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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Direct Growth Inhibition Assay of Total Airborne Fungi with Application of Biocide-treated Malt Extract Agar
Publication date: Available online 20 July 2015 Source:MethodsX Author(s): Chin Ming Er, N.M. Sunar, A.M. Leman, N. Othman Indoor air pollution by airborne fungi has risen to become a common issue all over the world and it is hazardous to indoor occupants’ health as it is associated with a series of respiratory-related and skin-related diseases. Selected bioactive compounds from the food industry have been suggested to be effective against individual fungus isolated from indoor environment. However, the techniques used to evaluate these compounds were lengthy and unsuitable against total airborne fungi. Therefore, ...
Source: MethodsX - July 20, 2015 Category: Science Source Type: research

The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension.
CONCLUSIONS: Combined IL-4 and IL-13 deficiency is required for protection against TGF-β-induced pulmonary vascular disease after Schistosoma exposure, and targeted inhibition of this pathway is a potential novel therapeutic approach for patients with schistosomiasis-associated PAH. PMID: 26192556 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 20, 2015 Category: Respiratory Medicine Authors: Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Rodriguez Garcia A, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB Tags: Am J Respir Crit Care Med Source Type: research

Characteristics and Outcomes of Eligible Non-Enrolled Patients in a Mechanical Ventilation Trial of Acute Respiratory Distress Syndrome.
CONCLUSIONS: Non-enrollment was common, with approximately 1 ENE patient for every randomized patient. Our study suggests that enrollment in trials of mechanical ventilation may be associated with improved outcomescompared with standard care and highlights the need for prospective tracking and transparent reporting of ENE patients as part of trial management. PMID: 26192398 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - July 20, 2015 Category: Respiratory Medicine Authors: Arabi YM, Cook DJ, Zhou Q, Smith O, Hand L, Turgeon AF, Matte A, Mehta S, Graham R, Brierley K, Adhikari NK, Meade MO, Ferguson ND, Canadian Critical Care Trials Group Tags: Am J Respir Crit Care Med Source Type: research

CD11b(+) Mononuclear Cells Mitigate Hyperoxia-induced Lung Injury in Neonatal Mice.
Abstract Bronchopulmonary dysplasia (BPD) is a common consequence of life-saving interventions for infants born with immature lungs. Resident tissue myeloid cells regulate lung pathology, but their role in BPD is poorly understood. To determine the role of lung interstitial myeloid cells in neonatal responses to lung injury, we exposed newborn mice to hyperoxia, a neonatal mouse lung injury model with features of human BPD. In newborn mice raised in normoxia, we identified a CD45+F4/80+CD11b+CD71+ population of cells in lungs of neonatal mice present in significantly greater percentages than in adult mice. In respo...
Source: Am J Respir Cell Mol... - July 20, 2015 Category: Respiratory Medicine Authors: Eldredge LC, Treuting PM, Manicone AM, Ziegler SF, Parks WC, McGuire JK Tags: Am J Respir Cell Mol Biol Source Type: research

Presentations to Alberta Emergency Departments for Asthma: A Time Series Analysis.
CONCLUSIONS: Rates of ED presentations for asthma have been declining in this province during the past decade. The reasons for this decline warrant further exploration. The SARIMA models quantified the temporal patterns and may be helpful for planning research and health care service needs. PMID: 26194859 [PubMed - as supplied by publisher] (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - July 20, 2015 Category: Emergency Medicine Authors: Rosychuk RJ, Youngson E, Rowe BH Tags: Acad Emerg Med Source Type: research

Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond.
Abstract Both severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are zoonotic pathogens that crossed the species barriers to infect humans. The mechanism of viral interspecies transmission is an important scientific question to be addressed. These coronaviruses contain a surface-located spike (S) protein that initiates infection by mediating receptor-recognition and membrane fusion and is therefore a key factor in host specificity. In addition, the S protein needs to be cleaved by host proteases before executing fusion, making these proteases a secon...
Source: Trends in Microbiology - July 20, 2015 Category: Microbiology Authors: Lu G, Wang Q, Gao GF Tags: Trends Microbiol Source Type: research

Enhanced immunogenicity of a respiratory syncytial virus (RSV) F subunit vaccine formulated with the adjuvant GLA-SE in cynomolgus macaques.
This study indicates that a GLA-SE adjuvanted RSV sF vaccine induces robust humoral and Th1-biased cellular immunity in non-human primates and may benefit human populations at risk for RSV disease. PMID: 26206269 [PubMed - as supplied by publisher] (Source: Vaccine)
Source: Vaccine - July 20, 2015 Category: Allergy & Immunology Authors: Patton K, Aslam S, Shambaugh C, Lin R, Heeke D, Frantz C, Zuo F, Esser MT, Paliard X, Lambert SL Tags: Vaccine Source Type: research

New dry powders for inhalation containing temozolomide-based nanomicelles for improved lung cancer therapy.
Abstract Besides the numerous advantages of a chemotherapy administered by the inhalation route for lung cancer therapy, dry powder for inhalation (DPI) offers many advantages compared to other techniques and seems to be a technique that is well-adapted to an anticancer treatment. DPI formulations were developed using the cytotoxic drug temozolomide and a new folate-grafted self-assembling copolymer, a conjugate of three components, folate-polyethylene glycol-hydrophobically-modified dextran (F-PEG-HMD). F-PEG-HMD was synthesized using carbodiimide-mediated coupling chemistry in three main steps. F-PEG-HMD was char...
Source: International Journal of Oncology - July 20, 2015 Category: Cancer & Oncology Authors: Rosière R, Gelbcke M, Mathieu V, Van Antwerpen P, Amighi K, Wauthoz N Tags: Int J Oncol Source Type: research

Should we treat chronic obstructive pulmonary disease as a cardiovascular disease?
Expert Review of Respiratory Medicine, Ahead of Print. (Source: Expert Review of Respiratory Medicine)
Source: Expert Review of Respiratory Medicine - July 19, 2015 Category: Respiratory Medicine Tags: article Source Type: research

Update of the results of the Spanish branch of the European randomized study on screening for prostate cancer (ERSPC)
Conclusions PC screening results in a shifting of the diagnosis toward earlier stages. Nevertheless, we have not demonstrated a benefit in terms of overall or cancer-specific survival after more than 15 years of follow-up. The low mortality from this disease in our community could be one of the main factors that explain these results. (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - July 19, 2015 Category: Urology & Nephrology Source Type: research

Characterisation of the Equine adenovirus 2 genome
In this study the complete genome sequence of EAdV-2 is reported. As expected, genes common to the adenoviruses were identified. Phylogenetic reconstructions using selected EAdV-2 genes confirmed the classification of this virus within the Mastadenovirus genus, and supported the hypothesis that EAdV-2 and EAdV-1 have evolved from separate lineages within the adenoviruses. One spliced open reading frame was identified that encoded for a polypeptide with high similarity to the pIX and E1b_55K adenovirus homologues and was designated pIX_E1b_55K. In addition to this fused version of E1b_55K, a separate E1b_55K encoding gene w...
Source: Veterinary Microbiology - July 19, 2015 Category: Veterinary Research Source Type: research

Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: involving TLR4 and its downstream signaling pathway
Publication date: Available online 19 July 2015 Source:Respiratory Physiology & Neurobiology Author(s): Yan Deng, Xiao Yuan, Xue-ling Guo, Die Zhu, Yue-ying Pan, Hui-guo Liu Hippocampal neuronal damage is critical for the initiation and progression of neurocognitive impairment accompanied obstructive sleep apnea syndrome (OSAS). Toll-like receptor 4(TLR4) plays an important role in the development of several hippocampus-related neural disorders. Atorvastatin was reported beneficially regulates TLR4. Here, we examined the effects of atorvastatin on hippocampal injury caused by chronic intermittent hypoxia (C...
Source: Respiratory Physiology and Neurobiology - July 19, 2015 Category: Respiratory Medicine Source Type: research

Efficacy of atorvastatin on hippocampal neuronal damage caused by chronic intermittent hypoxia: involving TLR4 and its downstream signaling pathway.
Abstract Hippocampal neuronal damage is critical for the initiation and progression of neurocognitive impairment accompanied obstructive sleep apnea syndrome (OSAS). Toll-like receptor 4(TLR4) plays an important role in the development of several hippocampus-related neural disorders. Atorvastatin was reported beneficially regulates TLR4. Here, we examined the effects of atorvastatin on hippocampal injury caused by chronic intermittent hypoxia (CIH), the most characteristic pathophysiological change of OSAS. Mice were exposed to intermittent hypoxia with or without atorvastatin for 4 weeks. Cell damage, the expressi...
Source: Respiratory Care - July 19, 2015 Category: Respiratory Medicine Authors: Deng Y, Yuan X, Guo XL, Zhu D, Pan YY, Liu HG Tags: Respir Physiol Neurobiol Source Type: research

Impact of Left Ventricular Hypertrophy on Survival in Chronic Obstructive Pulmonary Disease
Conclusions The presence of LVH, demonstrated by elevated left ventricular mass index is associated with a significantly increased risk of mortality in COPD patients. Therapeutic interventions are required to address this important modifiable risk factor in COPD patients. (Source: Lung)
Source: Lung - July 18, 2015 Category: Respiratory Medicine Source Type: research

Lymphangioleiomyomatosis: New Treatment Perspectives
Abstract Lymphangioleiomyomatosis (LAM) is a rare multisystem disease, occurs in women, usually premenopausal, caused by the proliferation of neoplastic smooth muscle-derived cells. Mutations in the tuberous sclerosis complex genes, lead to the activation of mammalian target of rapamycin kinase (mTOR), results in proliferation of LAM cells, its increasing motility, and survival. Polycystic lung destruction, extensive involvement of lymphatic channels, chylothorax, chyloperitoneum, and renal angiomyolipomas can develop in LAM patients. The new, promising treatment strategies have been recently introduced due to di...
Source: Lung - July 18, 2015 Category: Respiratory Medicine Source Type: research

The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis
Conclusion Our meta-analysis supports the hypothesis that the specific HLA-DQB1 may be regarded as a marker of real worth for predicting the risk of developing TB. The same result was shown in Asian population. (Source: Lung)
Source: Lung - July 18, 2015 Category: Respiratory Medicine Source Type: research

Retraction Note to: Coexpression of HSP47 Gene and Type I and Type III Collagen Genes in LPS-Induced Pulmonary Fibrosis in Rats
(Source: Lung)
Source: Lung - July 18, 2015 Category: Respiratory Medicine Source Type: research

Community-acquired Pneumonia and its Complications
Abstract Community-acquired pneumonia (CAP) remains a major cause of morbidity and mortality worldwide in developing and developed countries, and its incidence is highest among children less than 5-y-old. Over the last five years, several international and local guidelines have been updated with new evidence concerning the epidemiology, etiology, pathogenesis, treatment and prevention of pediatric CAP, but there are still several major problems that need to be standardised. The aim of this review is to consider the available data concerning the termination, epidemiology, microbiology and pathogenesis, clinical fe...
Source: Indian Journal of Pediatrics - July 18, 2015 Category: Pediatrics Source Type: research

Nonsyndromic Juvenile Myelomonocytic Leukemia With PTPN11 Mutation in a 9-Year-old Girl
A 9.5-year-old girl with malaise, fever, massive hepatosplenomegaly, anemia, leukocytosis (37.9×109/L), monocytosis (1.48×109/L), and thrombocytopenia is presented. Hemoglobin F was increased (18%). Bone marrow erythroid/myeloid ratio was 40/1 with 7% myeloblast and 5% monocyte suggesting erythroleukemia or juvenile myelomonocytic leukemia (JMML). The patient had a fulminant course with respiratory compromise and died in 2 weeks before heterozygous somatic mutation in the PTPN11 gene was shown. JMML must be considered also in the patients older than 6 years. A cytopenic phase may precede JMML. Leucocytosis may be transie...
Source: Journal of Pediatric Hematology Oncology - July 18, 2015 Category: Hematology Tags: Clinical and Laboratory Observations Source Type: research

Respiratory Failure in Children With Hemato-oncological Diseases Admitted to the PICU: A Single-center Experience
We present a retrospective chart review of children admitted to our PICU because of RF (January 2006 to December 2010). The aims of this study are the following: (1) to describe the demographical and clinical characteristics and respiratory management of these children; and (2) to identify the factors associated with mechanical ventilation (MV) and mortality. A total of 69 patients, encompassing 88 episodes, were included (55/88 cases were hypoxemic RF). The first respiratory support at PICU admission was, in decreasing order of frequency, high-flow oxygen nasal cannula (HFNC; 50/88), noninvasive ventilation (NIV; 13/88), ...
Source: Journal of Pediatric Hematology Oncology - July 18, 2015 Category: Hematology Tags: Original Articles Source Type: research

Progress in Palliative Care Benefit of Elderly Patients with Non-small Cell Lung Cancer
Lung cancer is the leading cause of death among all cancers in China. It also has the highest incidence when compared to other cancers. Almost half of all lung cancers occur over 70-year-old. Approximately 85% of all lung cancers are non-small cell lung cancer (NSCLC). The majority of patients are advanced lung cancer. Due to the unique alterations in physiology, elderly patients are at a greater risk of toxicity from chemotherapy. Palliative care as a special medical care is an important treatment for elderly patients with advanced NSCLC. Low-dose palliative radiotherapy can improve respiratory symptoms in elderly patient...
Source: Chinese Journal of Lung Cancer - July 18, 2015 Category: Cancer & Oncology Source Type: research

Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms
Abstract The purpose of this study was to analyze the molecular mechanisms of ampicillin-resistant Haemophilus influenzae isolated in Geneva, Switzerland. We investigated the association between specific patterns of amino acid substitutions in penicillin-binding protein 3 (with or without β-lactamase production) and β-lactam susceptibility. Another main focus for this study was to compare the accuracy of disk diffusion and Etest methods to detect resistance to ampicillin and amoxicillin/clavulanic acid. The antibiotic susceptibility to β-lactam antibiotics of 124 H. influenzae isolates was determined by disk ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - July 18, 2015 Category: Microbiology Source Type: research

Audiovisual biofeedback breathing guidance for lung cancer patients receiving radiotherapy: a multi-institutional phase II randomised clinical trial
This study is powered to determine the impact of AV biofeedback on breathing regularity and medical image quality. Objectives such as determining the indications and contra-indications for the use of AV biofeedback, evaluation of patient experience, radiation toxicity occurrence and severity, and clinician confidence will shed light on the design of future phase III clinical trials.Trial registrationThis trial has been registered with the Australian New Zealand Clinical Trials Registry (ANZCTR), its trial ID is ACTRN12613001177741. (Source: BMC Cancer)
Source: BMC Cancer - July 18, 2015 Category: Cancer & Oncology Authors: Sean PollockRicky O¿BrienKuldeep MakhijaFiona Hegi-JohnsonJane LudbrookAngela RezoRegina TseThomas EadeRoland Yeghiaian-AlvandiVal GebskiPaul Keall Source Type: research

Effects Acupuncture at the Yintang and the Chengjiang Acupoints on Cardiac Arrhythmias and Neurocardiogenic Syncope in Emergency First Aid
This study evaluated the effectiveness of YinTang and ChengJiang acupoints on patients with cardiac arrhythmia and neurocardiogenic syncope in emergency first aid. A 45-year-old woman underwent acupuncture. She had a previous history of a valvuloplasty for rheumatic disease and two acute myocardial infarctions, followed by four catheterizations and an angioplasty. Needling of the YinTang acupoint and stimulation of the ChengJiang acupoint through acupressure were performed for 20 minutes soon after syncope and during tachycardia, hypertension, tachypnea, and precordial pain, without any effect on peripheral oxygen saturati...
Source: Journal of Acupuncture and Meridian Studies - July 18, 2015 Category: Complementary Medicine Source Type: research

In-Office Laryngeal Laser Treatment
Abstract The advancement of lasers and optics over the last half of the twentieth century has enabled the otolaryngologist to visualize and treat many diseases heretofore treated only in the operating room. The laryngologist, specifically, can now use fiber-based lasers and thin working channel scopes to diagnose and treat many laryngologic conditions in the office. Pulsed-dye lasers and potassium titanyl phosphate lasers are utilized to treat granulomas, polyps, recurrent respiratory papillomatosis, airway stenosis, reinke’s edema, leukoplakia, and vascular lesions without the need for general anesthesia or the...
Source: Current Otorhinolaryngology Reports - July 18, 2015 Category: ENT & OMF Source Type: research

Analytical performance of the automated multianalyte point-of-care mariPOC® for the detection of respiratory viruses
The analytical performance of mariPOC® respi test (ArcDia® Laboratories, Turku, Finland) was evaluated using nucleic acid amplification techniques (NAATs) as the gold standard. The mariPOC assay allows automated detection of antigens from eight respiratory viruses: influenza A and B viruses, respiratory syncytial virus, adenovirus, human metapneumovirus and parainfluenza viruses 1–3. Positive results from samples with high viral load are available in 20 minutes. Nasopharyngeal aspirates (n= 192) from patients with acute respiratory infection and from previously positive samples were analyzed by mariPOC and NAATs [Simpl...
Source: Diagnostic Microbiology and Infectious Disease - July 18, 2015 Category: Microbiology Authors: Sara Sanbonmatsu-Gámez, Mercedes Pérez-Ruiz, Ana Lara-Oya, Irene Pedrosa-Corral, Cristina Riazzo-Damas, José María Navarro-Marí Source Type: research

Use of proteomics in the study of microbial diseases of small ruminants
Publication date: Available online 17 July 2015 Source:Veterinary Microbiology Author(s): A.I. Katsafadou, G.T. Tsangaris, C. Billinis, G.C. Fthenakis Objective of the paper is to review potential applications of proteomics methodologies in the study of microbial diseases of small ruminants. Proteomics has been employed for the elucidation of pathogenesis of various diseases, i.e., in the study of determinants of microbial agents and the study of host-pathogen interactions, as well as in improved disease diagnosis by the identification of biomarkers. Extensive uses of proteomics in sheep and goat diseases have been a...
Source: Veterinary Microbiology - July 18, 2015 Category: Veterinary Research Source Type: research

Vaccination schedules in small ruminant farms
Publication date: Available online 17 July 2015 Source:Veterinary Microbiology Author(s): D. Lacasta, L.M. Ferrer, J.J. Ramos, J.M. González, A. Ortín, G.C. Fthenakis Development and implementation of health management plans is the cornerstone of profitable farms; prevention of microbial diseases by means of vaccination is an integral part of such a plan. In every production type and management system in small ruminants, microbial diseases have a major significance, hence their proper control must be based in good health management practices, including use of effective and safe vaccines. Development of various ty...
Source: Veterinary Microbiology - July 18, 2015 Category: Veterinary Research Source Type: research

Animal models of Middle East Respiratory Syndrome coronavirus infection
This article forms part of a symposium in Antiviral Research on “From SARS to MERS: research on highly pathogenic human coronaviruses.” (Source: Antiviral Therapy)
Source: Antiviral Therapy - July 18, 2015 Category: Virology Source Type: research

Noninvasive Ventilation in Pediatric Acute Respiratory Illness
This article describes the properties of different modalities of NIV and reviews the medical literature regarding use of NIV in pediatric patients with acute respiratory illness. (Source: Clinical Pediatric Emergency Medicine)
Source: Clinical Pediatric Emergency Medicine - July 18, 2015 Category: Emergency Medicine Authors: Robyn Wing, Carrie C. Armsby Source Type: research

Modeling of pharyngeal pressure during adult nasal high flow therapy
In this study, airflow in the nasal airway during NHF-assisted breathing is simulated and nasopharyngeal airway pressure numerically computed, to determine whether the relationship between NHF and pressure can be described by a simple equation. Two geometric models are used for analysis. In the first, 3D airway geometry is reconstructed from computed tomography images of an adult nasal airway. For the second, a simplified geometric model is derived that has the same cross-sectional area as the complex model, but is more readily amenable to analysis. Peak airway pressure is correlated as a function of nasal valve area, nost...
Source: Respiratory Physiology and Neurobiology - July 18, 2015 Category: Respiratory Medicine Source Type: research

Altered lung function at mid-adulthood in mice following neonatal exposure to hyperoxia.
Publication date: Available online 18 July 2015 Source:Respiratory Physiology & Neurobiology Author(s): Foula Sozo, Jay C. Horvat, Ama-Tawiah Essilfie, Megan O'Reilly, Philip M. Hansbro, Richard Harding Infants born very preterm are usually exposed to high oxygen concentrations but this may impair lung function in survivors in later life. However, the precise changes involved are poorly understood. We determined how neonatal hyperoxia alters lung function at mid-adulthood in mice. Neonatal C57BL/6J mice inhaled 65% oxygen (HE group) from birth for 7 days. They then breathed room air until 11 months of age (...
Source: Respiratory Physiology and Neurobiology - July 18, 2015 Category: Respiratory Medicine Source Type: research

Varicocele negatively affects sperm mitochondrial respiration
To evaluate the effect of varicocele on oxidative stress, sperm mitochondrial respiratory efficiency, sperm morphology and semen parameters. (Source: Urology)
Source: Urology - July 18, 2015 Category: Urology & Nephrology Authors: Alessandra Ferramosca, Denise Albani, Lamberto Coppola, Vincenzo Zara Source Type: research

New Paradigms in Sepsis: From Prevention to Protection of Failing Microcirculation.
This article is protected by copyright. All rights reserved. PMID: 26190521 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - July 18, 2015 Category: Hematology Authors: Hawiger J, Veach RA, Zienkiewicz J Tags: J Thromb Haemost Source Type: research

Innate and adaptive cellular phenotypes contributing to pulmonary disease in mice after respiratory syncytial virus immunization and infection.
Abstract Respiratory syncytial virus (RSV) is the major leading cause of infantile viral bronchiolitis. However, cellular phenotypes contributing to the RSV protection and vaccine-enhanced disease remain largely unknown. Upon RSV challenge, we analyzed phenotypes and cellularity in the lung of mice that were naïve, immunized with formalin inactivated RSV (FI-RSV), or re-infected with RSV. In comparison with naïve and live RSV re-infected mice, the high levels of eosinophils, neutrophils, plasmacytoid and CD11b(+) dendritic cells, and IL-4(+) CD4(+) T cells were found to be contributing to pulmonary inflammation i...
Source: Virology - July 18, 2015 Category: Virology Authors: Lee YT, Kim KH, Hwang HS, Lee Y, Kwon YM, Ko EJ, Jung YJ, Lee YN, Kim MC, Kang SM Tags: Virology Source Type: research

Health care costs and work absenteeism in smokers: study in an urban community.
CONCLUSION: More investment in programs for the prevention and treatment of smoking, as a health policy priority, could help to reduce the health and social costs of smoking. PMID: 26198012 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)
Source: Archivos de Bronconeumologia - July 18, 2015 Category: Respiratory Medicine Authors: Suárez-Bonel MP, Villaverde-Royo MV, Nerín I, Sanz-Andrés C, Mezquida-Arno J, Córdoba-García R Tags: Arch Bronconeumol Source Type: research

Conceptual Model for Assessing Criteria Air Pollutants in a Multipollutant Context :A Modified Adverse Outcome Pathway Approach.
Abstract Air pollution consists of a complex mixture of particulate and gaseous components. Individual criteria and other hazardous air pollutants have been linked to adverse respiratory and cardiovascular health outcomes. However, assessing risk of air pollutant mixtures is difficult since components are present in different combinations and concentrations in ambient air. Recent mechanistic studies have limited utility because of the inability to link measured changes to adverse outcomes that are relevant to risk assessment. New approaches are needed to address this challenge. The purpose of this manuscript is to ...
Source: Toxicology - July 18, 2015 Category: Toxicology Authors: Buckley B, Farraj A Tags: Toxicology Source Type: research

Etomidate Anesthesia during ERCP Caused More Stable Haemodynamic Responses Compared with Propofol: A Randomized Clinical Trial.
Conclusions: Etomidate anesthesia during ERCP caused more stable haemodynamic responses compared with propofol. PMID: 26180512 [PubMed - as supplied by publisher] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 17, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Depressed Systemic Arterial Compliance is Associated with the Severity of Heart Failure Symptoms in Moderate-to-Severe Aortic Stenosis: a Cross-Sectional Retrospective Study.
CONCLUSIONS: Depressed SAC may enhance exercise intolerance irrespective of stenosis severity or left ventricular systolic function in moderate-to-severe AS. This finding supports the importance of non-valvular factors for symptomatic status in AS. PMID: 26180511 [PubMed - in process] (Source: International Journal of Medical Sciences)
Source: International Journal of Medical Sciences - July 17, 2015 Category: Biomedical Science Tags: Int J Med Sci Source Type: research

Cadmium toxicity induces ER stress and apoptosis via impairing energy homoeostasis in cardiomyocytes.
Abstract Cadmium, a highly toxic environmental pollutant, is reported to induce toxicity and apoptosis in multiple organs and cells, all possibly contributing to apoptosis in certain pathophysiologic situations. Previous studies have described that cadmium toxicity induces biochemical and physiological changes in the heart and finally leads to cardiac dysfunctions, such as decreasing contractile tension, rate of tension development, heart rate, coronary flow rate and atrioventricular node conductivity. Although many progresses have been made, the mechanism responsible for cadmium-induced cellular alternations and c...
Source: Bioscience Reports - July 17, 2015 Category: Biomedical Science Authors: Chen CY, Zhang SL, Liu ZY, Tian Y, Sun Q Tags: Biosci Rep Source Type: research

Incidence and outcome of lung involvement in IgG4‐related autoimmune pancreatitis
We evaluated the incidence and outcome of lung involvement in 35 patients with autoimmune pancreatitis (AIP). Our results indicate that lung involvement is commonly observed in AIP (40%). In addition, corticosteroid treatment improved the lung lesions and appeared to reduce the probability of relapse compared with pancreatic lesions (0% vs 36%). This is the first report to assess the long‐term outcome of lung involvement in AIP (52 ± 33 months). (Source: Respirology)
Source: Respirology - July 17, 2015 Category: Respiratory Medicine Authors: Takaaki Ogoshi, Takashi Kido, Kazuhiro Yatera, Keishi Oda, Chinatsu Nishida, Kei Yamasaki, Takeshi Orihashi, Yukiko Kawanami, Hiroshi Ishimoto, Masashi Taguchi, Masaru Harada, Hiroshi Mukae Tags: Scientific Letter Source Type: research

Risk factors for major complications in surgery for hypervascular spinal tumors: an analysis of 120 cases with adjuvant preoperative embolization
Conclusion Major complications in surgery for hypervascular spinal tumors after embolization are prevalent. Risk factors identified in this study are useful prognostic indicators when considering surgical treatment combined with embolization. (Source: European Spine Journal)
Source: European Spine Journal - July 17, 2015 Category: Orthopaedics Source Type: research

Respir Care; +130 new citations
130 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Respir Care These pubmed results were generated on 2015/07/17PubMed comprises more than 24 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Respiratory Care)
Source: Respiratory Care - July 17, 2015 Category: Respiratory Medicine Tags: Report Source Type: research