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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Slow and Deep Respiration Suppresses Steady-State Sympathetic Nerve Activity in Patients with Chronic Heart Failure: From Modeling to Clinical Application.
Abstract Influences of slow and deep respiration on steady-state sympathetic nerve activity remain controversial in humans and could vary depending on disease conditions and basal sympathetic nerve activity. To elucidate the respiratory modulation of steady-state sympathetic nerve activity, we modeled the dynamic nature of the relationship between lung inflation and muscle sympathetic nerve activity (MSNA) in 11 heart failure patients with exaggerated sympathetic outflow at rest. An autoregressive exogenous input model was utilized to simulate entire responses of MSNA to variable respiratory patterns. In another 18...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 15, 2014 Category: Physiology Authors: Harada D, Asanoi H, Takagawa J, Ishise H, Ueno H, Oda Y, Goso Y, Joho S, Inoue H Tags: Am J Physiol Heart Circ Physiol Source Type: research

Sleep Disordered Breathing and Chronic Respiratory Failure in Patients with Chronic Pain on Long Term Opioid Therapy
Conclusions:Patients on long-term opioids frequently have severe SDB, which in part is central in origin. PVT was markedly impaired. Half of the patients studied have evidence of chronic ventilatory failure.Commentary:A commentary on this article appears in this issue on page 853.Citation:Rose AR, Catcheside PG, McEvoy RD, Paul D, Kapur D, Peak E, Vakulin A, Antic NA. Sleep disordered breathing and chronic respiratory failure in patients with chronic pain on long term opioid therapy. J Clin Sleep Med 2014;10(8):847-852. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 14, 2014 Category: Sleep Medicine Source Type: research

A Novel Adaptive Servoventilation (ASVAuto) for the Treatment of Central Sleep Apnea Associated with Chronic Use of Opioids
Conclusions:The ASVAuto was significantly more effective than bilevel-ST for the treatment of CSA associated with chronic opioid use.Citation:Cao M, Cardell CY, Willes L, Mendoza J, Benjafield A, Kushida C. A novel adaptive servoventilation (ASVAuto) for the treatment of central sleep apnea associated with chronic use of opioids. J Clin Sleep Med 2014;10(8):855-861. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 14, 2014 Category: Sleep Medicine Source Type: research

Do Respiratory Cycle-Related EEG Changes or Arousals from Sleep Predict Neurobehavioral Deficits and Response to Adenotonsillectomy in Children?
Conclusion:Sleep fragmentation, as reflected by standard arousals or by RCREC, appears unlikely to explain neurobehavioral morbidity among children who undergo adenotonsillectomy.Clinical Trial Registration:ClinicalTrials.gov, ID: NCT00233194Citation:Chervin RD, Garetz SL, Ruzicka DL, Hodges EK, Giordani BJ, Dillon JE, Felt BT, Hoban TF, Guire KE, O'Brien LM, Burns JW. Do respiratory cycle-related EEG changes or arousals from sleep predict neurobehavioral deficits and response to adenotonsillectomy in children?. J Clin Sleep Med 2014;10(8):903-911. (Source: Journal of Clinical Sleep Medicine : JCSM)
Source: Journal of Clinical Sleep Medicine : JCSM - August 14, 2014 Category: Sleep Medicine Source Type: research

Twin Faces! Vitamin E and Respiratory and Atopic Diseases
This study aims to determine association of vitamin E isoforms (α- and γ-tocopherol) with wheeze and atopy. (Source: Annals of Epidemiology)
Source: Annals of Epidemiology - August 14, 2014 Category: Epidemiology Authors: Sreenivas Phanikumar Veeranki, Yan Cao, Shimin Zheng Tags: Abstracts Source Type: research

Manifold learning based ECG‐free free‐breathing cardiac CINE MRI
ConclusionAccurate respiratory and cardiac navigator signals can be estimated using the proposed framework from the acquired data itself, resulting in retrospective self‐gated CINE reconstruction with high spatial and temporal quality. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - August 14, 2014 Category: Radiology Authors: Muhammad Usman, David Atkinson, Christoph Kolbitsch, Tobias Schaeffter, Claudia Prieto Tags: Technical Note Source Type: research

Sequential infusion of donor derived dendritic cells with donor lymphocyte infusion for relapsed hematologic cancers after allogeneic hematopoietic stem cell transplantation
Conclusion: Sequential infusion of donor derived DC with DLI is feasible in patients with relapsed hematologic cancers after allogeneic HSCT. Future studies may consider donor DC preloaded with tumor antigens to investigate whether DC infusion could augment the GVL effect. (Source: American Journal of Hematology)
Source: American Journal of Hematology - August 14, 2014 Category: Hematology Authors: Vincent T. Ho, Haesook T. Kim, Grace Kao, Corey Cutler, James Levine, Jacalyn Rosenblatt, Robin Joyce, Joseph H. Antin, Robert J. Soiffer, Jerome Ritz, David Avigan, Edwin P. Alyea Tags: Research Article Source Type: research

Panax ginseng therapy for chronic obstructive pulmonary disease: a clinical trial protocol and pilot study
Conclusions: Participant recruitment, study design, data collection and outcome measurement have been tested in a pilot trial. A full-scale trial is warranted. (Source: Chinese Medicine)
Source: Chinese Medicine - August 14, 2014 Category: Complementary Medicine Authors: Lei WuAnthony ZhangYuan DiJohannah ShergisYuanbin ChenXinfeng GuoZehuai WenFrancis ThienChristopher WorsnopLin LinCharlie Xue Source Type: research

Australian Idiopathic Pulmonary Fibrosis Registry: Vital lessons from a national prospective collaborative project
There is little Australian epidemiologic data on idiopathic pulmonary fibrosis (IPF), a relatively uncommon but devastating disease. The vast geographic distances in Australia have been a major impediment for collaborative research into IPF. A collaborative national effort, the Australian IPF Registry, has been formed, launched and is recruiting successfully (n = 359, January 2014). Our experience provides unique insights for others wishing to set up IPF registries and in time for a global IPF registry. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Yuben Moodley, Nicole Goh, Ian Glaspole, Sacha Macansh, E Haydn Walters, Sally Chapman, Peter Hopkins, Paul N Reynolds, Christopher Zappala, Wendy Cooper, Annabelle Mahar, Samantha Ellis, Samuel McCormack, William Darbishire, Richard Wood‐Baker, Tamera Tags: Scientific Letter Source Type: research

Characteristics of patients with yellow nail syndrome and pleural effusion
Abstract Yellow nail syndrome (YNS) can be associated with a pleural effusion (PE) but the characteristics of these patients are not well defined. We performed a systematic review across four electronic databases for studies reporting clinical findings, PE characteristics, and most effective treatment of YNS. Case descriptions and retrospective studies were included, unrestricted by year of publication. We reviewed 112 studies (150 patients), spanning a period of nearly 50 years. The male/female ratio was 1.2/1. The median age was 60 years (range: 0–88). Seventy‐eight percent were between 41–80 years old. All cases h...
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Luis Valdés, John T. Huggins, Francisco Gude, Lucía Ferreiro, José M. Álvarez‐Dobaño, Antonio Golpe, María E. Toubes, Francisco J. González‐Barcala, Esther San José, Steven A. Sahn Tags: Systematic Review & Meta‐Analysis Source Type: research

Intratracheal co‐administration of antioxidants and ceftriaxone reduces pulmonary injury and mortality rate in an experimental model of sepsis
ConclusionsCeftriaxone plus intratracheal co‐administration of antioxidants provides better protection, by decreasing pulmonary oxidative stress, limiting histophatological alterations and improving survival. Antioxidants should be explored as a co‐adjuvant in the treatment of severe lung injury. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Andre M. Galvão, Marcela S.O. Wanderley, Roberto A. Silva, Carlos A.M. Filho, Mário R. Melo‐Junior, Luciano A. Silva, Emílio L. Streck, Armele F. Dornelas de Andrade, Maria B. Souza Maia, Celia M.M. Barbosa de Castro Tags: Original Article Source Type: research

Bronchoscopic interventions for chronic obstructive pulmonary disease
Abstract Over the past decade, several non‐surgical and minimally invasive bronchoscopic lung volume reduction (BLVR) techniques have been developed to treat patients with severe chronic obstructive pulmonary disease (COPD). BLVR can be significantly efficacious, suitable for a broad cohort of patients, and associated with a solid safety profile at a reasonable expense. The introduction of BLVR is also expected to accelerate the further development of interventional pulmonology worldwide. Recently, results from clinical studies on BLVR techniques have been published, providing valuable information about the procedure's i...
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Masamichi Mineshita, Dirk‐Jan Slebos Tags: Invited Review Series: Update in Interventional Pulmonology Source Type: research

Level of adherence to the GOLD strategy document for management of patients admitted to hospital with an acute exacerbation of COPD
ConclusionsHealth professionals in the respiratory team had better adherence to GOLD as compared to health professionals in other teams. Nonetheless, pharmacological interventions were both appropriately prescribed and also over‐prescribed, whereas non‐pharmacological interventions were used rarely, suggesting a need for practice review in these areas. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Clarice Y. Tang, Nicholas F. Taylor, Christine F. McDonald, Felicity C. Blackstock Tags: Original Article Source Type: research

The relationships among dyspnoea, health‐related quality of life and psychological factors in sarcoidosis
ConclusionDyspnoea is common in sarcoidosis and is associated with worse HRQL irrespective of baseline pulmonary function. Hyperventilation appears to be a factor contributing to dyspnoea and the Nijmegen questionnaire may be helpful in assessing dyspnoea and hyperventilation in sarcoidosis patients. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Sally Boer, John Kolbe, Margaret L. Wilsher Tags: Original Article Source Type: research

Clinical COPD Questionnaire in patients with chronic respiratory disease
ConclusionsThe CCQ is responsive to pulmonary rehabilitation in chronic respiratory disease patients, with an MID estimated at −0.4 at the individual level. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Jane L. Canavan, Deniz Dilaver, Amy L. Clark, Sarah E. Jones, Claire M. Nolan, Samantha S. C. Kon, William D.‐C. Man Tags: Original Article Source Type: research

A commercially available preparation of Staphylococcus aureus bio‐products potently inhibits tumour growth in a murine model of mesothelioma
ConclusionsThis proof‐of‐principle study demonstrates promising antitumoural activity of a commercially available compound of S. aureus bio‐products against mesothelioma. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Sally M. Lansley, Julius F. Varano della Vergiliana, Amanda L. Cleaver, Shaohua H. Ren, Amanda Segal, Ming Yan Xu, Y.C. Gary Lee Tags: Original Article Source Type: research

Correcting for the bias caused by exposure measurement error in epidemiological studies
Abstract An important goal of many epidemiological studies is to estimate the magnitude of association between an exposure and an outcome. Exposure measurement error causes bias in such estimates of association and can be substantial. In this article, we describe the problem of exposure measurement error and its effects. We show how a simple hand calculation, in conjunction with validation study data and a calibration equation, can be used to correct estimates for the bias caused by exposure measurement error. Correcting estimates of association for measurement error helps researchers appropriately assess effect size. (Source: Respirology)
Source: Respirology - August 14, 2014 Category: Respiratory Medicine Authors: Michael T. Fahey, Andrew B. Forbes, Alison M. Hodge Tags: Invited Review Series: Modern Statistical Methods in Respiratory Medicine Source Type: research

A comparative analysis of Pancoast tumour resection performed via video-assisted thoracic surgery versus standard open approaches
CONCLUSIONS In the management of Pancoast tumours, a thoracoscopic approach is safe and may be an effective adjunct to standard surgical resection in selected cases. Such an approach enabled surgeons to explore the pleural cavity and avoid exploratory thoracotomy in cases of unexpected pleural involvement. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - August 14, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Caronia, F. P., Fiorelli, A., Ruffini, E., Nicolosi, M., Santini, M., Lo Monte, A. I. Tags: Mediastinum, Education, Chest wall Thoracic Source Type: research

Comparative evaluation of high-flow nasal cannula and conventional oxygen therapy in paediatric cardiac surgical patients: a randomized controlled trial
CONCLUSIONS HFNC had no impact on PaCO2 values. The use of HFNC appeared to be safe and improved PaO2 in paediatric cardiac surgical patients. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - August 14, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Testa, G., Iodice, F., Ricci, Z., Vitale, V., De Razza, F., Haiberger, R., Iacoella, C., Conti, G., Cogo, P. Tags: Anesthesia, Great vessels, Mechanical Circulatory Assistance Congenital Source Type: research

Clinical effects and safety of different strategies for administering intravenous diuretics in acutely decompensated heart failure: a randomised clinical trial
Conclusions In patients with ADHF attending the ED, boluses of furosemide have a smaller diuretic effect but provide similar clinical relief, similar preservation of renal function, and a lower incidence of hypokalaemia than continuous infusion. Trial registration number This randomised trial was registered in the European Clinical Trial Database (EudraCT) with the reference number 2008-004488-20. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Llorens, P., Miro, O., Herrero, P., Martin-Sanchez, F. J., Jacob, J., Valero, A., Alonso, H., Perez-Dura, M. J., Noval, A., Gil-Roman, J. J., Zapater, P., Llanos, L., Gil, V., Perello, R. Tags: Drugs: cardiovascular system, Hypertension Original article Source Type: research

Motion artefact in multidetector CT in a child with severe chest injury resembling serious pathology
A 14-year-old boy was presented to the emergency department with dyspnoea and chest pain after severe chest injury due to a fall from a high tree. Sagittal reconstruction of multidetector computed tomography (MDCT) shows motion artefact in the manubrium of the sternum resembling severe fracture (figures 1). Lateral X-ray of the sternum (figures 2) excluded fracture and confirmed the diagnosis of motion artefact. Chest traumas are a significant cause of mortality and morbidity, especially in the younger population. MDCT is the most important imaging method in this field. Its advantages include high-speed and geometric resol...
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Artul, S., Yamini, A. Tags: Pain (neurology), Ethics, Trauma Images in emergency medicine Source Type: research

Prehospital use in emergency patients of a laryngeal mask airway by ambulance paramedics is a safe and effective alternative for endotracheal intubation
Conclusions Ensuring ventilation support by using LMA-S by paramedics in prehospital emergency practice is safe and effective. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Bosch, J., de Nooij, J., de Visser, M., Cannegieter, S. C., Terpstra, N. J., Heringhaus, C., Burggraaf, J. Tags: Open access, Resuscitation Prehospital care Source Type: research

Pre-hospital non-invasive ventilation for acute respiratory failure: a systematic review and network meta analysis
Conclusion Pre-hospital CPAP can reduce mortality and intubation rates compared to standard care, while the effectiveness of pre-hospital BiPAP is uncertain. Comparison of mortality for interventions versus standard care from the primary trials (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Goodacre, S. Tags: DAY ONE: FREE PAPERS: SEMINAR ROOMS 1[amp ]2, 14:30-16:00 Source Type: research

Pre-hospital continuous positive aireway pressure (cpap) for acute respiratory failure: an economic analysis
Conclusion The cost-effectiveness of pre-hospital CPAP is uncertain and current evidence is insufficient to support widespread implementation. The immediate research priority is to estimate the incidence of patients eligible for pre-hospital CPAP. This appears to be the key determinant of the cost-effectiveness of a future trial and of pre-hospital CPAP itself. Model structure (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Goodacre, S., Thokala, P. Tags: Resuscitation DAY TWO: FOUR TOP SCORING CEM ABSTRACTS: ALUMNI AUDITORIUM 14:30-15:30 Source Type: research

The long and winding road: do patients deteriorate during long ambulance journeys to hospital
Conclusion Our findings suggest that adult patients living further from hospital are not more unwell on pick-up, they are not deteriorating en-route, and longer journeys to hospital do not necessarily lead to patients coming to harm. However, we did not explore any relationship to later mortality/morbidity. We appeal to colleagues in those areas of the UK with electronic ambulance records linked to hospital records to repeat this work with a much larger sample and wider range of end-points, in order to provide a definitive answer to this important question. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Thorp, V., Kang, S., Dykes, L. Tags: DAY THREE: FREE PAPERS: SEMINAR ROOMS 1[amp ]2, 10:00-11:30 Source Type: research

The transition to expert: a qualitative study exploring clinical decision making for children under five attending the emergency department with minor respiratory conditions
Conclusion This research will interest educators and trainers operating in emergency paediatric settings. The emergence of 'informal learning', its acquisition and role in clinical decision making has implications in the development of training programmes for clinicians working in emergency paediatrics. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - August 14, 2014 Category: Emergency Medicine Authors: Bowen, L., Purdy, S., Lyttle, M. D., Heawood, A. Tags: TB and other respiratory infections, Child health, Infant health DAY THREE: FREE PAPERS: SEMINAR ROOMS 1[amp ]2, 10:00-11:30 Source Type: research

Upcoming events of interest
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 14, 2014 Category: Respiratory Medicine Tags: Upcoming Events Source Type: research

Adjuvant-dependent regulation of interleukin-17 expressing ¿¿ T cells and inhibition of Th2 responses in allergic airways disease
Conclusions: Thus, the conditions of antigen sensitization influence the profile of cells that produce IL-17, the balance of which may then modulate the airway inflammatory responses, including AHR. The possibility for IL-17-?? T cells to reduce AHR and robust eosinophilic inflammation provides evidence that therapeutic approaches focused on stimulating and increasing airway IL-17-?? T cells may be an effective alternative in treating steroid resistant, severe asthma. (Source: Respiratory Research)
Source: Respiratory Research - August 14, 2014 Category: Respiratory Medicine Authors: Emily NakadaJichuan ShanMargaret KinyanjuiElizabeth Fixman Source Type: research

Transport and deposition of pharmaceutical Particles in three commercial spacer-MDI Combinations
Respiratory drug delivery has been under the research spotlight for the past few decades, mainly due to the high incidence of pulmonary diseases and the fact that this type of delivery offers the highest efficiency for treatment. Despite its invaluable benefits, there are some major drawbacks to respiratory drug delivery, the most important of which being poor delivery efficiency and relatively high drug deposition in undesirable regions, such as the mouth cavity. One way to improve the efficiency of respiratory drug delivery with metered-dose inhalers is placing a respiratory spacer between the inhaler exit and the mouth....
Source: Computers in Biology and Medicine - August 14, 2014 Category: Bioinformatics Authors: A. Yazdani, M. Normandie, M. Yousefi, M.S. Saidi, G. Ahmadi Source Type: research

Effects of small airway dysfunction on the clinical expression of asthma: A focus on asthma symptoms and bronchial hyperresponsiveness
ConclusionSmall and large airway dysfunction poorly associate with asthma symptoms in our patients. However, deteriorations in small airway dysfunction are strongly related to an increase in dyspnea during bronchial provocation with methacholine. Small airway dysfunction contributes also independently to the clinical expression of asthma, as reflected by the severity of BHR.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - August 14, 2014 Category: Allergy & Immunology Authors: Erica Wiel, Dirkje S. Postma, Thys Molen, Lieke Schiphof‐Godart, Nick H.T. ten Hacken, Maarten den Berge Tags: Original Article: Airway Diseases Source Type: research

Profilin as a severe food allergen in allergic patients overexposed to grass pollen
ConclusionProfilins are complete food allergens in food‐allergic patient populations that are exposed to high levels of grass pollen. This type of patient constitutes an optimal model to understand the link between respiratory and food allergies. The nature of the observed reactions, and the low level of allergen eliciting the reactions, suggest that intake through the oral mucosa might constitute a relevant route of exposure to food allergens.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - August 14, 2014 Category: Allergy & Immunology Authors: M.I. Alvarado, L. Jimeno, F. De La Torre, P. Boissy, B. Rivas, MJ. Lázaro, D. Barber Tags: Original Article: Experimental Allergy and Immunology Source Type: research

Controlling Asthma by Training of Capnometry-Assisted Hypoventilation (CATCH) Versus Slow Breathing: A Randomized Controlled Trial.
Conclusions:Brief interventions aimed at raising PCO2 or slowing respiratory rate provide significant, sustained, and clinically meaningful improvements in asthma control. Raising PCO2 was associated with greater benefits in aspects of lung function and long-term symptoms. Trial Registration:clinicaltrials.gov Identifier: NCT00975273. Background: Hyperventilation has been associated with adverse effects on lung function, symptoms, and well-being in asthma. We examined whether raising end-tidal carbon-dioxide levels (PCO2), compared to slow breathing, was associated with improvements in asthma control, including peak-fl...
Source: Chest - August 14, 2014 Category: Respiratory Medicine Authors: Ritz T, Rosenfield D, Steele AM, Millard MM, Meuret AE Tags: Chest Source Type: research

Gender Differences in Response to Tadalafil in Pulmonary Arterial Hypertension.
Conclusions:Age, gender, baseline functional capacity, and disease etiology are variably associated with the likelihood of achieving clinically relevant responses in patient-important outcomes to PAH-specific therapy such as 6MWD and HRQoL. The increased likelihood of response in men compared to women is a novel finding and may reflect pathophysiologic differences between genders. Background: Pulmonary arterial hypertension (PAH) is a progressive disease with high morbidity and mortality. Current therapies improve symptoms, functional capacity, and in select cases, survival. Little is known about patient factors that m...
Source: Chest - August 14, 2014 Category: Respiratory Medicine Authors: Mathai SC, Hassoun PM, Puhan MA, Zhou Y, Wise RA Tags: Chest Source Type: research

Risk factors for cardiovascular disease in people with idiopathic pulmonary fibrosis: a population based study.
ConclusionSeveral cardiovascular risk factors were more prevalent in people with IPF; however this did not account for the increased rate of IHD in this group of patients. Rationale & Objective: People with idiopathic pulmonary fibrosis (IPF) have been shown to be at an increased risk of cardiovascular disease but reasons for this are unknown. The aim of this study was to compare the prevalence of common cardiovascular risk factors in people with IPF and the general population and establish the incidence of ischaemic heart disease (IHD) and stroke after the diagnosis of IPF, controlling for these risk factors. ...
Source: Chest - August 14, 2014 Category: Respiratory Medicine Authors: Dalleywater W, Powell HA, Hubbard RB, Navaratnam V Tags: Chest Source Type: research

Soil bacterial diversity in degraded and restored lands of Northeast Brazil.
In this study we compare the structure and diversity of bacterial communities in degraded and restored lands in Northeast Brazil and determine the soil biological and chemical properties influencing bacterial communities. We found that land degradation decreased the diversity of soil bacteria as indicated by both reduced operational taxonomic unit (OTU) richness and Shannon index. Soils under native vegetation and restoration had significantly higher bacterial richness and diversity than degraded soils. Redundancy analysis revealed that low soil bacterial diversity correlated with a high respiratory quotient, indicating st...
Source: Antonie van Leeuwenhoek - August 14, 2014 Category: Microbiology Authors: Araújo AS, Borges CD, Tsai SM, Cesarz S, Eisenhauer N Tags: Antonie Van Leeuwenhoek Source Type: research

Electrocardiogram Derived Respiratory Rate from QRS Slopes and R-Wave Angle.
Abstract A method for estimating respiratory rate from electrocardiogram (ECG) signals is presented. It is based on QRS slopes and R-wave angle, which reflect respiration-induced beat morphology variations. The 12 standard leads, 3 leads from vectorcardiogram (VCG), and 2 additional non-standard leads derived from VCG loops were analyzed. The following series were studied as ECG derived respiration (EDR) signals: slope between the peak of Q and R waves, slope between the peak of R and S waves, and the R-wave angle. Information from several EDR signals was combined in order to increase the robustness of estimation. ...
Source: Annals of Biomedical Engineering - August 14, 2014 Category: Biomedical Engineering Authors: Lázaro J, Alcaine A, Romero D, Gil E, Laguna P, Pueyo E, Bailón R Tags: Ann Biomed Eng Source Type: research

What Epidural Opioid Results in the Best Analgesia Outcomes and Fewest Side Effects After Surgery?: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSIONS:: Analgesic outcome, in terms of VAS pain score, was similar between the epidural opioids studied. These similarities in analgesia may reflect the common practices of concurrently using epidural local anesthetics with the opioids and titrating infusion rates according to a patient's pain status. With respect to side effects, the incidence of PONV and possibly pruritus was higher with morphine compared with fentanyl, despite there being similar total opioid consumption between those groups. PMID: 25126704 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - August 14, 2014 Category: Anesthesiology Authors: Youssef N, Orlov D, Alie T, Chong M, Cheng J, Thabane L, Paul J Tags: Anesth Analg Source Type: research

Murine lung injury caused by
Conclusions: GLP and ouabain induced lung injury, as evidenced by increased lung inflammation and hemorrhage. To our knowledge, this is the first report showing GLP induces lung injury. GLP and ouabain are Na/K-ATPase targets, triggering intracellular signaling pathways. We showed p38 activation by GLP-induced lung injury, which was may be linked to Na/K-ATPase inhibition. Lung inflammation induced by GLP was not dependent on TLR4 activation. (Source: Respiratory Research)
Source: Respiratory Research - August 14, 2014 Category: Respiratory Medicine Authors: Cassiano Gonçalves-de-AlbuquerquePatrícia BurthAdriana SilvaIsabel de MoraesFlora OliveiraRicardo SantelliAline FreireGerson de LimaEmilson da SilvaCamila da SilvaVerônica MorandiPatrícia BozzaMauricio Younes-IbrahimHugo de Castro Faria NetoMauro de C Source Type: research

Aerobic exercise improves gastrointestinal motility in psychiatric inpatients.
CONCLUSION: A 12-wk aerobic exercise program can benefit psychiatric inpatients by increasing intestinal motility, possibly decreasing risk of metabolic- and cardiovascular-related disease. PMID: 25132778 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Kim YS, Song BK, Oh JS, Woo SS Tags: World J Gastroenterol Source Type: research

Transport and deposition of pharmaceutical particles in three commercial spacer–MDI combinations
Respiratory drug delivery has been under the research spotlight for the past few decades, mainly due to the high incidence of pulmonary diseases and the fact that this type of delivery offers the highest efficiency for treatment. Despite its invaluable benefits, there are some major drawbacks to respiratory drug delivery, the most important of which being poor delivery efficiency and relatively high drug deposition in undesirable regions, such as the mouth cavity. One way to improve the efficiency of respiratory drug delivery with metered-dose inhalers is placing a respiratory spacer between the inhaler exit and the mouth....
Source: Computers in Biology and Medicine - August 14, 2014 Category: Bioinformatics Authors: A. Yazdani, M. Normandie, M. Yousefi, M.S. Saidi, G. Ahmadi Source Type: research

Arterialised earlobe capillary blood gases in the COPD population.
Abstract Arterialised ear lobe capillary blood (ELCB) gas sampling is a widely used clinical procedure undertaken across both primary and secondary care settings. The prevalence of this sampling method has grown among health professionals, coupled with a growing demand for domiciliary oxygen therapy in the UK, in particular for those who have chronic obstructive pulmonary disease (COPD). Research studies supporting arterialised ELCB gas sampling show inconsistencies in technique, and a survey of respiratory nurses' current practice demonstrated wider inconsistencies. In the absence of national clinical guidelines t...
Source: British Journal of Nursing - August 14, 2014 Category: Nursing Authors: Young J Tags: Br J Nurs Source Type: research

Antimicrobial susceptibility and molecular characterization of Mycobacterium intracellulare in China.
In conclusion, our data demonstrated that clarithromycin and capreomycin revealed highly antimicrobial activities against M. intracellulare isolates, and clarithromycin and amikacin resistance could be detected more readily and rapidly using molecular scanning of corresponding drug target than conventional drug susceptibility testing. We also found that infection by clustered strains was significantly associated with resistance to moxifloxacin. PMID: 25131955 [PubMed - as supplied by publisher] (Source: Infection, Genetics and Evolution)
Source: Infection, Genetics and Evolution - August 14, 2014 Category: Genetics & Stem Cells Authors: Zhao X, Wang Y, Pang Y Tags: Infect Genet Evol Source Type: research

Porcine reproductive and respiratory syndrome virus infection triggers HMGB1 release to promote inflammatory cytokine production.
In this study, we found that PRRSV infection triggers the translocation of HMGB1 from the nucleus to the extracellular milieu in MARC-145 cells and porcine alveolar macrophages. Although HMGB1 has no effect on PRRSV replication, HMGB1 promotes PRRSV-induced NF-κB activation and subsequent expression of inflammatory cytokines through receptors RAGE, TLR2 and TLR4. Our findings show that HMGB1 release, triggered by PRRSV infection, enhances the efficiency of virus-induced inflammatory responses, thereby providing new insights into the pathogenesis of PRRSV infection. PMID: 25129433 [PubMed - as supplied by publisher] (Source: Virology)
Source: Virology - August 14, 2014 Category: Virology Authors: Duan E, Wang D, Luo R, Luo J, Gao L, Chen H, Fang L, Xiao S Tags: Virology Source Type: research