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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Interactive Effects of Body Position and Perceived Exertion During Spinning Exercises
This study examined the effects of 3 body positions and 4 levels of perceived exertion (RPE) on cardiorespiratory response and vastus lateralis normalized electromyographical activity (NrmsEMGVL). Eleven participants (24.4 ± 6.3 years) with 3.2 ± 2.2 years of Spinning experience completed twelve 3-minute randomly assigned Spinning conditions across 4 separate testing days after an 8-hour fast. Conditions were determined by body position (seated, running, and standing climb [SC]) and RPE (low, low-medium, medium-high, and high). Cardiorespiratory data and NrmsEMGVL were recorded continuously during each Spinning condition...
Source: Journal of Strength and Conditioning Research - February 26, 2015 Category: Sports Medicine Tags: Original Research Source Type: research

Influence of a Custom-Made Maxillary Mouthguard on Gas Exchange Parameters During Incremental Exercise in Amateur Road Cyclists
Abstract: Piero, M, Simone, U, Jonathan, M, Maria, S, Giulio, G, Francesco, T, Gabriella, C, Laura, A, Eva, B, Gianni, M, Francesco, C, and Giovanni, G. Influence of a custom-made maxillary mouthguard on gas exchange parameters during incremental exercise in amateur road cyclists. J Strength Cond Res 29(3): 672–677, 2015—Mouthguards are frequently used for protection purposes, particularly by athletes competing in contact sports. However, there is increasing evidence supporting their use for improving performance. Studies have focused their use in athletes who do not traditionally use mouthguards and who may be looking...
Source: Journal of Strength and Conditioning Research - February 26, 2015 Category: Sports Medicine Tags: Original Research Source Type: research

T cell subsets in human airways prior to and following endobronchial administration of endotoxin
ConclusionsA unique distribution of T cells with little day‐to‐day variation was found in human airways. An increase in Tregs after endobronchial LPS suggests a role for Tregs during early stages of pulmonary inflammation. (Source: Respirology)
Source: Respirology - February 26, 2015 Category: Respiratory Medicine Authors: Andreas Ronit, Ronni R. Plovsing, Julie C. Gaardbo, Ronan M.G. Berg, Hans J. Hartling, Lars Konge, Martin Iversen, Henrik Ullum, Kirsten Møller, Susanne Dam Nielsen Tags: Original Article Source Type: research

Optic Neuropathy Secondary to Eosinophilic Angiocentric Fibrosis
We report a 45-year-old man with progressive unilateral visual loss secondary to a retroorbital soft tissue mass with histological features consistent with EAF. The patient experienced marked improvement in vision after endoscopic optic nerve decompression through sphenoethmoidectomy. (Source: Journal of Neuro-Ophthalmology)
Source: Journal of Neuro-Ophthalmology - February 26, 2015 Category: Opthalmology Tags: Photo Essay Source Type: research

18F-FDG PET/CT lung ‘focalities’ without coregistered CT findings: an interpretative clinical dilemma
Conclusion: In the absence of morphological abnormality, focal pulmonary 18F-FDG activity is very rare (1.5 cases/1000 PET scans) but potentially very ‘dangerous’. Artefact identification during acquisition can lead to late respiratory gated images for more confident interpretation, avoiding erroneous reports or further imaging procedures. (Source: Nuclear Medicine Communications)
Source: Nuclear Medicine Communications - February 26, 2015 Category: Nuclear Medicine Tags: Original Articles Source Type: research

Sodium balance, not fluid balance, is associated with respiratory dysfunction in mechanically ventilated patients: a prospective, multicentre study.
CONCLUSIONS: The cumulative positive sodium balance, not the cumulative positive fluid balance, is associated with respiratory dysfunction and an increased length of MV. PMID: 25702758 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 26, 2015 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Primary fluid bolus therapy for infectionassociated hypotension in the emergency department.
CONCLUSION: Among ED patients admitted to an Australian teaching hospital with infection, hypotension was uncommon. FBT for hypotension was limited in volumes given and failed to achieve a sustained SBP of > 100mmHg in 40% of cases. In contrast, noradrenaline therapy corrected hypotension in all patients who received it. PMID: 25702756 [PubMed - in process] (Source: Critical Care and Resuscitation)
Source: Critical Care and Resuscitation - February 26, 2015 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Sleep breathing disorders and nocturnal respiratory pattern in patients with glycogenosis type II.
Authors: Fiorentino G, Annunziata A, Politano L Abstract Patients affected by glycogenosis type II frequently present sleep disordered breathing. The presence of symptoms suggestive of sleep breathing disorders was investigated, by a questionnaire, in 10 patients, affected by adult or juvenile forms of glycogenosis type II. Diurnal respiratory function, diaphragm weakness and nocturnal respiratory pattern were evaluated at the enrolment. In patients presenting sleep disordered breathing, the same parameters were re-evaluated after treatment with assisted non invasive ventilation. Out of 10 patients, 5 presented sym...
Source: Acta Myologica - February 26, 2015 Category: Neurology Tags: Acta Myol Source Type: research

Pleural subxyphoid drain confers better pulmonary function and clinical outcomes in chronic obstructive pulmonary disease after off-pump coronary artery bypass grafting: a randomized controlled trial
Conclusion: Subxyphoid pleural drainage in severe Chronic obstructive pulmonary disease patients determined better preservation and recovery of pulmonary capacity and volumes with lower pulmonary shunt fraction and better clinical outcomes on early postoperative off-pump coronary artery bypass grafting. Objetivo: Avaliar a função pulmonar e os resultados clínicos em pacientes com doença pulmonar obstrutiva crônica grave submetidos à cirurgia de revascularização do miocárdio sem circulação extracorpórea, com enxerto da artéria torácica interna esquerda, comparando a inserção do dreno pleural intercostal vers...
Source: Revista Brasileira de Cirurgia Cardiovascular - February 26, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research

Different duration strategies of perioperative antibiotic prophylaxis in adult patients undergoing cardiac surgery: an observational study
Conclusions: Reducing the duration of PAB from 56 h to 32 h in adult cardiac surgery patients was not associated with an increase of nosocomial infection rate, but contributes to reduce antibiotic resistance and health care costs. (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - February 26, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Khaled HamoudaMehmet OezkurBhanu SinhaJohannes HainHannah MenkelMarcus LeistnerRainer LeyhChristoph Schimmer Source Type: research

A comparative analysis of 3 sedation guidelines for patients undergoing subarachnoid anesthesia. Randomized, single blind clinical trial
Conclusions The three sedation guidelines presented were effectively used in subarachnoid anesthesia; the results were more favorable with the use of midazolam+fentanyl or midazolam+ketamine. p-2011-1682 Colciencias. Registro # NCT0213664 (clinicaltrials.gov,prospectivo). (Source: Colombian Journal of Anesthesiology)
Source: Colombian Journal of Anesthesiology - February 26, 2015 Category: Anesthesiology Source Type: research

Clinical characteristics of hospital-onset Pneumocystis pneumonia and genotypes of Pneumocystis jirovecii in a single tertiary centre in Korea
Conclusions: PCP can be one of the causes of nosocomial pneumonia, although the mode of acquisition and transmission of P. jirovecii remains uncertain. mtLSU genotype 1 is the predominant P. jirovecii strain in Korea. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 26, 2015 Category: Infectious Diseases Authors: Tark KimSang-Oh LeeHyo-Lim HongJu LeeSung-Han KimSang-Ho ChoiMi-Na KimYang KimJun WooHeungsup Sung Source Type: research

Mannan adjuvants intranasally administered inactivated influenza virus in mice rendering low doses inductive of strong serum IgG and IgA in the lung
Conclusions: Mixing 100 μg of mannan with 1 μg of inactivated H1N1 adjuvanted the vaccine in mice, such that IN immunisation induced higher serum IgG and respiratory tract IgA than immunisation with virus alone. The serum from mice thus immunised inhibited H1N1-mediated RBC agglutination strongly in vitro. If mannan similarly adjuvants low doses of influenza vaccine in humans, it could potentially be used for vaccine ‘dose-sparing’ in the event that a vaccine shortage arises from an epidemic involving a highly virulent human-to-human transmissable influenza strain. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 26, 2015 Category: Infectious Diseases Authors: Owen ProudfootSandra EsparonChoon-Kit TangKaren LaurieIan BarrGeoffrey Pietersz Source Type: research

Predicting mortality following hip fracture: an analysis of comorbidities and complications
Conclusions This study highlights specific patient comorbidities and medical complications that could be used to guide clinical assessment, management and targeted interventions that improve outcomes in this patient group. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - February 26, 2015 Category: Journals (General) Source Type: research

Evaluation of electrolyte imbalance among tuberculosis patients receiving treatments in Southwestern Nigeria
Conclusion Hyponatraemia, hyperkalaemia, and hypochloremia characterized some of the electrolyte imbalance among TB patients receiving treatments. The raised level of bicarbonate may be attributed to overcorrection of respiratory acidosis often found in patients with tuberculosis. Monitoring electrolytes is therefore an important component of TB management. (Source: Alexandria Journal of Medicine)
Source: Alexandria Journal of Medicine - February 26, 2015 Category: Journals (General) Source Type: research

Neural respiratory drive and symptoms that limit exercise in chronic obstructive pulmonary disease
Publication date: 26 February 2015 Source:The Lancet, Volume 385, Supplement 1 Author(s): Caroline Jolley , Yuanming Luo , Joerg Steier , Karl Sylvester , William Man , Gerrard Rafferty , Michael Polkey , John Moxham Background Exercise capacity in chronic obstructive pulmonary disease (COPD) is limited by both breathlessness and leg muscle fatigue. Neural respiratory drive, measured as diaphragm electromyogram (EMGdi) activity expressed as a proportion of maximum (EMGdi%max), quantifies the mechanical load on the respiratory muscles and relates closely to breathlessness. We tested the hypothesis that end-exercise EMGdi%...
Source: The Lancet - February 26, 2015 Category: Journals (General) Source Type: research

Respiratory cycle-dependent left atrial tachycardia in a former Tour de France cyclist
(Source: Europace)
Source: Europace - February 26, 2015 Category: Cardiology Authors: Mussigbrodt, A., Hindricks, G., Bollmann, A. Tags: CASE EXPRESS REPORTS Source Type: research

Effects of different ventilation strategies on exhaled nitric oxide in geriatric abdominal surgery
Exhaled nitric oxide (eNO) has been suggested to be a marker of small airway injury. We investigated the effects of different ventilation strategies on eNO. Sixty-nine patients who received elective open abdominal surgery under general anesthesia with more than 2 h of surgery duration were randomly divided into three groups: high tidal volume of 10–12 ml kg −1 predicted body weight (PBW) with zero end-expiratory pressure (ZEEP) (high V T + ZEEP group); low tidal volume of 6–8 ml kg −1 PBW with 8 cm H 2 O positive end-expiratory pressure (PEEP) (low V T + PEEP group); and low tidal volume of 6–8...
Source: Journal of Breath Research - February 26, 2015 Category: Respiratory Medicine Authors: Yinghua Cui, Xin Pi, Changsong Wang, Shujuan Liu, Yulei Gong, Yang Wang, Fan Zhang, Jinghui Shi, Ziwei Lin, Xin Zhang and Enyou Li Source Type: research

Effect of COPD on cognitive functions in patients with heart failure
Publication date: Available online 25 February 2015 Source:Heart & Lung: The Journal of Acute and Critical Care Author(s): Serdar Kalemci , Ibrahim Altun , Kadriye Memiç Sancar , Murat Biteker (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - February 26, 2015 Category: Respiratory Medicine Source Type: research

Perspectives from mechanical circulatory support coordinators on the pre-implantation decision process for destination therapy left ventricular assist devices
Conclusions MCS coordinators endorsed a shared decision-making process that starts early, uses non-biased educational materials, and involves a multidisciplinary team sensitive to the tension between conveying enough detail about the therapy yet not overwhelming patients. (Source: Heart and Lung: The Journal of Acute and Critical Care)
Source: Heart and Lung: The Journal of Acute and Critical Care - February 26, 2015 Category: Respiratory Medicine Source Type: research

Diagnostic yield of sputum microbiological analysis in the diagnosis of pulmonary tuberculosis in a period of 10 years
Conclusions This study showed an incremental yield with more than one sputum sample. However, overall sensitivity remained low, suggesting a need for new diagnostic strategies and novel and better diagnostic tools. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - February 26, 2015 Category: Respiratory Medicine Source Type: research

Long-term impact of pre-operative physical rehabilitation protocol on the 6-min walk test of patients with adolescent idiopathic scoliosis: A randomized clinical trial
Conclusions Post-surgical recovery, evaluated by 6MWT, was significantly better in patients who underwent a 4-month pre-operative physical rehabilitation protocol. (Source: Revista Portuguesa de Pneumologia)
Source: Revista Portuguesa de Pneumologia - February 26, 2015 Category: Respiratory Medicine Source Type: research

Comparison of Rhabdomyolysis Markers in Patients Undergoing Bariatric Surgery with Propofol and Inhalation-based Anesthesia
Conclusions This small-size pilot study may suggest that propofol-based anesthesia is not related to increased incidence of rhabdomyolysis in morbidly obese patients undergoing short, uncomplicated bariatric surgery. (Source: Obesity Surgery)
Source: Obesity Surgery - February 26, 2015 Category: Surgery Source Type: research

Towards a more complete understanding of the association between a hepatitis C sustained viral response and cause‐specific outcomes
CONCLUSIONS: The conclusions are three‐fold: 1) Overall, SVR is associated with reduced hazard for a range of hepatic and non‐hepatic events. 2) An association between SVR and behavioural events is consistent with SVR patients leading healthier lives, 3) The short‐term value of SVR is greatest for those with non‐mild disease. This article is protected by copyright. All rights reserved. (Source: Hepatology)
Source: Hepatology - February 26, 2015 Category: Internal Medicine Authors: Hamish A Innes, Scott A McDonald, John F Dillon, Sam Allen, Peter C Hayes, David Goldberg, Peter R Mills, Stephen T Barclay, David Wilks, Heather Valerio, Ray Fox, Diptendu Bhattacharyya, Nicholas Kennedy, Judith Morris, Andrew Fraser, Adrian J Stanley, P Tags: Viral Hepatitis Source Type: research

Nebulized antibiotics. An adequate option for treating ventilator-associated respiratory infection?
Publication date: Available online 25 February 2015 Source:Medicina Intensiva (English Edition) Author(s): A. Rodríguez , F. Barcenilla (Source: Medicina Intensiva)
Source: Medicina Intensiva - February 26, 2015 Category: Intensive Care Source Type: research

Does chronic oxygen dependency in preterm infants with bronchopulmonary dysplasia at NICU discharge predict respiratory outcomes at 3 years of age?
Does chronic oxygen dependency in preterm infants with bronchopulmonary dysplasia at NICU discharge predict respiratory outcomes at 3 years of age? Journal of Perinatology advance online publication, February 26 2015. doi:10.1038/jp.2015.7 Authors: A Lodha, K Ediger, Y Rabi, S Lodha, S Tang, A Bhandari, R Sauve & V Bhandari (Source: Journal of Perinatology)
Source: Journal of Perinatology - February 26, 2015 Category: Perinatology & Neonatology Authors: A LodhaK EdigerY RabiS LodhaS TangA BhandariR SauveV Bhandari Source Type: research

Respiratory Sinus Arrhythmia Moderates the Relation between Parent-Adolescent Relationship Quality and Adolescents' Social Adjustment.
Abstract This 2-wave longitudinal study aimed (1) to investigate whether high resting RSA predicted adolescents' lower externalizing behavior and higher empathic concern, and (2) to address the potential moderating role of resting RSA in the association between parent-adolescent relationship quality and adolescents' externalizing behavior and empathic concern. In a sample of 379 adolescents (212 boys, 167 girls), resting RSA was assessed during a laboratory session, and adolescents reported on parental support, negative interaction with parents, empathic concern and externalizing behavior during a home visit. We fo...
Source: Journal of Abnormal Child Psychology - February 26, 2015 Category: Psychiatry & Psychology Authors: Van der Graaff J, Meeus W, de Wied M, van Boxtel A, van Lier P, Branje S Tags: J Abnorm Child Psychol Source Type: research

Molecular characterization of H9N2 influenza virus isolated from mink and its pathogenesis in mink
Publication date: 23 March 2015 Source:Veterinary Microbiology, Volume 176, Issues 1–2 Author(s): Li Peng , Chen Chen , Han Kai-yi , Zhang Feng-xia , Zhu Yan-li , Ling Zong-shuai , Zhang Xing-xiao , Jiang Shi-jin , Xie Zhi-jing In mid-August 2013, two H9N2 influenza viruses, named A/mink/Shandong/F6/2013 (Mk/SD/F6/13) and A/mink/Shandong/F10/2013 (Mk/SD/F10/13), were isolated from lung samples of 2 of 45 farmed mink exhibiting respiratory signs in mideastern Shandong province, China. The seroprevalence of antibodies to H9N2 in mink was 20% (53/265). Based on sequence analysis, the eight nucleotide sequences showed 99.7...
Source: Veterinary Microbiology - February 26, 2015 Category: Veterinary Research Source Type: research

Rhinovirus is an important pathogen in upper and lower respiratory tract infections in Mexican children
Conclusions: Both RV-A and RV-C species were frequently found in hospitalized as well as in outpatient children. This study underlines the high prevalence and genetic diversity of RV strains in Mexico and the potential severity of disease associated with RV-A and RV-C infections. (Source: Virology Journal)
Source: Virology Journal - February 26, 2015 Category: Virology Authors: Fernando AponteBlanca TaboadaMarco EspinozaMaría Arias-OrtizJesús Monge-MartínezRubén Rodríguez-VázquezFidel Díaz-HernándezFernando Zárate-VidalRosa Wong-ChewVerónica Firo-ReyesCarlos del Río-AlmendárezJesús Gaitán-MezaAlberto Villaseñor-Si Source Type: research

Molecular epidemiology and molecular characterisation of respiratory syncytial viruses at a tertiary care university hospital in Catalonia (Spain) during the 2013–2014 season
Human respiratory syncytial virus (HRSV) is the most common respiratory pathogen and the main cause of lower respiratory tract infections (LRTI) among infants and young children. Primary infection usually affects infants under two years of age, and reinfections are common throughout life. HRSV is also recognised as a significant respiratory pathogen among immunosuppressed and elderly patients. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - February 26, 2015 Category: Virology Authors: Laura Gimferrer, Magda Campins, Maria Gema Codina, Maria del Carmen Martin, Francisco Fuentes, Juliana Esperalba, Andreu Bruguera, Luz María Vilca, Lluis Armadans, Tomàs Pumarola, Andrés Antón Source Type: research

HIV-gp120 and physical dependence to buprenorphine
Buprenorphine is a semi-synthetic derivative of thebaine. It has a molecular weight of 467 and its structure is typically opioid with the inclusion of a C-7 side-chain containing a t-butyl group. Comparison of the antinociceptive effects of methadone and buprenorphine shows that 3mg/kg for methadone is the effective analgesic dose, and 0.3mg/kg for buprenorphine in rats using the hot-plate test (Bulka et al., 2004). Respiratory depression caused by opioids can be potentially life-threatening but is much less of a problem with buprenorphine than with many other opioids including morphine, hydromorphone, methadone, oxycodone...
Source: Drug and Alcohol Dependence - February 26, 2015 Category: Addiction Authors: J. Palma, M.E. Abood, K. Benamar Tags: Short communication Source Type: research

IL‐33 receptor (ST2) signaling is important for regulation of Th2‐mediated airway inflammation in a murine model of acute respiratory syncytial virus infection
This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - February 26, 2015 Category: Allergy & Immunology Authors: Sheng Zeng, Jianqi Wu, Jing Liu, Feifei Qi, Beixing Liu Tags: Regular Article Source Type: research

Capabilities of a mobile extracorporeal membrane oxygenation service for severe respiratory failure delivered by intensive care specialists
Summary We conducted a single‐centre observational study of retrievals for severe respiratory failure over 12 months. Our intensivist‐delivered retrieval service has mobile extracorporeal membrane oxygenation capabilities. Sixty patients were analysed: 34 (57%) were female and the mean (SD) age was 44.1 (13.6) years. The mean (SD) PaO2/FIO2 ratio at referral was 10.2 (4.1) kPa and median (IQR [range]) Murray score was 3.25 (3.0–3.5 [1.5–4.0]). Forty‐eight patients (80%) required veno‐venous extracorporeal membrane oxygenation at the referring centre. There were no cannulation or extracorporeal membrane oxyge...
Source: Anaesthesia - February 26, 2015 Category: Anesthesiology Authors: P. B. Sherren, S. J. Shepherd, G. W. Glover, C. I. S. Meadows, C. Langrish, N. Ioannou, D. Wyncoll, K. Daly, N. Gooby, N. Agnew, N. A. Barrett Tags: Original Article Source Type: research

Enterovirus D68
This article examines recent trends in EV-D68 infections, reviewing past outbreaks and the 2014 outbreak, and describes the increasing cases of acute flaccid myelitis and their possible connection with EV-D68. (Source: Emergency Medicine Clinics of North America)
Source: Emergency Medicine Clinics of North America - February 26, 2015 Category: Emergency Medicine Authors: Feras Khan Source Type: research

Further Consideration in Evaluation of Right Ventricular Infarction
We read with great pleasure the interesting report by Aiman et al.1 The proposed hypothesis of vasospasm of isolated right sided coronary arteries is appealing and well possible however other relevant considerations should be entertained especially in the absence of objective evidence of vasospasm during coronary angiography. Since the patient was unresponsive, hypotensive and acidotic, concomitant significant hypoxia is presumably highly likely. Patients with hypoxic respiratory failure or even drug overdose can manifest as transient right ventricular dysfunction and also frequently with biventricular dysfunction. (Source...
Source: The American Journal of Emergency Medicine - February 26, 2015 Category: Emergency Medicine Authors: Lovely Chhabra, Vinod K. Chaubey Tags: Correspondence Source Type: research

Polyhexamethylene guanidine phosphate aerosol particles induce pulmonary inflammatory and fibrotic responses.
This study aimed to elucidate the toxicological relationship between PHMG-phosphate aerosol particles and pulmonary fibrosis. An in vivo nose-only exposure system and an in vitro air-liquid interface (ALI) co-culture model were applied to confirm whether PHMG-phosphate induces inflammatory and fibrotic responses in the respiratory tract. Seven-week-old male Sprague-Dawley rats were exposed to PHMG-phosphate aerosol particles for 3 weeks and recovered for 3 weeks in a nose-only exposure chamber. In addition, three human lung cells (Calu-3, differentiated THP-1 and HMC-1 cells) were cultured at ALI condition for 12 days a...
Source: Archives of Toxicology - February 26, 2015 Category: Toxicology Authors: Kim HR, Lee K, Park CW, Song JA, Shin DY, Park YJ, Chung KH Tags: Arch Toxicol Source Type: research

What’s trending in the infection prevention and control literature? From HIS 2012 to HIS 2014, and beyond
Publication date: Available online 21 February 2015 Source:Journal of Hospital Infection Author(s): J.A. Otter This is an informal review of some of the trends in the infection prevention and control literature since the last Healthcare Infection Society (HIS) conference in late 2012. Google Trends was used to investigate how the volume of interest in various infection control topics had changed over time. Ebola trumped all the others in Google searches, reflecting a surge of publications in the literature. Aside from Ebola, other trends in the infection prevention and control literature covered in this article include M...
Source: Journal of Hospital Infection - February 26, 2015 Category: Infectious Diseases Source Type: research

Assessing the risk of in-flight hypoxia: chronic lung disease of prematurity and children with neuromuscular disorders
Most children will experience a small, clinically insignificant drop in oxygen saturation during air travel due to the effects of altitude. Clinically significant hypoxia may occur in individuals with an underlying cardio-respiratory condition, in particular young infants born prematurely or with chronic lung disease of prematurity and in children with neuromuscular disorders. To date there is very little in-flight data available in these clinical populations to allow the development of evidence based guidelines for pre-flight assessment of the risk of hypoxia in-flight. (Source: Paediatrics and Child Health)
Source: Paediatrics and Child Health - February 26, 2015 Category: Pediatrics Authors: Graham L. Hall, Adelaide Withers Tags: Personal practice Source Type: research

Do all patients with idiopathic pulmonary fibrosis warrant a trial of therapeutic intervention? A pro‐con perspective
Abstract Idiopathic pulmonary fibrosis (IPF) is an incurable condition that is characterized by progressive pulmonary fibrosis, architectural distortion of the lung and loss of gas exchange units. Until recently, there was no effective treatment for this condition. However, there were two landmark trials published earlier this year, which have changed the management of this condition. Pirfenidone (Assessment of Pirfenidone to Confirm Efficacy and Safety in Idiopathic Pulmonary Fibrosis trial) and nintedanib (Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis‐1 and ‐2 trials) have both demonstrated posit...
Source: Respirology - February 26, 2015 Category: Respiratory Medicine Authors: Yuben Moodley, Tamera Corte, Luca Richeldi, Talmadge E. King Tags: Invited Review Source Type: research

Delayed access to treatments for rare diseases: Who's to blame?
Abstract The development and commercialization of drugs for rare diseases, termed ‘orphan drugs’, has historically been economically unattractive. However, because of the introduction of legislation that provides financial and regulatory incentives for the development of orphan drugs, new developments are making their way through the regulatory approval processes. Unfortunately, delays in availability of new drugs for treating rare disease continue to persist. This paper reviews the approach of several regulatory jurisdictions to orphan drugs in an effort to determine their relative effectiveness in providing patient a...
Source: Respirology - February 26, 2015 Category: Respiratory Medicine Authors: Karen Feltmate, Peter M. Janiszewski, Sheena Gingerich, Michael Cloutier Tags: Invited Review Series: Challenges in Drug Development for Chronic Lung Diseases Source Type: research

Vascular Repair by Tissue-resident Endothelial Progenitor Cells in Endotoxin-induced Lung Injury.
Abstract Vascular disruption is one of the pathological hallmarks in acute respiratory distress syndrome (ARDS). Bone marrow (BM)-derived circulating endothelial progenitor cells (EPCs) and lung tissue-resident EPCs have been considered to play a pivotal role in pulmonary vascular repair; however, which population is predominant in local pulmonary vasculogenesis remains to be clarified. We therefore examined the origin of EPCs participating in the regenerative process of pulmonary vascular endothelial cells (PVECs) in experimental ARDS. Lung samples from mice administered LPS intratracheally were investigated for c...
Source: American Journal of Respiratory Cell and Molecular Biology - February 26, 2015 Category: Molecular Biology Authors: Kawasaki T, Nishiwaki T, Sekine A, Nishimura R, Suda R, Urushibara T, Suzuki T, Takayanagi S, Terada J, Sakao S, Tatsumi K Tags: Am J Respir Cell Mol Biol Source Type: research

[Acute viral bronchiolitis: A national study in pediatric emergency departments.]
CONCLUSION: The clinical criteria of the 2000 French guidelines influence hospitalization for acute viral bronchiolitis in pediatric emergency departments. However, other criteria are cited in about one-third of the patients. PMID: 25727472 [PubMed - as supplied by publisher] (Source: Archives de Pediatrie)
Source: Archives de Pediatrie - February 26, 2015 Category: Pediatrics Authors: Pailhous S, Bresson V, Loundou A, Gras-Le-Guen C, Marguet C, Chabrol B, Dubus JC Tags: Arch Pediatr Source Type: research

Characterizing the mechanism of thiazolidinedione-induced hepatotoxicity: an in vitro model in mitochondria.
CONCLUSION:: All investigated TZDs show a certain degree of mitochondrial toxicity, with troglitazone exhibiting the highest potency. The underlying mechanism of TZD-induced hepatotoxicity may be associated with alterations in mitochondrial respiratory function disorders, oxidative stress, and changes in membrane permeability. These parameters may be used early in drug development to further optimize risk: benefit profiles. PMID: 25727309 [PubMed - as supplied by publisher] (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - February 26, 2015 Category: Toxicology Authors: Hu D, Wu CQ, Li ZJ, Liu Y, Fan X, Wang QJ, Ding RG Tags: Toxicol Appl Pharmacol Source Type: research

Carbon monoxide signaling
Levitt DG, Levitt MD (Source: International Journal of COPD)
Source: International Journal of COPD - February 25, 2015 Category: Respiratory Medicine Source Type: research

Results of a Pilot Study using Self‐Collected Mid‐Turbinate Nasal Swabs for Detection of Influenza Virus Infection among Pregnant Women
This article is protected by copyright. All rights reserved. (Source: Influenza and Other Respiratory Viruses)
Source: Influenza and Other Respiratory Viruses - February 25, 2015 Category: Virology Authors: Mark G. Thompson, Jeannette R. Ferber, Roxana Odouli, Donna David, Pat Shifflett, Jennifer K. Meece, Allison L. Naleway, Sam Bozeman, Sarah M. Spencer, Alicia M. Fry, De‐Kun Li Tags: Original Article Source Type: research

Risk factors associated with respiratory disorders in late preterm infants
The Journal of Maternal-Fetal & Neonatal Medicine, Ahead of Print. (Source: Journal of Maternal-Fetal and Neonatal Medicine)
Source: Journal of Maternal-Fetal and Neonatal Medicine - February 25, 2015 Category: Perinatology & Neonatology Tags: article Source Type: research

Factors Associated with Intention to Receive Influenza and Tetanus, Diphtheria, and Acellular Pertussis (Tdap) Vaccines during Pregnancy: A Focus on Vaccine Hesitancy and Perceptions of Disease Severity and Vaccine Safety
This study has some important limitations. Since data were collected by self-report and not verified with medical records or vaccine registry data, there is potential for recall bias. Any recall bias which may have been introduced is assumed to have been non-differential with respect to characteristics likely to be associated with intention to receive antenatal influenza and/or Tdap vaccines. Additionally, while we excluded women who indicated having received an influenza and/or Tdap vaccine before completing her baseline survey, some women enrolled from intervention arm practices could have been exposed to the vaccine pro...
Source: PLOS Currents Outbreaks - February 25, 2015 Category: Epidemiology Authors: achamberlain Source Type: research