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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.

Post-disaster health impact of natural hazards in the Philippines in 2013.
CONCLUSIONS: Most post-disaster syndromes may be addressed by prevention, early diagnosis, and early treatment. Health needs differ in response and recovery phases. PMID: 27193265 [PubMed - in process] (Source: Global Health Action)
Source: Global Health Action - May 21, 2016 Category: Global & Universal Tags: Glob Health Action Source Type: research

Human coronavirus and severe acute respiratory infection in Southern Brazil.
This study aimed to analyze the impact of HCoV infections and their relation to severe acute respiratory infection (SARI) in a hospitalized population in Southern Brazil. A cross-sectional study was conducted at a tertiary care hospital, and assessed inpatients under investigation for SARI by the hospital epidemiology department, and all patients who had nasopharyngeal aspirates collected from January 2012 to December 2013 to detect respiratory viruses (RVs). Viral infection was detected by multiplex reverse transcriptase polymerase chain reaction (RT-PCR), with primers specific to the subtypes HCoV-229E/NL63 and OC43/HKU1...
Source: Pathogens and Global Health - May 21, 2016 Category: Global & Universal Tags: Pathog Glob Health Source Type: research

Low-intensity exercise in the acute phase of lipopolysaccharide-induced sepsis improves lipid metabolism and survival in mice by stimulating PGC-1α expression
CONCLUSION: Our study provides the revolutionary finding that exercise during the acute phase following sepsis onset might exert a therapeutic effect. (Source: The Journal of Trauma: Injury, Infection, and Critical Care)
Source: The Journal of Trauma: Injury, Infection, and Critical Care - May 21, 2016 Category: Orthopaedics Tags: AAST 2015 Plenary Papers Source Type: research

Safety of minimizing preoperative starvation in critically ill and intubated trauma patients
CONCLUSIONS: Allowing intubated trauma patients to continue enteral nutrition until transfer for operations or procedures was associated with increased caloric intake without evidence of increased pulmonary complications. This represents an important strategy to reduce calorie deficits in the trauma intensive care unit. Level of Evidence: Therapeutic study/care management, level III. (Source: The Journal of Trauma: Injury, Infection, and Critical Care)
Source: The Journal of Trauma: Injury, Infection, and Critical Care - May 21, 2016 Category: Orthopaedics Tags: Original Articles Source Type: research

The acute respiratory distress syndrome following isolated severe traumatic brain injury
CONCLUSION: In the era of balanced hemostatic resuscitation practices, severity of head injury, male sex, early crystalloids, and early transfusion of platelets are associated with a higher risk of ARDS after severe isolated TBI. Early transfusion of platelets after severe TBI may be a modifiable risk factor for ARDS, and these findings invite further investigation into causal mechanisms driving this observed association. LEVEL OF EVIDENCE: Prognostic/epidemiologic study, level III. (Source: The Journal of Trauma: Injury, Infection, and Critical Care)
Source: The Journal of Trauma: Injury, Infection, and Critical Care - May 21, 2016 Category: Orthopaedics Tags: Original Articles Source Type: research

VATS lobectomy program: the trainee perspective.
Authors: Sandri A, Filosso PL, Lausi PO, Ruffini E, Oliaro A Abstract Due to its intrinsic characteristics, video assisted thoracic surgery (VATS) lobectomy is currently the recommended surgical approach for early stage lung cancer treatment. The importance of increasing the number of surgeons capable of performing VATS lobectomies is implicit and of utmost importance. In fact, the need of performing independently and routinely VATS lobectomies for early stage lung cancer will soon be a prerequisite to the new generation of thoracic surgeons. The feeling that VATS lobectomy teaching should be part of their training...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Opportunities and challenges for thoracic surgery collaborations in China: a commentary.
Authors: Sihoe AD Abstract Through a unique combination of factors-including a huge population, rapid social development, and concentration of resources in its mega-cities-China is witnessing phenomenal developments in the field of thoracic surgery. Ultra-high-volume centers are emerging that provide fantastic new opportunities for surgical training and clinical research to surgeons in China and partners from other countries. However, there are also particular shortcomings that are limiting clinical and academic developments. To realize the potential and reap the rewards, the challenges posed by these limitations m...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Minimally invasive (robotic assisted thoracic surgery and video-assisted thoracic surgery) lobectomy for the treatment of locally advanced non-small cell lung cancer.
CONCLUSIONS: In appropriately selected patients with NSCLC, MIS approaches to lobectomy following induction therapy are feasible and associated with similar disease-free and OS to those following thoracotomy. PMID: 27195138 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Surgery versus stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer: less is not more.
Authors: White A, Swanson SJ Abstract High level evidence from randomized studies comparing surgery to stereotactic ablative radiotherapy (SABR) is lacking and available retrospective cohort and case control studies are highly variable in how thoroughly they define and stage lung cancer, in how they determine operability, and in the offered surgical approaches to operable lung cancer (open vs. video-assisted). This makes it difficult to compare best radiotherapy and best surgery approaches to treatment and to be confident in conclusions of equipoise between the two modalities. What has become clear from the controv...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

European perspective in Thoracic surgery-eso-coloplasty: when and how?
Authors: Gust L, Ouattara M, Coosemans W, Nafteux P, Thomas PA, D'Journo XB Abstract Colon interposition has been used since the beginning of the 20(th) century as a substitute for esophageal replacement. Colon interposition is mainly chosen as a second line treatment when the stomach cannot be used, when the stomach has to be resected for oncological or technical reasons, or when the stomach is deliberately kept intact for benign diseases in young patients with long-life expectancy. During the surgery the vascularization of the colon must be carefully assessed, as well as the type of the graft (right or left colon...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Diaphragm pacing: the state of the art.
Authors: Le Pimpec-Barthes F, Legras A, Arame A, Pricopi C, Boucherie JC, Badia A, Panzini CM Abstract Diaphragm pacing (DP) is an orphan surgical procedure that may be proposed in strictly selected ventilator-dependent patients to get an active diaphragm contraction. The goal is to wean from mechanical ventilation (MV) and restore permanent efficient breathing. The two validated indications, despite the lack of randomised control trials, concern patients with high-level spinal cord injuries (SCI) and central hypoventilation syndromes (CHS). To date, two different techniques exist. The first, intrathoracic diaphrag...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Non-intubated video-assisted thoracic surgery: where does evidence stand?
Authors: Tacconi F, Pompeo E Abstract In recent years, non-intubated video-assisted thoracic surgery (NIVATS) strategies are gaining popularity worldwide. The main goal of this surgical practice is to achieve an overall improvement of patients' management and outcome thanks to the avoidance of side-effects related to general anesthesia (GA) and one-lung ventilation. The spectrum of expected benefits is multifaceted and includes reduced postoperative morbidity, faster discharge, decreased hospital costs and a globally reduced perturbation of patients' well-being status. We have conducted a literature search to evalu...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Vascular access for extracorporeal life support: tips and tricks.
The objective of this review is to describe the rational of the different ECLS techniques used in thoracic surgery and lung transplantation (LTx) with a specific attention to the vascular access. Venovenous extracorporeal membrane oxygenation (VV ECMO) is the most common ECLS technique used in thoracic surgery and represents the best strategy to support the lung function. VV ECMO needs peripheral vascular access. The selection between his double-site or single-site configuration should be decided according the level of O2 requirements, the nosological context, and the interest to perform an ECLS ambulatory strategy. Venoar...
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Preface to the 3(rd) European Perspective in Thoracic Surgery special issue.
Authors: Brunelli A, Ruffini E PMID: 27195132 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - May 21, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Sedation and Analgesia in Transportation of Acutely and Critically Ill Patients
This article describes common challenges in providing sedation and analgesia during various phases of transport. (Source: Critical Care Nursing Clinics of North America)
Source: Critical Care Nursing Clinics of North America - May 21, 2016 Category: Nursing Authors: Dawn Johnston, Kevin Franklin, Paul Rigby, Karen Bergman, Scott B. Davidson Source Type: research

Incidence, survival and cause-specific mortality in alcoholic liver disease: a population-based cohort study.
CONCLUSIONS: The incidence of AH and alcoholic liver cirrhosis is increasing. The survival is poor. Most deaths are alcohol-related and other common causes of excess deaths are cancers especially in the upper aerodigestive tract and cardiovascular, digestive and respiratory diseases as well as violence and accidents. PMID: 27181618 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Gastroenterology)
Source: Scandinavian Journal of Gastroenterology - May 21, 2016 Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research

Early Bubble Continuous Positive Airway Pressure: Investigating Interprofessional Best Practices for the NICU Team.
Abstract Premature neonates delivered <32 completed weeks gestation are unprepared to handle the physiologic demands of extrauterine life. Within the respiratory system, alveolar instability and collapse can cause decreased functional residual capacity, impaired oxygenation, and hypoxemia leading to respiratory distress syndrome. Supportive measures are indicated immediately after birth to establish physiologic stability including bubble continuous positive airway pressure (CPAP) or endotracheal intubation and mechanical ventilation. CPAP is a noninvasive, gentle mode of ventilation that can mitigate the effects...
Source: Neonatal Network - May 21, 2016 Category: Perinatology & Neonatology Authors: Casey JL, Newberry D, Jnah A Tags: Neonatal Netw Source Type: research

Evaluation of case definitions to detect respiratory syncytial virus infection in hospitalized children below 5 years in Rural Western Kenya, 2009–2013
In order to better understand respiratory syncytial virus (RSV) epidemiology and burden in tropical Africa, optimal case definitions for detection of RSV cases need to be identified. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 21, 2016 Category: Infectious Diseases Authors: Bryan O. Nyawanda, Joshua A. Mott, Henry N. Njuguna, Lilian Mayieka, Sammy Khagayi, Reuben Onkoba, Caroline Makokha, Nancy A. Otieno, Godfrey M. Bigogo, Mark A. Katz, Daniel R. Feikin and Jennifer R. Verani Source Type: research

Severe maternal morbidity due to respiratory disease and impact of 2009 H1N1 influenza A pandemic in Brazil: results from a national multicenter cross-sectional study
The aim of this study was to assess the burden of respiratory disease, considering the influenza A pandemic season (H1N1pdm09), within the Brazilian Network for Surveillance of Severe Maternal Morbidity, and f... (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - May 21, 2016 Category: Infectious Diseases Authors: L. C. Pfitscher, J. G. Cecatti, R. C. Pacagnella, S. M. Haddad, M. A. Parpinelli, J. P. Souza, S. M. Quintana, F. G. Surita, M. H. Sousa and M. L. Costa Source Type: research

Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome
Conclusions The HDL level was significantly lower in OSAHS patients. The decrease in serum ApoM and ApoA5 in OSAHS patients was correlated to the severity of OSAHS and HDL levels. Auto-continuous positive airway pressure treatment increased serum levels of ApoM, ApoA5, and HDL in OSAHS patients. (Source: Sleep and Breathing)
Source: Sleep and Breathing - May 21, 2016 Category: Respiratory Medicine Source Type: research

Downregulation of the cough reflex by aclidinium and tiotropium in awake and anesthetized rabbits
Publication date: June 2016 Source:Pulmonary Pharmacology &amp; Therapeutics, Volume 38 Author(s): Donatella Mutolo, Elenia Cinelli, Ludovica Iovino, Tito Pantaleo, Fulvia Bongianni Long-acting muscarinic receptor antagonists (LAMAs) have been reported to attenuate cough in preclinical and clinical studies. The present study was performed on rabbits to compare aclidinium and tiotropium efficacy in the downregulation of the cough reflex. This reflex was evoked by citric acid inhalation in unanesthetized animals and by both citric acid inhalation and mechanical stimulation of the tracheobronchial tree in anestheti...
Source: Pulmonary Pharmacology and Therapeutics - May 21, 2016 Category: Respiratory Medicine Source Type: research

Bronchodilator treatment for COPD in primary care of four Latin America countries: The multinational, cross-sectional, non-interventional PUMA study
Conclusions Up to 60% of COPD patients by spirometry and 10% of those with prior medical diagnosis attending a primary care sample of four Latin American countries did not use BDs. LA-BDs are widely underused on a regular-basis (2.6% and 8.3% of patients with spirometric and medical-diagnosis, respectively) This represents a considerable gap between guideline recommendations and BD prescribing pattern in these centres. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 21, 2016 Category: Respiratory Medicine Source Type: research

A novel dissociative steroid VBP15 reduces MUC5AC gene expression in airway epithelial cells but lacks the GRE mediated transcriptional properties of dexamethasone
Publication date: June 2016 Source:Pulmonary Pharmacology &amp; Therapeutics, Volume 38 Author(s): Lindsay M. Garvin, Yajun Chen, Jesse M. Damsker, Mary C. Rose Overproduction of secretory mucins contributes to morbidity/mortality in inflammatory lung diseases. Inflammatory mediators directly increase expression of mucin genes, but few drugs have been shown to directly repress mucin gene expression. IL-1β upregulates the MUC5AC mucin gene in part via the transcription factors NFκB while the glucocorticoid Dexamethasone (Dex) transcriptionally represses MUC5AC expression by Dex-activated GR binding to two GRE ci...
Source: Pulmonary Pharmacology and Therapeutics - May 21, 2016 Category: Respiratory Medicine Source Type: research

Mitigation of tight junction protein dysfunction in lung microvascular endothelial cells with pitavastatin
Conclusion Our results indicate that the maintenance of lung microvascular endothelial cells by pitavastatin prevents tight junction protein dysfunctions induced by CS. These findings may ultimately lead to new and novel therapeutic targets for patients with COPD. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - May 21, 2016 Category: Respiratory Medicine Source Type: research

34th European Society for Paediatric Infectious Diseases annual meeting
Publication date: Available online 20 May 2016 Source:The Lancet Respiratory Medicine Author(s): Christina Waymann (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - May 21, 2016 Category: Respiratory Medicine Source Type: research

Production and immunogenicity of Actinobacillus pleuropneumoniae ApxIIA protein in transgenic rice callus
Publication date: Available online 20 May 2016 Source:Protein Expression and Purification Author(s): Mi-Young Kim, Tae-Geum Kim, Moon-Sik Yang Actinobacillus pleuropneumoniae is a major etiological agent that is responsible for swine pleuropneumonia, a highly contagious respiratory infection that causes severe economic losses in the swine production industry. ApxIIA is one of the virulence factors in A. pleuropneumoniae and has been considered as a candidate for developing a vaccine against the bacterial infection. A gene encoding an ApxIIA fragment (amino acids 439–801) was modified based on a plant-optimized codon...
Source: Protein Expression and Purification - May 21, 2016 Category: Biochemistry Source Type: research

Comparative study between transdermal fentanyl and melatonin patches on postoperative pain relief after lumber laminectomy, a double-blind, placebo-controlled trial
Conclusion The use of preoperative TDF 50μg/h or TDM 7mg was an effective and a safe adjuvant for acute pain after surgery. (Source: Egyptian Journal of Anaesthesia)
Source: Egyptian Journal of Anaesthesia - May 21, 2016 Category: Anesthesiology Source Type: research

Prevalence and management of Recurrent Respiratory Papillomatosis (RRP) in the UK: cross sectional study
ConclusionsThe numbers of RRP patients and Coblation procedures identified in England from a cross‐sectional survey and HES were in broad agreement. Our study estimated 1.42 RRP patients per 100,000 in the general UK population. We also estimated that Coblation procedures accounted for 3% of interventional treatments conducted in the UK RRP population.This article is protected by copyright. All rights reserved. (Source: Clinical Otolaryngology)
Source: Clinical Otolaryngology - May 21, 2016 Category: ENT & OMF Authors: Adam Donne, Kim Keltie, Helen Cole, Andrew Sims, Hannah Patrick, Steve Powell Tags: Original Article Source Type: research

Neonatal metabolic acidosis at birth: In search of a reliable marker
Conclusion Birth-related neonatal eucapnic pH is described as the most pertinent marker of NMA at birth. The various means of calculating this value and the level below which it seems to play a possible pathogenic role are presented. (Source: Gynecologie Obstetrique and Fertilite)
Source: Gynecologie Obstetrique and Fertilite - May 21, 2016 Category: OBGYN Source Type: research

Pulmonary function tests correlated with thoracic volumes in adolescent idiopathic scoliosis
This article is protected by copyright. All rights reserved (Source: Journal of Orthopaedic Research)
Source: Journal of Orthopaedic Research - May 21, 2016 Category: Orthopaedics Authors: Charles G.T. Ledonio, Benjamin E. Rosenstein, David W. Polly, Charles E. Johnston, Warren E. Regelmann, David J. Nuckley Tags: Special Issue Research Article Source Type: research

Effect of exercise training on sleep apnea: A systematic review and meta-analysis
Obstructive sleep apnea (OSA) is difficult to manage for those who are intolerant or noncompliant with standard facial mask treatment options. Current treatment options do not address the underlying cause of OSA. Exercise as a treatment option has been found to improve OSA indices. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - May 21, 2016 Category: Respiratory Medicine Authors: Kenneth D. Aiello, William G. Caughey, Bhargava Nelluri, Ashwini Sharma, Farouk Mookadam, Martina Mookadam Source Type: research

Pulmonary tuberculosis: Resistance pattern to first line anti-tuberculosis drugs in the Coimbra District, 2000–2011
Publication date: Available online 20 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): R. Eufrásio, M. Alcobia, L. Correia (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - May 21, 2016 Category: Respiratory Medicine Source Type: research

Asthma prevalence in Portuguese preschool children: The latest scientific evidence
Publication date: Available online 20 May 2016 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): P.T.B.S. Branco, R.A.O. Nunes, M.C.M. Alvim-Ferraz, F.G. Martins, C. Ferraz, L.G. Vaz, S.I.V. Sousa (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - May 21, 2016 Category: Respiratory Medicine Source Type: research

Altered gene expression in the lower respiratory tract of Car6 (-/-) mice.
In this study, the transcriptional effects of CA VI deficiency were investigated in both trachea and lung of Car6 (-/-) mice using a cDNA microarray analysis. Functional clustering of the results indicated significant changes of gene transcription in the lower airways. The altered biological processes included antigen transport by M-cells, potassium transport, muscle contraction, and thyroid hormone synthesis. Immunohistochemical staining confirmed the absence of CA VI in the submandibular gland of Car6 (-/-) mice. Immunostaining of the trachea and lung samples revealed no differences between the knockout and wild type gro...
Source: Transgenic Research - May 21, 2016 Category: Genetics & Stem Cells Authors: Patrikainen MS, Pan P, Barker HR, Parkkila S Tags: Transgenic Res Source Type: research

Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment.
Abstract In 2010, the World Health Organization (WHO) established an indoor air quality guideline for short- and long-term exposures to formaldehyde (FA) of 0.1 mg/m(3) (0.08 ppm) for all 30-min periods at lifelong exposure. This guideline was supported by studies from 2010 to 2013. Since 2013, new key studies have been published and key cancer cohorts have been updated, which we have evaluated and compared with the WHO guideline. FA is genotoxic, causing DNA adduct formation, and has a clastogenic effect; exposure-response relationships were nonlinear. Relevant genetic polymorphisms were not identified. Normal i...
Source: Archives of Toxicology - May 21, 2016 Category: Toxicology Authors: Nielsen GD, Larsen ST, Wolkoff P Tags: Arch Toxicol Source Type: research

Gas Exchange Models for a Flexible Insect Tracheal System.
Abstract In this paper two models for movement of respiratory gases in the insect trachea are presented. One model considers the tracheal system as a single flexible compartment while the other model considers the trachea as a single flexible compartment with gas exchange. This work represents an extension of Ben-Tal's work on compartmental gas exchange in human lungs and is applied to the insect tracheal system. The purpose of the work is to study nonlinear phenomena seen in the insect respiratory system. It is assumed that the flow inside the trachea is laminar, and that the air inside the chamber behaves as an i...
Source: Acta Biotheoretica - May 21, 2016 Category: Biomedical Science Authors: Simelane SM, Abelman S, Duncan FD Tags: Acta Biotheor Source Type: research

Geographic accessibility of pulmonologists for adults with chronic obstructive pulmonary disease: United States, 2013.
CONCLUSIONS: County-level geographic variations in pulmonologist access for adults with COPD suggest that those adults with limited access will have to depend upon care from primary care physicians. PMID: 27221645 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - May 21, 2016 Category: Respiratory Medicine Authors: Croft JB, Lu H, Zhang X, Holt JB Tags: Chest Source Type: research

Pulmonary Disease Caused by Non-Tuberculous Mycobacteria
We describe the epidemiology of NTM pulmonary disease as well as emerging NTM pathogens and their geographical distribution in non-cystic fibrosis patients in Europe. We also review recent innovations for the diagnosis of NTM pulmonary disease, summarize treatment recommendations, and identify future research priorities to improve the management of patients affected by NTM pulmonary disease.Respiration (Source: Respiration)
Source: Respiration - May 20, 2016 Category: Respiratory Medicine Source Type: research

Applying Adult Ventilator-associated Pneumonia Bundle Evidence to the Ventilated Neonate.
This article describes a VAP prevention protocol developed to address care practices surrounding hand hygiene, intubation, feeding, suctioning, positioning, oral care, and respiratory equipment in the NICU. IMPLICATIONS FOR RESEARCH: Implementation of this VAP prevention protocol in other facilities with appropriate monitoring and tracking would provide broader support for standardization of care. Individual components of this VAP protocol could be studied to strengthen the inclusion of each; however, bundled interventions are often considered stronger when implemented as a whole. PMID: 27195470 [PubMed - as suppli...
Source: Advances in Neonatal Care - May 20, 2016 Category: Nursing Authors: Weber CD Tags: Adv Neonatal Care Source Type: research

[Comment] Respiratory medicine: a call for papers
The Lancet and The Lancet Respiratory Medicine would like to hear from authors of research papers in any area of clinical research related to respiratory medicine and critical care as the two journals are once again planning special issues timed to coincide with the 2016 European Respiratory Society (ERS) International Congress, in London, UK, on Sept 3–7. We welcome high-quality submissions from this thriving research community, particularly clinical trials and research that will change clinical practice or current thinking. (Source: LANCET)
Source: LANCET - May 20, 2016 Category: Journals (General) Authors: Emma Grainger, Sabine Kleinert Tags: Comment Source Type: research

Pulmonary Crohn's Disease in Down Syndrome: A Link or Linkage Problem
We present the case of a 5-year-old girl with known DS and a history of chronic intermittent abdominal pain who presented with persistent pneumonia. Her workup included a chest computed tomography (CT) scan that showed multiple noncalcified pulmonary nodules. An extensive infectious workup was done that was negative. CT-guided needle biopsy of the lung nodules showed necrotizing granulomas. This raised concern for primary CD with extraintestinal pulmonary manifestation. An esophagogastroduodenoscopy and colonoscopy were performed, and colon biopsies showed scattered epithelioid granulomas. Based on this information, there ...
Source: Case Reports in Gastroenterology - May 20, 2016 Category: Gastroenterology Source Type: research

Middle East Respiratory Syndrome Coronavirus Transmission in Extended Family, Saudi Arabia, 2014.
Abstract Risk factors for human-to-human transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) are largely unknown. After MERS-CoV infections occurred in an extended family in Saudi Arabia in 2014, relatives were tested by using real-time reverse transcription PCR (rRT-PCR) and serologic methods. Among 79 relatives, 19 (24%) were MERS-CoV positive; 11 were hospitalized, and 2 died. Eleven (58%) tested positive by rRT-PCR; 8 (42%) tested negative by rRT-PCR but positive by serology. Compared with MERS-CoV-negative adult relatives, MERS-CoV-positive adult relatives were older and more likely to be m...
Source: Emerging Infectious Diseases - May 20, 2016 Category: Infectious Diseases Authors: Arwady MA, Alraddadi B, Basler C, Azhar EI, Abuelzein E, Sindy AI, Sadiq BM, Althaqafi AO, Shabouni O, Banjar A, Haynes LM, Gerber SI, Feikin DR, Madani TA Tags: Emerg Infect Dis Source Type: research

Pediatric perioperative adverse events requiring rapid response: a retrospective case–control study
ConclusionsDecreased age, increased comorbidities, multiple (vs single) surgical services, operating room (vs nonoperating room) location, and decreased staff experience were associated with increased risk of AN! events, which were predominantly respiratory in origin. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - May 20, 2016 Category: Anesthesiology Authors: Laura E. Schleelein, Ariel M. Vincent, Abbas F. Jawad, Eric Y. Pruitt, Genna D. Kreher, Mohamed A. Rehman, Theodora K. Goebel, David E. Cohen, Scott D. Cook‐Sather Tags: Research Report Source Type: research

The Influence of a Dynamic Elastic Garment on Musculoskeletal and Respiratory Wellness in Computer Users.
DISCUSSION: This prospective study demonstrated positive short-term impact of the Posture Shirt® on both subjective and objective measures of posture, lung function, grip strength, fatigue, and productivity. PMID: 27191925 [PubMed - as supplied by publisher] (Source: International Journal of Occupational Safety and Ergonomics)
Source: International Journal of Occupational Safety and Ergonomics - May 20, 2016 Category: Occupational Health Tags: Int J Occup Saf Ergon Source Type: research

Mortality predictors in recipients developing acute respiratory distress syndrome due to pneumonia after kidney transplantation.
CONCLUSION: Infection-related mortality in kidney transplant patients with ARDS was associated with high serum creatinine level and severe ARDS. PMID: 27185552 [PubMed - as supplied by publisher] (Source: Renal Failure)
Source: Renal Failure - May 20, 2016 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

Advancing our understanding of infant bronchiolitis through phenotyping and endotyping: Clinical and molecular approaches.
Authors: Hasegawa K, Dumas O, Hartert TV, Camargo CA Abstract INTRODUCTION: Bronchiolitis is a major public health problem worldwide. However, no effective treatment strategies are available, other than supportive care. Areas Covered: Although bronchiolitis has been considered a single disease diagnosed based on clinical characteristics, emerging evidence supports both clinical and pathobiological heterogeneity. The characterization of this heterogeneity supports the concept that bronchiolitis consists of multiple phenotypes or consistent grouping of characteristics. Expert Commentary: Using unbiased statistical ap...
Source: Expert Review of Respiratory Medicine - May 20, 2016 Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research