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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Changes in Breathing Variables During a 30-Minute Spontaneous Breathing Trial.
CONCLUSIONS: During the course of a 30-min SBT, breathing variables remain relatively constant, and potentially significant changes in these variables after 10 min into the trial are uncommon. These findings should be considered when addressing aspects of duration and supervision of SBTs in weaning protocols. PMID: 25316884 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - October 14, 2014 Category: Respiratory Medicine Authors: Figueroa-Casas JB, Connery SM, Montoya R Tags: Respir Care Source Type: research

Psychroserpens jangbogonensis sp. nov., a psychrophilic bacterium isolated from Antarctic marine sediment.
Abstract A Gram-staining-negative, yellow-pigmented, aerobic, rod-shaped, and non-motile bacterium, PAMC 27130T, was isolated from the marine sediment of the Ross Sea, Antarctica. The temperature, pH, and NaCl tolerance ranges for the growth were 4-20°C, 6.0-9.0, and 0.5-5.0 % (w/v), respectively. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain PAMC 27130T belonged to the genus Psychroserpens and was closely related to Psychroserpens mesophilus, Psychroserpens damuponensis and Psychroserpens burtonensis with 97.2, 94.7 and 94.2 % sequence similarities, respectively. Genomic relatedness an...
Source: International Journal of Systematic and Evolutionary Microbiology - October 14, 2014 Category: Microbiology Authors: Baek K, Lee YM, Hwang CY, Park H, Jung YJ, Kim MK, Hong SG, Kim JH, Lee HK Tags: Int J Syst Evol Microbiol Source Type: research

Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research

Postsurgical behaviors in children with and without symptoms of sleep-disordered breathing
Conclusions Children presenting for surgery with symptoms of SDB have an increased risk for problematic behaviors following surgery. These results are potentially important in questioning whether the observed increase in problematic behaviors is biologically grounded in SDB or simply a response to poor sleep habits/hygiene. (Source: Perioperative Medicine)
Source: Perioperative Medicine - October 14, 2014 Category: Surgery Source Type: research

How to count coughs? Counting by ear, the effect of visual data and the evaluation of an automated cough monitor
Cough causes morbidity and transmits disease yet has been under-researched. The best method for recognising and counting coughs remains unclear. We tested the accuracy of the human ear and measured the influence of visual data on cough counting. We also evaluated PulmoTrack®, a potentially fully-automated cough monitor. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 14, 2014 Category: Respiratory Medicine Authors: Richard D. Turner, Graham H. Bothamley Source Type: research

Efficacy and safety of umeclidinium/vilanterol 62.5/25 mcg and tiotropium 18 mcg in chronic obstructive pulmonary disease: results of a 24-week, randomized, controlled trial
Combinations of inhaled long-acting bronchodilator therapies such as muscarinic antagonists and β2-agonists may be more effective than monotherapy in the treatment of chronic obstructive pulmonary disease (COPD). (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 14, 2014 Category: Respiratory Medicine Authors: M. Reza Maleki-Yazdi, Thomas Kaelin, Nathalie Richard, Michael Zvarich, Alison Church Source Type: research

Cost of multi drug resistance tuberculosis in Germany
4220 new cases of tuberculosis (TB) were reported in Germany in 2012; of those, 65 cases were multidrug-resistant TB (MDR-TB) or extensively multidrug-resistant TB (XDR-TB) cases. However, there is only limited information on the economic consequences of drug resistance patterns on the treatment costs of MDR-and XDR-TB patients. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 14, 2014 Category: Respiratory Medicine Authors: R. Diel, A. Nienhaus, N. Lampenius, S. Rüsch-Gerdes, E. Richter Source Type: research

Semiquantitative cough strength score and associated outcomes in noninvasive positive pressure ventilation patients with acute exacerbation of chronic obstructive pulmonary disease
Weak cough may result in the failure of noninvasive positive pressure ventilation (NPPV) in patients with AECOPD. However, no detailed descriptions have yet been published for the measurement of cough strength and associated outcomes in AECOPD patients. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - October 14, 2014 Category: Respiratory Medicine Authors: Liping Fan, Qinghua Zhao, Yucun Liu, Lintong Zhou, Jun Duan Source Type: research

Metformin and respiratory chain complex I: the last piece of the puzzle?
Abstract Metformin is the most widely prescribed drug used to treat patients affected by Type 2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed to complex I inhibition, but the mechanism by which metformin leads to complex I inhibition is not fully understood. Although it has been reported that the incubation of functionally isolated complex I in the presence of high concentrations of metformin led to its inhibition, much lower concentrations of metformin have been shown to...
Source: The Biochemical Journal - October 13, 2014 Category: Biochemistry Authors: Fontaine E Tags: Biochem J Source Type: research

Urea.
Abstract Urea is generated by the urea cycle enzymes, which are mainly in the liver but are also ubiquitously expressed at low levels in other tissues. The metabolic process is altered in several conditions such as by diets, hormones, and diseases. Urea is then eliminated through fluids, especially urine. Blood urea nitrogen (BUN) has been utilized to evaluate renal function for decades. New roles for urea in the urinary system, circulation system, respiratory system, digestive system, nervous system, etc., were reported lately, which suggests clinical significance of urea. PMID: 25298336 [PubMed - in process]...
Source: Sub-Cellular Biochemistry - October 13, 2014 Category: Biochemistry Authors: Wang H, Ran J, Jiang T Tags: Subcell Biochem Source Type: research

Increased CD8 T‐cell granzyme B in COPD is suppressed by treatment with low‐dose azithromycin
ConclusionsWe provide further evidence for the application of low‐dose azithromycin as an attractive adjunct treatment option for controlling epithelial cell apoptosis, abnormal airway repair and chronic inflammation in COPD. (Source: Respirology)
Source: Respirology - October 13, 2014 Category: Respiratory Medicine Authors: Sandra Hodge, Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N. Reynolds Tags: Original Article Source Type: research

Partial palivizumab prophylaxis and increased risk of hospitalization due to respiratory syncytial virus in a medicaid population: a retrospective cohort analysis
Conclusions: RSV-related hospitalization rates were significantly higher in high-risk Medicaid infants with partial palivizumab prophylaxis compared with fully prophylaxed infants. These findings suggest that reduced and/or delayed dosing is less effective. (Source: BMC Pediatrics)
Source: BMC Pediatrics - October 13, 2014 Category: Pediatrics Authors: Leonard KrilovAnthony MasaquelLeonard WeinerDavid SmithSally WadeParthiv Mahadevia Source Type: research

Histone Deacetylase inhibitor regulates the balance of Th17/Treg in allergic asthma
ConclusionThe histone deacetylase inhibitor TSA can regulate the balance of Th17/Treg in asthma by regulating the activity of histone deacetylase. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Xiaoxia Hou, Huanying Wan, Xiangyan Ai, Yuheng Shi, Yingmeng Ni, Wei Tang, Guochao Shi Tags: Original Article Source Type: research

Safety of interventional bronchoscopy through complication review at a cancer center
ConclusionThe complication rate with regards to bronchoscopy is comparable to historical controls according to the related literature, and their occurrence appears to be sporadic, not relevant to patient characteristics and mostly related to the bronchoscopy itself rather than the introduction of new techniques. Bronchoscopy remains safe along with technical innovations. However, risk recognition and effective prevention is essential. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Li‐Han Hsu, Chia‐Chuan Liu, Jen‐Sheng Ko, Chao‐Chun Chen, An‐Chen Feng Tags: Original Article Source Type: research

Autoimmune Symptoms in Idiopathic Pulmonary Fibrosis: Clinical Significance
ConclusionsIt appears that autoimmune symptoms are associated with better prognosis among IPF patients. However, future studies are needed to validate our findings. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Esam H. Alhamad, Joseph G. Cal, Ahmad A. AlBoukai, Shaffi A. Shaik, Mohammed A Omair Tags: Original Article Source Type: research

Comparison of Pressure‐ and Volume‐Controlled Ventilation in Laparoscopic Cholecystectomy Operations
ConclusionIn this study, with volume‐controlled ventilation anesthesia in laparoscopic cholecystectomy, higher tidal volume and lower alveolar‐arterial oxygen gradient were achieved after pneumoperitoneum. These findings indicated that VCV mode can provide a better alveolar ventilation than PCV mode in laparoscopic cholecystectomy operations. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Venera Aydın, Hanife Karakaya Kabukcu, Nursel Sahin, Ayhan Mesci, Ayse Gulbin Arici, Gulsum Kahveci, Ozgen Ozmete Tags: Original Article Source Type: research

A meta‐analysis: Is low‐dose computed tomography a superior method for risky lung cancers screening population?
ConclusionAmong the risky population, LDCT screening find out more stage I lung cancers and total lung cancers, compared with Chest X‐ray or no screening, and also shows advantages in decreasing lung cancer‐specific mortality, but the screening method does not decrease all cause mortality and have a higher false‐positive rates in diagnosis. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Cuiping Fu, Zilong Liu, Fen Zhu, Shanqun Li, Liyan Jiang Tags: Other Source Type: research

Cytokine response to the 6‐minute walk test in individuals with different degrees of COPD
ConclusionAfter the 6MWT, a discrete inflammatory response was observed in COPD patients, independent of the degree of severity. The results concerning IL‐4 and IL‐6 levels can be indicative of an attempt to control inflammation after the 6MWT in COPD patients. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Gilson Pires Dorneles, Priscila Vianna, Diego Del Duca Lima, Lucas Galant, Alexandre Simões Dias, José Artur Bogo Chies, Mariane Borba Monteiro, Alessandra Peres Tags: Original Article Source Type: research

A rare case of multinodular pulmonary amyloidosis
We present an unusual case of primary pulmonary multinodular amyloidosis in a middle‐aged woman. She presented our hospital with cough and chest distress only. Results of CT showed multiple nodules with diffused calcification and thick‐walled cavity in bilateral lung parenchyma. It is difficult to distinguish parenchymal nodular amyloidosis from malignant primary lung neoplasm in radiology because of their similar images. Thus, the role of CT‐guided core needle biopsy in diagnosis of pulmonary mutinodular amyloidosis is very important. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Jizhen Feng, Jiamei Li, Chunxiang Ling, Qingwei Liu Tags: Other Source Type: research

Sertraline Hydrochloride Treatment for Patients with Stable Chronic Obstructive Pulmonary Disease Complicated with Depression: A Randomized Controlled Trial
ConclusionsAntidepressant treatment can improve the quality of life and exercise capacity of patients with depression, and it can also improve depression scores, but not lung function. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Yuanqiang He, Yulong Zheng, Chuanqin Xu, Haichen Yang, Ziyu Wang, LiYang Zhou, Yufeng Wan, Donghui Zheng, Jing Zhu Tags: Original Article Source Type: research

Association between genetic polymorphisms in XPD and XRCC1 genes and risks of non‐small‐cell lung cancer in East Chinese Han population
ConclusionsThe results suggested that genetic polymorphisms in XPD‐751, XRCC1‐194, and XRCC1‐399 were related to the risk of non‐small cell lung cancer, among which XPD‐751SNP was responsible for adenocarcinoma, while XRCC1‐194SNP was closely linked to squamous carcinoma. Smoking and XRCC1‐194SNP were risk factors of non‐small cell lung cancer. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Yong Du, Yanchao He, Zhoufang Mei, Ling Qian, Jindong Shi, Zhijun Jie Tags: Original Article Source Type: research

Delays for diagnosis and treatment of lung cancers: a systematic review
Abstract The impact of diagnosis and treatment delays for non‐small cell lung cancer (NSCLC) management is poorly understood, even if the literature on the subject is currently increasing in importance. We have few indicators which can serve as reference for quality assurance actions. Several studies analyzed these delays mostly in a monocentric setting. There is an important variability in the definition of these delays, in the collection methods, and in the results obtained. However, it seems distinctly clear that long delays are frequently observed in less symptomatic patients and, therefore, are accompanied by better...
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Vinas F, Ben Hassine I, Jabot L, Monnet I, Chouaid C Tags: Review Article Source Type: research

Adherence to the Global Initiative for Chronic Obstructive Lung Disease guidelines for management of COPD: A hospital‐ base study
ConclusionThe level of adherence to GOLD guidelines for the management of COPD exacerbation was suboptimal at our teaching hospital. Further improvements in adherence to these guidelines are needed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Seyed Masoom Masoompour, Abbas Mohamadi, Hamideh Mahdaviazad Tags: Original Article Source Type: research

Fiducial marker placement via conventional or electromagnetic navigation bronchoscopy (ENB): An interdisciplinary approach to the curative management of lung cancer
ConclusionFiducial marker placement may be an interesting bronchoscopic technique in the interdisciplinary therapeutic approach to inoperable early stage lung cancer. In the described cases therapy planning was successful and no procedure‐related complications were observed. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - October 13, 2014 Category: Respiratory Medicine Authors: Lars Hagmeyer, Christina Priegnitz, Martin Kocher, Burkhart Schilcher, Wilfried Budach, Marcel Treml, Sven Stieglitz, Winfried Randerath Tags: Original Article Source Type: research

Mitochondrial dysfunction in rat steatotic liver is due to a defect in Complex‐I making them more susceptible to prolonged cold ischemia
Conclusion: Steatotic livers exhibited an apparent mitochondrial dysfunction through an alteration in C‐I activity, making them more susceptible to prolonged cold ischemia. The clinical‐based IPC protocol used here restored MF in mild hepatic steatosis by attenuating C‐I mediated leak following prolonged cold ischemia but not in livers with moderate or severe steatosis. Liver Transpl , 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - October 13, 2014 Category: Transplant Surgery Authors: Michael J.J. Chu, Anthony J.R. Hickey, Yannan Jiang, Amorita Petzer, Adam S.J.R. Bartlett, Anthony R.J. Phillips Tags: Original Article Source Type: research

Evidence-based guideline summary: Diagnosis and treatment of limb-girdle and distal dystrophies: Report of the Guideline Development Subcommittee of the American Academy of Neurology and the Practice Issues Review Panel of the American Association of Neuromuscular & Electrodiagnostic Medicine
Objective: To review the current evidence and make practice recommendations regarding the diagnosis and treatment of limb-girdle muscular dystrophies (LGMDs). Methods: Systematic review and practice recommendation development using the American Academy of Neurology guideline development process. Results: Most LGMDs are rare, with estimated prevalences ranging from 0.07 per 100,000 to 0.43 per 100,000. The frequency of some muscular dystrophies varies based on the ethnic background of the population studied. Some LGMD subtypes have distinguishing features, including pattern of muscle involvement, cardiac abnormalities, ex...
Source: Neurology - October 13, 2014 Category: Neurology Authors: Narayanaswami, P., Weiss, M., Selcen, D., David, W., Raynor, E., Carter, G., Wicklund, M., Barohn, R. J., Ensrud, E., Griggs, R. C., Gronseth, G., Amato, A. A. Tags: All Neuromuscular Disease, Developmental disorders, All Rehabilitation, All Genetics SPECIAL ARTICLE Source Type: research

Highlights from this issue
A spring in your lung Bronchoscopic lung volume reduction is very much a hot topic. Hitherto coils have been positioned for contraceptive purposes somewhat distal to the lungs; so are the Gynaecologists making a Putin-like bid for our territory? This month we publish 12-month outcomes after bronchoscopic insertion of a nitinol coil device in patients with emphysema (Hot topic; see page 980). Coils have potential advantages over other techniques as their spring like effect might address loss of elasticity (is there a whole body coil for your editors?) and dynamic airway collapse; they are applicable in the 60% of patients w...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Bush, A., Pavord, I. Tags: Airwaves Source Type: research

Emphysema: time to say farewell to therapeutic nihilism
It is an interesting time for the management of emphysema. In this condition, destruction of lung parenchyma associated with reduced elastic recoil and dynamic airways closure produce gas trapping and increased operating lung volumes, leading to breathlessness and exercise limitation. It has historically been defined as an irreversible process, which has led to a degree of therapeutic nihilism. One manifestation of this has been the curious neglect of lung volume reduction surgery (LVRS). Clinical guidelines,1 reflecting trial evidence,2 recommend consideration of LVRS in selected patients with upper lobe predominant emphy...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Zoumot, Z., Jordan, S., Hopkinson, N. S. Tags: Open access Editorial Source Type: research

The child is father of the man: the importance of early life influences on lung development
There is a great deal of interest in the early life determinants of lung function as possible determinants of obstructive airways disease through the rest of the life course. Failure to attain maximal lung function in early adult life either alone or coupled with accelerated decline during adulthood could contribute to the substantial burden of morbidity and mortality associated with obstructive airway disease and COPD in later life.1 Longitudinal studies of lung function in unselected populations have suggested that decrements of FEV1 established in the first few years after birth track to adulthood,2 thus pointing to ear...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Henderson, A. J. Tags: Editorial Source Type: research

Antioxidants and respiratory disease: the uric acid paradox
For humble individuals like myself, there is one poor comfort, which is this, viz. that gout, unlike any other disease, kills more rich men than poor, more wise men than simple. Thomas Sydenham. In clinical practice, high blood concentrations of uric acid (UA) are generally thought to be a bad thing—primarily because of the risk of gout, but also because individuals with high UA concentrations are at increased risk of cardiovascular disease, metabolic syndrome and hypertension1; these associations may reflect the fact that, under certain circumstances, UA can be pro-oxidant.2 Perhaps less appreciated are the potentia...
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Shaheen, S. O. Tags: Editorial Source Type: research

Lung volume reduction coil treatment for patients with severe emphysema: a European multicentre trial
Conclusions LVR coil treatment results in significant clinical improvements in patients with severe emphysema, with a good safety profile and sustained results for up to 1 year. Trial registration number: NCT01328899. (Source: Thorax)
Source: Thorax - October 13, 2014 Category: Respiratory Medicine Authors: Deslee, G., Klooster, K., Hetzel, M., Stanzel, F., Kessler, R., Marquette, C.-H., Witt, C., Blaas, S., Gesierich, W., Herth, F. J. F., Hetzel, J., van Rikxoort, E. M., Slebos, D.-J. Tags: Hemoptysis, Open access, Pneumonia (infectious disease), TB and other respiratory infections, Pneumonia (respiratory medicine), Cardiothoracic surgery Chronic obstructive pulmonary disease Source Type: research