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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Breathing life into dinosaurs: tackling challenges of soft-tissue restoration and nasal airflow in extinct species.
Abstract The nasal region plays a key role in sensory, thermal, and respiratory physiology, but exploring its evolution is hampered by a lack of preservation of soft-tissue structures in extinct vertebrates. As a test case, we investigated members of the "bony-headed" ornithischian dinosaur clade Pachycephalosauridae (particularly Stegoceras validum) because of their small body size (which mitigated allometric concerns) and their tendency to preserve nasal soft tissues within their hypermineralized skulls. Hypermineralization directly preserved portions of the olfactory turbinates along with an internal nasal ridge...
Source: Anatomical Record - October 19, 2014 Category: Anatomy Authors: Bourke JM, Porter WR, Ridgely RC, Lyson TR, Schachner ER, Bell PR, Witmer LM Tags: Anat Rec (Hoboken) Source Type: research

Alcohol mediates inhibition of organic dust-stimulated airway epithelial cell TNF alpha through nitric oxide and PKC mediated inhibition of ADAM17
Studies show that farm workers in rural areas consume more alcohol than those who reside in urban areas. The airways are continuously exposed to various pollutants on a daily basis. Occupational exposures such as agricultural work can pose hazards on the respiratory system. The dust that accumulates in swine confinement facilities can cause adverse respiratory effects. We have established that hog barn dust induces inflammation in the airway including the release of proinflammatory cytokines such as tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6) and interleukin-8 (IL-8). (Source: Alcohol)
Source: Alcohol - October 19, 2014 Category: Addiction Authors: C.L. Gerald, D.J. Romberger, J.M. DeVasure, A.J. Heires, J.H. Sisson, T.A. Wyatt Source Type: research

Alveolar macrophage production of inflammatory mediators in subjects with alcohol use disorders
We examined the effect of AUDs on profiles of inflammatory cytokines, chemokines, and growth factors in human AMs obtained from bronchoalveolar lavage (BAL) samples. (Source: Alcohol)
Source: Alcohol - October 19, 2014 Category: Addiction Authors: E.B. O’Halloran, M.M. Chen, E.J. Kovacs, E.L. Burnham Source Type: research

Pioglitazone attenuates alcohol-induced alveolar macrophage oxidative stress and dysfunction by up-regulating microRNA-92a/b
Alcohol abuse increases risk of respiratory infections through impaired lung immunity mediated by enhanced oxidative stress and alveolar macrophage (AM) phagocytic dysfunction. PPARγ ligands reduce lung oxidative stress through down-regulation of NADPH oxidase 4 (Nox4) and transforming growth factor beta-1 (TGFβ1). We hypothesized that treatment with pioglitazone (PIO), a PPARγ ligand, would attenuate alcohol-induced AM dysfunction by up-regulating microRNA (miR)-92a/b, which target Nox4 and TGFβ1, and subsequently decrease AM oxidative stress. (Source: Alcohol)
Source: Alcohol - October 19, 2014 Category: Addiction Authors: S.M. Yeligar, F.L. Harris, L.A.S. Brown, C.M. Hart Source Type: research

Elective Decompression of the Left Ventricle in Pediatric Patients May Reduce the Duration of Venoarterial Extracorporeal Membrane Oxygenation
Abstract We aimed to determine the effect of elective left heart decompression at the time of initiation of central venoarterial extracorporeal membrane oxygenation (VA ECMO) on VA ECMO duration and clinical outcomes in children in a single tertiary ECMO referral center with a large pediatric population from a national referral center for pediatric cardiac surgery. We studied 51 episodes of VA ECMO in a historical cohort of 49 pediatric patients treated between the years 1990 and 2013 in the Paediatric Intensive Care Unit (PICU) of the Royal Children's Hospital, Melbourne. The cases had a variety of diagnoses including con...
Source: Artificial Organs - October 19, 2014 Category: Transplant Surgery Authors: Douglas F. Hacking, Derek Best, Yves d'Udekem, Christian P. Brizard, Igor E. Konstantinov, Johnny Millar, Warwick Butt Tags: Main Text Article Source Type: research

Non-pharmaceutical management of respiratory morbidity in children with severe global developmental delay.
CONCLUSIONS: This review found no high-quality evidence for any single intervention for the management of respiratory morbidity in children with severe global developmental delay. Our search yielded data on a wide range of interventions of interest. Significant differences in study design and in outcome measures precluded the possibility of meta-analysis. No conclusions on efficacy or safety of interventions for respiratory morbidity in children with severe global developmental delay can be made based upon the findings of this review.A co-ordinated approach to future research is vital to ensure that high-quality evidence b...
Source: Cochrane Database of Systematic Reviews - October 19, 2014 Category: Journals (General) Authors: Winfield NR, Barker NJ, Turner ER, Quin GL Tags: Cochrane Database Syst Rev Source Type: research

Orbital cellulitis in Scotland: current incidence, aetiology, management and outcomes
This study was a 1-year prospective observational study using the Scottish Ophthalmic Surveillance Unit reporting system among Scottish ophthalmologists. Results The response rate from ophthalmologists was 66.4%. There were 15 children and 5 adults reported giving an incidence of 1.6 per 100 000 and 0.1 per 100 000 in children and adults, respectively. 47% of children had a preceding upper respiratory tract infection with 87% having radiological evidence of sinus disease. Within the adult group, there was preceding immunosuppression and trauma. Streptococcus (66%) and Haemophilus (46%) species were the most comm...
Source: British Journal of Ophthalmology - October 19, 2014 Category: Opthalmology Authors: Murphy, C., Livingstone, I., Foot, B., Murgatroyd, H., MacEwen, C. J. Tags: Paediatrics, Epidemiology Original articles - Clinical science Source Type: research

Effect of concurrent oxygen therapy on accuracy of forecasting imminent postoperative desaturation
In conclusion, we report the use of autoregressive models to predict \({\hbox {SpO}}_2\)  and forecast imminent critical desaturation events in the postoperative period with high degree of accuracy. These models reliably predict critical desaturation in patients receiving supplemental oxygen therapy. While high-fidelity prophylactic interventions that could modify these inciting events are in development, our current study offers proof of concept that the afferent limb of such a system can be modeled with a high degree of accuracy. (Source: Journal of Clinical Monitoring and Computing)
Source: Journal of Clinical Monitoring and Computing - October 19, 2014 Category: Information Technology Source Type: research

Middle East respiratory syndrome coronavirus (MERS-CoV): Prevention in travelers
Middle East respiratory syndrome coronavirus (MERS-CoV), a novel coronavirus that causes a severe lower respiratory tract infection in humans, emerged in the Middle East in 2012. Since then, MERS-CoV has caused an ongoing epidemic in the Arabian Peninsula with sporadic cases imported in Europe, North Africa, Southeast Asia, and the United States of America. As of 28th May 2014, 636 laboratory-confirmed cases of infection with MERS-CoV have been reported to World Health Organization including 14 cases imported by travelers. (Source: Travel Medicine and Infectious Disease)
Source: Travel Medicine and Infectious Disease - October 19, 2014 Category: Infectious Diseases Authors: Androula Pavli, Sotirios Tsiodras, Helena C. Maltezou Tags: Review Source Type: research

Pulmonary arterial hypertension-related myopathy: An overview of current data and future perspectives
Exercise intolerance is one of the key features of pulmonary arterial hypertension (PAH). Main determinants of exercise impairment include hypoxemia, reduced right ventricular output, perfusion/ventilation mismatch and weakness of skeletal and breathing muscles. Aim of the current review is to describe the findings in existing literature about respiratory and muscle dysfunction in PAH. Animal and clinical studies regarding both respiratory and peripheral skeletal muscles and the effect of exercise training on muscle function in PAH patients are analyzed. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - October 19, 2014 Category: Nutrition Authors: A.M. Marra, M. Arcopinto, E. Bossone, N. Ehlken, A. Cittadini, E. Grünig Tags: Review Source Type: research

Future target-based drug discovery for tuberculosis?
New drugs that retain potency against multidrug/extensively drug-resistant strains of Mycobacterium tuberculosis, with the additional benefit of a shortened treatment duration and ease of administration, are urgently needed by tuberculosis (TB) control programs. Efforts to develop this new generation of treatment interventions have been plagued with numerous problems, the most significant being our insufficient understanding of mycobacterial metabolism during disease. This, combined with limited chemical diversity and poor entry of small molecules into the cell, has limited the number of new bioactive agents that result fr...
Source: Tuberculosis - October 19, 2014 Category: Respiratory Medicine Authors: Bavesh Davandra Kana, Petros C. Karakousis, Tanya Parish, Thomas Dick Source Type: research

Consumption of unprocessed cow's milk protects infants from common respiratory infections
Breast-feeding is protective against respiratory infections in early life. Given the co-evolutionary adaptations of humans and cattle, bovine milk might exert similar anti-infective effects in human infants. (Source: Journal of Allergy and Clinical Immunology)
Source: Journal of Allergy and Clinical Immunology - October 19, 2014 Category: Allergy & Immunology Authors: Georg Loss, Martin Depner, Laurien H. Ulfman, R.J. Joost van Neerven, Alexander J. Hose, Jon Genuneit, Anne M. Karvonen, Anne Hyvärinen, Vincent Kaulek, Caroline Roduit, Juliane Weber, Roger Lauener, Petra Ina Pfefferle, Juha Pekkanen, Outi Vaarala, Jean Source Type: research

Pulmonary Dysfunction after Lung Transplantation: The Dilemma of Coexisting Mitral Regurgitation
Progression of mitral regurgitation (MR) after lung transplantation previously has been found in patients who were unable to be weaned from mechanical ventilation postoperatively, 1,2 In these patients, surgical repair of the mitral valve (MV) led to successful respiratory recovery. The authors report an unusual case of a patient who underwent left single orthotopic lung transplant (SOLT) and postoperative pulmonary compromise. The possible contribution of coexisting MR was a confounding clinical factor that was addressed successfully upon presentation for subsequent right SOLT. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - October 19, 2014 Category: Anesthesiology Authors: Sharon L. McCartney, Brian J. Colin, R. Duane Davis, J. Mauricio Del Rio, Madhav Swaminathan Tags: E-Challenges & Clinical Decisions Source Type: research

A Five Year Retrospective Study of Short Term Respiratory Support Outcomes For Infants Who Received Tracheostomy Before One Year of Age
This study aims to describe respiratory support requirements at the time of hospital discharge for infants who undergo tracheostomy, and to determine whether certain indications for tracheostomy are significantly associated with ventilator or oxygen dependence at the time of discharge. (Source: International Journal of Pediatric Otorhinolaryngology)
Source: International Journal of Pediatric Otorhinolaryngology - October 19, 2014 Category: ENT & OMF Authors: Elizabeth Cottrill, Janet Lioy, Summer Elshenawy, Jaclyn Rosenzweig, Edward Hopkins, John Chuo, Steven Sobol, Sara DeMauro Source Type: research

Motion management within two respiratory-gating windows: feasibility study of dual quasi-breath-hold technique in gated medical procedures.
In this study, the DQBH biofeedback system utilized the abdominal position obtained using an real-time position management (RPM) system (Varian Medical Systems, Palo Alto, USA) to audio-visually guide a human subject for 4 s breath-hold at EOI and 90% EOE (EOE90%) to improve delivery efficiency. We investigated the residual respiratory motion and the delivery efficiency (duty-cycle) of abdominal displacement within the gating window. The improvement of the abdominal motion reproducibility was evaluated in terms of cycle-to-cycle displacement variability, respiratory period and baseline drift. The DQBH biofeedback system ...
Source: Physics in Medicine and Biology - October 18, 2014 Category: Physics Authors: Kim T, Kim S, Park YK, Youn KK, Keall P, Lee R Tags: Phys Med Biol Source Type: research

[Comment] Offline: 2015—the year to rebuild WHO
The best book about severe acute respiratory syndrome (SARS) was written, not by an expert in infectious diseases, but by a lawyer. David Fidler's SARS, Governance, and the Globalization of Disease (Palgrave, 2004) deserves to be pulled from its dusty shelf and read with intense care. By the standards of most infectious epidemics—tuberculosis, malaria, or HIV, for example—SARS now seems worthy of only a short footnote in global health history: 8422 cases and 916 deaths between November, 2002, and August, 2003. (Source: LANCET)
Source: LANCET - October 18, 2014 Category: Journals (General) Authors: Richard Horton Tags: Comment Source Type: research

[Series] Postinjury abdominal compartment syndrome: from recognition to prevention
Postinjury abdominal compartment syndrome (ACS) is an example of a deadly clinical occurrence that was eliminated by strategic research and focused preventions. In the 1990s, the syndrome emerged with the widespread use of damage control surgery and aggressive crystalloid-based resuscitation. Patients who previously exsanguinated on the operating made it to intensive care units, but then developed highly lethal hyperacute respiratory, renal, and cardiac failure due to increased abdominal pressure. (Source: LANCET)
Source: LANCET - October 18, 2014 Category: Journals (General) Authors: Zsolt J Balogh, William Lumsdaine, Ernest E Moore, Frederick A Moore Tags: Series Source Type: research

Transcutaneous electromyography of the diaphragm: A cardio‐respiratory monitor for preterm infants
ConclusionThis study shows that monitoring RR and HR with transcutaneous dEMG is feasible and repeatable in preterm infants. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - October 18, 2014 Category: Respiratory Medicine Authors: Juliette V. Kraaijenga, Gerard J. Hutten, Frans H. de Jongh, Anton H. van Kaam Tags: Original Article Source Type: research

Fractional exhaled nitric oxide‐guided algorithm for children with asthma
Summary Fractional exhaled nitric oxide (FeNO) is a surrogate marker of eosinophilic airway inflammation in asthma. The randomized controlled parallel study published by Peirsman et al combined GINA guidelines and FeNO level in guiding drug treatment in children with mild to severe asthma. Their target was to control the FeNO level below 20 ppb. The FeNO group resulted in increasing the dosage of inhaled corticosteroid and the usage of leukotriene receptor antagonist. However, the study was not truly randomized and drug adherence was not reported. The FeNO‐guided algorithm failed to improve the primary outcome, the sym...
Source: Pediatric Pulmonology - October 18, 2014 Category: Respiratory Medicine Authors: Qun Ui Lee Tags: Letter to the Editor Source Type: research

Does the 2013 GOLD classification improve the ability to predict lung function decline, exacerbations and mortality: a post-hoc analysis of the 4-year UPLIFT trial
Conclusions: The new classification system is a modest step towards a phenotype approach. It is probably an improvement for the prediction of exacerbations, but a deterioration for predicting mortality and lung function decline.Trial registration: ClinicalTrials.gov NCT00144339 (September 2, 2005). (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 18, 2014 Category: Respiratory Medicine Authors: Lucas GoossensInge LeimerNorbert MetzdorfKarin BeckerMaureen Mölken Source Type: research

Genetic polymorphisms and risk of recurrent wheezing in pediatric age
Conclusions: This study shows a clear relationship between the risk of wheezing and polymorphisms of some genes involved in the immune response. Although further studies are needed to confirm the results, these findings may be useful for the early identification of children at the highest risk of developing recurrent episodes and possibly subsequent asthma. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 18, 2014 Category: Respiratory Medicine Authors: Susanna EspositoValentina IerardiCristina DalenoAlessia ScalaLeonardo TerranovaClaudia TagliabueWalter Peves RiosClaudio PelucchiNicola Principi Source Type: research

Severe Respiratory Illness Associated with Enterovirus D68—Missouri and Illinois, 2014
This report details an increase in cases of enterovirus D68, a cause of severe respiratory illness most commonly found in children, and one that should be considered as potentially problematic in donors or recipients. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - October 18, 2014 Category: Transplant Surgery Tags: Reports From the CDC: MMWR Source Type: research

Development and validation of a prediction model for diagnosing blood stream infections in febrile, non‐neutropenic children with cancer
ConclusionsWe developed a diagnostic prediction model for BSI in febrile pediatric oncology patients without severe neutropenia. External validation is warranted before use in clinical practice. Pediatr Blood Cancer 2014;9999:1–7© 2014 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - October 18, 2014 Category: Cancer & Oncology Authors: Adam J. Esbenshade, M. Cecilia Di Pentima, Zhiguo Zhao, Ayumi Shintani, Jennifer C. Esbenshade, Monique E. Simpson, Kathleen C. Montgomery, Robert B. Lindell, Haerin Lee, Ato Wallace, Kelly L. Garcia, Karel G.M. Moons, Debra L. Friedman Tags: Research Article Source Type: research

Mode of delivery and other risk factors for Escherichia coli infections in very low birth weight infants
Background: Infections in newborns remain one of the most significant problems in modern medicine. Escherichia coli is an important cause of neonatal bloodstream and respiratory tract infections and is associated with high mortality. The aim of our study was to investigate the epidemiology of E. coli infection in Polish neonatal intensive care units (NICUs) and resistance to antibiotics, with particular reference to the safety of very low birth weight infants. Methods: Continuous prospective infection surveillance was conducted in 2009-2012 in five NICUs, including 1,768 newborns whose birth weight was (Source: BMC Pediatrics)
Source: BMC Pediatrics - October 18, 2014 Category: Pediatrics Authors: Agnieszka ChmielarczykJadwiga Wójkowska-MachDorota RomaniszynPawe¿ AdamskiEwa HelwichRyszard LauterbachMonika PobiegaMaria Borszewska-KornackaEwa Gulczy¿skaAgnieszka KordekPiotr Heczko Source Type: research

Anticoagulating the subsegmental pulmonary embolism in cancer patients: a survey amongst different medical specialties
Abstract The clinical significance of isolated subsegmental pulmonary embolism (SSPE) remains an area of controversy. In cancer patients, venous thromboembolism (VTE) is common and is a major cause of morbidity and mortality. The management of overt VTE in cancer patients is well established, nevertheless the management of incidentally diagnosed PE and especially SSPE, an increasingly frequent finding with the ubiquity of thin-slice computed tomography is less well defined. We have surveyed current attitudes towards treating SSPE in cancer patients among oncologists, respiratory and palliative care physicians. The...
Source: Journal of Thrombosis and Thrombolysis - October 18, 2014 Category: Hematology Source Type: research

Anesthetic management in a child with Rolland-Desbuquois type dyssegmental dysplasia
A case of a 17-month-old boy with dissegmental dysplasia of the Rolland-Desbuquois type, who was scheduled for bilateral inguinal herniotomy, is presented. Preoperative assessment showed limited mouth opening, head extension, and kyphosis. Intubation with a size 4 mm endotracheal tube (ETT) was achieved with fiberoptic bronchoscopy, after which surgery proceeded uneventfully and the ETT was carefully removed. Copious airway secretions required frequent suctioning. On the second postoperative day, respiratory status stabilized, and the patient was discharged home. (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - October 18, 2014 Category: Anesthesiology Authors: Ryu Okutani, Yu Arima, Yutaka Oda Tags: Case report Source Type: research

Capnography (ETCO), Respiratory Depression, and Nursing Interventions in Moderately Sedated Adults Undergoing Transesophageal Echocardiography (TEE)
Little attention has been paid to the safety of moderate sedation given to adult patients undergoing transesophageal echocardiography (TEE). Although capnography has been found to indicate respiratory depression earlier than pulse oximetry in other sedation scenarios, its usefulness during TEE has not been clearly documented. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - October 18, 2014 Category: Nursing Authors: Linda Adams, Susan Butas, Darrell Spurlock Tags: Research Source Type: research

Effectiveness of prayer in reducing anxiety in cancer patients
Conclusion: Prayer, therefore, proved to be an effective strategy in reducing the anxiety of the patient undergoing chemotherapy.


Objetivo: Evaluar el efecto de la plegaria sobre la ansiedad de pacientes con cáncer en tratamiento quimioterápico. Método: Estudio casi experimental con pre y post intervención. Fueron reclutados 20 pacientes hospitalizados en tratamiento de quimioterapia endovensa continua. Los voluntarios fueron evaluados por medio de encuesta, utilizándose un cuestionario de rasgos sociodemográficos, clínicos y espirituales, el Índice de Religiosidad de la Universidad de Duke - DUREL y el Inv...
Source: Revista da Escola de Enfermagem da USP - October 17, 2014 Category: Nursing Source Type: research

A Sphingosine-1 Phosphate Agonist (FTY720) Limits Trauma/Hemorrhagic Shock–Induced Multiple Organ Dysfunction Syndrome
Conclusions: FTY720 limited T/HS-induced multiple organ dysfunction syndrome (lung injury, red cell injury, and neutrophil priming) as well as T/HS lymph bioactivity, although it did not limit gut injury. (Source: Shock)
Source: Shock - October 17, 2014 Category: Emergency Medicine Tags: Basic Science Aspects Source Type: research

Motion Compensation for Ultrasound Thermal Imaging Using Motion-Mapped Reference Model: An in vivo Mouse Study
In this study, we aim to develop a motion compensation method for stable US thermal imaging in in vivo subjects. Based on the assumption that the major tissue motion is approximately periodic caused by respiration, we propose a motion compensation method for change in backscattered energy (CBE) with multiple reference frames. Among the reference frames, the most similar reference to the current frame is selected to subtract the respiratory-induced motions. Since exhaustive reference searching in all stored reference frames can impede real-time thermal imaging, we improve the reference searching by using a motion-mapped ref...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

Nasal Oestrosis in a Jamunapari goat
Abstract Oestrus ovis is a well-known parasite of the nasal cavities and adjoining sinuses in sheep and goats. A 3-year-old female Jamunapari goat was presented with a history of anorexia, weight loss, in-coordinated movements, nasal discharge since 10 days and two nasal bots expelled during sneezing 3 days back. Upon clinical examination the animal was dull, dysphonic, unsteady gait and having blocked nostrils with thick mucoid discharge along with an increased respiratory rate. Parasitiological examination revealed it as an O. ovis (nasal bots). The occurrence of nasal bots in a goat an...
Source: Journal of Parasitic Diseases - October 17, 2014 Category: Parasitology Source Type: research

GAL-021, a new intravenous BKCa-channel blocker, is well tolerated and stimulates ventilation in healthy volunteers
Conclusions GAL-021 was safe and generally well tolerated with adverse events comparable with placebo except for an infusion site burning sensation. GAL-021 stimulated ventilation at the highest doses suggesting that greater infusion rates may be required for maximum PD effects. GAL-021 had PK characteristics consistent with an acute care medication. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - October 17, 2014 Category: Anesthesiology Authors: McLeod, J. F., Leempoels, J. M., Peng, S. X., Dax, S. L., Myers, L. J., Golder, F. J. Tags: Respiration And The Airway Source Type: research

Traumatic massive tension pneumothorax due to a break in the middle lobe bronchus
A patient presented respiratory failure and haemodynamic instability after falling from a height of 6 m. After a high suspicion of tension pneumothorax based on clinical status and pulmonary auscultation, the emergency physician inserted a Pneumocath (8 Fr; 2.7 mm) while in the ambulance. Once in hospital, CT scan (figure 1) showed a tension pneumothorax that caused an important left displacement of the heart, right diaphragm and hepatic silhouette. These findings led to replacing the chest tube by a thicker one (Argyle Thoracic Catheter 28 Fr; 9.3 mm). Due to the presence of massive and persistent...
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Carillo, G. A. O., Fontan, E. M. G. Tags: Radiology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ethics, Trauma Images in emergency medicine Source Type: research

Pyrethroid poisoning: features and predictors of atypical presentations
Conclusions 39.3% of pyrethroid poisoned patients had atypical presentations with the most common being respiratory failure requiring ventilator care. Predictors of atypical presentation were ingested amount >250 cc and serum lactate >3.5 mmol/L. (Source: Emergency Medicine Journal)
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Cha, Y. S., Kim, H., Cho, N. H., Jung, W. J., Kim, Y. W., Kim, T. H., Kim, O. H., Cha, K. C., Lee, K. H., Hwang, S. O., Nelson, L. S. Tags: Poisoning/Injestion, Pneumonia (infectious disease), TB and other respiratory infections, Coma and raised intracranial pressure, Epilepsy and seizures, Hypertension, Pneumonia (respiratory medicine), Poisoning Original article Source Type: research

Tension pneumoperitoneum
Image case history An elderly female with peritoneal carcinomatosis of ovarian origin was resuscitated following a pulseless electrical activity (PEA) cardiac arrest. Prehospital intubation attempts were unsuccessful and the patient received bag-valve-mask ventilation. En route, paramedics reported increasing difficulty ventilating and the patient's abdomen became distended, tense and tympanitic. After emergency department arrival, a postintubation radiograph of the chest was obtained (figure 1). Tension pneumoperitoneum was diagnosed and abdominal decompression with a supraumbilical needle was performed. Despite initial i...
Source: Emergency Medicine Journal - October 17, 2014 Category: Emergency Medicine Authors: Williams, D. T., Manoochehri, P., Kim, H. T. Tags: Patients, Drugs: cardiovascular system, Radiology, Surgical diagnostic tests, Clinical diagnostic tests, Radiology (diagnostics), Ethics, Resuscitation Images in emergency medicine Source Type: research

Comparison between breathing and aerobic exercise on clinical control in patients with moderate-to-severe asthma: protocol of a randomized trial
DiscussionAlthough the benefits of breathing and aerobic exercises have been extensively studied, the comparison between both has never been investigated. Furthermore, the findings of our results will allow us to understand its application and suitability to patients that will have more benefits for every intervention optimizing its effect.Trial registration: Clinicaltrials.gov; Identifier: NCT02065258. (Source: BMC Pulmonary Medicine)
Source: BMC Pulmonary Medicine - October 17, 2014 Category: Respiratory Medicine Authors: Karen EvaristoMilene SaccomaniMilton MartinsAlberto CukierRafael StelmachMarcos RodriguesDanilo SantaellaCelso Carvalho Source Type: research

Travel-related MERS-CoV cases: an assessment of exposures and risk factors in a group of Dutch travellers returning from the Kingdom of Saudi Arabia, May 2014
Conclusions: This epidemiological study revealed the complexity of MERS-CoV outbreak investigations with multiple potential exposures to MERS-CoV reported such as healthcare visits, camel exposure, and exposure to untreated food products. Exposure to MERS-CoV during a hospital visit is considered a likely source of infection for Case 1 but not for Case 2. For Case 2, the most likely source could not be determined. Exposure to MERS-CoV via direct contact with animals or dairy products seems unlikely for the two Dutch cases. Furthermore, exposure to a common but still unidentified source cannot be ruled out. More comprehensi...
Source: Emerging Themes in Epidemiology - October 17, 2014 Category: Epidemiology Authors: Ewout FanoyMarianne van der SandeMarleen Kraaij-DirkzwagerKees DirksenMarcel JongesWim van der HoekMarion KoopmansDouwe van der WerfGerard SonderCharlie van der WeijdenJet van der HeuvelLuc GelinckJolande BouwhuisArianne van Gageldonk-LafeberMERS-CoV outb Source Type: research

The Influence of Parenting on Early Childhood Health and Health Care Utilization
Conclusions This study highlights the importance of considering parenting practices when examining variations in early childhood health and health care, and the relevance of parental behavior in designing interventions for high-risk populations. (Source: Journal of Pediatric Psychology)
Source: Journal of Pediatric Psychology - October 17, 2014 Category: Pediatrics Authors: Serbin, L. A., Hubert, M., Hastings, P. D., Stack, D. M., Schwartzman, A. E. Tags: Regular Articles Source Type: research

Contemporary economic and clinical evaluations of endovascular repair for intact descending thoracic aortic aneurysms.
CONCLUSIONS: This study supports satisfying immediate clinical outcomes for TEVAR and TEVAR + surgical infrarenal procedures. Although limited by a small population size and difficulties in economic comparisons, this study presents the real world social and economic cost scenario for both elective TEVAR and TEVAR hybrid treatment of DTAA of both the in--hospital and at mid term follow--up periods. PMID: 25323106 [PubMed - as supplied by publisher] (Source: The Journal of Cardiovascular Surgery)
Source: The Journal of Cardiovascular Surgery - October 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Coppi G, Chester J, Gennai S, Silingardi R, Marcheselli L, Brunetti M Tags: J Cardiovasc Surg (Torino) Source Type: research

Does a non-invasive hemoglobin monitor correlate with a venous blood sample in the acutely ill?
Abstract Non-invasive hemoglobin measuring technology has potential for rapid, portable, and accurate way of providing identification of blood loss or anemia. Our objective is to determine if this technology is reliable in critically ill patients presenting to the Emergency Department. Prospective cross-sectional observational study was done at an urban level-one trauma center, 135 subjects were conveniently sampled, suspected of having active bleeding, sepsis, or other critically ill condition. Non-invasive measurements with Masimo (Irvine, CA, USA) Radical-7 and Rad-57 hemoglobin monitors were compared with the ...
Source: Internal and Emergency Medicine - October 17, 2014 Category: Emergency Medicine Source Type: research

Optogenetic Stimulation of Adrenergic C1 Neurons Causes Sleep State Dependent Cardiorespiratory Stimulation and Arousal with Sighs in Rats.
Conclusions: C1 cell stimulation reproduces most effects of acute hypoxia, specifically cardiorespiratory stimulation, sighs and arousal. C1 cell activation likely contributes to the sleep disruption and adverse autonomic consequences of sleep apnea. During hypoxia (awake) or REM sleep, C1 cell stimulation increases BP but no longer stimulates breathing. PMID: 25325789 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 17, 2014 Category: Respiratory Medicine Authors: Burke PG, Abbott SB, Coates MB, Viar KE, Stornetta RL, Guyenet PG Tags: Am J Respir Crit Care Med Source Type: research

Successful ultrasound imaging of pulmonary sub-pleural hamartoma
Abstract Pulmonary hamartoma, a common benign tumor of the lung, often presents as a solitary nodule on the peripheral lung, and is mainly composed of bronchial mucosa epithelial cells, chondrocytes, and adipose cells. Here, we report the case of a 42-year-old female who had a lung nodule that appeared as a homogeneous high-density shadow of a peripheral localization on chest computed tomography scan. For further evaluation, transthoracic ultrasonography examination was performed, which revealed a round, heterogenous, hypoechoic mass attached to the visceral pleura and showing obvious respiratory motions on the re...
Source: Journal of Medical Ultrasonics - October 17, 2014 Category: Radiology Source Type: research

Smoking Cessation Intervention Within the Framework of a Lung Cancer Screening Program: Preliminary Results and Clinical Perspectives from the “Cosmos-II” Trial
Abstract Data coming from the literature investigating the effectiveness and interaction between smoking cessation (SC) and lung cancer screening (LCScr) are still sparse and inconsistent. Herein, we report the preliminary results from the ongoing lung cancer screening trial (“Cosmos-II”) focusing our analysis on the inter-relationship between the SC program and the LCScr. (Source: Lung)
Source: Lung - October 17, 2014 Category: Respiratory Medicine Source Type: research

The Airway Colonization by Opportunistic Filamentous Fungi in Patients with Cystic Fibrosis: Recent Updates
Abstract There has been a remarkable increase recently in the isolation of fungi such as Aspergillus fumigatus, species of the Pseudallescheria boydii/Scedosporium apiospermum complex, and Exophiala sp. from the respiratory tract of patients with cystic fibrosis (CF). This review describes the recent insights into the epidemiology, ecology, and physiopathology of the filamentous fungi able to colonize and/or to infect the airways of CF patients, and that may be responsible for accelerated lung function decline. We summarize salient features not only on highly prevalent species such as Aspergillus and Scedosporium,...
Source: Current Fungal Infection Reports - October 17, 2014 Category: Infectious Diseases Source Type: research

Noninvasive Ventilation During Procedural Sedation in the Emergency Department: A Case Series
Procedural sedation and analgesia (PSA) is the administration of sedative, analgesic, or dissociative agents to facilitate painful or unpleasant procedures. The most important complication during PSA is hypoventilation, which may result from compromise of the airway or respiratory drive. While emergency physicians have a conclusive record of safety in using a variety of PSA agents to facilitate painful procedures across the sedation continuum,1 EDs serve an aging population that is burdened with high rates of obesity;2,3 emergency providers are therefore more likely to perform PSA on patients with high anesthetic risk. (So...
Source: The American Journal of Emergency Medicine - October 17, 2014 Category: Emergency Medicine Authors: Reuben J. Strayer, Nicholas D. Caputo Tags: Correspondence Source Type: research

Thiopseudomonas denitrificans gen. nov. sp. nov., isolated from anaerobic activated sludge.
Abstract A Gram-staining-negative, rod-shaped, motile and facultative anaerobic bacterial strain, designated X2T, was isolated from the sludge of an anaerobic denitrifying sulfide removal bioreactor, and sulfide is oxidized anaerobically with nitrate as electron acceptor. The strain grew at salinities of 0-3% (w/v) NaCl (optimum, 0-1 %). Growth occurred at pH 6.0-10.0 (optimum, pH 8.0) and 10-37°C (optimum, 30°C). The genomic DNA G+C content was 59 mol%. Q-8 and Q-9 were detected as the respiratory quinones. The major fatty acids (>10%) were C16:1ω7c and/or C16:1ω6c, C18:1ω7c and C16:0. The polar lipids con...
Source: International Journal of Systematic and Evolutionary Microbiology - October 17, 2014 Category: Microbiology Authors: Tan WB, Jiang Z, Chen C, Yuan Y, Gao LF, Wang HF, Cheng J, Li WJ, Wang AJ Tags: Int J Syst Evol Microbiol Source Type: research

Kiloniella spongiae sp. nov., isolated from a marine sponge and emended description of the genus Kiloniella Wiese et al. 2009 and Kiloniella laminariae.
Abstract A Gram-reaction-negative, aerobic, rod-shaped and non-motile marine bacterium, designated MEBiC09566T was isolated from a sponge collected at Uljin County in the coastal area of the East Sea (129°25'E, 36°55' N), Korea. The 16S rRNA gene sequence analysis revealed that strain MEBiC09566T showed the highest similarity with the Kiloniella laminariae LD81T (96.7%). Growth was observed at 11-31 OC (optimum 25 OC), at pH 6.0-8.5 (optimum pH 7.0) and with 0-6 % (optimum 2.5%) NaCl. The predominant cellular fatty acids were summed feature 8 (comprised of C18:1ω7c/ C18:1ω6c; 63.1%) and summed feature 3 (compri...
Source: International Journal of Systematic and Evolutionary Microbiology - October 17, 2014 Category: Microbiology Authors: Yang SH, Seo HS, Lee JH, Kim SJ, Kwon KK Tags: Int J Syst Evol Microbiol Source Type: research