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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

The Energy Crisis Revisited: AMP-activated Protein Kinase and the Mammalian Hypoxic Ventilatory Response.
PMID: 27128704 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Gozal D Tags: Am J Respir Crit Care Med Source Type: research

Harnessing the Power of the Host: Improving Dendritic Cell Vaccines for Malignant Pleural Mesothelioma.
PMID: 27128703 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Peikert T, Sterman DH Tags: Am J Respir Crit Care Med Source Type: research

Two Faces of Sarcoidosis. A Genetic Insight?
PMID: 27128702 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Millar A Tags: Am J Respir Crit Care Med Source Type: research

How Can We Protect Susceptible Individuals from the Adverse Cardiovascular Effects of Air Pollution?
PMID: 27128701 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Mills NL, Miller MR Tags: Am J Respir Crit Care Med Source Type: research

Launching into the Deep: Does the Pulmonary Microbiota Promote Chronic Lung Inflammation and Chronic Obstructive Pulmonary Disease Pathogenesis?
PMID: 27128700 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Sze MA, Morris A Tags: Am J Respir Crit Care Med Source Type: research

Eosinophils as Biomarkers of Chronic Obstructive Pulmonary Disease Exacerbation Risk. Maybe Just for Some?
PMID: 27128699 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Wedzicha JA Tags: Am J Respir Crit Care Med Source Type: research

Cross-Talk between Epithelial Cells and Type 2 Immune Signaling. The Role of IL-25.
PMID: 27128698 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - May 1, 2016 Category: Respiratory Medicine Authors: Gordon ED, Locksley RM, Fahy JV Tags: Am J Respir Crit Care Med Source Type: research

Minimally invasive repair of Morgagni hernia – A multicenter case series
Publication date: Available online 30 April 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): R. Lamas-Pinheiro, J. Pereira, F. Carvalho, P. Horta, A. Ochoa, M. Knoblich, J. Henriques, T. Henriques-Coelho, J. Correia-Pinto, P. Casella, J. Estevão-Costa Children may benefit from minimally invasive surgery (MIS) in the correction of Morgagni hernia (MH). The present study aims to evaluate the outcome of MIS through a multicenter study. National institutions that use MIS in the treatment of MH were included. Demographic, clinical and operative data were analyzed. Thirteen patients with M...
Source: Revista Portuguesa de Pneumologia - May 1, 2016 Category: Respiratory Medicine Source Type: research

Pulmonary tuberculosis epidemiology in Coimbra's District (2000–2011): Information is essential to understand high risk groups
Publication date: Available online 30 April 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): R. Eufrásio, M. Alcobia, L. Correia (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - May 1, 2016 Category: Respiratory Medicine Source Type: research

Bronchodilating effect of deep inspirations in asthma and chronic cough
The pathophysiologic processes distinguishing classic asthma (CA), cough-variant asthma (CVA), and methacholine (MCh)-induced cough but normal airway sensitivity (COUGH) are inadequately understood and may be a result of differences in the ability to bronchodilate following a deep inspiration (DI). The purpose of this study was to compare the bronchodilating effect of DIs in individuals with CA, CVA, and COUGH using high-dose MCh. Individuals aged 18-65 yr with CA or suspected CVA completed high-dose MCh testing to a maximum change in forced expiratory volume in 1 s (FEV1) of 50% from baseline (MAX). Impulse oscillometry (...
Source: Journal of Applied Physiology - May 1, 2016 Category: Physiology Authors: V. Wasilewski, N., Fisher, T., Turcotte, S. E., Fisher, J. T., Lougheed, M. D. Tags: ARTICLES Source Type: research

Predictors of obstructive sleep apnoea‐hypopnea severity and oral appliance therapy efficacy by using lateral cephalometric analysis
This study suggested that cephalometric analysis is useful for predicting OSAH severity and OA therapy efficacy. (Source: Journal of Oral Rehabilitation)
Source: Journal of Oral Rehabilitation - May 1, 2016 Category: Dentistry Authors: Y. Sakamoto, S. Yanamoto, S. Rokutanda, T. Naruse, N. Imayama, M. Hashimoto, A. Nakamura, N. Yoshida, N. Tanoue, T. Ayuse, H. Yoshimine, M. Umeda Tags: Original Article Source Type: research

Asthma related medication use and exacerbations in children and adolescents with type 1 diabetes
ConclusionsT1DM is associated with statistically significantly higher asthma medication use after the onset of T1DM, especially in the 1st year after the onset of diabetes. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Fariba Ahmadizar, Patrick C. Souverein, Hubertus G.M. Arets, Anthonius de Boer, Anke H. Maitland‐van der Zee Tags: Original Article: Asthma Source Type: research

Pulmonary manifestations of prolidase deficiency
ConclusionsProlidase deficiency is frequently associated with various pulmonary manifestations, including extensive cystic changes that may be life endangering. The differential diagnosis of bilateral cystic changes should include prolidase deficiency, and pulmonary evaluation should be performed in patients with prolidase deficiency. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Vered Nir, Anat Ilivitky, Fahed Hakim, Ronen Bar Yoseph, Michal Gur, Hana Mandel, Lea Bentur Tags: Original Article: Outcomes Source Type: research

Feasibility of nitrogen multiple‐breath washout in inexperienced children younger than 7 years
ConclusionsMBW was only feasible in one quarter of inexperienced children <7 years applying strict consensus criteria. Low FRC variability and low breathing variability seem to be mutually exclusive at this age group. Specific consensus recommendations for MBW in preschool children seem, thus, warranted. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Sophie Yammine, Selina Summermatter, Florian Singer, Roger Lauener, Philipp Latzin Tags: Original Article: Diagnostic Testing Source Type: research

Children with lower respiratory tract infections and serum 25‐hydroxyvitamin D3 levels: A case–control study
ConclusionsChildren with lower respiratory tract infections in Guatemala had low 25‐hydroxyvitamin D3 levels. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Angel Alfonso Velarde López, Jeffrey S. Gerber, Mary B. Leonard, Dawei Xie, Rita Schinnar, Brian L. Strom Tags: Original Article: Respiratory Infections Source Type: research

Inhalation of tobramycin using simulated cystic fibrosis patient profiles
ConclusionsOur findings indicate that the T‐326 Inhaler provides reliable drug delivery at flow rates likely to be achieved by a broad spectrum of patients with CF. Importantly, forceful inhalation was not required to achieve a robust TLDin vitro. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Alfred Haynes, David Geller, Jeffry Weers, Brian Ament, Richard Pavkov, Richard Malcolmson, Laurie Debonnett, Paul Mastoridis, Anthony Yadao, Silvia Heuerding Tags: Original Article: Cystic Fibrosis Source Type: research

Changes to a pediatric sleep disordered breathing clinic improve wait‐times and clinic efficiency
ConclusionA targeted, streamlined clinic using electronic‐questionnaires for uncomplicated patients can improve wait‐times for children being referred to pediatric respiratory medicine for evaluation of sleep disordered breathing. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - May 1, 2016 Category: Respiratory Medicine Authors: Amanda Lau, Chris Ewing, Juanita Gnanapragasam, Carina Majaesic, Joanna MacLean, Piush J. Mandhane Tags: Original Article: Sleep & Breathing Source Type: research

The role of hyaluronan in the pathobiology and treatment of respiratory disease
Hyaluronan, a ubiquitous naturally occurring glycosaminoglycan, is a major component of the extracellular matrix, where it participates in biological processes that include water homeostasis, cell-matrix signaling, tissue healing, inflammation, angiogenesis, and cell proliferation and migration. There are emerging data that hyaluronan and its degradation products have an important role in the pathobiology of the respiratory tract. We review the role of hyaluronan in respiratory diseases and present evidence from published literature and from clinical practice supporting hyaluronan as a novel treatment for respiratory disea...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Garantziotis, S., Brezina, M., Castelnuovo, P., Drago, L. Tags: CALL FOR PAPERS Source Type: research

Flow-cytometric method for simultaneous analysis of mouse lung epithelial, endothelial, and hematopoietic lineage cells
Flow cytometry is a powerful tool capable of simultaneously analyzing multiple parameters on a cell-by-cell basis. Lung tissue preparation for flow cytometry requires creation of a single-cell suspension, which often employs enzymatic and mechanical dissociation techniques. These practices may damage cells and cause cell death that is unrelated to the experimental conditions under study. We tested methods of lung tissue dissociation and sought to minimize cell death in the epithelial, endothelial, and hematopoietic lineage cellular compartments. A protocol that involved flushing the pulmonary circulation and inflating the ...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Singer, B. D., Mock, J. R., D'Alessio, F. R., Aggarwal, N. R., Mandke, P., Johnston, L., Damarla, M. Tags: INNOVATIVE METHODOLOGY Source Type: research

Microparticles as biomarkers of lung disease: enumeration in biological fluids using lipid bilayer microspheres
Extracellular vesicles, specifically microparticles (MPs), are rapidly gaining attention for their capacity to act as biomarkers for diagnosis, prognosis, or responsiveness to therapy in lung disease, in keeping with the concept of precision medicine. However, MP analysis by high-sensitivity flow cytometry (FCM) is complicated by a lack of accurate means for MP enumeration. To address this gap, we report here an enhanced FCM MP gating and enumeration technique based on the use of novel engineered lipid bilayer microspheres (LBMs). By comparison of LBM-based MP enumeration with conventional bead- or fluorescent-based FCM en...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: McVey, M. J., Spring, C. M., Semple, J. W., Maishan, M., Kuebler, W. M. Tags: CALL FOR PAPERS Source Type: research

Regulation of myofibroblast differentiation by cardiac glycosides
Myofibroblast differentiation is a key process in pathogenesis of fibrotic diseases. Cardiac glycosides (ouabain, digoxin) inhibit Na+-K+-ATPase, resulting in increased intracellular [Na+]-to-[K+] ratio in cells. Microarray analysis suggested that increased intracellular [Na+]/[K+] ratio may promote the expression of cyclooxygenase-2 (COX-2), a critical enzyme in the synthesis of prostaglandins. Given antifibrotic effects of prostaglandins through activation of protein kinase A (PKA), we examined if cardiac glycosides stimulate COX-2 expression in human lung fibroblasts and how they affect myofibroblast differentiation. Ou...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: La, J., Reed, E. B., Koltsova, S., Akimova, O., Hamanaka, R. B., Mutlu, G. M., Orlov, S. N., Dulin, N. O. Tags: CALL FOR PAPERS Source Type: research

{alpha}-Smooth muscle actin is an inconsistent marker of fibroblasts responsible for force-dependent TGF{beta} activation or collagen production across multiple models of organ fibrosis
Fibrosis is a common pathological sequela of tissue injury or inflammation, and is a major cause of organ failure. Subsets of fibroblasts contribute to tissue fibrosis in multiple ways, including generating contractile force to activate integrin-bound, latent TGFβ and secreting excess amounts of collagens and other extracellular matrix proteins (ECM) that make up pathologic scar. However, the precise fibroblast subsets that drive fibrosis have been poorly understood. In the absence of well-characterized markers, α-smooth muscle actin (αSMA) is often used to identify pathologic fibroblasts, and some authors...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Sun, K.-H., Chang, Y., Reed, N. I., Sheppard, D. Tags: CALL FOR PAPERS Source Type: research

Hyperinsulinemia adversely affects lung structure and function
There is limited knowledge regarding the consequences of hyperinsulinemia on the lung. Given the increasing prevalence of obesity, insulin resistance, and epidemiological associations with asthma, this is a critical lacuna, more so with inhaled insulin on the horizon. Here, we demonstrate that insulin can adversely affect respiratory health. Insulin treatment (1 μg/ml) significantly (P < 0.05) increased the proliferation of primary human airway smooth muscle (ASM) cells and induced collagen release. Additionally, ASM cells showed a significant increase in calcium response and mitochondrial respiration upon insulin ex...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Singh, S., Bodas, M., Bhatraju, N. K., Pattnaik, B., Gheware, A., Parameswaran, P. K., Thompson, M., Freeman, M., Mabalirajan, U., Gosens, R., Ghosh, B., Pabelick, C., Linneberg, A., Prakash, Y. S., Agrawal, A. Tags: ARTICLES Source Type: research

Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension
An increase in cytosolic free Ca2+ concentration ([Ca2+]cyt) in pulmonary arterial smooth muscle cells (PASMC) is a major trigger for pulmonary vasoconstriction and a critical stimulation for PASMC proliferation and migration. Previously, we demonstrated that expression and function of calcium sensing receptors (CaSR) in PASMC from patients with idiopathic pulmonary arterial hypertension (IPAH) and animals with experimental pulmonary hypertension (PH) were greater than in PASMC from normal subjects and control animals. However, the mechanisms by which CaSR triggers Ca2+ influx in PASMC and the implication of CaSR in the de...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Tang, H., Yamamura, A., Yamamura, H., Song, S., Fraidenburg, D. R., Chen, J., Gu, Y., Pohl, N. M., Zhou, T., Jimenez-Perez, L., Ayon, R. J., Desai, A. A., Goltzman, D., Rischard, F., Khalpey, Z., Black, S. M., Garcia, J. G. N., Makino, A., Yuan, J. X. J. Tags: ARTICLES Source Type: research

Reduced mucociliary clearance in old mice is associated with a decrease in Muc5b mucin
Respiratory infections are a major cause of morbidity and mortality in the elderly. Previous reports have suggested that mucociliary clearance (MCC) is impaired in older individuals, but the cause is unclear. To unravel the mechanisms responsible for the age-associated decline in MCC, we investigated the MCC system in young (3 mo) and old (2 yr) C57BL/6 mice. We found that old mice had significantly reduced MCC function in both the upper and lower airways compared with young mice. Measurement of bioelectric properties of isolated tracheal and bronchial tissue revealed a significant decrease in Cl– secretion, suggesti...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Grubb, B. R., Livraghi-Butrico, A., Rogers, T. D., Yin, W., Button, B., Ostrowski, L. E. Tags: ARTICLES Source Type: research

Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function
In this study we tested the hypothesis that endogenous KGF plays a role in the maintenance of innate pulmonary defense against gram-negative bacterial infections. KGF-deficient mice exhibited delayed clearance of Escherichia coli from the lungs, attenuated phagocytosis by AM, and decreased antimicrobial activity in bronchoalveolar lavage (BAL) fluid, due in part to reductions in levels of surfactant protein A, surfactant protein D, and lysozyme. These immune deficits were accompanied by lower alveolar type II epithelial cell counts and reduced alveolar type II epithelial cell expression of collectin and lysozyme genes on a...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Gardner, J. C., Wu, H., Noel, J. G., Ramser, B. J., Pitstick, L., Saito, A., Nikolaidis, N. M., McCormack, F. X. Tags: ARTICLES Source Type: research

The Src family tyrosine kinases src and yes have differential effects on inflammation-induced apoptosis in human pulmonary microvascular endothelial cells
Endothelial cells are essential for normal lung function: they sense and respond to circulating factors and hemodynamic alterations. In inflammatory lung diseases such as acute respiratory distress syndrome, endothelial cell apoptosis is an inciting event in pathogenesis and a prominent pathological feature. Endothelial cell apoptosis is mediated by circulating inflammatory factors, which bind to receptors on the cell surface, activating signal transduction pathways, leading to caspase-3-mediated apoptosis. We hypothesized that yes and src have differential effects on caspase-3 activation in human pulmonary microvascular e...
Source: AJP: Lung Cellular and Molecular Physiology - May 1, 2016 Category: Respiratory Medicine Authors: Nelin, L. D., White, H. A., Jin, Y., Trittmann, J. K., Chen, B., Liu, Y. Tags: ARTICLES Source Type: research

Pneumocystis pneumonia associated with human immunodeficiency virus infection without elevated (1 → 3)-β-D glucan: A case report
We report a case of HIV-PCP not associated with elevated serum (1 → 3)-β-D glucan and highlight how HIV-PCP cannot be completely ruled out if (1 → 3)-β-D glucan is negative. (Source: Respiratory Medicine Case Reports)
Source: Respiratory Medicine Case Reports - May 1, 2016 Category: Respiratory Medicine Source Type: research

A spatial difference-in-differences analysis of the impact of sugarcane production on respiratory diseases
This article presents a new variety of a spatial diff-in-diff model to control for the effects of sugarcane production in neighboring non-producing regions. This method is an addition to the Spatial Econometrics literature, as it includes spatial effects on treated and untreated regions, so that the effects on both producing and surrounding non-producing regions can be properly estimated. The results indicate that the effects on the producing regions are 78% larger than if the effects on the surrounding areas were ignored. Moreover, the effects on the surrounding areas, typically ignored in other studies, are relevant, and...
Source: Regional Science and Urban Economics - May 1, 2016 Category: Science Source Type: research

Rotenone-stimulated superoxide release from mitochondrial complex I acutely augments L-type Ca2+ current in A7r5 aortic smooth muscle cells
Voltage-gated L-type Ca2+ current (ICa,L) induces contraction of arterial smooth muscle cells (ASMCs), and ICa,L is increased by H2O2 in ASMCs. Superoxide released from the mitochondrial respiratory chain (MRC) is dismutated to H2O2. We studied whether superoxide per se acutely modulates ICa,L in ASMCs using cultured A7r5 cells derived from rat aorta. Rotenone is a toxin that inhibits complex I of the MRC and increases mitochondrial superoxide release. The superoxide content of mitochondria was estimated using mitochondrial-specific MitoSOX and HPLC methods, and was shown to be increased by a brief exposure to 10 μM rot...
Source: AJP: Heart and Circulatory Physiology - May 1, 2016 Category: Cardiology Authors: Ochi, R., Dhagia, V., Lakhkar, A., Patel, D., Wolin, M. S., Gupte, S. A. Tags: CALL FOR PAPERS Source Type: research

Clinical trials: registration and transparency.
PMID: 27132270 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2016 Category: Respiratory Medicine Authors: Sotgiu G, Humbert M, Dinh-Xuan AT, Migliori GB Tags: Eur Respir J Source Type: research

Increasing implementation and delivery of pulmonary rehabilitation: key messages from the new ATS/ERS policy statement.
PMID: 27132269 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - May 1, 2016 Category: Respiratory Medicine Authors: Vogiatzis I, Rochester CL, Spruit MA, Troosters T, Clini EM,  on behalf of the American Thoracic Society/European Respiratory Society Task Force on Policy in Pulmonary Rehabilitation Tags: Eur Respir J Source Type: research