Editorial Source Type: research

The child is father of the man: the importance of early life influences on lung development
There is a great deal of interest in the early life determinants of lung function as possible determinants of obstructive airways disease through the rest of the life course. Failure to attain maximal lung function in early adult life either alone or coupled with accelerated decline during adulthood could contribute to the substantial burden of morbidity and mortality associated with obstructive airway disease and COPD in later life.1 Longitudinal studies of lung function in unselected populations have suggested that decrements of FEV1 established in the first few years after birth track to adulthood,2 thus pointing to ear...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Henderson, A. J. Tags: Editorial Source Type: research

Antioxidants and respiratory disease: the uric acid paradox
For humble individuals like myself, there is one poor comfort, which is this, viz. that gout, unlike any other disease, kills more rich men than poor, more wise men than simple. Thomas Sydenham. In clinical practice, high blood concentrations of uric acid (UA) are generally thought to be a bad thing—primarily because of the risk of gout, but also because individuals with high UA concentrations are at increased risk of cardiovascular disease, metabolic syndrome and hypertension1; these associations may reflect the fact that, under certain circumstances, UA can be pro-oxidant.2 Perhaps less appreciated are the potentia...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Shaheen, S. O. Tags: Editorial Source Type: research

Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial
Conclusions LVR coil treatment results in significant clinical improvements in patients with severe emphysema, with a good safety profile and sustained results for up to 1 year. Trial registration number: NCT01328899. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Deslee, G., Klooster, K., Hetzel, M., Stanzel, F., Kessler, R., Marquette, C.-H., Witt, C., Blaas, S., Gesierich, W., Herth, F. J. F., Hetzel, J., van Rikxoort, E. M., Slebos, D.-J. Tags: Hemoptysis, Open access, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine), Cardiothoracic surgery Chronic obstructive pulmonary disease Source Type: research

Comparison of spatially matched airways reveals thinner airway walls in COPD. The Multi-Ethnic Study of Atherosclerosis (MESA) COPD Study and the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS)
Conclusions Airway walls are thinner in COPD when comparing spatially matched central airways. Other approaches to airway sampling result in comparisons of more proximal to more distal airways and potentially biased assessment of airway properties in COPD. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Smith, B. M., Hoffman, E. A., Rabinowitz, D., Bleecker, E., Christenson, S., Couper, D., Donohue, K. M., Han, M. K., Hansel, N. N., Kanner, R. E., Kleerup, E., Rennard, S., Barr, R. G. Tags: Health education, Smoking, Tobacco use Chronic obstructive pulmonary disease Source Type: research

Improving antibiotic prescribing in acute respiratory tract infections
This Norwegian cluster randomised controlled trial assessed the effects of multifaceted educational interventions on antibiotic prescribing for acute respiratory tract infections (RTI) in general practice. Authors of the study hoped to reduce prescription rates and use of broad spectrum antibiotics with their intervention. Seventy-nine medical education groups, totalling 382 general practitioners (GPs), were recruited in the study. The intervention consisted of two visits by specially trained GPs; one detailing national guidelines for antibiotic use and recent research on acute RTI, and the second to issue reports on indiv...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Eddie, L. Tags: Miscellanea Source Type: research

Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction
Conclusions By using integrative genomics and analysing the relationships of COPD phenotypes with SNPs and gene expression in lung tissue, we identified CST3 and CD22 as potential causal genes for airflow obstruction. This study also augmented the understanding of previously described COPD pathways. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Lamontagne, M., Timens, W., Hao, K., Bosse, Y., Laviolette, M., Steiling, K., Campbell, J. D., Couture, C., Conti, M., Sherwood, K., Hogg, J. C., Brandsma, C.-A., van den Berge, M., Sandford, A., Lam, S., Lenburg, M. E., Spira, A., Pare, P. D., Nickle, D. Tags: Clinical genetics, Genetic screening / counselling Chronic obstructive pulmonary disease Source Type: research

SPLUNC1: link between acidity and dehydration of the airway surface liquid in CF
Short palate lung and nasal epithelial clone 1 (SPLUNC1) is the most abundant secreted protein in the airways and helps maintain a normal airway surface liquid (ASL) volume through its regulation of the epithelial Na+ channel (ENaC). In cystic fibrosis (CF), it has been proposed that increased Na+ absorption by ENaC contributes to ASL depletion, despite the presence of SPLUNC1. The study by Garland et al showed the pH of nasal secretions from CF subjects (pH~6.5) was more acidic than non-CF subjects (pH~7.2), consistent with previous studies of CF ASL. Re-creating such conditions in vitro, the investigators found that alka...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Garnett, J. P. Tags: Miscellanea Source Type: research

Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts
Conclusions Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Cai, Y., Schikowski, T., Adam, M., Buschka, A., Carsin, A.-E., Jacquemin, B., Marcon, A., Sanchez, M., Vierkotter, A., Al-Kanaani, Z., Beelen, R., Birk, M., Brunekreef, B., Cirach, M., Clavel-Chapelon, F., Declercq, C., de Hoogh, K., de Nazelle, A., Ducre Tags: Epidemiologic studies, TB and other respiratory infections, Bronchitis, Air pollution, Environmental issues, Health education, Smoking, Tobacco use Environmental exposure Source Type: research

A longitudinal study of lung function from 1 month to 18 years of age
Conclusions Decrements in lung function in 18-year-olds associated with maternal asthma and early onset atopy may be determined by 1 month of age. Low initial lung function in some individuals can ‘recover’ in some settings. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Turner, S., Fielding, S., Mullane, D., Cox, D. W., Goldblatt, J., Landau, L., le Souef, P. Tags: Epidemiologic studies, Child health, Asthma, Health education, Smoking, Tobacco use, Tobacco use (youth) Paediatric lung disease Source Type: research

Serum uric acid and the risk of respiratory disease: a population-based cohort study
Conclusions Low levels of serum uric acid are associated with higher rates of COPD and lung cancer in current smokers after accounting for conventional risk factors. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Horsfall, L. J., Nazareth, I., Petersen, I. Tags: Lung neoplasms, Epidemiologic studies, Open access, Editor's choice, General practice / family medicine, Lung cancer (oncology), Lung cancer (respiratory medicine), Health education, Smoking, Health effects of tobacco use, Tobacco use Respiratory epidem Source Type: research

Coarse particulate matter associated with increased risk of emergency hospital admissions for pneumonia in Hong Kong
Conclusions Short-term PMc exposure is associated with emergency hospitalisations for pneumonia in Hong Kong. Air quality regulation specifically for PMc might be considered. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Qiu, H., Tian, L. W., Pun, V. C., Ho, K.-f., Wong, T. W., Yu, I. T. S. Tags: Emergency medicine, Epidemiologic studies, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine), Environmental issues Respiratory epidemiology Source Type: research

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia
Conclusions In sharp contrast to its previously reported host-protective role in several infections, the present results reveal that in a model of CAP, MRP8/14 is misused by S. pneumoniae, facilitating bacterial growth by attenuating zinc toxicity toward the pathogen. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Achouiti, A., Vogl, T., Endeman, H., Mortensen, B. L., Laterre, P.-F., Wittebole, X., van Zoelen, M. A. D., Zhang, Y., Hoogerwerf, J. J., Florquin, S., Schultz, M. J., Grutters, J. C., Biesma, D. H., Roth, J., Skaar, E. P., van 't Veer, C., de Vos, A. F., Tags: Pneumonia (infectious disease), TB and other respiratory infections, Inflammation, Pneumonia (respiratory medicine) Source Type: research

Heterogeneity's ruses: the neglected role of between-individual variability in longitudinal studies of COPD exacerbations
ABSTRACT Studying the causal and temporal association between past and future exacerbations in COPD is an active area of research. Standard survival analysis techniques often used in such studies typically produce results that pertain to the overall population, whereas the greatest interest is in the study of associations within individuals. A factor that can lead to profound discrepancies between population-level and individual-level survival patterns is the between-individual heterogeneity in the rate of exacerbations. We briefly review two studies that, while reporting valid results for the overall population, drew conc...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Sadatsafavi, M., FitzGerald, J. M. Tags: Epidemiologic studies, Open access Research letter Source Type: research