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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Development of a Homogeneous High-Throughput Screening Assay for Biological Inhibitors of Human Rhinovirus Infection
We describe the implementation of the method in an antibody screening campaign and demonstrate the biological relevance of the assay by confirming the activity of resultant antibodies in a cell-based in vitro HRV infection assay.
Source: Journal of Biomolecular Screening - February 8, 2013 Category: Molecular Biology Authors: Newton, P., O'Shea, D., Wells, E., Moakes, K., Dunmore, R., Butler, R. J., Wilkinson, T., Ward, A., Casson, N., Strain, M., Vousden, K., Lowe, D. C., Pattison, D. V., Carruthers, A. M., Sleeman, M. A., Vaughan, T. J., Harrison, P. Tags: Original Research Source Type: research

Mitochondrial CYP2D6 Oxidation of MPTP to Toxic MPP+ [Bioenergetics]
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxic side product formed in the chemical synthesis of desmethylprodine opioid analgesic, which induces Parkinson disease. Monoamine oxidase B, present in the mitochondrial outer membrane of glial cells, catalyzes the oxidation of MPTP to the toxic 1-methyl-4-phenylpyridinium ion (MPP+), which then targets the dopaminergic neurons causing neuronal death. Here, we demonstrate that mitochondrion-targeted human cytochrome P450 2D6 (CYP2D6), supported by mitochondrial adrenodoxin and adrenodoxin reductase, can efficiently catalyze the metabolism of MPTP to MPP+, as ...
Source: Journal of Biological Chemistry - February 8, 2013 Category: Chemistry Authors: Bajpai, P., Sangar, M. C., Singh, S., Tang, W., Bansal, S., Chowdhury, G., Cheng, Q., Fang, J.-K., Martin, M. V., Guengerich, F. P., Avadhani, N. G. Tags: Metabolism Source Type: research

{gamma}-Hydroxybutyrate and Glycine Regulate Glucagon Secretion [Molecular Bases of Disease]
Paracrine signaling between pancreatic islet β-cells and α-cells has been proposed to play a role in regulating glucagon responses to elevated glucose and hypoglycemia. To examine this possibility in human islets, we used a metabolomic approach to trace the responses of amino acids and other potential neurotransmitters to stimulation with [U-13C]glucose in both normal individuals and type 2 diabetics. Islets from type 2 diabetics uniformly showed decreased glucose stimulation of insulin secretion and respiratory rate but demonstrated two different patterns of glucagon responses to glucose: one group responded normally to...
Source: Journal of Biological Chemistry - February 8, 2013 Category: Chemistry Authors: Li, C., Liu, C., Nissim, I., Chen, J., Chen, P., Doliba, N., Zhang, T., , Daikhin, Y., Stokes, D., Yudkoff, M., Bennett, M. J., Stanley, C. A., Matschinsky, F. M., Naji, A. Tags: Metabolism Source Type: research

Plasma kallistatin levels in patients with severe community-acquired pneumonia
Conclusions: These results suggest that kallistatin may serve as a novel marker for severe CAP prognosis, and may be involved in the pathogenesis of CAP through anti-inflammatory and anti-coagulation effects.
Source: Critical Care - February 8, 2013 Category: Intensive Care Authors: Wei-Chieh LinShiou-Ling LuChiou-Feng LinChang-Wen ChenLee ChaoJulie ChaoYee-Shin Lin Source Type: research

Dysfunctional Mitochondria Modulate cAMP-PKA Signaling and Filamentous and Invasive Growth of Saccharomyces cerevisiae [Cellular Genetics]
In this study, we analyzed defective filamentous and invasive growth of the yeast Saccharomyces cerevisiae strains that have a dysfunctional mitochondrial genome (rho mutants). We found that the morphogenetic defect of rho mutants was caused by specific downregulation of FLO11, the adhesin essential for invasive and filamentous growth, and did not result from general metabolic changes brought about by interorganellar retrograde signaling. Transcription of FLO11 is known to be regulated by several signaling pathways, including the filamentous-growth-specific MAPK and cAMP-activated protein kinase A (cAMP-PKA) pathways. Our ...
Source: Genetics - February 8, 2013 Category: Genetics & Stem Cells Authors: Aun, A., Tamm, T., Sedman, J. Tags: Cellular Genetics Source Type: research

Comparative Emissions of Random Orbital Sanding between Conventional and Self-Generated Vacuum Systems
Conventional abrasive sanding generates high concentrations of particles. Depending on the substrate being abraded and exposure duration, overexposure to the particles can cause negative health effects ranging from respiratory irritation to cancer. The goal of this study was to understand the differences in particle emissions between a conventional random orbital sanding system and a self-generated vacuum random orbital sanding system with attached particle filtration bag. Particle concentrations were sampled for each system in a controlled test chamber for oak wood, chromate painted (hexavalent chromium) steel panels, and...
Source: Annals of Occupational Hygiene - February 8, 2013 Category: Occupational Health Authors: Liverseed, D. R., Logan, P. W., Johnson, C. E., Morey, S. Z., Raynor, P. C. Tags: Original Article Source Type: research

Personal Exposure to Dust and Endotoxin in Robusta and Arabica Coffee Processing Factories in Tanzania
Conclusions: Dust and endotoxin exposure is high, in particular when processing dry pre-processed coffee. Minimization of dust emissions and use of efficient dust exhaust systems are important to prevent the development of respiratory system impairment in workers.
Source: Annals of Occupational Hygiene - February 8, 2013 Category: Occupational Health Authors: Sakwari, G., Mamuya, S. H. D., Bratveit, M., Larsson, L., Pehrson, C., Moen, B. E. Tags: Original Article Source Type: research

Measurement of Endotoxins in Bioaerosols at Workplace: A Critical Review of Literature and a Standardization Issue
This article is both a reference document for all operators wishing to use such methods and a working document to build international consensus around the measurement of airborne endotoxins.
Source: Annals of Occupational Hygiene - February 8, 2013 Category: Occupational Health Authors: Duquenne, P., Marchand, G., Duchaine, C. Tags: Review Source Type: research

Diverging trends of chronic bronchitis and smoking habits between 1998 and 2010
Conclusions: Despite the significant reduction in current smoking, CB prevalence did not vary among young Italian adults. The temporal pattern of CB prevalence can only be partly explained by the increase of unemployment/premature retirement, asthma and allergic rhinitis, and suggests that other factors could have played a role.
Source: Respiratory Research - February 8, 2013 Category: Respiratory Medicine Authors: Simone AccordiniAngelo CorsicoIsa CerveriLeonardo AntonicelliFrancesco AttenaRoberto BonoLucio CasaliMarcello FerrariAlessandro FoisPierpaolo MarchettiPietro PirinaRoberta TassinariGiuseppe VerlatoRoberto de Marco Source Type: research

Work of breathing as a tool to diagnose severe fixed upper airway obstruction
In conclusion, the major message of this case report is that measurement of the work of breathing was able to document the “fixed” nature of the airway obstruction, by showing no improvement even with highest tolerated levels of nasal CPAP. As such, the work of breathing may be proposed as a screening tool to quantify and assess the reversibility of severe upper airway obstruction in children. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: S. Khirani, S. Pierrot, N. Leboulanger, A. Ramirez, D. Breton, V. Couloigner, B. Fauroux Tags: Case Report Source Type: research

An interesting case of Dysautonomia presenting with Dyspnea
Abstract Dysautonomia such as POTS syndrome presenting with respiratory symptoms can often be misdiagnosed for other common pulmonary conditions. It can be diagnosed with a comprehensive history and orthostatic vital measurement. Simple diagnostic test such as diffusing capacity in supine and standing position can emerge as a noninvasive tool to guide the long‐term monitoring and treatment response. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Rizwana Popatia, Meera Subramaniam Tags: Case Report Source Type: research

Validation of novel wheeze phenotypes using longitudinal airway function and atopic sensitization data in the first 6 years of life: Evidence from the Southampton Women's survey
ConclusionSWS cohort data validates the statistically derived ALSPAC six‐class model. In particular, lung function and atopy successfully differentiate persistent, late‐onset and intermediate‐onset wheeze, whilst the Tucson “transient early” wheeze phenotype can be sub‐classified into groups that reflect early lung function. Since the 4‐class model fails to adequately differentiate phenotypes based on lung function and atopy, we propose that strong consideration be given to using the 6‐class paradigm for longitudinal outcome work in wheezing with onset in early life. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Samuel A. Collins, Katharine C. Pike, Hazel M. Inskip, Keith M. Godfrey, Graham Roberts, John W. Holloway, Jane S.A. Lucas, Tags: Original Article: Epidemiology Source Type: research

Cystic fibrosis in a Hispanic adolescent
We describe the presentation of a Hispanic adolescent with chronic respiratory symptoms and poor growth that led to a diagnosis of cystic fibrosis (CF) based on an indeterminate sweat chloride result and DNA sequence analysis that revealed a single new frameshift mutation, Nt3878insATCAG, which results in a premature stop codon in exon 20 of the CFTR gene. This case, highlighted by the identification of a deleterious, disease‐causing mutation, illustrates the importance of maintaining both a high clinical suspicion for CF and low threshold for obtaining genetic testing in a non‐Caucasian Hispanic adolescent with a char...
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Jenny H. Lin, Joseph M. Collaco, Shruti M. Paranjape Tags: Case Report Source Type: research

Pneumonectomy: Could it have been another history?
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Luis Moral Tags: Letter to the Editor Source Type: research

Effects of prednisolone on refractory Mycoplasma pneumoniae pneumonia in children
ConclusionsAzithromycin combined with prednisolone is a better treatment for children with refractory MPP than azithromycin alone. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Zhengxiu Luo, Jian Luo, Enmei Liu, Xiujuan Xu, Yulin Liu, Fengqiong Zeng, Subi Li, Zhou Fu Tags: Original Article: Respiratory Infections Source Type: research

An infant with pulmonary interstitial glycogenosis: Clinical improvement is associated with improvement in the pulmonary diffusion capacity
Abstract Pulmonary interstitial glycogenosis (PIG) is an idiopathic interstitial lung disease of infants. The underlying pulmonary pathophysiology of PIG has not been well characterized. Herein we report a term‐gestatation infant who presented with persistent tachypnea and hypoxia. A chest CT scan demonstrated a diffuse ground glass appearance and lung biopsy demonstrated increased alveolar septae cellularity with glycogen‐containing cells, consistent with a diagnosis of PIG. At 3 months of age, pulmonary function testing included: pre‐ and post‐bronchodilator forced expiratory flows using the raised‐volume techn...
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Zarmina Ehsan, Gregory S. Montgomery, Christina Tiller, Jeffrey Kisling, Daniel V. Chang, Robert S. Tepper Tags: Case Report Source Type: research

Fungal sensitization in childhood persistent asthma is associated with disease severity
ConclusionsFungal sensitization in children with persistent asthma is associated with disease severity. Almost 60% of our severe persistent asthma patients had evidence of fungal sensitization and, based on our previous studies, may be potential candidates for anti‐fungal therapy. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Alfin G. Vicencio, Maria Teresa Santiago, Kalliope Tsirilakis, Anne Stone, Stefan Worgall, Elizabeth A. Foley, Douglas Bush, David L. Goldman Tags: Original Article: Asthma Source Type: research

Differential effects of immaturity and neonatal lung disease on the lung function of very low birth weight infants at 48–52 postconceptional weeks
ConclusionsLung function after discharge of VLBW infants is differentially affected by both immaturity and NLD requiring MV. With increasing prematurity, intubated and mechanically ventilated infants are at increased risk of developing impaired lung function which can be detected by LFT. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Gerd Schmalisch, Silke Wilitzki, Charles C. Roehr, Hans Proquitté, Christoph Bührer Tags: Original Article: Neonatal Lung Disease Source Type: research

Characterization of pulmonary function impairments in patients with mucopolysaccharidoses—changes with age and treatment
ConclusionOur additional characterization of the types and prevalence of pulmonary function abnormalities seen in MPS patients should be useful for clinical care. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Shuan‐Pei Lin, Shou‐Chuan Shih, Chih‐Kuang Chuang, Kuo‐Sheng Lee, Ming‐Ren Chen, Dau‐Ming Niu, Pao Chin Chiu, Shio Jean Lin, Hsiang‐Yu Lin Tags: Original Article: Other Source Type: research

Increased lung volume in infants and toddlers at high compared to low altitude
Abstract Children and adults residing at high altitude (HA) compared to low altitude (LA) have larger lung volumes; however, it is unknown whether this response to chronic hypoxia begins early in life. Our objective was to determine whether infants and toddlers at HA have larger lung volumes compared to infants and toddlers at LA. Oxygen saturation (SaO2), functional residual capacity (FRC), as well as serum levels of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were measured in infants and toddlers from HA (N = 50; 3,440 m) and LA (N = 35; 440 m). There were no significant differences in ...
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Conrado J. Llapur, Myriam R. Martínez, María Marta Caram, Federico Bonilla, Celia Cabana, Zhansheng Yu, Robert S. Tepper Tags: Original Article: Pulmonary Physiology Source Type: research

Indigenous children from three countries with non‐cystic fibrosis chronic suppurative lung disease/bronchiectasis
DiscussionIndigenous children with CSLD/bronchiectasis from three developed countries experience significant disparities in poverty indices in common with their respective indigenous population; however, household crowding, prematurity and early ALRIs were more common in study children than their local indigenous population. Addressing equity, especially by preventing prematurity and ALRIs, should reduce risk of CSLD/bronchiectasis in indigenous children. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Rosalyn J. Singleton, Patricia C. Valery, Peter Morris, Catherine A. Byrnes, Keith Grimwood, Gregory Redding, Paul J. Torzillo, Gabrielle McCallum, Lori Chikoyak, Charmaine Mobberly, Robert C. Holman, Anne B. Chang Tags: Original Article: Other Source Type: research

Macrophage activation syndrome induced by A/H1N1 influenza in cystic fibrosis
Abstract Bacterial respiratory infections have an important impact on the development and progression of pulmonary disease in cystic fibrosis (CF). Viral infections are possible triggers of acute deterioration in the clinical status of CF patients. Macrophage activation syndrome (MAS) is a life‐threatening complication of rheumatic disease characterized by pancytopenia, hepatitis, hyperferritinemia, coagulopathy, and neurologic symptoms. This syndrome is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well‐differentiated macrophages, leading to widespread hemophagocytosis and ...
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Rosaria Casciaro, Federico Cresta, Federica Favilli, Aldo Naselli, Alessandra De Alessandri, Laura Minicucci Tags: Case Report Source Type: research

Moxifloxacin for the treatment of pulmonary tuberculosis in children: A single center experience
ConclusionsA moxifloxacin‐containing regimen might be considered for the treatment of TB in children, especially for drug‐resistant and extensive forms. However, vigilance for possible side effects is recommended, especially if other drugs are concomitantly used. Studies on wider populations are needed to better define the impact of long‐term treatments with quinolones on children's growth and psychomotor development and to outline regulatory indications on moxifloxacin use in the pediatric setting. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Silvia Garazzino, Carlo Scolfaro, Irene Raffaldi, Anna Maria Barbui, Luigi Luccoli, Pier‐Angelo Tovo Tags: Original Article: Respiratory Infections Source Type: research

Spirometric reference values in urban children in Madagascar: Poverty is a risk factor for low lung function
ConclusionsThe equations established for school children in Madagascar's capital Antananarivo showed lung function values were lower than reference values for the same age group seen not only in European, but also in African American and African children. The unique ethnicity of the Malagasy people, which combines Southeast‐Asian with substantial African influences, the heavy burden of pollution and poverty may explain these differences. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Peter Th. Wolff, Lala Arison, Abel Rahajamiakatra, Francis Raserijaona, Bodo Niggemann Tags: Original Article: Pulmonary Physiology Source Type: research

Tidal breathing FeNO measurements: A new algorithm
ConclusionTidal breathing FeNO values could be transformed with a new algorithm to match single breath FeNO at a constant flow of 50 ml/sec. This algorithm opens the way to standardized FeNO measurements in preschool children and uncooperative patients. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Esther van Mastrigt, Ruben C.A. de Groot, Hans W. van Kesteren, Anton T.J. Vink, Johan C. de Jongste, Mariëlle W.H. Pijnenburg Tags: Original Article: Asthma Source Type: research

Induced sputum cell count and cytokine profile in atopic and non‐atopic children with asthma
ConclusionsAs compared to HC, the inflammatory profile in induced sputum of children with asthma showed an increase in proinflammatory cytokines. Concentrations of IL‐10, an anti‐inflammatory cytokine, were lower in children with AA than in HC. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: G. Vizmanos‐Lamotte, A. Moreno‐Galdó, X. Muñoz, S. Gómez‐Ollés, S. Gartner, M.J. Cruz Tags: Original Article: Asthma Source Type: research

Developmental changes in diaphragm muscle function in the preterm and postnatal lamb
ConclusionThese data indicate that the functional capacity of the diaphragm varies with maturational age and may be an important determinant of the susceptibility to preterm respiratory failure. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: T. Lavin, Y. Song, A.J. Bakker, C.J. McLean, W.A. Macdonald, P.B. Noble, C.A. Berry, J.J. Pillow, G.J. Pinniger Tags: Original Article: Cell & Animal Studies Source Type: research

Determinants of quality of life in children with asthma
ConclusionsIn conclusion, the evaluation of asthma HRQoL independently reflects the asthma control state and a dimension of its severity. These results highlight the need to modify asthma management strategy. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Konstantinos Th. Petsios, Kostas N. Priftis, Elpis Hatziagorou, John N. Tsanakas, George Antonogeorgos, Vasiliki N. Matziou Tags: Original Article: Asthma Source Type: research

The effect of grand maternal nicotine exposure during gestation and lactation on lung integrity of the F2 generation
ConclusionGrand‐maternal nicotine exposure induces structural changes in the lungs of the F2 generation that resembled premature aging. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Gert S. Maritz, Muyunda Mutemwa Tags: Original Article: Pulmonary Physiology Source Type: research

Predictors of severity and mortality in children hospitalized with respiratory syncytial virus infection in a tropical region
ConclusionsRSV is an important cause of ALRI in infants and young children living in tropical regions, especially during the rainy season. The identified predictors of severe disease and mortality should be taken into account when planning interventions to reduce the burden of ALRI in young children living in these regions. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Diego Andrés Rodríguez, Carlos E. Rodriguez‐Martinez, Andrea Constanza Cárdenas, Ivonne Emilce Quilaguy, Leydy Yasmin Mayorga, Luz Marlesvy Falla, Gustavo Nino Tags: Original Article: Respiratory Infections Source Type: research

Reference standards for forced expiratory indices in Chinese preschool children
This study justifies the need for ethnic‐specific reference equations and presents spirometry references in young Chinese children. Their forced expiratory indices are determined by gender, age, weight and standing height, and standing height is the best anthropometric index to predict all spirometric indices. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Ting F. Leung, Tak C. Liu, Kwok K. Mak, Xuefen Su, Hing Y. Sy, Albert M. Li, Joseph T.F. Lau, Sooky Lum, Gary W.K. Wong Tags: Original Article: Pulmonary Physiology Source Type: research

Quality of spirometry in 5‐to‐8‐year‐old children
ConclusionsOur results support the proposal that a FET ≥3 sec, a BEV ≤80 ml, and repeatability in FEV1 and FVC ≤100 ml, or 10%, be taken into account as elements in quality control for spirometry in children. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Laura Gochicoa‐Rangel, Claudia Vargas‐Domínguez, María Eugenia García‐Mujica, Anaid Bautista‐Bernal, Isabel Salas‐Escamilla, Rogelio Pérez‐Padilla, Luis Torre‐Bouscoulet Tags: Original Article: Pulmonary Physiology Source Type: research

Atopy, cytokine production, and airway reactivity as predictors of pre‐school asthma and airway responsiveness
ConclusionsWhile spirometry and airway responsiveness track longitudinally from early in life, atopy and cytokine production by PBMCs are associated not only with an increased risk of pre‐school asthma, but also lower spirometry and increased airway responsiveness. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Edgar E. Sarria, Rita Mattiello, Weiguo Yao, Valentina Chakr, Christina J. Tiller, Jeffrey Kisling, Rebeka Tabbey, Zhangsheng Yu, Mark H. Kaplan, Robert S. Tepper Tags: Original Article: Asthma Source Type: research

What drives prescribing of asthma medication to preschool wheezing children? A primary care study
Abstract There is limited information on which data primary care pediatricians (PCPs) use to decide whether to prescribe or not maintenance treatment, and what drives prescribing a specific therapy. The study aim was to investigate how prescribing anti‐asthma maintenance treatment to preschool wheezing children is influenced by patient, family, environmental, and PCP characteristics. We conducted a cross‐sectional study at 32 PCPs sites in Campania, Italy. Medical, family, and environmental information of 376 preschool wheezy children, and characteristics of the enrolled PCPs were collected. Main outcome measures of mu...
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: Silvia Montella, Eugenio Baraldi, Dario Bruzzese, Virginia Mirra, Angela Di Giorgio, Francesca Santamaria, Tags: Original Article: Asthma Source Type: research

The role of ultrasound in community‐acquired pneumonia
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: V.A. Caiulo, L. Gargani, S. Caiulo, A. Fisicaro, F Moramarco, G. Latini, E. Picano, G. Mele Tags: Response to Letter Source Type: research

Small airway involvement in cystic fibrosis lung disease: Routine spirometry as an early and sensitive marker
ConclusionsOur data support the use of FEF75 as a more sensitive marker of early CF lung disease than FEV1 and FVC, because abnormalities in FEF75 occur at younger age and FEF75 is diminished more than other parameters. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: E. Marije Bakker, Gerard J.J.M. Borsboom, Els C. van der Wiel‐Kooij, Daan Caudri, Margaret Rosenfeld, Harm A.W.M. Tiddens Tags: Original Article: Cystic Fibrosis Source Type: research

Exhaled breath condensate in pediatric asthma: Promising new advance or pouring cold water on a lot of hot air? A systematic review
ConclusionEBC has the potential to aid diagnosis, and to evaluate the inflammatory status of asthmatic children. Future studies may be able to refine further how best to collect EBC samples, to interpret them, and the technique has the potential to allow repeated sampling which will allow studies of natural history, pathogenesis and response to treatment to be undertaken. Pediatr Pulmonol. © 2013 Wiley Periodicals, Inc.
Source: Pediatric Pulmonology - February 8, 2013 Category: Respiratory Medicine Authors: P.S. Thomas, A.J. Lowe, P. Samarasinghe, C.J. Lodge, Y. Huang, M.J. Abramson, S.C. Dharmage, A. Jaffe Tags: State of the Art Source Type: research

Novel retrospective, respiratory-gating method enables 3D, high resolution, dynamic imaging of the upper airway during tidal breathing.
CONCLUSIONS: Retrospective, respiratory gated imaging of the upper airway has been demonstrated, utilizing a gating algorithm to ensure acquisition over specified ranges of respiratory rate and tidal volume. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. PMID: 23401041 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - February 7, 2013 Category: Radiology Authors: Wagshul ME, Sin S, Lipton ML, Shifteh K, Arens R Tags: Magn Reson Med Source Type: research

Whole-heart coronary MRA with 100% respiratory gating efficiency: Self-navigated three-dimensional retrospective image-based motion correction (TRIM).
CONCLUSION: We have developed a new respiratory motion correction technique for coronary MRA that enables 1 mm(3) isotropic resolution and whole-heart coverage with 7 min of scan time. Further tests on patient population are needed to determine its clinical usage. Magn Reson Med, 2013. © 2013 Wiley Periodicals, Inc. PMID: 23401157 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - February 7, 2013 Category: Radiology Authors: Pang J, Bhat H, Sharif B, Fan Z, Thomson LE, Labounty T, Friedman JD, Min J, Berman DS, Li D Tags: Magn Reson Med Source Type: research

Sudden unexpected death in epilepsy: From the lab to the clinic setting.
This article is part of a Special Issue entitled "Translational Epilepsy Research". PMID: 23402930 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - February 7, 2013 Category: Neurology Authors: Terra VC, Cysneiros R, Cavalheiro EA, Scorza FA Tags: Epilepsy Behav Source Type: research

The Impact of 7-valent Pneumococcal Conjugate Vaccine on Invasive Pneumococcal Disease: A Literature Review.
CONCLUSIONS: The results from this review illustrate that PCV7 has had a significant impact on IPD across all ages through its use in pediatric immunization programs. With the introduction of 13-valent pneumococcal conjugate vaccine (PCV13) further reductions in the incidence of IPD due to the six additional serotypes included, as well as continued protection against IPD due to PCV7 serotypes may be expected. Robust surveillance systems are essential for the evaluation of the impact of PCV13 on all-type IPD and for monitoring the evolution of non-VT IPD. PMID: 23397399 [PubMed - as supplied by publisher]
Source: Advances in Therapy - February 7, 2013 Category: Drugs & Pharmacology Authors: Myint TT, Madhava H, Balmer P, Christopoulou D, Attal S, Menegas D, Sprenger R, Bonnet E Tags: Adv Ther Source Type: research

Are serum levels of immunoglobulin classes and IgG subclasses involved in delayed pulmonary complications induced by sulfur mustard? Sardasht-Iran Cohort Study.
Abstract Respiratory complications are the foremost long term debilitating effects after sulfur mustard toxicity. The underlying immunological mechanisms of sulfur mustard induced lung damage are still poorly understood. The question of the involvement of immunoglobulin classes and subclasses in delayed pulmonary complications induced by SM was addressed in this study as a part of Sardasht-Iran Cohort Study (SICS).In SICS, 372 male participants who were exposed to SM 20years earlier were compared with 128 unexposed age-matched controls. At the time of study (2007), the clinical evaluations and spirometry was perfor...
Source: International Immunopharmacology - February 7, 2013 Category: Allergy & Immunology Authors: Ghazanfari T, Mostafaie A, Yaraee R, Pourfarzam S, Faghihzadeh S, Rezaei A, Mahmoudi M, Vaez-Mahdavi MR, Moaiedmohseni S, Soroush MR, Naghizadeh MM, Faghihzadeh E, Hassan ZM Tags: Int Immunopharmacol Source Type: research

Metabolic fluxes in Schizosaccharomyces pombe grown on glucose and mixtures of glycerol and acetate.
Abstract Growth on glycerol has already been a topic of research for several yeast species, and recent publications deal with the regulatory mechanisms of glycerol assimilation by the fission yeast Schizosaccharomyces pombe. We investigated glycerol metabolism of S. pombe from a physiological point of view, characterizing growth and metabolism on a mixture of glycerol and acetate and comparing it to growth on glucose under respirative growth conditions in chemostat experiments. On glycerol/acetate mixtures, the cells grew with a maximum specific growth rate of 0.11 h(-1) where 46 % of the carbon was channeled int...
Source: Applied Microbiology and Biotechnology - February 7, 2013 Category: Microbiology Authors: Klein T, Heinzle E, Schneider K Tags: Appl Microbiol Biotechnol Source Type: research

Defining a direction: electron transfer and catalysis in Escherichia coli complex II enzymes.
Abstract There are two homologous membrane-bound enzymes in Escherichia coli that catalyze reversible conversion between succinate/fumarate and quinone/quinol. Succinate;ubiquinone reductase (SQR) is a component of aerobic respiratory chains, whereas quinol:fumarate reductase (QFR) utilizes menaquinol to reduce fumarate in a final step of anaerobic respiration. Although, both protein complexes are capable of supporting bacterial growth on either minimal succinate or fumarate media, the enzymes are more proficient in their physiological directions. Here we evaluate factors that may underlie this catalytic bias. ...
Source: Biochimica et Biophysica Acta - February 7, 2013 Category: Biochemistry Authors: Maklashina E, Cecchini G, Dikanov S Tags: Biochim Biophys Acta Source Type: research

Radiographic Fibrosis Score Predicts Survival in Hypersensitivity Pneumonitis.
CONCLUSIONS: Survival in HP was superior to that of IPF patients with similar degrees of radiographic fibrosis. The combination of auscultatory crackles and radiographic reticulation identified HP patients with a particularly poor outcome. PMID: 23392130 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Mooney JJ, Elicker BM, Urbania TH, Agarwal MR, Ryerson CJ, Nguyen ML, Woodruff PG, Jones KD, Collard HR, King TE, Koth LL Tags: Chest Source Type: research

Effects of Experimental Sleep Restriction on Caloric Intake and Activity Energy Expenditure.
CONCLUSIONS: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure nor changes in leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction. TRIAL REGISTRATION: ClinicalTrials.gov number NCT01334788. PMID: 23392199 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Calvin AD, Carter RE, Adachi T, Macedo P, Albuquerque FN, van der Walt C, Bukartyk J, Davison DE, Levine JA, Somers VK Tags: Chest Source Type: research

FDA-MANDATED TRIALS OF LABA SAFETY IN ASTHMA: WILL WE KNOW THE ANSWER?
Abstract ABSTRACT Long acting beta-agonists (LABA) have for two decades been associated with increased asthma death risks in several randomized trials, even when added to inhaled corticosteroids (ICS). In reaction, the FDA recently mandated the manufacturers of LABAs to conduct five large non-inferiority randomized trials of the LABA+ICS combination in 53,000 asthma patients.Three methodological issues in these trials could lead to masking or falsely detecting elevated risks. First, the effect of LABA discontinuation among the many patients already using these drugs at enrollment can result in an underestimation of...
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Suissa S, Ariel A Tags: Chest Source Type: research

The Safety and Feasibility of Interventional Pulmonologists Performing Bedside Percutaneous Endoscopic Gastrostomy Tube Placement.
CONCLUSION: Bedside PEG placement can be performed safely and effectively by trained IP. As percutaneous tracheostomy is currently performed by IP, the ability to perform both PEG and tracheostomy placement at the same time has the potential for decreased costs, anesthesia exposure, procedural times, ventilator times, and ICU days. PMID: 23392239 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Yarmus L, Gilbert C, Lechtzin N, Imad M, Ernst A, Feller-Kopman D Tags: Chest Source Type: research

Trendelenburg Position Does Not Increase Cross-Sectional Area of the Internal Jugular Vein Predictably.
CONCLUSIONS: Trendelenburg positioning augments CSA only modestly, on average, compared with the supine position, and in some patients reduces the CSA. TRIAL REGISTRATION: Clinicaltrials.gov Identifier: NCT01099254. PMID: 23392444 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Nassar B, Deol GR, Ashby A, Collett N, Schmidt GA Tags: Chest Source Type: research

Differences in the pattern of structural abnormalities on CT in patients with cystic fibrosis and pancreatic sufficiency or insufficiency.
CONCLUSIONS In patients with CF-PI, structural lung changes are more severe with upper lobe predominance, prominent bronchiectasis, and bronchial wall thickening versus lower severity and more general distribution of changes in those with CF-PS. PMID: 23392565 [PubMed - as supplied by publisher]
Source: Chest - February 7, 2013 Category: Respiratory Medicine Authors: Simanovsky N, Cohen-Cymberknoh M, Shoseyov D, Gileles-Hillel A, Wilschanski M, Kerem E, Hiller N Tags: Chest Source Type: research