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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 22.
Safety of Induced Stem Cells Gets a Boost
A paper published in Nature today could dispel a cloud over the hopes of turning a patient’s own cells into perfectly matched replacement tissues. [More]
Source: Scientific American - Official RSS Feed - January 10, 2013 Category: Science Tags: Health,Health,Ethics,Biotechnology,Biotechnology,Biology,More Science Source Type: research
Therapeutic potential of mood stabilizers lithium and valproic Acid: beyond bipolar disorder.
This article reviews the various mechanisms of action of lithium and VPA gleaned from cellular and animal models of neurologic, neurodegenerative, and neuropsychiatric disorders. Clinical evidence is included when available to provide a comprehensive perspective of the field and to acknowledge some of the limitations of these treatments. First, the review describes how action at these drugs' primary targets-glycogen synthase kinase-3 for lithium and histone deacetylases for VPA-induces the transcription and expression of neurotrophic, angiogenic, and neuroprotective proteins. Cell survival signaling cascades, oxidative str...
Source: Pharmacological Reviews - January 10, 2013 Category: Drugs & Pharmacology Authors: Chiu CT, Wang Z, Hunsberger JG, Chuang DM Tags: Pharmacol Rev Source Type: research
Research Into Key Diseases Could Be Boosted By New Method Of Generating Stem Cells
Stem cell manufacturing for drug screening and treatments for diseases such as Huntington's and Parkinson's could be boosted by a new method of generating stem cells, a study suggests. Scientists have developed a family of compounds that can support the growth of human embryonic stem cells on a large scale for use in drug testing or treatments. The new materials, which are water-based gels, act as a tiny scaffold to which cells can cling as they grow. Normally cells must be grown on expensive biological surfaces that can carry pathogens and contaminate cells...
Source: Health News from Medical News Today - January 10, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news
Stem Cells May Hold Promise for Lou Gehrig's Disease (ALS)
SAN DIEGO – Apparent stem cell transplant success in mice may hold promise for people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease. The results of the study were released today and will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013.
Source: American Academy of Neurology - January 10, 2013 Category: Medical Law Source Type: news
Effects of Hydroxyapatite-Containing
Composite Nanofibers on Osteogenesis of Mesenchymal Stem Cells In
vitro and Bone Regeneration In vivo
ACS Applied Materials & InterfacesDOI: 10.1021/am302146w
Source: ACS Applied Materials and Interfaces - January 10, 2013 Category: Materials Science Authors: Lan-Xin Lü, Xiao-Feng Zhang, Yan-Yan Wang, Lazarus Ortiz, Xi Mao, Zan-Li Jiang, Zhong-Dang Xiao and Ning-Ping Huang Source Type: research
Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
& K Klauke
Source: Leukemia - January 10, 2013 Category: Hematology Authors: V RadulovićG de HaanK Klauke Tags: Polycomb group genes hematopoiesis stem cells lymphoma Source Type: research
Modeling the blood¿brain barrier using stem cell sources
The blood–brain barrier (BBB) is a selective endothelial interface that controls trafficking between the bloodstream and brain interstitial space. During development, the BBB arises as a result of complex multicellular interactions between immature endothelial cells and neural progenitors, neurons, radial glia, and pericytes. As the brain develops, astrocytes and pericytes further contribute to BBB induction and maintenance of the BBB phenotype. Because BBB development, maintenance, and disease states are difficult and time-consuming to study in vivo, researchers often utilize in vitro models for simplified analyses and ...
Source: Cerebrospinal Fluid Research - January 10, 2013 Category: Neurology Authors: Ethan LippmannAbraham Al-AhmadSean PalecekEric Shusta Source Type: research
CD146, a multi-functional molecule beyond adhesion
Highlights: ► CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular junction of endothelial cells. ► CD146 was originally identified as a marker for melanoma (MCAM). ► CD146 is not just a CAM for the inter-cellular and cell-matrix adhesion. ► CD146 is actively involved in miscellaneous processes, such as signaling transduction and angiogenesis. ► CD146 has been identified as a novel bio-marker for angiogenesis and for cancer.Abstract: CD146 is a cell adhesion molecule (CAM) that is primarily expressed at the intercellular junction of endothelial cells. CD146 was originally ident...
Source: Cancer Letters - January 10, 2013 Category: Cancer & Oncology Authors: Zhaoqing Wang, Xiyun Yan Tags: Mini-reviews Source Type: research
The role of Tα1 on the infective patients after hematopoietic stem cell transplantation.
Abstract The present study was designed to investigate the effect of thymosin α1 (Tα1) administration in infective recipients of hematopoietic stem cell transplantation (HSCT) for hematologic malignancies. Eight patients were enrolled in our study, including seven allo-HSCT patients and one auto-HSCT patient. These patients were allocated randomly into the treatment group (four cases) and control group (four cases). Tα1 was used in the treatment group to test its effectiveness in infection control. The concentrations of cytokines IFN-γ, IL-2, IL-4, IL-10, and IL-12 were observed, and the levels of CD3(+), CD4(+...
Source: International Journal of Hematology - January 10, 2013 Category: Hematology Authors: Ding JH, Wang LL, Chen Z, Wang J, Yu ZP, Zhao G, Chen BA Tags: Int J Hematol Source Type: research
Factors Expressed by Murine Embryonic Pancreatic Mesenchyme Enhance Generation of Insulin-Producing Cells From hESCs.
Abstract Islet transplantation has proven to be a successful strategy to restore normoglycemia in patients with type 1 diabetes (T1D). However, the dearth of cadaveric islets available for transplantation hampers the widespread application of this treatment option. Although human embryonic stem cells and induced pluripotent stem cells are capable of generating insulin-producing cells in vitro when provided with the appropriate inductive cues, the insulin-expressing cells that develop behave more like immature β-cells with minimal sensitivity to glucose stimulation. Here, we identify a set of signaling factors expr...
Source: Diabetes - January 10, 2013 Category: Endocrinology Authors: Guo T, Landsman L, Li N, Hebrok M Tags: Diabetes Source Type: research
Molecular Imaging of the Paracrine Proangiogenic Effects of Progenitor Cell Therapy in Limb Ischemia.
CONCLUSIONS: In limb ischemia, MAPC stimulate the recruitment of pro-angiogenic monocytes through endothelial activation and enhanced chemotaxis. These responses are sustained beyond MAPC lifespan suggesting that paracrine effects promote flow recovery by rebalancing the immune response toward a more regenerative phenotype. PMID: 23307829 [PubMed - as supplied by publisher]
Source: Circulation - January 10, 2013 Category: Cardiology Authors: Ryu JC, Davidson BP, Xie A, Qi Y, Zha D, Belcik JT, Caplan ES, Woda JM, Hedrick CC, Hanna RN, Lehman N, Zhao Y, Ting A, Lindner JR Tags: Circulation Source Type: research
Essential and Unexpected Role of YY1 to Promote Mesodermal Cardiac Differentiation.
Conclusions: These results demonstrate an essential and unexpected role for YY1 to promote cardiogenesis as a transcriptional activator of Nkx2.5 and other CPC-enriched genes. PMID: 23307821 [PubMed - as supplied by publisher]
Source: Circulation Research - January 10, 2013 Category: Cardiology Authors: Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM Tags: Circ Res Source Type: research
Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics
This study evaluated the plasmatic proteomic profile of breast cancer patients in the early (ED) and advanced (AD) stages, employing high-throughput proteomics. We identified 92 differentially expressed proteins in ED and 73 proteins in AD patients. Gelsolin, lumican, clusterin, SALL4 and PMS2, as well hTERT, TNF-α and GRHL3 were chosen for further investigation. ED presented augmented expression of GRHL3 and reduced circulating TNF-α with high expression of GRHL3 in tumors. AD displayed high TNF-α and a significant expression of PMS2 in tumors. These findings suggest processes enrolling stem cell division in ED, with T...
Source: Cancer Letters - January 10, 2013 Category: Cancer & Oncology Authors: Carolina Panis, Luciana Pizzatti, Ana Cristina Herrera, Rubens Cecchini, Eliana Abdelhay Tags: Research Articles Source Type: research
Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells.
In conclusion, we have proved that specified CD34+ EPCs are promising therapeutic agents for repairing damaged vasculature. PMID: 23301772 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - January 10, 2013 Category: Molecular Biology Authors: Shi Q, Schatten G, Hodara V, Simerly C, Vandeberg JL Tags: J Cell Mol Med Source Type: research
Hypoxia-inducing factors as master regulators of stemness properties and altered metabolism of cancer- and metastasis-initiating cells.
Abstract Accumulating lines of experimental evidence have revealed that hypoxia-inducible factors, HIF-1α and HIF-2α, are key regulators of the adaptation of cancer- and metastasis-initiating cells and their differentiated progenies to oxygen and nutrient deprivation during cancer progression under normoxic and hypoxic conditions. Particularly, the sustained stimulation of epidermal growth factor receptor (EGFR), insulin-like growth factor-1 receptor (IGF-1R), stem cell factor (SCF) receptor KIT, transforming growth factor-β receptors (TGF-βRs) and Notch and their downstream signalling elements such as phosphat...
Source: J Cell Mol Med - January 10, 2013 Category: Molecular Biology Authors: Mimeault M, Batra SK Tags: J Cell Mol Med Source Type: research
Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell-derived factor-1α
Abstract Prostate cancer frequently metastasizes to the bone, and the interaction between cancer cells and bone microenvironment has proven to be crucial in the establishment of new metastases. Bone marrow mesenchymal stem cells (BM-MSCs) secrete various cytokines that can regulate the behaviour of neighbouring cell. However, little is known about the role of BM-MSCs in influencing the migration and the invasion of prostate cancer cells. We hypothesize that the stromal cell-derived factor-1α released by BM-MSCs may play a pivotal role in these processes. To study the interaction between factors secreted by BM-MSCs...
Source: J Cell Mol Med - January 10, 2013 Category: Molecular Biology Authors: Mognetti B, Montagna GL, Perrelli MG, Pagliaro P, Penna C Tags: J Cell Mol Med Source Type: research
Understanding hair follicle cycling: a systems approach.
Abstract Continuous stem cell regeneration is essential for the repair and maintenance of many organs, rendering an understanding of the mechanisms underlying this phenomenon of prime importance. In this respect the hair follicle system provides an excellent test bed: mammalian skin contains thousands of hair follicles, each of which undergoes continuous regenerative cycling events that can be visualized via changing pigmentation patterns. Moreover, the system is inherently two-dimensional and reasonably easy to manipulate experimentally. Combined, the hair follicle system is an ideal candidate for an integrated th...
Source: Current Opinion in Genetics and Development - January 10, 2013 Category: Genetics & Stem Cells Authors: Baker RE, Murray PJ Tags: Curr Opin Genet Dev Source Type: research
Mesenchymal Stem Cells and Idiopathic Pulmonary Fibrosis: Potential for Clinical Testing.
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a progressive, debilitating, and fatal lung disease characterized by interstitial fibrosis with decreasing lung volumes and hypoxemic respiratory failure. The prognosis for patients with IPF is poor and the quest to find effective therapies has been unsuccessful. Despite several clinical trials over the past decade, there are no FDA approved treatments for patients with IPF and thus no standard of care. In terms of pathogenesis, IPF is characterized by alveolar epithelial cell injury and activation with interstitial inflammation, fibroblast proliferation with extracel...
Source: American Journal of Respiratory and Critical Care Medicine - January 10, 2013 Category: Respiratory Medicine Authors: Toonkel RL, Hare JM, Matthay MA, Glassberg MK Tags: Am J Respir Crit Care Med Source Type: research
Mesenchymal stem cells and their use in therapy: What has been achieved?
Abstract The considerable therapeutic potential of human multipotent mesenchymal stromal cells or mesenchymal stem cells (MSCs) has generated increasing interest in a wide variety of biomedical disciplines. Nevertheless, researchers report studies on MSCs using different methods of isolation and expansion, as well as different approaches to characterize them; therefore, it is increasingly difficult to compare and contrast study outcomes. To begin to address this issue, the Mesenchymal and Tissue Stem Cell Committee of the International Society for Cellular Therapy proposed minimal criteria to define human MSCs. Fir...
Source: Differentiation - January 10, 2013 Category: Research Authors: Fernández Vallone VB, Romaniuk MA, Choi H, Labovsky V, Otaegui J, Chasseing NA Tags: Differentiation Source Type: research
The expression of calcium-sensing receptor in mouse embryonic stem cells (mESCs) and its influence on differentiation of mESC into cardiomyocytes.
In conclusion, CaSR is functionally expressed in mESCs, and activation of CaSR is involved in the differentiation of mESCs into cardiomyocytes by facilitating the expression of NKx2.5 and GATA-4. PMID: 23314289 [PubMed - as supplied by publisher]
Source: Differentiation - January 10, 2013 Category: Research Authors: Sun J, He W, Bai SZ, Peng X, Zhang N, Li HX, Zhang WH, Wang LN, Shao XQ, He YQ, Yang GD, Wu LY, Wang R, Xu CQ Tags: Differentiation Source Type: research
Derivation of human embryonic stem cells using a post–inner cell mass intermediate
Nature Protocols 8, 254 (2013). doi:10.1038/nprot.2012.157 Authors: Thomas O'Leary, Björn Heindryckx, Sylvie Lierman, Margot Van der Jeught, Galbha Duggal, Petra De Sutter & Susana M Chuva de Sousa Lopes Little is known about the true developmental origin of human embryonic stem cells (hESCs) or the events that initiate their generation. Recently, we have shown that hESCs originate from a post–inner cell mass (ICM) intermediate (PICMI), a unique transient epiblast-like structure that is different from
Source: Nature Protocols - January 10, 2013 Category: Biomedical Science Authors: Thomas O'LearyBjörn HeindryckxSylvie LiermanMargot Van der JeughtGalbha DuggalPetra De SutterSusana M Chuva de Sousa Lopes Tags: Protocol Source Type: research
Characterization of pluripotent stem cells
Nature Protocols 8, 223 (2013). doi:10.1038/nprot.2012.154 Authors: Mercè Martí, Lola Mulero, Cristina Pardo, Cristina Morera, Meritxell Carrió, Leopoldo Laricchia-Robbio, Concepcion Rodriguez Esteban & Juan Carlos Izpisua Belmonte Characterization of pluripotent stem cells is required for the registration of stem cell lines and allows for an impartial and objective comparison of the results obtained when generating multiple lines. It is therefore crucial to establish specific, fast and reliable protocols to detect the hallmarks
Source: Nature Protocols - January 10, 2013 Category: Biomedical Science Authors: Mercè MartíLola MuleroCristina PardoCristina MoreraMeritxell CarrióLeopoldo Laricchia-RobbioConcepcion Rodriguez EstebanJuan Carlos Izpisua Belmonte Tags: Protocol Source Type: research
This Week in Science
Mini Mighty Muscle | Macrophage JNK in Metabolic Disease | Tracking Quantum Evolution | Ribosomal Rotaxane? | Pupfish Speciation | A Varied Bouquet | Optimizing Carbon Nanotubes | Stress Protector | Size Affects Shape | The Adult Astrocyte Is Different | Destination Specificity | Repair and Recombination | SAM, Histones, and Stem Cells | Diffraction Before Destruction
Source: Science: Current Issue - January 10, 2013 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny [Research Papers]
The accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process. Here, we performed conditional deletion of Brca1 during epidermal development and found that BRCA1 is specifically required for hair follicle (HF) formation and for development of adult HF stem cells (SCs). Mice deficient for Brca1 in the epidermis are hairless and display a reduced number of HFs that degenerate progressively. Surprisingly, the interfollicular epidermis and the sebaceous glands remain unaffected by Brca1 deletion. Interestin...
Source: Genes and Development - January 10, 2013 Category: Genetics & Stem Cells Authors: Sotiropoulou, P. A., Karambelas, A. E., Debaugnies, M., Candi, A., Bouwman, P., Moers, V., Revenco, T., Rocha, A. S., Sekiguchi, K., Jonkers, J., Blanpain, C. Tags: Research Papers Source Type: research
Successful transplantation of human hepatic stem cells with restricted localization to liver using hyaluronan grafts†
Abstract Cell therapies are potential alternatives to organ transplantation for liver failure or dysfunction but are compromised by inefficient engraftment, cell dispersal to ectopic sites, and emboli formation. Grafting strategies have been devised for transplantation of human hepatic stem cells (hHpSCs) embedded into a mix of soluble signals and extracellular matrix biomaterials (hyaluronans, type III collagen, laminin) found in stem cell niches. The hHpSCs maintain a stable stem cell phenotype under the graft conditions. The grafts were transplanted into the livers of immunocompromised murine hosts with and without carb...
Source: Hepatology - January 10, 2013 Category: Internal Medicine Authors: Rachael A. Turner, Eliane Wauthier, Oswaldo Lozoya, Randall McClelland, James E. Bowsher, Claire Barbier, Glenn Prestwich, Edward Hsu, David A. Gerber, Lola M. Reid Tags: Liver Injury/Regeneration Source Type: research
Allogeneic, but not autologous, hematopoietic cell transplantation improves survival only among younger adults with acute lymphoblastic leukemia in first remission: an individual patient data meta-analysis
Hematopoietic cell transplantation (HCT) and prolonged chemotherapy are standard postremission strategies for adult acute lymphoblastic leukemia in first complete remission, but the optimal strategy remains controversial. There are no randomized trials of allogeneic HCT. In the present study, updated individual patient data were collected and analyzed from studies with information on availability of matched sibling donor (used to mimic randomization) and from randomized trials of autograft versus chemotherapy. Data from 13 studies including 2962 patients, excluding Philadelphia chromosome–positive patients, showed a ...
Source: Blood - January 10, 2013 Category: Hematology Authors: Gupta, V., Richards, S., Rowe, J., on behalf of the Acute Leukemia Stem Cell Transplantation Trialists' Collaborative Group Tags: Transplantation, Free Research Articles, Lymphoid Neoplasia, Editorials, Clinical Trials and Observations Source Type: research
WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions
We examined the significance of WT1-CTL responses in patients with relapsed MM and high-risk cytogenetics who were undergoing allogeneic T cell–depleted hematopoietic stem cell transplantation (alloTCD-HSCT) followed by donor lymphocyte infusions. Of 24 patients evaluated, all exhibited WT1-CTL responses before allogeneic transplantation. These T-cell frequencies were universally correlated with pretransplantation disease load. Ten patients received low-dose donor lymphocyte infusions beginning 5 months after transplantation. All patients subsequently developed increments of WT1-CTL frequencies that were associated w...
Source: Blood - January 10, 2013 Category: Hematology Authors: Tyler, E. M., Jungbluth, A. A., O'Reilly, R. J., Koehne, G. Tags: Immunobiology, Transplantation, Lymphoid Neoplasia Source Type: research
Prognostic impact of immune status and hematopoietic recovery before and after fludarabine, IV busulfan and antithymocyte globulins (FB2 regimen) reduced‐intensity conditioning regimen (RIC) allogeneic stem cell transplantation (allo‐SCT)
Abstract This retrospective analysis aimed to assess hematopoietic and immune recovery in a cohort of 53 patients (males: n=33; median age: 59 years (range: 22‐70)) who received a FB2 (fludarabine 120‐150 mg/m² + IV busulfan 6.4 mg/Kg + ATG thymoglobuline 5mg/Kg) reduced‐intensity conditioning (RIC) allo‐SCT. With a median follow‐up of 19 months (range: 2‐53), the 2‐year OS, DFS, relapse incidence, and NRM were 63%, 59.5%, 35% and 6%, respectively. In univariate analysis, the factors correlated with a significantly higher 2‐year OS and DFS were a higher total circulating lymphocytes count at transplant (&g...
Source: European Journal of Haematology - January 10, 2013 Category: Hematology Authors: Amandine Bourgeois, Elsa Lestang, Thierry Guillaume, Jacques Delaunay, Sameh Ayari, Nicolas Blin, Aline Clavert, Benoit Tessoulin, Viviane Dubruille, Beatrice Mahe, Virginie Roland, Thomas Gastinne, Steven Gouill, Philippe Moreau, Mohamad Mohty, Lucie Pla Tags: Original Article Source Type: research
Stem cells found to heal damaged artery in lab study
(Texas Biomedical Research Institute) Scientists at the Texas Biomedical Research Institute in San Antonio have for the first time demonstrated that baboon embryonic stem cells can be programmed to completely restore a severely damaged artery. These early results show promise for eventually developing stem cell therapies to restore human tissues or organs damaged by age or disease.
Source: EurekAlert! - Medicine and Health - January 10, 2013 Category: Global & Universal Source Type: news
3-D biomimetic scaffolds support regeneration of complex tissues from stem cells
(Mary Ann Liebert, Inc./Genetic Engineering News) Stem cells can be grown on biocompatible scaffolds to form complex tissues such as bone, cartilage, and muscle for repair and regeneration of damaged or diseased tissue. However, to function properly, the cells must often grow in a specific pattern or alignment.
Source: EurekAlert! - Medicine and Health - January 10, 2013 Category: Global & Universal Source Type: news
Hypoxia‐inducing factors as master regulators of stemness properties and altered metabolism of cancer‐ and metastasis‐initiating cells
Abstract Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors, HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐ and metastasis‐initiating cells and their differentiated progenies to oxygen and nutrient deprivation during cancer progression under normoxic and hypoxic conditions. Particularly, the sustained stimulation of epidermal growth factor receptor (EGFR), insulin‐like growth factor‐1 receptor (IGF‐1R), stem cell factor (SCF) receptor KIT, transforming growth factor‐β receptors (TGF‐βRs) and Notch and their downstream signalling elements such...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Murielle Mimeault, Surinder K. Batra Tags: Review Article Source Type: research
Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell‐derived factor‐1α
Abstract Prostate cancer frequently metastasizes to the bone, and the interaction between cancer cells and bone microenvironment has proven to be crucial in the establishment of new metastases. Bone marrow mesenchymal stem cells (BM‐MSCs) secrete various cytokines that can regulate the behaviour of neighbouring cell. However, little is known about the role of BM‐MSCs in influencing the migration and the invasion of prostate cancer cells. We hypothesize that the stromal cell‐derived factor‐1α released by BM‐MSCs may play a pivotal role in these processes. To study the interaction between factors secreted by BM‐...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Barbara Mognetti, Giuseppe La Montagna, Maria Giulia Perrelli, Pasquale Pagliaro, Claudia Penna Tags: Original Article Source Type: research
Endothelial reconstitution by CD34+ progenitors derived from baboon embryonic stem cells
In conclusion, we have proved that specified CD34+ EPCs are promising therapeutic agents for repairing damaged vasculature.
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Qiang Shi, Gerald Schatten, Vida Hodara, Calvin Simerly, John L. VandeBerg Tags: Original Article Source Type: research
Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression
In this study, we found that Sox2 directly up-regulates the expression of survivin, which inhibits the mitochondria-dependent apoptotic pathway in NSCs. While over-expression of Sox2 elevates the survivin expression, knock-down of Sox2 results in a decrease in survivin expression, thereby initiating the mitochondria-dependent apoptosis related with caspase-9 activation. Furthermore, cell apoptosis due to Sox2 knock-down can be rescued by ectopically expressing survivin in NSCs as well as in the mouse brain, as demonstrated by an in utero-injection approach. In short, we have found a novel Sox2-survivin pathway that regulat...
Source: BJ Signal - January 10, 2013 Category: Biochemistry Authors: R Feng, S Zhou, Y Liu, D Song, Z Luan, X Dai, Y Li, N Tang, J Wen, L Li Tags: BJ Signal Source Type: research
The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers
ConclusionsBerEP4 differentiates between MAC and morpheaform BCC but not between MAC and DTE whereas PHLDA1 differentiates between DTE and morpheaform BCC but shows variable staining in MAC. CK15 and CK19 are helpful adjuncts in the differential diagnosis of sclerosing adnexal neoplasms but are second in line to BerEP4 and PHLDA1. We propose an algorithm for the immunohistochemical work‐up of sclerosing adnexal neoplasms.
Source: Journal of Cutaneous Pathology - January 10, 2013 Category: Pathology Authors: Klaus Sellheyer, Paula Nelson, Heinz Kutzner, Rajiv M. Patel Tags: Original Article Source Type: research
Systemic Administration of Human Adipose-Derived Stem Cells Reverts Nociceptive Hypersensitivity in an Experimental Model of Neuropathy
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 9, 2013 Category: Stem Cells Tags: article Source Type: research
Bioengineers Unveil New Scaffold to Repair Damaged Corneas Bioengineers Unveil New Scaffold to Repair Damaged Corneas
Researchers are optimistic that a new biodegradable substrate for limbal stem cell transplants may make treatment for corneal damage available to more patients. Medscape Medical News
Source: Medscape Today Headlines - January 9, 2013 Category: Consumer Health News Tags: Ophthalmology News Source Type: news
Rituximab failed to improve survival after stem cell transplant for DLBCL
Gisselbrecht C. J Clin Oncol. 2012;doi:10.1200/JCO.2012.41.9416.
Source: HemOncToday.com - January 9, 2013 Category: Cancer & Oncology Source Type: news
Stem cells may hold promise for Lou Gehrig’s disease (ALS)
Apparent stem cell transplant success in mice may hold promise for people with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, according to results of a new study.
Source: ScienceDaily Headlines - January 9, 2013 Category: Science Source Type: news
Supreme Court Won’t Hear Stem Cell Case
High court ends lawsuit against federal funding of human embryonic stem cell research
Source: Chemical and Engineering News - January 9, 2013 Category: Chemistry Authors: Britt E. Erickson Source Type: research
Why many would-be life-saving donors back out
Upon being identified as potential bone marrow or blood stem cell donors, many people choose not to participate. As result, patients with blood cancers go without life-saving treatments.
Source: WDSU.com - Health - January 9, 2013 Category: Consumer Health News Source Type: news
Stem Cell Transplants in Animal Model of ALS PromisingStem Cell Transplants in Animal Model of ALS Promising
Study of reprogrammed adult cells that were transplanted into mouse models of amyotrophic lateral sclerosis showed extended lifespan and improved function. Medscape Medical News
Source: Medscape Today Headlines - January 9, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells
Nifuji & Masumi Abe The advantages of using induced pluripotent stem cells (iPSCs) instead of embryonic stem (ES) cells in regenerative medicine centre around circumventing concerns about the ethics of using ES cells and the likelihood of immune rejection of ES-cell-derived tissues. However, partial reprogramming and genetic instabilities in iPSCs could elicit immune responses in transplant recipients even when iPSC-derived differentiated cells are transplanted. iPSCs are first differentiated into specific types of cells in vitro for subsequent transplantation. Although model transplantation experiments have been...
Source: Nature - January 9, 2013 Category: Research Authors: Ryoko ArakiMasahiro UdaYuko HokiMisato SunayamaMiki NakamuraShunsuke AndoMayumi SugiuraHisashi IdenoAkemi ShimadaAkira NifujiMasumi Abe Tags: Letter Source Type: research
Selective Elimination of Human Pluripotent Stem Cells by an Oleate Synthesis Inhibitor Discovered in a High-Throughput Screen.
Abstract The use of human pluripotent stem cells (hPSCs) in cell therapy is hindered by the tumorigenic risk from residual undifferentiated cells. Here we performed a high-throughput screen of over 52,000 small molecules and identified 15 pluripotent cell-specific inhibitors (PluriSIns), nine of which share a common structural moiety. The PluriSIns selectively eliminated hPSCs while sparing a large array of progenitor and differentiated cells. Cellular and molecular analyses demonstrated that the most selective compound, PluriSIn #1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs. Close ex...
Source: Cell Stem Cell - January 9, 2013 Category: Stem Cells Authors: Ben-David U, Gan QF, Golan-Lev T, Arora P, Yanuka O, Oren YS, Leikin-Frenkel A, Graf M, Garippa R, Boehringer M, Gromo G, Benvenisty N Tags: Cell Stem Cell Source Type: research
Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells.
Abstract Embryonic development is characterized by dynamic changes in gene expression, yet the role of chromatin remodeling in these cellular transitions remains elusive. To address this question, we profiled the transcriptome and select chromatin modifications at defined stages during pancreatic endocrine differentiation of human embryonic stem cells. We identify removal of Polycomb group (PcG)-mediated repression on stage-specific genes as a key mechanism for the induction of developmental regulators. Furthermore, we discover that silencing of transitory genes during lineage progression associates with reinstatem...
Source: Cell Stem Cell - January 9, 2013 Category: Stem Cells Authors: Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M Tags: Cell Stem Cell Source Type: research
The Hippo superhighway: signaling crossroads converging on the Hippo/Yap pathway in stem cells and development.
Abstract Tissue regeneration is vital to the form and function of an organ. At the core of an organs' ability to self-renew is the stem cell, which maintains homeostasis, and repopulates injured or aged tissue. Tissue damage can dramatically change the dimensions of an organ, and during regeneration, an organ must halt growth once the original tissue dimensions have been restored. Therefore, stem cells must give rise to the appropriate number of differentiated progeny to achieve homeostasis. How this tissue-size checkpoint is regulated and how tissue size information relayed to stem cell compartments is unclear, ho...
Source: Current Opinion in Cell Biology - January 9, 2013 Category: Cytology Authors: Barry ER, Camargo FD Tags: Curr Opin Cell Biol Source Type: research
Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification.
Abstract VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because HSCs derive from arterial cells, it is unclear whether VEGFA directly contributes to HSC specification. This is an important question for our understanding of how HSCs are formed and for developing their production in vitro. Through knockdown of the regulator ETO2 in embryogenesis, we report a specific decrease in expression of medium/long Vegfa isoforms in somites. This...
Source: Developmental Cell - January 9, 2013 Category: Cytology Authors: Leung A, Ciau-Uitz A, Pinheiro P, Monteiro R, Zuo J, Vyas P, Patient R, Porcher C Tags: Dev Cell Source Type: research
Stem cells: Sending cells back in time
Nature Reviews Neuroscience 14, 78 (2013). doi:10.1038/nrn3432 Author: Sian Lewis Obtaining neural stem cells (NSCs) by reprogramming differentiated cells has tremendous therapeutic potential with few ethical problems. Wang et al. used episomal vectors to reprogram human urine cells (epithelial-like cells) into an expandable population of neural progenitors. They demonstrated that, both in vitro
Source: Nature Reviews Neuroscience - January 9, 2013 Category: Neuroscience Authors: Sian Lewis Tags: Research Highlight Source Type: research
Satellite Cells and the Muscle Stem Cell Niche
Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated process involving the activation of various cellular and molecular responses. As skeletal muscle stem cells, satellite cells play an indispensible role in this process. The self-renewing proliferation of satellite cells not only maintains the stem cell population but also provides numerous myogenic cells, which proliferate, differentiate, fuse, and lead to new myofiber formation and reconstitution of a functional contractile apparatus. The co...
Source: Physiological Reviews - January 9, 2013 Category: Physiology Authors: Yin, H., Price, F., Rudnicki, M. A. Tags: Articles Source Type: research