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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Primary Care Providers and a System Problem: A qualitative study of clinicians caring for patients with incidental pulmonary nodules.
Conclusion: PCPs often lack systemic resources to optimize patient-centered approaches when discussing incidental pulmonary nodules with patients. With the advent of lung cancer screening, pulmonologists can assist primary care colleagues by providing accurate information to counsel patients, and assisting in managing conversations about the risk of cancer. Pulmonologists should support efforts to implement reliable systems to ensure adherence to follow-up. PMID: 25790082 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Golden SE, Wiener RS, Sullivan D, Ganzini L, Slatore C Tags: Chest Source Type: research

Pulmonologists' reported use of guidelines and shared decision-making in evaluation of pulmonary nodules: a qualitative study.
CONCLUSION: While pulmonologists appear to routinely personalize pulmonary nodule evaluation strategies based on the individual patient's risk-benefit trade-offs, they may not consistently take patient preferences into account during the decision-making process. In the absence of high-quality evidence regarding optimal methods of pulmonary nodule evaluation, physicians should strive to ensure management decisions are consistent with patients' values. PMID: 25789979 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Wiener RS, Slatore CG, Gillespie C, Clark JA Tags: Chest Source Type: research

Using a narrative approach to enhance clinical care for patients with asthma.
Conclusions: The paper closes with the implications of this approach for clinical practice and future research. PMID: 25789925 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Owton H, Allen-Collinson J, Siriwardena AN Tags: Chest Source Type: research

Dedicated severe asthma services improve healthcare utilisation and quality of life.
Conclusions: This is the first time that a prospective study has shown that a systematic assessment at a dedicated severe asthma centre is associated with improved QoL, asthma control, reduced healthcare utilisation and a reduction in oral steroid burden. PMID: 25789861 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Gibeon D, Heaney LG, Brightling CE, Niven R, Mansur A, Chaudhuri R, Bucknall CE, Menzies-Gow A Tags: Chest Source Type: research

Clinical and Billing Review of ECMO.
Abstract Abstract: Extracorporeal membrane oxygenation (ECMO) is a temporary technique for providing life support for cardiac and/or pulmonary dysfunction. The two forms of ECMO veno-arterial (VA) and veno-venous (VV) are used to support cardiopulmonary and pulmonary dysfunction respectively. Historically, ECMO was predominantly used in the neonatal and pediatric populations as early adult studies failed to improve outcomes. Recently, ECMO has become far more common in the adult population due to positive results in recently published case series and clinical trials during the H1N1 pandemic in 2009-2010. Advanc...
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Blum JM, Lynch W, Coopersmith C Tags: Chest Source Type: research

Lymphangioleiomyomatosis and Tuberous Sclerosis Complex in Quebec: Prevalence and Health Care Utilization.
Conclusion: The prevalence of TSC in Quebec is similar to estimates from previously published surveys. LAM is likely underreported, perhaps due to suboptimal case identification or referral. The health care utilization and mortality for LAM are high, suggesting that timely diagnosis and therapy could be beneficial. Disorders of mental health may be an unrecognized clinical feature of LAM. These results provide a population-based background for policymakers and researchers to better address the needs of patients with TSC and LAM. PMID: 25789699 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Kristof AS, Li PZ, Major P, Landry JS Tags: Chest Source Type: research

The Use of Indwelling Tunneled Pleural Catheters for Recurrent Pleural Effusions in Patients with Hematologic Malignancies: A Multicenter Study.
CONCLUSION: We present the largest study examining clinical outcomes related to indwelling tunneled pleural catheter placement in patients with hematologic malignancy. An overall 7.7% infection risk and 2.2% mortality was identified, similar to previously reported studies, despite the significant immunosuppression and pancytopenia often present within this population. Indwelling tunneled pleural catheter placement appears to remain a reasonable clinical option for patients with recurrent pleural effusions related to hematologic malignancy. PMID: 25789576 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Gilbert CR, Lee HJ, Skalski JH, Maldonado F, Wahidi M, Choi PJ, Bessich J, Sterman D, Argento AC, Shojaee S, Gorden JA, Wilshire CL, Feller-Kopman D, Ortiz R, Nonyane BA, Yarmus L Tags: Chest Source Type: research

The feasibility, accuracy and impact of Xpert MTB/RIF testing in a remote Aboriginal community in Canada.
Conclusions: In a predominantly Inuit population in a remote region of Canada where the burden of TB is high and no TB testing facilities are available, on-site Xpert was feasible, accurate and shortened time to TB treatment initiation. PMID: 25789458 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - March 19, 2015 Category: Respiratory Medicine Authors: Alvarez GG, Van Dyk DD, Desjardins M, Yasseen AS, Aaron SD, Cameron DW, Obed N, Baikie M, Pakhale S, Denkinger CM, Sohn H, Pai M Tags: Chest Source Type: research

Proton pencil beam scanning for mediastinal lymphoma: the impact of interplay between target motion and beam scanning.
Abstract The purpose of this study was to assess the feasibility of proton pencil beam scanning (PBS) for the treatment of mediastinal lymphoma. A group of 7 patients of varying tumor size (100-800 cc) were planned using a PBS anterior field. We investigated 17 fractions of 1.8 Gy(RBE) to deliver 30.6 Gy(RBE) to the internal target volume (ITV). Spots with σ ranging from 4 mm to 8 mm were used for all patients, while larger spots (σ = 6-16 mm) were employed for patients with motion perpendicular to the beam (⩾5 mm), based on initial 4-dimensional computed tomography (4D CT) motion evaluation. We consid...
Source: Physics in Medicine and Biology - March 19, 2015 Category: Physics Authors: Zeng C, Plastaras JP, Tochner ZA, White BM, Hill-Kayser CE, Hahn SM, Both S Tags: Phys Med Biol Source Type: research

Marivita lacus sp. nov., isolated from a saline lake.
Abstract A Gram-staining-negative, strictly heterotrophic and aerobic bacterium, strain TS-T44T, was isolated from a saline lake, Tuosu Lake in Qaidam basin, Qinghai province, China. Its taxonomic position was investigated using a polyphasic approach. Cells of strain TS-T44T were non-endospore-forming, non-motile rods, 0.8-1.2 µm wide and 1.2-3.0 µm long. Catalase- and oxidase-positive. Growth occurred in the presence of NaCl up to 8 % (w/v, optimum, 3.0 %), and at 15-35 °C (optimum, 25 °C) and pH 7.0-10.0 (optimum, pH 7.5-8.5). C18:1ω7c was the only predominant fatty acid. The major respiratory quinone was Q-...
Source: International Journal of Systematic and Evolutionary Microbiology - March 19, 2015 Category: Microbiology Authors: Zhong ZP, Liu Y, Hou TT, Liu HC, Zhou YG, Wang F, Liu ZP Tags: Int J Syst Evol Microbiol Source Type: research

Quantitative analysis of proteome and lipidome dynamics reveals functional regulation of global lipid metabolism.
Abstract Elucidating how and to what extent lipid metabolism is remodeled under changing conditions is essential for understanding cellular physiology. Here, we analyzed proteome and lipidome dynamics to investigate how regulation of lipid metabolism at the global scale supports remodeling of cellular architecture and processes during physiological adaptations in yeast. Our results reveal that activation of cardiolipin synthesis and remodeling supports mitochondrial biogenesis in the transition from fermentative to respiratory metabolism, that down-regulation of de novo sterol synthesis machinery prompts differenti...
Source: Chemistry and Biology - March 19, 2015 Category: Chemistry Authors: Casanovas A, Sprenger RR, Tarasov K, Ruckerbauer DE, Hannibal-Bach HK, Zanghellini J, Jensen ON, Ejsing CS Tags: Chem Biol Source Type: research

Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects.
CONCLUSION: This study suggests the presence of Type I hypersensitivity in addition to a Type IV immune reaction in patients with chronic systemic symptoms related to nickel. Nickel containing dental alloys and oral nickel intake seem to trigger systemic symptoms in previously nickel sensitized patients. PMID: 25797346 [PubMed - as supplied by publisher] (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 19, 2015 Category: Allergy & Immunology Authors: Büyüköztürk S, Gelincik A, Ünal D, Demirtürk M, Çelik DD, Erden S, Çolakoğlu B, Erdem Kuruca S Tags: Int Immunopharmacol Source Type: research

Are the Diagnostic Criteria for Asthma-COPD Overlap Syndrome Appropriate in Biomass Smoke-Induced chronic obstructive pulmonary disease?
PMID: 25799499 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - March 19, 2015 Category: Respiratory Medicine Authors: Golpe R, Pérez de Llano L Tags: Arch Bronconeumol Source Type: research

Using epidemics to map H3 equine influenza virus determinants of antigenicity.
Abstract Equine influenza is a major cause of respiratory infections in horses and causes widespread epidemics, despite the availability of commercial vaccines. Antigenic drift within the haemagglutinin (HA) glycoprotein is thought to play a part in vaccination breakdown. Here, we carried out a detailed investigation of the 1989 UK outbreak, using reverse genetics and site-directed mutagenesis, to determine the individual contribution of amino acid substitutions within HA. Mutations at positions 159, 189 and 227 all altered antigenicity, as measured by haemagglutination-inhibition assays. We also compared HA sequen...
Source: Virology - March 19, 2015 Category: Virology Authors: Woodward A, Rash AS, Medcalf E, Bryant NA, Elton DM Tags: Virology Source Type: research

Position document: IgE-mediated cow's milk allergy.
y) Abstract The present document offers an update on the recommendations for managing patients with cow's milk allergy - a disorder that manifests in the first year of life, with an estimated prevalence of 1.6-3% in this paediatric age group. The main causal allergens are the caseins and proteins in lactoserum (beta-lactoglobulin, alpha-lactoalbumin), and the clinical manifestations are highly variable in terms of their presentation and severity. Most allergic reactions affect the skin, followed by the gastrointestinal and respiratory systems, and severe anaphylaxis may occur. The diagnosis of cow's milk allergy is...
Source: Allergologia et Immunopathologia - March 19, 2015 Category: Allergy & Immunology Authors: Martorell-Aragonés A, Echeverría-Zudaire L, Alonso-Lebrero E, Boné-Calvo J, Martín-Muñoz MF, Nevot-Falcó S, Piquer-Gibert M, Valdesoiro-Navarrete L, Food allergy committee of SEICAP (Spanish Society of Pediatric Allergy, Asthma and Clinical Immunolo Tags: Allergol Immunopathol (Madr) Source Type: research

Diagnosis of Sarcoidosis
Abstract The diagnosis of sarcoidosis, a systemic granulomatous disease, is based on a compatible clinical–radiological picture and the histological evidence of noncaseating granulomas. Other diseases mimicking sarcoidosis, mostly infections and other granulomatoses, have to be excluded. There is no single test for sarcoidosis, and the presence of granulomas alone does not establish the diagnosis. Symptoms of sarcoidosis are not specific and can be markedly different according to organ involvement and disease course. Respiratory symptoms and fatigue are the most common symptoms at any stage of disease. Histologi...
Source: Clinical Reviews in Allergy and Immunology - March 18, 2015 Category: Allergy & Immunology Source Type: research

Acute respiratory distress syndrome: we can’t miss regional lung perfusion!
In adult respiratory distress syndrome (ARDS), life-threatening hypoxemia may occur, dictating the need for differentiated ventilator strategies. Pronounced consolidation and/or atelectasis have been well documented in ARDS, but the contribution of regional perfusion to oxygenation has been poorly addressed. Evidence has accumulated that, in ARDS, regional perfusion is extremely variable and may affect oxygenation, independently from the amount of atelectatic-consolidated lung regions. Thus, the response in oxygenation to different ventilatory settings, both during controlled and assisted mechanical ventilation, should be ...
Source: BMC Anesthesiology - March 18, 2015 Category: Anesthesiology Authors: Paolo PelosiMarcelo de Abreu Source Type: research

Massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum after multiple direct laryngoscopies: an autopsy case report
We present the detailed pathological findings in a patient with severe ETI-related complications. A 77-year-old obese male suffered cardiopulmonary arrest after choking at a rehabilitation facility. Spontaneous circulation returned after chest compressions and foreign-body removal. After multiple failed direct laryngoscopies, the patient was transferred to our hospital. He had massive subcutaneous emphysema, bilateral pneumothorax, pneumomediastinum, pneumoperitoneum, pneumoretroperitoneum, and pneumoscrotum on admission, and died from hypoxic brain injury 15 h later. Autopsy revealed severe oropharyngeal, laryngeal, and ...
Source: Journal of Anesthesia - March 18, 2015 Category: Anesthesiology Source Type: research

Echinacea Reduces the Risk of Recurrent Respiratory Tract Infections and Complications: A Meta-Analysis of Randomized Controlled Trials
Conclusion Evidence indicates that echinacea potently lowers the risk of recurrent respiratory infections and complications thereof. Immune modulatory, antiviral, and anti-inflammatory effects might contribute to the observed clinical benefits, which appear strongest in susceptible individuals. (Source: Advances in Therapy)
Source: Advances in Therapy - March 18, 2015 Category: Drugs & Pharmacology Source Type: research

Respiratory Distress Secondary to Rhabdomyosarcoma of the Tongue and Co-existent Choanal Atresia
Abstract Whilst rhabdomyosarcoma (RMS) is the third most common solid tumour in children, congenital RMS of the tongue is extremely rare and usually present as painless progressive mass since birth (Dagher and Helman in Oncologist 4:34–44, 1999; Childs and Goudy in Int J Pediatr Otorhinolaryngol 5:126–128, 2010). In neonates, presentation with respiratory distress is unexpected as neonates are preferential nasal breathers and restricted oral breathing due to tumour usually poses no problem. We herein report a case of rhabdomyosarcoma of the tongue with co-existent unilateral choanal atresia, presenting with re...
Source: Journal of Maxillofacial and Oral Surgery - March 18, 2015 Category: ENT & OMF Source Type: research

Early Mandibular Distraction to Relieve Robin Severe Airway Obstruction in Two Siblings with Lymphedema–Distichiasis Syndrome
Abstract Although micrognathia and cleft palate have been reported in patients with Lymphedema–distichiasis syndrome (LDS), the classic Robin sequence with glossoptosis and airway obstruction has not been previously described in patients with genetically confirmed LDS. Here we report on two female siblings with LDS confirmed by a FOXC2 mutation who presented at birth with severe airway obstruction related to Robin sequence. Respiratory obstruction was successfully managed by early distraction osteogenesis. Our report highlights the unusual occurrence of Robin sequence in LDS patients and advises distraction ...
Source: Journal of Maxillofacial and Oral Surgery - March 18, 2015 Category: ENT & OMF Source Type: research

High mobility group box 1 contributes to anti-neutrophil cytoplasmic antibody-induced neutrophils activation through receptor for advanced glycation end products (RAGE) and Toll-like receptor 4
Conclusions: HMGB1 could prime neutrophils by increasing ANCA antigens translocation, and the primed neutrophils could be further induced by ANCA, resulting in the respiratory burst and degranulation. This process is TLR4- and RAGE-dependent through MyD88/NF-κB pathway. (Source: BioMed Central)
Source: BioMed Central - March 18, 2015 Category: Journals (General) Authors: Chen WangHuan WangDong-Yuan ChangJian HaoMing-Hui ZhaoMin Chen Source Type: research

Acute respiratory distress syndrome: we can’t miss regional lung perfusion!
In adult respiratory distress syndrome (ARDS), life-threatening hypoxemia may occur, dictating the need for differentiated ventilator strategies. Pronounced consolidation and/or atelectasis have been well documented in ARDS, but the contribution of regional perfusion to oxygenation has been poorly addressed. Evidence has accumulated that, in ARDS, regional perfusion is extremely variable and may affect oxygenation, independently from the amount of atelectatic-consolidated lung regions. Thus, the response in oxygenation to different ventilatory settings, both during controlled and assisted mechanical ventilation, should be ...
Source: BioMed Central - March 18, 2015 Category: Journals (General) Authors: Paolo PelosiMarcelo de Abreu Source Type: research

A large-scale survey of adverse events experienced in yoga classes
Conclusions: The results of this large-scale survey demonstrated that approximately 30% of yoga class attendees had experienced some type of adverse event. Although the majority had mild symptoms, the survey results indicated that attendees with chronic diseases were more likely to experience adverse events associated with their disease. Therefore, special attention is necessary when yoga is introduced to patients with stress-related, chronic diseases. (Source: BioPsychoSocial Medicine)
Source: BioPsychoSocial Medicine - March 18, 2015 Category: Psychiatry & Psychology Authors: Tomoko MatsushitaTakakazu Oka Source Type: research

Relative contributions of emphysema and airway remodelling to airflow limitation in COPD: Consistent results from two cohorts
Conclusions%LAV predicts both FEV1/FVC and FEV1 better than Pi10 in patients with COPD. Thus, emphysema may make a greater contribution to airflow limitation than airway remodelling in COPD. (Source: Respirology)
Source: Respirology - March 18, 2015 Category: Respiratory Medicine Authors: Nguyen Van Tho, Yasushi Ryujin, Emiko Ogawa, Le Thi Huyen Trang, Rie Kanda, Kenichi Goto, Masafumi Yamaguchi, Taishi Nagao, Le Thi Tuyet Lan, Yasutaka Nakano Tags: Original Article Source Type: research

Prevalence of chronic obstructive pulmonary disease and variation in risk factors across four geographically diverse resource-limited settings in Peru
Background: It is unclear how geographic and social diversity affects the prevalence of chronic obstructive pulmonary disease (COPD). We sought to characterize the prevalence of COPD and identify risk factors across four settings in Peru with varying degrees of urbanization, altitude, and biomass fuel use. Methods: We collected sociodemographics, clinical history, and post-bronchodilator spirometry in a randomly selected, age-, sex- and site-stratified, population-based sample of 2,957 adults aged ≥35 years (median age was 54.8 years and 49.3% were men) from four resource-poor settings: Lima, Tumbes, urban and rural Pu...
Source: Respiratory Research - March 18, 2015 Category: Respiratory Medicine Authors: Devan JaganathJ MirandaRobert GilmanRobert WiseGregory DietteCatherine MieleAntonio Bernabe-OrtizWilliam CheckleyCRONICAS Cohort Study Group Source Type: research

IL-25 induces airways angiogenesis and expression of multiple angiogenic factors in a murine asthma model
Conclusions: The data suggest that chronic exposure of murine airways to IL-25 alone is able to reproduce a local angiogenic milieu. Thus, blocking IL-25 may attenuate vascular remodelling and improve outcomes in asthma patients. (Source: Respiratory Research)
Source: Respiratory Research - March 18, 2015 Category: Respiratory Medicine Authors: Xiujuan YaoWei WangYan LiPing HuangQian ZhangJingjing WangWen WangZhe LvYunqing AnJianguo QinChris CorriganKewu HuangYongchang SunSun Ying Source Type: research

Chinese herbal medicine as adjuvant treatment to chemotherapy for multidrug-resistant tuberculosis (MDR-TB): a systematic review of randomised clinical trials
Chinese herbal medicine (CHM) has been increasingly used as an adjuvant treatment for multi-drug resistant tuberculosis (MDR-TB) in China. To inform clinical practice, we performed a systematic review on the beneficial effect and safety of CHM for MDR-TB. (Source: Tuberculosis)
Source: Tuberculosis - March 18, 2015 Category: Respiratory Medicine Authors: Mei Wang, Xin Guan, Yuan Chi, Nicola Robinson, Jian-Ping Liu Tags: Review Source Type: research

Cardiopulmonary changes with aeration of the newborn lung
The newborns transition from fetal to neonatal life includes aeration of the lungs, establishment of pulmonary gas exchange and a changing the fetal circulation into the adult phenotype. This review summarizes the latest research findings, which show that lung aeration, airway liquid clearance and cardiovascular changes are directly interconnected at birth. The mechanisms of airway liquid clearance at birth are reviewed and the particular importance of the transpulmonary pressure gradient during lung aeration is discussed. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 18, 2015 Category: Respiratory Medicine Authors: Stuart Brian Hooper, Graeme Roger Polglase, Charles Christoph Roehr Source Type: research

Paediatric Tracheomalacia
Intrathoracic tracheomalacia is characterized by increased compliance of the central airway within the thorax. This leads to excessive dynamic collapse during exhalation or periods of increased intrathoracic pressure such as crying. Extrathoracic tracheomalacia involves dynamic collapse of the airway between the glottis and sternal notch that occurs during inhalation rather than exhalation. The tone of the posterior membrane of the trachea increases throughout development and childhood, as does the rigidity of the tracheal cartilage. (Source: Paediatric Respiratory Reviews)
Source: Paediatric Respiratory Reviews - March 18, 2015 Category: Respiratory Medicine Authors: Erik B. Hysinger, Howard B. Panitch Source Type: research

Electronic cigarette use and harm reversal: emerging evidence in the lung
Riccardo Polosa discusses the emerging evidence on electronic cigarette (EC) use and respiratory outcomes, highlighting the early data suggesting benefits when smokers switch from tobacco smoking to EC use, which should be considered in policy making. (Source: BMC Medicine)
Source: BMC Medicine - March 18, 2015 Category: Internal Medicine Authors: Riccardo Polosa Source Type: research

Isolation and full genome characterization of avian influenza subtype H9N2 from poultry respiratory disease outbreak in Egypt
In conclusion, avian influenza H9N2 virus is circulating in Egyptian chicken farms causing respiratory manifestations. Continuous monitoring of the molecular epidemiology and its impact on the virulence as well as emergence of new strains are necessary. (Source: Virus Genes)
Source: Virus Genes - March 18, 2015 Category: Genetics & Stem Cells Source Type: research

Metabolic control of respiratory levels in coenzyme Q biosynthesis‐deficient Escherichia coli strains leading to fine‐tune aerobic lactate fermentation
This article is protected by copyright. All rights reserved (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - March 18, 2015 Category: Biomedical Science Authors: Hui Wu, George N. Bennett, Ka‐Yiu San Tags: Engineering Science of Biological Systems Source Type: research

Pregnancy limits lung function during exercise and depresses metabolic rate in the skink Tiliqua nigrolutea [RESEARCH ARTICLE]
In this study, breathing patterns, metabolic rates, lung volume and lung diffusing capacity were measured at rest and during exercise in the pregnant skink Tiliqua nigrolutea. Breathing patterns were largely unaffected by gestation; however, decreases in metabolic rate (rate of oxygen consumption) in the late stages of pregnancy induced a relative hyperventilation. The reductions in metabolic rate during late pregnancy prevent the calculation of the maintenance cost of pregnancy based on post-partum and neonatal metabolic rates. Despite the high relative litter mass of 38.9±5.3%, lung diffusing capacity was maintain...
Source: Journal of Experimental Biology - March 18, 2015 Category: Biology Authors: Munns, S. L., Edwards, A., Nicol, S., Frappell, P. B. Tags: RESEARCH ARTICLE Source Type: research

Clinical Relevance of Multiple Respiratory Virus Detection in Adult Patients with Acute Respiratory Illness [Virology]
Because increasing numbers of nasopharyngeal swab specimens from adult patients with acute respiratory illness (ARI) are being tested by respiratory virus (RV) multiplex reverse transcriptase PCR (RVM-RT-PCR), multiple RV detection (MRVD) is being encountered more frequently. However, the clinical relevance of MRVD in adult patients has rarely been evaluated. The clinical characteristics of hospitalized adult patients with ARI and MRVD by RVM-RT-PCR tests were compared to those of patients with single RV detection (SRVD) during a single year at a tertiary care center. MRVD was observed in 26 of the 190 adult patients (13.7...
Source: Journal of Clinical Microbiology - March 18, 2015 Category: Microbiology Authors: Choi, S.-H., Chung, J.-W., Kim, H. R. Tags: Virology Source Type: research

Development and Validation of a Rapid Immunochromatographic Assay for Detection of Middle East Respiratory Syndrome Coronavirus Antigen in Dromedary Camels [Clinical Veterinary Microbiology]
We present here a rapid immunochromatographic assay for the detection of Middle East respiratory syndrome coronavirus (MERS-CoV) antigen in the nasal swabs of dromedary camels. The assay is based on the detection of MERS-CoV nucleocapsid protein in a short time frame using highly selective monoclonal antibodies at room temperature. The relative sensitivity and specificity of the assay were found to be 93.90% and 100%, respectively, compared to that of the UpE and open reading frame 1A (Orf1A) real-time reverse transcriptase PCR (RT-PCR). The results suggest that the assay developed here is a useful tool for the rapid diagn...
Source: Journal of Clinical Microbiology - March 18, 2015 Category: Microbiology Authors: Song, D., Ha, G., Serhan, W., Eltahir, Y., Yusof, M., Hashem, F., Elsayed, E., Marzoug, B., Abdelazim, A., Al Muhairi, S. Tags: Clinical Veterinary Microbiology Source Type: research

Detection of a Transient R292K Mutation in Influenza A/H3N2 Viruses Shed for Several Weeks by an Immunocompromised Patient [Case Reports]
We describe the case of an immunocompromised patient, positive for influenza A virus (H3N2), in whom the neuraminidase R292K mutation was transiently detected during oseltamivir treatment. The R292K mutation was identified by direct testing in 3 of 11 respiratory specimens collected throughout the patient's illness but in none of the cultures from those specimens. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - March 18, 2015 Category: Microbiology Authors: Babady, N. E., Laplante, J. M., Tang, Y.-W., St. George, K. Tags: Case Reports Source Type: research

Frozen Master Mix-Based Modification of Commercial Reverse Transcriptase PCR for Detection of Influenza and Respiratory Syncytial Viruses [Letters To The Editor]
(Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - March 18, 2015 Category: Microbiology Authors: Wenninger, B., Munson, E., Napierala, M., Munson, K. L., Bilbo, D., Hryciuk, J. E. Tags: Letters To The Editor Source Type: research

Pathogenesis of natural and experimental Pseudorabies virus infections in dogs
Conclusions: Based on these results, we conclude that virally induced systemic hemorrhage, peripheral nervous system pathology, and/or cardiac injury can individually or collectively cause death in PRV-infected dogs. The respiratory signs of the disease are attributed to cardiogenic lesions. (Source: Virology Journal)
Source: Virology Journal - March 18, 2015 Category: Virology Authors: Letian ZhangCheng ZhongJushi WangZijie LuLei LiuWanlian YangYanli Lyu Source Type: research

Prospective evaluation of rhinovirus infection in healthy young children
Modern molecular methods of viral screening have shown that human rhinoviruses (HRVs) are members of the family Picornaviridae, genus Enterovirus, and can be divided into three species (HRV-A, HRV-B, and HRV-C) including many different viral types on the basis of their genetic characteristics [1]. They are all considered to be capable of causing respiratory disease as suggested by the frequent identification of the different HRV strains, alone or in association with other respiratory viruses [2], in the respiratory secretions of subjects with upper (URTI) or lower respiratory tract infection (LRTI) [3,4]. (Source: Journal ...
Source: Journal of Clinical Virology - March 18, 2015 Category: Virology Authors: Nicola Principi, Alberto Zampiero, Monia Gambino, Alessia Scala, Laura Senatore, Mara Lelii, Beatrice Ascolese, Claudio Pelucchi, Susanna Esposito Source Type: research

A gas chromatography–mass spectrometry based study on serum metabolomics in rats chronically poisoned with hydrogen sulfide
In this study, we developed a serum metabonomic method using orthogonal partial least squares-discriminate analysis (OPLS-DA), based on gas chromatography–mass spectrometry (GC/MS) to evaluate the effect of chronic poisoning by hydrogen sulfide in rats. The OPLS-DA data demonstrated that the model group (n = 60) differed significantly from the control group (n = 30), suggesting that the metabolic profiles of the two groups are markedly different. Alterations in the levels of some metabolites such as citrate, galactose, lactate, mannose, inositol, urea, phosphate, alanine and valine were detected by OPLS-DA analysis. ...
Source: Journal of Forensic and Legal Medicine - March 18, 2015 Category: Forensic Medicine Source Type: research

Intra-breath arterial oxygen oscillations detected by a fast oxygen sensor in an animal model of acute respiratory distress syndrome
Conclusions We conclude that these fibreoptic $$P{\hbox{ a }}_{{\mathrm{O}}_{2}}$$ sensors have the potential to become a diagnostic tool for CA in ARDS. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - March 18, 2015 Category: Anesthesiology Authors: Formenti, F., Chen, R., McPeak, H., Murison, P. J., Matejovic, M., Hahn, C. E. W., Farmery, A. D. Tags: Translational Research Source Type: research

Decreased expression of 14‐3‐3 σ, an early event of malignant transformation of respiratory epithelium, also facilitates progression of squamous cell lung cancer
ConclusionThe inactivation of 14‐3‐3 σ may be a very early event in tumorigenesis and could facilitate the initiation and progression of lung SqCC in a sustainable way. (Source: Thoracic Cancer)
Source: Thoracic Cancer - March 18, 2015 Category: Cancer & Oncology Authors: Nan Sun, Yongkai Wu, Bo Huang, Qian Liu, Yinan Dong, Jianqiao Ding, Yongyu Liu Tags: Original Article Source Type: research

Extensive respiratory chain defects in inhibitory interneurons in patients with mitochondrial disease
ConclusionsWe propose that the combined loss of interneurons and severe respiratory deficiency in remaining interneurons contribute to impaired neuronal network oscillations and could underlie development of neurological deficits, such as cognitive impairment and epilepsy, in mitochondrial disease. (Source: Neuropathology and Applied Neurobiology)
Source: Neuropathology and Applied Neurobiology - March 18, 2015 Category: Neurology Authors: Nichola Z. Lax, John Grady, Alex Laude, Felix Chan, Philippa D. Hepplewhite, Grainne Gorman, Roger G. Whittaker, Yi Ng, Mark O. Cunningham, Doug M. Turnbull Tags: Original Article Source Type: research