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This page shows you the most recent publications within this specialty of the MedWorm directory.

Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
JAK2 activity is tightly controlled through a self-inhibitory effect via its JAK homology domain 2 (JH2), which restricts the strength and duration of JAK2/STAT3 signaling under physiological conditions. Although multiple mutations within JAK2, which abrogate the function of JH2 and sustain JAK2 activation, are widely observed in hematological malignancies, comparable mutations have not been detected in solid tumors. How solid tumor cells override the autoinhibitory effect of the JH2 domain to maintain constitutive activation of JAK2/STAT3 signaling remains puzzling. Herein, we demonstrate that AGK directly interacted with...
Source: Journal of Clinical Investigation - May 12, 2013 Category: Biomedical Science Authors: Xiuting Chen, Zhe Ying, Xi Lin, Huanxin Lin, Jueheng Wu, Mengfeng Li, Libing Song Source Type: research

Transplantation KCNMA1 modified bone marrow‐mesenchymal stem cell therapy for diabetes mellitus‐induced erectile dysfunction
This study assessed the effect of KCNMA1 transfected bone marrow‐mesenchymal stem cells (BM‐MSCs) on the improvement of erectile function in diabetic rats. Sixty male Sprague–Dawley rats were injected with streptozotocin (STZ) and screened with apomorphine (APO) to establish diabetes mellitus‐induced erectile dysfunction (DMED). DMED rats were randomly divided into four groups: rats in each group underwent intracavernous injection with either phosphate buffer solution (DMED+PBS), nontransfected MSCs (DMED+MSCs), empty vector transfected MSCs (DMED+null‐MSCs) or KCNMA1 transfected MSCs (DMED+KCNMA1‐MSCs). Before...
Source: Andrologia - May 11, 2013 Category: Urology & Nephrology Authors: Y. He, W. He, G. Qin, J. Luo, M. Xiao Tags: Original Article Source Type: research

Stem Cell Injection Research Study Now Enrolling at the Arizona Pain...
The new Arizona Pain Stem Cell Institute is beginning a research project involving...(PRWeb May 09, 2013)Read the full story at http://www.prweb.com/releases/stemcellinjections/painmanagementarizona/prweb10716458.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - May 11, 2013 Category: Pharmaceuticals Source Type: news

Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2
Abstract: Bone morphogenetic proteins (BMPs) are effective for bone regeneration, and are used clinically. However, supraphysiological doses are required, which limits their use. Cartilage oligomeric matrix protein is an extracellular matrix protein, which we have previously shown can bind to growth factors of the TGFs family, suggesting that COMP may also bind to BMP-2. Rather than being a passive component of the matrix, COMP may serve as an “instructive matrix” component capable of increasing local growth factor concentration, slowing the diffusion of growth factors, and promoting their biological activity. The purp...
Source: Bone - May 11, 2013 Category: Orthopaedics Authors: Kazunari Ishida, Chitrangada Acharya, Blaine A. Christiansen, Jasper H.N. Yik, Paul E. DiCesare, Dominik R. Haudenschild Tags: Original Articles Source Type: research

UCLA stem cell researchers move toward treatment for rare genetic nerve disease
Led by Dr. Peiyee Lee and Dr. Richard Gatti, researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have used induced pluripotent stem (iPS) cells to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia (A-T). Their discovery shows the positive effects of drugs that may lead to effective new treatments for the neurodegenerative disease. iPS cells are made from patients' skin cells, rather than from embryos, and they can become any type of cells, including brain cells, in the laboratory. The study appears online ahead of print in the jour...
Source: UCLA Newsroom: Health Sciences - May 10, 2013 Category: Universities & Medical Training Source Type: news

Young blood may help rejuvenate old hearts
Conclusion This study finds that sharing the circulation of young and old mice appears to reverse the age-related thickening of heart muscle cells in the older animal, and it seems this could be due to a certain growth factor in the blood of the young animal. The findings will be of scientific interest, and further our understanding of the processes of heart ageing in animals. However, the findings have very limited direct relevance to humans, and do not suggest a new treatment for heart failure. It is also certainly unknown at this point whether increasing levels of this factor in the blood of people with this type of he...
Source: NHS News Feed - May 10, 2013 Category: Consumer Health News Tags: Genetics/stem cells Heart/lungs Medical practice Source Type: news

Bone morphogenetic protein 6 stimulates mineralization in human dental follicle cells without dexamethasone
Conclusion: These findings suggest that hDFCs can differentiate to osteogenic lineage cells osteogenic induction medium without DEX, and BMP6 is a key gene in the osteogenic differentiation of hDFCs, and has therapeutic utility for bone regeneration and bone research. (Source: Archives of Oral Biology)
Source: Archives of Oral Biology - May 10, 2013 Category: Dentistry Authors: Kosuke Takahashi, Naomi Ogura, Haruna Aonuma, Ko Ito, Daisuke Ishigami, Yoshikazu Kamino, Toshirou Kondoh Tags: Stem cells Source Type: research

Comparison of the differentiation potential of neural crest derived progenitor cells from apical papilla (dNC-PCs) and stem cells from exfoliated deciduous teeth (SHED) into mineralising cells
Conclusion: Our results suggest that dNC-PCs are precursors for primary odontoblasts, whereas SHED differentiate into replacement odontoblasts. These different odontogenic differentiation potentials of dNC-PCs and SHED have to be considered for cellular therapies and tissue engineering approaches in the future. (Source: Archives of Oral Biology)
Source: Archives of Oral Biology - May 10, 2013 Category: Dentistry Authors: Martin Gosau, Werner Götz, Oliver Felthaus, Tobias Ettl, Andreas Jäger, Christian Morsczeck Tags: Stem cells Source Type: research

Transplanted Human Brain Cells Grow In Mice
A key type of human brain cell developed in the laboratory grows seamlessly when transplanted into the brains of mice, UC San Francisco researchers have discovered, raising hope that these cells might one day be used to treat people with Parkinson's disease, epilepsy, and possibly even Alzheimer's disease, as well as complications of spinal cord injury such as chronic pain and spasticity... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Natural Fibres Biologically Effective For Use In Stem Cell Cartilage Repair
Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a 'smart material' that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Arthritis / Rheumatology Source Type: news

mHCN4 Genetically Modified Canine Mesenchymal Stem Cells Provide Biological Pacemaking Function in Complete Dogs with Atrioventricular Block
ConclusionTransplantation of mHCN4‐modified cMSCs provided a stable biological pacemaking function that allowed an appropriate chronotropic response to physical exercise for up to 6 weeks. (Source: Pacing and Clinical Electrophysiology : PACE)
Source: Pacing and Clinical Electrophysiology : PACE - May 10, 2013 Category: Cardiology Authors: WEI LU, NONG YAOMING, RAN BOLI, CHENG JUN, ZHANG CHANGHAI, ZHOU YANG, SONG ZHIYUAN Tags: Original Article Source Type: research

UCLA stem cell researchers move toward treatment for rare genetic nerve disease
(University of California - Los Angeles) UCLA researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have used induced pluripotent stem cells (iPSC) to advance disease-in-a-dish modeling of a rare genetic disorder, ataxia telangiectasia. Their discovery shows positive effects of drugs that may lead to effective new treatments for the neurodegenerative disease. iPSC are made from patient skin cells rather than from embryos and can become any type of cells in the laboratory. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 10, 2013 Category: Global & Universal Source Type: news

Development and resolution of secondary autoimmunity after autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: competition of plasma cells for survival niches?
Haematopoietic stem cell transplantation (HSCT) is an effective treatment for severe autoimmune diseases such as systemic lupus erythematosus (SLE).1 However, it is increasingly recognised that these patients have an added propensity to develop secondary autoimmune disorders.2 3 Here, we report on a 21-year-old male patient who received a CD34-selected autologous HSCT following conditioning with antithymocyte-globulin and cyclophosphamide (CYC) after written informed consent for refractory, severe SLE with renal, haematological, mucocutaneous and musculoskeletal manifestations (SLEDAI 19).1 Clinical remission was achieved ...
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Alexander, T., Schneider, S., Hoyer, B., Cheng, Q., Thiel, A., Ziemer, S., Burmester, G.-R., Arnold, R., Radbruch, A., Hiepe, F. Tags: Letters Source Type: research

Stem cell therapy for tendinopathy: lessons from a large animal model
Introduction Tendon disorders compromise pain-free activity and often progress to chronic pain with a major impact on quality of life. Achilles tendinopathy (AT) is particularly common with many proposed therapies. However, apart from eccentric loading exercises, none have been shown to be more effective than placebo.1 Even the recent popular use of platelet-rich plasma has shown poor efficacy.2 3 There is therefore a clear need for new effective non-surgical treatments. Mesenchymal stem cells (MSCs) offer the potential for tendon regeneration and improved functional outcome via either direct or paracrine effects. We have ...
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Smith, R. K. W. Tags: Achilles tendinitis Abstracts from the 2nd International Scientific Tendinopathy Symposium (Vancouver, 2012) Source Type: research

Factors affecting tendinopathogenesis
Discussion We have demonstrated that MSC injections can be effective in reducing surgically-induced tendon pathology and that timing of injection is critically important to the long-term benefit. The in vitro changes in MSC expression suggest that both the tenocytes and the condition of the extracellular environment determine the secretome of the injected cells, and that the MSCs are responding to feedback from their immediate environment. MSCs have potential in the development of a cellular therapy to treat tendinopathy that develops after injury. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Smith, M. M., Ravi, V., Dart, A. J., Sonnabend, D. H., Little, C. B. Tags: Abstracts from the 2nd International Scientific Tendinopathy Symposium (Vancouver, 2012) Source Type: research

Effects of mast cells on the function of isolated human tenocytes
Discussion These findings suggest that either through physical association with tenocytes and/or release of mediators, mast cells could play a role in the regulation and activation of tenocytes. Further studies are underway to investigate the molecular mechanisms of mast cell-tenocyte interactions and whether these could play a role in the pathogenesis of tendinopathy. (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Behzad, H., Scott, A. Tags: Abstracts from the 2nd International Scientific Tendinopathy Symposium (Vancouver, 2012) Source Type: research

Stem cells, angiogenesis and muscle healing: a potential role in massage therapies?
Skeletal muscle injuries are among the most common and frequently disabling injuries sustained by athletes. Repair of injured skeletal muscle is an area that continues to present a challenge for sports medicine clinicians and researchers due, in part, to complete muscle recovery being compromised by development of fibrosis leading to loss of function and susceptibility to re-injury. Injured skeletal muscle goes through a series of coordinated and interrelated phases of healing including degeneration, inflammation, regeneration and fibrosis. Muscle regeneration initiated shortly after injury can be limited by fibrosis which...
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Best, T. M., Gharaibeh, B., Huard, J. Tags: Complementary medicine, Physiotherapy Review Source Type: research

Strategies for Isolating and Enriching Cancer Stem Cells: Well Begun Is Half Done
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 9, 2013 Category: Stem Cells Tags: article Source Type: research

Two UCLA faculty elected to National Academy of Sciences
Two professors from the David Geffen School of Medicine at UCLA have been elected by their peers to the prestigious National Academy of Sciences in recognition of their distinguished and continuing achievements in original research. Election to the academy is considered one of the highest honors presented to scientists in the U.S.; its membership includes Albert Einstein, Robert Oppenheimer, Thomas Edison, Orville Wright and Alexander Graham Bell. The UCLA professors are among 84 new members of the academy from across the U.S. and 21 foreign associates from 14 countries. Their election brings the number...
Source: UCLA Newsroom: Health Sciences - May 9, 2013 Category: Universities & Medical Training Source Type: news

Expression of the Human FSHD-Linked DUX4 Gene Induces Neurogenesis During Differentiation of Murine Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 9, 2013 Category: Stem Cells Tags: article Source Type: research

Turning old hearts
(Harvard University) Two Harvard Stem Cell Institute researchers have identified a protein in the blood of mice and humans that may prove to be the first effective treatment for the form of age-related heart failure that affects millions of Americans. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 9, 2013 Category: Global & Universal Source Type: news

Salk researchers chart epigenomics of stem cells that mimic early human development
(Salk Institute) Scientists have long known that control mechanisms known collectively as "epigenetics" play a critical role in human development, but they did not know precisely how alterations in this extra layer of biochemical instructions in DNA contribute to development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 9, 2013 Category: Global & Universal Source Type: news

6-Formylindolo (3,2-b)carbazole (FICZ) enhances retinoic acid (RA)-induced differentiation of HL-60 myeloblastic leukemia cells
Conclusions: Our data suggest that FICZ modulates intracellular signaling pathways and enhances RA-induced differentiation. (Source: Molecular Cancer)
Source: Molecular Cancer - May 9, 2013 Category: Cancer & Oncology Authors: Rodica BunaciuAndrew Yen Source Type: research

The myelodysplastic syndrome as a prototypical epigenetic disease
The myelodysplastic syndrome (MDS) is a clonal disorder characterized by increased stem cell proliferation coupled with aberrant differentiation resulting in a high rate of apoptosis and eventual symptoms related to bone marrow failure. Cellular differentiation is an epigenetic process that requires specific and highly ordered DNA methylation and histone modification programs. Aberrant differentiation in MDS can often be traced to abnormal DNA methylation (both gains and losses of DNA methylation genome wide and at specific loci) as well as mutations in genes that regulate epigenetic programs (TET2 and DNMT3a, both involve...
Source: Blood - May 9, 2013 Category: Hematology Authors: Issa, J.-P. J. Tags: Myeloid Neoplasia, Review Articles, Review Series, Clinical Trials and Observations Source Type: research

GATA2 haploinsufficiency caused by mutations in a conserved intronic element leads to MonoMAC syndrome
Previous reports of GATA2 mutations have focused on the coding region of the gene or full gene deletions. We recently identified 2 patients with novel insertion/deletion mutations predicted to result in mRNA nonsense-mediated decay, suggesting haploinsufficiency as the mechanism of GATA2 deficient disease. We therefore screened patients without identified exonic lesions for mutations within conserved noncoding and intronic regions. We discovered 1 patient with an intronic deletion mutation, 4 patients with point mutations within a conserved intronic element, and 3 patients with reduced or absent transcription from 1 allele...
Source: Blood - May 9, 2013 Category: Hematology Authors: Hsu, A. P., Johnson, K. D., Falcone, E. L., Sanalkumar, R., Sanchez, L., Hickstein, D. D., Cuellar-Rodriguez, J., Lemieux, J. E., Zerbe, C. S., Bresnick, E. H., Holland, S. M. Tags: Hematopoiesis and Stem Cells Source Type: research

Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells
In an attempt to discover novel growth factors for hematopoietic stem and progenitor cells (HSPCs), we have assessed cytokine responses of cord blood (CB)–derived CD34+ cells in a high-content growth factor screen. We identify the immunoregulatory chemokine (C-C motif) ligand 28 (CCL28) as a novel growth factor that directly stimulates proliferation of primitive hematopoietic cells from different ontogenetic origins. CCL28 enhances the functional progenitor cell content of cultured cells by stimulating cell cycling and induces gene expression changes associated with survival. Importantly, addition of CCL28 to culture...
Source: Blood - May 9, 2013 Category: Hematology Authors: Karlsson, C., Baudet, A., Miharada, N., Soneji, S., Gupta, R., Magnusson, M., Enver, T., Karlsson, G., Larsson, J. Tags: Hematopoiesis and Stem Cells, Brief Reports Source Type: research

FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs
Mixed-lineage leukemia (MLL)–AF4 fusion arises prenatally in high-risk infant acute pro-B-lymphoblastic leukemia (pro-B-ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hematoendothelial specification but was insufficient for transformation, suggesting that additional oncogenic insults seem required for MLL-AF4–mediated transformation. MLL-AF4+ pro-B-ALL expresses enormous levels of FLT3, occasionally because of activating mutations, thus representing a candidate cooperating event in MLL-AF4+ pro-B-ALL. Here, we explored the developmental impact of FLT3 activation alone, or together with MLL-AF4, in ...
Source: Blood - May 9, 2013 Category: Hematology Authors: Bueno, C., Ayllon, V., Montes, R., Navarro-Montero, O., Ramos-Mejia, V., Real, P. J., Romero-Moya, D., Arauzo-Bravo, M. J., Menendez, P. Tags: Hematopoiesis and Stem Cells, Lymphoid Neoplasia Source Type: research

A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease
Damage to the gastrointestinal tract during graft-versus-host disease (GVHD) is one of the major causes of morbidity and mortality in allogeneic hematopoietic stem cell transplant (HSCT) recipients. In the current study, we identified a critical role for the retinoic acid (RA) signaling pathway in the induction and propagation of gastrointestinal GVHD. The administration of exogenous RA significantly increased expression of the gut-homing molecules, CCR9 and α4β7, on donor T cells in mesenteric lymph nodes, and augmented the accumulation of proinflammatory CD4+ and CD8+ T cells within the gut mucosa, leading to ...
Source: Blood - May 9, 2013 Category: Hematology Authors: Chen, X., Dodge, J., Komorowski, R., Drobyski, W. R. Tags: Transplantation Source Type: research

Use of V(D)J recombination excision circles to identify T- and B-cell defects and to monitor the treatment in primary and acquired immunodeficiencies
T-cell receptor excision circles (TRECs) and kappa-deleting recombination excision circles (KRECs) are circular DNA segments generated in T and B cells during their maturation in the thymus and bone marrow. These circularized DNA elements persist in the cells, are unable to replicate, and are diluted as a result of cell division, thus are considered markers of new lymphocyte output. The quantification of TRECs and KRECs, which can be reliably performed using singleplex or duplex real-time quantitative PCR, provides novel information in the management of T- and B-cell immunity-related diseases. In primary immunodeficiencies...
Source: Journal of Translational Medicine - May 9, 2013 Category: Research Authors: Federico SeranaMarco ChiariniCinzia ZanottiAlessandra SottiniDiego BertoliAndrea BosioLuigi CaimiLuisa Imberti Source Type: research

Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma
In this study, we investigated the effect on airway remodeling and airway inflammation by administrating BMSCs in chronic asthmatic mice. Forty‐eight female BALB/c mice were randomly distributed into PBS group, BMSCs treatment group, BMSCs control group, and asthmatic group. The levels of cytokine and immunoglobulin in serum and bronchoalveolar lavage fluid were detected by enzyme‐linked immunosorbent assay. The number of CD4+CD25+regulatory T cells and morphometric analysis was determined by flow cytometry, hematoxylin‐eosin, immunofluorescence staining, periodic‐acid Schiff, and masson staining, respectively. We ...
Source: Journal of Cellular Biochemistry - May 9, 2013 Category: Biochemistry Authors: Xiahui Ge, Chong Bai, Jianming Yang, Guoliang Lou, Qiang Li, Ruohua Chen Tags: Article Source Type: research

Non insulin producing cell line, MIA PaCa‐2 is rendered insulin producing in vitro via mesenchymal epithelial transition
Abstract We used non‐insulin producing pancreatic carcinoma cell line, MIA PaCa‐2 and have modulated its culture conditions by using 1% matrigel as extracellular matrix, N2, B27 growth supplements and serum free conditions. Expression of markers was analyzed using qRT‐PCR, immunofluorescence and in vitro functional assay for insulin and C‐peptide release was assessed using insulin and C‐peptide ELISA, respectively. The cells grown under this altered culture conditions have exhibited a transition in the morphology from mesenchymal to epithelial with extensive piling up of cells. A reduction in doubling time from 4...
Source: Journal of Cellular Biochemistry - May 9, 2013 Category: Biochemistry Authors: Bipasha Bose, Sudheer Shenoy P Tags: Article Source Type: research

Human Embryonic Stem Cell-Derived Cardiomyocytes Migrate in Response to Gradients of Fibronectin and Wnt5a
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 8, 2013 Category: Stem Cells Tags: article Source Type: research

Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Wei Xie, Matthew D. Schultz, Ryan Lister, Zhonggang Hou, Nisha Rajagopal, Pradipta Ray, John W. Whitaker, Shulan Tian, R. David Hawkins, Danny Leung, Hongbo Yang, Tao Wang, Ah Young Lee, Scott A. Swanson, Jiuchun Zhang, Yun Zhu, Audrey Kim, Joseph R. Nery, Mark A. Urich, Samantha Kuan, Chia-an Yen, Sarit Klugman, Pengzhi Yu, Kran Suknuntha, Nicholas E. Propson, Huaming Chen, Lee E. Edsall, Ulrich Wagner, Yan Li, Zhen Ye, Ashwinikumar Kulkarni, Zhenyu Xuan, Wen-Yu Chung, Neil C. Chi, Jessica E. Antosiewicz-Bourget, Igor Slukvin, Ron Stewart, Michael Q. Zhang, Wei Wang, James A. Thomson, Joseph R. Ecker, Bing R...
Source: Cell - May 8, 2013 Category: Cytology Source Type: research

Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells
Casey A. Gifford, Michael J. Ziller, Hongcang Gu, Cole Trapnell, Julie Donaghey, Alexander Tsankov, Alex K. Shalek, David R. Kelley, Alexander A. Shishkin, Robbyn Issner, Xiaolan Zhang, Michael Coyne, Jennifer L. Fostel, Laurie Holmes, Jim Meldrim, Mitchell Guttman, Charles Epstein, Hongkun Park, Oliver Kohlbacher, John Rinn, Andreas Gnirke, Eric S. Lander, Bradley E. Bernstein, Alexander Meissner. Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to study the regulatory mechanisms that facilitate cellular transitions in a human context. To that end, we perf.... (Source: Cell)
Source: Cell - May 8, 2013 Category: Cytology Source Type: research

Cancer Headlines from Johns Hopkins (with audio)
(MedPage Today) -- Cancer Headlines is a monthly podcast from Johns Hopkins that focuses solely on oncology news. This month's topics include blood tests to monitor cancers during treatment, a biomarker for lung cancer, and stem cells to treat brain cancer. (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - May 8, 2013 Category: Hematology Source Type: news

Blood Vessel-Derived Stem Cells for Meniscal RegenerationBlood Vessel-Derived Stem Cells for Meniscal Regeneration
Learn more on blood vessel-derived stem cells -- and the role can they play in meniscal regeneration. Medicine and Science in Sports and Exercise (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 8, 2013 Category: Consumer Health News Tags: Orthopaedics Journal Article Source Type: news

Low-Level Shear Stress Induces Human Mesenchymal Stem Cell Migration Through the SDF-1/CXCR4 Axis Via MAPK Signaling Pathways
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 8, 2013 Category: Stem Cells Tags: article Source Type: research

Adult Cells Transformed Into Early-Stage Nerve Cells, Bypassing The Pluripotent Stem Cell Stage
A University of Wisconsin-Madison research group has converted skin cells from people and monkeys into a cell that can form a wide variety of nervous-system cells - without passing through the do-it-all stage called the induced pluripotent stem cell, or iPSC. Bypassing the ultraflexible iPSC stage was a key advantage, says senior author Su-Chun Zhang, a professor of neuroscience and neurology. "IPSC cells can generate any cell type, which could be a problem for cell-based therapy to repair damage due to disease or injury in the nervous system... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 8, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Customizable, Three-Dimensional Bone Grafts Created From Skin Cells
A team of New York Stem Cell Foundation (NYSCF) Research Institute scientists report the generation of patient-specific bone substitutes from skin cells for repair of large bone defects. The study, led by Darja Marolt, PhD, a NYSCF-Helmsley Investigator and Giuseppe Maria de Peppo, PhD, a NYSCF Research Fellow, and published in the Proceedings of the National Academy of Sciences of the USA, represents a major advance in personalized reconstructive treatments for patients with bone defects resulting from disease or trauma... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 8, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Drosophila Offer Clues To Understanding How Stem Cells Produce Different Kinds Of Cells
The human body contains trillions of cells, all derived from a single cell, or zygote, made by the fusion of an egg and a sperm. That single cell contains all the genetic information needed to develop into a human, and passes identical copies of that information to each new cell as it divides into the many diverse types of cells that make up a complex organism like a human being... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 8, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Silk and cellulose biologically effective for use in stem cell cartilage repair
Over 20 million people in Europe suffer from osteoarthritis which can lead to extensive damage to the knee and hip cartilage. Stem cells offer a promising way forward but a key challenge has been to design a ‘smart material’ that is biologically effective for cartilage tissue regeneration. Now researchers have identified a blend of naturally occurring fibres such as cellulose and silk that makes progress towards affordable and effective cell-based therapy for cartilage repair a step closer. (Source: University of Bristol news)
Source: University of Bristol news - May 8, 2013 Category: Universities & Medical Training Authors: news_text Tags: Press releases Source Type: news

Reviewing the Follow-up Care of Pediatric Patients' Status Post-Hematopoietic Stem Cell Transplantation for the Primary Care Pediatrician
Conclusion: Late adverse effects after pediatric HSCT are common and require close screening and monitoring, which can be done by the primary care provider along with the oncologist. (Source: Clinical Pediatrics)
Source: Clinical Pediatrics - May 8, 2013 Category: Pediatrics Authors: Jesudas, R., Malesky, A., Chu, R., Fischer, H., Kamat, D. Tags: Commentary Source Type: research

Defining the path to hematopoietic stem cells
Nature Biotechnology 31, 416 (2013). doi:10.1038/nbt.2571 Authors: Christopher M Sturgeon, Andrea Ditadi, Raedun L Clarke & Gordon Keller New insights into hemogenic endothelium will facilitate efforts to produce hematopoietic stem cells in vitro. (Source: Nature Biotechnology)
Source: Nature Biotechnology - May 8, 2013 Category: Biotechnology Authors: Christopher M SturgeonAndrea DitadiRaedun L ClarkeGordon Keller Tags: News and Views Source Type: research

Become an Advocate for Science: Join the AIBS Legislative Action Center
Quick, free, easy, effective, impactful! Join the AIBS Legislative Action Center today! (www.aibs.org/public-policy/legislativeactioncenter.html) The AIBS Legislative Action Center is an online resource that allows biologists and science educators to quickly and effectively influence policy and public opinion. Each day lawmakers must make tough decisions about science policy. For example, what investments to make in federal research programs, how to conserve biodiversity, how to mitigate climate change, or under what circumstances to permit stem cell research. Scientists now have the opportunity to help elected officials ...
Source: Public Policy Reports - May 7, 2013 Category: Biology Authors: AIBS Source Type: news

Stress Induces AMP-Dependent Loss of Potency Factors Id2 and Cdx2 in Early Embryos and Stem Cells
Stem Cells and Development May 2013, Vol. 22, No. 10: 1564-1575. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 7, 2013 Category: Stem Cells Tags: article Source Type: research