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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

SARS-CoV nsp10, a Critical Replicative Complex Co-factor [Genomics and Proteomics]
The RNA-synthesizing machinery of the severe acute respiratory syndrome Coronavirus (SARS-CoV) is composed of 16 non-structural proteins (nsp1–16) encoded by ORF1a/1b. The 148-amino acid nsp10 subunit contains two zinc fingers and is known to interact with both nsp14 and nsp16, stimulating their respective 3′-5′ exoribonuclease and 2′-O-methyltransferase activities. Using alanine-scanning mutagenesis, in cellulo bioluminescence resonance energy transfer experiments, and in vitro pulldown assays, we have now identified the key residues on the nsp10 surface that interact with nsp14. The functional consequences of mut...
Source: Journal of Biological Chemistry - September 11, 2014 Category: Chemistry Authors: Bouvet, M., Lugari, A., Posthuma, C. C., Zevenhoven, J. C., Bernard, S., Betzi, S., Imbert, I., Canard, B., Guillemot, J.–C., Lecine, P., Pfefferle, S., Drosten, C., Sniȷder, E. J., Decroly, E., Morelli, X. Tags: Microbiology Source Type: research

The Roles of miRNAs and Protein Components of the miRNA Pathway in Lung Development and Diseases.
Abstract Decades of studies have shown evolutionarily conserved molecular networks consisting of transcriptional factors, diffusing growth factors, and signaling pathways that regulate proper lung development. Recently, miRNAs, small non-coding regulatory RNAs, have been integrated into these networks. Significant advances have been made in characterizing the developmental stage- or cell type-specific miRNAs during lung development by using approaches such as genome-wide profiling and in situ hybridization. Results from gain or loss of function studies have revealed pivotal roles of protein components of the miRNA ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 11, 2014 Category: Molecular Biology Authors: Cushing L, Jiang Z, Kuang P, Lü J Tags: Am J Respir Cell Mol Biol Source Type: research

Glycated Hemoglobin, All-Cause, and Cause-Specific Mortality in Singaporean Chinese Without Diagnosed Diabetes: The Singapore Chinese Health Study.
CONCLUSION: HbA1c levels consistent with undiagnosed type 2 diabetes (≥6.5%) are associated with an increased risk of all-cause and cause-specific mortality in Chinese men and women. PMID: 25216509 [PubMed - as supplied by publisher] (Source: Diabetes Care)
Source: Diabetes Care - September 11, 2014 Category: Endocrinology Authors: Bancks MP, Odegaard AO, Pankow JS, Koh WP, Yuan JM, Gross MD, Pereira MA Tags: Diabetes Care Source Type: research

Association of Post-discharge Rehabilitation with Mortality in Intensive Care Unit Survivors of Sepsis.
Conclusions: Post-discharge rehabilitation may be associated with a reduced risk of 10-year mortality in the subset of patients with particularly long ICU courses. PMID: 25210792 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 11, 2014 Category: Respiratory Medicine Authors: Chao PW, Shih CJ, Lee YJ, Tseng CM, Kuo SC, Shih YN, Chou KT, Tarng DC, Li SY, Ou SM, Chen YT Tags: Am J Respir Crit Care Med Source Type: research

Endosonography for mediastinal nodal staging of clinical N1 non-small cell lung cancer: a prospective multicenter study.
Conclusions:Endosonography alone has an unsatisfactory sensitivity to detect mediastinal nodal metastasis in cN1 lung cancer, and the addition of a confirmatory mediastinoscopy is of added value. [clinicaltrials.gov NCT01456429]. Background: Patients with clinical N1 (cN1) lung cancer based on imaging are at risk for malignant mediastinal nodal involvement (N2-disease). Endosonography with a needle technique is suggested over surgical staging as a best first test for preoperative invasive mediastinal staging. The addition of a confirmatory mediastinoscopy seems questionable in patients with a normal mediastinum on imag...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Dooms C, Tournoy KG, Schuurbiers O, Decaluwe H, De Ryck F, Verhagen A, Beelen R, van der Heijden E, De Leyn P Tags: Chest Source Type: research

Validation of the GAP Score in Korean Patients with Idiopathic Pulmonary Fibrosis.
Conclusion:The GAP model showed similar discrimination power compared with the original cohort. But it did not predict the 3-year risk of death accurately. Further multinational validation study will be needed. Background: No study has determined whether the risk of mortality predicted by the gender, age, and physiological variables (GAP) model matches the observed mortality from idiopathic pulmonary fibrosis (IPF) in non-Western populations. We evaluated the clinical course of IPF and validated the GAP model in Korean IPF patients. Methods: We included 268 patients who had been diagnosed with IPF at Seoul National...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Kim ES, Choi SM, Lee J, Park YS, Lee CH, Yim JJ, Yoo CG, Kim YW, Han SK, Lee SM Tags: Chest Source Type: research

Direct Oral Anticoagulants in Patients with Venous Thromboembolism and Cancer: A Systematic Review and Meta-Analysis.
ConclusionsDOA seems to be as effective and safe as conventional treatment for prevention of VTE in cancer patients. Further clinical trials in patients with cancer-associated VTE should be performed to confirm these results. Background: Direct oral anticoagulants (DOA) have been shown to be as effective and at least as safe as conventional anticoagulation for the prevention of recurrences in patients with venous thromboembolism (VTE). Whether this is the case in patients with cancer-associated VTE remains undefined. Methods: We performed a meta-analysis of randomized controlled trials with the aim of assessing the...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Vedovati MC, Germini F, Agnelli G, Becattini C Tags: Chest Source Type: research

Interstitial Pneumonia Related to Undifferentiated Connective Tissue Disease: Pathologic Pattern and Prognosis.
Conclusions:A UIP pattern, which seems to be frequent in UCTD, showed a poorer prognosis than that of UCTD-NSIP. However, the prognosis of UCTD-UIP was significantly better than that of IPF, highlighting the importance of searching for underlying UCTD in suspected IPF cases. Background: Undifferentiated connective tissue disease (UCTD) involves conditions characterized by both having symptoms of connective tissue disease (CTD) and autoantibodies but they do not fulfill the criteria of a specific CTD. The frequency or prognosis of the usual interstitial pneumonia (UIP) pattern in UCTD is unknown, which may be confused w...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Kim HC, Ji W, Kim MY, Colby TV, Jang SJ, Lee CK, Han SB, Kim DS Tags: Chest Source Type: research

Echocardiographic Assessment of Estimated Right Atrial Pressure and Size Predicts Mortality in Pulmonary Arterial Hypertension.
Conclusions:Elevation of eRAP by echocardiography at baseline assessment was strongly associated with increased risk of death or transplant in patients with PAH. This measurement may represent an important prognostic component in the comprehensive echocardiographic evaluation of PAH. Background: Elevated mean right atrial pressure (RAP) measured by cardiac catheterization is an independent risk factor for mortality. Prior studies have demonstrated a modest correlation with invasive and noninvasive echocardiographic right atrial pressure (eRAP), but the prognostic impact of eRAP has not been previously evaluated in pulm...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Austin C, Alassas K, Burger C, Safford R, Pagan R, Duello K, Kumar P, Zeiger T, Shapiro B Tags: Chest Source Type: research

A Scoping Review of Patient Discharge from Intensive Care: Opportunities and Tools to Improve Care.
Conclusions:Common themes, facilitators and barriers related to patient and family needs/experiences, communication and the use of guidelines/policies to standardize patient discharge from ICU transcend the literature. Candidate tools to improve care are available, comparative evaluation is needed prior to broad implementation, and could be tested through local quality improvement programs. Background: We conducted a scoping review to systematically review the literature reporting patient discharge from intensive care units (ICU), identify facilitators and barriers to high quality care and describe tools developed to i...
Source: Chest - September 11, 2014 Category: Respiratory Medicine Authors: Stelfox HT, Lane D, Boyd JM, Taylor S, Perrier L, Straus S, Zygun D, Zuege DJ Tags: Chest Source Type: research

Alleviation of Dermatophagoides microceras-induced allergy by an immunomodulatory protein, FIP-fve, from Flammulina velutipes in mice.
Abstract Asthma is a major public health concern. Its greatest risk factor is house dust mite (HDM). Dermatophagoides microceras (Der m) is a type of HDM, and in central Taiwan, there is approximately 80% prevalence of sensitization to Der m. FIP-fve is a fungal immunomodulatory protein (FIP) isolated from the fungus Flammulina velutipes, and exhibits anti-inflammatory properties. To investigate whether FIP-fve affects Der m-induced asthma and inflammation, we evaluated hyper-responsiveness (AHR), pathological changes, and cytokines in mice. We demonstrated that oral FIP-fve decreased Der m-induced airway AHR, airw...
Source: Bioscience, Biotechnology, and Biochemistry - September 11, 2014 Category: Biochemistry Authors: Chang YC, Hsiao YM, Hung SC, Chen YW, Ou CC, Chang WT, Lue KH, Ko JL Tags: Biosci Biotechnol Biochem Source Type: research

[Antibiotic prescribing in acute respiratory tract infections in general practice.]
CONCLUSIONS: Antibiotic prescribing in respiratory tract infections in children was generally high, and the choice of antibiotics was probably inappropriate in a high percentage of cases. Therefore an improvement in antibiotic prescribing in children appears to be needed. PMID: 25220798 [PubMed - as supplied by publisher] (Source: Anales de Pediatria)
Source: Anales de Pediatria - September 11, 2014 Category: Pediatrics Authors: Malo S, Bjerrum L, Feja C, Lallana MJ, Poncel A, Rabanaque MJ Tags: An Pediatr (Barc) Source Type: research

Mini Nutritional Assessment Short‐Form predicts exacerbation frequency in patients with chronic obstructive pulmonary disease
ConclusionsThe MNA‐SF predicts COPD exacerbation independently of the CAT. (Source: Respirology)
Source: Respirology - September 10, 2014 Category: Respiratory Medicine Authors: Masanori Yoshikawa, Yukio Fujita, Yoshifumi Yamamoto, Motoo Yamauchi, Koichi Tomoda, Noriko Koyama, Hiroshi Kimura Tags: Original Article Source Type: research

Development and psychometric validation of a cystic fibrosis knowledge scale
ConclusionsThis study is an important first step in a line of research that aims to develop and empirically validate a psycho‐educational adherence intervention for improving quality of life and treatment outcomes among adult CF patients. The CF knowledge scale has potential applications as a clinical teaching tool with patients and health‐care providers and could be used as an outcome measure in CF educational intervention studies aimed at optimizing CF treatment knowledge, adherence and quality of life among CF patients. (Source: Respirology)
Source: Respirology - September 10, 2014 Category: Respiratory Medicine Authors: Louise Balfour, Michael Armstrong, Crystal Holly, Ena Gaudet, Shawn Aaron, George Tasca, William Cameron, Smita Pakhale Tags: Original Article Source Type: research

Obesity hypoventilation syndrome in Japan and independent determinants of arterial carbon dioxide levels
ConclusionsThe prevalence of OHS in OSA in Japan was 2.3%. The mean BMI of patients with OHS in Japan was lower than that in Western countries (36.7 kg/m2 vs 44.0 kg/m2). (Source: Respirology)
Source: Respirology - September 10, 2014 Category: Respiratory Medicine Authors: Yuka Harada, Yuichi Chihara, Masanori Azuma, Kimihiko Murase, Yoshiro Toyama, Chikara Yoshimura, Toru Oga, Hiroshi Nakamura, Michiaki Mishima, Kazuo Chin, Tags: Original Article Source Type: research

Forthcoming Meetings
(Source: Respirology)
Source: Respirology - September 10, 2014 Category: Respiratory Medicine Tags: FORTHCOMING MEETINGS Source Type: research

Journal Statistics
(Source: Respirology)
Source: Respirology - September 10, 2014 Category: Respiratory Medicine Tags: JOURNAL STATISTICS Source Type: research

Indoor pollutant exposure is associated with heightened respiratory symptoms in atopic compared to non-atopic individuals with COPD
Background: Indoor particulate matter (PM) has been linked to respiratory symptoms in former smokers with COPD. While subjects with COPD and atopy have also been shown to have more frequent respiratory symptoms, whether they exhibit increased susceptibility to PM as compared to their non-atopic counterparts remains unclear. The aim of this study was to determine whether atopic individuals with COPD have greater susceptibility to PM compared to non-atopic individuals with COPD. Methods: Former smokers with moderate to severe COPD were enrolled (n = 77). PM2.5, PM with diameter (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - September 10, 2014 Category: Respiratory Medicine Authors: Deepak KajiAndrew BelliMeredith McCormackElizabeth MatsuiD¿Ann WilliamsLaura PaulinNirupama PutchaRoger PengGregory DiettePatrick BreysseNadia Hansel Source Type: research

Effect of glycemic control on nocturnal arterial oxygen saturation: A case‐control study in type 2 diabetic patients
ConclusionsGlycemic control improvement significantly reduces the increased number of nocturnal oxygen desaturations that exist in type 2 diabetes. Although the mechanisms are not yet fully understood, the rapid effect without changes in body weight suggests a central mechanism involving respiratory center output. (Source: Journal of Diabetes)
Source: Journal of Diabetes - September 10, 2014 Category: Endocrinology Authors: Albert Lecube, Andreea Ciudin, Gabriel Sampol, Silvia Valladares, Cristina Hernández, Rafael Simó Tags: Original Article Source Type: research

Issue Information
(Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - September 10, 2014 Category: Infectious Diseases Tags: Issue Information Source Type: research

Trends of pre-hospital emergency medical services activity over 10 years: a population-based registry analysis
Conclusion: Routine prospective data collection of prehospital emergency interventions and monitoring of activity was feasible over time. The results we found add to the understanding of determinants of PEMS use and need to be considered to plan use of emergency health services in the near future. More comprehensive analysis of the quality of services and patient safety supported by indicators are also required, which might help to develop prehospital emergency services and new processes of care. (Source: BMC Health Services Research)
Source: BMC Health Services Research - September 10, 2014 Category: Journals (General) Authors: Valérie PittetBernard BurnandBertrand YersinPierre-Nicolas Carron Source Type: research

Acute effects of MDMA on autonomic cardiac activity and their relation to subjective prosocial and stimulant effects
Abstract MDMA is a stimulant with unique “prosocial” effects, the physiological and pharmacological mechanisms of which are unknown. Here, we examine the relationship of measures of parasympathetic and sympathetic nervous system activity to the prosocial effects of MDMA. Parasympathetic activity was measured using respiratory sinus arrhythmia (RSA) and sympathetic activity using pre‐ejection period (PEP). Over three sessions, 33 healthy volunteers received placebo, 0.75 mg/kg, and 1.5 mg/kg MDMA under counterbalanced, double‐blind conditions, while we measured subjective feelings, RSA, and PEP. RSA and PEP data...
Source: Psychophysiology - September 10, 2014 Category: Neurology Authors: Christine M. Clark, Charles G. Frye, Margaret C. Wardle, Greg J. Norman, Harriet Wit Tags: Brief Report Source Type: research

Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study
el, S F Plummer & Z Ďuračková (Source: European Journal of Clinical Nutrition)
Source: European Journal of Clinical Nutrition - September 10, 2014 Category: Nutrition Authors: I GaraiovaJ MuchováZ NagyováD WangJ V LiZ OrszághováD R MichaelS F PlummerZ Ďuračková Source Type: research

Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26.
Abstract The recently reported Middle East respiratory syndrome coronavirus (MERS-CoV) is phylogenetically closely related to the bat coronaviruses (BatCoVs) HKU4 and HKU5. However, the evolutionary pathway of MERS-CoV is still unclear. A receptor binding domain (RBD) in the MERS-CoV envelope-embedded spike protein specifically engages human CD26 (hCD26) to initiate viral entry. The high sequence identity in the viral spike protein prompted us to investigate if HKU4 and HKU5 can recognize hCD26 for cell entry. We found that HKU4-RBD, but not HKU5-RBD, binds to hCD26, and pseudotyped viruses embedding HKU4 spike can...
Source: Cell Host and Microbe - September 10, 2014 Category: Microbiology Authors: Wang Q, Qi J, Yuan Y, Xuan Y, Han P, Wan Y, Ji W, Li Y, Wu Y, Wang J, Iwamoto A, Woo PC, Yuen KY, Yan J, Lu G, Gao GF Tags: Cell Host Microbe Source Type: research

Cervical stitch (cerclage) for preventing preterm birth in multiple pregnancy.
CONCLUSIONS: This review is based on limited data from five small studies of average to above average quality. For multiple gestations, there is no evidence that cerclage is an effective intervention for preventing preterm births and reducing perinatal deaths or neonatal morbidity. PMID: 25208049 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 10, 2014 Category: Journals (General) Authors: Rafael TJ, Berghella V, Alfirevic Z Tags: Cochrane Database Syst Rev Source Type: research

Gustatory and olfactory function in patients with granulomatosis with polyangiitis (Wegener's).
Conclusions: Our results indicate that olfactory and gustatory functions are significantly decreased in GPA. As the olfactory function of these patients was comparable to patients with RA, chemosensory impairment may not simply be a consequence of the involvement of the upper respiratory tract, but rather a common complication of systemic autoimmune diseases. PMID: 25204208 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - September 10, 2014 Category: Rheumatology Authors: Proft F, Steinbach S, Dechant C, Witt M, Reindl C, Schulz S, Vielhauer V, Hilge R, Laubender R, Manger K, Nüsslein H, Wendler J, Schuch F, Schulze-Koops H, Grunke M Tags: Scand J Rheumatol Source Type: research

An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome.
Abstract The aim of this study is to characterize the function of mitochondria and main energy fluxes in human colorectal cancer (HCC) cells. We have performed quantitative analysis of cellular respiration in post-operative tissue samples collected from 42 cancer patients. Permeabilized tumor tissue in combination with high resolution respirometry was used. Our results indicate that HCC is not a pure glycolytic tumor and the oxidative phosphorylation (OXPHOS) system may be the main provider of ATP in these tumor cells. The apparent Michaelis-Menten constant (Km) for ADP and maximal respiratory rate (Vm) values were...
Source: The International Journal of Biochemistry and Cell Biology - September 10, 2014 Category: Biochemistry Authors: Kaldma A, Klepinin A, Chekulayev V, Mado K, Shevchuk I, Timohhina N, Tepp K, Kandashvili M, Varikmaa M, Koit A, Planken M, Heck K, Truu L, Planken A, Valvere V, Rebane E, Kaambre T Tags: Int J Biochem Cell Biol Source Type: research

Endogenous expression pattern of resolvin D1 in a rat model of self-resolution of lipopolysaccharide-induced acute respiratory distress syndrome and inflammation.
Abstract Resolvin D1 (RvD1), an endogenous lipid mediator derived from docosahexaenoic acid, has been reported to promote a biphasic activity in anti-inflammatory response and regulate inflammatory resolution. The present study aimed to determine the endogenous expression pattern of RvD1 in a rat model of self-resolution of lipopolysaccharide (LPS)-induced acute respiratory distress syndrome (ARDS) and inflammation. The ARDS model was induced by administrating LPS (2mg/kg) via tracheotomy in 138 male Sprague-Dawley rats. At specified time points, lung injury and inflammation were respectively assessed by lung histo...
Source: International Immunopharmacology - September 10, 2014 Category: Allergy & Immunology Authors: Sun W, Wang ZP, Gui P, Xia W, Xia Z, Zhang XC, Deng QZ, Xuan W, Marie C, Wang LL, Wu QP, Wang T, Lin Y Tags: Int Immunopharmacol Source Type: research

New steps for the international consolidation of the Brazilian Journal of Pulmonology
(Source: Jornal Brasileiro de Pneumologia)
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Brazilian recommendations of mechanical ventilation 2013. Part I
Perspectives on invasive and noninvasive ventilatory support for critically ill patients are evolving, as much evidence indicates that ventilation may have positive effects on patient survival and the quality of the care provided in intensive care units in Brazil. For those reasons, the Brazilian Association of Intensive Care Medicine (Associação de Medicina Intensiva Brasileira - AMIB) and the Brazilian Thoracic Society (Sociedade Brasileira de Pneumologia e Tisiologia - SBPT), represented by the Mechanical Ventilation Committee and the Commission of Intensive Therapy, respectively, decided to review the literature and ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Risk factors for death in patients with severe asthma
CONCLUSIONS: In this cohort of outpatients with severe asthma, the deaths occurred predominantly due to respiratory causes and within a health care facility. Lack of asthma control and male gender were risk factors for mortality. OBJETIVO: Identificar os fatores de risco para morte em pacientes com asma grave. MÉTODOS: Estudo caso-controle aninhado a uma coorte de pacientes acompanhados no Ambulatório Central de Referência do Programa para o Controle da Asma na Bahia, em Salvador (BA). No período entre dezembro de 2002 e dezembro de 2010, foram selecionados todos os pacientes com asma grave que foram a óbito e pacie...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Evaluation of von Willebrand factor in COPD patients
CONCLUSIONS: Our results suggest that increases in vWF levels and activity contribute to the persistence of systemic inflammation, as well as increasing cardiovascular risk, in COPD patients. OBJETIVO: Comparar os níveis séricos absolutos e a atividade sérica em percentual do fator de von Willebrand (FvW) em pacientes com DPOC clinicamente estáveis, tabagistas sem obstrução das vias aéreas e em indivíduos saudáveis que nunca fumaram. MÉTODOS: Foram incluídos no estudo 57 indivíduos, em três grupos: DPOC (n = 36), tabagista (n = 12) e controle (n = 9). Todos os participantes realizaram radiografia do tórax, ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Clinical application of CT and CT-guided percutaneous transthoracic needle biopsy in patients with indeterminate pulmonary nodules
CONCLUSIONS: In our sample, CT and CT-PTNB were useful in distinguishing between malignant and benign IPNs. Advanced age and smoking were significantly associated with malignancy. Certain CT findings related to IPNs (larger diameter, spiculated borders, homogeneous attenuation, and necrosis) were associated with malignancy. OBJETIVO: Investigar a aplicação clínica da TC e da biópsia transtorácica percutânea guiada por TC (BTP-TC) em pacientes com nódulos pulmonares indeterminados (NPIs). MÉTODOS: Foram estudados retrospectivamente 113 pacientes portadores de NPIs submetidos a TC e BTP-TC. Foram analisadas variáv...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Comparison between two thoracotomy closure techniques: postoperative pain and pulmonary function
CONCLUSIONS: The patients in the TS group experienced less immediate and late post-thoracotomy pain than did those in the PS group, as well as showing smaller reductions in the spirometry parameters. Therefore, transcostal suture is recommended over pericostal suture as the thoracotomy closure technique of choice. OBJETIVO: Comparar duas técnicas de fechamento de toracotomias (sutura pericostal e transcostal) em relação à dor pós-operatória e função pulmonar. MÉTODOS: Estudo prospectivo, randomizado e duplo-cego realizado no Serviço de Cirurgia Torácica do Hospital das Clínicas Luzia de Pinho Melo e na Univers...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Comparison between reference values for FVC, FEV1, and FEV1/FVC ratio in White adults in Brazil and those suggested by the Global Lung Function Initiative 2012
CONCLUSIONS: The predicted values suggested by the GLI equations for White adults were significantly lower than those used as reference values for males in Brazil. For both genders, the lower limit of the FEV1/FVC ratio is significantly lower than that predicted by the GLI equations. OBJETIVO: Comparar os valores espirométricos previstos pelas equações da Global Lung Function Initiative (GLI) em 2012, sugeridas como de uso internacional, com aqueles obtidos em uma amostra utilizada para derivação de valores de referência em adultos caucasianos brasileiros. MÉTODOS: A amostra utilizada era composta por 270 homens e...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Anemia in hospitalized patients with pulmonary tuberculosis
CONCLUSIONS: In this sample, high proportions of pulmonary tuberculosis patients were classified as underweight and malnourished, and there was a high prevalence of anemia of chronic disease. In addition, anemia was associated with high ESR and malnutrition. OBJETIVO: Descrever a prevalência de anemia e de seus tipos em pacientes internados com tuberculose pulmonar. MÉTODOS: Estudo descritivo e longitudinal com pacientes com tuberculose pulmonar hospitalizados em dois hospitais de referência na cidade do Rio de Janeiro (RJ). Foram avaliados o índice de massa corpórea (IMC), dobra cutânea tricipital (DCT), área musc...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Oxidative damage induced by cigarette smoke exposure in mice: impact on lung tissue and diaphragm muscle,
CONCLUSION: Our data demonstrate that CS exposure produces oxidative damage, not only in lung tissue but also (primarily) in muscle tissue, having an additional effect on respiratory muscle, as is frequently observed in smokers with COPD. OBJETIVO: Avaliar o dano oxidativo (oxidação lipídica, oxidação proteica, thiobarbituric acid-reactive substances [TBARS, substâncias reativas ao ácido tiobarbitúrico], e carbonilação) e inflamação (expressão de phosphorylated AMP-activated protein kinase e de phosphorylated mammalian target of rapamycin (p-AMPK e p-mTOR, respectivamente) em tecido pulmonar e músculos do dia...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats
We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil ...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.Nosso objetivo foi determinar os nív...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Overview of the biochemical and genetic processes in malignant mesothelioma
The objective of this study was to review the literature regarding the processes of malignant transformation, as well as the respective mechanisms of tumorigenesis, in MM.O mesotelioma maligno (MM) é um câncer extremamente agressivo, com elevado período de latência e resistente aos protocolos de quimioterapia, além de ser extremamente fatal, com taxa de sobrevivência média inferior a um ano. O desenvolvimento do MM é fortemente correlacionado com a exposição ao amianto e erionita, assim como ao vírus símio 40. Apesar de vários países terem banido o uso de amianto, o MM tem se mostrado de difícil controle e s...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Use of volume-targeted non-invasive bilevel positive airway pressure ventilation in a patient with amyotrophic lateral sclerosis,
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Accessory cardiac bronchus causing recurrent pulmonary infection
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research

Ground-glass nodules and CT-guided placement of platinum coils
We present the case of a 66-year-old woman with ALS and respiratory failure treated with volume-targeted BPAP ventilation for 15 weeks. Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive positive pressure ventilation, whereas tidal volume and minute ventilation remained relatively constant.A esclerose lateral amiotrófica (ELA) é uma doença neurodegenerativa progressiva. A maioria dos pacientes com ELA falece por insuficiência respiratória. Embora a ventilação não invasiva com dois níveis...
Source: Jornal Brasileiro de Pneumologia - September 9, 2014 Category: Respiratory Medicine Source Type: research