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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

The Lung Microbiome in Idiopathic Pulmonary Fibrosis. What Does It Mean and What Should We Do about It?
PMID: 25317462 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Morris A, Gibson K, Collman RG Tags: Am J Respir Crit Care Med Source Type: research

Lipoxins and epoxyeicosatrienoic acids. Potential for inhibitors of soluble epoxide hydrolase in severe asthma?
PMID: 25317461 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Chung KF Tags: Am J Respir Crit Care Med Source Type: research

Groundhog day: airway narrowing, deep inspirations, and asthma.
PMID: 25317460 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Brown RH Tags: Am J Respir Crit Care Med Source Type: research

Defective Innate Immunity and Hyper-Inflammation in Newborn CFTR-Knockout Ferret Lungs.
Abstract Mucociliary clearance (MCC) and submucosal glands (SMGs) are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although both of these defense systems develop post-natally in the ferret, the lungs of newborn ferrets remain sterile in the presence of a functioning cystic fibrosis transmembrane conductance regulator (CFTR) gene. We evaluated several components of airway innate immunity and inflammation in the early CF ferret lung. At birth, the rates of MCC did not differ between CF and non-CF animals, but the height of the airway surface liquid was significantly ...
Source: Am J Respir Cell Mol... - October 15, 2014 Category: Respiratory Medicine Authors: Keiser NW, Birket SE, Evans IA, Tyler SR, Crooke AK, Sun X, Zhou W, Nellis JR, Stroebele EK, Chu KK, Tearney GJ, Stevens MJ, Harris JK, Rowe SM, Engelhardt JF Tags: Am J Respir Cell Mol Biol Source Type: research

SHP2 and FAK Protein Interactions Regulate Pulmonary Endothelium Barrier Function.
Abstract Enhanced protein tyrosine phosphorylation (PTP) is associated with changes in vascular permeability through formation and dissolution of adherens junctions and regulation of stress fiber formation. Inhibition of the PTP, SHP2, increases tyrosine phosphorylation of VE-cadherin and β-catenin, resulting in disruption of the endothelial monolayer and edema formation in the pulmonary endothelium. Vascular permeability is a hallmark of acute lung injury (ALI), thus enhanced SHP2 activity offers potential therapeutic value for the pulmonary vasculature in diseases such as ALI; however this has not been character...
Source: Am J Respir Cell Mol... - October 15, 2014 Category: Respiratory Medicine Authors: Chichger H, Braza J, Duong H, Harrington EO Tags: Am J Respir Cell Mol Biol Source Type: research

Muscle Weakness and Speech in Oculopharyngeal Muscular Dystrophy.
Conclusions: Despite having less than half the maximal tongue strength of healthy controls, the individuals with OPMD exhibited minimal speech deficits. The threshold of weakness required for noticeable speech impairment may not have been reached by this group of adults with OPMD. PMID: 25321879 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)
Source: Journal of speech, language, and hearing research : JSLHR - October 15, 2014 Category: Speech Therapy Authors: Neel AT, Palmer PM, Sprouls G, Morrison L Tags: J Speech Lang Hear Res Source Type: research

Timing of fat and liquid sugar intake alters substrate oxidation and food efficiency in male Wistar rats.
Abstract In addition to the amount of ingested calories, both timing of food intake and meal composition are determinants of body weight gain. However, at present, it is unknown if the inappropriate timing of diet components is responsible for body weight gain. In the present study, we therefore studied a time-dependent effect of the diet composition on energy homeostasis. Male Wistar rats were subjected to chow ad libitum (chow group) or a choice diet with saturated fat, a 30% sugar solution, chow and tap water. The choice diet was provided either with all components ad libitum (AL), with ad libitum access to chow...
Source: Chronobiology International - October 15, 2014 Category: Biology Authors: Oosterman JE, Foppen E, van der Spek R, Fliers E, Kalsbeek A, la Fleur SE Tags: Chronobiol Int Source Type: research

Inefficient transmissibility of NS-truncated H3N8 equine influenza virus in dogs.
Abstract H3N8 Equine influenza virus (EIV) causes respiratory diseases in horse population, and it has been demonstrated that EIV can transmit into dogs due to its availability on receptors of canine respiratory epithelial cells. Recently, we isolated H3N8 EIV from EIV vaccinated horse that showed symptoms of respiratory disease, and which has partially truncated nonstructural gene (NS). However, it is not clear that the NS-truncated EIV has an ability to cross the host species barrier from horses to dogs as well. Here, we experimentally infect the NS-truncated H3N8 EIV into dogs, and monitored their clinical signs...
Source: Journal of Microbiology and Biotechnology - October 15, 2014 Category: Biotechnology Authors: Na W, Song M, Yeom M, Park N, Kang B, Moon H, Jeong DG, Kim JK, Song D Tags: J Microbiol Biotechnol Source Type: research

Proposal of Novosphingobium rhizosphaerae sp. nov., isolated from the rhizosphere.
Abstract A yellow pigmented, Gram-negative, rod-shaped, non-spore-forming bacterium (strain JM-1T), was isolated from the rhizosphere of a field-grown Zea mays plant in Auburn, Alabama, U.S.A. The 16S rRNA gene sequence analysis of strain JM-1T showed high sequence similarity to the type strains of Novosphingobium capsulatum (98.9%), Novosphingobium aromaticivorans (97.4%), Novosphingobium subterraneum (97.3%), and Novosphingobium taihuense (97.1%), sequence similarities to all other Novosphingobium species type strains were below 97.0%. DNA-DNA hybridizations of strain JM-1T and N. capsulatum DSM 30196T, N. aromat...
Source: International Journal of Systematic and Evolutionary Microbiology - October 15, 2014 Category: Microbiology Authors: Kämpfer P, Martin K, McInroy JA, Glaeser SP Tags: Int J Syst Evol Microbiol Source Type: research

Inhaled colistimethate sodium in ventilator-associated tracheobronchitis due to multidrug-resistant Gram-negative bacteria
Respiratory tract infections result in significant morbidity and mortality among critically ill patients, particularly in those receiving mechanical ventilation [1]. Ventilator-associated pneumonia (VAP) is associated with prolonged mechanical ventilation, intensive care unit (ICU) stay, high medical costs and death [1]. Ventilator-associated tracheobronchitis (VAT) is thought to be an intermediate process between colonisation of the lower respiratory tract and VAP. Although antibiotic treatment for VAT has been controversial, recent randomised trials suggest potential benefits with this approach [2]. (Source: Internationa...
Source: International Journal of Antimicrobial Agents - October 15, 2014 Category: Drugs & Pharmacology Authors: Luis Patricio Maskin, Mariano Setten, Pablo O. Rodríguez, Ignacio Bonelli, Shiry Attie, Martin E. Stryjewski, Ricardo Valentini Tags: Letter to the Editor Source Type: research

Differential Diagnosis in Paradoxical Vocal Fold Movement (PVFM): An Interdisciplinary Task
The objective of this study was to contribute to the discussion of differential diagnosis in paradoxical vocal fold movement (PVFM), a disorder frequently associated with episodes of breathing difficulty and stridor. Because of analogous respiratory symptoms, PVFM is often misdiagnosed as asthma. Additional evidence suggests the association of factors such as respiratory struggle during physical exertion, digestive reflux, and respiratory allergies with PVFM, particularly in athletes and young females. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - October 15, 2014 Category: ENT & OMF Authors: Maria Claudia Franca Source Type: research

Home care agencies target breathing problems
During the past year, hospitals started getting dinged by Medicare when patients with chronic breathing problems were readmitted to the hospital within a month of discharge. Penalties for the fiscal year that began Oct. 1 range up to 3 percent, an amount that has risen in recent years. Now, agencies that provide medical equipment and care in the home are responding with respiratory care programs that aim to reduce early readmissions. Bridgeville-based AdvaCare Home Services and Klingensmith HealthCare… (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - October 14, 2014 Category: Hospital Management Authors: Kris B. Mamula Source Type: research

Short-term effects of subchronic low-level hydrogen sulfide exposure on oil field workers
Conclusions Nasal mucosa was the most vulnerable part to H2S effect. Inhalation of H2S produced upper respiratory tract epithelial damage that led to bleeding from nose, pharynx, gum, tongue, trachea, and bronchi. There were no complaints of asthmatic attack upon exposure to low level of H2S. Sunlight had a significant role in reduction of ambient air H2S level. (Source: Environmental Health and Preventive Medicine)
Source: Environmental Health and Preventive Medicine - October 14, 2014 Category: Environmental Health Source Type: research

Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension
Conclusion Measurements of excessive exercise ventilation which consider all data points maximize the usefulness of incremental cardiopulmonary exercise testing in the prognosis evaluation of PAH. (Source: European Journal of Preventive Cardiology)
Source: European Journal of Preventive Cardiology - October 14, 2014 Category: Cardiology Authors: Ferreira, E. V., Ota-Arakaki, J. S., Ramos, R. P., Barbosa, P. B., Almeida, M., Treptow, E. C., Valois, F. M., Nery, L. E., Neder, J. A. Tags: Original scientific paper Source Type: research

A retrospective review of a tertiary Hospital¿s isolation and de-isolation policy for suspected pulmonary tuberculosis
Background: Effective protocols for the isolation and de-isolation of patients with suspected pulmonary tuberculosis (PTB) are essential determinants of health-care costs. Early de-isolation needs to be balanced with the need to prevent nosocomial transmission of PTB. The aim of our study was to evaluate the efficiency of our hospital?s current protocol for isolating and de-isolating patients with suspected PTB, in particular assessing the timeliness to de-isolation of patients with AFB smear negative respiratory samples. Methods: We retrospectively reviewed 121 patients with suspected PTB who were admitted to our hospital...
Source: BMC Infectious Diseases - October 14, 2014 Category: Infectious Diseases Authors: Shirin KalimuddinJeanne TanBan TanJenny Low Source Type: research

Staging and Outcome in Acute Exacerbation of Idiopathic Pulmonary Fibrosis: Are All Limits and Determinants Under Control?
(Source: Lung)
Source: Lung - October 14, 2014 Category: Respiratory Medicine Source Type: research

A retrospective review of a tertiary Hospital’s isolation and de-isolation policy for suspected pulmonary tuberculosis
Background: Effective protocols for the isolation and de-isolation of patients with suspected pulmonary tuberculosis (PTB) are essential determinants of health-care costs. Early de-isolation needs to be balanced with the need to prevent nosocomial transmission of PTB. The aim of our study was to evaluate the efficiency of our hospital’s current protocol for isolating and de-isolating patients with suspected PTB, in particular assessing the timeliness to de-isolation of patients with AFB smear negative respiratory samples. Methods: We retrospectively reviewed 121 patients with suspected PTB who were admitted to our hospit...
Source: Epidemiologic Perspectives and Innovations - October 14, 2014 Category: Epidemiology Authors: Shirin KalimuddinJeanne TanBan TanJenny Low Source Type: research

Tour of a Labyrinth: Exploring the Vertebrate Nose
ABSTRACT This special issue of The Anatomical Record is the outcome of a symposium entitled “Inside the Vertebrate Nose: Evolution, Structure and Function.” The skeletal framework of the nasal cavity is a complicated structure that often houses sinuses and comprises an internal skeleton of bone or cartilage that can vary greatly in architecture among species. The nose serves multiple functions, including olfaction and respiratory air‐conditioning, and its morphology is constrained by evolution, development, and conflicting demands on cranial space, such as enlarged orbits. The nasal cavity of vertebrates has received...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 14, 2014 Category: Molecular Biology Authors: Blaire Valkenburgh, Timothy D. Smith, Brent A. Craven Tags: Special Article Source Type: research

Respiratory and Olfactory Turbinals in Feliform and Caniform Carnivorans: The Influence of Snout Length
ABSTRACT To enhance bite force at the canines, feliform carnivorans have short rostra relative to caniform carnivorans. Rostral reduction in feliforms results in less rostrocaudal space for the maxilloturbinals, the complex set of bones involved in conditioning inspired air and conserving water. It is unknown whether the maxilloturbinals might show adaptations to adjust for this loss, such as greater complexity than what is observed in longer snouted caniforms. To understand the impact of rostral shortening on turbinals in feliforms, we used high resolution CT scans to quantify turbinal surface areas (SA) in 16 feliforms a...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 14, 2014 Category: Molecular Biology Authors: Blaire van Valkenburgh, Benison Pang, Deborah Bird, Abigail Curtis, Karen Yee, Charles Wysocki, Brent A. Craven Tags: Special Article Source Type: research

Reconstruction and Morphometric Analysis of the Nasal Airway of the White‐Tailed Deer (Odocoileus virginianus) and Implications Regarding Respiratory and Olfactory Airflow
ABSTRACT Compared with other mammals (e.g., primates, rodents, and carnivores), the form and function of the ungulate nasal fossa, in particular the ethmoidal region, has been largely unexplored. Hence, the nasal anatomy of the largest prey species remains far less understood than that of their predators, rendering comparisons and evolutionary context unclear. Of the previous studies of nasal anatomy, none have investigated the detailed anatomy and functional morphology of the white‐tailed deer (Odocoileus virginianus), a species that is ubiquitous throughout North and Central America and in northern regions of South Ame...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 14, 2014 Category: Molecular Biology Authors: Allison N. Ranslow, Joseph P. Richter, Thomas Neuberger, Blaire Valkenburgh, Christopher R. Rumple, Andrew P. Quigley, Benison Pang, Michael H. Krane, Brent A. Craven Tags: Special Article Source Type: research

Breathing Life Into Dinosaurs: Tackling Challenges of Soft‐Tissue Restoration and Nasal Airflow in Extinct Species
ABSTRACT The nasal region plays a key role in sensory, thermal, and respiratory physiology, but exploring its evolution is hampered by a lack of preservation of soft‐tissue structures in extinct vertebrates. As a test case, we investigated members of the “bony‐headed” ornithischian dinosaur clade Pachycephalosauridae (particularly Stegoceras validum) because of their small body size (which mitigated allometric concerns) and their tendency to preserve nasal soft tissues within their hypermineralized skulls. Hypermineralization directly preserved portions of the olfactory turbinates along with an internal nasal ridge...
Source: The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology - October 14, 2014 Category: Molecular Biology Authors: Jason M. Bourke, WM. Ruger Porter, Ryan C. Ridgely, Tyler R. Lyson, Emma R. Schachner, Phil R. Bell, Lawrence M. Witmer Tags: Special Article Source Type: research

Central nervous system alterations caused by infection with the human respiratory syncytial virus
SUMMARY Worldwide, the human respiratory syncytial virus (hRSV) is the leading cause of infant hospitalization because of acute respiratory tract infections, including severe bronchiolitis and pneumonia. Despite intense research, to date there is neither vaccine nor treatment available to control hRSV disease burden globally. After infection, an incubation period of 3–5 days is usually followed by symptoms, such as cough and low‐grade fever. However, hRSV infection can also produce a larger variety of symptoms, some of which relate to the individual's age at infection. Indeed, infants can display severe symptoms, suc...
Source: Reviews in Medical Virology - October 14, 2014 Category: Virology Authors: Karen Bohmwald, Janyra A. Espinoza, Pablo A. González, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis Tags: Review Source Type: research

Dynamic preload indicators decrease when the abdomen is opened
Conclusions: Opening of the abdomen decreases PPV and SVV. During goal directed therapy, current thresholds for fluid responsiveness should be changed accordingly. (Source: BMC Anesthesiology)
Source: BMC Anesthesiology - October 14, 2014 Category: Anesthesiology Authors: Martijn van LavierenJeroen VeelenturfCharlotte HofhuizenMarion van der KolkJohannes van der HoevenPeter PickkersJoris LemsonBenno Lansdorp Source Type: research

Opioid-induced respiratory depression: ABCB1 transporter pharmacogenetics
& J McAuliffe (Source: The Pharmacogenomics Journal)
Source: The Pharmacogenomics Journal - October 14, 2014 Category: Drugs & Pharmacology Authors: S SadhasivamV ChidambaranX ZhangJ MellerH EsslingerK ZhangL J MartinJ McAuliffe Source Type: research

Metformin in reproductive health, pregnancy and gynaecological cancer: established and emerging indications
CONCLUSIONS Obesity is on the rise in developing countries and is strongly linked to several reproductive health problems, including PCOS, GDM and endometrial cancer. Traditional lifestyle measures aimed at weight reduction are challenging to implement and maintain. Metformin may be a valuable alternative to, or adjunct for, modifying the toxic effects of obesity in these populations. This review will appraise the evidence for the use of metformin for the prevention and treatment of adverse health outcomes in obstetrics and gynaecology. (Source: Human Reproduction Update)
Source: Human Reproduction Update - October 14, 2014 Category: OBGYN Authors: Sivalingam, V. N., Myers, J., Nicholas, S., Balen, A. H., Crosbie, E. J. Tags: Reviews Source Type: research

Determinants of use of the bronchodilator test in primary and secondary care: results of a national survey in Spain
ConclusionThe present study identifies determinants of the performance of the BDT in Spain identifying strengths and weaknesses. Health managers should use this information to improve the quality of spirometries in chronic respiratory patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 14, 2014 Category: Respiratory Medicine Authors: Jose Luis Lopez‐Campos, Joan B. Soriano, Myriam Calle, Tags: Original Article Source Type: research

Red cell distribution width in patients with sarcoidosis
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 14, 2014 Category: Respiratory Medicine Authors: Sevket Balta, Mehmet Aydogan, Mustafa Aparci, Cengiz Ozturk, Sait Demirkol Tags: Letter to the Editor Source Type: research

Prototype development of an electrical impedance based simultaneous respiratory and cardiac monitoring system for gated radiotherapy
Conclusion: The developed system capable of rendering quality signals for tracking both respiratory and cardiac motions can potentially provide a solution for simultaneous dual-gated radiotherapy. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 14, 2014 Category: Biomedical Engineering Authors: Kirpal KohliJeff LiuDevin SchellenbergAnand KarvatAsh ParameswaranParvind GrewalSteven Thomas Source Type: research

Pneumococcal Infections at Hajj: Current Knowledge Gaps.
Abstract Hajj attendance increases the risk of respiratory infections including pneumonia. Streptococcus pneumoniae is a frequently identified pathogen, found in about 10% of respiratory tract samples of symptomatic Hajj pilgrims; and at least 20% of these isolates are penicillin resistant. However, the burden of pneumococcal disease at Hajj is not precisely defined at serotypic level, and it is postulated that due to intense mixing of pilgrims the distribution of pneumococcal serotypes at Hajj could be different from pilgrims' country of origin or of Saudi Arabia. In Saudi Arabia, the most prevalent pneumococcal s...
Source: Infectious Disorders Drug Targets - October 14, 2014 Category: Infectious Diseases Authors: Ridda I, King C, Rashid H Tags: Infect Disord Drug Targets Source Type: research

The Threat of Human Influenza: the Viruses, Disease Impacts, and Vaccine Solutions.
Abstract Influenza is an acute respiratory illness that remains an important cause of excessive morbidity and mortality with substantial economic cost to the population. Influenza, being a virus that frequently mutates, is not amenable to elimination. Vaccination remains the most effective preventive measure. This review summarises the latest developments in the fields of biology and epidemiology relating to clinical and economic impacts of influenza disease, and vaccination. We suggest that future efforts should focus on developing safer, more effective, and cost-effective prophylactic vaccines for influenza. ...
Source: Infectious Disorders Drug Targets - October 14, 2014 Category: Infectious Diseases Authors: Yin JK, Salkeld G, Heron L, Khandaker G, Rashid H, Booy R Tags: Infect Disord Drug Targets Source Type: research

Acquired unilateral pulmonary vein atresia in a 3-year-old boy
We present a 3-year-old boy who presented with mild respiratory distress. Neonatal echocardiographic investigations revealed normal mediastinal anatomy and pulmonary vasculature with a bicuspid aortic valve. However, follow-up Doppler investigation revealed a pulmonary artery size difference with minimal forward flow and reverse flow during diastole. Absence of the left pulmonary veins and the presence of collaterals draining to the innominate vein confirmed the diagnosis of acquired UPVA. Our case represents the first case of acquired UPVA in conjunction with a normally functioning bicuspid aortic valve. The Doppler flow ...
Source: Journal of Ultrasound - October 14, 2014 Category: Radiology Source Type: research

Cardiac, ventilatory, and metabolic adjustments in chronic obstructive pulmonary disease patients during the performance of Glittre activities of daily living test.
The objective of this study was to evaluate the cardiac, respiratory, and metabolic adjustments and reproducibility of the Glittre ADL test performed by COPD patients. Twenty-two mild to severe COPD patients (forced expiratory volume in 1 second (FEV1): 56.6 ± 19.9% predicted; mean age: 66.3 ± 9.18 years old) were enrolled in this study. Metabolic (oxygen uptake (VO2), carbon dioxide production (VCO2), pulmonary ventilation (VE)/VCO2, and VE/VO2), ventilatory (tidal volume, respiratory rate, and VE), and cardiovascular (pulse oxygen saturation, VO2/heart rate (HR), and HR) variables, lower limbs fatigue, and dyspnea (Bor...
Source: Chronic Respiratory Disease - October 14, 2014 Category: Respiratory Medicine Authors: Tufanin A, Souza GF, Tisi GR, Tufik S, de Mello MT, Nascimento OA, Jardim JR Tags: Chron Respir Dis Source Type: research

Aerosol Distribution During Open Suctioning and Long-Term Surveillance of Air Quality in a Respiratory Care Center Within a Medical Center.
CONCLUSIONS: RCC air quality deserves long-term monitoring and evaluation. Health-care workers must implement self-protection strategies during open suctioning to ensure their occupational health and safety in health-care settings. PMID: 25316895 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Chung FF, Lin HL, Liu HE, Lien AS, Hsiao HF, Chou LT, Wan GH Tags: Respir Care Source Type: research

Should Patients With COPD Be Vaccinated?
CONCLUSIONS: Physicians should be more aware of vaccination and recommend both influenza and pneumococcal vaccines to all patients with COPD to reduce exacerbations. PMID: 25316894 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Cimen P, Unlu M, Kirakli C, Katgi N, Ucsular FD, Ayranci A, Guclu SZ Tags: Respir Care Source Type: research

The Difference Between Slow and Forced Vital Capacity Increases With Increasing Body Mass Index: A Paradoxical Difference in Low and Normal Body Mass Indices.
CONCLUSIONS: Our results indicate that FVC is larger than SVC in patients with low and normal BMI and no evidence of obstruction in the PFTs, whereas FVC is smaller than SVC in overweight and obese individual. Our findings add to the existing literature that use of FEV1/FVC may lead to underdiagnosis of obstructive airway disease in overweight and obese individuals. PMID: 25316893 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Fortis S, Corazalla EO, Wang Q, Kim HJ Tags: Respir Care Source Type: research

Late-Onset Pompe Disease With Left-Sided Bronchomalacia.
We describe the case of a 16-y-old girl with late-onset Pompe disease who presented with obvious progressive deterioration in respiratory function. Pulmonary hypertension was also apparent on echocardiography. She had been on enzyme replacement therapy and nighttime CPAP ventilation for several years. Flexible bronchoscopy was used for diagnosis and subsequent implantation of a bronchial airway stent. Following implantation of the stent, the patient's pulmonary function stabilized, and her pulmonary hypertension resolved. The patient continued on enzyme replacement therapy and nighttime CPAP ventilation. This case highligh...
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Yang CF, Niu DM, Jeng MJ, Lee YS, Taso PC, Soong WJ Tags: Respir Care Source Type: research

Golden Tracheal Secretions and Bronchoalveolar Fluid During Acute Chest Syndrome in Sickle Cell Disease.
Abstract Acute chest syndrome (ACS) is the leading cause of ICU admission in patients with sickle cell disease and is characterized by golden sputum, which is commonly attributed to the presence of bilirubin. Three young consecutive patients with homozygous sickle cell disease were admitted for severe acute respiratory syndrome due to ACS. In all 3 patients, tracheal secretions and bronchoalveolar lavage fluid (BALF) showed a yellowish plasma-like stain. After normalization for the plasma-to-BAL urea ratio, BALF protein and lactate dehydrogenase levels were consistent with an exudative process. BALF bilirubin conce...
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Contou D, Dessap AM, Carteaux G, Brun-Buisson C, Maitre B, de Prost N Tags: Respir Care Source Type: research

An Unusual Cause of Refractory Hypoxemia in Cirrhosis.
We report the clinical presentation of an unusual portosystemic anatomic shunt that permits venous admixture with oxygenated blood, causing hypoxemia that is refractory to the administration of supplemental oxygen, and recurrent hepatic encephalopathy. There has been no such report in the published literature. This case highlights the importance of keeping direct portopulmonary venous anastomosis in the differential diagnosis of oxygen-refractory hypoxemia and recurrent hepatic encephalopathy in patients with cirrhosis in the appropriate clinical context. PMID: 25316890 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Patidar Y, Kumar S Tags: Respir Care Source Type: research