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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Short-term glutamine supplementation decreases lung inflammation and the receptor for advanced glycation end-products expression in direct acute lung injury in mice
Conclusions: These results suggest that the benefit of dietary GLN may be partly contributed to an inhibitory effect on RAGE expression and pro-inflammatory cytokines production at an early stage in direct acid and LPS-induced ALI in mice. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - July 15, 2014 Category: Respiratory Medicine Authors: Yin-Ching ChuangHuey-Mei ShawChi-Chung ChenHe-Jia PanWei-Chih LaiHui-Ling Huang Source Type: research

Development of antibiotic treatment algorithms based on local ecology and respiratory surveillance cultures to restrict the use of broad-spectrum antimicrobial drugs in the treatment of hospital-acquired pneumonia in the intensive care unit: a retrospective analysis
Using a surveillance culture-based algorithm could reduce the use of broad-spectrum antibiotics and may be preferable when implementing new stewardship programs. (Source: Critical Care)
Source: Critical Care - July 15, 2014 Category: Intensive Care Authors: Liesbet De BusLies SaerensBram GadeyneJerina BoelensGeert ClaeysJan De WaeleDominique BenoitJohan DecruyenaerePieter Depuydt Source Type: research

A case of fixed drug eruption secondary to quinine in tonic water presenting to a sexual health clinic
We report a case of FDE with oral and genital lesions presenting to a sexual health clinic due to quinine contained in tonic water. (Source: Sexually Transmitted Infections)
Source: Sexually Transmitted Infections - July 15, 2014 Category: Sexual Medicine Authors: Lonsdale-Eccles, E., Wallett, A., Ward, A. M. Tags: Drugs: infectious diseases, Respiratory medicine, Dermatology, Occupational and environmental medicine Clinical Source Type: research

Effect of Glycemic Control on Nocturnal Arterial Oxygen Saturation. A case‐control study in Type 2 Diabetic patients
ConclusionsGlycemic control improvement significantly reduces the increased number of nocturnal oxygen desaturations that exist in type 2 diabetes. Although the mechanisms are not yet fully understood, the rapid effect without changes in body weight suggests a central mechanism involving respiratory center output. (Source: Journal of Diabetes)
Source: Journal of Diabetes - July 15, 2014 Category: Endocrinology Authors: Albert Lecube, Andreea Ciudin, Gabriel Sampol, Silvia Valladares, Cristina Hernández, Rafael Simó Tags: Original Article Source Type: research

Galen and the beginnings of Western physiology
Galen (129–c. 216 AD) was a key figure in the early development of Western physiology. His teachings incorporated much of the ancient Greek traditions including the work of Hippocrates and Aristotle. Galen himself was a well-educated Greco-Roman physician and physiologist who at one time was a physician to the gladiators in Pergamon. Later he moved to Rome, where he was associated with the Roman emperors Marcus Aurelius and Lucius Verus. The Galenical school was responsible for voluminous writings, many of which are still extant. One emphasis was on the humors of the body, which were believed to be important in disea...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: West, J. B. Tags: PERSPECTIVES Source Type: research

The polymorphic and contradictory aspects of intermittent hypoxia
Intermittent hypoxia (IH) has been extensively studied during the last decade, primarily as a surrogate model of sleep apnea. However, IH is a much more pervasive phenomenon in human disease, is viewed as a potential therapeutic approach, and has also been used in other disciplines, such as in competitive sports. In this context, adverse outcomes involving cardiovascular, cognitive, metabolic, and cancer problems have emerged in obstructive sleep apnea-based studies, whereas beneficial effects of IH have also been identified. Those a priori contradictory findings may not be as contradictory as initially thought. Indeed, th...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Almendros, I., Wang, Y., Gozal, D. Tags: REVIEW Source Type: research

Maternal stress during pregnancy increases neonatal allergy susceptibility: Role of glucocorticoids
We sought to test experimentally whether maternal stress can promote susceptibility to development of asthma-like allergic airways disease in offspring. Normal pregnant mice (day 15) were subjected to a single restraint stress exposure. We subsequently tested their offspring for the development of airway hyperreactivity (AHR) and allergic airway inflammation (AI), after an intentionally suboptimal sensitization protocol. The offspring of stressed mothers showed levels of AI and enhanced airway responses to methacholine comparable to those seen in fully sensitized and challenged positive control animals; in contrast, minima...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Lim, R., Fedulov, A. V., Kobzik, L. Tags: ARTICLES Source Type: research

Nicotine alters mucin rheological properties
Tobacco smoke exposure, the major cause of chronic obstructive pulmonary disease (COPD), instigates a dysfunctional clearance of thick obstructive mucus. However, the mechanism underlying the formation of abnormally viscous mucus remains elusive. We investigated whether nicotine can directly alter the rheological properties of mucin by examining its physicochemical interactions with human airway mucin gels secreted from A549 lung epithelial cells. Swelling kinetics and multiple particle tracking were utilized to assess mucin gel viscosity change when exposed to nicotine. Herein we show that nicotine (≤50 nM) significant...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Chen, E. Y., Sun, A., Chen, C.-S., Mintz, A. J., Chin, W.-C. Tags: ARTICLES Source Type: research

TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury
The treatment of acute lung injury caused by exposure to reactive chemicals remains challenging because of the lack of mechanism-based therapeutic approaches. Recent studies have shown that transient receptor potential vanilloid 4 (TRPV4), an ion channel expressed in pulmonary tissues, is a crucial mediator of pressure-induced damage associated with ventilator-induced lung injury, heart failure, and infarction. Here, we examined the effects of two novel TRPV4 inhibitors in mice exposed to hydrochloric acid, mimicking acid exposure and acid aspiration injury, and to chlorine gas, a severe chemical threat with frequent expos...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Balakrishna, S., Song, W., Achanta, S., Doran, S. F., Liu, B., Kaelberer, M. M., Yu, Z., Sui, A., Cheung, M., Leishman, E., Eidam, H. S., Ye, G., Willette, R. N., Thorneloe, K. S., Bradshaw, H. B., Matalon, S., Jordt, S.-E. Tags: ARTICLES Source Type: research

Autophagy in pulmonary macrophages mediates lung inflammatory injury via NLRP3 inflammasome activation during mechanical ventilation
The inflammatory response is a primary mechanism in the pathogenesis of ventilator-induced lung injury. Autophagy is an essential, homeostatic process by which cells break down their own components. We explored the role of autophagy in the mechanisms of mechanical ventilation-induced lung inflammatory injury. Mice were subjected to low (7 ml/kg) or high (28 ml/kg) tidal volume ventilation for 2 h. Bone marrow-derived macrophages transfected with a scrambled or autophagy-related protein 5 small interfering RNA were administered to alveolar macrophage-depleted mice via a jugular venous cannula 30 min before the start of the ...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Zhang, Y., Liu, G., Dull, R. O., Schwartz, D. E., Hu, G. Tags: ARTICLES Source Type: research

EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production
Airway epithelial cells are the primary cell type involved in respiratory viral infection. Upon infection, airway epithelium plays a critical role in host defense against viral infection by contributing to innate and adaptive immune responses. Influenza A virus, rhinovirus, and respiratory syncytial virus (RSV) represent a broad range of human viral pathogens that cause viral pneumonia and induce exacerbations of asthma and chronic obstructive pulmonary disease. These respiratory viruses induce airway epithelial production of IL-8, which involves epidermal growth factor receptor (EGFR) activation. EGFR activation involves ...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Kalinowski, A., Ueki, I., Min-Oo, G., Ballon-Landa, E., Knoff, D., Galen, B., Lanier, L. L., Nadel, J. A., Koff, J. L. Tags: ARTICLES Source Type: research

Arginase II is a target of miR-17-5p and regulates miR-17-5p expression in human pulmonary artery smooth muscle cells
Vascular remodeling and smooth muscle cell proliferation are hallmark pathogenic features of pulmonary artery hypertension. MicroRNAs, endogenously expressed small noncoding RNAs, regulate gene expression at the posttranscriptional level. It has previously been shown that miR-17 overexpression in cultured human pulmonary artery smooth muscle cell (hPASMC) resulted in increased viable cell number. Previously, we have found that arginase II promotes hypoxia-induced proliferation in hPASMC. Therefore, we hypothesized that miR-17 would be upregulated by hypoxia in hPASMC and would result in greater arginase II expression. We f...
Source: AJP: Lung Cellular and Molecular Physiology - July 15, 2014 Category: Respiratory Medicine Authors: Jin, Y., Jin, Y., Chen, B., Tipple, T. E., Nelin, L. D. Tags: ARTICLES Source Type: research

Polypharmacy among nonagenarians/centenarians in rural China
ConclusionsAlthough most subjects suffering from some chronic diseases, minor polypharmacy and major polypharmacy are not common among nonagenarians/centenarians in rural China. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - July 15, 2014 Category: Internal Medicine Authors: Ming Yang, Jing Lu, Li Luo, Qiukui Hao, Birong Dong Tags: Original Article Source Type: research

Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation
This study aims to investigate mitochondrial function and miR expression in the right (RA) and left atria (LA) of patients with AF and sinus rhythm (SR). Myocardial tissue from the RA and LA appendages was investigated in 37 patients with AF (n = 21) or SR (n = 16) undergoing coronary artery bypass surgery and/or heart valve surgery. Mitochondrial respiration was measured in situ after tissue permeabilization by saponin. MiR expression was assessed by miR array and real-time quantitative reverse-transcription polymerase chain reaction. Maximal mitochondrial respiratory rate was increased in both RA and LA tissue of patient...
Source: Physiological Genomics - July 15, 2014 Category: Genetics & Stem Cells Authors: Slagsvold, K. H., Johnsen, A. B., Rognmo, O., Hoydal, M. A., Wisloff, U., Wahba, A. Tags: Call for Papers: Mitochondrial Metabolism Source Type: research

Animal Models of Allergic Airways Disease: Where Are We and Where to Next?
Abstract In a complex inflammatory airways disease such as asthma, abnormalities in a plethora of molecular and cellular pathways ultimately culminate in characteristic impairments in respiratory function. The ability to study disease pathophysiology in the setting of a functioning immune and respiratory system therefore makes mouse models an invaluable tool in translational research. Despite the vast understanding of inflammatory airways diseases gained from mouse models to date, concern over the validity of mouse models continues to grow. Therefore the aim of this review is two‐fold; firstly, to evaluate mouse models o...
Source: Journal of Cellular Biochemistry - July 15, 2014 Category: Biochemistry Authors: David G. Chapman, Jane E. Tully, James D. Nolin, Yvonne M Jansen‐Heininger, Charles G. Irvin Tags: Prospects Source Type: research

Recruitment and plasticity in diaphragm, intercostal, and abdominal muscles in unanesthetized rats
Although rats are a frequent model for studies of plasticity in respiratory motor control, the relative capacity of rat accessory respiratory muscles to express plasticity is not well known, particularly in unanesthetized animals. Here, we characterized external intercostal (T2, T4, T5, T6, T7, T8, T9 EIC) and abdominal muscle (external oblique and rectus abdominis) electromyogram (EMG) activity in unanesthetized rats via radiotelemetry during normoxia (Nx: 21% O2) and following acute intermittent hypoxia (AIH: 10 x 5-min, 10.5% O2; 5-min intervals). Diaphragm and T2–T5 EIC EMG activity, and ventilation were also ass...
Source: Journal of Applied Physiology - July 15, 2014 Category: Physiology Authors: Navarrete-Opazo, A., Mitchell, G. S. Tags: HIGHLIGHTED TOPIC Source Type: research

Possible delayed respiratory depression following intrathecal injection of morphine and bupivacaine in an alpaca
Abstract ObjectiveTo describe general anesthesia and successful treatment of an alpaca, which developed respiratory arrest 2 hours after intrathecal injection of morphine and bupivacaine. Case SummaryA 10‐day‐old female alpaca weighing 7.3 kg was presented to our hospital with a fractured right tibia. The cria was anesthetized to repair the fracture with a dynamic compression plate. Anesthesia was induced with IV propofol and maintained with sevoflurane in 100% oxygen. Prior to the start of surgery the alpaca received an unintended intrathecal injection of 0.6 mL of a solution of 0.5 mg morphine (0.068 mg/kg) and 1.5 m...
Source: Journal of Veterinary Emergency and Critical Care - July 15, 2014 Category: Veterinary Research Authors: Miguel Martínez LdoVet, Pamela J. Murison, Jo Murrell Tags: Case Report Source Type: research

Mechanical ventilation and management of an adult horse with presumptive botulism
Abstract ObjectiveTo describe the clinical course, management, and outcome of a horse with a presumptive diagnosis of botulism treated with long‐term mechanical ventilation. Case SummaryA 6‐year‐old Quarter Horse gelding with a history of esophageal obstruction was evaluated for progressive tetraparesis. Generalized and progressive skeletal muscle weakness characterized by recumbency, decreased tongue, tail, eyelid, and anal tone, and respiratory failure was observed. Anticholinergic signs including decreased salivation, xerophthalmia, and ileus were also noted. A presumptive diagnosis of botulism was made, although ...
Source: Journal of Veterinary Emergency and Critical Care - July 15, 2014 Category: Veterinary Research Authors: Sandra D. Taylor, Balazs Toth, Wendy M. Townsend, Robin Timothy Bentley Tags: Case Report Source Type: research

Is Bilateral Pulmonary Lobectomy Feasible in Patients with Bilateral Lung Cancers?
Conclusion Although appropriate patient selection and careful perioperative management are mandatory, bilateral pulmonary lobectomy could be an acceptable procedure for patients with bilateral lung cancers. PMID: 25025891 [PubMed - as supplied by publisher] (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - July 15, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Hattori A, Suzuki K, Takamochi K, Oh S Tags: Thorac Cardiovasc Surg Source Type: research

A case of Invasive pulmonary infection caused by novel species of Perenniporia
We report herein a case of invasive pulmonary infection caused by the novel species of Perenniporia in a 44‐year‐old woman with active systemic lupus erythematosus who was successfully treated with voriconazole. (Source: Mycoses)
Source: Mycoses - July 15, 2014 Category: Research Authors: Pitaks Detporntewan, Ariya Chindamporn, Navaporn Worasilchai, Chusana Suankratay Tags: Case Report Source Type: research

Does manual therapy provide additional benefit to breathing retraining in the management of dysfunctional breathing? A randomised controlled trial.
Conclusion: Breathing retraining is currently the mainstay of treatment for patients with DB. The results of this study suggest MT provides no additional benefit in this patient group. Implications for Rehabilitation Dysfunctional breathing (DB) is associated with significant patient morbidity but often goes unrecognised, leading to prolonged investigation and significant use of health care resources. Breathing retraining remains the primary management of this condition. However, physiotherapists are also using manual therapy (MT) as an adjunctive treatment for patients with DB. However, the results of this study suggest t...
Source: Disability and Rehabilitation - July 15, 2014 Category: Rehabilitation Authors: Jones M, Troup F, Nugus J, Roughton M, Hodson M, Rayner C, Bowen F, Pryor J Tags: Disabil Rehabil Source Type: research

Bronchial chloroma.
PMID: 25025362 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Faiz SA, Ordonez NG, Morice RC, Bashoura L, Jimenez CA Tags: Am J Respir Crit Care Med Source Type: research

Vertebral erosion: an uncommon complication of tracheal tubes.
PMID: 25025361 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Petrache I, Patel D, Wolf KM, Winer-Muram H Tags: Am J Respir Crit Care Med Source Type: research

Reply: Practice Guideline for Pulmonary Hypertension in Sickle Cell: Direct Evidence Needed before Universal Adoption.
PMID: 25025360 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Klings ES, Machado RF, Morris CR, Gordeuk VR, Kato GJ, Ataga KI, Castro O, Hsu L, Telen MJ, Krishnamurti L, Steinberg MH, Gladwin MT, ATS Clinical Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension in Sickle Cell Disease Committee Tags: Am J Respir Crit Care Med Source Type: research

Practice Guideline for Pulmonary Hypertension in Sickle Cell: Direct Evidence Needed before Universal Adoption.
PMID: 25025359 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Hassell KL, Afenyi-Annan A, Ballas SK, Buchanan GR, Eckman JR, Jordan L, Lanzkron S, Lottenberg R, Ware R Tags: Am J Respir Crit Care Med Source Type: research

Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter.
PMID: 25025358 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Alexis NE, Huang YC, Rappold AG, Kehrl H, Devlin R, Peden DB Tags: Am J Respir Crit Care Med Source Type: research

Inferior vena cava diameter may be misleading in detecting central venous pressure elevation induced by acute pulmonary hypertension.
PMID: 25025357 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Bouzat P, Walther G, Rupp T, Levy P, Vergès S Tags: Am J Respir Crit Care Med Source Type: research

Nuclear Magnetic Resonance-based Metabolomics Discriminates Primary Ciliary Dyskinesia from Cystic Fibrosis.
PMID: 25025356 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Montuschi P, Paris D, Montella S, Melck D, Mirra V, Santini G, Mores N, Montemitro E, Majo F, Lucidi V, Bush A, Motta A, Santamaria F Tags: Am J Respir Crit Care Med Source Type: research

Neural Respiratory Drive and Ventilation in Patients with Chronic Obstructive Pulmonary Disease during Sleep.
PMID: 25025355 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Luo YM, He BT, Wu YX, Yuan H, Xu J, Moxham J, Polkey M Tags: Am J Respir Crit Care Med Source Type: research

Endobronchial tuberculosis with anthracofibrosis.
PMID: 25025354 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Paulin LM, West NE, Akulian JA, Garibaldi BT Tags: Am J Respir Crit Care Med Source Type: research

Sleep apnea and diabetes: good friends or something more?
PMID: 25025353 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Bakker JP, Patel SR Tags: Am J Respir Crit Care Med Source Type: research

Pulmonary Hypertension due to Fibrotic Lung Disease: Hidden Value in a Neutral Trial.
PMID: 25025352 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Nathan SD, Carbone RG Tags: Am J Respir Crit Care Med Source Type: research

Wnt/β-Catenin and Transforming Growth Factor-β Signaling in Pulmonary Fibrosis. A Case for Antagonistic Pleiotropy?
PMID: 25025351 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Scheraga RG, Thannickal VJ Tags: Am J Respir Crit Care Med Source Type: research

Ivacaftor: from bench to bedside . . . And back again.
PMID: 25025350 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Molloy K, McElvaney NG Tags: Am J Respir Crit Care Med Source Type: research

A new player in the game: epithelial cathepsin s in early cystic fibrosis lung disease.
PMID: 25025349 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 15, 2014 Category: Respiratory Medicine Authors: Mall MA, Schultz C Tags: Am J Respir Crit Care Med Source Type: research