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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Specific and Non‐specific Clinical Presentations in the Year Before the Diagnosis of Childhood Leukaemia
ConclusionsWe described a clinical picture in the year before leukaemia diagnosis. These findings revealed ongoing difficulties in early diagnosis of childhood leukaemia in healthcare settings. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - April 29, 2016 Category: Cancer & Oncology Authors: TienYu Owen Yang, Yen‐Lin Liu, Wan‐Ting Huang, Mei‐Huei Chen, Pau‐Chung Chen Tags: Research Article Source Type: research

Is the lack of respiratory gating prejudicial for left breast TomoDirect treatments?
Breast cancer is the most common women cancer, with an incidence rate of over one million cases per year worldwide [1]. Radiation therapy has a major role in the management of this disease, to reduce local recurrence and improve overall survival probability [2]. This treatment modality has long been suspected of causing cardiac toxicities, especially for left breast cases. These toxicities were confirmed notably by a large follow-up work conducted by Darby et al. over 2158 patients [3], which showed that the risk of coronary events would increase by 7.4% per gray delivered to the heart, even if the possibility of a thresho...
Source: Physica Medica: European Journal of Medical Physics - April 29, 2016 Category: Journals (General) Authors: Philippe Meyer, Claudine Niederst, Maximilien Scius, Delphine Jarnet, Nicolas Dehaynin, Matthieu Gantier, Waisse Waissi, Nicolas Poulin, Diran Karamanoukian Tags: Original paper Source Type: research

Convex probe EBUS for centrally located parenchymal lesions without a bronchus sign
Convex probe endobronchial ultrasound (CP-EBUS) has proven safe and accurate for identifying malignancy and granulomatous disease affecting the mediastinum and hilum. For the diagnosis of parenchymal lung lesions, conventional techniques such as transbronchial biopsy, brush and lavage are useful, particularly when an airway leads directly to the lesion. For centrally located intraparenchymal lesions, CP-EBUS has been shown to be efficacious. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 29, 2016 Category: Respiratory Medicine Authors: A. Christine Argento, Jonathan Puchalski Source Type: research

Probability of IV antibiotic retreatment within thirty days is associated with duration and location of IV antibiotic treatment for pulmonary exacerbation in cystic fibrosis
There are few objective data to guide management of cystic fibrosis (CF) pulmonary exacerbations. We studied intravenous (IV) antibiotic treatment failure as defined by a need to retreat patients with IV antibiotics within 30days of completion of a prior IV antibiotic treatment for pulmonary exacerbation. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 29, 2016 Category: Respiratory Medicine Authors: D.R. VanDevanter, P.A. Flume, N. Morris, M.W. Konstan Tags: Original Article Source Type: research

Variation of glucose tolerance in adult patients with cystic fibrosis: What is the potential contribution of insulin sensitivity?
Reduced insulin secretion is a key factor to explain high prevalence of glucose intolerance in patients with cystic fibrosis (CF). However, the role of insulin sensitivity remains unclear. The aim of this study is to investigate the association of insulin secretion and sensitivity with the evolution of glucose tolerance. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 29, 2016 Category: Respiratory Medicine Authors: Valérie Boudreau, Adèle Coriati, Imane Hammana, Sophie Ziai, Katherine Desjardins, Yves Berthiaume, Rémi Rabasa-Lhoret Tags: Original Article Source Type: research

A systematic review comparing laparoscopic versus open adhesiolysis in patients with adhesional small bowel obstruction
Conclusion Laparoscopic adhesiolysis for ASBO seems to have clinically proven advantage over open approach Teaser Current systematic review of 14 comparative studies on 38057 patients indicates that the laparoscopic adhesiolysis for adhesional small bowel obstruction improves post-operative clinical outcomes with reduced post-operative morbidity and mortality. Laparoscopic adhesiolysis may safely be performed in patients with adhesional bowel obstruction in whom the procedure is deemed feasible. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - April 29, 2016 Category: Surgery Source Type: research

Clinical spectrum of the Middle East respiratory syndrome coronavirus (MERS-CoV)
Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized as a cause of severe acute respiratory infection in the Kingdom of Saudi Arabia in 2012. As of February 2, 2016, 1638 laboratory-confirmed cases have been reported to the World Health Organization, including at least 587 deaths [1]. While MERS-CoV has affected 26 countries, the majority of cases have been reported in the Middle East [2]. Transmission has most commonly been associated with nosocomial outbreaks [3–7] and is occasionally due to animal-to-human (most commonly camel-to-human) transmission and sporadic human-to-human transmission in t...
Source: Journal of Infection and Public Health - April 29, 2016 Category: Global & Universal Authors: Mikiko Senga, Yaseen M. Arabi, Robert A. Fowler Source Type: research

A Comparative Study of Lung Host Defense in Murine Obesity Models: Insights Into Neutrophil Function.
CONCLUSIONS: Obesity-associated impairment of host response to lung infection is characterized by defects in neutrophil recruitment and survival. Yet, critical differences exist between commonly used mouse models of obesity, and may reflect variable penetrance of elements of the metabolic syndrome as well as other factors. PMID: 27128821 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 29, 2016 Category: Molecular Biology Authors: Ubags ND, Burg E, Antkowiak M, Wallace AM, Dilli E, Bement J, Wargo MJ, Poynter ME, Wouters EF, Suratt BT Tags: Am J Respir Cell Mol Biol Source Type: research

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the in vitro and in vivo Models of ARDS
Abstract Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The mechanism of this effect is not fully elucidated yet. The primary objective of this study was to investigate the hypothesis that the antimicrobial effect of MSC in vivo depends on their modulation of macrophage phagocytic activity which occurs through mitochondrial transfer. We established that selective depletion of alveolar macrophages (AM) with intranasal (IN) administration of liposomal clodronate resulted in complete abrogation of MSC antimicrobi...
Source: Stem Cells - April 29, 2016 Category: Stem Cells Authors: Megan V Jackson, Thomas J Morrison, Declan F Doherty, Daniel F McAuley, Michael A Matthay, Adrien Kissenpfennig, Cecilia M O'Kane, Anna D Krasnodembskaya Tags: Translational and Clinical Research Source Type: research

The enlightenments from ITMIG Consensus on WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Authors: Wu J, Fang W, Chen G Abstract The World Health Organization (WHO) histological classification of the thymoma and thymic carcinoma (TC) has been criticized for poor interobserver reproducibility or inconsistencies in the routine pathological diagnosis. The International Thymic Malignancy Interest Group (ITMIG) panel achieved an agreement to maintain the widely accepted WHO framework but to refine historic definitions and histological criteria, and further introduce some new terms with the aim to improve interobserver reproducibility. This review addresses the enlightenments we can get from the ITMIG consens...
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database.
CONCLUSIONS: Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination. Further study using prospectively recorded information on the proposed TNM categories would be helpful to better grouping thymic tumors for predicting prognosis and guiding clinical management. PMID: 27114841 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Clinicopathological analysis of 241 thymic epithelial tumors-experience in the Shanghai Chest Hospital from 1997-2004.
CONCLUSIONS: WHO histological subtype, Masaoka stage and (neo-)adjuvant treatment have remained independent determinants of OS in patients with thymomas and TCs. Compared with the historical cohort during 1969-1996, prognosis of patients with B2, B3 thymomas has improved, which may be partly due to the increased use of adjuvant therapies. Prognosis of patients with TCs remained unsatisfactory, suggesting that neoadjuvant treatment should be tested to improve survival. PMID: 27114840 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Postoperative survival for patients with thymoma complicating myasthenia gravis-preliminary retrospective results of the ChART database.
CONCLUSIONS: Although MG is not an independent prognostic factor, the survival of patients with thymoma was superior when MG was present, especially in late Masaoka stage patients. Possible reasons included early diagnosis of the tumor, better histologic types, an overall higher R0 resection and less recurrence. PMID: 27114839 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Outcome of nonsurgical treatment for locally advanced thymic tumors.
CONCLUSIONS: When used to treat locally advanced thymic tumors unsuitable for surgery, CCRT performed more favorably than RT alone or SCRT in both tumor response and long time survival, but probably with the increasing risk of pulmonary damage. CCRT may offer the best chance of disease control in the management of locally advanced disease. PMID: 27114838 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The application of postoperative chemotherapy in thymic tumors and its prognostic effect.
CONCLUSIONS: Pathologically higher grade histology, incomplete resection, and postoperative radiotherapy were found to be associated with worse outcomes in advanced stage thymic tumors. At present, there is no evidence to show that postoperative chemotherapy may help improve prognosis in patients with Masaoka-Koga stage III and IV thymic tumors. PMID: 27114837 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of postoperative radiotherapy for stage I/II/III thymic tumor-results of the ChART retrospective database.
CONCLUSIONS: The current retrospective study indicates that PORT after incomplete resection could improve OS and DFS for patients with stage I to III thymic tumors. However for those after complete resection, PORT does not seem to have any survival benefit on the whole. PMID: 27114836 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis.
CONCLUSIONS: Thymectomy, instead of tumor resection alone, should still be recommended as the surgical standard for thymic malignancies, especially for stage II tumors and those with concomitant MG. PMID: 27114835 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Perioperative outcomes and long-term survival in clinically early-stage thymic malignancies: video-assisted thoracoscopic thymectomy versus open approaches.
CONCLUSIONS: This study suggests that VATS thymectomy is an effective approach for clinically early-stage thymic malignancies. And it may offer better perioperative outcomes, as well as equal oncological survival. PMID: 27114834 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Preoperative induction therapy for locally advanced thymic tumors: a retrospective analysis using the ChART database.
CONCLUSIONS: Preoperative neoadjuvant therapy have been used only occasionally in locally advanced thymic malignances. Effective induction therapy leading to tumor downstaging may be beneficial for potentially unresectable diseases, especially in patients with thymomas. These findings would be helpful to related studies in the future. PMID: 27114833 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pretreatment biopsy for histological diagnosis and induction therapy in thymic tumors.
CONCLUSIONS: It is crucial to get histological diagnosis for thymoma before surgery or adjuvant treatment and minimally invasive biopsy should be undertaken. Although in our study we could not find the benefit of induction chemotherapy before surgery in survival and recurrence rate, it could increase the R0 resection rate compared with direct surgery in late stage (III and IVa). PMID: 27114832 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

CT staging and preoperative assessment of resectability for thymic epithelial tumors.
CONCLUSIONS: Clinical staging of TET could be accurately evaluated with CT features including tumor shape, contour, enhancement pattern, with or without invasion of adjacent structures, and presence of pleural, pericardial effusion or intrapulmonary metastasis. Absence of arterial system invasion on CT was the only predictive feature for predicting complete resection of TET. PMID: 27114831 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Management of thymic tumors-consensus based on the Chinese Alliance for Research in Thymomas Multi-institutional retrospective studies.
Authors: Fang W, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen K, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Chen G, Members of the Chinese Alliance for Research in Thymomas PMID: 27114830 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Journal of Thoracic Disease Focused Issue: Management of Thymoma.
Authors: Korst RJ PMID: 27114829 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Treatment and monitoring of hypersensitivity pneumonitis.
Authors: Miyazaki Y, Tsutsui T, Inase N Abstract Hypersensitivity pneumonitis (HP) is an immunologically induced lung disease that develops after inhalation of certain environmental antigens only in subjects with susceptibility to antigens. Therefore, both environmental and host immunological factors play important roles in the aetiology and pathogenesis of HP. Determination of an inciting antigen is crucial for diagnosis, treatment and monitoring. For treatment, modification of the environment and of the host immune response are important. The former includes reduction of antigenic burden (i.e. disinfectant, clean...
Source: Expert Review of Clinical Immunology - April 28, 2016 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Poor agreement between diagnostic tests for latent tuberculosis infection among HIV‐infected persons in Hong Kong
ConclusionMajor discordance in positive results, high reversion rates and low tuberculosis incidence among test‐positive subjects cast serious doubt on the utility of the currently available LTBI tests in the annual screening of HIV‐infected persons in an intermediate tuberculosis burden area. (Source: Respirology)
Source: Respirology - April 28, 2016 Category: Respiratory Medicine Authors: Chi Chiu Leung, Kenny Chan, Wing Cheong Yam, Man Po Lee, Chi Kuen Chan, Ka Hing Wong, Pak Leung Ho, Ida Mak, Cheuk Ming Tam Tags: Original Article Source Type: research

Changes in heart rate variability during vasomotor symptoms among midlife women
This study tested whether acute decreases in cardiac vagal control would occur with VMS in a large sample of women monitored during wake and sleep. Methods: Two hundred and fifteen nonsmoking women aged 40 to 60 years with evidence of VMS were included. Women were free of a history of clinical cardiovascular disease or arrhythmia; or use of insulin, beta blockers, calcium channel blockers, or medications impacting VMS. Women underwent 24 hours of ambulatory monitoring for physiological (sternal skin conductance) and self-report (electronic diary) measurement of VMS; heart rate variability (electrocardiogram); and respir...
Source: Menopause - April 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

A Novel Drug Delivery System for the Human Nasal Epithelium.
Authors: Takano K, Kojima T, Keira T, Miyata R, Nomura K, Kakuki T, Kaneko Y, Yajima R, Kakiuchi A, Himi T Abstract The epithelium of upper respiratory tissues such as the human nasal mucosa forms a continuous barrier via tight junctions (TJs). The development of a drug delivery system for use across the nasal mucosa is being reconsidered. In intranasal administration across the nasal mucosa, the paracellular pathway regulated by TJs is extremely important. It is known that the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds the TJ protein claudin and disrupts the tight junctional barrier w...
Source: Advances in Oto-Rhino-Laryngology - April 28, 2016 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research

Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure
High flow nasal cannula (HFNC) supportive therapy has emerged as a safe, useful therapy in patients with respiratory failure, improving oxygenation and comfort. Recently several clinical trials have analyzed t... (Source: Critical Care)
Source: Critical Care - April 28, 2016 Category: Intensive Care Authors: Oriol Roca, Gonzalo Hernández, Salvador Díaz-Lobato, José M. Carratalá, Rosa M. Gutiérrez and Joan R. Masclans Source Type: research

Unusual presentation: Concurrent IgA deficiency and idiopathic pulmonary hemosiderosis
Summary Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder that should be considered in the differential diagnosis of patients with hemoptysis, recurrent alveolar hemorrhage, dyspnea and iron deficiency anemia (IDA). The frequent association of autoimmune disorders with IPH and a favorable response to steroids suggest the presence of an underlying immune disorder. Here we present a case of a patient with cough, fever, and cyanosis who was also diagnosed with IPH and concurrent selective immunoglobulin A deficiency. This presentation is a unique presentation because of the co‐occurrence of these two disorders. Pe...
Source: Pediatric Pulmonology - April 28, 2016 Category: Respiratory Medicine Authors: Mustafa Erkoçoğlu, Ersoy Civelek, Can Naci Kocabaş Tags: Case Report Source Type: research

Airway reconstruction: review of an approach to the advanced-stage laryngotracheal stenosis
Conclusion The review of our approach to open airway repair/reconstruction showed its efficacy in advanced-stage laryngotracheal stenosis. Good knowledge of a variety of reconstructive techniques is important to achieve good results in a variety of age groups. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - April 28, 2016 Category: ENT & OMF Source Type: research

Early mortality in multiple myeloma: the time‐dependent impact of comorbidity: A population‐based study in 621 real‐life patients
Multiple myeloma is a heterogeneous disease with variable survival; this variability cannot be fully explained by the current systems of risk stratification. Early mortality remains a serious obstacle to further improve the trend toward increased survival demonstrated in recent years. However, the definition of early mortality is not standardized yet. Importantly, no study has focused on the impact of comorbidity on early mortality in multiple myeloma to date. Therefore, we analyzed the role of baseline comorbidity in a large population‐based cohort of 621 real‐life myeloma patients over a 31‐year period. To evaluate...
Source: American Journal of Hematology - April 28, 2016 Category: Hematology Authors: Rafael Ríos‐Tamayo, Juan Sáinz, Joaquín Martínez‐López, José Manuel Puerta, Daysi‐Yoe‐Ling Chang, Teresa Rodríguez, Pilar Garrido, José Luís García de Veas, Antonio Romero, Lucía Moratalla, Elisa López‐Fernández, Pedro Antonio Gonz Tags: Research Article Source Type: research

Bilateral intermediate uveitis with appearance of frosted branch angiitis and associated with Mycoplasma pneumoniae infection: case report and review of the literature
A 12-year-old girl presented with acute bilateral visual loss following a mild upper respiratory tract infection. Clinical examination revealed bilateral severe peripheral retinal vasculitis with an appearance of frosted branch angiitis and cystoid macular edema. All tests for etiological diagnosis were negative, apart from positive IgM and IgG antibodies for Mycoplasma pneumoniae. She was treated with broad-spectrum antibiotics and intravenous corticosteroids. She responded to treatment, with dramatic improvement of her visual acuity, remission of angiitis, and a residual macular star formation. (Source: Journal of AAPOS)
Source: Journal of AAPOS - April 28, 2016 Category: Opthalmology Authors: Artemis Matsou, Paraskevi Riga, Maria Samouilidou, Stavros Dimitrakos, Eleftherios Anastasopoulos Tags: Short Report Source Type: research

Six minute walk test versus incremental shuttle walk test in cystic fibrosis
ConclusionsThe ISWT is a better reflection of exercise tolerance in CF than 6MWT. ISWT is a preferable alternative assessment of exercise tolerance in terms of cardiorespiratory response. (Source: Pediatrics International)
Source: Pediatrics International - April 28, 2016 Category: Pediatrics Authors: Melda Saglam, Naciye Vardar‐Yagli, Sema Savci, Deniz Inal‐Ince, Zeynep Aribas, Meral Bosnak‐Guclu, Hulya Arikan, Ebru Calik‐Kutukcu, Ebru Gunes‐Yalcin Tags: Original Article Source Type: research

Moving the mean with feedback: insights from behavioural science
npj Primary Care Respiratory Medicine, Published online: 28 April 2016; doi:10.1038/npjpcrm.2016.18 (Source: npj Primary Care Respiratory Medicine)
Source: npj Primary Care Respiratory Medicine - April 28, 2016 Category: Primary Care Authors: Jeffrey A Linder Source Type: research

Health literacy and health outcomes in chronic obstructive pulmonary disease
There is little information worldwide about the impact of health literacy (HL) on clinical outcomes of COPD. Our aim was to quantify inadequate HL in Spain, as measured by the Short Assessment of Health Literacy for Spanish Adults questionnaire, and to examine the associations between HL and both COPD outcomes and health status. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 28, 2016 Category: Respiratory Medicine Authors: Luis Puente-Maestu, Myriam Calle, Juan Luis Rodríguez-Hermosa, Anna Campuzano, Javier de Miguel Díez, Jose Luis Álvarez-Sala, Luis Puente-Andues, Maria Joselín Pérez Gutiérrez, Shoou-Yih D. Lee Source Type: research

Lung clearance index for monitoring early lung disease in alpha-1-antitrypsin deficiency
Patients with alpha-1-antitrypsin deficiency (AATD) and a PI-ZZ genotype are at high risk to develop severe emphysema during adulthood. However, little is known about early stages of emphysema and disease manifestation in other PI-types. Spirometry is commonly used for monitoring although early manifestation of emphysema is suspected within the peripheral airways that are not accessible by forced expiratory manoeuvres.We hypothesized that the Lung Clearance Index (LCI) derived from multiple breath nitrogen-washout (N2-washout) is useful to bridge this diagnostic gap. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 28, 2016 Category: Respiratory Medicine Authors: Susanne I. Fuchs, Nicolaus Schwerk, Klaus Pittschieler, Frank Ahrens, Winfried Baden, Robert Bals, Sebastian Fähndrich, Wolfgang Gleiber, Matthias Griese, Georg Hülskamp, Thomas Köhnlein, Ludmilla Reckling, Ernst Rietschel, Doris Staab, Monika Gappa Source Type: research

Optimizing beta-lactam pharmacodynamics against Pseudomonas aeruginosa in adult cystic fibrosis patients
Patients with cystic fibrosis (CF) exhibit increased clearance of beta-lactams. The purpose of this study was to predict the probability of beta-lactam target attainment (PTA) against Pseudomonas aeruginosa in adult CF patients based on local microbiological data. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 28, 2016 Category: Respiratory Medicine Authors: R. Zachary Thompson, Craig A. Martin, Donna R. Burgess, W. Cliff Rutter, David S. Burgess Tags: Short Communication Source Type: research

Sports injuries and illnesses during the 2015 Winter European Youth Olympic Festival
Conclusions Four per cent of the athletes suffered from an injury and 4% from illnesses during the 2015 W-EYOF, which is about twofold lower compared to the first Winter Youth Olympic Games in 2012. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - April 28, 2016 Category: Sports Medicine Authors: Ruedl, G., Schnitzer, M., Kirschner, W., Spiegel, R., Platzgummer, H., Kopp, M., Burtscher, M., Pocecco, E. Tags: Ice hockey, Trauma, Injury Original article Source Type: research

Association Between Markers of Classroom Environmental Conditions and Teachers' Respiratory Health
CONCLUSIONSAsthma, respiratory infections, colds, eye irritation, nasal congestion, and sore throat were associated with the classroom environment. Results indicate that the school environment could affect teachers' respiratory health. Further assessments are necessary to establish causation. (Source: Journal of School Health)
Source: Journal of School Health - April 28, 2016 Category: Health Management Authors: Luz Claudio, Glory A. Rivera, Olivia F. Ramirez Tags: RESEARCH ARTICLE Source Type: research

Modelling collinear and spatially correlated data
Publication date: Available online 27 April 2016 Source:Spatial and Spatio-temporal Epidemiology Author(s): Silvia Liverani, Aurore Lavigne, Marta Blangiardo In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in the presence of i) high correlation between the predictors and ii) spatial correlation for the response. Covariates which are highly correlated create collinearity problems when used in a standard multiple regression model. Many methods have been proposed in the literature to address th...
Source: Spatial and Spatio-temporal Epidemiology - April 28, 2016 Category: Epidemiology Source Type: research

A proportional assist ventilator to unload respiratory muscles experimentally during exercise in humans
We describe the creation of a PAV that permits researchers to use it as an experimental tool. Manipulation of the normally occurring work of breathing (WOB) during exercise can provide insights into whole‐body regulatory mechanisms in clinical patients and healthy subjects. One method to reduce the WOB uses a proportional assist ventilator (PAV). Suitable commercially available units are not capable of being used during heavy exercise. This investigation was undertaken in order to create a PAV and assess the degree to which the WOB could be reduced during exercise. A PAV works by creating a positive mouth pressure (Pm)...
Source: Experimental Physiology - April 28, 2016 Category: Physiology Authors: Paolo B. Dominelli, William R. Henderson, A. William Sheel Tags: Research Paper Source Type: research

Innate-like function of memory Th17 cells for enhancing endotoxin-induced acute lung inflammation through IL-22
Lipopolysaccharide (LPS)-induced acute lung injury (ALI) is known as a mouse model of acute respiratory distress syndrome; however, the function of T-cell-derived cytokines in ALI has not yet been established. We found that LPS challenge in one lung resulted in a rapid induction of innate-type pro-inflammatory cytokines such as IL-6 and TNF-α, followed by the expression of T-cell-type cytokines, including IL-17, IL-22 and IFN-. We discovered that IL-23 is important for ALI, since blockage of IL-23 by gene disruption or anti-IL-12/23p40 antibody treatment reduced neutrophil infiltration and inflammatory cytokine secre...
Source: International Immunology - April 28, 2016 Category: Allergy & Immunology Authors: Sakaguchi, R., Chikuma, S., Shichita, T., Morita, R., Sekiya, T., Ouyang, W., Ueda, T., Seki, H., Morisaki, H., Yoshimura, A. Tags: Original Research Source Type: research

Effects of dexmedetomidine on hemodynamics and respiration in intubated, spontaneously breathing patients after endoscopic submucosal dissection for cervical esophageal or pharyngeal cancer
Conclusion Dexmedetomidine in intubated, spontaneously breathing patients after ESD was safe and effective. Patient baseline hemodynamics could significantly affect hemodynamics during drug infusion. Without loading doses, plasma drug concentrations were expected to increase progressively. A progressive decrease in blood pressure and unchanged heart rate after an initial decrease suggested that hemodynamic effects of dexmedetomidine in our patients might differ from those reported in young volunteers, although further studies are required to elucidate these points. (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - April 28, 2016 Category: Anesthesiology Source Type: research

Deep versus moderate neuromuscular block during one-lung ventilation in lung resection surgery
Conclusions Deep neuromuscular blockade attenuates the poor lung mechanics observed during one-lung ventilation. (Source: Brazilian Journal of Anesthesiology)
Source: Brazilian Journal of Anesthesiology - April 28, 2016 Category: Anesthesiology Source Type: research

Next generation sequencing analysis of lung cancer datasets: A functional genomics perspective
P Pappu, D Madduru, M Chandrasekharan, V Modhukur, S Nallapeta, P SuravajhalaIndian Journal of Cancer 2016 53(1):1-7Cigarette smoking leads to serious epidemics in humans, creating torsion of infection in epithelial cells lining the respiratory tracts. Several researchers in the recent past have theorized that the next generation sequencing (NGS), especially transcriptome sequencing has enhanced understanding lung cancers and other epithelial epidemics. Conversely, pathogenesis specific to lung cancer with respect to molecular fraction of genomic ribonucleic acid has some mutant effect in various populations like smokers w...
Source: Indian Journal of Cancer - April 28, 2016 Category: Cancer & Oncology Authors: P PappuD MadduruM ChandrasekharanV ModhukurS NallapetaP Suravajhala Source Type: research

Twice-weekly palliative radiotherapy for locally very advanced head and neck cancers
Conclusion: The proposed radiotherapy regimen is effective for sustained symptom palliation with low acute toxicity in locally very advanced head and neck cancers. It delivers a moderately high dose while being logistically simpler for the patient. (Source: Indian Journal of Cancer)
Source: Indian Journal of Cancer - April 28, 2016 Category: Cancer & Oncology Authors: V MurthyDP KumarA BudrukkarT GuptaS Ghosh-LaskarJ Agarwal Source Type: research

Clozapine and olanzapine are better antioxidants than haloperidol, quetiapine, risperidone and ziprasidone in in vitro models
This study demonstrated that both clozapine and olanzapine have antioxidant effects, in vitro, by scavenging superoxide anion on the respiratory burst, donating electron in the ABTS+ assay and stabilizing the radical DPPH. Ziprasidone significantly scavenged ABTS+ and stabilized the radical DPPH whereas risperidone significantly reduced the respiratory burst. Haloperidol and quetiapine lacked antioxidant effects. The chemical structure-related antioxidant capacity suggests a possible neuroprotective mechanism of these drugs on the top of their antipsychotic mechanism of action. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 28, 2016 Category: Drugs & Pharmacology Source Type: research