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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Changes in aerodynamics during vocal cord dysfunction
This study provides new insight on the effects of VCD on respiratory airflow using computational fluid dynamics (CFD) techniques. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - December 15, 2014 Category: Bioinformatics Authors: Dennis O. Frank-Ito, Kristine Schulz, Gina Vess, David L. Witsell Source Type: research

Reliable typing of variants with a small genome fragment
Middle East Respiratory Syndrome coronavirus (MERS-CoV; Family Coronaviridae) may cause severe lower respiratory tract infection in humans [1,2]. Camels are considered the likely animal source for zoonotic infection; sporadic human-to-human transmission does occur, but is considered to be inefficient based on currently available data [3–10]. Until recently, new MERS-CoV infections in humans were reported at a steady low rate reaching ∼200 confirmed human cases early 2014. In March and April 2014, however, a surge of MERS-CoV infections occurred mainly in hospitals around Jeddah, Kingdom of Saudi Arabia (KSA) and United...
Source: Journal of Clinical Virology - December 15, 2014 Category: Virology Authors: Saskia L. Smits, V.Stalin Raj, Suzan D. Pas, Chantal B.E.M. Reusken, Khaled Mohran, Elmoubasher A.B.A. Farag, Hamad E. Al-Romaihi, Mohd M. AlHajri, Bart L. Haagmans, Marion P. Koopmans Source Type: research

Idiopathic Interstitial Pneumonias: A Radiology-Pathology Correlation Based on the Revised 2013 American Thoracic Society-European Respiratory Society Classification System
The idiopathic interstitial pneumonias (IIPs) are a group of diffuse lung diseases that share many similar radiologic and pathologic features. According to the revised 2013 American Thoracic Society-European Respiratory Society classification system, these entities are now divided into major IIPs (idiopathic pulmonary fibrosis, idiopathic nonspecific interstitial pneumonia, respiratory bronchiolitis–associated interstitial lung disease, desquamative interstitial pneumonia, cryptogenic organizing pneumonia, and acute interstitial pneumonia), rare IIPs (idiopathic lymphoid interstitial pneumonia, idiopathic pleuroparenchym...
Source: Current Problems in Diagnostic Radiology - December 14, 2014 Category: Radiology Authors: Michael A. Kadoch, Matthew D. Cham, Mary B. Beasley, Thomas J. Ward, Adam H. Jacobi, Corey D. Eber, Maria L. Padilla Source Type: research

Changes in leukocyte subsets of pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus and relationships with viral load and fetal outcome
The objectives of the present study were to investigate changes in peripheral blood mononuclear cell populations in third trimester pregnant females infected with type 2 PRRSv (NVSL 97–7895) and to analyze potential relationships with viral load and fetal mortality rate. PRRSv infection caused a massive, acute drop in total leukocyte counts affecting all PBMC populations by two days post infection. Except for B cells, cell counts started to rebound by day six post infection. Our data also show a greater decrease of naïve B cells, T-helper cells and cytolytic T cells than their respective effector or memory counterparts....
Source: Veterinary Research - December 14, 2014 Category: Veterinary Research Source Type: research

Uncoupling protein-2 attenuates palmitoleate protection against the cytotoxic production of mitochondrial reactive oxygen species in INS-1E insulinoma cells
Publication date: April 2015 Source:Redox Biology, Volume 4 Author(s): Jonathan Barlow , Verena Hirschberg Jensen , Charles Affourtit High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-induced ROS are mostly mitochondrial: oxidation of MitoSOX, a mitochondria-targeted superoxide probe, is increased by palmitate, whilst oxidation of the equivalent non-targeted probe is unaffected....
Source: Redox Biology - December 14, 2014 Category: Biology Source Type: research

Role of H2O2 in the oxidative effects of zinc exposure in human airway epithelial cells
Publication date: 2014 Source:Redox Biology, Volume 3 Author(s): Phillip A. Wages , Robert Silbajoris , Adam Speen , Luisa Brighton , Andres Henriquez , Haiyan Tong , Philip A. Bromberg , Steven O. Simmons , James M. Samet Human exposure to particulate matter (PM) is a global environmental health concern. Zinc (Zn2+) is a ubiquitous respiratory toxicant that has been associated with PM health effects. However, the molecular mechanism of Zn2+ toxicity is not fully understood. H2O2 and Zn2+ have been shown to mediate signaling leading to adverse cellular responses in the lung and we have previously demonstrated Zn2+ to cau...
Source: Redox Biology - December 14, 2014 Category: Biology Source Type: research

Identification of a novel herpesvirus in captive Eastern box turtles (Terrapene carolina carolina)
Publication date: Available online 13 December 2014 Source:Veterinary Microbiology Author(s): Richard R. Sim , Terry M. Norton , Ellen Bronson , Matthew C. Allender , Nancy Stedman , April L. Childress , James F.X. Wellehan Jr Herpesviruses are significant pathogens of chelonians which most commonly cause upper respiratory tract disease and necrotizing stomatitis. Herpesvirus infection was identified in two populations of captive Eastern box turtles (Terrapene carolina carolina) using histopathology and polymerase chain reaction (PCR) with DNA sequencing. Necrotizing lesions with eosinophilic to amphophilic intranuclear ...
Source: Veterinary Microbiology - December 14, 2014 Category: Veterinary Research Source Type: research

PI3K signalling in inflammation
This article is part of a Special Issue entitled Phosphoinositides. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 14, 2014 Category: Lipidology Source Type: research

Nanometer-long Ge-imogolite nanotubes cause sustained lung inflammation and fibrosis in rats
Conclusions: We showed that nm-long Ge-imogolites persist in the lung and promote genotoxicity, sustained inflammation and fibrosis, indicating that short high aspect ratio nanomaterials should not be considered as innocuous materials. Our data also suggest that Ge-imogolite structure and external surface determine their toxic activity. (Source: Particle and Fibre Toxicology)
Source: Particle and Fibre Toxicology - December 14, 2014 Category: Toxicology Authors: Sybille van den BruleEmilie BeckersPerrine ChaurandWei LiuSaloua IbouraadatenMihaly Palmai-PallagFrancine UwambayinemaYousof YakoubAstrid AvellanClément LevardVincent HaufroidEtienne MarbaixAntoine ThillDominique LisonJérôme Rose Source Type: research

Non-invasive ventilation in premature infants
Non-invasive respiratory support in preterm infants traditionally consisted of the application of continuous distending positive pressure at the nose. More recently, the continuous distending pressure has been combined with intermittent positive pressure cycles using conventional ventilators or devices developed specifically for this purpose. One of the common terms used to refer to these modalities is nasal intermittent positive pressure ventilation (NIPPV). These modalities or devices vary depending on the peak pressure of each cycle, how fast it rises, the duration of the cycle and cycling frequency and whether the posi...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Claure, N., Bancalari, E. Tags: Drugs: cardiovascular system, Child health, Infant health, Neonatal health, Airway biology, Arrhythmias Editorials Source Type: research

Proportional assist: time to re-evaluate a 'new' mode of ventilation for neonates?
Over the past three decades, a myriad of new ventilatory modalities have been developed for use in neonatal critical care. Most of these modalities are based on a specific physiological rationale. Supportive evidence is sparse and where it exists mostly comes from studies which are short-term and have a physiological variable as their primary outcome. Randomised controlled trials with clinically important long-term outcomes are rare in this field. In the absence of high quality evidence, the clinical practice of neonatal mechanical respiratory support varies widely between countries, between units and even within units dep...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Schulze, A., Davis, P. G. Tags: Obstetrics and gynaecology, Child health, Infant health, Neonatal and paediatric intensive care, Neonatal health, Airway biology, Neonatal intensive care, Mechanical ventilation Editorials Source Type: research

Is synchronised NIPPV more effective than NIPPV and NCPAP in treating apnoea of prematurity (AOP)? A randomised cross-over trial
Conclusions Flow-SNIPPV seems more effective than NIPPV and NCPAP in reducing the incidence of desaturations, bradycardias and central apnoea episodes in preterm infants. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Gizzi, C., Montecchia, F., Panetta, V., Castellano, C., Mariani, C., Campelli, M., Papoff, P., Moretti, C., Agostino, R. Tags: Clinical trials (epidemiology), Drugs: cardiovascular system, Child health, Infant health, Neonatal health, Airway biology, Arrhythmias Original articles Source Type: research

Effects of synchronisation during SiPAP-generated nasal intermittent positive pressure ventilation (NIPPV) in preterm infants
Conclusions The SiPAP synchronisation system triggered rapidly with most spontaneous breaths, but did not result in larger tidal volumes. When the RR was >55/min, the SiPAP delivered fewer pressure peaks at lower pressures. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Owen, L. S., Morley, C. J., Davis, P. G. Tags: Child health, Infant health, Neonatal health, Airway biology Original articles Source Type: research

Bi-level CPAP does not improve gas exchange when compared with conventional CPAP for the treatment of neonates recovering from respiratory distress syndrome
Conclusions At similar mean airway pressures, SiPAP does not improve CO2 removal, oxygenation or other studied physiological parameters with the exception of mean blood pressure, which was not clinically significant. Trial registration number NCT01053455. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Lampland, A. L., Plumm, B., Worwa, C., Meyers, P., Mammel, M. C. Tags: Drugs: cardiovascular system, Hypertension, Child health, Neonatal and paediatric intensive care, Neonatal intensive care, Arrhythmias Original articles Source Type: research

Crossover study of proportional assist versus assist control ventilation
Conclusions These results suggest that PAV compared with ACV may have physiological advantages for prematurely born infants who remain ventilated after the first week after birth. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Bhat, P., Patel, D.-S., Hannam, S., Rafferty, G. F., Peacock, J. L., Milner, A. D., Greenough, A. Tags: Airway biology, Mechanical ventilation Original articles Source Type: research

Monitoring tidal volumes in preterm infants at birth: mask versus endotracheal ventilation
Conclusions During neonatal mask ventilation, distention of the upper respiratory tract contributes to the tidal volumes measured and should be taken into account when targeting tidal volumes during mask ventilation. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: van Vonderen, J. J., Hooper, S. B., Krabbe, V. B., Siew, M. L., te Pas, A. B. Tags: Child health, Infant health, Neonatal health Original articles Source Type: research

A metronome for pacing manual ventilation in a neonatal resuscitation simulation
Conclusions The use of a metronome improved the accuracy of delivered RR during manual PPV. Novel approaches to deliver an accurate RR during manual PPV need to be tested in more realistic scenarios. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Cocucci, C., Madorno, M., Aguilar, A., Acha, L., Szyld, E., Musante, G. Tags: Airway biology, Resuscitation Original articles Source Type: research

European neonatal intensive care nursing research priorities: an e-Delphi study
Conclusions The results of this study might support developing a nursing research strategy for the nursing section of the European Society of Paediatric and Neonatal Intensive Care. In addition, this may promote more European researcher collaboratives for neonatal nursing research. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 14, 2014 Category: Perinatology & Neonatology Authors: Wielenga, J. M., Tume, L. N., Latour, J. M., van den Hoogen, A. Tags: Immunology (including allergy), Pain (neurology), Nursing, Child health, Neonatal and paediatric intensive care, Neonatal health, End of life decisions (palliative care), Hospice, Unwanted effects / adverse reactions, Neonatal intensive care, End of life Source Type: research

Meta-analysis of laparoscopic vs open cholecystectomy in elderly patients.
CONCLUSION: Further high-quality evidence is necessary to draw definite conclusions, although best-available evidence supports the selective use of laparoscopy in this patient population. PMID: 25516678 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 14, 2014 Category: Gastroenterology Authors: Antoniou SA, Antoniou GA, Koch OO, Pointner R, Granderath FA Tags: World J Gastroenterol Source Type: research

Effects of laparoscopic cholecystectomy on lung function: A systematic review.
CONCLUSION: Laparoscopic cholecystectomy seems to be associated with less postoperative derangement of lung function compared to the open procedure. PMID: 25516676 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - December 14, 2014 Category: Gastroenterology Authors: Bablekos GD, Michaelides SA, Analitis A, Charalabopoulos KA Tags: World J Gastroenterol Source Type: research

Surfactant for meconium aspiration syndrome in term and late preterm infants.
CONCLUSIONS: In infants with MAS, surfactant administration may reduce the severity of respiratory illness and decrease the number of infants with progressive respiratory failure requiring support with ECMO. The relative efficacy of surfactant therapy compared to, or in conjunction with, other approaches to treatment including inhaled nitric oxide, liquid ventilation, surfactant lavage and high frequency ventilation remains to be tested. PMID: 25504256 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - December 14, 2014 Category: Journals (General) Authors: El Shahed AI, Dargaville PA, Ohlsson A, Soll R Tags: Cochrane Database Syst Rev Source Type: research

Environmental Tobacco Smoke Exposure, Urine CC‐16 Levels, and Asthma Outcomes among Chinese Children
ConclusionsOur study shows long‐term exposure to ETS was associated with urinary CC‐16 among children without asthma.This article is protected by copyright. All rights reserved. (Source: Allergy)
Source: Allergy - December 13, 2014 Category: Allergy & Immunology Authors: Ya‐Nan Ma, Zhengmin Qian, Jing Wang, Eugene Rodemich, Yungling Leo Lee, Xue‐Feng Lv, Yu‐Qin Liu, Yang Zhao, Mei‐Meng Huang, Yang Liu, Jing Sun, Qin‐Cheng He, Guang‐Hui Dong Tags: Original Article: Airway Diseases Source Type: research

90. Strength and respiratory evaluation in ALS: A follow up study
Amyotrophic lateral sclerosis is a degenerative disease involving upper and lower motor neurons, thus leading to progressive spasticity and weakness. Purpose of this study is to relate reduction in cMAP amplitude to functional impairment in ALS patients. We recruited 156 patients, 50 with bulbar, 106 with spinal onset. Patients were periodically visited every 3month; medial plantar, ulnar and frenic nerves were examined in each patient. ALSFRS-R scale and MRC scale for strength were submitted; forced vital capacity and oxygen saturation were measured. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - December 13, 2014 Category: Neuroscience Authors: M. Ceccanti, C. Cambieri, G. Capua, D. Lopergolo, V. Frasca, M. Gabriele, M. Inghilleri Source Type: research

Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection
CONCLUSIONS: Cyanosis and lymphocytosis are independent predictors for pertussis in children up to 6 months old. OBJETIVO: Identificar preditores clínicos, laboratoriais e radiológicos da infecção por Bordetella pertussis. MÉTODOS: Trabalho retrospectivo, com análise de prontuários clínicos de todos os indivíduos submetidos ao diagnóstico molecular (qPCR) para B. pertussis de setembro de 2011 à janeiro de 2013. Foram revistos dados clínicos e laboratoriais, incluindo informações sobre idade, sexo, sinais/sintomas, tempo de hospitalização, contagens de células sanguíneas, exames de imagem, co-infecção c...
Source: Revista Paulista de Pediatria - December 13, 2014 Category: Pediatrics Source Type: research

Prevalence and clinical characteristics of wheezing in children in the first year of life, living in Cuiabá, Mato Grosso, Brazil
CONCLUSIONS: The prevalence of recurrent wheezing and physician-diagnosed asthma in infants were lower compared with those observed in other Brazilian studies. Recurrent wheezing had early onset and high morbity. OBJETIVO: Determinar a prevalência e as características clínicas da sibilância em lactentes (12-15 meses) residentes em Cuiabá (MT). MÉTODOS: Pais e/ou responsáveis pela criança foram entrevistados e responderam ao questionário escrito padronizado do "Estudio Internacional de Sibilancia en Lactantes" (EISL) - fase 3, em unidades básicas de saúde por ocasião da vacinação de rotina ou durante visitas ...
Source: Revista Paulista de Pediatria - December 13, 2014 Category: Pediatrics Source Type: research

Pulmonary function of children with acute leukemia in maintenance phase of chemotherapy
CONCLUSION: Children with acute leukemia, myeloid or lymphoid, during the maintenance phase of chemotherapy exhibited unchanged spirometric variables and maximal expiratory pressure; However, there was a decrease in inspiratory muscle strength. OBJETIVO: O objetivo desse estudo foi avaliar a função pulmonar de crianças com leucemia aguda. MÉTODOS: Trata-se de um estudo observacional do tipo analítico transversal com 34 crianças, divididas nos grupos A (17 crianças com leucemia aguda na fase de manutenção do tratamento quimioterápico) e B (17 crianças saudáveis). Os grupos foram pareados em relação ao sexo, i...
Source: Revista Paulista de Pediatria - December 13, 2014 Category: Pediatrics Source Type: research

Overnight Pulse Oximetry for Evaluation of Sleep Apnea among Children with Trisomy 21
Conclusions:In a retrospective cohort of children with trisomy 21, McGill oximetry scores of 3 or 4 reliably identified patients with marked OSDB. The possibility of central apneas causing hypoxemia must be considered in those with McGill Score 2. With these caveats, oximetry screening should be considered when developing streamlined protocols for early intervention to treat OSDB in this population.Citation:Coverstone AM, Bird M, Sicard M, Tao Y, Grange DK, Cleveland C, Molter D, Kemp JS. Overnight pulse oximetry for evaluation of sleep apnea among children with trisomy 21. J Clin Sleep Med 2014;10(12):1309-1315. (Source: ...
Source: Journal of Clinical Sleep Medicine : JCSM - December 13, 2014 Category: Sleep Medicine Source Type: research

Medication discrepancies in older patients admitted to non-geriatric wards: An exploratory study
Discussion & conclusion Medication discrepancies occurring at admission to non-geriatric wards are common in older inpatients and their potentially moderate clinical impact reinforces their importance to patient safety. (Source: European Geriatric Medicine)
Source: European Geriatric Medicine - December 13, 2014 Category: Geriatrics Source Type: research

External fixation of distal femoral fractures in adults’ multicentre retrospective study of 43 patients
Conclusion Our data support provisional external fixation followed by early conversion to internal fixation in patients with extensively compounded DFFs; patients with multiple fractures requiring several surgical procedures; and polytrauma patients awaiting hemodynamic, respiratory, or neurological stabilization. Level of evidence IV, retrospective study. (Source: Orthopaedics and Traumatology: Surgery and Research)
Source: Orthopaedics and Traumatology: Surgery and Research - December 13, 2014 Category: Orthopaedics Source Type: research

Pulsed direct and constant direct currents in the pilocarpine iontophoresis sweat chloride test
Conclusions: The performance of the CST with CDC and PDC with CD of 0.14 to 0.21 mA/cm2 showed efficacy in steps of stimulation and collection of sweat, without side effects. The optimal stimulation time and sweat collection were, respectively, 10 and 30 min. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - December 13, 2014 Category: Respiratory Medicine Authors: Carla GomezMaria ServidoniFernando MarsonPaulo CanaveziAdriana VinagreEduardo CostaAntonio RibeiroMaria RibeiroAdyleia ToroCelia PavanMichelle RondonSonia LorenaFrancisco VieiraJose Ribeiro Source Type: research

Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients
Background: Acute exacerbations of COPD (AECOPD) are common and strongly influence disease severity and relative healthcare costs. Vitamin D deficiency is frequent among COPD patients and its contributory role in disease exacerbations is widely debated. Our aim was to assess the relationship of serum vitamin D levels with COPD severity and AECOPD. Methods: Serum vitamin D (25-hydroxyvitamin D) levels were measured in 97 COPD patients and related to lung function, comorbidities, FEV1 decline, AECOPD and hospital admission during the previous year. Results: Most patients (96%) had vitamin D deficiency, which was severe in 35...
Source: Respiratory Research - December 13, 2014 Category: Respiratory Medicine Authors: Andrei MalinovschiMonica MasoeroMichela BellocchiaAntonio CiuffredaPaolo SolidoroAlessio MatteiLorena MercanteEnrico HefflerGiovanni RollaCaterina Bucca Source Type: research

encoding DPPR synthase involved in cell wall synthesis is associated with ethambutol resistance in
Ethambutol (EMB) is a frontline antituberculosis drug for the treatment of tuberculosis (TB). The embB gene is responsible for EMB resistance in only about 50-60% clinical isolates of Mycobacterium tuberculosis, and the mechanism of resistance in the remaining EMB resistant strains is not clear. We assessed the role of the ubiA gene encoding 5-phospho-α-d-ribose-1-diphosphate: decaprenyl-phosphate 5-phosphoribosyltransferase (DPPR synthase, UbiA) involved in decaprenylphosphoryl-D-arabinose (DPA) pathway for cell wall synthesis in EMB resistance. (Source: Tuberculosis)
Source: Tuberculosis - December 13, 2014 Category: Respiratory Medicine Authors: Lei He, Xiaobo Wang, Peng Cui, Jialin Jin, Jiazhen Chen, Wenhong Zhang, Ying Zhang Tags: Drug Discovery and Resistance Source Type: research

)Gene SNP rs5743618 is Associated with Increased Risk for Tuberculosis in Han Chinese Children
Toll-like receptor 1 (TLR1) recognizes lipopeptides with TLR2, and affects immune response to Mycobacterium tuberculosis infection. Here, we report results of the first case-control pediatric study of the TLR1 single-nucleotide polymorphisms and susceptibility to tuberculosis (TB). A pediatric case-control study enrolled 340 TB patients and 366 healthy controls, all Han Chinese from North China. Significant differences of the allelic and genotypic distributions of rs5743618 in TLR1 gene were observed between TB group and control group and, G allele of rs5743618 was associated with increased risk for TB (OR: 2.40, 95%CI: 1....
Source: Tuberculosis - December 13, 2014 Category: Respiratory Medicine Authors: Hui Qi, Lin Sun, Xirong Wu, Yaqiong Jin, Jing Xiao, Shengfeng Wang, Chen Shen, Ping Chu, Zhan Qi, Fang Xu, Yajie Guo, Weiwei Jiao, Jianling Tian, Adong Shen Tags: Host Genetics of Susceptibility Source Type: research

Prevalence and determinants of chronic obstructive pulmonary disease in HIV infected patients in an african country with low level of tobacco smoking
Little is known on the association between HIV infection and chronic obstructive pulmonary disease (COPD) in sub-Saharan Africa. We assessed the prevalence and investigated the determinants of COPD according to HIV status in a reference centre for HIV and tuberculosis (TB) management in Cameroon. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - December 13, 2014 Category: Respiratory Medicine Authors: Eric Walter Pefura-Yone, Gaspary Fodjeu, André Pascal kengne, Nicolas Roche, Christopher Kuaban Source Type: research

Predictive value of C-reactive protein in critically ill patients who develop acute lung injury
Conclusions Although CRP has widely been considered to be a marker of systemic inflammation, our findings show that higher levels of CRP are associated with decreased mortality, organ failure, and need for mechanical ventilation among patients with ALI. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - December 13, 2014 Category: Respiratory Medicine Source Type: research

Thromboprophylaxis does not prevent venous thromboembolism after major surgery
Conclusion Despite the use of thromboprophylaxis, PE and DVT were important complications of major abdominal and major orthopedic surgery. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - December 13, 2014 Category: Respiratory Medicine Source Type: research

NICE guidelines to family doctors on diagnosis of pneumonia
Publication date: Available online 12 December 2014 Source:The Lancet Respiratory Medicine Author(s): Hilary Marshall (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 13, 2014 Category: Respiratory Medicine Source Type: research

First-line crizotinib shows promise in patients with NSCLC
Publication date: Available online 12 December 2014 Source:The Lancet Respiratory Medicine Author(s): Sanjeet Bagcchi (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 13, 2014 Category: Respiratory Medicine Source Type: research

Mexico's complex respiratory public health picture
Publication date: Available online 12 December 2014 Source:The Lancet Respiratory Medicine Author(s): Bryant Furlow (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 13, 2014 Category: Respiratory Medicine Source Type: research

Patients with lung disease at risk of bowel disease
Publication date: Available online 12 December 2014 Source:The Lancet Respiratory Medicine Author(s): Sanjay Tanday (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - December 13, 2014 Category: Respiratory Medicine Source Type: research

Occupational and Environmental Exposures and Cancers in Developing Countries
Conclusions A precise quantification of the burden of human cancer attributable to environmental and occupational exposures in LMICs is uncertain. Although the prevalence of carcinogenic exposures has been reported to be high in many such countries, the effects of the exposures have not been studied due to varying country-specific limitations, some of which include lack of resources and government support. (Source: Annals of Global Health)
Source: Annals of Global Health - December 13, 2014 Category: Global & Universal Source Type: research

Characterization of chlorate reduction in the haloarchaeon Haloferax mediterranei
Conclusions Hfx. mediterranei pNarGH has its active site on the outer-face of the cytoplasmic membrane and reacts with chlorate and perchlorate. Biochemical characterisation of this enzymatic activity suggests that Hfx. mediterranei or its pure pNarGH could be of great interest for waste water treatments or to better understand biological chlorate reduction in early Earth or Martian environments. General significance some archaea species reduce (per)chlorate. However, results here presented as well as those recently reported by Liebensteiner and co-workers [1] suggest that complete perchlorate reduction in archaea follows ...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - December 13, 2014 Category: Biochemistry Source Type: research

Comparative study between dexmedetomidine-ketamine and fentanyl-ketamine combinations for sedation in patients undergoing extracorporeal shock wave lithotripsy. A randomized double blinded study
Conclusion Dexmedetomidine/ketamine combination was accompanied by more prolonged analgesia in the recovery period, prolonged sedation, and delayed request of first dose analgesia with less nausea and vomiting than fentanyl/ketamine combination. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - December 13, 2014 Category: Anesthesiology Source Type: research

Selecting models for a respiratory protection program: What can we learn from the scientific literature?
Conclusion Analysis of these studies indicated that it is difficult to directly use the scientific literature to inform the FFR selection process because of differences in study populations, methodologies, and other factors. Although there does not appear to be a single best fitting FFR, studies demonstrate that fit testing programs can be designed to successfully fit nearly all workers with existing products. Comfort and usability are difficult to quantify. Among the studies found, no significant differences were noted. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - December 13, 2014 Category: Infectious Diseases Source Type: research