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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 24.

Inside this issue
See Salem et al., pages 209–218, and Wolschke et al., pages 134–142. Multiple myeloma (MM) is a rare but devastating plasma cell malignancy that affects mainly older adults. In the last ten years, induction regimens that combine the glucocorticoid-analog dexametasone (Dex) with novel chemotherapeutic agents, such as the proteasome-inhibitor bortezomib (BTZ) or the antiangiogenetic and immunomodulator drugs thalidomide and its derivative lenalidomide, have significantly increased the complete response (CR) rate before and after Allogenic Stem Cell Transplantation (ASCT) with a positive impact on progression-free sur...
Source: Experimental Hematology - January 7, 2013 Category: Hematology Tags: Inside This Issue Source Type: research

Interactions of Bone Marrow Stromal Cells with Native and RGD Surface Modified Acellular Bone Matrix: A Biocompatibility Study
This study investigated the biocompatibility of mesenchymal stem cells (MSCs) and native or surface modified ACM (RGD-ACM) scaffolds in the construction of tissue-engineered bone. Wistar rat bone marrow-derived MSCs were isolated by density gradient centrifugation for in vitro culture. MSCs were seeded on ACM with or without surface modification by RGD peptides to generate tissue-engineered bone for in vitro culture. Significantly higher adhesion of MSCs to RGD-ACM was observed compared with the native material. Detection of active alkaline phosphatase (ALP) indicated intercalation of this protein into the scaffold enhan...
Source: Archives of Medical Research - January 7, 2013 Category: Research Authors: Hua-feng Zhang, Zhi-jun Li, Xin Fu, Jian-xiong Ma, Xin-long Ma Tags: Preliminary Report Source Type: research

Comparison of Mesenchymal Stem Cells (Osteoprogenitors) Harvested From Proximal Humerus and Distal Femur During Arthroscopic Surgery
Conclusions: Arthroscopic aspiration of bone marrow from the proximal humerus and distal femur is a reproducible technique and yields reliable concentrations of MSCs. The use of an intraoperative concentration method resulted in consistent amounts of MSCs in all clinically relevant age groups without a significant drop of the number of isolated MSCs.Clinical Relevance: Human MSCs derived from concentrated bone marrow aspirate are a promising biological addition that may have practical use in the future of soft tissue augmentation. Arthroscopic techniques for bone marrow aspiration that do not require an additional surgical...
Source: Arthroscopy - January 7, 2013 Category: Surgery Authors: Knut Beitzel, Mary Beth R. McCarthy, Mark P. Cote, Thomas J.S. Durant, David M. Chowaniec, Olga Solovyova, Ryan P. Russell, Robert A. Arciero, Augustus D. Mazzocca Tags: Original Articles Source Type: research

Therapeutic Potential of Fetal Mesenchymal Stem Cells.
PMID: 23317464 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Roubelakis MG Tags: Curr Stem Cell Res Ther Source Type: research

Editorial: Stem Cell Therapy and Tissue Engineering Applications for Bone.
PMID: 23317465 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Malik A, Khan WS Tags: Curr Stem Cell Res Ther Source Type: research

Biomaterials and Scaffolds in Bone and Musculoskeletal Engineering.
This article reviews biomaterials and scaffolds in orthopaedic tissue engineering and covers clinical applications of scaffolds with particular emphasis on bone and cartilage tissue engineering. PMID: 23317466 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Kosuge D, Khan WS, Haddad B, Marsh D Tags: Curr Stem Cell Res Ther Source Type: research

Clinical Advances in Bone Regeneration.
Abstract Understanding of the biology of bone regeneration has been increasing rapidly, with greater appreciation for the importance of biochemical aspects as well as the mechanical requirements for bone to heal. There are a number of situations where there is difficulty in bone healing such as fracture non-union; or growth such as osteogenesis imperfecta; or a requirement for surplus bone to reconstruct defects such as following surgery for tumour excision or limb lengthening. There is a greater understanding of the complex interplay between osteoblasts and osteoclasts, and the chemical mediators that that provid...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Siddiqui NA, Owen JM Tags: Curr Stem Cell Res Ther Source Type: research

A review of techniques for gene therapy in bone healing.
Abstract Gene therapy has been used successfully in several areas of medicine as a technique to either alter defective genes or as method to enable delivery of therapeutic proteins. Despite advances in surgical and pharmaceutical interventions for diseases of bone regeneration and healing, results in certain patient groups remain sub-optimal. With this considered, gene therapy is currently being investigated as a means of facilitating healing and improving outcomes. Two broad techniques which are currently utilised by research teams are discussed in this review; ex vivo and in vivo. The underlying principle is simi...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Tarassoli P, Khan WS, Hughes A, Heidari N Tags: Curr Stem Cell Res Ther Source Type: research

Preclinical and Clinical Studies on the Use of Stem Cells for Bone Repair: A Systematic Review.
Abstract The management of extensive bone defects in the setting of fracture repair, non-union and revision arthroplasty are challenging problems. The supply of harvestable autologous bone graft is limited, with an associated morbidity, and therefore a need exists for a better solution in large defects. The use of stem cells is an evolving field of research, with different potential applications, ranging from simple injection of cells to tissue engineering using osteogenic cells seeded onto a scaffold. This systematic review aims to collate the published preclinical and clinical studies investigating the potentia...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Ambikaipalan A, Wong JM, Khan WS Tags: Curr Stem Cell Res Ther Source Type: research

Current Strategies of Tissue Engineering in Talus Chondral Defects.
Abstract Due to the nature of articular cartilage of being poorly vascularized the capabilities of self repair are limited. Mesenchymal stem cells transplantation is a modern technique which has been developed after the high success rates obtained by microfracturing and drilling techniques which promote the release of growth factors and the infiltration of bone marrow derived cells in the lesion. In order to increase the concentration of bone marrow derived cells appropriate devices, the scaffolds, are necessary. These three dimensional constructs mimic the physiological ambient of chondrogenesis. The race for new ...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Martinelli N, Bonifacini C, Longo UG, Marinozzi A, Florio P, Khan WS, Denaro V Tags: Curr Stem Cell Res Ther Source Type: research

A systematic review of tissue engineered meniscus strategies: experimental preclinical studies.
Abstract Meniscal injuries are one of the common sports injuries and their natural healing is limited. Removal of injured meniscus alters knee biomechanics and predisposes patients to osteoarthritis. Tissue engineered meniscus provides a novel approach for the treatment of severe meniscus injury. The aim of this review is to review preclinical studies that used cell based approaches for tissue engineered meniscus. Studies were assessed for inclusion following a search in PubMed, UK PubMed central and Embase. All preclinical studies that used cell based approaches for meniscus regeneration were included in the study...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Haddad B, Pakravan AH, Konan S, Adesida A, Khan W Tags: Curr Stem Cell Res Ther Source Type: research

A systematic review of tissue engineered meniscus and replacement strategies: preclinical models.
Abstract Meniscal injuries are one of the common sports injuries and their natural healing is limited. Removal of injured meniscus impairs normal knee function and predisposes patients to osteoarthritis. Tissue engineering and replacement strategies provide a novel approach for the treatment of severe meniscus injury. The aim of this article is to review preclinical studies that used approaches for meniscal replacement including growth factors, synthetic and tissue engineered scaffolds and non-meniscal autografts. Medline, EMBASE and UK PubMed search was performed and articles were assessed for inclusion. Included ...
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Haddad B, Haddad B, Konan S, Adesida A, Khan W Tags: Curr Stem Cell Res Ther Source Type: research

A systematic review on preclinical and clinical studies on the use of scaffolds for bone repair in skeletal defects.
Conclusions: There is a lot of pre clinical evidence that the use of scaffold combined with mesenchymal stem cells enhances osteogenesis when treating bone defects. There is limited clinical evidence at this early stage that scaffolds can be used safely and effectively in tissue engineered grafts to repair bone defects with no RCTs as yet having been conducted. The limited clinical series reported have however produced promising results. PMID: 23317473 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - January 7, 2013 Category: Stem Cells Authors: Crowley C, Wong JM, Fisher D, Khan WS Tags: Curr Stem Cell Res Ther Source Type: research

Cytological, immunocytochemical, ultrastructural and growth characterization of the rainbow trout liver cell line RTL-W1.
Abstract Despite its wide use in toxicology, a detailed characterization of RTL-W1 cell line lagged behind leaving ambiguities about its cell origin. We aimed to better characterize the line regarding cell phenotype and tumorigenic state. We studied RTL-W1 cells in monolayers and in (4-22-week-old) aggregates considering: (a) morphology (light and electron microscopy); (b) immunophenotype using AE1/AE3, vimentin, Cam5.2, CK7 and CK19 and e-cadherin antibodies and (c) growth behavior. RTL-W1 organelle content is constituted basically by mitochondria and abundant free ribosomes, with no (cytochemically) detectable pe...
Source: Tissue and Cell - January 7, 2013 Category: Cytology Authors: Malhão F, Urbatzka R, Navas JM, Cruzeiro C, Monteiro RA, Rocha E Tags: Tissue Cell Source Type: research

GANT-61 inhibits pancreatic cancer stem cell growth in vitro and in NOD/SCID/IL2R gamma null mice xenograft
The objectives of this study were to examine the molecular mechanisms by which GANT-61 (Gli transcription factor inhibitor) regulates stem cell characteristics and tumor growth. Effects of GANT-61 on CSC’s viability, spheroid formation, apoptosis, DNA-binding and transcriptional activities, and epithelial–mesenchymal transition (EMT) were measured. Humanized NOD/SCID/IL2R gammanull mice were used to examine the effects of GANT-61 on CSC’s tumor growth. GANT-61 inhibited cell viability, spheroid formation, and Gli–DNA binding and transcriptional activities, and induced apoptosis by activation of caspase-3 and cleava...
Source: Cancer Letters - January 7, 2013 Category: Cancer & Oncology Authors: Junsheng Fu, Mariana Rodova, Sanjit K. Roy, Jay Sharma, Karan P. Singh, Rakesh K. Srivastava, Sharmila Shankar Tags: Research Articles Source Type: research

Delta like ligand 4 induces impaired chemo-drug delivery and enhanced chemoresistance in pancreatic cancer
Highlights: ► DLL4 positive immunoreactivity was observed in most cases of duct cells from tumor tissues. ► Chemo-drug distribution was broadly consistent with intratumoral blood perfusion. ► Defective angiogenesis caused by DLL4/Notch pathway induced the inefficient drug delivery. ► DLL4 enhanced chemoresistance through the angiogenesis dependent and independent mechanisms.Abstract: The stubborn chemoresistance of pancreatic ductal adenocarcinoma (PDA) is simultaneously influenced by tumor parenchymal and stromal factors, and the ctritical role of Notch ligand Delta-like 4 (DLL4) in the regulation of tumor maligna...
Source: Cancer Letters - January 7, 2013 Category: Cancer & Oncology Authors: Muxing Kang, Biao Jiang, Bin Xu, Wenjie Lu, Qingqu Guo, Qiuping Xie, Bo Zhang, Xin Dong, Daniel Chen, Yulian Wu Tags: Research Articles Source Type: research

Human rhinovirus C in adult haematopoietic stem cell transplant recipients with respiratory illness
Conclusions: The newly described HRV-C was the most common rhinovirus group detected in HSCT recipients with respiratory infection, with co-pathogens being frequent. Further research is required to understand the activity and pathogenicity of this virus in HSCT recipients.
Source: Journal of Clinical Virology - January 7, 2013 Category: Virology Authors: Patricia E. Ferguson, Nicole M. Gilroy, Cassandra E. Faux, Ian M. Mackay, Theo P. Sloots, Michael D. Nissen, Dominic E. Dwyer, Tania C. Sorrell Tags: Short communications Source Type: research

Cell Migration: Cooperation between Myosin II Isoforms in Durotaxis.
Abstract A new study reveals that non-muscle myosin II plays a central role in the durotaxis of mesenchymal stem cells, with the two major isoforms, II-A and II-B, being cooperatively required for this cell movement, and serine phosphorylation of the II-A isoform playing a negative role. PMID: 23305668 [PubMed - in process]
Source: Current Biology - January 7, 2013 Category: Biology Authors: Manzanares MV Tags: Curr Biol Source Type: research

Targeting Role of Glioma Stem Cells for Gliobastoma Multiforme.
Abstract Glioblastoma multiforme (GBM) represents the most common and lethal malignant primary brain tumor. Despite vigorous basic and clinical studies over the past decades, the prognosis of patients with GBM has remained dismal. The fundamental problem with these malignancies is due to tumor cells' highly infiltrative nature, precluding a complete surgical resection, and a productive or acquired resistance to cytotoxic therapy. Recent studies demonstrated that GBMs exhibited remarkable cellular heterogeneity and hierarchy containing self-renewing glioma stem cells (GSCs). The malignant growth of GBM can be propag...
Source: Current Medicinal Chemistry - January 7, 2013 Category: Chemistry Authors: Zhang X, Zhang W, Mao XG, Zhen HN, Cao WD, Hu SJ Tags: Curr Med Chem Source Type: research

Embryonic Stem Cells Or Induced Pluripotent Stem Cells? A DNA Integrity Perspective.
Abstract Induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs) are two types of pluripotent stem cells that hold great promise for biomedical research and medical applications. iPSCs were initially favorably compared to ESCs. This view was first based on ethical arguments (the generation of iPSCs does not require the destruction of an embryo) and on immunological reasons (it is easier to derive patient HLA-matched iPSCs than ESCs). However, several reports suggest that iPSCs might be characterized by higher occurrence of epigenetic and genetic aberrations than ESCs as a consequence of the reprogram...
Source: Current Gene Therapy - January 7, 2013 Category: Genetics & Stem Cells Authors: Bai Q, Desprat R, Klein B, Lemaître JM, de Vos J Tags: Curr Gene Ther Source Type: research

Whole anterior segment proton beam radiotherapy for diffuse iris melanoma.
CONCLUSIONS: Whole anterior segment PBR is a useful alternative to enucleation for diffuse iris melanoma. Most patients will need treatment for glaucoma and some may require treatment for tear-film instability and/or stem cell failure. PMID: 23298884 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - January 7, 2013 Category: Opthalmology Authors: Konstantinidis L, Roberts D, Errington RD, Kacperek A, Damato B Tags: Br J Ophthalmol Source Type: research

New insights into the normal and leukemic stem cell niche: A timely review
Source: Cytometry Part B: Clinical Cytometry - January 7, 2013 Category: Molecular Biology Authors: Richard A. Van Etten Tags: Editorial Source Type: research

High court will not review federal stem cell funds
Source: Modern Medicine - January 7, 2013 Category: Journals (General) Source Type: news

New and updated pubs available, including Understanding Clinical Trials and Stem Cell Transplant.
Source: International Myeloma Foundation - January 7, 2013 Category: Hematology Source Type: news

Re‐emerging Philadelphia chromosome‐positive acute leukaemia more than 20 years after allogeneic haematopoietic stem cell transplantation
Source: British Journal of Haematology - January 7, 2013 Category: Hematology Authors: Yuichi Kodama, Jun Okamura, Reiji Fukano, Kentaro Nakashima, Nobuhiro Ito, Miho Nishimura, Yasunobu Abe, Takayuki Suzuki, Jiro Inagaki Tags: Correspondence Source Type: research

Leukaemia relapse after allogeneic transplants for acute myeloid leukaemia: predictive role of WT1 expression
In conclusion, WT1 expression post‐HSCT is a strong predictor of leukaemia relapse and survival in AML; WT1 may be used as a marker for early interventional therapy.
Source: British Journal of Haematology - January 7, 2013 Category: Hematology Authors: Sarah Pozzi, Simona Geroldi, Elisabetta Tedone, Silvia Luchetti, Raffaella Grasso, Nicoletta Colombo, Carmen Di Grazia, Teresa Lamparelli, Francesca Gualandi, Adalberto Ibatici, Stefania Bregante, Maria Teresa Lint, Anna Maria Raiola, Alida Dominietto, Ri Tags: Research Paper Source Type: research

Light chain amyloidosis 2012: a new era
Summary AL amyloidosis patients with multi‐organ and particularly cardiac involvement have historically been considered to have a bad prognosis. The introduction of autologous stem cell transplantation was associated with unacceptable toxicity in high‐risk patients, but responding patients have prolonged overall survival. Toxicities can be decreased by careful patient selection, but this reduces the applicability of this treatment modality to a limited number of patients. Efforts are therefore needed to design novel more effective regimens, with the use of new medications, such as thalidomide, lenalidomide and bortezom...
Source: British Journal of Haematology - January 7, 2013 Category: Hematology Authors: Moshe E. Gatt, Giovanni Palladini Tags: Review Source Type: research

MLL‐rearranged acute lymphoblastic leukaemia stem cell interactions with bone marrow stroma promote survival and therapeutic resistance that can be overcome with CXCR4 antagonism
Summary Infants with MLL‐rearranged (MLL‐R) acute lymphoblastic leukaemia (ALL) have a dismal prognosis. While most patients achieve remission, approximately half of patients recur with a short latency to relapse. This suggests that chemotherapy‐resistant leukaemia stem cells (LSCs) survive and can recapitulate the leukaemia. We hypothesized that interactions between LSCs and the bone marrow microenvironment mediate survival and chemotherapy resistance in MLL‐R ALL. Using primary samples of infant MLL‐R ALL, we studied the influence of bone marrow stroma on apoptosis, proliferation, and cytotoxicity induced by th...
Source: British Journal of Haematology - January 7, 2013 Category: Hematology Authors: Edward Allan R. Sison, Rachel E. Rau, Emily McIntyre, Li Li, Donald Small, Patrick Brown Tags: Research Paper Source Type: research

Risk‐stratified adoptive cellular therapy following allogeneic hematopoietic stem cell transplantation for advanced chronic lymphocytic leukaemia
In conclusion, the directed delivery of allogeneic cellular therapy has the potential to induce durable remissions in high‐risk CLL without incurring excessive GVHD.
Source: British Journal of Haematology - January 7, 2013 Category: Hematology Authors: Simon E. Richardson, Iftekhar Khan, Andrew Rawstron, Jagoda Sudak, Noha Edwards, Stephanie Verfuerth, Adele K. Fielding, Anthony Goldstone, Panagiotis Kottaridis, Emma Morris, Reuben Benjamin, Karl S. Peggs, Kirsty J. Thomson, Elisabeth Vandenberghe, Step Tags: research paper Source Type: research

Randomized Phase II Study of Bortezomib, Thalidomide, and Dexamethasone With or Without Cyclophosphamide As Induction Therapy in Previously Untreated Multiple Myeloma [Hematologic Malignancies]
Conclusion Both VTD and VTDC are highly active induction regimens producing high combined CR/nCR and MRD-negative rates; however, VTDC was associated with increased toxicity and suggestion of transient decreases in Global Health score, without an increase in activity.
Source: Journal of Clinical Oncology - January 7, 2013 Category: Cancer & Oncology Authors: Ludwig, Viterbo, Greil, Masszi, Spicka, Shpilberg, Hajek, Dmoszynska, Paiva, Vidriales, Esteves, Stoppa, Robinson, Ricci, Cakana, Enny, Feng, van de Velde, Harousseau Tags: Combined Modality, Biological Therapy Hematologic Malignancies Source Type: research

Platelet‐derived growth factor‐BB accelerates prostate cancer growth by promoting the proliferation of mesenchymal stem cells
In this study, we first found that MSCs promoted prostate cancer (PCa) tumor growth in vivo and cell proliferation in vitro by using PCs cell strain RM‐1. Both exogenous and endogenous MSCs could be recruited into the tumor microenvironment by using bone‐marrow transplantation model. We further demonstrated that PDGF‐BB produced by RM‐1 cell promoted MSCs proliferation in vivo and in vitro, which was abrogated by Si‐RNA specific to PDGF‐BB. And inflammatory cytokines, such as interferon gamma, tumor necrosis factor alpha and anti‐inflammatory cytokine transformation growth factor alpha, further increased the ...
Source: Journal of Cellular Biochemistry - January 7, 2013 Category: Biochemistry Authors: Jiwen Cheng, Huama Ye, Zhiyong Liu, Chuanliang xu, Zhensheng Zhang, Yan Liu, Yinghao Sun Tags: Article Source Type: research

Long interspersed nucleotide element‐1 hypomethylation in folate‐deficient mouse embryonic stem cells
This study provides preliminary evidence of folate deficiency affecting early embryonic development. J. Cell. Biochem. © 2013 Wiley Periodicals, Inc.
Source: Journal of Cellular Biochemistry - January 7, 2013 Category: Biochemistry Authors: Shaoyan Chang, Li Wang, Yunqian Guan, Shaofang Shangguan, Qingan Du, Yang Wang, Ting Zhang, Yu Zhang Tags: Article Source Type: research

Differentiated umbilical cord matrix stem cells as a new in vitro model to study early events during hepatitis B virus infection
Conclusion: UCMSCs become supportive of the entire HBV life cycle upon in vitro hepatic differentiation. Despite low replication efficiency, D‐UCMSCs proved to be fully capable of HBV uptake. Overall, UCMSCs are a unique human, easily available, nontransformed, in vitro model of HBV infection that could prove useful to study early infection events and the role of the cell differentiation state on such events. (HEPATOLOGY 2013)
Source: Hepatology - January 7, 2013 Category: Internal Medicine Authors: Massimiliano Paganelli, Kai Dallmeier, Omar Nyabi, Isabelle Scheers, Benoît Kabamba, Johan Neyts, Patrick Goubau, Mustapha Najimi, Etienne M. Sokal Tags: Viral Hepatitis Source Type: research

Feather regeneration as a model for organogenesis
In the process of organogenesis, different cell types form organized tissues and tissues are integrated into an organ. Most organs form in the developmental stage, but new organs can also form in physiological states or following injuries during adulthood. Feathers are a good model to study post‐natal organogenesis because they regenerate episodically under physiological conditions and in response to injuries such as plucking. Epidermal stem cells in the collar can respond to activation signals. Dermal papilla located at the follicle base controls the regenerative process. Adhesion molecules (e.g., neural cell adhesion m...
Source: Development, Growth and Differentiation - January 7, 2013 Category: Research Authors: Sung‐Jan Lin, Randall B. Wideliz, Zhicao Yue, Ang Li, Xiaoshan Wu, Ting‐Xin Jiang, Ping Wu, Cheng‐Ming Chuong Tags: Review Article Source Type: research

Bladder cancer genetic variant identified
Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many prostate and pancreatic tumors, say researchers from the National Cancer Institute, Bethesda, MD.
Source: Modern Medicine - January 7, 2013 Category: Journals (General) Source Type: news

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine
Nature Medicine 19, 35 (2013). doi:10.1038/nm.3028 Authors: Paolo Bianco, Xu Cao, Paul S Frenette, Jeremy J Mao, Pamela G Robey, Paul J Simmons & Cun-Yu Wang
Source: Nature Medicine - January 7, 2013 Category: Journals (General) Authors: Paolo BiancoXu CaoPaul S FrenetteJeremy J MaoPamela G RobeyPaul J SimmonsCun-Yu Wang Tags: Perspective Source Type: research

High targeted migration of human mesenchymal stem cells grown in hypoxia is associated with enhanced activation of RhoA
Conclusions: The results of this study indicate that high directional migration of hMSCs permanently grown in hypoxia is associated with the enhanced activation of RhoA. The enhanced migratory capacity of hypoxic hMSC would further suggest their potential advantages for clinical applications.
Source: BioMed Central - January 7, 2013 Category: Journals (General) Authors: Grigory VertelovLudmila KharaziMg MuralidharGivon SanatiTimothy TankovichAlex Kharazi Source Type: research

Intermediate-dose Ara-C plus G-CSF for stem cell mobilization in patients with lymphoid malignancies, including predicted poor mobilizers
rus, A Smagur & J Holowiecki
Source: Bone Marrow Transplantation - January 7, 2013 Category: Hematology Authors: S GiebelT KruzelT CzerwM Sadus-WojciechowskaJ NajdaE ChmielowskaS GrosickiA JurczyszynM PasiarskiE NowaraM Glowala-KosinkaA ChwiedukI MitrusA SmagurJ Holowiecki Tags: SCT mobilization Ara-C CY Source Type: research

Response to pretransplant hypomethylating agents influences the outcome of allogeneic hematopoietic stem cell transplantation in adults with myelodysplastic syndromes
This study describes a retrospective analysis on the transplant outcome of 56 consecutive patients with myelodysplastic syndrome (MDS) according to their response to hypomethylating agents (HMA). While 2‐yr disease‐free survival (DFS) of patients who transformed to acute myeloid leukemia (n = 12) was 25%, that of the remaining patients with MDS according to response to HMA was 73.1%, 68.1%, 50.0%, and 20.8% in G‐COR (group of continuous response, n = 19), G‐NoC (group of no change, n = 15), G‐LOR (group of loss of response, n = 6), and G‐DP (group of disease progression, n = 4), respectively. When dic...
Source: European Journal of Haematology - January 7, 2013 Category: Hematology Authors: Seung‐Ah Yahng, Jae‐Ho Yoon, Seung‐Hwan Shin, Sung‐Eun Lee, Byung‐Sik Cho, Dong‐Gun Lee, Ki‐Seong Eom, Seok Lee, Chang‐Ki Min, Hee‐Je Kim, Seok‐Goo Cho, Dong‐Wook Kim, Jong‐Wook Lee, Woo‐Sung Min, Tai‐Gyu Kim, Chong‐Won Park, Tags: Original Article Source Type: research

'Behind the Headlines' assessment of press reports that 'turbocharged' immune cells may be key to cancer cure
Source: NHS Choices Area: News The 'Behind the Headlines' service from NHS Choices has featured a quality assessment of press reports that scientists have created an injection that can target cancer cells (reported by BBC News, Daily Mail and Daily Express, 3rd January 2013). The NHS Choices assessment looks at the research that these reports were based on - two similar studies in which researchers used stem cells to clone and produce large numbers of cytotoxic T lymphocytes. The author states that this research could be an important step in paving the way towards future immunotherapy treatment for some c...
Source: NeLM - News - January 7, 2013 Category: Drugs & Pharmacology Source Type: news

One Goal, Different Strategies ‐ Molecular and Cellular Approaches for the Treatment of Inherited Skin Fragility Disorders
Abstract Epidermolysis bullosa (EB) is a heterogeneous group of inherited diseases characterized by the formation of blisters in the skin and mucosa. There is no cure or effective treatment for this potentially severe and fatal disease. Over the past few years, several reports have proposed different molecular strategies as new therapeutic options for the management of EB. From classical vector‐based gene therapy to cell‐based strategies such as systemic application of bone marrow stem cells or local application of fibroblasts, a broad range of molecular approaches have been explored. This array also includes novel met...
Source: Experimental Dermatology - January 7, 2013 Category: Dermatology Authors: Christian Hünefeld, Markus Mezger, Johannes S. Kern, Alexander Nyström, Leena Bruckner‐Tuderman, Ingo Müller, Rupert Handgretinger, Martin Röcken Tags: Review Article Source Type: research

Repigmentation of Poliosis After Epithelial Grafting for Vitiligo
ConclusionRe‐coloring of poliosis with vitiligo is possible but was unexpected because of the difference in mechanism and signaling required between hair bulb melanization and the surface skin. One likely mechanism to explain this change is that melanocyte stem cells are stimulated and migrate to supply hair bulbs with new mature melanocytes. Epithelial grafting of vitiligo with poliosis in hairy areas should be a treatment of choice when white hair tufts cause cosmetic disfigurement.
Source: Dermatologic Surgery - January 7, 2013 Category: Dermatology Authors: Sherif S. Awad Tags: Original Article Source Type: research

Ovarian cancer stem cell study puts targeted therapies within reach
(Yale University) Researchers at Yale School of Medicine have identified a key link between stem cell factors that fuel ovarian cancer's growth and patient prognosis. The study, which paves the way for developing novel targeted ovarian cancer therapies, is published online in the current issue of Cell Cycle.
Source: EurekAlert! - Biology - January 7, 2013 Category: Biology Source Type: news

Small molecule-based approaches to adult stem cell therapies.
Abstract There is considerable interest in the development of stem cell-based strategies for the treatment of a broad range of human diseases, including neurodegenerative, autoimmune, cardiovascular, and musculoskeletal diseases. To date, such regenerative approaches have focused largely on the development of cell transplantation therapies using cells derived from pluripotent embryonic stem cells (ESCs). Although there have been exciting preliminary reports describing the efficacy of ESC-derived replacement therapies, approaches involving ex vivo manipulated ESCs are hindered by issues of mutation, immune rejection...
Source: Annual Review of Pharmacology and Toxicology - January 6, 2013 Category: Drugs & Pharmacology Authors: Lairson LL, Lyssiotis CA, Zhu S, Schultz PG Tags: Annu Rev Pharmacol Toxicol Source Type: research

Pluripotent stem cell-derived hepatocytes: potential and challenges in pharmacology.
Abstract The liver is a fascinating organ and performs a wide range of functions necessary for life. Because the hepatocyte is the major functional cell type found in the liver, it is important that we better understand its role in health and disease. Functional hepatocytes have been derived from many sources, including human stem cell populations. These models offer new opportunities to further our understanding of human liver biology from diverse genotypes and, in the future, to facilitate the development of novel medicines or cell-based therapies. This review discusses limitations in current cell-based models an...
Source: Annual Review of Pharmacology and Toxicology - January 6, 2013 Category: Drugs & Pharmacology Authors: Szkolnicka D, Zhou W, Lucendo-Villarin B, Hay DC Tags: Annu Rev Pharmacol Toxicol Source Type: research

Neurogenic and neuro-protective potential of a novel subpopulation of peripheral blood-derived CD133+ ABCG2+CXCR4+ mesenchymal stem cells: development of autologous cell based therapeutics for traumatic brain injury
A population of mesenchymal stem cells which can be reliably isolated from peripheral blood have potential for the treatment of traumatic brain injury and neurodegenerative disorders.
Source: BioMed Central - January 6, 2013 Category: Journals (General) Authors: Joan E NicholsJean A NilesDouglas DeWittDonald ProughMargaret ParsleyStephanie VegaAndrea CantuEric LeeJoaquin Cortiella Source Type: research

A Hierarchy in Reprogramming Capacity in Different Tissue Microenvironments: What We Know and What We Need to Know
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 5, 2013 Category: Stem Cells Tags: article Source Type: research

Inside the meat lab: the future of food
With billions of mouths to feed, we can't go on producing food in the traditional way. Scientists are coming up with novel ways to cater for future generations. In-vitro burger, anyone?The future feast is laid out around a cool white room at Eindhoven's University of Technology . There is a steak tartare of in-vitro beef fibre, wittily knitted into the word "meat". There are "fruit-meat" amuse-gueules. The green- and pink-striped sushi comes from a genetically modified vegetarian fish called the biccio that, usefully, has green- and pink-striped flesh. To wash this down, there's a programmable red wine: with a microwave pu...
Source: Guardian Unlimited Science - January 5, 2013 Category: Science Authors: Alex Renton Tags: Food security & drink Society Features Life and style The Observer Food science Source Type: news

Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.
In this study, we discuss the role of different types of immune cells involved in T1DM pathogenesis and their therapeutic potential as targets and/or modified tools to treat patients. Recently, encouraging results and new approaches to sustain remnant β cell mass and to increase β cell proliferation by different cell-based means have emerged. Results coming from ongoing clinical trials employing cell therapy designed to arrest T1DM will probably proliferate in the next few years. Strategies under consideration include infusion of several types of stem cells, dendritic cells and regulatory T cells, either manipulated gene...
Source: Clinical and Developmental Immunology - January 5, 2013 Category: Allergy & Immunology Authors: Barcala Tabarrozzi AE, Castro CN, Dewey RA, Sogayar MC, Labriola L, Perone MJ Tags: Clin Exp Immunol Source Type: research

Cancer-Killing Stem Cells Could Be Used To Treat Cancer
Researchers in Japan have for the first time shown it is possible to make cancer-specific immune system cells from induced pluripotent stem cells (iPSCs). Their work brings closer the day when therapies use cloned versions of patients' own cells to boost their immune system's natural ability to kill cancer cells. The researchers, from the RIKEN Research Centre for Allergy and Immunology in Yokohama, describe how they created cancer-specific killer T lymphocytes from iPSCs, in a paper published online on 3 January in the journal Cell Stem Cell...
Source: Health News from Medical News Today - January 5, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news