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This page shows you the most recent publications within this specialty of the MedWorm directory.

Cloning stem cells: What does it mean?
Earlier this week we saw a breakthrough in this field: A group of researchers published in the journal Cell proof that they had created embryonic stem cells through cloning. (Source: CNN.com - Health)
Source: CNN.com - Health - May 18, 2013 Category: Consumer Health News Source Type: news

Plant-Produced Human Recombinant Erythropoietic Growth Factors Support Erythroid Differentiation In Vitro
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 17, 2013 Category: Stem Cells Tags: article Source Type: research

Researchers Report Cloning Advance For Producing Stem Cells
Scientists reported this week in the journal Cell that they had used somatic cell nuclear transfer techniques to create a source of embryonic stem cells from the skin cells of a patient. George Daley, director of the stem cell transplantation program at Boston Children's Hospital, and Josephine Johnston of the Hastings Center discuss the research.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - May 17, 2013 Category: Consumer Health News Source Type: news

Molecular and Functional Evidence of HCN4 and Caveolin-3 Interaction During Cardiomyocyte Differentiation from Human Embryonic Stem Cells
Stem Cells and Development Jun 2013, Vol. 22, No. 11: 1717-1727. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 17, 2013 Category: Stem Cells Tags: article Source Type: research

Hot On The TRAIL Of Graft Vs. Host Disease
For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Breakthrough Marks The First Time Human Stem Cells Have Been Produced Via Nuclear Transfer
Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson's disease, multiple sclerosis, cardiac disease and spinal cord injuries. The research breakthrough, led by Shoukhrat Mitalipov, Ph.D... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

New Ways Of Generating Stem Cells For Patients With Dysfunctional Or Damaged Tissues And Organs
Somatic cell nuclear transfer (SCNT) is a technique in which the nucleus of a donor cell is transferred to an egg cell whose nucleus has been removed, generating embryos that are almost an identical genetic match to the donor individual. For the first time, a team of scientists has used SCNT to produce human embryonic stem cells (hESCs). This milestone, published by Cell Press in the journal Cell, opens up new avenues for using stem cells to understand patient-specific causes of disease and for developing personalized therapies... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 17, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Evidence for a common progenitor of epithelial and mesenchymal components of the liver
, P Bianco & M Tripodi (Source: Cell Death and Differentiation)
Source: Cell Death and Differentiation - May 17, 2013 Category: Cytology Authors: A ConigliaroL AmiconeV CostaM De Santis PuzzoniaC ManconeB SacchettiC CicchiniF GaribaldiD A BrennerT KisselevaP BiancoM Tripodi Tags: liver stem cell hepatic stellate cell cell transplantation differentiation Source Type: research

Adoptively transferred TRAIL+ T cells suppress GVHD and augment antitumor activity
Current strategies to suppress graft-versus-host disease (GVHD) also compromise graft-versus-tumor (GVT) responses. Furthermore, most experimental strategies to separate GVHD and GVT responses merely spare GVT function without actually enhancing it. We have previously shown that endogenously expressed TNF-related apoptosis-inducing ligand (TRAIL) is required for optimal GVT activity against certain malignancies in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). In order to model a donor-derived cellular therapy, we genetically engineered T cells to overexpress TRAIL and adoptively transferred ...
Source: Journal of Clinical Investigation - May 16, 2013 Category: Biomedical Science Authors: Arnab Ghosh, Yildirim Dogan, Maxim Moroz, Amanda M. Holland, Nury L. Yim, Uttam K. Rao, Lauren F. Young, Daniel Tannenbaum, Durva Masih, Enrico Velardi, Jennifer J. Tsai, Robert R. Jenq, Olaf Penack, Alan M. Hanash, Odette M. Smith, Kelly Piersanti, Cecil Source Type: research

Chemistry: Shepherding Stem Cells
Stem cells, because of their ability to differentiate into multiple cell types, are of interest in aiding tissue repair and for treating diseases such as diabetes. However, their lack of … [Read more] (Source: Editors' Choice)
Source: Editors' Choice - May 16, 2013 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research

Editors' Choice
Geophysics: Hawaii's Deep Plumbing System | Economics: A Look at the Data | Pathogens: The End of Antiquity | Chemistry: UN Coaxed to Neutrality | Chemistry: Shepherding Stem Cells | Physics: Spin Thermometers | Developmental Biology: Putting on the Brakes (Source: Science: Current Issue)
Source: Science: Current Issue - May 16, 2013 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research

[News & Analysis] Biomedicine: Human Stem Cells From Cloning, Finally
This time it looks like it's for real: Researchers have made personalized human embryonic stem cells with a method similar to how Dolly the sheep was cloned—though with an added jolt of caffeine.Author: Gretchen Vogel (Source: Science: Current Issue)
Source: Science: Current Issue - May 16, 2013 Category: Science Authors: Gretchen Vogel Source Type: research

Stem cell breakthrough
CNN's Elizabeth Cohen on cloned stem cells that could develop into muscle or nerve cells. (Source: CNN.com - Health)
Source: CNN.com - Health - May 16, 2013 Category: Consumer Health News Source Type: news

Human Cloning Moves a Step Closer
Scientists used cloning technology to transform human skin cells into embryonic stem cells, moving a step closer toward human cloning. (Source: WSJ.com: Health)
Source: WSJ.com: Health - May 16, 2013 Category: Pharmaceuticals Tags: FREE Source Type: news

Stem Cell Milestone Revives Intense Ethical Debate
Scientists in Oregon have achieved something that has eluded researchers for years. They have created stem cells that are tailored to individual patients, made from cloned embryos. That would open the door to treating many diseases, including Alzheimer's, Parkinson's, diabetes, spinal cord injuries and many others. But researchers face ethical dilemmas.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - May 16, 2013 Category: Consumer Health News Source Type: news

Synthetic Silicate Used To Stimulate Stem Cells Into Bone Cells
In new research published online in Advanced Materials, researchers from Brigham and Women's Hospital (BWH) are the first to report that synthetic silicate nanoplatelets (also known as layered clay) can induce stem cells to become bone cells without the need of additional bone-inducing factors. Synthetic silicates are made up of simple or complex salts of silicic acids, and have been used extensively for various commercial and industrial applications, such as food additives, glass and ceramic filler materials, and anti-caking agents... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Cloning, Stem Cells Long Mired In Legislative Gridlock
The news that scientists have successfully cloned a human embryo seems almost certain to rekindle a political fight that has raged, on and off, since the creation of Dolly the sheep. It's a fight that has, over the past decade and a half, produced a lot of heat and light and not a lot of policy.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - May 16, 2013 Category: Consumer Health News Source Type: news

Stem cells: Back to the future
The unexpected return of therapeutic cloning could reopen ethical arguments that seemed to have been laid to rest (Source: New Scientist - Health)
Source: New Scientist - Health - May 16, 2013 Category: Consumer Health News Source Type: research

Human Cloning Produces Embryonic Stem Cells
A major breakthrough has just been achieved in stem cell research. Through human cloning, American scientists have effectively produced early embryos and used them as a source of stem cells with a procedure similar to the one that produced "Dolly the sheep", the first mammal ever to be cloned. The finding was published in the journal Cell. Stem cells derived by somatic cell nuclear transfer (SCNT) have the potential to transform into any cell type, such as bone or brain tissue cells. They can be used to treat and help understand a wide range of conditions and health problems... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 16, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Cloning Is Used to Create Embryonic Stem Cells
Researchers fused skin cells with donated human eggs to create human embryos that were genetically identical to the person who provided the skin cells. (Source: NYT and Stem Cells)
Source: NYT and Stem Cells - May 16, 2013 Category: Stem Cells Source Type: news

Stem-cell-based strategy boosts immune system in mice
(University of California - San Francisco) Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory. The researchers showed that, in mice, the tissue can be used to foster the development of white blood cells the body needs to mount healthy immune responses and to prevent harmful autoimmune reactions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 16, 2013 Category: Global & Universal Source Type: news

Development of cardiac support bioprostheses for ventricular restoration and myocardial regeneration [BASIC SCIENCE]
CONCLUSIONS Myocardial infarction treated with stem cells associated with a collagen matrix and ventricular constraint device improves systolic and diastolic function, reducing adverse remodelling and fibrosis. The application of bioactive molecules and the recent development of nanobiotechnologies should open the door for the creation of a new semi-degradable ventricular support bioprosthesis, capable of controlled stability or degradation in response to physiological conditions of the left or right heart. (Source: European Journal of Cardio-Thoracic Surgery)
Source: European Journal of Cardio-Thoracic Surgery - May 16, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Shafy, A., Fink, T., Zachar, V., Lila, N., Carpentier, A., Chachques, J. C. Tags: BASIC SCIENCE Source Type: research

Experiment Brings Human Cloning One Step Closer
Scientists have used cloning technology to transform human skin cells into embryonic stem cells, an experiment that may revive the controversy over human cloning. (Source: WSJ.com: Health)
Source: WSJ.com: Health - May 15, 2013 Category: Pharmaceuticals Tags: FREE Source Type: news

Human stem cells created by cloning
Nature 497, 7449 (2013). http://www.nature.com/doifinder/10.1038/497295a Author: David Cyranoski Breakthrough sets up showdown with induced adult lines. (Source: Nature)
Source: Nature - May 15, 2013 Category: Research Authors: David Cyranoski Tags: News Source Type: research

Scientists create human embryos to make stem cells
For the first time, scientists have created embryos that are genetic copies of living people to make stem cells, which may help treat many diseases but also raises concerns about human cloning.For the first time, scientists have created human embryos that are genetic copies of living people and used them to make stem cells — a feat that paves the way for treating a range of diseases with personalized body tissues but also ignites fears of human cloning. (Source: Los Angeles Times - Science)
Source: Los Angeles Times - Science - May 15, 2013 Category: Science Source Type: news

Cloning Is Used to Create Embryonic Stem Cells
Researchers fused skin cells with donated human eggs to create human embryos that were genetically identical to the person who provided the skin cells. (Source: NYT Health)
Source: NYT Health - May 15, 2013 Category: Consumer Health News Authors: By ANDREW POLLACK Tags: Stem Cells (Embryonic) Cloning Research Medicine and Health Source Type: news

Patient-Specific Human Embryonic Stem Cells Created by Cloning
From Nature magazine [More] (Source: Scientific American Topic - Biotechnology)
Source: Scientific American Topic - Biotechnology - May 15, 2013 Category: Biotechnology Tags: Health,Technology,Society & Policy,Medical Technology,Biotechnology,Biotechnology,Ethics,Health,More Science Source Type: news

Scientists Use Cloning Technique to Produce Human Stem Cells
Breakthrough bypasses need to use cells from fertilized embryos (Source: WebMD Health)
Source: WebMD Health - May 15, 2013 Category: Consumer Health News Source Type: news

How Researchers Cloned Human Embryos
After decades of trying, scientists say they've finally figured out how to make personalized embryonic stem cells. One day, these designer cells may help treat an array of diseases. A jolt of caffeine and and a little electric shock helped to do the trick.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - May 15, 2013 Category: Consumer Health News Source Type: news

Nuclear Transfer Begets Embryonic Stem Cells (CME/CE)
(MedPage Today) -- For the first time, researchers have efficiently produced human embryonic stem cells, using a process similar to the one that produced the famous cloned sheep, Dolly. (Source: MedPage Today Primary Care)
Source: MedPage Today Primary Care - May 15, 2013 Category: Primary Care Source Type: news

Beating human heart cells produced from skin - video
Human embryonic stem cells have been harvested from cloned embryos for the first time and grown into beating heart cells (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - May 15, 2013 Category: Science Tags: Embryos Biology guardian.co.uk Cloning Human biology Stem cells Editorial Science Source Type: news

Scientists successfully clone human stem cells via skin cells
Somatic cell nuclear transfer allowed scientists for first time to use unfertilized egg cells to create cloned cells for research (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 15, 2013 Category: Consumer Health News Source Type: news

Scientists report first success in cloning human stem cells
It's been 17 years since Dolly the sheep was cloned from a mammary cell. And now scientists applied the same technique to make the first embryonic stem cell lines from human skin cells. (Source: CNN.com - Health)
Source: CNN.com - Health - May 15, 2013 Category: Consumer Health News Source Type: news

Human embryonic stem cells created from adult tissue for first time
The cells, made with cloning technique behind Dolly the sheep, have the potential to regenerate damaged organs and tissuesScientists have used the cloning technique that led to Dolly the sheep to turn human skin into embryonic stem cells – which can make any tissue in the body.The US team overcame technical problems that had frustrated researchers for more than a decade to create batches of the body's master cells from donated skin.The work will spark fresh interest in the use of cloning in medical research, and reignite the controversy over a procedure that demands a supply of human eggs, and the creation and destructio...
Source: Guardian Unlimited Science - May 15, 2013 Category: Science Authors: Ian Sample Tags: Embryos Ethics Biology World news guardian.co.uk Medical research Human biology UK news Stem cells Science Source Type: news

Human stem cells made using Dolly cloning technique
The landmark achievement revives the hope of being able to generate new tissues using a patient's own cells, eliminating the risk of immune rejection (Source: New Scientist - Health)
Source: New Scientist - Health - May 15, 2013 Category: Consumer Health News Source Type: research

Scientists Clone Human Embryos To Make Stem Cells
Scientists say they have successfully created personalized embryonic stem cells from a donor's skin. They hope these kinds of cells can someday be used to treat diseases such as diabetes and Parkinson's. But the discovery raises ethical concerns because it takes researchers a step closer to cloning humans.» E-Mail This » Add to Del.icio.us (Source: NPR Health and Science)
Source: NPR Health and Science - May 15, 2013 Category: Consumer Health News Source Type: news

Clues To Tooth Regeneration Provided By Alligator Stem Cell Study
Alligators may help scientists learn how to stimulate tooth regeneration in people, according to new research led by the Keck School of Medicine of USC. For the first time, a global team of researchers led by USC pathology Professor Cheng-Ming Chuong, M.D., Ph.D., has uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators. Their study, titled "Specialized stem cell niche enables repetitive renewal of alligator teeth," appears in Proceedings of the National Academy of Sciences, the official journal of the United States National Academy of Sciences... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 15, 2013 Category: Consumer Health News Tags: Dentistry Source Type: news

OHSU research team successfully converts human skin cells into embryonic stem cells
(Oregon Health & Science University) Scientists at Oregon Health & Science University have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson's disease, multiple sclerosis, cardiac disease and spinal cord injuries. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2013 Category: Global & Universal Source Type: news

Neuroscience: Cell transplants stem seizures
Nature 497, 7449 (2013). doi:10.1038/497290b Stem-cell therapy can reduce seizures in epileptic mice.Some forms of epilepsy are thought to be caused by dysfunctional cells in the hippocampus region of the brain. The affected cells, called inhibitory interneurons, help to regulate neural circuits. Robert Hunt, Scott Baraban and their colleagues (Source: Nature)
Source: Nature - May 15, 2013 Category: Research Tags: Research Highlights Source Type: research

Targeting self-renewal pathways in myeloid malignancies
A fundamental property of hematopoietic stem cells (HSCs) is the ability to self-renew. This is a complex process involving multiple signal transduction cascades which control the fine balance between self-renewal and differentiation through transcriptional networks. Key activators/regulators of self-renewal include chemokines, cytokines and morphogens which are expressed in the bone marrow niche, either in a paracrine or autocrine fashion, and modulate stem cell behaviour. Increasing evidence suggests that the downstream signaling pathways induced by these ligands converge at multiple levels providing a degree of redundan...
Source: Cell Communication and Signaling - May 15, 2013 Category: Molecular Biology Authors: William SandsMhairi CoplandHelen Wheadon Source Type: research

An intensified systemic trafficking of bone marrow‐derived stem/progenitor cells in patients with pancreatic cancer
In conclusion, we demonstrated that in patients with pancreatic cancer, intensified peripheral trafficking of selected populations of BMSCs occurs. This phenomenon seems to correlate with systemic activation of the CC, hepatocyte growth factor and S1P levels. In contrast to previous studies, we demonstrate herein that systemic SDF‐1 levels do not seem to be linked with increased mobilization of stem cells in patients with pancreatic cancer. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - May 15, 2013 Category: Molecular Biology Authors: Teresa Starzyńska, Krzysztof Dąbkowski, Wojciech Błogowski, Ewa Zuba‐Surma, Marta Budkowska, Daria Sałata, Barbara Dołęgowska, Wojciech Marlicz, Jerzy Lubikowski, Mariusz Z. Ratajczak Tags: Original Article Source Type: research

Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation
Abstract Stem cells have been shown to have the potential to provide a source of cells for applications to tissue engineering and organ repair. The mechanisms that regulate stem cell fate, however, mostly remain unclear. Mesenchymal stem cells (MSCs) are multipotent progenitor cells that are isolated from bone marrow and other adult tissues, and can be differentiated into multiple cell lineages, such as bone, cartilage, fat, muscles and neurons. Although previous studies have focused intensively on the effects of chemical signals that regulate MSC commitment, the effects of physical/mechanical cues of the microenvironment ...
Source: Journal of Cellular and Molecular Medicine - May 15, 2013 Category: Molecular Biology Authors: Yang‐Kao Wang, Christopher S. Chen Tags: Review Article Source Type: research

Human Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Masahito Tachibana, Paula Amato, Michelle Sparman, Nuria Marti Gutierrez, Rebecca Tippner-Hedges, Hong Ma, Eunju Kang, Alimujiang Fulati, Hyo-Sang Lee, Hathaitip Sritanaudomchai, Keith Masterson, Janine Larson, Deborah Eaton, Karen Sadler-Fredd, David Battaglia, David Lee, Diana Wu, Jeffrey Jensen, Phillip Patton, Sumita Gokhale, Richard L. Stouffer, Don Wolf, Shoukhrat Mitalipov. Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer .... (Source: Cell)
Source: Cell - May 14, 2013 Category: Cytology Source Type: research

Self-Correction of Chromosomal Abnormalities in Human Preimplantation Embryos and Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 14, 2013 Category: Stem Cells Tags: article Source Type: research

Long Noncoding RNAs: New Players in the Molecular Mechanism for Maintenance and Differentiation of Pluripotent Stem Cells
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - May 14, 2013 Category: Stem Cells Tags: article Source Type: research