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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 8.

Evaluation of oxygen prescription in relation to hospital admission rate in patients with chronic obstructive pulmonary disease
Conclusions: Admission to hospital is more likely in LTOT users, independent of COPD severity. Oxygen use outside NICE guidance does not appear to prevent admissions. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 5, 2014 Category: Respiratory Medicine Authors: Alice TurnerSourav SenCathryn SteeleyYasmin KhanPamela SweeneyYvonne RichardsRahul Mukherjee Source Type: research

Nitric oxide exerts protective effects against bleomycin-induced pulmonary fibrosis in mice
Conclusions: These results provide the first direct evidence that a lack of all three NOS isoforms led to a deterioration of pulmonary fibrosis in a BLM-treated murine model. We speculate that the entire endogenous NO and NOS system plays an important protective role in the pathogenesis of pulmonary fibrosis. (Source: Respiratory Research)
Source: Respiratory Research - August 5, 2014 Category: Respiratory Medicine Authors: Shingo NoguchiKazuhiro YateraKe-Yong WangKeishi OdaKentarou AkataKei YamasakiToshinori KawanamiHiroshi IshimotoYumiko ToyohiraHiroaki ShimokawaNobuyuki YanagiharaMasato TsutsuiHiroshi Mukae Source Type: research

Profile of organ dysfunction and predictors of mortality in severe scrub typhus infection requiring intensive care admission
Conclusions: In this cohort of severe scrub typhus infection with multi-organ dysfunction, survival was good despite high severity of illness scores. APACHE-II score and duration of fever independently predicted mortality. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 5, 2014 Category: Intensive Care Authors: Mathew GriffithJohn Victor PeterGunasekaran KarthikKartik RamakrishnaJohn Antony Jude PrakashRajamanickam C KalkiGeorge M VargheseAnugragh ChrispalKishore PichamuthuRamya IyyaduraiOoriapadickal Cherian Abraham Source Type: research

Compliance versus dead space for optimum positive end expiratory pressure determination in acute respiratory distress syndrome
Conclusion: Vd guided PEEP improved compliance and oxygenation with less Ppl. Hence, its use as a guide for best PEEP determination may be useful. (Source: Indian Journal of Critical Care Medicine)
Source: Indian Journal of Critical Care Medicine - August 5, 2014 Category: Intensive Care Authors: Ghada Fouad El-BaradeyNagat Sayed El-Shamaa Source Type: research

Elevated CXCL-8 expression in bronchoalveolar lavage correlates with disease severity in patients with Acute Respiratory Distress Syndrome resulting from tuberculosis
Conclusions: BAL CXCL8 levels were significantly higher in patients with ARDS induced by TB and could suggest an important role of CXCL8 in the pathogenesis of this form of ARDS. This further suggests that CXCL8 inhibitors or blockers may be useful to control the onset and/or development of these combined diseases. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - August 5, 2014 Category: Epidemiology Authors: Seyed Mohamad HashemianEsmaeil MortazPayam TabarsiHamidreza JamaatiZohreh MaghsoomiAdnan KhosraviJohan GarssenMohamad Reza MasjediAli Akbar VelayatiGert FolkertsPeter J BarnesIan M Adcock Source Type: research

hRSV N inhibits the T-cell immune synapse [Immunology and Inflammation]
Human respiratory syncytial virus (hRSV) is the leading cause of bronchiolitis and pneumonia in young children worldwide. The recurrent hRSV outbreaks and reinfections are the cause of a significant public health burden and associate with an inefficient antiviral immunity, even after disease resolution. Although several mouse- and human cell-based studies... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 5, 2014 Category: Science Authors: Cespedes, P. F., Bueno, S. M., Ramirez, B. A., Gomez, R. S., Riquelme, S. A., Palavecino, C. E., Mackern–Oberti, J. P., Mora, J. E., Depoil, D., Sacristan, C., Cammer, M., Creneguy, A., Nguyen, T. H., Riedel, C. A., Dustin, M. L., Kalergis, A. M. Tags: PNAS Plus Source Type: research

Metaproteomics of coupled biogeochemical cycling [Environmental Sciences]
Marine oxygen minimum zones (OMZs) are intrinsic water column features arising from respiratory oxygen demand during organic matter degradation in stratified waters. Currently OMZs are expanding due to global climate change with resulting feedback on marine ecosystem function. Here we use metaproteomics to chart spatial and temporal patterns of gene... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 5, 2014 Category: Science Authors: Hawley, A. K., Brewer, H. M., Norbeck, A. D., Paša–Tolić, L., Hallam, S. J. Tags: Biological Sciences Source Type: research

Binding of human factor H to outer membrane protein P5 of non‐typeable Haemophilus influenzae contributes to complement resistance
Abstract Non‐typeable Haemophilus influenzae is an opportunistic pathogen of the human upper respiratory tract and is often found to cause inflammatory diseases that include sinusitis, otitis media and exacerbations of chronic obstructive pulmonary disease. To persist in the inflammatory milieu during infection, non‐typeable Haemophilus influenzae must resist the antimicrobial activity of the human complement system. Here, we used Tn‐seq to identify genes important for resistance to complement‐mediated killing. This screen identified outer membrane protein P5 in evasion of the alternative pathway of complement acti...
Source: Molecular Microbiology - August 5, 2014 Category: Microbiology Authors: Jeroen D. Langereis, Marien I. de Jonge, Jeffrey N. Weiser Tags: Research Article Source Type: research

Distribution and antimicrobial susceptibility profile of extended-spectrum β-lactamase-producing strains recently isolated in Japan
Proteus mirabilis is a causative agent of healthcare-associated infections (HCAIs), including urinary tract, respiratory tract and skin infections [1–3]. As HCAIs associated with this organism are often associated with horizontal transmission through urine specimens [4], monitoring is required for early detection and intervention. Since this organism is prevalent in the environment, including contaminated water, soil and animals [3], the spread of antimicrobial-resistant P. mirabilis is a widespread public health problem and is not restricted to the hospital environment. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - August 5, 2014 Category: Drugs & Pharmacology Authors: Akiko Kanayama, Intetsu Kobayashi, Kazutoshi Shibuya Source Type: research

IFN‐γ CA microsatellite polymorphism is associated with susceptibility to respiratory syncytial virus Infection and severity
ConclusionIFN‐γ CA microsatellite polymorphism was associated with the susceptibility of Chinese Han children to RSV and the severity of the infection.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - August 5, 2014 Category: Pediatrics Authors: Jianfeng Huang, Mingzhi Zhang, Xiaobo Zhang, Aizhen Lu, Libo Wang, Chao Chen Tags: Regular Article Source Type: research

Surfactant protein A mediates pulmonary clearance of
Surfactant protein A has been shown to enhance opsonization and clearance of Staphylococcus aureus in vitro. Here, the phagocytosis of alveolar S. aureus was investigated in vivo using intravital microscopy. Fluorescence labelled S. aureus Newman cells were intratracheally administered to anesthetized mice and the alveolar surface was observed for fifteen minutes. Confirming previously reported in vitro data, surfactant protein A-deficient mice showed a significantly reduced uptake of bacteria compared to wild-type mice. (Source: Respiratory Research)
Source: Respiratory Research - August 5, 2014 Category: Respiratory Medicine Authors: Nils VeithThomas TschernigBirgitt GutbierMartin WitzenrathCarola MeierMichael MengerMarkus Bischoff Source Type: research

Central venous thrombosis and thrombophilia in cystic fibrosis: A prospective study
Catheter venous thrombosis may result in life-threatening embolic complications. Recently, a thrombophilic tendency was described in cystic fibrosis (CF), the significance of which remains unclear. The aims of this study were to (1) document the frequency of catheter venous thrombosis detected by colour-Doppler-ultrasound (Doppler-US), (2) assess genetic and acquired thrombophilia risk factors for catheter venous thrombosis and hypercoagulability status and (3) provide recommendations on laboratory screening when considering insertion of a totally implantable vascular access device (TIVAD) in CF patients. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - August 5, 2014 Category: Respiratory Medicine Authors: Anne Munck, Ahmed Kheniche, Corinne Alberti, Dominique Hubert, Reynaud-Gaubert Martine, Raphaele Nove-Josserand, Isabelle Pin, Francois Bremont, Raphael Chiron, Laure Couderc, Marie Laure Dalphin, Estelle Darviot, Bertrand Delaisi, Stéphane Dominique, Is Source Type: research

Induction of innate immune responses by flagellin from the intracellular bacterium, `
Conclusion: The flagellin of Lso and its functional domain, flg22 Lso share characteristics of pathogen-associated molecular patterns, and trigger unique innate immune responses in N. benthamiana. Slow and weak activation of the innate immune response in host plants by the flagellin of Lso may reflect the nature of its intracellular life cycle. Our findings provide new insights into the role of the Lso flagellin in the development of potato zebra chip disease and potential application in breeding for resistance. (Source: BMC Plant Biology - Latest articles)
Source: BMC Plant Biology - Latest articles - August 5, 2014 Category: Biology Authors: Guixia HaoMarco PitinoFang DingHong LinEd StoverYongping Duan Source Type: research

Spatial epidemiology of porcine reproductive and respiratory syndrome in Thailand
Conclusions: The results indicated that farms with breeding sows may be an important group for targeted surveillance and control. However, these findings obtained at the sub-district level should be complemented by farm-level epidemiological investigations in order to obtain a more comprehensive view of the factors affecting PRRS presence. In this study, the outbreaks of PRRS could not be differentiated from the potential novel HP-PPRS form, which was recently discovered in the country. (Source: BMC Veterinary Research - Latest articles)
Source: BMC Veterinary Research - Latest articles - August 5, 2014 Category: Veterinary Research Authors: Weerapong ThanapongtharmCatherine LinardNutavadee PamaranonSarayuth KawkalongTanom NoimohKaroon ChanachaiTippawon ParakgamawongsaMarius Gilbert Source Type: research

Human metapneumovirus prevalence and molecular epidemiology in respiratory outbreaks in Ontario, Canada
The objective of this study was to document respiratory outbreaks that were caused by hMPV in Ontario, Canada and to identify the various circulating genotypes during April 2009–February 2012. The majority of the outbreaks that were part of this study were in adults (>65 years). Total nucleic acid extraction was done on 123 residual anonymized clinical specimens from 51 different respiratory outbreaks. Specimens were subjected to PCR amplification and Sanger sequencing targeting the F and G genes of hMPV. Phylogenetic analysis was performed to identify genotypes. HMPV accounted for 195 (8.5%) of 2,292 respiratory outb...
Source: Journal of Medical Virology - August 5, 2014 Category: Virology Authors: Alefiya Neemuchwala, Venkata R. Duvvuri, Alex Marchand‐Austin, Aimin Li, Jonathan B. Gubbay Tags: Research Article Source Type: research

The role of microbes in the pathogenesis of acute rhinosinusitis in young adults
ConclusionNasal and paranasal H. influenzae coinfection during viral infection may modify the symptoms and the extent of sinonasal mucosal disease observed in CBCT scans already from the beginning of the ARS episode. Level of EvidenceN/A. Laryngoscope, 2014 (Source: The Laryngoscope)
Source: The Laryngoscope - August 5, 2014 Category: ENT & OMF Authors: Timo J. Autio, Terhi Tapiainen, Timo Koskenkorva, Mervi Närkiö, Maija Lappalainen, Simo Nikkari, Heidi Hemmilä, Katja A. Koskela, Markku Koskela, Petri Koivunen, Olli‐Pekka Alho Tags: Allergy/Rhinology Source Type: research

Electrical alternans due to large bilateral pleural effusion without pericardial effusion
A 53-year-old woman, with a history of breast cancer presented with acute respiratory failure (arterial oxygen saturation 87% while the patient was breathing 15L/min of oxygen) and pulsus paradoxus in the setting of sepsis and acute renal failure. Electrocardiogram showed electrical alternans associated with 2/1 intermittent precordial ST-segment elevation (panel A, arrows). Bedside echocardiography showed left ventricular systolic dysfunction associated with large bilateral pleural effusions (white arrows) and small pericardial effusion (asterisk) (panels B, C and video). (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - August 5, 2014 Category: Cardiology Authors: Benoît Berthoud, Pierre-Vladimir Ennezat Source Type: research

Enhanced Tracheostomy Wound Healing Using Maltodextrin and Silver Alginate Compounds in Pediatrics: A Pilot Study.
CONCLUSIONS: Postoperative tracheostomy wounds are common. The use of MD and AG provides an effective and safe treatment for tracheostomy-related ulcers. PMID: 25096405 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 5, 2014 Category: Respiratory Medicine Authors: Hartzell LD, Havens TN, Odom BH, Stillman TG, Boswell JL, Bower CM, Richter GT Tags: Respir Care Source Type: research

Psychrobium conchae gen. nov, sp. nov., a psychrophilic marine bacterium isolated from the Iheya North hydrothermal field, Okinawa Trough, off Japan.
Abstract A novel psychrophilic marine bacterial strain designated BJ-1T was isolated from the Iheya North hydrothermal field, Okinawa Trough off Japan. Cells were Gram-negative, rod-shaped, non-spore-forming aerobic chemo-organotrophs and motile by means of a single polar flagellum. Growth occurred at temperatures below 16 °C, with the optimum between 9 and 12 °C. Phylogenetic analysis based on the 16S rRNA gene sequence indicated that the closest relatives of strain BJ-1T were Shewanella denitrificans OS-217T (93.5 %), Shewanella profunda DSM 15900T (92.9 %), Shewanella gaetbuli TF-27T (92.9 %), Paraferrimonas s...
Source: International Journal of Systematic and Evolutionary Microbiology - August 5, 2014 Category: Microbiology Authors: Nogi Y, Abe M, Kawagucci S, Hirayama H Tags: Int J Syst Evol Microbiol Source Type: research

Molecular cloning and characterizations of porcine SAMHD1 and its roles in replication of highly pathogenic porcine reproductive and respiratory syndrome virus.
Abstract The sterile alpha motif and HD domain 1 (SAMHD1) protein is a novel innate immunity restriction factor that inhibits HIV-1 infection in myeloid cells. Here, we cloned the full-length SAMHD1 complementary DNA (cDNA) from porcine peripheral blood lymphocytes. The porcine SAMHD1 cDNA was of 3951 bp with an open reading frame of 1884 bp, encoding a polypeptide of 627 amino acids. Porcine SAMHD1 mRNA was detected in all swine tissues examined, with the higher expression in the tonsil, lung, liver, and lymph node tissues. The SAMHD1 protein was localized to the nucleus. Overexpression of SAMHD1 blocked the p...
Source: Developmental and Comparative Immunology - August 5, 2014 Category: Allergy & Immunology Authors: Yang S, Shan T, Zhou Y, Jiang Y, Tong W, Liu F, Wen F, Zhang Q, Tong G Tags: Dev Comp Immunol Source Type: research

Use of Amiodarone After Major Lung Resection.
CONCLUSIONS: Atrial fibrillation that occurs without an antecedent respiratory complication in patients after major lung resection results in longer hospital stay but not increased mortality or respiratory morbidity. Using amiodarone to treat atrial fibrillation after major lung resection is not associated with an increased incidence of respiratory complications. PMID: 25106684 [PubMed - as supplied by publisher] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - August 5, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Berry MF, D'Amico TA, Onaitis MW Tags: Ann Thorac Surg Source Type: research

CD18 deficiency evolving to megakaryocytic (M7) acute myeloid leukemia: Case report.
Abstract Leukocyte adhesion deficiency type 1 (LAD 1 - CD18 deficiency) is a rare disease characterized by disturbance of phagocyte function associated with less severe cellular and humoral dysfunction. The main features are bacterial and fungal infections predominantly in the skin and mucosal surfaces, impaired wound healing and delayed umbilical cord separation. The infections are indolent, necrotic and recurrent. In contrast to the striking difficulties in defense against bacterial and fungal microorganisms, LAD 1 patients do not exhibit susceptibility to viral infections and neoplasias. The severity of clinical...
Source: Blood Cells, Molecules and Diseases - August 5, 2014 Category: Hematology Authors: de Moraes Vasconcelos D, Beitler B, Martinez GA, Pereira J, Amigo Filho JU, Klautau GB, Lian YC, Della Negra M, Duarte AJ Tags: Blood Cells Mol Dis Source Type: research

Elective Cesarean Section at 37 Weeks Is Associated with the Higher Risk of Neonatal Complications.
In conclusion, the incidence of neonatal complications was higher in newborns delivered at 37 weeks of gestation than in those delivered at 38 weeks via elective Cesarean section. Thus, the procedure should be scheduled at 38 weeks to improve neonatal outcomes. PMID: 25078250 [PubMed - as supplied by publisher] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - August 4, 2014 Category: Research Authors: Nakashima JI, Yamanouchi S, Sekiya SI, Hirabayashi M, Mine K, Ohashi A, Tsuji S, Kasamatsu A, Kanzaki H, Hirano D, Kaneko K Tags: Tohoku J Exp Med Source Type: research

Considerations for Designing In Vitro Bioequivalence (IVBE) Studies for Pressurized Metered Dose Inhalers (pMDIs) with Spacer or Valved Holding Chamber (S/VHC) Add-on Devices
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - August 4, 2014 Category: Respiratory Medicine Tags: article Source Type: research

Alveolar nitric oxide and its role in pediatric asthma control assessment
Conclusions: The results for CANO and JawNO in controls were similar to those found in other reports. There was no agreement or only slight agreement among the three measure instruments analyzed to assess asthma control. In our sample, no additional information was provided by CANO and JawNO. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 4, 2014 Category: Respiratory Medicine Authors: Olaia SardónPaula CorcueraAne AldasoroJavier KortaJavier MinteguiJosé EmparanzaEduardo Pérez-Yarza Source Type: research

A controlled study of community-based exercise training in patients with moderate COPD
Conclusions: We demonstrated the feasibility and effectiveness of a novel community-based exercise program involving health clubs and personal trainers for patients with moderate COPD.Trial registration: Identifier NCT01985529. (Source: BMC Pulmonary Medicine - Latest articles)
Source: BMC Pulmonary Medicine - Latest articles - August 4, 2014 Category: Respiratory Medicine Authors: Shefalee AminMarlon AbrazadoMolly QuinnThomas StorerChi-Hong TsengChristopher Cooper Source Type: research

Diagnostic value of suPAR in differentiating noncardiac pleural effusions from cardiac pleural effusions
ConclusionssuPAR is a potential new marker for the discrimination between cardiac and noncardiac PF. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 4, 2014 Category: Respiratory Medicine Authors: Savas Ozsu, Funda Oztuna, Ahmet Mentese, Yasin Abul, Tevfik Ozlu Tags: Original Article Source Type: research

Nondisseminated histoplasmosis of the trachea
We report the case of a 68‐year‐old woman with rheumatoid arthritis on immunosuppressive therapy who presented with fevers, worsening shortness of breath, nonproductive cough and subjective throat hoarseness and fullness. Chest computed tomography demonstrated no tracheal findings. Bronchoscopy found mucosal irregularity, nodularity and vesicular regions in the proximal trachea extending seven centimeters distal to the vocal cords. Also seen was an edematous, exudative left vocal cord with polyps and an ulcerative lesion. Silver staining and culture and wash of the tracheal biopsy revealed Histoplasma capsulatum. She w...
Source: The Clinical Respiratory Journal - August 4, 2014 Category: Respiratory Medicine Authors: Nicholas Bhojwani, Jason Brett Hartman, David C. Taylor, Mark Herbert, Michael Corriveau Tags: Other Source Type: research

Laryngopharyngeal symptoms in patients with asthma: a cross‐sectional controlled study
ConclusionLaryngopharyngeal reflux disease is more prevalent and more severe in patients with asthma vs controls. (Source: The Clinical Respiratory Journal)
Source: The Clinical Respiratory Journal - August 4, 2014 Category: Respiratory Medicine Authors: Abdul Latif Hamdan, Hussein Jaffal, Rachel Btaiche, Zaahir A. Turfe, Ibrahim Bawab, Nadim Kanj, Hani Tamim Tags: Original Article Source Type: research

Mechanism of Action of Lung Damage Caused by a Nanofilm Spray Product
Inhalation of waterproofing spray products has on several occasions caused lung damage, which in some cases was fatal. The present study aims to elucidate the mechanism of action of a nanofilm spray product, which has been shown to possess unusual toxic effects, including an extremely steep concentration-effect curve. The nanofilm product is intended for application on non-absorbing flooring materials and contains perfluorosiloxane as the active film-forming component. The toxicological effects and their underlying mechanisms of this product were studied using a mouse inhalation model, by in vitro techniques and by identif...
Source: Toxicological Sciences - August 4, 2014 Category: Toxicology Authors: Larsen, S. T., Dallot, C., Larsen, S. W., Rose, F., Poulsen, S. S., Norgaard, A. W., Hansen, J. S., Sorli, J. B., Nielsen, G. D., Foged, C. Tags: Inhalation and Respiratory Respiratory Toxicology Source Type: research

Laser surgery as a management option for twin anemia–polycythemia sequence
ConclusionsLaser surgery for TAPS appears to improve perinatal outcome by prolonging pregnancy and reducing respiratory distress syndrome. Larger, adequately controlled studies are needed to reach firm conclusions on the optimal management of TAPS. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd. (Source: Ultrasound in Obstetrics and Gynecology)
Source: Ultrasound in Obstetrics and Gynecology - August 4, 2014 Category: Radiology Authors: F. Slaghekke, R. Favre, S. H. P. Peeters, J. M. Middeldorp, A. S. Weingertner, E. W. van Zwet, F. J. Klumper, D. Oepkes, E. Lopriore Tags: Original Article Source Type: research

Cohort Profile: The Study of Respiratory Pathogens in Andean Children
We investigated respiratory pathogens in a prospective cohort study of young children living in the Peruvian Andes. In the study we assessed viral respiratory infections among young children, and explored interactions of viruses with common respiratory bacteria, especially Streptococcus pneumoniae. Through weekly household visits, data were collected on the signs and symptoms of acute respiratory illness (ARI), nasal samples were collected to test for viruses during episodes of ARI, and nasopharyngeal samples were collected on a monthly basis to monitor bacterial colonisation. We also collected data on vaccination coverage...
Source: International Journal of Epidemiology - August 4, 2014 Category: Epidemiology Authors: Grijalva, C. G., Griffin, M. R., Edwards, K. M., Williams, J. V., Gil, A. I., Verastegui, H., Hartinger, S. M., Vidal, J. E., Klugman, K. P., Lanata, C. F. Tags: Cohort Profiles Source Type: research

Cohort Profile: The Limache, Chile, birth cohort study
The Limache cohort was set up to assess the programming and life course events hypotheses in relation to cardiovascular risk factors and chronic respiratory conditions, especially asthma, in the context of an unprecedented economic growth in Chile. The cohort was a representative sample of 1232 participants born between 1974 and 1978 in the hospital of Limache. The study includes data collected at birth, during the 1st year of life, at 22 to 28 years (collected between 2000 and 2002) and at 32 to 38 years (collected between 2010 and 2012). The data collected include anthropometric measurements at birth, 1st year of life an...
Source: International Journal of Epidemiology - August 4, 2014 Category: Epidemiology Authors: Amigo, H., Bustos, P., Zumelzu, E., Rona, R. J. Tags: Cohort Profiles Source Type: research

FOXF1 Transcription Factor Is Required for Formation of Embryonic Vasculature by Regulating VEGF Signaling in Endothelial Cells.
Conclusions: FOXF1 is required for formation of embryonic vasculature by regulating endothelial genes critical for vascular development and VEGF signaling. PMID: 25091710 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - August 4, 2014 Category: Cardiology Authors: Ren X, Ustiyan V, Pradhan A, Cai Y, Havrilak JA, Bolte CS, Shannon JM, Kalin TV, Kalinichenko VV Tags: Circ Res Source Type: research

Capsaicin cough threshold test in diagnostics
Among patients with chronic unexplained cough, there is a recognized subgroup with respiratory symptoms induced by environmental irritants like chemicals and odours. The diagnosis of sensory hyperreactivity (SHR) has been suggested for this group of patients and can be made using a tidal breathing capsaicin inhalation test. The aim of the present study was to evaluate the ability of a single-breath, dose-response capsaicin threshold test to discriminate such patients from control subjects. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 4, 2014 Category: Respiratory Medicine Authors: Teet Pullerits, Ewa Ternesten-Hasséus, Ewa-Lena Johansson, Eva Millqvist Source Type: research

Pooled safety analysis of the fixed-dose combination of indacaterol and glycopyrronium, its monocomponents, and tiotropium versus placebo in COPD patients
To further assess the safety profile of the fixed-dose combination of indacaterol and glycopyrronium (QVA149) and its monocomponents; we investigated the impact of individual patient-level factors and time by integrating the patient-level safety data from the QVA149 clinical programme with relevant information from the independent indacaterol and glycopyrronium safety databases. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - August 4, 2014 Category: Respiratory Medicine Authors: Jadwiga A. Wedzicha, Ronald Dahl, Roland Buhl, Agnes Schubert-Tennigkeit, Hungta Chen, Peter D’Andrea, Robert Fogel, Donald Banerji Source Type: research

Agmatine-containing poly(amidoamine)s as novel class of antiviral macromolecules: structural properties and in vitro evaluation of infectivity inhibition.
Abstract Poly(amidoamine)s (PAAs) are multifunctional tert-amine polymers endowed with high structural versatility. Here we report on the screening of a minilibrary of PAAs against a panel of viruses. The PAA AGMA1 showed antiviral activity against herpes simplex virus, human cytomegalovirus, human papillomavirus-16, and respiratory syncytial virus, but not against human rotavirus and vesicular stomatitis virus. The results suggest the contribution of both polycationic nature and side guanidine groups in imparting antiviral activity. PMID: 25092704 [PubMed - as supplied by publisher] (Source: Herpes)
Source: Herpes - August 4, 2014 Category: Infectious Diseases Authors: Donalisio M, Ranucci E, Cagno V, Civra A, Manfredi A, Cavalli R, Ferruti P, Lembo D Tags: Antimicrob Agents Chemother Source Type: research

New Therapeutic Targets in Idiopathic Pulmonary Fibrosis: Aiming to Rein in Runaway Wound Healing Responses.
Abstract Idiopathic pulmonary fibrosis (IPF) is a devastating disease, with a median survival as short as 3 years from the time of diagnosis, and no pharmacological therapies yet approved by the US Food and Drug Administration (FDA). To address the great unmet need for effective IPF therapy, a number of new drugs have recently been, or are now being, evaluated in clinical trials. The rationales for most of these therapeutic candidates are based on the current paradigm of IPF pathogenesis, in which recurrent injury to the alveolar epithelium is thought to drive aberrant wound healing responses, resulting in fibrosis...
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2014 Category: Respiratory Medicine Authors: Ahluwalia N, Shea BS, Tager AM Tags: Am J Respir Crit Care Med Source Type: research

A Functional Synonymous Coding Variant in the IL1RN Gene Associates with Survival in Septic Shock.
Conclusions: In European ancestry subjects, the IL1RN variant rs315952C is preferentially transcribed, associates with increased evoked plasma IL1RA, and with improved survival from septic shock. It may be that genetically determined IL1RA levels influence survival from septic shock. PMID: 25089931 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - August 4, 2014 Category: Respiratory Medicine Authors: Meyer NJ, Ferguson JF, Feng R, Wang F, Patel PN, Li M, Xue C, Qu L, Liu Y, Boyd JH, Russell JA, Christie JD, Walley KR, Reilly MP Tags: Am J Respir Crit Care Med Source Type: research