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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 5.

Computerized auditory cognitive training to improve cognition and functional outcomes in patients with heart failure: Results of a pilot study
Conclusion Results indicated ACT is feasible among persons with HF. Despite a small sample size, ACT showed potential for improved speed of processing and working memory and improved functional outcomes, and warrants further exploration. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - January 26, 2015 Category: Respiratory Medicine Source Type: research

Insomnia is associated with quality of life impairment in medical-surgical intensive care unit survivors
Conclusions Insomnia is common among ICU survivors. Post-ICU insomnia is significantly associated with mental HRQOL and could identify ICU survivors who may benefit from further psychiatric evaluation. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - January 26, 2015 Category: Respiratory Medicine Source Type: research

The relationship between pain, fatigue, depression and functional performance in stable heart failure
Conclusions Pain, fatigue and depression were associated with decreased functional performance in stable HF. Symptom management interventions are needed in HF. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - January 26, 2015 Category: Respiratory Medicine Source Type: research

The present of presence
Publication date: Available online 5 January 2015 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Juanita (Nita) Reigle (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - January 26, 2015 Category: Respiratory Medicine Source Type: research

High Chlamydia burden promotes TNF‐dependent reactive arthritis in SKG mice
Conclusion: In the susceptible SKG strain, Chlamydia‐induced reactive arthritis develops as a result of deficient intracellular pathogen control, with antigen‐specific TNF production upon dissemination of antigen, and TNF‐dependent inflammatory disease. This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 26, 2015 Category: Rheumatology Authors: Athan C Baillet, Linda Rehaume, Helen Benham, Connor P O'Meara, Charles W Armitage, Roland Ruscher, Geraldine Brizard, Marina CG Harvie, Jared Velasco, Phillip Hansbro, John V. Forrester, Mariapia Degli‐Esposti, Kenneth W Beagley, Ranjeny Thomas Tags: Full Length Source Type: research

Novel personalized therapies for cystic fibrosis: treating the basic defect in all patients
Abstract Cystic fibrosis (CF) is the most common genetic life‐shortening condition in Caucasians. Despite being a multi‐organ disease, CF is classically diagnosed by symptoms of acute/chronic respiratory disease, with persistent pulmonary infections and mucus plugging of the airways and failure to thrive. These multiple symptoms originate from dysfunction of the CF transmembrane conductance regulator (CFTR) protein, a channel that mediates anion transport across epithelia. Indeed, establishment of a definite CF diagnosis requires proof of CFTR dysfunction, commonly through the so‐called sweat Cl− test. Many drug th...
Source: Journal of Internal Medicine - January 26, 2015 Category: Internal Medicine Authors: M. D. Amaral Tags: Review Source Type: research

Industry opinion on the likely routes of introduction of highly pathogenic porcine reproductive and respiratory syndrome into Australia from south‐east Asia
ConclusionThis study demonstrated that the expert elicitation technique was useful in rapidly assessing opinion from a large group of pig industry experts regarding exposure of pigs in Australia to HP‐PRRS virus. The results of this survey were used to direct a risk assessment of an incursion of HP‐PRRS. (Source: Australian Veterinary Journal)
Source: Australian Veterinary Journal - January 26, 2015 Category: Veterinary Research Authors: VJ Brookes, M Hernández‐Jover, P Holyoake, MP Ward Tags: PRODUCTION ANIMALS Source Type: research

Homozygous R1820W mutation results in recessive myosin storage myopathy: scapuloperoneal and respiratory weakness with dilated cardiomyopathy
• Our research family with MSM is the second family with recessive MYH7 mutation.• We identified a homozygous missense mutation in MYH7 exon 37.• One patient has an unusual combination of MSM and dilated cardiomyopathy.• The study emphasizes the genetic and clinical heterogeneity with MYH7 mutation. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - January 26, 2015 Category: Neurology Authors: Nur Yüceyar, Özgecan Ayhan, Hatice Karasoy, Aslıhan Tolun Tags: Case report Source Type: research

Understanding health beliefs and behaviour in workers with suspected occupational asthma
This study aimed to explore reasons behind such delays. A purposive sample of 20 individuals diagnosed with, or under investigation for, occupational asthma (median age=52; 70% male; 80% white British) undertook a single semi-structured interview. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 26, 2015 Category: Respiratory Medicine Authors: Gareth I. Walters, Andy Soundy, Alastair S. Robertson, P.Sherwood Burge, Jon G. Ayres Source Type: research

Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease
Acrolein, a highly reactive unsaturated aldehyde, is a ubiquitous environmental pollutant and its potential as a serious environmental health threat is beginning to be recognized. Humans are exposed to acrolein per oral (food and water), respiratory (cigarette smoke, automobile exhaust, and biocide use) and dermal routes, in addition to endogenous generation (metabolism and lipid peroxidation). Acrolein has been suggested to play a role in several disease states including spinal cord injury, multiple sclerosis, Alzheimer’s disease, cardiovascular disease, diabetes mellitus, and neuro-, hepato-, and nephro-toxicity. O...
Source: Toxicological Sciences - January 26, 2015 Category: Toxicology Authors: Moghe, A., Ghare, S., Lamoreau, B., Mohammad, M., Barve, S., McClain, C., Joshi-Barve, S. Tags: Review: Mechanism of Acrolein Toxicity Source Type: research

Biological Dose Response to PM2.5: Effect of Particle Extraction Method on Platelet and Lung Responses
Particulate matter (PM) exposure contributes to respiratory diseases and cardiopulmonary mortality. PM toxicity is related to sources and composition, such as abundance of polycyclic aromatic hydrocarbons (PAHs). We exposed adult male BALB/c mice, via oropharyngeal aspiration, to a range of doses of PM2.5 collected during the winter in downtown Sacramento near a major freeway interchange (SacPM). Two preparation methods (spin-down and multi-solvent extraction) were tested to remove particles from collection filters. Three doses were analyzed 24 h after treatment for (1) leukocytes and total protein in bronchoalveolar lavag...
Source: Toxicological Sciences - January 26, 2015 Category: Toxicology Authors: Van Winkle, L. S., Bein, K., Anderson, D., Pinkerton, K. E., Tablin, F., Wilson, D., Wexler, A. S. Tags: Fine Particular Matter Extraction and Lung Responses Source Type: research

Does Respiratory Muscle Training Improve Cough Flow in Acute Stroke? Pilot Randomized Controlled Trial [Clinical Sciences]
Conclusions— Respiratory muscle function and cough flow improve with time after acute stroke. Additional inspiratory or expiratory respiratory muscle training does not augment or expedite this improvement. Clinical Trial Registration— URL: http://www.controlled-trials.com. Unique identifier: ISRCTN40298220. (Source: Stroke)
Source: Stroke - January 26, 2015 Category: Neurology Authors: Kulnik, S. T., Birring, S. S., Moxham, J., Rafferty, G. F., Kalra, L. Tags: Rehabilitation, Stroke, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Bactericidal Activity of Pyrazinamide and Clofazimine Alone and in Combinations with Pretomanid and Bedaquiline.
Abstract Rationale New regimens to shorten tuberculosis treatment and manage drug-resistant and human immunodeficiency virus infected tuberculosis patients are urgently needed. Experimental and clinical evidence suggests that the new drugs bedaquiline (B) and pretomanid (Pa), combined with an existing drug, pyrazinamide (Z), and a repurposed drug, clofazimine (C), may assist treatment shortening of both drug-susceptible and drug-resistant tuberculosis. Objective To evaluate the 14-day bactericidal activity of C and Z in monotherapy and in combinations with Pa and B. Methods Groups of 15 treatment-naïve, sputum sme...
Source: American Journal of Respiratory and Critical Care Medicine - January 26, 2015 Category: Respiratory Medicine Authors: Diacon AH, Dawson R, von Groote-Bidlingmaier F, Symons G, Venter A, Donald PR, van Niekerk C, Everitt D, Hutchings J, Burger DA, Schall R, Mendel CM Tags: Am J Respir Crit Care Med Source Type: research

Optimizing the Detection of Recent Tuberculosis Infection in Children in a High TB-HIV Burden Setting.
Conclusions: Where resources allow, use of interferon-gamma release assays should be considered in young, recently exposed, and HIV-infected children since they may offer advantages compared to the tuberculin skin test for identifying tuberculosis infection, and improve targeted, cost-effective delivery of preventive therapy. Affordable tests of infection could dramatically impact global tuberculosis control. PMID: 25622087 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 26, 2015 Category: Respiratory Medicine Authors: Mandalakas AM, Kirchner HL, Walzl G, Gie RP, Schaaf HS, Cotton MF, Grewal HM, Hesseling AC Tags: Am J Respir Crit Care Med Source Type: research

Nonsteroidal Anti-Inflammatory Drug Use and Endurance During Running in Male Long-Distance Runners.
Conclusions :  Ibuprofen did not reduce the effect of muscle damage and pain on performance. Prophylactic use of nonsteroidal anti-inflammatory drugs did not have an ergogenic effect on running performance after exercise-induced muscle damage in male long-distance runners. PMID: 25622243 [PubMed - as supplied by publisher] (Source: J Athl Train)
Source: J Athl Train - January 26, 2015 Category: Sports Medicine Authors: Da Silva E, Pinto RS, Cadore EL, Kruel LF Tags: J Athl Train Source Type: research

The role of transbronchial cryobiopsy and surgical lung biopsy in the diagnostic.
CONCLUSION: This is the first study to correlate histological results and complications following TCB and SLB in ILD subjects, some of whom underwent both procedures. TCB is a suitable diagnostic tool in ILD, potentially completely dispensing with the need for a SLB in some cases. In all cases, an interdisciplinary case evaluation is necessary as a final step. PMID: 25620578 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 26, 2015 Category: Respiratory Medicine Authors: Hagmeyer L, Theegarten D, Wohlschläger J, Treml M, Matthes S, Priegnitz C, Randerath WJ Tags: Clin Respir J Source Type: research

Effects of Dynamic Hyperinflation on Exercise Capacity and Quality of Life in Stable COPD Patients.
CONCLUSIONS: Dynamic hyperinflation develops variably during exercise and has a greater impact on maximal exercise capacity than 6MWD, even in those with the same extent of pulmonary function impairment at rest. PMID: 25620462 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 26, 2015 Category: Respiratory Medicine Authors: Zhao L, Bu X, Wang C Tags: Clin Respir J Source Type: research

What is the minimum number of patients for quality control of lung cancer management in Norway?
CONCLUSIONS: To generate precise estimates for quality control of lung cancer care in Norway, the number of management units must be reduced. Given the present willingness of chest physicians to change their procedures for management of lung cancer according to the results of quality control indicators, we recommend a maximum of 10 units with a minimum of 200 incident lung cancer patients per year for each management centre. PMID: 25620395 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - January 26, 2015 Category: Respiratory Medicine Authors: Skaug K, Eide GE, Gulsvik A Tags: Clin Respir J Source Type: research

Severe measles pneumonia in adults with respiratory failure: role of ribavirin and high dose vitamin A.
We present three adult cases (one of whom was pregnant) admitted to our University Hospital who were diagnosed to have measles and who had uncommon clinical features such as hepatitis and hyponatremia. All patients were markedly hypoxic; one required mechanical ventilation. Two patients received therapy with intravenous ribavirin and all patients received high dose vitamin A for three days. Therapy with intravenous ribavirin and vitamin A were well tolerated by our patients except one patient who developed acute renal failure and were associated with reversal of respiratory compromise. Life-threatening measles pneumonitis ...
Source: Respiratory Care - January 26, 2015 Category: Respiratory Medicine Authors: Ersoy EO, Tanriover MD, Ocal S, Ozisik L, Inkaya C, Topeli A Tags: Clin Respir J Source Type: research

Non-Communicable Diseases And Adherence To Mediterranean Diet.
Authors: Antonio C, Valeria L Abstract Non-communicable diseases (NCDs) also known as chronic diseases last for a long time and progress generally slow. Major non-communicable diseases are cardiovascular diseases, cancers, chronic respiratory diseases and diabetes. Wrong healthy lifestyles and food behaviours play an important role for determining such diseases. The changing of unhealthy behaviours or the maintenance of healthy lifestyles have an enormous value not only for individuals, with the reduction of diseases and longer life expectancy, but also for the entire community. Recent meta-analyses reported Medite...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - January 25, 2015 Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

An Algorithmic Approach to Terminal Ventilator Withdrawal: Pilot Testing (FR416-D)
Terminal ventilator withdrawal entails the cessation of invasive mechanical ventilation to allow a natural death. There is little empirical evidence to guide the conduct of this common procedure. If the process is not well conducted, patients undergoing ventilator withdrawal are at very high risk for experiencing significant respiratory distress. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - January 25, 2015 Category: Palliative Care Authors: Margaret Campbell, Michael Mendez, Hossein Yarandi Source Type: research

Palliative Care in the Seriously Mentally Ill (FR452)
The seriously mentally ill (SMI) remain an underserved population in palliative care. The relationship between SMI and poor physical health is well documented. SMI have double the risk of dying from natural causes at any given age than the general population. They are at a higher risk of death from comorbid conditions such as cancer, cardiovascular disease, and respiratory and gastrointestinal illness, leading to an average reduced life expectancy of 8-15 years. Individuals with a psychiatric disorder are at increased risk for having a comorbid substance abuse disorder. (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - January 25, 2015 Category: Palliative Care Authors: Leslie Blatt, Susan Crawford Source Type: research

Portuguese Journal of Pulmonology and Brazilian Journal of Pulmonology-"Aquele Abraço" ("A Great Big Hug")
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Gender differences in the perception of asthma and respiratory symptoms in a population sample of asthma patients in four Brazilian cities
CONCLUSIONS: Among women, asthma tends to be more symptomatic, as well as having a more pronounced effect on activities of daily living and on quality of life. OBJETIVO: Avaliar o impacto da asma em relação ao sexo em uma amostra populacional de pacientes asmáticos no Brasil. MÉTODOS: Foram entrevistados pessoalmente 400 pacientes asmáticos com idade > 12 anos de uma amostra probabilística nacional por contato telefônico nas cidades de São Paulo, Rio de Janeiro, Curitiba e Salvador. Os indivíduos responderam um questionário de 53 questões relacionadas...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Efficacy and safety of the single-capsule combination of fluticasone/formoterol in patients with persistent asthma: a non-inferiority trial
CONCLUSIONS: The single-capsule combination of FLU/FOR showed non-inferiority to the BUD/FOR and FLU formulations regarding efficacy and safety, making it a new treatment option for persistent asthma. OBJETIVO: A fluticasona e o formoterol são efetivos no tratamento da asma. A terapia combinada é o tratamento de escolha quando o corticosteroide isolado não controla a asma. O objetivo deste estudo foi comparar a eficácia e segurança de formulações contendo budesonida/formoterol (BUD/FOR), fluticasona (FLU) e fluticasona/formoterol (FLU/FOR) em cápsula única sobre a função pulmonar em...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension
CONCLUSIONS: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant. OBJETIVO: Avaliar o papel do cateterismo de câmaras cardíacas direitas no diagnóstico de hipertensão arterial pulmonar (HAP). ...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Epidemiological aspects of and risk factors for wheezing in the first year of life
CONCLUSIONS: The prevalence of wheezing in the studied population was high (56.34%). The etiology was multifactorial, and the risk factors were intrinsic and extrinsic (respiratory tract infections, allergies, attending daycare, and early wheezing). The high prevalence and the intrinsic risk factors indicate the need and the opportunity for epidemiological and genetic studies in this population. In addition, mothers should be encouraged to prolong breastfeeding and to keep infants under six months of age out of daycare. OBJETIVO: Determinar a prevalência e os fatores de risco para sibilância...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Effects of home-based respiratory muscle training in children and adolescents with chronic lung disease
CONCLUSIONS: Home-based RMT appears to be an effective strategy for increasing respiratory muscle strength in children and adolescents with CLD or NMD, although it increased the ability to cough effectively only in those with NMD. OBJETIVO: A fraqueza muscular respiratória é uma repercussão funcional da doença pulmonar crônica (DPC). O objetivo deste estudo foi avaliar os efeitos do treinamento muscular respiratório (TMR) domiciliar em crianças e adolescentes com DPC ou doença neuromuscular (DNM). MÉTODOS: Estudo quasi-experimental com crianças e adolesce...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Correlates of experimentation with smoking and current cigarette consumption among adolescents
CONCLUSIONS: Current smoking was associated with a profile of socioeconomic correlates different from that associated with experimentation only. Our data (showing that current smoking was associated with having a friend who smokes, alcohol intake, and illicit drug use) suggest the need for comprehensive approaches to discourage substance use during adolescence. OBJETIVO: Analisar características sociais e estresse como correlatos de consumo de cigarros na adolescência. O principal objetivo foi identificar elementos que distingam adolescentes que experimentaram cigarros e não progrediram par...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Quantitative culture of endotracheal aspirate and BAL fluid samples in the management of patients with ventilator-associated pneumonia: a randomized clinical trial
CONCLUSIONS: In the context of this study, the management of VAP patients, based on the results of quantitative endotracheal aspirate cultures, led to similar clinical outcomes to those obtained with the results of quantitative BAL fluid cultures. OBJETIVO: Comparar a mortalidade em 28 dias e desfechos clínicos em pacientes com pneumonia associada à ventilação mecânica (PAVM) internados em UTI conforme a estratégia diagnóstica utilizada. MÉTODOS: Ensaio clínico randomizado prospectivo. Dos 73 pacientes incluídos no estudo, 36 e 37, respectivamente, foram ...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Facial pressure zones of an oronasal interface for noninvasive ventilation: a computer model analysis
CONCLUSIONS: The computer simulation results indicate that, in patients submitted to noninvasive ventilation with an OI, the probability of skin lesion is higher in the nasal bridge and paranasal regions. This methodology could increase the applicability of biomechanical research on noninvasive ventilation interfaces, providing the information needed in order to choose the interface that best minimizes the risk of skin lesion. OBJETIVO: Estudar os efeitos de uma interface oronasal (IO) durante a ventilação não invasiva usando um modelo computacional tridimensional (3D) com a capacidade de s...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Impact of the type of mask on the effectiveness of and adherence to continuous positive airway pressure treatment for obstructive sleep apnea
This study reviews theoretical concepts and questions the premise that all types of interfaces produce similar results. We revised the evidence in the literature about the impact that the type of CPAP interface has on the effectiveness of and adherence to OSA treatment. We searched the PubMed database using the search terms "CPAP", "mask", and "obstructive sleep apnea". Although we identified 91 studies, only 12 described the impact of the type of CPAP interface on treatment effectiveness (n = 6) or adherence (n = 6). Despite conflicting results, we found no consistent evidence that nasal pillows and oral masks alter OSA t...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Infected tracheal diverticulum: a rare association with alpha-1 antitrypsin deficiency
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

A six-minute step test protocol for the investigation of dyspnea
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Preserving the intercostal nerves as a goal in thoracotomy
We report a case of a 69-year-old woman who was hospitalized after presenting with fever, fatigue, pleuritic chest pain, and a right neck mass complicated by dysphagia. Her medical history was significant: pulmonary emphysema (alpha-1 antitrypsin deficiency); bronchiectasis; and thyroidectomy. On physical examination, she presented diminished breath sounds and muffled heart sounds, with a systolic murmur. Laboratory tests revealed elevated inflammatory markers, a CT scan showed an air-filled, multilocular mass in the right tracheal wall, and magnetic resonance imaging confirmed the CT findings. Fiberoptic bronchoscopy fail...
Source: Jornal Brasileiro de Pneumologia - January 25, 2015 Category: Respiratory Medicine Source Type: research

Liver injury may increase the risk of diazoxide toxicity: a case report
Conclusion: We hypothesize that low albumin level may increase the toxicity of diazoxide, possibly by increasing the free diazoxide concentration, as this compound is typically >90 % bound to plasma proteins. What is Known: • Diazoxide binds to plasma proteins >90 % and excreted in urine. • Dose adjustment is recommended in patients with impaired kidney functions. What is Ne...
Source: European Journal of Pediatrics - January 25, 2015 Category: Pediatrics Source Type: research

Maternally inherited diabetes is associated with a homoplasmic T10003C mutation in the mitochondrial tRNAGly gene
In this report, we investigate molecular pathogenic mechanism of a diabetes-associated homoplasmic mitochondrial tRNA mutation in a Han Chinese family with maternally transmitted diabetes mellitus. Of 10 adult matrilineal relatives, 5 individuals suffered from diabetes (4 subjects with only diabetes, one subject with both diabetes and hearing impairment), while other five matrilineal relatives (one with hearing loss) had glucose intolerance. The average age at onset of diabetes in matrilineal relatives was 50years. Molecular analysis of their mitochondrial genomes identified the novel homoplasmic T10003C mutation in the tR...
Source: Mitochondrion - January 25, 2015 Category: Biochemistry Source Type: research

Nanoparticulate CpG Immunotherapy in RAO‐Affected Horses: Phase I and IIa Study
Conclusion and Clinical ImportanceAdministration of a GNP‐bound CpG‐ODN formulation caused a potent and persistent effect on allergic and inflammatory‐induced clinical variables in RAO‐affected horses. This treatment, therefore, provides an innovative, promising, and well‐tolerated strategy beyond conventional symptomatic long‐term therapy and could serve as a model for asthma treatment in humans. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - January 25, 2015 Category: Veterinary Research Authors: J. Klier, B. Lehmann, S. Fuchs, S. Reese, A. Hirschmann, C. Coester, G. Winter, H. Gehlen Tags: Standard Article Source Type: research

Respiratory Pathogens in Québec Dairy Calves and Their Relationship with Clinical Status, Lung Consolidation, and Average Daily Gain
Conclusions and Clinical ImportanceResults suggested that nasopharyngeal carriage of M. bovis was detrimental to health and growth of dairy calves in small herds with a high incidence of BRD. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - January 25, 2015 Category: Veterinary Research Authors: D. Francoz, S. Buczinski, A.M. Bélanger, G. Forté, O. Labrecque, D. Tremblay, V. Wellemans, J. Dubuc Tags: Standard Article Source Type: research

Propofol dexmedetomidine versus propofol ketamine for anesthesia of endoscopic retrograde cholangiopancreatography (ERCP) (A randomized comparative study)
Conclusion Dexmedetomidine–propofol combination as TIVA during ERCP showed better intra-and post-procedural hemodynamic stability, less PONV, less postoperative cognitive dysfunctions and shorter recovery time when compared with ketamine–propofol combination. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - January 25, 2015 Category: Anesthesiology Source Type: research