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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Increased intrinsic mitochondrial respiratory capacity in skeletal muscle from rats with streptozotocin‐induced hyperglycemia
This article demonstrates results that provide novel insight to how a state of hyperglycemia affects the intrinsic bioenergetics in muscles with predominantly type 1 and type 2 fibers, respectively. (Source: Physiological Reports)
Source: Physiological Reports - July 21, 2015 Category: Physiology Authors: Steen Larsen, Celena Scheede‐Bergdahl, Thomas Whitesell, Robert Boushel, Andreas Bergdahl Tags: Original Research Source Type: research

Investigation into FlhFG reveals distinct features of FlhF in regulating flagellum polarity in Shewanella oneidensis
In this study, we show that FlhFG of Shewanella oneidensis (SoFlhFG), a monotrichous γ‐proteobacterium renowned for respiratory diversity, also play an important role in the flagellar polar placement and number control. Despite this, SoFlhFG exhibit distinct features that are not observed in the characterized counterparts. Most strikingly, the G domain of SoFlhF determines the polar placement, contrasting the N domain of the V. cholerae FlhF. The SoFlhF N domain in fact counteracts the function of the G domain with respect to the terminal targeting in the absence of the B domain. We further show that GTPase activity of ...
Source: Molecular Microbiology - July 21, 2015 Category: Microbiology Authors: Tong Gao, Miaomiao Shi, Lili Ju, Haichun Gao Tags: Research Article Source Type: research

Risk factors for Mycobacterium avium subsp. paratuberculosis (MAP) and Mycobacterium bovis coinfection at individual animal level in southern Chile cattle populations
This study provided regionally based data that may be used to design future control plans for both cattle infections in southern Chile. (Source: Tropical Animal Health and Production)
Source: Tropical Animal Health and Production - July 21, 2015 Category: Veterinary Research Source Type: research

Aspirin provocation increases 8-iso-PGE2 in exhaled breath condensate of aspirin-hypersensitive asthmatics
Conclusion A significant increase of exhaled 8-iso-PGE2 after inhalatory challenge with aspirin was selective and not present for the other isoprostane measured. This is a novel finding in AERD, suggesting that inhibition of cyclooxygenase may elicit 8-iso-PGE2 production in a specific mechanism, contributing to bronchoconstriction and systemic overproduction of cysteinyl leukotrienes. (Source: Prostaglandins and Other Lipid Mediators)
Source: Prostaglandins and Other Lipid Mediators - July 21, 2015 Category: Lipidology Source Type: research

Variation in Outpatient Antibiotic Prescribing for Acute Respiratory Infections in the Veteran Population: A Cross-sectional Study.
CONCLUSION: Veterans with ARIs commonly receive antibiotics, regardless of patient, provider, or setting characteristics. Macrolide use has increased, and substantial variation was identified in antibiotic prescribing at the provider level. PRIMARY FUNDING SOURCE: U.S. Department of Veterans Affairs, Centers for Disease Control and Prevention. PMID: 26192562 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - July 21, 2015 Category: Internal Medicine Authors: Jones BE, Sauer B, Jones MM, Campo J, Damal K, He T, Ying J, Greene T, Goetz MB, Neuhauser MM, Hicks LA, Samore MH Tags: Ann Intern Med Source Type: research

A regulatory CD9+ B cell subset inhibits HDM‐induced allergic airway inflammation
This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - July 21, 2015 Category: Allergy & Immunology Authors: F Braza, J Chesne, M Durand, S Dirou, G Mahay, M A Cheminant, A Magnan, S Brouard Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Bispectral index-guided general anaesthesia in combination with interscalene block reduces desflurane consumption in arthroscopic shoulder surgery: a clinical comparison of bupivacaine versus levobupivacaine
Background: The goal of this study was to compare the influence of an interscalene brachial plexus block (ISB) performed with either bupivacaine or levobupivacaine in conjunction with general anaesthesia (GA) on desflurane consumption, which was titrated to maintain the recovery profiles and postoperative analgesia while also keeping the bispectral index score (BIS) between 40 and 60 in patients undergoing arthroscopic shoulder surgery. Methods: Sixty patients undergoing arthroscopic shoulder surgery were prospectively randomized to receive GA with desflurane alone (group C) or in combination with a preoperative ISB by eit...
Source: BMC Anesthesiology - July 21, 2015 Category: Anesthesiology Authors: Levent OzturkElvin KesimciTuna AlbayrakOrhan Kanbak Source Type: research

Antimicrobial drug prescribing patterns for community-acquired pneumonia in hospitalized patients: A retrospective pilot study from New Delhi, India
Conclusions : These findings suggest the need for implementing antimicrobial treatment guidelines. Adequate documentation and monitoring of antibiotic use for feedback are also lacking. An antimicrobial stewardship program may offer the most comprehensive solution for appropriate use of antimicrobials. (Source: Indian Journal of Pharmacology)
Source: Indian Journal of Pharmacology - July 21, 2015 Category: Drugs & Pharmacology Authors: Anita KotwaniSantosh KumarPrafulla Kumar SwainJC SuriSN Gaur Source Type: research

The effects of Anesthesia and opioids on the upper airway: A systematic review
ConclusionsStudies assessing the effect of anesthesia on the upper airway in patients with and without OSA are limited, and few compare effects between agents. Medications with minimal effect on respiratory control (e.g., dexmedetomidine) may work best for DISE. Laryngoscope, 2015 (Source: The Laryngoscope)
Source: The Laryngoscope - July 21, 2015 Category: ENT & OMF Authors: Zarmina Ehsan, Mohamed Mahmoud, Sally R. Shott, Raouf S. Amin, Stacey L. Ishman Tags: Sleep Medicine Source Type: research

Factors influencing the development of otitis media among Sicilian children affected by upper respiratory tract infections
Conclusions URTIs and OM are common childhood diseases strongly associated with low parental educational attainment (p =0.0001), exposure to smoke (p =0.0001), indoor exposure to mold (p =0.0001), LPRD (p =0.0002) and the lack of breast-feeding (p =0.0014); an increased risk of OM recurrences was observed in the presence of allergy, persistent cough and runny nose (p =0.0001). The modification of the identified risk factors for OM should be recommended to realize a correct primary care intervention. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - July 21, 2015 Category: ENT & OMF Source Type: research

Impact of cardiovascular comorbidities on COPD Assessment Test (CAT) and its responsiveness to pulmonary rehabilitation in patients with moderate to very severe COPD: protocol of the Chance study
Introduction Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Patients with COPD are characterised by a reduced health status, which can be easily assessed by the COPD Assessment Test (CAT). Previous studies show that health status can be worsened by the presence of comorbidities. However, the impact of cardiovascular comorbidities on health status as assessed with CAT is not sufficiently investigated. Therefore, the current study has the following objectives: (1) to study the clinical, (patho)physiological and psychosocial determinants of the CAT, and impact of previously establish...
Source: BMJ Open - July 21, 2015 Category: Journals (General) Authors: Smid, D. E., Wilke, S., Jones, P. W., Muris, J. W. M., Wouters, E. F. M., Franssen, F. M. E., Spruit, M. A. Tags: Open access, Cardiovascular medicine, Rehabilitation medicine, Research methods, Respiratory medicine Protocol Source Type: research

New treatment strategies for pulmonary sarcoidosis: antimetabolites, biological drugs, and other treatment approaches
Publication date: Available online 20 July 2015 Source:The Lancet Respiratory Medicine Author(s): Robert P Baughman, Jan C Grutters About half of patients with sarcoidosis will need systemic therapy for their disease. Oral glucocorticoids are the standard first-line treatment for sarcoidosis. With time, patients might develop substantial morbidity from long-term use of high doses of these drugs. We propose a step-wise approach to the management of pulmonary disease in sarcoidosis and provide details about how and when to use alternatives to glucocorticoids. The antimetabolites, such as methotrexate, azathioprine, leflu...
Source: The Lancet Respiratory Medicine - July 21, 2015 Category: Respiratory Medicine Source Type: research

Urban Particulate Matter-activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2 and Th17 Effector Cells.
Abstract Exposure to urban particulate matter (UPM) exacerbates asthmatic lung inflammation, but suppresses lung immunity to infections. Lung dendritic cells (DCs) are critical for stimulating T-cell immunity and in maintaining airway tolerance, but also react to airway UPM. The adjuvant role of UPM in enhancing primary immune responses by naive cells to allergen has been reported, but the direct effects of UPM-activated DCs on the functionality of human memory CD4 T-cells, which constitute the majority of T-cells in the lung, has not been investigated. Blood CD1c+ DCs were purified and activated with UPM in the pr...
Source: American Journal of Respiratory Cell and Molecular Biology - July 21, 2015 Category: Molecular Biology Authors: Matthews NC, Pfeffer PE, Mann EH, Kelly FJ, Corrigan CJ, Hawrylowicz CM, Lee TH Tags: Am J Respir Cell Mol Biol Source Type: research

Quality of Life and Bronchial Hyper-Responsiveness in Subjects With Bronchiectasis: Validation of the Seattle Obstructive Lung Disease Questionnaire in Bronchiectasis.
CONCLUSIONS: The SOLQ is a valid instrument for determining quality of life in subjects with bronchiectasis. Subjects with bronchiectasis and bronchial hyper-responsiveness had a poorer quality of life, lower baseline spirometric values, and more frequent exacerbations, suggesting more severe disease. PMID: 26199452 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 21, 2015 Category: Respiratory Medicine Authors: Bulcun E, Arslan M, Ekici A, Ekici M Tags: Respir Care Source Type: research

Monitoring Dead Space in Mechanically Ventilated Children: Volumetric Capnography Versus Time-Based Capnography.
CONCLUSIONS: In mechanically ventilated children without significant hypoxemia or with cardiac output-related dead-space changes, physiologic VD/VT was highly correlated with AVDSF and alveolar VD/VT. In children with significant hypoxemia, physiologic VD/VT was poorly correlated with AVDSF. Alveolar VD/VT and AVDSF correlated well in most tested circumstances. Therefore, AVDSF may be useful in most children for alveolar dead-space monitoring. PMID: 26199451 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 21, 2015 Category: Respiratory Medicine Authors: Bhalla AK, Rubin S, Newth CJ, Ross P, Morzov R, Soto-Campos G, Khemani R Tags: Respir Care Source Type: research

Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models.
Abstract Nrf2 is a key transcription factor for antioxidant response element (ARE)-bearing genes involved in diverse host defense functions including redox balance, cell cycle, immunity, mitochondrial biogenesis, energy metabolism, and carcinogenesis. Nrf2 in the airways is particularly essential as the respiratory system continuously interfaces with environmental stress. Since Nrf2 was determined to be a susceptibility gene for a model of acute lung injury, its protective capacity in the airways has been demonstrated in experimental models of human disorders using Nrf2 mutant mice which were susceptible to supple...
Source: Archives of Toxicology - July 21, 2015 Category: Toxicology Authors: Cho HY, Kleeberger SR Tags: Arch Toxicol Source Type: research

Brevirhabdus pacifica gen. nov., sp. nov., isolated from deep-sea sediment in a hydrothermal vent field.
Abstract A Gram-stain-negative, motile, aerobic bacterial strain, designated 22DY15T, was isolated from a deep-sea sediment sample collected from a hydrothermal vent field located in the East Pacific Rise. The isolate was a short rod with single flagellum and was positive for catalase and oxidase activities. Q-10 was the predominant respiratory quinone. The major polar lipids consisted of phosphatidylglycerol, phosphatidylethanolamine, phosphatidylcholine, phosphoglycolipid, one aminolipid and three unidentified phospholipids. The principal fatty acid (> 70 %) is C18:1ω7c. The genomic DNA G + C content was 64.3...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2015 Category: Microbiology Authors: Wu YH, Xu L, Zhou P, Wang CS, Oren A, Xu XW Tags: Int J Syst Evol Microbiol Source Type: research

Vogesella amnigena sp. nov., isolated from a freshwater river.
Abstract A bacterial strain, designated Npb-02T, was isolated from a freshwater river in Taiwan and characterized using a polyphasic taxonomic approach. Cells of strain Npb-02T were Gram-stain-negative, aerobic, poly--hydroxybutyrate-accumulating, rod-shaped and non-motile. Growth occurred at 15-40 °C (optimum, 25-30 °C), at pH 7.0-8.0 (optimum, pH 7.0) and with 0-1 % NaCl (optimum, 0.5 %). Phylogenetic analyses based on 16S rRNA gene sequences showed that strain Npb-02T belonged to the genus Vogesella and was most closely related to Vogesella perlucida DS-28T with sequence similarity of 98.3 %. Strain Npb-02T...
Source: International Journal of Systematic and Evolutionary Microbiology - July 21, 2015 Category: Microbiology Authors: Chen WM, Chen JC, Wang C, Huang CW, Sheu SY Tags: Int J Syst Evol Microbiol Source Type: research

[Evaluation of Nurse Demand Management in Primary Care].
DISCUSSION: Nurse demand management has shown to be highly effective at handling the conditions attended, while it provides a high percentage of health advice and education during consultations. PMID: 26209014 [PubMed - as supplied by publisher] (Source: Atencion Primaria)
Source: Atencion Primaria - July 21, 2015 Category: Primary Care Authors: Brugués Brugués A, Peris Grao A, Pavón Rodríguez F, Mateo Viladomat E, Gascón Ferret J, Flores Mateo G Tags: Aten Primaria Source Type: research

What motivates antibiotic dispensing in accredited drug dispensing outlets in Tanzania? A qualitative study
Conclusion: To reduce inappropriate antibiotic use, integrated interventions must include communities, health facilities, and ADDOs. Periodic refresher training with an emphasis on communication skills is crucial in helping dispensers deal with customers who demand antibiotics. Responsible authorities should ensure that ADDOs always have the necessary tools and resources available. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - July 20, 2015 Category: Epidemiology Authors: Angel DillipMartha EmbreyElizabeth ShekalagheDennis Ross-DegnanCatherine Vialle-ValentinSuleiman KimattaJafary LianaEdmund RuttaRichard ValimbaJohn Chalker Source Type: research

Biomarkers in interstitial lung disease: moving towards composite indexes and multimarkers?
Abstract Interstitial lung disease (ILD) covers a large spectrum of lung disorders that affects the parenchyma and is often associated with inflammation and/or fibrosis. Clinically, there is a great need for biomarker development for these disorders, to help diagnosis, treatment selection and assessment of efficacy as well as to predict progression. Thus far, no broadly validated biomarker exists for ILD, due to the existence of a very large number of disorders of often-unknown etiology, overlapping symptoms and disorders associated with a spectrum of multi-morbidities involving similar chronic inflammatory and fi...
Source: Current Respiratory Care Reports - July 20, 2015 Category: Respiratory Medicine Source Type: research

Pediatric pulmonology year in review 2014: Part 2
Summary To better meet the needs of our readership for updated perspectives on the rapidly expanding knowledge in our field, we here summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. This is Part 2 of a series and covers articles on neonatal lung disease, pulmonary physiology, and respiratory infection. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 20, 2015 Category: Respiratory Medicine Authors: Terry L. Noah, Richard Auten, Jurgen Schwarze, Stephanie Davis Tags: Review Source Type: research

Translation, cultural adaptation, and validation of the Sleep Apnea Quality of Life Index (SAQLI) in Persian-speaking patients with obstructive sleep apnea
Conclusion The findings of this study indicate that the Persian version of SAQLI is a reliable, valid, and responsive measure for evaluation of quality of life in patients with OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 20, 2015 Category: Respiratory Medicine Source Type: research

Acute exposure to silica nanoparticles aggravate airway inflammation: different effects according to surface characteristics.
This study examined the effects of acute exposure to SNPs, either alone or in conjunction with ovalbumin (OVA), by studying the respiratory systems in exposed mouse models. Three types of SNPs were used: spherical SNPs (S-SNPs), mesoporous SNPs (M-SNPs), and PEGylated SNPs (P-SNPs). In the acute SNP exposure model performed, 6-week-old BALB/c female mice were intranasally inoculated with SNPs for 3 consecutive days. In the OVA/SNPs asthma model, the mice were sensitized two times via the peritoneal route with OVA. Additionally, the mice endured OVA with or without SNP challenges intranasally. Acute SNP exposure induced sig...
Source: exp Mol Med - July 20, 2015 Category: Molecular Biology Authors: Park HJ, Sohn JH, Kim YJ, Park YH, Han H, Park KH, Lee K, Choi H, Um K, Choi IH, Park JW, Lee JH Tags: Exp Mol Med Source Type: research

An unusual cause of sore throat and neck swelling
From the question on page 625 Clinical introduction A 61-year-old man presented with swelling of the neck. He had experienced coughing, fever and sore throat for the previous few days and had been started on antibiotic treatment by his general practitioner. He presented to the emergency department because the symptoms failed to subside and he developed swelling of his neck. On examination, he was afebrile, and a hard, 9x4 cm in size, mobile mass with no redness was observed on the right side of his neck (figure 1). Question What is your diagnosis?Pneumonia Tuberculosis Q fever Lemierre's syndrome Mononucleosis For the...
Source: Emergency Medicine Journal - July 20, 2015 Category: Emergency Medicine Authors: Turedi, S., Turkmen, S., Yadigaroglu, M. Tags: Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Pain (neurology), EMJ Image Challenge, Venous thromboembolism, Radiology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Source Type: research

Spectrum of patients intentionally poisoned with an emulsified concentrate pendimethalin herbicide
Discussion and conclusions Physicians should be aware that patients who have been poisoned with pendimethalin herbicide, and particularly patients with a depressed mental state and X-ray abnormalities at presentation, may exhibit metabolic acidosis, hypotension, respiratory failure or pancreatitis. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - July 20, 2015 Category: Emergency Medicine Authors: Moon, J., Chun, B. Tags: Pancreas and biliary tract, Poisoning/Injestion, Poisoning Original article Source Type: research

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis
Conclusions The proposed image analysis-based tumour viability assessment resulted in a high agreement with expert annotations. By providing extraction of detailed information of the tumour microenvironment, the automated method can be used in preclinical research settings. The method could also have implications in cancer diagnostics, cancer outcome prognostics and prediction. (Source: Journal of Clinical Pathology)
Source: Journal of Clinical Pathology - July 20, 2015 Category: Pathology Authors: Turkki, R., Linder, N., Holopainen, T., Wang, Y., Grote, A., Lundin, M., Alitalo, K., Lundin, J. Tags: Open access, Lung cancer (oncology), Lung cancer (respiratory medicine) Original article Source Type: research

Variation in Hospitalization for Lower Respiratory Tract Infections
This cross-sectional, population-based study of children hospitalized at one institution for lower respiratory tract infections between 2010 and 2013 determines whether the rates varied geographically across a single county and whether such variability was associated with socioeconomic conditions. (Source: JAMA Pediatrics)
Source: JAMA Pediatrics - July 20, 2015 Category: Pediatrics Source Type: research

Our struggle to implement best practices: the example of antibiotic prescription for respiratory tract infection
(Source: Family Practice)
Source: Family Practice - July 20, 2015 Category: Primary Care Authors: Norman, W. V. Tags: Editorial Source Type: research

Inappropriate antibiotic prescription for respiratory tract indications: most prominent in adult patients
Conclusion. Awareness of indications and patient groups provoking antibiotic overprescribing can help in the development of targeted strategies to improve GPs’ prescribing routines for RTIs. (Source: Family Practice)
Source: Family Practice - July 20, 2015 Category: Primary Care Authors: Dekker, A. R. J., Verheij, T. J. M., van der Velden, A. W. Tags: Health Service Research Source Type: research

Validity of a clinical model to predict influenza in patients presenting with symptoms of lower respiratory tract infection in primary care
Conclusion. The Flu-Score attributes a small subgroup of patients with a high influenza risk (prevalence 32%). However, clinical usefulness is limited because this group is small and the association between predicted and observed risks is poor. Considerable diagnostic imprecision remains when it comes to differentiating those with influenza on clinical grounds from the many other causes of LRTI in primary care. New point of care tests are required that accurately, rapidly and cost effectively detect influenza in patients with respiratory tract symptoms in primary care. (Source: Family Practice)
Source: Family Practice - July 20, 2015 Category: Primary Care Authors: van Vugt, S. F., Broekhuizen, B. D., Zuithoff, N. P., van Essen, G. A., Ebell, M. H., Coenen, S., Ieven, M., Lammens, C., Goossens, H., Butler, C. C., Hood, K., Little, P., Verheij, T. J., the GRACE Consortium Tags: Health Service Research Source Type: research

Application of Multiplex PCR Coupled with Matrix-Assisted Laser Desorption Ionization-Time of Flight Analysis for Simultaneous Detection of 21 Common Respiratory Viruses [Virology]
Respiratory infections continue to pose a significant threat to human health. It is important to accurately and rapidly detect respiratory viruses. To compensate for the limits of current respiratory virus detection methods, we developed a 24-plex analysis (common respiratory virus-mass spectrometry [CRV-MS]) that can simultaneously detect and identify 21 common respiratory viruses based on a matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry system. To evaluate the efficacy of the CRV-MS method, we used 102 samples that were confirmed positive for these common respiratory viruse...
Source: Journal of Clinical Microbiology - July 20, 2015 Category: Microbiology Authors: Zhang, C., Xiao, Y., Du, J., Ren, L., Wang, J., Peng, J., Jin, Q. Tags: Virology Source Type: research

Development and Evaluation of an Enterovirus D68 Real-Time Reverse Transcriptase PCR Assay [Virology]
We have developed and evaluated a real-time reverse transcriptase PCR (RT-PCR) assay for the detection of human enterovirus D68 (EV-D68) in clinical specimens. This assay was developed in response to the unprecedented 2014 nationwide EV-D68 outbreak in the United States associated with severe respiratory illness. As part of our evaluation of the outbreak, we sequenced and published the genome sequence of the EV-D68 virus circulating in St. Louis, MO. This sequence, along with other GenBank sequences from past EV-D68 occurrences, was used to computationally select a region of EV-D68 appropriate for targeting in a strain-spe...
Source: Journal of Clinical Microbiology - July 20, 2015 Category: Microbiology Authors: Wylie, T. N., Wylie, K. M., Buller, R. S., Cannella, M., Storch, G. A. Tags: Virology Source Type: research

Development and Evaluation of Novel Real-Time Reverse Transcription-PCR Assays with Locked Nucleic Acid Probes Targeting Leader Sequences of Human-Pathogenic Coronaviruses [Virology]
Based on findings in small RNA-sequencing (Seq) data analysis, we developed highly sensitive and specific real-time reverse transcription (RT)-PCR assays with locked nucleic acid probes targeting the abundantly expressed leader sequences of Middle East respiratory syndrome coronavirus (MERS-CoV) and other human coronaviruses. Analytical and clinical evaluations showed their noninferiority to a commercial multiplex PCR test for the detection of these coronaviruses. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - July 20, 2015 Category: Microbiology Authors: Chan, J. F.-W., Choi, G. K.-Y., Tsang, A. K.-L., Tee, K.-M., Lam, H.-Y., Yip, C. C.-Y., To, K. K.-W., Cheng, V. C.-C., Yeung, M.-L., Lau, S. K.-P., Woo, P. C.-Y., Chan, K.-H., Tang, B. S.-F., Yuen, K.-Y. Tags: Virology Source Type: research

Severe Enterovirus 68 Respiratory Illness in Children Requiring Intensive Care Management
Enterovirus 68 (EV-D68) was identified from oropharyngeal swabs of 4 children hospitalized with acute lower respiratory tract illness (LRTI) in 1962 [1]. EV-D68 has features of both enteroviruses and rhinoviruses and is associated with respiratory symptoms [2,3]. Many multiplex PCR assays used in clinical practice do not distinguish between the two species, so the manifestations and severity of EV-D68 have not been well characterized. Previous epidemiologic studies have been primarily retrospective,[4–7], and rates of detection have been (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 20, 2015 Category: Virology Authors: Jennifer E. Schuster, Jenna O. Miller, Rangaraj Selvarangan, Gina Weddle, Marita T. Thompson, Ferdaus Hassan, Shannon L. Rogers, M.Steven Oberste, W.Allan Nix, Mary Anne Jackson Source Type: research

Noninvasive Mechanical Ventilation in Helicopter Emergency Medical Services Saves Time and Oxygen and Improves Patient and Mission Safety: A Pilot Study
Publication date: July–August 2015 Source:Air Medical Journal, Volume 34, Issue 4 Author(s): Jose Ignacio Garrote, Diego Aylagas, Jose M. Gutierrez, Juan A. Sinisterra, Brian Mc Gowran, Alberto Medina, Javier Díaz-Tendero, Pablo Gómez-Calcerrada, Ricardo Crespo Noninvasive mechanical ventilation (NIMV) is used increasingly in patients with severe respiratory distress and has clear benefits over standard medical therapy (SMT) in terms of patient safety. NIMV is particularly useful in cardiogenic acute pulmonary edema and in exacerbations of chronic obstructive pulmonary disease, both of which are frequent rea...
Source: Air Medical Journal - July 20, 2015 Category: Emergency Medicine Source Type: research

Presentations to Alberta Emergency Departments for Asthma: A Time Series Analysis
ConclusionsRates of ED presentations for asthma have been declining in this province during the past decade. The reasons for this decline warrant further exploration. The SARIMA models quantified the temporal patterns and may be helpful for planning research and health care service needs. (Source: Academic Emergency Medicine)
Source: Academic Emergency Medicine - July 20, 2015 Category: Emergency Medicine Authors: Rhonda J. Rosychuk, Erik Youngson, Brian H. Rowe Tags: Original Contribution Source Type: research

Clinical Reasoning: An unusual diagnostic triad
A 44-year-old woman with a history of hypothyroidism taking daily levothyroxine was admitted to an outside hospital with subacute cognitive decline. Her symptoms had started 3 weeks previously with headache, sore neck, and upper respiratory symptoms for which she sought care at a local emergency room. She did not complain of confusion or demonstrate signs of cognitive decline at that time and was discharged home with a prescription for antibiotics. A few days later, she was hospitalized after appearing disoriented, exhibiting signs of confusion, responding slowly, and running into things at work. (Source: Neurology)
Source: Neurology - July 20, 2015 Category: Neurology Authors: Francis, A. W., Kiernan, C. L., Huvard, M. J., Vargas, A., Zeidman, L. A., Moss, H. E. Tags: All Clinical Neurology, All Neuro-ophthalmology, Retina, Visual loss, All Cognitive Disorders/Dementia RESIDENT AND FELLOW SECTION Source Type: research

Clinical Reasoning: A 44-year-old woman with rapidly progressive weakness and ophthalmoplegia
A 41-year-old woman with active IV and subcutaneous heroin use complicated by recurrent methicillin-resistant Staphylococcus aureus endocarditis presented to the emergency department with 2 days of progressive dyspnea. Two days prior to presentation, she had 2 episodes of vomiting and one of diarrhea, but no headache, fever, chills, weakness, numbness, or confusion. While in the emergency department, she developed hypoxic respiratory failure requiring intubation and was admitted to the medical intensive care unit. (Source: Neurology)
Source: Neurology - July 20, 2015 Category: Neurology Authors: Schreck, K. C., Schneider, L., Geocadin, R. G. Tags: All Infections, Other toxicology, EMG, Critical care, All Education RESIDENT AND FELLOW SECTION Source Type: research

Sudden death in epilepsy: Where is the "heart" of the problem?
Every year, 5,000 people with epilepsy die of sudden unexpected death (SUDEP) in the United States alone, a reflection of a 20-fold increased risk of this devastating complication compared to the general population.1 Patients with uncontrolled seizures are particularly vulnerable. So, our knee-jerk reaction as neurologists trying to understand SUDEP has been to investigate various theories of how seizures can cause sudden death: after all, patients with epilepsy are dying, so of course the brain must be at the heart of the problem. Tremendous past and ongoing efforts have investigated various potential seizure-related cons...
Source: Neurology - July 20, 2015 Category: Neurology Authors: Jehi, L., Schuele, S. Tags: All epidemiology, All Epilepsy/Seizures EDITORIALS Source Type: research

Effect of comorbidity on mortality in multiple sclerosis
Conclusion: In the MS population, survival remained shorter than expected. Within the MS population, comorbidity was associated with increased mortality risk. However, comorbidity did not preferentially increase mortality risk in the MS population as compared with controls. (Source: Neurology)
Source: Neurology - July 20, 2015 Category: Neurology Authors: Marrie, R. A., Elliott, L., Marriott, J., Cossoy, M., Blanchard, J., Leung, S., Yu, N. Tags: Multiple sclerosis, All epidemiology ARTICLE Source Type: research

Optimizing inhaler use by pharmacist-provided education to community-dwelling elderly
To assess, using a standard observational tool, the ability of patients to demonstrate and maintain proper inhaled medication administration techniques following pharmacist education. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - July 20, 2015 Category: Respiratory Medicine Authors: Carla Bouwmeester, Jacqueline Kraft, Kathleen M. Bungay Tags: Short communication Source Type: research

Ethical dilemmas with the use of ECMO as a bridge to transplantation
Publication date: Available online 19 July 2015 Source:The Lancet Respiratory Medicine Author(s): Robert D Truog, Ravi R Thiagarajan, Charlotte H Harrison (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - July 20, 2015 Category: Respiratory Medicine Source Type: research