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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Relationship between radiological (X‐ray/HRCT), spirometric, and clinical findings in dental technicians’ pneumoconiosis
ConclusionsWe believe that a combined approach including spirometry, CXR, and HRCT modalities should be employed in demonstrating respiratory disorders associated with exposure to inorganic dusts in dental technicians. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 11, 2014 Category: Respiratory Medicine Authors: Serdar Berk, Derya Ozdemir Dogan, Cesur Gumus, Ibrahim Akkurt Tags: Original Article Source Type: research

Non‐disseminated histoplasmosis of the trachea
We report the case of a 68‐year‐old female with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough, and subjective throat hoarseness and fullness. Chest CT demonstrated no tracheal findings. Bronchoscopy found mucosal irregularity, nodularity, and vesicular regions in the proximal trachea extending seven centimeters distal to the vocal cords. Also seen was an edematous, exudative left vocal cord with polyps and an ulcerative lesion. Silver staining and culture and wash of the tracheal biopsy revealed Histoplasma capsulatum. She was treated wit...
Source: The Clinical Respiratory Journal - July 11, 2014 Category: Respiratory Medicine Authors: Nicholas Bhojwani, Jason Brett Hartman, David C. Taylor, Mark Herbert, Michael Corriveau Tags: Other Source Type: research

Early non‐invasive ventilation treatment for respiratory failure due to severe community acquired pneumonia
ConclusionsSuccessful treatment is strongly related to less severe illness as well as to a good initial and sustained response to medical therapy and NIV treatment. Constant monitoring of these patients is mandatory. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 11, 2014 Category: Respiratory Medicine Authors: Nicolini Antonello, Ferraioli Gianluca, Ferrari‐Bravo Maura, Barlascini Cornelius, Santo Mario, Ferrera Lorenzo Tags: Original Article Source Type: research

Syncope Paradox in the Outcome of Patients with Pulmonary Thromboembolism: Short‐Term and Mid‐Term Outcome
ConclusionAmong PTE patients in our registry, 11.1% presented with syncope. Relationship between syncope and 30‐day adverse events and mortality remained non‐significant after adjustments for other factors. However, in mid‐term follow‐up, patients with syncope were significantly at decreased risk of mortality compared to those without syncope. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - July 11, 2014 Category: Respiratory Medicine Authors: Seyyed‐reza Seyyedi, Yaser Jenab, Masoumeh Lotfi Tokaldany, Shapoor Shirani, Saeed Sadeghian, Arash Jalali Tags: Original Article Source Type: research

Respiratory bronchiolitis-interstitial lung disease
Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) is a rare, mild inflammatory pulmonary disorder that occurs almost exclusively in current or former heavy smokers, usually between the third and sixth decades, most likely with no gender predilection. The onset is usually insidious with exertional dyspnea and persistent cough, which may be non-productive, developing over a course of weeks or months. RB-ILD may also be diagnosed in asymptomatic patients with functional impairment and chest radiograph or high-resolution computed tomography (HRCT) abnormalities. Histologically, RB-ILD is characterized by ...
Source: Orphanet Journal of Rare Diseases - July 11, 2014 Category: Internal Medicine Authors: Alicja SieminskaKrzysztof Kuziemski Source Type: research

ENaC Activity and Expression is Decreased in the Lungs of Protein Kinase C-α Knockout Mice.
Abstract We used a PKC-α knockout model to investigate the regulation of alveolar ENaC by PKC. Primary alveolar type II (ATII) cells were subjected to cell-attached patch clamp. In the absence of PKC-α, the open probability (Po) of ENaC was decreased by half compared to wildtype mice. The channel density (N) was also reduced in the knockout mice. Using in-vivo biotinylation, membrane localization of all three ENaC subunits (α, β, and γ) was decreased in the PKC-α knockout lung, compared to the wildtype. Confocal microscopy of lung slices, showed elevated levels of reactive oxygen species (ROS) in the lungs of...
Source: Am J Physiol Lung Ce... - July 11, 2014 Category: Respiratory Medicine Authors: Eaton AF, Yue Q, Eaton DC, Bao HF Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Fibroblasts That Resist Cigarette Smoke-induced Senescence Acquire Pro-fibrotic Phenotypes.
Conclusions: Extended exposure to CSE might induce two different fibroblast phenotypes, a senescent and a pro-fibrotic phenotype. The fibroblasts that resist CSE-induced cellular senescence may contribute to the pathogenesis of IPF and could contribute to fibrotic lesions in COPD acting through a TGF-β1 mediated pathway. In contrast, the senescent cells may contribute to the pathogenesis of emphysema. PMID: 25015975 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 11, 2014 Category: Respiratory Medicine Authors: Kanaji N, Basma H, Nelson AJ, Farid M, Sato T, Nakanishi M, Wang X, Michalski J, Li Y, Gunji Y, Feghali-Bostwick CA, Liu X, Rennard SI Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

α-Tocopherol Supplementation of Allergic Female Mice Inhibits Development of CD11c+CD11b+ Dendritic Cells in Utero and Allergic Inflammation in Neonates.
In conclusion, maternal supplementation with α-tocopherol reduced fetal development of subsets of dendritic cells that are critical for allergic responses and reduced development of allergic responses in pups from allergic mothers. These results have implications for supplementation of allergic mothers with α-tocopherol. PMID: 25015974 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 11, 2014 Category: Respiratory Medicine Authors: Abdala-Valencia H, Berdnikovs S, Soveg F, Cook-Mills JM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Acinetobacter guangdongensis sp. nov., isolated from abandoned lead-zinc ore.
Abstract A Gram-stain-negative, non-motile bacterial strain designated 1NM-4T was isolated from an abandoned lead-zinc ore mine site in Mei County, Meizhou, Guangdong Province, South China. The isolate was light yellow, strictly aerobic, oxidase-negative and catalase-positive. Phylogenetic analyses based on 16S rRNA gene, rpoB gene and gyrB gene sequences with DNA-DNA hybridization values less than 70 % revealed that strain 1NM-4T belongs to the genus Acinetobacter and may represent a novel species. The major respiratory quinone is ubiquinone 9 (Q-9) and the major cellular fatty acids consist of C18:1 ω9c, C16:1 ...
Source: International Journal of Systematic and Evolutionary Microbiology - July 11, 2014 Category: Microbiology Authors: Feng GD, Yang SZ, Wang YH, Deng MR, Zhu HH Tags: Int J Syst Evol Microbiol Source Type: research

Idiomarina planktonica sp. nov., isolated from a saline lake in Qinghai, China.
Abstract A Gram-negative bacterium, strain TS-T11T, was isolated from Tuosu Lake, a saline lake (salinity 5.4 %, w/w) in Qaidam basin, Qinghai province, China. Its taxonomic position was determined by using a polyphasic approach. Cells of strain TS-T11T were non-spore-forming rods, 0.6-0.8 μm wide and 0.8-2.2 μm long, and motile by means of a single polar flagellum. Strain TS-T11T was strictly heterotrophic and aerobic. Catalase- and oxidase-positive. Growth was observed in the presence of 0.5-11.0 % (w/v) NaCl (optimum, 4.0-6.0 %) and at 4-40 °C (optimum, 30-35 °C) and pH 6.0-10.5 (optimum, pH 7.5-8.5). Strain...
Source: International Journal of Systematic and Evolutionary Microbiology - July 11, 2014 Category: Microbiology Authors: Zhong ZP, Liu Y, Liu HC, Wang F, Song L, Liu ZP Tags: Int J Syst Evol Microbiol Source Type: research

Heart rate variability is augmented in patients with positional obstructive sleep apnea, but only supine LF/HF index correlates with its severity.
CONCLUSIONS: SDB augments autonomic tone in patients with p-OSA, but only LF/HF correlates with its severity and might be used as a screening tool in the future. On the contrary, parasympathetic tone, as reflected by HF, remains constant in both periods. PMID: 25012091 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 11, 2014 Category: Sleep Medicine Authors: Flevari A, Vagiakis E, Zakynthinos S Tags: Sleep Breath Source Type: research

The effects of epidural/spinal opioids in labour analgesia on neonatal outcomes: a meta-analysis of randomized controlled trials.
CONCLUSION: The common doses of fentanyl and sufentanil used with an epidural/spinal technique in labour analgesia are safe for neonates up to 24 hr after delivery. In future studies, more attention should be paid to the long-term side effects in neonates. PMID: 25011701 [PubMed - as supplied by publisher] (Source: Canadian Journal of Anaesthesia)
Source: Canadian Journal of Anaesthesia - July 11, 2014 Category: Anesthesiology Authors: Wang K, Cao L, Deng Q, Sun LQ, Gu TY, Song J, Qi DY Tags: Can J Anaesth Source Type: research

Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway.
In conclusion, phasic EMGGG had little effect on NED. This finding suggests that individual differences in phasic EMGGG activation do not likely explain the variability in NED found among OSA patients. PMID: 25020212 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - July 11, 2014 Category: Respiratory Medicine Authors: Genta PR, Owens RL, Edwards BA, Sands SA, Eckert DJ, Butler JP, Loring SH, Malhotra A, Jackson AC, White DP, Wellman A Tags: Respir Physiol Neurobiol Source Type: research

Indications for Active Case Searches and Intravenous Alpha-1 Antitrypsin Treatment for Patients With Alpha-1 Antitrypsin Deficiency Chronic Pulmonary Obstructive Disease: An Update.
Abstract The effect of hereditary alpha-1 antitrypsin (AAT) deficiency can manifest clinically in the form of chronic obstructive pulmonary disease (COPD). AAT deficiency (AATD) is defined as a serum concentration lower than 35% of the expected mean value or 50mg/dl (determined by nephelometry). It is associated in over 95% of cases with Pi*ZZ genotypes, and much less frequently with other genotypes resulting from combinations of Z, S, rare and null alleles. A systematic qualitative review was made of 107 articles, focusing mainly on an active search for AATD in COPD patients and intravenous (iv) treatment with AAT...
Source: Archivos de Bronconeumologia - July 11, 2014 Category: Respiratory Medicine Authors: Casas F, Blanco I, Martínez MT, Bustamante A, Miravitlles M, Cadenas S, Hernández JM, Lázaro L, Rodríguez E, Rodríguez-Frías F, Torres M, Lara B Tags: Arch Bronconeumol Source Type: research

Resistance to First-Line Antituberculosis Drugs in Spain, 2010-2011. RETUBES Study.
CONCLUSIONS: The rate of initial isoniazid resistance is greater than estimated, probably due to the increase in immigration during recent years, suggesting that systematic national monitoring is required. Immigrants and those who cohabit in groups have a higher risk of isoniazid resistance. PMID: 25027066 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 11, 2014 Category: Respiratory Medicine Authors: Blanquer R, Rodrigo T, Casals M, Ruiz Manzano J, García-García JM, Calpe JL, Valencia E, Pascual T, Mir I, Jiménez MA, Cañas F, Vidal R, Penas A, Caylà JA, Grupo de Trabajo del Programa Integrado de Investigación en Tuberculosis en España Tags: Arch Bronconeumol Source Type: research

Blockade of PDE4B limits lung vascular permeability and lung inflammation in LPS-induced acute lung injury.
Abstract Acute lung injury (ALI), acute respiratory distress syndrome (ARDS), is actually involved in an ongoing and uncontrolled inflammatory response in lung tissues. Although extensive studies suggested that PDE4B may be related to inflammation, the underlying cell biological mechanism of ALI remains unclear. To further investigate the mechanism how PDE4B take part in inflammatory response and the maintenance of vascular integrity, we established the experimental model of ALI in vitro and in vivo. In vitro, we found that Cilomilast, Diazepam and PDE4B knockout could potently inhibit the LPS-induced NF-κB activa...
Source: Biochemical and Biophysical Research communications - July 11, 2014 Category: Biochemistry Authors: Ma H, Shi J, Wang C, Guo L, Gong Y, Li J, Gong Y, Yun F, Zhao H, Li E Tags: Biochem Biophys Res Commun Source Type: research

Intraoperative apnea in children after buffered 5% povidone‐iodine site sterilization for stabismus surgery
ConclusionsApnea at the time of ocular preparation with buffered 5% povidone‐iodine solution is common. The precise mechanism of this response is unknown. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - July 10, 2014 Category: Anesthesiology Authors: John D. Emhardt, Kathryn M. Haider, David A. Plager, Dava L. Grundhoefer Tags: Original Article Source Type: research

A compartment model of alveolar–capillary oxygen diffusion with ventilation–perfusion gradient and dynamics of air transport through the respiratory tract
(Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 10, 2014 Category: Bioinformatics Authors: Jacek Jaworski, Grzegorz Redlarski Source Type: research

Interim CDC Guidance for Polio Vaccination for Travel to and from Countries Affected by Wild Poliovirus.
Abstract In the prevaccine era, infection with wild poliovirus (WPV) was common worldwide, with seasonal peaks and epidemics in the summer and fall in temperate areas. The incidence of poliomyelitis in the United States declined rapidly after the licensure of inactivated polio vaccine (IPV) in 1955 and live oral polio vaccine (OPV) in the 1960s. The last cases of indigenously acquired WPV in the United States occurred in 1979, the last WPV case in a U.S. resident traveling abroad occurred in 1986, and the last WPV imported case was in 1993. Since 2000, the United States has exclusively used IPV, resulting in preven...
Source: MMWR Morb Mortal Wkl... - July 10, 2014 Category: Epidemiology Authors: Wallace GS, Seward JF, Pallansch MA, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, CDC Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Quartz and Respirable Dust in the Dutch Construction Industry: A Baseline Exposure Assessment as Part of a Multidimensional Intervention Approach
In conclusion, the detailed information on determinants of exposure, use of control measures, and constraints to use these control measures can be used for the determination and systematic prioritization of intervention measures used to design and implement our intervention strategy. This study underlines the need for multidisciplinary workplace exposure control strategies although larger study populations are necessary to determine a possible causal association between organizational and psychosocial factors and psychosocial factors and control measures. (Source: Annals of Occupational Hygiene)
Source: Annals of Occupational Hygiene - July 10, 2014 Category: Occupational Health Authors: van Deurssen, E., Pronk, A., Spaan, S., Goede, H., Tielemans, E., Heederik, D., Meijster, T. Tags: Original Article Source Type: research

Reconstruction of Historical Exposures at a Welsh Nickel Refinery (1953-2000)
This study uses nickel measurements from the 1970s to the present, documentation of process changes, and dust measurements taken around the1950s to construct an exposure matrix for the recent cohort. It provides evidence of at least 30-fold decreases in levels of nickel exposure from the 1950s to the present, with estimated inhalable nickel concentrations in the 1950s in excess of 5mg Ni m–3. (Source: Annals of Occupational Hygiene)
Source: Annals of Occupational Hygiene - July 10, 2014 Category: Occupational Health Authors: Sivulka, D. J., Seilkop, S. K., Lascelles, K., Conard, B. R., Jones, S. F., Collinson, E. C. Tags: Original Article Source Type: research

Respiratory Source Control Using Surgical Masks With Nanofiber Media
Conclusions: Substituting nanofiber for conventional filter media significantly reduced face mask airflow resistance directing more airflow through the face mask resulting in enhanced filtration. Respiratory source control efficacy similar to that achieved through the use of an N95 respirator worn by the source and decreased airflow resistance using nanofiber masks may improve compliance and reduce receiver exposure. (Source: Annals of Occupational Hygiene)
Source: Annals of Occupational Hygiene - July 10, 2014 Category: Occupational Health Authors: Skaria, S. D., Smaldone, G. C. Tags: Original Article Source Type: research

Respiratory symptoms and lung function abnormalities related to work at a flavouring manufacturing facility
Conclusions Symptoms and lung function findings were consistent with undiagnosed or subclinical obliterative bronchiolitis and associated with workplace exposures. Further efforts to lower exposures to flavouring chemicals, including diacetyl substitutes, are warranted. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - July 10, 2014 Category: Occupational Health Authors: Cummings, K. J., Boylstein, R. J., Stanton, M. L., Piacitelli, C. A., Edwards, N. T., LeBouf, R. F., Kreiss, K. Tags: Editor's choice, Other exposures Workplace Source Type: research

Lactate dehydrogenase as a biomarker for silica exposure-induced toxicity in agate workers
Conclusions This study proposes that total LDH activity and the LDH ratio (plasma/cells), along with occupational exposure history, are markers for silica exposure-induced toxicity in agate workers. (Source: Occupational and Environmental Medicine)
Source: Occupational and Environmental Medicine - July 10, 2014 Category: Occupational Health Authors: Aggarwal, B. D. Tags: Respiratory, Other exposures Exposure assessment Source Type: research

Biofilm‐specific extracellular matrix proteins of nontypeable Haemophilus influenzae
Abstract Nontypeable Haemophilus influenzae (NTHi), a human respiratory tract pathogen, can form colony biofilms in vitro. Bacterial cells and the amorphous extracellular matrix (ECM) constituting the biofilm can be separated using sonication. The ECM from 24‐ and 96‐h NTHi biofilms contained polysaccharides and proteinaceous components as detected by nuclear magnetic resonance (NMR) and Fourier transform infrared spectroscopy (FTIR) spectroscopy. More conventional chemical assays on the biofilm ECM confirmed the presence of these components and also DNA. Proteomics revealed eighteen proteins present in biofilm ECM tha...
Source: FEMS Immunology and Medical Microbiology - July 10, 2014 Category: Microbiology Authors: Siva Wu, Marc M. Baum, James Kerwin, Debbie Guerrero, Simon Webster, Christoph Schaudinn, David VanderVelde, Paul Webster Tags: Research Article Source Type: research

Sickle Cell Disease in children: chronic complications and search of predictive factors for adverse outcomes
ConclusionsLeucocytosis and dactylitis in the first year of life can be predictors of SCD severity while the presence of α‐thalassemia can be protective. The determination of early predictors of chronic complications of SCD may improve the comprehensive care of these patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - July 10, 2014 Category: Hematology Authors: Inês Vaz Silva, Ana Filipa Reis, Maria João Palaré, Anabela Ferrão, Teresa Rodrigues, Anabela Morais Tags: Original Article Source Type: research

Can epidemic detection systems at the hospital level complement regional surveillance networks: Case study with the influenza epidemic?
Conclusions: The implementation of an automatic surveillance system to detect patients with influenza or respiratory syndrome from computerized ED records could allow outbreak alerts at the intra-hospital level before the publication of regional data and could accelerate the implementation of preventive transmission-based precautions in hospital settings. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 10, 2014 Category: Infectious Diseases Authors: Solweig Gerbier-ColombanVéronique Potinet-PagliaroliMarie-Hélène Metzger Source Type: research

NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study
Conclusions: Cigarette smoking appears to increase the risk of elevated levels of serum ALT or serum GGT in ND2-237Met genotypic men, but to decrease the risk of elevated levels of serum ALT in ND2-237Leu genotypic men. (Source: BioMed Central)
Source: BioMed Central - July 10, 2014 Category: Journals (General) Authors: Akatsuki KokazeMasao YoshidaMamoru IshikawaNaomi MatsunagaKanae KaritaTadahiro OhtsuHirotaka OchiaiTakako ShirasawaHinako NanriYuta BabaHiromi HoshinoYutaka Takashima Source Type: research

Sleep pathology characterization in sickle cell disease: Case–control study
ConclusionComparing children with and without SCD, sleep architecture was similar in both groups and minimum SpO2 was significantly lower in SCD children although both groups had a similar AHI. This is an important issue in these children, so it is essential to have a sleep evaluation in order to prevent complications and co‐morbidities. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 10, 2014 Category: Respiratory Medicine Authors: Maria Inês Mascarenhas, Helena Cristina Loureiro, Teresa Ferreira, Alexandra Dias Tags: Original Article: Sleep & Breathing Source Type: research

Lung function over the first 3 years of life in children with congenital diaphragmatic hernia
ConclusionsLung functions of survivors of CDH remain abnormal throughout the first 3 years of life. The degree of pulmonary function impairment correlated both with markers of the initial degree of pulmonary hypoplasia and the duration of mechanical ventilation. Understanding the relationship between the phenotypic presentation of CDH and the potential for subsequent lung growth could help refine both pre‐ and postnatal therapies to optimize lung growth in CDH infants. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - July 10, 2014 Category: Respiratory Medicine Authors: Howard B. Panitch, Daniel J. Weiner, Rui Feng, Myrza R. Perez, Fiona Healy, Joseph M. McDonough, Natalie Rintoul, Holly L. Hedrick Tags: Original Article: Neonatal Lung Disease Source Type: research

Functional mapping of community‐acquired respiratory distress syndrome (CARDS) toxin of Mycoplasma pneumoniae defines regions with ADP‐ribosyltransferase, vacuolating and receptor‐binding activities
Summary Community‐acquired respiratory distress syndrome (CARDS) toxin from Mycoplasma pneumoniae is a 591‐amino‐acid virulence factor with ADP‐ribosyltransferase (ADPRT) and vacuolating activities. It is expressed at low levels during in vitro growth and at high levels during colonization of the lung. Exposure of experimental animals to purified recombinant CARDS toxin alone is sufficient to recapitulate the cytopathology and inflammatory responses associated with M. pneumoniae infection in humans and animals. Here, by molecular modelling, serial truncations and site‐directed mutagenesis, we show that the N‐te...
Source: Molecular Microbiology - July 10, 2014 Category: Microbiology Authors: Thirumalai R. Kannan, Manickam Krishnan, Kumaraguruparan Ramasamy, Argentina Becker, Olga N. Pakhomova, P. John Hart, Joel B. Baseman Tags: Research Article Source Type: research

Recent outbreak of scrub typhus in North Western part of India
Conclusion: Scrub typhus has emerged as an important cause of febrile illness in Jaipur. Empirical treatment with doxycycline is justified in endemic areas. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 10, 2014 Category: Microbiology Authors: Parul SinhaSweta GuptaRomika DawraPuneet Rijhawan Source Type: research

Diagnosis of ventilator-associated pneumonia: Comparison between ante-mortem and post-mortem cultures in trauma patients
Conclusions: Culture results of a properly collected tracheal aspirate should be taken into consideration along with Centre for Disease Control and Prevention (CDC's) diagnostic criteria to maximise the diagnosis of VAP. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - July 10, 2014 Category: Microbiology Authors: S LalwaniP MathurV TakS JananiSI KumarR BaglaMC Misra Source Type: research

Comparison of acoustic and impedance methods with mask capnometry to assess respiration rate in obese patients recovering from general anaesthesia
In this study, respiration rate was simultaneously recorded every second for up to 60 min using a computer in 30 adult obese patients (body mass index ≥ 35 kg.m−2), by three methods: acoustic; thoracic impedance; and capnometry via a facemask (Capnomask®, reference method). Of the 99 771 data triplets collected, only 85 520 (86%) were included; 12 021 (84%) were not studied due to failure of capnometry and 2240 (16%) due to failure of the acoustic method. Compared with capnometry, bias was similar using both the acoustic method and impedance (−0.3 bpm vs −0.6 bpm, respectively, p = 0.09), but limits of ...
Source: Anaesthesia - July 10, 2014 Category: Anesthesiology Authors: D. Frasca, L. Geraud, J.‐M. Charriere, B. Debaene, O. Mimoz Tags: Original Article Source Type: research

Characterization of a Respiratory Complex from P. furiosus [Membrane Biology]
The archaeon Pyrococcus furiosus grows optimally at 100 °C by converting carbohydrates to acetate, CO2, and H2, obtaining energy from a respiratory membrane-bound hydrogenase (MBH). This conserves energy by coupling H2 production to oxidation of reduced ferredoxin with generation of a sodium ion gradient. MBH is encoded by a 14-gene operon with both hydrogenase and Na+/H+ antiporter modules. Herein a His-tagged MBH was expressed in P. furiosus and the detergent-solubilized complex purified under anaerobic conditions by affinity chromatography. Purified MBH contains all 14 subunits by electrophoretic analysis (13 subunits ...
Source: Journal of Biological Chemistry - July 10, 2014 Category: Chemistry Authors: McTernan, P. M., Chandrayan, S. K., Wu, C.-H., Vaccaro, B. J., Lancaster, W. A., Yang, Q., Fu, D., Hura, G. L., Tainer, J. A., Adams, M. W. W. Tags: Enzymology Source Type: research

Inhibitory Effect of Hydrogen Sulfide on Ozone-induced Airway Inflammation, Oxidative Stress and Bronchial Hyperresponsiveness.
Abstract Exposure to ozone (O3) has been associated with airway inflammation, oxidative stress and bronchial hyperresponsiveness (BHR). The goal of this study was to examine whether these adverse effects of ozone could be prevented or reversed by hydrogen sulfide (H2S) as a reducing agent. The H2S donor sodium hydrogen sulfide (NaHS) (2 mg/kg) or vehicle (PBS) was intraperitoneally injected into mice 1 hour before and after 3-hour ozone (2.5 ppm) or air exposure, and the mice were studied 24 hours later. Preventive and therapeutic treatment with NaHS reduced the ozone-induced increases in the total cells, including...
Source: American Journal of Respiratory Cell and Molecular Biology - July 10, 2014 Category: Molecular Biology Authors: Zhang P, Li F, Wiegman CH, Zhang M, Hong Y, Gong J, Chang Y, Zhang JJ, Adcock I, Chung KF, Zhou X Tags: Am J Respir Cell Mol Biol Source Type: research

[Complications in pediatric anesthesia.]
Abstract As in adult anesthesia, morbidity and mortality could be significantly reduced in pediatric anesthesia in recent decades. This fact cannot conceal the fact that the incidence of anesthetic complications in children is still much more common than in adults and sometimes with a severe outcome. Newborns and infants in particular but also children with emergency interventions and severe comorbidities are at increased risk of potential complications. Typical complications in pediatric anesthesia are respiratory problems, medication errors, difficulties with the intravenous puncture and pulmonal aspiration. In t...
Source: Der Anaesthesist - July 10, 2014 Category: Anesthesiology Authors: Becke K Tags: Anaesthesist Source Type: research

The Anticoagulation of Calf Thrombosis (ACT) project: results from the randomized controlled external pilot trial.
ConclusionsWe have established the feasibility of definitive study regarding the value of therapeutic anticoagulation in IDDVT and provide an approximate point estimate for serious complications with a contemporary conservative strategy. Clinical Trial Registrationwww.controlled-trials.com/ISRCTN75175695. Background: There is currently little evidence defining the clinical importance of detecting and treating isolated distal deep vein thrombosis (IDDVT). International guidelines vary regarding diagnostic and therapeutic advice. The potential benefits of anticoagulation are unquantified. We sought to evaluate the feasib...
Source: Chest - July 10, 2014 Category: Respiratory Medicine Authors: Horner D, Hogg K, Body R, Nash MJ, Baglin T, Mackway-Jones K Tags: Chest Source Type: research

Novel use of pleural ultrasound can identify malignant entrapped lung prior to effusion drainage.
ConclusionsThis novel ultrasound technique can identify entrapped lung prior to effusion drainage, which could allow appropriate choice of definitive management (pleurodesis versus indwelling catheter), reducing the number of interventions required to treat malignant pleural effusion. Rationale: The presence of entrapped lung changes the appropriate management of malignant pleural effusion from pleurodesis to insertion of an indwelling pleural catheter. No methods currently exist to identify entrapped lung prior to effusion drainage. Objectives: To develop a method to identify entrapped lung using tissue movement a...
Source: Chest - July 10, 2014 Category: Respiratory Medicine Authors: Salamonsen MR, Lo AK, Ng AC, Bashirzadeh F, Wang WY, Fielding DI Tags: Chest Source Type: research

Tree and forest effects on air quality and human health in the United States.
Abstract Trees remove air pollution by the interception of particulate matter on plant surfaces and the absorption of gaseous pollutants through the leaf stomata. However, the magnitude and value of the effects of trees and forests on air quality and human health across the United States remains unknown. Computer simulations with local environmental data reveal that trees and forests in the conterminous United States removed 17.4 million tonnes (t) of air pollution in 2010 (range: 9.0-23.2 million t), with human health effects valued at 6.8 billion U.S. dollars (range: $1.5-13.0 billion). This pollution removal equ...
Source: Environmental Pollution - July 10, 2014 Category: Environmental Health Authors: Nowak DJ, Hirabayashi S, Allison Bodine, Greenfield E Tags: Environ Pollut Source Type: research

Distal-proximal crosstalk in the heme binding pocket of the NO sensor DNR.
Abstract In the opportunistic pathogen Pseudomonas aeruginosa the denitrification process is triggered by nitric oxide (NO) and plays a crucial role for the survival in chronic infection sites as a microaerobic-anaerobic biofilm. This respiratory pathway is transcriptionally induced by DNR, an heme-based gas sensor which positively responds to NO. Molecular details of the NO sensing mechanism employed by DNR are now emerging: we recently reported an in vitro study which dissected, for the first time, the heme-iron environment and identified one of the heme axial ligand (i.e. His187), found to be crucial to respond ...
Source: Biometals - July 10, 2014 Category: Biochemistry Authors: Cutruzzolà F, Arcovito A, Giardina G, Della Longa S, D'Angelo P, Rinaldo S Tags: Biometals Source Type: research

Pseudoxanthobacter liyangensis sp. nov., isolated from a DDT-contaminated soil.
Abstract An aerobic, Gram-stain negative, pale, rod-shaped, nitrogen-fixing bacterial strain DDT-3T was isolated from a dichlorodiphenyltrichloroethane-contaminated soil in Liyang, China. Strain DDT-3T grew at temperatures ranging from 20-40°C (optimum at 30-37°C) and pH ranges from 5.0-10.0 (optimum at pH 7.0-8.0). The G+C content of the total DNA was 70.1 mol%. The 16S rRNA gene sequence of strain DDT-3T showed the highest similarity to that of Pseudoxanthobacter soli CC4T (99.6%), followed by Kaistia dalseonensis B6-8T (93.3%), Kaistia soli 5YN9-8T (93.0%) and Amorphous orientalis YIM D10 T (93.0%). Strain DDT...
Source: International Journal of Systematic and Evolutionary Microbiology - July 10, 2014 Category: Microbiology Authors: Liu XM, Chen K, Meng C, Zhang L, Zhu JC, Huang X, Li SP, Jiang JD Tags: Int J Syst Evol Microbiol Source Type: research

Flavobacterium arsenatis sp. nov., a novel anti-arsenic bacterium from the high-arsenic sediment in Jianghan Plain, China.
Abstract A novel bacterial strain Z(T) was isolated from the high-arsenic sediment in Jianghan Plain, China. The strain was Gram-staining-negative, rod-shaped, and formed yellow colonies. This bacterium is capable of resisting to arsenate and arsenite with the MICs of 40 mM and 20 mM, respectively. The strain also possesses catalase, and doesn't produce oxidase. The nucleotide sequence of the 16S rRNA gene of the isolate showed the highest similarity (96.9%) to that of the type strain of Flavobacterium soli. According to the 16S rRNA gene sequence analysis and the phenotypic properties of the strain Z(T), it was as...
Source: International Journal of Systematic and Evolutionary Microbiology - July 10, 2014 Category: Microbiology Authors: Ao L, Zeng XC, Nie Y, Mu Y, Zhou L, Luo X Tags: Int J Syst Evol Microbiol Source Type: research

Production of Acylated Homoserine Lactone by a novel marine strain of Proteus vulgaris and inhibition of its swarming by phytochemicals.
Abstract A marine strain of Proteus vulgaris, capable of activating multiple acylated homoserine lactone (AHL) -based reporter cultures, was isolated. The cognate signal molecule was characterized as octanoyl homoserine lactone (OHL)and its production was observed to be growth dependent, with maximum production( 5.675µg/L) at the 24th hour of its growth. The strain exhibited swarming but its motility was not affected upon addition of pure OHL or culture supernatant. Phytochemicals such as quercitin and berberine chloride inhibited OHL production as well as reduced swarming. FliA, the predominantly upregulated prot...
Source: Microbiology - July 10, 2014 Category: Microbiology Authors: Biswa P, Doble M Tags: Microbiology Source Type: research

The 'Malawi device': a durable, reusable, low cost device from own materials for emergency ventilation during percutaneous tracheostomy.
We describe a method by which the airway and ventilation can be maintained if accidental tracheal extubation occurs before completion of a percutaneous tracheostomy. The 'Malawi Device', a cheap and simple modification of readily available equipment, enables a single operator to maintain the airway and ventilate the patient when the above scenario occurs. PMID: 25011380 [PubMed - as supplied by publisher] (Source: Tropical Doctor)
Source: Tropical Doctor - July 10, 2014 Category: Tropical Medicine Authors: Pollach G, Namboya F, Jung K Tags: Trop Doct Source Type: research