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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Lab Notes: BP Drugs Cut Brain Amyloid
(MedPage Today) -- Antihypertensive agents from different classes significantly reduced beta-amyloid protein plaques in a mouse model of Alzheimer's disease. Also this week: a master gene for autoimmune disease. (Source: MedPage Today Rheumatology)
Source: MedPage Today Rheumatology - June 7, 2013 Category: Rheumatology Source Type: news

Lumbar Disc Degeneration in Osteoporotic Men: Prevalence and Assessment of the Relation with Presence of Vertebral Fracture.
CONCLUSION: In osteoporotic men, the prevalence of lumbar spine degeneration is high. There is no relationship between lumbar disc degeneration and the presence of vertebral fracture in osteoporotic men. PMID: 23729808 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: Fabreguet I, Fechtenbaum J, Briot K, Paternotte S, Roux C Tags: J Rheumatol Source Type: research

Employment of a needs assessment survey to shape a novel web-based pediatric rheumatology curriculum for primary care providers
Conclusions: We will utilize our survey results to develop a learner centered curriculum to have the highest positive impact in assisting primary care providers in caring for children with rheumatologic diseases. (Source: Pediatric Rheumatology)
Source: Pediatric Rheumatology - June 5, 2013 Category: Rheumatology Authors: Amy WoodwardZena Harris Source Type: research

Psoriasis, psoriatic arthritis and increased risk of incident Crohn's disease in US women
Conclusions Psoriasis with concomitant psoriatic arthritis is associated with an increased risk of incident CD. (Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - May 30, 2013 Category: Rheumatology Authors: Li, W.-Q., Han, J.-L., Chan, A. T., Qureshi, A. A. Tags: Inflammatory bowel disease, Open access, Degenerative joint disease, Musculoskeletal syndromes, Epidemiology Clinical and epidemiological research Source Type: research

Microbes, the gut and ankylosing spondylitis
It is increasingly clear that the interaction between host and microbiome profoundly affects health. There are 10 times more bacteria in and on our bodies than the total of our own cells, and the human intestine contains approximately 100 trillion bacteria. Interrogation of microbial communities by using classic microbiology techniques offers a very restricted view of these communities, allowing us to see only what we can grow in isolation. However, recent advances in sequencing technologies have greatly facilitated systematic and comprehensive studies of the role of the microbiome in human health and disease. Comprehensiv...
Source: Arthritis Research and Therapy - June 6, 2013 Category: Rheumatology Authors: Mary-Ellen CostelloDirk ElewautTony KennaMatthew Brown Source Type: research

Patient perspectives on achieving T2T goals: A critical examination of patient reported outcomes
Conclusions Achievement a lower disease activity disease state, especially T2T goals, was associated with further improvement in PROs, albeit modest in magnitude. © 2013 American College of Rheumatology. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - June 5, 2013 Category: Rheumatology Authors: Jeffrey R Curtis, Ying Shan, Leslie Harrold, Jie Zhang, Jeffrey D Greenberg, George W Reed Tags: Brief Report Source Type: research

Serum Pyridinoline Levels and Prediction of Severity of Joint Destruction in Rheumatoid Arthritis.
CONCLUSION: Increased pyridinoline serum levels, both at baseline and during the disease course, are associated with more severe joint destruction during the coming year(s), although the predictive accuracy as a sole predictor was moderate. PMID: 23729802 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: Krabben A, Knevel R, Huizinga TW, Cavet G, van der Helm-van Mil AH Tags: J Rheumatol Source Type: research

Should We Redefine Treatment Targets in Rheumatoid Arthritis? Low Disease Activity Is Sufficiently Strict for Patients Who Are Anticitrullinated Protein Antibody-negative.
CONCLUSION: At the same level of inflammation, ACPA-negative patients have less joint damage and lower probability for damage in newly affected joints than ACPA-positive patients. Low disease activity might be a sufficiently strict treatment target for ACPA-negative patients to prevent progression of joint damage. PMID: 23729803 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: de Punder YM, Hendrikx J, den Broeder AA, Pascual EV, van Riel PL, Fransen J Tags: J Rheumatol Source Type: research

The submaximal heart and pulmonary evaluation: A novel noninvasive test to identify pulmonary hypertension in patients with systemic sclerosis
Conclusions ∆PETCO2 on the step test has a strong, statistically significant negative correlation with mPAP on RHC. © 2013 American College of Rheumatology. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - June 5, 2013 Category: Rheumatology Authors: Elana J. Bernstein, Lisa A. Mandl, Jessica K. Gordon, Robert F. Spiera, Evelyn M. Horn Tags: Brief Report Source Type: research

Sustained Clinical Remission and Rate of Relapse After Tocilizumab Withdrawal in Patients with Rheumatoid Arthritis.
CONCLUSION: Longterm clinical remission is possible in a number of patients with RA after suspension of TCZ. This effect has also been reported with other biologic agents. Additional data are required to support recommendations for discontinuing a biological agent after achieving remission. PMID: 23729804 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: Aguilar-Lozano L, Castillo-Ortiz JD, Vargas-Serafin C, Morales-Torres J, Sanchez-Ortiz A, Sandoval-Castro C, Padilla-Ibarra J, Hernandez-Cuevas C, Ramos-Remus C Tags: J Rheumatol Source Type: research

Bilateral Evaluation of the Hand and Wrist in Untreated Early Inflammatory Arthritis: A Comparative Study of Ultrasonography and Magnetic Resonance Imaging.
CONCLUSION: 3.0-T MRI identified a higher prevalence of synovitis in comparison to US in an early polyarthritis cohort. Both techniques have good diagnostic performance for RA although MRI reveals a significantly higher diagnostic capability. Synovitis of carpal joints and of flexor tendons as identified by MRI were the most powerful predictors of progression toward RA. In patients with US joint and tendon counts ≤ 10, MRI can significantly improve the diagnostic performance of the 2010 ACR/EULAR classification criteria. PMID: 23729806 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: Navalho M, Resende C, Rodrigues AM, Pereira da Silva JA, Fonseca JE, Campos J, Canhão H Tags: J Rheumatol Source Type: research

Tackling the challenges of systemic sclerosis associated pulmonary hypertension: One step forward
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 5, 2013 Category: Rheumatology Authors: Paul M. Hassounand, Majid Shafiq Tags: Editorial Source Type: research

Subcutaneously Administered Ofatumumab in Rheumatoid Arthritis: A Phase I/II Study of Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics.
CONCLUSION: Treatment of RA patients with SC ofatumumab doses of 30 mg or higher resulted in profound and prolonged B cell depletion in blood. Single doses up to 60 mg were tolerated without glucocorticoid premedication. (ClinicalTrials.gov identifier NCT00686868). PMID: 23729801 [PubMed - as supplied by publisher] (Source: J Rheumatol)
Source: J Rheumatol - June 1, 2013 Category: Rheumatology Authors: Kurrasch R, Brown JC, Chu M, Craigen J, Overend P, Patel B, Wolfe S, Chang DJ Tags: J Rheumatol Source Type: research

Efficacy and Safety of Ocrelizumab in Active Proliferative Lupus Nephritis: Results from the Randomized, Double‐Blind Phase III BELONG Study
Conclusion. In patients with active LN, ORR rates with OCR were numerically but not statistically significantly superior to placebo. OCR treatment was associated with a higher rate of serious infections in the subgroup receiving background MMF. ClinicalTrials.gov Identifier: NCT00626197 © 2013 American College of Rheumatology. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - June 5, 2013 Category: Rheumatology Authors: Eduardo F. Mysler, Alberto J. Spindler, Renato Guzman, Marc Bijl, David Jayne, Richard A. Furie, Frédéric A. Houssiau, Jorn Drappa, David Close, Romeo Maciuca, Kajal Rao, Saba Shahdad, Paul Brunetta Tags: Full Length Source Type: research

Original paper The role of adipokines in the pathogenesis of systemic sclerosis – original results and short literature review
The increased interest in the role of white adipose tissue started in 1994 with the discovery of leptin. Nowadays adipose tissue is perceived as an endocrine organ that in addition to regulation of fat mass produces a large number of bioactive mediators, called adipokines, which among other things can regulate the function of brain, liver, skeletal muscles and the immune system. In the present article we briefly summarize the current data on the role of adipokines in the pathogenesis of rheumatic diseases, particularly systemic sclerosis. (Source: Articles of Rheumatology - TERMEDIA publishing house)
Source: Articles of Rheumatology - TERMEDIA publishing house - April 8, 2010 Category: Rheumatology Source Type: research

Case report Scleroderma-like syndrome in a patient with primary biliary cirrhosis
Primary biliary cirrhosis (PBC) is a chronic, progressive autoimmune disease of the liver marked by slow progressive destruction of the small interlobular bile ducts that leads to cholestasis, jaundice, liver cirrhosis and liver failure. Various skin manifestations have been described in patients with PBC including pruritus, skin excoriations, skin hyperpigmentation, scleroderma, morphea, lichen sclerosus et atrophicus, granuloma annulare, and atypical urticaria. In this paper we present a case of a 34-year old woman with PBC accompanied by scleroderma-like skin syndrome. (Source: Articles of Rheumatology - TERMEDIA publishing house)
Source: Articles of Rheumatology - TERMEDIA publishing house - April 8, 2010 Category: Rheumatology Source Type: research

Infliximab-induced discoid lupus erythematosus.
We present a case of rheumatoid arthritis which developed such an eruption after treatment with infliximab. The lesions resolved after the discontinuation of infliximab. In the present case, the clinical, serological and immunohistochemical features of our patient are discussed with the literature. PMID: 23554040 [PubMed - in process] (Source: Lupus)
Source: Lupus - April 1, 2013 Category: Rheumatology Authors: Cemil BC, Atas H, Canpolat F, Akca Y, Sasmaz R Tags: Lupus Source Type: research

Table of Contents
(Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - June 1, 2013 Category: Rheumatology Tags: Frontmatter Source Type: research

Masthead
(Source: Seminars in Arthritis and Rheumatism)
Source: Seminars in Arthritis and Rheumatism - June 1, 2013 Category: Rheumatology Tags: Frontmatter Source Type: research

Proceedings of the 2013 Rheumatology Winter Clinical Symposia
Advances in rheumatology occur at a rapid pace and staying abreast of important changes is a challenge for all. Both novel drug development and enhanced understanding of conventional or historic therapies have molded current day rheumatologic practice. Rheumatology has led the way in the use of outcome measures and imaging modalities in common disorders like rheumatoid arthritis, osteoarthritis, and gout. The expertise of the rheumatologist has widened such that knowledge of economics, legal issues, related disorders and extraarticular disease is essential. In February 2013, the 6th annual Rheumatology Winter Clinical Symp...
Source: Seminars in Arthritis and Rheumatism - June 1, 2013 Category: Rheumatology Authors: Arthur Kavanaugh, Roy Fleischmann, Martin Jan Bergman, Eric Ruderman, Orrin Troum, Alvin F. Wells, George Martin, Leonard H. Calabrese, Allan Gibofsky, Vibeke Strand, John J. Cush Source Type: research