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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Therapeutic novelties of inhaled corticosteroids and bronchodilators in asthma
Publication date: August 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 33 Author(s): Fabio L.M. Ricciardolo , Francesco Blasi , Stefano Centanni , Paola Rogliani Orally inhaled agents are a key therapeutic class for treatment of asthma. Inhaled corticosteroids (ICS) are the most effective anti-inflammatory treatment for asthma thus representing the first-line therapy and bronchodilators complement the effects of ICSs. A significant body of evidence indicates that addition of a β2-agonist to ICS therapy is more effective than increasing the dose of ICS monotherapy. In this paper, pharmacological featu...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

In vitro effect of ursolic acid on the inhibition of Mycobacterium tuberculosis and its cell wall mycolic acid
In this study, the action of UA against Mycobacterium tuberculosis H37Ra was evaluated, and the inhibitory concentration was found to range between 10 and 20 μg/ml in a resazurin assay and MGIT 960 instrument. The total mycolic acid in UA-treated H37Ra was detected and compared with INH-treated and non-treated bacterium by LC-MS/MS. Quantitative LC-MS/MS data confirmed that both UA and INH decreased mycolic acid biosynthesis in a dose-dependent manner. Thin-layer chromatogram (TLC) analysis showed that all mycolic acid subtypes were affected by UA treatment in the wild type but not in strains resistant to UA. Electron mi...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Bradykinin and capsaicin induced airways obstruction in the guinea pig are platelet dependent
Conclusion Airways obstruction induced by bombesin, capsaicin and bradykinin is platelet dependent, but not secondary to platelet aggregation. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Serum levels of tumor necrosis factor-related apoptosis-inducing ligand correlate with the severity of pulmonary hypertension
In conclusion, serum sTRAIL could be a biomarker for diagnosis and effective therapy for PH patients. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Efficacy of erdosteine 900 versus 600 mg/day in reducing oxidative stress in patients with COPD exacerbations: Results of a double blind, placebo-controlled trial
Conclusions Results confirm the antioxidant dose- and time-dependent activity of erdosteine, and support the utility of including erdosteine it in the therapeutic strategy for the prevention and treatment of oxidative stress-induced inflammation, which frequently leads to AECOPD occurrence. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Oxidative stress as activators of sensory nerves for cough
Publication date: Available online 19 June 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Thomas E. Taylor–Clark Excessive activation of the cough reflex is a major clinical problem in respiratory diseases. The cough reflex is triggered by activation of nociceptive sensory nerve terminals innervating the airways by noxious stimuli. Oxidative stress is a noxious stimuli associated with inhalation of pollutants and inflammatory airway disease. Here, we discuss recent findings that oxidative stress, in particular downstream of mitochondrial dysfunction, evokes increased electrical activity in airway ...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Cough in obstructive sleep apnoea
Publication date: Available online 9 June 2015 Source:Pulmonary Pharmacology & Therapeutics Author(s): Kevin Chan , Alvin Ing , Surinder S. Birring Obstructive Sleep Apnoea (OSA) has recently been reported to be a cause of chronic cough. It should be considered when cough remains unexplained following investigations and treatments for common causes. The presence of nocturnal cough, snoring and gastro-oesophageal reflux may be helpful in identifying patients who require further investigation. Daytime somnolence is often absent. Continuous positive airway pressure (CPAP) therapy has been reported to be effective in...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Respiratory infections management: Still a challenge
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Francesco Blasi , Antoni Torres (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Antibiotic prophylaxis in COPD: Why, when, and for whom?
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Marc Miravitlles , Antonio Anzueto One of the main goals of treatment of chronic obstructive pulmonary disease (COPD) is the prevention of exacerbations. Bronchodilators and anti-inflammatories are the first line therapy for treatment of COPD; however, these drugs are not effective in suppressing all infective exacerbations. In fact, the use of inhaled corticosteroids in patients with COPD and chronic bronchial infection may even increase the bacterial load in the airways and increase the risk of pneumonia. In this cont...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Pneumococcal vaccines and the prevention of community-acquired pneumonia
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Susanna Esposito , Nicola Principi Community-acquired pneumonia (CAP) is a disease that frequently affects children and adults throughout the world. As it places a considerable burden on society and, particularly, healthcare resources, any means of reducing its incidence and impact arouses great interest. A substantial number of paediatric and adult CAP cases are due to Streptococcus pneumoniae but, fortunately, there are effective vaccines available that are likely to have a significant impact on CAP-related medical, s...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

New antimicrobial approaches to gram positive respiratory infections
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Adamantia Liapikou , Catia Cilloniz , Josep Mensa , Antonio Torres Nowadays, we face growing resistance among gram-positive and gram-negative pathogens that cause respiratory infection in the hospital and in the community. The spread of penicillin- and macrolide-resistant pneumococci, Community–acquired methicillin-resistant staphylococcus aureus (Ca-MRSA), the emergence of glycopeptide-resistant staphylococci underline the need for underline the need for therapeutic alternatives. A number of new therapeutic agents, w...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Facing multi-drug resistant tuberculosis
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Giovanni Sotgiu , Giovanni Battista Migliori Multi-drug resistant tuberculosis (MDR-TB) is caused by Mycobacterium tuberculosis strains resistant to at least two of the most effective anti-tuberculosis drugs (i.e., isoniazid and rifampicin). Therapeutic regimens based on second- and third-line anti-tuberculosis medicines showed poor efficacy, safety, and tolerability profiles. It was estimated that in 2012 the multi-drug resistant tuberculosis incidence ranged from 300,000 to 600,000 cases, mainly diagnosed in the Easte...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Therapeutic approach to respiratory infections in lung transplantation
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Carolina Clajus , Francesco Blasi , Tobias Welte , Mark Greer , Thomas Fuehner , Marco Mantero Lung transplant recipients (LTRs) are at life-long risk for infections and disseminated diseases owing to their immunocompromised state. Besides organ failure and sepsis, infection can trigger acute and chronic graft rejection which increases mortality. Medical prophylaxis and treatment are based on comprehensive diagnostic work-up including previous history of infection and airway colonisation to reduce long-term complication...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Current and future therapies for invasive aspergillosis
Publication date: June 2015 Source:Pulmonary Pharmacology & Therapeutics, Volume 32 Author(s): Matteo Bassetti , Davide Pecori , Paola Della Siega , Silvia Corcione , Francesco Giuseppe De Rosa Invasive fungal infections have increase worldwide and represent a threat for immunocompromised patients including HIV-infected, recipients of solid organ and stem cell transplants, and patients receiving immunosuppressive therapies. High mortality rates and difficulties in early diagnosis characterize pulmonary fungal infections. Invasive pulmonary aspergillosis has been reviewed focussing on therapeutic management. Altho...
Source: Pulmonary Pharmacology and Therapeutics - June 26, 2015 Category: Respiratory Medicine Source Type: research

Unexpected responses to EGFR inhibition in NSCLC
Publication date: Available online 25 June 2015 Source:Respiratory Medicine Case Reports Author(s): Giulia M. Stella , Claudio Valizia , Michele Zorzetto , Simona Inghilleri , Adele Valentini , Roberto Dore , Sara Colombo , Francesco Valentino , Giulio Orlandoni , Patrizia Morbini The presence of activating mutations of the epidermal growth factor receptor (EGFR)-gene identifies a distinct and clinically relevant molecular subset of non-small-cell lung cancer. It is now well demonstrated that EGFR tyrosine kinase inhibitors (TKIs) gefitinib and erlotinib are superior to standard chemotherapy in this subset of tumors. Nev...
Source: Respiratory Medicine Case Reports - June 26, 2015 Category: Respiratory Medicine Source Type: research

Does a geographical context explain regional variation in child malnutrition in India?
Conclusion The findings suggest that both spatial effect and morbidity, including individual and household factors have significant impact on malnutrition among children. Understanding these relationships can facilitate design of intervention programs. Clearly tackling the problem of malnutrition in India will require multisectoral interventions, targeted at all levels of social organization. (Source: Journal of Public Health)
Source: Journal of Public Health - June 26, 2015 Category: Health Management Source Type: research

Mass chemical casualties: Treatment of 41 patients with burns by anhydrous ammonia
Conclusion This mass casualty incident of anhydrous ammonia leakage caused potential devastating effects to the society, especially to the victims and their families. Early first-aid organization, emergency management, triage, and evacuation were of paramount importance, especially rapid evaluation of the severity of inhalation injury, and subsequent corresponding medical treatment. The prognosis of ammonia burns was poor and the sequelae were severe. Management and treatment lessons were drawn from this mass casualty chemical burn incident. (Source: Burns)
Source: Burns - June 26, 2015 Category: Dermatology Source Type: research

Bilateral vocal fold immobility: a 13 year review of etiologies, management and the utility of the empey index
Conclusion: The EI and EDI have limited use in evaluating patients with who have variable upper airway obstruction, but may be helpful in monitoring changes in patients’ airway status. (Source: Journal of Otolaryngology - Head and Neck Surgery)
Source: Journal of Otolaryngology - Head and Neck Surgery - June 26, 2015 Category: ENT & OMF Authors: Maria BrakeJennifer Anderson Source Type: research

Moving Toward Prime Time: Host Signatures for Diagnosis of Respiratory Infections
(Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - June 26, 2015 Category: Infectious Diseases Authors: Tsalik, E. L., McClain, M., Zaas, A. K. Tags: EDITORIAL COMMENTARIES Source Type: research

Live Attenuated Influenza Virus Increases Pneumococcal Translocation and Persistence Within the Middle Ear
Conclusions. While LAIV vaccination is safe and effective at reducing IAV and coinfection with influenza virus and bacteria, LAIV may increase bacterial transmigration to the middle ear and could thus increase the risk of clinically relevant acute otitis media. These data warrant further investigations into interactions between live attenuated viruses and naturally colonizing bacterial pathogens. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - June 26, 2015 Category: Infectious Diseases Authors: Mina, M. J., Klugman, K. P., Rosch, J. W., McCullers, J. A. Tags: VIRUSES Source Type: research

Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults
Conclusions. Transcriptional profiling is a helpful tool for diagnosis of LRTI. (Source: The Journal of Infectious Diseases)
Source: The Journal of Infectious Diseases - June 26, 2015 Category: Infectious Diseases Authors: Suarez, N. M., Bunsow, E., Falsey, A. R., Walsh, E. E., Mejias, A., Ramilo, O. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research

Histoplasmosis diagnosed after arthroscopy of the knee: case report
Publication date: Available online 25 June 2015 Source:The Brazilian Journal of Infectious Diseases Author(s): Lorenzo Falster , Maurício B. Marin , João Luiz Ellera Gomes Fungal arthritis is a rare complication of arthroscopic surgeries, but its possibility should always be considered due its deleterious effects on any joint. Infection caused by the fungus Histoplasma capsulatum is the most common cause of respiratory tract infections by fungi, meanwhile histoplasmosis arthritis is more rare than all other fungal infections. However, their atypical forms of arthritis and the importance of early diagnosis and treatment...
Source: The Brazilian Journal of Infectious Diseases - June 26, 2015 Category: Infectious Diseases Source Type: research

Severe childhood Guillain‐Barré syndrome associated with Mycoplasma pneumoniae infection: a case series
We report 7 children with recent M. pneumoniae infection and severe GBS that presented to two European medical centers from 1992–2012. Severe GBS was defined as the occurrence of respiratory failure, central nervous system (CNS) involvement, or death. Five children had GBS, one Bickerstaff brain stem encephalitis (BBE), and one acute‐onset chronic inflammatory demyelinating polyneuropathy (A‐CIDP). The 5 patients with severe GBS were derived from an original cohort of 66 children with GBS. In this cohort, 17 children (26%) had a severe form of GBS and 47% of patients with M. pneumoniae infection presented with severe...
Source: Journal of the Peripheral Nervous System - June 26, 2015 Category: Neurology Authors: Patrick M. Meyer Sauteur, Joyce Roodbol, Annette Hackenberg, Marie‐Claire Y. de Wit, Cornelis Vink, Christoph Berger, Enno Jacobs, Annemarie M.C. van Rossum, Bart C. Jacobs Tags: RESEARCH REPORT Source Type: research

Non‐invasive ventilation is useful in paediatric intensive care units if children are appropriately selected and carefully monitored
ConclusionNIV is useful in PICUs if children are appropriately selected and carefully monitored. Technological advances and future clinical research will improve its use and success rate in PICU. (Source: Acta Paediatrica)
Source: Acta Paediatrica - June 26, 2015 Category: Pediatrics Authors: Pierre Demaret, André Mulder, Isabelle Loeckx, Marc Trippaerts, Frédéric Lebrun Tags: Review Article Source Type: research

Obraz kliniczny rabdomiolizy u hospitalizowanych dzieci
Conclusions The main cause of rhabdomyolysis in children is viral infection, and the disease is mild. (Source: Pediatria Polska)
Source: Pediatria Polska - June 26, 2015 Category: Pediatrics Source Type: research

Problem diagnostyczny: gorączkujący nastolatek z rzadkim zespołem chorobowym
Publication date: Available online 15 May 2015 Source:Pediatria Polska Author(s): Paweł Małecki , Agnieszka Gałek , Jadwiga Małdyk , Ludomiła Machowska , Katarzyna Jończyk-Potoczna , Katarzyna Derwich Haemophagocytic syndrome (hemophagocytic lymphohistiocytosis, HLH) is a rare hematologic disorder which manifests itself by inflammatory reaction caused by incorrect activation of immune cells. A 16-year-old boy was admitted to the hospital with a high fever, respiratory distress, dyspnea, rash and hepatosplenomegaly. The differential diagnosis initially considered infectious mononucleosis and Kawasaki disease. Eventu...
Source: Pediatria Polska - June 26, 2015 Category: Pediatrics Source Type: research

Obraz kliniczny i powikłania odry u dzieci na podstawie ogniska epidemicznego w Poznaniu w 2014 roku
Publication date: May–June 2015 Source:Pediatria Polska, Volume 90, Issue 3 Author(s): Paweł Małecki , Anna Mania , Paweł Kemnitz , Katarzyna Mazur-Melewska , Katarzyna Jończyk-Potoczna , Wojciech Służewski , Magdalena Figlerowicz Thanks to compulsory vaccination schedules measles does not belong to everyday clinical practice. Recently, many local outbreaks have been noticed. In the winter and early summer of 2014 22 cases of measles were diagnosed in the Department of Infectious Diseases and Child Neurology of the University of Medical Sciences in Poznań. Basing on the medical records it has been found that tha...
Source: Pediatria Polska - June 26, 2015 Category: Pediatrics Source Type: research

Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis pulmonary exacerbation
ConclusionsOur findings provide putative metabolite biomarkers for future study and allow for hypothesis generation about the pathophysiology of CF pulmonary exacerbation. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - June 26, 2015 Category: Respiratory Medicine Authors: Theresa A. Laguna, Cavan S. Reilly, Cynthia B. Williams, Cole Welchlin, Chris H. Wendt Tags: Original Article: Cystic Fibrosis Source Type: research

Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients
Conclusions: The results indicate the potential role of the studied TSGs in the differentiation of NSCLC histopathological subtypes. The significant differences in RASSF1A expression levels between NSCLC and macroscopically unchanged lung tissue highlight its possible diagnostic role in lung cancer in situ recognition. High percentage of lung tumor samples with simultaneous RASSF1A decreased expression and gene promoter methylation indicates its epigenetic silencing. However, DNMT overexpression doesn’t seem to be a critical determinate of its promoter hypermethylation. (Source: Respiratory Research)
Source: Respiratory Research - June 26, 2015 Category: Respiratory Medicine Authors: Dorota Pastuszak-LewandoskaJacek KordiakMonika Migdalska-S¿kKarolina CzarneckaAdam AntczakPawe¿ GórskiEwa NawrotJustyna Kisza¿kiewiczDaria Doma¿skaEwa Brzezia¿ska-Lasota Source Type: research

Five Questions Critical Care Educators Should Ask About Simulation-Based Medical Education
Simulation is now commonly used in health care education, and a growing body of evidence supports its positive impact on learning. However, simulation-based medical education (SBME) involves a range of modalities, instructional methods, and presentations associated with different advantages and limitations. This review aims at better understanding the nature of SBME, its theoretic and proven benefits, its delivery, and the challenges posed by SBME. Areas requiring further research and development are also discussed. (Source: Clinics in Chest Medicine)
Source: Clinics in Chest Medicine - June 26, 2015 Category: Respiratory Medicine Authors: Dominique Piquette, Vicki R. LeBlanc Source Type: research

Reply to “Misconceptions in the assessment of cough peak flow measurements for extubation or decanulation protocols”
Publication date: Available online 26 June 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): J.C. Winck , C. LeBlanc , J.L. Soto , F. Plano (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - June 26, 2015 Category: Respiratory Medicine Source Type: research

Southern California tightens rules on air pollution
Publication date: Available online 25 June 2015 Source:The Lancet Respiratory Medicine Author(s): Roxanne Nelson (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 26, 2015 Category: Respiratory Medicine Source Type: research

A new chapter in therapy for cystic fibrosis
Publication date: Available online 24 June 2015 Source:The Lancet Respiratory Medicine Author(s): Diana Bilton (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 26, 2015 Category: Respiratory Medicine Source Type: research

Achalasia with Megaesophagus and Tracheal Compression in a Young Patient: A Case Report
Conclusion This report emphasizes that physicians should be alert and consider airway obstruction and signs of dyspnea as severe and threatening symptoms in extensive cases of achalasia with megaesophagus. Early surgical treatment provides a therapeutic option to obviate the occurrence of acute respiratory distress and consecutive complications. In particular, difficulties in intubation prior to surgery must be considered. Due to potential tracheomalacia, the status of a “bull frog neck” in achalasia, including severe tracheal compression caused by megaesophagus with concomitant cervical swelling, may also lead to extu...
Source: International Journal of Surgery Case Reports - June 26, 2015 Category: Surgery Source Type: research

High risk of delisting or death in liver transplant candidates following infections: Results from the North American consortium for the study of end‐stage liver disease
Because Model for End‐Stage Liver Disease (MELD) scores at the time of liver transplantation (LT) increase nationwide, patients are at an increased risk for delisting by becoming too sick or dying while awaiting transplantation. We quantified the risk and defined the predictors of delisting or death in patients with cirrhosis hospitalized with an infection. North American Consortium for the Study of End‐Stage Liver Disease (NACSELD) is a 15‐center consortium of tertiary‐care hepatology centers that prospectively enroll and collect data on infected patients with cirrhosis. Of the 413 patients evaluated, 136 were lis...
Source: Liver Transplantation - June 26, 2015 Category: Transplant Surgery Authors: K. Rajender Reddy, Jacqueline G. O'Leary, Patrick S. Kamath, Michael B. Fallon, Scott W. Biggins, Florence Wong, Heather M. Patton, Guadalupe Garcia‐Tsao, Ram M. Subramanian, Leroy R. Thacker, Jasmohan S. Bajaj, Tags: Original Article Source Type: research

Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan
Saffold cardiovirus (SAFV) belongs to the Cardiovirus genus of Picornaviridae family, which includes other pathogenic viruses involved in human hand, foot and mouth diseases (HFMD) such as enteroviruses [1,2]. The Cardiovirus genus includes two species: Theilovirus and Encephalomyocarditis virus. A newly identified Theilovirus named SAFV has been isolated from an 8-month-old child with fever of unknown origin in 2007 and designated as SAFV genotype 1 (SAFV-1) [1,3]. SAFV is distinct from Theiler’s murine encephalomyelitis virus (TMEV), Vilyuisk human encephyalomyelitis virus (VHEV) and Theiler-like rat virus (TRV) making...
Source: Journal of Clinical Virology - June 26, 2015 Category: Virology Authors: Tsuey-Li Lin, Ting-Han Lin, Shu-Chun Chiu, Yuan-Pin Huang, Cheng-Mao Ho, Chia-Chi Lee, Ho-Sheng Wu, Jih-Hui Lin Source Type: research

Markers for upper limb dysfunction in Amyotrophic Lateral Sclerosis using analysis of typing activity
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving upper and lower limb function, as well as bulbar and respiratory muscles (Andersen et al., 2012; Miller et al., 2013). Most ALS patients (85 to 90%) need assistive devices at some stage during disease progression, to assist in communication and social interaction (Beukelman et al., 2011; Brownlee and Bruening, 2012). Depending on disease stage, different interface technologies are required to enhance autonomy. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - June 26, 2015 Category: Neuroscience Authors: Ana Londral, Susana Pinto, Mamede de Carvalho Source Type: research

The Effect of Body Mass Index on Post-Vaccination Maternal and Neonatal Pertussis Antibody Levels
The bacterium, Bordatella pertussis, is responsible for pertussis, a highly contagious respiratory infection which most commonly affects young children. Pertussis is particularly dangerous to infants under one year of age who may present with periods of potentially fatal apnea (Cortese et al, 2008). The Centers for Disease Control (CDC) reported 48,277 cases of pertussis in 2012 in the United States, the highest reported number of cases since 1955 (CDC, 2012). Infants cannot be vaccinated against pertussis until approximately two months of age and are thus susceptible to pertussis during this time period. (Source: Journal ...
Source: Journal of Reproductive Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Manisha Gandhi, Sridevi Devaraj, Haleh Sangi-Haghpeykar, Joan Mastrobattista Source Type: research

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.
CONCLUSIONS: In the RV in rats with SPH, there is a major shift in metabolic substrate preference, largely due to decreased fatty acid uptake. PMID: 26115672 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - June 26, 2015 Category: Respiratory Medicine Authors: Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez MJ, Smith-Jones P, Serkova NJ, Tuder RM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Junctional abnormalities in human airway epithelial cells expressing delF508 CFTR.
We examined changes to CFTR function, tight junctions, and gap junctions in NuLi-1 (CFTRwt/wt) and CuFi-5 (CFTRΔF508/ΔF508). Cells were studied at air-liquid interface (ALI) and compared to primary human bronchial epithelial cells. Based on fluorescent lectin binding, the phenotype of the NuLi-1 and CuFi-5 at week 8 resembled serous, glycoprotein-rich airway cells. After 7 weeks at ALI, CuFi-5 cells possessed 130% of the ENaC activity and 17% of the CFTR activity found in NuLi-1. In both cell types, expression levels of CFTR were comparable to CFTR levels found in primary airway epithelia. Transepithelial resistance (TER...
Source: Am J Physiol Lung Ce... - June 26, 2015 Category: Respiratory Medicine Authors: Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research