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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Neonatal metabolic acidosis at birth: In search of a reliable marker.
CONCLUSION: Birth-related neonatal eucapnic pH is described as the most pertinent marker of NMA at birth. The various means of calculating this value and the level below which it seems to play a possible pathogenic role are presented. PMID: 27216950 [PubMed - as supplied by publisher] (Source: Gynecologie Obstetrique Fertilite)
Source: Gynecologie Obstetrique Fertilite - May 26, 2016 Category: OBGYN Tags: Gynecol Obstet Fertil Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Pulmonary Medicine)
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: Editorial Introductions Source Type: research

Advanced bronchoscopic techniques for the diagnosis of peripheral pulmonary lesions
Purpose of review: The review describes recent advances in bronchoscopic modalities used to diagnose peripheral pulmonary lesions. Recent findings: The pooled diagnostic yield and sensitivity of radial probe endobronchial ultrasound (r-EBUS) has been reported to be 56% for lesions less than 2 cm and 78% for lesions more than 2 cm and 73%, respectively. The pooled diagnostic yield and sensitivity of electromagnetic navigational bronchoscopy (ENB) has been reported to be 65 and 71%, respectively. However, significant heterogeneity between studies was evident for both r-EBUS and ENB (sensitivity of r-EBUS: I2 = 75%; ...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

The five commandments of efficient and effective care in the initial evaluation of lung cancer
This article aims to increase awareness among clinicians about the scope of this problem, and provides a simplified primer on the core concepts of how to perform an efficient and effective workup that is in-line with national guidelines. Recent findings: Although the basic principles underlying lung cancer evaluation have not changed in the last decade, there are new areas of debate which are outlined and discussed in this article. These include: the value of brain and bone imaging in asymptomatic patients, the best initial site to biopsy in the era of genomics, and the use of biomarkers with low-dose chest tomography scr...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

Lung cancer screening
Purpose of review: Lung cancer screening with low-dose chest computed tomography is now recommended for high-risk individuals by the US Preventive Services Task Force. This recommendation was informed by several randomized controlled trials, the largest of which, the National Lung Screening Trial, demonstrated a 20% relative reduction in lung cancer mortality with annual low-dose chest computed tomography compared with chest radiography. Recent findings: The benefit of lung cancer screening must be balanced against potential harms, including a high false-positive rate with consequent further evaluative studies and invasiv...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

Chemotherapy in elderly patients with nonsmall cell lung cancer
Purpose of review: Using chemotherapy in elderly nonsmall cell lung cancer (NSCLC) patients is often challenging given concerns of treatment-related toxicity. However, data have demonstrated that chemotherapy can lead to improved survival in this age group. In this review, we summarize existing data and discuss the role of chemotherapy in elderly patients with localized, locally advanced, and metastatic NSCLC. Recent findings: Clear evidence-based guidelines for chemotherapy management in elderly patients is lacking given the limited prospective data available. However, there are more clinical trials investigating optimal...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

Lung cancer in chronic obstructive pulmonary disease patients, it is not just the cigarette smoke
Purpose of review: An important association has been described between chronic obstructive pulmonary disease (COPD) and lung cancer, where different mechanisms have been proposed. There is no unique cause for this association, as COPD is by itself a heterogeneous disease, in which their classical phenotypes (i.e., emphysema and chronic bronchitis) each play an important role in lung cancer development. We will discuss recent evidence that links these two diseases and specific characteristics found in lung cancers from patients with COPD. Recent findings: Molecular studies have found specific gene expressions (reduction an...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: NEOPLASMS OF THE LUNG: Edited by Alan Fein and David E. Ost Source Type: research

Phenotyping malignant pleural effusions
Purpose of review: Patients with malignant pleural effusions (MPEs) are heterogenous in their disease course, symptom severity, responses to cancer therapies, fluid recurrence rates, and thus need for definitive fluid control measures. To tailor the most appropriate treatment for individual patients, clinicians need to ‘phenotype’ the patients and predict their clinical course. This review highlights the recent efforts to develop better predictive tools and knowledge gaps for further research. Recent findings: The LENT scoring system, which includes pleural fluid lactate dehydrogenase, performance status, serum neutro...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Malignant pleural effusions because of lung cancer
Purpose of review: The discovery of a pleural effusion in the setting of lung cancer has diagnostic, prognostic, and therapeutic challenges, some of which are addressed in this review. Recent findings: Around 20% of patients with lung cancer have minimal pleural effusions, which are not amenable to a diagnostic thoracentesis. These patients have a poorer overall survival (∼7.5 months) than those without effusions (∼12–18 months), although slightly better than those with proven malignant fluids (∼5.5 months). Tumor genotype techniques are feasible on pleural fluid specimens and clinically helpful in identifying pat...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Pleural gas analysis for the identification of alveolopleural fistulae
Purpose of review: The method for identification of alveolopleural fistulae (APF) by visual inspection of air bubbles in the chest drainage system has several limitations and suffers from poor accuracy. Here we discuss the use of a novel technique of pleural gas analysis in the identification and management of APF. Recent findings: We found that pleural gas analysis has higher sensitivity and specificity than visual inspection in identifying APF. Additionally, we demonstrated that intrapleural gas milieu impacts lung healing and reduction of intrapleural carbon dioxide can promote resolution of APF. Summary: Pleural gas ...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Pleural fluid tests to diagnose tuberculous pleuritis
This article summarizes current data regarding the accuracy of pleural fluid tests assisting the diagnosis of tuberculous pleuritis (TBP). Recent findings: No pleural fluid test reliably rules-in TBP in settings with low TBP prevalence. Interferon-γ) alone or in combination with adenosine deaminase (ADA) is more reliable than ADA for this purpose in nonlow prevalences. ADA can reliably rule-out TBP in prevalences of less than 40% although in higher prevalences the product of interleukin-27 and ADA is the most accurate rule-out test. Summary: The definite diagnosis of TBP requires the isolation of Mycobacterium tuberculo...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Complications of thoracentesis: incidence, risk factors, and strategies for prevention
Purpose of review: Although thoracentesis is generally considered safe, procedural complications are associated with increased morbidity, mortality, and healthcare costs. In this article, we review the risk factors and prevention of the most common complications of thoracentesis including pneumothorax, bleeding (chest wall hematoma and hemothorax), and re-expansion pulmonary edema. Recent findings: Recent data support the importance of operator expertise and the use of ultrasound in reducing the risk of iatrogenic pneumothorax. Although coagulopathy or thrombocytopenia and the use of anticoagulant or antiplatelet medicati...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Pleural effusions as markers of mortality and disease severity: a state-of-the-art review
Purpose of review: Pleural effusions are common and are the result of various etiologies. Malignant pleural effusion (MPE) has a known high mortality, but there is also increasing evidence that patients with benign pleural effusions also have a poor prognosis. This review will discuss the most recent literature on mortality and prognostication in patients with pleural effusion. Recent findings: Survival in patients with MPE is influenced by many factors, the most significant of which are underlying tumor type, performance score, and markers of systemic inflammation. Prognostic models have been developed for patients with ...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Pleural biopsies in undiagnosed pleural effusions; Abrams vs image-guided vs thoracoscopic biopsies
This article will review recent research relating to these methods, aiming to provide an overview of the strengths and limitations of each technique. Recent findings: Historically pleural biopsies were undertaken using a blind closed ‘Abrams’ needle method. However, low diagnostic yields and high complication rates are seen with this technique compared with newer methods. Recent research compares image-guided, cutting-needle approaches to traditional Abrams biopsies, and evaluates the role of medical thoracoscopy in comparison to other techniques. Summary: Thoracoscopic biopsies are the gold standard for investigatin...
Source: Current Opinion in Pulmonary Medicine - May 26, 2016 Category: Respiratory Medicine Tags: DISEASES OF THE PLEURA: Edited by Richard Light Source Type: research

Dieulafoy's disease of the airways: a comprehensive review of a rare entity
This article is protected by copyright. All rights reserved. (Source: Histopathology)
Source: Histopathology - May 26, 2016 Category: Pathology Authors: Patrizia Viola, Irene Amat Villegas, Michael Dusmet, Andrew Gordon Nicholson, Maria Angeles Montero Fernandez Tags: Correspondence Source Type: research

Screening for cardiac and respiratory problems in elite sport - compare and contrast.
Authors: Hull JH, Rawlins JC PMID: 27217059 [PubMed - as supplied by publisher] (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - May 26, 2016 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

Therapeutic effect of budesonide/formoterol, montelukast and N-acetylcysteine for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation
This study inv... (Source: Respiratory Research)
Source: Respiratory Research - May 26, 2016 Category: Respiratory Medicine Authors: Sei Won Kim, Chin Kook Rhee, Yoo Jin Kim, Seok Lee, Hee Je Kim and Jong Wook Lee Source Type: research

Dynamic comparison of pharyngeal stability during sleep in patients with obstructive sleep apnea syndrome treated with maxillomandibular advancement
Conclusions MMA promoted an important increase of the pharynx during induced sleep and a more significant change in the variability of its lumen. With a lower variation in the diameter of the organ during the respiratory movements, there is greater airway stability and a consequent maintenance of the pharyngeal lumen that reduces or even prevents pharyngeal collapse. (Source: Sleep and Breathing)
Source: Sleep and Breathing - May 26, 2016 Category: Respiratory Medicine Source Type: research

Disseminated cryptococcosis presenting as mediastinal and hilar lymphadenopathy in an immunocompetent patient
Abstract We herein report a rare case of disseminated cryptococcosis presenting as mediastinal and hilar lymphadenopathy in a young immunocompetent man. A previously healthy 26‐year‐old man presented with persistent headache and nonproductive cough. Chest computed tomography indicated mediastinal and hilar lymphadenopathy. Cryptococcal lymphadenitis and meningitis was confirmed by endobronchial ultrasound‐guided transbronchial needle aspiration and central spinal fluid examination, respectively. He received liposomal amphotericin B and flucytosine followed by fluconazole and finally improved. We encountered a rare c...
Source: Respirology Case Reports - May 26, 2016 Category: Respiratory Medicine Authors: Yasushi Murakami, Masahide Oki, Hideo Saka, Shigehisa Kajikawa, Ayuka Murakami, Akane Ishida Tags: Case Report Source Type: research

Functions of the placenta
Publication date: Available online 25 May 2016 Source:Anaesthesia & Intensive Care Medicine Author(s): Leo Donnelly, Gillian Campling The placenta is an ephemeral materno-fetal organ with chorionic (fetal) villi bathed in maternal blood spaces, which allows restricted transfer of metabolites and drugs across specialized transfer areas. The placenta develops respiratory, nutritive and excretory functions while the fetal organs mature, and is also an important endocrine organ. (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - May 26, 2016 Category: Anesthesiology Source Type: research

Sedation in children undergoing magnetic resonance imaging comparative study between dexmedetomidine and ketamine
Conclusion Dexmedetomidine provided adequate sedation in most of the children without hemodynamic or respiratory embarrassment, in comparison with ketamine which provided adequate sedation but with delayed discharge time and more side effects. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - May 26, 2016 Category: Anesthesiology Source Type: research

Transcatheter Patent Ductus Arteriosus Occlusion in Small Infants
ConclusionsIn our cohort of symptomatic infants, transcatheter PDA occlusion was successful in most and a ratio of minimum PDA diameter/length of <0.4 was predictive of technical success. Using a surrogate for pulmonary support, the majority of patients were on less support 7 days after closure. (Source: Congenital Heart Disease)
Source: Congenital Heart Disease - May 26, 2016 Category: Cardiology Authors: Matthew C. Schwartz, David Nykanen, Lawrence H. Winner, Jose Perez, Michael McMahan, Hamish M. Munro, Sukumar Suguna Narasimhulu Tags: Original Article Source Type: research

Organic cation rhodamines for screening organic cation transporters in early stages of drug development
Publication date: Available online 26 May 2016 Source:Journal of Pharmacological and Toxicological Methods Author(s): Malachy C. Ugwu, Angus Oli, Charles O. Esimone, Remigius U. Agu The aim of this study was to investigate the suitability of rhodamine-123, rhodamine-6G and rhodamine B as non-radioactive probes for characterizing organic cation transporters in respiratory cells. Fluorescent characteristics of the compounds were validated under standard in vitro drug transport conditions (buffers, pH, and light). Uptake/transport kinetics and intracellular accumulation of the compounds were investigated. Uptake/transpo...
Source: Journal of Pharmacological and Toxicological Methods - May 26, 2016 Category: Drugs & Pharmacology Source Type: research

A case of a chlorine inhalation injury in an Ebola treatment unit
We present a 26-year-old male British military nurse, deployed to Sierra Leone to treat patients with Ebola virus disease at the military-run Kerry Town Ebola Treatment Unit. Following exposure to chlorine gas during routine maintenance procedures, the patient had an episode of respiratory distress and briefly lost consciousness after exiting the facility. Diagnoses of reactive airways disease, secondary to the chlorine exposure and a hypocapnic syncopal episode were made. The patient was resuscitated with minimal intervention and complete recovery occurred in less than 1 week. This case highlights the issues of using...
Source: Journal of the Royal Army Medical Corps - May 26, 2016 Category: Journals (General) Authors: Carpenter, A., Cox, A. T., Marion, D., Phillips, A., Ewington, I. Tags: Infectious diseases, Nursing Case report Source Type: research

Does continuous positive airway pressure for extubation in congenital tracheoesophageal fistula increase the risk of anastomotic leak? A retrospective cohort study
ConclusionThe use of CPAP in the immediate post‐extubation period after corrective surgery for TEF/EA appears to be safe and may not be associated with increased risk of AL or recurrence of the fistula. Information from other centres, surveys and large databases is needed to define the benefits and risks of use of CPAP in these infants. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - May 26, 2016 Category: Pediatrics Authors: Piyush S Shah, Parshotam Gera, Ian J Gollow, Shripada C Rao Tags: Original Article Source Type: research

An innovative COPD early detection programme in general practice: evaluating barriers to implementation
npj Primary Care Respiratory Medicine, Published online: 26 May 2016; doi:10.1038/npjpcrm.2016.29 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - May 26, 2016 Category: Primary Care Authors: Joseph AM DirvenAlbine MoserHuibert J TangeJean WM MurisOnno CP van Schayck Source Type: research

Content and quality of websites supporting self-management of chronic breathlessness in advanced illness: a systematic review
npj Primary Care Respiratory Medicine, Published online: 26 May 2016; doi:10.1038/npjpcrm.2016.25 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - May 26, 2016 Category: Primary Care Authors: Tim LuckettRebecca DislerAnnmarie HosieMiriam JohnsonPatricia DavidsonDavid CurrowAnthony SumahJane Phillips Source Type: research

Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT)
npj Primary Care Respiratory Medicine, Published online: 26 May 2016; doi:10.1038/npjpcrm.2016.28 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - May 26, 2016 Category: Primary Care Authors: Mark L LevyPNR DekhuijzenPJ BarnesM BroedersCJ CorriganBL ChawesL CorbettaJC DubusTh HausenF LavoriniN RocheJ SanchisOmar S UsmaniJ ViejoW VinckenTh VoshaarGK CromptonSoren Pedersen Source Type: research

IL‐10 gene polymorphism is associated with preschool atopy and early‐life recurrent wheezing after bronchiolitis in infancy
ConclusionsIL‐10 polymorphisms at rs1800871, rs1800872, rs1800890, and rs1800896 seem to be associated with elevated allergies and/or recurrent wheezing risk in later childhood, after early‐life bronchiolitis. Pediatr Pulmonol. 2016; 9999:XX–XX. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 26, 2016 Category: Respiratory Medicine Authors: Matti Korppi, Kirsi Nuolivirta, Eero Lauhkonen, Annukka Holster, Johanna Teräsjärvi, Juho Vuononvirta, Merja Helminen, Qiushui He, Petri Koponen Tags: Original Article: Asthma Source Type: research

Bronchiolitis: Analysis of 10 consecutive epidemic seasons
Summary Bronchiolitis is the leading cause of hospitalization in infants under 12 months. Our aims were to analyze epidemiological characteristics of infants with bronchiolitis over 10 consecutive seasons and to evaluate whether there are any clinical differences between infants hospitalized for bronchiolitis during epidemic peak months and infants in non‐peak months. We enrolled consecutive enrolled 723 previously healthy term infants hospitalized at the Paediatric Emergency Department, “Sapienza” University of Rome over the period 2004–2014. Fourteen respiratory viruses were detected from nasopharyngeal aspirates...
Source: Pediatric Pulmonology - May 26, 2016 Category: Respiratory Medicine Authors: Giulia Cangiano, Raffaella Nenna, Antonella Frassanito, Melania Evangelisti, Ambra Nicolai, Carolina Scagnolari, Alessandra Pierangeli, Guido Antonelli, Paola Papoff, Laura Petrarca, Paolo Capocaccia, Corrado Moretti, Fabio Midulla Tags: Original Article Source Type: research

The burden of community‐managed acute respiratory infections in the first 2‐years of life
ConclusionsARIs are a common cause of morbidity in the first 2‐years of life, with children experiencing 13 discrete ARI episodes and almost 5‐months of respiratory symptoms. Most ARIs are managed in the community by parents and family physicians. Antibiotic prescribing remains common for ARIs in young children. Secular societal changes, including greater use of childcare in early childhood, may have maintained the high ARI incidence in this age‐group. Pediatr Pulmonol. 2016; 9999:XX–XX. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 26, 2016 Category: Respiratory Medicine Authors: Mohinder Sarna, Robert S. Ware, Theo P. Sloots, Michael D. Nissen, Keith Grimwood, Stephen B. Lambert Tags: Original Article Source Type: research

Cardiopulmonary exercise performance is reduced in congenital diaphragmatic hernia survivors
ConclusionMore than half of CDH survivors continue to have chronic pulmonary disease. CDH survivors had lower aerobic exercise capacity than controls. Self‐reporting information on daily activities may identify CDH patients with low who may benefit from physical training. Pediatr Pulmonol.. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 26, 2016 Category: Respiratory Medicine Authors: Katarina Bojanić, Ruža Grizelj, Daniel Dilber, Dalibor Šarić, Jurica Vuković, Paolo T. Pianosi, David J. Driscoll, Toby N. Weingarten, Ena Pritišanac, Darrell R. Schroeder, Juraj Sprung Tags: Original Article Source Type: research

Accuracy of clinical swallowing evaluation for diagnosis of dysphagia in children with laryngomalacia or glossoptosis
ConclusionsDysphagia was highly prevalent in this sample. The sensitivity of clinical evaluation to detect laryngeal penetration and tracheal aspiration was low, as the majority of aspiration events were silent. The videofluoroscopic study is important in order to determine a safest method to feed the patient. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 26, 2016 Category: Respiratory Medicine Authors: Marisa Gasparin, Cláudia Schweiger, Denise Manica, Antônio Carlos Maciel, Gabriel Kuhl, Deborah Salle Levy, Paulo José Cauduro Marostica Tags: Original Article Source Type: research

Blunted blood pressure response during hyperpnoea in endurance runners
Publication date: August 2016 Source:Respiratory Physiology &amp; Neurobiology, Volume 230 Author(s): Yuka Itoh, Keisho Katayama, Erika Iwamoto, Kazushige Goto, Yasuhiro Suzuki, Toshiyuki Ohya, Kenji Takao, Koji Ishida The purpose of this study was to elucidate the cardiovascular response during hyperpnoea in endurance-trained runners compared to sedentary controls. Twelve runners and ten sedentary individuals participated in this study. A maximal respiratory endurance test (MRET) was performed as follows: target minute ventilation was initially set at 30% of maximal voluntary ventilation (MVV12) and was incr...
Source: Respiratory Physiology and Neurobiology - May 26, 2016 Category: Respiratory Medicine Source Type: research

The hypometabolic response to repeated or prolonged hypoxic episodes in the chicken embryo
Publication date: August 2016 Source:Respiratory Physiology &amp; Neurobiology, Volume 230 Author(s): Ryoji Ide, Satoko Tomita Ide, Jacopo P. Mortola Hypoxia (hx) in embryos causes a drop in oxygen consumption ( V ˙ O 2 ) that rapidly recovers upon return to normoxia. We asked whether or not this pattern varies with the embryo's hypoxic history. The V ˙ O 2 of chicken embryos in the middle (E12) or at end-incubation (E19) was measured by an open-flow methodology during 15-min epochs of moderate (15% O2) or severe hx (10% O2). Each hx-epoch was repeated or alternated with air by various modalities (ai...
Source: Respiratory Physiology and Neurobiology - May 26, 2016 Category: Respiratory Medicine Source Type: research

Changes in vagal afferent drive alter tracheobronchial coughing in anesthetized cats
Publication date: August 2016 Source:Respiratory Physiology &amp; Neurobiology, Volume 230 Author(s): Michal Simera, Ivan Poliacek, Marcel Veternik, Lucia Babalova, Zuzana Kotmanova, Jan Jakus Unilateral cooling of the vagus nerve (&lt;5°C, blocking mainly conductivity of myelinated fibers) and unilateral vagotomy were employed to reduce cough afferent drive in order to evaluate the effects of these interventions on the temporal features of the cough reflex. Twenty pentobarbitone anesthetized, spontaneously breathing cats were used. Cough was induced by mechanical stimulation of the tracheobronchial airway...
Source: Respiratory Physiology and Neurobiology - May 26, 2016 Category: Respiratory Medicine Source Type: research

Interleukin-1β and interleukin-6 enhance thermal prolongation of the LCR in decerebrate piglets
We examined the effects of intraperitoneal (I.P.) injections of 0.3mg/Kg IL-1β with or without I.P. 10mg/Kg indomethacin pretreatment on the duration of the LCR, and in the same animals we also examined the duration of the LCR when body temperature was elevated approximately 2°C. We found that IL-1β significantly increased the duration of the LCR even when body temperature was held constant. There was a significant multiplicative effect when elevated body temperature was combined with IL-1β treatment: prolongation of the LCR was significantly greater than the sum of independent thermal and IL-1β-induced prolongations ...
Source: Respiratory Physiology and Neurobiology - May 26, 2016 Category: Respiratory Medicine Source Type: research

Diffuse Alveolar Hemorrhage Secondary to Antineutrophil Cytoplasmic Antibody–Associated Vasculitis: Predictors of Respiratory Failure and Clinical Outcomes
ConclusionOur findings indicate that the most important predictor of respiratory failure in patients with DAH secondary to AAV is the degree of hypoxemia upon presentation. No clear benefit of the addition of PE to standard remission induction therapy was demonstrated. Complete remission by 6 months was achieved at a higher rate with rituximab than with cyclophosphamide in patients with DAH secondary to AAV, including those needing mechanical ventilation. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - May 26, 2016 Category: Rheumatology Authors: Rodrigo Cartin‐Ceba, Luis Diaz‐Caballero, Mazen O. Al‐Qadi, Stavros Tryfon, Fernando C. Fervenza, Steven R. Ytterberg, Ulrich Specks Tags: Vasculitis Source Type: research

Alkaline phosphatase activity in airway fluid obtained by tracheal wash from adult horses
ConclusionsDetermining tracheal wash ALP activity is a simple, inexpensive and safe technique that can be used to facilitate the early diagnosis of equine respiratory disease, since it is higher in asymptomatic adult horses with a TW cytology profile consistent with LRT inflammation than in healthy adult horses with a normal TW cytology profile. (Source: Veterinary Clinical Pathology)
Source: Veterinary Clinical Pathology - May 26, 2016 Category: Veterinary Research Authors: Vanessa Viscardi, Maria Luisa L. A. Jorge, Katia M. Silva, Eliene P. Sad, Ana Beatriz M. Fonseca, Nayro X. Alencar, Daniel Augusto B. Lessa Tags: Original Research Source Type: research