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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Notes from the Field: Respiratory Symptoms and Skin Irritation Among Hospital Workers Using a New Disinfection Product - Pennsylvania, 2015.
Abstract In March 2014, a new disinfection product, consisting of hydrogen peroxide, peroxyacetic acid, and acetic acid, was introduced at a Pennsylvania hospital to aid in the control of health care-associated infections. The product is an Environmental Protection Agency-registered non-bleach sporicide advertised as a one-step cleaner, disinfectant, and deodorizer. According to the manufacturer's safety data sheet, the product requires no personal protective equipment when it is diluted with water by an automated dispenser before use. On January 30, 2015, CDC's National Institute for Occupational Health (NIOSH) re...
Source: MMWR Morb Mortal Wkl... - April 22, 2016 Category: Epidemiology Authors: Hawley B, Casey ML, Cox-Ganser JM, Edwards N, Fedan KB, Cummings KJ Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Nasal function and dysfunction in exercise.
CONCLUSION: Nasal dysfunction in exercise may be a source of considerable morbidity to the regular exerciser, and further research into exercise-induced rhinitis is recommended. PMID: 27095550 [PubMed - in process] (Source: Journal of Laryngology and Otology)
Source: Journal of Laryngology and Otology - April 22, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Asian Sand Dust Enhances the Inflammatory Response and Mucin Gene Expression in the Middle Ear.
Conclusion: Environmental ASD exposure can result in the development of otitis media. PMID: 27095518 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Otorhinolaryngology)
Source: Clinical and Experimental Otorhinolaryngology - April 22, 2016 Category: ENT & OMF Tags: Clin Exp Otorhinolaryngol Source Type: research

Continuous Cuffless Blood Pressure Estimation Using Pulse Transit Time and Photoplethysmogram Intensity Ratio
Pulse transit time (PTT) has attracted much interest for cuffless blood pressure (BP) measurement. However, its limited accuracy is one of the main problems preventing its widespread acceptance. Arterial BP oscillates mainly at high frequency (HF) because of respiratory activity, and at low frequency (LF) because of vasomotor tone. Prior studies suggested that PTT can track BP variation in HF range, but was inadequate to follow the LF variation, which is probably the main reason for its unsatisfactory accuracy. This paper presents a new indicator, the photoplethysmogram intensity ratio (PIR), which can be affected by chang...
Source: IEEE Transactions on Biomedical Engineering - April 22, 2016 Category: Biomedical Engineering Source Type: research

Respiratory health outcomes and air pollution in the Eastern Mediterranean Region: a systematic review
Journal Name: Reviews on Environmental HealthIssue: Ahead of print (Source: Reviews on Environmental Health)
Source: Reviews on Environmental Health - April 22, 2016 Category: Environmental Health Source Type: research

Immunotherapy for lung cancer
Abstract Treatment of lung cancer remains a challenge, and lung cancer is still the leading cause of cancer‐related mortality. Immunotherapy has previously failed in lung cancer but has recently emerged as a very effective new therapy, and there is now growing worldwide enthusiasm in cancer immunotherapy. We summarize why immune checkpoint blockade therapies have generated efficacious and durable responses in clinical trials and why this has reignited interest in this field. Cancer vaccines have also been explored in the past with marginal success. Identification of optimal candidate neoantigens may improve cancer vaccin...
Source: Respirology - April 22, 2016 Category: Respiratory Medicine Authors: Antonius Steven, Scott A. Fisher, Bruce W. Robinson, Kwun M. Fong, Nico Van Zandwijk Tags: Invited Review Series: Lung Cancer Practice, Implementing Evidence Around the World Source Type: research

The first reported case of Burkholderia contaminans in patients with cystic fibrosis in Ireland: from the Sargasso Sea to Irish Children
Burkholderia contaminans is an emerging pathogen in the cystic fibrosis (CF) setting. Included in the Burkholderia cepacia complex (Bcc), B. contaminans is a Gram negative, motile, obl... (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - April 22, 2016 Category: Respiratory Medicine Authors: Rachel F. Power, Barry Linnane, Ruth Martin, Noelle Power, Peig Harnett, Brian Casserly, Nuala H. O’Connell and Colum P. Dunne Source Type: research

Using a high‐flow nasal cannula provided superior results to low‐flow oxygen delivery in moderate to severe bronchiolitis
ConclusionsHFNC provided superior clinical outcomes for infants under 12 months with moderate to severe bronchiolitis compared to low‐flow oxygen.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - April 22, 2016 Category: Pediatrics Authors: Gregorio P. Milani, Anna M. Plebani, Elisa Arturi, Danila Brusa, Susanna Esposito, Laura Dell'Era, Emanuela A. Laicini, Dario Consonni, Carlo Agostoni, Emilio F. Fossali Tags: Regular Article Source Type: research

Inspiratory Muscle Training in Late-Onset Pompe Disease: The Effects on Pulmonary Function Tests, Quality of Life, and Sleep Quality
Conclusion These results suggest that IMT has a positive effect on maximum inspiratory pressure in subjects with LOPD who are under ERT. (Source: Lung)
Source: Lung - April 22, 2016 Category: Respiratory Medicine Source Type: research

Evaluation of children with cystic fibrosis by impulse oscillometry when stable and at exacerbation
ConclusionsIOS may be useful to evaluate pulmonary functions and detect acute exacerbations in CF patients. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 22, 2016 Category: Respiratory Medicine Authors: Ayfer Sakarya, Zeynep S. Uyan, Canan Baydemir, Yonca Anık, Ela Erdem, Yasemin Gokdemir, Bulent Karadag, Fazilet Karakoc, Refika Ersu Tags: Original Article: Cystic Fibrosis Source Type: research

Pediatric pulmonology year in review 2015: Part 3
Summary Our journal covers a broad range of research and scholarly topics related to children's respiratory disorders. For updated perspectives on the rapidly expanding knowledge in our field, we will summarize the past year's publications in our major topic areas, as well as selected publications in these areas from the core clinical journal literature outside our own pages. The current review (Part 3) covers articles on asthma, diagnostic testing/endoscopy, respiratory complications of neuromuscular disorders, and rare lung diseases. Pediatr Pulmonol.. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 22, 2016 Category: Respiratory Medicine Authors: David J. Birnkrant, Ozge Yilmaz, Thomas Nicolai, Jane B. Black, Maroun J. Mhanna, Terry L. Noah Tags: Review Source Type: research

Sputum–plasma ratio of soluble receptor for advanced glycation end-products in patients with chronic obstructive pulmonary disease
Conclusions sRAGE level either in induced sputum, plasma or sputum plasma ratio is not significantly different between stable COPD patients, smokers and healthy controls. Thus, sRAGE cannot be considered as a marker of either diagnosis or severity of COPD. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 22, 2016 Category: Respiratory Medicine Source Type: research

Chondrosarcoma of right 1st rib presenting as neurogenic thoracic outlet syndrome; A 13th case report in world literature
We report a case of chondrosarcoma of right 1st rib causing neurogenic TOS that was resected via posterolateral thoracotomy and biopsy confirmed a grade I chondrosarcoma. In the treatment of chondrosarcoma, chemotherapy and radiotherapy are less effective, and appropriate surgery is needed. (Source: Egyptian Journal of Chest Diseases and Tuberculosis)
Source: Egyptian Journal of Chest Diseases and Tuberculosis - April 22, 2016 Category: Respiratory Medicine Source Type: research

26th European Congress of Clinical Microbiology and Infectious Diseases
Publication date: Available online 21 April 2016 Source:The Lancet Respiratory Medicine Author(s): Rebecca Akkermans (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 22, 2016 Category: Respiratory Medicine Source Type: research

Aetiology of childhood pneumonia in a well vaccinated South African birth cohort: a nested case-control study of the Drakenstein Child Health Study
Publication date: Available online 21 April 2016 Source:The Lancet Respiratory Medicine Author(s): Heather J Zar, Whitney Barnett, Attie Stadler, Sugnet Gardner-Lubbe, Landon Myer, Mark P Nicol Background Pneumonia is a leading cause of mortality and morbidity in children globally. The cause of pneumonia after introduction of the 13-valent pneumococcal conjugate vaccine (PCV13) has not been well studied in low-income and middle-income countries, and most data are from cross-sectional studies of children admitted to hospital. We aimed to longitudinally investigate the incidence and causes of childhood pneumonia in a...
Source: The Lancet Respiratory Medicine - April 22, 2016 Category: Respiratory Medicine Source Type: research

Establishment of childhood pneumonia cause in the era of pneumococcal conjugate vaccines
Publication date: Available online 21 April 2016 Source:The Lancet Respiratory Medicine Author(s): Samuel Rhedin (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - April 22, 2016 Category: Respiratory Medicine Source Type: research

Characteristics of AChR antibody‐negative myasthenia gravis in a South African cohort
Conclusions: Individuals with African genetic ancestry and severe bulbar/respiratory AChR antibody‐negative MG are likely to have MuSK‐MG, but most respond favorably to maintenance immunotherapies. This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - April 22, 2016 Category: Internal Medicine Authors: Saif Huda, Mark R. Woodhall, Angela Vincent, Jeannine M. Heckmann Tags: Research Article Source Type: research

Respiratory system involvement in Costello syndrome
Costello syndrome (CS) is a multisystem disorder caused by heterozygous germline mutations in the HRAS proto‐oncogene. Respiratory system complications have been reported in individuals with CS, but a comprehensive description of the full spectrum and incidence of respiratory symptoms in these patients is not available. Here, we report the clinical course of four CS patients with respiratory complications as a major cause of morbidity. Review of the literature identified 56 CS patients with descriptions of their neonatal course and 17 patients in childhood/adulthood. We found that in the neonatal period, respiratory comp...
Source: American Journal of Medical Genetics Part A - April 22, 2016 Category: Genetics & Stem Cells Authors: Natalia Gomez‐Ospina, Christin Kuo, Amitha Lakshmi Ananth, Angela Myers, Marie‐Luise Brennan, David A. Stevenson, Jonathan A. Bernstein, Louanne Hudgins Tags: Original Article Source Type: research

PcrAB Is Specialized for Scarce Perchlorate [Protein Structure and Folding]
Perchlorate is an important ion on both Earth and Mars. Perchlorate reductase (PcrAB), a specialized member of the dimethylsulfoxide reductase superfamily, catalyzes the first step of microbial perchlorate respiration, but little is known about the biochemistry, specificity, structure, and mechanism of PcrAB. Here we characterize the biophysics and phylogeny of this enzyme and report the 1.86-Å resolution PcrAB complex crystal structure. Biochemical analysis revealed a relatively high perchlorate affinity (Km = 6 μm) and a characteristic substrate inhibition compared with the highly similar respiratory nitrate reductase ...
Source: Journal of Biological Chemistry - April 22, 2016 Category: Chemistry Authors: Youngblut, M. D., Tsai, C.-L., Clark, I. C., Carlson, H. K., Maglaqui, A. P., Gau-Pan, P. S., Redford, S. A., Wong, A., Tainer, J. A., Coates, J. D. Tags: Enzymology Source Type: research

Glycopeptide Antibiotics Inhibit Virus Entry [Microbiology]
In this study, via high throughput screening of Food and Drug Administration-approved drugs, we identified that teicoplanin, a glycopeptide antibiotic, potently prevents the entry of Ebola envelope pseudotyped viruses into the cytoplasm. Furthermore, teicoplanin also has an inhibitory effect on transcription- and replication-competent virus-like particles, with an IC50 as low as 330 nm. Comparative analysis further demonstrated that teicoplanin is able to block the entry of Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS) envelope pseudotyped viruses as well. Teicoplanin derivatives such...
Source: Journal of Biological Chemistry - April 22, 2016 Category: Chemistry Authors: Zhou, N., Pan, T., Zhang, J., Li, Q., Zhang, X., Bai, C., Huang, F., Peng, T., , Liu, C., Tao, L., Zhang, H. Tags: Microbiology Source Type: research

The impact of severe lung disease on evidential breath analysis collection
It is a legal requirement to supply a breath analysis sample when requested by Police at roadside checkpoints. The current device requires a 1L sample at 8L·min−1. Court disputes commonly attribute respiratory disease for failure to produce a sample. (Source: Science and Justice)
Source: Science and Justice - April 22, 2016 Category: Forensic Medicine Authors: Leigh M. Seccombe, Peter G. Rogers, Lachlan Buddle, Barbara Karet, Gavina Cossa, Matthew J. Peters, Elizabeth M. Veitch Tags: Emerging research article Source Type: research

A robust approach for ECG-based analysis of cardiopulmonary coupling
Human cardiovascular and respiratory systems interact with each other and present effects of modulation and synchronization [1,2]. The cardiovascular and cardiorespiratory systems are characterized by a complex interplay of several linear and nonlinear subsystems [3]. Analysis of cardiopulmonary coupling (CPC) provides information about the coupling dynamics between the cardiorespiratory systems at different time scales [4], leading to improved knowledge of the interacting regulatory mechanisms under different physiological and pathophysiological conditions [1]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 22, 2016 Category: Biomedical Engineering Authors: Jiewen Zheng, Weidong Wang, Zhengbo Zhang, Dalei Wu, Hao Wu, Chung-kang Peng Tags: Technical note Source Type: research

Comparison of different degrees of variability in tidal volume to prevent deterioration of respiratory system elastance in experimental acute lung inflammation
Conclusions In this model of acute lung inflammation, a VT variability of 30%, compared with 15 and 7.5%, was necessary to avoid deterioration of respiratory system elastance and was not associated with lung histological damage. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - April 22, 2016 Category: Anesthesiology Authors: Kiss, T., Silva, P. L., Huhle, R., Moraes, L., Santos, R. S., Felix, N. S., Santos, C. L., Morales, M. M., Capelozzi, V. L., Kasper, M., Pelosi, P., Gama de Abreu, M., Rocco, P. R. M. Tags: Translational Research Source Type: research

Initial Mechanical Ventilator Settings and Lung Protective Ventilation in the Emergency Department
This study aims to characterize mechanically ventilated patients in the Emergency Department (ED), describe the initial ED ventilator settings, and assess for associations between lung protective ventilation strategies in the ED and outcomes. (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - April 22, 2016 Category: Emergency Medicine Authors: Susan R. Wilcox, Jeremy B. Richards, Daniel F. Fisher, Jeffrey Sankoff, Todd A. Seigel Tags: Original Contribution Source Type: research

Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice [Bacterial Infections]
We present a model of nasal pneumococcal colonization in cigarette smoke-exposed mice and document, for the first time, that cigarette smoke predisposes to invasive pneumococcal infection and mortality in an animal model. Cigarette smoke increased the risk of bacteremia and meningitis without prior lung infection. Mechanistically, deficiency in interleukin 1α (IL-1α) or platelet-activating factor receptor (PAFR), an important host receptor thought to bind and facilitate pneumococcal invasiveness, did not rescue cigarette smoke-exposed mice from invasive pneumococcal disease. Importantly, we observed cigarette s...
Source: Infection and Immunity - April 22, 2016 Category: Infectious Diseases Authors: Shen, P., Morissette, M. C., Vanderstocken, G., Gao, Y., Hassan, M., Roos, A., Thayaparan, D., Merlano, M., Dorrington, M. G., Nikota, J. K., Bauer, C. M. T., Kwiecien, J. M., Labiris, R., Bowdish, D. M. E., Stevenson, C. S., Stämpfli, M. R. Tags: Bacterial Infections Source Type: research

Efficacy of adalimumab in sarcoidosis patients who developed intolerance to infliximab
The objective of this retrospective observational study was to establish if adalimumab could achieve stabilization or improvement of the disease in refractory sarcoidosis patients who developed intolerance to infliximab. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 22, 2016 Category: Respiratory Medicine Authors: Heleen A. Crommelin, Leone M. van der Burg, Adriane D.M. Vorselaars, Marjolein Drent, Coline H.M. van Moorsel, Ger T. Rijkers, Vera H.M. Deneer, Jan C. Grutters Source Type: research

A false positive newborn screening result due to a complex allele carrying two frequent CF-causing variants
The detection of two frequent CFTR disease-causing variations in the context of a newborn screening program (NBS) usually leads to the diagnosis of cystic fibrosis (CF) and a relevant genetic counseling in the family. In the present study, CF-causing variants p.Phe508del (F508del) and c.3140-26A>G (3272-26A>G) were identified on a neonate with positive ImmunoReactive Trypsinogen test by the Elucigene™ CF30 kit. The CF diagnosis initially suggested, despite three inconclusive Sweat Chloride Tests (SCT), was finally ruled out after the familial segregation study combined with a negative SCT. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 22, 2016 Category: Respiratory Medicine Authors: Anne Bergougnoux, Amandine Boureau-Wirth, Cécile Rouzier, Jean-Pierre Altieri, Fanny Verneau, Lise Larrieu, Michel Koenig, Mireille Claustres, Caroline Raynal Tags: Short Communication Source Type: research

Impact of intraoperative cholangiography on postoperative morbidity and readmission: analysis of the NSQIP database
Conclusion The use of IOC at the time of LC appears to be associated with a statistically significant decrease in re-admission rates, especially readmissions related to biliary complications. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - April 22, 2016 Category: Surgery Source Type: research

Multimorbidity in adults from a southern Brazilian city: occurrence and patterns
Conclusions Multimorbidity was common in the studied population. The observed patterns may be used to generate and improve Brazilian diseases guidelines. (Source: International Journal of Public Health)
Source: International Journal of Public Health - April 22, 2016 Category: Global & Universal Source Type: research

The sleepy patient
Sleepiness is a common symptom affecting approximately 10% of the adult population. It is defined as sleep episodes occurring at an inappropriate time or in inappropriate circumstances, such as when reading or driving. Sleepiness is commonly measured using the Epworth Sleepiness Scale. Physiological measures, including the Multiple Sleep Latency Test, are also used to estimate sleepiness. Sleep deprivation or inadequate opportunity to sleep quickly leads to clinically significant excessive sleepiness. (Source: Medicine)
Source: Medicine - April 22, 2016 Category: Internal Medicine Authors: Adrian J. Williams Tags: Respiratory failure Source Type: research

Integrated respiratory care
is patient-centred, proactive and coordinated care delivered through clinical leadership and a multidisciplinary ‘team without walls’. It involves rethinking traditional boundaries and roles, and requires respiratory specialists to develop new skills in the management of long-term conditions and collaborative care. The aim of integrated respiratory care is to enhance the care and experience of the individual patient with a lung condition and to improve outcomes for populations with long-term disease. (Source: Medicine)
Source: Medicine - April 22, 2016 Category: Internal Medicine Authors: Irem Patel Tags: Infection Source Type: research

Respiratory failure
This article reviews the pathophysiology of these perturbations in respiratory homoeostasis, the clinical features of acute and chronic respiratory failure and a brief discussion of the management. (Source: Medicine)
Source: Medicine - April 22, 2016 Category: Internal Medicine Authors: Ben Creagh-Brown Tags: Respiratory failure Source Type: research

Protocol for studying cough frequency in people with pulmonary tuberculosis
This study will select participants with culture confirmed TB from 2 tertiary hospitals in Lima, Peru. We estimated that a sample size of 107 patients was sufficient to detect clinically significant changes in cough frequency. Participants will initially be evaluated through questionnaires, radiology, microscopic observation drug susceptibility broth TB-culture, auramine smear microscopy and cough recordings. This cohort will be followed for the initial 60 days of anti-TB treatment, and throughout the study several microbiological samples as well as 24 h recordings will be collected. We will describe the variabil...
Source: BMJ Open - April 22, 2016 Category: Journals (General) Authors: Proano, A., Bravard, M. A., Tracey, B. H., Lopez, J. W., Comina, G., Zimic, M., Coronel, J., O'Neill Lee, G., Caviedes, L., Luis Cabrera, J., Salas, A., Ticona, E., Kirwan, D. E., Friedland, J. S., Evans, C. A., Moore, D. A., Gilman, R. H., Tuberculosis W Tags: Open access, Global health, Infectious diseases, Respiratory medicine Protocol Source Type: research

Assisted reproductive technology and risk of asthma and allergy in the offspring: protocol for a systematic review and meta-analysis
Introduction The use of assisted reproductive technology (ART) procedures has increased globally over the last three decades. Recent observational studies suggest that children conceived through ART may be at increased risk of asthma and atopic disease compared with children conceived naturally, but findings are mixed. We aim to synthesise the evidence on the impact of ART on the risk of asthma and atopic disease in the offspring. Methods and analysis We will identify relevant studies by searching MEDLINE, EMBASE, Cochrane Library, ISI Web of Science, CINAHL, Scopus, Google Scholar, AMED, Global Health, PsychINFO, CAB Int...
Source: BMJ Open - April 22, 2016 Category: Journals (General) Authors: Nwaru, B. I., McCleary, N., Erkkola, M., Kaila, M., Virtanen, S. M., Sheikh, A. Tags: Open access, Epidemiology, Paediatrics, Public health, Respiratory medicine, Obgyn Protocol Source Type: research

Influence of Lung Function and Sleep-Disordered Breathing on All-Cause Mortality: A Community Based Study.
CONCLUSIONS: Lung function was associated with risk for all-cause mortality. The incremental contribution of lung function to mortality diminishes with increasing severity of SDB. PMID: 27105053 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2016 Category: Respiratory Medicine Authors: Putcha N, Crainiceanu C, Norato G, Samet J, Quan S, Gottlieb DJ, Redline S, Punjabi NM Tags: Am J Respir Crit Care Med Source Type: research

Discovery of Clinically Approved Agents That Promote Suppression of CFTR Nonsense Mutations.
CONCLUSIONS: Clinically approved drugs identified as potential readthrough agents, in combination with ivacaftor, may induce nonsense suppression to restore therapeutic levels of CFTR function. One or more agents may be suitable to advance to human testing. PMID: 27104944 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2016 Category: Respiratory Medicine Authors: Mutyam V, Du M, Xue X, Keeling KM, White EL, Bostwick JR, Rasmussen L, Liu B, Mazur M, Hong JS, Falk Libby E, Liang F, Shang H, Mense M, Suto MJ, Bedwell DM, Rowe SM Tags: Am J Respir Crit Care Med Source Type: research

Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying COPD and IPF.
CONCLUSIONS: Our results suggest convergent transcriptional regulatory hubs in diseases as varied phenotypically as COPD and IPF and suggest that these hubs may represent shared key responses of the lung to environmental stresses. PMID: 27104832 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 22, 2016 Category: Respiratory Medicine Authors: Kusko RL, Brothers Ii JF, Tedrow J, Pandit K, Huleihel L, Perdomo C, Liu G, Juan-Guardela B, Kass D, Zhang S, Lenburg M, Martinez F, Quackenbush J, Sciurba F, Limper A, Geraci M, Yang I, Schwartz DA, Beane J, Spira A, Kaminski N Tags: Am J Respir Crit Care Med Source Type: research

Neutrophil-derived Exosomes: A New Mechanism Contributing to Airway Smooth Muscle Remodeling.
CONCLUSION: Upon stimulation of LPS, neutrophils derived-exosomes can enhance the proliferation of ASM and therefore could play an important role in the progression of asthma and promoting airway remodeling in severe and corticosteroid-insensitive asthmatic patients. PMID: 27105177 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - April 22, 2016 Category: Respiratory Medicine Authors: Vargas A, Roux-Dalvai F, Droit A, Lavoie JP Tags: Am J Respir Cell Mol Biol Source Type: research

Patient selection criteria for outpatient joint arthroplasty
Conclusion Based on the current literature, the presented patient selection criteria provide a basis for outpatient joint arthroplasty and can be useful when selecting patients. Together with a change in mindset, a multidisciplinary approach and literature-based protocols, outpatient joint arthroplasty can be applied in daily orthopaedic practice while ensuring patients’ safety. Level of evidence Clinical review, Level III. (Source: Knee Surgery, Sports Traumatology, Arthroscopy)
Source: Knee Surgery, Sports Traumatology, Arthroscopy - April 22, 2016 Category: Orthopaedics Source Type: research

Antenatal manifestations of inborn errors of metabolism: autopsy findings suggestive of a metabolic disorder
Abstract This review highlights the importance of performing an autopsy when faced with fetal abortion or termination of pregnancy with suspicion of an inborn error of metabolism. Radiological, macroscopic and microscopic features found at autopsy as well as placental anomalies that can suggest such a diagnosis are detailed. The following metabolic disorders encountered in fetuses are discussed: lysosomal storage diseases, peroxisomal disorders, cholesterol synthesis disorders, congenital disorders of glycosylation, glycogenosis type IV, mitochondrial respiratory chain disorders, transaldolase deficiency, generali...
Source: Journal of Inherited Metabolic Disease - April 22, 2016 Category: Internal Medicine Source Type: research

[Lung Function in Childhood and Adolescence: Influence of Prematurity and Bronchopulmonary Dysplasia].
Conclusion: Infants born before 32 weeks of gestational age in the surfactant era still carry an increased risk to suffer an impaired pulmonary function in childhood and adolescence, particularly if they survived with BPD. Long term pulmonary care for these patients should take place in specialized centers. PMID: 27104655 [PubMed - as supplied by publisher] (Source: Zeitschrift fur Geburtshilfe und Neonatologie)
Source: Zeitschrift fur Geburtshilfe und Neonatologie - April 22, 2016 Category: Perinatology & Neonatology Authors: Segerer FJ, Speer CP Tags: Z Geburtshilfe Neonatol Source Type: research