Rheumatology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 29.

Chronic inflammation and low-dose glucocorticoid effects on glucose metabolism in premenopausal females with rheumatoid arthritis free of conventional metabolic risk factors.
In conclusions, low-dose glucocorticoid treatment does not lead to glucose metabolism impairment in RA patients without other metabolic risk factors. Increased cardiovascular mortality and morbidity is probably due to a direct effect of systemic inflammation on myocardium and/or blood vessels. PMID: 23173679 [PubMed - as supplied by publisher]
Source: Physiological Research - November 22, 2012 Category: Physiology Authors: Penesova A, Radikova Z, Vlcek M, Kerlik J, Lukac J, Rovensky J, Imrich R Tags: Physiol Res Source Type: research

The Osteoarthritis Initiative (OAI) magnetic resonance imaging quality assurance update
We report 8years of quality assurance (QA) metrics for quantitative magnetic resonance (MR) knee analyses from the Osteoarthritis Initiative (OAI) and show the impact of MR system, phantom, and acquisition protocol changes.Method: Key 3T MR QA metrics, including signal-to-noise, signal uniformity, T2 relaxation times, and geometric distortion, were quantified monthly on two different phantoms using an automated program.Results: Over 8years, phantom measurements showed root-mean-square coefficient-of-variation reproducibility of
Source: Osteoarthritis and Cartilage - November 22, 2012 Category: Rheumatology Authors: E. Schneider, M. NessAiver Tags: Original Articles Source Type: research

Genetic support for the role of the NLRP3 inflammasome in psoriasis susceptibility
Abstract NACHT leucine‐rich repeat‐ and PYD‐containing (NLRP)3 protein controls the inflammasome by regulating caspase‐1 activity and interleukin (IL)‐1β processing. The contribution of IL‐1β in the pathogenesis of psoriasis is well recognized. Polymorphisms in NLRP3 and caspase recruitment domain–containing protein (CARD)8, a negative regulator of caspase‐1 activity, have been associated with susceptibility to common inflammatory diseases, such as Crohn's disease and rheumatoid arthritis. To investigate the role for genetic variants in the NLRP3 inflammasome in psoriasis susceptibility. In a patient samp...
Source: Experimental Dermatology - November 22, 2012 Category: Dermatology Authors: Maria Carlström, Anna‐Karin Ekman, Stina Petersson, Peter Söderkvist, Charlotta Enerbäck Tags: Original Article Source Type: research

The protein arginine deiminases: Structure, function, inhibition, and disease
Abstract The post‐translational modification of histones has significant effects on overall chromatin function. One such modification is citrullination, which is catalyzed by the protein arginine deiminases (PADs), a unique family of enzymes that catalyzes the hydrolysis of peptidyl‐arginine to form peptidyl‐citrulline on histones, fibrinogen, and other biologically relevant proteins. Overexpression and/or increased PAD activity is observed in several diseases, including rheumatoid arthritis, Alzheimer's disease, multiple sclerosis, lupus, Parkinson's disease, and cancer. This review discusses the important structura...
Source: Biopolymers - November 22, 2012 Category: Biochemistry Authors: Kevin L. Bicker, Paul R. Thompson Tags: Invited Review Source Type: research

Associations of the IL‐1F7 gene polymorphisms with rheumatoid arthritis in Chinese Han population
Summary Our aim was to investigate whether genetic polymorphism of IL‐1F7 (rs3811047) was involved in the susceptibility to rheumatoid arthritis (RA) in Chinese Han population. Single nucleotide polymorphism (SNP) of IL‐1F7 gene (rs3811047) was analyzed in 184 unrelated Chinese Han patients with RA and 184 healthy controls by ligase detection reaction based on high temperature ligase detection reactions polymerase chain reaction (LDR‐PCR). There were no statistically significant differences in the genetic polymorphism (genotypes and allele frequencies) of IL‐1F7 (rs3811047) in the patients with RA compared with con...
Source: International Journal of Immunogenetics - November 21, 2012 Category: Genetics & Stem Cells Authors: B. Pei, S. Xu, T. Liu, F. Pan, J. Xu, C. Ding Tags: Original Article Source Type: research

Neurologic consequence of a parvovirus B19 infection
We present the case of a patient with Guillain–Barre syndrome (GBS) associated with PVB 19.
Source: Journal of Clinical Virology - November 21, 2012 Category: Virology Authors: Gabriella Terhes, Márta Jenei, Edit Bereg, Sándor Túri, Judit Deák Tags: Full length articles Source Type: research

Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn medial meniscal tears
Conclusions: PHMM tears are associated with differences in underlying trabecular bone and deep layer of cartilage. Over-load of subchondral bone can lead to its sclerosis and stress shielding of trabecular bone leading to the resorptive changes observed in this study. The results underline the importance of interactions of trabecular bone and cartilage in the pathogenesis of knee OA in people with PHMM tears.
Source: Osteoarthritis and Cartilage - November 21, 2012 Category: Rheumatology Authors: D. Kumar, J. Schooler, J. Zuo, C.E. McCulloch, L. Nardo, T.M. Link, X. Li, S. Majumdar Tags: Original Articles Source Type: research

A performance based patient outcome score for active patients following total knee arthroplasty
Summary: Objective: The aim of this study was to develop and validate a user friendly performance based knee outcome score for use in active patients undergoing TKA surgery.Design: We prospectively studied a cohort of 50 subjects without any knee symptoms, and 50 patients who underwent TKA for osteoarthritis (OA). The patients were assessed pre- and postoperatively. SF-36 and WOMAC were concurrently administered for comparison. Patients completed seven physical tasks of the finalised outcome instrument which were objectively assessed and scored.Results: The mean functional score was 31.7 in the normal subjects. The mean fu...
Source: Osteoarthritis and Cartilage - November 21, 2012 Category: Rheumatology Authors: F.S. Hossain, S. Patel, M.A. Fernandez, S. Konan, F.S. Haddad Tags: Original Articles Source Type: research

Graves′ hyperthyroidism and moderate alcohol consumption: evidence for disease prevention
ConclusionsModerate alcohol consumption is associated with a considerable reduction in the risk of Graves′ disease with hyperthyroidism ‐ irrespective of age and sex. Autoimmune thyroid disease seems to be much more dependent on environmental factors than hitherto anticipated.© 2012 Blackwell Publishing Ltd
Source: Clinical Endocrinology - November 21, 2012 Category: Endocrinology Authors: Allan Carlé, Inge Bülow Pedersen, Nils Knudsen, Hans Perrild, Lars Ovesen, Lone Banke Rasmussen, Torben Jørgensen, Peter Laurberg Tags: Original Article Source Type: research

DX5(+) CD4(+) T cells modulate CD4(+) T-cell response via inhibition of IL-12 production by dendritic cells.
DX5(+) CD4(+) T cells modulate CD4(+) T-cell response via inhibition of IL-12 production by dendritic cells. Eur J Immunol. 2012 Nov 21; Authors: El Bannoudi H, Han WG, Stoop JN, Louis-Plence P, Huizinga TW, Toes RE Abstract DX5(+) CD4(+) T cells have been shown to dampen collagen induced arthritis (CIA) and delayed type hypersensitivity reactions in mice. These cells are also potent modulators of T helper cell responses through direct effects on CD4(+) T cells in an IL-4 dependent manner. To further characterize this T-cell population we studied their effect on dendritic cells (DCs) and the potential conse...
Source: European Journal of Immunology - November 21, 2012 Category: Allergy & Immunology Authors: El Bannoudi H, Han WG, Stoop JN, Louis-Plence P, Huizinga TW, Toes RE Tags: Eur J Immunol Source Type: research

Gender Differences in Pain Severity, Disability, Depression, and Widespread Pressure Pain Sensitivity in Patients with Fibromyalgia Syndrome Without Comorbid Conditions
ConclusionsWomen with FMS showed higher pain severity and lower PPT than men, whereas men exhibited longer duration of symptoms and disability. In men with FMS, the intensity of ongoing pain was positively correlated to pressure hyperalgesia over the neck. This study suggests that FMS could show a different phenotype in women and men and confirm that women exhibit lower PPT than men.
Source: Pain Medicine - November 21, 2012 Category: Anesthesiology Authors: Adelaida M. Castro‐Sánchez, Guillermo A. Matarán‐Peñarrocha, María M. López‐Rodríguez, Inmaculada C. Lara‐Palomo, Lars Arendt‐Nielsen, César Fernández‐de‐las‐Peñas Tags: Original Article Source Type: research

Fibromyalgia Family and Relationship Impact Exploratory Survey
ConclusionsIn addition to physical impairments that are well documented among individuals with fibromyalgia, fibromyalgia can result in a substantial negative impact on important relationships with family and close friends. Copyright © 2012 John Wiley & Sons, Ltd.
Source: Musculoskeletal Care - November 21, 2012 Category: Physiotherapy Authors: Dawn A. Marcus, Karen Lee Richards, Janet F. Chambers, Amrita Bhowmick Tags: Research Article Source Type: research

Use of medical tourism for hip and knee surgery in osteoarthritis: A qualitative examination of distinctive attitudinal characteristics among Canadian patients
Conclusions: Compared to other patients reported on in the existing qualitative hip and knee surgery literature, medical tourists are less likely to question their need for surgery and are particularly active in their pursuit of surgical intervention. They are also comfortable with taking control of health-related decisions. Future research is needed to identify motivators behind patients' pursuit of care abroad, determine if the attitudinal characteristics identified here hold true for other patient groups, and ascertain the impact of these attitudinal characteristics on surgical outcomes. Arthritis care providers can use...
Source: BMC Health Services Research - November 21, 2012 Category: Journals (General) Authors: Valorie CrooksKeri CameronVera ChouinardRory JohnstonJeremy SnyderVictoria Casey Source Type: research

Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease
Conclusions: The resistin, S100A12 and sRAGE are involved in the pathophysiology of KD.
Source: Arthritis Research and Therapy - November 21, 2012 Category: Rheumatology Authors: Yanqi QiFangqi GongQing ZhangChunhong XieWei WangSongling Fu Source Type: research

APRIL, a proliferation-inducing ligand, as a potential marker of lupus nephritis
Conclusion: APRIL could be a potential biomarker for predicting difficult-to-treat cases of lupus nephritis.
Source: Arthritis Research and Therapy - November 21, 2012 Category: Rheumatology Authors: Worapot TreamtrakanponPornpen TantivitayakulThitima BenjachatPoorichaya SomparnWipawee KittikowitSomchai Eiam-ongAsada LeelahavanichkulNattiya HirankarnYingyos Avihingsanon Source Type: research

Minocycline-associated rimmed vacuolar myopathy in a patient with rheumatoid arthritis
Conclusions: This is the first report of minocycline-induced pigmentation in skeletal muscle. The strong association between autophagic vacuoles and the accumulation of minocycline-induced pigments suggest that long-term minocycline treatment induced pigment accumulation, leading to elevation of autophagic activity and RVM. It might also be possible that minocycline directly activated autophagy, as the observed pigments are known to form complexes containing minocycline and/or its metabolites. As long-term minocycline treatment is expected to be used more widely in the future, we must draw attention to this adverse effect.
Source: BMC Neurology - November 21, 2012 Category: Neurology Authors: Kota BokudaKeizo SugayaShunichiro TamuraKazuhito MiyamotoShiro MatsubaraTakashi Komori Source Type: research

DX5+CD4+ T cells modulate CD4+ T‐cell response via inhibition of IL‐12 production by dendritic cells
DX5+CD4+ T cells have been shown to dampen collagen induced arthritis (CIA) and delayed type hypersensitivity reactions in mice. These cells are also potent modulators of T helper cell responses through direct effects on CD4+ T cells in an IL‐4 dependent manner. To further characterize this T‐cell population we studied their effect on dendritic cells (DCs) and the potential consequences on T‐cell activation. Here we show that mouse DX5+CD4+ T cells modulate DCs by robustly inhibiting IL‐12 production. This modulation is IL‐10 dependent and does not require cell contact. Furthermore DX5+CD4+ T cells modulate the s...
Source: European Journal of Immunology - November 21, 2012 Category: Allergy & Immunology Authors: Hanane el Bannoudi, Wanda G. H. Han, Jeroen. N. Stoop, Pascale Louis‐Plence, Tom W. J. Huizinga, René E. M. Toes Tags: Regular Article Source Type: research

Epigenetic changes in inflammatory and autoimmune diseases.
Abstract In higher eukaryotic organisms epigenetic modifications are crucial for proper chromatin folding and thereby proper regulation of gene expression. In the last years the involvement of aberrant epigenetic modifications in inflammatory and autoimmune diseases has been recognized and attracted significant interest. However, the epigenetic mechanisms underlying the different disease phenotypes are still poorly understood. As autoimmune and inflammatory diseases are at least partly T cell mediated, we will provide in this chapter an introduction to the epigenetics of T cell differentiation followed by a summary...
Source: Sub-Cellular Biochemistry - November 20, 2012 Category: Biochemistry Authors: Nielsen HM, Tost J Tags: Subcell Biochem Source Type: research

Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages.
In this study, we investigated the effects of ATA on the alternative complement pathway. We found that ATA prevented cleavage of the tissue bound properdin-C3b-Factor B complex into the active C3 convertase enzyme properdin-C3b-Factor Bb. This inhibition was reversed by adding Factor D to the serum. Using enzyme-linked immunosorbent type assays, we established that ATA binds directly to Factor D and C9 but not to properdin or other complement proteins. We conclude that ATA, by inhibiting at two stages of the alternative pathway, might be a particularly effective therapeutic agent in conditions such as macular degeneration,...
Source: Neurobiology of Aging - November 20, 2012 Category: Geriatrics Authors: Lee M, Guo JP, McGeer EG, McGeer PL Tags: Neurobiol Aging Source Type: research

Prevalence and predictors of Sjogren's syndrome in a prospective cohort of patients with aqueous-deficient dry eye
Conclusions Ophthalmologists caring for patients with clinically significant dry eye should have a high index of suspicion for underlying SS and low threshold for serological work-up. RF and ANA are recommended as useful tests in SSA/SSB-negative patients for further diagnostic referral.
Source: British Journal of Ophthalmology - November 20, 2012 Category: Opthalmology Authors: Liew, M., Zhang, M., Kim, E., Akpek, E. K. Tags: Epidemiology Original articles - Clinical science Source Type: research

Anti‐citrullinated glucose‐6‐phosphate isomerase peptide antibodies in patients with rheumatoid arthritis are associated with HLA‐DRB1 shared epitope alleles and disease activity
ConclusionThis is the first report documenting the presence of anti‐CCG Abs in RA. Anti‐CCG‐2 and ‐7 Abs could be considered as markers for the diagnosis of RA and its disease activity.
Source: Clinical and Experimental Immunology - November 20, 2012 Category: Allergy & Immunology Authors: Naoto Umeda, Isao Matsumoto, Ikue Ito, Aya Kawasaki, Yoko Tanaka, Asuka Inoue, Yuki Tanaka, Hiroto Tsuboi, Takeshi Suzuki, Taichi Hayashi, Satoshi Ito, Naoyuki Tsuchiya, Takayuki Sumida Tags: Original Article Source Type: research

Sonographic Evaluation of Subclinical Entheseal Involvement in Patients With Behcet Disease
CONCLUSION. This is the first study to our knowledge to show significant subclinical enthesopathy of the triceps tendon enthesis in patients with Behçet disease who had no arthritic involvement. These data suggest that the Madrid sonography enthesitis index scoring system for sonographic detection of enthesopathy should be incorporated into the clinical protocol for evaluating patients with Behçet disease in routine clinical practice.
Source: American Journal of Roentgenology - November 20, 2012 Category: Radiology Authors: Ozkan, F., Cetin, G. Y., Bakan, B., Kalender, A. M., Yuksel, M., Ekerbicer, H. C., Sayarlioglu, M. Tags: Musculoskeletal Imaging Source Type: research

Cyclophilin A secreted from fibroblast-like synoviocytes is involved in the induction of CD147 expression in macrophages of mice with collagen-induced arthritis
Conclusions: These findings suggest that an interaction in the synovial joints between extracellular CypA and CD147 expressed by macrophages may be involved in the mechanisms underlying the development of arthritis.
Source: Journal of Inflammation - November 20, 2012 Category: Drugs & Pharmacology Authors: Tsuyoshi NishiokuShinya DohguMitsuhisa KogaTakashi MachidaTakuya WatanabeTeppei MiuraKousuke TsumagariMariko TerasawaAtsushi YamauchiYasufumi Kataoka Source Type: research

Internet-based cognitive behavioural therapy (FITNET) is an effective treatment for adolescents with chronic fatigue syndrome
Study design Design: Randomised controlled trial. Allocation: Computer generated blocked allocation. Blinding: Investigators and participants were not blinded. Study question Setting: Two outpatient clinics in Holland (paediatric hospital and treatment coordinating centre) receiving nationwide referrals. Patients: 135 adolescents aged 12–18 years with chronic fatigue symptoms (Centers for Disease Control and prevention (CDC) definition). Intervention: Adolescents were randomised to two groups to receive: newly developed computer-based FITNET programme (containing cognitive behavioural modules, e-consults and a separa...
Source: Archives of Disease in Childhood - Education and Practice - November 20, 2012 Category: Pediatrics Authors: Crawley, E. M. Tags: Clinical trials (epidemiology), Drugs: CNS (not psychiatric), Infection (neurology), Neuromuscular disease, Adolescent health, Child and adolescent psychiatry (paedatrics), Child health, Rheumatology Structured abstracts of sentinel articles: Picket Source Type: research

An overview of drug therapies used in the treatment of dystonia and spasticity in children
Introduction Spasticity is defined clinically as ‘a motor disorder characterised by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon acts resulting from hyperexcitability of the stretch reflex, as one component of the upper motor neuron syndrome’.1 Spasticity is a common feature of cerebral palsy (CP) as well as spinal cord and traumatic brain injury. The most common cause of spasticity in childhood is CP which affects between 2 and 3 of every 1000 live births in industrialised countries.2 Other causes of spasticity include traumatic brain injury, spinal cord injury,...
Source: Archives of Disease in Childhood - Education and Practice - November 20, 2012 Category: Pediatrics Authors: Tickner, N., Apps, J. R., Keady, S., Sutcliffe, A. G. Tags: Eye Diseases, Cerebral palsy, Other rehabilitative therapies, Drugs: CNS (not psychiatric), Hydrocephalus, Neurological injury, Ophthalmology, Child health, Physiotherapy, Rheumatology, Dentistry and oral medicine, Physiotherapy, Trauma, Metabolic disorde Source Type: research

Effect of Bizhongxiao decoction and its dismantled formulae on IL-1 and TNF levels in collagen-induced arthritis in rat synovial joints
Background: Rheumatoid arthritis (RA), a chronic autoimmune disease, affects sufferers in many different ways. Treatment of this chronic condition is particularly challenging. Traditional Chinese Medicine (TCM) provides alternatives. Bizhongxiao decoction (BZX) is a TCM complex, which has been used clinically for many years to treat RA. The purpose of this study is to compare the effects of BZX decoction and its dismantled formulae on IL-1 and TNF-1 levels in rats with RA, and to elucidate its mechanism of action. Methods: Ninety healthy normal female SD rats were randomly divided into six groups: normal (control), model, ...
Source: Theoretical Biology and Medical Modelling - November 20, 2012 Category: Biomedical Science Authors: Guo Ya-jingChen JiangXiong Xin-guiWu DanZhu HaoLiang Qing-hua Source Type: research

Seeking insights into the EPidemiology, treatment and Outcome of Childhood Arthritis through a multinational collaborative effort: Introduction of the EPOCA study
The epidemiology of juvenile idiopathic arthritis (JIA) is variable worldwide. In particular, a wide disparity exists in the prevalence of the diverse disease subtypes across different geographic areas. The therapeutic approach to JIA is not standardized and no established and widely accepted guidelines are available. In the past decade, there have been important progresses in the management of the disease, but the availability of the novel and costly biologic medications is not uniform throughout the world. This issue may have significant impact on disease prognosis, with children living in poorer countries being at great...
Source: Pediatric Rheumatology - November 20, 2012 Category: Rheumatology Authors: Alessandro ConsolaroNicolino RupertoGiovanni FilocamoStefano LanniGiulia BraccioliniMarco GarroneSilvia ScalaLuca VillaGiuseppe SilvestriDaniela TaniAlessandra ZolesiAlberto MartiniAngelo Ravelli Source Type: research

Long-term results of Latarjet procedure for the treatment of anterior glenohumeral instability: a 20-year follow-up study
The purpose of this study was to evaluate the long-term results of the Latarjet procedure and to determine the prevalence and risk factors of glenohumeral arthritis. Three hundred thirty-four Latarjet procedures were performed between 1988 and 1993 for the treatment of anterior glenohumeral instability. A retrospective review was available for 59 patients (65 shoulders). Mean age at surgery was 29.6 years of age. The mean follow-up period was 20 years. All patients had a clinical and radiographic evaluation preoperatively and postoperatively. Clinical results were evaluated with Rowe score and Subjective Shoulder Value (S...
Source: Journal of Shoulder and Elbow Surgery - November 19, 2012 Category: Orthopaedics Authors: Naoko Mizuno, Gilles Walch Tags: Abstracts from the 2012 Japan Shoulder Society Meeting Source Type: research

Surgical Treatment of the Arthritic Varus Ankle
Within the past several years, the arthritic varus ankle has been addressed extensively in Foot and Ankle Clinics, with numerous excellent reviews by particularly knowledgeable authors. To support these outstanding contributions, this article provides a practical approach to this challenging constellation of foot and ankle abnormalities. Varus ankle arthritis exists on a continuum that prompts the treating surgeon to be familiar with a spectrum of surgical solutions, including joint-sparing realignment, arthroplasty, and arthrodesis. Each of these treatment options is addressed with several expanded case examples and suppo...
Source: Foot and Ankle Clinics - November 19, 2012 Category: Orthopaedics Authors: Mark E. Easley Source Type: research

Wrist Arthroplasty: Partial and Total
This article provides a review of the history, indications, techniques, and outcomes of wrist arthroplasty.
Source: Hand Clinics - November 19, 2012 Category: Orthopaedics Authors: Brian D. Adams Source Type: research

Trapezium Prosthetic Arthroplasty (Silicone, Artelon, Metal, and Pyrocarbon)
Trapezium prosthetic arthroplasty has been utilized to treat basal joint arthritis for nearly five decades in an attempt to mitigate some of the potential disadvantages of trapeziectomy while preserving range of motion. Implant arthroplasty seeks to preserve joint biomechanics, avoids metacarpal subsidence, and should provide immediate stability. These benefits may lead to improvements in strength, durability, and a decrease in metacarpophalangeal joint hyperextension which can occur subsequent to metacarpal shortening. First generation implants were primarily silicone trapezial spacers. While the use of these implants has...
Source: Hand Clinics - November 19, 2012 Category: Orthopaedics Authors: Mark A. Vitale, Fraser Taylor, Mark Ross, Steven L. Moran Source Type: research

Ligament Reconstruction and Tendon Interposition for Thumb Basal Arthritis
This article summarizes the history, method, and expected results of basal joint arthroplasty, and the authors describe their method of ligament reconstruction and tendon interposition for thumb basal arthritis.
Source: Hand Clinics - November 19, 2012 Category: Orthopaedics Authors: John C. Elfar, Richard I. Burton Source Type: research

The role of hyaluronan in aortic stiffening in patients with rheumatoid arthritis
Introduction: Patients with rheumatoid arthritis (RA) have increased aortic stiffness, which can be improved with anti-inflammatory therapies. However, how inflammation leads to aortic stiffening remains unclear. One potential mechanism is by overproduction of hyaluronan (HA) in the extracellular matrix, which results in stiffening of the arterial wall by thinning of elastic lamellae in animal models. However, the effect in man is unknown. The aim was to evaluate 1) whether serum HA concentration is a valid surrogate of aortic tissue level and 2) to compare serum HA in patients with RA and control subjects and to relate th...
Source: Artery Research - November 19, 2012 Category: Cardiology Authors: K.M. Maki-Petaja, R. Patel, S.E. Cleary, M. Yasmin, I.B. Wilkinson Tags: Abstracts from Artery 12, Tech Gate, Vienna, Austria, 18–20 October 2012 Source Type: research

Agility to INBONE: Anterior and Posterior Approaches to the Difficult Revision Total Ankle Replacement
This report is unique in that anterior and posterior approaches are discussed and detailed. Although the authors present successful conversion of the Agility total ankle replacement to an INBONE total ankle replacement, the difficulty of this procedure is demonstrated by the high complication rate and 2 early failures.
Source: Clinics in Podiatric Medicine and Surgery - November 19, 2012 Category: Podiatry Authors: J. George DeVries, Ryan T. Scott, Gregory C. Berlet, Christopher F. Hyer, Thomas H. Lee, James K. DeOrio Source Type: research

WT1 peptide immunotherapy for gynecologic malignancies resistant to conventional therapies: a phase II trial
Conclusion WT1 peptide vaccine may be a potential treatment, with limited toxicity, for gynecologic malignancies that have become resistant to conventional therapies. Larger scale of clinical studies is required to establish the efficacy of the WT1 peptide vaccine for gynecologic malignancies. Content Type Journal ArticleCategory Original PaperPages 1-7DOI 10.1007/s00432-012-1348-2Authors Takashi Miyatake, Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871 JapanYutaka Ueda, Department of Obstetrics and Gynecology, Osaka Unive...
Source: Journal of Cancer Research and Clinical Oncology - November 19, 2012 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: research

Kikuchi-Fujimoto disease: a case supporting a role for human herpesvirus 7 involvement in the pathogenesis
We report the case of a 24-year-old Caucasian female patient with cervical lymphadenopathy and isolated pruriginous maculo-papular lesions who was diagnosed of Kikuchi’s disease in whom the presence of human herpesvirus 7 DNA was documented in the affected lymph node specimen in the absent of other viruses. Therefore, a possible etiologic relation between the Kikuchi’s disease of this patient and human herpesvirus 7 was established, supporting a role for human herpesvirus 7 involvement in the pathogenesis. Content Type Journal ArticleCategory Short CommunicationPages 1-4DOI 10.1007/s00296-012-2562-6Authors J...
Source: Rheumatology International - November 19, 2012 Category: Rheumatology Tags: Rheumatology International Source Type: research

Erratum to: Phase II dose–response study of abatacept in Japanese patients with active rheumatoid arthritis with an inadequate response to methotrexate
Content Type Journal ArticleCategory ErratumPages 1-1DOI 10.1007/s10165-012-0798-3Authors Tsutomu Takeuchi, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582 JapanTsukasa Matsubara, Department of Orthopedics, Matsubara Mayflower Hospital, 944-25 Fujita, Kato, Hyogo 673-1462, JapanTaisuke Nitobe, Department of Orthopedics, Seihoku Chuoh Hospital, 41 Nunoyacho, Goshogawara, Aomori 037-0053, JapanEiichi Suematsu, Department of Internal Medicine and Rheumatology, National Hospital Organization Kyushu Medical Center, 1-8-1 Jigyohama,...
Source: Modern Rheumatology - November 19, 2012 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Subclinical cardiovascular target organ damage manifestations of ankylosing spondylitis in young adult patients
Conclusion Myocardial diastolic functions were significantly deteriorated in the AS patients, and disease activity and myocardial diastolic functions were associated. An interesting finding was that patients receiving anti-TNF-α had better aortic elasticity than those treated with NSAIDs. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s10165-012-0791-xAuthors Suleyman Ercan, Department of Cardiology, School of Medicine, Gaziantep University, 27310 Gaziantep, TurkeyFatih Goktepe, Department of Rheumatology, School of Medicine, Gaziantep University, Gaziantep, TurkeyBunyami...
Source: Modern Rheumatology - November 19, 2012 Category: Rheumatology Tags: Modern Rheumatology Source Type: research

Transscleral diode laser cyclophotocoagulation for refractory glaucoma secondary to juvenile idiopathic arthritis: a short term follow-up
Abstract To evaluate the success rates of transscleral diode cyclophotocoagulation (TD-CPC) for refractory secondary glaucoma in a paediatric patient with juvenile idiopathic arthritis. Report of a case of a 6-year-old boy suffering from severe uveitis, and secondary open angle glaucoma. The patient had undergone bilateral cataract surgery, two prior trabeculectomies in the left and one in the right eye. He was under systemic immunomodulation with methotrexate and cyclosporine. He presented with medically uncontrolled glaucoma, with an intraocular pressure (IOP) of 36 and 34 mmHg in the right and left e...
Source: International Ophthalmology - November 19, 2012 Category: Opthalmology Tags: International Ophthalmology Source Type: research

HLA-dependent autoantibodies against post-translationally modified collagen type II in type 1 diabetes mellitus
Conclusion Hyperglycaemia and oxidative stress may trigger genetically controlled autoimmunity to ROS-CII and may explain the association between type 1 diabetes mellitus and RA. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-012-2780-1Authors R. Strollo, Bone and Joint Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, Charterhouse Square, London, EC1M 6BQ UKP. Rizzo, Bone and Joint Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Q...
Source: Diabetologia - November 19, 2012 Category: Endocrinology Tags: Diabetologia Source Type: research

Mysterious neck pain
Sternoclavicular septic arthritis is an unusual condition that accounts for approximately 0.5% to 1% of all infectious arthritis and accounts only 23% in nonrisk factor, immunocompetent patients. In contrast to other septic arthritis, the presentation was likely to be more subacute presentation. Cardinal signs of infection were not present in most of the cases. A high index of suspicion is needed to establish a diagnosis because an insidious onset, false-negative physical findings, and inconclusive results from computed tomographic scan are common, as in this presented case. Familiarity with the diagnosis is paramount to p...
Source: The American Journal of Emergency Medicine - November 19, 2012 Category: Emergency Medicine Authors: Quanhathai Kaewpoowat, Kunatum Prasidthrathsint, Nitipong Permpalung, Promporn Suksaranjit, Edward Bischof Tags: Case Reports Source Type: research

Chronic Disease Management: A Review of Current Performance Across Quality of Care Domains and Opportunities for Improving Osteoarthritis Care
Osteoarthritis is the most prevalent chronic joint disease worldwide. The incidence and prevalence are increasing as the population ages and lifestyle risk factors such as obesity increase. There are several evidence-based clinical practice guidelines available to guide clinician decision making, but there is evidence that care provided is suboptimal across all domains of quality: effectiveness, safety, timeliness and appropriateness, patient-centered care, and efficiency. System, clinician, and patient barriers to optimizing care need to be addressed. Innovative models designed to meet patient needs and those that harness...
Source: Rheumatic Disease Clinics of North America - November 19, 2012 Category: Rheumatology Authors: Caroline A. Brand, Ilana N. Ackerman, Megan A. Bohensky, Kim L. Bennell Source Type: research

Erratum to “Osteoarthritis 2012 year in review: rehabilitation and outcomes” [Osteoarthritis and Cartilage 2012;20:1477–1483]
The publisher regrets that the incorrect Corresponding Author details were given for this article. The correct details are E.M. Roos, Research Unit for Musculoskeletal Function, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Source: Osteoarthritis and Cartilage - November 19, 2012 Category: Rheumatology Authors: E.M. Roos, C.B. Juhl Tags: Erratum Source Type: research

Microstructural analysis of collagen and elastin fibres in the kangaroo articular cartilage reveals a structural divergence depending on its local mechanical environment
Conclusions: The present study demonstrates that the collagen structure and texture of kangaroo articular cartilage is joint-dependent. This finding emphasizes the effects of loading on collagen development and suggests that articular cartilage with high biochemical and biomechanical qualities could be achieved by optimizing joint loading, which may benefit cartilage tissue engineering and prevention of joint injury. The existence of elastin fibres in articular cartilage could have important functional implications.
Source: Osteoarthritis and Cartilage - November 19, 2012 Category: Rheumatology Authors: B. He, J.P. Wu, S.M. Chim, J. Xu, T.B. Kirk Tags: Original Articles Source Type: research

Medial arch supports do not significantly alter the knee adduction moment in people with knee osteoarthritis
Conclusions: This study showed no mean change in any of the measured indices of medial knee load with medial arch supports. No immediate changes in knee pain were evident.
Source: Osteoarthritis and Cartilage - November 19, 2012 Category: Rheumatology Authors: R.S. Hinman, L. Bardin, M. Simic, K.L. Bennell Tags: Original Articles Source Type: research

Implementation of a quality care management system for patients with arthritis of the hip and knee.
PMID: 23159034 [PubMed - as supplied by publisher]
Source: Australian Health Review - November 19, 2012 Category: Hospital Management Authors: Doerr CR, Mercer GE, Osborne RH Tags: Aust Health Rev Source Type: research

Diagnostic delay for endometriosis in Austria and Germany: causes and possible consequences
STUDY QUESTION What is the length of the diagnostic delay for endometriosis in Austria and Germany, and what are the reasons for the delay? SUMMARY ANSWER The diagnostic delay for endometriosis in Austria and Germany is surprisingly long, due to both medical and psychosocial reasons. WHAT IS KNOWN ALREADY Diagnostic delay of endometriosis is a problematic phenomenon which has been evaluated in several European countries and in the USA, but has not been reported for Germany and Austria. STUDY DESIGN, SIZE, DURATION A cross-sectional, questionnaire-based multicentre study was conducted in tertiary referral centers in Aust...
Source: Human Reproduction - November 19, 2012 Category: Reproduction Medicine Authors: Hudelist, G., Fritzer, N., Thomas, A., Niehues, C., Oppelt, P., Haas, D., Tammaa, A., Salzer, H. Tags: Gynaecology Source Type: research

Ibuprofen: from invention to an OTC therapeutic mainstay
Summary The discovery of ibuprofen’s anti‐inflammatory activity by Dr (now Professor) Stewart Adams and colleagues (Boots Pure Chemical Company Ltd, Nottingham, UK) 50 years ago represented a milestone in the development of anti‐inflammatory analgesics. Subsequent clinical studies were the basis for ibuprofen being widely accepted for treating painful conditions at high anti‐rheumatic doses (≤ 2400 mg/d), with lower doses (≤ 1200 mg/d for ≤ 10 days) for mild–moderate acute pain (e.g. dental pain, headache, dysmenorrhoea, respiratory symptoms and acute injury). The early observations have since...
Source: International Journal of Clinical Practice - November 19, 2012 Category: Internal Medicine Authors: K. D. Rainsford Tags: REVIEW ARTICLE Source Type: research

Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells
Vol. 208, No. 1, January 17, 2011. Pages 103–114. The authors regret that the incorrect primer sequences were reported for mouse IL-6 and CCL20. The correct sequences are as follows (forward and reverse): IL-6, 5'-GAGGATACCACTCCCAACAGACC-3' and 5'-AAGTGCATCATCGTTGTTCATACA-3';...
Source: The Journal of Experimental Medicine - November 19, 2012 Category: Internal Medicine Authors: Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., Takatsu, K., Kamimura, D., Hirano, T. Tags: Corrections Source Type: research

Analysis of a wild mouse promoter variant reveals a novel role for Fc{gamma}RIIb in the control of the germinal center and autoimmunity
Genetic variants of the inhibitory Fc receptor FcRIIb have been associated with systemic lupus erythematosus in humans and mice. The mechanism by which Fcgr2b variants contribute to the development of autoimmunity is unknown and was investigated by knocking in the most commonly conserved wild mouse Fcgr2b promoter haplotype, also associated with autoimmune-prone mouse strains, into the C57BL/6 background. We found that in the absence of an AP-1–binding site in its promoter, FcRIIb failed to be up-regulated on activated and germinal center (GC) B cells. This resulted in enhanced GC responses, increased affinity matura...
Source: The Journal of Experimental Medicine - November 19, 2012 Category: Internal Medicine Authors: Espeli, M., Clatworthy, M. R., Bokers, S., Lawlor, K. E., Cutler, A. J., Kontgen, F., Lyons, P. A., Smith, K. G. C. Tags: Articles Source Type: research