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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

A new chapter in therapy for cystic fibrosis
Publication date: Available online 24 June 2015 Source:The Lancet Respiratory Medicine Author(s): Diana Bilton (Source: The Lancet Respiratory Medicine)
Source: The Lancet Respiratory Medicine - June 26, 2015 Category: Respiratory Medicine Source Type: research

Achalasia with Megaesophagus and Tracheal Compression in a Young Patient: A Case Report
Conclusion This report emphasizes that physicians should be alert and consider airway obstruction and signs of dyspnea as severe and threatening symptoms in extensive cases of achalasia with megaesophagus. Early surgical treatment provides a therapeutic option to obviate the occurrence of acute respiratory distress and consecutive complications. In particular, difficulties in intubation prior to surgery must be considered. Due to potential tracheomalacia, the status of a “bull frog neck” in achalasia, including severe tracheal compression caused by megaesophagus with concomitant cervical swelling, may also lead to extu...
Source: International Journal of Surgery Case Reports - June 26, 2015 Category: Surgery Source Type: research

High risk of delisting or death in liver transplant candidates following infections: Results from the North American consortium for the study of end‐stage liver disease
Because Model for End‐Stage Liver Disease (MELD) scores at the time of liver transplantation (LT) increase nationwide, patients are at an increased risk for delisting by becoming too sick or dying while awaiting transplantation. We quantified the risk and defined the predictors of delisting or death in patients with cirrhosis hospitalized with an infection. North American Consortium for the Study of End‐Stage Liver Disease (NACSELD) is a 15‐center consortium of tertiary‐care hepatology centers that prospectively enroll and collect data on infected patients with cirrhosis. Of the 413 patients evaluated, 136 were lis...
Source: Liver Transplantation - June 26, 2015 Category: Transplant Surgery Authors: K. Rajender Reddy, Jacqueline G. O'Leary, Patrick S. Kamath, Michael B. Fallon, Scott W. Biggins, Florence Wong, Heather M. Patton, Guadalupe Garcia‐Tsao, Ram M. Subramanian, Leroy R. Thacker, Jasmohan S. Bajaj, Tags: Original Article Source Type: research

Molecular epidemiological analysis of Saffold cardiovirus genotype 3 from upper respiratory infection patients in Taiwan
Saffold cardiovirus (SAFV) belongs to the Cardiovirus genus of Picornaviridae family, which includes other pathogenic viruses involved in human hand, foot and mouth diseases (HFMD) such as enteroviruses [1,2]. The Cardiovirus genus includes two species: Theilovirus and Encephalomyocarditis virus. A newly identified Theilovirus named SAFV has been isolated from an 8-month-old child with fever of unknown origin in 2007 and designated as SAFV genotype 1 (SAFV-1) [1,3]. SAFV is distinct from Theiler’s murine encephalomyelitis virus (TMEV), Vilyuisk human encephyalomyelitis virus (VHEV) and Theiler-like rat virus (TRV) making...
Source: Journal of Clinical Virology - June 26, 2015 Category: Virology Authors: Tsuey-Li Lin, Ting-Han Lin, Shu-Chun Chiu, Yuan-Pin Huang, Cheng-Mao Ho, Chia-Chi Lee, Ho-Sheng Wu, Jih-Hui Lin Source Type: research

Markers for upper limb dysfunction in Amyotrophic Lateral Sclerosis using analysis of typing activity
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder involving upper and lower limb function, as well as bulbar and respiratory muscles (Andersen et al., 2012; Miller et al., 2013). Most ALS patients (85 to 90%) need assistive devices at some stage during disease progression, to assist in communication and social interaction (Beukelman et al., 2011; Brownlee and Bruening, 2012). Depending on disease stage, different interface technologies are required to enhance autonomy. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - June 26, 2015 Category: Neuroscience Authors: Ana Londral, Susana Pinto, Mamede de Carvalho Source Type: research

The Effect of Body Mass Index on Post-Vaccination Maternal and Neonatal Pertussis Antibody Levels
The bacterium, Bordatella pertussis, is responsible for pertussis, a highly contagious respiratory infection which most commonly affects young children. Pertussis is particularly dangerous to infants under one year of age who may present with periods of potentially fatal apnea (Cortese et al, 2008). The Centers for Disease Control (CDC) reported 48,277 cases of pertussis in 2012 in the United States, the highest reported number of cases since 1955 (CDC, 2012). Infants cannot be vaccinated against pertussis until approximately two months of age and are thus susceptible to pertussis during this time period. (Source: Journal ...
Source: Journal of Reproductive Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Manisha Gandhi, Sridevi Devaraj, Haleh Sangi-Haghpeykar, Joan Mastrobattista Source Type: research

Severe pulmonary hypertension is associated with altered right ventricle metabolic substrate uptake.
CONCLUSIONS: In the RV in rats with SPH, there is a major shift in metabolic substrate preference, largely due to decreased fatty acid uptake. PMID: 26115672 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - June 26, 2015 Category: Respiratory Medicine Authors: Graham BB, Kumar R, Mickael C, Sanders L, Gebreab L, Huber KM, Perez MJ, Smith-Jones P, Serkova NJ, Tuder RM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Junctional abnormalities in human airway epithelial cells expressing delF508 CFTR.
We examined changes to CFTR function, tight junctions, and gap junctions in NuLi-1 (CFTRwt/wt) and CuFi-5 (CFTRΔF508/ΔF508). Cells were studied at air-liquid interface (ALI) and compared to primary human bronchial epithelial cells. Based on fluorescent lectin binding, the phenotype of the NuLi-1 and CuFi-5 at week 8 resembled serous, glycoprotein-rich airway cells. After 7 weeks at ALI, CuFi-5 cells possessed 130% of the ENaC activity and 17% of the CFTR activity found in NuLi-1. In both cell types, expression levels of CFTR were comparable to CFTR levels found in primary airway epithelia. Transepithelial resistance (TER...
Source: Am J Physiol Lung Ce... - June 26, 2015 Category: Respiratory Medicine Authors: Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Phenotype of Normal Spirometry in an Aging Population.
CONCLUSION: GLI-defined normal spirometry, even when classified as respiratory impairment by GOLD, included adjusted mean values in the normal range for multiple phenotypes. These results suggest that among adults with GLI-defined normal spirometry, GOLD may misclassify normal phenotypes as having respiratory impairment. PMID: 26114439 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 26, 2015 Category: Respiratory Medicine Authors: Fragoso CA, McAvay G, Van Ness PH, Casaburi R, Jensen RL, MacIntyre N, Gill TM, Yaggi HK, Concato J Tags: Am J Respir Crit Care Med Source Type: research

First Human Challenge Testing of a Pneumococcal Vaccine - Double Blind Randomised Controlled Trial.
CONCLUSIONS: PCV reduced pneumococcal colonisation rate, density and duration in healthy adults. The experimental human pneumococcal colonisation model is a safe, cost-effective and efficient method to determine the protective efficacy of new vaccines on pneumococcal colonisation; PCV provides a 'gold standard' against which to test these novel vaccines. Clinical trial registration available at, ID 45340436. PMID: 26114410 [PubMed - as supplied by publisher] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - June 26, 2015 Category: Respiratory Medicine Authors: Collins AM, Wright AD, Mitsi E, Gritzfeld JF, Hancock CA, Pennington SH, Wang D, Morton B, Ferreira DM, Gordon SB Tags: Am J Respir Crit Care Med Source Type: research

Lysobacter agri sp. nov., a bacterium isolated from soil.
Abstract A bacterial strain, designated as THG-SKA3(T), was isolated from field soil of Kyung Hee University, South Korea. Cells of the isolate were observed to be Gram-negative, aerobic, rod-shaped and motile by gliding. The strain was found to grow optimally at 28 °C, at pH 7 and in absence of NaCl. Based on 16S rRNA gene sequence comparisons, strain THG-SKA3(T) shared highest sequence similarity with Lysobacter niastensis KACC 11588(T) followed by Lysobacter panacisoli KACC 17502(T), Lysobacter enzymogenes LMG 8762(T) and Lysobacter oryzae KCTC 22249(T). The G+C content of THG-SKA3(T) was determined to be 68.9...
Source: Antonie van Leeuwenhoek - June 26, 2015 Category: Microbiology Authors: Singh H, Won K, Du J, Yang JE, Akter S, Kim KY, Yi TH Tags: Antonie Van Leeuwenhoek Source Type: research

Flavobacterium notoginsengisoli sp. nov., isolated from the rhizosphere of Panax notoginseng.
Abstract Two novel bacterial strains, designated SYP-B540(T) and SYP-B556, were isolated from rhizospheric soil of Panax notoginseng located at Yunnan Province, China. Both strains were Gram-staining negative, aerobic, non-motile, elongated rod shaped and yellow coloured. They grew optimally at 28 °C and pH 7.0. Analysis of 16S rRNA gene sequences showed that the two strains shared 99.8 % sequence similarity to each other, but lower than 97.6 % to the other known species of the genus Flavobacterium. The predominant respiratory quinone for the two strains was MK-6, and the major fatty acids were iso-C15:0 and su...
Source: Antonie van Leeuwenhoek - June 26, 2015 Category: Microbiology Authors: Zhang MY, Xu H, Zhang TY, Xie J, Cheng J, Nimaichand S, Li SH, Li WJ, Zhang YX Tags: Antonie Van Leeuwenhoek Source Type: research

Respiratory variation in carotid peak systolic velocity predicts volume responsiveness in mechanically ventilated patients with septic shock: a prospective cohort study
Conclusions ΔCDPV can be more accurate than other methods for assessing fluid responsiveness in patients with septic shock receiving lung protective mechanical ventilation. ΔCDPV also has a high correlation with SVI increase after fluid challenge. (Source: Critical Ultrasound Journal)
Source: Critical Ultrasound Journal - June 26, 2015 Category: Radiology Source Type: research

The bacterial microbiota in inflammatory lung diseases.
Abstract Numerous lines of evidence, ranging from recent studies back to those in the 1920's, have demonstrated that the lungs are NOT bacteria-free during health. We have recently proposed that the entire respiratory tract should be considered a single ecosystem extending from the nasal and oral cavities to the alveoli, which includes gradients and niches that modulate microbiome dispersion, retention, survival and proliferation. Bacterial exposure and colonization of the lungs during health is most likely constant and transient, respectively. Host microanatomy, cell biology and innate defenses are altered during ...
Source: Clinical Immunology - June 26, 2015 Category: Allergy & Immunology Authors: Huffnagle GB, Dickson RP Tags: Clin Immunol Source Type: research

Middle East respiratory syndrome coronavirus in healthcare settings
Purpose of review: Attracting global attention, Middle East respiratory syndrome coronavirus (MERS-CoV) continues to cause sporadic cases and a potential risk of healthcare-associated infections. In this review, we highlight what is known about the risk of transmission within healthcare facilities and discuss interventions to halt its transmission within healthcare. Recent findings: MERS-CoV causes a wide range of infections from asymptomatic infections, mild or moderately symptomatic cases, to fatal disease. Two years after the initial reported case, MERS-CoV has caused limited disease outside the Arabian Peninsula with s...
Source: Current Opinion in Infectious Diseases - June 25, 2015 Category: Infectious Diseases Tags: NOSOCOMIAL AND HEALTHCARE RELATED INFECTIONS: Edited by Trish M. Perl Source Type: research

Risks to healthcare workers with emerging diseases: lessons from MERS-CoV, Ebola, SARS, and avian flu
Purpose of review: Several viral diseases have emerged and impacted healthcare systems worldwide. Healthcare personnels (HCPs) are at high risk of acquiring some emerging infections while caring for patients. We provide a review of risk factors, evidence of infection in HCPs, and prevention strategies with Middle East respiratory syndrome coronavirus, Ebola virus disease (Ebola), severe acute respiratory syndrome (SARS), and avian influenza. Recent findings: HCP-related infections with Middle East respiratory syndrome coronavirus, Ebola, and SARS have been reported among 1–27%, 2.5–12%, and 11–57% of total cases, res...
Source: Current Opinion in Infectious Diseases - June 25, 2015 Category: Infectious Diseases Tags: NOSOCOMIAL AND HEALTHCARE RELATED INFECTIONS: Edited by Trish M. Perl Source Type: research

Differential diagnosis of diffuse alveolar haemorrhage in immunocompromised patients
Purpose of review: Diffuse alveolar haemorrhage (DAH) is a life-threatening medical emergency in immunocompromised and immunocompetent patients characterized by haemoptysis, anaemia, acute respiratory failure and diffuse pulmonary infiltrates on radiologic examination. This review describes DAH imaging features, causes and main differential diagnosis. Recent findings: In immunosuppressed patients, DAH occurs most frequently in haematologic neoplasms, after haematopoietic stem cell transplantation or solid organ transplantation, secondary to drug reaction or infection, and associated with AIDS. However, differential diagnos...
Source: Current Opinion in Infectious Diseases - June 25, 2015 Category: Infectious Diseases Tags: INFECTIONS OF THE IMMUNOCOMPROMISED HOST: Edited by Jose G. Montoya Source Type: research

The role of colonoscopic screening in acromegaly revisited: review of current literature and practice guidelines
Conclusion Specific recommendations for large bowel endoscopic screening in patients with acromegaly have been proposed. In this comprehensive review we discuss the current state of knowledge and evidence on colonoscopic screening in patients with acromegaly illustrated by a case of aggressive colorectal cancer presenting late in a young woman with difficult to control acromegaly. (Source: Pituitary)
Source: Pituitary - June 25, 2015 Category: Endocrinology Source Type: research

Decreased general condition in the emergency department: high in-hospital mortality and a broad range of discharge diagnoses
Background: Decreased general condition (DGC) is a frequent presenting complaint within the Adaptive Triage Process. DGC describes a nonspecific decline in health and well-being, and it is common among elderly patients in the emergency department (ED). Aim: The aim of this study was to compare the in-hospital mortality among patients presenting with DGC with that among patients in the corresponding triage category presenting with other complaints to an ED. The secondary aim was to describe the discharge diagnoses of patients presenting with DGC. Methods: All patients admitted to Södersjukhuset from the ED in 2008 were inc...
Source: European Journal of Emergency Medicine - June 25, 2015 Category: Emergency Medicine Tags: Original Articles Source Type: research

Dosimetric Consequences of 3D Versus 4D PET/CT for Target Delineation of Lung Stereotactic Radiotherapy
Conclusions: Target delineation using 3D PET/CT without additional respiratory compensation techniques results in significant target underdosing in the context of SABR. (Source: Journal of Thoracic Oncology)
Source: Journal of Thoracic Oncology - June 25, 2015 Category: Cancer & Oncology Tags: Brief Reports Source Type: research

Impacts of Particulate Air Pollution on Asthma: Current Understanding and Future Perspectives.
Authors: Takizawa H Abstract The impacts of air pollution on human health and disease have been attracting attention, especially in industrialized countries and areas with heavy traffic burdens. Fine particulate matters (PMs) are considered as an important air pollutant, since it was reported that there was a significant relationship between PM2.5 levels and mortality by cohort studies in 1990s. Epidemiological and toxicological studies have strongly suggested a causative relationship between fine particulate air pollution and increased incidence as well as exacerbations of asthma, and other respiratory disorders. ...
Source: Recent Patents on Inflammation and Allergy Drug Discovery - June 25, 2015 Category: Allergy & Immunology Tags: Recent Pat Inflamm Allergy Drug Discov Source Type: research

Cigarette Smoke and Estrogen Signaling in Human Airway Smooth Muscle
Conclusion: These data suggest that CS induces dysregulation of estrogen signaling in ASM, which could contribute to increased airway contractility in women exposed to CS.Cell Physiol Biochem 2015;36:1101-1115 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - June 25, 2015 Category: Cytology Source Type: research

Mortality from myocardial infarction in chronic obstructive pulmonary disease: minding and mending the 'Gap'
Mounting evidence indicates that chronic obstructive pulmonary disease (COPD) is an independent risk factor for cardiovascular (CV) mortality. Data from several large trials such as the Lung Health Study, Towards a Revolution in COPD Health, Understanding Potential Long-term Impacts on Function with Tiotropium, European Respiratory Society Study on Chronic Obstructive Pulmonary Disease and Inhaled Steroids in Obstructive Lung Disease (ISOLDE) have shown that fatal CV events contribute to a major portion (between 22% and 39%) of the deaths in this population.1 Patients with COPD have greater mortality, rehospitalisation rat...
Source: Heart - June 25, 2015 Category: Cardiology Authors: Rajagopalan, S., Brook, R. D. Tags: Drugs: cardiovascular system, Interventional cardiology, Acute coronary syndromes, Percutaneous intervention, Clinical diagnostic tests, Epidemiology, Tobacco use Editorials Source Type: research

The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission
(Source: Eurosurveillance)
Source: Eurosurveillance - June 25, 2015 Category: Infectious Diseases Source Type: research

Implementing a Declination Form Program To Improve Influenza Vaccine Uptake by Staff in Department of Veterans Affairs Spinal Cord Injury Centre: A pilot study
Conclusion Use of local teams and consensus to identify strategies to implement a DFP is feasible and effective for achieving moderate-to-high levels of participation in the programme. (Source: Journal of Hospital Infection)
Source: Journal of Hospital Infection - June 25, 2015 Category: Infectious Diseases Source Type: research

Clinical Outcomes Associated With Respiratory Virus Detection Before Allogeneic Hematopoietic Stem Cell Transplant
Conclusions. These data support routine testing for respiratory viruses among symptomatic patients before HCT, and delay of transplant with virus detection when feasible, even for detection of rhinovirus alone. Further study is needed to address whether asymptomatic patients should undergo screening for respiratory virus detection before HCT. (Source: Clinical Infectious Diseases)
Source: Clinical Infectious Diseases - June 25, 2015 Category: Infectious Diseases Authors: Campbell, A. P., Guthrie, K. A., Englund, J. A., Farney, R. M., Minerich, E. L., Kuypers, J., Corey, L., Boeckh, M. Tags: ARTICLES AND COMMENTARIES Source Type: research

Infantile form of muscle phosphofructokinase deficiency in a premature neonate
We report the case of a preterm female infant who was diagnosed with the infantile form of phosphofructokinase deficiency due to a lack of PFK activity in her muscles, manifesting at a corrected age of 1 month as floppy infant syndrome, congenital joint contracture, cleft palate and duplication of the pelvicalyceal system. She died at a corrected age of 6 months due to respiratory failure. We further reviewed other infantile cases in the literature. Congenital hypotonia (78.6%), arthrogryposis (64.3%) and other systemic involvement including encephalopathy (35.7%) and cardiomyopathy (21.4%) are common presentations of the ...
Source: Pediatrics International - June 25, 2015 Category: Pediatrics Authors: Pei‐Ling Wu, Yung‐Ning Yang, Shu‐Leei Tey, Chun‐Hwa Yang, San‐Nan Yang, Chien‐Seng Lin Tags: Patient Report Source Type: research

Prevalence of respiratory virus in symptomatic children in private physician office settings in five communities of the state of Veracruz, Mexico
Conclusions: A large proportion of respiratory infections in the community setting in Mexico was associated to viruses. Although testing for common respiratory pathogens in children with acute respiratory tract infections may lead to a better understanding of the role of viral pathogens in, and eventually to improvement in the management of, individual patients, additional prospective studies are required to study the need of routinely using such tests in general pediatric practices in resource-limited countries. (Source: BMC Research Notes)
Source: BMC Research Notes - June 25, 2015 Category: Research Authors: Rosa Wong-ChewMarco EspinozaBlanca TaboadaFernando AponteMaría Arias-OrtizJesús Monge-MartínezRubén Rodríguez-VázquezFidel Díaz-HernándezFernando Zárate-VidalJosé Santos-PreciadoSusana LópezCarlos Arias Source Type: research

In the end it's a replication problem: What measuring telomere length can tell us about idiopathic pulmonary fibrosis
(Source: Respirology)
Source: Respirology - June 25, 2015 Category: Respiratory Medicine Authors: Daniel C. Chambers Tags: Editorial Source Type: research

IL - 10 and IL - 17F Promoter Single Nucleotide Polymorphism and Asthma: A Case-Control Study in South India
Conclusion We observed an association between IL-10 rs1800871 and rs1800896 SNPs and mild asthma, as well as IL-17F rs1887570 AA variant and number of allergens sensitized. (Source: Lung)
Source: Lung - June 25, 2015 Category: Respiratory Medicine Source Type: research

Pulmonary arterial wall thickness in Eisenmenger Syndrome: Prospective, cross‐sectional, controlled clinical trial
ConclusionPAWT can be used as an additional parameter with other echocardiographic parameters in the follow‐up of Eisenmenger Syndrome in children. Pediatr Pulmonol. © 2015 Wiley Periodicals, Inc. (Source: Pediatric Pulmonology)
Source: Pediatric Pulmonology - June 25, 2015 Category: Respiratory Medicine Authors: Nazmi Narin, Abdullah Ozyurt, Suleyman Sunkak, Ali Baykan, Mustafa Argun, Ozge Pamukcu, Kazim Uzum Tags: Original Article Source Type: research

Tuberculosis: A disease without boundaries
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis (MTB) that usually affects the lungs leading to severe coughing, fever, and chest pains. Although current research in the past four years has provided valuable insight into TB transmission, diagnosis, and treatment, much remains to be discovered to effectively decrease the incidence of and eventually eradicate TB. The disease still puts a strain on public health, being only second to HIV/AIDS in causing high mortality rates. (Source: Tuberculosis)
Source: Tuberculosis - June 25, 2015 Category: Respiratory Medicine Authors: Nicole Fogel Tags: Review Source Type: research

Prognostic value of variables derived from the six-minute walk test in patients with COPD: results from the ECLIPSE study
In addition to the six-min walk distance (6MWD), other six-min walk test (6MWT) derived variables, such as mean walk-speed (6MWSpeed), 6-min walk-work (6MWW), distance-saturation product (DSP), exercise-induced oxygen desaturation (EID), and unintended stops may be useful for the prediction of mortality and hospitalization in patients with chronic obstructive pulmonary disease (COPD). We studied the association between 6MWT-derived variables and mortality as well as hospitalization in COPD patients and compared it with the BODE index. (Source: Respiratory Medicine CME)
Source: Respiratory Medicine CME - June 25, 2015 Category: Respiratory Medicine Authors: Vasileios Andrianopoulos, Emiel F.M. Wouters, Victor M. Pinto-Plata, Lowie E.G.W. Vanfleteren, Per S. Bakke, Frits M.E. Franssen, Alvar Agusti, William MacNee, Stephen I. Rennard, Ruth Tal-Singer, Ioannis Vogiatzis, Jørgen Vestbo, Bartolome R. Celli, Mar Tags: Clinical Trial Paper Source Type: research

The Impact of Cystic Fibrosis Transmembrane Regulator Disruption on Cardiac Function and Stress Response
Altered cardiac function has been observed in cystic fibrosis transmembrane regulator (CFTR) knockout mice. However, whether this alteration is a direct effect of CFTR disruption in the heart, or is secondary due to systemic loss of CFTR, remains to be elucidated. (Source: Journal of Cystic Fibrosis)
Source: Journal of Cystic Fibrosis - June 25, 2015 Category: Respiratory Medicine Authors: Kai Jiang, Sen Jiao, Megan Vitko, Rebecca Darrah, Chris A. Flask, Craig A. Hodges, Xin Yu Tags: Original Article Source Type: research

Repetitive Nerve Stimulation and Single Fiber EMG in the Evaluation of Patients with Suspected Myasthenia Gravis or Lambert‐Eaton Myasthenic Syndrome: Review of Recent Literature
This article is protected by copyright. All rights reserved. (Source: Muscle and Nerve)
Source: Muscle and Nerve - June 25, 2015 Category: Internal Medicine Authors: Faye Y. Chiou‐Tan, James M. Gilchrist Tags: AANEM Technology Review Source Type: research

Obstructive sleep apnea and acute respiratory failure due to pneumonia: A protective factor to mortality risk?
Dear Editor, (Source: Journal of Critical Care)
Source: Journal of Critical Care - June 25, 2015 Category: Intensive Care Authors: Raymonde Jean, Charlisa Gibson, Raymond Jean, Pius Ochieng Source Type: research

Extracorporeal carbon dioxide removal in patients with chronic obstructive pulmonary disease: a systematic review
Conclusion The technique is still experimental and no randomized trial is available. Recognizing selection bias associated with case series, there still appears to be potential for benefit of ECCO2R in patients with COPD exacerbations. However, it is associated with frequent and potentially severe complications. Higher-quality studies are required to better elucidate this risk–benefit balance. (Source: Intensive Care Medicine)
Source: Intensive Care Medicine - June 25, 2015 Category: Intensive Care Source Type: research

Pi Effects on Mitochondrial Ca2+ [Metabolism]
The large inner membrane electrochemical driving force and restricted volume of the matrix confer unique constraints on mitochondrial ion transport. Cation uptake along with anion and water movement induces swelling if not compensated by other processes. For mitochondrial Ca2+ uptake, these include activation of countertransporters (Na+/Ca2+ exchanger and Na+/H+ exchanger) coupled to the proton gradient, ultimately maintained by the proton pumps of the respiratory chain, and Ca2+ binding to matrix buffers. Inorganic phosphate (Pi) is known to affect both the Ca2+ uptake rate and the buffering reaction, but the role of anio...
Source: Journal of Biological Chemistry - June 25, 2015 Category: Chemistry Authors: Wei, A.-C., Liu, T., O'Rourke, B. Tags: Bioenergetics Source Type: research

Differential regulation of metabolic parameters by energy deficit and hunger
: Hypocaloric diet decreases both energy expenditure (EE) and respiratory exchange rate (RER), affecting the efficacy of dieting inversely. Energy deficit and hunger may be modulated separately both in human and animal studies by drug treatment or food restriction. Thus it is important to separate the effects of energy deficit and hunger on EE and RER. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - June 25, 2015 Category: Biomedical Science Authors: Tamás Kitka, Sebestyén Tuza, Balázs Varga, Csilla Horváth, Péter Kovács Source Type: research

Predictors of All-Cause Mortality in Patients with Severe COPD and Major Depression Admitted to a Rehabilitation Hospital.
Conclusions: Recent falls and dyspnea during activities identify subgroups of depressed COPD patients at increased risk for all-cause mortality. These subgroups are in need of clinical attention and follow-up and can serve as targets for prevention research aiming to inform clinical strategies and public health planning. PMID: 26111347 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: Yohannes AM, Raue PJ, Kanellopoulos D, McGovern A, Sirey JA, Kiosses DN, Banerjee S, Seirup JK, Novitch RS, Alexopoulos GS Tags: Chest Source Type: research

Short Term Exposure to Ambient Fine Particulate Matter (PM2.5) Increases Hospitalizations and Mortality of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.
Conclusions: Our combined analysis indicated that short-term exposure to 10 μg/m3 increment of ambient PM2.5 is associated with increased COPD hospitalizations and mortality. Further study is needed to elucidate to which extent this relationship is causal together with other factors and to elucidate the mechanism by which PM2.5 induces activation of cellular processes promoting COPD exacerbations. PMID: 26111257 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: Li MH, Fan LC, Mao B, Yang JW, Choi AM, Cao WJ, Xu JF Tags: Chest Source Type: research

Effective Bronchoscopic Lung Volume Reduction Accelerates Exercise Oxygen Uptake Kinetics in Emphysema.
Conclusion: Lung deflation induced by e-BLVR accelerated exercise V.O2 kinetics in patients with emphysema. This beneficial effect appears to be related mechanistically to an enhanced cardiovascular response to exercise which may contribute to improved functional capacity. PMID: 26111199 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: Faisal A, Zoumot Z, Shah PL, Neder JA, Polkey MI, Hopkinson NS Tags: Chest Source Type: research

VTE Incidence and Risk Factors in Patients with Severe Sepsis and Septic Shock.
Conclusions: This is the first multicenter prospective study to identify a high incidence of VTE in patients with severe sepsis and septic shock, despite the use of universal, guideline-recommended thromboprophylaxis. Our findings suggest that the systemic inflammatory milieu of sepsis may uniquely predispose septic patients to VTE. More effective VTE prevention strategies are necessary in septic patients. PMID: 26111103 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: Kaplan D, Casper TC, Elliott CG, Men S, Pendleton RC, Kraiss LW, Weyrich AS, Grissom CK, Zimmerman GA, Rondina MT Tags: Chest Source Type: research

The Idiopathic Pulmonary Fibrosis Clinical Research Network (IPFnet): Diagnostic and Adjudication Processes.
Conclusions: The IPFnet diagnostic process was generally efficient, but a multidisciplinary adjudication committee was critical to assure correct phenotype for study enrollment. The AC was key in adjudicating all adverse outcomes in two IPFnet studies terminated early due to safety issues. Future clinical trials in IPF should consider logistical and cost issues as they incorporate AEx and hospitalizations as outcome measures. PMID: 26111071 [PubMed - as supplied by publisher] (Source: Chest)
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: de Andrade J, Schwarz M, Collard HR, Gentry-Bumpass T, Colby T, Lynch D, Kaner R, IPFnet Investigators Tags: Chest Source Type: research

ICD-10-CM for the PULMONARY, CRITICAL CARE & SLEEP PHYSICIAN. Chest. 2015 Jun 25; Authors: Plummer AL Abstract After a patient encounter, the physician uses two coding systems to bill for the service rendered to the patient. CPT is used to describe the encounter or procedure. ICD-9-CM is used to describe the diagnosis(es) of the patient. On October 1, 2015, ICD-9-CM will end and all physicians will be required to use a new diagnostic coding system, ICD-10-CM. This paper describes the new diagnostic coding system and how it differs from old system. There are resources and costs involved for physicia...
Source: Chest - June 25, 2015 Category: Respiratory Medicine Authors: Plummer AL Tags: Chest Source Type: research