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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Short‐length ligamentum arteriosum as a cause of congenital narrowing of the left main stem bronchus
Summary An entity that has received little attention as cause or recurrent respiratory disorder is the narrowing of the left main stem bronchus. When not associated with congenital heart disorders, this condition has been ascribed to primary localized malacia of the bronchial cartilages or to the anterior displacement of the descending aorta in front to the adjacent vertebral bodies. Four girls were evaluated for recurrent/chronic respiratory symptoms. A pulsatile extrinsic compression on the posterior bronchial wall of the left main stem bronchus was detected, pressed between the descending aorta, posteriorly, and the lef...
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Oliviero Sacco, Francesco Santoro, Elena Ribera, Gian Michele Magnano, Giovanni A. Rossi Tags: Original Article: Other Source Type: research

Caution to use bronchoscopic CO2 cryotherapy for foreign body removal in children
(Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Jürg Hammer, Daniel Trachsel, Thomas Nicolai, Markus Weiss, Ernst Eber Tags: Letter to the Editor Source Type: research

PELICAN: Content evaluation of patient‐centered care for children with asthma based on an online tool
ConclusionImplementation of patient‐centered care based on the Pelican instrument is recommended in specialized care, although more extensive training of nurses in PCC will improve the successful execution of the evaluated treatment. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Stephanie van Bragt, Lisette van den Bemt, Riet Cretier, Chris van Weel, Peter Merkus, Tjard Schermer Tags: Original Article: Asthma Source Type: research

Respiratory impedance in patients with Duchenne muscular dystrophy
Conclusion: This study showed that IOS is feasible in children and adolescents with DMD and yields information about respiratory function not achievable with the usual forced techniques. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Laura Gochicoa‐Rangel, Mario H. Vargas, José Luis Alonso‐Gómez, Luis Rodríguez‐Moreno, David Martínez‐Briseño, Omar Baños‐Mejía, Luis Torre‐Bouscoulet Tags: Original Article Source Type: research

Influence of graft ischemic time on survival in children with cystic fibrosis after lung transplantation
ConclusionsIschemic time of 4–6 hr was associated with the highest long‐term survival in first‐time pediatric LTx recipients with CF, with ischemic time <4 hr related to diminished survival. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Don Hayes, Dmitry Tumin, Benjamin T. Kopp, Joseph D. Tobias, Shahid I. Sheikh, Stephen E. Kirkby Tags: Original Article: Cystic Fibrosis Source Type: research

Anti‐coagulant therapy with dabigatran for cystic fibrosis patients
We describe our experience in successfully using dabigatran for long‐term anti‐coagulation therapy in two CF patients. Our experience suggests that dabigatran can serve as an option for anticoagulation therapy in CF. Pediatr Pulmonol. © 2016 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - April 29, 2016 Category: Respiratory Medicine Authors: Manvi Bansal, Clement L. Ren Tags: Case Report Source Type: research

Potassium-promoted Binding of Copper to ApoFet3p [Metabolism]
Acquisition and distribution of metal ions support a number of biological processes. Here we show that respiratory growth of and iron acquisition by the yeast Saccharomyces cerevisiae relies on potassium (K+) compartmentalization to the trans-Golgi network via Kha1p, a K+/H+ exchanger. K+ in the trans-Golgi network facilitates binding of copper to the Fet3p multi-copper ferroxidase. The effect of K+ is not dependent on stable binding with Fet3p or alteration of the characteristics of the secretory pathway. The data suggest that K+ acts as a chemical factor in Fet3p maturation, a role similar to that of cations in folding o...
Source: Journal of Biological Chemistry - April 29, 2016 Category: Chemistry Authors: Wu, X., Kim, H., Seravalli, J., Barycki, J. J., Hart, P. J., Gohara, D. W., Di Cera, E., Jung, W. H., Kosman, D. J., Lee, J. Tags: Cell Biology Source Type: research

Human Parechovirus 1 Infection Occurs via αVβ1 Integrin
In conclusion, our results demonstrate that in some cell lines the cellular entry of HPeV-1 is primarily mediated by the active form of αVβ1 integrin without visible receptor clustering. (Source: PLoS One)
Source: PLoS One - April 29, 2016 Category: Biomedical Science Authors: Pirjo Merilahti Source Type: research

Surgical factors and complications affecting hospital outcome in redo mitral surgery: insights from a multicentre experience [ADULT CARDIAC]
CONCLUSIONS ReMVS still carries the risk of significant early mortality and major morbidity. Major lesion to cardiovascular structures is the most dreadful iatrogenic complication, and injury of a previous LIMA graft identifies patients at higher risk of operative mortality. Prolonged cross-clamp times, extracellular crystalloid cardioplegia and massive transfusions have profound impact on early outcome, as well as the development of perioperative AMI, eventually requiring IABP and prolonged intubation. The combination of antegrade and retrograde cardioplegia seems to offer a better myocardial protection in these high-risk...
Source: European Journal of Cardio-Thoracic Surgery - April 29, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Onorati, F., Perrotti, A., Reichart, D., Mariscalco, G., Della Ratta, E., Santarpino, G., Salsano, A., Rubino, A., Biancari, F., Gatti, G., Beghi, C., De Feo, M., Mignosa, C., Pappalardo, A., Fischlein, T., Chocron, S., Detter, C., Santini, F., Faggian, G Tags: Basic research vascular ADULT CARDIAC Source Type: research

Postoperative inspiratory muscle training in addition to breathing exercises and early mobilization improves oxygenation in high-risk patients after lung cancer surgery: a randomized controlled trial [THORACIC]
CONCLUSIONS Two weeks of additional postoperative IMT, compared with standard physiotherapy alone, did not preserve respiratory muscle strength but improved oxygenation in high-risk patients after lung cancer surgery. Respiratory muscle strength recovered in both groups 2 weeks after surgery. CLINICAL TRIALS.GOV ID NCT01793155. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - April 29, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Brocki, B. C., Andreasen, J. J., Langer, D., Souza, D. S. R., Westerdahl, E. Tags: Mediastinum THORACIC Source Type: research

Comparison of volume-controlled ventilation and pressure-controlled ventilation volume guaranteed during laparoscopic surgery in Trendelenburg position
To analyze the effects of pressure-controlled ventilation-volume guaranteed (PCV-VG) and volume controlled ventilation (VCV) on airway pressures and respiratory and circulatory indicators during laparoscopic surgery in Trendelenburg position. (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - April 29, 2016 Category: Anesthesiology Authors: Osama M. Assad, Ayman A. El sayed, Mohamed A. Khalil Tags: Original contribution Source Type: research

Specific and Non‐specific Clinical Presentations in the Year Before the Diagnosis of Childhood Leukaemia
ConclusionsWe described a clinical picture in the year before leukaemia diagnosis. These findings revealed ongoing difficulties in early diagnosis of childhood leukaemia in healthcare settings. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - April 29, 2016 Category: Cancer & Oncology Authors: TienYu Owen Yang, Yen‐Lin Liu, Wan‐Ting Huang, Mei‐Huei Chen, Pau‐Chung Chen Tags: Research Article Source Type: research

Is the lack of respiratory gating prejudicial for left breast TomoDirect treatments?
Breast cancer is the most common women cancer, with an incidence rate of over one million cases per year worldwide [1]. Radiation therapy has a major role in the management of this disease, to reduce local recurrence and improve overall survival probability [2]. This treatment modality has long been suspected of causing cardiac toxicities, especially for left breast cases. These toxicities were confirmed notably by a large follow-up work conducted by Darby et al. over 2158 patients [3], which showed that the risk of coronary events would increase by 7.4% per gray delivered to the heart, even if the possibility of a thresho...
Source: Physica Medica: European Journal of Medical Physics - April 29, 2016 Category: Journals (General) Authors: Philippe Meyer, Claudine Niederst, Maximilien Scius, Delphine Jarnet, Nicolas Dehaynin, Matthieu Gantier, Waisse Waissi, Nicolas Poulin, Diran Karamanoukian Tags: Original paper Source Type: research

Convex probe EBUS for centrally located parenchymal lesions without a bronchus sign
Convex probe endobronchial ultrasound (CP-EBUS) has proven safe and accurate for identifying malignancy and granulomatous disease affecting the mediastinum and hilum. For the diagnosis of parenchymal lung lesions, conventional techniques such as transbronchial biopsy, brush and lavage are useful, particularly when an airway leads directly to the lesion. For centrally located intraparenchymal lesions, CP-EBUS has been shown to be efficacious. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - April 29, 2016 Category: Respiratory Medicine Authors: A. Christine Argento, Jonathan Puchalski Source Type: research

Probability of IV antibiotic retreatment within thirty days is associated with duration and location of IV antibiotic treatment for pulmonary exacerbation in cystic fibrosis
There are few objective data to guide management of cystic fibrosis (CF) pulmonary exacerbations. We studied intravenous (IV) antibiotic treatment failure as defined by a need to retreat patients with IV antibiotics within 30days of completion of a prior IV antibiotic treatment for pulmonary exacerbation. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 29, 2016 Category: Respiratory Medicine Authors: D.R. VanDevanter, P.A. Flume, N. Morris, M.W. Konstan Tags: Original Article Source Type: research

Variation of glucose tolerance in adult patients with cystic fibrosis: What is the potential contribution of insulin sensitivity?
Reduced insulin secretion is a key factor to explain high prevalence of glucose intolerance in patients with cystic fibrosis (CF). However, the role of insulin sensitivity remains unclear. The aim of this study is to investigate the association of insulin secretion and sensitivity with the evolution of glucose tolerance. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - April 29, 2016 Category: Respiratory Medicine Authors: Valérie Boudreau, Adèle Coriati, Imane Hammana, Sophie Ziai, Katherine Desjardins, Yves Berthiaume, Rémi Rabasa-Lhoret Tags: Original Article Source Type: research

A systematic review comparing laparoscopic versus open adhesiolysis in patients with adhesional small bowel obstruction
Conclusion Laparoscopic adhesiolysis for ASBO seems to have clinically proven advantage over open approach Teaser Current systematic review of 14 comparative studies on 38057 patients indicates that the laparoscopic adhesiolysis for adhesional small bowel obstruction improves post-operative clinical outcomes with reduced post-operative morbidity and mortality. Laparoscopic adhesiolysis may safely be performed in patients with adhesional bowel obstruction in whom the procedure is deemed feasible. (Source: The American Journal of Surgery)
Source: The American Journal of Surgery - April 29, 2016 Category: Surgery Source Type: research

Clinical spectrum of the Middle East respiratory syndrome coronavirus (MERS-CoV)
Middle East respiratory syndrome coronavirus (MERS-CoV) was first recognized as a cause of severe acute respiratory infection in the Kingdom of Saudi Arabia in 2012. As of February 2, 2016, 1638 laboratory-confirmed cases have been reported to the World Health Organization, including at least 587 deaths [1]. While MERS-CoV has affected 26 countries, the majority of cases have been reported in the Middle East [2]. Transmission has most commonly been associated with nosocomial outbreaks [3–7] and is occasionally due to animal-to-human (most commonly camel-to-human) transmission and sporadic human-to-human transmission in t...
Source: Journal of Infection and Public Health - April 29, 2016 Category: Global & Universal Authors: Mikiko Senga, Yaseen M. Arabi, Robert A. Fowler Source Type: research

A Comparative Study of Lung Host Defense in Murine Obesity Models: Insights Into Neutrophil Function.
CONCLUSIONS: Obesity-associated impairment of host response to lung infection is characterized by defects in neutrophil recruitment and survival. Yet, critical differences exist between commonly used mouse models of obesity, and may reflect variable penetrance of elements of the metabolic syndrome as well as other factors. PMID: 27128821 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory Cell and Molecular Biology)
Source: American Journal of Respiratory Cell and Molecular Biology - April 29, 2016 Category: Molecular Biology Authors: Ubags ND, Burg E, Antkowiak M, Wallace AM, Dilli E, Bement J, Wargo MJ, Poynter ME, Wouters EF, Suratt BT Tags: Am J Respir Cell Mol Biol Source Type: research

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the in vitro and in vivo Models of ARDS
Abstract Mesenchymal stromal cells (MSC) have been reported to improve bacterial clearance in preclinical models of Acute Respiratory Distress Syndrome (ARDS) and sepsis. The mechanism of this effect is not fully elucidated yet. The primary objective of this study was to investigate the hypothesis that the antimicrobial effect of MSC in vivo depends on their modulation of macrophage phagocytic activity which occurs through mitochondrial transfer. We established that selective depletion of alveolar macrophages (AM) with intranasal (IN) administration of liposomal clodronate resulted in complete abrogation of MSC antimicrobi...
Source: Stem Cells - April 29, 2016 Category: Stem Cells Authors: Megan V Jackson, Thomas J Morrison, Declan F Doherty, Daniel F McAuley, Michael A Matthay, Adrien Kissenpfennig, Cecilia M O'Kane, Anna D Krasnodembskaya Tags: Translational and Clinical Research Source Type: research

Influenza virus intracellular replication dynamics, release kinetics, and particle morphology during propagation in MDCK cells.
Abstract Influenza viruses are respiratory pathogens and can cause severe disease. The best protection against influenza is provided by annual vaccination. These vaccines are produced in embryonated chicken eggs or using continuous animal cell lines. The latter processes are more flexible and scalable to meet the growing global demand. However, virus production in cell cultures is more expensive. Hence, further research is needed to make these processes more cost-effective and robust. We studied influenza virus replication dynamics to identify factors that limit the virus yield in adherent Madin-Darby canine kidney...
Source: Applied Microbiology and Biotechnology - April 29, 2016 Category: Microbiology Authors: Frensing T, Kupke SY, Bachmann M, Fritzsche S, Gallo-Ramirez LE, Reichl U Tags: Appl Microbiol Biotechnol Source Type: research

Ventromedial hypothalamic melanocortin receptor activation: Regulation of activity energy expenditure and skeletal muscle thermogenesis.
This article is protected by copyright. All rights reserved. PMID: 27126579 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - April 29, 2016 Category: Physiology Authors: Gavini CK, Jones WC, Novak CM Tags: J Physiol Source Type: research

Circulating nucleosomes are associated with mortality in pediatric acute respiratory distress syndrome.
In conclusion, plasma nucleosome levels in early PARDS were associated with increased mortality, correlated with number of non-pulmonary organ failures, and preceded worsening oxygenation. The potential utility of this biomarker for prognostication, risk stratification, and mechanistic insight should be investigated further. PMID: 27130528 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Lung Cellular and Molecular Physiology)
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - April 29, 2016 Category: Cytology Authors: Yehya N, Thomas NJ, Margulies SS Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Potential exposure routes and accumulation kinetics for poly- and perfluorinated alkyl compounds for a freshwater amphipod: Gammarus spp. (Crustacea).
Abstract Gammarids were exposed to sediments from a deposition site located on the Rhône River (France) downstream of a fluoropolymer manufacturing plant. Gammarids accumulated to various extents four long-chain perfluoroalkyl carboxylic acids (PFCAs) from C9 to C13, one sulfonate, perfluorooctane sulfonate (PFOS) and three of its precursors (the perflurooctane sulfonamide (FOSA), the N-methyl perfluorooctane sulfonamidoacetic acid (MeFOSAA), the N-ethyl perfluorooctane sulfonamidoacetic acid (EtFOSAA) and the 6:2 fluorotelomer sulfonic acid (6:2 FTSA). Whatever the compound, the steady state was not achieved afte...
Source: Chemosphere - April 29, 2016 Category: Chemistry Authors: Bertin D, Labadie P, Ferrari BJ, Sapin A, Garric J, Geffard O, Budzinski H, Babut M Tags: Chemosphere Source Type: research

The enlightenments from ITMIG Consensus on WHO histological classification of thymoma and thymic carcinoma: refined definitions, histological criteria, and reporting.
Authors: Wu J, Fang W, Chen G Abstract The World Health Organization (WHO) histological classification of the thymoma and thymic carcinoma (TC) has been criticized for poor interobserver reproducibility or inconsistencies in the routine pathological diagnosis. The International Thymic Malignancy Interest Group (ITMIG) panel achieved an agreement to maintain the widely accepted WHO framework but to refine historic definitions and histological criteria, and further introduce some new terms with the aim to improve interobserver reproducibility. This review addresses the enlightenments we can get from the ITMIG consens...
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Comparison of the Masaoka-Koga staging and the International Association for the Study of Lung Cancer/the International Thymic Malignancies Interest Group proposal for the TNM staging systems based on the Chinese Alliance for Research in Thymomas retrospective database.
CONCLUSIONS: Compared with Masaoka-Koga staging, the IASLC/ITMIG TNM staging proposal not only describes the extent of tumor invasion but also provides information on lymphatic involvement and tumor dissemination. Further study using prospectively recorded information on the proposed TNM categories would be helpful to better grouping thymic tumors for predicting prognosis and guiding clinical management. PMID: 27114841 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Clinicopathological analysis of 241 thymic epithelial tumors-experience in the Shanghai Chest Hospital from 1997-2004.
CONCLUSIONS: WHO histological subtype, Masaoka stage and (neo-)adjuvant treatment have remained independent determinants of OS in patients with thymomas and TCs. Compared with the historical cohort during 1969-1996, prognosis of patients with B2, B3 thymomas has improved, which may be partly due to the increased use of adjuvant therapies. Prognosis of patients with TCs remained unsatisfactory, suggesting that neoadjuvant treatment should be tested to improve survival. PMID: 27114840 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Postoperative survival for patients with thymoma complicating myasthenia gravis-preliminary retrospective results of the ChART database.
CONCLUSIONS: Although MG is not an independent prognostic factor, the survival of patients with thymoma was superior when MG was present, especially in late Masaoka stage patients. Possible reasons included early diagnosis of the tumor, better histologic types, an overall higher R0 resection and less recurrence. PMID: 27114839 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Outcome of nonsurgical treatment for locally advanced thymic tumors.
CONCLUSIONS: When used to treat locally advanced thymic tumors unsuitable for surgery, CCRT performed more favorably than RT alone or SCRT in both tumor response and long time survival, but probably with the increasing risk of pulmonary damage. CCRT may offer the best chance of disease control in the management of locally advanced disease. PMID: 27114838 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The application of postoperative chemotherapy in thymic tumors and its prognostic effect.
CONCLUSIONS: Pathologically higher grade histology, incomplete resection, and postoperative radiotherapy were found to be associated with worse outcomes in advanced stage thymic tumors. At present, there is no evidence to show that postoperative chemotherapy may help improve prognosis in patients with Masaoka-Koga stage III and IV thymic tumors. PMID: 27114837 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

The role of postoperative radiotherapy for stage I/II/III thymic tumor-results of the ChART retrospective database.
CONCLUSIONS: The current retrospective study indicates that PORT after incomplete resection could improve OS and DFS for patients with stage I to III thymic tumors. However for those after complete resection, PORT does not seem to have any survival benefit on the whole. PMID: 27114836 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis.
CONCLUSIONS: Thymectomy, instead of tumor resection alone, should still be recommended as the surgical standard for thymic malignancies, especially for stage II tumors and those with concomitant MG. PMID: 27114835 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Perioperative outcomes and long-term survival in clinically early-stage thymic malignancies: video-assisted thoracoscopic thymectomy versus open approaches.
CONCLUSIONS: This study suggests that VATS thymectomy is an effective approach for clinically early-stage thymic malignancies. And it may offer better perioperative outcomes, as well as equal oncological survival. PMID: 27114834 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Preoperative induction therapy for locally advanced thymic tumors: a retrospective analysis using the ChART database.
CONCLUSIONS: Preoperative neoadjuvant therapy have been used only occasionally in locally advanced thymic malignances. Effective induction therapy leading to tumor downstaging may be beneficial for potentially unresectable diseases, especially in patients with thymomas. These findings would be helpful to related studies in the future. PMID: 27114833 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Pretreatment biopsy for histological diagnosis and induction therapy in thymic tumors.
CONCLUSIONS: It is crucial to get histological diagnosis for thymoma before surgery or adjuvant treatment and minimally invasive biopsy should be undertaken. Although in our study we could not find the benefit of induction chemotherapy before surgery in survival and recurrence rate, it could increase the R0 resection rate compared with direct surgery in late stage (III and IVa). PMID: 27114832 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

CT staging and preoperative assessment of resectability for thymic epithelial tumors.
CONCLUSIONS: Clinical staging of TET could be accurately evaluated with CT features including tumor shape, contour, enhancement pattern, with or without invasion of adjacent structures, and presence of pleural, pericardial effusion or intrapulmonary metastasis. Absence of arterial system invasion on CT was the only predictive feature for predicting complete resection of TET. PMID: 27114831 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Management of thymic tumors-consensus based on the Chinese Alliance for Research in Thymomas Multi-institutional retrospective studies.
Authors: Fang W, Fu J, Shen Y, Wei Y, Tan L, Zhang P, Han Y, Chen C, Zhang R, Li Y, Chen K, Chen H, Liu Y, Cui Y, Wang Y, Pang L, Yu Z, Zhou X, Liu Y, Chen G, Members of the Chinese Alliance for Research in Thymomas PMID: 27114830 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

Journal of Thoracic Disease Focused Issue: Management of Thymoma.
Authors: Korst RJ PMID: 27114829 [PubMed] (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - April 28, 2016 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research

An 85-year-old woman with respiratory failure and positional hypoxemia
AN 85-YEAR-OLD WOMAN WAS BROUGHT to our intensive care unit because of worsening hypoxemia over the past day. About 3 weeks earlier she had been diagnosed with acute bilateral pulmonary emboli in the... (Source: Cleveland Clinic Journal of Medicine)
Source: Cleveland Clinic Journal of Medicine - April 28, 2016 Category: Journals (General) Tags: CCJM Cardiovascular Board Review CCJM CME CCJM Slide-Out CCJM Cardiology CCJM Emergency Medicine CCJM Geriatrics CCJM Pulmonary CCJM Home Page Slider Source Type: research

Treatment and monitoring of hypersensitivity pneumonitis.
Authors: Miyazaki Y, Tsutsui T, Inase N Abstract Hypersensitivity pneumonitis (HP) is an immunologically induced lung disease that develops after inhalation of certain environmental antigens only in subjects with susceptibility to antigens. Therefore, both environmental and host immunological factors play important roles in the aetiology and pathogenesis of HP. Determination of an inciting antigen is crucial for diagnosis, treatment and monitoring. For treatment, modification of the environment and of the host immune response are important. The former includes reduction of antigenic burden (i.e. disinfectant, clean...
Source: Expert Review of Clinical Immunology - April 28, 2016 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Poor agreement between diagnostic tests for latent tuberculosis infection among HIV‐infected persons in Hong Kong
ConclusionMajor discordance in positive results, high reversion rates and low tuberculosis incidence among test‐positive subjects cast serious doubt on the utility of the currently available LTBI tests in the annual screening of HIV‐infected persons in an intermediate tuberculosis burden area. (Source: Respirology)
Source: Respirology - April 28, 2016 Category: Respiratory Medicine Authors: Chi Chiu Leung, Kenny Chan, Wing Cheong Yam, Man Po Lee, Chi Kuen Chan, Ka Hing Wong, Pak Leung Ho, Ida Mak, Cheuk Ming Tam Tags: Original Article Source Type: research

Changes in heart rate variability during vasomotor symptoms among midlife women
This study tested whether acute decreases in cardiac vagal control would occur with VMS in a large sample of women monitored during wake and sleep. Methods: Two hundred and fifteen nonsmoking women aged 40 to 60 years with evidence of VMS were included. Women were free of a history of clinical cardiovascular disease or arrhythmia; or use of insulin, beta blockers, calcium channel blockers, or medications impacting VMS. Women underwent 24 hours of ambulatory monitoring for physiological (sternal skin conductance) and self-report (electronic diary) measurement of VMS; heart rate variability (electrocardiogram); and respir...
Source: Menopause - April 28, 2016 Category: OBGYN Tags: Original Articles Source Type: research

A Novel Drug Delivery System for the Human Nasal Epithelium.
Authors: Takano K, Kojima T, Keira T, Miyata R, Nomura K, Kakuki T, Kaneko Y, Yajima R, Kakiuchi A, Himi T Abstract The epithelium of upper respiratory tissues such as the human nasal mucosa forms a continuous barrier via tight junctions (TJs). The development of a drug delivery system for use across the nasal mucosa is being reconsidered. In intranasal administration across the nasal mucosa, the paracellular pathway regulated by TJs is extremely important. It is known that the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) binds the TJ protein claudin and disrupts the tight junctional barrier w...
Source: Advances in Oto-Rhino-Laryngology - April 28, 2016 Category: ENT & OMF Tags: Adv Otorhinolaryngol Source Type: research

Current evidence for the effectiveness of heated and humidified high flow nasal cannula supportive therapy in adult patients with respiratory failure
High flow nasal cannula (HFNC) supportive therapy has emerged as a safe, useful therapy in patients with respiratory failure, improving oxygenation and comfort. Recently several clinical trials have analyzed t... (Source: Critical Care)
Source: Critical Care - April 28, 2016 Category: Intensive Care Authors: Oriol Roca, Gonzalo Hernández, Salvador Díaz-Lobato, José M. Carratalá, Rosa M. Gutiérrez and Joan R. Masclans Source Type: research

Unusual presentation: Concurrent IgA deficiency and idiopathic pulmonary hemosiderosis
Summary Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder that should be considered in the differential diagnosis of patients with hemoptysis, recurrent alveolar hemorrhage, dyspnea and iron deficiency anemia (IDA). The frequent association of autoimmune disorders with IPH and a favorable response to steroids suggest the presence of an underlying immune disorder. Here we present a case of a patient with cough, fever, and cyanosis who was also diagnosed with IPH and concurrent selective immunoglobulin A deficiency. This presentation is a unique presentation because of the co‐occurrence of these two disorders. Pe...
Source: Pediatric Pulmonology - April 28, 2016 Category: Respiratory Medicine Authors: Mustafa Erkoçoğlu, Ersoy Civelek, Can Naci Kocabaş Tags: Case Report Source Type: research

Airway reconstruction: review of an approach to the advanced-stage laryngotracheal stenosis
Conclusion The review of our approach to open airway repair/reconstruction showed its efficacy in advanced-stage laryngotracheal stenosis. Good knowledge of a variety of reconstructive techniques is important to achieve good results in a variety of age groups. (Source: Brazilian Journal of Otorhinolaryngology)
Source: Brazilian Journal of Otorhinolaryngology - April 28, 2016 Category: ENT & OMF Source Type: research

Early mortality in multiple myeloma: the time‐dependent impact of comorbidity: A population‐based study in 621 real‐life patients
Multiple myeloma is a heterogeneous disease with variable survival; this variability cannot be fully explained by the current systems of risk stratification. Early mortality remains a serious obstacle to further improve the trend toward increased survival demonstrated in recent years. However, the definition of early mortality is not standardized yet. Importantly, no study has focused on the impact of comorbidity on early mortality in multiple myeloma to date. Therefore, we analyzed the role of baseline comorbidity in a large population‐based cohort of 621 real‐life myeloma patients over a 31‐year period. To evaluate...
Source: American Journal of Hematology - April 28, 2016 Category: Hematology Authors: Rafael Ríos‐Tamayo, Juan Sáinz, Joaquín Martínez‐López, José Manuel Puerta, Daysi‐Yoe‐Ling Chang, Teresa Rodríguez, Pilar Garrido, José Luís García de Veas, Antonio Romero, Lucía Moratalla, Elisa López‐Fernández, Pedro Antonio Gonz Tags: Research Article Source Type: research