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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Level of asthma control and its relationship with medication use in asthma patients in Brazil
CONCLUSIONS: Our findings suggest that, in accordance with the established international criteria, asthma is uncontrolled in the vast majority of asthma patients in Brazil. Maintenance medications are still underutilized in Brazil, and patients with partially controlled or uncontrolled asthma are more likely to use rescue medications and oral corticosteroids. OBJETIVO: Avaliar pacientes asmáticos no Brasil em relação ao grau de controle da asma, a aderência ao tratamento de manutenção e o uso de medicação de alivio em pacientes asmáticos. MÉTODOS: Foram utilizados os dados de um inquérito latino-americano, obti...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Utility of the combination of serum highly-sensitive C-reactive protein level at discharge and a risk index in predicting readmission for acute exacerbation of COPD,
CONCLUSIONS: Serum hsCRP-D and GOLD classification are independent predictors of readmission for AECOPD, and their predictive value increases when they are used in combination. OBJETIVO: Reinternações frequentes por exacerbações agudas da DPOC (EADPOC) são um fator de risco independente para maior mortalidade e uso de recursos de saúde. A gravidade da doença e o nível de proteína C reativa (PCR) são preditores validados do prognóstico em longo prazo para tais pacientes. Investigamos a utilidade da combinação do nível sérico de PCR com a classificação de risco de exacerbação da Global Initiative for Chron...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Barriers associated with reduced physical activity in COPD patients
CONCLUSIONS: Patients with COPD are less active than are healthy adults of a comparable age. Physical inactivity and the barriers to performing ADL have immediate implications for clinical practice, calling for early intervention measures. OBJETIVO: Avaliar a capacidade de portadores de DPOC em realizar atividades de vida diária (AVD), identificar barreiras que impedem a sua realização, e correlacionar essas barreiras com gravidade da dispneia, teste de caminhada de seis minutos (TC6) e um escore de limitação de AVD. MÉTODOS: Nos pacientes com DPOC e controles saudáveis pareados por idade, o número de passos, a di...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Assessment of inhaler techniques employed by patients with respiratory diseases in southern Brazil: a population-based study
CONCLUSIONS: In this sample, the most common errors in the use of inhalers were not exhaling prior to inhalation, not performing a breath-hold after inhalation, and not shaking the MDI prior to use. Special attention should be given to education regarding inhaler techniques for patients of lower socioeconomic status and with less formal education, as well as for those of advanced age, because those populations are at a greater risk of committing errors in their use of inhalers. OBJETIVO: Conhecer os erros na técnica de uso de dispositivos inalatórios empregada por pacientes com doenças respiratórias no sul do Brasil e ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Effects of Pilates mat exercises on muscle strength and on pulmonary function in patients with cystic fibrosis
CONCLUSIONS: Our results show that Pilates mat exercises have beneficial effects on respiratory muscle strength in CF patients. OBJETIVO: Analisar os efeitos do método Pilates em pacientes com fibrose cística (FC). MÉTODOS: Foi realizado um ensaio clínico, casuística de 19 pacientes com FC. Os pacientes foram recrutados no Ambulatório de FC do Hospital de Clínicas da Universidade Estadual de Campinas e no Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Todos os pacientes foram submetidos a uma sessão semanal de Pilates de 60 min durante quatro meses. As vari...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Air stacking: effects on pulmonary function in patients with spinal muscular atrophy and in patients with congenital muscular dystrophy,
CONCLUSIONS: Routine daily air-stacking maneuvers with a manual resuscitator appear to increase UPCF and APCF in patients with NMD, especially in those without scoliosis. OBJETIVO: As complicações respiratórias são as principais causas de morbidade e mortalidade em pacientes com doenças neuromusculares (DNM). Os objetivos deste estudo foram determinar os efeitos que o treinamento diário domiciliar com manobras de empilhamento de ar tem na função respiratória de pacientes com amiotrofia espinhal (AE) e distrofia muscular congênita (DMC), e identificar possíveis associações entre deformidades na coluna vertebral...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Thoracic textilomas: CT findings
CONCLUSIONS: It is important to recognize the main tomographic aspects of thoracic textilomas in order to include this possibility in the differential diagnosis of chest pain and cough in patients with a history of heart or thoracic surgery, thus promoting the early identification and treatment of this postoperative complication. OBJETIVO: Analisar retrospectivamente os aspectos encontrados em TCs de tórax com textiloma torácico. MÉTODOS: Estudo retrospectivo de 16 pacientes (11 homens e 5 mulheres) com diagnóstico de textiloma torácico confirmado cirurgicamente. As TCs de tórax foram avaliadas, de modo independente...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Spatial analysis of deaths from pulmonary tuberculosis in the city of São Luís, Brazil
CONCLUSIONS: The sociodemographic and operational characteristics of the deaths from pulmonary tuberculosis evaluated in this study, as well as the identification of priority areas for control and surveillance of the disease, could promote public health policies aimed at reducing health inequities, allowing the optimization of resources, as well as informing decisions regarding the selection of strategies and specific interventions targeting the most vulnerable populations. OBJETIVO: Caracterizar os óbitos por tuberculose pulmonar em São Luís (MA) segundo variáveis sociodemográficas e operacionais e descrever sua dist...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Effects of prednisone on eosinophilic bronchitis in asthma: a systematic review and meta-analysis,
CONCLUSIONS: In patients with moderate-to-severe eosinophilic bronchitis, treatment with prednisone caused a significant reduction in sputum eosinophil counts, as well as in the sputum levels of IL-5 and ECP. This reduction in the inflammatory response was accompanied by a significant increase in post-bronchodilator FEV1. OBJETIVO: Avaliar o tamanho do efeito do tratamento com prednisona oral na bronquite eosinofílica na asma por meio de revisão sistemática e meta-análise. MÉTODOS: Revisão sistemática de artigos nas bases de dados do Medline, Cochrane Controlled Trials Register, EMBASE e LILACS. Foram selecionados...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

The electronic cigarette: the new cigarette of the 21st century?
The objective of this study was to describe electronic cigarettes and their components, as well as to review the literature regarding their safety; their impact on smoking initiation and smoking cessation; and regulatory issues related to their use.O cigarro eletrônico é um sistema eletrônico de liberação de nicotina que está gerando controvérsias, tanto entre a população quanto entre profissionais da saúde. O uso crescente do cigarro eletrônico é observado em tabagistas de diversos países, tanto para auxiliar na cessação do tabagismo quanto como substituto do cigarro convencional. Dados sobre a segurança d...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Chiari malformation and central sleep apnea syndrome: efficacy of treatment with adaptive servo-ventilation
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Digital drainage system: how far can we go?
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Battery ingestion: an unusual cause of mediastinitis
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Comments on the introduction of the paper "Overview of the biochemical and genetic processes in malignant mesothelioma"
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Authors' reply
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Erratum
This report demonstrates the efficacy of servo-ventilation in the treatment of central sleep apnea syndrome associated with alveolar hypoventilation in a CM-I patient with a history of decompressive surgery.A malformação de Chiari tipo I (MC-I) tem sido associada a distúrbios respiratórios do sono, sobretudo à síndrome de apneia central do sono. Apresentamos o caso de uma paciente do sexo feminino de 44 anos de idade com MC-I que foi encaminhada à nossa unidade de sono por suspeita de apneia do sono. A paciente havia sido submetida a cirurgia descompressiva 3 anos antes. A gasometria arterial mostrou hipercapnia. A ...
Source: Jornal Brasileiro de Pneumologia - November 22, 2014 Category: Respiratory Medicine Source Type: research

Natural history of incidental pulmonary nodules in children
CONCLUSIONOur review of 36 patients with pulmonary nodules shows no obvious growth of the nodules over the study period, suggesting low risk of malignancy. Routine follow‐up chest computer tomography using ACCP/Fleischner Society guidelines may not apply in children without known malignancy. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - November 22, 2014 Category: Respiratory Medicine Authors: Dagnachew Assefa, Arthur B. Atlas Tags: Original Article Source Type: research

Ultrasound-Guided Lung Recruitment in a 3-Month-Old Infant With Acute Respiratory Distress Syndrome
We report a case of US-guided lung recruitment procedure applied in an infant with severe acute respiratory distress syndrome and advocate that the lung US-guided RM in infants is a feasible and safe procedure. (Source: Ultrasound Quarterly)
Source: Ultrasound Quarterly - November 22, 2014 Category: Radiology Tags: Case Reports Source Type: research

Mitochondrial Myopathy, Cardiomyopathy, and Pontine Signal Changes in an Adult Patient With Isolated Complex II Deficiency
This report describes a patient who presented with myopathy, dilated cardiomyopathy, and pontine signal changes on magnetic resonance imaging. Muscle biopsy showed total absence of succinate dehydrogenase on enzyme histochemistry, negative succinate dehydrogenase subunit A (SDHA) activity on immunohistochemistry, and ultrastructural evidence of mitochondrial aggregates of varying sizes confirming the diagnosis of complex II deficiency. A unique phenotype with complex II deficiency is reported. (Source: Journal of Clinical Neuromuscular Disease)
Source: Journal of Clinical Neuromuscular Disease - November 22, 2014 Category: Neurology Tags: Short Report Source Type: research

Acute Respiratory Failure Onset in a Patient With Guillain–Barré Syndrome After Legionella-Associated Pneumonia: A Case Report
AbstractA 69-year-old white man was admitted because of a clinical history of persistent cough and fever. Chest x-rays showed bilateral lung infiltrates with air bronchograms, whereas the urine antigen test resulted positive for Legionella pneumophila. The next day, he was transferred to the intensive care unit and intubated because of severe renal and respiratory distress. Neurological examination revealed distal weakness and loss of deep tendon reflexes in lower extremities. Nerve conduction studies displayed severe demyelinating sensorimotor polyneuropathy, and plasmapheresis was therefore applied with mild improvement....
Source: Journal of Clinical Neuromuscular Disease - November 22, 2014 Category: Neurology Tags: Short Report Source Type: research

Hospitalization Due to Co-Morbid Conditions is the Main Cost Driver Among Subjects With COPD–A Report From the Population-Based OLIN COPD Study
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 22, 2014 Category: Respiratory Medicine Tags: article Source Type: research

[Comment] Antenatal corticosteroids 40 years on: we can do better
In 1972, Liggins and Howie reported results of their landmark randomised controlled trial of antenatal corticosteroids for the prevention of respiratory distress syndrome associated with preterm birth. That trial provided clear evidence for the drug's efficacy to reduce respiratory distress syndrome and mortality in the 1218 infants enrolled. However, it was not until the publication of a consensus statement by the US National Institutes of Health (22 years and 12 trials later, involving an additional 2138 infants), that this simple and cost-effective treatment was widely adopted. (Source: LANCET)
Source: LANCET - November 22, 2014 Category: Journals (General) Authors: Stuart R Dalziel, Caroline A Crowther, Jane E Harding Tags: Comment Source Type: research

Role of Pediatricians in the Ambulatory Care of Children in Taiwan, 1999-2011
Conclusions The role of pediatricians in children’s ambulatory care increased in importance from 1999 to 2011 in Taiwan. However, approximately 2/3 children sought ambulatory medical help from non-pediatric physicians. It is important to educate and encourage parents to visit pediatricians if their children require medical help. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - November 22, 2014 Category: Perinatology & Neonatology Source Type: research

Successful use of sugammadex for caesarean section in a patient with myasthenia gravis
We described the second report about use of sugammadex after rocuronium for a caesarean delivery with myasthenia gravis, but, unlike our case that formerly was diagnosed with myasthenia gravis, the patient was extubated on postoperative successfully and we did not encounter any respiratory problems. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - November 22, 2014 Category: Anesthesiology Source Type: research

Continuous positive airway pressure and noninvasive ventilation in prehospital treatment of patients with acute respiratory failure: a systematic review of controlled studies
Continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV) are frequently used inhospital for treating respiratory failure, especially in treatment of acute cardiogenic pulmonary edema and exacerbation of chronic obstructive pulmonary disease. Early initiation of treatment is important for success and introduction already in the prehospital setting may be beneficial. Our goal was to assess the evidence for an effect of prehospital CPAP or NIV as a supplement to standard medical treatment alone on the following outcome measures; mortality, hospital length of stay, intensive care unit length of stay, and in...
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - November 22, 2014 Category: Emergency Medicine Authors: Skule BakkeMorten BotkerIngunn RiddervoldHans KirkegaardErika Christensen Source Type: research

The R292K Mutation That Confers Resistance to Neuraminidase Inhibitors Leads to Competitive Fitness Loss of A/Shanghai/1/2013 (H7N9) Influenza Virus in Ferrets
Conclusions The NA inhibitor-resistant H7N9 virus with the NA-R292K mutation may transmit among ferrets but showed compromised fitness in vivo while in competition with the wild-type virus. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - November 22, 2014 Category: Infectious Diseases Authors: Yen, H.-L., Zhou, J., Choy, K.-T., Sia, S. F., Teng, O., Ng, I. H., Fang, V. J., Hu, Y., Wang, W., Cowling, B. J., Nicholls, J. M., Guan, Y., Peiris, J. S. M. Tags: VIRUSES Source Type: research

Prevalence and determinants of self-reported chronic bronchitis among women in rural Central India
Conclusions The present study provides an insight into the prevalence of chronic bronchitis among rural women exposed to several epidemiological determinants and an opportunity to address the modifiable risk factors. (Source: Medical Journal Armed Forces India)
Source: Medical Journal Armed Forces India - November 22, 2014 Category: Journals (General) Source Type: research

Outbreak control of community acquired pneumonia in a large military training institution
Conclusion The study highlights the importance of Streptococcus pneumoniae as a causative organism for outbreaks of community acquired pneumonia (CAP) in large residential training institutions and reiterates the need for formulating a policy for continuous surveillance. It also highlights the importance of the novel method of using chemoprophylaxis for control of an ongoing outbreak of CAP. (Source: Medical Journal Armed Forces India)
Source: Medical Journal Armed Forces India - November 22, 2014 Category: Journals (General) Source Type: research

Short- and long-term effects of a physical activity counselling programme in COPD: A randomized controlled trial
We were interested in the effects of a physical activity (PA) counselling programme in three groups of COPD patients from general practice (primary care), outpatient clinic (secondary care) and pulmonary rehabilitation (PR). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - November 22, 2014 Category: Respiratory Medicine Authors: Wytske A. Altenburg, Nick H.T. ten Hacken, Linda Bossenbroek, Huib A.M. Kerstjens, Mathieu H.G. de Greef, Johan B. Wempe Tags: Clinical Trial Paper Source Type: research

Value of the DECAF score in predicting hospital mortality in patients with acute exacerbation of chronic obstructive pulmonary disease admitted to Zagazig University Hospitals, Egypt
Conclusion The DECAF Score is a simple and effective clinical tool that can risk stratify hospitalized patients with AECOPD and could therefore help clinicians managing this fatal condition. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - November 22, 2014 Category: Respiratory Medicine Source Type: research

Dramatic and sustained responsiveness of pulmonary Langerhans cell histiocytosis-associated pulmonary hypertension to vasodilator therapy
We describe a PLCH patient severe, disease-related PH that responded unexpectedly well to advanced PH therapy with sustained improvement over a 10 year follow-up period. This case indicates that PLCH associated PH may, in certain instances, be highly responsive to advanced PH therapies and emphasizes the importance of trialing these therapies among patients with PLCH-related PH. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - November 22, 2014 Category: Respiratory Medicine Source Type: research

Improvement in idiopathic nonspecific interstitial pneumonia after smoking cessation
Publication date: Available online 22 November 2014 Source:Respiratory Medicine Case Reports Author(s): Tsutomu Shinohara , Naoki Kadota , Hiroyuki Hino , Keishi Naruse , Yuji Ohtsuki , Fumitaka Ogushi Although cigarette smoking has been recognized as a risk factor for the development of several interstitial lung diseases, the relationship between smoking and nonspecific interstitial pneumonia (NSIP) has not yet been fully elucidated. We here present a case of fibrotic NSIP with mild emphysema in an elderly male with normal pulmonary function, whose symptoms, serum KL-6 level, and high-resolution computed tomography find...
Source: Respiratory Medicine Case Reports - November 22, 2014 Category: Respiratory Medicine Source Type: research

Development of a tool to recognize small airways dysfunction in asthma (SADT)
Conclusions: The first step of the development of the SADT tool shows that there are relevant differences in signs and respiratory symptoms between asthma patients with and without SAD. The next step is to test and validate all items in order to retain the most relevant items to create a short and simple tool, which should be useful to identify asthma patients with SAD in clinical practice. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - November 22, 2014 Category: Global & Universal Authors: Lieke Schiphof-GodartErica van der WielNick ten HackenMaarten van den BergeDirkje PostmaThys van der Molen Source Type: research

Molecular characterization of H3N2 influenza A viruses isolated from Ontario swine in 2011 and 2012
Conclusions: The characterization of the Ontario H3N2 viruses clearly indicates reassortment of gene segments between the North American swine trH3N2 from cluster IV and the A(H1N1)pdm09 virus. (Source: Virology Journal)
Source: Virology Journal - November 22, 2014 Category: Virology Authors: Helena Grgi¿Marcio CostaRobert FriendshipSusy CarmanÉva NagyGreg WidemanScott WeeseZvonimir Poljak Source Type: research

Bioactive Food Components as Dietary Intervention for Cystic Fibrosis.
Abstract Cystic fibrosis (CF) is a genetic disorder that can lead to death at an early age. CF is characterized by respiratory infection, airway obstruction, inflammation, and eventually end-stage lung failure. CF also damages pancreatic exocrine function resulting in serious complications such as nutritional deficiencies. Current therapy to this multisystem disease requires the practice of both pharmacological and nutritional approaches. Growing evidence shows that bioactive food components, such as polyunsaturated fatty acids, phytochemicals, and antioxidants, have beneficial effects in the management of CF disea...
Source: Current Drug Targets - November 22, 2014 Category: Drugs & Pharmacology Authors: Sirinupong N, Yang Z Tags: Curr Drug Targets Source Type: research

The Prevalence of COPD in Individuals with Acute Coronary Syndrome: A Spirometry-Based Screening Study
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 21, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Sirtuin 1 Activator SRT1720 Protects Against Lung Injury via Reduction of Type II Alveolar Epithelial Cells Apoptosis in Emphysema
COPD: Journal of Chronic Obstructive Pulmonary Disease, Ahead of Print. (Source: COPD: Journal of Chronic Obstructive Pulmonary Disease)
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - November 21, 2014 Category: Respiratory Medicine Tags: article Source Type: research