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Respiratory Medicine

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Cross-resistance against RSV entry inhibitors [Microbiology]
In this study, we established a robust high-throughput drug screening protocol by... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - August 19, 2014 Category: Science Authors: Yan, D., Lee, S., Thakkar, V. D., Luo, M., Moore, M. L., Plemper, R. K. Tags: PNAS Plus Source Type: research

Activation-induced Cell Death Drives Profound Lung CD4(+) T Cell Depletion in HIV-associated COPD.
Abstract Rationale: As overall survival improves, individuals with HIV infection become susceptible to other chronic diseases, including accelerated COPD. Objective: To determine whether individuals with HIV-associated COPD exhibit dysregulated lung mucosal T-cell immunity compared to controls. Methods: Using flow cytometry, we evaluated peripheral blood and lung mucosal T-cell immunity in 14 HIV+COPD+, 13 HIV+COPD- and 7 HIV-COPD+ individuals. Measurements and Main Results: HIV+COPD+ individuals demonstrated profound CD4+ T-cell depletion with reduced CD4:CD8 T-cell ratios in BAL-derived lung mononuclear cells (LM...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Popescu I, Drummond MB, Gama L, Coon T, Merlo CA, Wise RA, Clements JE, Kirk GD, McDyer JF Tags: Am J Respir Crit Care Med Source Type: research

Short and Long-term Effects of Ambient Ozone and Fine Particulate Matter on the Respiratory Health of COPD Subjects.
Abstract Abstract To date, no study has evaluated the short and long-term effects air pollution exposure on emphysematous subjects who have undergone lung volume reduction surgery (LVRS). Data from the NETT study (1998-2003) included 1218 subjects, aged 39-84. Daily values of ambient fine particulate matter (PM2.5) and ozone were obtained. Mixed effects models tested the association between short and long-term pollutant concentrations and changes in pulmonary function. Cumulative air pollution exposure was strongly associated with worsened respiratory function and symptoms. Mean PM2.5 was associated with poorer lun...
Source: Archives of Environmental and Occupational Health - August 19, 2014 Category: Environmental Health Authors: Kariisa M, Foraker R, Pennell M, Buckley T, Diaz P, Criner GJ, Wilkins JR Tags: Arch Environ Occup Health Source Type: research

Geobacter soli sp. nov., a novel dissimilatory Fe(III)-reducing bacterium isolated from a forest soil in South China.
Abstract A novel Fe(III)-reducing bacterium, designated GSS01(T), was isolated using a liquid medium containing acetate and ferrihydrite as electron donor and electron acceptor, respectively, from a forest soil sample. Strain GSS01(T) was strictly anaerobic, Gram-negative, motile, non-spore-forming, and slightly curved rod-shaped. Growth occurred at 16-40 (o)C and optimally at 30 (o)C. The DNA G+C content was 60.9 mol%. The major respiratory quinone was MK-8. The major fatty acids were C16:0, C18:0 and C16:1ω7c/C16:1ω6c. Strain GSS01(T) was able to grow with ferrihydrite, Fe(III) citrate, Mn(IV), sulfur, nitrate ...
Source: International Journal of Systematic and Evolutionary Microbiology - August 19, 2014 Category: Microbiology Authors: Zhou S, Yang G, Lu Q, Wu M Tags: Int J Syst Evol Microbiol Source Type: research

Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells.
Abstract Our previous studies showed that cigarette smokers who are exposed to wood smoke (WS) are at an increased risk for chronic bronchitis and reduced lung function. The present study was to determine the mechanisms for WS-induced adverse effects. We studied the effect of wood smoke exposure using 4 cohorts of mice. C57Bl/6 were exposed for 4 or 12 wk to filtered air (FA), to 10 mg/m3 wood smoke (WS) for 2h/d, to 250 mg/m3 cigarette smoke (CS) for 6 h/d, or to CS followed by WS (CW). Inflammation was absent in the FA and WS groups, but enhanced by 2-fold in the bronchoalveolar lavage (BAL) of the CW compared to...
Source: American Journal of Respiratory Cell and Molecular Biology - August 19, 2014 Category: Molecular Biology Authors: Awji EG, Chand H, Bruse S, Smith KR, Colby JK, Mebratu Y, Levy BD, Tesfaigzi Y Tags: Am J Respir Cell Mol Biol Source Type: research

Impaired Hypercarbic and Hypoxic Responses from Developmental Loss of Cerebellar Purkinje Neurons: Implications for Sudden Infant Death Syndrome.
Abstract Impaired responsivity to hypercapnia or hypoxia is commonly considered a mechanism of failure in sudden infant death syndrome (SIDS). The search for deficient brain structures mediating flawed chemosensitivity typically focuses on medullary regions; however, a network that includes Purkinje cells of the cerebellar cortex and its associated cerebellar nuclei also helps mediate responses to carbon dioxide (CO2) and oxygen (O2) challenges and assists integration of cardiovascular and respiratory interactions. Although cerebellar nuclei contributions to chemoreceptor challenges in adult models are well describ...
Source: Cerebellum - August 19, 2014 Category: Neuroscience Authors: Calton M, Dickson P, Harper RM, Goldowitz D, Mittleman G Tags: Cerebellum Source Type: research

Cardiomegaly Is a Significant Predictor of Postoperative Atelectasis following Left Upper Superior Segmentectomy.
Conclusions Preoperative CTR was related to atelectasis of the lingular segment. One of the advantages of segmentectomy is that it enables the postoperative preservation of respiratory function. However, in patients with cardiomegaly, respiratory function following LUSS may be preserved less than expected. PMID: 25136944 [PubMed - as supplied by publisher] (Source: The Thoracic and Cardiovascular Surgeon)
Source: The Thoracic and Cardiovascular Surgeon - August 19, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Miyasaka Y, Suzuki K, Oh S, Takamochi K Tags: Thorac Cardiovasc Surg Source Type: research

Inhibition of Akt Phosphorylation Diminishes Mitochondrial Biogenesis Regulators, Tricarboxylic Acid Cycle Activity and Exacerbates Recognition Memory Deficit in Rat Model of Alzheimer's Disease.
Abstract 3-Methyladenine (3-MA), as a PI3K inhibitor, is widely used for inhibition of autophagy. Inhibition of PI3K class I leads to inhibition of Akt phosphorylation, a central molecule involved in diverse arrays of intracellular cascades in nervous system. Accordingly, in the present study, we aimed to determine the alterations of specific mitochondrial biogenesis markers and mitochondrial function in 3-MA-injected rats following amyloid beta (Aβ) insult. Our data revealed that inhibition of Akt phosphorylation downregulates master regulator of mitochondrial biogenesis, peroxisome proliferator-activated recepto...
Source: Cellular and Molecular Neurobiology - August 19, 2014 Category: Cytology Authors: Shaerzadeh F, Motamedi F, Khodagholi F Tags: Cell Mol Neurobiol Source Type: research

Smoking decreases structural and functional resilience in the subgingival ecosystem.
CONCLUSIONS: The ability of the subgingival microbiome to 'reset' itself following episodes of disease is decreased in smokers, thereby lowering the resilience of the ecosystem and decreasing its resistance to future disease. This article is protected by copyright. All rights reserved. PMID: 25139209 [PubMed - as supplied by publisher] (Source: Journal of Clinical Periodontology)
Source: Journal of Clinical Periodontology - August 19, 2014 Category: Dentistry Authors: Joshi V, Matthews C, Aspiras M, de Jager M, Ward M, Kumar P Tags: J Clin Periodontol Source Type: research

The mucosal expression pattern of interferon-ε in rhesus macaques.
We report for the first time the detection of IFN-ε expression in situ in the lung, foreskin, vaginal, cervical, and small and large intestinal mucosae of rhesus macaques. We found that the expression of IFN-ε was exclusive to the epithelial cells in all of the aforementioned mucosal tissues. Furthermore, the macaque IFN-ε sequence in this study revealed that macaque IFN-ε is highly conserved among human and other nonhuman primates. Lastly, SIV rectal infection did not significantly alter the expression of IFN-ε in rectal mucosae. Together, these findings indicate that IFN-ε may function as the first line of defense ...
Source: Journal of Leukocyte Biology - August 19, 2014 Category: Hematology Authors: Demers A, Kang G, Ma F, Lu W, Yuan Z, Li Y, Lewis M, Kraiselburd EN, Montaner L, Li Q Tags: J Leukoc Biol Source Type: research

Mechanisms of exercise intolerance in Global Initiative for Chronic Obstructive Lung Disease grade 1 COPD.
Abstract The purpose of this study was to determine if a dissociation existed between respiratory drive, as estimated by diaphragmatic electromyography (EMGdi), and its pressure-generating capacity during exercise in mild chronic obstructive pulmonary disease (COPD) and whether this, if present, had negative sensory consequences. Subjects meeting spirometric criteria for mild COPD (n = 16) and age and sex-matched controls (n = 16) underwent detailed pulmonary function testing and a symptom limited cycle test while detailed ventilatory, sensory and respiratory mechanical responses were measured. Compared with contro...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Guenette JA, Chin RC, Cheng S, Dominelli PB, Raghavan N, Webb KA, Neder JA, O'Donnell DE Tags: Eur Respir J Source Type: research

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: a cohort study.
PMID: 25142486 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Wilson E, McKeever T, Hargadon B, Hearson G, Anderson J, Hodgson D, Bailey H, Meakin G, Thomas M, Pavord ID, Harrison T, Shaw D Tags: Eur Respir J Source Type: research

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.
Abstract Previously, we demonstrated concordance in differentially expressed genes in sarcoidosis blood and lung, implicating shared dysfunction of specific immune pathways. In the present study, we hypothesised that expression levels of candidate genes in sarcoidosis blood could predict and track with disease outcomes longitudinally. We applied Ingenuity Pathway Analysis to a cross-sectional derivation microarray dataset (n = 38) to identify canonical pathways and candidate genes associated with sarcoidosis. In a separate longitudinal sarcoidosis cohort (n = 103), we serially measured 48 candidate gene transcripts...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Su R, Li MM, Bhakta NR, Solberg OD, Darnell EP, Ramstein J, Garudadri S, Ho M, Woodruff PG, Koth LL Tags: Eur Respir J Source Type: research

Ground-based walking training improves quality of life and exercise capacity in COPD.
This study was designed to determine the effect of ground-based walking training on health-related quality of life and exercise capacity in people with chronic obstructive pulmonary disease (COPD). People with COPD were randomised to either a walking group that received supervised, ground-based walking training two to three times a week for 8-10 weeks, or a control group that received usual medical care and did not participate in exercise training. 130 out of 143 participants (mean±sd age 69±8 years, forced expiratory volume in 1 s 43±15% predicted) completed the study. Compared to the control group, the walking group d...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Wootton SL, Ng LW, McKeough ZJ, Jenkins S, Hill K, Eastwood PR, Hillman DR, Cecins N, Spencer LM, Jenkins C, Alison JA Tags: Eur Respir J Source Type: research

Ageing and the epidemiology of multimorbidity.
This article reviews the relationship between ageing and chronic respiratory disease, and also how certain chronic diseases cluster with others, either on the basis of underlying risk factors, complication of the primary disease or other factors, such as an increased state of inflammation. While death is inevitable, disabling chronic illnesses are not. Better understanding of how individuals can age healthily without the development of multiple chronic illnesses should lead to an improved global quality of life. PMID: 25142482 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Divo MJ, Martinez CH, Mannino DM Tags: Eur Respir J Source Type: research

Quantifying comorbidity in individuals with chronic obstructive pulmonary disease: a population study.
Abstract Chronic obstructive pulmonary disease (COPD) has been associated with many types of comorbidity. We aimed to quantify the real world impact of COPD on lower respiratory tract infection, cardiovascular disease, diabetes, psychiatric disease, musculoskeletal disease and cancer, and their impact on COPD through health services. A population study using health administrative data from Ontario, Canada, in 2008-2012 was conducted. Absolute and adjusted relative rates of ambulatory care visits, emergency department visits and hospitalisations for the comorbidities of interest in people with and without COPD were ...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Gershon AS, Mecredy GC, Guan J, Victor JC, Goldstein R, To T Tags: Eur Respir J Source Type: research

Effect of whole body hypothermia on inflammation and surfactant function in asphyxiated neonates.
PMID: 25142478 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: De Luca D, Vázquez-Sánchez S, Minucci A, Echaide M, Piastra M, Conti G, Capoluongo ED, Pérez-Gil J Tags: Eur Respir J Source Type: research

Microvascular disease in chronic thromboembolic pulmonary hypertension: a role for pulmonary veins and systemic vasculature.
Abstract Limited numbers of operated patients with chronic thromboembolic pulmonary hypertension (CTEPH) are refractory to pulmonary endarterectomy (PEA) and experience persistent pulmonary hypertension (PH). We retrospectively assessed lung histology available from nine patients with persistent PH (ineffective PEA (inPEA) group) and from eight patients transplanted for distal CTEPH inaccessible by PEA (noPEA group). Microscopically observed peculiarities were compared with the histology of a recently developed CTEPH model in piglets. Pre-interventional clinical/haemodynamic data and medical history of patients fro...
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Dorfmüller P, Günther S, Ghigna MR, Thomas de Montpréville V, Boulate D, Paul JF, Jaïs X, Decante B, Simonneau G, Dartevelle P, Humbert M, Fadel E, Mercier O Tags: Eur Respir J Source Type: research

Voluntary Is Better Than Involuntary Cough Peak Flow for Predicting Re-Intubation After Scheduled Extubation in Cooperative Subjects.
CONCLUSIONS: V-CPF is noninvasive. It is much more accurate than IV-CPF as a predictor of re-intubation in cooperative patients because the IV-CPF may underestimate cough strength in patients with high V-CPF. However, it is unclear which is optimal for use in uncoop-erative patients. PMID: 25140034 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Duan J, Liu J, Xiao M, Yang X, Wu J, Zhou L Tags: Respir Care Source Type: research

Open-Mouthpiece Ventilation Versus Nasal Mask Ventilation in Subjects With COPD Exacerbation and Mild to Moderate Acidosis: A Randomized Trial.
CONCLUSIONS: Open mouthpiece ventilation is a useful technique and may prevent further deterioration of gas exchange in COPD patients with mild to moderate acidosis (similar to traditional NIV delivered by a nasal mask). PMID: 25140033 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Nicolini A, Santo M, Ferrari-Bravo M, Barlascini C Tags: Respir Care Source Type: research

Effects of an Educational Intervention of Physical Activity for Children and Adolescents With Cystic Fibrosis: A Randomized Controlled Trial.
CONCLUSIONS: Verbal and written guidelines for aerobic exercise, together with supervision over the telephone, had a positive impact on the self-reported regular physical exercise practice of children and adolescents. However, no improvement was found in lung function and maximum exercise capacity or domains of the quality of life questionnaire. PMID: 25140032 [PubMed - as supplied by publisher] (Source: Respiratory Care)
Source: Respiratory Care - August 19, 2014 Category: Respiratory Medicine Authors: Hommerding PX, Baptista RR, Makarewicz GT, Schindel CS, Donadio MV, Pinto LA, Marostica PJ Tags: Respir Care Source Type: research

Inhibition of porcine reproductive and respiratory syndrome virus by specific siRNA targeting Nsp9 gene.
Abstract To screen siRNAs for effectively inhibiting the replication of porcine reproductive and respiratory syndrome virus (PRRSV).Four pairs of siRNA targeting Nsp9 gene of PRRSV and one non-efficient pair used as control were designed, synthesized and cloned into pSilencer4.1-CMV neo, designated as pSi-294, pSi-367, pSi-409, pSi-1488, pSi-Ctr. The recombinant plasmids were transfected into Marc-145 cells and infected with PRRSV 24h post transfection. Subsequently, IFA, real-time PCR, TCID50 and western blot were used for evaluating the inhibitory effect of the siRNA. IFA and western-blot results showed that pSi-...
Source: Infection, Genetics and Evolution - August 19, 2014 Category: Genetics & Stem Cells Authors: Xie J, Zhou H, Cui J, Chen Y, Deng S, Zhou P, Su S, Zhang G Tags: Infect Genet Evol Source Type: research

Acute toxicity of karlotoxins to mice.
In this study, the acute effects of 3 pure karlotoxin analogs (KmTx 1, KmTx 3 and KmTx 2) have been examined in mice. Transient lethargy and increased respiratory rates were observed soon after dosing with the karlotoxins by intraperitoneal injection, but no deaths were recorded in animals dosed with KmTx 2 at up to 500 μg/kg or with KmTx 1 or KmTx 3 at up to 4,000 μg/kg. Animals dosed intraperitoneally with KmTx 1 and KmTx 3 at 4,000 μg/kg showed a pronounced decrease in food and water intake, lasting 3-4 days after dosing, accompanied by a significant decrease in body weight. After this time, the lost body weight was ...
Source: Toxicon - August 19, 2014 Category: Toxicology Authors: Place AR, Munday R, Munday JS Tags: Toxicon Source Type: research

Effects of different inoculation routes on the parasitic sites of Cryptosporidium baileyi infection in chickens.
In this study, SEM, histological, semi-quantitative PCR, and nested PCR techniques were used to explore the impact of different inoculation routes on sites of C. baileyi infection in chickens. Results showed that inoculation with sporozoites or oocysts via the rectum was an effective means of causing infection. This may provide an important reference for the development of the transfection system of C. baileyi in chickens. Numerous endogenous stages of C. baileyi were observed in the bursas of Fabricius (BF) and cloacas of chickens inoculated with sporozoites or oocysts via the rectum, but no parasite was seen in the trach...
Source: Experimental Parasitology - August 19, 2014 Category: Parasitology Authors: Yuan L, Yan W, Wang T, Qian W, Ding K, Zhang L, Han L, Shao X Tags: Exp Parasitol Source Type: research

[Foreign body aspiration in children: Algerian experience of 2624 patients.]
CONCLUSION: Foreign body aspiration is a real public health problem in Algeria. Its frequency is high enough to alert health authorities. The characteristics of these domestic events are those of intermediate income countries with a wide range of foreign bodies. The best way to manage this is an early diagnosis and rigid bronchoscopy removal under general anesthesia used by fully trained staff. The prevention of this domestic accident should consider the population's lifestyle and cultural habits for maximum efficacy. PMID: 25149659 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - August 19, 2014 Category: Pediatrics Authors: Boufersaoui A, Smati L, Benhalla KN, Boukari R, Smail S, Anik K, Aouameur R, Chaouche H, Baghriche M Tags: Arch Pediatr Source Type: research

A colorimetric immunoassay for respiratory syncytial virus detection based on gold nanoparticles-graphene oxide hybrids with mercury-enhanced peroxidase-like activity
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC05155F, CommunicationLei Zhan, Chun Mei Li, Wen Bi Wu, Cheng Zhi HuangA novel colorimetric immunoassay for detection of respiratory syncytial virus (RSV) was developed based on mercury-stimulated peroxidase-like activity of gold nanoparticles-graphene composites (AuNPs-GO).To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - August 18, 2014 Category: Chemistry Authors: Lei Zhan Source Type: research

High risk of adult asthma following severe wheezing in early life
Conclusion: Subjects with severe early wheezing have a 10‐fold increase in the risk of adult asthma compared to an age‐matched control group, adjusted for allergic rhinitis, gender, smoking and heredity. Pediatr Pulmonol. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - August 18, 2014 Category: Respiratory Medicine Authors: Emma Goksör, Mainor Åmark, Bernt Alm, Linda Ekerljung, Bo Lundbäck, Göran Wennergren Tags: Original Article: Epidemiology Source Type: research

Mitochondrial DNA (mtDNA) variants in the European haplogroups HV, JT, and U do not have a major role in schizophrenia
This study was performed in three steps: (1) identification of pathogenic mutations and variants in 14 schizophrenia patients with an apparent maternal inheritance of the disease by sequencing the entire mtDNA; (2) case‐control association study of 23 variants identified in step 1 (16 missense, 3 rRNA, and 4 tRNA variants) in 495 patients and 615 controls, and (3) analyses of the associated variants according to the clinical, psychopathological, and neuropsychological characteristics and according to the oxidative and enzymatic activities of the mitochondrial respiratory chain. We did not identify pathogenic mtDNA mutati...
Source: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics - August 18, 2014 Category: Genetics & Stem Cells Authors: Helena Torrell, Antonio Salas, Nerea Abasolo, Constanza Morén, Glòria Garrabou, Joaquín Valero, Yolanda Alonso, Elisabet Vilella, Javier Costas, Lourdes Martorell Tags: Research Article Source Type: research

Sleep and cognitive performance: The role of income and respiratory sinus arrhythmia reactivity
ABSTRACT A health disparities view suggests that low family income status acts as a risk factor for poor cognitive functioning. A biosystems view suggests that poor sleep and poor stress response system functioning are also risk factors. These views are rarely integrated to test multiplicative risk or protective effects from social–cultural and biological variables. We investigated interactions among familial income, children's sleep and respiratory sinus arrhythmia reactivity (RSA reactivity, indexing parasympathetic nervous system reactivity) in the prediction of cognitive performance of school‐aged children. Partici...
Source: Developmental Psychobiology - August 18, 2014 Category: Psychiatry & Psychology Authors: Lori Staton, J. Benjamin Hinnant, Joseph Buckhalt, Mona El‐Sheikh Tags: Research Article Source Type: research

Frequent cough in unsatisfactory controlled asthma – results from the population-based West Sweden Asthma Study
Conclusions: Approximately 60% of asthmatics from this population-based study had insufficiently controlled asthma and persistent complaints, despite a high use of asthma medications. These self-reported symptoms were supported by clinical examination data. Increased cough frequency is an indicator of a more severe and difficult to control disease and should be considered when asthma is characterized. (Source: BioMed Central)
Source: BioMed Central - August 18, 2014 Category: Journals (General) Authors: Roxana MinchevaLinda EkerljungAnders BjergMalin AxelssonTodor A PopovBo LundbäckJan Lötvall Source Type: research

Frequent cough in unsatisfactory controlled asthma ¿ results from the population-based West Sweden Asthma Study
Conclusions: Approximately 60% of asthmatics from this population-based study had insufficiently controlled asthma and persistent complaints, despite a high use of asthma medications. These self-reported symptoms were supported by clinical examination data. Increased cough frequency is an indicator of a more severe and difficult to control disease and should be considered when asthma is characterized. (Source: Respiratory Research)
Source: Respiratory Research - August 18, 2014 Category: Respiratory Medicine Authors: Roxana MinchevaLinda EkerljungAnders BjergMalin AxelssonTodor PopovBo LundbäckJan Lötvall Source Type: research

Flow-controlled expiration: a novel ventilation mode to attenuate experimental porcine lung injury
Conclusions The newly developed FLEX mode is able to attenuate experimental lung injury. FLEX could provide a novel means of lung-protective ventilation. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - August 18, 2014 Category: Anesthesiology Authors: Goebel, U., Haberstroh, J., Foerster, K., Dassow, C., Priebe, H.- J., Guttmann, J., Schumann, S. Tags: Respiration And The Airway Source Type: research

High-frequency jet ventilation shortened the duration of gas embolization during laparoscopic liver resection in a porcine model
Conclusion HFJV shortened the mean duration of GE during LLR and was a feasible ventilation method during the procedure. Individual physiological responses to GE were unpredictable. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - August 18, 2014 Category: Anesthesiology Authors: Fors, D., Eiriksson, K., Waage, A., Arvidsson, D., Rubertsson, S. Tags: Respiration And The Airway Source Type: research

Preliminary development and evaluation of the support system for care of mechanically ventilated patients
Conclusions The SCMVP can facilitate rapid and successful recognition of the site of leak in a respiratory circuit in a simulation environment. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - August 18, 2014 Category: Anesthesiology Authors: Maruyama, K., Morohashi, S., Fukakura, Y., Takeuchi, H., Miyaji, T., Tsuji, T., Hasegawa, T., Eguchi, K., Usuda, Y., Andoh, T. Tags: Respiration And The Airway Source Type: research

Anaesthetic conserving device AnaConDa(R): dead space effect and significance for lung protective ventilation
Conclusions An ACD causes a dead space effect larger than its internal volume due to reflection of CO2, which is attenuated but not abolished by sevoflurane administration. CO2 reflection from the ACD limits its use with low tidal volume ventilation, such as with lung protection ventilation strategies. Clinical trial registration Clinical Trials NCT01699802. (Source: British Journal of Anaesthesia)
Source: British Journal of Anaesthesia - August 18, 2014 Category: Anesthesiology Authors: Sturesson, L. W., Bodelsson, M., Jonson, B., Malmkvist, G. Tags: Respiration And The Airway Source Type: research

Tasmanian Aborigines step up to health: evaluation of a cardiopulmonary rehabilitation and secondary prevention program
Conclusion: A cardiopulmonary program, which included exercise and education and met national guidelines, was designed and delivered specifically for the Aboriginal community. It increased participation in rehabilitation by Aborigines with, or at high risk of, established disease and led to positive changes in health behaviours, functional exercise capacity and health related quality of life. (Source: BMC Health Services Research)
Source: BMC Health Services Research - August 18, 2014 Category: Journals (General) Authors: Maureen DaveyWendy MooreJulia Walters Source Type: research

Wheat-dependent exercise-induced anaphylaxis: a retrospective case review from a tertiary hospital
Conclusions With the emergence of wheat allergy in East Asian countries, WDEIA has become an important condition for physicians and Singapore is no exception. Under-recognition combined with life-threatening symptoms warrants better public awareness measures. In addition, further studies are necessary to identify possible unique genetic and environmental exposures that could explain the inter-regional differences of WDEIA. (Source: Postgraduate Medical Journal)
Source: Postgraduate Medical Journal - August 18, 2014 Category: Journals (General) Authors: Thalayasingam, M., Allameen, N. A., Soh, J. Y., Bigliardi, P., Van Bever, H., Shek, L. P.-C. Tags: Immunology (including allergy), Drugs: cardiovascular system, Dermatology Original article Source Type: research