Respiratory Medicine Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 6.

Comparison of Cardiopulmonary Complications in Adult and Pediatric Epileptic Seizures: A Prelude to Understanding SUDEP (P03.132)
CONCLUSIONS: Potentially life-threatening cardio-pulmonary abnormalities (bradycardia, apnea and hypoxemia) in pediatric epileptic-seizures were associated with predictable patient/seizure characteristics. Similar findings were different in adults, probably due to different mechanisms for inducing these changes in children and adults and lower cardiorespiratory reserve in children.Supported by: A grant by the Harvard Catalyst (Grant # UL1 RR 025758) in 2010, awarded to Drs. Kothare & Pavlova.Disclosure: Dr. Singh has nothing to disclose. Dr. Pavlova has received personal compensation for activities with Takeda. Dr. Abd...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Singh, K., Pavlova, M., Abdenadder, M., Dworetzky, B., Katz, E., Loddenkemper, T., Zarowski, M., Kothare, S. Tags: P03 Epilepsy: Comorbidities and Cardiovascular Risk Source Type: research

Defining the Border-Zone between Episodic Migraine (EM) and Chronic Migraine (CM): Medical Comorbidities in the US Population (P03.110)
CONCLUSIONS: The comorbidity profiles of HFEM have much more in common with CM than with LFEM suggesting that HFEM and CM may bear a close biological relationship.Supported by: The American Migraine Prevalence and Prevention Study is funded through a research grant to the National Headache Foundation from Ortho-McNeil Neurologics, Inc., Titusville, NJ. Additional analyses were supported by a grant from Allergan Inc., Irvine, CA, to the National Headache Foundation. Abstract development was conducted independent of financial support.Disclosure: Dr. Serrano has received research support from Allergan, ENDO Pharmaceuticals, M...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Serrano, D., Buse, D., Reed, M., Pavlovic, J., Vollbracht, S., Sollars, C. M., Lipton, R. Tags: P03 Headache: Epidemiology Source Type: research

The Clinical Spectrum of Lower Motor Neuron Syndrome (P03.047)
CONCLUSIONS: Most patients with pure LMN syndrome do not have MND and surprisingly high numbers have treatable conditions which respond to therapy. Cognitive involvement, frontal release signs, and bulbar or respiratory symptoms are strongly suggestive of MND. Electrodiagnostic testing and serology may fail to identify patients with MMN, raising the question of whether patients with undifferentiated LMN syndrome should receive an empiric trial of IVIG.Disclosure: Dr. Sanderson has nothing to disclose. Dr. Arnold has nothing to disclose. Dr. Elsheikh has received research support from Abbott. Dr. Kissel has received persona...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sanderson, A., Arnold, W., Elsheikh, B., Kissel, J. Tags: P03 Anterior Horn: Spinal Muscular Atrophy and Other Motor Neuropathies Source Type: research

A Multicenter Phase II Open-Label Trial of L-Carnitine and Valproic Acid in Infants with Spinal Muscular Atrophy Type I (P03.045)
CONCLUSIONS: Recruitment/retention of sufficient numbers of type I infants for a multicenter clinical trial is feasible. A promising endpoint for measuring disease progression is time to death and/or more than 16 hours/day ventilator support per day. This study failed to support efficacy for VPA/L-carnitine in type I infants when compared to cohort of age and gender matched natural history subjects.Supported by: Families of SMA (Elk Grove Village, IL, USA). University of Utah Center for Clinical and Translational Sciences CTSA UL1RR025764 and site CTSAs at University of Utah, Johns Hopkins, Ohio State, University of Wiscon...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Swoboda, K., Krosschell, K., Crawford, T., Kissel, J., Scott, C., Schroth, M., Acsadi, G., Kishnani, P., von Kleist-Retzow, J.-C., D'Anjou, G., Smith, E., Elsheikh, B., Simard, L., Prior, T., Tran, A., LaSalle, B., Reyna, S. Tags: P03 Anterior Horn: Spinal Muscular Atrophy and Other Motor Neuropathies Source Type: research

Botulinum Toxin Treatments for Sialorrhea Can Reduce Aspiration Related Hospitalizations (P03.027)
CONCLUSIONS: Botulinum toxin is a highly efficacious method for prevention of aspiration pneumonia due to sialorrhea with few adverse effects. Botulinum toxin therapy can both improve quality of life for patients and limit hospitalization associated costs.Disclosure: Dr. Lai has nothing to disclose. Dr. Lopez has received personal compensation for activities with O2 MedTech as a consultant.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Lai, D., Lopez, J. Tags: P03 Dysautonomias Source Type: research

Autonomic Evaluation in Cardiovascular Patients Infected by Virus Hepatitis C: A Series of 35 Patients (P03.022)
CONCLUSIONS: The presence of predominantly sensory polyneuropathy in patients infected with hepatitis C virus may be associated with impaired autonomic cardiovascular. Both cardiovascular autonomic pathways are affected. However the cardiovascular efferent sympathetic branch is the most affected in this series.Disclosure: Dr. Coutinho has nothing to disclose. Dr. Dib has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Coutinho, B., Nascimento, O. Tags: P03 Dysautonomias Source Type: research

Infantile Mitochondrial Encephalomyopathy Due to a Novel Mutation in ACAD9 (P03.017)
CONCLUSIONS: ACAD9 is a complex I assembly factor whose defects have been associated with a protean clinical spectrum spanning from pure myopathy with exercise intolerance and lactic acidosis to rapidly progressive encephalomyopathy and hypertrophic cardiomyopathy. Our case contributes adds to the clinical heterogeneity of ACAD9 deficiency and confirms the importance of assembly factors in causing complex I deficiency.Disclosure: Dr. Garone has nothing to disclose. Dr. Donati has nothing to disclose. Dr. Sacchini has nothing to disclose. Dr. Calvo has nothing to disclose. Dr. Garcia-Diaz has nothing to disclose. Dr. Mootha...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Garone, C., Donati, M. A., Sacchini, M., Calvo, S., Garcia-Diaz, B., Mootha, V., DiMauro, S. Tags: P03 Child Neurology II Source Type: research

Clinical and Mutational Characteristics of SMARD1 Patients in the Netherlands (P03.014)
CONCLUSIONS: In this Dutch cohort of SMARD1 patients the key features of the disease are seen; early respiratory failure and distal muscle weakness due to a severe axonal neuropathy. A genotype fenotype correlation could not be established. Most patients died before the age of one year.Disclosure: Dr. Stalpers has nothing to disclose. Dr. Verrips has nothing to disclose. Dr. Poll-The has nothing to disclose. Dr. Cobben has nothing to disclose. Dr. Snoeck has nothing to disclose. Dr. De Coo has nothing to disclose. Dr. Brooks has nothing to disclose. Dr. Bulk has nothing to disclose. Dr. Gooskens has nothing to disclose. Dr...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Stalpers, X., Verrips, A., Poll-The, B.-T., Cobben, J. M., Snoeck, I., De Coo, I., Brooks, A., Bulk, S., Gooskens, R., Fock, A., Verschuuren-Bemelmans, C., Sinke, R., de Visser, M., Lemmink, H. Tags: P03 Child Neurology II Source Type: research

Congenital and Juvenile Myotonic Dystrophy (PD3.010)
CONCLUSIONS: In DM presenting symptoms vary greatly and correlated with size of repeat expansion. The existence of different types of myotonic dystrophy has created a need to develop a diagnostic classification, however there is no consensus about the cut off of ages.Disclosure: Dr. Castro has nothing to disclose. Dr. Gilbreath has nothing to disclose. Dr. Andersen has nothing to disclose. Dr. Iannaccone has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Castro, D., Gilbreath, H., Andersen, M., Iannaccone, S. Tags: PD3 Muscular Dystrophy Source Type: research

Infantile Encephaloneuromyopathy and Defective Mitochondrial Translation Are Due to a Homozygous RMND1 Mutation (P03.010)
CONCLUSIONS: We identified the first human mutation affecting a DUF155 protein in a family with a severe autosomal-recessive mitochondrial translation defect. Further studies are necessary to understand the function of RMND1 and its role in mitochondrial protein synthesis.Supported by: Partially supported by the Marriott Mitochondrial Disorder Clinical Research Fund. C.M.Q. is supported by National Institute of Health (NIH) grant K23 HD065871 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD). M.H. is supported by NIH grants R01 HD057543 and R01 HD056103 from the NICHD and th...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Garcia-Diaz, B., Barros, M., Sanna-Cherchi, S., Emmanuele, V., Akman, H. O., Ferreiro-Barros, C., Horvath, R., Tadesse, S., El Gharaby, N., DiMauro, S., De Vivo, D., Shokr, A., Hirano, M., Quinzii, C. Tags: P03 Child Neurology II Source Type: research

Safety and Pharmacodynamics of USL261, a Novel Formulation of Midazolam Optimized for Intranasal Administration (P02.211)
CONCLUSIONS: All doses of USL261 were well-tolerated and did not result in excessive or prolonged sedation or psychomotor impairment. These results support the further development of USL261. Supported by: Upsher-Smith Laboratories, Inc.Disclosure: Dr. Dworak has received personal compensation for activities with Upsher-Smith Laboratories, Inc. as an employee. Dr. Bancke has received personal compensation for activities with Upsher-Smith Laboratories, Inc. Dr. Halvorsen has received personal compensation for activities with Upsher-Smith Laboratories, Inc as an employee. Dr. Halvorsen holds stock in Medtronic, Stryker, Elan,...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dworak, H., Bancke, L., Halvorsen, M. Tags: P02 Epilepsy: Novel Therapeutics and Basic Science Source Type: research

Should Non-Invasive Mechanical Ventilation Be Used in Myasthenia Gravis Crisis? (P02.197)
CONCLUSIONS: Our preliminary study does not reproduce the excellent results of the 3 previously published studies. Although NIV could be an alternative to invasive MV in peculiar situations where rapid improvement can be expected, its larger use needs further prospective studies.Disclosure: Dr. Sabben has nothing to disclose. Dr. Gales has nothing to disclose. Dr. Demeret has nothing to disclose. Dr. Bolgert has nothing to disclose. Dr. Weiss has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sabben, C., Gales, A., Demeret, S., Bolgert, F., Weiss, N. Tags: P02 Myasthenia Gravis: Treatment Issues Source Type: research

A Tale of Two Eyes (P02.187)
CONCLUSIONS: Isolated bilateral sixth nerve palsy has been described in the literature and its incidence is almost equal to unilateral sixth nerve palsy. The most common causes are tumors and demyelinating lesions. Miller fisher syndrome classically presents with a triad of ataxia, opthalmoplegia and areflexia . It may present only as acute ophthalmoperesis, however this has been described in very few case reports. Rarely is the presentation isolated bilateral sixth nerve palsy as seen in our patient. It is hypothesized that infection by microorganism expressing GQ1b epitope triggers production of IgG anti-GQ1b antibodies....
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mittal, S., Imperioli, M., Silverman, I. Tags: P02 Peripheral Nerve: Basic Science and Diagnostics Source Type: research

Hemiplegic Form of Amyotrophic Lateral Sclerosis (ALS) with Cognitive Changes: An Autopsy Study (P02.176)
CONCLUSIONS: Our results suggest that despite the atypical clinical features of Hemiplegic ALS, pathology suggests that the findings are typical for what is found in patients with classical ALS.Disclosure: Dr. Chugh has nothing to disclose. Dr. Shahbazi has nothing to disclose. Dr. Lange received financial support for research activities from CSL Behring, GlaxoSmithKline, and Cytokinetics.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Chugh, A., Shahbazi, M., Lange, D. Tags: P02 Anterior Horn: Basic Science Source Type: research

Peripheral Blood Mononuclear Cells - Platelets Aggregates and the Levels of Selectins in Lung Cancer Patients with Consideration of Paraneoplastic Neurological Syndromes (P02.162)
CONCLUSIONS: L-Selectin up-regulation associates both with PBMC-platelets aggregates formation, with the presence of well-defined onconeural antibodies and non-classical PNS manifestation.Disclosure: Dr. Michalak has nothing to disclose. Dr. Stefens-Stawna has nothing to disclose. Dr. Wysocka has nothing to disclose. Dr. Piorunek has nothing to disclose. Dr. Batura-Gabryel has nothing to disclose. Dr. Cymerys has nothing to disclose. Dr. Kozubski has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Michalak, S., Stefens-Stawna, P., Wysocka, E., Piorunek, T., Batura-Gabryel, H., Cymerys, M., Kozubski, W. Tags: P02 Neuro-Oncology: Basic Science Source Type: research

Adult-Onset Autosomal Dominant Leukodystrophy as a Multiple Sclerosis Mimic (P02.110)
CONCLUSIONS: Adult-onset ADLD is characterized by early autonomic dysfunction and diffuse white matter disease in patients with a family history suggesting autosomal dominant inheritance. Ataxia and cognitive changes are variably seen. Unlike in MS, white matter lesions in ADLD are symmetrical and have a preference for the corticospinal tracts and brainstem with sparing of the cortex, corpus callosum and periventricular regions. Thorough history taking and careful MRI analysis in our patient prompted appropriate genetic testing and subsequent family counseling.Disclosure: Dr. Beary has nothing to disclose. Dr. Conway has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Beary, J., Conway, D. Tags: P02 Pediatric MS and Other Diseases Source Type: research

A Novel Mutation in the Mitochondrial DNA Cytochrome B Gene (MTCYB) in a Patient with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke like Episodes Syndrome (P02.088)
CONCLUSIONS: This case demonstrates that MTCYB must be included in the already long list of mitochondrial DNA genes that have been associated with the MELAS phenotype.Supported by: Grant from the National Institutes of Health (HD32062) and by the Marriott Mitochondrial Disorder Clinical Research Fund (MMDCRF). PGR is supported by a postdoctoral fellowship from Ministerio de Educacion y Ciencia, Spain.Disclosure: Dr. Emmanuele has nothing to disclose. Dr. Sotiriou has nothing to disclose. Dr. Gutierrez Rios has nothing to disclose. Dr. Ganesh has nothing to disclose. Dr. Ichord has nothing to disclose. Dr. Foley has nothing...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Emmanuele, V., Sotiriou, E., Gutierrez Rios, P., Ganesh, J., Ichord, R., Foley, A. R., Akman, O., DiMauro, S. Tags: P02 Child Neurology I Source Type: research

Cerebellar Ataxia with Hypogonadism: Delineating a New Group of Inherited Neurometabolic Disorders (P02.081)
CONCLUSIONS: Our study reinforces that the association between cerebellar ataxia and hypogonadism comprise hetereogenous entities. Clinical investigation of further cases with this association surely can enlighten the pathological basis of these fascinating neuroendocrinological syndromes.Disclosure: Dr. Lourenco has nothing to disclose. Dr. Sobreira has nothing to disclose. Dr. Zuchner has received (royalty or license fee or contractual rights) payments from Athena Diagnostics. Dr. Marques has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Lourenco, C., Sobreira, C., Zuchner, S., Marques, W. Tags: P02 Ataxia, Parkinson ' s Disease, and Dystonia Source Type: research

Sleep Apnea in Acute Stroke (P02.032)
CONCLUSIONS: There is a high prevalence of sleep apnea in the patients with acute stroke. Having inpatient screening of these stroke patients might help capture more patients early and start treatment for sleep apnea to control one of the important modifiable risk factor of strokes. Disclosure: Dr. Morgan has nothing to disclose. Dr. Sheth has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Morgan, A., Sheth, S. Tags: P02 Cerebrovascular Disease II Source Type: research

Predictive Risk Factors of In-Hospital Mortality Following Acute Stroke in the United States: Data from the Nationwide Inpatient Database, 2006-2010 (P02.015)
CONCLUSIONS: The rate of in-hospital mortality is relatively high following acute stroke (8.42%). We identified multiple risk factors of in-hospital mortality in acute stroke patients. The strongest risk factor is the type stroke (hemorrhagic). The present finding suggests that patients at increased risk of mortality can be identified and additional treatment for prevention might be warranted.Disclosure: Dr. Naderi has nothing to disclose. Dr. Abcede has nothing to disclose. Dr. Al-Khoury has nothing to disclose. Dr. Mozaffar has received personal compensation for activities with California Stem Cell Inc., NuFactor, Cresce...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Naderi, N., Abcede, H., Al-Khoury, L., Mozaffar, T., Jain, V. Tags: P02 Cerebrovascular Disease II Source Type: research

First Human Dosing Experience with TRV130, a Biased Ligand at the Mu Opioid Receptor (P02.013)
CONCLUSIONS: TRV130 is a novel mu opioid receptor G-biased ligand which exhibited excellent PK, PD and tolerability. Additional studies are planned to continue development of TRV130 for post-operative analgesia and to explore the feasibility of developing a transdermal formulation.Supported by: Trevena, Inc.Disclosure: Dr. Soergel has received personal compensation for activities with Trevena, Inc. as an employee. Dr. Subach has received personal compensation for activities with Trevena, Inc. as an employee. Dr. Violin has received personal compensation for activities with Trevena, Inc. as an employee. Dr. Yamashita has re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Soergel, D., Subach, R. A., Violin, J., Yamashita, D., Gowen, M., Lark, M. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Futility, Miracles, and Religion: A Game Theory Display of a Medical Ethics Dilemma (P02.006)
CONCLUSIONS: Although this situation does not describe a Prisoner's Dilemma, that game theory format of payoff presentation demonstrates that ethical dilemmas in clinical medicine (such as this described situation involving futility and religious belief in miraculous healing) can be illustrated and the issues focused when displayed using a perceived payoff format.Disclosure: Dr. Riggs has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Riggs, J. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Efficacy of Dexpramipexole in Amyotrophic Lateral Sclerosis: Data from the Phase III EMPOWER Trial (PL02.004)
CONCLUSIONS: EMPOWER aims to extend the preliminary findings from the dexpramipexole Phase II study and provide definitive results regarding its efficacy in individuals with ALS.Supported by: Biogen Idec, Inc.Disclosure: Dr. Cudkowicz has received personal compensation for activities with GlaxoSmithKline, Inc. and Teva Neuroscience. Dr. Cudkowicz has received research support from Biogen Idec and Neuraltis. Dr. Van den Berg has received personal compensation for activities with Baxter, Biogen Idec and Cytokinetics as a consultant and/or participant on an advisory board. Dr. Shefner has received personal compensation for ac...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Cudkowicz, M., Van den Berg, L., Shefner, J., Mitsumoto, H., Mora, J., Ludolph, A., Hardiman, O., Ingersoll, E., Archibald, D., Meyers, A., Dong, Y., Farwell, W., Kerr, D. Tags: PL02 Clinical Trials Plenary Session Source Type: research

Phase 2 BOLD Extension Study Safety Results for Siponimod (BAF312) in Patients with Relapsing-Remitting Multiple Sclerosis (P01.176)
CONCLUSIONS: Siponimod was well tolerated during the first 12 months of extension, in line with the core trial, and no new safety signals were observed.Supported by: Novartis Pharma AG.Disclosure: Dr. Hartung has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Sanofi-Aventis Pharmaceuticals, Inc., Bayer, Novartis, and Merck Serono. Dr. Selmaj has received personal compensation for activities with Biogen Idec, Genzyme, Ono Pharmaceutical, Novartis, Bayer, Hoffmann LaRoche, Merck, Serono and Synthon. Dr. Li has received personal compensation for activities with Genzyme, Novartis, and Nuron ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hartung, H.-P., Selmaj, K., Li, D., Hemmer, B., Freedman, M., Stuve, O., Rieckmann, P., Montalban, X., Ziemssen, T., Zhang-Auberson, L., Hunter, B., Rochotte, E., Wallstrom, E., Kappos, L. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Comparison of Infection Risk with Alemtuzumab and SC IFNB-1a in Patients with Multiple Sclerosis Who Experienced Disease Activity While on Prior Therapy (CARE-MS II) (P01.172)
CONCLUSIONS: Although alemtuzumab increased the risk for infection compared with IFNB-1a in CARE-MS II, all infections were manageable, few were serious, and none led to study discontinuation.Supported by: Genzyme, a Sanofi company and Bayer Healthcare Pharmaceuticals.Disclosure: Dr. Wray has received personal compensation for activities with Serono, Inc., Bayer Pharmaceuticals Corporation, Genzyme Corporation, Biogen Idec, Novartis and Teva Neuroscience as a consultant, speaker and/or serving on an advisory board. Dr. Wray has received research support from Accorda, Biogen Idec, Elan, Genzyme, Novartis, Ono, Roche and Ser...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Wray, S., Arnold, D., Cohen, J., Coles, A., Confavreux, C., Fox, E., Hartung, H., Havrdova, E., Selmaj, K., Weiner, H., Miller, T., Twyman, C., Lake, S., Margolin, D., Panzara, M., Compston, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Frequency of Infections during Treatment with Teriflunomide: Pooled Data from Three Placebo-Controlled Teriflunomide Studies (P01.171)
CONCLUSIONS: Teriflunomide had a low incidence of serious infections, which was not different from placebo. Mean reductions in WBC counts were small in magnitude, often stabilized during treatment, and were not associated with infections. These findings provide evidence that risk of infection is not increased by teriflunomide treatment.Supported by: Genzyme, a Sanofi company.Disclosure: Dr. Singer has received personal compensation for activities with Acorda, Bayer, Biogen Idec, EMD Serono, Genentech, Genzyme, Novartis, Pfizer and Teva as a speaker or consultant. Dr. Singer has received research support from Biogen-Idec, G...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Singer, B., Comi, G., Miller, A., Olsson, T., Wolinsky, J., Kappos, L., Confavreux, C., Freedman, M., Benzerdjeb, H., Li, H., Truffinet, P., O'Connor, P. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Long-Term Efficacy, Safety and Tolerability of Ponesimod in Patients with Relapsing-Remitting Multiple Sclerosis (P01.156)
CONCLUSIONS: Long-term treatment with ponesimod maintained efficacy on clinical and MRI outcomes; efficacy on both measures was re-affirmed in ex-placebo patients. No new safety findings were identified.Supported by: Actelion Pharmaceuticals Ltd.Disclosure: Dr. Freedman has received personal compensation for activities with Bayer, Biogen Idec, Teva, Merck Serono, Novartis, Sanofi, and Celgene. Dr. Freedman's institution has received research support from Bayer Healthcare and Genzyme. Dr. Boster has received personal compensation from Merck Serono, Biogen, Novartis, Sun-Pharma, Roche, Genetech, National MS Society, NIH, and...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Freedman, M., Boster, A., Fernandez, O., Melanson, M., Pozzilli, C., D'Ambrosio, D., Sidorenko, T., Olsson, T. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Variants, Clinical Characteristics and Prognostic Factors of Guillain Barre Syndrome in Chinese (P01.135)
CONCLUSIONS: Miller Fisher syndrome is more common in the Chinese population compared to the West. Necessity of mechanical ventilation during hospitalization is an independent predictor of poor functional recovery and the Erasmus GBS Outcome Score is a useful score in predicting functional recovery.Disclosure: Dr. Kwok has nothing to disclose. Dr. Tsui has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Chang has nothing to disclose. Dr. Hon has nothing to disclose. Dr. Mak has nothing to disclose. Dr. Cheung has nothing to disclose. Dr. Ho has nothing to disclose. Dr. Chan has ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kwok, K., Tsui, K., Wong, D., Wong, Y. K., Chang, R., Hon, S., Mak, W., Cheung, R., Ho, S. L., Chan, K. H., Lau, G. Tags: P01 Peripheral Nerve: Acute Inflammatory and Nutritional Source Type: research

The Day George Avellis Met Miller Fisher - About the Unsual Presentation of an Anti-GQ1b IgG Antibody Syndrome (P01.133)
CONCLUSIONS: This case highlights that (i) MFS can show atypical presentation (here a pure Avellis syndrome, never reported in the context of the anti-GQ1b syndrome to our knowledge) and should be considered in front of an isolated impaired cranial nerve function, even in the absence of the classical triad of ophtalmoplegia, areflexia and ataxia, and (ii) that the boundaries between MFS and GBS are usually neater in textbooks than in real life.Disclosure: Dr. Phan-Ba has received personal compensation for activities with Genzyme, Merck, and Biogen Idec. Dr. Parmentier has nothing to disclose. Dr. Lievens has nothing to dis...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Phan-Ba, R., Parmentier, E., Lievens, I., Maquet, P., Moonen, G. Tags: P01 Peripheral Nerve: Acute Inflammatory and Nutritional Source Type: research

Serum False Positive Botulism in a Case with Miller Ficher Syndrome (P01.120)
CONCLUSIONS: These findings might suggest either a role of the Anti GQ1b antibodies or antibodies found in MFS to be toxic to mouse. Above can also mean similar site of actions of the antibodies or suggest possible cross reactivity of the antibodies with botulinum toxin. If this true than we might be able to imply that there is a possible role of botulinum toxin in treatment or management of MFS or vice versa.Disclosure: Dr. Zeylikman has nothing to disclose. Dr. Campellone has received personal compensation for activities with Allergan, Inc. and Teva Neuroscience. Dr. Mirsen has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zeylikman, Y., Campellone, J., Mirsen, T. Tags: P01 Muscle Disease: Other Source Type: research

Levetiracetam Related Encephalopathy with Opsoclonus and Triphasics (P01.045)
CONCLUSIONS: There are rare reports of toxic encephalopathy due to levetiracetam. Our case has unique manifestations of opsoclonus with triphasic waves on EEG. There should be high index of suspicion in individuals with renal impairment on stable or even adjusted doses of levetiracetam.Disclosure: Dr. Putta has nothing to disclose. Dr. Talwar has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Putta, S., Talwar, D. Tags: P01 Epilepsy: Therapeutics Source Type: research

Shoshin Beriberi Heralding Thiamine Deficiency as a Mimic of Guillain-Barre Syndrome (P01.031)
CONCLUSIONS: A high index of suspicion for thiamine deficiency in patients presenting with progressive neuropathy is important as there is significant overlap with GBS. Development of hypotension, tachycardia, lactic acidosis, mental status changes, or extraocular muscle paresis in cases of possible GBS should prompt consideration of thiamine deficiency.Disclosure: Dr. Panara has nothing to disclose. Dr. Arnold has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Panara, R., Arnold, W. Tags: P01 Neurocritical Care: Clinical Neurophysiology/Therapeutics Source Type: research

Teriflunomide Efficacy and Safety in Patients with Relapsing Multiple Sclerosis: Results from TOWER, a Second, Pivotal, Phase 3 Placebo-Controlled Study (S01.004)
CONCLUSIONS: Teriflunomide 14mg significantly reduced ARR and 12-week disability progression compared with placebo; 7mg significantly reduced ARR. Teriflunomide has a well-characterized safety profile. These results confirm those of TEMSO and support teriflunomide as a treatment option for patients with RMS.Supported by: Genzyme, a Sanofi company.Disclosure: Dr. Miller has received personal compensation for activities with Acorda Therapeutics, Biogen Idec, GlaxoSmithKline, Merck Serono, Novartis, Nuron Biotech, ONO, Genzyme/Sanofi, Questcor, Teva Neuroscience, and Accordant Health Services. Dr. Miller has received personal...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Miller, A., Kappos, L., Comi, G., Confavreux, C., Freedman, M., Olsson, T., Wolinsky, J., Bagulho, T., Delhay, J.-L., Zheng, Y., Truffinet, P., O'Connor, P. Tags: S01 Multiple Sclerosis: Clinical Trials I Source Type: research

A comparison of inspiratory airflow dynamics during sleep between upper airway resistance syndrome patients and healthy controls.
CONCLUSIONS: Our findings indicate a less-than-robust difference in respiratory parameters during sleep between UARS patients and healthy controls and no difference in standard sleep parameters or sleep fragmentation. We consider a pathophysiology of UARS that incorporates these findings. PMID: 23407917 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - February 14, 2013 Category: Sleep Medicine Authors: Gold AR, Broderick JE, Gold MS, Amin MM Tags: Sleep Breath Source Type: research

Pharmacokinetics, pharmacodynamics and therapeutics of pradofloxacin in the dog and cat
Pradofloxacin is a third‐generation fluoroquinolone, licensed in the EU for use in a range of indications in the dog and cat and authorized more recently in the USA for one therapeutic indication (skin infections) in the cat. This review summarizes and appraises current knowledge on the physico‐chemical, pharmacological [pharmacokinetics (PK) and pharmacodynamics (PD)], safety and therapeutic properties of pradofloxacin in the target species. Pradofloxacin contains two centres of asymmetry and is the pure SS enantiomer. After oral dosing of tablets (dog) or tablets and oral suspension (cat), maximum plasma concentratio...
Source: Journal of Veterinary Pharmacology and Therapeutics - February 14, 2013 Category: Veterinary Research Authors: P. Lees Tags: Review Article Source Type: research

Reversible tetraplegia after percutaneous nephrostolithotomy and septic shock. A case of critical illness polyneuropathy and myopathy with acute onset and complete recovery: CIP and CIM after PNL
Conclusion: This case expands our understanding of the complications of PNL and underscores the importance of differentiating CIP/CIM from GBS in case of such patients developing weakness after the treatment. Clinical characteristics and examination results should be carefully evaluated to make the diagnosis of CIP or CIM. Both anti-septic prophylaxis and control of hyperglycemia might be effective for the prevention of CIP or CIM; aggressive treatment on sepsis and multiple organ failure is considered to be the most effective measure to reduce the incidence of CIP/CIM.
Source: BMC Nephrology - February 14, 2013 Category: Urology & Nephrology Authors: Hai LiLi-Min WuXiang-Bo KongYi HouRui ZhaoHong-Yan LiHong-Liang Zhang Source Type: research

Self‐navigated tissue phase mapping using a golden‐angle spiral acquisition—proof of concept in patients with pulmonary hypertension
ConclusionThe feasibility of measuring myocardial motion using a golden‐angle spiral TPM sequence was demonstrated, with an image‐based respiratory navigator calculated from the TPM data itself. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc.
Source: Magnetic Resonance in Medicine - February 14, 2013 Category: Radiology Authors: Jennifer A. Steeden, Daniel S. Knight, Shreya Bali, David Atkinson, Andrew M. Taylor, Vivek Muthurangu Tags: Full Paper Source Type: research

Melatonin: helping to MEND impaired sleep
Many neurodevelopmental disorders adversely affect sleep; children often have difficulty in falling asleep, wake up more often during the night, and sleep less than their typically developing peers. ‘Sleep problems’ were found in 53% of over 300 children with autism, compared with 44% of 63 children with delayed development, and 32% of 163 children with normal (typical) development.1 Sleep problems arise from complex interactions between biological, psychological, social, family and cultural factors. Circadian sleep rhythm disorders (CSRD) may be acute but are more often chronic, and frequently result in associ...
Source: Archives of Disease in Childhood - February 14, 2013 Category: Pediatrics Authors: Appleton, R. E., Gringras, P. Tags: Clinical trials (epidemiology), ADC Paediatric and Perinatal Drug Therapy, Sleep disorders (neurology), Child and adolescent psychiatry (paedatrics), Autism, Pervasive developmental disorder, Sleep disorders, Disability, Sleep disorders (respiratory medic Source Type: research

Seasonal variability in paediatric obstructive sleep apnoea
Conclusions We identified more severe obstructive sleep apnoea in clinically referred children during winter and spring and suggest that inflammation from respiratory viruses may contribute to adenotonsillar hypertrophy, worsening airway obstruction. Clinicians should take season into account when interpreting PSG results.
Source: Archives of Disease in Childhood - February 14, 2013 Category: Pediatrics Authors: Walter, L. M., Nisbet, L. C., Nixon, G. M., Davey, M. J., Anderson, V., Trinder, J., Walker, A. M., Horne, R. S. C. Tags: Immunology (including allergy), Sleep disorders (neurology), Child health, Sleep disorders, Airway biology, Sleep disorders (respiratory medicine) Short research reports Source Type: research

The Carbon brace
Conclusions: The CMCR brace is innovative for several reasons:The use of prestressed carbon to correct deformations without preventing chest movements and thus preserve respiratory capacity with brace.The use of Orten(R) computer system to obtain the trunk print, which allows a follow-up of aesthetic evolution from the beginning to the end of treatment. [1]The use of mobile pads to gradually correct scoliosis, by conforming to stiffness areas that will appear throughout the patient growth.The use of 3D radiological analysis before brace design and at the late adaptation to get an optimal correction of scoliosis, using mini...
Source: Scoliosis - February 14, 2013 Category: Orthopaedics Authors: Jean-Claude BernardCyril LecanteJulie DeceuninckGregory NotinLydie JournoudFrederic Barral Source Type: research

New clinical and molecular insights on Barth syndrome
Conclusions: Lactic acidosis associated with 3-methylglutaconic aciduria is highly suggestive of BS, whilst the severity of the metabolic decompensation at disease onset should be considered for prognostic purposes. Mutation analysis of the TAZ gene is necessary for confirming the clinical and biochemical diagnosis in probands in order to identify heterozygous carriers and supporting prenatal diagnosis and genetic counseling.
Source: Orphanet Journal of Rare Diseases - February 14, 2013 Category: Internal Medicine Authors: Lorenzo FerriMaria DonatiSilvia FunghiniSabrina MalvagiaSerena CatarziLicia LugliLuca RagniEnrico BertiniFrédéric VazDavid CooperRenzo GuerriniAmelia Morrone Source Type: research

Alpha neurotoxins.
Abstract α-Neurotoxins have been isolated from hydrophid, elapid and, more recently, colubrid snake venoms. Also referred to as postsynaptic neurotoxins or 'curare' mimetic neurotoxins, they play an important role in the capture and/or killing of prey by binding to the nicotinic acetylcholine receptor on the skeletal muscle disrupting neurotransmission. They are also thought to cause respiratory paralysis in envenomed humans. This review will discuss the historical background into the discovery, isolation, structure and mechanism of action of the α-neurotoxins, including targets and cellular outcomes, and then wi...
Source: Toxicon - February 13, 2013 Category: Toxicology Authors: Barber CM, Isbister GK, Hodgson WC Tags: Toxicon Source Type: research

Survey About the Use of Lung Function Testing in Public Hospitals in Catalonia in 2009.
CONCLUSIONS: The results of this study have identified areas for improvement in spirometry programs. PMID: 23414603 [PubMed - as supplied by publisher]
Source: Archivos de Bronconeumologia - February 13, 2013 Category: Respiratory Medicine Authors: Roger N, Burgos F, Giner J, Rosas A, Tresserras R, Escarrabill J, el grupo de trabajo de Función Pulmonar del Plan Director de las Enfermedades del Aparato Respiratorio (PDMAR) Tags: Arch Bronconeumol Source Type: research

Highly efficient 3D motion-compensated abdomen MRI from undersampled golden-RPE acquisitions.
CONCLUSION: Our method reduces scan time by 56 % compared to the gating technique while similar image quality is preserved. PMID: 23404682 [PubMed - as supplied by publisher]
Source: Magma - February 13, 2013 Category: Radiology Authors: Buerger C, Prieto C, Schaeffter T Tags: MAGMA Source Type: research

[Application of the recommendations of the conference of consensus in front of symptoms ENT, respiratory or thoracic pains considered as due to a gastroesophageal reflux disease.]
CONCLUSION: There is a considerable difference between the recommendations of the French-Belgian Consensus Conference on adult GERD and the practices observed in general medicine. The diagnostic and therapeutic approaches were empirical with recourse to additional exams in less than 10% of cases. The degree of certainty as to GERD accountability was based primarily on response to PPI treatment. PMID: 23414966 [PubMed - as supplied by publisher]
Source: Presse Medicale - February 13, 2013 Category: Journals (General) Authors: Vallot T, Ducrotte P, Bour B, Jacques JP, Houcke P, De Korwin JD, Pariente A, Aygalenq P, Coudsy B, Carrois F, Ricci L, Bruley des Varannes S Tags: Presse Med Source Type: research

Genomic sequencing reveals mutations potentially related to the over-attenuation of a highly pathogenic porcine reproductive and respiratory syndrome virus.
In this study, we analyzed the genomic and antigenic variants of HP-PRRSV strain JXA1 during in vitro passage. Protective efficacies of passages 100, 110, 120, 140 and 170 of JXA1 against the high virulence parental virus were evaluated by inoculating pigs with each of these viruses then challenging with the passage 5 of JXA1 at 28 days post immunization. We found the antigenicities of passages after 110 were significantly reduced. Inoculation with passages after 110 only provided insufficient protection against the parental strain challenge, indicating that the immunogenicity of JXA1 was significantly decreased when it's ...
Source: Clinical and Vaccine Immunology - February 13, 2013 Category: Allergy & Immunology Authors: Yu X, Chen N, Deng X, Cao Z, Han W, Hu D, Wu J, Zhang S, Wang B, Gu X, Tian K Tags: Clin Vaccine Immunol Source Type: research

Arthroscopic shoulder surgery under general anesthesia with brachial plexus block : Postoperative respiratory dysfunction of combined obstructive and restrictive pathology.
CONCLUSION: Shoulder arthroscopic surgery under GA with BPB induced both restrictive and obstructive pathologies. It is important to maintain a high level of awareness for the potential negative respiratory effects of this surgery especially for subjects with pre-existing cardiopulmonary disease. The measurements in this study would be useful to monitor the risk of respiratory dysfunction in these patients. PMID: 23400711 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - February 13, 2013 Category: Anesthesiology Authors: Gwak MS, Kim WH, Choi SJ, Lee JJ, Ko JS, Kim GS, Kim YI, Kim MH Tags: Anaesthesist Source Type: research

ECMO-assisted esophagectomy after left  pneumonectomy.
Conclusions: This technique may be an excellent option for the treatment of complex situations such as esophagectomy after pneumonectomy. PMID: 23404644 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - February 13, 2013 Category: Transplant Surgery Authors: Xu HC, Ye P, Bao FC, Pan H, Yang YH, Wang LM, Wang ZT, Li ZB, He ZH, Han WL, Wang YQ, Hu J Tags: Int J Artif Organs Source Type: research

Suicide by Self-Administration of a Drug Mixture (Propofol, Midazolam, and Zolpidem) in an Anesthesiologist: The First Case Report in Italy.
Abstract The authors report an unusual case of suicide of an anesthesiologist, in which the suicide manner and means depend upon the victim's occupation. This is the first case report published in Italy of a death involving propofol and other drugs. The anesthesiologist was found dead with an empty drip still inserted in the hand and another one near his body. Forensic and toxicological findings suggested that the cause of death was a respiratory depression due to a self-administration of a rapidly infused lethal drug mixture. Analytical drug quantification was performed by gas chromatography-mass spectrometry. Blo...
Source: Journal of Forensic Sciences - February 13, 2013 Category: Forensic Medicine Authors: Colucci AP, Gagliano-Candela R, Aventaggiato L, De Donno A, Leonardi S, Strisciullo G, Introna F Tags: J Forensic Sci Source Type: research

Evaluation of nasal epithelium sampling as a tool in the preclinical development of siRNA-based therapeutics for asthma.
Abstract The development of siRNA-based asthma therapeutics is currently hampered by a paucity of relevant biomarkers and the need to ascertain tissue-specific gene targeting in the context of active disease. Epithelial STAT6 expression is fundamental to asthma pathogenesis in which inflammatory changes are found throughout the respiratory tract. Therefore, to improve preclinical evaluation, we tested the efficacy of STAT6-targeting siRNA within nasal epithelial cells (NEC's) obtained from asthmatic and non-asthmatic donors. STAT6 expression was invariant in both donor groups and amenable to suppression by siRNA tr...
Source: J Cell Mol Med - February 13, 2013 Category: Molecular Biology Authors: Healey GD, Evans N, Hopkin JM, Davies G, Walker W Tags: J Cell Mol Med Source Type: research