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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

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(Source: Tobacco Control)
Source: Tobacco Control - October 15, 2014 Category: Respiratory Medicine Tags: PostScript Source Type: research

Heavy metal hazards of Nigerian smokeless tobacco
Conclusions Although there was no apparent risk when each metal was analysed and considered individually, the potential risk could be multiplied when considering all heavy metals. The high heavy metal content in Nigerian smokeless tobacco may have public health implications. (Source: Tobacco Control)
Source: Tobacco Control - October 15, 2014 Category: Respiratory Medicine Authors: Orisakwe, O. E., Igweze, Z. N., Okolo, K. O., Ajaezi, G. C. Tags: Research paper Source Type: research

Tobacco control in Namibia: the importance of government capacity, media coverage and industry interference
Conclusions The fact that Namibia was able to pass fairly comprehensive tobacco control legislation with such meagre resources is commendable. The government must now implement the regulations that make the legislation effective. Tobacco control progress in low-income and middle-income nations can be encouraged through use of the media and improved staff and legal capacity within health ministries. (Source: Tobacco Control)
Source: Tobacco Control - October 15, 2014 Category: Respiratory Medicine Authors: Tam, J., van Walbeek, C. Tags: Research paper Source Type: research

Does use of 'non-trial' cessation support help explain the lack of effect from offering NRT to quitline callers in a RCT?
Introduction Quitlines help smokers to stop but few studies have explored how behavioural and medicinal interventions can be optimally delivered via this route.1 One of these was the PORTSSS trial, which found that offering free nicotine replacement therapy (NRT) vouchers did not increase cessation rates compared with no offer.2 It also found that a ‘proactive’, more intensive call regime from/to clients did not improve cessation rates over ‘usual care’. Was it possible that participants who did not receive a voucher for NRT sought out and used other forms of cessation support, which minimised any e...
Source: Tobacco Control - October 15, 2014 Category: Respiratory Medicine Authors: Docherty, G., Lewis, S., McEwen, A., Bauld, L., Coleman, T. Tags: Open access Research letter Source Type: research

Which smoking cessation aids are proven effective according to smokers who want to quit smoking? A report from the Netherlands
This study sought to find an answer to this question. The data collected in September 2010 were part of a study administered by the research agency MarketResponse. Adult smokers... (Source: Tobacco Control)
Source: Tobacco Control - October 15, 2014 Category: Respiratory Medicine Authors: Willems, R. A., Willemsen, M. C., Smit, E. S., Nagelhout, G. E., Janssen, E., de Vries, H. Tags: Research letter Source Type: research

Application of clinical proteomics in acute respiratory distress syndrome
This article reviews the contemporary proteomics platforms that are available for comprehensive studies in ARDS. The challenges of various biofluids that could be investigated and some of the studies performed are also discussed. (Source: Clinical and Translational Medicine)
Source: Clinical and Translational Medicine - October 15, 2014 Category: Internal Medicine Authors: Maneesh BhargavaLeeAnn HigginsChristine WendtDavid Ingbar Source Type: research

Bench-test comparison of 26 emergency and transport ventilators
Conclusion: Major differences were observed between devices and categories, either in terms of general characteristics or technical reliability, across the spectrum of operation. Huge variability of tidal volume delivery with some devices in response to modifications in respiratory mechanics and FIO2 should make clinicians question their use in the clinical setting. (Source: Critical Care)
Source: Critical Care - October 15, 2014 Category: Intensive Care Authors: Erwan L¿HerAnnie RoyNicolas Marjanovic Source Type: research

Year in review 2013: Critical Care - respirology
This review documents important progress made in 2013 in the field of critical care respirology, in particular with regard to acute respiratory failure and acute respiratory distress syndrome. Twenty-five original articles published in the respirology and critical care sections of Critical Care are discussed in the following categories: pre-clinical studies, protective lung ventilation – how low can we go, non-invasive ventilation for respiratory failure, diagnosis and prognosis in acute respiratory distress syndrome and respiratory failure, and promising interventions for acute respiratory distress syndrome. (Source: Critical Care)
Source: Critical Care - October 15, 2014 Category: Intensive Care Authors: Gerard CurleyArthur Slutsky Source Type: research

Dietary milk fat globule membrane improves endurance capacity in mice
Milk fat globule membrane (MFGM) comprises carbohydrates, membrane-specific proteins, glycoproteins, phospholipids, and sphingolipids. We evaluated the effects of MFGM consumption over a 12-wk period on endurance capacity and energy metabolism in BALB/c mice. Long-term MFGM intake combined with regular exercise improved endurance capacity, as evidenced by swimming time until fatigue, in a dose-dependent manner. The effect of dietary MFGM plus exercise was accompanied by higher oxygen consumption and lower respiratory quotient, as determined by indirect calorimetry. MFGM intake combined with exercise increased plasma levels...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 15, 2014 Category: Physiology Authors: Haramizu, S., Ota, N., Otsuka, A., Hashizume, K., Sugita, S., Hase, T., Murase, T., Shimotoyodome, A. Tags: Obesity, Diabetes and Energy Homeostasis Source Type: research

Disinhibition of the midbrain colliculi unmasks coordinated autonomic, respiratory, and somatomotor responses to auditory and visual stimuli
In this study, we tested the hypothesis that, under conditions in which collicular neurons are disinhibited, coordinated cardiovascular, somatomotor, and respiratory responses can be evoked by natural environmental stimuli. In response to natural auditory, visual, or somatosensory stimuli, powerful synchronized increases in sympathetic, respiratory, and somatomotor activity were generated following blockade of GABAA receptors in a specific region in the midbrain colliculi of anesthetized rats, but not under control conditions. Such responses still occurred after removal of most of the forebrain, including the amygdala and ...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 15, 2014 Category: Physiology Authors: Muller-Ribeiro, F. C. F., Dampney, R. A. L., McMullan, S., Fontes, M. A. P., Goodchild, A. K. Tags: Respiration Source Type: research

Physiological responses of a rodent to heliox reveal constancy of evaporative water loss under perturbing environmental conditions
We present here evidence, based on the first measurements of evaporative water loss for a small mammal in heliox, that mammals may have a previously unappreciated ability to maintain acute constancy of total evaporative water loss under perturbing environmental conditions. Thermoregulatory responses of ash-grey mice (Pseudomys albocinereus) to heliox were as expected, with changes in metabolic rate, conductance, and respiratory ventilation consistent with maintaining constancy of body temperature under conditions of enhanced heat loss. However, evaporative water loss did not increase in heliox. This is despite our confirma...
Source: AJP: Regulatory, Integrative and Comparative Physiology - October 15, 2014 Category: Physiology Authors: Cooper, C. E., Withers, P. C. Tags: Fluid and Electrolyte Homeostasis Source Type: research

Whooping cough.
Abstract Whooping cough or pertussis is a contagious disease of the upper respiratory tract caused by the bacterium Bordetella pertussis. Whooping cough is transmitted via droplets in the air from sneezing or coughing and individuals are considered infectious from just before and up to 21 days after the onset of the cough. Usually it has an incubation period of seven to ten days, and the disease lasts six to eight weeks. PMID: 25315570 [PubMed - in process] (Source: Nursing Standard)
Source: Nursing Standard - October 15, 2014 Category: Nursing Authors: Chivima B Tags: Nurs Stand Source Type: research

Butorphanol with oxygen insufflation corrects etorphine-induced hypoxaemia in chemically immobilized white rhinoceros ( Ceratotherium simum )
Background: Opioid-induced immobilization is associated with severe respiratory depression in the white rhinoceros. We evaluated the efficacy of butorphanol and oxygen insufflation in alleviating opioid-induced respiratory depression in eight boma-managed rhinoceros. Results: Chemical immobilization with etorphine, azaperone and hyaluronidase, as per standard procedure for the white rhinoceros, caused severe respiratory depression with hypoxaemia (PaO2?=?27???7?mmHg [mean???SD]), hypercapnia (PaCO2?=?82???6?mmHg) and acidosis (pH =7.26???0.02) in the control trial at 5?min. Compared to pre-intervention values, butorphanol ...
Source: BMC Veterinary Research - October 15, 2014 Category: Veterinary Research Authors: Anna HawMarkus HofmeyrAndrea FullerPeter BussMichele MillerGregory FlemingLeith Meyer Source Type: research

Basal levels of glutathione peroxidase correlate with onset of radiation induced lung disease in inbred mouse strains
In conclusion, pulmonary oxidative stress and antioxidant markers were more affected by inbred strain than radiation over 7 days posttreatment. Lung GPx activity, and GPx2 expression, predicted for survival from lethal pneumonitis, and serum GPx for fibrosis, in this panel of mice. (Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Kunwar, A., Haston, C. K. Tags: CALL FOR PAPERS Source Type: research

In search of the elusive lipofibroblast in human lungs
Although the pulmonary interstitial lipofibroblast (LF) has been widely recognized in rat and mouse lungs, their presence in human lungs remains controversial. In a recent issue of the Journal, Tahedl and associates (Tahedl D, Wirkes A, Tschanz SA, Ochs M, Mühlfeld C. Am J Physiol Lung Cell Mol Physiol 307: L386–L394, 2014) address this controversy and provide the most detailed stereological analysis of LFs in mammals other than rodents. Strikingly, their observations demonstrate that LFs were only observed in rodents, which contrasts with earlier reports. This editorial reviews the anatomical, physiological, an...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Ahlbrecht, K., McGowan, S. E. Tags: EDITORIAL FOCUS Source Type: research

Regulation of epithelial sodium channels in urokinase plasminogen activator deficiency
Epithelial sodium channels (ENaC) govern transepithelial salt and fluid homeostasis. ENaC contributes to polarization, apoptosis, epithelial-mesenchymal transformation, etc. Fibrinolytic proteases play a crucial role in virtually all of these processes and are elaborated by the airway epithelium. We hypothesized that urokinase-like plasminogen activator (uPA) regulates ENaC function in airway epithelial cells and tested that possibility in primary murine tracheal epithelial cells (MTE). Both basal and cAMP-activated Na+ flow through ENaC were significantly reduced in monolayers of uPA-deficient cells. The reduction in ENaC...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Chen, Z., Zhao, R., Zhao, M., Liang, X., Bhattarai, D., Dhiman, R., Shetty, S., Idell, S., Ji, H.-L. Tags: ARTICLES Source Type: research

Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice
Signaling through platelet-derived growth factor receptor-α (PDGFRα) is required for alveolar septation and participates in alveolar regeneration after pneumonectomy. In both adipose tissue and skeletal muscle, bipotent pdgfrα-expressing progenitors expressing delta-like ligand-1 or sex-determining region Y box 9 (Sox9) may differentiate into either lipid storage cells or myofibroblasts. We analyzed markers of mesenchymal progenitors and differentiation in lung fibroblasts (LF) with different levels (absent, low, or high) of pdgfrα gene expression. A larger proportion of pdgfrα-expressing than...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: McGowan, S. E., McCoy, D. M. Tags: ARTICLES Source Type: research

MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix
We examined whether aberrantly low FoxO3a expression is in part due to increased miR-96 levels in IPF fibroblasts on polymerized collagen, thereby causing IPF fibroblasts to maintain their pathological properties. miR-96 expression was upregulated in IPF fibroblasts compared with control fibroblasts when cultured on collagen. In contrast, FoxO3a mRNA levels were reduced in most IPF fibroblasts. However, when miR-96 function was inhibited, FoxO3a mRNA and protein expression were increased, suppressing IPF fibroblast proliferation and promoting their cell death in a dose-dependent fashion. Likewise, FoxO3a and its target pro...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Nho, R. S., Im, J., Ho, Y.-Y., Hergert, P. Tags: ARTICLES Source Type: research

cAMP-dependent protein kinase activation decreases cytokine release in bronchial epithelial cells
Lung injury caused by inhalation of dust from swine-concentrated animal-feeding operations (CAFO) involves the release of inflammatory cytokine interleukin 8 (IL-8), which is mediated by protein kinase C- (PKC-) in airway epithelial cells. Once activated by CAFO dust, PKC- is responsible for slowing cilia beating and reducing cell migration for wound repair. Conversely, the cAMP-dependent protein kinase (PKA) stimulates contrasting effects, such as increased cilia beating and an acceleration of cell migration for wound repair. We hypothesized that a bidirectional mechanism involving PKA and PKC regulates epithelial airway ...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Wyatt, T. A., Poole, J. A., Nordgren, T. M., DeVasure, J. M., Heires, A. J., Bailey, K. L., Romberger, D. J. Tags: ARTICLES Source Type: research

Role of MMP2 and MMP9 in TRPV4-induced lung injury
In this study, we tested the hypothesis that TRPV4 activation provides a Ca2+ source necessary for proteolytic disruption of cell-cell or cell-matrix adhesion by matrix metalloproteinases (MMPs) 2 and 9, thus increasing septal barrier permeability. In our study, C57BL/6 or TRPV4–/– mouse lungs were perfused with varying doses of the TRPV4 agonist GSK-1016790A (Sigma) and then prepared for Western blot. Lung injury, assessed by increases in lung wet-to-dry weight ratios and total protein levels in the bronchoalveolar lavage fluid, was increased in a dose-dependent fashion in TRPV4+/+ but not TRPV4–/–...
Source: AJP: Lung Cellular and Molecular Physiology - October 15, 2014 Category: Respiratory Medicine Authors: Villalta, P. C., Rocic, P., Townsley, M. I. Tags: ARTICLES Source Type: research

Targeting MARCKS Phosphorylation Site Domain in Lung Cancer: Mechanisms and Therapeutic Implications.
Conclusions: These results suggest a key role for MARCKS PSD in cancer disease and provide a unique strategy for inhibiting the activity of MARCKS PSD as a treatment for lung cancer. PMID: 25318062 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Chen CH, Statt S, Chiu CL, Thai P, Arif M, Adler KB, Wu R Tags: Am J Respir Crit Care Med Source Type: research

Non-Invasive Saliva-Based EGFR Gene Mutation Detection in Lung Cancer Patients.
Conclusions: Our data indicate that EFIRM is effective, accurate, rapid, user-friendly, and cost-effective for the detection of EGFR mutations in the saliva of NSCLC patients. We termed this SAliva-Based EGFR (SABER) mutation detection. PMID: 25317990 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Wei F, Lin CC, Joon A, Feng Z, Troche G, Lira ME, Chia D, Mao M, Ho CL, Su WC, Wong DT Tags: Am J Respir Crit Care Med Source Type: research

Heartbeat Evoked Potentials During Sleep and Daytime Behavior in Children with Sleep Disordered Breathing.
Conclusion: Children with SDB displayed reduced HEP amplitude during sleep, which might be indicative of changes in afferent sensory inputs to the brain and/ or signify differences in sensory gating of cardiac-related information in the insular cortex. Adenotonsillectomy appears to reverse this effect. PMID: 25317937 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Immanuel SA, Pamula Y, Kohler M, Martin J, Kennedy D, Nalivaiko E, Saint DA, Baumert M Tags: Am J Respir Crit Care Med Source Type: research

Using Your Metered Dose Inhaler (MDI).
Authors: PMID: 25317475 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Tags: Am J Respir Crit Care Med Source Type: research

Flip-flop lung. An unusual etiology of bronchiectasis.
PMID: 25317474 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Liptzin DR, Fan LL, Stillwell PC, Dannull KA, Fadell MF, Partrick DA, Dishop MK Tags: Am J Respir Crit Care Med Source Type: research

Invasive endobronchial mucormycosis.
PMID: 25317473 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Ferrell BA, Tolle JJ Tags: Am J Respir Crit Care Med Source Type: research

Reply: the respiratory extracorporeal membrane oxygenation survival prediction score: several potential roles in our bedside practice in intensive care.
PMID: 25317472 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Schmidt M, Pilcher D Tags: Am J Respir Crit Care Med Source Type: research

Reply: cumulative radiation exposure to abdominal organs in patients with cystic fibrosis should not be forgotten.
PMID: 25317471 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Kuo W, Ciet P, Tiddens H, Zhang W, Guillerman RP, van Straten M Tags: Am J Respir Crit Care Med Source Type: research

Respite from the RESP Score.
PMID: 25317470 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Senussi MH Tags: Am J Respir Crit Care Med Source Type: research

Cumulative radiation exposure to abdominal organs in patients with cystic fibrosis should not be forgotten.
PMID: 25317469 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Murphy KP, O'Connell OJ, O'Connor OJ, Plant BJ, Maher MM Tags: Am J Respir Crit Care Med Source Type: research

Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of obstructive sleep apnea.
PMID: 25317468 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D Tags: Am J Respir Crit Care Med Source Type: research

Airway Basal stem/progenitor cells have diminished capacity to regenerate airway epithelium in chronic obstructive pulmonary disease.
PMID: 25317467 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Staudt MR, Buro-Auriemma LJ, Walters MS, Salit J, Vincent T, Shaykhiev R, Mezey JG, Tilley AE, Kaner RJ, Ho MW, Crystal RG Tags: Am J Respir Crit Care Med Source Type: research

Bronchial and systemic inflammation in morbidly obese subjects with asthma: a biopsy study.
PMID: 25317466 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: van Huisstede A, Rudolphus A, van Schadewijk A, Cabezas MC, Mannaerts GH, Taube C, Hiemstra PS, Braunstahl GJ Tags: Am J Respir Crit Care Med Source Type: research

Three-Dimensional Modeled Custom-made Noninvasive Positive Pressure Ventilation Masks in an Infant.
PMID: 25317465 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Carroll A, Amirav I, Marchand R, Olmstead D, Logan H, Grosvenor A, Majaesic C, MacLean J, Mandhane PJ Tags: Am J Respir Crit Care Med Source Type: research

Bosentan for Sarcoidosis-associated Pulmonary Hypertension, Age-adjusted D-Dimer Levels in Pulmonary Embolism, and Mean Arterial Blood Pressure Targets in Septic Shock.
PMID: 25317464 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - October 15, 2014 Category: Respiratory Medicine Authors: Alvarez RA, Barbash IJ, Rose JJ Tags: Am J Respir Crit Care Med Source Type: research