Stem Cells 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
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Rapid Heterotrophic Ossification with Cryopreserved Poly(ethylene glycol-) Microencapsulated BMP2-Expressing MSCs
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In this study we used mesenchymal stem cells (MSCs) due to their ease of harvest, replication potential, and immunomodulatory capabilities. MSCs were from sheep and pig due to their appeal as large animal models for bone nonunion. We demonstrated that cryopreservation of these microencapsulated MSCs did not affect their cell viability, adenoviral BMP2 production, or ability to initiate bone formation. Additionally, microspheres showed no appreciable damage from cryopreservation when examined with light and electron microscopy. These results validate the use of cryopreservation in preserving the viability and functionality ...
Source: Computational Intelligence and Neuroscience - February 7, 2012 Category: Neuroscience Source Type: research
Directing Stem Cells To Increase Bone Formation And Bone StrengthEmail this article to a colleague.
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A research team led by UC Davis Health System scientists has developed a novel technique to enhance bone growth by using a molecule which, when injected into the bloodstream, directs the body's stem cells to travel to the surface of bones. Once these cells are guided to the bone surface by this molecule, the stem cells differentiate into bone-forming cells and synthesize proteins to enhance bone growth... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 7, 2012 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news
Acid attack model gets sight backEmail this article to a colleague.
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A model who was left blind in one eye after acid was thrown in her face tells of her joy after having her sight restored using stem cell treatment. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 6, 2012 Category: Consumer Health News Source Type: news
Spheroid Formation and Neural Induction in Human Adipose-Derived Stem Cells on a Chitosan-Coated SurfaceEmail this article to a colleague.
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Cells Tissues Organs (DOI:10.1159/000332045) (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - February 6, 2012 Category: Cytology Source Type: research
After Stem Cell Transplant, Children Soon Recover EmotionallyAfter Stem Cell Transplant, Children Soon Recover EmotionallyEmail this article to a colleague.
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A surprising new study shows that most children make a complete emotional recovery after stem cell transplantation. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 6, 2012 Category: Consumer Health News Tags: Pediatrics News Source Type: news
Scientists make strides toward fixing infant heartsEmail this article to a colleague.
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(Rice University) Researchers at Rice University and Texas Children's Hospital have turned stem cells from amniotic fluid into cells that form blood vessels. Their success offers hope that such stem cells may be used to grow tissue patches to repair infant hearts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2012 Category: Global & Universal Source Type: news
Hormel Institute study makes key finding in stem cell self-renewalEmail this article to a colleague.
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(University of Minnesota) A University of Minnesota-led research team has proposed a mechanism for the control of whether embryonic stem cells continue to proliferate and stay stem cells, or differentiate into adult cells like brain, liver or skin. The work has implications in two areas. In cancer treatment, it is desirable to inhibit cell proliferation. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2012 Category: Global & Universal Source Type: news
Exercise triggers stem cells in muscleEmail this article to a colleague.
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(University of Illinois at Urbana-Champaign) University of Illinois researchers determined that an adult stem cell present in muscle is responsive to exercise, a discovery that may provide a link between exercise and muscle health. The findings could lead to new therapeutic techniques using these cells to rehabilitate injured muscle and prevent or restore muscle loss with age. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 6, 2012 Category: Global & Universal Source Type: news
Stromal cells from term fetal membrane are highly suppressive in allogeneic settings in vitro.Email this article to a colleague.
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Abstract
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) have immunosuppressive properties and have been used to treat steroid-refractory acute graft-versus-host disease (GVHD) in stem cell transplant patients. Cells with similar capacities can also be found in term placental tissue. We have isolated stromal cells from term fetal membrane (FMSCs), umbilical cords (UCSCs) and placental villi (PVSCs) as well as from bone marrow and compared their immunoregulatory capacity in allogeneic settings. We found that FMSCs and UCSCs suppressed proliferation significantly in mixed lymphocyte reactions (MLRs), whereas ...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Karlsson H, Erkers T, Nava S, Ruhm S, Westgren M, Ringdén O Tags: Clin Exp Immunol Source Type: research
The fibroblast growth factor signaling axis controls cardiac stem cell differentiation through regulating autophagy.Email this article to a colleague.
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Abstract
The fibroblast growth factor (FGF) signaling axis plays important roles in heart development. Yet, the molecular mechanism by which the FGF regulates cardiogenesis is not fully understood. Using genetically engineered mouse and in vitro cultured embryoid body (EB) models, we demonstrate that FGF signaling suppresses premature differentiation of heart progenitor cells, as well as autophagy in outflow tract (OFT) myocardiac cells. The FGF also promotes mesoderm differentiation in embryonic stem cells (ESCs) but inhibits cardiomyocyte differentiation of the mesoderm cells at later stages. Furthermore, inhibit...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Zhang J, Liu J, Liu L, McKeehan WL, Wang F Tags: Autophagy Source Type: research
Researchers develop method of directing stem cells to increase bone formation and bone strengthEmail this article to a colleague.
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(University of California - Davis Health System) A research team led by UC Davis Health System scientists has developed a novel technique to enhance bone growth by using a molecule which, when injected into the bloodstream, directs the body's stem cells to travel to the surface of bones. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 5, 2012 Category: Global & Universal Source Type: news
Neurotrophins-Growth Factors UpdateEmail this article to a colleague.
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Our Neurotrophins and Growth Factor Antibodies and Recombinant Proteins help support a wide span of research areas. These areas include: neuroscience, immunology, cardiac disease research and cancer.I would like to update you on recent publications highlighting use of some of these reagents: Aiko Sada, Kazuteru Hasegawa, Pui Han Pin, Yumiko Saga. NANOS2 Acts Downstream of Glial Cell Line-Derived Neurotrophic Factor Signaling to Suppress Differentiation of Spermatogonial Stem Cells. DOI: 10.1002/stem.790. Copyright © 2011 AlphaMed Press...anti-GFRA1 (1:200, Neuromics, Edina, MN)...Images: Ngn3-Cre targets GFRA1-n...
Source: Neuromics - February 4, 2012 Category: Neuroscience Tags: TrkB beta-Neural Growth Factor PDGF-C BDNF antibody Immunofluorescence PDGFR Alpha Antibody Immunohistochemistry cancer markers GDNF expression CD140A antibody Neurotrophin Antibodies beta NGF Source Type: news
Treating Brain Injuries With Stem Cell Transplants - Promising ResultsEmail this article to a colleague.
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The February edition of Neurosurgery reports that animal experiments in brain-injured rats have shown that stem cells injected via the carotid artery travel directly to the brain, greatly enhancing functional recovery... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Neurology / Neuroscience Source Type: news
Primary Involvement of NADPH Oxidase 4 in Hypoxia-Induced Generation of Reactive Oxygen Species in Adipose-Derived Stem CellsEmail this article to a colleague.
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Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - February 3, 2012 Category: Stem Cells Tags: article Source Type: research
Myeloproliferative NeoplasmsEmail this article to a colleague.
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Critical Concepts and Managementseries:Hematologic MalignanciesMyeloproliferative neoplasms (MPNs) are clonal stem cell diseases that, under the World Health Organization classification, are subcategorized into eight clinicopathologic entities. The current book focuses on three of these categories: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. A number of important questions regarding the diagnosis, prognosis, and treatment of ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - February 3, 2012 Category: Databases & Libraries Tags: Hematology Source Type: news
Hepatitis Research May Benefit From Stem CellsEmail this article to a colleague.
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Hepatitis C is a viral disease that leads to inflammation and organ failure. However, researchers are puzzled as to why some individuals are very susceptible to the disease, while others are not. Researchers believe they could find out how genetic variations produce these different responses by investigating liver cells from different individuals in the lab. However, liver cells are hard to obtain and extremely challenging to grow in a lab dish as they often lose their normal function and structure when removed from the body... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
PPAR{gamma} agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcomaEmail this article to a colleague.
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Myxoid round cell liposarcoma (MRCLS) is a common liposarcoma subtype characterized by a translocation that results in the fusion protein TLS:CHOP as well as by mixed adipocytic histopathology. Both the etiology of MRCLS and the mechanism of action of TLS:CHOP remain poorly understood. It was previously shown that ET-743, an antitumor compound with an unclear mechanism of action, is highly effective in patients with MRCLS. To identify the cellular origin of MRCLS, we engineered a mouse model in which TLS:CHOP was expressed under the control of a mesodermally restricted promoter (Prx1) in a p53-depleted background. This mod...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Elizabeth Charytonowicz, Melissa Terry, Katherine Coakley, Leonid Telis, Fabrizio Remotti, Carlos Cordon-Cardo, Robert N. Taub, Igor Matushansky Source Type: research
Aerodynamically assisted bio-jetting of hematopoietic stem cellsEmail this article to a colleague.
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Analyst, 2012, Advance ArticleDOI: 10.1039/C2AN16027G, CommunicationEmmanuel Griessinger, Suwan N. Jayasinghe, Dominique BonnetAerodynamically assisted bio-jets, the emergence of a novel sheathless flow cell technology for flow cytometry.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Analyst latest articles)
Source: RSC - Analyst latest articles - February 3, 2012 Category: Chemistry Authors: Emmanuel Griessinger Source Type: research
Febuary eFactorEmail this article to a colleague.
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Weis addresses industrial hygiene group on mineral fibers
LST fellow makes a move from lab bench to global health
Former NIEHS staff fellow named vice chancellor
Staffers and trainees gain toxicology certification
NIH turns 125
Public health officials work to keep research first during a tough economy
Prins honored by University of Illinois at Chicago
NIEHS Public Interest Partner honored
Superfund promotes safe drinking water at Agua Fria Festival
Registration is underway for NIEHS and HHS national research conference
NTP toxicologist Kamal Abdo remembered
Minisymposium brings epigenetic experts to NIEHS
BPA r...
Source: Environmental Factor - NIEHS Newsletter - February 3, 2012 Category: Environmental Health Source Type: news
Comparative Analysis of Paracrine Factor Expression in Human Adult Mesenchymal Stem Cells Derived from Bone Marrow, Adipose, and Dermal TissueEmail this article to a colleague.
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Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - February 3, 2012 Category: Stem Cells Tags: article Source Type: research
A New Efficient Protocol for Directed Differentiation of Retinal Pigmented Epithelial Cells from Normal and Retinal Disease Induced Pluripotent Stem CellsEmail this article to a colleague.
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Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - February 3, 2012 Category: Stem Cells Tags: article Source Type: research
Positive Data Presented on Athersys' MultiStem to Treat StrokeEmail this article to a colleague.
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CLEVELAND and NEW ORLEANS, Feb. 3, 2012 (GLOBE NEWSWIRE) -- Medical researchers from The University of Texas Health Science Center at Houston (UTHealth) Medical School presented new research results this morning at the American Heart Association International Stroke Conference that highlight the role of the spleen in the mechanisms underlying how MultiStem(r), a novel allogenic stem cell therapy being developed by Athersys, Inc. (Nasdaq:ATHX), reduces damage and enhances functional recovery in animals after an ischemic stroke. (Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - February 3, 2012 Category: Pharmaceuticals Source Type: news
Livedo reticularis associated with autoimmune hemolytic anemia: prolonged remission induced by peripheral blood stem cell transplantation relapse after 10 years and restoration of hemoglobin levels by rituximabEmail this article to a colleague.
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A anemia hemolítica autoimune (AHAI) é uma doença na qual são produzidos anticorpos diretamente contra as glicoproteínas adsorvidas na superfície da membrana dos eritrócitos. Algumas medicações e outras associações têm sido implicadas. Descrevemos e discutimos um caso de livedo reticular associado à AHAI tratado com transplante de células-tronco de sangue periférico (TCTSP) e que entrou em total remissão por 10 anos. Após esse período, a paciente apresentou recaída, foi tratada com anticorpo anti-CD20 (rituximabe), e atualmente encontra-se em total remissão. O papel do TCTSP e o uso de rituximabe no tra...
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
Stem Cells Could Drive Hepatitis Research ForwardEmail this article to a colleague.
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Hepatitis C, an infectious disease that can cause inflammation and organ failure, has different effects on different people. But no one is sure why some people are very susceptible to the infection, while others are resistant. Scientists believe that if they could study liver cells from different people in the lab, they could determine how genetic differences produce these varying responses. However, liver cells are difficult to obtain and notoriously difficult to grow in a lab dish because they tend to lose their normal structure and function when removed from the body... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
New international standards to aid data sharingEmail this article to a colleague.
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Led by researchers at University of Oxford (UK) and the Harvard Stem Cell Institute (HSCI) at Harvard University, (USA), more than 50 collaborators at over 30 scientific organizations around the globe have agreed on a common standard for integrating biological data sets. This will make it possible to consistently describe the enormous and radically different databases that are compiled in the biosciences in fields ranging from genetics to stem cell science, to environmental studies.This collaborative effort provides a way for scientists in widely disparate life science fields to co-ordinate each other's findings by allowin...
Source: MEDEV News - February 3, 2012 Category: Universities & Medical Training Source Type: news
Eclipse Therapeutics Appoints Hans Clevers, M.D., Ph.D., and Thomas...Email this article to a colleague.
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Eclipse Therapeutics, Inc., a biotechnology company dedicated to the discovery and development of novel therapeutics that target cancer stem cells, announced today the appointments of Hans Clevers,...(PRWeb February 01, 2012)Read the full story at http://www.prweb.com/releases/2012/2/prweb9155733.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - February 3, 2012 Category: Pharmaceuticals Source Type: news
An osteosarcoma zebrafish model implicates Mmp‐19 and Ets‐1 as well as reduced host immune response in angiogenesis and migrationEmail this article to a colleague.
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AbstractAbout 40% of osteosarcoma patients die of metastases. Novel strategies to improve treatment of metastatic patients require a better understanding of the processes involved, like angiogenesis, migration and the immune response. However the rarity of osteosarcoma and its heterogeneity make this neoplasm difficult to study. Recently we reported malignant transformation of mouse mesenchymal stem cells (MSCs) which formed osteosarcoma upon transplantation into mice. Here we studied these cells in zebrafish embryos and found that transformed MSCs induced angiogenesis and migrated through the bodies of the embryos, but th...
Source: The Journal of Pathology - February 3, 2012 Category: Pathology Authors: Alexander B. MohsenyWei XiaoRalph CarvalhoHerman P. SpainkPancras C.W. HogendoornAnne‐Marie Cleton‐Jansen Tags: Original Paper Source Type: research
Regulation of Bmi1 in Colon Cancer [Signal Transduction]Email this article to a colleague.
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B lymphoma Mo-MLV insertion region 1 (Bmi1) is a Polycomb Group (PcG) protein important in gene silencing. It is a component of Polycomb Repressive Complex 1 (PRC1), which is required to maintain the transcriptionally repressive state of many genes. Bmi1 was initially identified as an oncogene that regulates cell proliferation and transformation, and is important in hematopoiesis and the development of nervous systems. Recently, it was reported that Bmi1 is a potential marker for intestinal stem cells. Because Wnt signaling plays a key role in intestinal stem cells, we analyzed the effects of Wnt signaling on Bmi1 expressi...
Source: Journal of Biological Chemistry - February 3, 2012 Category: Chemistry Authors: Yu, T., Chen, X., Zhang, W., Colon, D., Shi, J., Napier, D., Rychahou, P., Lu, W., Lee, E. Y., Weiss, H. L., Evers, B. M., Liu, C. Tags: Molecular Bases of Disease Source Type: research
Allogeneic mesenchymal stem cell transplantation in seven patients with refractory inflammatory bowel diseaseEmail this article to a colleague.
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We refer to two articles by Duijvestein et al and Ciccocioppo et al1 2 in which the authors suggest that administration of autologous bone marrow-derived mesenchymal stem cells (MSCs) is safe and feasible in the treatment of refractory Crohn's disease (CD). However, to date there are few data about allogeneic MSC transplantation (MSCT) for patients with inflammatory bowel disease (IBD). We wish to report our experience of allogeneic MSCT in seven patients with IBD. Infused allogeneic MSCs were obtained from the bone marrow or umbilical cord. Bone marrow was aspirated from healthy relatives of three patients. Umbilical cord...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Liang, J., Zhang, H., Wang, D., Feng, X., Wang, H., Hua, B., Liu, B., Sun, L. Tags: PostScript Source Type: research
A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancerEmail this article to a colleague.
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Epithelial to mesenchymal transition (EMT) correlates with high-grade malignancy including the competence to form metastases. In addition, EMT has recently been linked to cellular self-renewal programmes of cancer stem cells and apoptosis/anoikis resistance, which are all features of therapeutic resistance. The EMT programme is driven by several transcription factors (TFs), such as the transcriptional regulators SNAIL, SLUG, ZEB1 and ZEB2 and the basic helix–loop–helix factors E47 and TWIST. These proteins target and repress the CDH1 gene, which encodes for E-cadherin, an important caretaker of the epithelial s...
Source: Gut - February 3, 2012 Category: Gastroenterology Authors: Schneider, G., Kramer, O. H., Saur, D. Tags: Commentary Source Type: research
Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm Treated with Allogenic Stem Cell TransplantationEmail this article to a colleague.
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We report a 15‐year‐old boy with blastic plasmacytoid dendritic cell neoplasm who was treated with acute myeloid leukemia‐based polychemotherapy and subsequent allogenic stem cell transplantation. (Source: Pediatric Dermatology)
Source: Pediatric Dermatology - February 3, 2012 Category: Dermatology Authors: THILO GAMBICHLERIOANNA PANTELAKIMARKUS STÜCKER Tags: BRIEF REPORT Source Type: research
Optimality in the Development of Intestinal CryptsEmail this article to a colleague.
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Shalev Itzkovitz, Irene C. Blat, Tyler Jacks, Hans Clevers, Alexander van Oudenaarden. Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigat.... (Source: Cell)
Source: Cell - February 2, 2012 Category: Cytology Source Type: research
Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosusEmail this article to a colleague.
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This study aimed to assess the efficacy of UC-MSCT in the
treatment of SLE-associated DAH. Four SLE patients complicated with DAH, who underwent UC-MSCT, were included. Clinical changes
before and after transplantation were assessed by measurements of hemoglobin, platelet level, oxygen saturation, and serological
factors. High-resolution CT (HRCT) scans of the chest were performed to evaluate pulmonary manifestation. All the four patients
showed dramatic improvements of their clinical manifestations. Hemoglobin was elevated after UC-MSCT and was sustained at
a normal level 6 months after UC-MSCT in the four patie...
Source: Clinical Rheumatology - February 2, 2012 Category: Rheumatology Tags: Clinical Rheumatology Source Type: research
Post injury changes in the properties of mesenchymal stem cells derived from human anterior cruciate ligamentsEmail this article to a colleague.
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Conclusions Our results suggest that colony-forming and differentiation potential decrease over time. It is important to consider changes
in properties of MSCs and use ACL tissue in the acute phase of rupture when biological manipulation is required.
Content Type Journal ArticleCategory Original PaperPages 1-8DOI 10.1007/s00264-012-1484-yAuthors
Shuya Nohmi, Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562 JapanYuji Yamamoto, Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036...
Source: International Orthopaedics - February 2, 2012 Category: Orthopaedics Tags: International Orthopaedics Source Type: research
Role of ∝7-Nicotinic Acetylcholine Receptor in Normal and Cancer Stem Cells.Email this article to a colleague.
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Abstract
The α7-nicotinic acetylcholine receptor (α7-nAChR) is widely known as a neurotransmitter receptor in nervous systems. α7-nAChR is also present in a variety of non-neuronal tissues, where it has been implicated in the regulation of essential cellular functions including proliferation, survival, differentiation and communication. We have recently found in breast cancer that α7-nAChR is involved in the proliferation of cancer stem cells, which constitute a minor subpopulation responsible for tumor development and metastasis. Since growing evidence suggests that α7-nAChR is present not only in mature tiss...
Source: Current Drug Targets - February 2, 2012 Category: Drugs & Pharmacology Authors: Lin W, Hirata N, Sekino Y, Kanda Y Tags: Curr Drug Targets Source Type: research
Autologous transplantation of bone marrow–derived mesenchymal stem cells: a promising therapeutic strategy for prevention of skin‐graft contractionEmail this article to a colleague.
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SummaryHypertrophic scars resutl from abnormal healing of severe burns, and are characterized by loss of the original structure and function of the skin. Transplantation of autologous split skin is the preferred treatment after scar excision; however, there will be some unavoidable degree of contraction within the grafts. To our knowledge, it is very rare that bone marrow‐derived mesenchymal stem cells (BM‐MSCs) have been used for the treatment of skin‐graft contraction. However, in our clinics, we found that during a 2‐year follow‐up analysis, areas treated with autologous BM‐MSCs combined with transplantation...
Source: Clinical And Experimental Dermatology - February 2, 2012 Category: Dermatology Authors: Y. XuS. HuangX. Fu Tags: Clinical dermatology • Source Type: research
Expression of putative stem marker nestin and CD133 in advanced serous ovarian cancer.Email this article to a colleague.
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The objective of the studies was to explore if the stem cell biomarkers could be used to predict the tumor chemotherapy-resistance in serous ovarian cancer patients. Expression of two putative stem cell markers CD133 and nestin, and vascular epithelial growth factor (VEGF) and epidermal growth factor receptor (EGFR) were detected in 123 cases of advanced serous ovarian cancer specimens by immunohistochemistry. To estimate intra-tumoral microvessel density (MVD), CD34 immunostaining was also performed. CD133 and nestin were defined to be positive in 35.0% and 32.5% of the serous ovarian carcinoma tissues, respectively. It w...
Source: Neoplasma - February 2, 2012 Category: Cancer & Oncology Authors: Qin Q, Sun Y, Fei M, Zhang J, Jia Y, Gu M, Xia R, Chen S, Deng A Tags: Neoplasma Source Type: research
Clinicopathological significance of non-small cell lung cancer with high prevalence of Oct-4 tumor cellsEmail this article to a colleague.
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Conclusion:
Our findings suggest that, even in the context of vulnerable MVD status and VEGF expression, overexpression of Oct-4 in tumor tissue represents a prognostic factor in primary NSCLC patients. Oct-4 may maintain NSCLC cells in a poorly differentiated state through a mechanism that depends on promoting cell proliferation. (Source: Journal of Experimental and Clinical Cancer Research)
Source: Journal of Experimental and Clinical Cancer Research - February 2, 2012 Category: Cancer & Oncology Authors: Zhenguang ChenTao WangLie CaiChunhua SuBeilong ZhongYiyan LeiAndy Peng Xiang Source Type: research
Evaluation of metabolic syndrome after hematopoietic stem cell transplantation in children and adolescentsEmail this article to a colleague.
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ConclusionsThe prevalence of MS was 32%, which was significantly higher than in a healthy pediatric population. We recommend prolonged follow‐up for transplant recipients, coupled with enforcement of preventive measures, such as early diagnosis and encouragement of a healthy lifestyle. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 2, 2012 Category: Cancer & Oncology Authors: Claudia ParisLorena YatesPamela LamaAna J. ZepedaDaniela GutiérrezJulia Palma Tags: Research Article Source Type: research
Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessmentEmail this article to a colleague.
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Benzene causes acute myeloid leukemia and probably other hematological malignancies. As benzene also causes hematotoxicity even in workers exposed to levels below the US permissible occupational exposure limit of 1 part per million, further assessment of the health risks associated with its exposure, particularly at low levels, is needed. Here, we describe the probable mechanism by which benzene induces leukemia involving the targeting of critical genes and pathways through the induction of genetic, chromosomal or epigenetic abnormalities and genomic instability, in a hematopoietic stem cell (HSC); stromal cell dysregulati...
Source: Carcinogenesis - February 2, 2012 Category: Cancer & Oncology Authors: McHale, C. M., Zhang, L., Smith, M. T. Tags: REVIEWS Source Type: research
Tocotrienol as a potential anticancer agentEmail this article to a colleague.
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Vitamin E is composed of two structurally similar compounds: tocopherols (TPs) and tocotrienols (T3). Despite being overshadowed by TP over the past few decades, T3 is now considered to be a promising anticancer agent due to its potent effects against a wide range of cancers. A growing body of evidence suggests that in addition to its antioxidative and pro-apoptotic functions, T3 possesses a number of anticancer properties that make it superior to TP. These include the inhibition of epithelial-to-mesenchymal transitions, the suppression of vascular endothelial growth factor tumor angiogenic pathway and the induction of ant...
Source: Carcinogenesis - February 2, 2012 Category: Cancer & Oncology Authors: Ling, M. T., Luk, S. U., Al-Ejeh, F., Khanna, K. K. Tags: REVIEWS Source Type: research
Extracellular Nucleotide Inhibits Cell Proliferation and Negatively Regulates Toll-like Receptor 4 Signaling in Human Progenitor Endothelial Cells.Email this article to a colleague.
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Abstract
Extracellular nucleotides mediate a wide range of physiological effects by interacting with plasma membrane P2 purinergic receptors. Recently, it had been reported that P2 receptors are expressed in certain kinds of stem cells, and function to induce cytokine expression and to modulate cell proliferation. In the present study, we analyzed the expression and the function of P2 receptors in human umbilical cord blood-derived EPCs. We demonstrated here that EPCs expressed P2X4,6,7 and P2Y2,4,11,13,14 receptors and extracellular ATP inhibited EPCs proliferation. In accord with our previous study, we found that...
Source: Cell Biology International - February 2, 2012 Category: Cytology Authors: Xiao Z, Yang M, Li F, Lv Q, He Q, Deng M, Liu X, Chen X, Chen M, Xie X, Hu J Tags: Cell Biol Int Source Type: research
Efficient generation of adipocytes in a dishEmail this article to a colleague.
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A protocol for efficient differentiation of human pluripotent stem cells into white and brown adipocytes now enables their detailed examination at a cellular and molecular level, facilitating the study of adipocyte dysfunction in a range of metabolic diseases including diabetes, heart disease and obesity. (Source: Nature Cell Biology)
Source: Nature Cell Biology - February 2, 2012 Category: Cytology Authors: Andrew G. ElefantyEdouard G. Stanley Tags: News and Views Source Type: research
Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injuryEmail this article to a colleague.
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CONCLUSIONS• The results obtained show that multiple biological processes are associated with injury and repair of the CN and provide a systematic genome‐wide screen for neurotrophic and/or inhibitory pathways of nerve regeneration.• These data identify the candidate genes that may be utilized in novel molecular‐based therapies for the preservation and protection of the CN during radical prostatectomy. (Source: BJU International)
Source: BJU International - February 2, 2012 Category: Urology & Nephrology Authors: Giulia CalendaTravis D. StrongChristian P. PavlovichEdward M. SchaefferArthur L. BurnettWayne YuKelvin P. DaviesTrinity J. Bivalacqua Source Type: research
Deregulation of apoptosis-related genes is associated with PRV1 overexpression and JAK2 V617F allele burden in Essential Thrombocythemia and MyelofibrosisEmail this article to a colleague.
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Conclusions:
Our results suggest the participation of intrinsic apoptosis pathway in the MPN physiopathology. In addition, PRV1 and JAK2 V617F allele burden were linked to deregulation of the apoptotic machinery. (Source: Journal of Hematology and Oncology)
Source: Journal of Hematology and Oncology - February 2, 2012 Category: Hematology Authors: Raquel TognonElainy GasparottoRenata NevesNatalia NunesAline FerreiraPatricia PalmaSimone KashimaDimas CovasMary SantanaElizabeth SoutoMaria Aparecida ZanichelliBelinda SimoesAna Maria SouzaFabiola Castro Source Type: research
Predictive factors for inadequate stem cell mobilization in Chinese patients with NHL and HL: 14‐year experience of a single‐center studyEmail this article to a colleague.
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Conclusion: Our analysis showed that high amounts of chemotherapy, radiotherapy, low platelet count, chemosensitive recurrent patients, combination chemotherapy plus G‐CSF and low CD34+ cells in BM prior to mobilization could emerged as important predictive factors for mobilization failure in Chinese patients with NHL and HL. J. Clin. Apheresis, 2012. © 2012 Wiley Periodicals, Inc. (Source: Journal of Clinical Apheresis)
Source: Journal of Clinical Apheresis - February 2, 2012 Category: Hematology Authors: Xiaohong HanLi MaLingdi ZhaoXiaohui HePeng LiuShengyu ZhouJianliang YangYan QinSheng YangJiarui YaoYuankai Shi Tags: Research Article Source Type: research
A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin ribosideEmail this article to a colleague.
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Gene regulatory networks that govern hematopoietic stem cells (HSCs) and leukemia-initiating cells (L-ICs) are deeply entangled. Thus, the discovery of compounds that target L-ICs while sparing HSC is an attractive but difficult endeavor. Presently, most screening approaches fail to counter-screen compounds against normal hematopoietic stem/progenitor cells (HSPCs). Here, we present a multistep in vitro and in vivo approach to identify compounds that can target L-ICs in acute myeloid leukemia (AML). A high-throughput screen of 4000 compounds on novel leukemia cell lines derived from human experimental leukemogenesis models...
Source: Blood - February 2, 2012 Category: Hematology Authors: McDermott, S. P., Eppert, K., Notta, F., Isaac, M., Datti, A., Al-awar, R., Wrana, J., Minden, M. D., Dick, J. E. Tags: Hematopoiesis and Stem Cells, Myeloid Neoplasia Source Type: research
ECSASB2 mediates MLL degradation during hematopoietic differentiationEmail this article to a colleague.
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Mixed lineage leukemia (MLL) is a key epigenetic regulator of normal hematopoietic development and chromosomal translocations involving MLL are one of the most common genetic alterations in human leukemia. Here we show that ASB2, a component of the ECSASB E3 ubiquitin ligase complex, mediates MLL degradation through interaction with the PHD/Bromodomain region of MLL. Forced expression of ASB2 degrades MLL and reduces MLL transactivation activity. In contrast, the MLL-AF9 fusion protein does not interact with ASB2 and is resistant to ASB2 mediated degradation. Increased expression of ASB2 during hematopoietic differentiatio...
Source: Blood - February 2, 2012 Category: Hematology Authors: Wang, J., Muntean, A. G., Hess, J. L. Tags: Hematopoiesis and Stem Cells Source Type: research
A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized miceEmail this article to a colleague.
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In conclusion, this new LV will facilitate HSC-based gene therapy by directly targeting these primitive cells in BM aspirates or total cord blood. Most importantly, in the future, RDTR/SCF-LVs might completely obviate ex vivo handling and simplify gene therapy for many hematopoietic defects because of their applicability to direct in vivo inoculation. (Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Frecha, C., Costa, C., Negre, D., Amirache, F., Trono, D., Rio, P., Bueren, J., Cosset, F.-L., Verhoeyen, E. Tags: Gene Therapy Source Type: research
High-dose melphalan and peripheral blood stem cell transplantation for light-chain amyloidosis with cardiac involvementEmail this article to a colleague.
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High-dose melphalan (HDM) plus stem cell transplantation is an effective treatment for light-chain amyloidosis (AL), but is associated with high treatment-related mortality in patients with cardiac involvement. We studied 187 patients with cardiac involvement with AL who underwent HDM between 1996 and 2008. The median age was 57 years and the median time from diagnosis to HDM was 3.6 months. Half of the patients received reduced-dose melphalan (100-160 mg/m2). The median overall survival (OS) was 66 months, 54 months from diagnosis and HDM, respectively, and 91 patients (49%) were alive at the last follow-up 52 months (med...
Source: Blood - February 2, 2012 Category: Hematology Authors: Madan, S., Kumar, S. K., Dispenzieri, A., Lacy, M. Q., Hayman, S. R., Buadi, F. K., Dingli, D., Rajkumar, S. V., Hogan, W. J., Leung, N., Grogan, M., Gertz, M. A. Tags: Free Research Articles, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
