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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

The Impact of Screening Tools on Diagnosis of Chronic Obstructive Pulmonary Disease in Primary Care
Conclusions Office-based assessment can significantly increase COPD diagnosis by primary care physicians. Future trials must evaluate whether screening can improve outcomes for patients with COPD. (Source: American Journal of Preventive Medicine)
Source: American Journal of Preventive Medicine - October 21, 2014 Category: Global & Universal Source Type: research

Chemical characterization and in vitro toxicity of diesel exhaust particulate matter generated under varying conditions
Abstract Epidemiologic studies have linked diesel exhaust (DE) to cardiovascular and respiratory morbidity and mortality, as well as lung cancer. DE composition is known to vary with many factors, although it is unclear how this influences toxicity. We generated eight DE atmospheres by applying a 2 × 2 × 2 factorial design and altering three parameters in a controlled exposure facility: (1) engine load (27 vs 82 %), (2) particle aging (residence time ~5 s vs ~5 min prior to particle collection), and (3) oxidation (with or without ozonation during dilution). Selected exposure concentrations of both die...
Source: Air Quality, Atmosphere and Health - October 21, 2014 Category: Environmental Health Source Type: research

Unique properties of cbb3 H+ channel [Biophysics and Computational Biology]
The respiratory chains of nearly all aerobic organisms are terminated by proton-pumping heme-copper oxygen reductases (HCOs). Previous studies have established that C-family HCOs contain a single channel for uptake from the bacterial cytoplasm of all chemical and pumped protons, and that the entrance of the KC-channel is a conserved glutamate... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 21, 2014 Category: Science Authors: Ahn, Y. O., Mahinthichaichan, P., Lee, H. J., Ouyang, H., Kaluka, D., Yeh, S.–R., Arȷona, D., Rousseau, D. L., Taȷkhorshid, E., Adelroth, P., Gennis, R. B. Tags: PNAS Plus Source Type: research

MERS-CoV entry mediated by furin [Microbiology]
Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus causing high morbidity and mortality in humans. The coronavirus spike (S) protein is the main determinant of viral entry, and although it was previously shown that MERS-CoV S can be activated by various proteases, the details of the mechanisms... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - October 21, 2014 Category: Science Authors: Millet, J. K., Whittaker, G. R. Tags: Biological Sciences Source Type: research

Shear stress upregulates IL‐1β secretion by Chlamydia pneumoniae‐ infected monocytes
Abstract Infectious agents are increasingly implicated in the development and progression of chronic inflammatory diseases. Several lines of evidence suggest that the common intracellular respiratory pathogen, Chlamydia pneumoniae contributes to the well‐established risk factors of atherosclerosis but the exact mechanism is not well understood. It is believed that C. pneumoniae‐infected monocytes travel from the lung to the atherosclerotic foci, during which the cells experience mechanical stimuli due to blood flow. In this work, we characterized the effect of physiological levels of shear stress on C. pneumoniae‐inf...
Source: Biotechnology and Bioengineering - October 21, 2014 Category: Biomedical Science Authors: Aswathi Cheeniyil, Shankar J. Evani, Shatha F. Dallo, Anand K. Ramasubramanian Tags: Tissue Engineering and Delivery Systems Source Type: research

Observational study to characterise 24-hour COPD symptoms and their relationship with patient-reported outcomes: results from the ASSESS study
COPD symptoms are more common in the early morning and day versus the night and over half of the 727 patients studied experienced symptoms during a 24 hour period. These outcomes should be considered when managing the disease. (Source: Respiratory Research)
Source: Respiratory Research - October 21, 2014 Category: Respiratory Medicine Authors: Marc MiravitllesHeinrich WorthJuan Soler CataluñaDavid PriceFernando de BenedettoNicolas RocheNina GodtfredsenThys van der MolenClaes-Göran LöfdahlLaura PadullésAnna Ribera Source Type: research

Lung squamous carcinoma with two paraneoplastic syndromes ‐Dermatomyositis and Lambert‐Eaton myasthenic syndrome
We reported a case of a 60‐year‐old male smoker who presented multiple erythematous lesion for six months with progressive proximal muscular weakness, and developed to dysphonia in two months. His chest computed tomography showed a spiculate pulmonary nodule near the hilar in the right upper lobe and mediastinal lymph nodes enlargement. Lung biopsy showed squamous cell carcinoma. The patients’blood test revealed elevated creatine kinase levels. Electromyography results was consistent with moderate myopathy accompanied with a pattern suggestive of Lambert‐Eaton myasthenic syndrome. So we made the diagnosis of an ove...
Source: The Clinical Respiratory Journal - October 21, 2014 Category: Respiratory Medicine Authors: Yuanrong Dai, Ping Li, Sunshun Yan, Xiaodong Xia, Zhixiong Li, Mengling Xia Tags: Other Source Type: research

Tuberculous pleuritis secondary to Mycobacterium bovis in a veterinarian
Abstract Mycobacterium bovis is a rare cause of tuberculosis in humans, but should be considered in individuals at risk secondary to medical co‐morbidities (notably immunocompromise) or occupational exposure. Most cases are secondary to re‐activation of latent infection in elderly individuals although cases of primary infection still occur, usually involving animal‐to‐human transmission. Pleural fluid culture in the context of suspected tuberculous pleuritis is frequently negative and pleural biopsy significantly increases the likelihood of confirming the diagnosis histologically and microbiologically. Although tho...
Source: The Clinical Respiratory Journal - October 21, 2014 Category: Respiratory Medicine Authors: John P Corcoran, Robert J Hallifax, Henry V Bettinson, Ioannis Psallidas, Najib M Rahman Tags: Original Article Source Type: research

Prenatal administration of all- trans retinoic acid upregulates leptin signaling in hypoplastic rat lungs with experimental congenital diaphragmatic hernia
Conclusion Increased Lep and Lep-R expression after prenatal administration of ATRA in nitrofen-induced PH suggests that ATRA may have therapeutic potential in attenuating CDH-associated PH by stimulating alveolarization and de novo surfactant production. (Source: Pediatric Surgery International)
Source: Pediatric Surgery International - October 21, 2014 Category: Surgery Source Type: research

Parablastomonas arctica gen. nov., sp. nov., a bacterium isolated from high Arctic glacial till.
Abstract A pale yellow pigmented, aerobic bacterium, strain M0-2T, was isolated from a till sample. Its taxonomic position was investigated by using a polyphase approach. Cells are Gram-stain-negative, rod-shaped and motile. Cells reproduce by budding or asymmetric cell division. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain M0-2T belonged to the family Sphingomonadaceae and was closely related to Novosphingobium species (96.4-92.0%), Blastomonas species (94.6%), Sphingopyxis witflariensis W-50T (94.0%), Sphingosinicella soli KSL-125T (93.6%) and Sphingomonas astaxanthinifaciens TDMA-...
Source: International Journal of Systematic and Evolutionary Microbiology - October 21, 2014 Category: Microbiology Authors: Ren L, Chang X, Jiang F, Kan W, Qu Z, Qiu X, Fang C, Peng F Tags: Int J Syst Evol Microbiol Source Type: research

Thiogranum longum gen. nov., sp. nov., a novel obligately chemolithoautotrophic sulfur-oxidizing bacterium of the family Ectothiorhodospiraceae isolated from a hydrothermal field on Suiyo Seamount, and an emended description of the genus Thiohalomonas.
Abstract A novel obligately chemolithoautotrophic sulfur-oxidizing bacterial strain, designated strain gps52(T), was isolated from a rock sample collected near the hydrothermal vents of the Suiyo Seamount in the Pacific Ocean. The cells possessed a Gram-negative type cell wall and contained menaquinone-8(H4) and menaquinone-9(H4) as respiratory quinones, and C16:1ω7cis, C16:0, and C18:1ω7cis as major cellular fatty acids. Neither storage compounds nor extensive internal membranes were observed in the cells. Strain gps52T grew using carbon dioxide fixation and oxidation of inorganic sulfur compounds with oxygen as...
Source: International Journal of Systematic and Evolutionary Microbiology - October 21, 2014 Category: Microbiology Authors: Mori K, Suzuki KI, Yamaguchi K, Urabe T, Hanada S Tags: Int J Syst Evol Microbiol Source Type: research

The association between infections and chemotherapy interruptions among cancer patients: prospective cohort study
We examined causes for delay or cancellation of planned chemotherapy, focusing on mild respiratory infections during the winter. (Source: Journal of Infection)
Source: Journal of Infection - October 21, 2014 Category: Infectious Diseases Authors: Ahmed Taha, Inbal Vinograd, Ali Sakhnini, Noa Eliakim-Raz, Laura Farbman, Rina Baslo, Salomon M. Stemmer, Anat Gafter-Gvili, Leonard Leibovici, Mical Paul Source Type: research

The present and future of tuberculosis vaccinations
The clinical, social, and economic burden of tuberculosis (TB) remains high worldwide, thereby highlighting the importance of TB prevention. The bacilli Calmette-Guérin (BCG) vaccine that is currently available can protect younger children but is less effective in adults, the major source of TB transmission. In addition, the emergence of drug-resistant Mycobacterium tuberculosis (Mtb) strains and the high prevalence of HIV infection have significantly complicated TB prognosis and treatment. Together, these data highlight the need for new and more effective vaccines. (Source: Tuberculosis)
Source: Tuberculosis - October 21, 2014 Category: Respiratory Medicine Authors: Nicola Principi, Susanna Esposito Tags: Review Source Type: research

Human B cells produce chemokine CXCL10 in the presence of specific T cells
The objective of this study was to investigate CXCL10 production by human B cells in response to in vitro stimulation with Mtb antigens. (Source: Tuberculosis)
Source: Tuberculosis - October 21, 2014 Category: Respiratory Medicine Authors: Soren T. Hoff, Ahmed M. Salman, Morten Ruhwald, Pernille Ravn, Inger Brock, Nabila Elsheikh, Peter Andersen, Else Marie Agger Tags: Immunological Aspects Source Type: research

Randomized trial of non-invasive ventilation combined with exercise training in patients with chronic hypercapnic failure due to Chronic Obstructive Pulmonary Disease
Non-invasive ventilation and exercise training might prove beneficial in the management of COPD patients. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 21, 2014 Category: Respiratory Medicine Authors: Eduardo Márquez-Martín, Francisco Ortega Ruiz, Pilar Cejudo Ramos, Jose Luis López-Campos, Borja Valencia Azcona, Emilia Barrot Cortés Source Type: research

Pilot Randomised Controlled Trial to Test Effectiveness of Facemasks in Preventing Influenza-Like Illness Transmission Among Australian Hajj Pilgrims in 2011.
Abstract Studies to determine the effectiveness of facemasks in preventing influenza have been inconclusive, largely due to small sample size. The Hajj pilgrimage, where the incidence of influenza and other respiratory infections is high, provides an excellent opportunity to test the effectiveness of facemasks against syndromic and laboratory-confirmed infections. Hence, a pilot study was conducted among Australian pilgrims to assess the feasibility of such a large-scale trial in the coming years. At the 2011 Hajj, tents were randomised to 'supervised mask use' versus 'no supervised mask use'. Pilgrims with ILI sym...
Source: Infectious Disorders Drug Targets - October 21, 2014 Category: Infectious Diseases Authors: Barasheed O, Almasri N, Badahdah AM, Heron L, Taylor J, McPhee K, Ridda I, Haworth E, Dwyer DE, Rashid H, Booy R Tags: Infect Disord Drug Targets Source Type: research

Type 2 Respiratory Failure and Falls in Elderly Adults: Beware of the Thyroid!
(Source: Journal of the American Geriatrics Society)
Source: Journal of the American Geriatrics Society - October 21, 2014 Category: Geriatrics Authors: Nicola Vargas, Loredana Tibullo, Saverio Carifi, Anna Cucciniello, Emanuela Landi, Maria Rosaria Barbella, Francesco Di Grezia Tags: Letters to the Editor Source Type: research

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease.
Abstract Nonalcoholic fatty liver disease (NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAF...
Source: World Journal of Gastroenterology : WJG - October 21, 2014 Category: Gastroenterology Authors: Paradies G, Paradies V, Ruggiero FM, Petrosillo G Tags: World J Gastroenterol Source Type: research

Interventions for managing asthma in pregnancy.
CONCLUSIONS: Based on eight included trials, of moderate quality overall, no firm conclusions about optimal interventions for managing asthma in pregnancy can be made. Five trials assessing pharmacological interventions did not provide clear evidence of benefits or harms to support or refute current practice. While inhaled magnesium sulphate for acute asthma was shown to reduce exacerbations, this was in one small trial of unclear quality, and thus this finding should be interpreted with caution. Three trials assessing non-pharmacological interventions provided some support for the use of such strategies, however were not ...
Source: Cochrane Database of Systematic Reviews - October 21, 2014 Category: Journals (General) Authors: Bain E, Pierides KL, Clifton VL, Hodyl NA, Stark MJ, Crowther CA, Middleton P Tags: Cochrane Database Syst Rev Source Type: research

Respiratory Mechanics in Mechanically Ventilated Patients.
Abstract Respiratory mechanics refers to the expression of lung function through measures of pressure and flow. From these measurements, a variety of derived indices can be determined, such as volume, compliance, resistance, and work of breathing. Plateau pressure is a measure of end-inspiratory distending pressure. It has become increasingly appreciated that end-inspiratory transpulmonary pressure (stress) might be a better indicator of the potential for lung injury than plateau pressure alone. This has resulted in a resurgence of interest in the use of esophageal manometry in mechanically ventilated patients. End...
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Hess DR Tags: Respir Care Source Type: research

Outcomes for Difficult-to-Wean Subjects After Cardiac Surgery.
CONCLUSIONS: These results suggest that patients needing PMV after combined cardiac surgery may suffer worse outcomes than those needing PMV after simple cardiac surgery. PMID: 25336535 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Vagheggini G, Vlad EP, Mazzoleni S, Bortolotti U, Guarracino F, Ambrosino N Tags: Respir Care Source Type: research

Ventilator Liberation for High-Risk-for-Failure Patients: Improving Value of the Spontaneous Breathing Trial.
Abstract Several patient populations have been identified as high risk for extubation failure despite successful completion of a spontaneous breathing trial (SBT). Extubation failure and subsequent need for emergent re-intubation have been associated with increased morbidity and mortality. In this review, we discuss ways to optimize the value and performance of the SBT in a subgroup of high-risk patients (elderly, cardiac, and/or respiratory failure) to reduce the rate of extubation failure. We recommend the use of T-piece mode, longer duration SBT, and measurement of the rapid shallow breathing index (breathing fr...
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Jeganathan N, Kaplan CA, Balk RA Tags: Respir Care Source Type: research

Endobronchial Valve Placement as Destination Therapy for Recurrent Pneumothorax in the Setting of Advanced Malignancy.
We describe the case of a 68-y-old male with refractory acute myelogenous leukemia presenting with recurrent secondary spontaneous pneumothorax and persistent air leak related to an underlying fungal pneumonia. Endobronchial valve placement allowed for timely chest tube removal and discharge from the hospital, as well as avoidance of a thoracoscopic procedure and pleurodesis. PMID: 25336533 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Gilbert CR, Toth JW, Osman U, Reed MF Tags: Respir Care Source Type: research

A Case of Lung Cancer Originating from Cavitary Mycobacterium xenopi Infection.
Abstract Coexistence of Mycobacterium xenopi with lung cancer has been reported. However, lung cancer originating within a pre-existing cavity caused by M. xenopi has not. A 55-y-old woman with a history of smoking presented with complaints of chronic dry cough, night sweats, and weight loss for several months. Computed tomography (CT) scanning revealed a 3.5-cm irregular thick-walled cavity in the right lung apex. Cultures obtained from a CT-guided biopsy grew M. xenopi. The patient received standard treatment, and her clinical symptoms improved, and the radiographic lesion stabilized. However, 2 y later, a repeat...
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Doshi VK, Kulkarni SR, Kham NM, Kapitan KS Tags: Respir Care Source Type: research

Estimation of Minimal Clinically Important Difference in EQ-5D Visual Analog Scale Score After Pulmonary Rehabilitation in Subjects With COPD.
CONCLUSIONS: Our study shows that, in in-patients with stable moderate-to-severe COPD, EQ-VAS is a valid and reliable tool to assess the responsiveness to PR, with an estimated MCID of 8 points. The EQ-VAS can be a practical alternative to more time-consuming measures of health-related quality of life. PMID: 25336531 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Zanini A, Aiello M, Adamo D, Casale S, Cherubino F, Della Patrona S, Raimondi E, Zampogna E, Chetta A, Spanevello A Tags: Respir Care Source Type: research

Values of Impulse Oscillometry in Healthy Mexican Children and Adolescents.
CONCLUSIONS: In this study, we generated reference equations for each IOS variable in healthy children and adolescents. Although these equations were generated in a Mexican population, they are probably also applicable in other Latin American populations with the same ethnic background. PMID: 25336530 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Gochicoa-Rangel L, Torre-Bouscoulet L, Martínez-Briceño D, Rodríguez-Moreno L, Cantú-González G, Vargas MH Tags: Respir Care Source Type: research

Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD.
CONCLUSIONS: Exhaled levels of H2S were lower in subjects with eosinophilia. Increased levels of exhaled H2S predicted a non-eosinophilic phenotype in our study population. PMID: 25336529 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Zhang J, Wang X, Chen Y, Yao W Tags: Respir Care Source Type: research

Prior Cardiac Surgery Is Independently Associated With Decreased Survival Following Infant Tracheostomy.
CONCLUSIONS: Prior cardiac surgery is independently associated with decreased survival within 1 y following tracheostomy. Clinicians and families of infants with prior cardiac surgery in whom tracheostomy after cardiac surgery is deemed necessary should consider this risk when planning long-term care. PMID: 25336528 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 21, 2014 Category: Respiratory Medicine Authors: Rosner E, Mastropietro CW Tags: Respir Care Source Type: research

Growing up with spinal muscular atrophy with respiratory distress (SMARD1)
This report demonstrates that clinical heterogeneity exists throughout the course of SMARD1. (Source: Neuromuscular Disorders)
Source: Neuromuscular Disorders - October 21, 2014 Category: Neurology Authors: Mark Hamilton, Cheryl Longman, Ann O'Hara, Martin Kirkpatrick, Robert McWilliam Tags: Case report Source Type: research

Laboratory capability and surveillance testing for Middle East respiratory syndrome coronavirus infection in the WHO European Region, June 2013.
PMID: 25323078 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - October 20, 2014 Category: Infectious Diseases Authors: Pereyaslov D, Rosin P, Palm D, Zeller H, Gross D, Brown C, Struelens M, MERS-CoV Working Group Tags: Euro Surveill Source Type: research

Parkinson's disease death rate
Hinz M, Stein A, Cole T (Source: International Journal of COPD)
Source: International Journal of COPD - October 20, 2014 Category: Respiratory Medicine Source Type: research

IGF1 and IGFBP3 in acute respiratory distress syndrome.
PMID: 25319218 [PubMed - in process] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - October 20, 2014 Category: Endocrinology Authors: Ahasic AM, Zhai R, Su L, Zhao Y, Aronis KN, Thompson BT, Mantzoros CS, Christiani DC Tags: Eur J Endocrinol Source Type: research

Exercise-Induced Lowering of Fetuin-A May Increase Hepatic Insulin Sensitivity
Conclusions: Fetuin-A may contribute to exercise training-induced improvements in hepatic insulin resistance, CHO utilization, and inflammation in older obese adults. Further work is required to determine the cellular mechanism(s) of action for fetuin-A because this hepatokine is related to type 2 diabetes risk. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - October 20, 2014 Category: Sports Medicine Tags: Basic Sciences Source Type: research

Dihydromyricetin Improves Physical Performance under Simulated High Altitude
Conclusions: DHM improves physical performance under simulated high-altitude conditions via protecting mitochondrial biogenesis and modulating mitochondrial dynamics in skeletal muscle cells. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - October 20, 2014 Category: Sports Medicine Tags: Basic Sciences Source Type: research

Menthol cigarette smoking in the COPDGene cohort: Relationship with COPD, comorbidities and CT metrics
ConclusionsThese results confirm that menthol cigarettes are not safer than traditional cigarettes and suggest that menthol cigarette smokers may have more frequent severe exacerbations than non‐menthol cigarette smokers. (Source: Respirology)
Source: Respirology - October 20, 2014 Category: Respiratory Medicine Authors: Seoung Ju Park, Marilyn G. Foreman, Dawn L. Demeo, Surya P. Bhatt, Nadia N. Hansel, Robert A. Wise, Xavier Soler, Russell P. Bowler Tags: Original Article Source Type: research

An analysis of commonly reported medical conditions amongst patients receiving dental implants in private practice
ConclusionThe population assessed in this study was a medically diverse group. Clinicians must be familiar with their target demographic and understand how the common comorbidities amongst this patient group can influence clinical decision making and outcomes.This article is protected by copyright. All rights reserved. (Source: Australian Dental Journal)
Source: Australian Dental Journal - October 20, 2014 Category: Dentistry Authors: Stephen Austin, Denise Bailey, Arun Chandu, Mehrnoosh Dastaran, Roy Judge Tags: Original Article Source Type: research

Free‐breathing pediatric MRI with nonrigid motion correction and acceleration
ConclusionWith the proposed methods, diagnosable high‐resolution abdominal volumetric scans can be obtained from free‐breathing data acquisitions. J. Magn. Reson. Imaging 2014. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - October 20, 2014 Category: Radiology Authors: Joseph Y. Cheng, Tao Zhang, Nichanan Ruangwattanapaisarn, Marcus T. Alley, Martin Uecker, John M. Pauly, Michael Lustig, Shreyas S. Vasanawala Tags: Original Research Source Type: research