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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 25.

New generation humanized mice for virus research: comparative aspects and future prospects.
Abstract Work with human specific viruses will greatly benefit from the use of an in vivo system that provides human target cells and tissues in a physiological setting. In this regard humanized mice (hu-Mice) have played an important role in our understanding of viral pathogenesis and testing of therapeutic strategies. Limitations with earlier versions of hu-Mice that lacked a functioning human immune system are currently being overcome. The new generation hu-Mouse models are capable of multilineage human hematopoiesis and generate T cells, B cells, macrophages and dendritic cells required for an adaptive human im...
Source: Virology - January 5, 2013 Category: Virology Authors: Akkina R Tags: Virology Source Type: research

Stem cells and the treatment of Parkinson's disease.
Abstract Progress in Parkinson's disease (PD) research has been hampered by the lack of an appropriate model which exhibits the core pathology seen in the human brain. Recent advances in deriving cells with neuronal phenotypes from patients with neurodegenerative disorders through cellular reprogramming offers a unique tool for disease modelling and may help shed light on the molecular pathogenesis the drives the progression of the disease. This technology may also help in establishing platforms for drug screening and open up exciting new prospects for cell grafting. In this review, we will discuss progress made in...
Source: Experimental Neurology - January 5, 2013 Category: Neurology Authors: Ali F, Stott SR, Barker RA Tags: Exp Neurol Source Type: research

Generation and Characterization of Human Cryptorchid-Specific Induced Pluripotent Stem Cells from Urine
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 4, 2013 Category: Stem Cells Tags: article Source Type: research

Cancer-Killing Immune Cells Made From Stem Cells
Researchers in Japan have for the first time shown it is possible to make cancer-specific immune system cells from induced pluripotent stem cells (iPSCs). Their work brings closer the day when therapies use cloned versions of patients' own cells to boost their immune system's natural ability to kill cancer cells. The researchers, from the RIKEN Research Centre for Allergy and Immunology in Yokohama, describe how they created cancer-specific killer T lymphocytes from iPSCs, in a paper published online on 3 January in the journal Cell Stem Cell...
Source: Health News from Medical News Today - January 4, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Confirmation of Parthenogenetic Identity by Recombination Signature in Human Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 4, 2013 Category: Stem Cells Tags: article Source Type: research

Transforming Pluripotency: An Exon-Level Study of Malignancy-Specific Transcripts in Human Embryonal Carcinoma and Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 4, 2013 Category: Stem Cells Tags: article Source Type: research

Cord-Blood-Derived Mesenchymal Stromal Cells Downmodulate CD4+ T-Cell Activation by Inducing IL-10-Producing Th1 Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - January 4, 2013 Category: Stem Cells Tags: article Source Type: research

Stem cell recruitment and angiogenesis of neuropeptide substance P coupled with self-assembling peptide nanofiber in a mouse hind limb ischemia model.
In this study, we developed bioactive peptides by immobilizing substance P into self-assembling peptides, and their MSCs recruiting ability and therapeutic effects were evaluated by using ischemic hind limb models. Limb ischemia was produced in athymic mice, and 1% (wt/vol) peptides were injected into ischemic sites (n = 6 in each group: ischemia, substance P, RADA16-II, RADA16-II + substance P, and RADA16-II + RADA-SP (bioactive peptides)). The tissues were harvested for histological analysis and tissue perfusion measurement at 1, 3, 7, and 28 days after injection. We observed that bioactive peptides assembled thems...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Kim JH, Jung Y, Kim BS, Kim SH Tags: Biomaterials Source Type: research

Suicide gene-mediated ablation of tumor-initiating mouse pluripotent stem cells.
Abstract Pluripotent stem cells, including embryonic stem (ES) and induced pluripotent stem (iPS) cells, serve as unlimited resources for cell replacement therapy and tissue engineering because such cells are capable of extensive proliferation in vitro and can give rise to lineages that represent any of the three embryonic germ layers. However, in the context of the in vivo behavior of cell transplants, key challenges need to be addressed and essential strategies should be developed before stem cells can be used in clinical practice. In the present study, we modified mouse ES/iPS cells to contain a suicide gene, ...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Chen F, Cai B, Gao Y, Yuan X, Cheng F, Wang T, Jiang M, Zhou Y, Lahn BT, Li W, Xiang AP Tags: Biomaterials Source Type: research

Comparative proteomic analysis of endothelial cells progenitor cells derived from cord blood- and peripheral blood for cell therapy.
In this study, we established endothelial progenitor cells derived from cord blood- and peripheral blood (CB- and PB-EPCs) and investigated their fundamental differences at the cellular and molecular levels through a combination of stem cell biology techniques and proteomic analysis. Our results suggest that specifically up-regulated factors such as STMIN 1, CFL 1, PARK 7, NME 1, GLO 1, HSP 27 and PRDX 2 in CB-EPCs as key elements that could be functionally active in ischemic regions. We also discussed functional behaviors important for inducing and maintaining long-lasting blood vessels under ischemic conditions. As a res...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Kim J, Jeon YJ, Kim HE, Shin JM, Chung HM, Chae JI Tags: Biomaterials Source Type: research

Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery.
Abstract Stem cell engineering, the manipulation and control of cells, harnesses tremendous potential for diagnosis and therapy of disease; however, it is still challenging to impart multifunctionalization onto stem cells to achieve both. Here we describe a mesenchymal stem cell (MSC)-based multifunctional platform to target orthotopic glioblastoma by integrating the tumor targeted delivery of mesenchymal stem cells and the multimodal imaging advantage of mesoporous silica nanoparticles (MSNs). Rapid cellular uptake, long retention time and stability of particles exemplify the potential that the combination of MSNs...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Huang X, Zhang F, Wang H, Niu G, Choi KY, Swierczewska M, Zhang G, Gao H, Wang Z, Zhu L, Choi HS, Lee S, Chen X Tags: Biomaterials Source Type: research

Neural stem cells encapsulated in a functionalized self-assembling peptide hydrogel for brain tissue engineering.
In this study, we specifically linked laminin-derived IKVAV motif on the C-terminal to enrich self-assembling peptide RADA(16) as a functional peptide-based scaffold. Our purpose is providing a functional self-assembling peptide 3D hydrogel with encapsulated neural stem cells to enhance the reconstruction of the injured brain. The physiochemical properties reported that RADA(16)-IKVAV can self-assemble into nanofibrous morphology with bilayer β-sheet structure and become gelationed hydrogel with mechanical stiffness similar to brain tissue. The in vitro results showed that the extended IKVAV sequence can serve as a signa...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Cheng TY, Chen MH, Chang WH, Huang MY, Wang TW Tags: Biomaterials Source Type: research

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury.
Abstract Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent ...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Riegler J, Liew A, Hynes SO, Ortega D, O'Brien T, Day RM, Richards T, Sharif F, Pankhurst QA, Lythgoe MF Tags: Biomaterials Source Type: research

Solid-supported lipid bilayers to drive stem cell fate and tissue architecture using periosteum derived progenitor cells.
Abstract A challenge to mimicking nature's "bottom up" approach to generate tissue is the coordination of cellular self-assembly and emergent phenotype. Here we create a biosynthetic platform to mimic native cell-cell interactions and to drive emergent tissue behavior by human multipotent cells from the periosteal niche, i.e. PDCs, whose regenerative capacity is equal or greater to those from the bone marrow niche. Western blots showed that human PDCs express proteins for both N-cadherin, a hallmark of mesenchymal condensation, as well as for ZO-1, a tight junction membrane protein conferring epithelial barrier mem...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Evans SF, Docheva D, Bernecker A, Colnot C, Richter RP, Knothe Tate ML Tags: Biomaterials Source Type: research

Stimulation of angiogenesis, neurogenesis and regeneration by side population cells from dental pulp.
In this study, we compared the regenerative potential of dental pulp, bone marrow and adipose tissue-derived CD31(-) side population (SP) cells isolated from an individual porcine source. Pulp CD31(-) SP cells expressed the highest levels of angiogenic/neurotrophic factors and had the highest migration activity. Conditioned medium from pulp CD31(-) SP cells produced potent anti-apoptotic activity and neurite outgrowth, compared to those from bone marrow and adipose CD31(-) SP cells. Transplantation of pulp CD31(-) SP cells in a mouse hindlimb ischemia model produced higher blood flow and capillary density than transplantat...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Ishizaka R, Hayashi Y, Iohara K, Sugiyama M, Murakami M, Yamamoto T, Fukuta O, Nakashima M Tags: Biomaterials Source Type: research

Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia.
In this study, 3D cell aggregates composed of human umbilical vein endothelial cells (HUVECs) and cord-blood mesenchymal stem cells (cbMSCs) were used for therapeutic neovascularization to rescue tissues from critical limb ischemia. Within the cell aggregates, homogeneously mixed HUVECs and cbMSCs had direct cell-cell contact with expressions of endogenous extracellular matrices and adhesion molecules. Although dissociated HUVECs/cbMSCs initially formed tubular structures on Matrigel, the grown tubular network substantially regressed over time. Conversely, 3D HUVEC/cbMSC aggregates seeded on Matrigel exhibited an extensive...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Chen DY, Wei HJ, Lin KJ, Huang CC, Wang CC, Wu CT, Chao KT, Chen KJ, Chang Y, Sung HW Tags: Biomaterials Source Type: research

The guidance of stem cell differentiation by substrate alignment and mechanical stimulation.
The objective of this study is to investigate the role of nanofiber matrix alignment and mechanical stimulation on MSC differentiation, focusing on elucidating the relative contribution of each parameter in guided regeneration of functional connective tissues. It is observed that nanofiber alignment directs MSC response to physiological loading and that fibroblastic differentiation requires a combination of physiologically-relevant cell-material interactions in conjunction with mechanical stimulation. Importantly, the results of this study reveal that systemic and readily controllable cues, such as scaffold alignment and o...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Subramony SD, Dargis BR, Castillo M, Azeloglu EU, Tracey MS, Su A, Lu HH Tags: Biomaterials Source Type: research

Engineered scaffold-free tendon tissue produced by tendon-derived stem cells.
In conclusion, this is a proof-of-concept study demonstrating that ESFTT could be a potentially new approach for tendon repair and regeneration. PMID: 23246065 [PubMed - in process]
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Ni M, Rui YF, Tan Q, Liu Y, Xu LL, Chan KM, Wang Y, Li G Tags: Biomaterials Source Type: research

The effect of overexpression of Dlx2 on the migration, proliferation and osteogenic differentiation of cranial neural crest stem cells.
Abstract Craniofacial skeleton mainly originate from the cranial neural crest stem cells (CNCCs), which is a subpopulation of neural crest stem cells (NCCs). Dlx2, a member of the homeodomain family of transcription factors, plays crucial roles in the development of the CNCCs derived craniofacial skeleton. Previous reports reveal that Dlx2-targeted null mutation resulted in anomalies in the skeletal derivatives of CNCCs in mice. Dlx2 overexpression in ova disturbed the migration and differentiation of affected CNCCs and induced the development of ectopic skeleton elements. However, whether Dlx2 overexpression can i...
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Dai J, Kuang Y, Fang B, Gong H, Lu S, Mou Z, Sun H, Dong Y, Lu J, Zhang W, Zhang J, Wang Z, Wang X, Shen G Tags: Biomaterials Source Type: research

The activation of directional stem cell motility by green light-emitting diode irradiation.
In conclusion, stem cells are sensitive to green LED irradiation-induced directional cell migration through activation of ERK signaling pathway via a wavelength-dependent phototransduction. PMID: 23261211 [PubMed - in process]
Source: Biomaterials - January 4, 2013 Category: Materials Science Authors: Ong WK, Chen HF, Tsai CT, Fu YJ, Wong YS, Yen DJ, Chang TH, Huang HD, Kuang-Sheng Lee O, Chien S, Hui-Chun Ho J Tags: Biomaterials Source Type: research

Are 'turbocharged' immune cells key to cancer cure?
Conclusion These two Japanese studies are valuable research, demonstrating that it is possible to take specialised immune cells and "turn" them into stem cells. These stem cells can then be used to generate a larger number of specialised immune cells. Importantly, these cells were shown to have the ability to target the same specific cellular markers as their "parent" immune cells, which means they would be expected to be similarly effective in targeting abnormal cells in humans (either melanoma skin cancers or HIV-infected cells in the respective studies) and triggering an immune response to attack a...
Source: NHS News Feed - January 4, 2013 Category: Consumer Health News Tags: Cancer Medical practice Source Type: news

Study Hints That Stem Cells Prepare For Maturity Much Earlier Than Anticipated
Unlike less versatile muscle or nerve cells, embryonic stem cells are by definition equipped to assume any cellular role. Scientists call this flexibility "pluripotency," meaning that as an organism develops, stem cells must be ready at a moment's notice to activate highly diverse gene expression programs used to turn them into blood, brain, or kidney cells. Scientists from the lab of Stowers Investigator Ali Shilatifard, Ph.D...
Source: Health News from Medical News Today - January 4, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

New Insights into Mechanisms of Stem Cell Daughter Fate Determination in Regenerative Tissues.
Abstract Stem cells can self-renew and differentiate over extended periods of time. Understanding how stem cells acquire their fates is a central question in stem cell biology. Early work in Drosophila germ line and neuroblast showed that fate choice is achieved by strict asymmetric divisions that can generate each time one stem and one differentiated cell. More recent work suggests that during homeostasis, some stem cells can divide symmetrically to generate two differentiated cells or two identical stem cells to compensate for stem cell loss that occurred by direct differentiation or apoptosis. The interplay of a...
Source: International Review of Cell and Molecular Biology - January 4, 2013 Category: Cytology Authors: Sada A, Tumbar T Tags: Int Rev Cell Mol Biol Source Type: research

Insights into Skeletal Muscle Development and Applications in Regenerative Medicine.
Abstract Embryonic and postnatal development of skeletal muscle entails highly regulated processes whose complexity continues to be deconstructed. One key stage of development is the satellite cell, whose niche is composed of multiple cell types that eventually contribute to terminally differentiated myotubes. Understanding these developmental processes will ultimately facilitate treatments of myopathies such as Duchenne muscular dystrophy (DMD), a disease characterized by compromised cell membrane structure, resulting in severe muscle wasting. One theoretical approach is to use pluripotent stem cells in a therapeu...
Source: International Review of Cell and Molecular Biology - January 4, 2013 Category: Cytology Authors: Tran T, Andersen R, Sherman SP, Pyle AD Tags: Int Rev Cell Mol Biol Source Type: research

Stem Cell Technology May Help Rejuvenate Immune Cells
Title: Stem Cell Technology May Help Rejuvenate Immune CellsCategory: Health NewsCreated: 1/3/2013 2:35:00 PMLast Editorial Review: 1/4/2013 12:00:00 AM
Source: MedicineNet HIV General - January 4, 2013 Category: Infectious Diseases Source Type: news

A simplified method for screening siblings for HLA identity using short tandem repeat (STR) polymorphisms.
Abstract Identifying an HLA-matched sibling donor for hematopoietic stem cell transplantation (HSCT) is time-consuming and expensive, and often limited by reimbursement caps imposed by insurance providers. To improve the effectiveness and efficiency of screening for HLA-matched siblings, we developed an assay for determining HLA identity using a panel of nine informative short tandem repeat (STR) loci located throughout the HLA complex. The STR panel was assessed for accuracy in identifying HLA-matched siblings in 88 family workups comprising a total of 132 related donor and recipient typing comparisons. All siblin...
Source: Human Immunology - January 4, 2013 Category: Allergy & Immunology Authors: Schiller JJ, Hopp KA, Pietz BC, Bick DP, Lau EC, Ellis TM Tags: Hum Immunol Source Type: research

Characterization of Ewing sarcoma associated cancer/testis antigens.
Abstract The prognosis of patients suffering from tumors of the Ewing family (EFT) is still poor. Immunotherapy strategies are pursued and EFT-specific antigens have to be identified as targets for cytotoxic T-lymphocytes (CTL). Due to the lack of expression of cancer/testis antigens (CTA) in normal tissues, these antigens are partially able to induce immune responses in cancer patients. Therefore, they are promising targets for immunotherapy. EFT are characterized by chromosomal rearrangements involving members of the TET (translocated in liposarcoma, Ewing sarcoma breakpoint region 1, TATA box binding protein-ass...
Source: Cancer Biology and Therapy - January 4, 2013 Category: Cancer & Oncology Authors: Mahlendorf DE, Staege MS Tags: Cancer Biol Ther Source Type: research

Therapeutic Effects of Human Mesenchymal Stem Cells In Ex Vivo Human Lungs Injured with Live Bacteria.
CONCLUSION: In Escherichia coli injured human lungs, mesenchymal stem cells restored alveolar fluid clearance, reduced inflammation and exerted anti-microbial activity, in part through keratinocyte growth factor secretion. PMID: 23292883 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 4, 2013 Category: Respiratory Medicine Authors: Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA Tags: Am J Respir Crit Care Med Source Type: research

Early cardiac retention of administered stem cells determines clinical efficacy of cell therapy in patients with dilated cardiomyopathy.
PMID: 23287451 [PubMed - in process]
Source: Circulation Research - January 4, 2013 Category: Cardiology Authors: Assmus B, Zeiher AM Tags: Circ Res Source Type: research

Comparative Gene Expression Profiling in Human-Induced Pluripotent Stem Cell--Derived Cardiocytes and Human and Cynomolgus Heart Tissue
Cardiotoxicity is one of the leading causes of drug attrition. Current in vitro models insufficiently predict cardiotoxicity, and there is a need for alternative physiologically relevant models. Here we describe the gene expression profile of human-induced pluripotent stem cell–derived cardiocytes (iCC) postthaw over a period of 42 days in culture and compare this profile to human fetal and adult as well as adult cynomolgus nonhuman primate (NHP, Macaca fascicularis) heart tissue. Our results indicate that iCC express relevant cardiac markers such as ion channels (SCN5A, KCNJ2, CACNA1C, KCNQ1, and KCNH2), tissue-spec...
Source: Toxicological Sciences - January 4, 2013 Category: Toxicology Authors: Puppala, D., Collis, L. P., Sun, S. Z., Bonato, V., Chen, X., Anson, B., Pletcher, M., Fermini, B., Engle, S. J. Tags: Research Article Source Type: research

Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors
Conclusion Activation of the SDF-1/CXCR4 axis can contribute to early stages of carcinogenesis primarily through recruitment of stromal cells and modulation of the progenitor niche.
Source: Gut - January 4, 2013 Category: Gastroenterology Authors: Shibata, W., Ariyama, H., Westphalen, C. B., Worthley, D. L., Muthupalani, S., Asfaha, S., Dubeykovskaya, Z., Quante, M., Fox, J. G., Wang, T. C. Tags: Editor's choice, Stomach and duodenum, Pancreatic cancer Source Type: research

miR-378 in Self-renewal [RNA]
MicroRNAs are short noncoding RNAs that are implicated in cell self- renewal and cancer development. We show that miR-378 is up-regulated in human cancers and found that tumor cells transfected with miR-378 acquired properties of tumor stem cells, including cell self-renewal. Overexpression of miR-378 enhanced cell survival and colony formation. Isolated from a single-cell colony, the miR-378-expressing cells formed tumors in nude mice at low cell densities. These cells expressed higher levels of miR-378 and formed more and larger spheres and colonies. We found that the miR-378-expressing cells contained a large number of ...
Source: Journal of Biological Chemistry - January 4, 2013 Category: Chemistry Authors: Deng, Z., Du, W. W., Fang, L., Shan, S. W., Qian, J., Lin, J., Qian, W., Ma, J., Rutnam, Z. J., Yang, B. B. Tags: Cell Biology Source Type: research

CNS Regeneration from Human pNSC [Developmental Biology]
Spinal cord injury (SCI) results in devastating motor and sensory deficits secondary to disrupted neuronal circuits and poor regenerative potential. Efforts to promote regeneration through cell extrinsic and intrinsic manipulations have met with limited success. Stem cells represent an as yet unrealized therapy in SCI. Recently, we identified novel culture methods to induce and maintain primitive neural stem cells (pNSCs) from human embryonic stem cells. We tested whether transplanted human pNSCs can integrate into the CNS of the developing chick neural tube and injured adult rat spinal cord. Following injection of pNSCs i...
Source: Journal of Biological Chemistry - January 4, 2013 Category: Chemistry Authors: Zhao, J., Sun, W., Cho, H. M., Ouyang, H., Li, W., Lin, Y., Do, J., Zhang, L., Ding, S., Liu, Y., Lu, P., Zhang, K. Tags: Neurobiology Source Type: research

Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet
Conclusions Pan-Trpv4–/– mice develop more severe OA with high-fat feeding, potentially due to more severe diet-induced obesity. The altered differentiation potential of Trpv4–/– progenitor cells may reflect the importance of this ion channel in the maintenance and turnover of mesodermally-derived tissues.
Source: Annals of the Rheumatic Diseases - January 4, 2013 Category: Rheumatology Authors: O'Conor, C. J., Griffin, T. M., Liedtke, W., Guilak, F. Tags: Obesity (nutrition), Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis Basic and translational research Source Type: research

Thermogenesis sells plasma freezer, thawer product line
Rancho Cordova-based stem cell technology company ThermoGenesis Corp. has sold one of its product lines to Helmer Scientific for an undisclosed sum of cash, the company announced Thursday. ThermoGenesis received the cash payment from the sale during the quarter ended Dec. 31. Noblesville, Ind.-based Helmer Scientific purchased ThermoGenesis’ plasma freezer and thawer product line as part of its growth strategy and “continuing commitment to providing high quality products to the medical and…
Source: bizjournals.com Health Care:Hospitals headlines - January 3, 2013 Category: Hospital Management Authors: Melanie Turner Source Type: research

Superior T memory stem cell persistence supports long-lived T cell memory
Long-lived memory T cells are able to persist in the host in the absence of antigen; however, the mechanism by which they are maintained is not well understood. Recently, a subset of human T cells, stem cell memory T cells (TSCM cells), was shown to be self-renewing and multipotent, thereby providing a potential reservoir for T cell memory throughout life. However, their in vivo dynamics and homeostasis still remain to be defined due to the lack of suitable animal models. We identified T cells with a TSCM phenotype and stem cell–like properties in nonhuman primates. These cells were the least-differentiated memory ...
Source: Journal of Clinical Investigation - January 3, 2013 Category: Biomedical Science Authors: Enrico Lugli, Maria H. Dominguez, Luca Gattinoni, Pratip K. Chattopadhyay, Diane L. Bolton, Kaimei Song, Nichole R. Klatt, Jason M. Brenchley, Monica Vaccari, Emma Gostick, David A. Price, Thomas A. Waldmann, Nicholas P. Restifo, Genoveffa Franchini, Mari Source Type: research

Stem Cell Technology May Help Rejuvenate Immune Cells
Manipulation of aging T-cells might help them defend against diseases such as HIV and cancer, researchers say
Source: The Doctors Lounge - Oncology - January 3, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Family Medicine, Infections, AIDS, Oncology, Research, News, Source Type: news

Gene Delivery to Cultured Embryonic Stem Cells Using Nanofiber-Based Sandwich Electroporation
Analytical ChemistryDOI: 10.1021/ac302140p
Source: Analytical Chemistry - January 3, 2013 Category: Chemistry Authors: Zhengzheng Fei, Yun Wu, Sadhana Sharma, Daniel Gallego-Perez, Natalia Higuita-Castro, Derek Hansford, John J. Lannutti and Ly James Lee Source Type: research

Stem Cell Technology May Help Rejuvenate Immune Cells
Manipulation of aging T-cells might help them defend against diseases such as HIV and cancer, researchers say Source: HealthDay Related MedlinePlus Pages: Immune System and Disorders, Stem Cells
Source: MedlinePlus Health News - January 3, 2013 Category: Consumer Health News Source Type: news

Stem cell technology could help harness patients' own immune cells to fight disease
Researchers reporting in two separate recent articles used stem cell technology to successfully regenerate patients' immune cells, creating large numbers that were long-lived and could recognize their specified targets: HIV-infected cells in one case and cancer cells in the other. The findings could help in the development of strategies to rejuvenate patients' exhausted immune responses.
Source: ScienceDaily Headlines - January 3, 2013 Category: Science Source Type: news

Researchers use stem cells to pinpoint cause of common type of sudden cardiac death
When a young athlete dies unexpectedly on the basketball court or the football field, it's both shocking and tragic. Now researchers have, for the first time, identified the molecular basis for a condition called hypertrophic cardiomyopathy that is the most common cause for this type of sudden cardiac death.
Source: ScienceDaily Headlines - January 3, 2013 Category: Science Source Type: news

Cancer-specific killer T cells created from induced pluripotent stem cells (iPSC)
Researchers in Japan report today that they have succeeded for the first time in creating cancer-specific immune system cells called killer T lymphocytes from induced pluripotent stem cells (iPS cells). To create these killer cells, the team first had to reprogram T lymphocytes specialized in killing a certain type of cancer, into iPS cells. The iPS cells then generated fully active, cancer-specific T lymphocytes. These lymphocytes regenerated from iPS cells could potentially serve as cancer therapy in the future.
Source: ScienceDaily Headlines - January 3, 2013 Category: Science Source Type: news

Sorting stem cells: Scientists propose a new way to isolate early stage embryonic stem cells
When an embryonic stem cell is in the first stage of its development it has the potential to grow into any type of cell in the body, a state scientists call undifferentiated. Using an electric field to pull stem cells through a fluid, a team of researchers from Scotland has now demonstrated a way to easily distinguish undifferentiated embryonic stem cells from later-stage stem cells whose fate is sealed.
Source: ScienceDaily Headlines - January 3, 2013 Category: Science Source Type: news

Study suggests gene variation may shape bladder cancer treatment
Patients who have inherited a specific common genetic variant develop bladder cancer tumors that strongly express a protein known as prostate stem cell antigen (PSCA), which is also expressed in many pancreatic and prostate tumors, according to new research.
Source: ScienceDaily Headlines - January 3, 2013 Category: Science Source Type: news

Treating Type 1 Diabetes With Stem Cells: A New Way ForwardTreating Type 1 Diabetes With Stem Cells: A New Way Forward
Advances in technology have allowed for a new way to transplant stem cell-derived beta cells for the treatment of type 1 diabetes. How might this affect the future of clinical practice? Developments to Watch
Source: Medscape Today Headlines - January 3, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology Expert Interview Source Type: news

Cellular Dynamics Announces Agreement with AstraZeneca on Use of iPSC-derived Human Cells in Drug Discovery Research
MADISON, Wis., Jan. 3, 2013 /PRNewswire/ -- Cellular Dynamics International, Inc. (CDI) today announced a Center of Excellence agreement with AstraZeneca to accelerate the pace of drug discovery through the use of human induced pluripotent stem cell...
Source: Drugs.com - Pharma News - January 3, 2013 Category: Pharmaceuticals Source Type: news

Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine.
Abstract Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their spe...
Source: Annual Review of Immunology - January 3, 2013 Category: Allergy & Immunology Authors: Frenette PS, Pinho S, Lucas D, Scheiermann C Tags: Annu Rev Immunol Source Type: research

Metabolic Makeover for HSCs.
Abstract Hematopoietic stem cells (HSCs) must at times exit quiescence to divide and produce differentiated blood cells. In this issue of Cell Stem Cell, Takubo et al. (2013) and Yu et al. (2013) show that these opposing actions require distinct metabolic programs to meet the changing energy demands of self-renewing HSCs. PMID: 23290130 [PubMed - in process]
Source: Cell Stem Cell - January 3, 2013 Category: Stem Cells Authors: Warr MR, Passegué E Tags: Cell Stem Cell Source Type: research

Keeping stem cells in check: a hippo balancing act.
Abstract Knowing when to stop proliferation is crucial for any regenerative process. In a recent issue of Nature,Barry et al. (2012) report that the Hippo pathway component YAP negatively regulates Wnt signaling, thereby preventing stem cell overpopulation after a regenerative response in the intestine. PMID: 23290131 [PubMed - in process]
Source: Cell Stem Cell - January 3, 2013 Category: Stem Cells Authors: Vermeulen L Tags: Cell Stem Cell Source Type: research