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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

The Equilibration of PCO2 in Pigs Is Independent of Lung Injury and Hemodynamics
Conclusions: The transition between PetCO2 equilibria after changes in respiratory rate might not be dependent on moderate lung injury or cardiac output but on the metabolic production or capacity of cO2 stores. Linear relationships previously found for lung-healthy patients and early prediction of PetCO2 equilibration could therefore also be used for the titration of respiratory rate on the PetCO2 for a wider range of pathologies by the physician or an automated ventilation system. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain–Containing Protein-2 Critically Regulates Influenza A Virus–Induced Pneumonia
Conclusions: These data support an important function of sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain–containing protein-2 in controlling influenza virus–induced pneumonia and viral replication. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain–containing protein-2 may be a novel therapeutic target for controlling the immune response against influenza influenza A virus infection. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Alda-1 Attenuates Lung Ischemia-Reperfusion Injury by Reducing 4-Hydroxy-2-Nonenal in Alveolar Epithelial Cells
Conclusions: Our study indicates that the accumulation of 4-hydroxy-2-nonenal plays an important role in lung ischemia-reperfusion injury. Alda-1 pretreatment can attenuate lung ischemia-reperfusion injury, possibly through the activation of aldehyde dehydrogenase-2, which in turn removes 4-hydroxy-2-nonenal in human pulmonary alveolar epithelial cells. Alda-1 pretreatment has clinical implications to protect lungs during cardiopulmonary bypass. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Lung Functional and Biologic Responses to Variable Ventilation in Experimental Pulmonary and Extrapulmonary Acute Respiratory Distress Syndrome
Conclusions: Variable ventilation improved lung function in both pulmonary acute respiratory distress syndrome and extrapulmonary acute respiratory distress syndrome. Variable ventilation led to more pronounced beneficial effects in biologic marker expressions in pulmonary acute respiratory distress syndrome compared with extrapulmonary acute respiratory distress syndrome but preserved E-cadherin in lung tissue only in extrapulmonary acute respiratory distress syndrome, thus suggesting lower damage to epithelial cells. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Serum Amyloid P Contained in Alveolar Fluid From Patients With Acute Respiratory Distress Syndrome Mediates the Inhibition of Monocyte Differentiation into Fibrocyte
Conclusions: The presence of fibrocytes in the lung during acute respiratory distress syndrome could result in a balance between higher ability of monocytes to differentiate into fibrocytes and the inhibitory effect of the alveolar environment, mainly dependent on serum amyloid P. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Laboratory Investigations Source Type: research

Changes in Whole-Body Oxygen Consumption and Skeletal Muscle Mitochondria During Linezolid-Induced Lactic Acidosis
Conclusions: Linezolid-induced lactic acidosis is associated with diminished global oxygen consumption and extraction. These changes reflect selective inhibition of mitochondrial protein synthesis (probably translation) with secondary mitonuclear imbalance. One novel aspect of linezolid toxicity that needs to be confirmed is blunting of reactive mitochondrial biogenesis and unfolded protein response. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Case Reports Source Type: research

Intracardiac Right-to-Left Shunt Impeding Liberation From Veno-Venous Extracorporeal Membrane Oxygenation: Two Case Studies
Conclusions: Veno-venous extracorporeal membrane oxygenation return flow generates a high-pressure jet that has potential to exert focal pressure upon the intra-atrial septum. In patients with potential for interatrial flow, this may lead to a right-to-left shunt, which becomes physiologically apparent only when sweep gas flow is ceased. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Online Case Reports Source Type: research

Age, PaO2/FIO2, and Plateau Pressure Score: A Proposal for a Simple Outcome Score in Patients With the Acute Respiratory Distress Syndrome*
Conclusions: A simple 9-point score based on the values of age, PaO2/FIO2 ratio, and plateau pressure calculated at 24 hours on protective ventilation after acute respiratory distress syndrome diagnosis could be used in real time for rating prognosis of acute respiratory distress syndrome patients with high probability. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Clinical Investigations Source Type: research

Impact of Initial Ventilatory Strategy in Hematological Patients With Acute Respiratory Failure: A Systematic Review and Meta-Analysis*
Conclusions: Noninvasive mechanical ventilation is associated with a lower risk of death in hematological patients with respiratory failure. Noninvasive mechanical ventilation failure may worsen the prognosis, mainly in less severe patients. (Source: Critical Care Medicine)
Source: Critical Care Medicine - June 18, 2016 Category: Emergency Medicine Tags: Review Article Source Type: research

Can we measure ‘Sensationalisim’ and ‘Spin’?
Two papers address these terms, more often seen in newsstands but unusual in a clinical epidemiology journal, of: ‘sensationalism’ and ‘spin’. Hoffman et al report on the development and validation of a method for automatically quantifying sensationalism and comparing this to relevance and scientific quality of news reports. The authors conclude that automated methods can evaluate news records faster, cheaper, and possibly better than humans. From a sample of 163,433 news records mentioning the Severe Acute Respiratory Syndrome (SARS) and H1N1 pandemics, the computer model agreed with human assessment of sensation...
Source: Journal of Clinical Epidemiology - June 18, 2016 Category: Epidemiology Authors: Peter Tugwell, J. André Knottnerus Tags: Editorial Source Type: research

Notes from the Field: Strongyloidiasis at a Long-Term-Care Facility for the Developmentally Disabled - Arizona, 2015.
Abstract Strongyloides stercoralis is an intestinal nematode endemic in the tropics and subtropics. Infection is usually acquired through skin contact with contaminated soil, or less commonly, from person to person through fecal contamination of the immediate environment. Infections are often asymptomatic, but can result in a pruritic rash, respiratory symptoms (e.g., cough or wheeze), and gastrointestinal symptoms (e.g., diarrhea and vomiting). Immunosuppressed persons can develop strongyloides hyperinfection syndrome, which can be fatal (1). In June 2015, the Pinal County Public Health Services District in Arizon...
Source: MMWR Morb Mortal Wkl... - June 18, 2016 Category: Epidemiology Authors: Jones JM, Hill C, Briggs G, Gray E, Handali S, McAuliffe I, Montgomery S, Komatsu K, Adams L Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Surgical Method, Postoperative Complications, and Gastrointestinal Motility of Thoraco-Laparoscopy 3-Field Esophagectomy in Treatment of Esophageal Cancer.
CONCLUSIONS Thoraco-laparoscopic esophagectomy was technically feasible and safe; it was associated with lower incidence of certain postoperative complications and had less effect on postoperative gastrointestinal motility. Skilled technique and cooperation could further shorten the operation time and might lead to better patient outcomes. PMID: 27310399 [PubMed - as supplied by publisher] (Source: Medical Science Monitor)
Source: Medical Science Monitor - June 18, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Effects of tiotropium + olodaterol versus tiotropium or placebo by COPD disease severity and previous treatment history in the OTEMTO® studies
As lung function declines rapidly in the early stages of chronic obstructive pulmonary disease (COPD), the effects of bronchodilators in patients with moderate disease and those who have not previously receive... (Source: Respiratory Research)
Source: Respiratory Research - June 18, 2016 Category: Respiratory Medicine Authors: Dave Singh, Mina Gaga, Olaf Schmidt, Leif Bjermer, Lars Grönke, Florian Voß and Gary T. Ferguson Source Type: research

Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)
It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is ... (Source: Intensive Care Medicine Experimental)
Source: Intensive Care Medicine Experimental - June 18, 2016 Category: Surgery Authors: Gary F. Nieman, Joshua Satalin, Penny Andrews, Nader M. Habashi and Louis A. Gatto Source Type: research

Aerosol concentration and particle size distributions in underground excavations of hard coal mine.
Authors: Skubacz K, Wojtecki Ł, Urban P Abstract Deposition of aerosols in the respiratory system depends inter alia on their size and the respiratory tract deposition is appreciable for nanometer-sized particles. This paper presents the results of measurements of size distributions of aerosols in the range of several nanometers up to about 20 µm in the underground mine excavations of an active hard coal mine. The study included practically all particles of a respirable fraction. The results showed that a high concentration of fine and ultrafine aerosols occurs in key underground workplaces especially during mini...
Source: International Journal of Occupational Safety and Ergonomics - June 18, 2016 Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research

Associations between brain white matter integrity and disease severity in obstructive sleep apnea
This study examines associations between an index of tissue integrity, magnetization transfer (MT) ratio values (which show MT between free and proton pools associated with tissue membranes and macromolecules), and disease severity (apnea‐hypopnea index [AHI]) in OSA subjects. We collected whole‐brain MT imaging data from 19 newly diagnosed, treatment‐naïve OSA subjects (50.4 ± 8.6 years of age, 13 males, AHI 39.7 ± 24.3 events/hr], using a 3.0‐Tesla MRI scanner. With these data, whole‐brain MT ratio maps were calculated, normalized to common space, smoothed, and correlated with AHI scores by using partial cor...
Source: Journal of Neuroscience Research - June 18, 2016 Category: Neuroscience Authors: Sudhakar Tummala, Bhaswati Roy, Bumhee Park, Daniel W. Kang, Mary A. Woo, Ronald M. Harper, Rajesh Kumar Tags: Research Article Source Type: research

Continuous interscalene brachial plexus nerve block prolongs unilateral diaphragmatic dysfunction
Conclusion Over infusion, continuous ISB did not significantly prolong unilateral phrenic paresis and demonstrated a limited pulmonary impact. (Source: Anaesthesia, Critical Care and Pain Medicine)
Source: Anaesthesia, Critical Care and Pain Medicine - June 18, 2016 Category: Anesthesiology Source Type: research

Preface: Cystic Fibrosis in Children and Adults
(Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - June 18, 2016 Category: Respiratory Medicine Authors: T J David Source Type: research

Multiple prevalent fractures in relation to macroscopic bone architecture in patients with cystic fibrosis
The relative risk for bone fractures in patients with cystic fibrosis (CF) and its relationship to macroscopic bone architecture assessed by pQCT and DXA are incompletely defined. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 18, 2016 Category: Respiratory Medicine Authors: Mirjam Stahl, Christian Holfelder, Carolin Kneppo, Meinhard Kieser, Christian Kasperk, Eckhard Schoenau, Olaf Sommerburg, Burkhard Tönshoff Tags: Original Article Source Type: research

CF end point commentary
With the development of new, potentially disease-modifying treatments for patients with cystic fibrosis (CF) in recent years, the review article by Stanojevic and Ratjen in this edition of the Journal of Cystic Fibrosis is timely [1]. The authors point out that over the course of time, as more and more effective therapies to treat the pulmonary manifestations of CF have been available, it is increasingly difficult to design, conduct, and interpret studies using the lung-function-based, forced expiratory volume in 1second, (FEV1) as a primary end point in clinical studies. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 18, 2016 Category: Respiratory Medicine Authors: Anthony G. Durmowicz Source Type: research

Iron deficiency anemia as a risk factor in childhood asthma
Conclusions Iron deficiency anemia may be considered as an indirect risk factor for childhood asthma also iron deficiency anemia may have a negative effect on spirometry of asthmatic children. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - June 18, 2016 Category: Respiratory Medicine Source Type: research

Clinical presentations and outcome of severe community-acquired pneumonia
Conclusion SCAP occurs more frequently in those with comorbidities. The most frequent isolated causative organism of SCAP is S. pneumoniae, Influenza H1N1 and S. aureus. SCAP is associated with significant mortality, early recognition and prompt treatment may improve outcome. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - June 18, 2016 Category: Respiratory Medicine Source Type: research

Safety and outcome of medical thoracoscopy as diagnostic tool for pleural and pulmonary diseases
Conclusion Medical thoracoscopy is safe and effective for the diagnosis of benign and malignant pleural disease and pulmonary nodules. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - June 18, 2016 Category: Respiratory Medicine Source Type: research

Sildenafil citrate therapy for secondary pulmonary arterial hypertension due to chronic obstructive lung disease
Conclusion Sildenafil improves exercise capacity, and hemodynamic in patients with symptomatic pulmonary arterial hypertension. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - June 18, 2016 Category: Respiratory Medicine Source Type: research

A mucoactive drug carbocisteine ameliorates steroid resistance in rat COPD model
Publication date: Available online 18 June 2016 Source:Pulmonary Pharmacology & Therapeutics Author(s): Yun Song, Ping Yu, Juan-Juan Lu, Hao-Zhong Lu, Liang Zhu, Zhi-Hua Yu, Hong-Zhuan Chen, Yong-Yao Cui Steroid insensitivity has been commonly found in chronic obstructive pulmonary disease (COPD) patients, which is mediated by the reduction of histone deacetylase (HDAC) 2. Here we aimed to establish a steroid resistant model on experimental COPD rats and evaluate the effect of carbocisteine (S-CMC), a mucoactive drug. Exposure to cigarette smoke (CS) caused marked pathological features of COPD which are i...
Source: Pulmonary Pharmacology and Therapeutics - June 18, 2016 Category: Respiratory Medicine Source Type: research

Activation of cannabinoid CB1 receptors suppresses the ROS-induced hypersensitivity of rat vagal lung C-fiber afferents
Conclusions Our results suggest that activation of CB1 receptors may suppress the ROS-mediated VLCF hypersensitivity through a mechanism that is at least partly distinct from the function of TRPA1 and P2X receptors. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 18, 2016 Category: Respiratory Medicine Source Type: research

A critical postnatal period of heightened vulnerability to lipopolysaccharide
Publication date: Available online 18 June 2016 Source:Respiratory Physiology & Neurobiology Author(s): Kyle S. Rourke, Catherine A. Mayer, Peter M. MacFarlane Evidence of respiratory abnormalities and vulnerability to infection during a critical period of development have been implicated in Sudden Infant Death Syndrome (SIDS). Here we investigated whether the acute hypoxic ventilatory response (HVR) exhibits a heightened vulnerability to the endotoxin lipopolysaccharide (LPS) during a critical period of development. The acute HVR was measured 2hrs after an i.p. injection of saline or LPS (0.1mg/kg) at various...
Source: Respiratory Physiology and Neurobiology - June 18, 2016 Category: Respiratory Medicine Source Type: research

Hydroxyethyl starch versus saline for resuscitation of patients in intensive care: long-term outcomes and cost-effectiveness analysis of a cohort from CHEST
Publication date: Available online 17 June 2016 Source:The Lancet Respiratory Medicine Author(s): Colman Taylor, Kelly Thompson, Simon Finfer, Alisa Higgins, Stephen Jan, Qiang Li, Bette Liu, John Myburgh Background Hydroxyethyl starch for fluid resuscitation in critically ill patients is not associated with improved short-term patient-centred outcomes compared with crystalloid fluid solutions. However, its effect on longer term health economic outcomes has not been reported. Methods We did a prespecified cost-effectiveness analysis of a cohort of patients from New South Wales enrolled in the Crystalloid versus ...
Source: The Lancet Respiratory Medicine - June 18, 2016 Category: Respiratory Medicine Source Type: research

The cost of shock resuscitation treatment decisions
Publication date: Available online 17 June 2016 Source:The Lancet Respiratory Medicine Author(s): Michael R Pinsky (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 18, 2016 Category: Respiratory Medicine Source Type: research

Cough up
Publication date: 18 June 2016 Source:New Scientist, Volume 230, Issue 3078 Have any viruses that cause respiratory tract infections evolved methods of promoting sneezing or coughing… (Source: New Scientist)
Source: New Scientist - June 18, 2016 Category: Science Source Type: research

Longitudinal Follow-up of Chronic Pulmonary Manifestations in Esophageal Atresia: A Clinical Algorithm and Review of the Literature
In the past decades improved surgical techniques and better neonatal supportive care have resulted in reduced mortality of patients with esophageal atresia (EA), with or without tracheoesophageal fistula, and in increased prevalence of long-term complications, especially respiratory manifestations. This integrative review describes the techniques currently used in the pediatric clinical practice for assessing EA-related respiratory disease. We also present a novel algorithm for the evaluation and surveillance of lung disease in EA. (Source: Pediatrics and Neonatology)
Source: Pediatrics and Neonatology - June 18, 2016 Category: Perinatology & Neonatology Authors: Virginia Mirra, Marco Maglione, Laida L. Di Micco, Silvia Montella, Francesca Santamaria Tags: Review article Source Type: research

Molecular and epidemiological study of human parechovirus infections in Taiwan, 2007–2012
Conclusion This study showed that HPeVs have been endemic in Taiwan for some years despite a low positive rate. The detection tests of HPeVs are needed to correct a diagnostic deficit in the surveillance system. The epidemiological and genetic information obtained from the present study would contribute to the understanding of the etiology and epidemiology of HPeVs. (Source: Journal of Microbiology, Immunology and Infection)
Source: Journal of Microbiology, Immunology and Infection - June 18, 2016 Category: Microbiology Source Type: research

Cardiac and Respiratory Disease in Aged Horses
Respiratory and cardiac diseases are common in older horses. Advancing age is a specific risk factor for cardiac murmurs and these are more likely in males and small horses. Airway inflammation is the most common respiratory diagnosis. Recurrent airway obstruction can lead to irreversible structural change and bronchiectasis; with chronic hypoxia, right heart dysfunction and failure can develop. Valvular heart disease most often affects the aortic and/or the mitral valve. Management of comorbidity is an essential element of the therapeutic approach to cardiac and respiratory disease in older equids. (Source: Veterinary Cli...
Source: Veterinary Clinics of North America: Equine Practice - June 18, 2016 Category: Veterinary Research Authors: Celia M. Marr Source Type: research

Paraneoplastic pemphigus as a first sign of metastatic retroperitoneal inflammatory myofibroblastic tumor: 18F-FDG PET/CT findings
Publication date: July–August 2016 Source:Revista Española de Medicina Nuclear e Imagen Molecular (English Edition), Volume 35, Issue 4 Author(s): V.S. Dhull, A. Passah, N. Rana, S. Arora, S. Mallick, R. Kumar A 30-year-old female presented with a 3-month history of erosive stomatitis and bullous lesions, along with recurrent episodes of abdominal pain. She was found to have a retroperitoneal lump in left lumbar region. Skin biopsy revealed bullous disorder. CT guided biopsy of the retroperitoneal mass was suggestive of inflammatory myofibroblastic tumor (IMT). She was started on oral steroids and supportive car...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - June 18, 2016 Category: Nuclear Medicine Source Type: research

Physiological correlates to spontaneous physical activity variability in obese patients with already treated sleep apnea syndrome
Conclusions In severe obese patients with OSA, exercise capacity, ventilatory requirement, and dyspnea perception were main physiological components of physical activity. These results emphasize the need to consider specific training interventions that increase ability to perform intense physical activity in obese OSA. (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 18, 2016 Category: Respiratory Medicine Source Type: research

Physiological Response to Social Evaluative Threat in Adolescents with Autism Spectrum Disorder.
Abstract The Trier Social Stress Test (TSST) was employed to study response to social evaluative threat in male adolescents with Autism Spectrum Disorder (ASD, n = 21) and typical development (n = 13). Participants wore a mobile electrocardiogram to collect heart rate data. There were significant group effects on respiratory sinus arrhythmia (RSA), a measure of parasympathetic nervous system function, with lower values in ASD (F = 4.97). Bivariate correlations also showed a significant relationship between parent reports of social problems and RSA response to the TSST (r = -0.586). These findings suggest th...
Source: Journal of Autism and Developmental Disorders - June 18, 2016 Category: Psychiatry Authors: Edmiston EK, Jones RM, Corbett BA Tags: J Autism Dev Disord Source Type: research

Physiological correlates to spontaneous physical activity variability in obese patients with already treated sleep apnea syndrome.
CONCLUSIONS: In severe obese patients with OSA, exercise capacity, ventilatory requirement, and dyspnea perception were main physiological components of physical activity. These results emphasize the need to consider specific training interventions that increase ability to perform intense physical activity in obese OSA. PMID: 27318994 [PubMed - as supplied by publisher] (Source: Sleep and Breathing)
Source: Sleep and Breathing - June 18, 2016 Category: Sleep Medicine Authors: Vivodtzev I, Mendelson M, Croteau M, Gorain S, Wuyam B, Tamisier R, Lévy P, Maltais F, Pépin JL Tags: Sleep Breath Source Type: research

Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question.
Abstract Toll-like receptor (TLR) 2 is expressed on immune cells and respiratory epithelial cells lining the lung. TLR2 is not critical for protection during acute Mycobacterium tuberculosis (Mtb) infection but it has a significant multi-faceted role in containing chronic infection. This review highlights the contribution of TLR2 to host protection, immune evasion by Mtb and immune regulation during chronic Mtb infection. The TLR2-triggered pro-inflammatory cytokines initiate protective mechanisms and limit Mtb replication while the immune evasion pathways counterattack anti-bacterial effector mechanisms. The immun...
Source: Current Opinion in Immunology - June 18, 2016 Category: Allergy & Immunology Authors: Gopalakrishnan A, Salgame P Tags: Curr Opin Immunol Source Type: research

Percutaneous Bullectomy in Conjunction with Endobronchial Valve Placement as an Alternative to Surgical Management of Giant Bullae
We present the first reported case of the treatment and management of a giant bulla using percutaneous bullectomy and endobronchial valve placement. A 74-year-old woman with chronic obstructive pulmonary disease and a known large bulla in the left chest presented to the emergency department with acute-onset confusion after a traumatic fall. She was subsequently diagnosed with an intracranial hemorrhage in the distribution of the right basal ganglia. Chest imaging revealed a giant apical bulla occupying 80% of the left hemithorax. In addition, there was midline shift away from the affected side associated with volume loss i...
Source: Respiration - June 17, 2016 Category: Respiratory Medicine Source Type: research

Association of daytime sleepiness with obstructive sleep apnoea and comorbidities varies by sleepiness definition in a population cohort of men
ConclusionSleepiness not necessarily leading to dozing, but not ESS ≥ 11, was related to sleep disordered breathing. Clinicians should be alert to (1) differing perspectives of sleepiness for investigation and treatment of OSA, and (2) the presence of depression and nocturia in men presenting with significant Epworth sleepiness regardless of the presence of OSA. (Source: Respirology)
Source: Respirology - June 17, 2016 Category: Respiratory Medicine Authors: Robert J. Adams, Sarah L. Appleton, Andrew Vakulin, Carol Lang, Sean A. Martin, Anne W. Taylor, R. Doug McEvoy, Nick A. Antic, Peter G. Catcheside, Gary A. Wittert Tags: Original Article Source Type: research

Fibrotic gene expression coexists with alveolar proteinosis in early indium lung.
In this study, we constructed a mouse model of indium lung disease and analyzed gene expression in response to indium exposure. Indium oxide (In2O3, 10 mg/kg, primary particle size <100 nm) was administered intratracheally to C57BL/6 mice (male, 8 weeks of age) twice a week for 8 weeks. Four weeks after the final instillation, histopathological analysis exhibited periodic acid-Schiff positive material in the alveoli, characteristic of PAP. Comprehensive gene expression analysis by RNA-Seq, however, revealed expression of fibrosis-related genes, such as surfactant associated protein D, surfactant associated protein...
Source: Inhalation Toxicology - June 17, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research

Development of an inhalation unit risk factor for ethylene dichloride.
Authors: Myers JL Abstract The Texas Commission on Environmental Quality (TCEQ) conducts up-to-date carcinogenic assessments for chemicals emitted in Texas. An inhalation unit risk factor (URF) was developed for ethylene dichloride (EDC, CAS 107-06-2) based on tumorigenicity results observed in a 2-year animal inhalation study conducted by Nagano et al. More specifically, the incidence of combined mammary gland tumors (adenomas, fibroadenomas, adenocarcinomas) in female rats demonstrated a statistically significant dose-response relationship, was amenable to benchmark concentration (BMC) modeling, was ultimately de...
Source: Inhalation Toxicology - June 17, 2016 Category: Respiratory Medicine Tags: Inhal Toxicol Source Type: research