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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Are nocturnal hypoxemia and hypercapnia associated with desaturation immediately after adenotonsillectomy?
ConclusionPatients <3 years of age are most likely to have postoperative hypoxemia after adenotonsillectomy. Gas exchange abnormalities did not correlate with postoperative desaturations, although age and peak EtCO2 did strongly correlate. (Source: Pediatric Anesthesia)
Source: Pediatric Anesthesia - April 10, 2015 Category: Anesthesiology Authors: Nicholas M. Dalesio, Douglas H. McMichael, James R. Benke, Sean Owens, Kathryn A. Carson, Deborah A. Schwengel, Alan R. Schwartz, Stacey L. Ishman Tags: Original Article Source Type: research

Local Allergic Nasal Reactions Convert to Classic Systemic Allergic Reactions: A Long-Term Follow-Up
Conclusion: Conversions from local to classic systemic respiratory allergic reactions appear to be a common phenomenon.Int Arch Allergy Immunol 2015;166:154-160 (Source: International Archives of Allergy and Immunology)
Source: International Archives of Allergy and Immunology - April 10, 2015 Category: Allergy & Immunology Source Type: research

Predicting risk of COPD in primary care: development and validation of a clinical risk score.
CONCLUSIONS: Risk factors associated with COPD and routinely recorded in primary care have been used to develop and externally validate a new COPD risk score. This could be used to target patients for case finding. PMID: 25852945 [PubMed] (Source: Respiratory Care)
Source: Respiratory Care - April 10, 2015 Category: Respiratory Medicine Authors: Haroon S, Adab P, Riley RD, Marshall T, Lancashire R, Jordan RE Tags: BMJ Open Respir Res Source Type: research

Recurrent lung atelectasis from fibrin plugs as a very early complication of bronchial thermoplasty: a case report.
CONCLUSION: The originality of our case report is related to the recurrence of bronchial plugging with lobar atelectasis within one and five hours respectively, after two sequential BT procedures. At the histological evaluation the bronchial plugs appeared very different from the typical mucoid asthma plugs, being composed prevalently by fibrin. It can be hypothesized that intense thermal stimulation of the bronchial mucosa may represent a strong boost for inflammation in susceptible patients, with microvascular alteration induced directly by heat or through the release of mediators. Although in severe asthma a risk of ate...
Source: Respiratory Care - April 10, 2015 Category: Respiratory Medicine Authors: Facciolongo N, Menzella F, Lusuardi M, Piro R, Galeone C, Castagnetti C, Cavazza A, Carbonelli C, Zucchi L, Salsi PP Tags: Multidiscip Respir Med Source Type: research

Respiratory Effects of Adaptive Servoventilation Therapy in Patients with Heart Failure and Cheyne-Stokes Respiration Compared to Healthy Volunteers
Conclusions: ASV therapy might result in hyperventilation when subjects are awake, but while asleep, PtcCO2 increased to mid-normal values, effects that would be favorable in HF patients with CSR.Respiration (Source: Respiration)
Source: Respiration - April 10, 2015 Category: Respiratory Medicine Source Type: research

Creating a Sustainable, Interprofessional-Team Training Program: Initial Results
Conclusion: A single resuscitation simulation was not enough interventional dosage for staff to improve the resuscitation process. A longitudinal study should be conducted to determine the effectiveness of the program after staff members have repeated the program multiple times. Implications: A unit-based quality-improvement simulation training program could help improve the first-5-minute response and resuscitation skills of staff by increasing the frequency of unit-based training overseen by the unit’s clinical nurse specialist. (Source: Clinical Nurse Specialist)
Source: Clinical Nurse Specialist - April 10, 2015 Category: Nursing Tags: Feature Article Source Type: research

Current management of acute liver failure
Purpose of review: Acute liver failure (ALF) is a rare but life-threatening systemic disorder. Survival rates with or without emergency liver transplantation (ELT) are increasing. The benefit of ELT in some cases has been questioned and the potential for survival with medical management alone is changing our approach to the management of this disease. Recent findings: Survival rates for all causes of ALF are increasing because of improvements in the care of the critically ill patient. A multifactorial approach involving support of respiratory, circulatory and renal function together with measures to avoid intracranial hype...
Source: Current Opinion in Gastroenterology - April 10, 2015 Category: Gastroenterology Tags: LIVER: Edited by Don C. Rockey Source Type: research

Relationship Between Model for End-Stage Liver Disease Score and 30-Day Outcomes For Patients Undergoing Elective Colorectal Resections: An American College of Surgeons-National Surgical Quality Improvement Program Study
CONCLUSIONS: Consistent with previous reports, patients with higher Model of End-Stage Liver Disease scores have a significantly higher risk of death and major morbidity in the 30 days after elective colorectal resection (see Video, Supplemental Digital Content, ). (Source: Diseases of the Colon and Rectum)
Source: Diseases of the Colon and Rectum - April 10, 2015 Category: Gastroenterology Tags: Original Contributions: Benign Colorectal Disease Source Type: research

Risk factors associated with lower defecation frequency in hospitalized older adults: a case control study
Conclusions: Approximately 38% of hospitalized older adults had lower DF. AECOPD and use of muscle relaxant were significantly associated with lower DF; while supplementation of potassium and antibiotic use were protective for lower DF risk after adjusting for other variables. (Source: BMC Geriatrics)
Source: BMC Geriatrics - April 10, 2015 Category: Geriatrics Authors: Jen-Tzer GauUtkarsh AcharyaM KhanTzu-Cheg Kao Source Type: research

Sensitization to workplace respiratory allergens among bakery workers in Douala, Cameroon: a cross-sectional study
Conclusion: Bakers in Douala are at risk of sensitization to occupational allergens. The environmental hygiene in bakeries, health surveillance and the use of personal protective equipment could reduce the risk of respiratory allergies among bakers. (Source: BioMed Central)
Source: BioMed Central - April 10, 2015 Category: Journals (General) Authors: Bertrand Mbatchou NgahaneFrancis NdeEliane NgomoEmmanuel Afane Ze Source Type: research

Classic Kaposi Sarcoma: to treat or not to treat?
Conclusion: Given the possible indolent behaviour of KS, we believe that close surveillance can represent a valuable approach in selected cases. (Source: BioMed Central)
Source: BioMed Central - April 10, 2015 Category: Journals (General) Authors: Bruno VincenziLoretta D’OnofrioAnna FrezzaRosario GrassoValentina FaustiDaniele SantiniAngelo Dei TosGiuseppe Tonini Source Type: research

Understanding the lung allocation score for the non-transplant pulmonologist
Abstract In order to better allocate scarce donor lung organs, the lung allocation score (LAS) was implemented in May 2005. The goals of the LAS were to reduce waiting list mortality of lung transplant candidates, to prioritize candidates based on medical urgency, and to maximize overall lung transplant benefit. Pre-transplant candidate variables are used to calculate waiting list survival, post-transplant survival, and transplant benefit measures. These measures produce a numerical lung allocation score between 0 and 100 with a higher score recipient receiving a greater priority ranking for donor lungs. LAS imple...
Source: Current Respiratory Care Reports - April 10, 2015 Category: Respiratory Medicine Source Type: research

Change in serum marker of oxidative stress in the progression of idiopathic pulmonary fibrosis
Conclusions Serum oxidative stress values increased with disease progression in IPF patients. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2015 Category: Respiratory Medicine Source Type: research

Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
In this study, BI 671800 (50, 200 or 400 mg) and fluticasone propionate (220 μg) all given twice daily (bid) were compared with bid placebo in symptomatic controller-naïve adults with asthma (Trial 1), and BI 671800 400 mg bid compared with montelukast 10 mg once daily (qd), and matching placebo bid, in patients with asthma receiving inhaled fluticasone (88 μg bid) (Trial 2). The primary endpoint in both trials was change from baseline in trough forced expiratory volume in 1 second (FEV1) percent predicted. After 6 weeks’ treatment, adjusted mean treatment differences (SE) for the primary endpoint compared with placeb...
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2015 Category: Respiratory Medicine Source Type: research

Nintedanib modulates surfactant protein-D expression in A549 human lung epithelial cells via the c-Jun N-terminal kinase-activator protein-1 pathway
In this study, we investigated whether nintedanib modulates SP-D expression in human lung epithelial (A549) cells using quantitative real-time reverse transcriptase polymerase chain reaction and western blotting. To investigate the mechanisms underlying the effects of nintedanib, we evaluated the phosphorylation of c-Jun N-terminal kinase (JNK) and its downstream target c-Jun. The effect of the JNK inhibitor SP600125 on c-Jun phosphorylation was also tested. Activation of activator protein-1 (AP-1) was examined using an enzyme-linked immunosorbent assay-based test, and cell proliferation assays were performed to estimate t...
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2015 Category: Respiratory Medicine Source Type: research

Therapeutic efficacy of liposomes containing 4-(5-pentadecyl-1,3,4-oxadiazol-2-yl)pyridine in a murine model of progressive pulmonary tuberculosis
Conclusion These results confirm and extend the reported highly efficient anti-mycobacterial activity of this lipophilic oxidazole derivative when it is carried by liposomes in mice suffering from late progressive pulmonary TB induced by drug-sensitive, and most prominently by, MDR strains. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2015 Category: Respiratory Medicine Source Type: research

Efficacy and safety of phosphodiesterase type-5 inhibitors for pulmonary arterial hypertension: A meta-analysis focusing on 6MWD
Conclusions The results of present meta-analysis suggest that treatment with PDE-5 inhibitors improves the 6MWD, clinical symptoms, hemodynamic parameters, and a tendency of survival benefits. In patients treated with PDE-5 inhibitor monotherapy, the 6MWD significantly increased when compared to combination therapies. (Source: Pulmonary Pharmacology and Therapeutics)
Source: Pulmonary Pharmacology and Therapeutics - April 10, 2015 Category: Respiratory Medicine Source Type: research

Co-infection of long-standing extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) and non-tuberculosis mycobacteria: A case report
We report a 69-years-old Iranian HIV negative male patient, with long-standing pulmonary tuberculosis (eleven years) co-infected with non-tuberculosis mycobacteria. Despite of initiation of first line anti-tuberculosis therapy after diagnosis the patient poorly respond because of low compliance with anti-TB treatment. After several incomplete treatments the smear was still positive and thus drug susceptibility tests were performed on isolated organism which revealed that the organisms was resistant not only against isoniazid and rifampin but also against Ofloxacin (OFX), Capreomycin (CAP), p-aminosalicylic acid (PAS), ethi...
Source: Respiratory Medicine Case Reports - April 10, 2015 Category: Respiratory Medicine Source Type: research

Endobronchial electrocautery wire snare prior to wedge bronchoplastic lobectomy for central-type lung cancer: A case report
Conclusion The combination of a bronchoscopic electrocautery wire snare and bronchoplastic surgical procedure was useful for the treatment of central-type lung cancer such as in our case. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 10, 2015 Category: Surgery Source Type: research

Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome
Abstract Barth syndrome (BTHS) is an X-linked metabolic disorder that causes cardiomyopathy in infancy and is linked to mutations within the Tafazzin (TAZ) gene. The first mouse model, a TAZ knockdown model (TAZKD), has been generated to further understand the bioenergetics leading to cardiomyopathy. However, the TAZKD model does not show early signs of cardiomyopathy, and cardiac pathophysiology has not been documented until 7–8 months of age. Here we sought to determine the impact of endurance training on the cardiac and skeletal muscle phenotype in young TAZKD mice. TAZKD exercise trained (TAZKD-ET) and cont...
Source: Journal of Inherited Metabolic Disease - April 10, 2015 Category: Internal Medicine Source Type: research

Making sense of nickel accumulation and sub-lethal toxic effects in saline waters: fate and effects of nickel in the green crab, Carcinus maenas
This study investigated Ni accumulation and physiological mechanisms of sub-lethal Ni toxicity in the euryhaline green crab Carcinus maenas. Male crabs were exposed to 8.2μg/L (the US EPA chronic criterion concentration for salt waters) of waterborne Ni (radiolabelled with 63Ni) at three different salinities, 20%, 60% and 100% SW for 24hours. Whole body Ni accumulation in 20% SW was 3-5 fold greater than in 60% or 100% SW, and &gt; 80% of accumulated Ni was in the carapace at all salinities. Ni also accumulated in posterior gill 8, which showed a higher accumulation in 20% SW than in other salinities, a pattern also s...
Source: Aquatic Toxicology - April 10, 2015 Category: Toxicology Source Type: research

Poor performance characteristics of conventional PCR in detection of respiratory syncytial virus-experience of a tertiary care centre in Southern India
G Nandhini, S Sujatha, N Jain, R Dhodapkar, T Kadhiravan, S KrishnamurthyIndian Journal of Medical Microbiology 2015 33(2):274-276Respiratory syncytial virus (RSV) is a significant cause of contagious acute respiratory infections in children and older adults. Since there are contradictory reports regarding the efficacy of different methods to detect RSV, we evaluated the performance of the conventional PCR versus real-time PCR in 222 patients with acute respiratory infections (ARI) recruited between January 2012 and March 2013. Conventional PCR had a very poor sensitivity of 40% (95% CI: 19.2-63.9%) an...
Source: Indian Journal of Medical Microbiology - April 10, 2015 Category: Microbiology Authors: G NandhiniS SujathaN JainR DhodapkarT KadhiravanS Krishnamurthy Source Type: research

Laryngoplasty in Standing Horses
ConclusionsLaryngoplasty performed with the horse standing avoids risks associated with general anesthesia and recovery and yields comparable results in nonracing horses, to laryngoplasty performed with the horse anesthetized. This technique reduces cost and allows accurate intraoperative adjustment of the degree of arytenoid abduction. (Source: Veterinary Surgery)
Source: Veterinary Surgery - April 10, 2015 Category: Veterinary Research Authors: Fabrice Rossignol, Amélie Vitte, Josef Boening, Michael Maher, Antoine Lechartier, Olivier Brandenberger, Manuel Martin‐Flores, Hayley Lang, Wade Walker, Norm G. Ducharme Tags: Original Article‐Clinical Source Type: research

Critical role of eukaryotic elongation factor 1 alpha 1 (EEF1A1) in avian reovirus sigma-C-induced apoptosis and inhibition of viral growth
We report here the identification of eukaryotic elongation factor 1 alpha 1 (EEF1A1) as the interacting partner of σC. We found that σC-induced apoptosis in DF-1 cells could be completely abolished by knockdown of EEF1A1 by siRNA. Furthermore, knockdown of EEF1A1 markedly reduced ARV-induced apoptosis associated with decreased caspase-9 and -3 activation and cytochrome C release, leading to increased ARV growth in host cells. Thus, EEF1A1 plays a critical role in σC-induced apoptosis and inhibition of viral growth. (Source: Archives of Virology)
Source: Archives of Virology - April 10, 2015 Category: Virology Source Type: research

Safety and Efficacy Study of the Cyclooxygenase‐2 Inhibitor Parecoxib Sodium Applied for Postoperative Analgesia After Endo‐Nasal Operation
ConclusionsParecoxib sodium was effective and safe when used for postoperative analgesia in endo‐nasal operation. (Source: Pain Practice)
Source: Pain Practice - April 10, 2015 Category: Anesthesiology Authors: Hong Chen, Ailin Luo Tags: Original Article Source Type: research

Complications of Stevens–Johnson syndrome beyond the eye and skin
Discussion SJS/TEN is a multi-organ disease requiring multidisciplinary care from a variety of specialists. Affected patients have complex hospital stays, and their quality of life may be severely impacted by multiple long-term complications. We believe that preventative care in the acute setting might limit the development and progression of many of the sequelae described above. (Source: Burns)
Source: Burns - April 10, 2015 Category: Dermatology Source Type: research

Sustained decrease in laboratory detection of rotavirus after implementation of routine vaccination - United States, 2000-2014.
Abstract Rotavirus infection is the leading cause of severe gastroenteritis among infants and young children worldwide. Before the introduction of rotavirus vaccine in the United States in 2006, rotavirus infection caused significant morbidity among U.S. children, with an estimated 55,000-70,000 hospitalizations and 410,000 clinic visits annually. The disease showed a characteristic winter-spring seasonality and geographic pattern, with annual seasonal activity beginning in the West during December-January, extending across the country, and ending in the Northeast during April-May. To characterize changes in rotavi...
Source: MMWR Morb Mortal Wkl... - April 10, 2015 Category: Epidemiology Authors: Aliabadi N, Tate JE, Haynes AK, Parashar UD Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Cough and the Transmission of Tuberculosis
Cough is a predominant feature of respiratory infection and, in tuberculosis, is of prime importance for transmitting infection. Tuberculosis is transmitted by the air, yet the process by which bacilli are aerosolized has received little attention. Features of cough may account for differences in transmission rates from source cases of pulmonary disease. We review the literature on the mechanisms and characteristics of cough in tuberculosis in the context of the dissemination of infection. Coughing is probably more important than other respiratory maneuvers, and characteristics of mucus may have an important role but data ...
Source: The Journal of Infectious Diseases - April 10, 2015 Category: Infectious Diseases Authors: Turner, R. D., Bothamley, G. H. Tags: REVIEW Source Type: research

Seasonality of Both Bacteremic and Nonbacteremic Pneumonia Coincides With Viral Lower Respiratory Tract Infections in Early Childhood, in Contrast to Nonpneumonia Invasive Pneumococcal Disease, in the Pre-Pneumococcal Conjugate Vaccine Era
We assessed the seasonality of viral lower respiratory tract infections (V-LRI), bacteremic pneumonia, nonbacteremic pneumonia and nonpneumonia invasive pneumococcal diseases (IPD) in the pre-PCV era. Both bacteremic and nonbacteremic pneumonia seasonality peaked in winter, coinciding with V-LRI seasonality, whereas non-pneumonia IPD peaked in autumn before V-LRI increase, suggesting different pathogenesis. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - April 10, 2015 Category: Infectious Diseases Authors: Ben-Shimol, S., Greenberg, D., Hazan, G., Shemer-Avni, Y., Givon-Lavi, N., Dagan, R. Tags: BRIEF REPORT Source Type: research

Persons injured during acute chemical incidents - hazardous substances emergency events surveillance, nine States, 1999-2008.
This report summarizes the data collected on injured persons from the nine states (Colorado, Iowa, Minnesota, New York, North Carolina, Oregon, Texas, Washington, and Wisconsin) that participated in HSEES during its last 10 full years of data collection (1999-2008). RESULTS: A total of 57,975 chemical incidents were reported by these states during the 10-year surveillance period. In 4,621 (8%) of these incidents, 15,506 persons were injured. Among them, 354 deaths occurred. The most commonly reported category of injured persons included employees of the responsible party (7,616 [49%]), members of the general public (4,...
Source: MMWR Surveill Summ - April 10, 2015 Category: Epidemiology Authors: Duncan MA, Wu J, Neu MC, Orr MF Tags: MMWR Surveill Summ Source Type: research

Diagnostic utility of polysomnography in children less than 2 years of age?
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 10, 2015 Category: Respiratory Medicine Authors: Ian MacLusky Tags: Editorial Source Type: research

Imaging of the Central Airways with Bronchoscopic Correlation
A wide variety of pathologic processes, both benign and malignant, affect the central airways. These processes may be classified into 4 distinct groups: anatomic variants, lesions that result in focal or diffuse airway narrowing, and those that result in multinodular airway disorder. Key to the accurate assessment of the central airways is meticulous imaging technique, especially the routine acquisition of contiguous high-resolution, 1-mm to 1.5-mm images. These images enable high-definition axial, coronal, and sagittal reconstructions, as well as advanced imaging techniques, including minimum intensity projection images a...
Source: Clinics in Chest Medicine - April 10, 2015 Category: Respiratory Medicine Authors: Maria Shiau, Timothy J. Harkin, David P. Naidich Source Type: research

Imaging the Solitary Pulmonary Nodule
The development of widespread lung cancer screening programs has the potential to dramatically increase the number of thoracic computed tomography (CT) examinations performed annually in the United States, resulting in a greater number of newly detected, indeterminate solitary pulmonary nodules (SPNs). Additional imaging studies, such as fluorodeoxyglucose F 18 (FDG)–positron emission tomography (PET), have been shown to provide valuable information in the assessment of indeterminate SPNs. Newer technologies, such as contrast-enhanced dual-energy chest CT and FDG-PET/CT, also have the potential to facilitate diagnosis of...
Source: Clinics in Chest Medicine - April 10, 2015 Category: Respiratory Medicine Authors: Jeffrey B. Alpert, Conor M. Lowry, Jane P. Ko Source Type: research

Associations of circulating natriuretic peptides with haemodynamics in precapillary pulmonary hypertension
While N-terminal B-type natriuretic peptide (NT-proBNP) has been examined extensively in pulmonary hypertension (PH), limited data exists on the subtype A, C and D. The aim of this prospective pilot study was a head-to-head comparison of NPs in respect to haemodynamic parameters and the influence of renal function. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 10, 2015 Category: Respiratory Medicine Authors: Ralf Kaiser, Katharina Grotemeyer, Philipp Lepper, Caroline Stokes, Robert Bals, Heinrike Wilkens Source Type: research

HbA1c as a screening tool for cystic fibrosis related diabetes
Early diagnosis of cystic fibrosis (CF) related diabetes (CFRD) is important to improve outcomes. International guidelines recommend an oral glucose tolerance test (OGTT) for all CF patients aged ≥10years — this approach is controversial. The aim of this study was to develop an effective screening tool and reduce the need for a universal OGTT. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 10, 2015 Category: Respiratory Medicine Authors: Juliana C. Burgess, Nicola Bridges, Winston Banya, Khin M. Gyi, Margaret E. Hodson, Diana Bilton, Nicholas J. Simmonds Tags: Original Article Source Type: research

Cystic fibrosis transmembrane conductance regulator gene variants are associated with autoimmune pancreatitis and slow response to steroid treatment
Autoimmune pancreatitis (AIP) is a distinct type of chronic pancreatitis. To date, the association of CFTR gene variants with AIP has not been studied. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 10, 2015 Category: Respiratory Medicine Authors: Ming-Chu Chang, I-Shiow Jan, Po-Chin Liang, Yung-Ming Jeng, Ching-Yao Yang, Yu-Wen Tien, Jau-Min Wong, Yu-Ting Chang Tags: Original Article Source Type: research

Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis
High-dose ibuprofen (HDI) is a clinically beneficial anti-inflammatory regimen that may be a useful reagent to study induced sputum inflammatory marker changes over short study periods appropriate for early-phase CF clinical trials. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 10, 2015 Category: Respiratory Medicine Authors: James F. Chmiel, Michael W. Konstan, Frank J. Accurso, James Lymp, Nicole Mayer-Hamblett, Donald R. VanDevanter, Lynn M. Rose, Bonnie W. Ramsey Tags: Original Article Source Type: research

Airway extravasation induced by increasing airway temperature in ovalbumin-sensitized rats
This study was carried out to determine whether hyperventilation of humidified warm air (HWA) induced airway extravasation in ovalbumin (Ova)-sensitized rats. Our results showed: 1) After isocapnic hyperventilation with HWA for 2min, tracheal temperature (Ttr) was increased to 40.3°C, and the Evans blue contents in major airways and lung tissue were elevated to 651% and 707%, respectively, of that after hyperventilation with humidified room air in Ova-sensitized rats; this striking effect of HWA was absent in control rats. 2) The HWA-induced increase in Evans blue content in sensitized rats was completely prevented by a p...
Source: Respiratory Physiology and Neurobiology - April 10, 2015 Category: Respiratory Medicine Source Type: research

Effects of lipopolysaccharide-induced inflammation on initial lung fibrosis during open-lung mechanical ventilation in rats
This study aimed to assess the impact of pulmonary inflammation on early fibrotic response in rats challenged with increasing doses of lipopolysaccharide (LPS). Twenty-four rats were randomized and infused with three different increasing doses of continuous LPS infusion (n=8/group) while being ventilated with low tidal volumes and open-lung positive end-expiratory pressure. Another 8 animals served as uninjured control group. Hemodynamics, gas exchange, respiratory system mechanics, lung histology, α-smooth muscle actin, plasma cytokines, and mRNA expression of cytokines and type I and III procollagen in lung tissue were ...
Source: Respiratory Physiology and Neurobiology - April 10, 2015 Category: Respiratory Medicine Source Type: research

Reply to Dr. S.A. Ward: Whipp's law, Comroe's law and generality of the optimization model of ventilatory control
Publication date: Available online 9 April 2015 Source:Respiratory Physiology &amp; Neurobiology Author(s): Chi-Sang Poon (Source: Respiratory Physiology and Neurobiology)
Source: Respiratory Physiology and Neurobiology - April 10, 2015 Category: Respiratory Medicine Source Type: research

Lung transplant: Complications and quality of life
Publication date: Available online 10 April 2015 Source:Revista Portuguesa de Pneumologia (English Edition) Author(s): A.V. Cardoso , H.N. Bastos , C. Damas (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - April 10, 2015 Category: Respiratory Medicine Source Type: research