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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Improvements in Sleep and Handwriting after Complementary Medical Intervention using Acupuncture, Applied Kinesiology, and Respiratory Exercises in a Nine-Year-Old ADHD Patient on Methylphenidate
Publication date: November–December 2014 Source:EXPLORE: The Journal of Science and Healing, Volume 10, Issue 6 Author(s): Friedrich Molsberger , Christa Raak , Christiane Witthinrich The case study reports on the effect of pharmacological, complementary, and alternative medicine including acupuncture, Applied Kinesiology, and respiratory exercises in a boy with attention-deficit hyperactivity disorder (ADHD) on methylphenidate. A nine-year-old male patient was referred to treatment with a three-year diagnosis of ADHD, sleeping troubles, and dissatisfaction with methylphenidate. Examination included Applied Kinesiology...
Source: EXPLORE: The Journal of Science and Healing - January 25, 2015 Category: Complementary Medicine Source Type: research

Cycloserine induced delirium during treatment of multi-drug resistant tuberculosis (MDR-TB)
Conclusion Patients with MDR-TB receiving Cycloserine should be closely monitored for neuropsychiatric side effects for early recognition and treatment. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - January 25, 2015 Category: Respiratory Medicine Source Type: research

Comparison of hospitalization among German coastal and deep sea fishermen
Conclusions Fishery is still an occupation which poses a high risk for malignant neoplasms and injuries. This is likely due to lifestyle and work-related factors. Further studies are needed to evaluate the different working and living conditions of coastal and deep sea fishermen. (Source: International Archives of Occupational and Environmental Health)
Source: International Archives of Occupational and Environmental Health - January 25, 2015 Category: Occupational Health Source Type: research

Rotenone exerts similar stimulatory effects on H2O2 production by isolated brain mitochondria from young–adult and old rats
Publication date: 4 March 2015 Source:Neuroscience Letters, Volume 589 Author(s): Luiz G.B. Michelini , Tiago R. Figueira , Edilene S. Siqueira-Santos , Roger F. Castilho Chronic and systemic treatment of rodents with rotenone, a classical inhibitor of mitochondrial respiratory complex I, results in neurochemical, behavioral, and neuropathological features of Parkinson’s disease. The aim of the present study was to evaluate whether brain mitochondria from old rats (24 months old) would be more susceptible to rotenone-induced inhibition of oxygen consumption and increased generation of H2O2 than mitochondria from young...
Source: Neuroscience Letters - January 25, 2015 Category: Neuroscience Source Type: research

Management of Critical Asthma Syndrome During Pregnancy
Abstract One-third of pregnant asthmatics experience a worsening of their asthma that may progress to a critical asthma syndrome (CAS) that includes status asthmaticus (SA) and near-fatal asthma (NFA). Patients with severe asthma before pregnancy may experience more exacerbations, especially during late pregnancy. Prevention of the CAS includes excellent asthma control involving targeted early and regular medical care of the pregnant asthmatic, together with medication compliance. Spontaneous abortion risk is higher in pregnant women with uncontrolled asthma than in non-asthmatics. Should CAS occur during pregnan...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Infection in Severe Asthma Exacerbations and Critical Asthma Syndrome
Abstract In chronic persistent asthma and severe acute exacerbations of bronchial asthma, infectious agents are the predominant triggers that drive disease and airway pathobiology. In acute exacerbations of bronchial asthma (AEBA) including near fatal and fatal asthma, viral agents, particularly human rhinovirus-C, respiratory syncytial virus and influenza A appear to be the more prevalent and recurring threats. Both viral, and to a lesser extent bacterial agents, can play a role, and co-infection may also be present and worsen prognosis in hospitalized patients, placing a portion at risk for critical asthma synd...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Immunobiology of Critical Pediatric Asthma
Abstract Asthma is a heterogeneous disease with numerous clinical phenotypes. Severe asthma constitutes about 10 % of all cases of asthma. There is significant geographic and regional variation in the incidence and severity of asthma. Other important factors include gender, ethnicity, living environment, lifestyle, socioeconomic class, and pathophysiology. These factors can often be identified as either genetic or environmental influences on asthma severity. The immune system derangements in severe asthma are poorly understood. Many molecules and cell types have been implicated in severe asthma, including neutro...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Definition of Critical Asthma Syndromes
Abstract Urgent visits to the clinic and emergency department for acute severe asthma exacerbations are all too frequent. Existing national guidelines do not present consistent or specific recommendations for the evaluation and treatment of individual asthma patients in respiratory distress. In this vein, we propose the term "critical asthma syndrome" (CAS) to describe any child or adult who is at high risk for fatal asthma. Acute severe asthma, refractory asthma, status asthmaticus, and near-fatal asthma all describe CAS where physical exhaustion from the overwhelming work of breathing leads to respira...
Source: Clinical Reviews in Allergy and Immunology - January 24, 2015 Category: Allergy & Immunology Source Type: research

Do all asthmatic patients have the same disease?
In this study, lung functional impairment was identified in infancy but was not accompanied by substantial airway pathology at tissue examination. The likelihood and severity of clinical asthma occurring during the follow-up period correlated with lung function at infancy but not with any pathologic finding. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2015 Category: Allergy & Immunology Authors: Marc H. Lavietes Tags: Guest editorial Source Type: research

Syncope as a manifestation of mast cell activation disorder
Anaphylaxis is a potentially fatal systemic allergic reaction that results from the abrupt release of basophil and mast cell mediators, such as histamine and tryptase. The clinical manifestations include skin, respiratory, and cardiovascular symptoms; however, a rapid decrease in blood pressure may be the unique manifestation. The most frequent causes of anaphylaxis are Hymenoptera venom, foods, and drugs.1 Idiopathic anaphylaxis is considered in case of unknown cause.2 (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - January 24, 2015 Category: Allergy & Immunology Authors: Carolina Perales Chordá, Sandra Fabregat Nebot, Pedro Moral Moral, Isidro Jarque Ramos, Dolores Hernández Fernandez de Rojas Tags: Letter Source Type: research

Risk of adverse events among older adults following co-prescription of clarithromycin and statins notmetabolized by cytochrome P450 3A4.
 Among older adults taking a statin not metabolized by CYP3A4 (rosuvastatin/pravastatin/fluvastatin), co-prescription of clarithromycin versus azithromycin was associated with a modest but statistically significant increase in the 30-day absolute risk of adverse outcomes, including AKI and admission with hyperkalemia. : Treatment of Kidney Transplant Recipients With ACEi/ARB and Risk of Respiratory Tract Cancer: A Collaborative Transplant Study Report Novartis announces termination of ALTITUDE study Effects of Intensive Blood-Pressure Control in Type 2 Diabetes Mellitus (Source: Nephrology Now)
Source: Nephrology Now - January 24, 2015 Category: Urology & Nephrology Authors: Nephrology Now editors Tags: Acute Kidney Injury Internal Medicine for Nephrologists Source Type: research

Exercise Training for Management of Peripheral Arterial Disease: A Systematic Review and Meta-Analysis
Conclusions and relevance Exercise training improves cardio-respiratory fitness, pain-free and total flat-ground walking distances, as well as graded treadmill performance in PAD. Exercise prescriptions for PAD may consider arm cranking as well as lower limb exercise, possibly at short vigorous intensity intervals, but only to a threshold of mild pain. (Source: Sports Medicine)
Source: Sports Medicine - January 24, 2015 Category: Sports Medicine Source Type: research

Respiratory Virus (RV) from Broncho Alveolar Lavage (BAL) Prior to Hematopoietic Cell Transplantation (HCT): A Strong Predictor for Allo-Immune Mediated Lung Syndromes (allo-LS)
This study evaluates the impact of RV RNA-DNA-positivity pre-HCT from NPA or BAL respectively on the occurrence of allo-LS. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Birgitta Versluys, Marc Bierings, Caroline A. Lindemans, Kors Ent vd, Tom Wolfs, Jean Luc Murk, Jaap-Jan Boelens Tags: GVH/GVL Source Type: research

Human Metapneumovirus Infections in Hematopoietic Cell Transplant Recipients: Seasonality and Factors Associated with Progression to Lower Respiratory Tract Disease
Human metapneumovirus (HMPV) is a respiratory virus that was first identified in 2001. In immunocompromised hosts, HMPV upper respiratory tract infection (URI) can progress to lower respiratory tract disease (LRD). The mortality rate after HMPV LRD in hematopoietic cell transplant (HCT) recipients is as high as 40%, similar to that of respiratory syncytial virus, a structurally similar respiratory virus. To date, most studies in HCT recipients are of very small sample size, and minimal data exists on risk factors for LRD. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Sachiko Seo, Ted Gooley, Jane M. Kuypers, Zach Stednick, Keith R. Jerome, Janet A. Englund, Michael J. Boeckh Tags: Supportive Care Source Type: research

Oral Ribavirin for the Treatment of Respiratory Syncytial Virus Infection in Allogeneic Stem Cell Transplant Recipients-Utility of the Immunodeficiency Scoring Index for Risk Stratification
Respiratory syncytial virus (RSV) infection is a serious complication post allogeneic stem cell transplant. Aerosolized ribavirin is a commonly used therapy; however, oral ribavirin is an alternative with many advantages. There is paucity in literature regarding treatment outcomes using the oral form. Recently, the immunodeficiency scoring index (ISI) was derived from the largest reported RSV cohort to date using aerosolized ribavirin. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Moussab Damlaj, Gabriel Bartoo, Desire Gijima, Shahrukh Hashmi, Mark R. Litzow, William Hogan, Mrinal Patnaik Tags: Late Effects/Quality of Life/Psychosocial Issues Source Type: research

Good Outcome of RSV Infection without Ribavirin Treatment in Pediatric Bone Marrow Transplantation
Clinicians commonly use inhaled ribavirin to treat HSCT recipients with Respiratory Syncytial Virus (RSV); however, limited data exist to support this therapy. We evaluated 349 consecutive patients transplanted between June, 2008 and December, 2013. Eighteen (5.2%) pediatric and young adult patients (6 months to 25 years of age) developed an RSV infection. Fifteen (83%) patients presented with an upper respiratory tract infection (URTI) identified a median of 151 (range 3 – 621) days post-HSCT and 3 (17%) presented with, or progressed to, a lower respiratory tract infection (LRTI) identified a median of 33 (range 10 – ...
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Javier El-Bietar, Adam Stuart Nelson, Gregory Wallace, Christopher E. Dandoy, Sonata Jodele, Kasiani C. Myers, Stella M. Davies, Lara Danziger-Isakov Tags: Pediatric Disorders Source Type: research

Forced Deflation PFT: A Novel Method to Evaluate Lung Function in Infants and Young Children
We describe use of forced deflation PFT (dPFT), a novel technique for assessment of lung function in a series of infants and young children and those unable to perform cooperative testing. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Rakesh K. Goyal, Azada Ibrahimova, Maria L. Escolar, Paul Szabolcs, Mark Vander Lugt, Randy M. Windreich, Daniel J. Weiner Tags: Pediatric Disorders Source Type: research

Trend, Risk Factors and Outcome of Respiratory Syncytial Viral Infection in Pediatric Hematopoietic Stem Cell Transplant Recipients: A Multi-Institutional Review
Respiratory syncytial virus (RSV) is a common cause of serious respiratory infections in hematopoietic stem-cell transplant (HSCT) recipients. Infection of the upper airways may progress to lower airway leading to mortality especially in young children. In spite of being a common infection, there is paucity of data about its prevalence, efficacy of prevention, risk factors for infection and mortality in pediatric HSCT recipients. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Ram Kalpatthi, Matt Hall, Nazia Tabassum, Nancy Shreve, Leigh Casey, Jignesh Dalal Tags: Pediatric Disorders Source Type: research

Late Onset Pulmonary Arterial Hypertension after Successful HSCT for Familial HLH
We report a case of occult pulmonary hypertension that developed 3 years after HSCT for FHLH. The patient was born at 28 weeks with a NICU course consisting of mild respiratory distress syndrome and unilateral grade II intraventricular hemorrhage. At 2.5 months of age, he developed fevers, splenomegaly, progressive pancytopenia, hypofibrinogenemia, hyperferritinemia, and bone marrow hemophagocytosis. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Andrea R. Whitfield, Michael Caplan, Ryan Butts, Susan E. Presnell, Michelle Hudspeth Tags: Pediatric Disorders Source Type: research

Incidence and Outcome of Rhinovirus in Children Undergoing Hematopoietic Stem Cell Transplantation
Human rhinovirus (HRV) is well known to cause upper or lower respiratory tract infection (URTI/LRTI) and is associated with increased morbidity and mortality in immunocompromised adults such as those with cancer or those undergoing hematopoietic stem cell transplantation (HSCT). Asymptomatic children who are about to undergo HSCT with a positive respiratory viral panel (RVP) pose a special challenge and create a dilemma for providers when deciding whether to move forward with HSCT in patients with active viral disease. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: James DeMasi, Victor Aquino, Tiffany Simms-Waldrip, Andrew Young Koh, Sharon Holmes Tags: Supportive Care Source Type: research

Determinants of Physical Activity Levels in Allogeneic Hematopoietic Stem Cell Transplantation Recipients
Respiratory and skeletal muscle strength and submaximal exercise capacity and physical activity levels are known to be reduced in a significant percentage of patients prior to hematopoietic stem cell transplantation (HSCT). However, determinants of physical activity levels of HSCT recipients have not been investigated so far. The aim of this study was to determine the role of physical activity levels in HSCT recipients. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Gulsan Turkoz Sucak, Meral Bosnak Guclu, Zeynep Aribas, Gulsah Bargi, Elif Sakizli, Sahika Zeynep Aki, Zeynep Arzu Yegin Tags: Supportive Care Source Type: research

Identification of Respiratory Viral Infection in Hematopoietic Stem Cell Transplant Recipients - Impact on Non Relapse Mortality
Infection is the leading cause of non-relapse mortality (NRM) in allo-HSCT. A community respiratory virus infection (RVI) screening program was instituted at our center from 5/2010 in order to prevent nosocomial infection, assist in cohorting strategies and minimize RV during allo-HSCT. The impact of RVI screening on respiratory-related NRM was assessed. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Louise Imlay-Gillespie, Meera Srinivasan, Kelly Wong, Christopher Arthur, Keith Fay, Ian Kerridge, William Stevenson, Matthew Greenwood Tags: Allogeneic Transplants Source Type: research

Viral Load in Hematopoietic Cell Transplant Recipients Infected with Human Rhinovirus Correlates with Burden of Symptoms
Human rhinovirus (HRV), the virus predominantly associated with the common cold, is the most common virus detected from respiratory specimens in hematopoietic cell transplant (HCT) recipients, largely due to the development of new sensitive molecular viral detection techniques. In immunocompetent children, HRV viral load from nasal specimens correlates with disease severity, namely the development of pneumonia, hospital admission, and oxygen requirement. Prospective studies describing the relationship between viral load and symptoms in immunocompromised hosts, however, are limited. (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Alpana Waghmare, Jane M. Kuypers, Hu Xie, Wendy Leisenring, Angela P. Campbell, Keith R. Jerome, Janet A. Englund, Michael J. Boeckh Tags: Allogeneic Transplants Source Type: research

Utility of Corticosteroids As Adjunct Therapy for Respiratory Syncytial Virus Infection in Allogeneic Stem Cell Transplant Recipients
Respiratory syncytial virus (RSV) infection causes significant morbidity and mortality in allogeneic stem cell transplant (HCT) recipients. Although ribavirin and immunoglobulin are key components of therapy, the role of adjunct corticosteroids is not established. Corticosteroids may mitigate adverse pulmonary sequelae of RSV infection, although they may also delay viral clearance, and corticosteroid use has been included as a negative factor in recent risk predictors of RSV mortality (RSV ISI-Blood 2014). (Source: Biology of Blood and Marrow Transplantation)
Source: Biology of Blood and Marrow Transplantation - January 24, 2015 Category: Hematology Authors: Gabriel Bartoo, Moussab Damlaj, Desire Gijima, Julianna Merten, Shahrukh Hashmi, Mark R. Litzow, Dennis A. Gastineau, William Hogan, Mrinal Patnaik Tags: Pharmacy Source Type: research

Hypotension in the First Week of Acute Pancreatitis and APACHE II Score Predict Development of Infected Pancreatic Necrosis
Conclusion Hypotension in the first week of AP and APACHE II score predict development of IN. (Source: Digestive Diseases and Sciences)
Source: Digestive Diseases and Sciences - January 24, 2015 Category: Gastroenterology Source Type: research

A Study on Olfactory Dysfunction in Turkish Population with using Survey Method and Validated Olfactory Testing
Abstract The aim of this study was to evaluate the effect of olfactory dysfunction on quality of life (QOL), and to investigate olfactory dysfunction related self-reported clinical features in Turkish population. The participants were questioned about the presence of any olfactory dysfunction. Participants with a complaint of olfactory dysfunction were asked to fill out a survey and then a validated olfactory test was performed. We asked 2,824 volunteers whether they had olfactory dysfunctions or not. A total of 199 (6.7 %) people mentioned that they had, and filled out the questions in our survey. The mean age ...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 24, 2015 Category: ENT & OMF Source Type: research

The Effect of Uvulopalatopharyngoplasty with Tonsillectomy in Patients with Obstructive Sleep Apnea
Abstract In the current study, we evaluated the effectiveness of uvulopalatopharyngoplasty (UPPP) in treatment of patients with obstructive sleep apnea (OSA) syndrome. All patients were previously received medical treatment but their symptoms did not resolve. A prospective study was conducted in Shahid Sadoughi Hospital in Yazd, Iran. Several sleep indices were evaluated using polysomnography (PSG) in all patients before performing UPPP and tonsillectomy. All patients were visited 6 months after surgery and PSG was repeated to assess the efficacy of surgical intervention. A total of 48 patients were enrolled and...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - January 24, 2015 Category: ENT & OMF Source Type: research

Hypertension and Vulnerability to Hemorrhagic Shock in a Rat Model
We present a novel comparative hemorrhage model of shock vulnerability, quantified by “vulnerability curves” expressing physiological response to hemorrhage as a function of three matched shock metrics: cumulative blood volume, mean arterial pressure (MAP), and oxygen delivery (Do2). Responses were central hemodynamics and respiratory and muscle oxygenation obtained for one hypertensive (spontaneously hypertensive [SHR]) and two normotensive (Sprague-Dawley, Wistar-Kyoto) rat strains. Hemorrhagic shock was induced by incremental (0.5 mL) hemorrhage to cardiovascular collapse in anesthetized and mechanically ventilated ...
Source: Shock - January 24, 2015 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Are the obstruction sites visualized on drug-induced sleep endoscopy reliable?
Conclusion DISE could in some cases explain surgical failure. However, it also seems to show additional obstruction sites which do not need to be treated. Proper knowledge of pharyngeal fluid dynamics and mastery of the DISE technique would probably help us understand better some of the DISE findings. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 24, 2015 Category: Respiratory Medicine Source Type: research

Thermal acclimation in the perch (Perca fluviatilis L.) immunity
Publication date: Available online 23 January 2015 Source:Journal of Thermal Biology Author(s): Pertti Marnila , Esa-Matti Lilius Fish immune systems must be able to cope with pathogens over a wide temperature range. Earlier research suggest that fish are more dependent on innate immune responses based on pattern recognition than acquired functions with specific recognition. If this applies to phagocytes, then opsonins (serum factors factors that augment phagocytosis e.g. immunoglobulins and complement proteins) attached on zymosan (Z) particles should be recognized better at higher temperatures than Z only. Z is recogni...
Source: Journal of Thermal Biology - January 24, 2015 Category: Biology Source Type: research

An example of using a decision making framework designed for non-medical prescribers as a method for enhancing prescribing safety for inhaled corticosteroids (ICS)
This report aims to demonstrate the urged need for regulations to maintain a safe non-medical prescribing process. It also adapts the single competency framework provided by the United Kingdom national prescribing centre (NPC, 2012) to be utilised by the respiratory therapist for a safe prescribing process for inhaled corticosteroids (ICS) to control adult asthma as an example. The framework is thought to be an effective tool for safe non-medical prescribing and it is highly recommended to develop a national Saudi framework to maintain the patients’ safety and utilise resources. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - January 24, 2015 Category: Drugs & Pharmacology Source Type: research

Infection With Novel Respiratory Syncytial Virus Genotype Ontario (ON1) in Adult Hematopoietic Cell Transplant Recipients, Texas, 2011-2013
Conclusion This is the first report of RSV ON1 genotype in the United States, and ON1 genotype was dominant genotype in adult HCT recipients. Interestingly, faster viral clearance was associated with a ≥4-fold NAb response, likely indicating a reconstituted immune system. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - January 24, 2015 Category: Infectious Diseases Authors: Avadhanula, V., Chemaly, R. F., Shah, D. P., Ghantoji, S. S., Azzi, J. M., Aideyan, L. O., Mei, M., Piedra, P. A. Tags: VIRUSES Source Type: research

Antibiotic prescribing for respiratory infections: a cross-sectional analysis of the ReCEnT study exploring the habits of early-career doctors in primary care
Conclusion: GP trainee antibiotic prescribing is higher than justified by guidelines. Understanding factors contributing to this pattern will assist in developing educational interventions to improve evidence-based prescribing habits during the early stages of these doctors’ careers. (Source: Family Practice)
Source: Family Practice - January 24, 2015 Category: Primary Care Authors: Dallas, A., Magin, P., Morgan, S., Tapley, A., Henderson, K., Ball, J., Scott, J., Spike, N., McArthur, L., van Driel, M. Tags: Epidemiology Source Type: research

Improved abdominal MRI in non-breath-holding children using a radial k-space sampling technique
Conclusion The radial k-space sampling technique improved the quality and reduced respiratory motion artifacts in young children compared with conventional respiratory-triggered turbo spin-echo sequences. (Source: Pediatric Radiology)
Source: Pediatric Radiology - January 24, 2015 Category: Radiology Source Type: research

Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1ß
Conclusion: Patients with neutrophilic asthma have impairment in anti-inflammatory ratio of gal-3/gal-3BP and IL-1RA/IL-1? which provides a further framework for exploration into pathologic mechanisms of asthma phenotypes. (Source: Respiratory Research)
Source: Respiratory Research - January 24, 2015 Category: Respiratory Medicine Authors: Peng GaoPeter GibsonKatherine BainesIan YangJohn UphamPaul ReynoldsSandra HodgeAlan JamesChristine JenkinsMatthew PetersJie ZhangJodie Simpson Source Type: research

The role of calcium channel blockers for the treatment of pulmonary arterial hypertension: How much do we actually know and how could they be positioned today?
Calcium channel blockers (CCB) were the first vasodilator agents to gain popular acceptance in the treatment of pulmonary arterial hypertension (PAH). They have been shown to be particularly effective in patients who show a significant immediate hemodynamic response to pulmonary vasodilators (“responders”). The application of CCB is currently restricted to “responders” only. It is believed that no more than 5% of PAH patients will benefit from CCB long term. The response rate of most non-idiopathic forms of PAH is considered to be even lower. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 24, 2015 Category: Respiratory Medicine Authors: Boris I. Medarov, Marc A. Judson Tags: Review Source Type: research

Cystic Fibrosis Screen Positive, Inconclusive Diagnosis (CFSPID): A new designation and management recommendations for infants with an inconclusive diagnosis following newborn screening
Newborn screening (NBS) for cystic fibrosis (CF) results in the recognition of a number of infants with a positive NBS result, but an inconclusive diagnosis. Varied practice exists with respect to the management of these infants. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - January 24, 2015 Category: Respiratory Medicine Authors: A. Munck, S.J. Mayell, V. Winters, A. Shawcross, N. Derichs, R. Parad, J. Barben, K.W. Southern Tags: Original Article Source Type: research

Deciphering the Genetic Programme Triggering Timely and Spatially-Regulated Chitin Deposition
by Bernard Moussian, Annalisa Letizia, Guillermo Martínez-Corrales, Bárbara Rotstein, Andreu Casali, Marta Llimargas Organ and tissue formation requires a finely tuned temporal and spatial regulation of differentiation programmes. This is necessary to balance sufficient plasticity to undergo morphogenesis with the acquisition of the mature traits needed for physiological activity. Here we addressed this issue by analysing the deposition of the chitinous extracellular matrix of Drosophila, an essential element of the cuticle (skin) and respiratory system (tracheae) in this insect. Chitin deposition requires the activity ...
Source: PLoS Genetics - January 24, 2015 Category: Genetics & Stem Cells Authors: Bernard Moussian et al. Source Type: research

Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cells
This study investigated the effect of an oxysterol combination of 22(S)-hydroxycholesterol and 20(S)-hydroxycholesterol (SS) on osteogenic differentiation of ESCs and the alterations to mitochondrial activity during differentiation. Osteogenic differentiation was assessed by alkaline phosphatase (ALP) activity, matrix mineralization, mRNA expression of osteogenic factors, runt-related transcription factor 2, osterix, and osteocalcin, and protein levels of collagen type IA (COLIA) and osteopontin (OPN). Treatment of cells with SS increased osteoinductive activity compared to the control group. Intracellular reactive oxygen ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - January 24, 2015 Category: Molecular Biology Source Type: research

Molecular characterization of respiratory syncytial viruses infecting children reported to have received palivizumab immunoprophylaxis
Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections resulting in hospital admission and death among children (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - January 24, 2015 Category: Virology Authors: Danielle B.L. Oliveira, Marika K. Iwane, Mila M. Prill, Geoffrey A. Weinberg, John V. Williams, Marie R. Griffin, Peter G. Szilagyi, Kathryn M. Edwards, Mary A. Staat, Caroline B. Hall, Edison L. Durigon, Dean D. Erdman Source Type: research

Free-breathing T2* mapping using respiratory motion corrected averaging
Conclusions: A free-breathing approach to T2* mapping is demonstrated to produce consistently good quality maps in the presence of respiratory motion and arrhythmias. (Source: Journal of Cardiovascular Magnetic Resonance)
Source: Journal of Cardiovascular Magnetic Resonance - January 24, 2015 Category: Radiology Authors: Peter KellmanHui XueBruce SpottiswoodeChristopher SandinoMichael HansenAmna Abdel-GadirThomas TreibelStefania RosminiChristine ManciniW BandettiniLaura-Ann McGillPeter GatehouseJames MoonDudley PennellAndrew Arai Source Type: research

Diseases of pulmonary surfactant homeostasis.
Abstract Advances in physiology and biochemistry have provided fundamental insights into the role of pulmonary surfactant in the pathogenesis and treatment of preterm infants with respiratory distress syndrome. Identification of the surfactant proteins, lipid transporters, and transcriptional networks regulating their expression has provided the tools and insights needed to discern the molecular and cellular processes regulating the production and function of pulmonary surfactant prior to and after birth. Mutations in genes regulating surfactant homeostasis have been associated with severe lung disease in neonates ...
Source: Annual Review of Pathology - January 24, 2015 Category: Pathology Authors: Whitsett JA, Wert SE, Weaver TE Tags: Annu Rev Pathol Source Type: research

Malignant Solitary Fibrous Tumour of the Pleura: An Uncommon Entity.
PMID: 25631948 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Cruz Castellanos P, de Castro Carpeño J Tags: Arch Bronconeumol Source Type: research

Delayed Pulmonary Fibrosis (Usual Interstitial Pneumonia) in a Patient With Previous Uncomplicated H1N1-Associated Pneumonia.
PMID: 25631947 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Baietto G, Davoli F, Turello D, Rena O, Roncon A, Papalia E, Massera F, Casadio C Tags: Arch Bronconeumol Source Type: research

Extensive Endobronchial Lesions in a Patient With Stage 0 Sarcoidosis.
PMID: 25631946 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Lovis A, Noirez L, Letovanec I, Walker A Tags: Arch Bronconeumol Source Type: research

Bilateral Empyema Due to Spontaneous Esophageal Perforation.
PMID: 25631945 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Umezawa Makikado LD, Noriega Rocca CA, Gianella Malca GE Tags: Arch Bronconeumol Source Type: research

Paraneoplastic Cutaneous Vasculitis Associated With Lung Cancer.
PMID: 25631944 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Pantoja Zarza L, Díez Morrondo C, Castro Rodríguez E Tags: Arch Bronconeumol Source Type: research

Transmural Thoracic Lipoma.
PMID: 25631943 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 24, 2015 Category: Respiratory Medicine Authors: Sierra Solís A Tags: Arch Bronconeumol Source Type: research