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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

miR-210 promotes IPF fibroblast proliferation in response to hypoxia
Idiopathic pulmonary fibrosis (IPF) is characterized by the relentless spread of fibroblasts from scarred alveoli into adjacent alveolar units, resulting in progressive hypoxia and death by asphyxiation. Although hypoxia is a prominent clinical feature of IPF, the role of hypoxia as a driver of the progressive fibrotic nature of the disease has not been explored. Here, we demonstrate that hypoxia robustly stimulates the proliferation of IPF fibroblasts. We found that miR-210 expression markedly increases in IPF fibroblasts in response to hypoxia and that knockdown of miR-210 decreases hypoxia-induced IPF fibroblast prolife...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Bodempudi, V., Hergert, P., Smith, K., Xia, H., Herrera, J., Peterson, M., Khalil, W., Kahm, J., Bitterman, P. B., Henke, C. A. Tags: CALL FOR PAPERS Source Type: research

Severity of neonatal hyperoxia determines structural and functional changes in developing mouse airway
Wheezing is a major long-term respiratory morbidity in preterm infants with and without bronchopulmonary dysplasia. We hypothesized that mild vs. severe hyperoxic exposure in neonatal mice differentially affects airway smooth muscle hypertrophy and resultant airway reactivity. Newborn mice were exposed to 7 days of mild (40% oxygen) or severe (70% oxygen) hyperoxia vs. room air controls. Respiratory system resistance (Rrs), compliance (Crs), and airway reactivity were measured 14 days after oxygen exposure ended under ketamine/xylazine anesthesia. Baseline Rrs increased and Crs decreased in both treatment groups. Methachol...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Wang, H., Jafri, A., Martin, R. J., Nnanabu, J., Farver, C., Prakash, Y. S., MacFarlane, P. M. Tags: ARTICLES Source Type: research

In situ determination of alveolar septal strain, stress and effective Young's modulus: an experimental/computational approach
Alveolar septa, which have often been modeled as linear elements, may distend due to inflation-induced reduction in slack or increase in tissue stretch. The distended septum supports tissue elastic and interfacial forces. An effective Young's modulus, describing the inflation-induced relative displacement of septal end points, has not been determined in situ for lack of a means of determining the forces supported by septa in situ. Here we determine such forces indirectly according to Mead, Takishima, and Leith's classic lung mechanics analysis (J Appl Physiol 28: 596–608, 1970), which demonstrates that septal connect...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Perlman, C. E., Wu, Y. Tags: ARTICLES Source Type: research

Impact of a functional polymorphism in the PAR-1 gene promoter in COPD and COPD exacerbations
Proteinase-activated receptor-1 (PAR-1) plays a key role in mediating the interplay between coagulation and inflammation in response to injury. The aim of this study was to investigate the role of the promoter single-nucleotide polymorphism (SNP) rs2227744G>A in modulating PAR-1/F2R gene expression in the context of chronic obstructive pulmonary disease (COPD) and COPD exacerbations. The function of the rs2227744G>A SNP was investigated by using reporter gene assays. The frequency of the polymorphism in the UK population was assessed by genotyping 8,579 healthy individuals from the Whitehall II and English Longitudin...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Plate, M., Lawson, P. J., Hill, M. R., Quint, J. K., Kumari, M., Laurent, G. J., Wedzicha, J. A., Chambers, R. C., Hurst, J. R. Tags: ARTICLES Source Type: research

Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling
Pulmonary artery smooth muscle cell (PASMC) proliferation plays a fundamental role in the vascular remodeling seen in pulmonary hypertensive diseases associated with hypoxia. Arginase II, an enzyme regulating the first step in polyamine and proline synthesis, has been shown to play a critical role in hypoxia-induced proliferation of human PASMC (hPASMC). In addition, there is evidence that patients with pulmonary hypertension have elevated levels of arginase in the vascular wall. Resveratrol, a natural polyphenol found in red wine and grape skins, has diverse biochemical and physiological actions including antiproliferativ...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Chen, B., Xue, J., Meng, X., Slutzky, J. L., Calvert, A. E., Chicoine, L. G. Tags: ARTICLES Source Type: research

CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke
Despite extensive research, the pathogenesis of cigarette smoking (CS)-associated emphysema remains incompletely understood, thereby impeding development of novel therapeutics, diagnostics, and biomarkers. Here, we report a novel paradigm potentially involved in the development of epithelial death and tissue loss in CS-associated emphysema. After prolonged exposure of CS, CCN1 cleavage was detected both in vitro and in vivo. Full-length CCN1 (flCCN1) was secreted in an exosome-shuttled manner, and secreted plasmin converted flCCN1 to cleaved CCN1 (cCCN1) in extracellular matrix. Interestingly, exosome-shuttled flCCN1 facil...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Moon, H.-G., Kim, S.-H., Gao, J., Quan, T., Qin, Z., Osorio, J. C., Rosas, I. O., Wu, M., Tesfaigzi, Y., Jin, Y. Tags: ARTICLES Source Type: research

Growth of alveoli during postnatal development in humans based on stereological estimation
Alveolarization in humans and nonhuman primates begins during prenatal development. Advances in stereological counting techniques allow accurate assessment of alveolar number; however, these techniques have not been applied to the developing human lung. Based on the recent American Thoracic Society guidelines for stereology, lungs from human autopsies, ages 2 mo to 15 yr, were fractionated and isometric uniform randomly sampled to count the number of alveoli. The number of alveoli was compared with age, weight, and height as well as growth between right and left lungs. The number of alveoli in the human lung increased expo...
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Herring, M. J., Putney, L. F., Wyatt, G., Finkbeiner, W. E., Hyde, D. M. Tags: ARTICLES Source Type: research

Exposure of airway smooth muscle cells to cigarette smoke extract
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Hershenson, M. B., Chung, Y. Tags: LETTERS TO THE EDITOR Source Type: research

Response to letter by Dr. Marc Hershenson (exposure of airway smooth muscle cells to cigarette smoke extract)
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - August 15, 2014 Category: Respiratory Medicine Authors: Aravamudan, B., Delmotte, P., Thompson, M., Vassallo, R., Sieck, G. C., Pabelick, C. M., Prakash, Y. S. Tags: LETTERS TO THE EDITOR Source Type: research

Effects of elevated oxygen and carbon dioxide partial pressures on respiratory function and cognitive performance
Hyperoxia during diving has been suggested to exacerbate hypercapnic narcosis and promote unconsciousness. We tested this hypothesis in male volunteers (12 at rest, 10 at 75 W cycle ergometer exercise) breathing each of four gases in a hyperbaric chamber. Inspired Po2 (PiO2) was 0.21 and 1.3 atmospheres (atm) without or with an individual subject's maximum tolerable inspired CO2 (PiO2 = 0.055–0.085 atm). Measurements included end-tidal CO2 partial pressure (PetCO2), rating of perceived discomfort (RPD), expired minute ventilation (Ve), and cognitive function assessed by auditory n-back test. The most prominent findin...
Source: Journal of Applied Physiology - August 15, 2014 Category: Physiology Authors: Gill, M., Natoli, M. J., Vacchiano, C., MacLeod, D. B., Ikeda, K., Qin, M., Pollock, N. W., Moon, R. E., Pieper, C., Vann, R. D. Tags: ARTICLES Source Type: research

Combined submandibular gland flap and sternocleidomastoid musculocutaneous flap for postoperative reconstruction in older aged patients with oral cavity and oropharyngeal cancers
Conclusions: This combined reconstruction technique enables appropriate restoration of oral function, facial aesthetics and improved quality of life. Further, this technique has several advantages: it is easier to perform, reduces operation time and surgical risk, causes less surgical injury, and has minor impact on contour. The technique provides a new and safe reconstruction option for older aged patients with oral cavity and oropharyngeal cancers. (Source: World Journal of Surgical Oncology)
Source: World Journal of Surgical Oncology - August 15, 2014 Category: Cancer & Oncology Authors: Xiangmin ZhangFolin LiuXiaolin LanKeqing LuoShaojin Li Source Type: research

Intrinsic aerobic capacity impacts susceptibility to acute high-fat diet-induced hepatic steatosis
Aerobic capacity/fitness significantly impacts susceptibility for fatty liver and diabetes, but the mechanisms remain unknown. Herein, we utilized rats selectively bred for high (HCR) and low (LCR) intrinsic aerobic capacity to examine the mechanisms by which aerobic capacity impacts metabolic vulnerability for fatty liver following a 3-day high-fat diet (HFD). Indirect calorimetry assessment of energy metabolism combined with radiolabeled dietary food was employed to examine systemic metabolism in combination with ex vivo measurements of hepatic lipid oxidation. The LCR, but not HCR, displayed increased hepatic lipid accu...
Source: AJP: Endocrinology and Metabolism - August 15, 2014 Category: Endocrinology Authors: Matthew Morris, E., Jackman, M. R., Johnson, G. C., Liu, T.-W., Lopez, J. L., Kearney, M. L., Fletcher, J. A., Meers, G. M. E., Koch, L. G., Britton, S. L., Scott Rector, R., Ibdah, J. A., MacLean, P. S., Thyfault, J. P. Tags: Articles Source Type: research

Notes from the field: hospitalizations for respiratory disease among unaccompanied children from central america - multiple States, june-july 2014.
Abstract During October 2013-June 2014, approximately 54,000 unaccompanied children, mostly from the Central American countries of El Salvador, Guatemala, and Honduras, were identified attempting entry into the United States from Mexico, exceeding numbers reported in previous years. Once identified in the United States, U.S. Customs and Border Protection, an agency of the U.S. Department of Homeland Security, processes the unaccompanied children and transfers them to the Office of Refugee Resettlement (ORR), an office of the Administration for Children and Families, U.S. Department of Health and Human Services. ORR...
Source: MMWR Morb Mortal Wkl... - August 15, 2014 Category: Epidemiology Authors: Nyangoma EN, Arriola CS, Hagan J, Socias C, Tomczyk S, Watkins LF, Westercamp M, Kim C, Epidemic Intelligence Service, CDC Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices (ACIP) - United States, 2014-15 Influenza Season.
This report updates the 2013 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding use of seasonal influenza vaccines. Updated information for the 2014-15 influenza season includes 1) antigenic composition of U.S. seasonal influenza vaccines; 2) vaccine dose considerations for children aged 6 months through 8 years; and 3) a preference for the use, when immediately available, of live attenuated influenza vaccine (LAIV) for healthy children aged 2 through 8 years, to be implemented as feasible for the 2014-15 season but not later than the 2015-16 season. Information regarding issues related to...
Source: MMWR Morb Mortal Wkl... - August 15, 2014 Category: Epidemiology Authors: Grohskopf LA, Olsen SJ, Sokolow LZ, Bresee JS, Cox NJ, Broder KR, Karron RA, Walter EB, Influenza Division, National Center for Immunization and Respiratory Diseases, CDC Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Role of Autonomic Reflex Arcs in Cardiovascular Responses to Air Pollution Exposure.
Abstract The body responds to environmental stressors by triggering autonomic reflexes in the pulmonary receptors, baroreceptors, and chemoreceptors to maintain homeostasis. Numerous studies have shown that exposure to various gases and airborne particles can alter the functional outcome of these reflexes, particularly with respect to the cardiovascular system. Modulation of autonomic neural input to the heart and vasculature following direct activation of sensory nerves in the respiratory system, elicitation of oxidative stress and inflammation, or through other mechanisms is one of the primary ways that exposure ...
Source: Cardiovascular Toxicology - August 15, 2014 Category: Cardiology Authors: Perez CM, Hazari MS, Farraj AK Tags: Cardiovasc Toxicol Source Type: research

Sleep-disordered Breathing in Pregnancy.
Authors: PMID: 25127314 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary arteriovenous malformations in the setting of pulmonary amyloidosis.
PMID: 25127313 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Patel UB, Kadoch MA, Jacobi AH Tags: Am J Respir Crit Care Med Source Type: research

Small lesion, severe consequences. An intriguing ventilation-perfusion scintigraphy.
PMID: 25127312 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: De Raedt N, Gheysens O, Nackaerts K, Dooms C, De Ruysscher D, Deroose CM Tags: Am J Respir Crit Care Med Source Type: research

Reply: inhaled antibiotics or inhaled hazard?
PMID: 25127311 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Palmer LB, Smaldone GC Tags: Am J Respir Crit Care Med Source Type: research

Inhaled antibiotics or inhaled hazard?
PMID: 25127310 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Hurley JC Tags: Am J Respir Crit Care Med Source Type: research

Asthmatic and normal respiratory epithelial cells respond differently to mechanical apical stress.
PMID: 25127309 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Grainge C, Dennison P, Lau L, Davies D, Howarth P Tags: Am J Respir Crit Care Med Source Type: research

Insulin resistance, puberty, and nonatopic asthma in adolescent girls.
PMID: 25127308 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Kozyrskyj AL, Zeng Y, Saurek-Aleksandrovska N, Sellers EA, Ramsey CD, Becker AB Tags: Am J Respir Crit Care Med Source Type: research

Osteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthma.
PMID: 25127307 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M Tags: Am J Respir Crit Care Med Source Type: research

In vivo x-ray imaging reveals improved airway surface hydration after a therapy designed for cystic fibrosis.
PMID: 25127306 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Morgan KS, Donnelley M, Farrow N, Fouras A, Yagi N, Suzuki Y, Takeuchi A, Uesugi K, Boucher RC, Siu KK, Parsons DW Tags: Am J Respir Crit Care Med Source Type: research

Improvement of sinus disease in cystic fibrosis with ivacaftor therapy.
PMID: 25127305 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Hayes D, McCoy KS, Sheikh SI Tags: Am J Respir Crit Care Med Source Type: research

Measuring mucociliary transport and mucus properties in multiple regions of airway epithelial surfaces helps clarify cystic fibrosis defects.
PMID: 25127304 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Wine JJ Tags: Am J Respir Crit Care Med Source Type: research

Propensity-matching analysis is not straightforward.
PMID: 25127303 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Chevret S Tags: Am J Respir Crit Care Med Source Type: research

ICU-acquired Weakness, Morbidity, and Death.
PMID: 25127302 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Herridge MS, Batt J, Santos CD Tags: Am J Respir Crit Care Med Source Type: research

The child is father of the man?
PMID: 25127301 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Postma DS, Koppelman GH Tags: Am J Respir Crit Care Med Source Type: research

New asthma biomarkers: shorter telomeres, longer disease?
PMID: 25127300 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Guerra S Tags: Am J Respir Crit Care Med Source Type: research

Emphysema genetics. Location, location, location!
PMID: 25127299 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 15, 2014 Category: Respiratory Medicine Authors: Pillai SG Tags: Am J Respir Crit Care Med Source Type: research

Percutaneous Transluminal Angioplasty for Symptomatic Pulmonary Stenosis in Takayasu Arteritis.
CONCLUSION: The study showed that PTA improved subjective symptoms and objective variables of the patients with symptomatic pulmonary stenosis in TA, with an acceptable mortality. PTA may be a promising therapeutic strategy for symptomatic pulmonary stenosis in TA. PMID: 25128508 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2014 Category: Rheumatology Authors: Dong H, Jiang X, Peng M, Zou Y, Guan T, Zhang H, Song L, Wu H, Yang Y, Gao R Tags: J Rheumatol Source Type: research

Infections Increase Risk of Arterial and Venous Thromboses in Danish Patients with Systemic Lupus Erythematosus: 5102 Patient-years of Followup.
CONCLUSION: The temporal associations observed in this study indicate that infections could be risk factors for arterial or venous thromboses in patients with SLE, although causality was not addressed by this study. PMID: 25128505 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - August 15, 2014 Category: Rheumatology Authors: Baronaite Hansen R, Jacobsen S Tags: J Rheumatol Source Type: research