Medicine RSS Search Engine

Respiratory Medicine Respiratory Medicine RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Pulmonary manifestations of pyoderma gangrenosum: 2 cases and a review of the literature
Pyoderma gangrenosum (PG) is a rare ulcerative neutrophilic dermatologic disease that occasionally is accompanied by extracutaneous manifestations, amongst these is pulmonary involvement. The etiology is unknown. More than 50% of PG cases are associated with an underlying systemic disease such as inflammatory bowel disease, rheumatoid arthritis, hematological disorder or malignancy. Extracutaneous manifestations are rare and only 29 cases of pulmonary involvement have been reported previously in the literature. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - January 23, 2015 Category: Respiratory Medicine Authors: Melina Gade, Frej Studstrup, Anne Kathrine Andersen, Ole Hilberg, Carsten Fogh, Elisabeth Bendstrup Tags: Review Source Type: research

A comprehensive database of Duchenne and Becker muscular dystrophy patients (0¿18 years old) in East China
Conclusions: The database is the first linking accurate genetic diagnosis with clinical manifestation and treatment status of dystrophinopathy patients in East China. It provides comprehensive information essential for further patient management, especially for promotion of international cooperation in developing experimental therapies such as exon skipping and read-through of nonsense mutations targeting a subgroup of DMD patient population. (Source: Orphanet Journal of Rare Diseases)
Source: Orphanet Journal of Rare Diseases - January 23, 2015 Category: Internal Medicine Authors: Xihua LiLei ZhaoShuizhen ZhouChaoping HuYiyun ShiWei ShiHui LiFang LiuBingbing WuYi Wang Source Type: research

The Intersection of the Extrinsic Hedgehog and WNT/Wingless Signals with the Intrinsic Hox Code Underpins Branching Pattern and Tube Shape Diversity in the Drosophila Airways
by Ryo Matsuda, Chie Hosono, Kaoru Saigo, Christos Samakovlis The tubular networks of the Drosophila respiratory system and our vasculature show distinct branching patterns and tube shapes in different body regions. These local variations are crucial for organ function and organismal fitness. Organotypic patterns and tube geometries in branched networks are typically controlled by variations of extrinsic signaling but the impact of intrinsic factors on branch patterns and shapes is not well explored. Here, we show that the intersection of extrinsic hedgehog(hh) and WNT/wingless (wg) signaling with the tube-intrinsic Hox c...
Source: PLoS Genetics - January 23, 2015 Category: Genetics & Stem Cells Authors: Ryo Matsuda et al. Source Type: research

Prospective and retrospective evaluation of the Cepheid Xpert Flu/RSV XC assay for rapid detection of influenza A, influenza B, and Respiratory Syncytial virus
A total of 281 clinical specimens (nasal swabs, nasopharyngeal aspirates) were tested with the Xpert® Flu/RSV XC. The results were compared to those obtained with the rt-RT-PCR assays routinely used in our laboratory. The Xpert® Flu/RSV XC showed sensitivity/specificity of 97.8%/100% and 97.9%/100% for Flu and RSV respectively. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - January 23, 2015 Category: Microbiology Authors: Nicolas Salez, Antoine Nougairede, Laetitia Ninove, Christine Zandotti, Xavier de Lamballerie, Remi N. Charrel Source Type: research

Worker illness related to newly marketed pesticides - douglas county, washington, 2014.
Abstract On April 10, 2014 the Washington State Department of Agriculture (WSDA) was notified by a local newspaper of a suspected pesticide poisoning incident in Douglas County involving pesticides not previously reported in the published literature to be associated with human illness. On that same day, WSDA notified the Washington State Department of Health, which investigated this incident by conducting a site visit, reviewing medical and applicator records, and interviewing affected farmworkers, pesticide applicators, and the farmworkers' employer. In addition, on April 11, WSDA collected swab, foliage, and clot...
Source: MMWR Morb Mortal Wkl... - January 23, 2015 Category: Epidemiology Authors: Calvert GM, Rodriguez L, Prado JB Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Clinical associations of host genetic variations in the genes of cytokines in critically ill patients
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 23, 2015 Category: Allergy & Immunology Authors: Olesya B. Belopolskaya, Tamara V. Smelaya, Viktor V. Moroz, Arkady M. Golubev, Lyubov E. Salnikova Tags: Original Article Source Type: research

Inflammatory impact of IFN-γ in CD8+ T-cell-mediated lung injury is mediated by both Stat1-dependent and -independent pathways.
Abstract Influenza infection results in considerable pulmonary pathology, a significant component of which is mediated by CD8(+) T cell effector functions. To isolate the specific contribution of CD8(+) T cells to lung immunopathology, we utilized a non-viral murine model in which alveolar epithelial cells express an influenza antigen and injury is initiated by adoptively transferring influenza-specific CD8(+) T cells. Here, we report that IFN-γ production by adoptively transferred influenza-specific CD8(+) T cells is a significant contributor to acute lung injury following influenza antigen recognition, in isolat...
Source: Am J Physiol Lung Ce... - January 23, 2015 Category: Respiratory Medicine Authors: Ramana CV, DeBerge MP, Kumar A, Alia CS, Durbin JE, Enelow RI Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Prevention of pulmonary hypoplasia and pulmonary vascular remodeling by antenatal simvastatin treatment in nitrofen-induced congenital diaphragmatic hernia.
PREVENTION OF PULMONARY HYPOPLASIA AND PULMONARY VASCULAR REMODELING BY ANTENATAL SIMVASTATIN TREATMENT IN NITROFEN-INDUCED CONGENITAL DIAPHRAGMATIC HERNIA. Am J Physiol Lung Cell Mol Physiol. 2015 Jan 23;:ajplung.00345.2014 Authors: Makanga M, Maruyama H, Dewachter C, Mendes da Costa A, Hupkens E, de Medina G, Naeije R, Dewachter L Abstract Congenital diaphragmatic hernia (CDH) has a high mortality rate mainly due to lung hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Simvastatin has been shown to prevent the development of pulmonary hypertension (PH) in experimental models of...
Source: Am J Physiol Lung Ce... - January 23, 2015 Category: Respiratory Medicine Authors: Makanga M, Maruyama H, Dewachter C, Mendes da Costa A, Hupkens E, de Medina G, Naeije R, Dewachter L Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Alterations in Expression of Elastogenic and Angiogenic Genes by Different Conditions of Mechanical Ventilation in Newborn Rat Lung.
Abstract Mechanical ventilation is an important risk factor for development of bronchopulmonary dysplasia. Here we investigated the effects of different tidal volumes (VT) and duration of ventilation on expression of genes involved in alveolarization (tropoelastin (Eln), lysyloxidase-like 1 (Loxl1), fibulin5 (Fbln5) and tenascin-C (Tnc)) and angiogenesis (platelet derived growth factors (Pdgf) and vascular endothelial growth factors (Vegf) and their receptors) in eight-day old rats. First, pups were ventilated for 8 hours with low (LVT: 3.5 ml.kg(-1)), moderate (MVT: 8.5 ml.kg(-1)) or high (HVT: 25 ml.kg(-1)) tidal...
Source: Am J Physiol Lung Ce... - January 23, 2015 Category: Respiratory Medicine Authors: Kroon AA, Wang J, Post M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Occult alveolar hemorrhage in patient with bronchopulmonary Kaposi sarcoma.
PMID: 25622996 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 23, 2015 Category: Respiratory Medicine Authors: Martinez Ramirez I, Jose Luquez A, Garcia Herreros P Tags: Arch Bronconeumol Source Type: research

Behavior of Quality of Life (SGRQ) in COPD Patients According to BODE Scores.
CONCLUSION: There is an association between health-related quality of life, as assessed by the SGRQ and the BODE index within the entire spectrum of COPD severity. Even in early disease stages and BODE index zero, health-related quality of life is already impaired. PMID: 25622995 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - January 23, 2015 Category: Respiratory Medicine Authors: Nonato NL, Díaz O, Nascimento OA, Dreyse J, Jardim JR, Lisboa C Tags: Arch Bronconeumol Source Type: research

Diffusion-weighted imaging of the liver: comparison of image quality between monopolar and bipolar acquisition schemes at 3T
Conclusion In comparison with past studies performed at 1.5T, when using a modern 3T system, we observed improved image quality of liver DWI using a monopolar, rather than a bipolar, acquisition scheme, largely attributed to higher eSNR. (Source: Abdominal Imaging)
Source: Abdominal Imaging - January 22, 2015 Category: Radiology Source Type: research

Delafloxacin for the treatment of respiratory and skin infections
Expert Opinion on Investigational Drugs, Ahead of Print. (Source: Expert Opinion on Investigational Drugs)
Source: Expert Opinion on Investigational Drugs - January 22, 2015 Category: Drugs & Pharmacology Tags: article Source Type: research

Asthma in US Mexican-Origin Children in Early Childhood: Differences in Risk and Protective Factors by Parental Nativity
Conclusions Mexican-origin children experience a constellation of risk and protective factors, but those with US-born parents have elevated asthma risks compared to those with foreign-born parents. Asthma incidence and severity will likely increase as this population becomes increasingly integrated into US society. (Source: Academic Pediatrics)
Source: Academic Pediatrics - January 22, 2015 Category: Pediatrics Source Type: research

Trajectories of multimorbidity: exploring patterns of multimorbidity in patients with more than ten chronic health problems in life course
Conclusion: There are many challenges facing multimorbidity research, including the implementation of a longitudinal, life-time approach from a family practice perspective. The present study, although exploratory by nature, shows that both general and specific mechanisms characterize the development of multimorbidity trajectories. A very small proportion of patients has a very high number of chronic health problems (MM11+) and keeps adding health problems in their life. However, GP?s need to realise that more than one third of their patients accumulate four or more chronic health problems (MM4-5 and MM6-10) in their lifeti...
Source: BMC Family Practice - January 22, 2015 Category: Primary Care Authors: Rein VosMarjan van den AkkerJos BoestenCaroline RobertsonJob Metsemakers Source Type: research

The relationship between driving simulation performance and obstructive sleep apnoea risk, daytime sleepiness, obesity and road traffic accident history of commercial drivers in Turkey
Conclusions Cognitive-psychomotor functions can be impaired in obese and high risk of OSA patients. In our opinion, requiring obese and/or high risk of OSA drivers to take PTAS tests that assess driving skills and psychomotor-cognitive functions crucial to those skills would significantly improve road traffic safety, which is of considerable importance to public health. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Effect of different oxygen desaturation threshold levels on hypopnea scoring and classification of severity of sleep apnea
Conclusions The conventional AHI was found to be susceptible even to minor changes in ODT level which may lead to substantial variability in AHI-based classification of disease severity. Since the adjusted AHI comprises information on severity of individual breathing cessations, it reduces the variability related to ODT levels used in hypopnea scoring and can increase the accuracy of estimation of OSA severity. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Co-upregulation of Toll-like receptors 2 and 6 on peripheral blood cells in patients with obstructive sleep apnea
Conclusions OSA patients had increased TLR2/6 co-expressions on blood immune cells, which were related to their immune cell counts and could be reversed with CPAP treatment. In vitro IHR could induce TLR2/6 co-upregulation. (Source: Sleep and Breathing)
Source: Sleep and Breathing - January 22, 2015 Category: Respiratory Medicine Source Type: research

Effects of Polluted Air on Cardiovascular and Hematological Parameters After Progressive Maximal Aerobic Exercise
Conclusion Acute exposure to high concentrations of pollutants during exercise resulted in decline in cardiovascular functions and hematological parameters in healthy athletes. (Source: Lung)
Source: Lung - January 22, 2015 Category: Respiratory Medicine Source Type: research

Impact of a countywide smoke-free workplace law on emergency department visits for respiratory diseases: a retrospective cohort study
Conclusions: In Olmsted County, MN, asthma-related ED visits declined significantly after enactment of a smoke-free law. These results add to the body of literature supporting community health benefits of smoke-free policies in public environments and their potential to reduce health care costs. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - January 22, 2015 Category: Respiratory Medicine Authors: Ivana CroghanJon EbbertJames HaysDarrell SchroederAlanna ChamberlainVéronique RogerRichard Hurt Source Type: research

Integrating Pulmonary Rehabilitation into the Multidisciplinary Management of Lung Cancer: A Review
Lung cancer is the number one cause of cancer related deaths. It is increasingly recognized that a multidisciplinary approach to the diagnosis and management of patients with lung cancer represents the ideal model for health care delivery. Given the high incidence of comorbid lung disease in lung cancer patients, strategies targeted at improving or optimizing these conditions may improve outcomes. Pulmonary rehabilitation (PR) has proven to be a useful management strategy for patients with chronic lung diseases including chronic obstructive pulmonary disease, interstitial lung disease and pulmonary hypertension. (Source: R...
Source: Respiratory Medicine CME - January 22, 2015 Category: Respiratory Medicine Authors: Hiram Rivas-Perez, Patrick Nana-Sinkam Tags: Review Source Type: research

Costs and health-related quality of life of patients with cystic fibrosis and their carers in France
Our goal was to provide data on the economic burden and health-related quality of life (HRQoL) associated with cystic fibrosis (CF) in France. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - January 22, 2015 Category: Respiratory Medicine Authors: Karine Chevreul, Karen Berg Brigham, Morgane Michel, Gilles Rault, BURQOL-RD Research Network Tags: Original Article Source Type: research

Pollution control up in the air
Publication date: Available online 22 January 2015 Source:The Lancet Respiratory Medicine Author(s): The Lancet Respiratory Medicine (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial
Publication date: Available online 21 January 2015 Source:The Lancet Respiratory Medicine Author(s): Amy H Y Chan , Alistair W Stewart , Jeff Harrison , Carlos A Camargo Jr , Peter N Black , Edwin A Mitchell Background Suboptimum adherence to preventive asthma treatment is associated with substantial morbidity and mortality, yet adherence often remains poor. We aimed to investigate whether use of an inhaler with audiovisual reminders leads to improved adherence and asthma outcomes in school-aged children who presented to the emergency department with an asthma exacerbation. Methods We did a randomised controlled trial i...
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

Monitoring and adherence in asthma management
Publication date: Available online 21 January 2015 Source:The Lancet Respiratory Medicine Author(s): Stanley J Szefler (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - January 22, 2015 Category: Respiratory Medicine Source Type: research

Incidence and severity of childhood pneumonia in the first year of life in a South African birth cohort: the Drakenstein Child Health Study
Publication date: February 2015 Source:The Lancet Global Health, Volume 3, Issue 2 Author(s): David M le Roux , Landon Myer , Mark P Nicol , Heather J Zar Background Childhood pneumonia causes substantial mortality and morbidity. Accurate measurements of pneumonia incidence are scarce in low-income and middle-income countries, particularly after implementation of pneumococcal conjugate vaccine. We aimed to assess the incidence, severity, and risk factors for pneumonia in the first year of life in children enrolled in a South African birth cohort. Methods This birth cohort study is being done at two sites in Paarl, a per...
Source: The Lancet Global Health - January 22, 2015 Category: Global & Universal Source Type: research

Comparative Effectiveness of Three Anxiolytics for Acute Respiratory Infections: Antibiotics, C-Reactive Protein Point-of-Care Testing, and Improved Communication
(Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - January 22, 2015 Category: Internal Medicine Source Type: research

Extracorporeal life support as bridge to lung transplantation: a systematic review
Conclusions: In most of the studies, patients on ECMO while awaiting lung transplantation also received invasive mechanical ventilation. Therefore, whether ECMO as an alternative, rather than an adjunction, to invasive mechanical ventilation is a better bridging strategy to lung transplantation still remains an unresolved issue. ECMO support as a bridge for these patients could provide acceptable one-year survival. Future studies are needed to investigate ECMO as part of an algorithm of care for patients with end-stage lung disease. (Source: Critical Care)
Source: Critical Care - January 22, 2015 Category: Intensive Care Authors: Davide ChiumelloSilvia CoppolaSara FroioAndrea ColomboLorenzo Del Sorbo Source Type: research

Overview of Disinfection By-products and Associated Health Effects
Abstract The presence of chemical compounds formed as disinfection by-products (DBPs) is widespread in developed countries, and virtually whole populations are exposed to these chemicals through ingestion, inhalation, or dermal absorption from drinking water and swimming pools. Epidemiological evidence has shown a consistent association between long-term exposure to trihalomethanes and the risk of bladder cancer, although the causal nature of the association is not conclusive. Evidence concerning other cancer sites is insufficient or mixed. Numerous studies have evaluated reproductive implications, including sperm...
Source: Current Environmental Health Reports - January 22, 2015 Category: Environmental Health Source Type: research

IJERPH, Vol. 12, Pages 1135-1155: Nuclear and Mitochondrial DNA Alterations in Newborns with Prenatal Exposure to Cigarette Smoke
Newborns exposed to maternal cigarette smoke (CS) in utero have an increased risk of developing chronic diseases, cancer, and acquiring decreased cognitive function in adulthood. Although the literature reports many deleterious effects associated with maternal cigarette smoking on the fetus, the molecular alterations and mechanisms of action are not yet clear. Smoking may act directly on nuclear DNA by inducing mutations or epigenetic modifications. Recent studies also indicate that smoking may act on mitochondrial DNA by inducing a change in the number of copies to make up for the damage caused by smoking on the respirato...
Source: International Journal of Environmental Research and Public Health - January 22, 2015 Category: Environmental Health Authors: Francesca PiriniElisa GuidaFahcina LawsonAndrea MancinelliRafael Guerrero-Preston Tags: Review Source Type: research

Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia
In conclusion, steatotic livers exhibited apparent mitochondrial dysfunction through an alteration in C‐I activity, and this made them more susceptible to prolonged cold ischemia. The clinically based IPC protocol used here restored MF in cases of mild hepatic steatosis by attenuating C‐I–mediated leaks after prolonged cold ischemia, but it did work not in livers with moderate or severe steatosis. Liver Transpl, 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - January 22, 2015 Category: Transplant Surgery Authors: Michael J. J. Chu, Anthony J. R. Hickey, Yannan Jiang, Amorita Petzer, Adam S. J. R. Bartlett, Anthony R. J. Phillips Tags: Original Article Source Type: research

Update on Fungal Respiratory Disease in Horses
This article summarizes the available literature regarding the cause, diagnosis, and treatment of equine fungal respiratory disease. (Source: Veterinary Clinics of North America: Equine Practice)
Source: Veterinary Clinics of North America: Equine Practice - January 22, 2015 Category: Veterinary Research Authors: Allison J. Stewart, Rosemary S. Cuming Source Type: research

The Relationship Between the Mechanisms of Action and Safety Profiles of Intrathecal Morphine and Ziconotide: A Review of the Literature
ConclusionsIT morphine and IT ziconotide are approved by the US Food and Drug Administration for patients who do not respond to less invasive treatments, but the safety profiles of each may make them more or less appropriate for certain patient populations. (Source: Pain Medicine)
Source: Pain Medicine - January 22, 2015 Category: Anesthesiology Authors: Lynn R. Webster Tags: Review Source Type: research

Palatal surface and volume in mouth-breathing subjects evaluated with three-dimensional analysis of digital dental casts--a controlled study
Conclusions: Subjects with prolonged mouth breathing showed a significant reduction of the palatal surface area and volume leading to a different development of the palatal morphology when compared with subjects with normal breathing pattern. (Source: The European Journal of Orthodontics)
Source: The European Journal of Orthodontics - January 22, 2015 Category: Dentistry Authors: Lione, R., Franchi, L., Huanca Ghislanzoni, L. T., Primozic, J., Buongiorno, M., Cozza, P. Tags: Original Article Source Type: research

The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma
To examine the effect of the quadrivalent human papillomavirus vaccine, Gardasil, on the disease course of patients with recurrent respiratory papillomatosis (RRP). (Source: Journal of Voice)
Source: Journal of Voice - January 22, 2015 Category: ENT & OMF Authors: David L. Young, Michael W. Moore, Lucinda Ann Halstead Source Type: research

Aerodynamic Measures and Biofeedback as Management in Persistent Paradoxical Vocal Fold Motion and Reverse Phonation
We present an unusual case of persistent reverse phonation secondary to respiratory distress associated with PVFM. (Source: Journal of Voice)
Source: Journal of Voice - January 22, 2015 Category: ENT & OMF Authors: Linda M. Carroll, Melin Tan Source Type: research

Asthma-COPD Overlap: Clinical Relevance of Genomic Signatures of Type 2 Inflammation in COPD.
Conclusion: These data identify airway gene expression alterations that can co-occur in asthma and COPD. The association of the Th2 signature with increased severity and "asthma-like" features (including a favorable corticosteroid response) in COPD suggests Th2 inflammation is important in a COPD subset that cannot be identified by clinical history of asthma. PMID: 25611785 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - January 22, 2015 Category: Respiratory Medicine Authors: Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenberg ME, Spira A, Woodruff PG Tags: Am J Respir Crit Care Med Source Type: research

Pathologic Regulation of Collagen I by an Aberrant PP2A/HDAC4/miR-29 Signal Axis in IPF Fibroblasts.
Abstract Idiopathic Pulmonary Fibrosis is characterized by the relentless expansion of fibroblasts depositing type I collagen within the alveolar wall and obliterating the alveolar airspace. miR-29 is a potent regulator of collagen expression. In IPF miR-29 levels are low while type I collagen expression is high. However the mechanism for suppression of miR-29 and increased type I collagen expression in IPF remains unclear. Here we show that when IPF fibroblasts are seeded on polymerized type I collagen, miR-29c levels are suppressed and type I collagen expression is high. In contrast, miR-29c is high and type I co...
Source: Am J Respir Cell Mol... - January 22, 2015 Category: Respiratory Medicine Authors: Khalil W, Xia H, Bodempudi V, Kahm J, Hergert P, Smith K, Peterson M, Parker M, Herrera J, Bitterman PB, Henke CA Tags: Am J Respir Cell Mol Biol Source Type: research

Treatment-related Biomarkers in Pulmonary Hypertension.
Abstract Significant advances in the treatment of pulmonary arterial hypertension (PAH) over the last two decades have led to the introduction of multiple classes of oral therapy, but the disease remains devastating for many patients. Disease progression in spite of oral monotherapy is a major problem and alternative therapy, such as infusion of prostacyclins, is cumbersome and carries considerable potential morbidity. There is some evidence to support, and increasing use of, combination oral therapy including drugs from the endothelin receptor antagonist (ERA) and type-5 phosphodiesterase inhibitor (PDE5i) classes...
Source: Am J Respir Cell Mol... - January 22, 2015 Category: Respiratory Medicine Authors: Swaminathan AC, Dusek AC, McMahon TJ Tags: Am J Respir Cell Mol Biol Source Type: research

Differential effect of mMRC dyspnea, CAT and CCQ for symptom evaluation within the new GOLD staging and mortality in COPD.
Conclusions: The CAT and the CCQ have similar ability for predicting all-cause mortality in patients with chronic obstructive pulmonary disease, but were inferior to mMRC dyspnea scores. We suggest new thresholds for CAT and CCQ scores based on mortality risk that could be useful for the new GOLD grading classification. ClinicalTrials.gov Identifier: NCT01122758. PMID: 25612228 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Casanova C, Marin JM, Martinez-Gonzalez C, de Lucas-Ramos P, Mir-Viladrich I, Cosio B, Peces-Barba G, Solanes-García I, Agüero R, Feu-Collado N, Calle-Rubio M, Alfageme I, de Diego-Damia A, Irigaray R, Marín M, Balcells E, Llunell A, Galdiz JB, Golpe R Tags: Chest Source Type: research

Impact of chronic obstructive pulmonary disease in the outcome of intensive care unit-acquired pneumonia with and without previous intubation.
Conclusion: COPD was independently associated with decreased 90-day survival; in patients with VAP but not in those without previous intubation. PMID: 25612147 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - January 22, 2015 Category: Respiratory Medicine Authors: Rinaudo M, Ferrer M, Terraneo S, De Rosa F, Peralta R, Fernández-Barat L, Li Bassi G, Torres A Tags: Chest Source Type: research