Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Smooth Muscle Insulin-like Growth Factor-1 Mediates Hypoxia-induced Pulmonary Hypertension in Neonatal Mice.
In this study, we hypothesized that hypoxia-induced upregulation of IGF-1 in vascular smooth muscle is directly responsible for pulmonary vascular remodeling and pulmonary hypertension. We studied neonatal and adult mice with smooth muscle-specific deletion of IGF-1 and also used an inhibitor of IGF-1 receptor (IGF-1R), OSI-906, in neonatal mice. We found that in neonatal mice, smooth muscle cell-specific deletion of IGF-1 or IGF-1R inhibition with OSI-906 attenuated hypoxia-induced pulmonary vascular remodeling in small arteries, right ventricular hypertrophy, and right ventricular systolic pressure. Pulmonary artery smoo...
Source: Am J Respir Cell Mol... - July 20, 2016 Category: Respiratory Medicine Authors: Sun M, Ramchandran R, Chen J, Yang Q, Raj JU Tags: Am J Respir Cell Mol Biol Source Type: research

Unique and Redundant Functions of P70S6K Isoforms Regulate Mesenchymal Cell Proliferation and Migration in Pulmonary Fibrosis.
Abstract The p70 ribosomal S6 kinase (p70S6K) is a downstream substrate that is phosphorylated and activated by the mTOR complex and regulates multiple cellular processes associated with pulmonary fibrogenesis. Two isoforms of the p70S6K have been identified (S6K1 and S6K2), but their relative contributions in mediating pulmonary fibrosis are unknown. To interrogate the roles of the p70S6K isoforms, we overexpressed TGFα in mice deficient for the S6K1 or S6K2 genes and measured changes in lung histology, morphometry, total lung collagen, lung function and proliferation between wild type and isoform deficient mice....
Source: Am J Respir Cell Mol... - July 20, 2016 Category: Respiratory Medicine Authors: Madala SK, Sontake V, Edukulla R, Davidson CR, Schmidt S, Hardie WD Tags: Am J Respir Cell Mol Biol Source Type: research

Clinicians' perspective on key domains in ANCA-associated vasculitis: a Delphi exercise.
CONCLUSIONS: Clinical experts focus on the physiological effects of AAV with less importance given to the effect of AAV on patients' activities and participation in life situations and the role of contextual factors. This study represents a step towards incorporating views of a range of stakeholders into disease assessment in AAV. PMID: 27438345 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - July 20, 2016 Category: Rheumatology Authors: Milman N, Boonen A, Tugwell P, Merkel PA, OMERACT Vasculitis Working Group Tags: Scand J Rheumatol Source Type: research

Evaluating the utility of Binax NOW Streptococcus pneumoniae urinary antigen test in adults with community acquired pneumonia in China.
CONCLUSION: ICT test has a moderate sensitivity and high specificity in adults with CAP in China. Patients classified as sever pneumonia, or those with BUN>7 mmol/L, or PCT>2 ng/ml are more likely to have positive results. This article is protected by copyright. All rights reserved. PMID: 27437639 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 20, 2016 Category: Respiratory Medicine Authors: Zhou F, Gu L, Qu J, Liu Y, Cao B, For CAP-China network Tags: Clin Respir J Source Type: research

Haze is a risk factor contributing to the rapid spread of respiratory syncytial virus in children.
This study investigated whether respiratory syncytial virus (RSV) infection in children was associated with ambient temperature and air pollutants in Hangzhou, China. A distributed lag non-linear model (DLNM) was used to estimate the effects of daily meteorological data and air pollutants on the incidence of RSV infection among children. A total of 3650 childhood RSV infection cases were included in the study. The highest air pollutant concentrations were in January to May and October to December during the year. The yearly RSV-positive rate was 10.0 % among children with an average age of 4.3 months. The highest RSV-pos...
Source: Environmental Science and Pollution Research International - July 20, 2016 Category: Environmental Health Authors: Ye Q, Fu JF, Mao JH, Shang SQ Tags: Environ Sci Pollut Res Int Source Type: research

Effects of selective carotid body stimulation with adenosine in conscious humans.
This article is protected by copyright. All rights reserved. PMID: 27435894 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - July 20, 2016 Category: Physiology Authors: Tubek S, Niewinski P, Reczuch K, Janczak D, Rucinski A, Paleczny B, Engelman ZJ, Banasiak W, Paton JF, Ponikowski P Tags: J Physiol Source Type: research

The effect of obstructive sleep apnea syndrome and hypothyroidism to intima-media thickness of carotid artery.
CONCLUSION: We suggest, physicians should be alert for hypothyroidism comorbidity in OSAS, and suspected subjects with OSAS should be screened for hypothyroidism considering the potential cardiovascular complications. PMID: 27438724 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 20, 2016 Category: Sleep Medicine Authors: Bozkus F, Dikmen N, Güngör G, Samur A Tags: Sleep Breath Source Type: research

Cardiac output: a central issue in patients with respiratory extracorporeal support.
Abstract The iLA-activve(®) Novalung is a new extracorporeal device specifically designed for lung support in patients with hypercapnic and/or hypoxemic respiratory failure. To date, only low-flow applications for decompensated hypercapnic chronic obstructive pulmonary disease have been reported in the literature. Here, we briefly report three cases of iLA-activve use in patients with hypercapnic-hypoxemic acute lung failure assisted with mid-flow (up to 2.4 L/min) and different single/double venous cannulation. The main findings of our small case series were: firstly, extracorporeal blood flows over 2.0 L/min acr...
Source: Perfusion - July 20, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Romagnoli S, Zagli G, Ricci Z, Villa G, Barbani F, Pinelli F, De Gaudio R, Chelazzi C Tags: Perfusion Source Type: research

Muscle Signaling in Exercise Intolerance: Insights from the McArdle Mouse Model
Conclusion: Myophosphorylase deficiency causes alterations in sensory energetic pathways together with some evidence of oxidative damage and alterations in Ca2+ handling but with no major alterations in oxidative phosphorylation capacity or autophagy/ubiquitination pathways, which suggests that the muscle tissue of patients is likely to adapt overall favorably to exercise training interventions. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - July 19, 2016 Category: Sports Medicine Tags: Basic Sciences Source Type: research

Does 6-Month Home Caregiver-Supervised Physiotherapy Improve Post-Critical Care Outcomes?: A Randomized Controlled Trial
Conclusions: Carrying over regular bronchial hygiene techniques, physical activity, and exercise into the home after long critical care stays is safe and has a beneficial effect on respiratory muscles, decannulation, pulmonary function, and quality of life. (Source: American Journal of Physical Medicine and Rehabilitation)
Source: American Journal of Physical Medicine and Rehabilitation - July 19, 2016 Category: Rehabilitation Tags: Original Research Articles Source Type: research

COPD patients who use opioids at risk from respiratory complications
Older patients with chronic obstructive pulmonary disease who take opioids to relieve their symptoms increase their risk of dying from a respiratory-related complication compared with non-opioid users, according to new research. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - July 19, 2016 Category: Drugs & Pharmacology Source Type: research

Obstructive Sleep Apnea: Using Stop Bang to Help Prevent Post-operative Complications
Patients with obstructive sleep apnea (OSA) are at higher risk for fatal post-operative complications including: death, stroke, myocardial infarction, and respiratory failure. Upon investigating postoperative respiratory failure within our enterprise, it was determined that we were not identifying patients who were at risk for OSA complications. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - July 19, 2016 Category: Nursing Authors: Kerrie Brewer, Megan Templeman, Amanda Carney, Amanda Pascal Source Type: research

Cellular Stress Responses and Monitored Cellular Activities
ABSTRACT: To survive, organisms require mechanisms that enable them to sense changes in the outside environment, introduce necessary responses, and resist unfavorable distortion. Consequently, through evolutionary adaptation, cells have become equipped with the apparatus required to monitor their fundamental intracellular processes and the mechanisms needed to try to offset malfunction without receiving any direct signals from the outside environment. It has been shown recently that eukaryotic cells are equipped with a special mechanism that monitors their fundamental cellular functions and that some pathogenic proteobacte...
Source: Shock - July 19, 2016 Category: Emergency Medicine Tags: Review Articles Source Type: research

SN50, a Cell-Permeable Inhibitor of Nuclear Factor-κB, Attenuates Ventilator-Induced Lung Injury in an Isolated and Perfused Rat Lung Model
In conclusion, VILI is associated with inflammatory responses and activation of NF-κB. SN50 inhibits the activation of NF-κB and attenuates VILI. (Source: Shock)
Source: Shock - July 19, 2016 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Hospital Variation in Early Tracheostomy in the United States: A Population-Based Study*
Conclusion: Early tracheostomy is potentially overused among mechanically ventilated trauma patients, with nearly half of tracheostomies performed within the first week of mechanical ventilation and large unexplained hospital variation, without clear benefits. Future studies are needed to characterize potentially differential benefits for early tracheostomy between disease subgroups and to investigate factors driving hospital variation in tracheostomy timing. (Source: Critical Care Medicine)
Source: Critical Care Medicine - July 19, 2016 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Low Tidal Volume Ventilation Use in Acute Respiratory Distress Syndrome*
Conclusions: More than 12 years after publication of the landmark low tidal volume ventilation study, use remains poor. Interventions that improve adoption of low tidal volume ventilation are needed. (Source: Critical Care Medicine)
Source: Critical Care Medicine - July 19, 2016 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Recognition and Appropriate Treatment of the Acute Respiratory Distress Syndrome Remains Unacceptably Low*
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - July 19, 2016 Category: Emergency Medicine Tags: Editorials Source Type: research

High-Flow Oxygen as Noninvasive Ventilation May Complicate Timely Intubation in Patients With Acute Respiratory Distress Syndrome
No abstract available (Source: Critical Care Medicine)
Source: Critical Care Medicine - July 19, 2016 Category: Emergency Medicine Tags: Online Letters to the Editor Source Type: research

[French data from the Continuing to Confront COPD (C2C) survey].
CONCLUSION: The impact of COPD is markedly underestimated by respondents with COPD despite a high level of symptoms, poor health status and frequent exacerbations as assessed with validated measures. PMID: 27423810 [PubMed - as supplied by publisher] (Source: Revue des Maladies Respiratoires)
Source: Revue des Maladies Respiratoires - July 19, 2016 Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research

Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease
The structural maintenance of chromosomes (SMC) family of proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability. Impairments in chromosome maintenance are linked to rare chromosome breakage disorders. Here, we have identified a chromosome breakage syndrome associated with severe lung disease in early childhood. Four children from two unrelated kindreds died of severe pulmonary disease during infancy following viral pneumonia with evidence of combined T and B cell immunodeficiency. Whole exome sequencing revealed biallelic missense mutations in the NSMCE3 (also known as NDNL2) gene, w...
Source: Journal of Clinical Investigation - July 19, 2016 Category: Biomedical Science Authors: Saskia N. van der Crabben, Marije P. Hennus, Grant A. McGregor, Deborah I. Ritter, Sandesh C.S. Nagamani, Owen S. Wells, Magdalena Harakalova, Ivan K. Chinn, Aaron Alt, Lucie Vondrova, Ron Hochstenbach, Joris M. van Montfrans, Suzanne W. Terheggen-Lagro, Source Type: research

[The role of sex and age as predictors of an apnea and hypopnea index higher than 5/hours in patients with normal body mass index using respiratory polygraphy].
CONCLUSION: Forty-eight point ninety-five percent of normal weight patients in a population at risk had OSAHS defined by an AHI>5/h. The sex and age would be risk predictors in this population and most likely in men. PMID: 27423652 [PubMed - as supplied by publisher] (Source: Medicina Clinica)
Source: Medicina Clinica - July 19, 2016 Category: Journals (General) Tags: Med Clin (Barc) Source Type: research

Thoracic and abdominal aneurysms as incidental findings
Conclusions The majority of patients were male (60%); TAA was the most common type (mean diameter: 4.1 cm), followed by AAA (mean diameter: 4.0 cm) and ATA (mean diameter: 3.9 cm). The most common indication for the CT examination that led to incidental diagnosis of an aneurysm was respiratory symptoms. (Source: Jornal Vascular Brasileiro)
Source: Jornal Vascular Brasileiro - July 19, 2016 Category: Surgery Source Type: research

Use the Lower Limit of Normal, Not 80% Predicted, in Judging Eligibility for Lung Resection
Background: Impaired lung function (LF) is a well-known risk factor for perioperative complications in patients qualified for lung resection surgery. The recent European guidelines recommend using values below 80% predicted as indicating abnormal LF rather than the lower limit of normal (LLN). Objectives: To assess how the choice of a cut-off point (80% predicted vs. LLN at -1.645 SD) affects the incidence of functional disorders and postoperative complications in lung cancer patients referred for lung resection. Methods: Preoperative spirometry and the transfer factor for carbon monoxide (TL,CO) were retrospectively analy...
Source: Respiration - July 19, 2016 Category: Respiratory Medicine Source Type: research

Ethnic differences in resting metabolic rate, respiratory quotient and body temperature: a comparison of Africans and European Australians
Conclusions In this study, SSA had a lower RMR, higher RQ and lower IET relative to EUR Australians. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - July 19, 2016 Category: Nutrition Source Type: research

Exposure to fine particulate matter and hospital admissions due to pneumonia: Effects on the number of hospital admissions and its costs
Conclusion: A 10 µg/m3 decrease in concentration would imply 256 less hospital admissions and savings of approximately R$ 220,000 in a medium-sized city.Resumo Objetivo: como as doenças do aparelho respiratório são importantes causas de internação em crianças, os objetivos deste estudo são estimar o papel da exposição ao particulado fino nas internações por pneumonias e a possível redução do número dessas internações e de seus custos. Método: um estudo ecológico de séries temporais foi desenvolvido com dados de internação por pneumonias em crianças de até 10 anos de idade, residentes em São José ...
Source: Revista da Associacao Medica Brasileira - July 19, 2016 Category: Journals (General) Source Type: research

Incidence of Acute Respiratory Distress Syndrome
To the Editor In a large observational study of the incidence of acute respiratory distress syndrome (ARDS), the diagnosis was made in the analysis phase by a computer algorithm using raw data collected for each component of the Berlin Definition for all study patients with hypoxemia who were breathing with the aid of a ventilator. The authors concluded that ARDS is clinically underrecognized because the computer algorithm diagnosed more patients with ARDS than did clinicians. (Source: JAMA)
Source: JAMA - July 19, 2016 Category: Journals (General) Source Type: research

Incidence of Acute Respiratory Distress Syndrome
To the Editor The article by Dr Bellani and colleagues did not describe the role of the clinicians treating patients with ARDS in the study, in particular whether they knew if their skills diagnosing ARDS were being tested. This is relevant to a conclusion drawn by authors in the discussion section. If clinicians were aware of the study purpose (based on the fact that they were asked about ARDS at 2 separate times in the study), then the conclusion that ARDS might have been underrecognized in the study may not be correct. If physicians were conscious of being evaluated for their diagnostic skills, they would be less likely...
Source: JAMA - July 19, 2016 Category: Journals (General) Source Type: research

Incidence of Acute Respiratory Distress Syndrome
In Reply Drs Siempos and Berlin are concerned that the computer algorithm may have overestimated the incidence of ARDS reported in our study. We used objective data (eg, arterial partial pressure of oxygen to fraction of inspired oxygen ratio, presence of an ARDS risk factor, presence of bilateral infiltrates) that were entered into the database by the investigators in the study intensive care units. If all the criteria for ARDS (as per the Berlin Definition) were met, these patients were coded as having ARDS—this is what was referred to as the “computer algorithm.” We did not set any additional criterion that was no...
Source: JAMA - July 19, 2016 Category: Journals (General) Source Type: research

Incorrect Language and List in the Supplement
This article and its supplement have been corrected online. (Source: JAMA)
Source: JAMA - July 19, 2016 Category: Journals (General) Source Type: research

Endobronchial ultrasound in real life: primary diagnosis and mediastinal staging of lung cancer in patients submitted to thoracic surgery
Since the first articles published for over 10 years ago, endobronchial ultrasound (EBUS) has gained a strong scientific backing and has been incorporated into routine medical practice in pulmonology and thora... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - July 19, 2016 Category: Respiratory Medicine Authors: João Pedro Steinhauser Motta, Axel Tobias Kempa, Alexandre Pinto Cardoso, Marcos Eduardo Paschoal, Ronir Raggio Luiz, José Roberto Lapa e Silva and Franz Stanzel Source Type: research

An imperfect “PAST” Lessons learned from the National Review of Asthma Deaths (NRAD) UK
Asthma deaths are a barometer of the quality of asthma care. The principal care for patients with severe asthma is often a joint partnership between primary and secondary services. Communication between the tw... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2016 Category: Respiratory Medicine Authors: Shuaib Nasser Source Type: research

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague–Dawley rats
We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to S... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2016 Category: Respiratory Medicine Authors: Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G. Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren, Alan Hodgson, Jicheng Gong, Mary P. Ryan, Junfeng (Jim) Zhang, Alexandra Porter, Terry D. Tetley, Andrew Gow… Source Type: research

Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome
Pulmonary thromboembolism (PTE) is a common diagnosis and a leading cause of cardiovascular morbidity and mortality. A growing literature has associated PE with systemic inflammation, and global hyper-coagulab... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2016 Category: Respiratory Medicine Authors: John Zagorski and Jeffrey A. Kline Source Type: research

Airway smooth muscle NOX4 is upregulated and modulates ROS generation in COPD
The burden of oxidative stress is increased in chronic obstructive pulmonary disease (COPD). However, whether the intra-cellular mechanisms controlling the oxidant/anti-oxidant balance in structural airway cel... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2016 Category: Respiratory Medicine Authors: Fay Hollins, Amanda Sutcliffe, Edith Gomez, Rachid Berair, Richard Russell, Cédric Szyndralewiez, Ruth Saunders and Christopher Brightling Source Type: research

Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague –Dawley rats
We examined the potential toxic effects when inhaled in Brown-Norway (BN) rats with a pre-inflammatory state compared to S... (Source: Respiratory Research)
Source: Respiratory Research - July 19, 2016 Category: Respiratory Medicine Authors: Joanna Seiffert, Alison Buckley, Bey Leo, Nicholas G. Martin, Jie Zhu, Ranran Dai, Farhana Hussain, Chang Guo, James Warren, Alan Hodgson, Jicheng Gong, Mary P. Ryan, Junfeng (Jim) Zhang, Alexandra Porter, Terry D. Tetley, Andrew Gow & hellip; Source Type: research

Multiparameter Predictor of Fluid Responsiveness in Cardiac Surgical Patients Receiving Tidal Volumes Less Than 10 mL/kg
Conclusion. While integration of multiple physiologic waveforms as well as ventilator parameters improves the predictability of fluid responsive metrics in the setting of lung-protective ventilation, the composite index may still be of limited predictive value. (Source: Seminars in Cardiothoracic and Vascular Anesthesia)
Source: Seminars in Cardiothoracic and Vascular Anesthesia - July 19, 2016 Category: Anesthesiology Authors: Ikeda, K., Smith, G., Renehan, J., Isbell, J., McMurry, T., Rosner, M., Thiele, R. Tags: Original Research Source Type: research

Predictors of survival in patients with sarcoma admitted to the intensive care unit
Conclusions Our results suggest that patients that are admitted to the ICU for respiratory failure, cardiac arrest, septic shock, acute renal failure or acidosis and also have a high SOFA score with subsequent worsening in the ICU have poor prognosis. Based on the retrospective data which needs further validation we can recommend that judicious approach should be taken in patients with predictors of poor survival before subjecting them to aggressive treatment. (Source: Clinical Sarcoma Research)
Source: Clinical Sarcoma Research - July 19, 2016 Category: Cancer & Oncology Source Type: research

Effect of a two-step hygiene management on the prevention of nosocomial influenza in a season with high influenza activity
Conclusion Discrimination of influenza A from other respiratory infections in elderly hospitalized patients was not possible by clinical characteristics. With regard to hygiene management, the permanent use of surgical masks by hospital staff seems to be effective for prevention of nosocomial infections. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - July 19, 2016 Category: Infectious Diseases Source Type: research

Best Practices for Intrathecal Baclofen Therapy: Screening Test
ConclusionsScreening helps identify appropriate candidates for ITB. (Source: Neuromodulation)
Source: Neuromodulation - July 19, 2016 Category: Neurology Authors: Aaron L. Boster, Susan E. Bennett, Gerald S. Bilsky, Mark Gudesblatt, Stephen F. Koelbel, Maura McManus, Michael Saulino Tags: Review Article Source Type: research

Temporal changes in physiological parameters of systemic inflammatory response syndrome during the three days prior to a diagnosis of sepsis: a case–control study
ConclusionsThe presence of a wound, hypertension or diabetes mellitus, and the use of an invasive medical device may increase the risk of systemic inflammatory response syndrome. Of the physiological parameters examined, heart rate, platelet counts, and blood glucose levels might serve as significant early signs of systemic inflammatory response syndrome. Relevance to clinical practiceCaution should be observed whenever diabetic or hypertension patients develop sudden and persistent hyperglycaemia or tachycardia, and nurses should also be aware of the potential for systemic inflammatory response syndrome in patients with a...
Source: Journal of Clinical Nursing - July 19, 2016 Category: Nursing Authors: HyunSoo Oh, EunKyoung Bae, SeonYoung Lim, JiHye Oh, SunYoung Han, WhaSook Seo Tags: Original Article Source Type: research

Pulse oximetry: an important first step in improving health outcomes, but is of little use if there is no oxygen
According to the most recent Unicef estimates, 5.9 million children under age 5 died in 2015.1 In low-income countries, mortality in early childhood is dominated by prematurity, sepsis, and pneumonia—diseases that frequently result in hypoxemic respiratory failure. Since the introduction of pulse oximetry into clinical practice in the 1980s, pulse oximeters have become ubiquitous in high-income countries and are increasingly used in the diagnosis and management of childhood disease in middle and low-resource settings. There is intuitive appeal of a point-of-care device such as pulse oximetry to detect hypoxaemia, par...
Source: Archives of Disease in Childhood - July 19, 2016 Category: Pediatrics Authors: Moschovis, P. P., Hibberd, P. L. Tags: Editorial Source Type: research

Is asthma overdiagnosed?
Martin Luther likened human reason to a drunken man on horseback, alternately falling off to the left and then to the right.1 The same is true of diagnosing asthma; undoubtedly in the past it was underdiagnosed, but have we gone too far in the opposite direction? The evidence is that we have; for example, in an Australian paper, in which more than 100 children with chronic cough were investigated intensively, including with bronchoscopy (which we do not recommend as a routine diagnostic test!), half were given a diagnosis of asthma prior to investigation; the number actually thought to have asthma had dwindled to 5% at the...
Source: Archives of Disease in Childhood - July 19, 2016 Category: Pediatrics Authors: Bush, A., Fleming, L. Tags: Surgery, Clinical trials (epidemiology), Therapeutic trials, Epidemiologic studies, Editor's choice, Press releases, Immunology (including allergy), TB and other respiratory infections, Drugs: CNS (not psychiatric), Child health, Asthma, Drugs: respirator Source Type: research

When should clinicians suspect group A streptococcus empyema in children? A multicentre case-control study in French tertiary care centres
Conclusions Pleural empyema following varicella or presenting with rash, signs of circulatory failure and leucopenia may be due to GAS. These features should prompt the addition to treatment of an antitoxin drug, such as clindamycin. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 19, 2016 Category: Pediatrics Authors: Bellulo, S., Sommet, J., Levy, C., Gillet, Y., Hees, L., Lorrot, M., Gras-Le-Guen, C., Craiu, I., Dubos, F., Minodier, P., Biscardi, S., Dommergues, M.-A., Bechet, S., Bidet, P., Alberti, C., Cohen, R., Faye, A., for the French Pediatric Infectious Diseas Tags: Immunology (including allergy), Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine) Original article Source Type: research