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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Physicochemical characteristics of nanomaterials that affect pulmonary inflammation
The increasing manufacture and use of products based on nanotechnology raises concerns for both workers and consumers. Various studies report induction of pulmonary inflammation after inhalation exposure to nanoparticles, which can vary in aspects such as size, shape, charge, crystallinity, chemical composition, and dissolution rate. Each of these aspects can affect their toxicity, although it is largely unknown to what extent. The aim of the current review is to analyse published data on inhalation of nanoparticles to identify and evaluate the contribution of their physicochemical characteristics to the onset and developm...
Source: Particle and Fibre Toxicology - April 11, 2014 Category: Toxicology Authors: Hedwig BraakhuisMargriet ParkIlse GosensWim De JongFlemming Cassee Source Type: research

Epithelial‐mesenchymal transitions in bronchopulmonary dysplasia of newborn rats
ConclusionEMT of AT2 cells occurred in the hyperoxia‐induced newborn rat BPD model and resulted in attenuated alveolar development as a portion of the myofibroblasts accumulated in the lung originated from AT2 cells via EMT. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 11, 2014 Category: Respiratory Medicine Authors: Haiping Yang, Jianhua Fu, Xindong Xue, Li Yao, Lin Qiao, Ana Hou, Linlin Jin, Yujiao Xing Tags: Original Article: Neonatal Lung Disease Source Type: research

Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial
Conclusion: Whole body vibration during hospitalised exacerbations did not cause procedure-related adverse events and induced clinically significant benefits regarding exercise capacity and health-related quality of life that were associated with increased serum levels of irisin, a marker of muscle activity.Trial registration: German Clinical Trials Register DRKS00005979. Registered 17 March 2014. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 11, 2014 Category: Respiratory Medicine Authors: Timm GreulichChristoph NellJanine KoepkeJuliane FechtelMaja FrankeBernd SchmeckDaniel HaidSandra ApeltSilke FilipovicKlaus KennSabina JanciauskieneClaus VogelmeierAndreas Koczulla Source Type: research

Shifting paradigms of nontuberculous mycobacteria in cystic fibrosis
Important paradigms of pulmonary disease with nontuberculous mycobacteria (NTM) are currently shifting based on an increasing attention within the field of cystic fibrosis (CF). These shifts are likely to benefit the management of all patients with pulmonary NTM, regardless of underlying pathology. Currently several key areas are being revised: The first outbreak of human NTM transmission has been proven and new evidence of biofilm growth in vivo has been demonstrated. A better understanding of the clinical impact of NTM infection has led to increased diagnostic vigilance and new recommendations for lung transplantation ar...
Source: Respiratory Research - April 11, 2014 Category: Respiratory Medicine Authors: Tavs QvistTania PresslerNiels HøibyTerese Katzenstein Source Type: research

Serum albumin and HCO3- regulate separate pools of ATP in human spermatozoa
STUDY QUESTION Do the known capacitating agents HCO3– and serum albumin regulate the generation of ATP required for sperm motility and capacitation? SUMMARY ANSWER Serum albumin and HCO3– seem to regulate two separate pools of ATP by different mechanisms in human spermatozoa. WHAT IS KNOWN ALREADY Sperm capacitation is a maturation process that naturally occurs in the female reproductive tract preparing the sperm cell for fertilization. It is a highly energy-depending process as it involves hyperactive motility and substantial levels of protein phosphorylation. STUDY DESIGN, SIZE, DURATION Human sperm cells ...
Source: Human Reproduction - April 11, 2014 Category: Reproduction Medicine Authors: Hereng, T. H., Elgstoen, K. B. P., Eide, L., Rosendal, K. R., Skalhegg, B. S. Tags: Andrology Source Type: research

Applying Metabolomics to Uncover Novel Biology in ARDS.
Abstract A better understanding of the pathogenesis and the resolution of the acute respiratory distress syndrome (ARDS) is needed. While some progress has been made with the use of protein biomarkers and candidate gene studies in understanding the pathobiology of ARDS, we propose that new studies that measure the chemical breakdown products of cellular metabolism (metabolomics) may provide new insights into ARDS, in part because the metabolomics targets a later point in the genomics cascade than is possible with studies of DNA, RNA and protein biomarkers. Technological advances have made large-scale metabolomic pr...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 11, 2014 Category: Cytology Authors: Rogers AJ, Matthay MA Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Lung volume quantified by MRI reflects extracellular-matrix deposition and altered pulmonary function in bleomycin models of fibrosis: Effects of SOM230.
Abstract Idiopathic pulmonary fibrosis is a progressive and lethal disease, characterized by loss of lung elasticity and alveolar surface area, secondary to alveolar epithelial cell injury, reactive inflammation, proliferation of fibroblasts and deposition of extracellular matrix. The effects of oropharyngeal aspiration of bleomycin in Sprague Dawley rats and C57BL/6 mice, as well as of intra-tracheal administration of ovalbumin to actively sensitized Brown Norway rats on total lung volume as assessed non-invasively by magnetic resonance imaging (MRI) were investigated here. Lung injury and volume were quantified u...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 11, 2014 Category: Cytology Authors: Egger C, Gérard C, Vidotto N, Accart N, Cannet C, Dunbar A, Tigani B, Piaia A, Jarai G, Jarman E, Schmid HA, Beckmann N Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide.
The objective of this study was to compare the short-term respiratory effects due to the inhalation of electronic and conventional tobacco cigarette-generated mainstream aerosols through the measurement of the exhaled nitric oxide (eNO). To this purpose, twenty-five smokers were asked to smoke a conventional cigarette and to vape an electronic cigarette (with and without nicotine), and an electronic cigarette without liquid (control session). Electronic and tobacco cigarette mainstream aerosols were characterized in terms of total particle number concentrations and size distributions. On the basis of the measured total par...
Source: Toxicology and Applied Pharmacology - April 11, 2014 Category: Toxicology Authors: Marini S, Buonanno G, Stabile L, Ficco G Tags: Toxicol Appl Pharmacol Source Type: research

Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues.
Abstract Defining the chronic cardiotoxic effects of drugs during preclinical screening is hindered by the relatively short lifetime of functional cardiac tissues in vitro, which are traditionally cultured on synthetic materials that do not recapitulate the cardiac microenvironment. Because collagen is the primary extracellular matrix protein in the heart, we hypothesized that micromolded gelatin hydrogel substrates tuned to mimic the elastic modulus of the heart would extend the lifetime of engineered cardiac tissues by better matching the native chemical and mechanical microenvironment. To measure tissue stress,...
Source: Biomaterials - April 11, 2014 Category: Materials Science Authors: McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK Tags: Biomaterials Source Type: research

A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.
In this study, we evaluated the systemic and local immunogenicity of a new double-adjuvanted influenza vaccine administered at the site of infection, the respiratory tract. This vaccine combines a plant-produced H1N1 influenza hemagglutinin antigen (HAC1), a silica nanoparticle-based (SiO2) drug delivery system and the mucosal adjuvant candidate bis-(3',5')-cyclic dimeric guanosine monophosphate (c-di-GMP). Mice were vaccinated by intratracheal route with HAC1/SiO2 or HAC1/c-di-GMP (single-adjuvanted vaccine) or HAC1/SiO2/c-di-GMP (double-adjuvanted vaccine) and evaluated for target-specific immune responses, such as hemag...
Source: Vaccine - April 11, 2014 Category: Allergy & Immunology Authors: Neuhaus V, Chichester JA, Ebensen T, Schwarz K, Hartman CE, Shoji Y, Guzmán CA, Yusibov V, Sewald K, Braun A Tags: Vaccine Source Type: research

Four-Dimensional Patient Dose Reconstruction for Scanned Ion Beam Therapy of Moving Liver Tumors
Conclusions: A considerable impact of interplay effects on the single-fraction CTV dose was found for most of the analyzed patients. However, due to the fractionated treatment, dose heterogeneities were substantially reduced for the total treatment dose. 4D treatment dose reconstruction for scanned ion beam therapy is technically feasible and may evolve into a valuable tool for dose assessment. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 10, 2014 Category: Radiology Authors: Daniel Richter, Nami Saito, Naved Chaudhri, Martin Härtig, Malte Ellerbrock, Oliver Jäkel, Stephanie E. Combs, Daniel Habermehl, Klaus Herfarth, Marco Durante, Christoph Bert Tags: Physics Contributions Source Type: research

Community‐acquired pneumonia in pediatric patients with acute neuromuscular respiratory failure: A microbiologic perspective
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 10, 2014 Category: Respiratory Medicine Authors: Jong‐Hau Hsu, Tai‐Heng Chen, Yuh‐Jyh Jong Tags: Response to Letter Source Type: research

Influenza viral vectors expressing the Brucella OMP16 or L7/L12 proteins as vaccines against B. abortus infection
Conclusion: Thus, influenza vectors expressing Brucella protective antigens can be developed as novel influenza vectored vaccine against B. abortus infection. (Source: Virology Journal)
Source: Virology Journal - April 10, 2014 Category: Virology Authors: Kaissar TabynovAbylai SansyzbayZhailaubay KydyrbayevBolat YespembetovSholpan RyskeldinovaNadezhda ZininaNurika AssanzhanovaKulaisan SultankulovaNurlan SandybayevBerik KhairullinIrina KuznetsovaBoris FerkoAndrej Egorov Source Type: research

Issue Information
(Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - April 10, 2014 Category: Infectious Diseases Tags: Issue Information Source Type: research

Frequent utilization of the emergency department for acute exacerbation of chronic obstructive pulmonary disease
Conclusions: In this large cohort study, we found that 29% had frequent ED visits for AECOPD and that lower socioeconomic status was significantly associated with a higher frequency of ED visits. Individuals with frequent ED visits for AECOPD accounted for a substantial amount of healthcare utilization and financial burden. (Source: Respiratory Research)
Source: Respiratory Research - April 10, 2014 Category: Respiratory Medicine Authors: Kohei HasegawaYusuke TsugawaChu-Lin TsaiDavid BrownCarlos Camargo Source Type: research

Sleeping position and responses to a carbon dioxide challenge in convalescent prematurely born infants studied post-term
Conclusions Convalescent, prematurely born infants studied post-term have a reduced respiratory drive, but not a lower ventilatory response to a CO2 challenge, in the prone compared to the supine position. (Source: Archives of Disease in Childhood - Fetal and Neonatal Edition)
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 10, 2014 Category: Perinatology & Neonatology Authors: Saiki, T., Milner, A. D., Hannam, S., Rafferty, G. F., Peacock, J. L., Greenough, A. Tags: Epidemiologic studies Original articles Source Type: research

Do children's upper respiratory tract infections benefit from probiotics?
DiscussionThe role of probiotics in gastrointestinal and allergic diseases has been largely assessed, but the number of studies performed so far in the field of respiratory tract infections is small, though some data show that probiotic administration might display clinical advantages. Probiotic strain identity and host genetic differences may account for differential modulation of immune responses by probiotics. Current laboratory and clinical data regarding the possibility of the role of probiotics on preventing the development of respiratory tract infections are contradictory, and are somewhat insufficient to recommend ...
Source: BMC Infectious Diseases - April 10, 2014 Category: Infectious Diseases Authors: Susanna EspositoDonato RiganteNicola Principi Source Type: research

A 10-year population-based nationwide descriptive analysis of pediatric emergency care
Conclusions: In Taiwan, 25% of individuals seeking emergency care are children, mostly aged 0-5 years old. Costs and disease patterns vary among different age groups. Preventive measures targeting all children should focus on respiratory and gastrointestinal diseases, but should target different diseases for different age groups to improve child health. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - April 10, 2014 Category: Pediatrics Authors: Mei-Jy JengYu-Sheng LeePei-Chen TsaoChia-Feng YangYu-Cheng LuoWen-Jue Soong Source Type: research

Physiological responses and energy cost of walking on the Gait Trainer with and without body weight support in subacute stroke patients
Conclusions: In PG, GT-BWS walking resulted in less cardiometabolic demand than overground walking. This suggests that GT-BWS walking training might be safer than overground walking training in subacute stroke patients. (Source: Journal of NeuroEngineering and Rehabilitation)
Source: Journal of NeuroEngineering and Rehabilitation - April 10, 2014 Category: Rehabilitation Authors: Anna DelussuGiovanni MoroneMarco IosaMaura BragoniMarco TraballesiStefano Paolucci Source Type: research

The Spatial Resolution of Epidemic Peaks
by Harriet L. Mills, Steven Riley The emergence of novel respiratory pathogens can challenge the capacity of key health care resources, such as intensive care units, that are constrained to serve only specific geographical populations. An ability to predict the magnitude and timing of peak incidence at the scale of a single large population would help to accurately assess the value of interventions designed to reduce that peak. However, current disease-dynamic theory does not provide a clear understanding of the relationship between: epidemic trajectories at the scale of interest (e.g. city); population mobility; and high...
Source: PLoS Computational Biology - April 10, 2014 Category: Biology Authors: Harriet L. Mills et al. Source Type: research

In utero cannabinoid exposure alters breathing and the response to hypoxia in newborn mice
In conclusion, the endocannabinoid pathway at birth seems to modulate breathing and protect the newborn against apnoeas. However, when exposed prenatally to an excess of cannabinoid, the breathing neuronal network in development seems to be modified, probably rendering the newborn more vulnerable in the face of an unstable environment. Cannabis is one of the most commonly used recreational drugs at ages highly correlated with potential pregnancies and long term effects on cognitive functions are clearly showed. We show that in utero exposure to cannabinoid modified both peripheral and central networks, which modulate the ...
Source: European Journal of Neuroscience - April 10, 2014 Category: Neuroscience Authors: Keda C. Tree, Maud Scotto di Perretolo, Julie Peyronnet, Florence Cayetanot Tags: Research Report Source Type: research

Autosomal-recessive cerebellar ataxia caused by a novel ADCK3 mutation that elongates the protein: clinical, genetic and biochemical characterisation
Conclusion This study highlights the importance of diagnosing ADCK3 mutations and the potential benefit of treatment for patients. The identification of this new mutation broadens the phenotypic spectrum associated with ADCK3 mutations and provides further understanding of their pathogenic mechanism. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - April 10, 2014 Category: Neurosurgery Authors: Liu, Y.-T., Hersheson, J., Plagnol, V., Fawcett, K., Duberley, K. E. C., Preza, E., Hargreaves, I. P., Chalasani, A., Laura, M., Wood, N. W., Reilly, M. M., Houlden, H. Tags: Open access, Genetics, Brain stem / cerebellum, Drugs: CNS (not psychiatric) Neurogenetics Source Type: research

Do children¿s upper respiratory tract infections benefit from probiotics?
DiscussionThe role of probiotics in gastrointestinal and allergic diseases has been largely assessed, but the number of studies performed so far in the field of respiratory tract infections is small, though some data show that probiotic administration might display clinical advantages. Probiotic strain identity and host genetic differences may account for differential modulation of immune responses by probiotics. Current laboratory and clinical data regarding the possibility of the role of probiotics on preventing the development of respiratory tract infections are contradictory, and are somewhat insufficient to recommend ...
Source: BMC Infectious Diseases - April 10, 2014 Category: Infectious Diseases Authors: Susanna EspositoDonato RiganteNicola Principi Source Type: research

Psychophysiological Responses to Overloading and Tapering Phases in Elite Young Soccer Players.
This study investigated the effect of a 2 week overloading training phase followed by a 2 week tapering phase on internal training load (ITL), salivary cortisol, stress tolerance, and upper respiratory tract infections symptoms (URTI) in 11 male young soccer players (16.0 ± 0.5 yrs). Ratings of perceived exertion (session-RPE) were taken after each training session (n=194) to determine ITL. Saliva sampling was conducted at the end of each week and cortisol concentration assessed by ELISA. DALDA and WURSS-21 questionnaires were administered every week to evaluate stress tolerance and severity of URTI respectively. The numb...
Source: Pediatric Exercise Science - April 10, 2014 Category: Pediatrics Authors: Freitas CG, Aoki MS, Franciscon CA, Arruda A FS, Carling C, Moreira A Tags: Pediatr Exerc Sci Source Type: research

Propofol is Associated with Favorable Outcomes Compared to Benzodiazepines in Ventilated ICU Patients.
Conclusions: In this large, propensity matched ICU population; patients treated with propofol had a reduced risk of mortality and had both and increased likelihood of earlier ICU discharge as well as earlier discontinuation of mechanical ventilation. PMID: 24720509 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 10, 2014 Category: Respiratory Medicine Authors: Lonardo NW, Mone MC, Nirula R, Kimball EJ, Ludwig K, Zhou X, Sauer BC, Nechodom K, Teng C, Barton RG Tags: Am J Respir Crit Care Med Source Type: research

Long term outcomes following development of new-onset atrial fibrillation during sepsis.
CONCLUSIONS: Most sepsis survivors with new-onset AF during sepsis have AF occur after discharge from the sepsis hospitalization, and have increased long-term risks for heart failure, ischemic stroke and death. Our findings may have implications for post-hospitalization surveillance of patients with new-onset AF during a sepsis hospitalization. PMID: 24723004 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Walkey AJ, Hammill BG, Curtis LH, Benjamin EJ Tags: Chest Source Type: research

Relationship of the SAME-TT2R2score to poor quality anticoagulation, stroke, clinically relevant bleeding and mortality in patients with atrial fibrillation.
CONCLUSION We demonstrate that the SAME-TT2R2 score was predictive for an increasing risk of stroke/TE, severe bleeding, major BARC bleeding and death, reflecting poor anticoagulation control (and labile INRs) on VKA amongst our patients with AF. PMID: 24722973 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L Tags: Chest Source Type: research

Detection of Fibroproliferation by Chest High Resolution Computed Tomography in Resolving Acute Respiratory Distress Syndrome.
CONCLUSIONS. In patients with ARDS, diminished lung compliance measured bedside was associated with radiologic fibroproliferation 14 days post diagnosis. Establishing factors that predispose to development of excessive fibroproliferation with subsequent confirmation by chest HRCT represents a promising strategy to identify ARDS patients at risk for poorer clinical outcomes. PMID: 24722949 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Burnham EL, Hyzy RC, Paine R, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ Tags: Chest Source Type: research

Adenovirus-specific immunoglobulin G maturation as a surrogate marker in acute exacerbations of COPD.
CONCLUSIONS: Delayed immunoglobulin avidity maturation, following COPD exacerbation, is associated with worse outcome. PMID: 24722914 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Boeck L, Gencay M, Roth M, Hirsch HH, Christ-Crain M, Mueller B, Tamm M, Stolz D Tags: Chest Source Type: research

Thrombosis Prophylaxis and Mortality Risk among Critically Ill Adults.
CONCLUSIONS: These findings support a recommendation for prophylactic anticoagulation in preference to mechanical device prophylaxis for critically ill adults that do not have a contraindication to anticoagulation. PMID: 24722879 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Lilly CM, Liu X, Badawi O, Franey CS, Zuckerman IH Tags: Chest Source Type: research

Exertional hypoxemia in stable COPD is common and predicted by circulating proadrenomedullin.
CONCLUSIONS: Exertional desaturation is common and associated with poorer clinical outcomes in COPD. Adrenomedullin improves prediction of exertional desaturation as compared to the use of FEV1%pred alone. PMID: 24722847 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - April 10, 2014 Category: Respiratory Medicine Authors: Stolz D, Boersma W, Blasi F, Louis R, Milenkovic B, Kostikas K, Aerts JG, Rohde G, Lacoma A, Rakic J, Boeck L, Castellotti P, Scherr A, Marin A, Hertel S, Giersdorf S, Torres A, Welte T, Tamm M Tags: Chest Source Type: research

Sphingomonas gimensis sp. nov., a novel Gram-negative bacterium isolated from abandoned lead-zinc ore mine.
Abstract A novel bacterial strain designated 9PNM-6(T) was isolated from an abandoned lead-zinc ore mine site in Meizhou, Guangdong Province, China. The isolate was found to be Gram-negative, rod-shaped, orange-pigmented, strictly aerobic, oxidase- and catalase-positive. Growth occurred at 0-4 % NaCl (w/v, optimum, 0 %), at pH 6.0-8.0 (optimum, pH 7.0) and at 15-32 °C (optimum, 28-30 °C). Phylogenetic analysis based on 16S rRNA gene sequence similarities showed that strain 9PNM-6(T) belongs to the genus Sphingomonas, with the highest sequence similarities with Sphingomonas jejuensis NBRC 107775(T) (99.7 %), ...
Source: Antonie van Leeuwenhoek - April 10, 2014 Category: Microbiology Authors: Feng GD, Yang SZ, Wang YH, Zhao GZ, Deng MR, Zhu HH Tags: Antonie Van Leeuwenhoek Source Type: research

The surface charge of liposomal adjuvants is decisive for their interactions with the Calu-3 and A549 airway epithelial cell culture models.
Abstract One of the main reasons for the unmet medical need for mucosal vaccines is the lack of safe and efficacious mucosal adjuvants. The cationic liposome-based adjuvant system composed of dimethyldioctadecylammonium (DDA) bromide and trehalose 6,6'-dibehenate (TDB) is a versatile adjuvant that has shown potential for mucosal vaccination via the airways. The purpose of this study was to investigate the importance of the liposomal surface charge on the interaction with lung epithelial cells. Thus, the cationic DDA in the liposomes was subjected to a step-wise replacement with the zwitterionic distearoylphosphatid...
Source: European Journal of Pharmaceutics and Biopharmaceutics - April 10, 2014 Category: Drugs & Pharmacology Authors: Ingvarsson PT, Rasmussen IS, Viaene M, Irlik PJ, Nielsen HM, Foged C Tags: Eur J Pharm Biopharm Source Type: research

Oxygen therapy: professional compliance with national guidelines.
Abstract One of the major causes of critical illness in the UK is the deterioration of respiratory function (British Thoracic Society (BTS), 2008). The administration of supplemental oxygen therapy, although often lifesaving, can also have serious consequences if performed inappropriately. A literature review was carried out to establish whether oxygen therapy was prescribed and administered in acute care in accordance with both national guidelines and local policy. Four common themes were identified from the literature: prescribing, monitoring, administration and equipment. The review suggests that an educational ...
Source: British Journal of Nursing - April 10, 2014 Category: Nursing Authors: Nippers I, Sutton A Tags: Br J Nurs Source Type: research

Neutrophil Dependence of Vascular Remodeling after Mycoplasma Infection of Mouse Airways.
Abstract Vascular remodeling is a feature of sustained inflammation in which capillaries enlarge and acquire the phenotype of venules specialized for plasma leakage and leukocyte recruitment. We sought to determine whether neutrophils are required for vascular remodeling in the respiratory tract by using Mycoplasma pulmonis infection as a model of sustained inflammation in mice. The time course of vascular remodeling coincided with the influx of neutrophils during the first few days after infection and peaked at day 5. Depletion of neutrophils with antibody RB6-8C5 or 1A8 reduced neutrophil influx and vascular remo...
Source: The American Journal of Pathology - April 10, 2014 Category: Pathology Authors: Baluk P, Phillips K, Yao LC, Adams A, Nitschké M, McDonald DM Tags: Am J Pathol Source Type: research

IRF-3, IRF-7, and IPS-1 Promote Host Defense against Acute Human Metapneumovirus Infection in Neonatal Mice.
Abstract Human metapneumovirus (hMPV) is a leading cause of respiratory tract disease in children and is associated with acute bronchiolitis, pneumonia, and asthma exacerbations, yet the mechanisms by which the host immune response to hMPV is regulated are poorly understood. By using gene-deleted neonatal mice, we examined the contributions of the innate receptor signaling molecules interferon (IFN)-β promoter stimulator 1 (IPS-1), IFN regulatory factor (IRF) 3, and IRF7. Viral load in the lungs was markedly greater in IPS-1(-/-) > IRF3/7(-/-) > IRF3(-/-), but not IRF7(-/-), mice compared with wild-type ...
Source: The American Journal of Pathology - April 10, 2014 Category: Pathology Authors: Spann KM, Loh Z, Lynch JP, Ullah A, Zhang V, Baturcam E, Werder RB, Khajornjiraphan N, Rudd P, Loo YM, Suhrbier A, Gale M, Upham JW, Phipps S Tags: Am J Pathol Source Type: research

Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice.
Abstract X-linked myotubular myopathy is a congenital myopathy caused by deficiency of myotubularin. Patients often present with severe perinatal weakness, requiring mechanical ventilation to prevent death from respiratory failure. We recently reported that an activin receptor type IIB inhibitor produced hypertrophy of type 2b myofibers and modest increases of strength and life span in the severely myopathic Mtm1δ4 mouse model of X-linked myotubular myopathy. We have now performed a similar study in the less severely symptomatic Mtm1 p.R69C mouse in hopes of finding greater treatment efficacy. Activin receptor typ...
Source: The American Journal of Pathology - April 10, 2014 Category: Pathology Authors: Lawlor MW, Viola MG, Meng H, Edelstein RV, Liu F, Yan K, Luna EJ, Lerch-Gaggl A, Hoffmann RG, Pierson CR, Buj-Bello A, Lachey JL, Pearsall S, Yang L, Hillard CJ, Beggs AH Tags: Am J Pathol Source Type: research

The human health effects of Florida Red Tide (FRT) blooms: An expanded analysis.
Abstract Human respiratory and digestive illnesses can be caused by exposures to brevetoxins from blooms of the marine alga Karenia brevis, also known as Florida red tide (FRT). K. brevis requires macro-nutrients to grow; although the sources of these nutrients have not been resolved completely, they are thought to originate both naturally and anthropogenically. The latter sources comprise atmospheric depositions, industrial effluents, land runoffs, or submerged groundwater discharges. To date, there has been only limited research on the extent of human health risks and economic impacts due to FRT. We hypothesized ...
Source: Environment International - April 10, 2014 Category: Environmental Health Authors: Hoagland P, Jin D, Beet A, Kirkpatrick B, Reich A, Ullmann S, Fleming LE, Kirkpatrick G Tags: Environ Int Source Type: research

Acute Intermittent Porphyria Causes Hepatic Mitochondrial Energetic Failure In A Mouse Model.
Abstract Acute intermittent porphyria (AIP), an inherited hepatic disorder, is due to a defect of hydroxymethylbilane synthase (HMBS), an enzyme involved in heme biosynthesis. AIP is characterized by recurrent, life-threatening attacks at least partly due to the increased hepatic production of 5-aminolaevulinic acid (ALA). Both the mitochondrial enzyme, ALA synthase (ALAS) 1, involved in the first step of heme biosynthesis, which is closely linked to mitochondrial bioenergetic pathways, and the promise of an ALAS1 siRNA hepatic therapy in humans, led us to investigate hepatic energetic metabolism in Hmbs KO mice tr...
Source: The International Journal of Biochemistry and Cell Biology - April 10, 2014 Category: Biochemistry Authors: Homedan C, Laafi J, Schmitt C, Gueguen N, Lefebvre T, Karim Z, Desquiret-Dumas V, Wetterwald C, Deybach JC, Gouya L, Puy H, Reynier P, Malthièry Y Tags: Int J Biochem Cell Biol Source Type: research

RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction
Respiratory syncytial virus (RSV) infection is the major cause of bronchiolitis in young children. The factors that contribute to the increased propensity of RSV-induced distal airway disease compared with other commonly encountered respiratory viruses remain unclear. Here, we identified the RSV-encoded nonstructural 2 (NS2) protein as a viral genetic determinant for initiating RSV-induced distal airway obstruction. Infection of human cartilaginous airway epithelium (HAE) and a hamster model of disease with recombinant respiratory viruses revealed that NS2 promotes shedding of infected epithelial cells, resulting in two co...
Source: Journal of Clinical Investigation - April 9, 2014 Category: Biomedical Science Authors: Rachael M. Liesman, Ursula J. Buchholz, Cindy L. Luongo, Lijuan Yang, Alan D. Proia, John P. DeVincenzo, Peter L. Collins, Raymond J. Pickles Source Type: research

Analysis of factors affecting rehospitalization of patients with chronic kidney disease after educational hospitalization
Kose E, An T, Kikkawa A, Matsumoto Y, Hayashi H (Source: International Journal of COPD)
Source: International Journal of COPD - April 9, 2014 Category: Respiratory Medicine Source Type: research

Innate immune response to a H3N2 subtype swine influenza virus in newborn porcine trachea cells, alveolar macrophages, and precision-cut lung slices
Viral respiratory diseases remain of major importance in swine breeding units. Swine influenza virus (SIV) is one of the main known contributors to infectious respiratory diseases. The innate immune response to swine influenza viruses has been assessed in many previous studies. However most of these studies were carried out in a single-cell population or directly in the live animal, in all its complexity. In the current study we report the use of a trachea epithelial cell line (newborn pig trachea cells - NPTr) in comparison with alveolar macrophages and lung slices for the characterization of innate immune response to an ...
Source: BioMed Central - April 9, 2014 Category: Journals (General) Authors: Mario Delgado-OrtegaSandrine MeloDarsaniya PunyadarsaniyaChristelle RaméMichel OlivierDenis SoubieuxDaniel MarcGaëlle SimonGeorg HerrlerMustapha BerriJoëlle DupontFrançois Meurens Source Type: research

Transient vascular and long-term alveolar deficits following a hyperoxic injury to neonatal mouse lung
Conclusions: This study suggests that administration of high oxygen to underdeveloped lungs has a transient reductive effect on secondary septal number and pulmonary vascularization and a significant long-term reduction in alveolarization persisting into adulthood. This model can be used for future research of premature lung disease therapies in humans, addressing these short term septal and vascular and long term alveolar deficits, specifically relating to injury by hyperoxia. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - April 9, 2014 Category: Respiratory Medicine Authors: Alexandra FirsovaTimothy ColeRichard Mollard Source Type: research