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This page shows you the most recent publications within this specialty of the MedWorm directory.

Type 1 Diabetes May Be Reversible With Immune Suppressor Protein
A professor in Melbourne, Australia, who is on a mission to find a cure for type 1 diabetes, believes that the answer, or part of it, lies with an immune suppressor protein called CD52. And if it works for type 1 diabetes, then it may well work for other immune disorders, such as multiple sclerosis and rheumatoid arthritis, where disruption in the balance different kinds of T cell in the immune system causes it to attack the body's own healthy tissue... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 20, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

Immunizations in Adults Taking DMARDsImmunizations in Adults Taking DMARDs
Which DMARDs can decrease vaccine efficacy or increase vaccine-associated risk? U.S. Pharmacist (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 20, 2013 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Blame your parents for bunion woes
(Wiley) A novel study reports that white men and women of European descent inherit common foot disorders, such as bunions (hallux valgus) and lesser toe deformities, including hammer or claw toe. Findings from the Framingham Foot Study -- the first to estimate the heritability of foot disorders in humans -- appear in Arthritis Care & Research, a journal published by Wiley on behalf of the American College of Rheumatology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 20, 2013 Category: Global & Universal Source Type: news

Immune protein could stop diabetes in its tracks
(Walter and Eliza Hall Institute) Melbourne researchers have identified an immune protein that has the potential to stop or reverse the development of type 1 diabetes in its early stages, before insulin-producing cells have been destroyed. The discovery has wider repercussions, as the protein is responsible for protecting the body against excessive immune responses, and could be used to treat, or even prevent, other immune disorders such as multiple sclerosis and rheumatoid arthritis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 19, 2013 Category: Global & Universal Source Type: news

MRI Useful For Predicting Failure Of Metal-On-Metal Hip Implants Before Symptoms Appear
Metal-on-metal hip implants can cause inflammation of the joint lining (synovitis) long before symptoms appear, and magnetic resonance imaging (MRI) can be used to identify this inflammation, according to a new study by researchers at Hospital for Special Surgery. The study, which appears in an upcoming issue of the Journal of Bone & Joint Surgery, demonstrates that MRI can be used to identify implants that are going to fail before people become symptomatic. "The study shows that synovitis exists in asymptomatic people in a fairly high prevalence," said Hollis Potter, M.D... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Specific peripheral B cell tolerance defects in patients with multiple sclerosis
Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. B cells have recently emerged as major contributors to disease pathogenesis, but the mechanisms responsible for the loss of B cell tolerance in patients with MS are largely unknown. In healthy individuals, developing autoreactive B cells are removed from the repertoire at 2 tolerance checkpoints during early B cell development. Both of these central and peripheral B cell tolerance checkpoints are defective in patients with rheumatoid arthritis (RA) and type 1 diabetes (T1D). Here, we found that only the peripheral, but not t...
Source: Journal of Clinical Investigation - May 16, 2013 Category: Biomedical Science Authors: Tuure Kinnunen, Nicolas Chamberlain, Henner Morbach, Tineke Cantaert, Megan Lynch, Paula Preston-Hurlburt, Kevan C. Herold, David A. Hafler, Kevin C. O’Connor, Eric Meffre Source Type: research

Gout: No Help From Vitamin C Gout: No Help From Vitamin C
In patients with gout, vitamin C supplementation at 500 mg/day, either alone or with allopurinol, did not reduce uric acid levels enough to be clinically significant. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 16, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Xofigo Approved for Prostate Cancer
When disease has spread to the bones (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 16, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Pharmacy, Rheumatology, FDA Approvals, Source Type: news

Vitamin C Does Not Lower Uric Acid Levels In Gout Patients
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout. Vitamin C supplementation, alone or in combination with allopurinol, appears to have a weak effect on lowering uric acid levels in gout patients according to the results published in the American College of Rheumatology (ACR) journal, Arthritis & Rheumatism... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Gout Source Type: news

Combo Drug Therapy May Work Best to Strengthen Bones: Study
Title: Combo Drug Therapy May Work Best to Strengthen Bones: StudyCategory: Health NewsCreated: 5/15/2013 2:35:00 PMLast Editorial Review: 5/16/2013 12:00:00 AM (Source: MedicineNet Arthritis General)
Source: MedicineNet Arthritis General - May 16, 2013 Category: Rheumatology Source Type: news

Vitamin C does not lower uric acid levels in gout patients
(Wiley) Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout. Vitamin C supplementation, alone or in combination with allopurinol, appears to have a weak effect on lowering uric acid levels in gout patients according to the results published in the American College of Rheumatology journal, Arthritis & Rheumatism. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2013 Category: Global & Universal Source Type: news

Antiprotozoal and antimycobacterial activities of Persea americana seeds
Background: Persea americana seeds are widely used in traditional Mexican medicine to treat rheumatism, asthma, infectious processes as well as diarrhea and dysentery caused by intestinal parasites. Methods: The chloroformic and ethanolic extracts of P. americana seeds were prepared by maceration and their amoebicidal, giardicidal and trichomonicidal activity was evaluated. These extracts were also tested against Mycobacterium tuberculosis H37Rv, four mono-resistant and two multidrug resistant strains of M. tuberculosis as well as five non tuberculosis mycobacterium strains by MABA assay. Results: The chloroformic and etha...
Source: BMC Complementary and Alternative Medicine - May 16, 2013 Category: Complementary Medicine Authors: Adelina Jiménez-ArellanesJulieta Luna-HerreraRicardo Ruiz-NicolásJorge Cornejo-GarridoAmparo TapiaLilián Yépez-Mulia Source Type: research

Anti-inflammatory, antioxidant, and antimicrobial activities of Cocos nucifera var. typica
Conclusions: The extract exhibits anti-inflammatory activity through the inhibition of the cell migration. The mixture of extract constituents and methicillin could lead to the development of a new combination antibiotic against MRSA infections. (Source: BMC Complementary and Alternative Medicine)
Source: BMC Complementary and Alternative Medicine - May 16, 2013 Category: Complementary Medicine Authors: Rafaela SilvaDavi e SilvaHumberto FontesCeluta AlvianoPatricia FernandesDaniela Alviano Source Type: research

Early Consultation With a Rheumatologist for RAEarly Consultation With a Rheumatologist for RA
Does early consultation with a rheumatologist for RA reduce the future need for orthopedic surgery? Rheumatology (Source: Medscape Rheumatology Headlines)
Source: Medscape Rheumatology Headlines - May 15, 2013 Category: Rheumatology Tags: Rheumatology Journal Article Source Type: news

Simponi OK'd for Ulcerative Colitis
(MedPage Today) -- SILVER SPRING, Md. -- The biologic drug golimumab (Simponi) may be used to treat moderate to severe ulcerative colitis, the FDA said Wednesday. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - May 15, 2013 Category: Rheumatology Source Type: news

Materials in Some Household Products Tied to Lung Damage
Breathing in 'nanomaterials' seems to cause inflammation, study contends (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - May 15, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Family Medicine, Pulmonology, Rheumatology, Preventive Medicine, News, Source Type: news

Some Types of Skin Cancer Linked to Lower Chances of Alzheimer’s
A weak immune response might allow skin cancer but protect brain from inflammation, expert suggests (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 15, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Neurology, Oncology, Rheumatology, Geriatrics, News, Source Type: news

Judge: Reliance On Employability Analysis, Record Reviews Reasonable
NASHVILLE, Tenn. - An ERISA-governed disability insurer that terminated benefits to a claimant with arthritis acted reasonably, a Tennessee federal judge ruled May 6 (Arlene Cook v. The Hartford, et al., No. 3-12-0749, M.D. Tenn.; 2013 U.S. Dist. LEXIS 64125). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - May 15, 2013 Category: Medical Law Source Type: news

Benefit Denial Was Abuse Of Discretion, Judge Holds
SALT LAKE CITY - An ERISA-governed disability insurer that denied benefits to a claimant with chronic obstructive pulmonary disease, back pain and arthritis abused its discretion, a Utah federal judge ruled April 24 (Cheryl E. Krum v. Hartford Life and Accident Insurance Co., No. 2:11-932, D. Utah; 2013 U.S. Dist. LEXIS 58909). (Source: LexisNexis® Mealey's™ Disability Insurance Legal News)
Source: LexisNexis® Mealey's™ Disability Insurance Legal News - May 15, 2013 Category: Medical Law Source Type: news

Sanofi recruits patients for arthritis trials
PARIS (Reuters) - French drugmaker Sanofi SA said it and U.S. firm Regeneron Pharmaceuticals have started recruiting patients for two new trials of their arthritis treatment sarilumab. (Source: Reuters: Health)
Source: Reuters: Health - May 15, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Systemic {alpha}-melanocyte-stimulating hormone administration decreases arthritis-induced anorexia and muscle wasting
In conclusion our data show that in arthritic rats peripheral α-MSH treatment has an anti-cachectic action increasing food intake and decreasing muscle wasting. (Source: AJP: Regulatory, Integrative and Comparative Physiology)
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 15, 2013 Category: Physiology Authors: Gomez-SanMiguel, A. B., Martin, A. I., Nieto-Bona, M. P., Fernandez-Galaz, C., Lopez-Menduina, M., Villanua, M. A., Lopez-Calderon, A. Tags: Hormones, Reproduction and Development Source Type: research

CD161 expression characterizes a sub‐population of human regulatory T cells that produces IL‐17 in a STAT3 dependent manner
This article is protected by copyright. All rights reserved (Source: European Journal of Immunology)
Source: European Journal of Immunology - May 15, 2013 Category: Allergy & Immunology Authors: Behdad Afzali, Peter J Mitchell, Francis C. Edozie, Giovanni AM Povoleri, Sophie E Dowson, Laura Demandt, Gina Walter, James B Canavan, Cristiano Scotta, Bina Menon, Prabhjoat S Chana, Wafa Khamri, Shahram Y Kordasti, Susanne Heck, Bodo Grimbacher, Timoth Tags: Regular Article Source Type: research

Personalized Medicine for OsteoarthritisPersonalized Medicine for Osteoarthritis
This review reports on the important developments in personalized medicine for the diagnosis and management of osteoarthritis. Therapeutic Advances in Musculoskeletal Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 14, 2013 Category: Consumer Health News Tags: Rheumatology Journal Article Source Type: news

Ilaris® Approved By FDA To Treat Active Systemic Juvenile Idiopathic Arthritis, A Serious Form Of Childhood Arthritis
Ilaris® (canakinumab) is the first interleukin-1 beta inhibitor for the treatment of SJIA and the only treatment approved specifically for SJIA that is given as a monthly subcutaneous injection1. In Phase III studies, 84% of Ilaris-treated SJIA patients achieved significant improvement of systemic and arthritic symptoms (pediatric ACR30) after a single subcutaneous dose1 Novartis has announced that the US Food and Drug Administration (FDA) has approved Ilaris® (canakinumab) for the treatment of active systemic juvenile idiopathic arthritis (SJIA) in patients aged 2 years and older... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 14, 2013 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Haemodynamically irrelevant pericardial effusion is associated with increased mortality in patients with chronic heart failure
Conclusion In chronic heart failure, even minor PEs are associated with an increased risk of all-cause mortality, cardiac death, and need for transplantation. (Source: European Heart Journal)
Source: European Heart Journal - May 14, 2013 Category: Cardiology Authors: Frohlich, G. M., Keller, P., Schmid, F., Wolfrum, M., Osranek, M., Falk, C., Noll, G., Enseleit, F., Reinthaler, M., Meier, P., Luscher, T. F., Ruschitzka, F., Tanner, F. C. Tags: Heart failure/cardiomyopathy Source Type: research

A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose
In vitro bovine cartilage punch model is a novel tool developed to evaluate potential bio-materials for use in cartilage regeneration and repair. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - May 14, 2013 Category: Rheumatology Authors: David PretzelStefanie LinssHannes AhremMichaela EndresChristian KapsDieter KlemmRaimund Kinne Source Type: research

Ilaris® approved by FDA
Novartis announced today that the US Food and Drug Administration (FDA) has approved Ilaris® (canakinumab) for the treatment of active systemic juvenile idiopathic arthritis (SJIA) in patients aged two years and older. Ilaris is the first interleukin-1 beta (IL-1 beta) inhibitor approved for SJIA and the only treatment approved specifically for SJIA that is given as a once-monthly subcutaneous injection. (Source: Pharmacy Europe)
Source: Pharmacy Europe - May 13, 2013 Category: Drugs & Pharmacology Source Type: news

Fat Triggers Rheumatoid Arthritis: Discovery Paves Way For New Gene Therapies, Treatments
Scientists have discovered that fat cells in the knee secrete a protein linked to arthritis, a finding that paves the way for new gene therapies that could offer relief and mobility to millions worldwide. ar "We found that fat in the knee joints secretes a protein called pro-factor D which gives rise to another protein known as factor D that is linked to arthritis," said Nirmal Banda, Ph.D., associate professor of medicine in the Division of Rheumatology at the University of Colorado School of Medicine. "Without factor D, mice cannot get rheumatoid arthritis... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 13, 2013 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

Streptococcal‐vimentin cross‐reactive antibodies induce microvascular cardiac endothelial proinflammatory phenotype in Rheumatic Heart Disease
In conclusion streptococcal‐vimentin cross‐reactive antibodies were able to activate microvascular cardiac endothelium by amplifying inflammatory response in RHD. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - May 13, 2013 Category: Allergy & Immunology Authors: Federica Delunardo, Valentina Scalzi, Antonella Capozzi, Serena Camerini, Roberta Misasi, Marina Pierdominici, Monica Pendolino, Marco Crescenzi, Maurizio Sorice, Guido Valesini, Elena Ortona, Cristiano Alessandri Tags: Original Article Source Type: research

Methotrexate/iatrogenic lymphoproliferative disorders in rheumatoid arthritis: histology, Epstein–Barr virus, and clonality are important predictors of disease progression and regression
ConclusionsHistology, EBV positivity, and monoclonality of IGH are useful for predicting clinical outcomes in patients with RA‐LPD. (Source: European Journal of Haematology)
Source: European Journal of Haematology - May 13, 2013 Category: Hematology Authors: Ayako Ichikawa, Fumiko Arakawa, Junichi Kiyasu, Kensaku Sato, Hiroaki Miyoshi, Daisuke Niino, Yoshizo Kimura, Masanori Takeuchi, Maki Yoshida, Yukinao Ishibashi, Shinji Nakashima, Yasuo Sugita, Osamu Miura, Koichi Ohshima Tags: Original Article Source Type: research

Inheritance of autoinflammatory diseases: shifting paradigms and nomenclature
Over 15 years have passed since the discovery of the first autoinflammatory gene, MEFV, responsible for familial Mediterranean fever. The identification of another gene, TNFRSF1A, in 1999 led to the concept of autoinflammation which characterises rheumatological conditions triggered by a defective innate immunity. Substantive progress has been made since then with the identification of 18 autoinflammatory genes accounting for up to 24 disease entities showing overlapping symptoms. The accumulation of studies reporting patients with missing or excess mutations as compared with expected numbers favours the hypothesis th...
Source: Journal of Medical Genetics - May 13, 2013 Category: Genetics & Stem Cells Authors: Touitou, I. Tags: Editor's choice, Immunology (including allergy) Immune genetics Source Type: research

Fibromyalgia Guidelines Trigger Changes for FPsFibromyalgia Guidelines Trigger Changes for FPs
Fibromyalgia diagnosis does not need extensive testing, treatment includes drug and nondrug therapies, and FM symptoms are easily faked, sometimes for financial gain, Canadian guidelines say. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 11, 2013 Category: Consumer Health News Tags: Rheumatology News Source Type: news

What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us?
(Source: Rheumatology)
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Inaba, S., Sautin, Y., Garcia, G. E., Johnson, R. J. Tags: Crystal Arthritis EDITORIALS Source Type: research

Corticosteroid injections in osteoarthritis: should we care about predicting response?
(Source: Rheumatology)
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Conaghan, P. G. Tags: Osteoarthritis and Cartilage EDITORIALS Source Type: research

Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management
A finding of high BMD on routine DXA scanning is not infrequent and most commonly reflects degenerative disease. However, BMD increases may also arise secondary to a range of underlying disorders affecting the skeleton. Although low BMD increases fracture risk, the converse may not hold for high BMD, since elevated BMD may occur in conditions where fracture risk is increased, unaffected or reduced. Here we outline a classification for the causes of raised BMD, based on identification of focal or generalized BMD changes, and discuss an approach to guide appropriate investigation by clinicians after careful interpretation of...
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Gregson, C. L., Hardcastle, S. A., Cooper, C., Tobias, J. H. Tags: Osteoarthritis and Cartilage, Spondylarthropathies, Osteoporosis and Metabolic Bone Disease REVIEWS Source Type: research

An overlooked cause of back pain and stiffness
(Source: Rheumatology)
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Gualtierotti, R., De Marco, G., Marchesoni, A. Tags: Osteoarthritis and Cartilage CLINICAL VIGNETTES Source Type: research

Subcutaneous abatacept for the treatment of rheumatoid arthritis
The efficacy, safety and tolerability of i.v. abatacept are well established in patients with active RA. A s.c. abatacept formulation is now available in some countries. Here, we review clinical data for s.c. abatacept. Six trials are presented (Phase II dose-finding study, ACQUIRE, ALLOW, ACCOMPANY, ATTUNE and AMPLE) and issues important to both patients and clinicians are addressed. The primary focus assesses whether the i.v. and s.c. abatacept formulations have similar efficacy, including whether the recommended fixed dose of s.c. abatacept is comparable to the weight-tiered i.v. dosing and whether efficacy is sustained...
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Schiff, M. Tags: Pharmacology, Rheumatoid Arthritis REVIEWS Source Type: research

Delphinidin inhibits IL-1{beta}-induced activation of NF-{kappa}B by modulating the phosphorylation of IRAK-1Ser376 in human articular chondrocytes
Conclusion. These data identify delphinidin as a novel inhibitor of IL-1β-induced production of cartilage-degrading molecule PGE2 via inhibition of COX-2 expression and provide new insight into the mechanism of its action. Our results also identify inhibition of IRAK1Ser376 phosphorylation by delphinidin in IL-1β-induced activation of NF-B in human chondrocytes. Given the important role played by IL-1β-induced NF-B activation, COX-2 expression and PGE2 production in OA, our results may have important implications for the development of novel therapeutic strategies for the prevention/treatment of OA. (Source: Rheumatology)
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Haseeb, A., Chen, D., Haqqi, T. M. Tags: Osteoarthritis and Cartilage BASIC SCIENCE Source Type: research

Three-pointed star sign of lupus enteritis
(Source: Rheumatology)
Source: Rheumatology - May 11, 2013 Category: Rheumatology Authors: Kamata, Y., Minota, S. Tags: Systemic Lupus Erythematosus and Autoimmunity CLINICAL VIGNETTES Source Type: research