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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

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Lobectomy associated with better outcomes in elderly patients with early lung cancer Survival outcomes of three treatments used for early stage non-small cell lung cancer (NSCLC) was examined in this large, retrospective, population-based study (JAMA Surg 2014; doi: 10.1001/jama surg.2014.556). The authors assessed data on 9093 patients who received definitive treatment with lobectomy, sublobar resection or stereotactic ablative radiotherapy (SABR) between 2003 and 2009. Median age of the patients was 75 years. 79.3% of patients underwent lobectomy, 16.5% had sublobar resections and 4.2% received SABR. After using pro...
Source: Thorax - December 15, 2014 Category: Respiratory Medicine Authors: Lee, C. Tags: Emergency medicine, Lung neoplasms, Epidemiologic studies, Drugs: infectious diseases, Sleep disorders (neurology), Lung cancer (oncology), Lung cancer (respiratory medicine), Sleep disorders (respiratory medicine) Chest clinic Source Type: research

A critical review of the American Journal of Physiology-Lung Cellular and Molecular Physiology: 2012-2015
I have had the privilege of serving as Editor-in-Chief of the American Journal of Physiology: Lung Cellular and Molecular Physiology from 1/1/2012 to 1/1/2015 and have been reappointed for another 3-year term. When I took over as editor, I published an editorial in AJP-Lung in which I highlighted my vision and outlined the tasks to be accomplished to transform AJP-Lung into "The best place to publish basic, translational, and hypothesis-driven clinical lung research." Herein I review our accomplishments during the first term. As promised, we review each article submitted to this journal and our reviews always help the qual...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Matalon, S. Tags: PERSPECTIVES Source Type: research

CFTR and lung homeostasis
CFTR is a cAMP-activated chloride and bicarbonate channel that is critical for lung homeostasis. Decreases in CFTR expression have dire consequences in cystic fibrosis (CF) and have been suggested to be a component of the lung pathology in chronic obstructive pulmonary disease. Decreases or loss of channel function often lead to mucus stasis, chronic bacterial infections, and the accompanying chronic inflammatory responses that promote progressive lung destruction, and, eventually in CF, lung failure. Here we discuss CFTR's functional role airway surface liquid hydration and pH, in regulation of other channels such as the ...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Collawn, J. F., Matalon, S. Tags: PERSPECTIVES Source Type: research

Novel regulators of endothelial barrier function
Endothelial barrier function is an essential and tightly regulated process that ensures proper compartmentalization of the vascular and interstitial space, while allowing for the diffusive exchange of small molecules and the controlled trafficking of macromolecules and immune cells. Failure to control endothelial barrier integrity results in excessive leakage of fluid and proteins from the vasculature that can rapidly become fatal in scenarios such as sepsis or the acute respiratory distress syndrome. Here, we highlight recent advances in our understanding on the regulation of endothelial permeability, with a specific focu...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Mehta, D., Ravindran, K., Kuebler, W. M. Tags: PERSPECTIVES Source Type: research

Animal models of bronchopulmonary dysplasia. The term mouse models
The etiology of bronchopulmonary dysplasia (BPD) is multifactorial, with genetics, ante- and postnatal sepsis, invasive mechanical ventilation, and exposure to hyperoxia being well described as contributing factors. Much of what is known about the pathogenesis of BPD is derived from animal models being exposed to the environmental factors noted above. This review will briefly cover the various mouse models of BPD, focusing mainly on the hyperoxia-induced lung injury models. We will also include hypoxia, hypoxia/hyperoxia, inflammation-induced, and transgenic models in room air. Attention to the stage of lung development at...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Berger, J., Bhandari, V. Tags: CALL FOR PAPERS Source Type: research

Animal models of bronchopulmonary dysplasia. The term rat models
Bronchopulmonary dysplasia (BPD) is the chronic lung disease of prematurity that affects very preterm infants. Although advances in perinatal care have enabled the survival of infants born as early as 23–24 wk of gestation, the challenge of promoting lung growth while protecting the ever more immature lung from injury is now bigger. Consequently, BPD remains one of the most common complications of extreme prematurity and still lacks specific treatments. Progress in our understanding of BPD and the potential of developing therapeutic strategies have arisen from large (baboons, sheep, and pigs) and small (rabbits, rats...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: O'Reilly, M., Thebaud, B. Tags: CALL FOR PAPERS Source Type: research

Animal models of bronchopulmonary dysplasia. The preterm and term rabbit models
Bronchopulmonary dysplasia (BPD) is an important lung developmental pathophysiology that affects many premature infants each year. Newborn animal models employing both premature and term animals have been used over the years to study various components of BPD. This review describes some of the neonatal rabbit studies that have contributed to the understanding of BPD, including those using term newborn hyperoxia exposure models, premature hyperoxia models, and a term newborn hyperoxia model with recovery in moderate hyperoxia, all designed to emulate aspects of BPD in human infants. Some investigators perturbed these models...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: D'Angio, C. T., Ryan, R. M. Tags: CALL FOR PAPERS Source Type: research

Animal models of bronchopulmonary dysplasia. The preterm baboon models
Much of the progress in improved neonatal care, particularly management of underdeveloped preterm lungs, has been aided by investigations of multiple animal models, including the neonatal baboon (Papio species). In this article we highlight how the preterm baboon model at both 140 and 125 days gestation (term equivalent 185 days) has advanced our understanding and management of the immature human infant with neonatal lung disease. Not only is the 125-day baboon model extremely relevant to the condition of bronchopulmonary dysplasia but there are also critical neurodevelopmental and other end-organ pathological features ass...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Yoder, B. A., Coalson, J. J. Tags: CALL FOR PAPERS Source Type: research

Cigarette smoke enhances proliferation and extracellular matrix deposition by human fetal airway smooth muscle
In this study, we used canalicular-stage (18–20 wk gestational age) human fetal airway smooth muscle (fASM) cells as an in vitro model of the immature airway. fASM cells were exposed to cigarette smoke extract (CSE; 0.5–1.5% for 24–72 h), and cell proliferation, ECM deposition, and intracellular calcium ([Ca2+]i) responses to agonist (histamine 10 μM) were used to evaluate effects on remodeling and hyperreactivity. CSE significantly increased cell proliferation and deposition of ECM molecules collagen I, collagen III, and fibronectin. In contrast, [Ca2+]i responses were not significantly affected by CS...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Vogel, E. R., VanOosten, S. K., Holman, M. A., Hohbein, D. D., Thompson, M. A., Vassallo, R., Pandya, H. C., Prakash, Y. S., Pabelick, C. M. Tags: ARTICLES Source Type: research

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury
This study was designed to investigate how eNOS-dependent superoxide production contributes to endothelial barrier dysfunction in inflammatory lung injury and its regulation. C57BL/6J mice were challenged with intratracheal LPS. Bronchoalveolar lavage fluid was analyzed for protein accumulation, and lung tissue homogenate was assayed for endothelial NOS content and function. Human lung microvascular endothelial cell (HLMVEC) monolayers were exposed to LPS in vitro, and barrier integrity and superoxide production were measured. Biopterin species were quantified, and coimmunoprecipitation (Co-IP) assays were performed to ide...
Source: AJP: Lung Cellular and Molecular Physiology - December 15, 2014 Category: Respiratory Medicine Authors: Wu, F., Szczepaniak, W. S., Shiva, S., Liu, H., Wang, Y., Wang, L., Wang, Y., Kelley, E. E., Chen, A. F., Gladwin, M. T., McVerry, B. J. Tags: ARTICLES Source Type: research

Sports Injury and Illness Epidemiology: Great Britain Olympic Team (TeamGB) surveillance during the Sochi 2014 Winter Olympic Games
Conclusions The risk of injury was double the risk of illness for TeamGB athletes. Overall, the rate of time-loss issues was low. Methodological considerations are important when interpreting data, and prevention strategies should focus on those issues causing the greatest risk, in terms of prevalence and severity, to athlete health and performance. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - December 15, 2014 Category: Sports Medicine Authors: Palmer-Green, D., Elliott, N. Tags: Open access, Epidemiology, Trauma, Injury Original article Source Type: research

Inhaled salbutamol does not affect athletic performance in asthmatic and non-asthmatic cyclists
Conclusions The inhalation of salbutamol induced a significant increase in resting lung function in EVH+ and EVH– athletes but this improvement in lung function did not translate to improved exercise performance. Salbutamol had no discernible effect on key ventilatory and exercise parameters regardless of EVH challenge outcome. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - December 15, 2014 Category: Sports Medicine Authors: Koch, S., MacInnis, M. J., Sporer, B. C., Rupert, J. L., Koehle, M. S. Tags: Cycling, Asthma Original article Source Type: research

Increased bronchial parasympathetic tone in elite cross-country and biathlon skiers: a randomised crossover study
Conclusions In elite skiers, cholinergic sensitivity (PD20met) had a highly significant inverse correlation to the cholinergic antagonism of inhaled ipratropium bromide, but not at all to the bronchodilating inhaled salbutamol. This markedly increased bronchial parasympathetic tone may represent an important cholinergic role in the development of skier's asthma. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - December 15, 2014 Category: Sports Medicine Authors: Stang, J., Couto, M., Carlsen, K.-H., Stensrud, T. Tags: Asthma Original article Source Type: research

Cold Exposure and Health Effects Among Frozen Food Processing Workers in Eastern Thailand
This study explored factors affecting workers' health in the frozen food industry in Thailand. Participants comprised 497 workers exposed to a cold working environment and 255 office workers who served as the controls. Data were collected by a survey on the work environment, and the interview of workers for abnormal symptoms. The exposed group had the following characteristics: 52.7% male, overall average age of 27 (SD 6.6) years old, attained elementary education (Grade 4 and Grade 6) (54.1%), married (48.9%), smokers (21.3%), alcohol consumption (31.0%), duration of work was between 1 and 5 years (65.2%), working 6 days ...
Source: Safety and Health at Work - December 15, 2014 Category: Occupational Health Source Type: research

Respiratory influenza virus infection induces intestinal immune injury via microbiota-mediated Th17 cell-dependent inflammation
Vol. 211, No. 12, November 17, 2014. Pages 2397–2410. The authors regret that some errors appeared in the original version of this article. The incorrect staining image was used in Figure 7 B. The... (Source: The Journal of Experimental Medicine)
Source: The Journal of Experimental Medicine - December 15, 2014 Category: Internal Medicine Authors: Wang, J., Li, F., Wei, H., Lian, Z.-X., Sun, R., Tian, Z. Tags: Corrections Source Type: research

Assessment of heavy metal pollution characteristics and human health risk of exposure to ambient PM2.5 in Tianjin, China
Publication date: Available online 14 October 2014 Source:Particuology Author(s): Peifei Chen , Xiaohui Bi , Jiaqi Zhang , Jianhui Wu , Yinchang Feng To examine the features of heavy metal pollution of PM2.5 (particulate matter less than 2.5μm) in Tianjin, China, as well as the exposure risk of PM2.5 to human health, we analyzed ambient PM2.5 samples collected from a campus of Nankai University in June, August, and October 2012. The concentrations of PM2.5 and heavy metals (Ni, Cu, Pb, Zn, Cr, Cd, Hg, As and Mn) in PM2.5 were analyzed by gravimetric analysis and inductively coupled plasma-mass spectrometry, respectively...
Source: Particuology - December 15, 2014 Category: Science Source Type: research

Mitochondrial cytochrome c oxidase and control of energy metabolism: measurements in suspensions of isolated mitochondria
Cytochrome c oxidase is the enzyme responsible for oxygen consumption by mitochondrial oxidative phosphorylation and coupling site 3 of oxidative phosphorylation. In this role it determines the cellular rate of ATP synthesis by oxidative phosphorylation and is the key to understanding how energy metabolism is regulated. Four electrons are required for the reduction of oxygen to water, and these are provided by the one-electron donor, cytochrome c. The rate of oxygen consumption (ATP synthesis) is dependent on the fraction of cytochrome c reduced (fred), oxygen pressure (pO2), energy state ([ATP]/[ADP][Pi]), and pH. In coup...
Source: Journal of Applied Physiology - December 15, 2014 Category: Physiology Authors: Wilson, D. F., Harrison, D. K., Vinogradov, A. Tags: ARTICLES Source Type: research

Mitochondrial cytochrome c oxidase: mechanism of action and role in regulating oxidative phosphorylation
Mitochondrial oxidative phosphorylation has a central role in eukaryotic metabolism, providing the energy (ATP) required for survival. Regulation of this important pathway is, however, still not understood, largely due to limitations in the ability to measure the essential metabolites, including oxygen (pO2, oxygen pressure), ADP, and AMP. In addition, neither the mechanism of oxygen reduction by mitochondrial cytochrome c oxidase nor how its rate is controlled is understood, although this enzyme determines the rate of oxygen consumption and thereby the rate of ATP synthesis. Cytochrome c oxidase is responsible for reducti...
Source: Journal of Applied Physiology - December 15, 2014 Category: Physiology Authors: Wilson, D. F., Vinogradov, S. A. Tags: ARTICLES Source Type: research

Dietary conjugated linoleic acid and its effect on immune response in pigs infected with the porcine reproductive and respiratory syndrome virus
Publication date: Available online 15 December 2014 Source:Research in Veterinary Science Author(s): A Pinelli-Saavedra , JR Peralta-Quintana , J Sosa-Castañeda , SY Moya-Camarena , A Burgara-Estrella , J Hernández The aim of this study was to evaluate the effects of dietary conjugated linoleic acid (CLA) on immune response in pigs infected with porcine reproductive and respiratory syndrome virus (PRRSV). A total of 18 pigs 4 weeks of age were allocated to 3 treatments, 6 per treatment: 0% CLA, 1% CLA, and 2% CLA. Serum IL-1β, IL-6 and TNF-α; lymphocyte proliferation; and IL-2, IFN-γ, IL-10, IL-4 and IL-12 in PBMCs ...
Source: Research in Veterinary Science - December 15, 2014 Category: Veterinary Research Source Type: research

Retrospective study on the occurrence of the feline lungworms Aelurostrongylus abstrusus and Troglostrongylus spp. in endemic areas of Italy
This study supports the major role of A. abstrusus in causing feline respiratory parasitism in endemic areas of Italy. Graphical abstract (Source: The Veterinary Journal)
Source: The Veterinary Journal - December 15, 2014 Category: Veterinary Research Source Type: research

Decreased facial expression variability in patients with serious cardiopulmonary disease in the emergency care setting
Conclusions With a single visual stimulus, patients with serious cardiopulmonary diseases lacked facial expression variability and surprise affect. Our preliminary findings suggest that stimulus-evoked facial expressions from emergency department patients with cardiopulmonary symptoms might be a useful component of gestalt pretest probability assessment. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - December 15, 2014 Category: Emergency Medicine Authors: Kline, J. A., Neumann, D., Haug, M. A., Kammer, D. J., Krabill, V. A. Tags: Editor's choice, Press releases, Pneumonia (infectious disease), TB and other respiratory infections, Pain (neurology), Stroke, Venous thromboembolism, Pneumonia (respiratory medicine), Pulmonary embolism Original article Source Type: research

Lung torsion
An asymptomatic 79-year-old woman with a recent history of pneumonia was referred for further investigation. Her breath sounds were decreased over the right upper chest. A chest x-ray showed decreased vascular shadows in the right upper lung field (figure 1, arrowheads), a loss of the right pulmonary artery shadow (figure 1, arrows) and attenuated translucency in the right lower lung field. CT showed backward rotation of the right pulmonary artery and vein (figure 2). Torsion of the right lung was subsequently diagnosed. The patient underwent video-assisted thoracic surgery to reposition the affected lung, and the chest x-...
Source: Emergency Medicine Journal - December 15, 2014 Category: Emergency Medicine Authors: Takada, T., Kuriyama, A. Tags: Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Pneumonia (respiratory medicine), Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ethics Images in emergency medicine Source Type: research

Admission via the emergency department in relation to mortality of adults hospitalised with community-acquired pneumonia: an analysis of the British Thoracic Society national community-acquired pneumonia audit
Conclusions Adults with CAP admitted via EDs have more comorbid illness and greater disease severity compared to those admitted via non-ED routes. Following adjustment for these differences, 30-day inpatient mortality was not associated with route of admission. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - December 15, 2014 Category: Emergency Medicine Authors: Rodrigo, C., Mckeever, T. M., Woodhead, M., Welham, S., Lim, W. S., on behalf of the British Thoracic Society Tags: Drugs: infectious diseases, Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research

Does anaphylaxis masquerade as asthma in children?
This study highlights the potential for diagnostic confusion and demonstrates the need to consider anaphylaxis in all children presenting with severe asthma. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - December 15, 2014 Category: Emergency Medicine Authors: Sargant, N., Erlewyn-Lajeunesse, M., Benger, J. Tags: Child health, Adult intensive care, Asthma Short report Source Type: research

Sleep magnetic resonance imaging with electroencephalogram in obstructive sleep apnea syndrome
ConclusionWe describe a novel mechanism of obstruction dependent on the position of soft palate. This mechanism might play an important role in selecting candidates for surgery or treatment with hypoglossal nerve stimulation. Level of Evidence2b. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - December 15, 2014 Category: ENT & OMF Authors: Pavel Kavcic, Ales Koren, Blaz Koritnik, Igor Fajdiga, Leja Dolenc Groselj Tags: Sleep Medicine Source Type: research

Clinical relevance of rhinovirus infections among adult hospitalized patients
Conclusions Human rhinovirus infections in elderly patients with co-morbid conditions are associated with hospitalizations, requiring critical or semi-critical antibiotics use. A high CURB-65 score was associated to in-hospital mortality. (Source: The Brazilian Journal of Infectious Diseases)
Source: The Brazilian Journal of Infectious Diseases - December 15, 2014 Category: Infectious Diseases Source Type: research

Presentation of primary ciliary dyskinesia in children: 30 years' experience
ConclusionPCD remains under‐recognised by health‐care workers. The combination of neonatal respiratory distress, chronic suppurative cough and rhinosinusitis was the most common documented symptom cluster at presentation in cases of PCD. A heightened awareness of the clinical features of the disease may help to lower the age at diagnosis, facilitate appropriate treatment and improve long‐term outcomes. (Source: Journal of Paediatrics and Child Health)
Source: Journal of Paediatrics and Child Health - December 15, 2014 Category: Pediatrics Authors: Patrick H Hosie, Dominic A Fitzgerald, Adam Jaffe, Catherine S Birman, Jonathan Rutland, Lucy C Morgan Tags: Original Article Source Type: research

A systematic review on tracheostomy decannulation: a proposal of a quantitative semiquantitative clinical score
Conclusions: On our knowledge, this review provides the first proposal of decannulation score system based on current literature that is hypothetical and requires to be validated in daily practice. The key point of our proposal is to give a higher value to the objective parameters coming from literature compared to less quantifiable clinical ones. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 15, 2014 Category: Respiratory Medicine Authors: Pierachille SantusAndrea GramegnaDejan RadovanovicRita RaccanelliVincenzo ValentiDimitri RabbiosiMichele VitaccaStefano Nava Source Type: research

Prognosis of patients with suspected pulmonary embolism in Buenos Aires: a prospective cohort study
Conclusions: Even when the main cause of death in PE patients is PE itself, the overall mortality is similar between PE and RPE patients. The reason for this finding could be because of the more frequent and severe comorbidities in RPE than in PE patients.Trial registration: HomeClinicalTrial.gov: NCT01372514 (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 15, 2014 Category: Respiratory Medicine Authors: Fernando VazquezMaría Posadas-MartínezFernán de QuirósDiego Giunta Source Type: research

Treatment of Slowly Growing Mycobacteria
The most common nontuberculous mycobacterial (NTM) lung pathogen, Mycobacterium avium complex (MAC), requires antibiotic treatment regimens that are long and often arduous. M kansasii is the slowly growing NTM pathogen with the most predictably successful treatment outcomes, whereas other slowly growing NTM pathogens such as M xeonpi, M szulgai, and M malmoense are less predictably responsive to antibiotic regimens. M simiae is the most difficult of the common slowly growing NTM pathogens to eradicate. Surgical intervention for slowly growing mycobacterial lung infection has proved beneficial for some patients, but the opt...
Source: Clinics in Chest Medicine - December 15, 2014 Category: Respiratory Medicine Authors: Julie V. Philley, David E. Griffith Source Type: research

Brazilian Journal of Pulmonology and Portuguese Journal of Pulmonology: Strengthening ties in respiratory science
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): Rogerio Souza , Carlos Roberto Ribeiro de Carvalho (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Portuguese Journal of Pulmonology as a journal open to a variety of respiratory research
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): A. Morais (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Tobacco control progress in Portugal: The need for advocacy and civil society leadership
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): S.B. Ravara , N. Miranda , J.M. Calheiros , F. Berteletti , L. Joossens (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Nutritional Screening of Pulmonology Department Inpatients
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): Isabel Maia , Sónia Xará , Isabel Dias , Bárbara Parente , Teresa F. Amaral Undernutrition is associated with worse clinical outcomes and so screening is recommended. Given the paucity of information on nutritional status and on the clinical impact of undernutrition in Pulmonology patients who have been hospitalized, it is of the utmost importance that it is studied. Through a longitudinal study conducted of 323 patients consecutively admitted to a Pulmonology hospital department, undern...
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Effect of a Pulmonary Rehabilitation Program on the levels of anxiety and depression and on the quality of life of patients with chronic obstructive pulmonary disease
Conclusion Although the PRP improves levels of depression and anxiety as well as the quality of life in patients with COPD, no significant correlation of these analyzed variables was observed. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Is TNF-α gene polymorphism related to pulmonary functions and prognosis as determined by FEV1, BMI, COPD exacerbation and hospitalization in patients with smoking-related COPD in a Turkish population?
Conclusion In conclusion, there was no difference between smoking-related COPD and the control group according to TNF α-308 gene polymorphism in a Caucasian population. In addition, it was shown that important determinants of prognosis of COPD such as FEV1, BMI, COPD exacerbation and hospitalization were not associated with TNF-α-308 gene polymorphism. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Environment and Health in Children Day Care Centres (ENVIRH) – Study rationale and protocol
This study comprised two phases. Phase I included an evaluation of 45 DCCs (25 from Lisbon and 20 from Oporto, targeting 5161 children). In this phase, building characteristics, indoor CO2 and air temperature/relative humidity, were assessed. A children's respiratory health questionnaire derived from the ISAAC (International Study on Asthma and Allergies in Children) was also distributed. Phase II encompassed two evaluations and included 20 DCCs selected from phase I after a cluster analysis (11 from Lisbon and 9 from Oporto, targeting 2287 children). In this phase, data on ventilation, IAQ, thermal comfort parameters, res...
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Non-invasive ventilation in the treatment of sleep-related breathing disorders: A review and update
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): A. Nicolini , P. Banfi , B. Grecchi , A. Lax , S. Walterspacher , C. Barlascini , D. Robert Non-invasive mechanical ventilation (NIV) was originally used in patients with acute respiratory compromises or exacerbations of chronic respiratory diseases as an alternative to intubation. Over the last thirty years NIV has been used during the night in patients with stable chronic lung diseases such as obstructive sleep apnea, the overlap syndrome (COPD and obstructive sleep apnea), neuromuscular ...
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Neonatal extracorporeal membrane oxygenation: Initial experience of Hospital de São João
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): G. Rocha , P. Soares , T. Henriques-Coelho , J. Correia-Pinto , J. Monteiro , H. Guimarães , R. Roncon-Albuquerque Jr. The purpose of this series is to report the initial ECMO experience of the Neonatal Intensive Care Unit of Hospital de São João. The first three clinical cases are reported. Case report 1: a 39 weeks gestational age girl with severe lung hypoplasia secondary to a bilateral congenital diaphragmatic hernia. Case report 2: a 39 weeks gestational age girl with a right congen...
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

End-stage silicosis and lung transplantation: A way forward
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): M.T. Redondo , M. Vaz , C. Damas (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Obstructive sleep apnea in women: Prevalence, risk factors and relation to menopausal status
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): A. Tavares e Castro , J.C. Duarte , J. Cravo , S. Freitas , M.J. Matos (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Diagnosis of pulmonary sequestration using imaging methods
Publication date: November–December 2014 Source:Revista Portuguesa de Pneumologia (English Edition), Volume 20, Issue 6 Author(s): Rita Gomes , Filomena Luís , Madalena Reis (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - December 15, 2014 Category: Respiratory Medicine Source Type: research

Effect of Public Disclosure on Antibiotic Prescription Rate for Upper Respiratory Tract Infections
Although antibiotics are not required for treating uncomplicated upper respiratory tract infection (URTI), which is mostly viral, they are often prescribed, fueling antibiotic resistance and loss of protective flora. Accordingly, many studies worldwide have tried to decrease inappropriate antibiotic prescribing behavior. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - December 15, 2014 Category: Internal Medicine Source Type: research