Medicine RSS Search Engine

Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

New steps for the international consolidation of the Brazilian Journal of Pulmonology
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Brazilian recommendations of mechanical ventilation 2013. Part I
Perspectives on invasive and noninvasive ventilatory support for critically ill patients are evolving, as much evidence indicates that ventilation may have positive effects on patient survival and the quality of the care provided in intensive care units in Brazil. For those reasons, the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB) and the Brazilian Thoracic Society (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT), represented by the Mechanical Ventilation Committee and the Commission of Intensive Therapy, respectively, decided to review the literature and ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Risk factors for death in patients with severe asthma
CONCLUSIONS: In this cohort of outpatients with severe asthma, the deaths occurred predominantly due to respiratory causes and within a health care facility. Lack of asthma control and male gender were risk factors for mortality. OBJETIVO: Identificar os fatores de risco para morte em pacientes com asma grave. MÉTODOS: Estudo caso-controle aninhado a uma coorte de pacientes acompanhados no Ambulatório Central de Referência do Programa para o Controle da Asma na Bahia, em Salvador (BA). No período entre dezembro de 2002 e dezembro de 2010, foram selecionados todos os pacientes com asma grave que foram a óbito e pacie...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Evaluation of von Willebrand factor in COPD patients
CONCLUSIONS: Our results suggest that increases in vWF levels and activity contribute to the persistence of systemic inflammation, as well as increasing cardiovascular risk, in COPD patients. OBJETIVO: Comparar os níveis séricos absolutos e a atividade sérica em percentual do fator de von Willebrand (FvW) em pacientes com DPOC clinicamente estáveis, tabagistas sem obstrução das vias aéreas e em indivíduos saudáveis que nunca fumaram. MÉTODOS: Foram incluídos no estudo 57 indivíduos, em três grupos: DPOC (n = 36), tabagista (n = 12) e controle (n = 9). Todos os participantes realizaram radiografia do tórax, ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules
CONCLUSIONS: In our sample, CT and CT-PTNB were useful in distinguishing between malignant and benign IPNs. Advanced age and smoking were significantly associated with malignancy. Certain CT findings related to IPNs (larger diameter, spiculated borders, homogeneous attenuation, and necrosis) were associated with malignancy. OBJETIVO: Investigar a aplicação clínica da TC e da biópsia transtorácica percutânea guiada por TC (BTP-TC) em pacientes com nódulos pulmonares indeterminados (NPIs). MÉTODOS: Foram estudados retrospectivamente 113 pacientes portadores de NPIs submetidos a TC e BTP-TC. Foram analisadas variáv...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Comparison between two thoracotomy closure techniques: postoperative pain and pulmonary function
CONCLUSIONS: The patients in the TS group experienced less immediate and late post-thoracotomy pain than did those in the PS group, as well as showing smaller reductions in the spirometry parameters. Therefore, transcostal suture is recommended over pericostal suture as the thoracotomy closure technique of choice. OBJETIVO: Comparar duas técnicas de fechamento de toracotomias (sutura pericostal e transcostal) em relação à dor pós-operatória e função pulmonar. MÉTODOS: Estudo prospectivo, randomizado e duplo-cego realizado no Serviço de Cirurgia Torácica do Hospital das Clínicas Luzia de Pinho Melo e na Univers...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Comparison between reference values for FVC, FEV1, and FEV1/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012
CONCLUSIONS: The predicted values suggested by the GLI equations for White adults were significantly lower than those used as reference values for males in Brazil. For both genders, the lower limit of the FEV1/FVC ratio is significantly lower than that predicted by the GLI equations. OBJETIVO: Comparar os valores espirométricos previstos pelas equações da Global Lung Function Initiative (GLI) em 2012, sugeridas como de uso internacional, com aqueles obtidos em uma amostra utilizada para derivação de valores de referência em adultos caucasianos brasileiros. MÉTODOS: A amostra utilizada era composta por 270 homens e...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Anemia in hospitalized patients with pulmonary tuberculosis
CONCLUSIONS: In this sample, high proportions of pulmonary tuberculosis patients were classified as underweight and malnourished, and there was a high prevalence of anemia of chronic disease. In addition, anemia was associated with high ESR and malnutrition. OBJETIVO: Descrever a prevalência de anemia e de seus tipos em pacientes internados com tuberculose pulmonar. MÉTODOS: Estudo descritivo e longitudinal com pacientes com tuberculose pulmonar hospitalizados em dois hospitais de referência na cidade do Rio de Janeiro (RJ). Foram avaliados o índice de massa corpórea (IMC), dobra cutânea tricipital (DCT), área musc...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Oxidative damage induced by cigarette smoke exposure in mice: impact on lung tissue and diaphragm muscle,
CONCLUSION: Our data demonstrate that CS exposure produces oxidative damage, not only in lung tissue but also (primarily) in muscle tissue, having an additional effect on respiratory muscle, as is frequently observed in smokers with COPD. OBJETIVO: Avaliar o dano oxidativo (oxidação lipídica, oxidação proteica, thiobarbituric acid-reactive substances [TBARS, substâncias reativas ao ácido tiobarbitúrico], e carbonilação) e inflamação (expressão de phosphorylated AMP-activated protein kinase e de phosphorylated mammalian target of rapamycin (p-AMPK e p-mTOR, respectivamente) em tecido pulmonar e músculos do dia...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats
We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.Nosso objetivo foi determinar os nív...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Overview of the biochemical and genetic processes in malignant mesothelioma
The objective of this study was to review the literature regarding the processes of malignant transformation, as well as the respective mechanisms of tumorigenesis, in MM.O mesotelioma maligno (MM) é um câncer extremamente agressivo, com elevado período de latência e resistente aos protocolos de quimioterapia, além de ser extremamente fatal, com taxa de sobrevivência média inferior a um ano. O desenvolvimento do MM é fortemente correlacionado com a exposição ao amianto e erionita, assim como ao vírus símio 40. Apesar de vários países terem banido o uso de amianto, o MM tem se mostrado de difícil controle e s...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Use of volume-targeted non-invasive bilevel positive airway pressure ventilation in a patient with amyotrophic lateral sclerosis,
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Accessory cardiac bronchus causing recurrent pulmonary infection
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Ground-glass nodules and CT-guided placement of platinum coils
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Possible respiratory virus affecting children spreads to Alabama
A still unidentified respiratory illness that has been sweeping through parts of the midwest and pockets of the South has reached Alabama, according to a report from AL.com. Although the virus has not been confirmed, Dr. David Kimberlin, co-director of the University of Alabama at Birmingham Division of Pediatric Infectious Diseases at Children's Hospital, says that early tests show Enterovirus 68 could be responsible for the surge in respiratory-related ER admissions. "Since the latter part of… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - September 9, 2014 Category: Pharmaceuticals Authors: Alan Alexander Source Type: research

NO Binding to the Proapoptotic Cytochrome c-Cardiolipin Complex.
Abstract Cytochrome c is a heme protein that is localized in the compartment between the inner and outer mitochondrial membranes where it functions to transfer electrons between complex III and complex IV of the respiratory chain. It can also form an intimate association with the mitochondrion-specific phospholipid cardiolipin that induces a conformational change in the protein enabling it to act as a peroxidase catalyzing the oxidation of cardiolipin and thereby instigating a chain of events that leads to apoptosis. Unlike the native protein, cytochrome c within the complex binds ligands rapidly; in particular, NO...
Source: Vitamins and Hormones - September 9, 2014 Category: Endocrinology Authors: Hough MA, Silkstone G, Worrall JA, Wilson MT Tags: Vitam Horm Source Type: research

CAT correlates positively with respiratory rate and is a significant predictor of the impact of COPD on daily life of patients: a cross sectional study
Conclusion: The CAT is a sensitive tool to assess the current health status of COPD patients, and in Southern Brazil it is positively correlated with respiratory rate. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - September 9, 2014 Category: Epidemiology Authors: Cíntia BeckerJanaína SchäferLisiane L CarvalhoIsabel P VitielloAndréa L da Silva Source Type: research

Epithelial basement membrane thickening is related to TGF‐Beta 1 expression in children with chronic respiratory diseases
ConclusionsIncreased BM thickness and number of TGF‐β1 positive epithelial cells were found in children with asthma, CF and PCD. The number of TGF‐β1 positive cells correlated positively with the BM thickness in all groups. We suggest that this might be a common generic feature of bronchial remodelling in chronic respiratory diseases.This article is protected by copyright. All rights reserved. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - September 9, 2014 Category: Allergy & Immunology Authors: Lenka Hoňková, Jiří Uhlík, Katarína Beránková, Tamara Svobodová, Petr Pohunek Tags: Original Source Type: research

Anthropometric characteristics and comorbidities in Japanese patients with neurofibromatosis type 1: A single institutional case–control study
This study aimed to characterize NF1 further by investigating its association with anthropometric characteristics and other diseases. We performed a case–control study of 227 NF1 patients (101 male, 126 female) and a randomly selected age‐ and sex‐matched control group of 681 non‐NF1 patients (303 male, 378 female) who visited our institution in Japan. We examined adult (≥20 years) height and body mass index (BMI), and, in the total sample, allergic diseases (bronchial asthma [BA], atopic dermatitis [AD] and allergic rhinitis) and other respiratory cardiovascular and psychiatric disorders. In adults, the mean BM...
Source: The Journal of Dermatology - September 9, 2014 Category: Dermatology Authors: Monji Koga, Kaori Koga, Juichiro Nakayama, Shinichi Imafuku Tags: Original Article Source Type: research

Considering age when making treatment decisions in the ICU: too little, too much, or just right?
This study raises the important question about the contributors to this association, and the authors raise the possibility that physician or surrogate bias may be contributing to decisions for older patients. While this is unlikely to be the only contributor to the association between age and end-of-life decisions, the mere possibility should prompt reflection on the part of clinicians caring for critically ill patients. (Source: Critical Care)
Source: Critical Care - September 9, 2014 Category: Intensive Care Authors: William Ehlenbach Source Type: research

RSV attenuation by codon-pair deoptimization [Microbiology]
Human respiratory syncytial virus (RSV) is the most important viral agent of serious pediatric respiratory-tract disease worldwide. A vaccine or generally effective antiviral drug is not yet available. We designed new live attenuated RSV vaccine candidates by codon-pair deoptimization (CPD). Specifically, viral ORFs were recoded by rearranging existing synonymous codons... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 9, 2014 Category: Science Authors: Le Nouen, C., Brock, L. G., Luongo, C., McCarty, T., Yang, L., Mehedi, M., Wimmer, E., Mueller, S., Collins, P. L., Buchholz, U. J., DiNapoli, J. M. Tags: Biological Sciences Source Type: research

Multicenter Comparison of Emergency Release Group A versus AB Plasma in Blunt‐Injured Trauma Patients
ConclusionUtilization of Group A plasma for emergency blood resuscitation is a safe option which may alleviate potential shortages of AB plasma. (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - September 9, 2014 Category: Biomedical Science Authors: Martin D. Zielinski, Jason J. Schrager, Pamela Johnson, James R. Stubbs, Stephanie Polites, Scott P. Zietlow, Donald H. Jenkins, Bryce R.H. Robinson Tags: Article Source Type: research

Influenza and other respiratory virus infections in solid organ transplant recipients
This article reviews the clinical manifestations of CARVs infections and summarizes the evidence‐based recommendations on the preventive and therapeutic strategies to decrease the burden of these viral infections in SOT recipients. (Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - September 9, 2014 Category: Microbiology Authors: O. Manuel, F. López‐Medrano, L. Kaiser, T. Welte, J. Carratalà, E. Cordero, H. H. Hirsch, Tags: Review Source Type: research

Sphingosine‐1‐phosphate mediates COX‐2 expression and PGE2/IL‐6 secretion via c‐Src‐dependent AP‐1 activation
Sphingosine‐1‐phosphate (S1P) has been shown to regulate cyclooxygenase‐2 (COX‐2)/prostaglandin E2 (PGE2) expression and IL‐6 secretion in various respiratory diseases. However, the mechanisms underlying S1P‐induced COX‐2 expression and PGE2 production in human tracheal smooth muscle cells (HTSMCs) remain unclear. Here we demonstrated that S1P markedly induced COX‐2 expression. S1P also induced PGE2 and IL‐6 secretion which were reduced by the inhibitors of COX‐2 (NS‐398 and celecoxib). Pretreatment with the inhibitor of S1PR1 (W123), S1PR3 (CAY10444), c‐Src (PP1), PYK2 (PF431396), MEK1/2 (U0126), p...
Source: Journal of Cellular Physiology - September 9, 2014 Category: Cytology Authors: Chih‐Kai Hsu, I‐Ta Lee, Chih‐Chung Lin, Li‐Der Hsiao, Chuen‐Mao Yang Tags: Original Research Article Source Type: research

Consider EV-D68 when treating severe respiratory infections [NEWS AND FEATURES]
(Source: AAP News)
Source: AAP News - September 9, 2014 Category: Pediatrics Tags: Infectious Diseases NEWS AND FEATURES Source Type: research

Novel Tests for Diagnosis of Invasive Aspergillosis in Patients with Underlying Respiratory Diseases.
Conclusion Probable or proven invasive pulmonary aspergillosis was diagnosed in 14% of our study population and associated with significantly higher 30-day mortality rates. While the performance of beta-d-glucan was limited by low specificity, and that of mycological culture by low sensitivity, the Aspergillus lateral-flow device seems to be a promising alternative to galactomannan testing that remains the diagnostic gold standard for aspergillosis. Clinical trial registration available at www.clinicaltrials.gov, ID NCT02058316. PMID: 25203869 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 9, 2014 Category: Respiratory Medicine Authors: Prattes J, Flick H, Prüller F, Koidl C, Raggam RB, Palfner M, Eigl S, Buzina W, Zollner-Schwetz I, Thornton CR, Krause R, Hoenigl M Tags: Am J Respir Crit Care Med Source Type: research

Should mammalian target of rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation?
Abstract Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease characterized by proliferation of smooth muscle like cells (LAM cells) that have mutations in the tuberous sclerosis gene (TSC2), leading to the activation of the mammalian target of rapamycin (mTOR). Rapamycin, an inhibitor of the mTOR pathway, has been shown in a landmark clinical trial to halt the decline in lung function, as long as it is used continuously. Women with severe pulmonary LAM still progress to require lung transplantation. The use of inhibitors of the mTOR pathway immediately after transplant has been linked to bronchial anastomo...
Source: Respiratory Care - September 9, 2014 Category: Respiratory Medicine Authors: El-Chemaly S, Goldberg HJ, Glanville AR Tags: Expert Rev Respir Med Source Type: research

CARE OF GUILLAIN-BARRe SYNDROME AFTER ICU DISCHARGE
We present a review of 20 patients managed in a tertiary referral centre over 12 years. The mean age of patients was 59.3 years with a marked male predominance. All had tracheostomy at the time of transfer. The duration of mechanical ventilation between the onset and the time of transfer varied between 45–489 days. The time from admission to decanulation varied from 1–118 days. 19 patients were successfully weaned from invasive ventilatory support, 5 required non-invasive (NIV) nocturnal support for 10–225 days, one has continued to use ongoing nocturnal NIV and one patient died. 19 patients were successf...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Howard, R., Sanctuary, T., Steier, J., Hart, N. Tags: Abstracts Source Type: research

The multidisciplinary adult ataxia telangiectasia service
Conclusion In a rare degenerative neurological condition re-evaluation by a specialist MDT, whilst not affecting disease progression, leads to novel interventions to improve patient care. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Stavrou, M., Bull, T., Thaivalappil, F., Oscroft, N. Tags: Abstracts Source Type: research

Ivig in nmo refractory/intolerant to rituximab
Conclusions IVIG seems to be effective in preventing NMO relapses. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Elsone, L., Mutch, K., Jacob, A. Tags: Abstracts Source Type: research

Non-invasive ventilation in mnd patients in west of scotland
Conclusions Referrals to WoSLTVU increased significantly following NICE guideline publication. NIV lengthened survival by 11 months. This highlights the importance of respiratory support and need for early engagement with respiratory services for the multidisciplinary care of MND patients. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Law, S., Murphy, G., Clarke, A., Ferguson, C., Gorrie, G., Davidson, S. Tags: Abstracts Source Type: research

Role of cough augmentation in amyotrophic lateral sclerosis
Background There is no clear consensus about how best to enhance cough in patients with ALS. Methodology 40 eligible ALS patients with respiratory failure were randomised to the breath-stacking BS technique (n=21) or to mechanical insufflator/exsufflator MI-E (n=19). Findings There were 13 episodes of chest infection in the BS group and 19 episodes in MI-E group (p=0.92), requiring 90 and 95 days of antibiotics respectively (p=0.34). The mean duration of symptoms per chest infection was 6.9 days in the BS group and 3.9 days in MI-E group (p=0.16). There were six episodes of hospitalisation in each group (p=0.64). The cha...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Rafiq, M. K., Bradburn, M., Proctor, A., Billings, C., Bianchi, S., McDermott, C., Shaw, P. Tags: Abstracts Source Type: research

When you hear hooves think percheron horses not zebras
We present two patients with decreased level of consciousness as a result of a stroke. Patient 1: a 73 year old male who presented with a sudden collapse. His GCS was 6 on arrival without any history of seizure. It was unclear whether a cardiac or respiratory arrest caused his collapse. Neurological examination revealed sluggish pupils with miosis on the left and loss of the oculo-cephalic reflex. He could move his limbs spontaneously, with localisation to painful stimuli. Patient 2: a 49 year old female Who presented acutely with drowsiness but no localising signs. She improved slightly by day 4, and referred to Neurology...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Dharia, S., Sittampalam, M., Shah, A., Jones, J., Nor, A. M., Edwards, S. Tags: Abstracts Source Type: research

Activating mutations in stim1 and orai1 cause overlapping syndromes of tubular aggregate myopathy and congenital miosis
We describe the clinical phenotype in five members of an English family (three female), with tubular aggregate myopathy and congenital miosis who were previously described at this meeting 10 years ago (Nicholl DJ et al JNNP 2004;75:1213)and are genealogically linked to other UK families (Shahrizaila et al 2004 Familial myopathy with tubular aggregates associated with abnormal pupils. Neurology 63:1111–13). The phenotype is similar to the previously described Stormorken syndrome (MIM 185070) but without associated thrombocytopathy, asplenia, dyslexia, icthyosis, or migraine. Patients, ranging in age from 22 years to 7...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Nicholl, D., Sadalage, G., Shahrizaila, N., Wills, A., Rose, M., Bremner, F., Wierenga, K. Tags: Abstracts Source Type: research

Sudden unexpected death in adults with m. 3243a>g mutation
Conclusion We propose that sudden unexpected death in asymptomatic individuals with high tissue heteroplasmy represents a new, but rare, phenotype. The exact mechanism of death is undetermined although cardiac cause is a strong possibility. This adds a further challenge to the increasingly complex counselling of asymptomatic carriers of the m.3243A>G mutation. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Ng, Y. S., Lax, N., Schaefer, A., Radunovic, A., Ralph, M., Alhakim, A., Taylor, R., Turnbull, D., McFarland, R., Gorman, G. Tags: Abstracts Source Type: research

Listeria rhombencephalitis--an evolving brainstem syndrome
A 59-year-old man presented with gradual onset left sided facial numbness and vomiting. Over the following 7 days he developed stepwise brainstem deficits including left sided facial weakness, ataxia, nystagmus and bulbar weakness with absent gag reflex. The patient subsequently suffered respiratory arrest and was intubated. CT head was normal and lumbar puncture revealed CSF lymphocytosis with a mildly raised protein. Initial treatment included acyclovir and methylprednisolone. MRI head showed bilateral nodular ring enhancing lesions in the brainstem. The diagnosis of Listeria monocytogenes rhombencephalitis was made foll...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Hrastelj, J., Willis, M., Dawson, K. Tags: Abstracts Source Type: research

Asticcacaulis endophyticus sp. nov., a prosthecate bacterium isolated from the root of Geum aleppicum.
Abstract A strictly aerobic, light-yellow-coloured, stalked bacterium, designated strain ZFGT-14T, was isolated from the root of Geum aleppicum Jacq. collected from Taibai Mountain in Shaanxi Province, north-west China, and was subjected to a taxonomic study by using a polyphasic approach. This novel isolate grew at 7-33 °C (optimum, 25-28 °C) and pH 6.0-10.0 (optimum, pH 7.0-8.0). Flexirubin-type pigments were not produced. Cells were Gram-reaction-negative, rod-shaped and motile with a single polar flagellum. The predominant respiratory quinone was Q-10. The major cellular fatty acids were summed feature 8 (com...
Source: International Journal of Systematic and Evolutionary Microbiology - September 9, 2014 Category: Microbiology Authors: Zhu L, Long M, Si M, Wei L, Li C, Zhao L, Shen X, Wang Y, Zhang L Tags: Int J Syst Evol Microbiol Source Type: research

Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults.
CONCLUSIONS: Compared with non-automated weaning strategies, weaning with SmartCare™ significantly decreased weaning time, time to successful extubation, ICU stay and proportions of patients receiving ventilation for longer than seven days and 21 days. It also showed a favourable trend toward fewer patients receiving ventilation for longer than 14 days; however the estimated effect was imprecise. Summary estimates from our review suggest that these benefits may be achieved without increasing the risk of adverse events, especially reintubation; however, the quality of the evidence ranged from low to moderate, and evidence...
Source: Cochrane Database of Systematic Reviews - September 9, 2014 Category: Journals (General) Authors: Burns KE, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO Tags: Cochrane Database Syst Rev Source Type: research

Haemophilus influenzae oral vaccination for preventing acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease.
CONCLUSIONS: Analyses demonstrate that NTHi oral vaccination of patients with recurrent exacerbations of chronic bronchitis or COPD does not yield a significant reduction in the number and severity of exacerbations. Evidence is mixed and the individual trials that show a significant benefit of the vaccine are too small to advocate widespread oral vaccination of people with COPD. PMID: 25201571 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 9, 2014 Category: Journals (General) Authors: Teo E, House H, Lockhart K, Purchuri SN, Pushparajah J, Cripps AW, van Driel ML Tags: Cochrane Database Syst Rev Source Type: research

Abediterol (LAS100977), a novel long-acting β-agonist: Efficacy, safety and tolerability in persistent asthma
Abediterol (LAS100977) is a novel, long-acting β2-agonist, in development for the once-daily treatment of asthma in combination with mometasone. Here we report the results of a Phase IIa trial of single doses of abediterol added to ongoing maintenance therapy (inhaled corticosteroids) in patients with persistent mild-to-moderate asthma. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - September 9, 2014 Category: Respiratory Medicine Authors: J. Beier, R. Fuhr, E. Massana, E. Jiménez, B. Seoane, G. de Miquel, S. Ruiz Source Type: research

Free-breathing, zero-TE MR lung imaging.
CONCLUSION: Zero-TE appears to be an attractive pulse sequence for 3D isotropic lung imaging. Prospective and retrospective approaches provide high-quality, free-breathing MR lung imaging within reasonable scan time. PMID: 25200814 [PubMed - as supplied by publisher] (Source: Magma)
Source: Magma - September 9, 2014 Category: Radiology Authors: Gibiino F, Sacolick L, Menini A, Landini L, Wiesinger F Tags: MAGMA Source Type: research