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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Nonsteroidal anti-inflammatory drugs in community-acquired pneumonia
We read with interest the editorial by Riccard and Medissa [1], which accompanied the paper by Tagami et al. [2] that reviewed the effects of corticosteroids on mortality in community-acquired pneumonia (CAP). (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Crawford, E., Allen, M., Mustfa, N., Stone, H. Tags: Respiratory infections and tuberculosis Original Articles: Correspondence Source Type: research

Nonsteroidal anti-inflammatory drugs in community-acquired pneumonia
We read with attention the letter by E. Crawford and co-workers and thank them for their interests in our work. (Source: European Respiratory Journal)
Source: European Respiratory Journal - August 31, 2015 Category: Respiratory Medicine Authors: Ricard, J.-D., Messika, J. Tags: Respiratory infections and tuberculosis Original Articles: Correspondence Source Type: research

Rare pulmonary diseases and orphan drugs: where do we stand and where are we going to?
Rare diseases are a major problem for the patients who suffer from them, for their families and for selected specialists involved in their management. In addition, they cause economic, social and public health problems that should be acknowledged and discussed by the medical and scientific community. Because of the rarity of these illnesses, the experience of most physicians is usually limited to a few cases. Nevertheless, the essential steps in the diagnosis and management of a patient who is suspected to have, for example, an interstitial lung disease or pulmonary hypertension, should be common knowledge, as these diseas...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Harari, S., Humbert, M., Blasi, F., Collard, H. R., Matucci-Cerinic, M., Simonneau, G., Vancheri, C., Wells, A. U., Cottin, V. Tags: Interstitial and orphan lung disease Editorial Source Type: research

Integration of interventional bronchoscopy in the management of lung cancer
Tracheal or bronchial proximal stenoses occur as complications in 20–30% of lung cancers, resulting in a dramatic alteration in quality of life and poor prognosis. Bronchoscopic management of these obstructions is based on what are known as "thermal" techniques for intraluminal stenosis and/or placement of tracheal or bronchial prostheses for extrinsic compressions, leading to rapid symptom palliation in the vast majority of patients. This invasive treatment should only be used in cases of symptomatic obstructions and in the presence of viable bronchial tree and downstream parenchyma. This review aims to clarify 1) t...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Guibert, N., Mazieres, J., Marquette, C.-H., Rouviere, D., Didier, A., Hermant, C. Tags: Pulmonary pharmacology and therapeutics, Lung cancer European Respiratory Update Source Type: research

Coagulation and anticoagulation in idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulation and fibrinolytic systems play central roles in wound healing and repair, processes hypothesised to be abnormal within the IPF lung. Animal models of pulmonary fibrosis have demonstrated an imbalance between thrombosis and fibrinolysis within the alveolar compartment, a finding that is also observed in IPF patients. A systemic prothrombotic state also occurs in IPF and is as...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Crooks, M. G., Hart, S. P. Tags: Interstitial and orphan lung disease, Pulmonary pharmacology and therapeutics, Mechanisms of lung disease Mini-Review Source Type: research

Pulmonary hypertension in patients with chronic myeloproliferative disorders
Pulmonary hypertension (PH) is a major complication of several haematological disorders. Chronic myeloproliferative diseases (CMPDs) associated with pulmonary hypertension have been included in group five of the clinical classification for pulmonary hypertension, corresponding to pulmonary hypertension for which the aetiology is unclear and/or multifactorial. The aim of this review is to discuss the epidemiology, pathogenic mechanism and treatment approaches of the more common forms of pulmonary hypertension in the context of CMPD's: chronic thromboembolic pulmonary hypertension, precapillary pulmonary hypertension and dru...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Adir, Y., Elia, D., Harari, S. Tags: Interstitial and orphan lung disease, Pulmonary vascular disease Reviews Source Type: research

Interstitial lung disease in systemic sclerosis: where do we stand?
Interstitial lung disease (ILD) is common in systemic sclerosis (SSc) patients and despite recent advances in the treatment is, at present, the major cause of death. Today, an early diagnosis of ILD is possible, and is mandatory to improve the prognosis of the disease. Pulmonary function tests and high-resolution computed tomography remain the mainstay for the diagnosis of SSc-ILD, but there is a growing interest in lung ultrasound. Recently, the correlation between severity of fibrosis and some peripheral blood biomarkers has been described. Nonselective immunosuppressors are still the main treatment for ILD, with cycloph...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Cappelli, S., Bellando Randone, S., Camiciottoli, G., De Paulis, A., Guiducci, S., Matucci-Cerinic, M. Tags: Interstitial and orphan lung disease Reviews Source Type: research

Idiopathic pulmonary fibrosis: from clinical trials to real-life experiences
Randomised controlled clinical trials are fundamental in medicine to develop new effective drugs and new therapeutic regimens and are the strength of evidence-based medicine. These studies allow us to avoid the repetition of misleading experiences that have been reported in the past, where drugs or associations were utilised without compelling evidence and ultimately proven to be ineffective. In recent years, randomised clinical trials have been conducted and concluded for many rare diseases, including idiopathic pulmonary fibrosis. However, clinical trials do not always reflect the real-life scenario. Patients selected fo...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Harari, S., Caminati, A. Tags: Interstitial and orphan lung disease Reviews Source Type: research

Smoking and interstitial lung diseases
For many years has been well known that smoking could cause lung damage. Chronic obstructive pulmonary disease and lung cancer have been the two most common smoking-related lung diseases. In the recent years, attention has also focused on the role of smoking in the development of interstitial lung diseases (ILDs). Indeed, there are three diseases, namely respiratory bronchiolitis-associated ILD, desquamative interstitial pneumonia and pulmonary Langerhans cell histiocytosis, that are currently considered aetiologically linked to smoking and a few others which are more likely to develop in smokers. Here, we aim to focus on ...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Margaritopoulos, G. A., Vasarmidi, E., Jacob, J., Wells, A. U., Antoniou, K. M. Tags: Interstitial and orphan lung disease Reviews Source Type: research

Epidemiological studies in idiopathic pulmonary fibrosis: pitfalls in methodologies and data interpretation
Data on incidence, prevalence and mortality of idiopathic pulmonary fibrosis (IPF) are sparse and vary across studies. The true incidence and prevalence of the disease are unknown. In general, the overall prevalence and incidence reported in European and Asian countries are lower than those reported in American studies. In recent years, the epidemiological approach to IPF has been difficult for many reasons. First, the diagnostic criteria of the disease have changed over time. Secondly, the coding system used for IPF in administrative databases, the most common data source used to study this aspect of the disease, has been...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Caminati, A., Madotto, F., Cesana, G., Conti, S., Harari, S. Tags: Interstitial and orphan lung disease Reviews Source Type: research

ERS/ELS/ACCP 2013 international consensus conference nomenclature on inducible laryngeal obstructions
Individuals reporting episodes of breathing problems caused by re-occurring variable airflow obstructions in the larynx have been described in an increasing number of publications, with more than 40 different terms being used without consensus on definitions. This lack of an international consensus on nomenclature is a serious obstacle for the development of the area, as knowledge from different centres cannot be matched, pooled or readily utilised by others. Thus, an international Task Force has been created, led by the European Respiratory Society/European Laryngological Society/American College of Chest Physicians. This...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Christensen, P. M., Heimdal, J.-H., Christopher, K. L., Bucca, C., Cantarella, G., Friedrich, G., Halvorsen, T., Herth, F., Jung, H., Morris, M. J., Remacle, M., Rasmussen, N., Wilson, J. A., on behalf of the ERS/ELS/ACCP Task Force on Inducible Laryngeal Tags: Interstitial and orphan lung disease Reviews Source Type: research

Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a meta-analysis
In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with chronic bronchitis and chronic obstructive pulmonary disease (COPD), we have carried out a meta-analysis testing the available evidence that NAC treatment may be effective in preventing exacerbations of chronic bronchitis or COPD and evaluating whether there is a substantial difference between the responses induced by low (≤600 mg per day) and high (>600 mg per day) doses of NAC. The results of the present meta-analysis (13 studies, 4155 COPD patients, NAC n=1933; placebo or controls n=2222) showed that patient...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Cazzola, M., Calzetta, L., Page, C., Jardim, J., Chuchalin, A. G., Rogliani, P., Gabriella Matera, M. Tags: COPD and smoking Reviews Source Type: research

Environmental exposure to pesticides and respiratory health
In conclusion, further studies are needed to confirm whether there is a respiratory risk associated with environmental exposure to pesticides. (Source: European Respiratory Review)
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Mamane, A., Raherison, C., Tessier, J.-F., Baldi, I., Bouvier, G. Tags: COPD and smoking, Epidemiology, occupational and environmental lung disease, Asthma and allergy Reviews Source Type: research

National and regional asthma programmes in Europe
This review presents seven national asthma programmes to support the European Asthma Research and Innovation Partnership in developing strategies to reduce asthma mortality and morbidity across Europe. From published data it appears that in order to influence asthma care, national/regional asthma programmes are more effective than conventional treatment guidelines. An asthma programme should start with the universal commitments of stakeholders at all levels and the programme has to be endorsed by political and governmental bodies. When the national problems have been identified, the goals of the programme have to be clearl...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Selroos, O., Kupczyk, M., Kuna, P., Łacwik, P., Bousquet, J., Brennan, D., Palkonen, S., Contreras, J., FitzGerald, M., Hedlin, G., Johnston, S. L., Louis, R., Metcalf, L., Walker, S., Moreno-Galdo, A., Papadopoulos, N. G., Rosado-Pinto, J., Powell Tags: Asthma and allergy Reviews Source Type: research

Developments in the management and treatment of pulmonary embolism
Pulmonary embolism (PE) is a serious and costly disease for patients and healthcare systems. Guidelines emphasise the importance of differentiating between patients who are at high risk of mortality (those with shock and/or hypotension), who may be candidates for thrombolytic therapy or surgery, and those with less severe presentations. Recent clinical studies and guidelines have focused particularly on risk stratification of intermediate-risk patients. Although the use of thrombolysis has been investigated in these patients, anticoagulation remains the standard treatment approach. Individual risk stratification directs in...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Limbrey, R., Howard, L. Tags: Pulmonary vascular disease Reviews Source Type: research

Informal caregivers of patients with COPD: Home Sweet Home?
This article reviews the current knowledge about these informal caregivers of patients with COPD, the impact of COPD on their lives and their perception of the patient's health status. (Source: European Respiratory Review)
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Nakken, N., Janssen, D. J. A., van den Bogaart, E. H. A., Wouters, E. F. M., Franssen, F. M. E., Vercoulen, J. H., Spruit, M. A. Tags: COPD and smoking Reviews Source Type: research

The heterogeneity of lung macrophages in the susceptibility to disease
Alveolar macrophages are specialised resident phagocytes in the alveolus, constituting the first line of immune cellular defence in the lung. As the lung microenvironment is challenged and remodelled by inhaled pathogens and air particles, so is the alveolar macrophage pool altered by signals that maintain and/or replace its composition. The signals that induce the recruitment of circulating monocytes to the injured lung, as well as their distinct gene expression profile and susceptibility to epigenetic reprogramming by the local environment remain unclear. In this review, we summarise the unique characteristics of the alv...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Morales-Nebreda, L., Misharin, A. V., Perlman, H., Budinger, G. R. S. Tags: COPD and smoking Lung Science Conference Source Type: research

Macrophage adaptation in airway inflammatory resolution
Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the disease spectrum and are often difficult to treat. Most of the unmet medical need remains in this patient group. Airway macrophages are one of the first cell populations to encounter airborne pathogens and, in health, exist in a state of reduced responsiveness due to interactions with the respiratory epithelium and specific fac...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Kaur, M., Bell, T., Salek-Ardakani, S., Hussell, T. Tags: Lung biology and experimental studies, Respiratory infections and tuberculosis Lung Science Conference Source Type: research

Therapeutic strategies in pneumonia: going beyond antibiotics
Dysregulation of the innate immune system drives lung injury and its systemic sequelae due to breakdown of vascular barrier function, harmful hyperinflammation and microcirculatory failure, which contribute to the unfavourable outcome of patients with severe pneumonia. A variety of promising therapeutic targets have been identified and numerous innovative therapeutic approaches demonstrated to improve lung injury in experimental preclinical studies. However, at present specific preventive or curative strategies for the treatment of lung failure in pneumonia in addition to antibiotics are still missing. The aim of this mini...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Muller-Redetzky, H., Lienau, J., Suttorp, N., Witzenrath, M. Tags: Respiratory infections and tuberculosis Lung Science Conference Source Type: research

Should lung biopsies be performed in patients with severe asthma?
Asthma, and severe asthma, in particular, is increasingly recognised as a heterogeneous disease. Identifying these different phenotypes of asthma and assigning patients to phenotype-specific treatments is one of the current conundrums in respiratory medicine. Any diagnostic procedure in severe asthma (or any disease) should have two aims: 1) better understanding or identifying the diagnosis, and 2) providing information on the heterogeneity of asthma phenotypes to guide therapy with the objective of improving outcomes. Lung biopsies can target the large and small airways as well as the lung parenchyma. All compartments are...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Doberer, D., Trejo Bittar, H. E., Wenzel, S. E. Tags: Asthma and allergy Series Source Type: research

A rare case of diffuse pulmonary ossification
A 45 year-old male patient presented to our clinic with chronic dyspnoea on exertion. He had no cough, fever or weight loss. He smoked tobacco for 2 months 25 years ago and had no significant occupational exposure. He had a chest radiograph 20 years ago following an episode of bronchitis, which reportedly showed "calcification of the lungs". Chest auscultation revealed fine bibasilar crackles. He underwent a computed tomography (CT) scan of the chest, which showed diffuse calcified nodular lesions (figure  1a–c). Laboratory workup revealed normal calcium, phosphorus, vitamin D and parathyroid...
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Jambeih, R., Sawh, R. Tags: Interstitial and orphan lung disease Images in Respiratory Medicine Source Type: research

Inhalation challenge in the differential diagnosis of usual interstitial pneumonia
Establishing when a patient with usual interstitial pneumonia (UIP) is truly idiopathic is fundamental. In this sense, the paper recently published by Wuyts et al. [1], is an excellent review of the various diseases that may present with a histopathology consistent with UIP. (Source: European Respiratory Review)
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Authors: Munoz, X., Sanchez-Ortiz, M., Ojanguren, I., Cruz, M. J. Tags: Interstitial and orphan lung disease Correspondence Source Type: research

"Idiopathic inflammatory myopathies and the lung." Jean-Christophe Lega, Quitterie Reynaud, Alexandre Belot, Nicole Fabien, Isabelle Durieu and Vincent Cottin. Eur Respir Rev 2015; 24: 216-238.
(Source: European Respiratory Review)
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Tags: Author correction Source Type: research

"Long-term clinical and real-world experience with pirfenidone in the treatment of idiopathic pulmonary fibrosis." Vincent Cottin and Toby Maher. Eur Respir Rev 2015; 24: 58-64.
(Source: European Respiratory Review)
Source: European Respiratory Review - August 31, 2015 Category: Respiratory Medicine Tags: Author Correction Source Type: research

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Children with life threatening illness and infants born early, sick or with complex congenital conditions, now more than ever have a greater chance of surviving through childhood and adulthood. In part, this is due to improvements in respiratory therapies in neonatal and paediatric intensive care units. Ongoing morbidities mean that these children may require further periods of paediatric intensive care later in childhood. Therefore clinicians need access to a source that comprehensively covers aspects of ventilation available in both settings. (Source: Seminars in Fetal and Neonatal Medicine)
Source: Seminars in Fetal and Neonatal Medicine - August 31, 2015 Category: Perinatology & Neonatology Authors: Helen Chitty, Rachel Agbeko Tags: Book review Source Type: research