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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

1182pd * prognostic factors in resected ais, mia and lepidic predominant lung adenocarcinoma
Conclusions: The overall survival and freedom from recurrence rates were good in lepidic predominant adenocarcinoma. TNM stage (II-III vs. I) was a significant predictive factor of freedom from recurrence in these patients.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Hung, J., Chou, T., Hsu, W., Wu, Y. Tags: NSCLC, early stage Source Type: research

1239p * feasibility of home delivery (hd) of maintenance pemetrexed (pem) therapy for advanced nonsquamous non small cell lung cancer (adv nsqnsclc)
Conclusions: HD of maintenance PEM therapy in adv nsqNSCLC was feasible, safe, and preferred by patients, while maintaining HRQoL. Physicians were satisfied with distant patient management. Community-based clinical research requires specific consideration and resource allocation.Disclosure: M.C. Nicolson: The author has a personal specific interest in terms of advisory board work and also paid lectures for Lilly; also non-personal specific in terms of research support and meeting attendance support; C.M. Visseren-Grul: Lilly Employee The author declares no conflict of interest; M. Lorenzo: Lilly Employee The author declare...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Lal, R., Summers, Y., Shah, R., Crosse, B., Thompson, J., Nicolson, M. C., Potter, V., Visseren-Grul, C. M., Vikstrom, A., Lorenzo, M., D'Yachkova, Y., Bourayou, N., Hillerdal, G. Tags: NSCLC, metastatic Source Type: research

1327p * a phase i open-label study to evaluate the safety and tolerability of medi4736, an anti-programmed cell death-ligand 1(pd-l1) antibody, in combination with tremelimumab in patients with advanced non-small cell lung cancer (nsclc)
Conclusions: The current safety profile and early anti-tumor activity of M + T supports continued clinical assessment.Disclosure: S.J. Antonia: Honoraria from BMS and MedImmune/Astra Zeneca for work related to designing, implementing, and analyzing various clinical trials. MedImmune considers the research funding received for the conduct of a MedImmune-sponsored study as conflict of interest; S. Goldberg: I have received research funding from MedImmune and AstraZeneca. MedImmune considers the research funding received for the conduct of a MedImmune-sponsored study as conflict of interest; A. Balmanoukian: Research/clinical...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Antonia, S. J., Goldberg, S., Balmanoukian, A., Narwal, R., Robbins, P. B., D'Angelo, G., Blake-Haskins, A., Karakunnel, J. J., Rizvi, N. Tags: NSCLC, metastatic Source Type: research

1352p * active palliation and new treatment strategies for malignant ascites using km-cart
Conclusion: The KM-CART system was considered easy to use and very safe, and the recovery of large volumes of autologous proteins was thought to have improved general status, nutrition, and immune status, as well as subjective symptoms. In addition, the recovered cancer cells were able to be used for drug sensitivity tests and immune cell therapy, indicating the potential for new treatment strategies for malignant ascites in the future.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Matsusaki, K., Tsujitani, S., Yoshizawa, A., Ohta, K. Tags: palliative care Source Type: research

1485pd * outpatient management of cancer-related pulmonary embolism: a propensity score-matched analysis of 803 patients from the epiphany study
Conclusions: Outpatient management of low-risk cancer-related PE appears to be safe and effective. A randomized trial is needed to confirm these data and assess outcomes in specific subgroups.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Carmona-Bayonas, A., Biosca, M., Puig, C. F., Faez, L., Solis Hernandez, M. D. P., Jimenez Fonseca, P., Antonio Rebollo, M., De La Haba, I., Castanon Alvarez, E., Beato, C., Ramchandani, A., Vicente Conesa, M. A., Madridano, O., Otero, R. Tags: supportive care Source Type: research

1511p * sompas: a prospective, non-interventional study (nis) of the management of symptomatic chemotherapy (ct)-induced anemia (cia) in patients (pts) with colorectal (crc), breast (bc) or lung cancer (lc) in austria (at) and switzerland (ch)
Conclusions: ESAs were used as per EORTC guidelines in 71% of pts, 51% of pts were initiated at Hb >10g/dL. Pts achieved a significant increase in Hb during ESA treatment; 90% had a Hb >10 g/dL. A large proportion of pts avoided RBCTs while treated with an ESA.Disclosure: G. Delmore: declares to be a member of the Amgen advisory board; C. Jaeger, C. Bast and I. Pezzani: declares to be an Amgen employee and to hold Amgen stock; M. Schmid: declares to be a member of the Amgen advisory board. All other authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Eisterer, W., Trojan, A., Galid, A., Haslbauer, F., Delmore, G., Kolb, R., Jaeger, C., Bast, C., Pezzani, I., Schmid, M. Tags: supportive care Source Type: research

1555TiP * ACCERT: AUCKLAND'S CANCER CACHEXIA EVALUATING RESISTANCE TRAINING STUDY
This study aims to identify a novel multi-targeted treatment regimen that will alleviate and/or stabilise CC weight loss.Methods: This is a randomised, open-label study to investigate whether 2 sessions each week of PRT followed by essential amino acids (EAA's) high in leucine, when administered in addition to Eicosapentaenoic Acid (EPA) and a Cox-2 inhibitor is acceptable to NSCLC cachectic patients for a period of 20 weeks (primary endpoint). Secondary endpoints include Lean Body Mass, MRI thigh skeletal muscle values, QoL and Fatigue questionnaires, serum pro-inflammatory cytokine profiles, and hand and leg strength. Sa...
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Rogers, E. S., Sasidharan, R., Sequeira, G. M., Wood, M. R., Bird, S. P., Arroll, B., Stewart, J., Keogh, J. W. L., Macleod, R. D. Tags: supportive care Source Type: research

1589p * comparison of the cardiotoxic effect of doxorubicin and liposome-encapsulation of doxorubicin under experimental condition
Conclusions: The liposomal-encapsulated doxorubicin-citrat (MYO) proved to be less cardiotoxic as compared with DOX, resulting in better LV and RV systolic and LV diastolic function in association with higher expression levels of oxidative, cell cycle and energy genes in an experimental model of cardiotoxic cytostatic therapy.Disclosure: All authors have declared no conflicts of interest. (Source: Annals of Oncology)
Source: Annals of Oncology - September 24, 2014 Category: Cancer & Oncology Authors: Gyongyosi, M., Maurer, G., Bergler-Klein, J. Tags: translational research Source Type: research

Flavobacterium gyeonganense sp. nov., isolated from freshwater, and emended descriptions of Flavobacterium chungangense , Flavobacterium aquidurense , Flavobacterium tructae and Flavobacterium granuli.
Abstract A Gram-staining negative, aerobic and rod shaped bacterial strain, designated as HME7524T, was isolated from freshwater of Gyeong-an stream in Korea. A phylogenetic tree based on 16S rRNA gene sequences showed that strain HME7524T formed a distinct lineage within the genus Flavobacterium and exhibited high sequence similarity with Flavobacterium chungangense CJ7T (96.9%), F. aquidurense WB-1.1.56 T (96.9%), F. tructae 435-08T (96.9%) F. granuli Kw05T (96.9%). The major fatty acids of strain HME7524T were iso-C15:0 (26.5%) and summed feature 3 (comprising C16:1 ω6c and/or C16:1 ω7c; 17.4%). The major pola...
Source: International Journal of Systematic and Evolutionary Microbiology - September 24, 2014 Category: Microbiology Authors: Kim H, Kang H, Joung Y, Joh K Tags: Int J Syst Evol Microbiol Source Type: research

Microbacterium petrolearium sp. nov., isolated from oil-contaminated water sample from Dagang oilfield in China.
Abstract A Gram-positive, rod-shaped aerobic bacterium, designated strain LAM0410(T),was isolated from oil contaminated water sample from Dagang Oilfield, China. The temperature and pH ranges for growth were 4 °C to 50 °C and 4.4 to 12.0, respectively. The strain did not need NaCl for growth but could tolerate up to 12% concentration. Cell wall hydrolysates from the isolate showed that the diamino acids was ornithine. The cell wall sugars contains ribose and galactose. The glycan moiety of the cell wall contained N-glycolyl residues. The major respiratory quinones were MK-10, MK-11 and MK-12. The major polar li...
Source: International Journal of Systematic and Evolutionary Microbiology - September 24, 2014 Category: Microbiology Authors: Wang H, Xiang T, Wang Y, Song J, Zhai Y, Chen X, Li Y, Zhao B, Zhao B, Ruan Z Tags: Int J Syst Evol Microbiol Source Type: research

Reprint of: Coronavirus reverse genetic systems: Infectious clones and replicons.
In this report, we briefly review and discuss the different reverse genetic systems developed for CoVs, paying special attention to the severe acute respiratory syndrome CoV (SARS-CoV). PMID: 25261606 [PubMed - as supplied by publisher] (Source: Virus Research)
Source: Virus Research - September 24, 2014 Category: Virology Authors: Almazán F, Sola I, Zuñiga S, Marquez-Jurado S, Morales L, Becares M, Enjuanes L Tags: Virus Res Source Type: research

Perturbations in Intracellular Ca2+ Handling in Skeletal Muscle in the G93A*SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.
Abstract Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease characterized by skeletal muscle atrophy and weakness, ultimately leading to respiratory failure. The purpose of this study was to assess changes in skeletal muscle excitation-contraction (e-c) coupling and intracellular Ca(2+) handling during disease progression in the G93A*SOD1 mouse model of ALS. To assess e-c coupling, single muscle fibres were electrically stimulated (10-150Hz) and intracellular free Ca(2+) concentration assessed using Fura-2. There were no differences in peak Fura-2 ratio at any stimulation frequency at 70...
Source: Am J Physiol Cell Ph... - September 24, 2014 Category: Cytology Authors: Chin ER, Chen D, Bobyk K, Mazala DA Tags: Am J Physiol Cell Physiol Source Type: research

Functional Mitochondrial Analysis in Acute Brain Sections from Adult Rats Reveals Mitochondrial Dysfunction in a Rat Model of Migraine.
Abstract Mitochondrial dysfunction has been implicated in many neurological disorders that only develop or are much more severe in adults, yet no methodology exists which allows for medium-throughput functional mitochondrial analysis of brain sections from adult animals. We developed a technique for quantifying mitochondrial respiration in acutely isolated adult rat brain sections with the Seahorse XF Analyzer. Evaluating a range of conditions made quantifying mitochondrial function from acutely derived adult brain sections from the cortex, cerebellum, and trigeminal nucleus caudalis possible. Optimization of this ...
Source: Am J Physiol Cell Ph... - September 24, 2014 Category: Cytology Authors: Fried NT, Moffat C, Seifert EL, Oshinsky ML Tags: Am J Physiol Cell Physiol Source Type: research

Exacerbation of asthma and airway infection: is the virus the villain?
CONCLUSIONS: respiratory viruses are present in the majority of asthmatic children during episodes of exacerbation. The involved physiopathological mechanisms are yet to be fully established, and the synergism between allergic inflammation and viral infection appears to determine uncontrolled disease. The role of other triggering and protective agents is yet to be clearly determined. PMID: 25261603 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - September 24, 2014 Category: Pediatrics Authors: Costa LD, Costa PS, Camargos PA Tags: J Pediatr (Rio J) Source Type: research

Guidelines for diagnosis and treatment of Hunter Syndrome for clinicians in Latin America
This review aims to provide clinicians in Latin America with the most current information on the clinical aspects, diagnosis, and management of Hunter syndrome, a serious and progressive disease for which specific treatment is available. Hunter syndrome is a genetic disorder where iduronate-2-sulfatase (I2S), an enzyme that degrades glycosaminoglycans, is absent or deficient. Clinical manifestations vary widely in severity and involve multiple organs and tissues. An attenuated and a severe phenotype are recognized depending on the degree of cognitive impairment. Early diagnosis is vital for disease management. Clinical sig...
Source: Genetics and Molecular Biology - September 23, 2014 Category: Genetics & Stem Cells Source Type: research

Lung function abnormalities in HIV‐infected adults and children
Abstract Despite the advent of antiretroviral therapy (ART), the human immunodeficiency virus (HIV) epidemic remains a global health crisis with a high burden of respiratory disease among infected persons. While the early complications of the epidemic were dominated by opportunistic infections, improved survival has led to the emergence of non‐infectious conditions that are associated with chronic respiratory symptoms and pulmonary disability. Obstructive ventilatory defects and reduced diffusing capacity are common findings in adults, and the association between HIV and chronic obstructive pulmonary disease is increasin...
Source: Respirology - September 23, 2014 Category: Respiratory Medicine Authors: Gregory L. Calligaro, Diane M. Gray Tags: Invited review series: Respiratory Disease: Using Lung Function Measurements to Greater Advantage Source Type: research

Biosynthesis of antifungal and antibacterial polyketides by Burkholderia gladioli in coculture with Rhizopus microsporus
Summary Fungi–bacteria interactions can impact the course of fungal infection and biotechnological use. The mucoralean fungus Rhizopus microsporus, traditionally used in food fermentations (tempe and sufu), is frequently accompanied by Burkholderia gladioli pv. cocovenenans. When producing tempe bongkrek, the bacterial contamination can lead to lethal food‐related intoxications caused by the respiratory toxin bongkrekic acid. To unveil the metabolic potential of the fungus‐associated bacterium, we sequenced its genome, assigned secondary metabolite biosynthesis gene clusters and monitored the metabolic profile under ...
Source: Mycoses - September 23, 2014 Category: Research Authors: Claudia Ross, Viktoria Opel, Kirstin Scherlach, Christian Hertweck Tags: Supplement Article Source Type: research

Impact of the Anesthetic Conserving Device on Respiratory Parameters and Work of Breathing in Critically Ill Patients under Light Sedation with Sevoflurane
Conclusions: ACD increases work of breathing and worsens ventilatory parameters. Sevoflurane use via the ACD (for a light-sedation target) normalizes respiratory parameters. In this patient’s population, light-sedation with sevoflurane and the ACD may be possible during the weaning process. (Source: Anesthesiology)
Source: Anesthesiology - September 23, 2014 Category: Anesthesiology Tags: Critical Care Medicine: Clinical Science Source Type: research

A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea: Could Preoperative Diagnosis and Treatment Prevent Complications?
Conclusions: Diagnosis of OSA and prescription of continuous positive airway pressure therapy were associated with a reduction in postoperative cardiovascular complications. Despite limitations in the data, these results could be used to justify and inform large efficacy trials of perioperative continuous positive airway pressure therapy in OSA patients. (Source: Anesthesiology)
Source: Anesthesiology - September 23, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Clinical Science Source Type: research

Peri‐operative massive pulmonary embolism management: is veno‐arterial ECMO a therapeutic option?
Pulmonary embolism remains an important clinical problem with a high mortality rate. The potential for sudden and fatal hemodynamic deterioration highlights the need for a prompt diagnosis and appropriate intervention. The purpose of the present case report is to describe a successful peri‐operative veno‐arterial extra corporeal membrane oxygenation (VA‐ECMO) implantation for assumed massive pulmonary embolism associated with high hemodynamic instability and severe hypoxemia. A 52‐year‐old female victim of a motorcycle accident had been operated on for unstable fractures that required optimal repair. Despite subc...
Source: Acta Anaesthesiologica Scandinavica - September 23, 2014 Category: Anesthesiology Authors: G. PAVLOVIC, C. BANFI, D. TASSAUX, R. E. PETER, M. J. LICKER, K. BENDJELID, R. GIRAUD Tags: Case Report Source Type: research

The collision auto repair safety study (CARSS): A health and safety intervention
ConclusionsSmall businesses' interventions should address the lack of personnel and administrative infrastructure. Tailored information regarding hazards and easy‐to‐use training and administrative programs overcome many barriers to improvement. Am. J. Ind. Med. © 2014 Wiley Periodicals, Inc. (Source: American Journal of Industrial Medicine)
Source: American Journal of Industrial Medicine - September 23, 2014 Category: Occupational Health Authors: David L. Parker, Anca Bejan, Lisa M. Brosseau, Maryellen Skan, Min Xi Tags: Research Article Source Type: research

Application of WHO's guideline for the selection of sentinel sites for hospital-based influenza surveillance in Indonesia
Conclusions: The multi-step process enabled sentinel site selection based on the WHO recommended attributes that emphasize right-sizing the surveillance system to ensure its stability and maximizing its geographic representativeness. This experience may guide other countries interested in adopting WHO's influenza surveillance standards for sentinel site selection. (Source: BMC Health Services Research)
Source: BMC Health Services Research - September 23, 2014 Category: Journals (General) Authors: Ni SusilariniMartahan SitorusCatharina PraptaningsihOndri SampurnoArie BratasenaEster MulyadiRoselinda RusliAhmad FandilAmalya MangiriHana ApsariEdy HariyantoGina Samaan Source Type: research

Effect of increasing respiratory rate on airway resistance and reactance in COPD patients
ConclusionsCharacteristic changes in IOS measurements, particularly expiratory reactance, induced by increased respiratory rates, were correlated with severity of dyspnoea in COPD patients during their daily lives. IOS and paced breathing may be useful for assessing breathlessness in COPD. (Source: Respirology)
Source: Respirology - September 23, 2014 Category: Respiratory Medicine Authors: Misa Nakagawa, Noboru Hattori, Yoshinori Haruta, Aya Sugiyama, Hiroshi Iwamoto, Nobuhisa Ishikawa, Kazunori Fujitaka, Hiroshi Murai, Junko Tanaka, Nobuoki Kohno Tags: Original Article Source Type: research

Role of C-reactive protein as a biomarker for prediction of the severity of pulmonary exacerbations in patients with cystic fibrosis
Conclusions: CRP level is not associated with the severity of pulmonary exacerbations, but it is associated with specific clinical characteristics. This simple scoring system (severity index) could prove very useful for evaluating the severity of exacerbations. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - September 23, 2014 Category: Respiratory Medicine Authors: Rosa Girón-MorenoJosé JusticiaSara YamamotoClaudia ValenzuelaCarolina CisnerosRosa Gómez-PúnterGilda Fernandes-VasconcelosJulio Ancochea Source Type: research

Antenatal corticosteroid therapy: Current strategies and identifying mediators and markers for response
Landmark early work has led to the nearly universal use of antenatal corticosteroids to accelerate fetal lung maturity with pregnancies complicated by impending preterm birth. Antenatal corticosteroids clearly reduce respiratory morbidity, death, and other adverse neonatal outcomes. Limited pregnant human pharmacokinetic data and some animal data give clinicians some information as to the behavior of the drug in the body. However, there is controversy about the type, amount, and frequency of steroid to use for this therapy. (Source: Seminars in Perinatology)
Source: Seminars in Perinatology - September 23, 2014 Category: Perinatology & Neonatology Authors: Nadia Falah, David M. Haas Source Type: research

Randomized Comparison of Recovery Time after Use of Remifentanil Alone Versus Midazolam and Meperidine for Colonoscopy Anesthesia
CONCLUSIONSRemifentanil for colonoscopy afforded faster recovery compared to midazolam‐meperidine combination. It also provided greater patient‐endoscopist communication and satisfaction with comparable patient analgesia and cardiorespiratory profile during colonoscopy. (Source: Digestive Endoscopy)
Source: Digestive Endoscopy - September 23, 2014 Category: Gastroenterology Authors: Mi Jin Hong, In‐Kyung Sung, Sang Pyo Lee, Bo‐Kyung Cheon, Hyun Kang, Tae‐Yop Kim Tags: Original Article Source Type: research

HIBCH deficiency in a patient with phenotypic characteristics of mitochondrial disorders
We report on a further patient, first child of healthy consanguineous parents, with severe developmental delay, seizures, hyperintensities of the basal ganglia on magnetic resonance imaging (MRI), progressive brain atrophy, optic nerve atrophy, repeatedly elevated blood lactate, and respiratory chain complexes I, I + III and cytochrome c oxidase deficiencies with borderline depletion of mitochondrial DNA in muscle tissue. Laboratory findings in blood and skeletal muscle were inconsistent and did not allow a definite diagnosis, but supported the hypothesis of mitochondrial dysfunction. Homozygosity mapping and whole‐e...
Source: American Journal of Medical Genetics Part A - September 23, 2014 Category: Genetics & Stem Cells Authors: Miriam S. Reuter, Jörn Oliver Sass, Thomas Leis, Julia Köhler, Johannes A. Mayr, René G. Feichtinger, Manfred Rauh, Ina Schanze, Luzy Bähr, Regina Trollmann, Steffen Uebe, Arif B. Ekici, André Reis Tags: Clinical Report Source Type: research

Deletion of both Rab-GTPase activating proteins TBC1D1 and TBC1D4 in mice eliminates insulin- and AICAR-stimulated glucose transport.
Abstract Previously, the Rab-GTPase activating proteins TBC1D1 and TBC1D4 (AS160) were shown to regulate GLUT4 translocation in response to activation of AKT and AMP-dependent kinase. However, knockout mice lacking either Tbc1d1 or Tbc1d4 displayed only partially impaired insulin-stimulated glucose uptake in fat and muscle tissue. The aim of this study was to determine the impact of the combined inactivation of Tbc1d1 and Tbc1d4 on glucose metabolism in double-deficient (D1/4KO) mice. D1/4KO mice displayed normal fasting glucose levels but had reduced tolerance to intraperitoneally administered glucose, insulin and...
Source: Diabetes - September 23, 2014 Category: Endocrinology Authors: Chadt A, Immisch A, de Wendt C, Springer C, Zhou Z, Stermann T, Holman GD, Loffing-Cueni D, Loffing J, Joost HG, Al-Hasani H Tags: Diabetes Source Type: research

Bronchoscopic treatment of complex persistent air leaks with endobronchial one-way valves
We reported a case series including 5 patients with persistent air-leaks refractory to standard treatment. All patients were unfit for surgery for the presence of co-morbidities and/or severe respiratory failure due to underlying lung diseases. They were successfully treated with bronchoscopic placement of endobronchial one-way valves. Air-leaks stopped in the first 24 h after the procedure in three patients and 3 and 5 days later, respectively, in the remaining two. No complications were observed and follow-up was uneventful in all patients but one died 25 days after the procedure for systemic sepsis due to peritonis. ...
Source: General Thoracic and Cardiovascular Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Source Type: research

A review of EPAP nasal device therapy for obstructive sleep apnea syndrome
Conclusions More studies are needed to assess the efficacy of and compliance with EPAP nasal devices, to define which patients will benefit from EPAP therapy, and to compare EPAP to other alternative OSA therapies. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 23, 2014 Category: Respiratory Medicine Source Type: research

Hacking into the granuloma: Could Antibody Antibiotic Conjugates be developed for TB?
Alternatives to small molecule or vaccine approaches to treating tuberculosis are rarely discussed. Attacking Mycobacterium tuberculosis in the granuloma represents a challenge. It is proposed that the conjugation of small molecules onto a monoclonal antibody that recognizes macrophage or lymphocytes cell surface receptors, might be a way to target the bacteria in the granuloma. This antibody drug conjugate approach is currently being used in 2 FDA approved targeted cancer therapies. The pros and cons of this proposal for further research are discussed. (Source: Tuberculosis)
Source: Tuberculosis - September 23, 2014 Category: Respiratory Medicine Authors: Sean Ekins Source Type: research

Chemotherapeutic efficacy of thioridazine as an adjunct drug in a murine model of latent tuberculosis
Thioridazine, a potent phenothiazine compound was evaluated for its chemotherapeutic efficacy against experiment model of tuberculosis. Thioridazine potentiated the activities of both isoniazid and rifampicin (>1 log CFU reduction) against the in vitro latent M.tuberculosis bacilli. Further, a murine model of latent tuberculosis was used and the standard 9-month isoniazid and 4-month rifampicin regimen along with thioridazine as an adjunct drug were evaluated. Thioridazine led to an accelerated clearance of bacilli with both the regimen, thereby leading to completion of therapy much earlier than the standard end-point. (Source: Tuberculosis)
Source: Tuberculosis - September 23, 2014 Category: Respiratory Medicine Authors: Amandeep Singh, Sadhna Sharma Tags: Drug Discovery and Resistance Source Type: research

Lung flute improves symptoms and health status in COPD with chronic bronchitis: A 26 week randomized controlled trial
Conclusions: The Lung Flute is a safe and effective treatment in COPD with chronic bronchitis, providing a wide array of benefits.ClinicalTrials.gov IdentifierNCT01186822 (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - September 23, 2014 Category: Internal Medicine Authors: Sanjay SethiJingjing YinPamela Anderson Source Type: research

Pathogenesis of Gallibacterium anatis in a natural infection model fulfils Koch's postulates: 2. Epididymitis and decreased semen quality are the predominant effects in specific pathogen free roosters.
In conclusion, the present study provides novel data on the impact of a G. anatis infection in roosters in a natural infection model elucidating on bacterial distribution, pathological lesions as well as influences on semen quality. PMID: 25246024 [PubMed - as supplied by publisher] (Source: Avian Pathology)
Source: Avian Pathology - September 23, 2014 Category: Pathology Authors: Paudea S, Liebhart D, Aurich C, Hess M, Hess C Tags: Avian Pathol Source Type: research

Prognostic Value of Plateau Pressure Below 30 cm H2O in Septic Patients With Acute Respiratory Failure.
CONCLUSIONS: Pplat within the first 24 h of ICU admission is predictive of outcome, with lower Pplat associated with lower mortality rates. There is no safety margin for Pplat. Limiting Pplat should be considered even at < 30 cm H2O in septic patients with acute respiratory failure. PMID: 25249650 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 23, 2014 Category: Respiratory Medicine Authors: Chan MC, Tseng JS, Chiu JT, Hsu KH, Shih SJ, Yi CY, Wu CL, Kou YR Tags: Respir Care Source Type: research

Relation of Exercise Capacity With Lung Volumes Before and After 6-Minute Walk in Subjects With COPD.
CONCLUSIONS: In subjects with stable COPD, lung volumes measured immediately after 6MWT are more closely related to exercise limitation than baseline lung volumes measured before 6MWT, except for FEV1. Therefore, pulmonary function testing immediately after exercise should be included in future studies on COPD for the assessment of exercise-induced ventilatory constraints to physical performance that cannot be adequately assessed from baseline pulmonary function testing at rest. PMID: 25249649 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 23, 2014 Category: Respiratory Medicine Authors: Wibmer T, Rüdiger S, Kropf-Sanchen C, Stoiber KM, Rottbauer W, Schumann C Tags: Respir Care Source Type: research

Azithromycin Attenuates Pulmonary Inflammation and Emphysema in Smoking-Induced COPD Model in Rats.
CONCLUSIONS: Azm attenuates pulmonary emphysema by partly reversing the decrease in the numbers of inflammatory cells (neutrophil and macrophage) and VEGF secretion and VEGFR2 protein expression in smoking-induced COPD in rats. PMID: 25249648 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 23, 2014 Category: Respiratory Medicine Authors: Wan YF, Huang ZH, Jing K, Li J, Wang Y, Xu CQ, Chen JH, Zhen YL Tags: Respir Care Source Type: research

Cough Characteristics and FVC Maneuver in Cystic Fibrosis.
CONCLUSIONS: The cough flow/volume maneuver reveals abnormalities in cough velocities and volume. A low secondary spike correlates with FEV1 severity level. The method may lead to earlier intervention to assist cough in CF. PMID: 25249647 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - September 23, 2014 Category: Respiratory Medicine Authors: Vilozni D, Lavie M, Ofek M, Sarouk I, Efrati O Tags: Respir Care Source Type: research

Salinithrix halophila gen. nov, sp. nov., a halophilic bacterium in the family Thermoactinomycetaceae.
Abstract A halophilic actinomycete, strain R4S8T was isolated from soil of Inche-Broun hypersaline wetland in the north of Iran. The isolate grew aerobically at temperatures of 30-50 °C (optimum temperature 40 °C), pH 6-10 (optimum pH 7.0) and NaCl concentrations 1-15 % w/v (optimum 3-5 %). It formed short and straight to moderately flexuous aerial mycelium without motile elements. The cell wall of strain R4S8T contained meso-diaminopimelic acid as diaminoacid without any diagnostic sugars. The polar lipid pattern consisted of phosphatidylglycerol, diphosphatidylglycerol, phosphatidylethanolamine, phosphatidyl se...
Source: International Journal of Systematic and Evolutionary Microbiology - September 23, 2014 Category: Microbiology Authors: Zarparvar P, Amoozegar MA, Moshtaghi Nikou M, Schumann P, Ventosa A Tags: Int J Syst Evol Microbiol Source Type: research

Altererythrobacter oceanensis sp. nov., isolated from the Western Pacific.
Abstract A Gram-stain negative, ovoid-rod shaped, strictly aerobic bacterium, strain Y2(T), was isolated from a deep-sea sediment of the Western Pacific. Phylogenetic and phenotypic properties of the organism indicated that it belongs to the genus Altererythrobacter. Strain Y2(T) shares highest 16S rRNA gene sequence similarity of 96.6 % with Erythrobacter jejuensis CNU001(T), followed by the type strains of recognized members of the genus Altererythrobacter (94.8-96.5 %). Strain Y2(T) forms a clade with E. jejuensis CNU001(T) in the cluster of species of the genus Altererythrobacter. Growth of strain Y2(T) was o...
Source: Antonie van Leeuwenhoek - September 23, 2014 Category: Microbiology Authors: Yang Y, Zhang G, Sun Z, Cheung MK, Huang C Tags: Antonie Van Leeuwenhoek Source Type: research

Venovenous extracorporeal membrane oxygenation in patients with atrial septal defects.
Abstract Two patients presented in profound respiratory distress unresponsive to maximal support and were placed on venovenous ECMO. Subsequently, both were found to have a patent foramen ovale and high pulmonary artery pressures, resulting in a right to left shunt. Both patients had a better than expected response to ECMO, likely related to their shunts allowing oxygenated blood to bypass the high pulmonary artery pressures and go directly to the left heart. Both patients were successfully weaned from ECMO and discharged to home in good condition. PMID: 25249517 [PubMed - as supplied by publisher] (Source: Perfusion)
Source: Perfusion - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Julliard W, Niles S, Maloney J Tags: Perfusion Source Type: research

Structure-function relationships and mechanical properties of pulmonary surfactant membranes.
Abstract The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a membrane-based system composed of multiple lipids and specific proteins, the primary function of which is to minimize the surface tension at the alveolar air-liquid interface, optimizing the mechanics of breathing and avoiding alveolar collapse, especially at the end of expiration. The goal of the present review is to summarize current knowledge regarding the structure, lipid-protein interactions and mechanical features of surfactant membranes and films and how these properties correlate with surfactant biological functi...
Source: Chemistry and Physics of Lipids - September 23, 2014 Category: Lipidology Authors: Parra E, Pérez-Gil J Tags: Chem Phys Lipids Source Type: research

Altered Serum Cytokine Signature in Common Variable Immunodeficiency
Conclusions Presented data suggest that the altered cytokine profile observed in patients with CVID may be attributed to the activation of monocyte-macrophage and granulocyte lineages, possibly driven by the translocation of bacterial components across the gastrointestinal or respiratory tracts mucosal barrier. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - September 23, 2014 Category: Allergy & Immunology Source Type: research

[Series] Surveillance for emerging respiratory viruses
Several new viral respiratory tract infectious diseases with epidemic potential that threaten global health security have emerged in the past 15 years. In 2003, WHO issued a worldwide alert for an unknown emerging illness, later named severe acute respiratory syndrome (SARS). The disease caused by a novel coronavirus (SARS-CoV) rapidly spread worldwide, causing more than 8000 cases and 800 deaths in more than 30 countries with a substantial economic impact. Since then, we have witnessed the emergence of several other viral respiratory pathogens including influenza viruses (avian influenza H5N1, H7N9, and H10N8; variant inf...
Source: The Lancet Infectious Diseases - September 22, 2014 Category: Infectious Diseases Authors: Jaffar A Al-Tawfiq, Alimuddin Zumla, Philippe Gautret, Gregory C Gray, David S Hui, Abdullah A Al-Rabeeah, Ziad A Memish Tags: Series Source Type: research