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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.
Magnetic Resonance Imaging Detects Changes in Structure and Perfusion, and Response to Therapy in Early Cystic Fibrosis Lung Disease.
Conclusions: MRI detected abnormalities in lung structure and perfusion, and response to therapy for exacerbations in infants and preschool children with CF. These results support the development of MRI for non-invasive monitoring and as an endpoint in interventional trials for early CF lung disease. PMID: 24564281 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 24, 2014 Category: Respiratory Medicine Authors: Wielpütz MO, Puderbach M, Kopp-Schneider A, Stahl M, Fritzsching E, Sommerburg O, Ley S, Sumkauskaite M, Biederer J, Kauczor HU, Eichinger M, Mall MA Tags: Am J Respir Crit Care Med Source Type: research
Palliative care in children with spinal muscular atrophy type I: What do they need?
Abstract Objective: Our aim was to describe the clinical evolution and needs of children with spinal muscular atrophy type I treated in a domiciliary palliative care program. Method: We undertook a retrospective chart review of nine consecutive patients. Descriptions of the clinical and demographic profile of children with spinal muscular atrophy (SMA) type I were referred to a pediatric palliative care team (PPCT). Results: Six males and three females were admitted to the PPCT, all before six months of age, except for one afflicted with SMA type I with respiratory distress. The median time of attention was 57 days...
Source: Palliative and Supportive Care - February 24, 2014 Category: Palliative Care Authors: García-Salido A, de Paso-Mora MG, Monleón-Luque M, Martino-Alba R Tags: Palliat Support Care Source Type: research
A practical approach to the theoretical models to calculate NO parameters of the respiratory system
Expired nitric oxide (NO) is used as a biomarker in different respiratory diseases. The recommended flow rate of 50 mL s −1 (F E NO 0.05 ) does not reveal from where in the lung NO production originated. Theoretical models of NO transfer from the respiratory system, linear or nonlinear approaches, have therefore been developed and applied. These models can estimate NO from distal lung (alveolar NO) and airways (bronchial flux). The aim of this study was to show the limitation in exhaled flow rate for the theoretical models of NO production in the respiratory system, linear and nonlinear models. Subjects ( n = 32...
Source: Journal of Breath Research - February 24, 2014 Category: Mental Illness Authors: M Högman, A Thornadtsson, G Hedenstierna and P Meriläinen Source Type: research
Modulating Endothelial Barrier Function by Targeting Vimentin Phosphorylation
Vimentin is a major intermediate filament protein in vascular endothelial cells which might be involved in their function as a barrier tissue. It is proposed to dynamically maintain integrity of the endothelium as a tightly regulated permeability barrier that is subjected to a variety of shear and contractile forces. The results described in this report demonstrate that vimentin plays that role through mechanisms that are dependent on its phosphorylation state. Withaferin A (WFA), a vimentin targeting drug is shown to disrupt endothelial barrier function through its effects on vimentin filament distribution and physical pr...
Source: Journal of Cellular Physiology - February 23, 2014 Category: Cytology Authors: Tiegang Liu, Maher M. Ghamloush, Ali Aldawood, Rod Warburton, Deniz Toksoz, Nicholas S. Hill, Dale D. Tang, Usamah S. Kayyali Tags: Original Research Article Source Type: research
Concomitant occurrence of IgG4-related pleuritis and periaortitis: a case report with review of the literature.
Abstract IgG4-related sclerosing disease is an established disease entity with characteristic clinicopathological features. Some recent reports have demonstrated that this disease can occur in the respiratory system including the pleura. Herein, we describe the first documented case of concomitant occurrence of IgG4-related pleuritis and periaortitis. A 71-year-old Japanese female with a history of essential thrombocythemia presented with persistent cough and difficulty in breathing. Computed tomography demonstrated thickening of the right parietal pleura, pericardium, and periaortic tissue and pleural and cardiac ...
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Ishida M, Hodohara K, Furuya A, Fujishiro A, Okuno H, Yoshii M, Horinouchi A, Shirakawa A, Harada A, Iwai M, Yoshida K, Kagotani A, Yoshida T, Okabe H Tags: Int J Clin Exp Pathol Source Type: research
Hepatopulmonary syndrome: the role of intra-abdominal hypertension and a novel mouse model.
CONCLUSIONS: Our study suggested that intra-abdominal hypertension was a significant pathological mechanism of HPS. Meanwhile, we have established a novel mouse model that will now be optimized with further investigation of the mechanism and therapeutic targets of HPS. PMID: 24551301 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Zhang Z, Qi X, Li Z, Xu L, Wang F, Wang S, Chang Y, Ma W, Xu M, Yang C Tags: Int J Clin Exp Pathol Source Type: research
NOX1 is responsible for cell death through STAT3 activation in hyperoxia and is associated with the pathogenesis of Acute Respiratory Distress Syndrome.
This study demonstrates that NOX1 is involved in human ARDS pathophysiology and is responsible for the damage occurring in alveolar epithelial cells at least in part via STAT3 signalling pathways. PMID: 24551274 [PubMed - in process] (Source: International Journal of Clinical and Experimental Pathology)
Source: International Journal of Clinical and Experimental Pathology - February 23, 2014 Category: Pathology Authors: Carnesecchi S, Dunand-Sauthier I, Zanetti F, Singovski G, Deffert C, Donati Y, Cagarelli T, Pache JC, Krause KH, Reith W, Barazzone-Argiroffo C Tags: Int J Clin Exp Pathol Source Type: research
Perfusion index in newborn infants: a noninvasive tool for neonatal monitoring
ConclusionPI is a valuable tool to assess the newborn's health condition and could become a standardised measure in clinical evaluation. Different study designs are necessary to provide further validation to this method. (Source: Acta Paediatrica)
Source: Acta Paediatrica - February 23, 2014 Category: Pediatrics Authors: Carolina Z. Piasek, Frank Van Bel, Augusto Sola Tags: Review Article Source Type: research
Restrictive Lung Involvement in Facioscapulohumeral Muscular Dystrophy
Conclusion: Restrictive respiratory involvement should be considered in all moderate to severely affected FSHD patients with proximal lower extremity weakness. The higher frequency of restrictive lung disease in FSHD2 seen here requires confirmation in a larger cohort of FSHD2 patients. © 2014 Wiley Periodicals, Inc. (Source: Muscle and Nerve)
Source: Muscle and Nerve - February 23, 2014 Category: Internal Medicine Authors: Michele A Scully, Katy J Eichinger, Colleen M Donlin‐Smith, Rabi Tawil, Jeffery M Statland Tags: Research Article Source Type: research
The O2‐sensing TRPA1 channel illustrates the significance of vagal nerves in cardio‐respiratory adaptation to hypoxia
(Source: Acta Physiologica)
Source: Acta Physiologica - February 23, 2014 Category: Physiology Authors: N. Takahashi, Y. Mori Tags: Editorial Source Type: research
Guanosine protects C6 astroglial cells against azide‐induced oxidative damage: a putative role for heme oxygenase 1
This article is protected by copyright. All rights reserved. (Source: Journal of Neurochemistry)
Source: Journal of Neurochemistry - February 23, 2014 Category: Neurology Authors: André Quincozes‐Santos, Larissa Daniele Bobermin, Débora Guerini Souza, Bruna Bellaver, Carlos‐Alberto Gonçalves, Diogo Onofre Souza Tags: Original Article Source Type: research
[Prehospital analgesia performed by paramedics : Quality in processes and effects under medical supervision.]
CONCLUSION: After appropriate training and regular control analgesia administered by paramedics in the present system was safely and effectively applied. PMID: 24562597 [PubMed - as supplied by publisher] (Source: Der Anaesthesist)
Source: Der Anaesthesist - February 23, 2014 Category: Anesthesiology Authors: Häske D, Schempf B, Gaier G, Niederberger C Tags: Anaesthesist Source Type: research
Development of a Respiratory Sensitization/Elicitation Protocol of Toluene Diisocyanate (TDI) in Brown Norway Rats to derive an Elicitation-based Occupational Exposure Level.
Abstract Toluene diisocyanate (TDI), a known human asthmagen, was investigated in skin-sensitized Brown Norway rats for its concentration x time (Cxt)-response relationship on elicitation-based endpoints. The major goal of study was to determine the elicitation inhalation threshold dose in sensitized, re-challenged Brown Norway rats, including the associated variables affecting the dosimetry of inhaled TDI-vapor in rats and as to how these differences can be translated to humans. Attempts were made to duplicate at least some traits of human asthma by using skin-sensitized rats which were subjected to single or mult...
Source: Toxicology - February 23, 2014 Category: Toxicology Authors: Pauluhn J Tags: Toxicology Source Type: research
Eosinophilic pneumonia induced by ceftaroline.
CONCLUSION: A patient with risk factors for respiratory disease developed eosinophilic pneumonia after receiving ceftaroline for the treatment of MRSA pneumonia. Eosinophilia resolved after ceftaroline was discontinued and i.v. methylprednisolone was initiated. PMID: 24534595 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - February 22, 2014 Category: Drugs & Pharmacology Authors: Griffiths CL, Gutierrez KC, Pitt RD, Lovell RD Tags: Am J Health Syst Pharm Source Type: research
Neck circumference percentile: A screening tool for pediatric obstructive sleep apnea
ConclusionsChildren and youth with NC > 95th percentile for age and sex have significantly increased risk of OSA. This effect is significant in males ≥12 years, whereas BMI is not. NC percentile may be an additional screening tool for OSA in children and youth. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - February 22, 2014 Category: Respiratory Medicine Authors: Sherri Katz, Kimmo Murto, Nicholas Barrowman, Janine Clarke, Lynda Hoey, Franco Momoli, Robert Laberge, Jean‐Philippe Vaccani Tags: Original Article: Sleep & Breathing Source Type: research
Case report: passive transfer of hepatitis B antibodies from intravenous immunoglobulin
Conclusion: Misinterpretation of serology results following IVIg infusion may lead to significant patient harm, including unnecessary antiviral administration, the withholding of treatments, and psychosocial damage. This is especially pertinent at a time when we have an ever increasing number of patients being treated with IVIg for a wide array of immune-mediated disease. Passive antibody transfer should be considered wherever unexpected serological changes are identified. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 22, 2014 Category: Infectious Diseases Authors: Simon ParkerEliza GilJessica MansonKatherine WardYasmin ReyalSasha WilsonPatricia Hewitt Source Type: research
Controlled release delivery of penciclovir via a silicone (MED-4750) polymer: kinetics of drug delivery and efficacy in preventing primary feline herpesvirus infection in culture
Conclusions: The clinical deployment of these silicone-penciclovir devices may allow long-term treatment of FHV-1 infection with a single intervention that could last the life of the host cat. (Source: Virology Journal)
Source: Virology Journal - February 22, 2014 Category: Virology Authors: Samantha SemenkowNicole JohnsonDavid MaggsBarry Margulies Source Type: research
Second-Generation Antipsychotics Cause a Rapid Switch to Fat Oxidation That Is Required for Survival in C57BL/6J Mice
Some second-generation antipsychotics (SGAs) increase insulin resistance and fat oxidation, but counter intuitively they do not activate lipolysis. This seems unsustainable for meeting energy demands. Here, we measured dose-dependent effects of SGAs on rates of oxygen consumption (VO2), respiratory exchange ratio (RER), and physical activity in C57BL/6J mice. The role of H1-histamine receptors and consequences of blocking fat oxidation were also examined. Olanzapine, risperidone, and clozapine (2.5–10mg/kg) elicited rapid drops in dark-cycle RER (~0.7) within minutes, whereas aripiprazole exerted only modest changes....
Source: Schizophrenia Bulletin - February 22, 2014 Category: Psychiatry Authors: Klingerman, C. M., Stipanovic, M. E., Bader, M., Lynch, C. J. Tags: Regular Article Source Type: research
In-vitro and in-vivo validation of ethnopharmacological uses of methanol extract of Isodon rugosus Wall. ex Benth (Lamiaceae)
Conclusions: The observed relaxant effect on isolated rabbit jejunum, trachea and aorta preparations caused by Ir.Cr is possibly to be mediated through Ca+2 channel blockade and therefore may provided scientific basis to validate the folkloric uses of the plant in the management of gastrointestinal, respiratory and cardiovascular ailments. The observed antioxidant activity as well as the lipoxygenase inhibitory activity may validate its traditional use in pain and inflammations. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - February 22, 2014 Category: Complementary Medicine Authors: Khalid JanbazJaveria ArifFatima SaqibImran ImranMuhammad AshrafMuhammad Zia-Ul-HaqHawa JaafarVincenzo De Feo Source Type: research
Mechanisms of Pharmaceutical Aerosol Deposition in the Respiratory Tract.
Abstract Aerosol delivery is noninvasive and is effective in much lower doses than required for oral administration. Currently, there are several types of therapeutic aerosol delivery systems, including the pressurized metered-dose inhaler, the dry powder inhaler, the medical nebulizer, the solution mist inhaler, and the nasal sprays. Both oral and nasal inhalation routes are used for the delivery of therapeutic aerosols. Following inhalation therapy, only a fraction of the dose reaches the expected target area. Knowledge of the amount of drug actually deposited is essential in designing the delivery system or devi...
Source: AAPS PharmSciTech - February 22, 2014 Category: Drugs & Pharmacology Authors: Cheng YS Tags: AAPS PharmSciTech Source Type: research
A novel mutation of the transcobalamin II gene in an infant presenting with hemophagocytic lymphohistiocytosis.
Abstract Transcobalamin II (TC II) deficiency is a rare disorder of cobalamin (CBL, vitamin B12) metabolism that occurs due to mutations in transcobalamin gene (TCN2). Hemophagocytic lymphohistiocytosis (HLH) in contrast is a syndrome characterized by uncontrolled immune response with hyperinflammation. A 2-month-old male baby was admitted with complaints of fever, cough, diarrhea, and respiratory distress. The parents were first cousins. The baby exhibited five of the eight diagnostic criteria for HLH-2004 and was diagnosed as HLH. A second bone marrow aspiration demonstrated megaloblastic changes in the erythroid...
Source: International Journal of Hematology - February 22, 2014 Category: Hematology Authors: Unal S, Tezol O, Oztas Y Tags: Int J Hematol Source Type: research
Rothia mucilaginosa Pneumonia in an Immunocompetent Patient.
Abstract Rothia mucilaginosa is a gram-postive coccus that occurs as part of the normal flora of the oropharynx and upper respiratory tract. Lower respiratory tract infections caused by this organism are rare and usually occur in immunocompromised patients. This is the case of an immunocompetent 47-year-old woman with right upper lobe pneumonia in which R.mucilaginosa was isolated in sputum and bronchial aspirate. Infections caused by this agent in the last four years in our hospital were reviewed. The most common predisposing factor was COPD with bronchiectasis. R.mucilaginosa was identified as the causative agent...
Source: Archivos de Bronconeumologia - February 22, 2014 Category: Respiratory Medicine Authors: Baeza Martínez C, Zamora Molina L, García Sevila R, Gil Carbonell J, Ramos Rincon JM, Martín Serrano C Tags: Arch Bronconeumol Source Type: research
Integrated transcriptome analysis across mitochondrial disease etiologies and tissues improves understanding of common cellular adaptations to respiratory chain dysfunction.
Abstract Mitochondrial diseases are heterogeneous, multi-systemic disorders for which mechanistic understanding is limited. To investigate common downstream effects of primary respiratory chain dysfunction on global gene expression and pathway regulation, we reanalyzed transcriptome datasets from all publicly available studies of respiratory dysfunction resulting from genetic disorders, acute pathophysiologic processes, or environmental toxins. A general overview is provided of the bioinformatic processing of transcriptome data to uncover biological insights into in vivo and in vitro adaptations to mitochondrial dy...
Source: The International Journal of Biochemistry and Cell Biology - February 22, 2014 Category: Biochemistry Authors: Zhang Z, Falk MJ Tags: Int J Biochem Cell Biol Source Type: research
[Seminar] Adult obstructive sleep apnoea
Obstructive sleep apnoea is an increasingly common disorder of repeated upper airway collapse during sleep, leading to oxygen desaturation and disrupted sleep. Features include snoring, witnessed apnoeas, and sleepiness. Pathogenesis varies; predisposing factors include small upper airway lumen, unstable respiratory control, low arousal threshold, small lung volume, and dysfunctional upper airway dilator muscles. Risk factors include obesity, male sex, age, menopause, fluid retention, adenotonsillar hypertrophy, and smoking. (Source: LANCET)
Source: LANCET - February 21, 2014 Category: Journals (General) Authors: Amy S Jordan, David G McSharry, Atul Malhotra Tags: Seminar Source Type: research
The relationship between cotinine concentrations and inflammatory markers among highly secondhand smoke exposed non-smoking adolescents.
CONCLUSIONS: Among highly SHS exposed adolescents, cotinine levels had weak inverse association with IL-4 and IL-6, which did not achieve statistical significance. However, our results potentially indicate an immunosuppressive role of SHS. Further research is warranted to explore this hypothesis. PMID: 24548420 [PubMed - in process] (Source: Cytokine)
Source: Cytokine - February 21, 2014 Category: Molecular Biology Authors: Matsunaga Y, Vardavas CI, Plada M, Wärnberg J, Gómez-Martinez S, Tzatzarakis MN, Tsatsakis AM, Díaz EL, Marcos A, Kafatos AG Tags: Cytokine Source Type: research
Cross-country variation in additive effects of socio-economics, health behaviors, and comorbidities on subjective health of patients with diabetes
Conclusion: Countries show different profiles of social and behavioral determinants of subjective health among patients with diabetes. Our study suggests that universal programs that assume that determinants of well-being are similar across different countries may be over-simplistic. Thus instead of universal programs that use one protocol for health promotion of patients in all countries, locally designed interventions should be implemented in each country. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - February 21, 2014 Category: Epidemiology Authors: Shervin Assari Source Type: research
Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activation. [Additions and Corrections]
VOLUME 288 (2013) PAGES 23090–23104 Dr. Chatgilialoglu's last name was misspelled. The correct spelling is shown above. (Source: Journal of Biological Chemistry)
Source: Journal of Biological Chemistry - February 21, 2014 Category: Chemistry Authors: Schlam, D., Bohdanowicz, M., Chatgilialoglu, A., Steinberg, B. E., Ueyama, T., Du, G., Grinstein, S., Fairn, G. D. Tags: Additions and Corrections Source Type: research
Decorin Evokes Mitostatin-dependent Mitophagy [Cell Biology]
Tumor cell mitochondria are key biosynthetic hubs that provide macromolecules for cancer progression and angiogenesis. Soluble decorin protein core, hereafter referred to as decorin, potently attenuated mitochondrial respiratory complexes and mitochondrial DNA (mtDNA) in MDA-MB-231 breast carcinoma cells. We found a rapid and dynamic interplay between peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) and the decorin-induced tumor suppressor gene, mitostatin. This interaction stabilized mitostatin mRNA with concurrent accumulation of mitostatin protein. In contrast, siRNA-mediated abrogation of PGC-1α...
Source: Journal of Biological Chemistry - February 21, 2014 Category: Chemistry Authors: Neill, T., Torres, A., Buraschi, S., Owens, R. T., Hoek, J. B., Baffa, R., Iozzo, R. V. Tags: Glycobiology and Extracellular Matrices Source Type: research
One family cluster of avian influenza A(H7N9) virus infection in Shandong, China
Conclusion: The infection of the index case probably resulted from contact with environmentally contaminated material. For the son, the probable infection source was from the index case during unprotected exposure, but the possibility from the environment or other sources could not be completely ruled out. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 21, 2014 Category: Infectious Diseases Authors: Ti LiuZhenqiang BiXianjun WangZhong LiShujun DingZhenwang BiLiansen WangYaowen PeiShaoxia SongShengyang ZhangJianxing WangDapeng SunBo PangLin SunXiaolin JiangJie LeiQun YuanZengqiang KouBin YangYuelong ShuLei YangXiyan LiKaishun LuJun LiuTao ZhangAiqiang Source Type: research
Year in review 2013: Acute lung injury, interstitial lung diseases, sleep and physiology
Source: Respirology - February 21, 2014 Category: Respiratory Medicine Authors: Amanda Piper, Yuanlin Song, Neil D. Eves, Toby M. Maher Tags: Year in Review Source Type: research
Year in review 2013: Chronic obstructive pulmonary disease, asthma and airway biology
Source: Respirology - February 21, 2014 Category: Respiratory Medicine Authors: Fanny W.S. Ko, Tow K. Lim, Robert J. Hancox, Ian A. Yang Tags: Year in Review Source Type: research
Year in review 2013: Lung cancer, respiratory infections, tuberculosis, cystic fibrosis, pleural diseases, bronchoscopic intervention and imaging
Source: Respirology - February 21, 2014 Category: Respiratory Medicine Authors: Chi Chiu Leung, José M. Porcel, Kazuhisa Takahashi, Marcos I. Restrepo, Pyng Lee, Claire Wainwright Tags: Year in Review Source Type: research
Successful treatment of pulmonary hemangioma with propranolol
Summary Pulmonary hemangioma is a rare benign tumor of the lungs. Airway hemangiomas in particular may lead to feeding difficulties, barking cough, stridor, respiratory distress, and even acute airway obstruction. Hence, such hemangiomas usually require early and aggressive treatment; however, the treatment modalities employed so far have been associated with their own co‐morbidities and potential long‐term adverse effects for the developing child. Here, we report a case of 9‐month‐old girl who presented with dyspnea and diagnosed pulmonary hemangioma in the lower lobe of left lung. Propranolol is now used as a fir...
Source: Pediatric Pulmonology - February 21, 2014 Category: Respiratory Medicine Authors: Nagehan Emiralioğlu, Berna Oğuz, Canan Akyüz, Bilgehan Yalçın, Nural Kiper, Deniz Doğru Ersöz, Ebru Yalçın, Uğur Özçelik Tags: Case Report Source Type: research
Derivation, validation and comparative performance of a simplified chest X‐ray score for assessing the severity and outcome of pulmonary tuberculosis
ConclusionsThe outcome of SPPTB among patients with high prevalence of HIV can acceptably be predicted by simple scores comprising baseline CXR variables, including the Ralph et al. score and the SCS from this study. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - February 21, 2014 Category: Respiratory Medicine Authors: Eric Walter Pefura‐Yone, Christopher Kuaban, Serges Auguste Assamba‐Mpom, Boniface Moifo, André Pascal Kengne Tags: Original Article Source Type: research
Interim estimates of 2013-14 seasonal influenza vaccine effectiveness - United States, february 2014.
This report uses data from 2,319 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness (Flu VE) Network during December 2, 2013-January 23, 2014, to estimate an interim adjusted effectiveness of seasonal influenza vaccine for preventing laboratory-confirmed influenza virus infection associated with medically attended ARI. During this period, overall vaccine effectiveness (VE) (adjusted for study site, age, sex, race/ethnicity, self-rated health, and days from illness onset to enrollment) against influenza A and B virus infection associated with medically attended ARI was 61%. The influenza A (H1N1)pdm09 ...
Source: MMWR Morb Mortal Wkl... - February 21, 2014 Category: Epidemiology Authors: Flannery B, Thaker SN, Clippard J, Monto AS, Ohmit SE, Zimmerman RK, Nowalk MP, Gaglani M, Jackson ML, Jackson LA, Belongia EA, McLean HQ, Berman L, Foust A, Sessions W, Spencer S, Fry AM, Influenza Division, National Center for Immunization and Respirato Tags: MMWR Morb Mortal Wkly Rep Source Type: research
Evolution of primate α and θ defensins revealed by analysis of genomes.
Abstract Defensins are endogenous peptides with cysteine-rich antimicrobial ability that contribute to host defence against bacterial, fungal and viral infections. There are three subfamilies of defensins in primates: α, β and θ-defensins. α-defensins are most present in neutrophils and Paneth cells; β-defensins are involved in protecting the skin and the mucous membranes of the respiratory, genitourinary and gastrointestinal tracts; and θ-defensins are physically distinguished as the only known fully-cyclic peptides of animal origin, which are first isolated from rhesus macaques. All three kinds of defensins...
Source: Molecular Biology Reports - February 21, 2014 Category: Molecular Biology Authors: Li D, Zhang L, Yin H, Xu H, Trask JS, Smith DG, Li Y, Yang M, Zhu Q Tags: Mol Biol Rep Source Type: research
Induction of CYP1A1, CYP1A2, CYP1B1, increased oxidative stress and inflammation in the lung and liver tissues of rats exposed to incense smoke.
Abstract Incense smoke is increasingly being recognized as a potential environmental contaminant and is linked to malignant and non-malignant respiratory diseases. The detoxification of environmental contaminants including polycyclic aromatic hydrocarbons (PAHs) involves the induction of cytochrome P-450 family enzymes (CYPs) by PAHs. However, the detoxification of PAHs also results in the generation of reactive and unstable intermediary metabolites which are implicated in the oxidative stress, DNA damage, and inflammation. It is unclear whether CYPs are similarly induced by incense smoke, which incidentally contai...
Source: Molecular and Cellular Biochemistry - February 21, 2014 Category: Biochemistry Authors: Hussain T, Al-Attas OS, Al-Daghri NM, Mohammed AA, De Rosas E, Ibrahim S, Vinodson B, Ansari MG, El-Din KI Tags: Mol Cell Biochem Source Type: research
Aging Mesenchymal Stem Cells Fail to Protect due to Impaired Migration and Anti-Inflammatory Response.
Abstract Rationale: Aging is characterized by functional impairment and reduced capacity to respond appropriately to environmental stimuli and injury. With age, there is an increase in the incidence and severity of chronic and acute lung diseases. However, the relationship between age and the lung's reduced ability to repair is far from established and necessitates further research in the field. Objectives: Very little is currently known about age-related phenomena in mesenchymal stem cells (MSC). On account of their ability to protect the endothelium and the alveolar epithelium through multiple paracrine mechanism...
Source: American Journal of Respiratory and Critical Care Medicine - February 21, 2014 Category: Respiratory Medicine Authors: Bustos ML, Huleihel L, Kapetanaki MG, Lino-Cardenas CL, Mroz L, Ellis BM, McVerry BJ, Richards TJ, Kaminski N, Cardenes N, Mora AL, Rojas M Tags: Am J Respir Crit Care Med Source Type: research
Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication.
Conclusions. Urinary [TIMP-2]•[IGFBP7] > 0.3 (ng/ml)2/1000 identifies patients at risk for imminent AKI. Funding. Funded by Astute Medical. (ClinicalTrials.gov NCT01573962). PMID: 24559465 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 21, 2014 Category: Respiratory Medicine Authors: Bihorac A, Chawla LS, Shaw AD, Al-Khafaji A, Davison DL, Demuth GE, Fitzgerald R, Ng Gong M, Graham DD, Gunnerson K, Heung M, Jortani S, Kleerup E, Koyner JL, Krell K, Letourneau J, Lissauer M, Miner J, Nguyen HB, Ortega LM, Self WH, Sellman R, Shi J, Str Tags: Am J Respir Crit Care Med Source Type: research
Timing of Tuberculosis Transmission and the Impact of Household Contact Tracing: An Agent-Based Simulation Model.
Conclusions: Household contact tracing is unlikely to transform TB epidemiology in isolation but has the potential - especially with provision of preventive therapy - to augment a comprehensive package of interventions that could substantially reduce the population-level burden of TB. PMID: 24559425 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - February 21, 2014 Category: Respiratory Medicine Authors: Kasaie P, Andrews JR, Kelton WD, Dowdy DW Tags: Am J Respir Crit Care Med Source Type: research
Inappropriate prescribing of combination inhalers in Northern Ireland: retrospective cross-sectional cohort study of prescribing practice in primary care.
CONCLUSIONS: ICS/LABA therapy was initiated in the majority of young subjects with asthma without prior inhaled steroid therapy. Most prescriptions were initiated in the January to March period. However, the prescribing of ICS/LABA did not appear to be driven by asthma symptoms (17% received SABA in the previous 6 months) or severe asthma exacerbation (only 5% received oral steroids). Significant reductions in ICS/LABA, with associated cost savings, would occur if the asthma prescribing guidelines were followed in primary care. PMID: 24570080 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - February 21, 2014 Category: Respiratory Medicine Authors: Sweeney J, Patterson CC, O'Neill S, O'Neill C, Plant G, Lynch V, McAllister T, Heaney LG Tags: Prim Care Respir J Source Type: research