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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Tobacco and tuberculosis: could we improve tuberculosis outcomes by helping patients to stop smoking?
PMID: 25726531 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - March 1, 2015 Category: Respiratory Medicine Authors: Zellweger JP, Cattamanchi A, Sotgiu G Tags: Eur Respir J Source Type: research

Untreatable tuberculosis: is surgery the answer?
PMID: 25726530 [PubMed - in process] (Source: Respiratory Care)
Source: Respiratory Care - March 1, 2015 Category: Respiratory Medicine Authors: Dara M, Sotgiu G, Zaleskis R, Migliori GB Tags: Eur Respir J Source Type: research

Variation in Emergency Department Admission Rates in US Children’s Hospitals
There is a wide variation in hospital admissions for common pediatric illnesses. This retrospective, cross-sectional study used information collected from US children’s hospitals to determine the differences in hospital-level admissions, defined as inpatient or observation admission, for common pediatric illnesses. Using the All Patient Refined Diagnosis Related Grouping (APR-DRG) system, the authors identified the common admission diagnoses as asthma, cellulitis/skin infection, bronchiolitis/respiratory syncytial virus (RSV) pneumonia, pneumonia not elsewhere characterized (NEC), kidney/urinary tract infection, seizure,...
Source: The Journal of Emergency Medicine - March 1, 2015 Category: Emergency Medicine Authors: Cara Bergamo Tags: Abstract Source Type: research

Investigation of the multifaceted iron acquisition strategies of Burkholderia cenocepacia.
Abstract Burkholderia cenocepacia is a bacterial pathogen which causes severe respiratory infections in cystic fibrosis (CF). These studies were aimed at gaining an insight into the iron acquisition strategies of B. cenocepacia. In iron restricted conditions, genes associated with the synthesis and utilisation of ornibactin (pvdA, orbA, orb F) were significantly upregulated compared to the expression of pyochelin associated genes (pchD, fptA). In the absence of alternative iron sources, B. cenocepacia J2315 and 715j utilised ferritin and haemin, but not transferrin or lactoferrin for growth. Significantly, mutants ...
Source: Biometals - March 1, 2015 Category: Biochemistry Authors: Tyrrell J, Whelan N, Wright C, Sá-Correia I, McClean S, Thomas M, Callaghan M Tags: Biometals Source Type: research

Year in review 2014: Lung cancer, pleural diseases, respiratory infections and tuberculosis, bronchoscopic intervention and imaging
(Source: Respirology)
Source: Respirology - March 1, 2015 Category: Respiratory Medicine Authors: Kazuhisa Takahashi, José M Porcel, Pyng Lee, Chi Chiu Leung Tags: Year in Review Source Type: research

The natural history of pulmonary function in Duchenne muscular dystrophy
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 1, 2015 Category: Respiratory Medicine Authors: Jonathan D. Finder Tags: Editorial Source Type: research

Flavobacterium shanxiense sp. nov., Isolated from Soil.
Abstract Strain YF-2(T), a Gram-staining-negative, non-motile, non-spore-forming, light-yellow-pigmented bacterium, was isolated from soil samples collected in the city of Yuncheng, Shanxi province of China. Strain YF-2(T) grew over a temperature range of 25-37 °C, at pH 5.0-8.0 and with 0-5 % (w/v) NaCl. Phylogenetic analysis based on sequence of the 16S rRNA gene showed that strain YF-2(T) was closely related to strains Flavobacterium akiainvivens CIP 110358(T) and Flavobacterium hauense KCTC 32147(T) with 95.99 and 95.92 % sequence similarity, respectively. The dominant fatty acids of strain YF-2(T) were Sum...
Source: Current Microbiology - March 1, 2015 Category: Microbiology Authors: Yang F, Liu HM, Zhang R, Chen DB, Wang X, Yan X, Hong Q, Li SP Tags: Curr Microbiol Source Type: research

Aerosol‐Phase Activity of Iodine Captured from a Triiodide Resin Filter on Fine Particles Containing an Infectious Virus
ConclusionsThe results support the mechanism of near‐contact capture earlier proposed; however, the disinfection chemistry in the aerosol phase is very slow on the time scale of inhalation. Significance and Impact of StudyThis study shows that disinfection by filter‐bound iodine in the aerosol phase is too slow to be clinically significant in individual respiratory protection, but that it might be of benefit to limit airborne transmission of infections in enclosed areas.This article is protected by copyright. All rights reserved. (Source: Journal of Applied Microbiology)
Source: Journal of Applied Microbiology - March 1, 2015 Category: Microbiology Authors: Brian K. Heimbuch, Delbert A. Harnish, Charles Balzli, April Lumley, Kimberly Kinney, Joseph D. Wander Tags: Original Article Source Type: research

Naturally occurring bactericidal antibodies specific for Haemophilus influenzae Lipooligosaccharide are present in healthy adult individuals.
Abstract Nontypeable Haemophilus influenzae (NTHi), a typical mucosal pathogen largely responsible for respiratory infections and pediatric otitis media, has been increasingly recognized as a significant cause of invasive disease, especially in immunocompromised individuals. Lipooligosaccharide (LOS) is a conserved molecule with an important role in H. influenzae virulence and immune evasion, and it may be considered as a vaccine candidate. However, abilities of H. influenzae LOS to induce protective immune response are poorly understood. The goal of this study was to determine whether antibodies against LOS isolat...
Source: Vaccine - March 1, 2015 Category: Allergy & Immunology Authors: Choi J, Nix EB, Gaultier GN, Cox AD, McCready W, Ulanova M Tags: Vaccine Source Type: research

The effect of crude ethanolic extract of Diospyros mespiliformis (Ebenaceae) on the clinicopathological parameters of Yankasa sheep experimentally infected with Haemonchus contortus
Abstract The clinicopathological parameters of 25 Yankasa sheep of both sexes weighing between 10 and 23 kg, aged 6–12 months, were evaluated under experimental conditions following infection with Haemonchus contortus. Clinical parameters (temperature, respiratory rate, pulse rate, faecal egg count and body weight) were evaluated before and after infection, as well as before and after treatment. Also, gross and histopathological changes were determined. Changes in body weight, temperature, pulse rate and respiratory rate of the experimental animals were not statistically significant (P > 0.05), while t...
Source: Comparative Clinical Pathology - March 1, 2015 Category: Pathology Source Type: research

Inflammatory markers and mortality among US adults with obstructive lung function
ConclusionsAn index of elevated inflammatory markers predicted all‐cause mortality among adults with OLF. (Source: Respirology)
Source: Respirology - March 1, 2015 Category: Respiratory Medicine Authors: Earl S. Ford, Timothy J. Cunningham, David M. Mannino Tags: Original Article Source Type: research

Heterogeneity of lower airway inflammation in children with severe‐persistent asthma
ConclusionsTo our knowledge, ours is one of few studies to systematically investigate the pattern of lower airway inflammation in children with severe‐persistent asthma. Our results differ from a recent investigation in children, showing more heterogeneity and a greater proportion of neutrophilic inflammation. Further investigation is required to determine whether specific inflammatory patterns are associated with specific etiologies, and whether individualized therapy is warranted. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - March 1, 2015 Category: Respiratory Medicine Authors: Caitlin E. O'Brien, Kalliope Tsirilakis, Maria Teresa Santiago, David L. Goldman, Alfin G. Vicencio Tags: Original Article: Asthma Source Type: research

Validation of a new adhesive coating solution: comparative study of carbon tetrachloride and diethyl ether
In this study, we examined the impaction efficiency of CCl4 and diethyl ether ((C2H5)2O) over several weeks. The results show that there is no significant difference between the two silicone solvents and that diethyl ether may replace CCl4 for coating the tape. (Source: Aerobiologia)
Source: Aerobiologia - February 28, 2015 Category: Environmental Health Source Type: research

Methylene Blue for Burn-Induced Vasoplegia: Case Report and Review of Literature
We report the use of a single dose of methylene blue in a patient with burn-induced vasoplegia refractory to fluids, vasopressors, and steroids. Administration of methylene blue allowed for cessation of epinephrine infusion within 2 hours of administration, and reduction in excessive fluid resuscitation. The patient’s clinical course continued for 2 months and was complicated by severe acute respiratory distress syndrome, pneumonia, septic shock, poor skin graft adherence, renal failure requiring continuous renal replacement therapy, cutaneous mucormycosis, and ultimately, withdrawal of care and death. Despite the eventu...
Source: Journal of Burn Care and Research - February 28, 2015 Category: Rehabilitation Tags: Case Report Source Type: research

MR Imaging of the Coronary Vasculature
The characteristics of coronary artery disease are gradual thickening of the coronary walls and narrowing of the vascular lumen by the buildup of atherosclerosis plaques. These morphologic changes can be noninvasively detected by coronary magnetic resonance (MR) imaging/MR angiography (MRA). In addition, functional changes, such as coronary wall distensibility and flow changes, may also be evaluated with MR imaging. However, the application of current MR imaging/MRA techniques is limited in clinical practice because of several adverse technical and physiologic factors, such as cardiac and respiratory motion. Many technical...
Source: Radiologic Clinics of North America - February 28, 2015 Category: Radiology Authors: Kai Lin, James C. Carr Source Type: research

Spinal Osteotomy Techniques in Management of Severe Pediatric Spinal Deformity and Analysis of Postoperative Complications
Conclusion. There was no significant difference in coronal correction among these 3 techniques, whereas, the average corrections in the sagittal plane were progressively higher from single SPO to 2 SPOs or PSO to 3 SPOs or VCR. Preoperative respiratory insufficiency and rigidity of the spinal deformity are associated with a high complication rate. Level of Evidence: 3 (Source: Spine)
Source: Spine - February 28, 2015 Category: Orthopaedics Tags: Deformity Source Type: research

Anti-inflammatory effects of atorvastatin treatment in chronic obstructive pulmonary disease. A controlled pilot study.
Authors: Mroz RM, Lisowski P, Tycinska A, Bierla J, Trzeciak PZ, Minarowski L, Milewski R, Lisowska A, Boros P, Sobkowicz B, Duszewska AM, Chyczewska E, Musial WJ, MacNee W Abstract UNLABELLED: Observational studies have suggested that statins may have beneficial effects on outcomes in chronic obstructive pulmonary disease (COPD) patients. These effects may be mediated through an anti-inflammatory effect of statins. The purpose of this pilot-study was to determine whether statins have an anti-inflammatory effect on the lungs of COPD patients. We conducted randomized, controlled, parallel group pilot-study to compar...
Source: Journal of Physiology and Pharmacology - February 28, 2015 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research

Identification of NDUFAF1 in mediating K-Ras induced mitochondrial dysfunction by a proteomic screening approach.
Authors: Wang P, Song M, Zeng ZL, Zhu CF, Lu WH, Yang J, Ma MZ, Huang AM, Hu Y, Huang P Abstract Increase in aerobic glycolysis and mitochondrial dysfunction are important biochemical features observed in human cancers. Recent studies suggest oncogenic K-Ras can cause suppression of mitochondrial respiration and up-regulation of glycolytic activity through a yet unknown mechanism. Here we employed proteomic approach and used a K-RasG12V inducible cell system to investigate the impact of oncogenic K-Ras on mitochondria and cell metabolism. Mitochondria isolated from cells before and after K-Ras induction were subjec...
Source: Oncotarget - February 28, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Sudden unexpected death in epilepsy: some approaches to prevent it.
Authors: Verma A, Kumar A Abstract Mortality because of epilepsy is a major concern worldwide. People with epilepsy have a two to three times increased risk of death in comparison with the general population. Sudden unexplained death in epilepsy is a mysterious, rare condition, in which typically young or middle-aged people with epilepsy die without a clearly defined cause. Several different mechanisms probably exist, and most research has focused on seizure-related respiratory depression, cardiac arrhythmia, cerebral depression, and autonomic dysfunction. In recent years, some significant risk factors have been re...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - February 28, 2015 Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research

A phase I trial and viral clearance study of reovirus (Reolysin) in children with relapsed or refractory extra‐cranial solid tumors: A Children's Oncology Group Phase I Consortium report
ConclusionsReolysin at a dose of 5 × 108 TCID50/kg daily for 5 days was well tolerated in children alone and in combination with oral cyclophosphamide. Virus was cleared rapidly from the serum and shedding in stool and saliva was not detectable. Pediatr Blood Cancer © 2015 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 28, 2015 Category: Cancer & Oncology Authors: E . Anders Kolb, Valerie Sampson, Deborah Stabley, Alexa Walter, Katia Sol‐Church, Timothy Cripe, Pooja Hingorani, Charlotte Hsieh Ahern, Brenda J. Weigel, James Zwiebel, Susan M. Blaney Tags: Research Article Source Type: research

eAMI: A Qualitative Quantification of Periodic Breathing Based on Amplitude of Oscillations
Conclusions:In terms of quantification and temporal resolution, the eAMI is able to estimate the strength of periodic breathing and the underlying loop gain at any given time within a record. The impaired prognosis associated with periodic breathing makes its automated detection and early diagnosis of clinical relevance.Citation:Fernandez Tellez H, Pattyn N, Mairesse O, Dolenc-Groselj L, Eiken O, Mekjavic IB, Migeotte PF, Macdonald-Nethercott E, Meeusen R, Neyt X. eAMI: a qualitative quantification of periodic breathing based on amplitude of oscillations. SLEEP 2015;38(3):381–389. (Source: Sleep)
Source: Sleep - February 28, 2015 Category: Sleep Medicine Source Type: research

Cost-effectiveness of Out-of-Hospital Continuous Positive Airway Pressure for Acute Respiratory Failure
Conclusion The cost-effectiveness of out-of-hospital CPAP is uncertain. The incidence of patients eligible for out-of-hospital CPAP appears to be the key determinant of cost-effectiveness. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - February 28, 2015 Category: Emergency Medicine Source Type: research

Early versus late extubation after surfactant replacement therapy for respiratory distress syndrome
Conclusion Early administration of surfactants is associated with early extubation. Patients who were extubated early (most of them had an early administration of surfactants) had a lower chance for re-intubation, less duration of total oxygen administration and less hospital stay. (Source: Egyptian Pediatric Association Gazette)
Source: Egyptian Pediatric Association Gazette - February 28, 2015 Category: Pediatrics Source Type: research

Improvement of Renal Diffusion-Weighted Magnetic Resonance Imaging with Readout-Segmented Echo-Planar Imaging at 3T
To assess the feasibility of a respiratory-gated implementation of readout-segmented SE-EPI (RESOLVE) for renal diffusion-weighted imaging (DWI) by comparison with single-shot SE-EPI (ss-EPI) in a phantom, healthy volunteers and chronic kidney disease (CKD) patients. (Source: Magnetic Resonance Imaging)
Source: Magnetic Resonance Imaging - February 28, 2015 Category: Radiology Authors: I. Friedli, L.A. Crowe, M. Viallon, D.A. Porter, P.Y. Martin, S. de Seigneux, J.-P. Vallée Source Type: research

Lead selection and characterization of antitubercular compounds using the nested chemical library
Discovering new drugs to treat tuberculosis more efficiently and to overcome multidrug resistance is a world health priority. To find novel antitubercular agents several approaches have been used in various institutions worldwide, including target-based approaches against several validated mycobacterial enzymes and phenotypic screens. We screened more than 17,000 compounds from Vichem's Nested Chemical Library™ using an integrated strategy involving whole cell-based assays with Corynebacterium glutamicum and Mycobacterium tuberculosis, and target-based assays with protein kinases PknA, PknB and PknG as well as other targ...
Source: Tuberculosis - February 28, 2015 Category: Respiratory Medicine Authors: Anna Sipos, János Pató, Rita Székely, Ruben C. Hartkoorn, László Kékesi, László Őrfi, Csaba Szántai-Kis, Katarína Mikušová, Zuzana Svetlíková, Jana Korduláková, Valakunja Nagaraja, Adwait Anand Godbole, Natassja Bush, Frédéric Collin, A Source Type: research

Childhood BCG vaccination does not influence control of growth by human bronchoalveolar lavage cells
Abstract (Source: Tuberculosis)
Source: Tuberculosis - February 28, 2015 Category: Respiratory Medicine Authors: Christian Herzmann, Giovanni Sotgiu, Tom Schaberg, Martin Ernst, Steffen Stenger, Christoph Lange, the TB or not TB Consortium Tags: Model Systems Source Type: research

Toll-like receptor 1 variations influence susceptibility and immune response to
Tuberculosis (TB), a disease caused by Mycobacterium tuberculosis (MTB) infection, is still a global public health problem. TB susceptibility varies greatly in infected individuals, and mycobacterial recognition by the innate immune system likely affects disease course and outcome. This research describes a single nucleotide polymorphism in the Toll-like receptor (TLR) 1 gene that functionally alters the innate immune response to MTB and is associated with TB susceptibility in India. (Source: Tuberculosis)
Source: Tuberculosis - February 28, 2015 Category: Respiratory Medicine Authors: Nickel Dittrich, Luis C. Berrocal-Almanza, Shruthi Thada, Surabhi Goyal, Hortense Slevogt, Gaddam Sumanlatha, Abid Hussain, Saubashya Sur, Sanne Burkert, Djin-Ye Oh, Vijayalakshmi Valluri, Ralf R. Schumann, Melanie L. Conrad Tags: Host Genetics of Susceptibility Source Type: research

Relationship between energy expenditure, Physical Activity and weight loss during CPAP treatment in obese osa subjects
Increased energy expenditure (EE) has been reported in patients with obstructive sleep apnea (OSA). It has been postulated that CPAP treatment may induce weight reduction in obese patients, even if it has not been confirmed by recent studies.In the present study we investigated the effect of OSA on EE and the effect of CPAP on body weight and physical activity. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - February 28, 2015 Category: Respiratory Medicine Authors: Michele Bamberga, Maurizio Rizzi, Felice Gadaleta, Attilio Grechi, Renata Baiardini, Francesco Fanfulla Source Type: research

Comparative , and analyses of a CFTR splicing mutation: Importance of functional studies to establish disease liability of mutations
The Cystic Fibrosis p.Ile1234Val missense mutation actually creates a new dual splicing site possibly used either as a new acceptor or donor.Here, we aimed to test the accuracy of in silico predictions by comparing them with in vitro and ex vivo functional analyses of this mutation for an accurate CF diagnosis/prognosis.To this end, we applied a new in vitro strategy using a CFTR mini-gene which includes the complete CFTR coding sequence plus intron 22 (short version) which allows the assessment of alternatively spliced mRNA levels as well as the properties of the resulting abnormal CFTR protein regarding processing, intra...
Source: Journal of Cystic Fibrosis - February 28, 2015 Category: Respiratory Medicine Authors: Anabela S. Ramalho, Luka A. Clarke, Marisa Sousa, Verónica Felicio, Celeste Barreto, Carlos Lopes, Margarida D. Amaral Tags: Original Article Source Type: research

Diagnostic value of cyfra 21-1 and carcinoembryonic antigen in differentiation between benign and malignant pleural effusion
Conclusion Measurement of cyfra 21-1 and CEA in serum and pleural fluid is helpful in differentiation between benign and malignant pleural effusions. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - February 28, 2015 Category: Respiratory Medicine Source Type: research

Strain variation in the adaptation of C57Bl6 and BALBc mice to chronic hypobaric hypoxia
Publication date: Available online 31 January 2015 Source:Physiology & Behavior Author(s): Nathan Cramer , Xiufen Xu , Christine Christensen , Alexis Bierman , Clarke Tankersley , Zygmunt Galdzicki The interplay of environmental and genetic factors may lead to a spectrum of physiological and behavioral outcomes. How environmental stress factors interact with the diverse mouse genomes is still poorly understood and elucidating the underlying interactions requires specific stress models that can target integrated physiological systems. Here, we employ behavioral tests and whole-body plethysmography to examine the e...
Source: Physiology and Behavior - February 28, 2015 Category: Physiology Source Type: research

Cost-Minimization Analysis of Imipenem/Cilastatin versus Meropenem in Moderate to Severe Infections at a tertiary care hospital in Saudi Arabia
Conclusion This study has shown that while acquisition costs of IC at a dose of 500mg q6h may be lower than for MEM 1 gram q8h, mean total costs per day were not significantly different between IC and MEM, indicating that medicine costs are only a small element of the overall costs of managing moderate to severe infections. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - February 28, 2015 Category: Drugs & Pharmacology Source Type: research

Neonatal Outcomes after Oral Administration of Antenatal Corticosteroid: A Case Report
Publication date: Available online 27 February 2015 Source:Saudi Pharmaceutical Journal Author(s): Doua AlSaad , Palli Valapila Abdulrouf , Hussain Parappil , Asma Tarannum , Binny Thomas The use of antenatal corticosteroids is associated with reduction in morbidity and mortality rates in preterm delivery. A 34 year-old pregnant woman, gravida 2 para1, was planned for elective cesarean section at 36 weeks of gestation as ultrasound study showed intrauterine growth retardation. She has idiopathic thrombocytopenia and anemia, with suspected hypoplastic anemia. Due to mother’s low platelet count, antenatal intramuscular c...
Source: Saudi Pharmaceutical Journal - February 28, 2015 Category: Drugs & Pharmacology Source Type: research

Predictors of Unfavorable Thermal Outcome During Newborn Emergency Retrievals
Conclusion Abnormal temperature at the start of the retrieval, very low transport weight, and respiratory support were strong predictors of unfavorable thermal outcome during neonatal emergency transports. (Source: Air Medical Journal)
Source: Air Medical Journal - February 28, 2015 Category: Emergency Medicine Source Type: research

A Senile Man With Cystic Lesion of Liver and Biliary Obstruction
Question: An 83-year-old man presented with fever, biliary pain, and eosinophilia for 2 weeks. During admission in our hospital, the vital signs included: temperature 38.5°C, pulse 90 beats/min, respiratory rate 20 breaths/min, and blood pressure 140/85 mm Hg. On physical examination, the patient had tenderness in right upper quadrant and mild jaundice. (Source: Gastroenterology)
Source: Gastroenterology - February 28, 2015 Category: Gastroenterology Authors: Abdol Rahim Masjedizadeh, Pezhman Alavinejad, Ahmad Hormati Tags: Electronic Clinical Challenges and Images in GI Source Type: research

Gait mechanics in patients with chronic obstructive pulmonary disease
The objective of this study was to determine the presence of biomechanical gait abnormalities in COPD patients compared to healthy controls while well rested and without rest. Methods: Patients with COPD (N = 17) and aged-matched, healthy controls (N = 21) walked at their self-selected pace down a 10-meter walkway while biomechanical gait variables were collected. A one-minute rest was given between each of the five collected trials to prevent tiredness (REST condition). Patients with COPD then walked at a self-selected pace on a treadmill until the onset of self-reported breathlessness or leg tiredness. Subjects i...
Source: Respiratory Research - February 28, 2015 Category: Respiratory Medicine Authors: Jennifer YentesKendra SchmidDaniel BlankeDebra RombergerStephen RennardNicholas Stergiou Source Type: research

Laryngomalacia: Review and Summary of Current Clinical Practice in 2015
Laryngomalacia is the most common cause of stridor in neonates and infants. Associated feeding difficulties are present in approximately half of the children. A definitive diagnosis can generally be made with flexible fiberoptic laryngoscopy. The disorder is most often self-limited with resolution of symptoms within the first 24 months of life, and the majority of children can thus be managed conservatively. The approximately 5%-20% of children with severe or refractory disease may require more aggressive intervention, most commonly in the form of trans-oral supraglottoplasty. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - February 28, 2015 Category: Respiratory Medicine Authors: Marc C. Thorne, Susan L. Garetz Source Type: research

Reduced risk of nontuberculous mycobacteria in cystic fibrosis adults receiving long-term azithromycin
Azithromycin reduces exacerbations in cystic fibrosis (CF) patients. Our aim was to investigate its association with nontuberculous mycobacteria isolation and macrolide susceptibility. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - February 28, 2015 Category: Respiratory Medicine Authors: Nathalie Coolen, Philippe Morand, Clémence Martin, Dominique Hubert, Reem Kanaan, Jeanne Chapron, Isabelle Honoré, Daniel Dusser, Etienne Audureau, Nicolas Veziris, Pierre-Régis Burgel Tags: Original Article Source Type: research

Cystic fibrosis microbiology: Advances in antimicrobial therapy
Much of the improvement in the survival of individuals with cystic fibrosis (CF) is due to advancements in antimicrobial treatments. New aerosolized antibiotic formulations have recently been introduced (such as inhaled aztreonam), and others are in development (inhaled levofloxacin and liposomal amikacin). Licensed dry powder formulations include tobramycin inhalation powder and dry powder colistimethate (available in Europe). Although inhaled antibiotics have the advantage of being able to deliver high intrapulmonary concentrations of drug, antimicrobial resistance can still develop and is a concern in CF. (Source: Journ...
Source: Journal of Cystic Fibrosis - February 28, 2015 Category: Respiratory Medicine Authors: Valerie Waters, Alan Smyth Tags: Review Source Type: research

As part of the March issue, the European Respiratory Journal presents the 51st in its series of podcasts, in which chief editor Marc Humbert leads the discussion of recent articles published in the ERJ. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 28, 2015 Category: Respiratory Medicine Tags: Electronic Resources Source Type: research

Untreatable tuberculosis: is surgery the answer?
According to the 2014 World Health Organization (WHO) Global Report, tuberculosis (TB) continues to be the most important infectious disease in terms of incidence and mortality, along with HIV/AIDS: 9 million new cases and 1.5 million deaths are estimated to have occurred in 2013 [1]. (Source: European Respiratory Journal)
Source: European Respiratory Journal - February 28, 2015 Category: Respiratory Medicine Authors: Dara, M., Sotgiu, G., Zaleskis, R., Migliori, G. B. Tags: Respiratory infections and tuberculosis Editorials Source Type: research