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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Sweet Spot: Glucose Control in the Intensive Care Unit.
Abstract Hyperglycemia, hypoglycemia, and glycemic variability are all independently associated with morbidity and mortality of critically ill patients. A strategy aiming at normoglycemia (so-called tight glycemic control) could improve outcomes of critically ill patients, but results from randomized controlled trials of tight glycemic control are conflicting. Strict glycemic control is associated with an increased risk of hypoglycemia, which could offset the benefit of this intervention. Notably, the risk of hypoglycemia is not necessarily removed with less tight glucose control regimens. The best targets of blood...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: van Hooijdonk RT, Mesotten D, Krinsley JS, Schultz MJ Tags: Semin Respir Crit Care Med Source Type: research

What Is the Evidence for Harm of Neuromuscular Blockade and Corticosteroid Use in the Intensive Care Unit?
Abstract Neuromuscular blocking agents and corticosteroids are widely used in medicine and in particular in the intensive care unit (ICU). Neuromuscular blockade is commonly used to ease tracheal intubation, to optimize mechanical ventilation and oxygenation in acute respiratory disorders such as status asthmaticus and acute respiratory distress syndrome (ARDS), to prevent shivering during therapeutic hypothermia, and also in patients with elevated intracranial pressure. In the ICU, patients with sepsis, ARDS, community-acquired pneumonia, exacerbation of chronic obstructive pulmonary disease, severe asthma, or tra...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Annane D Tags: Semin Respir Crit Care Med Source Type: research

Balance between Hyperinflammation and Immunosuppression in Sepsis.
Abstract Sepsis is a major cause of morbidity and mortality among hospitalized patients and the leading cause of death among patients admitted to intensive care units. The immune response in sepsis is characterized by the activation of both proinflammatory and anti-inflammatory pathways. These pathways are concurrent, starting early in the course of sepsis. Given the high burden of morbidity and mortality associated with sepsis, there is an increasing interest in immunomodulatory therapies targeted at improving outcomes in sepsis. This review will summarize current understanding about the balance between hyperinfla...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Yadav H, Cartin-Ceba R Tags: Semin Respir Crit Care Med Source Type: research

How Cool It Is: Targeted Temperature Management for Brain Protection Post-Cardiac Arrest.
This article reviews the neuroprotective mechanisms of hypothermia, the evidence supporting targeted temperature management after cardiac resuscitation, areas of persistent uncertainty and controversy, and future research directions. PMID: 26820272 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Rabinstein AA Tags: Semin Respir Crit Care Med Source Type: research

Less Is More in the ICU: Resuscitation, Oxygenation and Routine Tests.
Abstract The intensive care unit (ICU) was initially developed in the 1950s to treat patients who required invasive respiratory support and hemodynamic resuscitation. Since the beginning, ICU medicine has focused on maintaining sufficient arterial blood flow and oxygenation to provide adequate tissue oxygen delivery to forestall or reverse organ failure. Over time, ICU medicine became more intensive, with the administration of many diagnostic tests and monitors, invasive procedures, and treatments, often with scant evidence of benefit associated with them. An alternative perspective holds that ICU patients may repr...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Gopalratnam K, Forde IC, O'Connor JV, Kaufman DA Tags: Semin Respir Crit Care Med Source Type: research

Too Much Oxygen: Hyperoxia and Oxygen Management in Mechanically Ventilated Patients.
Abstract Hyperoxia, or excess oxygen supplementation, prevails in the intensive care unit (ICU) without a beneficial effect and, in some instances, may cause harm. Recent interest and surge in clinical studies in mechanically ventilated critically ill patients has brought this to the attention of clinicians and researchers. Hyperoxia can cause alveolar injury, pulmonary edema, and subsequent systemic inflammatory response and is known to augment ventilator-associated lung injury. Liberal oxygenation practices are also associated with increased mortality in subsets of critically ill patients with post-cardiac arrest...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Pannu SR Tags: Semin Respir Crit Care Med Source Type: research

Too Little Oxygen: Ventilation, Prone Positioning, and Extracorporeal Membrane Oxygenation for Severe Hypoxemia.
Abstract Severe hypoxemia is associated with untoward outcomes in acute respiratory distress syndrome patients. Nevertheless, in and of itself, correction of hypoxemia is not an adequate surrogate outcome for mortality and clear evidence-based targets for correction of hypoxemia remain to be determined. At present, clinical management is directed toward achieving sufficient oxygenation while minimizing toxicity of ventilator-induced lung injury. The gold standard remains lung-protective mechanical ventilation, using lower-tidal volumes and pressure-limited ventilator titration. Notable progress in care includes fur...
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Park PK Tags: Semin Respir Crit Care Med Source Type: research

Controversies and Evolving Concepts in Critical Care.
PMID: 26820268 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - February 1, 2016 Category: Respiratory Medicine Authors: Cartin-Ceba R, Pannu S, Gajic O Tags: Semin Respir Crit Care Med Source Type: research

Blast from the past! Phrenic motor memory of antecedent episodic hypercapnia is serotonin dependent: relevance to respiratory rehabilitation and sleep‐disordered breathing?
(Source: Experimental Physiology)
Source: Experimental Physiology - February 1, 2016 Category: Physiology Authors: Ken D. O'Halloran Tags: Viewpoint Source Type: research

Evaluation of twenty‐two rapid antigen detection tests in the diagnosis of Equine Influenza caused by viruses of H3N8 subtype
ConclusionsThe study demonstrated the importance of choosing the right RAD tests as only three of 22 were fit for diagnosing EI. It was also indicated that even RAD tests with the highest sensitivity serve only as an adjunct to molecular tests because of the potential for false‐negative results. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - February 1, 2016 Category: Virology Authors: Takashi Yamanaka, Manabu Nemoto, Hiroshi Bannai, Koji Tsujimura, Takashi Kondo, Tomio Matsumura, Sarah Gildea, Ann Cullinane Tags: Original Article Source Type: research

Impact of neuraminidase inhibitors on influenza A(H1N1)pdm09‐related pneumonia: an individual participant data meta‐analysis
ConclusionsEarly NAI treatment of patients hospitalised with A(H1N1)pdm09 virus infection versus no treatment did not reduce the likelihood of IRP. However, in patients who developed IRP, early NAI treatment versus later reduced the likelihood of mortality and needing ventilatory support. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - February 1, 2016 Category: Virology Authors: Stella G. Muthuri, Sudhir Venkatesan, Puja R. Myles, Jo Leonardi‐Bee, Wei Shen Lim, Abdullah Al Mamun, Ashish P. Anovadiya, Wildo N. Araújo, Eduardo Azziz‐Baumgartner, Clarisa Báez, Carlos Bantar, Mazen M. Barhoush, Matteo Bassetti, Bojana Beovic, R Tags: Original Article Source Type: research

A further wheat allergen for baker’s asthma: Tri a 40
Baker's asthma and baker's rhinitis are still among the most frequent occupational respiratory disorders.1 Sensitization to inhaled wheat flour comprising an increasing number of identified allergen components plays a key role in the development and diagnosis of baker's disease.2 Recently, 19 recombinant wheat flour allergen components were evaluated in a group of 101 bakers from Germany, Spain, and The Netherlands in comparison with grass pollen–sensitized control subjects.3 However, allergen-specific IgE tests with whole wheat and rye flour extracts showed superior diagnostic sensitivity in comparison with component-re...
Source: Journal of Allergy and Clinical Immunology - February 1, 2016 Category: Allergy & Immunology Authors: Ingrid Sander, Hans-Peter Rihs, Thomas Brüning, Monika Raulf Tags: Correspondence Source Type: research

Characterization and anti-microbial susceptibility of bacterial isolates: Experience from a tertiary care cancer center in Delhi
Conclusion: We observed a high incidence of Gram-negative isolates with clinically significant resistance to first-line antibiotics such as cephalosporin's, piperacillin tazobactum, and fluoroquinolones. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - February 1, 2016 Category: Cancer & Oncology Authors: R SinghS JainR ChabbraR NaithaniA UpadhyayM Walia Source Type: research

The spectrum of respiratory pathogen among returning Hajj pilgrims: myth and reality.
(Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - February 1, 2016 Category: Infectious Diseases Authors: Phillipe Gautret, Samir Benkouiten, Jaffar A. Al-Tawfiq, Ziad A Memish Source Type: research

New Strategies to Prevent Ventilator-Associated Pneumonia: What to Do for Your Patients
Abstract The current rates of ventilator-associated pneumonia (VAP) are falling, in large part, as a result of effective prevention strategies. However, the application and efficacy of VAP prevention is being challenged by efforts to replace VAP surveillance with monitoring for ventilator-associated complications (VAC), which include many non-infectious processes. VAP prevention is based on interrupting pneumonia pathogenesis by avoiding the inoculation of contaminated oral secretions into the lower respiratory tract. This starts by using non-invasive ventilation in place of endotracheal intubation whenever possib...
Source: Current Treatment Options in Infectious Diseases - February 1, 2016 Category: Infectious Diseases Source Type: research

Perioperative Adverse Respiratory Events in Overweight/Obese Children: Systematic Review
Childhood obesity is associated with numerous respiratory disorders, which may be aggravated when general anesthesia is administered. This systematic review aimed to investigate and synthesize the published literature on the associations between childhood obesity and perioperative adverse respiratory events (PAREs). By using key terms, observational studies published between 1990 and 2014 in English-language journals indexed by Cumulative Index for Nursing and Allied Health Literature, PubMed, Web of Science, Cochrane Database, and EMBASE were searched for reports of relevant associations. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - February 1, 2016 Category: Nursing Authors: Panagiotis Kiekkas, Nikolaos Stefanopoulos, Nick Bakalis, Antonios Kefaliakos, Evangelos Konstantinou Tags: Original Article Source Type: research

Sinonasal Adenocarcinoma: Update on Classification, Immunophenotype and Molecular Features
Abstract Adenocarcinomas of the sinonasal tract may originate from respiratory surface epithelium or the underlying seromucinous glands. These malignancies are divided into salivary-type adenocarcinomas and non-salivary-type adenocarcinomas. The latter are further divided into intestinal-type and nonintestinal-type adenocarcinomas. This review provides an update on tumor classification, differential diagnostic considerations and molecular features, as well as new adenocarcinoma entities in the sinonasal area. (Source: Head and Neck Pathology)
Source: Head and Neck Pathology - February 1, 2016 Category: Pathology Source Type: research

Low-Grade Epithelial Proliferations of the Sinonasal Tract
Abstract Low-grade epithelial proliferations of the sinonasal tract include Schneiderian papillomas, respiratory epithelial adenomatoid hamartoma, seromucinous hamartoma and low-grade non-intestinal adenocarcinoma. There is considerable overlap in their clinical presentation, endoscopic appearance, and imaging features. Although well-described diagnostic criteria exist, a definitive diagnosis may be difficult to reach on a small biopsy. Schneiderian papillomas are divided into fungiform, inverted, and oncocytic types, each with characteristic clinical and morphological features. The latter two may progress to mali...
Source: Head and Neck Pathology - February 1, 2016 Category: Pathology Source Type: research

Aspiration and Non-Aspiration Pneumonia in Hospitalized Children With Neurologic Impairment
CONCLUSIONS: Hospitalized children with NI diagnosed with aspiration pneumonia have more complications and use more hospital resources than when diagnosed with nonaspiration pneumonia. Additional investigation is needed to understand the reasons for these differences. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2016 Category: Pediatrics Authors: Thomson, J., Hall, M., Ambroggio, L., Stone, B., Srivastava, R., Shah, S. S., Berry, J. G. Tags: Hospital Medicine, Infectious Disease Article Source Type: research

Hospital Utilization Among Children With the Highest Annual Inpatient Cost
CONCLUSIONS: Most children with high children’s hospital inpatient costs in 1 year do not experience hospitalization in subsequent years. Interactions of hospital use and clinical characteristics may be helpful to determine which children will continue to experience high inpatient costs over time. (Source: PEDIATRICS)
Source: PEDIATRICS - February 1, 2016 Category: Pediatrics Authors: Peltz, A., Hall, M., Rubin, D. M., Mandl, K. D., Neff, J., Brittan, M., Cohen, E., Hall, D. E., Kuo, D. Z., Agrawal, R., Berry, J. G. Tags: Administration/Practice Management, System-Based Practice, Advocacy, Child Health Financing Article Source Type: research

Retraction: Decline in NRF2-regulated Antioxidants in Chronic Obstructive Pulmonary Disease Lungs Due to Loss of Its Positive Regulator, DJ-1; Heightened Endoplasmic Reticulum Stress in the Lungs of Patients with Chronic Obstructive Pulmonary Disease: The Role of Nrf2-Regulated Proteasomal Activity.
Authors: PMID: 26829430 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Reply to "An Important Step Forward, but Still a Way to Go" and "Idiopathic Pulmonary Fibrosis and Prothrombotic State".
PMID: 26829429 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Rochwerg B, Schunemann H, Raghu G Tags: Am J Respir Crit Care Med Source Type: research

Reply to "An Important Step Forward, but Still a Way to Go".
PMID: 26829428 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Wilson KC Tags: Am J Respir Crit Care Med Source Type: research

Idiopathic Pulmonary Fibrosis and Prothrombotic State.
PMID: 26829427 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Fahim A, Crooks MG, Morice AH, Hart SP Tags: Am J Respir Crit Care Med Source Type: research

An Important Step Forward, but Still a Way to Go.
PMID: 26829426 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Wuyts WA, Bonella F, Costabel U, Cottin V, Kreuter M, Poletti V, Spagnolo P Tags: Am J Respir Crit Care Med Source Type: research

Delamanid and Bedaquiline Resistance in Mycobacterium tuberculosis Ancestral Beijing Genotype Causing Extensively Drug-Resistant Tuberculosis in a Tibetan Refugee.
PMID: 26829425 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Hoffmann H, Kohl TA, Hofmann-Thiel S, Merker M, Beckert P, Jaton K, Nedialkova L, Sahalchyk E, Rothe T, Keller PM, Niemann S Tags: Am J Respir Crit Care Med Source Type: research

Liver Dysfunction Is Associated with Long-Term Mortality in Septic Shock.
PMID: 26829424 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Nesseler N, Launey Y, Aninat C, White J, Corlu A, Pieper K, Mallédant Y, Seguin P Tags: Am J Respir Crit Care Med Source Type: research

"We Understand the Prognosis, but We Live with Our Heads in the Clouds": Understanding Patient and Family Outcome Expectations and Their Influence on Shared Decision Making.
PMID: 26829423 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Feemster LC, Curtis JR Tags: Am J Respir Crit Care Med Source Type: research

Is Continuous Positive Airway Pressure an Effective and Practical Antihypertensive Agent?
PMID: 26829422 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: White DP Tags: Am J Respir Crit Care Med Source Type: research

Dyspnea Intensity: A Patient-reported Measure of Respiratory Drive and Disease Severity.
PMID: 26829421 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Jolley CJ, Moxham J Tags: Am J Respir Crit Care Med Source Type: research

Gene Therapy with Adeno-associated Virus for Cystic Fibrosis.
PMID: 26829420 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 1, 2016 Category: Respiratory Medicine Authors: Karda R, Buckley SM, Waddington SN Tags: Am J Respir Crit Care Med Source Type: research