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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 15.

Stem cell agency not doing enough to avoid conflict of interest
The California agency's board is wrestling with recommendations for changes in its membership and its authority over the spending of its $3-billion endowment.Compromise, defined as the art of getting part of a loaf when the whole loaf is out of reach, comes in many forms. But surely the strangest of all is what comes of trying to compromise with yourself.
Source: Los Angeles Times - Science - January 29, 2013 Category: Science Source Type: news

ALDH1 expression predicts outcome in node-negative rectal cancer
Expression of the cancer stem cell marker aldehyde dehydrogenase 1 is an independent predictor for poor prognosis in node-negative rectal cancer, researchers say.
Source: MedWire News - Gastroenterology - January 29, 2013 Category: Gastroenterology Source Type: news

Become an Advocate for Science: Join the AIBS Legislative Action Center
Quick, free, easy, effective, impactful! Join the AIBS Legislative Action Center today! (www.aibs.org/public-policy/legislativeactioncenter.html) The AIBS Legislative Action Center is an online resource that allows biologists and science educators to quickly and effectively influence policy and public opinion. Each day lawmakers must make tough decisions about science policy. For example, what investments to make in federal research programs, how to conserve biodiversity, how to mitigate climate change, or under what circumstances to permit stem cell research. Scientists now have the opportunity to help elected officials u...
Source: Public Policy Reports - January 29, 2013 Category: Biology Authors: AIBS Source Type: news

Mesenchymal-to-Epithelial Transition Contributes to Endometrial Regeneration Following Natural and Artificial Decidualization
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 29, 2013 Category: Stem Cells Tags: article Source Type: research

An Adipoinductive Role of Inflammation in Adipose Tissue Engineering: Key Factors in the Early Development of Engineered Soft Tissues
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 29, 2013 Category: Stem Cells Tags: article Source Type: research

An Adipoinductive Role of Inflammation in Adipose Tissue Engineering: Key Factors in the Early Events of Neo-Adipogenesis
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 29, 2013 Category: Stem Cells Tags: article Source Type: research

BUSM Study Shows Potential Of Differentiated IPS Cells In Cell Therapy Without Immune Rejection
A new study from Boston University School of Medicine (BUSM) shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. The study, published online in Cell Stem Cell, demonstrates the potential of utilizing iPS cells to develop cell types that could offer treatment for a wide range of conditions, including diabetes, liver and lung diseases, without the barrier of immune rejection...
Source: Health News from Medical News Today - January 29, 2013 Category: Consumer Health News Tags: Biology / Biochemistry Source Type: news

First Stroke Patients In Florida Treated In UM Stem Cell Trial
The first two stroke patients have been enrolled in a phase 2 clinical trial of a revolutionary new treatment for ischemic stroke being conducted at the University of Miami/Jackson Memorial Hospital. The trial, using a patient's own bone marrow stem cells, is the first intra-arterial stroke stem cell trial in the U.S., and the two UM/Jackson patients are the first in Florida to participate. Led by Dileep Yavagal, M.D...
Source: Health News from Medical News Today - January 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

The Potential Of Differentiated IPS Cells In Cell Therapy Without Immune Rejection
A new study from Boston University School of Medicine (BUSM) shows that tissues derived from induced pluripotent stem (iPS) cells in an experimental model were not rejected when transplanted back into genetically identical recipients. The study, published online in Cell Stem Cell, demonstrates the potential of utilizing iPS cells to develop cell types that could offer treatment for a wide range of conditions, including diabetes, liver and lung diseases, without the barrier of immune rejection...
Source: Health News from Medical News Today - January 29, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

The jelly that can mend your wobbly knees
Doctors are using a type of jelly made from stem cells to treat arthritic knees. The stem cells appear to trigger the repair and re-growth of damaged cartilage.
Source: the Mail online | Health - January 29, 2013 Category: Consumer Health News Source Type: news

Prognostic impact of allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia patients with internal tandem duplication of FLT3
We examined 122 AML patients; 34 patients had FLT3-ITD and 39 patients received allogeneic HSCT. The median overall survival (OS) of patients with wtFLT3/nonHSCT, wtFLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 40.7 months, 53.4 months, 9.8 months and not reached, respectively (p=0.006). Compared to the wtFLT3/nonHSCT patients, the hazard ratio (95% CI) of OS for wtFLT3/HSCT, FLT3-ITD/nonHSCT and FLT3-ITD/HSCT was 1.39 (0.61–3.18), 3.57 (1.58–8.10) and 0.40 (0.11–1.59), respectively, after adjustment of age, sex, WBC, LDH, karyotype, NPM, and FAB classification. This result indicated that patients with FLT3-ITD/n...
Source: Leukemia Research - January 29, 2013 Category: Hematology Authors: Po-Han Lin, Ching-Chan Lin, Hwai-I Yang, Long-Yuan Li, Li-Yuan Bai, Chang-Fang Chiu, Yu-Min Liao, Chen-Yuan Lin, Ching-Yun Hsieh, Chien-Yu Lin, Cheng-Mao Ho, Shu-Fen Yang, Ching-Tien Peng, Fuu-Jen Tsai, Su-Peng Yeh Tags: Clinical Studies Source Type: research

Transplants Don't Boost Overall Survival in High-Risk DLBCL
ATLANTA (IMNG) - In young patients with high-risk diffuse large B-cell lymphoma, autologous stem cell transplantation can push the rate of progression-free survival beyond that achievable with rituximab...
Source: OncologySTAT Latest News - January 29, 2013 Category: Cancer & Oncology Source Type: news

Human adipose-derived mesenchymal stem cells engineered to secrete IL-10 inhibit APC function and limit CNS autoimmunity.
Abstract Interleukin (IL)-10 is an important immunoregulatory cytokine shown to impact inflammatory processes as manifested in patients with multiple sclerosis (MS) and in its animal model, experimental autoimmune encephalomyelitis (EAE). Several lines of evidence indicate that the effectiveness of IL-10-based therapies may be dependent on the timing and mode of delivery. In the present study we engineered the expression of IL-10 in human adipose-derived mesenchymal stem cells (Adi-IL-10-MSCs) and transplanted these cells early in the disease course to mice with EAE. Adi-IL-10-MSCs transplanted via the intraperiton...
Source: Brain, Behavior, and Immunity - January 29, 2013 Category: Neurology Authors: Payne NL, Sun G, McDonald C, Moussa L, Emerson-Webber A, Loisel-Meyer S, Medin JA, Siatskas C, Bernard CC Tags: Brain Behav Immun Source Type: research

Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects.
Abstract Neural tube defects (NTDs) are severe, common birth defects that result from failure of neural tube closure, but their pathological mechanisms are not yet fully understood. Histone modifications have an important role in gene regulation during fetal development. We therefore hypothesized that the human NTDs may be partly caused by an imbalance in metabolism, perhaps caused by nutritional deficiencies, that leads to aberrant histone modifications. Here, we report a screen of fetal brain histone modifications using 2D nano-LC strong cation exchange reverse phase (SCX/RP) MS/MS and the identification of 61 un...
Source: Neurobiology of Disease - January 29, 2013 Category: Neurology Authors: Zhang Q, Xue P, Li H, Bao Y, Wu L, Chang S, Niu B, Yang F, Zhang T Tags: Neurobiol Dis Source Type: research

Immature DC isolated after co-culture with PUVA-treated peripheral blood mononuclear cells downregulate graft-versus-host reactions in the human skin explant model.
Abstract Graft-versus-host disease (GvHD) remains the major barrier to successful allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal photopheresis (ECP) is a potent immunomodulatory treatment option for GvHD. In contrast to conventional immunosuppressants, ECP is considered not to increase relapse and infection rates resulting from generalised immunosuppression. ECP involves the mechanical separation of 5-10% of patient peripheral blood mononuclear cells, which are then exposed to psoralen and UVA light (PUVA) before they are returned to the patient. ECP has been shown to induce apoptosis i...
Source: Current Stem Cell Research and Therapy - January 29, 2013 Category: Stem Cells Authors: Holtick U, Wang XN, Marshall SR, Scheid C, von Bergwelt-Baildon M, Dickinson AM Tags: Curr Stem Cell Res Ther Source Type: research

Injection Time-Dependent Effect of Adult Human Bone Marrow Stromal Cell Transplantation in a Rat Model of Severe Traumatic Brain Injury.
Abstract The object of this study is to evaluate the effects of injecting adult human bone marrow stromal cells (hBMSCs) into rats with severe traumatic brain injury in acute phase and to determine more optimal injection timing between day 1 and day 2 postinjury. The lateral fluid percussion injury model was used. Adult hBMSCs were transplanted into hemisphere to injury sites in the corpus callosum ipsilateral on day 1 (n = 12) or day 7 (n = 8) after injury. A control group (n = 7) underwent only a sham operation without stem cell transplantation. Rats in all groups were analyzed by magnetic resonance spectroscopy ...
Source: Current Stem Cell Research and Therapy - January 29, 2013 Category: Stem Cells Authors: Han EY, Chun MH, Kim ST, Lim DP Tags: Curr Stem Cell Res Ther Source Type: research

Cedars-Sinai Heart Institute study: Stem cells boost heart's natural repair mechanisms
(Cedars-Sinai Medical Center) Researchers at the Cedars-Sinai Heart Institute, whose clinical trial results in 2012 demonstrated that stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack, now have found that the stem cell technique boosts production of existing adult heart cells (cardiomyocytes) and spurs recruitment of existing stem cells that mature into heart cells.
Source: EurekAlert! - Medicine and Health - January 29, 2013 Category: Global & Universal Source Type: news

Chronic exposure of astrocytes to interferon-{alpha} reveals molecular changes related to Aicardi-Goutieres syndrome
Aicardi–Goutières syndrome is a genetically determined infantile encephalopathy, manifesting as progressive microcephaly, psychomotor retardation, and in ~25% of patients, death in early childhood. Aicardi–Goutières syndrome is caused by mutations in any of the genes encoding TREX1, RNASEH2-A, -B, -C and SAMHD1, with protein dysfunction hypothesized to result in the accumulation of nucleic acids within the cell, thus triggering an autoinflammatory response with increased interferon-α production. Astrocytes have been identified as a major source of interferon-α production in the brains ...
Source: Brain - January 29, 2013 Category: Neurology Authors: Cuadrado, E., Jansen, M. H., Anink, J., De Filippis, L., Vescovi, A. L., Watts, C., Aronica, E., Hol, E. M., Kuijpers, T. W. Tags: Original Articles Source Type: research

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice: Pim kinase regulates hematopoiesis
Conclusions: Pim kinases are not only essential in the hematopoietic lineage cell development, but also important in HSC expansion, self-renewal, and long-term repopulation.
Source: Journal of Hematology and Oncology - January 29, 2013 Category: Hematology Authors: Ningfei AnAndrew KraftYubin Kang Source Type: research

A CD19/Fc fusion protein for detection of anti-CD19 chimeric antigen receptors
Conclusions: This fusion molecule is a sensitive reagent for detection of anti-CD19 CAR derived from any monoclonal antibody present in CAR-modified T-cells.
Source: Journal of Translational Medicine - January 29, 2013 Category: Research Authors: Satiro De OliveiraJiexin WangChristine RyanSherie MorrisonDonald KohnRoger Hollis Source Type: research

Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus
Conclusions: This study provides a comprehensive methylation profile of FXS and helps refine our understanding of the mechanisms behind FMR1 silencing.
Source: BioMed Central - January 29, 2013 Category: Journals (General) Authors: Reid S AlischTao WangPankaj ChopraJeannie VisootsakKaren N ConneelyStephen T Warren Source Type: research

With Senator Harkin's Retirement, NIH Loses a Champion
Iowa senator boosted biomedical research funding, stem cell research
Source: ScienceNOW - January 28, 2013 Category: Science Source Type: news

Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three-dimensional skin equivalent model in vitro: implications for regenerative therapy of canine epidermis.
Conclusions and clinical importance - A bulge stem cell-enriched population from canine hair follicles formed interfollicular epidermis within 2 weeks in vitro, and thus represents a promising model for regenerative therapy of canine skin. PMID: 23331683 [PubMed - in process]
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Kobayashi T, Enomoto K, Wang YH, Yoon JS, Okamura R, Ide K, Ohyama M, Nishiyama T, Iwasaki T, Nishifuji K Tags: Vet Dermatol Source Type: research

Stem cell therapy in veterinary dermatology.
Abstract Background - Adult stem cells come from many sources and have the capacity to differentiate into many cell types, including those of the skin. The most commonly studied stem cells are those termed mesenchymal stem cells (MSCs), which are easily isolated from bone marrow and adipose tissue. Mesenchymal stem cells are known to produce a wide array of cytokines that modulate the regeneration process. The ease of collection, propagation and use of these MSCs in therapy of traumatic, ischaemic and immune-mediated skin conditions is emerging. Approach and evidence - In traumatic and ischaemic skin damage, ...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Harman RJ Tags: Vet Dermatol Source Type: research

The contribution of stem cells to epidermal and hair follicle tumours in the dog.
Conclusions and clinical importance - Our results show that K15 can be a reliable marker for investigating the role of stem cells in hair follicle tumours of the dog, while nestin was judged to be a nonoptimal marker. Furthermore, our study suggests that hair follicle stem cells are present in the bulge region of hair follicles and could possibly play a role in tumourigenesis of canine tumours originating from this portion of the follicle, namely trichoblastomas, tricholemmomas and trichoepitheliomas. The loss of K15 expression in squamous cell carcinomas compared with normal skin suggests that this event could be impor...
Source: Veterinary Dermatology - January 28, 2013 Category: Veterinary Research Authors: Brachelente C, Porcellato I, Sforna M, Lepri E, Mechelli L, Bongiovanni L Tags: Vet Dermatol Source Type: research

BrainStorm Cell Therapeutics Appoints Alon Natanson as Chief Executive Officer
NEW YORK & PETACH TIKVAH, Israel--(Healthcare Sales & Marketing Network)--BrainStorm Cell Therapeutics (BCLI), a leading developer of adult stem cell technologies for neurodegenerative diseases, announced today that it has appointed Mr. Alon Natanson as it... Regenerative Medicine, Neurology, PersonnelBrainStorm Cell Therapeutics, stem cell
Source: HSMN NewsFeed - January 28, 2013 Category: Pharmaceuticals Source Type: news

The Action of all-trans-Retinoic Acid (ATRA) and Synthetic Retinoid Analogues (EC19 and EC23) on Human Pluripotent Stem Cells Differentiation Investigated using Single Cell Infrared Microspectroscopy
, 2013, Accepted ManuscriptDOI: 10.1039/C3MB25505K, PaperGraeme Clemens, Kevin Flower, Andrew P Henderson, Andrew Whiting, Stefan A Przyborski, Melody Jimenez-Hernandez, Paul Bassan, Francis Ball, Gianfelice Cinque, Peter GardnerAll trans-retinoic acid (ATRA) is widely used to direct the differentiation of cultured stem cells. When exposed to the pluripotent human embryonal carcinoma (EC) stem cell line, TERA2.cl.SP12, ATRA induces...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Mol. BioSyst. latest articles - January 28, 2013 Category: Molecular Biology Authors: Graeme Clemens Source Type: research

Cord Blood Bank to Improve Security After LapseCord Blood Bank to Improve Security After Lapse
California-based CBR Systems Inc, which stores stem cells from umbilical cord blood, has settled charges that poor data protection policies led to the exposure of hundreds of thousands of clients' Social Security numbers and financial data, the Federal Trade Commission said on Monday. Reuters Health Information
Source: Medscape Medical News Headlines - January 28, 2013 Category: Consumer Health News Tags: Pathology & Lab Medicine News Source Type: news

Cardio Notes: Dissolving Stent Seems to Be Safe
(MedPage Today) -- An investigational absorbable coronary stent is progressing steadily through its clinical trial. Also this week, stem cells to avoid limb amputation and a superficial femoral artery stent with a low fracture rate.
Source: MedPage Today Cardiovascular - January 28, 2013 Category: Cardiology Source Type: news

Skin Cells From Patients With Inherited Heart Condition Recreate The Adult-Onset Disease
Most patients with an inherited heart condition known as arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) don't know they have a problem until they're in their early 20s. The lack of symptoms at younger ages makes it very difficult for researchers to study how ARVD/C evolves or to develop treatments. A new stem cell-based technology created by 2012 Nobel Prize winner Shinya Yamanaka, M.D., Ph.D., helps solve this problem. With this technology, researchers can generate heart muscle cells from a patient's own skin cells...
Source: Health News from Medical News Today - January 28, 2013 Category: Consumer Health News Tags: Heart Disease Source Type: news

Stroke Recovery Aided By Stem Cells
Stem cells from bone marrow or fat improve recovery after stroke in rats, finds a study published in BioMed Central's open access journal Stem Cell Research & Therapy. Treatment with stem cells improved the amount of brain and nerve repair and the ability of the animals to complete behavioural tasks. Stem cell therapy holds promise for patients but there are many questions which need to be answered, regarding treatment protocols and which cell types to use. This research attempts to address some of these questions...
Source: Health News from Medical News Today - January 28, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

Paroxetine up-regulates neurogenesis in hippocampus-derived neural stem cell from fetal rats.
In conclusion, these data indicate that paroxetine can promote neurogenesis of neural stem cells, and this effect might be mediated by ERK1/2 signal pathways. PMID: 23291919 [PubMed - in process]
Source: Molecular and Cellular Biochemistry - January 28, 2013 Category: Biochemistry Authors: Peng ZW, Xue F, Wang HN, Zhang RG, Chen YC, Wang Y, Zhang LY, Fan J, Tan QR Tags: Mol Cell Biochem Source Type: research

The potential use of mesenchymal stem cells in hematopoietic stem cell transplantation.
Abstract In the last 10 years, mesenchymal stem cells (MSCs) have emerged as a therapeutic approach to regenerative medicine, cancer, autoimmune diseases, and many more due to their potential to differentiate into various tissues, to repair damaged tissues and organs, and also for their immunomodulatory properties. Findings in vitro and in vivo have demonstrated immune regulatory function of MSCs and have facilitated their application in clinical trials, such as those of autoimmune diseases and chronic inflammatory diseases. There has been an increasing interest in the role of MSCs in allogeneic hematopoietic stem ...
Source: exp Mol Med - January 28, 2013 Category: Molecular Biology Authors: Kim EJ, Kim N, Cho SG Tags: Exp Mol Med Source Type: research

Regulation of osteogenic differentiation of human adipose-derived stem cells by controlling electromagnetic field conditions.
This study provides a framework for future work on controlling stem cell differentiation. PMID: 23306704 [PubMed - in process]
Source: exp Mol Med - January 28, 2013 Category: Molecular Biology Authors: Kang KS, Hong JM, Kang JA, Rhie JW, Jeong YH, Cho DW Tags: Exp Mol Med Source Type: research

Restoring stem cell mobilization to promote vascular repair in diabetes.
Abstract Diabetes triggers endothelial dysfunction, which is linked to increased risk of cardiovascular diseases. Stem and progenitors cells from the bone marrow are involved in the maintenance of vascular integrity. Diabetic patients show a dysfunction of these cells, which might represent a novel pathophysiological mechanism of vascular disease. Specifically, stem and progenitor cells fail to egress from the bone marrow (BM) due to BM pathological alterations and unresponsiveness to mobilizing stimuli. In this review, we describe impaired stem cell mobilization in diabetes as a mechanism of failed vascular repair...
Source: Vascular Pharmacology - January 28, 2013 Category: Drugs & Pharmacology Authors: Albiero M, Avogaro A, Fadini GP Tags: Vascul Pharmacol Source Type: research

Stem cells' exodus: a journey to immortality.
Abstract Stem cell niches provide a regulatory microenvironment that retains stem cells and promotes self-renewal. Recently in Developmental Cell, Rinkevich et al. (2013) showed that cell islands (CIs) of Botryllus schlosseri, a colonial chordate, provide niches for maintaining cycling stem cells that migrate from degenerated CIs to newly formed buds. PMID: 23369706 [PubMed - in process]
Source: Developmental Cell - January 28, 2013 Category: Cytology Authors: Zhou Y, Lewallen M, Xie T Tags: Dev Cell Source Type: research

Trachea-derived dpp controls adult midgut homeostasis in Drosophila.
Abstract Homeostasis in adult tissues is maintained by resident stem cells and their progeny. Little is known about the regulation of tissue homeostasis by organ-organ interaction. Here we demonstrate that trachea-derived Decapentaplegic (Dpp), the main bone morphogenetic protein ligand in Drosophila, is essential for adult midgut homeostasis. We show that Dpp signaling is primarily activated in enterocytes (ECs). Depletion of Dpp signaling in ECs results in excess amounts of intestinal stem-cell-like cells and their progeny. Importantly, we find that Dpp is expressed specifically in tracheal cells that reach the i...
Source: Developmental Cell - January 28, 2013 Category: Cytology Authors: Li Z, Zhang Y, Han L, Shi L, Lin X Tags: Dev Cell Source Type: research

Scaffold-free cell pellet transplantations can be applied to periodontal regeneration.
This study aimed to fabricate scaffold-free periodontal ligament stem cell (PDLSC) pellets (MUCPs) and evaluate their regeneration potential. We constructed monolayer cells pellets (MCPs) by fabricating and culturing multilayered cells sheets (MUCS) and further constructed MUCPs by MUCS. Immunochemistry, scanning electron microscope, real-time PCR and Western blot analysis showed higher levels of COL-I, COL-III, fibronectin and laminin in the MUCPs. Furthermore, the massive increase in ECM secretion improved cell adhesion, migration and proliferation. Finally, upon the transplantation into the omentum sac and periodontal d...
Source: Cell Transplantation - January 28, 2013 Category: Cytology Authors: Guo W, He Y, Tang X, Chen G, Shi H, Gong K, Zhou J, Wen L, Ji Y Tags: Cell Transplant Source Type: research

Prospects for replacement of auditory neurons by stem cells.
This article is part of a Special Issue entitled "Inner Ear Development and Regeneration". PMID: 23370457 [PubMed - as supplied by publisher]
Source: Hearing Research - January 28, 2013 Category: Audiology Authors: Shi F, Edge AS Tags: Hear Res Source Type: research

Dynamic Expression of MicroRNAs during the Differentiation of Human Embryonic Stem Cells into Insulin-Producing Cells.
Abstract Human embryonic stem (hES) cells with the capacity of self-renewal and multilineage differentiation are promising sources for generation of pancreatic islet cells for cell replacement therapy in diabetes. Here we induced hES cells into insulin-producing cells (IPCs) in a stepwise process which recapitulates islet organogenesis by directing cells through the stages resembling definitive endoderm, gut-tube endoderm, pancreatic precursor and cells that express pancreatic endocrine hormones. The dynamic expression of microRNAs (miRNAs) during the differentiation was analyzed and was compared with that in the d...
Source: Gene - January 28, 2013 Category: Genetics & Stem Cells Authors: Wei R, Yang J, Liu GQ, Gao MJ, Hou WF, Zhang L, Gao HW, Liu Y, Chen GA, Hong TP Tags: Gene Source Type: research

Overcoming the response plateau in multiple myeloma: A novel bortezomib-based strategy for secondary induction and high-yield CD34+ stem cell mobilization.
CONCLUSION: Bortezomib-based secondary induction and mobilization could represent an alternative strategy for elimination of tumor burden in immunomodulatory drug-resistant patients that does not impact stem cell yield. PMID: 23357980 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - January 28, 2013 Category: Cancer & Oncology Authors: Niesvizky R, Mark TM, Ward MM, Jayabalan DS, Pearse R, Manco M, Stern J, Christos PJ, Mathews L, Shore TB, Zafar F, Pekle K, Xiang J, Ely S, Skerrett D, Chen-Kiang S, Coleman M, Lane ME Tags: Clin Cancer Res Source Type: research

Therapeutic strategies targeting cancer stem cells.
Abstract Increasing studies have demonstrated a small proportion of cancer stem cells (CSCs) exist in the cancer cell population. CSCs have powerful self-renewal capacity and tumor-initiating ability and are resistant to chemotherapy and radiation. Conventional anticancer therapies kill the rapidly proliferating bulk cancer cells but spare the relatively quiescent CSCs, which cause cancer recurrence. So it is necessary to develop therapeutic strategies acting specifically on CSCs. In recent years, studies have shown that therapeutic agents such as metformin, salinomycin, DECA-14, rapamycin, Oncostatin M (OSM), some...
Source: Cancer Biology and Therapy - January 28, 2013 Category: Cancer & Oncology Authors: Ning X, Du Y, Ben Q, Shu J, Li Z Tags: Cancer Biol Ther Source Type: research

Prostaglandin E2 Potentiates Mesenchymal Stem Cell-Induced IL-10+IFN-γ+CD4+ Regulatory T Cells To Control Transplant Arteriosclerosis.
The objective of this study is to elucidate the mechanism by which MSCs induce IL-10(+)IFN-γ(+)CD4(+) regulatory T type 1 (T(R)1)-like cells. In an MLR system using porcine PBMCs, MSC-induced IL-10(+)IFN-γ(+)CD4(+) cells, which confer resistance to allogeneic proliferation in an IL-10-dependent manner, resemble T(R)1-like cells. Both cyclooxygenase-derived PGE(2) and IDO help to induce T(R)1-like cells by MSCs. MSCs constitutively secrete PGE(2), which is augmented in allogeneic reactions. However, T(R)1-like cells were deficient in PGE(2) and 4-fold less potent than were MSCs in suppressing MLR. PGE(2) mimetic supplemen...
Source: Journal of Immunology - January 28, 2013 Category: Allergy & Immunology Authors: Hsu WT, Lin CH, Chiang BL, Jui HY, Wu KK, Lee CM Tags: J Immunol Source Type: research

Tumor necrosis factor–costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts
ConclusionTNF‐costimulated T lymphocytes from SSc patients have a propensity to secrete profibrotic cytokines, while the ability to produce IL‐10 is weakened. These results suggest that T lymphocytes in SSc support fibrosis, but might lack the capacity to resolve inflammation.
Source: Arthritis and Rheumatism - January 28, 2013 Category: Rheumatology Authors: Thomas Hügle, Steven O'Reilly, Rachel Simpson, Marina D. Kraaij, Venetia Bigley, Matthew Collin, Anja Krippner‐Heidenreich, Jacob M. van Laar Tags: Systemic Sclerosis Source Type: research

The Effect of Mesenchymal Stem Cells on Dynamic Changes of T Cell Subsets in Experimental Autoimmune Uveoretinitis
In this study, we further examined the effects of MSCs on the dynamics of T cell subsets in both eye and spleen and their cytokine production during the course of EAU. We focused on when and where the MSCs had inhibitory effects on Th1 and Th17 cells and how long the inhibitory effect lasted, so as to provide more mechanistic evidence for MSCs on the treatment of uveitis. Compared to the control group, administration of MSCs significantly decreased the production of Th1 and Th17 cytokines, while elevated the production of Th2 and Treg cytokines (IL‐10 and TGF‐b) during the entire course of EAU. Correspondingly, the dyn...
Source: Clinical and Experimental Immunology - January 28, 2013 Category: Allergy & Immunology Authors: Guangda Li, Lifei Yuan, Xinjun Ren, Hong Nian, Lei Zhang, Zhong Chao Han, Xiaorong Li, Xiaomin Zhang Tags: Original Article Source Type: research

An investigation of donor and culture parameters which influence epithelial outgrowths from cultured human cadaveric limbal explants
This study shows that an important factor correlating with growth variation is the duration of corneo‐scleral tissue in organ culture. Interestingly, donor age was not correlated with limbal explant growth. J. Cell. Physiol. © 2012 Wiley Periodicals, Inc.
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: Oliver Baylis, Paul Rooney, Francisco Figueiredo, Majlinda Lako, Sajjad Ahmad Tags: Original Research Article Source Type: research

Mesenchymal stem cells contribute to endogenous FVIII:c production
Abstract Besides the liver, it has been difficult to identify which organ(s) and/or cellular component(s) contribute significantly to the production of human FVIII:c (FVIII). Thus far, only endothelial cells have been shown to constitute a robust extrahepatic source of FVIII, possibly explaining both the diverse presence of FVIII mRNA in the body, and the observed increase in FVIII levels during liver failure. Here, we investigate whether human mesenchymal stem cells (MSC), ubiquitously present in different organs, could also contribute to FVIII production. MSC isolated from human lung, liver, brain, and bone marrow expres...
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: Chad Sanada, Chung‐Jung Kuo, Evan J. Colletti, Melisa Soland, Saloomeh Mokhtari, Mary Ann Knovich, John Owen, Esmail D. Zanjani, Christopher D. Porada, Graça Almeida‐Porada Tags: Original Research Article Source Type: research

Activation and promotion of adipose tissue‐derived mesenchymal stem cells by tumour necrosis factor‐alpha preconditioning for bone tissue engineering
This study investigated the effect of short‐term (three days) preconditioning with tumour necrosis factor‐alpha (TNF‐α) on proliferation, mobilization and differentiation of adipose tissue‐derived mesenchymal stem cells (ASCs). We demonstrated that TNF‐α pre‐conditioning increased proliferation, mobilization, and osteogenic differentiation of ASCs and up‐regulated bone morphogenetic protein‐2 (BMP‐2) protein levels. BMP‐2 silencing by siRNA partially inhibited osteogenic differentiation of ASCs induced by TNF‐α; BMP‐2 pre‐conditioning also significantly increased osteogenic differentiation of A...
Source: Journal of Cellular Physiology - January 28, 2013 Category: Cytology Authors: ZuFu Lu, GuoCheng Wang, Colin R Dunstan, YongJun Chen, William Yenn‐Ru Lu, Ben Davies, Hala Zreiqat Tags: Original Research Article Source Type: research