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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Safety and efficacy of ustekinumab or golimumab in patients with chronic sarcoidosis.
Abstract Sarcoidosis is characterised by non-caseating granulomas that secrete pro-inflammatory cytokines, including interleukin (IL)-12, IL-23, and tumour necrosis factor (TNF)-α. Ustekinumab and golimumab are monoclonal antibodies that specifically inhibit IL-12/IL-23 and TNF-α, respectively. Patients with chronic pulmonary sarcoidosis (lung group) and/or skin sarcoidosis (skin group) received either 180 mg ustekinumab at week 0 followed by 90 mg every 8 weeks, 200 mg golimumab at week 0 followed by 100 mg every 4 weeks, or placebo. Patients underwent corticosteroid tapering between weeks 16 and 28. The primary...
Source: Respiratory Care - July 17, 2014 Category: Respiratory Medicine Authors: Judson MA, Baughman RP, Costabel U, Drent M, Gibson KF, Raghu G, Shigemitsu H, Barney JB, Culver DA, Hamzeh NY, Wijsenbeek MS, Albera C, Huizar I, Agarwal P, Brodmerkel C, Watt R, Barnathan ES Tags: Eur Respir J Source Type: research

CD14/Toll-like receptors interact with bacteria and regulatory T-cells in the development of childhood asthma.
PMID: 25034561 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 17, 2014 Category: Respiratory Medicine Authors: Klaassen EM, van de Kant KD, Soeteman M, Damoiseaux J, van Eys G, Stobberingh EE, Stelma FF, Quaak M, van Schayck OC, Jöbsis Q, Dompeling E Tags: Eur Respir J Source Type: research

Comprehensive analysis of inflammatory markers in chronic thromboembolic pulmonary hypertension patients.
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with chronic inflammation but the pathological mechanisms are largely unknown. Our study aimed to simultaneously profile a broad range of cytokines in the supernatant of pulmonary endarterectomy (PEA) surgical material, as well as prospectively in patients with CTEPH to investigate whether circulating cytokines are associated with haemodynamic and physical characteristics of CTEPH patients. Herein, we show that PEA specimens revealed a significant upregulation of interleukin (IL)-6, monocyte chemoattractant protein-1, interferon-γ-induced...
Source: Respiratory Care - July 17, 2014 Category: Respiratory Medicine Authors: Zabini D, Heinemann A, Foris V, Nagaraj C, Nierlich P, Bálint Z, Kwapiszewska G, Lang IM, Klepetko W, Olschewski H, Olschewski A Tags: Eur Respir J Source Type: research

Current best practice in the management of pulmonary and systemic sarcoidosis.
Abstract Sarcoidosis is a systemic inflammatory disease of unknown etiology that is characterized by the presence of granulomatous inflammation in affected tissues. It can affect essentially any organ system but shows a predilection for the lungs, eyes, and skin. Accurate epidemiological data are not available in the USA, but sarcoidosis is considered a 'rare disease' (prevalence less than 200,000). However, recent epidemiologic studies indicate that regional prevalence is much higher than previously estimated, especially among African American women. Additionally, mortality rates of patients with sarcoidosis are i...
Source: Respiratory Care - July 17, 2014 Category: Respiratory Medicine Authors: Amin EN, Closser DR, Crouser ED Tags: Ther Adv Respir Dis Source Type: research

Sepsis severe or septic shock: outcome according to the immune status and immunodeficiency profile.
Conclusion:immunodeficiency is common in patients with severe sepsis or septic shock. Despite a similar crude mortality, immunodeficiency was associated with an increased risk of short-term mortality after multivariate analysis. Neutropenia and specific, but not all, profiles of immunodeficiency were independently associated with an increased risk of death. Objective: to evaluate the influence of the immune profile on the outcome at day 28 (D28) of patients admitted in ICU for septic shock or severe sepsis. Materials and Methods: we conducted an observational study using a prospective multicenter database, and incl...
Source: Chest - July 17, 2014 Category: Respiratory Medicine Authors: Tolsma V, Schwebel C, Azoulay E, Darmon M, Souweine B, Vesin A, Goldgran-Toledano D, Lugosi M, Jamali S, Cheval C, Adrie C, Kallel H, Descorps-Declere A, Garrouste-Orgeas M, Bouadma L, Timsit JF Tags: Chest Source Type: research

Prognostic Significance of Visceral Pleural Involvement in Early Stage Lung Cancer.
Conclusions:VPI is a prevalent finding associated with worse prognosis in early-stage lung cancer even among patients with tumors >3 cm in size, a factor not captured in the current staging system. Patients with VPI may be considered candidates for more aggressive treatment. Background: Visceral pleural invasion (VPI) may impact non-small cell lung cancer (NSCLC) survival. However, previous studies are mixed as to whether VPI is an independent prognostic factor in early-stage cancers, and whether its effect is size-dependent. In the current American Joint Committee on Cancer (AJCC) staging system, VPI leads to upsta...
Source: Chest - July 17, 2014 Category: Respiratory Medicine Authors: Lakha S, Gomez JE, Flores RM, Wisnivesky JP Tags: Chest Source Type: research

Undibacterium squillarum sp. nov., isolated from a freshwater shrimp culture pond.
Abstract AA bacterial strain designated CMJ-15T was isolated from a freshwater shrimp culture pond in Taiwan and characterized using a polyphasic taxonomy approach. Cells of strain CMJ-15T were facultatively anaerobic, Gram-stain-negative, motile by a single polar flagellum and forming light yellow-pigmented colonies. Growth occurred at 20-40 °C (optimum, 25-30 °C), with 0-0.7 % NaCl (optimum, 0-0.2 %) and at pH 5.0-9.0 (optimum, pH 6.0-7.0). Phylogenetic analyses based on 16S rRNA gene sequences showed that strain CMJ-15T belonged to the genus Undibacterium and its closest neighbour was Undibacterium oligocarbon...
Source: International Journal of Systematic and Evolutionary Microbiology - July 17, 2014 Category: Microbiology Authors: Sheu SY, Lin YS, Chen JC, Kwon SW, Chen WM Tags: Int J Syst Evol Microbiol Source Type: research

Extracting a respiratory signal from raw dynamic PET data that contain tracer kinetics.
Abstract Data driven gating (DDG) methods provide an alternative to hardware based respiratory gating for PET imaging. Several existing DDG approaches obtain a respiratory signal by observing the change in PET-counts within specific regions of acquired PET data. Currently, these methods do not allow for tracer kinetics which can interfere with the respiratory signal and introduce error. In this work, we produced a DDG method for dynamic PET studies that exhibit tracer kinetics. Our method is based on an existing approach that uses frequency-domain analysis to locate regions within raw PET data that are subject to r...
Source: Medical Physics - July 17, 2014 Category: Physics Authors: Schleyer PJ, Thielemans K, Marsden PK Tags: Phys Med Biol Source Type: research

Risk of suicide and suicide attempts associated with physical disorders: a population-based, balancing score-matched analysis.
CONCLUSIONS: People diagnosed with cancer are at increased risk of suicide, especially in the 3 months following initial diagnosis. Increased support and psychiatric involvement should be considered for the first year after cancer diagnosis. PMID: 25032807 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - July 17, 2014 Category: Psychiatry Authors: Bolton JM, Walld R, Chateau D, Finlayson G, Sareen J Tags: Psychol Med Source Type: research

Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats.
Abstract Exercise capacity and dietary restriction (DR) are linked to improved quality of life, including enhanced brain function and neuro-protection. Brain derived neurotrophic factor (BDNF) is one of the key proteins involved in the beneficial effects of exercise on brain. Low capacity runner (LCR) and high capacity runner (HCR) rats were subjected to DR in order to investigate the regulation of BDNF. HCR-DR rats out-performed other groups in a passive avoidance test. BDNF content increased significantly in the hippocampus of HCR-DR groups compared to control groups (p<0.05). The acetylation of H3 increased s...
Source: Brain Research Bulletin - July 17, 2014 Category: Neurology Authors: Torma F, Bori Z, Koltai E, Felszeghy K, Vacz G, Koch L, Britton S, Boldogh I, Radak Z Tags: Brain Res Bull Source Type: research

Investigating the spill-over hypothesis: Analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators in plasma.
In conclusion, local inflammation in the lung and systemic subclinical inflammation appear mainly independently regulated in elderly women from the general population. Although we found multiple significant correlations between inflammatory biomarkers in sputum and plasma, our results do not provide clear support for the spill-over hypothesis. PMID: 25042033 [PubMed - as supplied by publisher] (Source: Environmental Research)
Source: Environmental Research - July 17, 2014 Category: Environmental Health Authors: Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Hoffmann B, Schulte T, Roden M, Raulf-Heimsoth M, Luckhaus C, Krämer U, Herder C Tags: Environ Res Source Type: research

Myogenin is a positive regulator of MEGF10 expression in skeletal muscle.
Abstract MEGF10 is known to function as a myogenic regulator of satellite cells in skeletal muscle. Mutations in MEGF10 gene cause a congenital myopathy called early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD). Despite its biological importance in muscle physiology, transcriptional regulation of the MEGF10 gene is unknown. Here, we characterized the 5' flanking region of the human MEGF10 gene and showed that the role of myogenic basic helix-loop-helix factor (bHLH) myogenin in MEGF10 transcription in muscle cells. Myogenin was found to share a similar expression pattern with MEGF10 during...
Source: Biochemical and Biophysical Research communications - July 17, 2014 Category: Biochemistry Authors: Park SY, Yun Y, Kim MJ, Kim IS Tags: Biochem Biophys Res Commun Source Type: research

Fighting respiratory diseases: divided efforts lead to weakness
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Translating patient-reported outcome measures: a multi-step process is essential
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Leicester Cough Questionnaire: translation to Portuguese and cross-cultural adaptation for use in Brazil
Conclusions: The final version of the LCQ adapted for use in Brazil was found to be easy to understand and easily applied. Objetivo: Traduzir e adaptar culturalmente o Leicester Cough Questionnaire (LCQ) para a língua portuguesa falada no Brasil. Métodos: A adaptação cultural de um questionário de qualidade de vida envolve a tradução conceitualmente equivalente à versão original e culturalmente aceitável ao país em que será utilizado. O protocolo aplicado consistiu na tradução do LCQ para a língua portuguesa por três tradutores brasileiros com fluência na língua inglesa e sua retradução para a língua ...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Oxygen desaturation during the six-minute walk test in COPD patients
Conclusions: In the sevCOPD group, in comparison with the modCOPD group, SpO2 was lower and the Tmin was greater, suggesting a worse prognosis in the former. Objetivo: Avaliar o comportamento da curva de saturação de oxigênio durante o teste de caminhada de seis minutos (TC6) em pacientes com DPOC. Métodos: Incluímos 85 pacientes e todos realizaram espirometria, sendo classificados como portadores de DPOC moderada (DPOCm, n = 30) ou grave (DPOCg, n = 55). Todos os pacientes realizaram TC6 em um corredor de 27 m com monitoramento contínuo da SpO2 e FC por telemetria. A partir das curvas de SpO2, foram analisados os t...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Hospitalized patients with COPD: analysis of prior treatment
Conclusions: The application of various non-pharmacological management recommendations was unsatisfactory. Regarding the GOLD recommendations, the high rate of inappropriate maintenance treatment was mainly due to undertreatment. In Brazil, even in severe COPD cases, optimizing treatment to achieve greater benefits continues to be a challenge. Objetivo: Embora a DPOC seja uma enfermidade prevalente, ela é subtratada, e dados sobre o tratamento prévio são desconhecidos em nosso meio. Buscou-se verificar a adequação às recentes diretrizes no que se refere ao tratamento de manutenção em pacientes com DPOC antes de sua...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Effects of acute and chronic administration of methylprednisolone on oxidative stress in rat lungs
Conclusions: Our results suggest that the acute use of corticosteroids is beneficial to lung tissue, whereas their chronic use is not. The chronic use of methylprednisolone appears to increase lung LPO levels. Objetivo: Determinar os efeitos da administração aguda e crônica de metilprednisolona no estresse oxidativo, por meio da quantificação da peroxidação lipídica (POL) e do potencial antioxidante reativo total (PART), em pulmões de ratos. Métodos: Quarenta ratos Wistar foram divididos em quatro grupos: tratamento agudo, com ratos recebendo uma dose única de metilprednisolona (50 mg/kg i.p.); controle agudo, ...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Pulmonary function in advanced uncomplicated singleton and twin pregnancy
Conclusions: Despite its higher physiological demands, twin pregnancy does not appear to impair respiratory function to any greater degree than does singleton pregnancy. Objetivo: A gravidez traz mudanças significativas na função respiratória, evidenciada por alterações nos volumes e capacidades pulmonares, que são atribuíveis ao impedimento mecânico causado pelo feto em crescimento. Este estudo foi realizado a fim de identificar alterações na função respiratória durante a gravidez normal e determinar se tais alterações são mais pronunciadas em gestação gemelar que em gestação única. Métodos: Foi av...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Reliability of a rapid hematology stain for sputum cytology
Conclusions: The use of Diff-Quik can be considered a reliable alternative for the processing of sputum samples. Objetivo: Determinar a confiabilidade da coloração hematológica rápida para a análise do escarro induzido. Métodos: Estudo transversal comparando a técnica padrão (coloração May-Grünwald-Giemsa) com a coloração hematológica rápida (panótico rápido). Participaram do estudo 50 indivíduos (21 asmáticos, 19 portadores de DPOC e 10 controles). Após a coleta do escarro induzido, foram preparadas 4 lâminas, sendo 2 coradas por May-Grünwald-Giemsa e 2 por panótico rápido. As lâminas foram lidas...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Indoor air quality and health in schools
Conclusions: Most of the schools evaluated presented with reasonable air quality and thermal comfort. However, the concentrations of various pollutants, especially CO2, suggest the need for corrective interventions, such as reducing air pollutant sources and improving ventilation. There was a statistically significant association between lack of concentration in the children and exposure to high levels of CO2. The overall low level of pollution in the city of Coimbra might explain the lack of other significant associations. Objetivo: Determinar se há uma associação entre a qualidade do ar interno em escolas e a prevalê...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment
Conclusions: Higher serum selenium levels after 60 days of treatment were associated with the conversion of bacteriological tests in pulmonary tuberculosis patients. Objetivo: Determinar se os níveis séricos de selênio estão associados à conversão dos testes bacteriológicos em pacientes diagnosticados com tuberculose pulmonar ativa após oito semanas de tratamento-padrão. Métodos: No início do estudo, avaliamos 35 controles saudáveis, do sexo masculino, e 35 pacientes do sexo masculino com tuberculose pulmonar. Estes foram também avaliados após 30 e 60 dias de tratamento antituberculose. Todos os participante...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Tuberculosis in hospitalized patients: clinical characteristics of patients receiving treatment within the first 24 h after admission
Conclusions: Although tuberculosis treatment was initiated promptly in a considerable proportion of the inpatients evaluated, the rates of in-hospital mortality, ICU admission, and mechanical ventilation use remained high. Strategies for the control of tuberculosis in primary care should consider that patients who seek medical attention at hospitals arrive too late and with advanced disease. It is therefore necessary to implement active surveillance measures in the community for earlier diagnosis and treatment. Objetivo: Comparar as características clínicas e os desfechos de pacientes hospitalizados por tuberculose que i...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Nicotine dependence and smoking habits in patients with head and neck cancer
Conclusions: In most of the patients studied, the level of ND was high or very high. The prevalence of heavy smoking for long periods was high in our sample. A diagnosis of cancer is a motivating factor for smoking cessation. However, intensive smoking cessation treatment is not routinely offered to smoking patients diagnosed with cancer. Objetivo: Avaliar o perfil tabágico (PT) e a dependência nicotínica (DN) em pacientes com câncer de cabeça e pescoço. Métodos: Estudo realizado com 71 pacientes portadores de carcinoma epidermoide de cavidade oral, faringe e laringe, tabagistas ou ex-tabagistas, atendidos em um ho...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Performance of ICU ventilators during noninvasive ventilation with large leaks in a total face mask: a bench study
Conclusions: The majority of the ICU ventilators tested were not suitable for NIV with a leaky TFM. Objetivo: O desconforto e a falta de adaptação às interfaces de ventilação não invasiva (VNI) são obstáculos ao sucesso da VNI. A máscara facial total (MFT) é uma interface de VNI considerada muito confortável. No entanto, devido a seu grande volume interno e, consequentemente, ao aumento da reinalação de CO2, a MFT tem orifícios que permitem vazamentos proximais para melhorar a eliminação de CO2. É possível que os ventiladores usados na UTI não compensem esse vazamento adequadamente. Neste estudo, buscamo...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Combined pulmonary fibrosis and emphysema: an increasingly recognized condition
Combined pulmonary fibrosis and emphysema (CPFE) has been increasingly recognized in the literature. Patients with CPFE are usually heavy smokers or former smokers with concomitant lower lobe fibrosis and upper lobe emphysema on chest HRCT scans. They commonly present with severe breathlessness and low DLCO, despite spirometry showing relatively preserved lung volumes. Moderate to severe pulmonary arterial hypertension is common in such patients, who are also at an increased risk of developing lung cancer. Unfortunately, there is currently no effective treatment for CPFE. In this review, we discuss the current knowledge of...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Simultaneous interstitial pneumonitis and cardiomyopathy induced by venlafaxine
We report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents. Chest CT angiography and chest X-ray revealed parenchymal lung disease (diffuse micronodules and focal ground-glass opacities) and simultaneous dilated cardiomyopathy. Ecocardiography revealed a left ventricular ejection fraction (...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Lung cancer and schwannoma - the pitfalls of positron emission tomography
We report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents. Chest CT angiography and chest X-ray revealed parenchymal lung disease (diffuse micronodules and focal ground-glass opacities) and simultaneous dilated cardiomyopathy. Ecocardiography revealed a left ventricular ejection fraction (...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Unilateral pulmonary agenesis
We report the case of a 35-year-old female patient diagnosed with synchronous pneumonitis and acute cardiomyopathy attributed to venlafaxine. The patient sought medical attention due to dyspnea and dry cough that started three months after initiating treatment with venlafaxine for depression. The patient was concomitantly taking Centella asiatica and Fucus vesiculosus as phytotherapeutic agents. Chest CT angiography and chest X-ray revealed parenchymal lung disease (diffuse micronodules and focal ground-glass opacities) and simultaneous dilated cardiomyopathy. Ecocardiography revealed a left ventricular ejection fraction (...
Source: Jornal Brasileiro de Pneumologia - July 16, 2014 Category: Respiratory Medicine Source Type: research

Correlates of exposure to secondhand smoke (SHS) at home among non-smoking adults in Bangladesh: findings from the ITC Bangladesh survey
Background: Exposure to secondhand smoke (SHS) is a serious global public health problem. Understanding the correlates of SHS exposure could guide the development of evidence based SHS exposure reduction interventions. The purpose of this study is to describe the pattern of and factors associated with SHS exposure among non-smoking adults in Bangladesh. Methods: Data come from adult non-smokers who participated in the second wave (2010) of the International Tobacco Control Policy (ITC) Evaluation Bangladesh Survey conducted in all six administrative divisions of Bangladesh. A structured questionnaire gathered information o...
Source: BMC Pulmonary Medicine - Latest articles - July 16, 2014 Category: Respiratory Medicine Authors: Abu AbdullahPete DriezenGenevieve SansoneNigar NargisGhulam HussainAnne QuahGeoffrey Fong Source Type: research

Nanoparticle uptake by airway phagocytes after fungal spore challenge in murine allergic asthma and chronic bronchitis
Conclusions: Overall, AuNP uptake by BAL macrophages occurred mainly by co-uptake together with other material, including micrometer-sized ambient air particles like fungal spores. The lower percentage of NP containing macrophages in BAL from Scnn1b-Tg mice points to a change in the macrophage population from a highly to a less phagocytic phenotype. This likely contributes to inefficient macrophage clearance of NP in lung disease. Finally, the AuNP containing eosinophils in OVA-allergic mice show that other inflammatory cells present on airway surfaces may substantially contribute to NP uptake. (Source: BMC Pulmonary Medic...
Source: BMC Pulmonary Medicine - Latest articles - July 16, 2014 Category: Respiratory Medicine Authors: Marianne GeiserChristoph WiggeMelanie ConradSylvie Eigeldinger-BerthouLisa KünziHolger GarnHarald RenzMarcus Mall Source Type: research

Pleuromutilins: use in food-producing animals in the European Union, development of resistance and impact on human and animal health
The objective of this review is to summarize the current knowledge on the usage of pleuromutilins, resistance development and the potential impact of this resistance on animal and human health. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 16, 2014 Category: Microbiology Authors: van Duijkeren, E., Greko, C., Pringle, M., Baptiste, K. E., Catry, B., Jukes, H., Moreno, M. A., Pomba, M. C. M. F., Pyorala, S., Rantala, M., Ružauskas, M., Sanders, P., Teale, C., Threlfall, E. J., Torren-Edo, J., Torneke, K. Tags: Review Source Type: research

Impact of implementation of a novel antimicrobial stewardship tool on antibiotic use in nursing homes: a prospective cluster randomized control pilot study
Conclusions This pilot study demonstrated that use of RAMP was associated with a statistically significant decrease in total antibiotic consumption and has the potential to be an important antimicrobial stewardship tool for NHs. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - July 16, 2014 Category: Microbiology Authors: Fleet, E., Gopal Rao, G., Patel, B., Cookson, B., Charlett, A., Bowman, C., Davey, P. Tags: Original research Source Type: research

The impact of rescue or maintenance therapy with EGFR TKIs for Stage IIIb-IV non-squamous non-small-cell lung cancer patients requiring mechanical ventilation
Conclusions: Rescue or maintenance therapy with EGFR TKI for stage IIIb-IV non-squamous NSCLC patients requiring mechanical ventilation was not associated with better outcome. An end-of-life discussion should be an important aspect in the care of this group of patients, since only 19% were successfully weaned from mechanical ventilation. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - July 16, 2014 Category: Anesthesiology Authors: Te-Chun HsiaChih-Yen TuHung-Jen Chen Source Type: research

Genetic ablation of VIAAT in glycinergic neurons causes a severe respiratory phenotype and perinatal death.
Abstract Both glycinergic and GABAergic neurons require the vesicular inhibitory amino acid transporter (VIAAT) for synaptic vesicle filling. Presynaptic GABA concentrations are determined by the GABA-synthesizing enzymes glutamate decarboxylase (GAD)65 and GAD67, whereas the presynaptic glycine content depends on the plasma membrane glycine transporter 2 (GlyT2). Although severely impaired, glycinergic transmission is not completely absent in GlyT2-knockout mice, suggesting that other routes of glycine uptake or de novo synthesis of glycine exist in presynaptic terminals. To investigate the consequences of a compl...
Source: Brain Structure and Function - July 16, 2014 Category: Neuroscience Authors: Rahman J, Besser S, Schnell C, Eulenburg V, Hirrlinger J, Wojcik SM, Hülsmann S Tags: Brain Struct Funct Source Type: research

Combined sputum hypermethylation and eNose analysis for lung cancer diagnosis
Conclusions When used in concert, RASSF1A hypermethylation in sputum and exhaled breath analysis are complementary for lung cancer diagnosis, with 100% sensitivity in this series. This finding should be further validated. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 16, 2014 Category: Pathology Authors: Hubers, A. J., Brinkman, P., Boksem, R. J., Rhodius, R. J., Witte, B. I., Zwinderman, A. H., Heideman, D. A. M., Duin, S., Koning, R., Steenbergen, R. D. M., Snijders, P. J. F., Smit, E. F., Sterk, P. J., Thunnissen, E. Tags: Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research

A cautionary lesson on the use of targeted methods for EGFR mutation analysis: a case report
We report a case where this kit detected an exon 19 deletion, predicting sensitivity to tyrosine kinase inhibitors (TKIs), which on further analysis was found to be a 2 bp indel (c.2239_2240delinsCC, p.(Leu747Pro)). Two of four published cases with this mutation were found to be associated with resistance to EGFR TKI. The sample was also tested using two other commercial kits, one of which indicated a deletion. This is a rare mutation making the erroneous detection of a deletion unlikely; however, it is important that clinical laboratories are aware of the potential failings of two commercial kits for EGFR mutation an...
Source: Journal of Clinical Pathology - July 16, 2014 Category: Pathology Authors: Walsh, K., Wallace, W. A., Butler, R., Mackean, M. J., Harrison, D. J., Stirling, D., Oniscu, A. Tags: Molecular genetics, Lung cancer (oncology), Lung cancer (respiratory medicine) Short report Source Type: research

Long-term smoking increases the need for acute care among asthma patients: a case control study
Conclusions: Asthma patients who are or have been long-term smokers are more likely to require ER care compared to never smokers. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 16, 2014 Category: Respiratory Medicine Authors: Paula KauppiHenna KupiainenAri LindqvistTari HaahtelaTarja Laitinen Source Type: research

Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease
Background: Bronchodilator medications are central to the symptomatic management of chronic obstructive pulmonary disease (COPD). Metered-dose inhalers (MDIs) are the most commonly used devices to deliver treatment to patients with COPD and asthma, comprising approximately 70% of bronchodilator prescriptions. Proprietary porous-particle technology permits the formulation of long-acting muscarinic antagonists, long-acting beta2-agonists, and a combination of both in hydrofluoroalkane (HFA) MDIs, providing a solution to formulation challenges inherent to the development of HFA MDIs, which have contributed to the development ...
Source: BMC Pulmonary Medicine - Latest articles - July 16, 2014 Category: Respiratory Medicine Authors: Stephen RennardCharles FogartyColin ReisnerCarlos FernandezTracy FischerMichael GoldenEarl RosePatrick DarkenGregory TardieChadwick Orevillo Source Type: research

Statins reduce all-cause mortality in chronic obstructive pulmonary disease: a systematic review and meta-analysis of observational studies
Conclusions: The use of statins for patients suffering from chronic obstructive pulmonary disease may reduce all-cause mortality. This conclusion should be re-evaluated by a registered large-scale randomized controlled trial. (Source: Respiratory Research)
Source: Respiratory Research - July 16, 2014 Category: Respiratory Medicine Authors: Nobuyuki HoritaNaoki MiyazawaRyota KojimaMiyo InoueYoshiaki IshigatsuboAtsuhisa UedaTakeshi Kaneko Source Type: research