Rheumatology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.
Have a look at The Rheumatology Daily, the new rheumatology portal powered by MedWorm, with all the latest rheumatology news and research updated daily.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 7.
Letter to the editor regarding: Zhang Y et al. Cherry consumption and the risk of recurrent gout attacks. Arthritis Rheum 2012; 64:4004‐11.
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Naomi Schlesinger, Michael Schlesinger Tags: Letter to the editor Source Type: research
Functionally relevant regulatory T cells are present in giant‐cell arteritis lesions. Comment on the paper by Samson et al
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Marc Corbera‐Bellalta, Ester Planas‐Rigol, Georgina Espígol‐Frigolé, Ester Lozano, Maria C Cid Tags: Letter to the editor Source Type: research
Hypoxia promotes production and inhibits destruction of human articular cartilage
Conclusion.Our data reveal that while fundamental regulators like SOX9 are key for both mouse and man, the way in which they are controlled can differ. This is all the more important since it is such upstream regulators that need to be directly targeted for therapeutic benefit. HIF‐targeting hydroxylase PHD2 may represent a relevant target for cartilage repair.
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Brendan L. Thoms, Katarzyna A. Dudek, Jérôme E. Lafont, Christopher L. Murphy Tags: Full Length Source Type: research
Matrix metalloproteinase‐13 expression in response to double‐stranded RNA in human chondrocytes
Conclusions:dsRNA‐signalling in chondrocytes requires a range of PRRs including TLR3, RIG‐I and MDA5 for the full‐induction of MMP13, thus providing tight regulation of a gene critical for maintenance of cartilage integrity. Our data add to the understanding of MMP13 regulation, which is essential before such mechanisms can be exploited to alleviate the cartilage destruction associated with OA.
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Marta Radwan, Christos Gavriilidis, John H Robinson, Rose Davidson, Ian M. Clark, Andrew D. Rowan, David A. Young Tags: Full Length Source Type: research
B cells identified according to their expression of CD19 and surface Ig are depleted from peripheral blood by rituximab in patients with RA
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Henrik E. Mei, Thomas Dörner Tags: Letter to the Editor Source Type: research
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Jonathan D. Jones, B. JoNell Hamilton, William F.C. Rigby Tags: Reply to Letter to the Editor Source Type: research
CD19 is a useful B‐cell marker after treatment with rituximab: Comment on the article by Jones et al
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Elena G. Kamburova, Hans J. M. P. Koenen, Irma Joosten, Luuk B. Hilbrands Tags: Letter to the Editor Source Type: research
PTPome profile of rheumatoid arthritis fibroblast‐like synoviocytes: a novel role for SHP‐2 as a modulator of invasion and survival
CONCLUSION:These findings indicate a novel role for SHP‐2 in mediating human FLS function, and suggest that SHP‐2 promotes the invasiveness and survival of RA FLS. Further investigation may reveal SHP‐2 to be a candidate therapeutic target for RA.
Source: Arthritis and Rheumatism - January 17, 2013 Category: Rheumatology Authors: Stephanie M. Stanford, Michael F. Maestre, Amanda M. Campbell, Beatrix Bartok, William B. Kiosses, David L. Boyle, Heather A. Arnett, Tomas Mustelin, Gary S. Firestein, Nunzio Bottini Tags: Full Length Source Type: research
Fracture after androgen deprivation therapy among men with a high baseline risk of skeletal complications
Conclusions Men with a high baseline risk of skeletal complications developed more fractures after ADT. The mortality risk is 40% higher after experiencing a fracture. Consideration of patient risk before prescribing ADT for long‐term use may reduce both fracture risk and fracture‐associated mortality.
Source: BJU International - January 17, 2013 Category: Urology & Nephrology Authors: Yu‐Hsuan Shao, Dirk F. Moore, Weichung Shih, Yong Lin, Thomas L. Jang, Grace L. Lu‐Yao Tags: Urological Oncology Source Type: research
Arterial Reconstruction for Atypical Mycotic Aneurysms
Our case involves a 67-year-old man with a post lung transplantation status for idiopathic pulmonary fibrosis, who was initially referred to our institution for treatment of left hip septic arthritis due to Pseudallescheria boydii infection. One month following total hip arthroplasty, he noticed left upper thigh swelling with duplex imaging consistent with a 7-cm mid-superficial femoral artery aneurysm with popliteal vein compression and associated deep venous thrombosis. During operative resection, exploration of his contralateral saphenous vein showed inadequate conduit for use. Therefore, we proceeded with proxima...
Source: Vascular and Endovascular Surgery - January 17, 2013 Category: Surgery Authors: Malinowski, M. J., Halandras, P. Tags: Clinical Research Articles Source Type: research
Factors associated with attrition in a longitudinal rheumatoid arthritis registry
Conclusions:The attrition rate for this registry was similar to rates reported by other registries. Shorter disease duration, higher disease activity, and several other socioeconomic factors were associated. Males and younger patients tended to dropout during the first year. Population differences in each registry may result in different attrition patterns and ultimately, each longitudinal registry should consider conducting its own analyses. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Christine K Iannaccone, Anne Fossel, Hsun Tsao, Jing Cui, Michael Weinblatt, Nancy Shadick Tags: Original Article Source Type: research
Assessment of hand involvement in systemic sclerosis by ultrasonography: Reply to the letter by Ingegnoli and Cuomo
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Muriel Elhai, Henri Guerini, Ramin Bazeli, Jerôme Avouac, Véronique Freire, Jean‐Luc Drapé, André Kahan, Yannick Allanore Tags: Reply to Letter to the editor Source Type: research
Quadriceps muscle mass and function in patients with the hypermobility type of Ehlers‐Danlos Syndrome
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Lies Rombaut Tags: Reply to Letter to the editor Source Type: research
Response to MCP implant surgery: Time for an RCT?
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: H. Myra Kim, Patricia B. Burns, Frank D. Burke, E. F. Shaw Wilgis, David A. Fox, Kevin C. Chung Tags: Reply to Letter to the editor Source Type: research
Assessment of hand involvement in systemic sclerosis by ultrasonography: Comment on the article by Elhai et al
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Francesca Ingegnoli, Giovanna Cuomo Tags: Letter to the editor Source Type: research
Mass of individual muscles in the lower extremity of women with Hypermobility Type Ehler‐Danlos syndrome
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Schikler Kenneth N Tags: Letter to the editor Source Type: research
Delineating the role of multiple intra‐articular corticosteroid injections in the management of juvenile idiopathic arthritis in the biologic era
Conclusion.Multiple IAC therapy induced sustained remission of joint synovitis in a substantial proportion of patients. A controlled trial comparing multiple IAC therapy and methotrexate versus methotrexate and a tumor necrosis factor antagonist is worthy of consideration. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Charalampia Papadopoulou, Mikhail Kostik, Maria Isabel Gonzalez‐Fernandez, Marek Bohm, Juan Carlos Nieto‐Gonzalez, Angela Pistorio, Stefano Lanni, Alessandro Consolaro, Alberto Martini, Angelo Ravelli Tags: Original Article Source Type: research
Fatigue and factors related to fatigue in rheumatoid arthritis: A systematic review
ConclusionThis review summarizes the current knowledge in the field in order to inform future research on causes and consequences of fatigue in RA. However, the results are based on cross‐sectional and longitudinal studies with different designs and different fatigue scales. For a better identification of causal associations between fatigue in RA and related factors, longitudinal prospective designs with adequate fatigue measurements are suggested. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Stephanie Nikolaus, Christina Bode, Erik Taal, Mart A.F.J. van de Laar Tags: Original Article Source Type: research
Long term physical functioning and its association with somatic comorbidity and comorbid depression in patients with established rheumatoid arthritis: A longitudinal study
Conclusion.Both somatic comorbidity and comorbid depression were negatively associated with physical functioning during an eleven‐year follow‐up period. Furthermore, their combination seems to be especially detrimental to physical functioning over time. These results emphasize the need to take somatic comorbidity and comorbid depression into account in the screening and treatment of patients with RA. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: J. van den Hoek, L.D. Roorda, H.C. Boshuizen, J. van Hees, I. Rupp, G.J. Tijhuis, J. Dekker, G.A.M. van den Bos Tags: Original Article Source Type: research
Current and maintained health‐enhancing physical activity in rheumatoid arthritis – the PARA 2010 study
Conclusion:To our knowledge this is the first study exploring maintained physical activity in a large well‐defined sample of persons with RA. Our results indicate that a minority perform maintained HEPA, including both aerobic physical activity and muscle strength training, and that psychosocial factors are the most salient and consistent in the explanation of HEPA variation. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Ingrid Demmelmaier, Patrick Bergman, Birgitta Nordgren, Irene Jensen, Christina H. Opava Tags: Original Article Source Type: research
Evidence of a systemic predisposition to chondrocalcinosis (CC) and association between CC and osteoarthritis at distant joints: A cross‐sectional study.
Conclusions:There is a systemic predisposition to the apparently sporadic CC. OA associates with CC at the same joint, and at distant joints, except hip OA which does not associate with hip CC, or with CC at distant joints. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Dr A. Abhishek, S. Doherty, R. Maciewicz, K. Muir, W. Zhang, M. Doherty Tags: Original Article Source Type: research
Gender and surgical outcomes and mortality after primary total knee arthroplasty: A risk‐adjusted analysis
Conclusion:Higher rates of mortality, hospital readmissions, revision surgery and wound infections in men undergoing elective primary TKA, compared to women, indicates gender disparity in these outcomes. © 2013 by the American College of Rheumatology
Source: Arthritis Care and Research - January 17, 2013 Category: Rheumatology Authors: Jasvinder A. Singh, C. Kent Kwoh, Diane Richardson, Wei Chen, Said A. Ibrahim Tags: Original Article Source Type: research
Scoring radiographic progression in ankylosing spondylitis: Should we use the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) or the Radiographic Ankylosing Spondylitis Spinal Score (RASSS)?
Conclusions: The determination of RASSS for radiographic damage of the spine is frequently impossible or strongly influenced by non-contributory imputation. In comparison to the mSASSS, the contribution of thoracic VCs in the RASSS-method is negligible, and does not justify the additional scoring efforts.
Source: Arthritis Research and Therapy - January 17, 2013 Category: Rheumatology Authors: Sofia RamiroAstrid van TubergenCarmen StolwijkRobert LandeweFilip van den BoschMaxime DougadosDesiree van der Heijde Source Type: research
Disclosure and Self-Report of Emotional, Social, and Physical Health in Children and Adolescents With Chronic Pain--A Qualitative Study of PROMIS Pediatric Measures
Conclusions Findings suggest the importance of a rigorous developmental approach for understanding the verbal and cognitive dimensions of pediatric self-reports and patient-reported outcomes.
Source: Journal of Pediatric Psychology - January 17, 2013 Category: Pediatrics Authors: Jacobson, C. J., Farrell, J. E., Kashikar-Zuck, S., Seid, M., Verkamp, E., DeWitt, E. M. Tags: Regular Articles Source Type: research
The role of human umbilical cord tissue-derived mesenchymal stromal cells (UCX(R)) in the treatment of inflammatory arthritis
Conclusion: The results suggest that UCX(R) cells may be an effective and promising new approach for treating both local and systemic manifestations of inflammatory arthritis.
Source: Journal of Translational Medicine - January 16, 2013 Category: Research Authors: Jorge SantosRita BárciaSandra SimõesManuela GasparSusana CaladoAna Água-DoceSílvia AlmeidaJoana AlmeidaMariana FilipeMariana TeixeiraJosé MartinsLuís GraçaMaria CruzPedro CruzHelder Cruz Source Type: research
Electrodermal Activity at Acupuncture Points Differentiates Patients with Current Pain from Pain-Free Controls.
This study evaluated whether electrodermal resistance at acupuncture points (AP) systematically varies as a function of pain. The study was conceived as a proof-of-principle study in support of research on acupuncture and other complementary medicine approaches. Specifically, this study investigates whether or not electrodermal activity systematically differentiates arthritis patients with current pain from pain-free controls. Participants with rheumatoid arthritis (n = 32) and a typical pain level of at least 3 (on a 0-10 scale) were compared with case controls (n = 28) who had no medical diagnosis and were pain free....
Source: Applied Psychophysiology and Biofeedback - January 16, 2013 Category: Psychiatry & Psychology Authors: Turner L, Linden W, Marshall C Tags: Appl Psychophysiol Biofeedback Source Type: research
[Retinal vein occlusion : Diagnosis or symptom?]
[Retinal vein occlusion : Diagnosis or symptom?] Ophthalmologe. 2013 Jan 16; Authors: Matlach J, Göbel W Abstract Behçet's disease is a chronic recurrent systemic vasculitis and can affect nearly all organ systems. Eye involvement is characterized by uveitis with occlusive retinal vasculitis. Oral aphthous ulcers are the major primary symptom and arthritis, genital ulcerations and skin lesions are common extraocular manifestations. Gastrointestinal and vascular symptoms or manifestations of the central nervous system are less frequently seen. Biologic agents are used alone or in combination with immunosup...
Source: Der Ophthalmologe - January 16, 2013 Category: Opthalmology Authors: Matlach J, Göbel W Tags: Ophthalmologe Source Type: research
Chlamydia trachomatis Is Present and Metabolically Active During the Remitting Phase in Synovial Tissues From Patients With Chronic Chlamydia-Induced Reactive Arthritis.
CONCLUSIONS:: Bacterial load in synovial tissue of patients with remitting disease is lower than that of active disease, but mRNAs encoding proinflammatory proteins are equal to or higher than those of active disease. Transcription in the host is attenuated for cytokines and chemokines. These initial results demonstrate that organism is present and metabolically active in synovium during the remitting phase of chronic Chlamydia-induced ReA and that the genetic events characterizing quiescence are complex. PMID: 23328833 [PubMed - as supplied by publisher]
Source: The American Journal of the Medical Sciences - January 16, 2013 Category: Journals (General) Authors: Gérard HC, Carter JD, Hudson AP Tags: Am J Med Sci Source Type: research
Impact of rheumatoid arthritis on quality of life, work productivity and resource utilisation: an observational, cross-sectional study in Brazil.
CONCLUSIONS: In Brazil, moderate to severe RA is associated with significant functional disability and morbidity. Disease severity should be considered when treating patients with RA. More aggressive treatment strategies may be needed to effectively manage patients with moderate to severe RA. PMID: 23324808 [PubMed - as supplied by publisher]
Source: Pain Physician - January 16, 2013 Category: Anesthesiology Authors: da Rocha Castelar Pinheiro G, Khandker RK, Sato R, Rose A, Piercy J Tags: Clin Exp Rheumatol Source Type: research
Illness perceptions in patients receiving rheumatology rehabilitation: association with health and outcomes at 12 months
Conclusion: Illness perceptions as measured by the RD-IPQ were associated with health and outcomes as measured by rheumatology-specific and generic instruments. The consideration of illness perceptions as a component of rehabilitation may be important in achieving desired outcomes.
Source: BMC Musculoskeletal Disorders - January 16, 2013 Category: Orthopaedics Authors: Ida LøchtingElin FjerstadAndrew Garratt Source Type: research
Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency
Conclusions: The data obtained with IL-33 KO mice indicate that endogenous IL-33 is not required for the development of joint inflammation in K/BxN serum transfer-induced arthritis. On the contrary, arthritis severity was reduced in ST2 KO mice. This observation might relate to IL-33 independent effects of ST2, and/or reveal the existence of confounding variables affecting the severity of joint inflammation in these KO strains.
Source: Arthritis Research and Therapy - January 16, 2013 Category: Rheumatology Authors: Praxedis MartinDominique Talabot-AyerChristian SeemayerSolenne VigneCeline LamacchiaEmiliana RodriguezAxel FinckhDirk SmithCem GabayGaby Palmer Source Type: research
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice
Abstract The metalloproteinase ADAMTS4/aggrecanase‐1 is highly expressed in cartilage and has been implicated in human arthritis. Although abundantly expressed in many types of cancer, its role in cancer remains unknown. In this work, we demonstrate for the first time that full‐length ADAMTS4 or its catalytically more active N‐terminal 53 kDa autocatalytic fragment both promote B16 melanoma growth and angiogenesis in mice. In contrast, overexpression of its catalytically‐inactive E362A mutant or truncated fragments containing only the C‐terminal ancillary domains suppresses melanoma growth and angiogenesis under ...
Source: International Journal of Cancer - January 15, 2013 Category: Cancer & Oncology Authors: Nithya Rao, Zhiyuan Ke, Hongrui Liu, Chao‐Jin Ho, Saran Kumar, Wei Xiang, Yizhun Zhu, Ruowen Ge Tags: Cancer Cell Biology Source Type: research
Prognostic contributions of the underlying inflammatory disease and acute organ dysfunction in critically ill patients with systemic rheumatic diseases.
CONCLUSION: Patients with SRD are mostly admitted in the ICU with infection or SRD exacerbation, and can be treated with immunosuppressive therapy and life-sustaining interventions with acceptable 30-day mortality. Death is associated with both the severity of the acute medical condition and the characteristics of the underlying SRD. PMID: 23332934 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - January 15, 2013 Category: Internal Medicine Authors: Faguer S, Ciroldi M, Mariotte E, Galicier L, Rybojad M, Canet E, Bengoufa D, Schlemmer B, Azoulay E Tags: Eur J Intern Med Source Type: research
Efficacy and Tolerability of Febuxostat in Hyperuricemic Patients With or Without Gout: A Systematic Review and Meta-Analysis.
CONCLUSION: Febuxostat was effective in reducing serum urate in hyperuricemic patients with/without gout, and febuxostat (40-120 mg/d) was more efficacious compared with allopurinol (100-300 mg/d). The doses of allopurinol to which febuxostat has been compared, although commonly prescribed, are low in the range of approved doses of allopurinol. The tolerability of febuxostat for the treatment of hyperuricemia with/without gout is similar to that of allopurinol. PMID: 23332451 [PubMed - as supplied by publisher]
Source: Clinical Therapeutics - January 15, 2013 Category: Drugs & Pharmacology Authors: Ye P, Yang S, Zhang W, Lv Q, Cheng Q, Mei M, Luo T, Liu L, Chen S, Li Q Tags: Clin Ther Source Type: research
Chromatographic and mass spectrometric fingerprinting analyses of Angelica sinensis (Oliv.) Diels-derived dietary supplements.
Abstract Angelica sinensis (Oliv.) Diels ("Danggui" in Chinese) is one of the most commonly used traditional Chinese medicines. It has been used to invigorate blood circulation for the treatment of anemia, hypertension, chronic bronchitis, asthma, rheumatism, and cardiovascular diseases. There are a number of A. sinensis-derived dietary supplements in the US markets. However, no study have been conducted to investigate the quality of these dietary supplements. In this paper, high-performance liquid chromatographic and flow-injection mass spectrometric fingerprints were both evaluated to assess the consistency of A....
Source: Analytical and Bioanalytical Chemistry - January 15, 2013 Category: Chemistry Authors: Zhao Y, Sun J, Yu LL, Chen P Tags: Anal Bioanal Chem Source Type: research
The SMILE Study -- Safety of Methotrexate in Combination with Leflunomide in Rheumatoid Arthritis.
CONCLUSION: The combination of MTX and LEF was well tolerated, with adverse events comparable to those of monotherapy and the other nonbiologic disease-modifying antirheumatic drug treatment group. PMID: 23322457 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Bird P, Griffiths H, Tymms K, Nicholls D, Roberts L, Arnold M, Burnet S, de Jager J, Scott J, Zochling J, Littlejohn G Tags: J Rheumatol Source Type: research
Cost-related Medication Nonadherence in Older Patients with Rheumatoid Arthritis.
CONCLUSION: Patients with RA experience a high prevalence of CRN and forgoing of basic needs, more than do older adults with multiple other chronic conditions. The situation did not improve during a period of policy change aimed at alleviating high drug costs. PMID: 23322458 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Harrold LR, Briesacher BA, Peterson D, Beard A, Madden J, Zhang F, Gurwitz JH, Soumerai SB Tags: J Rheumatol Source Type: research
Association of Guanosine Triphosphate Cyclohydrolase 1 Gene Polymorphisms with Fibromyalgia Syndrome in a Korean Population.
CONCLUSION: Our study provides evidence that certain GCH1 haplotypes may be protective against susceptibility and pain sensitivity in FM. Our data suggest that NO is responsible for pain sensitivity in the pathogenesis of FM. PMID: 23322459 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Kim SK, Kim SH, Nah SS, Lee JH, Hong SJ, Kim HS, Lee HS, Kim HA, Joung CI, Bae J, Choe JY, Lee SS Tags: J Rheumatol Source Type: research
Symptoms Related to Tumor Necrosis Factor Receptor 1-associated Periodic Syndrome, Multiple Sclerosis, and Severe Rheumatoid Arthritis in Patients Carrying the TNF Receptor Superfamily 1A D12E/p.Asp41Glu Mutation.
CONCLUSION: The clinical phenotype might be associated with the TNFRSF1A D12E mutation. There is a close pathophysiological relationship between TNF signaling and autoimmune disorders. PMID: 23322460 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Havla J, Lohse P, Gerdes LA, Hohlfeld R, Kümpfel T Tags: J Rheumatol Source Type: research
Comparative Effectiveness of Nonbiologic versus Biologic Disease-modifying Antirheumatic Drugs for Rheumatoid Arthritis.
CONCLUSION: Patients in both treatment groups generally experienced lower CDAI scores across time. Patients switching to bDMARD demonstrated greater improvement than patients switching to nonbiologic DMARD with both analytic approaches at 5 months. Relative advantages with bDMARD were observed at 9 and 24 months only with MV regression. These analyses provide a practical example of how findings in comparative effectiveness research can diverge with different methodological approaches. PMID: 23322461 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Dewitt EM, Li Y, Curtis JR, Glick HA, Greenberg JD, Anstrom KJ, Kremer JM, Reed G, Schulman KA, Reed SD Tags: J Rheumatol Source Type: research
A New Approach to Prevention of Knee Osteoarthritis: Reducing Medial Load in the Contralateral Knee.
CONCLUSION: In persons with medial OA, the contralateral knee is also at high risk of medial OA. Bilateral reduction in medial loading in knees by use of strategies such as lateral wedge insoles might not only reduce medial load in affected knees but prevent knee OA or its progression on the contralateral side. PMID: 23322462 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Jones RK, Chapman GJ, Findlow AH, Forsythe L, Parkes MJ, Sultan J, Felson DT Tags: J Rheumatol Source Type: research
BAFF Expression Correlates with Idiopathic Inflammatory Myopathy Disease Activity Measures and Autoantibodies.
CONCLUSION: These findings highlight the potential importance of BAFF, ΔBAFF, and BAFF-R in the pathogenesis of IIM, and suggest an important role in the assessment of disease activity. PMID: 23322463 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: De Padilla CM, McNallan KT, Crowson CS, Bilgic H, Bram RJ, Hein MS, Ytterberg SR, Amin S, Peterson EJ, Baechler EC, Reed AM Tags: J Rheumatol Source Type: research
Factors Influencing Concordance Between Clinical and Ultrasound Findings in Rheumatoid Arthritis.
CONCLUSION: Concordance between CJE and US is poor overall. US adds information to CJE, most notably at the metatarsophalangeal joints and shoulders. Usefulness is decreased for B-US when DAS28 is low and for PDUS when disease duration is short. PMID: 23322464 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Le Boedec M, Jousse-Joulin S, Ferlet JF, Marhadour T, Chales G, Grange L, Hacquard-Bouder C, Loeuille D, Sellam J, Albert JD, Bentin J, Chary-Valckenaere I, d'Agostino MA, Etchepare F, Gaudin P, Hudry C, Dougados M, Saraux A Tags: J Rheumatol Source Type: research
A Medicolegal Analysis of Worker Appeals for Fibromyalgia as a Compensable Condition Following Workplace Soft-tissue Injury.
CONCLUSION: Over half of appeals for aggravation or causation of FM following a work-related softtissue injury were accepted by the tribunal, with importance ascribed to a rheumatologist diagnosis. Concerns are raised regarding lengthy duration from injury to diagnosis, claimants' high healthcare use, and neglect of mention of previous health status. The attribution of causation of FM to a softtissue workplace traumatic event is contentious and requires further examination. PMID: 23322465 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Fitzcharles MA, Ste-Marie PA, Shir Y Tags: J Rheumatol Source Type: research
Tocilizumab Inhibits Structural Joint Damage and Improves Physical Function in Patients with Rheumatoid Arthritis and Inadequate Responses to Methotrexate: LITHE Study 2-year Results.
CONCLUSION: Compared with placebo-MTX, tocilizumab-MTX significantly inhibited structural joint damage and improved physical function in patients with RA who previously had inadequate response to MTX. An extension of this study is continuing and will provide additional longterm efficacy and safety data. National Clinical Trials registry NCT00106535. PMID: 23322466 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Fleischmann RM, Halland AM, Brzosko M, Burgos-Vargas R, Mela C, Vernon E, Kremer JM Tags: J Rheumatol Source Type: research
The Relationship Between Cognitive Function and Physical Function in Rheumatoid Arthritis.
CONCLUSION: Cognitive impairment was significantly associated with greater functional limitations in patients with RA, suggesting that cognitive impairment may play a role in poor functional status in persons with RA. PMID: 23322467 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Shin SY, Julian L, Katz P Tags: J Rheumatol Source Type: research
Carotid Plaque Characteristics and Disease Activity in Rheumatoid Arthritis.
CONCLUSION: Patients with RA had more CP compared with controls and patients in CDAI remission, and controls had more stable CP than patients with active disease; these findings point to the importance of achieving remission in RA. PMID: 23322468 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Semb AG, Rollefstad S, Provan SA, Kvien TK, Stranden E, Olsen IC, Hisdal J Tags: J Rheumatol Source Type: research
Three-dimensional Volumetric Ultrasound: A Valid Method for Blinded Assessment of Response to Therapy in Rheumatoid Arthritis.
CONCLUSION: The results of our pilot study suggest that volumetric PDUS can be responsive and repeatable in multicenter cohort studies of RA. This technique may minimize assessment biases and reduce acquisition variability in open-label and observational studies. PMID: 23322469 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Naredo E, Acebes C, Brito E, Agustín JJ, de Miguel E, Mayordomo L, Möller I, Moragues C, Rejón E, Rodriguez A, Uson J, Garrido J, Martínez-Hernández D, , The Ultrasound School of the Spanish Society of Rheumatology Tags: J Rheumatol Source Type: research
Identification of Immunogenic HLA-B*27:05 Binding Peptides of Salmonella Outer Membrane Protein in Patients with Reactive Arthritis and Undifferentiated Spondyloarthropathy.
CONCLUSION: Nine novel immunogenic OMP peptides binding to HLA-B*27:05 were identified that showed sequence similarity with other arthritogenic bacteria. PMID: 23322470 [PubMed - as supplied by publisher]
Source: J Rheumatol - January 15, 2013 Category: Rheumatology Authors: Singh AK, Aggarwal A, Chaurasia S, Misra R Tags: J Rheumatol Source Type: research