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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Pressure vs controlled mode in laparoscopy cholecystectomy? Still more questions that answers
(Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - May 20, 2015 Category: Respiratory Medicine Authors: Alastair Glossop, Antonio M. Esquinas Tags: Letter to the Editor Source Type: research

A mathematical model approach quantifying patients’ response to changes in mechanical ventilation: Evaluation in pressure support
This paper evaluates how mathematical models of gas-exchange, blood acid–base status, chemical respiratory drive and muscle function can describe the respiratory response of spontaneously breathing patients to different levels of pressure support. (Source: Journal of Critical Care)
Source: Journal of Critical Care - May 20, 2015 Category: Intensive Care Authors: S. Larraza, N. Dey, D.S. Karbing, J.B. Jensen, M. Nygaard, R. Winding, S.E. Rees Source Type: research

[Research Articles] Aminomethyl spectinomycins as therapeutics for drug-resistant respiratory tract and sexually transmitted bacterial infections
The antibiotic spectinomycin is a potent inhibitor of bacterial protein synthesis with a unique mechanism of action and an excellent safety index, but it lacks antibacterial activity against most clinically important pathogens. A series of N-benzyl–substituted 3'-(R)-3'-aminomethyl-3'-hydroxy spectinomycins was developed on the basis of a computational analysis of the aminomethyl spectinomycin binding site and structure-guided synthesis. These compounds had ribosomal inhibition values comparable to spectinomycin but showed increased potency against the common respiratory tract pathogens Streptococcus pneumoniae, Haem...
Source: Science Translational Medicine - May 20, 2015 Category: Biomedical Science Authors: Bruhn, D. F., Waidyarachchi, S. L., Madhura, D. B., Shcherbakov, D., Zheng, Z., Liu, J., Abdelrahman, Y. M., Singh, A. P., Duscha, S., Rathi, C., Lee, R. B., Belland, R. J., Meibohm, B., Rosch, J. W., Bottger, E. C., Lee, R. E. Tags: Research Articles Source Type: research

Human respiratory syncytial virus in children with lower respiratory tract infections or influenza-like illness and its co-infection characteristics with viruses and atypical bacteria in Hangzhou, China
Human respiratory syncytial virus (RSV) is the most important viral agent of acute respiratory infections in infants, young children and immunocompromised and elderly individuals [1,2]. RSV can be rapidly transmitted within childcare institutions [3]. Infection with RSV can result in mild to severe illness, including lower respiratory syndromes such as bronchiolitis and pneumonia. It has been estimated that nearly all two-year-old children have been infected [4]. The attachment G glycoprotein (G protein), a type II glycoprotein, is the most variable region both within and between the major RSV genotypes [5]. (Source: Journ...
Source: Journal of Clinical Virology - May 20, 2015 Category: Virology Authors: Xinfen Yu, Yu Kou, Daozong Xia, Jun Li, Xuhui Yang, Yinyan Zhou, Xiaoyan He Source Type: research

Hypoxia-preconditioned mesenchymal stem cells attenuates bleomycin-induced pulmonary fibrosis
Conclusion: Transplantation of hypoxia-preconditioned MSCs exerted better therapeutic effects in bleomycin-induced pulmonary fibrotic mice and enhanced the survival rate of engrafted MSCs, partially due to the upregulation of hepatocyte growth factor. (Source: Stem Cell Research and Therapy)
Source: Stem Cell Research and Therapy - May 20, 2015 Category: Stem Cells Authors: Ying-Wei LanKong-Bung ChooChuan-Mu ChenTsai-Hsien HungYoung-Bin ChenChung-Hsing HsiehHan-Pin KuoKowit-Yu Chong Source Type: research

A giant molecular proton pump: structure and mechanism of respiratory complex I
Nature Reviews Molecular Cell Biology 16, 375 (2015). doi:10.1038/nrm3997 Author: Leonid A. Sazanov The mitochondrial respiratory chain, also known as the electron transport chain (ETC), is crucial to life, and energy production in the form of ATP is the main mitochondrial function. Three proton-translocating enzymes of the ETC, namely complexes I, III and IV, generate proton motive force, (Source: Nature Reviews Molecular Cell Biology)
Source: Nature Reviews Molecular Cell Biology - May 20, 2015 Category: Cytology Authors: Leonid A. Sazanov Tags: Review Source Type: research

Thiol-based antioxidants elicit mitochondrial oxidation via respiratory complex III.
Abstract Excessive oxidation is widely accepted as a precursor to deleterious cellular function. On the other hand, an awareness of the role of reductive stress as a similar pathological insult is currently emerging. Here, we report early dynamic alterations in compartmentalized glutathione (GSH) redox potentials in response to exogenous thiol-containing antioxidants in live cells. Noninvasive monitoring of intracellular thiol-disulfide exchange via a genetically encoded biosensor targeted to cytosol and mitochondria revealed unexpectedly rapid oxidative shift in the GSH redox potential of the mitochondrial matrix ...
Source: Am J Physiol Cell Ph... - May 20, 2015 Category: Cytology Authors: Kolossov VL, Beaudoin JN, Prabhu Ponnuraj N, DiLiberto SJ, Hanafin WP, Kenis PJ, Gaskins HR Tags: Am J Physiol Cell Physiol Source Type: research

Possible association of rare polymorphism in the ABCB1 gene with rifampin and ethambutol drug-resistant tuberculosis
Human P-glycoprotein (P-gp) is a membrane transporter encoded by ABCB1 (also known as MDR1) that plays a critical role in pharmacokinetics of many unrelated drugs. Rifampin (RMP) and ethambutol (ETB), two anti-tubercular agents, are substrates of P-gp. Single nucleotide polymorphisms (SNPs) in ABCB1 have been associated with resistance to several drugs; however, their association with RMP and ETB resistance in tuberculosis patients has not yet been studied. Genotype/allele frequencies in C1236T, G2677T/A and C3435T SNPs of ABCB1 were obtained from 99 tuberculosis patients susceptible or resistant to RMP and ETB (NoRER or R...
Source: Tuberculosis - May 20, 2015 Category: Respiratory Medicine Authors: José Alberto Rodríguez-Castillo, Alma Y. Arce-Mendoza, Armando Quintanilla-Siller, Adrian Rendon, Mario C. Salinas-Carmona, Adrian G. Rosas-Taraco Tags: Molecular aspects Source Type: research

Preoperative FeNO as a screening indicator of pulmonary complications after abdominal surgery in patients over 60?years old
The incidence of pulmonary complications after abdominal surgery is higher than that of cardiac complications. The perioperative factors currently used to assess the risk of postoperative pulmonary complications (PPCs) are imperfect. FeNO is a marker of respiratory system disease related to the airway inflammatory response and bronchial hyperresponsiveness; it may be a new indicator to screen PPCs. A total of 162 patients over 60?years old scheduled for major abdominal surgery under general anesthesia were chosen to measure their preoperative FeNO level. Statistical analyses including the receiver operating character...
Source: Journal of Breath Research - May 20, 2015 Category: Respiratory Medicine Authors: Xin Pi, Changsong Wang, Yue Li, Juanjuan Zheng, Yinghua Cui, Lei Guo, Ziwei Lin, Xin Zhang and Enyou Li Source Type: research

Evolution of exhaled nitric oxide levels throughout development and aging of healthy humans
It is not fully understood how the fraction of exhaled nitric oxide (FeNO) varies with age and gender in healthy individuals. We aim to describe the evolution of FeNO with age, giving special regard to the effect of gender, and to relate this evolution to natural changes in the respiratory tract. We studied 3081 subjects from NHANES 2007?08 and 2009?10, aged 6?80?years, with no self-reported diagnosis of asthma, chronic bronchitis or emphysema, and with normal values of blood eosinophils and C-reactive protein. The relationship of the mean values of FeNO to age, in all participants and divided by gender, was computed...
Source: Journal of Breath Research - May 20, 2015 Category: Respiratory Medicine Authors: Tiago Jacinto, Andrei Malinovschi, Christer Janson, Jo?o Fonseca and Kjell Alving Source Type: research

ECAR (Endovasculaire ou Chirurgie dans les Anévrysmes aorto-iliaques Rompus): A French Randomized Controlled Trial of Endovascular Versus Open Surgical Repair of Ruptured Aorto-iliac Aneurysms.
CONCLUSION: In this study, EVAR was found to be equal to OSR in terms of 30 day and 1 year mortality. However, EVAR was associated with less severe complications and less consumption of hospital resources than OSR. PMID: 26001320 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - May 20, 2015 Category: Surgery Authors: Desgranges P, Kobeiter H, Katsahian S, Bouffi M, Gouny P, Favre JP, Alsac JM, Sobocinski J, Julia P, Alimi Y, Steinmetz E, Haulon S, Alric P, Canaud L, Castier Y, Jean-Baptiste E, Hassen-Khodja R, Lermusiaux P, Feugier P, Destrieux-Garnier L, Charles-Nels Tags: Eur J Vasc Endovasc Surg Source Type: research

Indirect Toll-like receptor 5-mediated activation of conventional dendritic cells promotes the mucosal adjuvant activity of flagellin in the respiratory tract.
In conclusion, our results demonstrated that indirect TLR5-dependent stimulation of airway conventional dendritic cells is essential to flagellin's mucosal adjuvant activity. PMID: 26003491 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - May 20, 2015 Category: Allergy & Immunology Authors: Fougeron D, Van Maele L, Songhet P, Cayet D, Hot D, Van Rooijen N, Mollenkopf HJ, Hardt WD, Benecke AG, Sirard JC Tags: Vaccine Source Type: research

Absence of Rapid Eye Movements During Sleep in Adult Zebrafish.
Abstract Sleep is not a uniform phenomenon, but is organized in alternating, fundamentally different states, rapid eye movement sleep and non-rapid eye movement sleep. Zebrafish (Danio rerio) have recently emerged as an excellent model for sleep research. Zebrafish are well characterized in terms of development, neurobiology and genetics. Moreover, there are many experimental tools not easily applied in mammalian models that can be readily applied to zebrafish, making them a valuable additional animal model for sleep research. Sleep in zebrafish is defined behaviorally and exhibits the hallmarks of mammalian sleep ...
Source: Behavioural Brain Research - May 20, 2015 Category: Neurology Authors: Árnason BB, Þorsteinsson H, Karlsson KÆ Tags: Behav Brain Res Source Type: research

A 425-Million-Year-Old Silurian Pentastomid Parasitic on Ostracods.
Abstract Pentastomids (tongue worms) are worm-like arthropods known today from ∼140 species [1]. All but four are parasitic on vertebrates. Their life cycle typically involves larval development in an intermediate host followed by maturation in the respiratory tract of a definitive terrestrial host. Fossil pentastomids are exceedingly rare and are known only from isolated juveniles [2-6]. The identity of the possible hosts of fossil pentastomids and the origin of their lifestyle have generated much debate. A new, exceptionally preserved species, described based on adults from 425-million-year-old marine rocks, is...
Source: Current Biology - May 20, 2015 Category: Biology Authors: Siveter DJ, Briggs DE, Siveter DJ, Sutton MD Tags: Curr Biol Source Type: research

Effect of ADRB2 (adrenergic receptor β2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Clinical pathway improves pediatrics asthma management in the emergency department and reduces admissions
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2015 Category: Respiratory Medicine Tags: article Source Type: research

The effect of exercise on exhaled nitric oxide depends on allergic rhinoconjunctivitis in children
Journal of Asthma, Ahead of Print. (Source: Journal of Asthma)
Source: Journal of Asthma - May 19, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Correlation between the severity of apnea and hypopnea sleep, hypertension and serum lipid and glycemic: a case control study
Abstract The purpose of this study was to evaluate the correlation between the severity of obstructive sleep apnea (OSA) and the levels of blood pressure (BP), lipids and glucose, as intermittent hypoxia increases BP, changes the oxidative balance, and can induce the formation of free radicals and atherogenesis. 32 patients were evaluated about BP during wakefulness and sleep, total cholesterol and lipids, LDL (low-density lipoprotein), HDL (high-density lipoprotein), triglycerides, glucose and polysomnography. They were divided into four groups according to the respiratory events per hour of sleep (RDI): control...
Source: European Archives of Oto-Rhino-Laryngology - May 19, 2015 Category: ENT & OMF Source Type: research

TAT-HSP70 Attenuates Experimental Lung Injury
ABSTRACT: Sepsis, a poorly understood syndrome of disordered inflammation, is the leading cause of death in critically ill patients. Lung injury, in the form of acute respiratory distress syndrome (ARDS), is the most common form of organ injury in sepsis. The heat shock response, during which heat shock proteins (HSPs) are expressed, is an endogenous mechanism to protect cells from injury. We have found that the abundance of pulmonary HSP70 is not increased after cecal ligation and double puncture (CLP) in a rat model of sepsis-induced ARDS. Using the HIV-1 trans-activator of transcription (TAT) cell–penetrating protein,...
Source: Shock - May 19, 2015 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Correction: The Acute Respiratory Distress Syndrome: From Mechanism to Translation.
PMID: 25980032 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - May 19, 2015 Category: Allergy & Immunology Authors: Han S, Mallampalli RK Tags: J Immunol Source Type: research

Analysis of Forced Expiratory Flow Signals Using the New Luus–Jaakola Optimization Procedure
Conclusion: The method can be used to estimate FVC by analyzing an incomplete FEFT curve, providing the length of the curve is more than 3 s. Significance: This me- hod can help the subjects who cannot complete the forced expiratory maneuver to provide a reliable estimate of FVC and also can be used to analyze the unacceptable spirometry because of early termination of exhalation. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - May 19, 2015 Category: Biomedical Engineering Source Type: research

“It’s safer to ...” Parent consulting and clinician antibiotic prescribing decisions for children with respiratory tract infections: an analysis across four qualitative studies
Publication date: Available online 16 May 2015 Source:Social Science & Medicine Author(s): Christie Cabral , Patricia J. Lucas , Jenny Ingram , Alastair D. Hay , Jeremy Horwood This paper reports a cross-study analysis of four studies, aiming to understand the drivers of parental consulting and clinician prescribing behaviour when children under 12 years consult primary care with acute respiratory tract infections (RTI). Qualitative data were obtained from three primary studies and one systematic review. Purposeful samples were obtained for (i) a focus group study of parents’ information needs and help seeking;...
Source: Social Science and Medicine - May 19, 2015 Category: Psychiatry & Psychology Source Type: research

Limiting volume with modern ventilators
Conclusions: Modern ventilators have an increasing number of optional settings. These settings may increase the delivered tidal volume and disrupt a low tidal-volume strategy. Recognizing how each setting within a mode affects the type of breath delivered is critical when caring for ventilator-dependent patients. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Wing, T. J., Haan, L., Ashworth, L. J., Anderson, J. Tags: Original Research Source Type: research

Long-acting muscarinic antagonists for the prevention of exacerbations of chronic obstructive pulmonary disease
Exacerbations of chronic obstructive pulmonary disease (COPD) have important consequences for lung function, health status and mortality. Furthermore, they are associated with high economic costs, predominantly related to hospitalization. They are managed acutely with short-acting bronchodilators, systemic corticosteroids or antibiotics; however, a large proportion of COPD exacerbations are unreported and therefore untreated or self-managed. There is evidence to suggest that these unreported exacerbations also have important consequences for health status; therefore, reducing exacerbation risk is an important goal in the m...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Jones, P. W. Tags: Reviews Source Type: research

The efficacy of crizotinib in patients with ALK-positive nonsmall cell lung cancer
Molecular profiling of nonsmall cell lung cancer (NSCLC) contributes to better understanding the different molecular subtypes of this heterogeneous group of diseases. The discovery of oncogenic ALK rearrangements in NSCLC and the subsequent success in their therapeutic targeting with crizotinib reinforces the benefits of a precision approach to systemic anticancer therapy. In addition, the rapid development of crizotinib from first discovery thorough accelerated US Food and Drug Administration approval, and late stage confirmatory clinical trials, exemplifies the success of the drug development strategy of close collaborat...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Pender, A., Popat, S. Tags: Reviews Source Type: research

Targeting the immune system to treat lung cancer: rationale and clinical experience
The use of immunotherapy that harnesses and enhances the innate powers of the immune system to fight cancer cells represents the most promising new cancer treatment approach since the development of the first chemotherapies and, more recently, targeted therapies. Unexpectedly, lung cancer has recently emerged as an exciting new target for immune-based therapies. Several approaches to immunotherapy for lung cancer have shown promise in early clinical trials and in late-phase development. The most advanced strategies can be split into two main categories: therapeutic vaccines and checkpoint inhibitors. At this time of great ...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Guibert, N., Delaunay, M., Mazieres, J. Tags: Reviews Source Type: research

Nintedanib in the treatment of idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal lung disease that occurs in older adults. The clinical course of IPF is variable and hard to predict in an individual patient. Nintedanib is a tyrosine kinase inhibitor that has recently been approved in the US and European Union for the treatment of IPF. Preclinical studies have shown that nintedanib interferes with processes active in fibrosis such as fibroblast proliferation, migration and differentiation and the secretion of extracellular matrix. The safety and efficacy of nintedanib have been investigated in the phase II TOMORROW trial and in tw...
Source: Therapeutic Advances in Respiratory Disease - May 19, 2015 Category: Respiratory Medicine Authors: Mazzei, M. E., Richeldi, L., Collard, H. R. Tags: Reviews Source Type: research

Interstitial lung disease preceding primary biliary cirrhosis in a male patient
Publication date: Available online 18 May 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): I. Franco , A. Dubini , S. Piciucchi , G. Casoni , V. Poletti A 47-year-old male was admitted with subacute onset of dry cough and fever. Chest tomography demonstrated multifocal areas of consolidation and ground glass attenuation. Cytological analysis of bronchoalveolar lavage revealed lymphocytosis and eosinophilia and anatomopathological exam of transbronchial cryobiopsy showed poorly formed non-caseous granulomas associated to interstitial lympho-plasmocitary infiltrate. The diagnosis of idiopathic gra...
Source: Revista Portuguesa de Pneumologia - May 19, 2015 Category: Respiratory Medicine Source Type: research

High-Throughput Hit Screening Cascade to Identify Respiratory Syncytial Virus (RSV) Inhibitors
Respiratory syncytial virus (RSV) infects 99% of children by age 2 years and is a leading cause of serious lower respiratory tract infection (LRTI) and infant hospitalization in the United Kingdom. Identification of efficacious RSV therapeutics has been hindered by the lack of a robust and appropriate primary assay for high-throughput screening (HTS). Here we report an HTS cascade that identified inhibitors of RSV replication using a robust RSV replicon luminescence-reporter assay for the primary campaign. The performance of the assay was consistent and reliable at scale, with Z' of 0.55 ± 0.08 across 150 assay plat...
Source: Journal of Biomolecular Screening - May 19, 2015 Category: Molecular Biology Authors: Plant, H., Stacey, C., Tiong-Yip, C.-L., Walsh, J., Yu, Q., Rich, K. Tags: Original Research Source Type: research

Delaying the widespread emergence of cephalosporin-resistant gonorrhoea: what is the best target?
Neisseria gonorrhoeae is associated with high morbidity worldwide. The emergence of cephalosporin and macrolide resistance represents a grave threat to the control of a disease, which, if untreated, can lead to serious reproductive complications in women, blindness in neonates, facilitated spread of HIV and, in rare cases, life-threatening disseminated infections.1 2 A plenary was convened at the Centers for Disease Control and Prevention's (CDC) sexually transmitted disease (STD) Prevention Conference held in Atlanta, Georgia, 9–12 June 2014, to discuss several key aspects pertaining to this issue. The Scientific Co...
Source: Sexually Transmitted Infections - May 19, 2015 Category: Sexual Medicine Authors: Tuddenham, S., Ghanem, K. G. Tags: Epidemiologic studies, Drugs: infectious diseases, HIV/AIDS, Ophthalmology, Child health, Inflammation, Respiratory medicine, HIV / AIDS, Gonorrhoea, HIV infections Antimicrobial resistance futures for gonorrhoea Source Type: research

Will targeting oropharyngeal gonorrhoea delay the further emergence of drug-resistant Neisseria gonorrhoeae strains?
Gonorrhoea is an important sexually transmitted infection associated with serious complications and enhanced HIV transmission. Oropharyngeal infections are often asymptomatic and will only be detected by screening. Gonococcal culture has low sensitivity (<50%) for detecting oropharyngeal gonorrhoea, and, although not yet approved commercially, nucleic acid amplification tests (NAAT) are the assay of choice. Screening for oropharyngeal gonorrhoea should be performed in high-risk populations, such as men-who-have-sex-with-men(MSM). NAATs have a poor positive predictive value when used in low-prevalence populations. Gonoco...
Source: Sexually Transmitted Infections - May 19, 2015 Category: Sexual Medicine Authors: Lewis, D. A. Tags: Drugs: infectious diseases, HIV/AIDS, Respiratory medicine, HIV / AIDS, Gonorrhoea, HIV infections, Screening (epidemiology), Screening (public health) Antimicrobial resistance futures for gonorrhoea Source Type: research

Lung ultrasonography: an effective way to diagnose community-acquired pneumonia
Conclusions Lung ultrasonography has a better diagnostic sensitivity and accuracy for diagnosing CAP compared with CXR. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - May 19, 2015 Category: Emergency Medicine Authors: Liu, X.-l., Lian, R., Tao, Y.-k., Gu, C.-d., Zhang, G.-q. Tags: Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics) Original article Source Type: research

Assessment of the feasibility of an ultra-low power, wireless digital patch for the continuous ambulatory monitoring of vital signs
Conclusions Overall agreement between digital patch and clinical monitor was satisfactory, as was the efficacy of the system for automatic rejection of invalid data. Wireless monitoring technologies, such as the one tested, may offer clinical value when implemented as part of wider hospital systems that integrate and support existing clinical protocols and workflows. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Hernandez-Silveira, M., Ahmed, K., Ang, S.-S., Zandari, F., Mehta, T., Weir, R., Burdett, A., Toumazou, C., Brett, S. J. Tags: Open access, Medical management, Patient-centred medicine Research Source Type: research

Longitudinal impact of demographic and clinical variables on health-related quality of life in cystic fibrosis
Conclusions Demographic and changes in clinical variables were independently associated with a change in HRQoL over time. Compared with these longitudinal data, cross-sectional data are inadequate when evaluating the relationships between HRQoL domains and key demographic and clinical variables, as they fail to recognise the full impact of the CF disease trajectory and its treatments on quality of life. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Abbott, J., Morton, A. M., Hurley, M. A., Conway, S. P. Tags: Open access, Mental health, Respiratory medicine Research Source Type: research

Work-related allergies to storage mites in Parma (Italy) ham workers
Conclusions Ham processing workers, as well as workers involved in any meat processing work that includes curing, should be informed about the occupational risk of sensitisation to mites. (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Tafuro, F., Ridolo, E., Goldoni, M., Montagni, M., Mutti, A., Corradi, M. Tags: Open access, Occupational and environmental medicine, Respiratory medicine Research Source Type: research

The diagnostic accuracy of chest ultrasound for CT-detected radiographic consolidation in hospitalised adults with acute respiratory failure: a systematic review
Conclusions Four small studies suggest ultrasound is highly sensitive and specific for consolidation in ARF, but high risk of bias and concerns about applicability in all studies may have inflated diagnostic accuracy. Further robustly designed studies are needed to define the role of ultrasound in this setting. Trial registration number (CRD42013006472). (Source: BMJ Open)
Source: BMJ Open - May 19, 2015 Category: Journals (General) Authors: Hew, M., Corcoran, J. P., Harriss, E. K., Rahman, N. M., Mallett, S. Tags: Open access, Evidence based practice, Intensive care, Radiology and imaging, Research methods, Respiratory medicine Source Type: research

subsp in prevention of common infections in healthy children attending day care centers – randomized, double blind, placebo-controlled study
The aim of our study was to investigate the role of Bifidobacterium animalis subsp. lactis (BB-12®) in the prevention of common (gastrointestinal and respiratory) infections in healthy children who attend day care centers. (Source: Clinical Nutrition)
Source: Clinical Nutrition - May 19, 2015 Category: Nutrition Authors: Iva Hojsak, Ana Močić Pavić, Tea Kos, Jelena Dumančić, Sanja Kolaček Tags: Randomized Control Trials Source Type: research

Regulation of cell death by intracellular delivery of nitric oxide to macrophages infected with virulent or avirulent
Macrophages do not readily undergo spontaneous apoptosis, but infection with Mycobacterium tuberculosis (Mtb) may induce cell death in different ways (Divangahi, Behar, & Remold, 2013). Nitric oxide (NO) mediates several innate defence mechanisms against intracellular Mtb, including apoptosis (Chan, Chan, & Schluger, 2001), and is also intrinsically bactericidal (Verma et al., 2013). NO mediates effects of adaptive immunity as indicated by the observation that the inducible nitric oxide synthase gene is strongly induced in macrophages by gamma interferon. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: Rahul Kumar Verma, Amit Misra Source Type: research

Density equalizing mapping of the global tuberculosis research architecture
Tuberculosis belongs to the lung infectious diseases with the highest impact on global burden of disease. Yet there is no concise scientometric study about tuberculosis research. Therefore, the NewQiS project elected this subject as focus of an in depth analysis to perform density equalizing mapping in combination with scientometrics. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: David A. Groneberg, Esther Weber, Alexander Gerber, Axel Fischer, Doris Klingelhoefer, Doerthe Brueggmann Source Type: research

Liposomal delivery of Lipoarabinomannan triggers specific T-cells
Lipoarabinomannan (LAM) is a major cell wall component of Mycobacterium tuberculosis (Mtb). LAM specific human T-lymphocytes release interferon-γ (IFNγ) and have antimicrobial activity against intracellular Mtb suggesting that they contribute to protection. Therefore the induction of LAM-specific memory T-cells is an attractive approach for the design of a new vaccine against tuberculosis. A prerequisite for the activation of LAM-specific T-cells is the efficient uptake and transport of the glycolipid antigen to the CD1 antigen presenting machinery. (Source: Tuberculosis)
Source: Tuberculosis - May 19, 2015 Category: Respiratory Medicine Authors: Stephanie Kallert, Sebastian Zenk, Paul Walther, Mark Grieshober, Tanja Weil, Steffen Stenger Tags: Immunological Aspects Source Type: research

The Hispanic health paradox across generations: the relationship of child generational status and citizenship with health outcomes
This study examines immigrant respiratory health disparities among Hispanic children in terms of current asthma, bronchitis, and allergies using an expanded six-group immigrant cohort framework that includes citizenship and the fourth-plus generation. (Source: Public Health)
Source: Public Health - May 19, 2015 Category: Global & Universal Authors: A.J. Balcazar, S.E. Grineski, T.W. Collins Tags: Original Research Source Type: research

SNO-Hb and hypoxic vasodilation [Medical Sciences]
The respiratory system has traditionally been thought of as a two-gas model: hemoglobin (Hb) within red blood cells (RBC) binds oxygen in the lungs, delivers the oxygen to peripheral tissues, and binds carbon dioxide, which is returned to the lungs, released, and expired. However, fine-tuning of the system is required... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - May 19, 2015 Category: Science Authors: Kulandavelu, S., Balkan, W., Hare, J. M. Tags: Commentaries Source Type: research

Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration.
CONCLUSIONS: Obstructive sleep apnea and adverse respiratory events in the recovery room are harbingers of increased risk for respiratory depression or sedation requiring naloxone after discharge from anesthesia care. Also, patients administered naloxone received more opioids and other sedating medications after discharge from anesthetic care. Our findings suggest that these patients may benefit from more careful monitoring after being discharged from anesthesia care. PMID: 25993390 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - May 19, 2015 Category: Anesthesiology Authors: Weingarten TN, Herasevich V, McGlinch MC, Beatty NC, Christensen ED, Hannifan SK, Koenig AE, Klanke J, Zhu X, Gali B, Schroeder DR, Sprung J Tags: Anesth Analg Source Type: research

Preoperative Aspirin Use and Lung Injury After Aortic Valve Replacement Surgery: A Retrospective Cohort Study.
CONCLUSIONS: Within the constraints of this analysis that included only 22 affected patients, preoperative aspirin use was not associated with a decreased incidence of ARDS after aortic valve replacement surgery or improved oxygenation. PMID: 25993389 [PubMed - as supplied by publisher] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - May 19, 2015 Category: Anesthesiology Authors: Mazzeffi M, Kassa W, Gammie J, Tanaka K, Roman P, Zhan M, Griffith B, Rock P Tags: Anesth Analg Source Type: research