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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen
An upsurge of Middle East respiratory syndrome coronavirus (MERS-CoV) infection has been recently described in countries of the Arabian Peninsula resulting in exported cases from these countries to the European Union [1]. Cases of MERS-CoV infection are associated with a high case fatality rate since there is no available treatment. There is a scarcity of data on specific therapeutic interventions for the disease. Published reports propose the use of known antivirals based on extrapolation of data from: (i) the severe acute respiratory syndrome (SARS) epidemic that was also associated with the circulation of a novel corona...
Source: International Journal of Antimicrobial Agents - September 18, 2014 Category: Drugs & Pharmacology Authors: Nicholas Spanakis, Sotirios Tsiodras, Bart L. Haagmans, V. Stalin Raj, Kostantinos Pontikis, Antonia Koutsoukou, Nikos Koulouris, Albert D.M.E. Osterhaus, Marion P.G. Koopmans, Athanassios Tsakris Source Type: research

Electronic nicotine delivery systems for smoking cessation: where are we?
Abstract Electronic cigarettes (e-cigarettes) have surged in popularity since their introduction in 2007. Sales of e-cigarettes and related products in the US were expected to exceed $1B in 2013. With the popularity of the electronic cigarette on the rise, physicians are sure to get questions from patients about the safety of e-cigarettes and their effectiveness as tools for smoking cessation or reduction. Most users of the electronic cigarette are so-called dual users—current cigarette smokers who also use e-cigarettes. The appeal of these devices is largely based on a perception that they are not as harmful as...
Source: Current Respiratory Care Reports - September 18, 2014 Category: Respiratory Medicine Source Type: research

Differential proteomic profiling unveils new molecular mechanisms associated with mitochondrial complex III deficiency.
Abstract We have analyzed the cellular pathways and metabolic adaptations that take place in primary skin fibroblasts from patients with mutations in BCS1L, a major genetic cause of mitochondrial complex III enzyme deficiency. Mutant fibroblasts exhibited low oxygen consumption rates and intracellular ATP levels, indicating that the main altered molecular event probably is a limited respiration-coupled ATP production through the OXPHOS system. Two-dimensional DIGE and MALDI-TOF/TOF mass spectrometry analyses unambiguously identified 39 proteins whose expression was significantly altered in complex III-deficient fib...
Source: Journal of Proteomics - September 18, 2014 Category: Biochemistry Authors: Marín-Buera L, García-Bartolomé A, Morán M, López-Bernardo E, Cadenas S, Hidalgo B, Sánchez R, Seneca S, Arenas J, Martín MA, Ugalde C Tags: J Proteomics Source Type: research

Additive protection induced by mixed virus-like particles presenting respiratory syncytial virus fusion or attachment glycoproteins.
Abstract Respiratory syncytial virus (RSV) is the most important pathogen for lower respiratory tract illness in infants and a high priority for vaccine development. We previously reported that RSV virus-like particles (VLPs) expressing either the fusion (F) or attachment (G) glycoprotein could confer protection against RSV challenge in BALB/c mice. Here, we tested the hypothesis that RSV VLP vaccine efficacy can be enhanced by mixing RSV VLP F and RSV VLP G, and we analyzed host responses to these RSV VLPs. Mice were immunized with VLP F, VLP G, or VLP F+VLP G. Lung viral loads in BALB/c mice following RSV strain ...
Source: Antiviral Research - September 18, 2014 Category: Virology Authors: Lee S, Quan FS, Kwon Y, Sakamoto K, Kang SM, Compans RW, Moore ML Tags: Antiviral Res Source Type: research

Rapid and sensitive detection of type II porcine reproductive and respiratory syndrome virus by reverse transcription loop-mediated isothermal amplification combined with a vertical flow visualization strip.
Abstract Reverse transcription-loop-mediated isothermal amplification (RT-LAMP) was combined with a vertical flow (VF) nucleic acid detection strip to develop a universal assay for the detection of type II porcine reproductive and respiratory syndrome virus (PRRSV). The loop primers were labeled separately with biotin and fluorescein isothiocyanate (FITC) in this assay. Using optimized parameters, the whole reaction could be completed in <50min in a completely enclosed environment. The detection limit of this assay was found to be 1pg RNA, 30 tissue culture infective dose 50 (TCID50) virus, or 230 copies of reco...
Source: Journal of Virological Methods - September 18, 2014 Category: Virology Authors: Gou H, Deng J, Pei J, Wang J, Liu W, Zhao M, Chen J Tags: J Virol Methods Source Type: research

Advances in melatonergic agents
Carocci A, Catalano A, Sinicropi MS (Source: International Journal of COPD)
Source: International Journal of COPD - September 17, 2014 Category: Respiratory Medicine Source Type: research

Open Versus Endovascular Repair of Thoracic Aortic Aneurysms: A Nationwide Inpatient Sample Study
Conclusions: Nationwide data comparing open and TEVAR in the United States reveal decreased postoperative mortality and a decreased incidence of postoperative neurologic, cardiac, and respiratory complications for TEVAR. (Source: Vascular and Endovascular Surgery)
Source: Vascular and Endovascular Surgery - September 17, 2014 Category: Surgery Authors: Hughes, K., Guerrier, J., Obirieze, A., Ngwang, D., Rose, D., Tran, D., Cornwell, E., Obisesan, T., Preventza, O. Tags: Articles Source Type: research

Mice Deficient in the Gene for Cytochrome P450 (CYP)1A1 Are More Susceptible Than Wild-Type to Hyperoxic Lung Injury: Evidence for Protective Role of CYP1A1 Against Oxidative Stress
Hyperoxia contributes to acute lung injury in diseases such as acute respiratory distress syndrome in adults and bronchopulmonary dysplasia in premature infants. Cytochrome P450 (CYP)1A1 has been shown to modulate hyperoxic lung injury. The mechanistic role(s) of CYP1A1 in hyperoxic lung injury in vivo is not known. In this investigation, we hypothesized that Cyp1a1(–/–) mice would be more susceptible to hyperoxic lung injury than wild-type (WT) mice, and that the protective role of CYP1A1 is in part due to CYP1A1-mediated decrease in the levels of reactive oxygen species-mediated lipid hydroperoxides, e.g., F2...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: Lingappan, K., Jiang, W., Wang, L., Wang, G., Couroucli, X. I., Shivanna, B., Welty, S. E., Barrios, R., Khan, M. F., Nebert, D. W., Roberts, L. J., Moorthy, B. Tags: Inhalation and Respiratory Source Type: research

Keto Amphetamine Toxicity--Focus on the Redox Reactivity of the Cathinone Designer Drug Mephedrone
The β-keto amphetamine (cathinone, β-KA) designer drugs such as mephedrone (4-methylmethcathinone, 4-MMC) show a large degree of structural similarity to amphetamines like methamphetamine (METH). However, little is currently known about whether these substances also share the potential neurotoxic properties of their non-keto amphetamine counterparts, or what mechanisms could be involved. Here, we evaluate the cytotoxicity of β-KAs in SH-SY5Y cells using lactate dehydrogenase (LDH) assays, assess the redox potential of a range of β-KAs and non-keto amphetamines using the sensitive redox indicator 2-(4-Io...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: den Hollander, B., Sundstrom, M., Pelander, A., Ojanpera, I., Mervaala, E., Korpi, E. R., Kankuri, E. Tags: Neurotoxicology Source Type: research

Progress in Assessing Air Pollutant Risks from In Vitro Exposures: Matching Ozone Dose and Effect in Human Airway Cells
In vitro exposures to air pollutants could, in theory, facilitate a rapid and detailed assessment of molecular mechanisms of toxicity. However, it is difficult to ensure that the dose of a gaseous pollutant to cells in tissue culture is similar to that of the same cells during in vivo exposure of a living person. The goal of the present study was to compare the dose and effect of O3 in airway cells of humans exposed in vivo to that of human cells exposed in vitro. Ten subjects breathed labeled O3 (18O3, 0.3 ppm, 2 h) while exercising intermittently. Bronchial brush biopsies and lung lavage fluids were collected 1 h post ex...
Source: Toxicological Sciences - September 17, 2014 Category: Toxicology Authors: Hatch, G. E., Duncan, K. E., Diaz-Sanchez, D., Schmitt, M. T., Ghio, A. J., Carraway, M. S., McKee, J., Dailey, L. A., Berntsen, J., Devlin, R. B. Tags: Inhalation and Respiratory Source Type: research

Outcome and prognostic factors of resected non-small-cell lung cancer invading the diaphragm
CONCLUSIONS Resection of NSCLC invading the diaphragm is technically feasible and could be a valid therapeutic option with acceptable morbidity and mortality and long-term survival in highly selected patients. (Source: Interactive CardioVascular and Thoracic Surgery)
Source: Interactive CardioVascular and Thoracic Surgery - September 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Galetta, D., Borri, A., Casiraghi, M., Gasparri, R., Petrella, F., Tessitore, A., Serra, M., Guarize, J., Spaggiari, L. Tags: Mediastinum, Diaphragm THORACIC Source Type: research

Extracorporeal membrane oxygenation as a support for emergency bronchial reconstruction in a traumatic patient with severe hypoxaemia
Extracorporeal membrane oxygenation (ECMO) is an extracorporeal life support technique to provide cardiac and/or respiratory assistance to patients. ECMO has been demonstrated to be beneficial for the life support of selected traumatic individuals. However, the application of arteriovenous ECMO as an intraoperative support strategy in emergency operations has rarely been described. The presented case involves a 31-year old male who sustained a right bronchial rupture and other multiple injuries in a car accident. His right main bronchus was sewn completely closed during the first operation in a local hospital, and he devel...
Source: Interactive CardioVascular and Thoracic Surgery - September 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Liu, C., Lin, Y., Du, B., Liu, L. Tags: Congenital - cyanotic THORACIC Source Type: research

Republished: Smoking-related interstitial fibrosis (SRIF): pathologic findings and distinction from other chronic fibrosing lung diseases
Smoking-related interstitial fibrosis (SRIF) is a common, histologically striking finding in smokers that must be distinguished from the idiopathic interstitial pneumonias and other chronic interstitial fibrosing lesions. It is characterised by marked thickening of alveolar septa by fibrosis composed of thick collagen bundles that have a distinctive hyalinised quality and often are admixed with variable numbers of hyperplastic smooth muscle fibres. There is minimal accompanying inflammation. This fibrosis is usually most prominent in subpleural and centrilobular parenchyma, but can be present elsewhere as well. It is accom...
Source: Postgraduate Medical Journal - September 17, 2014 Category: Journals (General) Authors: Katzenstein, A.-L. A. Tags: Reviews Source Type: research

Animal models of disease shed light on Nipah virus pathogenesis and transmission
Abstract Nipah virus is an emerging virus infection that causes yearly disease outbreaks with high case fatality rates in Bangladesh. Nipah virus causes encephalitis and systemic vasculitis, sometimes in combination with respiratory disease. Pteropus species fruit bats are the natural reservoir of Nipah virus and zoonotic transmission can occur directly or via an intermediate host; human‐to‐human transmission occurs regularly. In this review we discuss the current state of knowledge on the pathogenesis and transmission of Nipah virus, focusing on dissemination of the virus through its host, known determinants of pathog...
Source: The Journal of Pathology - September 17, 2014 Category: Pathology Authors: Emmie de Wit, Vincent J. Munster Tags: Invited Review Source Type: research

Linking bioregulatory systems: Reciprocal autonomic activation predicts sleep over 1 year in middle childhood
This study examined reactivity to social‐evaluative stress in the parasympathetic (PNS) and sympathetic (SNS) branches of the autonomic nervous system (ANS) as prospective predictors of sleep in middle childhood. Participants included 339 children (M age = 9 years and 5 months at T1; 54% female; 64% European American, 36% African American). Sleep efficiency, sleep minutes, and variability in sleep onset time were assessed with actigraphy for seven consecutive nights at T1 and 1 year later at T2. Respiratory sinus arrhythmia reactivity (RSAR) and skin conductance level reactivity (SCLR) were assessed in response to a ...
Source: Developmental Psychobiology - September 17, 2014 Category: Psychiatry & Psychology Authors: Stephen Erath, Mona El‐Sheikh Tags: Research Article Source Type: research

Omalizumab: a new treatment option for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
Conclusion: Omalizumab has the potential to be an additional and solitary treatment option in patients with CF and ABPA. Early onset treatment may be beneficial and patients with early stage of lung disease seem to benefit more. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Lehmann, S., Pfannenstiel, C., Friedrichs, F., Kroger, K., Wagner, N., Tenbrock, K. Tags: Original Research Source Type: research

{alpha}1 Antitrypsin deficiency: current best practice in testing and augmentation therapy
α1 Antitrypsin deficiency (AATD) increases the risk of chronic obstructive pulmonary disease (COPD), liver disease and other conditions. Although it is not a rare disease, it is a condition rarely diagnosed because of unawareness by most healthcare providers who manage subjects at risk. Testing recommendations have been published and strongly suggest testing all subjects with confirmed COPD, cryptogenic liver cirrhosis, subjects with incompletely reversible airflow obstruction and siblings of affected individuals. Testing strategies usually imply a combination of measures of α1 antitrypsin (AAT) levels, phenoty...
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Campos, M. A., Lascano, J. Tags: Review Source Type: research

Endobronchial lipoma: bronchoscopy, imaging and pathology
(Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Harris, K., Dhillon, S., Huang, M., Kumar, A., Qiu, J. Tags: Letter to the Editor Source Type: research

Bone marrow mesenchymal stem cells protect alveolar macrophages from lipopolysaccharide-induced apoptosis partially by inhibiting the Wnt/β-catenin pathway.
In conclusion, BMSCs can attenuate AM apoptosis partially by suppressing the Wnt/β-catenin pathway. PMID: 25229877 [PubMed - as supplied by publisher] (Source: Cell Biology International)
Source: Cell Biology International - September 17, 2014 Category: Cytology Authors: Li B, Zhang H, Zeng M, He W, Li M, Huang X, Deng DY, Wu J Tags: Cell Biol Int Source Type: research

Therapeutic Potential of Intermittent Hypoxia: A Matter of Dose.
Abstract Intermittent hypoxia (IH) has been the subject of considerable research in recent years, and triggers a bewildering array of both detrimental and beneficial effects in multiple physiological systems. Here, we review extensive literature concerning IH, and its impact on the respiratory, cardiovascular, immune, metabolic, bone and nervous systems. One major goal is to define relevant IH characteristics leading (differentially) to safe, protective and/or therapeutic effects versus pathogenesis. To understand the impact of IH, it is essential to define critical characteristics of the IH protocol under investig...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - September 17, 2014 Category: Physiology Authors: Navarrete-Opazo AA, Mitchell GS Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Clostridium huakuii sp. nov., a novel anaerobic acetogenic bacterium isolated from methanogenic consortia.
Abstract A Gram-staining-positive, spore-forming, obligate anaerobic acetogenic bacterium, designated LAM1030 (T), was isolated from methanogenic consortia enriched from biogas slurry collected from the large-scale anaerobic digester of Modern Farming Corporation in Hebei Province, China. Cells of strain LAM1030(T) were motile, straight or spiral-rod-shaped. Strain LAM1030(T) could utilize glucose, fructose, maltose, galacatose, lactose, sucrose, cellobiose,mannitol, pyruvate, succinic acid, tryptophan as sole carbon source. Acetic acid, isovaleric acid and butanoic acid were the main productions of glucose ferme...
Source: International Journal of Systematic and Evolutionary Microbiology - September 17, 2014 Category: Microbiology Authors: Ruan Z, Wang Y, Zhang C, Song J, Zhai Y, Zhuang Y, Wang H, Chen X, Li Y, Zhao B, Zhao B Tags: Int J Syst Evol Microbiol Source Type: research

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments-The importance of immunofocusing in subunit vaccine design.
Abstract The newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is currently spreading among humans, making development of effective MERS vaccines a high priority. A defined receptor-binding domain (RBD) in MERS-CoV spike protein can potentially serve as a subunit vaccine candidate against MERS-CoV infections. To identify an ideal vaccine candidate, we have constructed five different versions of RBD fragments, S350-588-Fc, S358-588-Fc, S367-588-Fc, S367-606-Fc, and S377-588-Fc (their names indicate their residue range in the spike protein and their C-terminal Fc tag), and further investigated the...
Source: Vaccine - September 17, 2014 Category: Allergy & Immunology Authors: Ma C, Wang L, Tao X, Zhang N, Yang Y, Tseng CT, Li F, Zhou Y, Jiang S, Du L Tags: Vaccine Source Type: research

From newborn to toddler: the report of two cases with Congenital Granular Cell Tumor
A congenital granular cell tumor (CGCT) is an uncommon benign soft tissue lesion that usually arises from the alveolar ridge in newborns. It may severely interfere with respiratory and feeding systems, if left untreated. This paper is a case report of two newborn babies with protruded intraoral tumors severely compromising breastfeeding. Tumors were removed by water laser without the need for suture and pain medication. Histopathological assessments were accomplished for definitive diagnosis and children were followed until full primary dentition was observed without any sign of CGCT recurrence. (Source: Journal of Oral an...
Source: Journal of Oral and Maxillofacial Surgery - September 17, 2014 Category: ENT & OMF Authors: Yong-Dae Kwon, Mi Sun Kim, Ana Lucia Seminario, Sung Chul Choi Tags: Case Report Source Type: research

Estrogen regulates energy metabolic pathway and upstream adenosine 5′‐monophosphate‐activated protein kinase and phosphatase enzyme expression in dorsal vagal complex metabolosensory neurons during glucostasis and hypoglycemia
This study investigates the hypothesis that estrogen regulates A2 AMPK through control of fuel metabolism and/or upstream protein kinase/phosphatase enzyme expression. A2 cells were harvested by laser microdissection after insulin or vehicle (V) injection of E‐ or oil (O)‐implanted ovariectomized female rats. Cell lysates were evaluated by immunoblot for glycolytic, tricarboxylic acid cycle, respiratory chain, and acetyl‐CoA‐malonyl‐CoA pathway enzymes. A2 phosphofructokinase (PFKL), isocitrate dehydrogenase, pyruvate dehydrogenase, and ATP synthase subunit profiles were elevated in E/V vs. O/V; hypoglycemia augm...
Source: Journal of Neuroscience Research - September 17, 2014 Category: Neuroscience Authors: Pratistha Tamrakar, Baher A. Ibrahim, Amit D. Gujar, Karen P. Briski Tags: Research Article Source Type: research

Immunocytochemical markers of neuronal maturation in human diagnostic neuropathology
Abstract Histological descriptions of morphogenesis in human fetal brain and in malformations and tumours can now be supplemented by the timing and sequence of the maturation of individual neurons. In human neuropathology, this is principally achieved by immunocytochemical reactivities used as maturational markers of neuronal properties denoted by molecules and cell products. Cytological markers can appear early and then regress, often being replaced by more mature molecules, or might not exhibit the onset of immunoreactivity until a certain stage of neuronal differentiation is achieved, some early, others interme...
Source: Cell and Tissue Research - September 17, 2014 Category: Cytology Source Type: research

Efficiency of different decalcification protocols for nasal osseous structures in a rat experimental model of allergic rhinitis, and their effects on epithelial histology: An attempt at standardization.
CONCLUSIONS: EDTA treatment for 20 days is appropriate for decalcification of nasal structures in rat models of allergic rhinitis; further incubation preserves epithelial integrity but is not required. When urgency is a factor, formic-acid-based decalcification for 5 days yields acceptable results. PMID: 25238695 [PubMed - as supplied by publisher] (Source: Experimental and Toxicologic Pathology)
Source: Experimental and Toxicologic Pathology - September 17, 2014 Category: Pathology Authors: Guibas GV, Lakis S, Gkimpas C, Manda M, Kapoukranidou D, Spandou E Tags: Exp Toxicol Pathol Source Type: research

Effects of repeated Cr(VI) intratracheal instillation on club (clara) cells and activation of nuclear factor-kappa B pathway via oxidative stress.
Abstract Hexavalent chromium [Cr(VI)] exposure is known to induce respiratory inflammation and contribute to lung cancer development, but little is known about its target cell type in lung. In the current study, we investigated the effects of repeated Cr(VI) intratracheal instillation on club (clara) cells and club (clara) cell secretory protein (CC16) in rats and explored whether the nuclear factor-kappa B (NF-κB) related pathway was involved. We also studied the role of orally delivered Zn against Cr-induced adverse health effects. For four weeks, sixty Sprague-Dawley male rats received weekly intratracheal inst...
Source: Toxicology Letters - September 17, 2014 Category: Toxicology Authors: Zhao L, Song Y, Pu J, Guo J, Wang Y, Chen Z, Chen T, Gu Y, Jia G Tags: Toxicol Lett Source Type: research

Pennsylvania among 12 states reporting respiratory virus outbreak
Pennsylvania is among a dozen states where cases of a severe respiratory illness have been identified, the Centers for Disease Control and Prevention said Tuesday. Enterovirus D68 causes mild symptoms, including fever, runny nose, sneezing and coughing. Most of the children who got very ill from the virus in Missouri and Illinois had difficulty breathing, according to the CDC. In general, infants, children and teenagers are most likely to get infected. In all, 130 cases have been confirmed between… (Source: Health Care:Biotechnology headlines)
Source: Health Care:Biotechnology headlines - September 16, 2014 Category: Biotechnology Authors: Kris B. Mamula Source Type: research

Maternal Behavior and Infant Physiology During Feeding in Premature and Term Infants Over the First Year of Life
Abstract Little is known about the relationship between maternal behavior and the stability of premature infants' physiologic responses during feeding. In a secondary data analysis, we examined relationships between quality of maternal behavior and cardiorespiratory physiology during feeding in 61 premature and 53 term infants at four times over the first year of life. Measures included heart rate (HR), respiratory rate (RR), and oxygen saturation; Child Feeding Skills Checklist; and Parent‐Child Early Relational Assessment. Birthweight, gestational age, and neurodevelopmental risk were covariates. Quality of maternal be...
Source: Research in Nursing and Health - September 16, 2014 Category: Nursing Authors: Ashley M. Weber, Tondi M. Harrison Tags: Research Article Source Type: research

Interstitial lung disease: raising the index of suspicion in primary care.
Abstract Interstitial lung disease (ILD) describes a group of diseases that cause progressive scarring of the lung tissue through inflammation and fibrosis. The most common form of ILD is idiopathic pulmonary fibrosis, which has a poor prognosis. ILD is rare and mainly a disease of the middle-aged and elderly. The symptoms of ILD-chronic dyspnoea and cough-are easily confused with the symptoms of more common diseases, particularly chronic obstructive pulmonary disease and heart failure. ILD is infrequently seen in primary care and a precise diagnosis of these disorders can be challenging for physicians who rarely e...
Source: Respiratory Care - September 16, 2014 Category: Respiratory Medicine Authors: D Zibrak J, Price D Tags: NPJ Prim Care Respir Med Source Type: research

Non-cardiac issues in patients with heterotaxy syndrome
This article briefly reviews the implications of gastrointestinal, immunologic, genitourinary, respiratory, and central nervous system involvement in HS patients with a view to aid in their comprehensive clinical management. (Source: Annals of Pediatric Cardiology)
Source: Annals of Pediatric Cardiology - September 16, 2014 Category: Cardiology Authors: Shyam S Kothari Source Type: research

Phenotype of matrin‐3–related distal myopathy in 16 German patients
ObjectiveTo characterize the phenotype of patients with distal myopathy with vocal cord and pharyngeal weakness due to the p.S85C mutation in the matrin‐3 gene (MATR3, Mendelian Inheritance in Man 164015). Recently, it has been suggested that patients with this mutation may suffer from familial amyotrophic lateral sclerosis. MethodsSixteen patients from 6 families with late onset distal myopathy associated with the p.S85C MATR3 mutation were characterized. ResultsPatients had a predominantly distal muscle weakness, most severely affecting ankle and wrist dorsiflexion. Relevant proximal and axial weakness was found in 6 a...
Source: Annals of Neurology - September 16, 2014 Category: Neurology Authors: Tobias J. Müller, Torsten Kraya, Gisela Stoltenburg‐Didinger, Frank Hanisch, Malte Kornhuber, Dietrich Stoevesandt, Jan Senderek, Joachim Weis, Petra Baum, Marcus Deschauer, Stephan Zierz Tags: Research Article Source Type: research

Burnout in the NICU setting and its relation to safety culture
Conclusions NICU caregiver burnout appears to have ‘climate-like’ features, is prevalent, and associated with lower perceptions of patient safety culture. (Source: Quality and Safety in Health Care)
Source: Quality and Safety in Health Care - September 16, 2014 Category: Health Management Authors: Profit, J., Sharek, P. J., Amspoker, A. B., Kowalkowski, M. A., Nisbet, C. C., Thomas, E. J., Chadwick, W. A., Sexton, J. B. Tags: Original research Source Type: research

Processive SARS-CoV RNA polymerase complex [Microbiology]
In addition to members causing milder human infections, the Coronaviridae family includes potentially lethal zoonotic agents causing severe acute respiratory syndrome (SARS) and the recently emerged Middle East respiratory syndrome. The ∼30-kb positive-stranded RNA genome of coronaviruses encodes a replication/transcription machinery that is unusually complex and composed of 16 nonstructural... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - September 16, 2014 Category: Science Authors: Subissi, L., Posthuma, C. C., Collet, A., Zevenhoven-Dobbe, J. C., Gorbalenya, A. E., Decroly, E., Snijder, E. J., Canard, B., Imbert, I. Tags: PNAS Plus Source Type: research

Health risk and significance of mercury in the environment.
Abstract Mercury (Hg) has long been recognised as a global pollutant, because it can remain in the atmosphere for more than 1 year. The mercury that enters the environment is generally acknowledged to have two sources: natural and anthropogenic. Hg takes three major forms in the environment, namely methyl-Hg (MeHg), Hg(0) and Hg(2+). All three forms of Hg adversely affect the natural environment and pose a risk to human health. In particular, they may damage the human central nervous system, leading to cardiovascular, respiratory and other diseases. MeHg is bioavailable and can be bioaccumulated within food webs. ...
Source: Environmental Science and Pollution Research International - September 16, 2014 Category: Environmental Health Authors: Li WC, Tse HF Tags: Environ Sci Pollut Res Int Source Type: research

Diagnostic Concordance of Echocardiography and Cardiac Magnetic Resonance-Based Tissue Tracking for Differentiating Constrictive Pericarditis From Restrictive Cardiomyopathy [Pericardial Disease]
Conclusions— CMR and echocardiography tissue tracking–derived left ventricular mechanics provide comparable diagnostic information for differentiating CP from RCM. (Source: Circulation: Cardiovascular Imaging)
Source: Circulation: Cardiovascular Imaging - September 16, 2014 Category: Radiology Authors: Amaki, M., Savino, J., Ain, D. L., Sanz, J., Pedrizzetti, G., Kulkarni, H., Narula, J., Sengupta, P. P. Tags: Pericardial disease, Cardiovascular imaging agents/Techniques, Echocardiography Source Type: research

Blood oxygen equilibration time after cessation of supplemental oxygen in chronic respiratory disease
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - September 16, 2014 Category: Internal Medicine Authors: Stone AMC, Wong KKH, Barnes DJ Tags: Original Article Source Type: research

Asymptomatic HIV-infected Individuals on Antiretroviral Therapy Exhibit Impaired Lung CD4(+) T Cell Responses to Mycobacteria.
Conclusion. AM and mycobacteria-specific alveolar CD4+ T cell responses in HIV-infected adults on ART for <4 years are impaired and may partly explain the high risk of TB in HIV-infected individuals on ART. Strategies to augment ART to improve lung immune cell function and reduce the high incidence of TB in HIV-infected adults who initiate ART should be investigated. PMID: 25225948 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - September 16, 2014 Category: Respiratory Medicine Authors: Jambo KC, Banda DH, Afran L, Kankwatira AM, Malamba RD, Allain TJ, Gordon SB, Heyderman RS, Russell DG, Mwandumba HC Tags: Am J Respir Crit Care Med Source Type: research

View from the front lines: An emergency medicine perspective on clostridial infections in injection drug users.
Abstract Injection drug use (IDU), specifically non-intravenous "skin-popping" of heroin, seems to provide optimal conditions for Clostridial infection and toxin production. IDU is therefore a major risk factor for wound botulism and Clostridial necrotizing soft tissue infections (NSTI) and continues to be linked to cases of tetanus. Case clusters of all 3 diseases have occurred among IDUs in Western U.S. and Europe. Medical personnel who care for the IDU population must be thoroughly familiar with the clinical presentation and management of these diseases. Wound botulism presents with bulbar symptoms and signs tha...
Source: Anaerobe - September 16, 2014 Category: Microbiology Authors: Gonzales Y Tucker RD, Frazee B Tags: Anaerobe Source Type: research

Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma
Conclusions: S-1226 is a potent and rapid formulation for re-opening constricted airways. Its mechanism(s) of action are unknown. The formulation has potential as a rescue treatment for acute severe asthma. (Source: Respiratory Research)
Source: Respiratory Research - September 16, 2014 Category: Respiratory Medicine Authors: Tamer El MaysParichita ChoudhuryRichard LeighEmmanuel KoumoundourosJoanne Van der VeldenGrishma ShresthaCora PieronJohn DennisFrancis GreenKen Snibson Source Type: research

Increased ILC2s in the eosinophilic nasal polyp endotype are associated with corticosteroid responsiveness.
Abstract Type 2 innate lymphoid cells (ILC2s) have recently been identified in human nasal polyps, but whether numbers of ILC2s differ by polyp endotype or are influenced by corticosteroid use is unknown. Here, we show that eosinophilic nasal polyps contained double the number of ILC2s vs. non-eosinophilic polyps. Polyp ILC2s were also reduced by 50% in patients treated with systemic corticosteroids. Further, using a fungal allergen challenge mouse model, we detected greatly reduced Th2 cytokine-producing and Ki-67+ proliferating lung ILC2s in mice receiving dexamethasone. Finally, ILC2 Annexin V staining revealed ...
Source: Clinical Immunology - September 16, 2014 Category: Allergy & Immunology Authors: Walford HH, Lund SJ, Baum RE, White AA, Bergeron CM, Husseman J, Bethel KJ, Scott DR, Khorram N, Miller M, Broide DH, Doherty TA Tags: Clin Immunol Source Type: research

Assessing Variability in the Impacts of Heat on Health Outcomes in New York City Over Time, Season, and Heat-Wave Duration
Abstract While the impacts of heat upon mortality and morbidity have been frequently studied, few studies have examined the relationship between heat, morbidity, and mortality across the same events. This research assesses the relationship between heat events and morbidity and mortality in New York City for the period 1991–2004. Heat events are defined based on oppressive weather types as determined by the Spatial Synoptic Classification. Morbidity data include hospitalizations for heat-related, respiratory, and cardiovascular causes; mortality data include these subsets as well as all-cause totals. Distributed-...
Source: EcoHealth - September 16, 2014 Category: Environmental Health Source Type: research

An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing
Conclusions These preliminary findings support an automated way to process EEG artefacts during sleep, providing the opportunity to investigate EEG-based markers of neurobehavioural impairment in sleep disorders in future studies. (Source: Sleep and Breathing)
Source: Sleep and Breathing - September 16, 2014 Category: Respiratory Medicine Source Type: research