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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Endozoicomonas atrinae sp. nov., a bacterium isolated from the intestine of a comb pen shell Atrina pectinata.
Abstract A novel strain, designated strain WP70T, was isolated from the gut of a comb pen shell (Atrina pectinata) collected from the southern sea of Yeosu in Korea. The isolate was Gram-stain-negative, aerobic, non-motile and rod-shaped. Phylogenetic analyses based on 16S rRNA gene sequences indicated that strain WP70T belongs to the genus Endozoicomonas. The highest level of sequence similarity (98.4%) was shared with Endozoicomonas elysicola. Optimal growth occurred in 2 % (w/v) NaCl at 30 °C and at pH 7. The major cellular fatty acids were summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), summed feature 8 (C18:...
Source: International Journal of Systematic and Evolutionary Microbiology - April 14, 2014 Category: Microbiology Authors: Hyun DW, Shin NR, Kim MS, Oh SJ, Kim PS, Whon TW, Bae JW Tags: Int J Syst Evol Microbiol Source Type: research

[ALS treatment: State of the art in 2014 and perspectives.]
Abstract Progresses in the multidisciplinary care, particularly in the nutritional and respiratory management, allowed improving the quality of life and survival of ALS patients. Non-invasive ventilation is initially performed overnight but with the progression of diaphragmatic weakness, a continuous ventilatory support is often needed. Advances directives regarding end-of-life issues are important to respect patient's wishes regarding the choice of invasive ventilation with tracheostomy. Riluzole is the only neuroprotective drug that has demonstrated a significant but modest effect on survival and is well tolerate...
Source: Presse Medicale - April 14, 2014 Category: Journals (General) Authors: Pradat PF, Dupuis L Tags: Presse Med Source Type: research

Predictors of hippocampal atrophy in critically ill patients
ConclusionsThis analysis suggests that high levels of procalcitonin and interleukin‐6 in the blood serum of critically ill patients are associated with a high likelihood of hippocampal atrophy irrespective of the severity of disease measured by ICU scoring systems and other inflammatory parameters. (Source: European Journal of Neurology)
Source: European Journal of Neurology - April 13, 2014 Category: Neurology Authors: A. Lindlau, C. N. Widmann, C. Putensen, F. Jessen, A. Semmler, M. T. Heneka Tags: Short Communication Source Type: research

Respir Care; +104 new citations
104 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Respir Care These pubmed results were generated on 2014/04/13PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Respiratory Care)
Source: Respiratory Care - April 13, 2014 Category: Respiratory Medicine Tags: Report Source Type: research

Sex Differences in Remifentanil Requirements for Preventing Cough during Anesthetic Emergence.
CONCLUSION: When using remifentanil TCI for cough prevention during anesthetic emergence, patient sex should be a considered for appropriate dosing. PMID: 24719152 [PubMed - in process] (Source: Yonsei Medical Journal)
Source: Yonsei Medical Journal - April 13, 2014 Category: Universities & Medical Training Authors: Soh S, Park WK, Kang SW, Lee BR, Lee JR Tags: Yonsei Med J Source Type: research

Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic function
This study provides rationale for enhancement of current cancer prevention models and current therapies by combining them with dietary sources, like DHA. © 2014 Wiley Periodicals, Inc. (Source: Molecular Carcinogenesis)
Source: Molecular Carcinogenesis - April 12, 2014 Category: Molecular Biology Authors: Michael Mouradian, Keith D. Kikawa, Brian P. Dranka, Steven M. Komas, Balaraman Kalyanaraman, Ronald S. Pardini Tags: Research Article Source Type: research

Evaluating national guidelines for the prophylactic treatment of respiratory syncytial virus in children with congenital heart disease
ConclusionHaving CHD increased the rate and estimated relative risk of being hospitalised for RSV. The guidelines were not followed for about half of the children born before an RSV season, and a quarter of the children born during a season, and need updating.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - April 12, 2014 Category: Pediatrics Authors: Elin Granbom, Eva Fernlund, Jan Sunnegårdh, Bo Lundell, Estelle Naumburg Tags: Regular Article Source Type: research

Non-neurological, steroid-related adverse events in very low birth weight infants: a prospective audit.
CONCLUSIONS: The use of steroids was significantly associated with severe short-term adverse events - most importantly hypertrophic cardiomyopathy and thrombus formation. These complications must be taken into consideration when administering steroids to VLBW infants. PMID: 24706463 [PubMed - in process] (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 12, 2014 Category: Journals (General) Authors: Röhr SB, Sauer H, Gottschling S, Abdul-Khaliq H, Gortner L, Nunold H, Gräber S, Meyer S Tags: Swiss Med Wkly Source Type: research

Respiratory activity in the 6-hydroxydopamine model of Parkinson's disease in the rat.
Abstract Respiratory disturbances accompany Parkinson's disease. Weakness of the respiratory muscles or lowering of central respiratory drive might be responsible for respiratory disability. Striatal injection of 6-hydroxydopamine (6-OHDA) simulates motor symptoms of Parkinson's disease in the rat. Present study investigated whether unilateral infusion of 6-OHDA into the striatum may evoke respiratory disorders and therefore be a model for the study of the respiratory aspects of Parkinson's disease. Two weeks after the infusion the animals were anesthetized, vagotomized, paralyzed and artificially ventilated. Neura...
Source: Acta Neurobiologiae Experimentalis - April 12, 2014 Category: Neurology Authors: Budzinska K, Andrzejewski K Tags: Acta Neurobiol Exp (Wars) Source Type: research

Chromogenic in situ hybridisation (CISH) is a powerful method to detect ALK-positive non-small cell lung carcinomas
Conclusions CISH is a very reliable, convenient and inexpensive method to detect ALK-positive NSCLC. CISH success rate is comparably high as with qPCR, and it detects all ALK break apart events in a single assay. It is of special value when RNA quality is poor, or when small biopsies with a very limited amount of tumour cells have to be analysed. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - April 12, 2014 Category: Pathology Authors: Wagner, F., Streubel, A., Roth, A., Stephan-Falkenau, S., Mairinger, T. Tags: Immunology (including allergy), Lung cancer (oncology), Lung cancer (respiratory medicine), Clinical diagnostic tests Original article Source Type: research

Tobacco industry argues domestic trademark laws and international treaties preclude cigarette health warning labels, despite consistent legal advice that the argument is invalid
Conclusions Governments should not be intimidated by tobacco company threats and unsubstantiated claims, and carefully craft HWL laws to withstand the inevitable tobacco industry lawsuits with the knowledge that the companies’ own lawyers as well as authoritative bodies have told the companies that the rights they claim do not exist. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Crosbie, E., Glantz, S. A. Tags: Online article Source Type: research

Creating demand for foreign brands in a 'home run' market: tobacco company tactics in South Korea following market liberalisation
Conclusions Governments engaging in trade negotiations that may lead to the opening of domestic tobacco markets need a fuller understanding of previous industry activities for expanding into emerging markets as well as how the domestic industry can change accordingly. To protect public health, the adoption of comprehensive tobacco control measures, guided by WHO Framework Convention on Tobacco Control, are needed as part of such negotiations. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Lee, S., Lee, K., Holden, C. Tags: Online article Source Type: research

Overcautious FDA has lost its way
Five years after the passage of the Family Smoking Prevention and Tobacco Control Act, little progress has been made in the effort to regulate the US tobacco industry and advance the public health goals of tobacco control. Legal challenges by the tobacco industry, and evidence of political interference from the White House have resulted in the US Food and Drug Administration's (FDA) overcautious approach toward advancing a meaningful regulatory agenda. While the White House bears final responsibility, it is incumbent upon the FDA and its Center for Tobacco Products to become more aggressive and seize the extraordinary oppo...
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Gottlieb, M. Tags: Editorial Source Type: research

Worldwide news and comment
Indonesia: Inter-tabac Asia cancelled Following sustained international pressure and a Change.org petition that gathered over 12 000 signatures, the tobacco trade fair Inter-tabac Asia 2014 was cancelled just days before it was due to be held in Bali on 27 and 28 February. The trade fair had been billed as an opportunity to access the "booming growth market of Asia for companies in the tobacco industry and expand recognition in Asia’s growing markets." In an announcement on the event website, the German organiser Messe Westfalenhallen Dortmund GmbH, a wholly owned company of the city of Dortmund, Germany, advise...
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Tags: TC News analysis Source Type: research

Tobacco smoke pollution in the 'non-smoking' sections of selected popular restaurants in Pretoria, South Africa
Exposure to second-hand tobacco smoke (SHS) has been associated with several adverse health effects including increased risk of lung cancer, heart disease and also asthma in children.1 Hence, the WHO's Framework Convention on Tobacco Control (FCTC) obligates parties to the Convention, to implement measures to protect all people from the exposure to SHS.2 Even prior to signing the WHO FCTC in 2005, the South African government in 2001 implemented a regulation to restrict smoking in public places, including restaurants.3 However, the current regulation in South Africa allows for a designated ‘smoking area’. It is...
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Ayo-Yusuf, O. A. Tags: Research letter Source Type: research

The Lighter Side
(Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Tags: PostScript Source Type: research

Consequences of clean indoor air exemptions in Oregon: the hookah story
The WHO Framework Convention on Tobacco Control has stimulated the passage of comprehensive clean indoor air laws throughout the world.1 Although WHO guidelines stress the importance of universal protection from secondhand smoke in such laws,2 many states in the USA exempt certain locations such as tobacco retail establishments and tobacco bars/cigar lounges.3 4 Tobacco waterpipe (ie, hookah) establishments are often exempt from these laws, are growing in popularity and may change social norms regarding hookah use.3 4 Indeed, hookah use among young people in the USA appears to be increasing,5 as it is elsewhere,6 and the l...
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Maher, J. E., Morris, D. S., Girard, K. E., Pizacani, B. A. Tags: Research letter Source Type: research

Dependence measures for non-cigarette tobacco products within the context of the global epidemic: a systematic review
Conclusions For purposes of global surveillance of tobacco dependence, there is a compelling need for validated measures to apply universally across social contexts and a multitude of tobacco products. Alternatively, effective tobacco control interventions require validated dependence measures that integrate specific behavioural elements and social context of product use. While different measures of dependence are required to fulfil each of these goals, both have value in addressing the global tobacco epidemic. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: De Leon, E., Smith, K. C., Cohen, J. E. Tags: Editor's choice Review Source Type: research

The Lighter Side
(Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Tags: PostScript Source Type: research

Do smoke-free policies in work and public places increase smoking in private venues?
Conclusions Smoke-free legislation in workplaces and public places is not correlated with increased smoking prevalence in private venues (houses and cars) at an ecological level. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Martinez-Sanchez, J. M., Blanch, C., Fu, M., Gallus, S., La Vecchia, C., Fernandez, E. Tags: Brief report Source Type: research

Adolescent and adult perceptions of traditional and novel smokeless tobacco products and packaging in rural Ohio
Conclusions Packaging has a significant role in shaping perceptions of ST and consumer behaviour. Regulation of product packaging such as shape, size and images should be part of comprehensive tobacco control. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Liu, S. T., Nemeth, J. M., Klein, E. G., Ferketich, A. K., Kwan, M.-P., Wewers, M. E. Tags: Research paper Source Type: research

The natural history of antismoking advertising recall: the influence of broadcasting parameters, emotional intensity and executional features
Conclusions In order to achieve sufficient levels of population recall of antismoking campaigns, advertisements need to be broadcast at adequate levels in relatively frequent cycles. Advertisements with highly emotional content may offer the most efficient means by which to increase population recall. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Dunlop, S. M., Perez, D., Cotter, T. Tags: Research paper Source Type: research

Cost effectiveness of full coverage of the medical management of smoking cessation in France
Conclusions Compared to other health measures in primary and secondary prevention of cardiovascular disease already covered by SHI, full coverage of smoking cessation is the most cost-effective approach. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Chevreul, K., Cadier, B., Durand-Zaleski, I., Chan, E., Thomas, D. Tags: Research paper Source Type: research

Growth in Tobacco Control publications by authors from low- and middle-income countries
Conclusions Efforts to expand research by LMIC authors and about LMIC issues have begun to bear fruit, with a recent substantial increase. Still, the centrality of LMICs in the global tobacco pandemic implies that this progress only begins to address the enormous need. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Warner, K. E., Tam, J., Koltun, S. M. Tags: Research paper Source Type: research

Smoking while driving and public support for car smoking bans in Italy
Conclusions Despite the high percentage of smokers who smoke in private vehicles, the majority of the Italian population (including smokers) support the introduction of a smoking ban in cars, particularly in cars carrying children. Smoke-free laws should therefore be extended to private vehicles, particularly if they are carrying children. Moreover, warning labels on cigarette packages should include information on the increased risk of accidents when smoking while driving. Mass media campaigns should also consider targeting this topic. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Martinez-Sanchez, J. M., Gallus, S., Lugo, A., Fernandez, E., Invernizzi, G., Colombo, P., Pacifici, R., La Vecchia, C. Tags: Research paper Source Type: research

Tobacco advertising/promotions and adolescents' smoking risk in Northern Africa
Conclusions Tobacco advertising/promotion exposure was highly prevalent and associated with adolescents' smoking risk in these countries. The comprehensiveness and enforcement of advertising/promotion bans needs to be enhanced. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Madkour, A. S., Ledford, E. C., Andersen, L., Johnson, C. C. Tags: Research paper Source Type: research

Association of cigarette smoking with skin colour in Japanese women
Conclusions These data suggest that smoking is associated with a darker skin colour. If our findings are confirmed by further studies, they could be used in antismoking campaigns or by smoking cessation services. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Tamai, Y., Tsuji, M., Wada, K., Nakamura, K., Hayashi, M., Takeda, N., Yasuda, K., Nagata, C. Tags: Research paper Source Type: research

Tobacco imagery on prime time UK television
Conclusions Television programming is a source of significant exposure of youth to tobacco imagery, before and after the watershed. Tobacco branding is particularly common in Coronation Street, a soap opera popular among youth audiences. More stringent controls on tobacco in prime time television therefore have the potential to reduce the uptake of youth smoking in the UK. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Lyons, A., McNeill, A., Britton, J. Tags: Open access Research paper Source Type: research

Thirdhand smoke and exposure in California hotels: non-smoking rooms fail to protect non-smoking hotel guests from tobacco smoke exposure
Conclusions Partial smoking bans in hotels do not protect non-smoking guests from exposure to tobacco smoke and tobacco-specific carcinogens. Non-smokers are advised to stay in hotels with complete smoking bans. Existing policies exempting hotels from complete smoking bans are ineffective. (Source: Tobacco Control)
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Matt, G. E., Quintana, P. J. E., Fortmann, A. L., Zakarian, J. M., Galaviz, V. E., Chatfield, D. A., Hoh, E., Hovell, M. F., Winston, C. Tags: Research paper Source Type: research

The importance of cigarette packaging in a 'dark' market: the 'Silk Cut' experience
In a growing number of countries tobacco companies are severely restricted in how they can legally market their products. In these ‘dark’ markets the role of packaging as a promotional and communications tool becomes more pronounced. How packaging is used for the most expensive cigarette brands in dark markets has received limited attention however, even though these ‘premium’ cigarette brands significantly impact upon the profitability of tobacco companies. We outline, using retail trade press journals, how packaging was used for premium brand ‘Silk Cut’ in the UK from 2004 to 2011, fol...
Source: Tobacco Control - April 12, 2014 Category: Respiratory Medicine Authors: Moodie, C., Angus, K., Ford, A. Tags: Special communication Source Type: research

Highlights from this issue
Don't miss this American Pie This issue coinciding with the ATS meeting in San Diego has a North American theme. In addition to a number of strong research papers, there is a HOT off the breath by Detterbeck (see page 406) on minimising VOMITing in cancer management (see Airwaves passim, or previous issues for the classically challenged) and two great reviews on the genomic origins of asthma from the Channing laboratory (see page 481), and an –omics perspective on sleep disordered breathing in children (see page 474). This last, from a future ATS president, is a really hot topic – snoring is no joke but a clear...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Airwaves Source Type: research

HRCT-defined emphysema is not COPD to be treated with inhalers
The COPDGene Study1 is providing important new information about the natural history of several chronic obstructive pulmonary disease (COPD) phenotypes.2 This multicentre study enrolled a large number of current and former smokers with a wide range of spirometry results (from normal to very severe airflow obstruction), carefully characterised them during their baseline examination, and has been following them for several important outcome measures. The key phenotypes include (1) chronic airflow obstruction (CAO) defined by a low post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC), (2) hig...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Enright, P. Tags: Editorial Source Type: research

Measuring diaphragm shortening using ultrasonography to predict extubation success
It is estimated that approximately 800 000 US patients annually require mechanical ventilation to treat acute respiratory failure due to medical disorders, trauma or the postoperative period.1 The use of mechanical ventilation is projected to increase significantly in the next few decades due to the impact of aging baby bloomers requiring more critical care resources.2 Although life-saving, the prolonged use of mechanical ventilation is associated with significant complications such as nosocomial pneumonia, barotrauma, patient discomfort, airway complications and respiratory muscle atrophy and accounts for a substanti...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Criner, G. J. Tags: Editorial Source Type: research

Will SUMMIT reach the peak in COPD?
Introduction The Study to Understand Mortality and Morbidity in COPD (SUMMIT) is a randomised controlled trial conducted in patients with COPD and comorbid cardiovascular disease, designed to assess the ‘impact of Fluticasone Furoate/Vilanterol combination (FF/VI) and its individual components on the survival of patients with moderate COPD and either a history of CVD or at increased risk for CVD’.1 Fluticasone furoate is an inhaled corticosteroid (ICS) and vilanterol is a long-acting β-agonist (LABA). The trial is enrolling 16 000 such patients with moderate COPD randomly assigned to once daily treatm...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Suissa, S. Tags: Epidemiologic studies, Drugs: respiratory system HOT off the breath Source Type: research

Overdiagnosis during lung cancer screening: is it an overemphasised, underappreciated, or tangential issue?
The issue of overdiagnosis is frequently raised in the context of lung cancer screening. Two recent papers draw attention to this matter: one by Patz et al,1 which estimates the incidence of overdiagnosis in the experience of the National Lung Screening Trial, and the US Preventative Services Task Force report that recommends screening in an organised programme for individuals at an elevated risk of developing lung cancer.2Make everything as simple as possible, but not simpler (Albert Einstein) Overdiagnosis—what is it exactly? There are many definitions. In the Patz paper these are excess cancers identified in the s...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Detterbeck, F. C. Tags: Lung neoplasms, Epidemiologic studies, Lung cancer (oncology), Screening (oncology), Child health, Infant health, Lung cancer (respiratory medicine), Screening (epidemiology), Screening (public health) HOT off the breath Source Type: research

Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction
Conclusions Compared with the fixed ratio, the use of LLN fails to identify a number of patients with significant pulmonary pathology and respiratory morbidity. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Bhatt, S. P., Sieren, J. C., Dransfield, M. T., Washko, G. R., Newell, J. D., Stinson, D. S., Zamba, G. K. D., Hoffman, E. A., for the COPDGene Investigators Tags: Epidemiologic studies, Health education, Smoking, Tobacco use Chronic obstructive pulmonary disease Source Type: research

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema
Background There is notable heterogeneity in the clinical presentation of patients with COPD. To characterise this heterogeneity, we sought to identify subgroups of smokers by applying cluster analysis to data from the COPDGene study. Methods We applied a clustering method, k-means, to data from 10 192 smokers in the COPDGene study. After splitting the sample into a training and validation set, we evaluated three sets of input features across a range of k (user-specified number of clusters). Stable solutions were tested for association with four COPD-related measures and five genetic variants previously associated wi...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Castaldi, P. J., Dy, J., Ross, J., Chang, Y., Washko, G. R., Curran-Everett, D., Williams, A., Lynch, D. A., Make, B. J., Crapo, J. D., Bowler, R. P., Regan, E. A., Hokanson, J. E., Kinney, G. L., Han, M. K., Soler, X., Ramsdell, J. W., Barr, R. G., Forem Tags: Health education, Smoking, Tobacco use Chronic obstructive pulmonary disease Source Type: research

Measuring respiratory symptoms in clinical trials of COPD: reliability and validity of a daily diary
Conclusions Results suggest the RS-Total is a reliable and valid instrument for evaluating respiratory symptom severity in stable COPD. Further study of sensitivity to change is warranted. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Leidy, N. K., Sexton, C. C., Jones, P. W., Notte, S. M., Monz, B. U., Nelsen, L., Goldman, M., Murray, L. T., Sethi, S. Tags: Clinical trials (epidemiology), Open access, TB and other respiratory infections, Bronchitis, Health education, Smoking, Tobacco use Chronic obstructive pulmonary disease Source Type: research

Diaphragm ultrasound as a predictor of successful extubation from mechanical ventilation
Conclusions Ultrasound measures of diaphragm thickening in the zone of apposition may be useful to predict extubation success or failure during SB or PS trials. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: DiNino, E., Gartman, E. J., Sethi, J. M., McCool, F. D. Tags: Editor's choice, Mechanical ventilation, Airway biology, Mechanical ventilation, Radiology (diagnostics) Critical care Source Type: research

Connective tissue disease related interstitial lung diseases and idiopathic pulmonary fibrosis: provisional core sets of domains and instruments for use in clinical trials
Conclusion Identification of consensus preliminary domains and instruments to measure them was attained and is a major advance anticipated to facilitate multicentre RCTs in the field. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Saketkoo, L. A., Mittoo, S., Huscher, D., Khanna, D., Dellaripa, P. F., Distler, O., Flaherty, K. R., Frankel, S., Oddis, C. V., Denton, C. P., Fischer, A., Kowal-Bielecka, O. M., LeSage, D., Merkel, P. A., Phillips, K., Pittrow, D., Swigris, J., Antoniou Tags: Open access, Interstitial lung disease Source Type: research

Development and validation of a lung transplant-specific disability questionnaire
Conclusions The LT-VLA is a short, easy to administer, valid and responsive disease-specific PCO instrument that may be useful in clinical and research applications for lung transplantation. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Singer, J. P., Blanc, P. D., Dean, Y. M., Hays, S., Leard, L., Kukreja, J., Golden, J., Katz, P. P. Tags: Epidemiologic studies, Airway biology, Lung function, Cardiothoracic surgery, Transplantation Lung transplantation Source Type: research

DNA copy number aberrations in endobronchial lesions: a validated predictor for cancer
In conclusion, CNAs prove to be a highly accurate biomarker for assessing the progression risk of endobronchial squamous metaplastic and dysplastic lesions. This classifier could assist in selecting subjects with endobronchial lesions who might benefit from more aggressive therapeutic intervention or surveillance. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: van Boerdonk, R. A. A., Daniels, J. M. A., Snijders, P. J. F., Grunberg, K., Thunnissen, E., van de Wiel, M. A., Ylstra, B., Postmus, P. E., Meijer, C. J. L. M., Meijer, G. A., Smit, E. F., Sutedja, T. G., Heideman, D. A. M. Tags: Cardiothoracic surgery Lung cancer Source Type: research

High treatment success in children treated for multidrug-resistant tuberculosis: an observational cohort study
We describe the presentation, treatment and outcome in children treated for severe and non-severe MDR-TB in Cape Town, South Africa. Methods We conducted an observational cohort study of all children (<15 years) treated for MDR-TB if routinely initiated on treatment between January 2009 and December 2010. Treatment was based on local standard of care, based on international guidelines. Data were collected through family interviews and folder review. Standardised definitions were used for diagnosis, severity of disease, adverse events and outcome. Results Of 149 children started on MDR-TB treatment, the median age...
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Seddon, J. A., Hesseling, A. C., Godfrey-Faussett, P., Schaaf, H. S. Tags: Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Child health Tuberculosis Source Type: research

Chronic obstructive pulmonary disease mortality and prevalence: the associations with smoking and poverty--a BOLD analysis
Conclusions Smoking remains the single most important cause of obstruction but a high prevalence of restriction associated with poverty could explain the high ‘COPD’ mortality in poor countries. (Source: Thorax)
Source: Thorax - April 12, 2014 Category: Respiratory Medicine Authors: Burney, P., Jithoo, A., Kato, B., Janson, C., Mannino, D., Nizankowska-Mogilnicka, E., Studnicka, M., Tan, W., Bateman, E., Kocabas, A., Vollmer, W. M., Gislason, T., Marks, G., Koul, P. A., Harrabi, I., Gnatiuc, L., Buist, S., for the Burden of Obstructi Tags: Epidemiologic studies, Open access, Health education, Smoking, Tobacco use Respiratory epidemiology Source Type: research