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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Exhaled breath condensate in intubated neonates--a window into the lung's glutathione status.
CONCLUSIONS: GSH status in EBC samples of intubated newborns significantly correlated with the GSH status of the TA sample and was reflective of cellular GSH status in this cohort of neonatal patients. Non-invasive EBC sampling of intubated newborns holds promise for monitoring antioxidant status such as GSH in the premature lung. Further studies are necessary to evaluate the potential relationships between EBC biomarkers in the intubated premature newborn and respiratory morbidities. PMID: 24397246 [PubMed - indexed for MEDLINE] (Source: Respiratory Care)
Source: Respiratory Care - October 12, 2014 Category: Respiratory Medicine Authors: Rosso MI, Roark S, Taylor E, Ping X, Ward JM, Roche K, McCracken C, Brown LA, Gauthier TW Tags: Respir Res Source Type: research

Intercostal and forearm muscle deoxygenation during respiratory fatigue in patients with heart failure: potential role of a respiratory muscle metaboreflex.
Abstract The purpose of this study was to determine the effect of respiratory muscle fatigue on intercostal and forearm muscle perfusion and oxygenation in patients with heart failure. Five clinically stable heart failure patients with respiratory muscle weakness (age, 66±12 years; left ventricle ejection fraction, 34±3%) and nine matched healthy controls underwent a respiratory muscle fatigue protocol, breathing against a fixed resistance at 60% of their maximal inspiratory pressure for as long as they could sustain the predetermined inspiratory pressure. Intercostal and forearm muscle blood volume and oxygenati...
Source: Braz J Med Biol Res - October 12, 2014 Category: Research Authors: Moreno AM, Castro RR, Silva BM, Villacorta H, Junior MS, Nóbrega AC Tags: Braz J Med Biol Res Source Type: research

Cigarette Smoke-Exposed Candida albicans Increased Chitin Production and Modulated Human Fibroblast Cell Responses.
Abstract The predisposition of cigarette smokers for development of respiratory and oral bacterial infections is well documented. Cigarette smoke can also contribute to yeast infection. The aim of this study was to investigate the effect of cigarette smoke condensate (CSC) on C. albicans transition, chitin content, and response to environmental stress and to examine the interaction between CSC-pretreated C. albicans and normal human gingival fibroblasts. Following exposure to CSC, C. albicans transition from blastospore to hyphal form increased. CSC-pretreated yeast cells became significantly (P < 0.01) sensitiv...
Source: Biomed Res - October 12, 2014 Category: Research Authors: Alanazi H, Semlali A, Perraud L, Chmielewski W, Zakrzewski A, Rouabhia M Tags: Biomed Res Int Source Type: research

Cost-effectiveness of initiating extrafine- or standard size-particle inhaled corticosteroid for asthma in two health-care systems: a retrospective matched cohort study.
CONCLUSIONS: Initiating ICS therapy for asthma as extrafine-particle ICS seems the dominant treatment option (less costly and more effective) compared with standard size-particle ICS in both the UK and the US. PMID: 25297072 [PubMed - in process] (Source: Primary Care)
Source: Primary Care - October 12, 2014 Category: Primary Care Authors: Martin RJ, Price D, Roche N, Israel E, van Aalderen WM, Grigg J, Postma DS, Guilbert TW, Hillyer EV, Burden A, von Ziegenweidt J, Colice G Tags: NPJ Prim Care Respir Med Source Type: research

Respiratory medication use in an Australian developmental disability clinic population: messages for health care professionals.
This study describes respiratory medication use, reported prevalence of asthma, and asthma management practices undertaken in a clinic sample of Australian adults with ID. Results showed a prevalence of retrospectively reported asthma of 6%, with 86% of asthma patients prescribed inhaled medication. A review of patient records also indicated omission of some recommended asthma management strategies. PMID: 23693140 [PubMed - indexed for MEDLINE] (Source: Primary Care)
Source: Primary Care - October 12, 2014 Category: Primary Care Authors: Davis SR, Durvasula S, Merhi D, Young PM, Traini D, Bosnic-Anticevich SZ Tags: Aust J Prim Health Source Type: research

Comparison of innate immune agonists for induction of tracheal antimicrobial peptide gene expression in tracheal epithelial cells of cattle
Bovine respiratory disease is a complex of bacterial and viral infections of economic and welfare importance to the beef industry. Although tracheal antimicrobial peptide (TAP) has microbicidal activity against bacterial pathogens causing bovine respiratory disease, risk factors for bovine respiratory disease including BVDV and stress (glucocorticoids) have been shown to inhibit the induced expression of this gene. Lipopolysaccharide is known to stimulate TAP gene expression, but the maximum effect is only observed after 16?h of stimulation. The present study investigated other agonists of TAP gene expression in primary cu...
Source: BioMed Central - October 12, 2014 Category: Journals (General) Authors: Lesley BerghuisKhaled T AbdelazizJodi BierworthLeanna WyerGabriella JacobNiel A KarrowShayan SharifMary E ClarkJeff L Caswell Source Type: research

The association of plasma biomarkers with computed tomography-assessed emphysema phenotypes
RationaleChronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer. High resolution computed tomography (HRCT) scans are useful in quantifying emphysema but are associated with radiation exposure and high incidence of false positive findings (i.e., nodules). Using a comprehensive biomarker panel, we sought to determine if there was a peripheral blood biomarker signature of emphysema. Methods: 114 plasma biomarkers were measured using a custom assay in 588 individuals enrolled in the COPDGene study...
Source: Respiratory Research - October 12, 2014 Category: Respiratory Medicine Authors: Brendan CarolanGrant HughesJarrett MorrowCraig HershWanda O¿NealStephen RennardSreekumar PillaiPaula BelloniDebra CockayneAlejandro ComellasMeilan HanRachel ZemansKaterina KechrisRussell Bowler Source Type: research

The value of non-invasive ventilation
Non-invasive ventilation (NIV) use has increased markedly over the last 10 years. Children being treated with NIV are now a common sight in most paediatric intensive care units and high dependency units and nearly all tertiary respiratory units will look after a cohort of children who use NIV at home. Although the published evidence base for use of NIV in acute and chronic respiratory failure is relatively weak, it is now very unlikely that there will be any more randomised controlled trials of this intervention. Effectiveness of NIV will need to be evaluated on each child as it used. It is important to define the purpose ...
Source: Archives of Disease in Childhood - October 12, 2014 Category: Pediatrics Authors: Hull, J. Tags: Clinical trials (epidemiology) Review Source Type: research

When two trials conflict: bronchiolitis and hypertonic saline
The editors of JAMA Pediatrics must have been flummoxed when they received two papers at the same time describing the same interventional trial, with completely different results. Both were trials comparing 3% with 0.9% nebulised saline in bronchiolitis, and both were conducted in the emergency departments (EDs) of US children's hospitals. The editors took the brave decision to publish them simultaneously with an accompanying editorial. Both trials recruited infants under two years presenting to ED with a first episode of clinically diagnosed bronchiolitis, and both excluded those with pre-existing cardio-respiratory condi...
Source: Archives of Disease in Childhood - October 12, 2014 Category: Pediatrics Tags: Miscellanea Source Type: research

Towards evidence based medicine for paediatricians
More than lucky When two people/researchers/clinicians are looking at something, we often want to know if they are seeing/deciding the same thing. It has been said (but not by me, who relies on them too much) that two radiologists reviewing the same chest radiograph will have three different opinions on if there's pneumonia or not. Measuring the amount of agreement is often done using the statistic. is a measure of agreement, usually between two observers of a dichotomous outcome although there are variants for multiple observers. It gives you a measure of what agreement you see that is ‘beyond chance’ Take an ...
Source: Archives of Disease in Childhood - October 12, 2014 Category: Pediatrics Authors: Phillips, B. Tags: ADC Archimedes, Journalology, Pneumonia (infectious disease), TB and other respiratory infections, Radiology, Pneumonia (respiratory medicine), Clinical diagnostic tests, Radiology (diagnostics), Competing interests (ethics) Source Type: research

Actinotalea suaedae sp. nov., isolated from the halophyte Suaeda physophora in Xinjiang, Northwest China.
Abstract A Gram-stain-positive, aerobic, non-motile, coryneform bacterium, designated strain EGI 60002(T), was isolated from the halophyte Suaeda physophora. Cells were coryneform shaped and polymorphic. Phylogenetic analysis based on 16S rRNA gene sequences showed that the new isolate was closely related to Actinotalea ferrariae CF5-4(T) (95.8 % gene sequence similarity). The peptidoglycan type of strain EGI 60002(T) was A4β, containing L-Orn-D-Ser-D-Asp. The cell-wall sugars were mannose, ribose, rhamnose and glucose. The major fatty acids (>5 %) of strain EGI 60002(T) were iso-C14:0, iso-C15:0, anteiso-C15...
Source: Antonie van Leeuwenhoek - October 12, 2014 Category: Microbiology Authors: Zhao S, Li L, Li SH, Wang HF, Hozzein WN, Zhang YG, Wadaan MA, Li WJ, Tian CY Tags: Antonie Van Leeuwenhoek Source Type: research

Comparison of innate immune agonists for induction of tracheal antimicrobial peptide gene expression in tracheal epithelial cells of cattle
Abstract Bovine respiratory disease is a complex of bacterial and viral infections of economic and welfare importance to the beef industry. Although tracheal antimicrobial peptide (TAP) has microbicidal activity against bacterial pathogens causing bovine respiratory disease, risk factors for bovine respiratory disease including BVDV and stress (glucocorticoids) have been shown to inhibit the induced expression of this gene. Lipopolysaccharide is known to stimulate TAP gene expression, but the maximum effect is only observed after 16 h of stimulation. The present study investigated other agonists of TAP gene expr...
Source: Veterinary Research - October 12, 2014 Category: Veterinary Research Source Type: research

Drowning and immersion injury
Publication date: September 2014 Source:Anaesthesia &amp; Intensive Care Medicine, Volume 15, Issue 9 Author(s): F. Eduardo Martinez , Andrew J. Hooper Drowning is a process resulting in primary respiratory impairment from submersion/immersion in a liquid medium. It is a frequent cause of unintentional injury deaths and public health initiatives to prevent drowning are important as there are no specific interventions proven to improve outcomes in drowning victims. Risk factors for drowning include inadequate supervision, recreational or occupational access to water, risk-taking behaviour and underlying medical condit...
Source: Anaesthesia and intensive care medicine - October 12, 2014 Category: Anesthesiology Source Type: research

Pediatric Ambulatory Anesthesia
This article discusses several common preoperative dilemmas, including whether to postpone anesthesia when a child has an upper respiratory infection, whether to test young women for pregnancy, which children require overnight admission for apnea monitoring, and the effectiveness of nonpharmacological techniques for reducing anxiety. Medication issues covered include the risks of anesthetic agents in children with undiagnosed weakness, the use of remifentanil for tracheal intubation, and perioperative dosing of rectal acetaminophen. The relative merits of caudal and dorsal penile nerve block for pain after circumcision are...
Source: Anesthesiology Clinics - October 12, 2014 Category: Anesthesiology Source Type: research

Burkholderia cepacia complex isolation in non-polypoid chronic rhinosinusitis
Conclusions The novel finding of Bcc species in CRS without polyposis as well suggests that the mechanism by which these bacteria adhere to the epithelium of the upper respiratory tract may be important in the host’s colonization. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - October 12, 2014 Category: Endocrinology Source Type: research

The safety of tracheostomy speaking valve use during sleep in children: A pilot study
Conclusion This pilot study reveals that use of a tracheostomy-speaking valve during sleep, was not associated with adverse cardiopulmonary events. This is the first study to show that a tracheostomy-speaking valve might be safely used during sleep, in children. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - October 12, 2014 Category: Endocrinology Source Type: research

A case of congenital aplasia of the epiglottis in an adult
We present a case of congenital absence of the epiglottis found in a 33-year-old woman complaining of recurrent lingual tonsillitis. Laryngoscopic finding and CT scan revealed an isolated epiglottic aplasia and normal appearance of other laryngeal structure. This is the first description of physiologic evaluation in an epiglottic anomaly to find the compensatory mechanism of aspiration prevention. We discussed this case with a review of literature. (Source: American Journal of Otolaryngology)
Source: American Journal of Otolaryngology - October 12, 2014 Category: Endocrinology Source Type: research

Surveillance for respiratory health care–associated infections among inpatients in 3 Kenyan hospitals, 2010-2012
Conclusion We identified rHAIs in all ward types under surveillance in Kenyan hospitals. Viruses may have a substantial role in these infections, particularly among pediatric populations. Further research is needed to refine case definitions and understand rHAIs in ICUs. (Source: American Journal of Infection Control)
Source: American Journal of Infection Control - October 12, 2014 Category: Infectious Diseases Source Type: research

Legalizing Cannabis: A physician’s primer on the pulmonary effects of marijuana
Abstract Habitual smoking of marijuana is associated with multiple respiratory symptoms such as cough, sputum production, and wheezing .These symptoms are not significantly different from those exhibited by tobacco smokers. Furthermore, endobronchial biopsies of habitual smokers of marijuana and /or tobacco have shown that both marijuana and cigarette smoking cause significant bronchial mucosal histopathology and that these effects are additive. Although marijuana smokers have minimal changes in pulmonary function studies as compared to tobacco smokers, they may develop bullous disease and spontaneous pneumothorac...
Source: Current Respiratory Care Reports - October 11, 2014 Category: Respiratory Medicine Source Type: research

Virologic testing in bronchiolitis: does it change management decisions and predict outcomes?
Conclusion: Although RSV bronchiolitis has a more severe clinical course, virologic testing does not help in management decisions, and at an individual level, as a performance test, it seems insufficient to precisely predict outcomes. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Prediction of the risk of coronary arterial lesions in Kawasaki disease by serum 25-hydroxyvitamin D 3
Conclusion: Serum 25-(OH)D3 levels were elevated dur-ing the acute phase in KD children who had subsequent CALs. Serum 25-(OH)D3 levels in the acute phase of KD may be used to predict subsequent CALs. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Lung function of preterm infants before and after viral infections
Conclusion: These results suggest viral LRTIs, regardless of whether hospitalisation is required, adversely affect prematurely born infants’ airway resistance at follow up. (Source: European Journal of Pediatrics)
Source: European Journal of Pediatrics - October 11, 2014 Category: Pediatrics Source Type: research

Sudden unexpected death in epilepsy: addressing the challenges.
Abstract Epilepsy is associated with a higher rate of premature death than the general population, and the commonest cause of epilepsy mortality is sudden unexpected death in epilepsy (SUDEP). It is difficult to quantify because of the variable reporting of this cause of death. Death occurs due to autonomic deregulation of cardio-respiratory pathways as a result of seizures. Measures to reduce cardio-respiratory dysfunction are discussed together with the importance of seizure control in preventing SUDEP. The role of seizure detection devices, antiepileptic drugs and the importance of providing information about SU...
Source: Epilepsy Curr - October 11, 2014 Category: Neurology Authors: Smithson WH, Colwell B, Hanna J Tags: Curr Neurol Neurosci Rep Source Type: research

Human parvovirus B19: A review.
Abstract UNLABELLED: Parvovirus B19 (B19V) is a small non-enveloped single-stranded DNA (ssDNA) virus of the family Parvoviridae, the subfamily Parvovirinae, the genus Erythrovirus and Human parvovirus B19 type species. It is a common community-acquired respiratory pathogen without ethnic, socioeconomic, gender, age or geographic boundaries. Moreover, the epidemiological and ecological relationships between human parvovirus B19, man and environment have aroused increasing interest in this virus. B19V infection is associated with a wide spectrum of clinical manifestations, some of which were well established and ...
Source: Acta Virologica - October 11, 2014 Category: Infectious Diseases Authors: Rogo LD, Mokhtari-Azad T, Kabir MH, Rezaei F Tags: Acta Virol Source Type: research

An intriguing finding in the right atrium
A 67-year-old male presented with shortness of breath, exacerbated by standing up and walking around and alleviated upon lying down. There was no associated coughing or chest pain. His medical history was notable for chronic alcohol abuse, chronic obstructive pulmonary disease and two recent admissions for aspiration pneumonitis. An inferior vena cava (IVC) filter had been placed 10 years earlier due to a pulmonary embolism. He denied illicit drug use. He was not taking any regular medications. On physical examination: T 97.6, P 100, BP 101/70, RR 30, O2 sat 95% supine and 91% upright on room air. He looked dishevelle...
Source: Heart - October 11, 2014 Category: Cardiology Authors: Schwartzenberg, S., Passeri, J. J. Tags: Image challenges, Venous thromboembolism, Clinical diagnostic tests Source Type: research

[Case Report] Dyspnoea, weight loss, fever, and headache caused by extrapulmonary tuberculosis in a prison inmate
A 55-year-old Panamanian man was referred from a penitentiary clinic to Hospital Santo Tomás in March, 2014. He presented with a 10-day history of breathing difficulty, chest pain, fever, headache, and had also lost more than 10 kg in weight over the previous 2 months. His medical and family history was unremarkable; however, he reported that he had been in contact with inmates who had had chronic cough for 2 years. The patient's vital signs were normal, apart from a respiratory rate of 28 breaths per min. (Source: LANCET)
Source: LANCET - October 11, 2014 Category: Journals (General) Authors: Musharaf Tarajia, Fabio Jaramillo, Amaranta Pernett, Nelson Santamaría, Amador Goodridge Tags: Case Report Source Type: research

Cold Spells and the Risk of Hospitalization for Asthma: New York, USA 1991–2006
Conclusions The results suggest that during prolonged periods of severe cold asthmatics may adhere to medical guidelines and limit their exposure, thereby preventing exacerbations. They may be less likely to alter their behavior in the more moderate months of November and April. (Source: Lung)
Source: Lung - October 11, 2014 Category: Respiratory Medicine Source Type: research

Nationwide patient registry for GNE myopathy in Japan
Conclusion: The Japanese Remudy-GNE myopathy is useful for clarifying the natural history of the disease and recruiting patients with genetically-confirmed GNE myopathy for clinical trials. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - October 11, 2014 Category: Internal Medicine Authors: Madoka Mori-YoshimuraYukiko HayashiNaohiro YonemotoHarumasa NakamuraMiho MurataShin¿ichi TakedaIchizo NishinoEn Kimura Source Type: research

Characterization of the chaperonin GroEL in Mycoplasma gallisepticum.
This study is the first report of the biological characterization of chaperone GroEL protein in MG. PMID: 25304689 [PubMed - as supplied by publisher] (Source: Archives of Microbiology)
Source: Archives of Microbiology - October 11, 2014 Category: Microbiology Authors: Tan L, Hu M, Yu S, Wang X, Lu F, Liu F, Qiu X, Song C, Sun Y, Ding C Tags: Arch Microbiol Source Type: research

Beyond the whole genome consensus: Unravelling of PRRSV phylogenomics using next generation sequencing technologies.
Abstract The highly heterogeneous porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent responsible for an economically important pig disease with the characteristic symptoms of reproductive losses in breeding sows and respiratory illnesses in young piglets. The virus can be broadly divided into the European and North American-like genotype 1 and 2 respectively. In addition to this intra-strains variability, the impact of coexisting viral quasispecies on disease development has recently gained much attention; owing very much to the advent of the next-generation sequencing (NGS) technolo...
Source: Virus Research - October 11, 2014 Category: Virology Authors: Lu ZH, Archibald AL, Ait-Ali T Tags: Virus Res Source Type: research

Cost-effectiveness of CPAP treatment related to cardiovascular disease in patients with severe OSAS: the Greek experience
(Source: Sleep and Breathing)
Source: Sleep and Breathing - October 10, 2014 Category: Respiratory Medicine Source Type: research

RSV and its propensity for causing bronchiolitis
Abstract Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, i.e., bronchiolitis. The most common eitological agents causing bronchiolitis in young children are the respiratory viruses and of the commonly encountered respiratory viruses, Respiratory Syncytial Virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of ...
Source: The Journal of Pathology - October 10, 2014 Category: Pathology Authors: Raymond J Pickles, John DeVincenzo Tags: Invited Review Source Type: research

Comparison of PNA clamping and direct sequencing for detecting KRAS mutations in matched tumour tissue, cell block, pleural effusion and serum from patients with malignant pleural effusion
ConclusionsThe current study suggests that PNA clamping had a good concordance with direct sequencing for the detection of KRAS mutation in patients with malignant effusion. Furthermore, the good diagnostic performance obtained from pleural effusion samples provides evidence that pleural effusion can be a useful source for detecting KRAS mutation in a clinical setting, in which the collection of tumour tissues is challenging. (Source: Respirology)
Source: Respirology - October 10, 2014 Category: Respiratory Medicine Authors: Ji Young Kang, Chan Kwon Park, Chang Dong Yeo, Hea Yeon Lee, Chin Kook Rhee, Seung Joon Kim, Seok Chan Kim, Young Kyoon Kim, Mi Sun Park, Hyeon Woo Yim Tags: Original Article Source Type: research

Increased activation of blood neutrophils after cigarette smoking in young individuals susceptible to COPD
Conclusions: We show for the first time that COPD susceptibility at young age associates with an increased systemic innate immune response to cigarette smoking. This suggests a role of systemic inflammation in the early induction phase of COPD.Trial registrationClinicaltrials.gov: NCT00807469 (Source: Respiratory Research)
Source: Respiratory Research - October 10, 2014 Category: Respiratory Medicine Authors: Susan HoonhorstWim TimensLeo KoendermanAdèle Lo Tam LoiJan-Willem LammersH BoezenAntoon van OosterhoutDirkje PostmaNick ten Hacken Source Type: research

Comparing early years and childhood experiences and outcomes in Scotland, England and three city-regions: a plausible explanation for Scottish 'excess' mortality?
Conclusion: Based on these samples, the study does not support the hypothesis that EYCE were worse in Scotland and Glasgow and the Clyde Valley. It seems, therefore (based on these data), less likely that the roots of the excess mortality observed in the Scottish areas can be explained by these factors. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - October 10, 2014 Category: Epidemiology Authors: Martin TaulbutDavid WalshJohn O¿Dowd Source Type: research

Public reporting improves antibiotic prescribing for upper respiratory tract infections in primary care: a matched-pair cluster-randomized trial in China
Conclusions: The results suggest that PR could improve prescribing practices in terms of reducing oral antibiotics and combined use of antibiotics; however, the impacts were limited. We suggest that PR would probably be enhanced by provider payment reform, management and training for providers, and health education for patients. (Source: Health Research Policy and Systems)
Source: Health Research Policy and Systems - October 10, 2014 Category: Global & Universal Authors: Lianping YangChaojie LiuLijun WangXi YinXinping Zhang Source Type: research

Retrospective observational study of patients who present to Australian rural emergency departments with undifferentiated chest pain
ConclusionsThis study has provided information on the characteristics and processes of care for patients presenting to Australian rural EDs with undifferentiated chest pain that will inform service planning and further research to evaluate the effectiveness of care for these patients. (Source: Australian Journal of Rural Health)
Source: Australian Journal of Rural Health - October 10, 2014 Category: Rural Health Authors: Tina Roche, Glenn Gardner, Peter Lewis Tags: Original Research Source Type: research

Omega‐3 Fatty Acid Supplementation Provides an Additional Benefit to a Low‐Dust Diet in the Management of Horses with Chronic Lower Airway Inflammatory Disease
Conclusions and Clinical ImportanceFeeding horses with RAO and IAD a PUFA supplement containing 1.5–3 g DHA for 2 months provides an additional benefit to low‐dust diet. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: N. Nogradi, L.L. Couetil, J. Messick, M.A. Stochelski, J.R. Burgess Tags: Standard Article Source Type: research

Relationship of Plasma N‐terminal Pro‐brain Natriuretic Peptide Concentrations to Heart Failure Classification and Cause of Respiratory Distress in Dogs Using a 2nd Generation ELISA Assay
Conclusions and Clinical ImportancePlasma [NT‐proBNP] was useful for discriminating CHF from noncardiac respiratory distress. Average plasma [NT‐BNP] increased significantly as a function of HD severity using the ACVIM‐HD classification scheme. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - October 10, 2014 Category: Veterinary Research Authors: P.R. Fox, M.A. Oyama, M.J. Hezzell, J.E. Rush, T.P. Nguyenba, T.C. DeFrancesco, L.B. Lehmkuhl, H.B. Kellihan, B. Bulmer, S.G. Gordon, S.M. Cunningham, J. MacGregor, R.L. Stepien, B. Lefbom, D. Adin, K. Lamb Tags: Standard Article Source Type: research

α-Hemolysin Activity of Methicillin-Susceptible S. aureus Predicts Ventilator-Associated Pneumonia.
Conclusions. MSSA strains with strong blood-agar hemolysis and high alpha-hemolysin activity are markers for VAP, but not VAT and, might be considered in differential diagnosis and initiation of therapy. PMID: 25303310 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Stulik L, Malafa S, Hudcova J, Rouha H, Henics BZ, Craven DE, Sonnevend AM, Nagy E Tags: Am J Respir Crit Care Med Source Type: research

Risk Assessment of Tuberculosis in Immunocompromised Patients - A TBNET Study.
Conclusions: Among immunocompromised patients evaluated in this study, progression towards tuberculosis was highest in HIV-infected individuals and was poorly predicted by TST or IGRAs Clinical trial registration information available at www.clinicaltrials.gov, ID NCT00707317. PMID: 25303140 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 10, 2014 Category: Respiratory Medicine Authors: Sester M, van Leth F, Bruchfeld J, Bumbacea D, Cirillo DM, Gorek Dilektasli A, Domínguez J, Duarte R, Ernst M, Oner Eyuboglu F, Gerogianni I, Girardi E, Goletti D, Janssens JP, Julander I, Lange B, Latorre I, Losi M, Markova R, Matteelli A, Milburn H, Ra Tags: Am J Respir Crit Care Med Source Type: research

PDGF Signaling in the Lung - From Lung Development and Disease to Clinical Studies.
In conclusion, while PDGF inhibition is currently used in multiple clinical trials, we suggest that more elaborate and specific approaches for spatio-temporal control of PDGF signaling are required for developing personalized approaches involving PDGF signaling in lung disease. PMID: 25303647 [PubMed - as supplied by publisher] (Source: Am J Respir Cell Mol...)
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Noskovičová N, Petřek M, Eickelberg O, Heinzelmann K Tags: Am J Respir Cell Mol Biol Source Type: research

Thrombin Down-Regulates Tissue Factor Pathway Inhibitor Expression in a PI3K/NFκB-Dependent Manner in Human Pleural Mesothelial Cells.
Abstract Tissue factor pathway inhibitor (TFPI) is the primary inhibitor of the extrinsic coagulation cascade and its expression is reported to be relatively stable. Various pathophysiologic agents have been shown to influence TFPI activity either by regulating its expression or modifying the protein. It is not clear how TFPI activity is regulated in normal physiology or in injury. Because thrombin and TFPI are both locally elaborated in pleural injury, we sought to determine if thrombin could regulate TFPI in human pleural mesothelial cells (HPMCs). Thrombin significantly decreased TFPI mRNA and protein levels by ...
Source: Am J Respir Cell Mol... - October 10, 2014 Category: Respiratory Medicine Authors: Jeffers A, Owens S, Koenig K, Quaid B, Pendurthi UR, Rao LV, Idell S, Tucker TA Tags: Am J Respir Cell Mol Biol Source Type: research