Rheumatology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 26.

[A woman in her thirties with pain in her fingers and toes].
We describe the first case of Chikungunya fever diagnosed in our hospital. PMID: 23160592 [PubMed - in process]
Source: Tidsskrift for den Norske Laegeforening - November 12, 2012 Category: Journals (General) Authors: Power OA, Brun JG, Blomberg B Tags: Tidsskr Nor Laegeforen Source Type: research

Comparative Multidatabase Analysis of Dosing Patterns and Infusion Intervals for the First 12 Infliximab Infusions in Patients With Rheumatoid Arthritis.
CONCLUSION: Data from multiple databases of patients with RA suggest that, in clinical practice, infliximab dosing and intervals are consistent with FDA prescribing information and remain relatively stable during the first 12 infusions. PMID: 23153660 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - November 12, 2012 Category: Drugs & Pharmacology Authors: Bolge SC, Carter CT, Mueller CS, Bailey RA, Ingham MP Tags: Clin Ther Source Type: research

Comparison of the Clinical Expression of Patients with Ankylosing Spondylitis from Europe and Latin America.
CONCLUSION: The principal differences in the clinical manifestations of patients with AS from EU and LA were the greater frequency of peripheral arthritis and enthesitis in LA group, the higher percentage of HLA-B27 in EU group, and the form of treatment, with a greater use of NSAID, steroids, and DMARD in the LA group. PMID: 23149388 [PubMed - as supplied by publisher]
Source: J Rheumatol - November 12, 2012 Category: Rheumatology Authors: Benegas M, Muñoz-Gomariz E, Font P, Burgos-Vargas R, Chaves J, Palleiro D, Maldonado Cocco J, Gutiérrez M, Sáenz R, Steckmen I, Rillo O, Mulero J, Sampaio-Barros P, Barcelos A, Vander Cruyssen B, Vazquez-Mellado J, Collantes Estevez E Tags: J Rheumatol Source Type: research

The immunoreceptor tyrosine-based activation motif (ITAM) -related factors are increased in synovial tissue and vasculature of rheumatoid arthritic joints
Conclusions: Increased levels of ITAM related factors were present in synovial tissue from active RA joints compared to OA and healthy joints. OSCAR was strongly expressed by the vasculature of active RA patients and membrane bound and soluble OSCAR was stimulated by inflammatory mediators in endothelial cells in vitro.
Source: Arthritis Research and Therapy - November 12, 2012 Category: Rheumatology Authors: Tania CrottiAnak DharmapatniEkram AliasAndrew ZannettinoMalcolm SmithDavid Haynes Source Type: research

Screening for rheumatic heart disease: evaluation of a simplified echocardiography-based approach
Conclusion Simplified echocardiography-based screening for RHD appears feasible, allowing rapid and appropriate detection of a significant number of RHD cases on site.
Source: European Journal of Echocardiography - November 12, 2012 Category: Cardiology Authors: Mirabel, M., Celermajer, D. S., Ferreira, B., Tafflet, M., Perier, M.-C., Karam, N., Mocumbi, A.-O., Jani, D. N., Sidi, D., Jouven, X., Marijon, E. Tags: ORIGINAL PAPERS Source Type: research

Altered expression of intestinal human leucocyte antigen D-related and immune signalling molecules in juvenile idiopathic arthritis.
Abstract We aimed to study intestinal immune activation status in juvenile idiopathic arthritis (JIA) by assessing intestinal human leucocyte antigen (HLA) class II expression and the mRNA expression levels of the pro- and anti-inflammatory mediators and pattern recognition receptors. HLA-D-related (HLA-DR) expression was assessed using immunohistochemical staining of frozen sections in 11 children with JIA and 17 controls. The gene expression levels of the anti- and proinflammatory cytokines, lymphocyte recognition receptors and pattern recognition receptors were studied with reverse transcription-polymerase chain...
Source: Clinical and Developmental Immunology - November 11, 2012 Category: Allergy & Immunology Authors: Arvonen M, Vähäsalo P, Turunen S, Salo HM, Mäki M, Laurila K, Vaarala O, Karttunen TJ Tags: Clin Exp Immunol Source Type: research

4G/5G plasminogen activator inhibitor-1 and −308 A/G tumor necrosis factor-α promoter gene polymorphisms in Argentinean lupus patients: focus on lupus nephritis
Abstract We investigated the relationship between the 4G/5G plasminogen activator inhibitor (PAI-1) and −308 A/G tumor necrosis factor-α (TNF-α) polymorphisms and the clinical and biochemical features of systemic lupus erythematosus (SLE) in an Argentinean patient cohort. A total of 402 patients were studied, including 179 SLE patients and 223 healthy individuals. PCR-RLFP was used to determine the genotypes of the 4G/5G PAI-1 and −308 A/G TNF-α polymorphisms. SLE patients with lupus nephritis (LN) (n = 86) were compared with patients without LN (n = 93). Additionally, LN patients w...
Source: Clinical and Experimental Medicine - November 11, 2012 Category: Research Tags: Clinical and Experimental Medicine Source Type: research

Thalidomide reduces recurrence of ankylosing spondylitis in patients following discontinuation of etanercept
This study points to a new way for maintenance therapy of AS following discontinuation of etanercept and reveals several useful indicators for prediction of AS recurrence. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00296-012-2571-5Authors Xiaohu Deng, Department of Rheumatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaJianglin Zhang, Department of Rheumatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaJie Zhang, Department of Rheumatology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853 ChinaFeng Huang, Department of ...
Source: Rheumatology International - November 11, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability
Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability Nature 492, 7428 (2012). doi:10.1038/nature11603 Authors: Weiquan Zhu, Nyall R. London, Christopher C. Gibson, Chadwick T. Davis, Zongzhong Tong, Lise K. Sorensen, Dallas S. Shi, Jinping Guo, Matthew C. P. Smith, Allie H. Grossmann, Kirk R. Thomas & Dean Y. Li The innate immune response is essential for combating infectious disease. Macrophages and other cells respond to infection by releasing cytokines, such as interleukin-1β (IL-1β), which in turn activate a well-described, myeloid-d...
Source: Nature - November 11, 2012 Category: Research Authors: Weiquan ZhuNyall R. LondonChristopher C. GibsonChadwick T. DavisZongzhong TongLise K. SorensenDallas S. ShiJinping GuoMatthew C. P. SmithAllie H. GrossmannKirk R. ThomasDean Y. Li Tags: Letter Source Type: research

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
This study illustrates the advantages of dense SNP mapping analysis to inform subsequent functional investigations.
Source: Nature Genetics - November 11, 2012 Category: Genetics & Stem Cells Authors: Steve EyreJohn BowesDorothée DiogoAnnette LeeAnne BartonPaul MartinAlexandra ZhernakovaEli StahlSebastien ViatteKate McAllisterChristopher I AmosLeonid PadyukovRene E M ToesTom W J HuizingaCisca WijmengaGosia TrynkaLude FrankeHarm-Jan WestraLars Alfredss Tags: Letter Source Type: research

Interleukin receptor activates a MYD88–ARNO–ARF6 cascade to disrupt vascular stability
Nature advance online publication 11 November 2012. doi:10.1038/nature11603 Authors: Weiquan Zhu, Nyall R. London, Christopher C. Gibson, Chadwick T. Davis, Zongzhong Tong, Lise K. Sorensen, Dallas S. Shi, Jinping Guo, Matthew C. P. Smith, Allie H. Grossmann, Kirk R. Thomas & Dean Y. Li The innate immune response is essential for combating infectious disease. Macrophages and other cells respond to infection by releasing cytokines, such as interleukin-1β (IL-1β), which in turn activate a well-described, myeloid-differentiation factor 88 (MYD88)-mediated, nuclear factor-κB (NF-κB)-dependent transcrip...
Source: Nature AOP - November 11, 2012 Category: Research Authors: Weiquan ZhuNyall R. LondonChristopher C. GibsonChadwick T. DavisZongzhong TongLise K. SorensenDallas S. ShiJinping GuoMatthew C. P. SmithAllie H. GrossmannKirk R. ThomasDean Y. Li Tags: Letter Source Type: research

Interstitial lung disease in clinically amyopathic dermatomyositis (CADM) patients: a retrospective study of 41 Chinese Han patients
Abstract To study the clinical features and associated risk factors of interstitial lung disease (ILD) in clinically amyopathic dermatomyositis (CADM) in Chinese patients. Forty-one Chinese Han patients with a diagnosis of CADM in West China Hospital from August 2008 to 2011 were retrospectively analyzed. The prevalence of ILD in CADM patients is 60.98 %, in which 26.83 % for acute/subacute interstitial pneumonia (A/SIP) and 34.15 % for chronic interstitial pneumonia (CIP). Mortality of A/SIP is 63.64 %, with a 6-month survival rate of 54.50 %. Levels of erythrocyte sedimentation rat...
Source: Rheumatology International - November 10, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Effect of cyclophosphamide on cytokines in patients with primary Sjögren’s syndrome-associated interstitial lung disease in South China
The objective of the study is to investigate the mechanisms of cyclophosphamide sequential therapy for patient with primary Sjögren’s syndrome-associated interstitial lung disease (PSS-ILD). This was a retrospective review of 15 patients (2005–2008) with PSS-ILD who underwent cyclophosphamide sequential therapy. Peripheral blood and bronchoalveolar lavage (BALF) were obtained before and 3, 6, 12 and 24 months after the treatment. The TNF-α and TGF-β1 mRNA levels in peripheral blood were measured using reverse transcription polymerase chain reaction. Serum and BALF TNF-α, TGF-β1 and MMP-9 levels were measu...
Source: Rheumatology International - November 10, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Impairment and disability: Renoir's adaptive coping strategies against rheumatoid arthritis
Abstract Pierre-Auguste Renoir was one of the most influential painters in art history, but few people know that he suffered from debilitating rheumatoid arthritis. Despite his arthritis, he was able to maintain an incredible level of precision and efficiency with his painting. More importantly, he remained positive and did not let his condition affect his passion for painting or take away from the beauty that he saw in the world around him. Renoir applied a wide variety of coping mechanisms and used his ingenuity to come up with different ways to continue painting even as his arthritis weakened him. Renoir'...
Source: Hand - November 10, 2012 Category: Surgery Tags: Hand Source Type: research

Progranulin antibodies in autoimmune diseases.
Abstract Systemic vasculitides constitute a heterogeneous group of diseases. Autoimmunity mediated by B lymphocytes and their humoral effector mechanisms play a major role in ANCA-associated vasculitis (AAV) as well as in non-ANCA associated primary systemic vasculitides and in the different types of autoimmune connective tissue disorders and rheumatoid arthritis. In order to detect autoantibodies in systemic vasculitides, we screened protein macroarrays of human cDNA expression libraries with sera from patients with ANCA-associated and ANCA-negative primary systemic vasculitides. This approach led to the identific...
Source: Journal of Autoimmunity - November 10, 2012 Category: Allergy & Immunology Authors: Thurner L, Preuss KD, Fadle N, Regitz E, Klemm P, Zaks M, Kemele M, Hasenfus A, Csernok E, Gross WL, Pasquali JL, Martin T, Bohle RM, Pfreundschuh M Tags: J Autoimmun Source Type: research

Association analysis of single nucleotide polymorphisms of proinflammatory cytokine and their receptors genes with rheumatoid arthritis in northwest Chinese Han population.
CONCLUSIONS: This study demonstrated that PCR-HRM assay is a highly efficient SNP genotyping method especially for the detection of large-scale samples. The SNPs of TNFA-308 and TNFA-863 are closely associated with RA susceptibility and that gene-gene interactions may occur among the six SNPs of IL1B-31, IL1RN, IL6-572, IL6R-183, IL6R-exon1 and TNFA-857 in RA patients from northwest Chinese Han population, especially these SNPs' combination genotypes CT/TT/CC/GG/AC/CC, CT/TT/GC/AA/AC/CT and CT/CT/CC/GA/AC/CC to show high risk of RA susceptibility in our study. PMID: 23148991 [PubMed - as supplied by publisher]
Source: Cytokine - November 10, 2012 Category: Molecular Biology Authors: You CG, Li XJ, Li YM, Wang LP, Li FF, Guo XL, Gao LN Tags: Cytokine Source Type: research

Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot
Abstract Bone-marrow oedema (BME) represents a reversible but mostly painful increase in interstitial fluid. The exact pathogenetic processes still remain unknown. Treatment options are mainly symptomatic with core decompression as golden standard leading to immediate pain relieve. Recently, it has been shown that intravenous prostacyclin and bisphosphonates are useful in achieving a reduction in BME with a considerable improvement in the accompanying symptoms. We compared the outcome of both intravenously applied prostacyclin (Ilomedin®, 10 patients) and bisphosphonate (Bondronat®, 10 patients) in treatme...
Source: Rheumatology International - November 9, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Clinically silent Crohn’s disease in a patient with Takayasu’s Arteritis unresponsive to conventional therapies
Abstract Takayasu arteritis (TA) and Crohn’s disease (CD) are chronic inflammatory diseases with granulomatous nature. Here, we report a case of TA with a silent course of CD who was refractory to corticosteroid and immunosuppressive treatments and improved with adalimumab therapy. Content Type Journal ArticleCategory Short CommunicationPages 1-3DOI 10.1007/s00296-012-2558-2Authors Neslihan Yilmaz, Department of Rheumatology, Faculty of Medicine, Marmara University, Fevzi Cakmak Mah, Ust Kaynarca / Pendik, Istanbul, TurkeyMeryem Can, Department of Rheumatology, Faculty of Medicine, Marmara University,...
Source: Rheumatology International - November 9, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life
This study was carried out to determine the serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis (AS) and to evaluate its correlation with disease activity and quality of life. According to our knowledge, it is the first trial evaluating HMGB1 levels in AS. Serum samples of 30 patients (18 males and 12 females) with AS and 29 healthy controls (HC) (15 females and 14 males) were collected. HMGB1 levels were measured by enzyme-linked immunosorbent assay, activity of disease was assessed according to the Bath AS Disease Activity Index (BASDAI), and functional status of patients...
Source: Rheumatology International - November 9, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine
Abstract Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common musculoskeletal disease among people after middle age. The OPLL presents with serious neurological abnormalities due to compression of the spinal cord and nerve roots. The OPLL is caused by genetic and environment factors; however, its etiology and pathogenesis still remain to be elucidated. To determine the susceptibility loci for OPLL, we performed a genome-wide linkage study using 214 affected sib-pairs of Japanese. In stratification analyses for definite cervical OPLL, we found loci with suggestive linkage on 1p2...
Source: Journal of Bone and Mineral Metabolism - November 9, 2012 Category: Orthopaedics Tags: Journal of Bone and Mineral Metabolism Source Type: research

Do anti-TNF-α drugs increase cancer risk in rheumatoid arthritis patients?
Abstract Concern has been raised about an increased risk of lymphoma and skin cancers in patients with rheumatoid arthritis due to administration of anti-TNF-α drugs. Meta-analysis of observational data from registries as well as from randomized controlled trials has failed to show a significant increase in the risk of lymphoma when the sample size has been sufficiently large; skin cancer risk may represent a valid concern. Issues relating to interpretation of these data are discussed. Content Type Journal ArticleCategory CommentaryPages 1-3DOI 10.1007/s10787-012-0158-0Authors David A. Clark, Departme...
Source: Inflammopharmacology - November 9, 2012 Category: Drugs & Pharmacology Tags: Inflammopharmacology Source Type: research

Low-level laser therapy improves crescentic glomerulonephritis in rats
Abstract Low-level laser therapy (LLLT) can reduce inflammation in a variety of clinical conditions, including trauma, postherpetic neuralgia, and rheumatoid arthritis. However, the effect of LLLT on internal organs has not been elucidated. The goal of the present study was to investigate the anti-inflammatory effect of daily external LLLT in an animal model of crescentic glomerulonephritis. Crescentic glomerulonephritis was induced in male Wister Kyoto rats by intravenous injection of antibody for glomerular basement membrane (GBM). The rats were irradiated with a low-reactive level diode laser with an infr...
Source: Lasers in Medical Science - November 9, 2012 Category: Laser Surgery Tags: Lasers in Medical Science Source Type: research

Matrix-associated autologous chondrocyte transplantation in a compartmentalized early stage of osteoarthritis
In this study, a compartmentalized, early-stage OA was generated surgically in sheep stifle joints, and this model was used to evaluate a matrix-associated cell transplantation approach for cartilage repair.Method: Eighteen sheep were operated twice. During the first operation, a unicompartmental OA in a stable joint was induced by creating a critical-size defect. The second operation served as a regeneration procedure. The eighteen sheep were divided into three groups. One group was treated with spongialization (SPONGIO), while the two others had spongialization followed by implantation of a hyaluronan matrix with (MACT) ...
Source: Osteoarthritis and Cartilage - November 9, 2012 Category: Rheumatology Authors: M. Schinhan, M. Gruber, R. Dorotka, M. Pilz, D. Stelzeneder, C. Chiari, N. Rössler, R. Windhager, S. Nehrer Tags: Original Articles Source Type: research

Infliximab reduces CD147, MMP-3, and MMP-9 expression in peripheral blood monocytes in patients with active rheumatoid arthritis.
This report describes the inhibitory effects of infliximab on CD147 and metalloproteinases (MMP)-3 and MMP-9 overexpression in peripheral blood monocytes obtained from patients with active rheumatoid arthritis. Thirty patients with active rheumatoid arthritis that were refractory to methotrexate therapy were randomized at a 4:1 ratio into groups A and B, respectively. Group A received three to four infusions of infliximab (3mg/kg) and group B participants received four infusions of placebo. Both groups were also treated with a stable background dose of methotrexate. The CD147 expression levels on CD14(+) peripheral blood m...
Source: European Journal of Pharmacology - November 9, 2012 Category: Drugs & Pharmacology Authors: Huang JL, Xie BZ, Li QX, Xie XJ, Zhu S, Wang MX, Peng WX, Gu JR Tags: Eur J Pharmacol Source Type: research

Is Identification of Anti‐SSA and/or ‐SSB Antibodies Necessary in Serum Samples Referred for Antinuclear Antibodies Testing?
ConclusionIn conclusion, the identification of anti‐SSA and ‐SSB antibodies is necessary, when corresponding diseases are suspected. The specificity of anti‐SSA for the diagnosis of SS could be improved, when combined with anti‐SSB. SS patients need not be identified frequently for anti‐SSA and ‐SSB because of their stability.
Source: Journal of Clinical Laboratory Analysis - November 9, 2012 Category: Laboratory Medicine Authors: Zaixing Yang, Yan Liang, Renqian Zhong Tags: Research Article Source Type: research

Gene expression profiling of macrophages: implications for an immunosuppressive effect of dissolucytotic gold ions
Conclusion: The data obtained in this study offer new insights into the mode of action of gold ions and suggest for the investigation of effects on other key cells and a possible future role of metallic gold as implants in rheumatoid arthritis or other inflammatory conditions.
Source: Journal of Inflammation - November 9, 2012 Category: Drugs & Pharmacology Authors: Oliver SeifertAndreas MatussekFlorence SjögrenRobert GeffersChris Anderson Source Type: research

Epigenetic contributions in the development of rheumatoid arthritis
Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints with severe pain and swelling, joint damage and disability, which leads to joint destruction and loss of function. Despite extensive research efforts, the underlying cause for RA is still unknown and current therapies are more or less effective in controlling symptoms, but still fail to cure the disease. In recent years, epigenetic modifications turned out to strongly contribute to the development of RA by affecting diverse aspects of the disease and modifying gene expression levels and behavior of several cell types, mo...
Source: Arthritis Research and Therapy - November 9, 2012 Category: Rheumatology Authors: Kerstin KleinCaroline OspeltSteffen Gay Source Type: research

CT scan evaluation of glenoid component fixation: a prospective study of 27 minimally cemented shoulder arthroplasties
Discussion/conclusion Long-term result of arthroplasty is correlated with glenoid durable fixation to underlying bone: this study shows higher fixation of glenoid component with bone integration of central peg. However, these results will have to be confirmed in a later revision. Content Type Journal ArticleCategory Original ArticlePages 1-5DOI 10.1007/s00590-012-1126-5Authors A. Vidil, Hôpital Saint Joseph, 185, rue Raymond Losserand, 75014 Paris, FrancePh. Valenti, Clinique Jouvenet 6, Square Jouvenet, 75016 Paris, FranceF. Guichoux, Hôpital Saint Joseph, 185, rue Raymond Losserand, 75014 Paris, ...
Source: European Journal of Orthopaedic Surgery and Traumatology - November 8, 2012 Category: Orthopaedics Tags: European Journal of Orthopaedic Surgery & Traumatology Source Type: research

Evaluation of the efficacy and safety of etanercept 50 mg once weekly in Japanese patients with rheumatoid arthritis and comparison with 25 mg etanercept twice weekly
Conclusion These results suggest that ETN50 can lead to earlier remission and higher remission rates compared with ETN25 in patients with RA. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s10165-012-0790-yAuthors Takeshi Mochizuki, Department of Orthopaedic Surgery, Kamagaya General Hospital, 929-6 Hatsutomi, Kamagaya, Chiba 273-0121, JapanShigeki Momohara, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, JapanKoichio Yano, Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, JapanToshikatsu Shirahata, Department of Orthopaedic Surgery...
Source: Modern Rheumatology - November 8, 2012 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Three cases of IgG4-related orbital inflammation presented as unilateral pseudotumor and review of the literature
We report here three cases of IgG4-related orbital inflammation that presented as unilateral pseudotumors. The patients all were men, with an age range of 65–75 years. The patients had been pointed out unilateral intra-orbital masses, and histopathological examinations revealed marked accumulation of IgG4-positive plasma cells (IgG4/IgG ratio: 51.1–71.6 %) with fibrosis. But storiform fibrosis was seen in only one case, and no obliterative phlebitis was seen. The serum levels of IgG4 were increased to 178–670 mg/dL. The masses had well-defined homogeneous signal intensities, and they were hypo-int...
Source: Rheumatology International - November 8, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

The accuracy of methods for urate crystal detection in synovial fluid and the effect of sample handling: A systematic review
This study aims to compare different methods of monosodium urate crystal (MSU) detection in synovial fluid (SF) and the effect of sample storage and handling on crystal detection. A systematic literature search was performed in MEDLINE, EMBASE, the Cochrane Library and the American College of Rheumatology/European League Against Rheumatism conference abstracts of 2010 and 2011. Studies that compared a method for detecting MSU crystals in SF with polarised light microscopy (PLM) or compared various SF storage and handling factors with the detection of MSU crystals as an outcome were included. Twelve studies out of 247 ...
Source: Clinical Rheumatology - November 8, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

The effect of dry needling in the treatment of myofascial pain syndrome: a randomized double-blinded placebo-controlled trial
The objective of this study was to test the hypothesis that dry needling is more effective than sham dry needling in the treatment of myofascial pain syndrome (MPS). This was a prospective, double-blinded, randomized-controlled study conducted in an outpatient clinic. Thirty-nine subjects with established myofascial trigger points were randomized into two groups: study group (N = 22) and placebo group (N = 17). Dry needling was applied using acupuncture needles, and sham dry needling was applied in the placebo group. The treatment was composed of six sessions which were performed in 4 weeks; the first four ...
Source: Clinical Rheumatology - November 8, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

Nodular progression of lentigo malignant melanoma during a treatment with tocilizumab: cause or coincidence?
We describe here the case of a patient with severe RA, previously treated with prednisolone, methotrexate, leflunomide, etanercept, and rituximab, who, after 8 months of treatment with tocilizumab, developed rapidly progressive nodular melanoma on a preexisting pigmented lesion on her left cheek. Recently, another case of nodular melanoma under tocilizumab has been published. The possible causative role of tocilizumab and other immunomodulatory agents in the development of this malignancy is discussed. Based on the present case, dermatologic screening is recommended before initiation of tocilizumab. Content ...
Source: Clinical Rheumatology - November 8, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

Midterm outcome of risedronate therapy for patients with Paget’s disease of bone in the central part of Japan
Abstract Although Paget’s disease of bone (PDB) is common in western countries, it is extremely rare in Asian ones including Japan. Recently, oral risedronate (17.5 mg once daily) was approved in Japan as a treatment of PDB besides calcitonin and etidronate. However, there are few data regarding the efficacy of this agent, dose for patients with PDB in Japan, or the durability of its effect. The purpose of this study was to evaluate the midterm outcome of oral risedronate (17.5 mg once daily) for patients with PDB in Japan. Seventeen patients with PDB were treated with risedronate (17.5 mg o...
Source: Clinical Rheumatology - November 8, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research

Fungal Disease of the Nose and Sinuses: An Updated Overview
Abstract Fungal diseases of the nose and sinuses encompasses a diverse spectrum of disease. Clinical manifestations are largely dependent upon the immune status of the host, as, given the ubiquitous nature of these organisms, exposure is unavoidable. Asymptomatic colonization of the nasal passages by fungi warrants no treatment and is common, while allergic fungal rhinosinusitis is challenging and often requires a combined approach of surgical intervention, immunotherapy, and corticosteroid administration. A diagnosis requires a combination of IgE immune reactivity, eosinophilic infiltration, and fungi recov...
Source: Current Allergy and Asthma Reports - November 8, 2012 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: research

Recurrent mitral valve regurgitation with neutrophil infiltration in a patient with multiple aseptic abscesses
We report a case of multiple abscesses in the subcutaneous tissues and joints, and severe mitral valve regurgitation. Although AA did not respond to antibiotic therapy, it improved dramatically with corticosteroid treatment. However, repeated valvuloplasty was required for the mitral valve regurgitation. The mitral valve tissue showed neutrophil infiltration without any bacterial invasion. This is the first case of AA to show involvement of cardiac valves, indicating the importance of systematic examination for patients with AA and cardiac valve involvement. Content Type Journal ArticleCategory Case ReportPages 1-...
Source: Modern Rheumatology - November 8, 2012 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Chondrocytes extract from patients with osteoarthritis induces chondrogenesis in infrapatellar fat pad-derived stem cells
Conclusions: We demonstrate for the first time that extracts obtained from chondrocytes of osteoarthritic knees promote chondrogenic differentiation of autologous IFPSCs. Moreover, combination of transdifferentiated IFPSCs with biodegradable PLGA 3D scaffolds can serve as an efficient system for the maintenance and maturation of cartilage tissue. These findings suggest its usefulness to repair articular surface in OA.
Source: Osteoarthritis and Cartilage - November 8, 2012 Category: Rheumatology Authors: E. López-Ruiz, M. Perán, J. Cobo-Molinos, G. Jiménez, M. Picón, M. Bustamante, F. Arrebola, M.C. Hernández-Lamas, A.D. Delgado-Martínez, E. Montañez, J.A. Marchal Tags: Original Articles Source Type: research

A novel impaction technique to create experimental articular fractures in large animal joints
Summary: Objective: A novel impaction fracture insult technique, developed for modeling post-traumatic osteoarthritis in porcine hocks in vivo, was tested to determine the extent to which it could replicate the cell-level cartilage pathology in human clinical intra-articular fractures.Design: Eight fresh porcine hocks (whole-joint specimens with fully viable chondrocytes) were subjected to fracture insult. From the fractured distal tibial surfaces, osteoarticular fragments were immediately sampled and cultured in vitro for 48 h. These samples were analyzed for the distribution and progression of chondrocyte death, using...
Source: Osteoarthritis and Cartilage - November 8, 2012 Category: Rheumatology Authors: Y. Tochigi, P. Zhang, M.J. Rudert, T.E. Baer, J.A. Martin, S.L. Hillis, T.D. Brown Tags: Original Articles Source Type: research

Osteoarthritis-related fibrosis is associated with both elevated pyridinoline cross-link formation and lysyl hydroxylase 2b expression
Conclusions: Our data show that elevated LH2b expression is associated with the persistent nature of TGF-β-induced fibrosis. Also in experimental OA, LH2b expression as well as the number of hydroxypyridinoline cross-link were significantly upregulated. We propose that LH2b, and the subsequent increase in pyridinoline cross-links, is responsible for the persistent fibrosis in experimental OA.
Source: Osteoarthritis and Cartilage - November 8, 2012 Category: Rheumatology Authors: D.F.G. Remst, E.N. Blaney Davidson, E.L. Vitters, A.B. Blom, R. Stoop, J.M. Snabel, R.A. Bank, W.B. van den Berg, P.M. van der Kraan Tags: Original Articles Source Type: research

Frequency and spatial distribution of cartilage thickness change in knee osteoarthritis and its relation to clinical and radiographic covariates – data from the osteoarthritis initiative
Conclusion: Most observed subregional changes in OA knees were indistinguishable from changes found in an asymptomatic cohort, but a fraction of subregions showed rapid progression. The relative frequency of rapid thinning increases when cKLG > 2, a classification closely associated with JSN and/or frequent knee pain are present.
Source: Osteoarthritis and Cartilage - November 8, 2012 Category: Rheumatology Authors: R.J. Buck, W. Wirth, D. Dreher, M. Nevitt, F. Eckstein Tags: Original Articles Source Type: research

Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation.
Abstract Phagocytes release inflammatory mediators to defense harmful stimuli upon bacterial invasion, however, excessive inflammatory reaction leads to tissue damage and manifestation of pathological states. Therefore, targeting on uncontrolled inflammation seems feasible to control numerous inflammation-associated diseases. Under the drug screening process of synthetic diphenylpyrazole derivatives, we discovered compound yuwen02f1 possesses anti-inflammatory effects in decreasing the release of pro-inflammatory cytokines including TNFα and IL-6, nitric oxide, reactive oxygen species (ROS) as well as inhibiting m...
Source: Biochemical Pharmacology - November 8, 2012 Category: Drugs & Pharmacology Authors: Hsu CC, Lien JC, Chang CW, Chang CH, Kuo SC, Huang TF Tags: Biochem Pharmacol Source Type: research

Antimicrobial susceptibility pattern of beta haemolytic Group A, C and G Streptococci isolated from North India.
This study suggests that variation in antibiotic resistance amongst BHS from North India is independent of source of isolation and emm type distribution, hence emphasizing the need for a longitudinal surveillance in different regions of India. PMID: 23139395 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - November 8, 2012 Category: Microbiology Authors: Dhanda V, Chaudhary P, Toor D, Kumar R, Chakraborti A Tags: J Med Microbiol Source Type: research

MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus.
Abstract Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles. The production of these cytokines is responsible for the mitogen-activated protein kinases (MAPKs), which can also generate mitogen-activated protein kinases phosphatases (MKPs). MKP-1, a prototypical member of the MKP family that can influence outcomes of autoimmune diseases and reduce the inflammatory cytokines by dephosphorylation of p38 and JNK MAPK, plays a criti...
Source: Lupus - November 8, 2012 Category: Rheumatology Authors: Yang J, Lu YW, Lu MM, Leng RX, Pan HF, Ye DQ Tags: Lupus Source Type: research

Familial Mediterranean fever in Germany: clinical presentation and amyloidosis risk.
Conclusions: Clinical symptoms of FMF-affected migrants living in Germany resemble those observed in their home country. In particular, patients with an onset of FMF symptoms after age 20 and a later FMF diagnosis have a high risk of AA amyloidosis. Symptomatic patients who originate from countries with a higher FMF prevalence should be screened for FMF and proteinuria. PMID: 23137073 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - November 8, 2012 Category: Rheumatology Authors: Ebrahimi-Fakhari D, Schönland S, Hegenbart U, Lohse P, Beimler J, Wahlster L, Ho A, Lorenz HM, Blank N Tags: Scand J Rheumatol Source Type: research

A Parallel Design Study to Assess the Bioequivalence of Generic and Branded Hydroxychloroquine Sulfate Tablets in Healthy Volunteers.
Abstract Hydroxychloroquine (HCQ) is a racemic 4-aminoquinoline derivative that was first introduced as an antimalarial, and subsequently applied to the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Information on the pharmacokinetics of HCQ in healthy volunteers, especially in a Chinese population is limited, and this study was conducted to provide support for a generic product to obtain marketing authorization in China.The aim of the present study was to compare the pharmacokinetics and assess bioequivalence of a new generic test and the branded reference hydroxyc...
Source: Arzneimittel-Forschung - November 8, 2012 Category: Drugs & Pharmacology Authors: Liu YM, Chen Q, Zhang MQ, Liu GY, Jia JY, Pu HH, Liu Y, Hu CY, Lu C, Wang W, Cao WE, Song B, Song YX, Zhu JM, Yu C Tags: Arzneimittelforschung Source Type: research

Informed Conditioning on Clinical Covariates Increases Power in Case-Control Association Studies
by Noah Zaitlen, Sara Lindström, Bogdan Pasaniuc, Marilyn Cornelis, Giulio Genovese, Samuela Pollack, Anne Barton, Heike Bickeböller, Donald W. Bowden, Steve Eyre, Barry I. Freedman, David J. Friedman, John K. Field, Leif Groop, Aage Haugen, Joachim Heinrich, Brian E. Henderson, Pamela J. Hicks, Lynne J. Hocking, Laurence N. Kolonel, Maria Teresa Landi, Carl D. Langefeld, Loic Le Marchand, Michael Meister, Ann W. Morgan, Olaide Y. Raji, Angela Risch, Albert Rosenberger, David Scherf, Sophia Steer, Martin Walshaw, Kevin M. Waters, Anthony G. Wilson, Paul Wordsworth, Shanbeh Zienolddiny, Eric Tchetgen Tchetgen, Christopher...
Source: PLoS Genetics - November 8, 2012 Category: Genetics & Stem Cells Authors: Noah Zaitlen et al. Source Type: research

An analysis of metabolic syndrome in adult dermatomyositis with a focus on cardiovascular disease
Conclusions.MetS is highly prevalent in DM, and prior hypertension seems to be a major determinant of its development while disease‐ and therapy‐related factors do not appear to play a relevant role. © 2012 by the American College of Rheumatology
Source: Arthritis Care and Research - November 8, 2012 Category: Rheumatology Authors: Mariana Teichner de Moraes, Fernando Henrique Carlos de Souza, Thiago Bitar Moraes de Barros, Samuel Katsuyuki Shinjo Tags: Original Article Source Type: research

Can knee arthroplasty play a role in weight management in knee osteoarthritis?
Source: Arthritis Care and Research - November 8, 2012 Category: Rheumatology Authors: Patricia D. Franklin, Milagros C. Rosal Tags: Editorial Source Type: research

Increased risk of arthropathies and joint replacement surgery in patients with genetic hemochromatosis
Conclusions: Patients with GH, but not their FDRs, are at increased risk for arthropathies, including the need for joint replacement surgery. © 2012 by the American College of Rheumatology
Source: Arthritis Care and Research - November 8, 2012 Category: Rheumatology Authors: Maria Elmberg, Rolf Hultcrantz, Julia F Simard, Åke Carlsson, Johan Askling Tags: Original Article Source Type: research

The risk of non‐hodgkin lymphoma in primary sjögren's syndrome, a population‐based study
Conclusion:The risk of NHL in patients with pSS in Norway is 9‐times increased compared with the general population. This is in accordance with recent studies, and the quality and completeness of the registries and strict use of diagnostic criteria support the validity of the results. © 2012 by the American College of Rheumatology
Source: Arthritis Care and Research - November 8, 2012 Category: Rheumatology Authors: Svein J. Johnsen, Johan G. Brun, Lasse G. Gøransson, Milada C. Småstuen, Tom B. Johannesen, Karstein Haldorsen, Erna Harboe, Roland Jonsson, Peter A. Meyer, Roald Omdal Tags: Brief Report Source Type: research