Respiratory Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Riboflavin deprivation inhibits macrophage viability and activity - a study on the RAW 264.7 cell line.
In conclusion, macrophages are sensitive to riboflavin deficiency; thus, a low riboflavin intake in the diet may affect the immune system and may consequently decrease proper host immune defence. PMID: 23415257 [PubMed - as supplied by publisher]
Source: The British Journal of Nutrition - February 18, 2013 Category: Nutrition Authors: Mazur-Bialy AI, Buchala B, Plytycz B Tags: Br J Nutr Source Type: research

Limitations of climate chamber studies into thermal comfort and workers’ performance
In this study subjects in a climate chamber were exposed to two temperatures: 22 and 30°C. In both conditions the clo‐value was 0.9. The subjects performed mental tests and simulated office work. During and after exposure physiological tests were taken, among them heart rate and respiratory ventilation. © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Source: Indoor Air - February 18, 2013 Category: Occupational Health Authors: Joe L. Leyten, Stanley R. Kurvers Tags: Letter to the Editor Source Type: research

RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus
Messenger RNA encoded signals that are involved in programmed -1 ribosomal frameshifting (-1 PRF) are typically two-stemmed hairpin (H)-type pseudoknots (pks). We previously described an unusual three-stemmed pseudoknot from the severe acute respiratory syndrome (SARS) coronavirus (CoV) that stimulated -1 PRF. The conserved existence of a third stem–loop suggested an important hitherto unknown function. Here we present new information describing structure and function of the third stem of the SARS pseudoknot. We uncovered RNA dimerization through a palindromic sequence embedded in the SARS-CoV Stem 3. Further in vitr...
Source: Nucleic Acids Research - February 18, 2013 Category: Research Authors: Ishimaru, D., Plant, E. P., Sims, A. C., Yount, B. L., Roth, B. M., Eldho, N. V., Perez-Alvarado, G. C., Armbruster, D. W., Baric, R. S., Dinman, J. D., Taylor, D. R., Hennig, M. Tags: RNA Source Type: research

In utero exposure to low dose arsenic via drinking water impairs early life lung mechanics in mice
Conclusions: Exposure to arsenic at the current WHO maximum contaminant level in utero impaired somatic growth and the development of the lungs resulting in alterations to lung mechanics during infancy. Deficits in growth and lung development in early life may contribute to the increased susceptibility of developing chronic respiratory disease in arsenic exposed human populations.
Source: BMC Clinical Pharmacology - February 18, 2013 Category: Drugs & Pharmacology Authors: Kathryn RamseyAlexander LarcombePeter SlyGraeme Zosky Source Type: research

Sexually transmitted diphtheria
This report concerns the first case of sexually transmitted diphtheria in a patient with non-gonococcal urethritis after orogenital contact.
Source: Sexually Transmitted Infections - February 18, 2013 Category: Sexual Medicine Authors: Berger, A., Lensing, C., Konrad, R., Huber, I., Hogardt, M., Sing, A. Tags: Urethritis, Vulvovaginal disorders Clinical Source Type: research

Pirfenidone; can it be a new horizon for the treatment of pulmonary fibrosis in mustard gas-intoxicated patients?
Sulfur mustard is an alkylating substance still regarded as a threat in chemical warfare and terrorism. Lung parenchymal damage occurs in the most severe inhalational exposures. It accompanies an increased risk of respiratory tract carcinomas and chronic respiratory sequelae including chronic bronchitis, bronchiectasis, pulmonary fibrosis, interstitial lung disease, emphysema, and bronchiolitis obliterans. Pirfenidone is an antifibrotic with anti-inflammatory and anti hydroxyl radical activities which stabilizes pulmonary function in idiopathic pulmonary fibrosis patients. It can be suggested in chronically exposed soldier...
Source: BioMed Central - February 18, 2013 Category: Journals (General) Authors: Nasim Zamani Source Type: research

Exhaled nitric oxide in symptomatic children at preschool age predicts later asthma
ConclusionsIn this cohort of high‐risk preschool children, elevated FeNO is associated with increased risk for school‐age asthma. The new API including FeNO identifies children at risk of later asthma comparably to the classical API, but does not require blood sampling.
Source: Allergy - February 18, 2013 Category: Allergy & Immunology Authors: F. Singer, I. Luchsinger, D. Inci, N. Knauer, P. Latzin, J. H. Wildhaber, A. Moeller Tags: Original Article Source Type: research

Crystal structure of the entire respiratory complex I
A. Sazanov Complex I is the first and largest enzyme of the respiratory chain and has a central role in cellular energy production through the coupling of NADH:ubiquinone electron transfer to proton translocation. It is also implicated in many common human neurodegenerative diseases. Here, we report the
Source: Nature - February 17, 2013 Category: Research Authors: Rozbeh BaradaranJohn M. BerrisfordGurdeep S. MinhasLeonid A. Sazanov Tags: Article Source Type: research

Efficacy and safety of ribosome-component immune modulator for preventing recurring respiratory infections in socialized children
This article is currently available as a free download on ingentaconnect
Source: Allergy and Asthma Proceedings - February 16, 2013 Category: Allergy & Immunology Authors: Bergamini, MarcelloSimeone, GiovanniVerga, Maria CarmenFiocchi, AlessandroOmboni, Stefano Tags: Articles Source Type: research

Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia in a challenge study with highly pathogenic PRRSV JX143.
Abstract Porcine reproductive and respiratory syndrome virus (PRRSV) has been confirmed to be the underlying cause of the so-called 'porcine high fever disease' (PHFD), a disease that emerged in China in 2006 and subsequently spread over South East Asia. The aim of this study was to investigate whether animals challenged with the Chinese highly pathogenic PRRSV JX143 would be protected by vaccination with single dose of a type 2 modified live virus (MLV) vaccine. Forty-four pigs 17-19 days of age were weighed and randomly assigned to either vaccination with subsequent challenge (V/C, n=20), challenge only (NV/C, n=...
Source: Vaccine - February 16, 2013 Category: Allergy & Immunology Authors: Wei Z, Zhang J, Zhuang J, Sun Z, Gao F, Yuan S Tags: Vaccine Source Type: research

Acute renal failure potentiates brain energy dysfunction elicited by methylmalonic acid.
Abstract The influence of acute renal failure induced by gentamicin administration on the effects of MMA on mitochondrial respiratory chain complexes, citrate synthase, succinate dehydrogenase and creatine kinase activities in cerebral cortex and kidney of young rats were investigated. Animals received one intraperitoneal injection of saline or gentamicin (70mg/kg). One hour after, the animals received three consecutive subcutaneous injections of MMA (1.67μmol/g) or saline (11hours interval between injections) and 60min after the last injection the animals were killed. Acute MMA administration decreased creatine k...
Source: International Journal of Developmental Neuroscience - February 16, 2013 Category: Neuroscience Authors: Schuck PF, Januário SB, Simon KR, Scaini G, Mafioleti RL, Malgarin F, Pettenuzzo LF, Streck EL, Ferreira GC Tags: Int J Dev Neurosci Source Type: research

Target organ toxicities in studies conducted to support first time in man dosing: an analysis across species and therapy areas.
Abstract An analysis of target organ toxicities in first time in man (FTiM) toxicity studies for 77 AstraZeneca candidate drugs (CDs) was conducted across a range of therapy areas. In the rodent, the most frequently affected organ was the liver followed by adrenal glands, kidney, spleen, bone marrow and thymus. In non-rodent, liver and thymus were the most frequently affected organs, followed closely by the testis and GI tract. The profile of affected organs was largely similar across the therapy areas of respiratory and inflammation, cardiovascular/gastrointestinal and CNS/pain. The oncology/infection therapy area...
Source: Regulatory Toxicology and Pharmacology : RTP - February 16, 2013 Category: Toxicology Authors: Horner S, Ryan D, Robinson S, Callander R, Stamp K, Roberts R Tags: Regul Toxicol Pharmacol Source Type: research

The impact of preterm birth and bronchopulmonary dysplasia on the developing lung: long-term consequences for respiratory health.
Abstract Preterm birth affects 8-10% of human pregnancies and is a major cause of long-term disability. Individuals who are born very preterm, especially if they develop bronchopulmonary dysplasia (BPD), have an increased risk of impaired lung function in infancy, childhood and adulthood, and an increased risk of respiratory illness. Our aim is to briefly review current understanding of the basis for long-term impairments in lung function and respiratory health following preterm birth and BPD. Histopathology of the lungs of infants and children following preterm birth and BPD show altered development of the lung pa...
Source: Clinical and Experimental Pharmacology and Physiology - February 16, 2013 Category: Drugs & Pharmacology Authors: O'Reilly M, Sozo F, Harding R Tags: Clin Exp Pharmacol Physiol Source Type: research

Index
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Source Type: research

Rare Pleural Tumors
Primary pleural tumors other than mesothelioma account for fewer than 1% of all lung cancers, and consequently they pose diagnostic and management challenges. Their treatment must be targeted toward the specific tumor type and is often quite different from the treatment for mesothelioma or metastases. Despite the best efforts at diagnosing and treating these tumors, the prognosis associated with some of the benign and many of the malignant variants of these tumors remains poor. In this review, we describe the radiologic and pathologic features of the less common primary pleural tumors and propose a diagnostic approach to their evaluation.
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Christopher T. Erb, Kelsey M. Johnson, Anthony W. Kim Tags: Section III: Pleural Interventions Source Type: research

Pleuroscopy in 2013
Pleuroscopy provides a window to the pleural space while enabling biopsy of the parietal pleura under direct visual guidance for effusions of unknown etiology, guided chest tube placement, and pleurodesis for recurrent pleural effusions or pneumothoraces in selected patients. The procedure enjoyed resurgence when thoracic surgeons introduced the technique for video-assisted thoracic surgery (VATS). VATS is performed under general anesthesia with single-lung ventilation; pleuroscopy is performed in an endoscopy suite using nondisposable rigid or flex-rigid instruments, local anesthesia, and conscious sedation. Pleuroscopy i...
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Pyng Lee, Henri G. Colt Tags: Section III: Pleural Interventions Source Type: research

Tunneled Pleural Catheters: An Update for 2013
Tunneled pleural catheters (TPCs) are a safe, effective, and well-tolerated option for palliation in patients with malignant pleural effusion (MPEs) on an outpatient basis. TPCs are incorporated into international guidelines for the management of MPEs and appear to be the most cost-effective option according to current data.
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Renelle Myers, Gaetane Michaud Tags: Section III: Pleural Interventions Source Type: research

Defying Gravity: Subdiaphragmatic Causes of Pleural Effusions
Intra-abdominal fluid may migrate readily into the pleural space through naturally occurring holes in the diaphragm or intradiaphragmatic lymphatics. Although any type of fluid in the abdomen may migrate, additional pathologic mechanisms are involved in the development of chylous ascites/chylothorax, yellow nail syndrome, urinothorax, pancreaticopleural fistulas, or other connections. In the differential diagnosis of the large list of potential pleural fluid causes, intra-abdominal sources should be entertained by the practicing physician in the right clinical context.
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Kyle Bramley, Jonathan T. Puchalski Tags: Section II: Analyzing Pleural Fluid Source Type: research

The Evaluation and Clinical Application of Pleural Physiology
This article reviews pleural physiology and summarizes the relevant data supporting the use of ultrasound and manometry in the evaluation and treatment of pleural disease.
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Jason Akulian, Lonny Yarmus, David Feller-Kopman Tags: Section I: Obtaining Pleural Fluid Source Type: research

What I Have Learned in the Past 40 Years
In this special edition of Clinics in Chest Medicine, I was asked to write a prologue about my career and highlight my educational opportunities en route to becoming a Professor of Medicine at Vanderbilt University. I have learned many things in the past 40 years since the publications of the Light criteria for pleural effusions. I have learned what it takes to be successful. I think that successful researchers have several attributes. (1) They are organized. They do not waste time looking for things or repeating things. (2) They are persistent. If a grant or a manuscript gets rejected, they keep trying. (3) In their resea...
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Richard W. Light Source Type: research

Preface
Pleural diseases affect over a million individuals annually, and physicians in most subspecialties encounter pleural effusions. This issue of Clinics in Chest Medicine aims to succinctly define what is, in my opinion, critical to know for clinical practice in 2013. I asked Dr Light to give us insight into what he has learned since the establishment of Light’s criteria 40 years ago, and I invite you to relive his experiences and embrace the “take-home points” from his amazing career.
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Jonathan Puchalski Source Type: research

Forthcoming Issues
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Source Type: research

Contents
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Source Type: research

Contributors
Source: Clinics in Chest Medicine - February 15, 2013 Category: Respiratory Medicine Source Type: research

Mortality Reduction among Pneumonia Patients Still Substantial despite the Impact of Coding Changes
Conclusions: Survival of patients with community-acquired pneumonia has improved greatly over time. However, interpretation of such findings based on administrative data must be made with caution and careful attention to case definition and coding trends.
Source: The American Journal of Medicine - February 15, 2013 Category: Journals (General) Authors: Gregory W. Ruhnke, Marcelo Coca Perraillon, David M. Cutler Tags: Brief observation Source Type: research

Carbamazepine/chlorpromazine/clonazepam overdose: Neurological and respiratory depression and signs of acute respiratory distress syndrome: case report
Source: Reactions - February 15, 2013 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Bacterial Signatures in Thrombus Aspirates of Patients with Myocardial Infarction.
CONCLUSIONS: Dental infection and oral bacteria, especially viridans streptococci may be associated with the development of acute coronary thrombosis. PMID: 23418311 [PubMed - as supplied by publisher]
Source: Circulation - February 15, 2013 Category: Cardiology Authors: Pessi T, Karhunen V, Karjalainen PP, Ylitalo A, Airaksinen JK, Niemi M, Pietila M, Lounatmaa K, Haapaniemi T, Lehtimäki T, Laaksonen R, Karhunen PJ, Mikkelsson J Tags: Circulation Source Type: research

Effect of Bacterial Pneumonia on Lung Simian Immunodeficiency Virus (SIV) Replication in Alcohol Consuming SIV-Infected Rhesus Macaques.
CONCLUSIONS: This study indicates that chronic EtOH feeding results in enhanced local, but not systemic, SIV replication following pneumococcal pneumonia. Increased NF-κB activity in the setting of chronic EtOH ingestion may play a mechanistic role in this observation. PMID: 23414480 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - February 15, 2013 Category: Addiction Authors: Nelson S, Happel KI, Zhang P, Myers L, Dufour JP, Bagby GJ Tags: Alcohol Clin Exp Res Source Type: research

Winogradskyella pulchriflava sp. nov., isolated from marine sediment.
Abstract A taxonomic study was conducted on strain EM106T, isolated from a sediment sample of the East Sea, Republic of Korea. Comparative 16S rRNA gene sequence analyses showed that strain EM106T belongs to the family Flavobacteriaceae and is most closely related to Winogradskyella echinorum KMM 6211T and Winogradskyella ulvae KMM 6390T (97.8 and 97.3% 16S rRNA gene sequence similarities, respectively). The G+C content of the genomic DNA of strain EM106T was 33.3 mol%, and the major respiratory quinone was menaquinone-6. The polar lipids of EM106T were phosphatidylethanolamine and two unidentified aminolipids and ...
Source: International Journal of Systematic and Evolutionary Microbiology - February 15, 2013 Category: Microbiology Authors: Kim SJ, Choi YR, Park SJ, Kim JG, Shin KS, Roh DH, Rhee SK Tags: Int J Syst Evol Microbiol Source Type: research

Pustulibacterium marinum gen. nov., sp. nov., a novel member of the family Flavobacteriaceae isolated from the Bashi Channel.
Abstract A Gram-negative, non-spore-forming, gliding, non-translucent, colorless or yellow, aerobic, and elevated colony-forming strain, designated E403T, was isolated from the Bashi Channel and subjected to a polyphasic taxonomy study. Strain E403T can grow in the presence of 0.3-8% (w/v) NaCl, 16-43 °C and pH 6-9, and grew optimally at 28 °C, pH 8 in natural seawater medium. The respiratory quinones were MK-6 (93%) and MK-7 (7%). The major fatty acids were iso-C15:0 (26.13%), iso-C17:0 3-OH (20.15%), iso-C15:1 G (12.22%), summed feature 3 (C16:1ω7c/C16:1ω6c, 10.15%), iso-C15:0 3-OH (6.07%) and C16:0(5.32%). T...
Source: International Journal of Systematic and Evolutionary Microbiology - February 15, 2013 Category: Microbiology Authors: Wang G, Zhou D, Dai S, Tian X, Li J, Chen W, Xiang W, Li X Tags: Int J Syst Evol Microbiol Source Type: research

Notes from the Field: Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae Producing New Delhi Metallo-Beta-Lactamase - Denver, Colorado, 2012.
Abstract On August 16, 2012, the Colorado Department of Public Health and Environment was notified of two patients at an acute-care hospital in Denver with carbapenem-resistant Enterobacteriaceae (CRE), specifically Klebsiella pneumoniae (CRKP), isolated from respiratory specimens during July-August. Both isolates produced New Delhi metallo-beta-lactamase (NDM). A review of microbiology records identified a third patient with NDM-producing CRKP isolated from a respiratory specimen, admitted in May. Active surveillance cultures in September identified an additional five patients colonized with NDM-producing CRKP. An...
Source: MMWR Morb Mortal Wkl... - February 15, 2013 Category: Epidemiology Authors: Centers for Disease Control and Prevention (CDC) Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Obstructive Inflammatory Tracheal Pseudomembrane.
Abstract Pathologies acquired after the establishment of an artificial airway include stenosis, granulomas and the formation of pseudomembranes, to name a few. The most common form of presentation in adults is circumferential stenosis, which often requires therapeutic endoscopic measures to achieve resolution. This Case Report describes the case of an obstructive inflammatory tracheal pseudomembrane in the shape of a tracheal septum secondary to repeated intubations that was resolved with conservative treatment. The clinical presentation of this entity generally includes the appearance of respiratory infection and/...
Source: Archivos de Bronconeumologia - February 15, 2013 Category: Respiratory Medicine Authors: Crespo-Lessmann A, Torrego-Fernández A Tags: Arch Bronconeumol Source Type: research

Inhibition of Overactive TGF-beta Signaling by Prostacyclin Analogues in Pulmonary Arterial Hypertension (PAH).
This study demonstrates that this agent inhibits TGF-β1-induced SMAD-dependent and -independent signaling via a PKA dependent pathway by reducing the phosphorylation of SMADs 2 and 3 and p38MAPK proteins. Finally, in a monocrotaline (MCT)-induced rat model of PAH, which is associated with increased TGF-β signaling, this study confirms that treprostinil (TPS), a stable prostacyclin analogue, inhibits the TGF-β pathway by reducing SMAD3 phosphorylation. Taken together, these data suggest that prostacyclin analogues inhibit dysregulated TGF-β signaling in vitro and in vivo and reduce BMPR-II-mediated proliferation defect...
Source: Am J Respir Cell Mol... - February 15, 2013 Category: Respiratory Medicine Authors: Ogo T, Chowdhury HM, Yang J, Long L, Li X, Torres Cleuren YN, Morrell NW, Schermuly RT, Trembath RC, Nasim MT Tags: Am J Respir Cell Mol Biol Source Type: research

Innate Immune Response of Human Alveolar Type II Cells Infected with SARS-Coronavirus.
Conclusions: Cultivation of alveolar type II cells at an air-liquid interface provides primary cultures in which to study the pulmonary innate immune responses to infection with SARS-CoV and to explore possible therapeutic approaches to modulating their innate immune response. PMID: 23418343 [PubMed - as supplied by publisher]
Source: Am J Respir Cell Mol... - February 15, 2013 Category: Respiratory Medicine Authors: Qian Z, Travanty EA, Oko L, Edeen K, Berglund A, Wang J, Ito Y, Holmes KV, Mason R Tags: Am J Respir Cell Mol Biol Source Type: research

Spag17 is Essential for Motile Cilia Function and Neonatal Survival.
Abstract Primary ciliary dyskinesia (PCD), resulting from defects in cilia assembly or motility, is caused by mutations in a number of genes encoding axonemal proteins. PCD phenotypes are variable, and include recurrent respiratory tract infections, bronchiectasis, hydrocephaly, situs inversus and male infertility. We generated knockout mice for the Spag17 gene, which encodes a central pair (CP) protein present in the axonemes of cells with "9+2" motile cilia or flagella. Targeting of Spag17 resulted in a severe phenotype characterized by immotile nasal and tracheal cilia, reduced clearance of nasal mucus, profound...
Source: Am J Respir Cell Mol... - February 15, 2013 Category: Respiratory Medicine Authors: Teves ME, Zhang Z, Costanzo RM, Henderson SC, Corwin FD, Zweit J, Sundaresan G, Subler M, Salloum FN, Rubin BK, Strauss JF Tags: Am J Respir Cell Mol Biol Source Type: research

The return of the minimum clinically important difference for 6-minute-walk distance in chronic obstructive pulmonary disease.
PMID: 23418323 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Holland AE, Nici L Tags: Am J Respir Crit Care Med Source Type: research

The promise of epigenetic therapies in treatment of idiopathic pulmonary fibrosis.
PMID: 23418324 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Rosas IO, Yang IV Tags: Am J Respir Crit Care Med Source Type: research

Mitochondria in hypoxic pulmonary vasoconstriction: potential importance of compartmentalized reactive oxygen species signaling.
PMID: 23418325 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Gillespie MN, Al-Mehdi AB, McMurtry IF Tags: Am J Respir Crit Care Med Source Type: research

Central sleep apnea: effects on stroke volume in heart failure.
PMID: 23418326 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Cao M, Guilleminault C, Lin C Tags: Am J Respir Crit Care Med Source Type: research

It takes more than cells to make a good lung.
PMID: 23418327 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Weibel ER Tags: Am J Respir Crit Care Med Source Type: research

24/7 intensivist coverage, macrolides in acute lung injury, and roflumilast.
PMID: 23418328 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Amin EN, McCann ET, Mieczkowski BP Tags: Am J Respir Crit Care Med Source Type: research

The vanishing lungs!
PMID: 23418329 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Mohammad K, Siddiqui MF, Badireddi S Tags: Am J Respir Crit Care Med Source Type: research

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration versus Cervical Mediastinoscopy: Case Selection Is Needed to Maintain Cost Benefits.
PMID: 23418330 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Agarwal S, Ahmad N Tags: Am J Respir Crit Care Med Source Type: research

Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Diagnosing and Subtyping Lung Cancer: Is It Required in All Patients?
PMID: 23418331 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Maturu VN, Agarwal R Tags: Am J Respir Crit Care Med Source Type: research

Wanted: lung cancer pathologists.
PMID: 23418332 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Rossi G Tags: Am J Respir Crit Care Med Source Type: research

Bronchobiliary fistula and lithoptysis after endoscopic retrograde cholangiopancreatography and liver biopsy in a patient with paroxysmal nocturnal hemoglobinuria.
PMID: 23418333 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Harnoss JM, Yung R, Brodsky RA, Hruban RH, Boitnott JK, Murphy DJ, Yang SC, Choti MA Tags: Am J Respir Crit Care Med Source Type: research

Type V Collagen-induced Tolerance Prevents Airway Hyperresponsiveness.
PMID: 23418334 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Lott JM, Sehra S, Mehrotra P, Mickler EA, Fisher AJ, Zhang W, Presson RG, Busk MF, Goenka S, Gunst SJ, Kaplan MH, Wilkes DS, Wenzel SE Tags: Am J Respir Crit Care Med Source Type: research

Unexpected bronchial anatomy lesson.
PMID: 23418335 [PubMed - in process]
Source: American Journal of Respiratory and Critical Care Medicine - February 15, 2013 Category: Respiratory Medicine Authors: Ribeiro Neto ML, Hoffman S, Almeida FA Tags: Am J Respir Crit Care Med Source Type: research

Relationship between Bradykinin-induced relaxation and endogenous epoxy-eicosanoid synthesis in human bronchi.
Abstract Epoxy-eicosanoids (EETs) are produced by CYP 450 epoxygenase; however it is not yet known what triggers their endogenous production in epithelial cells. The relaxing effects of Bradykinin are known to be related to endogenous production of epithelial-derived hyperpolarizing factors (EpDHF). Because of their effects on membrane potential, EETs have been reported to be EpDHF candidates (9). Thus, we hypothesized that Bradykinin may stimulate endogenous EET production in human bronchi. To test this hypothesis, the relaxing and hyperpolarizing effects of Bradykinin (BK) and 14,15-EET were quantified on human b...
Source: Am J Physiol Lung Ce... - February 15, 2013 Category: Respiratory Medicine Authors: Tabet Y, Sirois M, Sirois C, Rizcallah E, Rousseau E Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research