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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Analysis of Forced Expiratory Flow Signals Using the New Luus–Jaakola Optimization Procedure
Conclusion: The method can be used to estimate FVC by analyzing an incomplete FEFT curve, providing the length of the curve is more than 3 s. Significance: This me- hod can help the subjects who cannot complete the forced expiratory maneuver to provide a reliable estimate of FVC and also can be used to analyze the unacceptable spirometry because of early termination of exhalation. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - May 19, 2015 Category: Biomedical Engineering Source Type: research

“It’s safer to ...” Parent consulting and clinician antibiotic prescribing decisions for children with respiratory tract infections: an analysis across four qualitative studies
Publication date: Available online 16 May 2015 Source:Social Science & Medicine Author(s): Christie Cabral , Patricia J. Lucas , Jenny Ingram , Alastair D. Hay , Jeremy Horwood This paper reports a cross-study analysis of four studies, aiming to understand the drivers of parental consulting and clinician prescribing behaviour when children under 12 years consult primary care with acute respiratory tract infections (RTI). Qualitative data were obtained from three primary studies and one systematic review. Purposeful samples were obtained for (i) a focus group study of parents’ information needs and help seeking;...
Source: Social Science and Medicine - May 19, 2015 Category: Psychiatry & Psychology Source Type: research

Limiting volume with modern ventilators
Conclusions: Modern ventilators have an increasing number of optional settings. These settings may increase the delivered tidal volume and disrupt a low tidal-volume strategy. Recognizing how each setting within a mode affects the type of breath delivered is critical when caring for ventilator-dependent patients. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Wing, T. J., Haan, L., Ashworth, L. J., Anderson, J. Tags: Original Research Source Type: research

Long-acting muscarinic antagonists for the prevention of exacerbations of chronic obstructive pulmonary disease
Exacerbations of chronic obstructive pulmonary disease (COPD) have important consequences for lung function, health status and mortality. Furthermore, they are associated with high economic costs, predominantly related to hospitalization. They are managed acutely with short-acting bronchodilators, systemic corticosteroids or antibiotics; however, a large proportion of COPD exacerbations are unreported and therefore untreated or self-managed. There is evidence to suggest that these unreported exacerbations also have important consequences for health status; therefore, reducing exacerbation risk is an important goal in the m...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Jones, P. W. Tags: Reviews Source Type: research

The efficacy of crizotinib in patients with ALK-positive nonsmall cell lung cancer
Molecular profiling of nonsmall cell lung cancer (NSCLC) contributes to better understanding the different molecular subtypes of this heterogeneous group of diseases. The discovery of oncogenic ALK rearrangements in NSCLC and the subsequent success in their therapeutic targeting with crizotinib reinforces the benefits of a precision approach to systemic anticancer therapy. In addition, the rapid development of crizotinib from first discovery thorough accelerated US Food and Drug Administration approval, and late stage confirmatory clinical trials, exemplifies the success of the drug development strategy of close collaborat...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Pender, A., Popat, S. Tags: Reviews Source Type: research

Targeting the immune system to treat lung cancer: rationale and clinical experience
The use of immunotherapy that harnesses and enhances the innate powers of the immune system to fight cancer cells represents the most promising new cancer treatment approach since the development of the first chemotherapies and, more recently, targeted therapies. Unexpectedly, lung cancer has recently emerged as an exciting new target for immune-based therapies. Several approaches to immunotherapy for lung cancer have shown promise in early clinical trials and in late-phase development. The most advanced strategies can be split into two main categories: therapeutic vaccines and checkpoint inhibitors. At this time of great ...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Guibert, N., Delaunay, M., Mazieres, J. Tags: Reviews Source Type: research

Nintedanib in the treatment of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease that occurs in older adults. The clinical course of IPF is variable and hard to predict in an individual patient. Nintedanib is a tyrosine kinase inhibitor that has recently been approved in the US and European Union for the treatment of IPF. Preclinical studies have shown that nintedanib interferes with processes active in fibrosis such as fibroblast proliferation, migration and differentiation and the secretion of extracellular matrix. The safety and efficacy of nintedanib have been investigated in the phase II TOMORROW trial and in tw...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Mazzei, M. E., Richeldi, L., Collard, H. R. Tags: Reviews Source Type: research

Interstitial lung disease preceding primary biliary cirrhosis in a male patient
Publication date: Available online 18 May 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): I. Franco , A. Dubini , S. Piciucchi , G. Casoni , V. Poletti A 47-year-old male was admitted with subacute onset of dry cough and fever. Chest tomography demonstrated multifocal areas of consolidation and ground glass attenuation. Cytological analysis of bronchoalveolar lavage revealed lymphocytosis and eosinophilia and anatomopathological exam of transbronchial cryobiopsy showed poorly formed non-caseous granulomas associated to interstitial lympho-plasmocitary infiltrate. The diagnosis of idiopathic gra...
Source: Revista Portuguesa de Pneumologia - May 19, 2015 Category: Respiratory Medicine Source Type: research

High-Throughput Hit Screening Cascade to Identify Respiratory Syncytial Virus (RSV) Inhibitors
Respiratory syncytial virus (RSV) infects 99% of children by age 2 years and is a leading cause of serious lower respiratory tract infection (LRTI) and infant hospitalization in the United Kingdom. Identification of efficacious RSV therapeutics has been hindered by the lack of a robust and appropriate primary assay for high-throughput screening (HTS). Here we report an HTS cascade that identified inhibitors of RSV replication using a robust RSV replicon luminescence-reporter assay for the primary campaign. The performance of the assay was consistent and reliable at scale, with Z' of 0.55 ± 0.08 across 150 assay plat...
Source: Journal of Biomolecular Screening - May 19, 2015 Category: Molecular Biology Authors: Plant, H., Stacey, C., Tiong-Yip, C.-L., Walsh, J., Yu, Q., Rich, K. Tags: Original Research Source Type: research

Delaying the widespread emergence of cephalosporin-resistant gonorrhoea: what is the best target?
Neisseria gonorrhoeae is associated with high morbidity worldwide. The emergence of cephalosporin and macrolide resistance represents a grave threat to the control of a disease, which, if untreated, can lead to serious reproductive complications in women, blindness in neonates, facilitated spread of HIV and, in rare cases, life-threatening disseminated infections.1 2 A plenary was convened at the Centers for Disease Control and Prevention's (CDC) sexually transmitted disease (STD) Prevention Conference held in Atlanta, Georgia, 9–12 June 2014, to discuss several key aspects pertaining to this issue. The Scientific Co...
Source: Sexually Transmitted Infections - May 19, 2015 Category: Sexual Medicine Authors: Tuddenham, S., Ghanem, K. G. Tags: Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Ophthalmology, Child health, Inflammation, Respiratory medicine, HIV / AIDS, Gonorrhoea, HIV infections Antimicrobial resistance futures for gonorrhoea Source Type: research

Will targeting oropharyngeal gonorrhoea delay the further emergence of drug-resistant Neisseria gonorrhoeae strains?
Gonorrhoea is an important sexually transmitted infection associated with serious complications and enhanced HIV transmission. Oropharyngeal infections are often asymptomatic and will only be detected by screening. Gonococcal culture has low sensitivity (<50%) for detecting oropharyngeal gonorrhoea, and, although not yet approved commercially, nucleic acid amplification tests (NAAT) are the assay of choice. Screening for oropharyngeal gonorrhoea should be performed in high-risk populations, such as men-who-have-sex-with-men(MSM). NAATs have a poor positive predictive value when used in low-prevalence populations. Gonoco...
Source: Sexually Transmitted Infections - May 19, 2015 Category: Sexual Medicine Authors: Lewis, D. A. Tags: Drugs: infectious diseases, HIV/AIDS, Respiratory medicine, HIV / AIDS, Gonorrhoea, HIV infections, Screening (epidemiology), Screening (public health) Antimicrobial resistance futures for gonorrhoea Source Type: research

Lung ultrasonography: an effective way to diagnose community-acquired pneumonia
Conclusions Lung ultrasonography has a better diagnostic sensitivity and accuracy for diagnosing CAP compared with CXR. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - May 19, 2015 Category: Emergency Medicine Authors: Liu, X.-l., Lian, R., Tao, Y.-k., Gu, C.-d., Zhang, G.-q. Tags: Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research

Assessment of the feasibility of an ultra-low power, wireless digital patch for the continuous ambulatory monitoring of vital signs
Conclusions Overall agreement between digital patch and clinical monitor was satisfactory, as was the efficacy of the system for automatic rejection of invalid data. Wireless monitoring technologies, such as the one tested, may offer clinical value when implemented as part of wider hospital systems that integrate and support existing clinical protocols and workflows. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Hernandez-Silveira, M., Ahmed, K., Ang, S.-S., Zandari, F., Mehta, T., Weir, R., Burdett, A., Toumazou, C., Brett, S. J. Tags: Open access, Medical management, Patient-centred medicine Research Source Type: research

Longitudinal impact of demographic and clinical variables on health-related quality of life in cystic fibrosis
Conclusions Demographic and changes in clinical variables were independently associated with a change in HRQoL over time. Compared with these longitudinal data, cross-sectional data are inadequate when evaluating the relationships between HRQoL domains and key demographic and clinical variables, as they fail to recognise the full impact of the CF disease trajectory and its treatments on quality of life. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Abbott, J., Morton, A. M., Hurley, M. A., Conway, S. P. Tags: Open access, Mental health, Respiratory medicine Research Source Type: research

Work-related allergies to storage mites in Parma (Italy) ham workers
Conclusions Ham processing workers, as well as workers involved in any meat processing work that includes curing, should be informed about the occupational risk of sensitisation to mites. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Tafuro, F., Ridolo, E., Goldoni, M., Montagni, M., Mutti, A., Corradi, M. Tags: Open access, Occupational and environmental medicine, Respiratory medicine Research Source Type: research

The diagnostic accuracy of chest ultrasound for CT-detected radiographic consolidation in hospitalised adults with acute respiratory failure: a systematic review
Conclusions Four small studies suggest ultrasound is highly sensitive and specific for consolidation in ARF, but high risk of bias and concerns about applicability in all studies may have inflated diagnostic accuracy. Further robustly designed studies are needed to define the role of ultrasound in this setting. Trial registration number (CRD42013006472). (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Hew, M., Corcoran, J. P., Harriss, E. K., Rahman, N. M., Mallett, S. Tags: Open access, Evidence based practice, Intensive care, Radiology and imaging, Research methods, Respiratory medicine Source Type: research

subsp in prevention of common infections in healthy children attending day care centers – randomized, double blind, placebo-controlled study
The aim of our study was to investigate the role of Bifidobacterium animalis subsp. lactis (BB-12®) in the prevention of common (gastrointestinal and respiratory) infections in healthy children who attend day care centers. (Source: Clinical Nutrition)
Source: Clinical Nutrition - May 19, 2015 Category: Nutrition Authors: Iva Hojsak, Ana Močić Pavić, Tea Kos, Jelena Dumančić, Sanja Kolaček Tags: Randomized Control Trials Source Type: research

Regulation of cell death by intracellular delivery of nitric oxide to macrophages infected with virulent or avirulent
Macrophages do not readily undergo spontaneous apoptosis, but infection with Mycobacterium tuberculosis (Mtb) may induce cell death in different ways (Divangahi, Behar, & Remold, 2013). Nitric oxide (NO) mediates several innate defence mechanisms against intracellular Mtb, including apoptosis (Chan, Chan, & Schluger, 2001), and is also intrinsically bactericidal (Verma et al., 2013). NO mediates effects of adaptive immunity as indicated by the observation that the inducible nitric oxide synthase gene is strongly induced in macrophages by gamma interferon. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: Rahul Kumar Verma, Amit Misra Source Type: research

Density equalizing mapping of the global tuberculosis research architecture
Tuberculosis belongs to the lung infectious diseases with the highest impact on global burden of disease. Yet there is no concise scientometric study about tuberculosis research. Therefore, the NewQiS project elected this subject as focus of an in depth analysis to perform density equalizing mapping in combination with scientometrics. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: David A. Groneberg, Esther Weber, Alexander Gerber, Axel Fischer, Doris Klingelhoefer, Doerthe Brueggmann Source Type: research

Liposomal delivery of Lipoarabinomannan triggers specific T-cells
Lipoarabinomannan (LAM) is a major cell wall component of Mycobacterium tuberculosis (Mtb). LAM specific human T-lymphocytes release interferon-γ (IFNγ) and have antimicrobial activity against intracellular Mtb suggesting that they contribute to protection. Therefore the induction of LAM-specific memory T-cells is an attractive approach for the design of a new vaccine against tuberculosis. A prerequisite for the activation of LAM-specific T-cells is the efficient uptake and transport of the glycolipid antigen to the CD1 antigen presenting machinery. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: Stephanie Kallert, Sebastian Zenk, Paul Walther, Mark Grieshober, Tanja Weil, Steffen Stenger Tags: Immunological Aspects Source Type: research

The Hispanic health paradox across generations: the relationship of child generational status and citizenship with health outcomes
This study examines immigrant respiratory health disparities among Hispanic children in terms of current asthma, bronchitis, and allergies using an expanded six-group immigrant cohort framework that includes citizenship and the fourth-plus generation. (Source: Public Health)
Source: Public Health - May 19, 2015 Category: Global & Universal Authors: A.J. Balcazar, S.E. Grineski, T.W. Collins Tags: Original Research Source Type: research

SNO-Hb and hypoxic vasodilation [Medical Sciences]
The respiratory system has traditionally been thought of as a two-gas model: hemoglobin (Hb) within red blood cells (RBC) binds oxygen in the lungs, delivers the oxygen to peripheral tissues, and binds carbon dioxide, which is returned to the lungs, released, and expired. However, fine-tuning of the system is required... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 19, 2015 Category: Science Authors: Kulandavelu, S., Balkan, W., Hare, J. M. Tags: Commentaries Source Type: research

Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration.
CONCLUSIONS: Obstructive sleep apnea and adverse respiratory events in the recovery room are harbingers of increased risk for respiratory depression or sedation requiring naloxone after discharge from anesthesia care. Also, patients administered naloxone received more opioids and other sedating medications after discharge from anesthetic care. Our findings suggest that these patients may benefit from more careful monitoring after being discharged from anesthesia care. PMID: 25993390 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - May 19, 2015 Category: Anesthesiology Authors: Weingarten TN, Herasevich V, McGlinch MC, Beatty NC, Christensen ED, Hannifan SK, Koenig AE, Klanke J, Zhu X, Gali B, Schroeder DR, Sprung J Tags: Anesth Analg Source Type: research

Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery: A Retrospective Cohort Study.
CONCLUSIONS: Within the constraints of this analysis that included only 22 affected patients, preoperative aspirin use was not associated with a decreased incidence of ARDS after aortic valve replacement surgery or improved oxygenation. PMID: 25993389 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - May 19, 2015 Category: Anesthesiology Authors: Mazzeffi M, Kassa W, Gammie J, Tanaka K, Roman P, Zhan M, Griffith B, Rock P Tags: Anesth Analg Source Type: research

Ventilatory abnormalities in patients with cystic fibrosis undergoing the submaximal treadmill exercise test
Conclusion: VCAP can be used to analyze ventilatory parameters during exercise. All cardiorespiratory, spirometry, and VCAP variables differed between patients in the CFG and CG before, during, and after exercise. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - May 19, 2015 Category: Respiratory Medicine Authors: Paloma ParazziFernando MarsonMaria RibeiroCelize de AlmeidaLuiz MartinsIlma PaschoalAdyleia ToroCamila ShivinskiJose Ribeiro Source Type: research

The association between antibody levels before and after 7-valent pneumococcal conjugate vaccine immunization and subsequent pneumococcal infection in chronic arthritis patients
Conclusions: Patients with more robust antibody responses after vaccination with pneumococcal conjugate vaccine were less likely to suffer from serious infections. High age and prednisolone at vaccination were associated with putative serious pneumococcal infections in this cohort.Trial registration numberEudraCT EU 2007-006539-29 and NCT00828997. Registered 23 January 2009. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 19, 2015 Category: Rheumatology Authors: Johanna NagelPierre GeborekTore SaxneGöran JönssonMartin EnglundIngemar PeterssonJan-Åke NilssonLennart TruedssonMeliha Kapetanovic Source Type: research

Qing-Yi decoction in participants with severe acute pancreatitis: a randomized controlled trial
Conclusions: QYD could restore gastrointestinal motility to normal and reduce the infection rates in the SAP patients who completed a full course of QYD treatment according to per protocol analysis. (Source: Chinese Medicine)
Source: Chinese Medicine - May 19, 2015 Category: Complementary Medicine Authors: Weiwei ChenXiaonan YangLei HuangPing XueMeihua WanJia GuoLin ZhuTao JinZongwen HuangGuangyuan ChenWenfu TangQing Xia Source Type: research

Bronchiolitis obliterans organizing pneumonia as an indicator of B-cell chronic leukemia malignancy progression - a case report.
We present a case of 65-year old gentlemen, diagnosed 8 months earlier with B-cell chronic lymphocytic leukemia, who presented symptoms of long lasting severe pneumonia with no significant reaction to antibiotics. Chest CT scan showed well-localized consolidation with ground glass opacities and some air bronchogram, suggesting bacterial or atypical etiology of infectious disease. All testing for infectious factors came back negative. Due to radiological progression of parenchymal consolidation despite two intravenous antibiotics open lung biopsy was performed. The histologic examination of lung specimen reveled structures ...
Source: Pneumonologia i Alergologia Polska - May 19, 2015 Category: Respiratory Medicine Authors: Polaczek MM, Zych J, Opoka L, Maksymiuk B, Roszkowski-Śliż K Tags: Pneumonol Alergol Pol Source Type: research

Association between asthma control test, pulmonary function tests and non-specific bronchial hyperresponsiveness in assessing the level of asthma control.
CONCLUSION: In determining the most accurate level of asthma control it is reasonable to use an ACT in conjunction with BHR, which provides more accurate assessment of bronchial inflammation than spirometry alone. PMID: 25985789 [PubMed - as supplied by publisher] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - May 19, 2015 Category: Respiratory Medicine Authors: Grzelewska-Rzymowska IF, Mikołajczyk J, Kroczyńska-Bednarek J, Górski P Tags: Pneumonol Alergol Pol Source Type: research

Pulmonary presentation of Toxocara sp. infection in children.
CONCLUSION: The pulmonary lesions in small children with high eosinophilia and hyperimmunoglobulinemia E could be related to toxocariasis and for this reason they are eligible to undergo therapy with prolonged observation for several months, rather than start invasive malignancy investigations. PMID: 25985788 [PubMed - as supplied by publisher] (Source: Pneumonologia i Alergologia Polska)
Source: Pneumonologia i Alergologia Polska - May 19, 2015 Category: Respiratory Medicine Authors: Mazur-Melewska K, Jonczyk-Potoczna K, Kemnitz P, Mania A, Figlerowicz M, Służewski W Tags: Pneumonol Alergol Pol Source Type: research

A psychological intervention for smoking cessation delivered as treatment for smokers with chronic obstructive pulmonary disease: Multiple needs of a complex group and recommendations for novel service development.
Abstract This pilot study investigated the benefits of adjunctive psychological intervention for smokers accessing standard smoking cessation interventions. Chronic obstructive pulmonary disease (COPD) smokers attending a smoking cessation service were offered up to 12 adjunctive clinical psychology sessions. Baseline data included demographics, smoking history, and disease severity. Outcomes included attendance and quit rate. In all, 59 patients with moderate COPD were referred. Of the 20 patients who attended training sessions, 7 (35%) were relapse prevention referrals and 13 (65%) were current smokers. Of the se...
Source: Chronic Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Yap SY, Lunn S, Pang E, Croft C, Stern M Tags: Chron Respir Dis Source Type: research

Serum urate and obstructive sleep apnoea in severe obesity.
This study investigated whether OSA was associated with serum urate in severe obesity and whether continuous positive airway pressure (CPAP) treatment was associated with a fall in urate. Severely obese subjects without known OSA or gout were recruited. Baseline assessments included urate, metabolic parameters, spirometry and overnight polysomnography. OSA patients were initially naive to treatment and were offered CPAP. At follow-up, change in urate was compared between CPAP-treated and non-CPAP-treated subjects. A high urate was defined as greater than the median. Logistic regression was performed to identify association...
Source: Chronic Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Seetho IW, Parker RJ, Craig S, Duffy N, Hardy KJ, Wilding JP, Goodson NJ Tags: Chron Respir Dis Source Type: research

Noninvasive Ventilation in Mustard Airway Diseases.
CONCLUSIONS: NIV can be used as an effective new palliative method in the treatment of mustard airway disorders. Subjects with very severe and severe disease benefitted differently from NIV. PMID: 25989812 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2015 Category: Respiratory Medicine Authors: Aliannejad R, Peyman M, Ghanei M Tags: Respir Care Source Type: research

Plan to Have No Unplanned: A Collaborative, Hospital-Based Quality-Improvement Project to Reduce the Rate of Unplanned Extubations in the Pediatric ICU.
CONCLUSIONS: A targeted approach based on unit-specific risk factors is most effective in quality-improvement projects. A specific policy for sedation and weaning can be very helpful in managing intubated patients and preventing unintended harm. PMID: 25989811 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 19, 2015 Category: Respiratory Medicine Authors: Tripathi S, Nunez DJ, Katyal C, Ushay HM Tags: Respir Care Source Type: research

Systemic Inflammatory Marker CRP Was Better Predictor of Readmission for AECOPD Than Sputum Inflammatory Markers.
CONCLUSION: Systemic inflammatory marker CRP was a better predictor of readmission than sputum inflammatory markers. CAT score and age were also useful to predict readmission. PMID: 26002550 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - May 19, 2015 Category: Respiratory Medicine Authors: Jing Z, Chun C, Ning S, Hong Z, Bei H, Wan-Zhen Y Tags: Arch Bronconeumol Source Type: research

Antimicrobial peptide resistance in Neisseria meningitidis.
This article reviews the current knowledge about AMP resistance mechanisms employed by N. meningitidis. Two major resistance mechanisms employed by meningococci are the constitutive modification of the lipid A head groups of lipooligosaccharides by phosphoethanolamine and the active efflux pump mediated excretion of AMPs. Other factors influencing AMP resistance, such as the major porin PorB, the pilin biogenesis apparatus, and capsular polysaccharides, have also been identified. Even with an inherently high intrinsic resistance, several AMP resistance determinants can be further induced upon exposure to AMPs. Many well-ch...
Source: Biochimica et Biophysica Acta - May 19, 2015 Category: Biochemistry Authors: Tzeng YL, Stephens DS Tags: Biochim Biophys Acta Source Type: research

Unbalanced acetylcholinesterase activity in larynx squamous cell carcinoma.
Abstract Previous reports have demonstrated that a non-neuronal cholinergic system is expressed aberrantly in airways. A proliferative effect is exerted directly by cholinergic agonists through the activation of nicotinic and muscarinic receptors. In cancer, particularly those related with smoking, the mechanism through which tumour cells respond to aberrantly activated cholinergic signalling is a key question. Fifty paired pieces of larynx squamous cell carcinoma and adjacent non-cancerous tissue were compared in terms of their acetylcholinesterase activity (AChE). The AChE activity in non-cancerous tissues (0.248...
Source: International Immunopharmacology - May 19, 2015 Category: Allergy & Immunology Authors: Castillo-González AC, Pelegrín-Hernández JP, Nieto-Cerón S, Madrona AP, Noguera JA, López-Moreno MF, Rodríguez-López JN, Vidal CJ, Hellín-Meseguer D, Cabezas-Herrera J Tags: Int Immunopharmacol Source Type: research

Asthma exacerbation and viral infection in adult patients, Brazil.
CONCLUSION: Viral infections represent an important trigger for exacerbation of asthma symptoms. Development of effective treatments or vaccines to prevent such infections would have a significant impact on reducing the burden of asthma in adults. PMID: 26001979 [PubMed - as supplied by publisher] (Source: Braz J Infect Dis)
Source: Braz J Infect Dis - May 19, 2015 Category: Infectious Diseases Authors: Silva RC, Couceiro JN, Câmara FP, Valle S, Santos N Tags: Braz J Infect Dis Source Type: research