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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 31.

Reduction of germ cells in the Odysseus null mutant causes male fertility defect in Drosophila melanogaster.
Abstract Odysseus (OdsH) has been identified as a hybrid male sterility gene between Drosophila mauritiana and D. simulans with accelerated evolutionary rate in both expression and DNA sequence. Loss of a testis-specific expression of OdsH causes male fertility defect in D. melanogaster. Yet, the underlying mechanisms at the cellular level are unknown. In an attempt to identify the possible mechanisms and functional roles of OdsH in spermatogenesis, the cell numbers at different developmental stages during spermatogenesis between the OdsH null mutant and wild-type flies were compared. The results showed that the ea...
Source: Genes and Genetic Systems - December 24, 2012 Category: Genetics & Stem Cells Authors: Cheng YJ, Fang S, Tsaur SC, Chen YL, Fu HW, Patel NH, Ting CT Tags: Genes Genet Syst Source Type: research

New Cell-Based System Can Screen Drug Candidates For Cardiac Toxicity Long Before They Leave Lab
A new stem cell-derived system for screening experimental drugs for cardiotoxicity could identify dangerous side effects early in the development process, thereby potentially saving time, lives and money, according to Evan F. Cromwell, PhD, of Molecular Devices, LLC, Sunnyvale, CA, in a presentation at the American Society for Cell Biology's Annual Meeting, Dec 17 in San Francisco. Vioxx is probably the most notorious example of a blockbuster drug removed from the market after FDA approval because of adverse cardiac side effects, Dr...
Source: Health News from Medical News Today - December 24, 2012 Category: Consumer Health News Tags: Medical Devices / Diagnostics Source Type: news

LIM-homeobox transcription factor 1, alpha (LMX1A) inhibits tumourigenesis, epithelial-mesenchymal transition and stem-like properties of epithelial ovarian cancer.
CONCLUSIONS: The present study demonstrated, for the first time, that LMX1A is a bona fide tumour suppressor of ovarian cancer. The prognostic values of LMX1A may provide a biomarker for personalized treatments of ovarian cancer patients The mechanisms of LMX1A in EMT and stem-like properties in ovarian cancer warrants further investigation. PMID: 23270808 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - December 24, 2012 Category: Cancer & Oncology Authors: Chao TK, Yo YT, Liao YP, Wang YC, Su PH, Huang TS, Lai HC Tags: Gynecol Oncol Source Type: research

A New Approach to CD34+ Hematopoietic Progenitor Cell Counting.
Conclusions: We have designed a valid alternative approach for hematopoietic progenitor cell counting, and we show that different methods give different results. PMID: 23270627 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Marín P, Jover L, Petriz AJ Tags: Curr Stem Cell Res Ther Source Type: research

The assessment of cryopreservation conditions for human umbilical cord stroma-derived mesenchymal stem cells towards a potential use for stem cell banking.
Abstract Human umbilical cord stroma-derived mesenchymal stem cells (hUCS-MSCs) are considered as a remarkable and promising stem cell source to be potentially used in cellular therapies. While no graft rejection has been reported in the recipient organism even in xenotransplantation studies, they were also shown experimentally to attenuate tumor cell growth and gene transfers. In present study, we demonstrate a reliable, reproducible and efficient cryopreservation method of hUCS-MSCs resulting one of the highest cell survival rates reported so far. Conventional, computer-controlled multi-step slow freezing (MSSF),...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Balci D, Can A Tags: Curr Stem Cell Res Ther Source Type: research

Molecular signature of human amniotic fluid stem cells during fetal development.
Abstract Mid-gestation c-KIT+ amniotic fluid stem cells (AFSC) have an intermediate phenotype between embryonic and adult stem cells and are easy to reprogram to pluripotency. We previously showed that 1st trimester AFSC can be reprogrammed to functional pluripotency in a transgene-free approach. Despite both parental populations sharing a common phenotype, expressing CD29, CD44, CD73, CD90, CD105, SSEA4 and OCT4, 2nd trimester AFSC, contrary to 1st trimester cells, do not express NANOG, SSEA3, TRA-1-60 and TRA-1-81, and have slower growth kinetics. Here, we used the Illumina Beadstudio microarray platform to analy...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Moschidou D, Drews K, Eddaoudi A, Adjaye J, De Coppi P, Guillot PV Tags: Curr Stem Cell Res Ther Source Type: research

Deriving Hepatocyte-Like Cells from Placental Cells for Transplantation.
Abstract Human hepatocyte transplantation is being trialled in lieu of orthotopic liver transplants for patients with acute and chronic liver diseases. Stem cells that can be differentiated into hepatocyte-like cells may replace human hepatocytes that are difficult to source, culture and in critically short supply. Hepatocyte-like cells have been derived from embryonic and adult tissue stem cells using a combination of growth factors and chemical inducers. Stem cells derived from the human placenta have gained interest due to the unlimited supply of placental tissue, minimal issues associated with stem cell retriev...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Vaghjiani V, Vaithilingam V, Tuch B, Sievert W, Manuelpillai U Tags: Curr Stem Cell Res Ther Source Type: research

Soluble Factors of Amnion-Derived Cells in Treatment of Inflammatory and Fibrotic Pathologies.
Abstract Inflammation is a complex defense mechanism characterized by leukocyte migration from the vasculature into damaged tissues and subsequent deposition of extracellular matrix resulting in tissue repair. The inflammatory process is generally categorized into an acute, rapid response, and a persistent but slowly evolving chronic condition, which may progress into inflammatory diseases. An excessive deposition of extracellular matrix leads to overgrowth, hardening, and/or scarring of tissues, defined as fibrosis. The amnion has been used as biomaterial in medicine for over 100 years and has been proven valuable...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Silini A, Parolini O, Huppertz B, Lang I Tags: Curr Stem Cell Res Ther Source Type: research

Myogenic potential of mesenchymal stem cells - the case of adhesive fraction of human umbilical cord blood cells.
Abstract Different sources of stem cells are considered as a potential source of precursor cells that could participate and improve skeletal muscle regeneration. Under physiological conditions regeneration is based on the satellite cells, i.e. adult muscle precursor cells that are localized between muscle fiber and surrounding basal lamina. These cells remain quiescent but after skeletal muscle injury activate, proliferate, differentiate, and fuse to form new muscle fibers or reconstruct the damaged ones. As it was shown in many studies few populations of stem cells other than satellite cells are able to support th...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Grabowska I, Streminska W, Janczyk-Ilach K, Machaj EK, Pojda Z, Hoser G, Kawiak J, Moraczewski J, Ciemerych MA, Brzoska E Tags: Curr Stem Cell Res Ther Source Type: research

Wharton's jelly or bone marrow mesenchymal stromal cells improve cardiac function following myocardial infarction for more than 32 weeks in a rat model: A Preliminary Report.
Abstract The therapeutic effect of mesenchymal stromal cells (MSCs) following myocardial infarction (MI) is small. This may be due to differences in cellular sources and donor age, route of administration, in vitro cellular manipulations and the short time course of follow up in many animal studies. Here, we compared MSCs from two different sources (adult bone marrow or Wharton's jelly from umbilical cord) for their long-term therapeutic effect following MI in a rat model to evaluate the effect of donor age. MSCs (or control infusions) were given intravenously 24-48 hr after myocardial ischemia (MI) induced by coro...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: López Y, Lutjemeier B, Seshareddy K, Trevino EM, Hageman KS, Musch TI, Borgarelli M, Weiss ML Tags: Curr Stem Cell Res Ther Source Type: research

Immunogenicity and Immunomodulatory Properties of Hepatocyte-like Cells Derived from Human Amniotic Epithelial Cells.
Abstract Hepatocyte transplantation is being trialed as an alternative to whole organ transplant for patients with acute liver failure and liver specific metabolic diseases. Due to the scarcity of human hepatocytes, hepatocyte-like cells (HLC) generated from stem cells may become a viable alternative to hepatocyte transplantation. Human amniotic epithelial cells (hAEC) from the placenta have stem cell-like properties and can be differentiated into HLC. Naïve hAEC have low immunogenicity and exert immunomodulatory effects that may facilitate allogeneic transplantation. However, whether the immunogenicity and immuno...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Tee JY, Vaghjiani V, Liu YH, Murthi P, Chan J, Manuelpillai U Tags: Curr Stem Cell Res Ther Source Type: research

Mesenchymal Cells in the Treatment of Spinal Cord Injury : Current & Future Perspectives.
Mesenchymal Cells in the Treatment of Spinal Cord Injury : Current & Future Perspectives. Curr Stem Cell Res Ther. 2012 Dec 24; Authors: Vawda R, Fehlings MG Abstract Nearly 1.5 million people in the US live with a spinal cord injury (SCI). The cost to the health system is estimated at over $10billion annually likely because over 65% of SCIs occur at the cervical level. Despite medical advances, many SCI patients still experience substantial neurological disability and high dependency with severe loss of motor, sensory and autonomic function. The consensus from a combination of in vitro studies and in v...
Source: Current Stem Cell Research and Therapy - December 24, 2012 Category: Stem Cells Authors: Vawda R, Fehlings MG Tags: Curr Stem Cell Res Ther Source Type: research

Bone Marrow Mesenchymal Stem Cells: Fat On and Blast Off by FGF21.
Abstract Bone marrow mesenchymal stem cells (BMMSCs) are multipotent marrow stromal cells with the ability to differentiate into a variety of cell types required for tissue regeneration including osteoblasts and chondrocytes. Thus, they hold tremendous potential as powerful therapeutic strategies for the prevention and treatment of degenerative disorders including osteoporosis and osteoarthritis. The differentiation of BMMSCs into competing lineages such as osteoblasts and marrow adipocytes is regulated by various environmental cues and intrinsic signaling pathways. Here I highlight recent advances in the understan...
Source: The International Journal of Biochemistry and Cell Biology - December 24, 2012 Category: Biochemistry Authors: Wan Y Tags: Int J Biochem Cell Biol Source Type: research

Hemogenic Endothelium: A Vessel For Blood Production.
Abstract Blood cell production, or hematopoiesis, is critical to the survival of the developing mammalian embryo. The origins of hematopoietic stem cells, capable of giving rise to all blood cell types, are being revealed. During embryogenesis, hematopoietic stem and progenitor cells are generated from a unique population of vascular endothelium termed hemogenic endothelial cells. These unusual endothelial cells are found in a restricted number of sites in the conceptus and within a narrow window of embryonic development. Loss of hemogenic endothelial cells through gene ablation leads to a lack of blood production ...
Source: The International Journal of Biochemistry and Cell Biology - December 24, 2012 Category: Biochemistry Authors: Antas VI, Al-Drees MA, Prudence AJ, Sugiyama D, Fraser ST Tags: Int J Biochem Cell Biol Source Type: research

TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Abstract Graft-versus-host disease (GVHD) is the most common complication after hematopoietic stem cell transplantation. To clarify the role of Toll-like receptor 4 (TLR4), which is a major receptor for bacterial lipopolysaccharides (LPS), in the development of acute GVHD, we used a TLR4-knockout (TLR4(-/-)) mouse GVHD model and analyzed the underlying immunological mechanisms. When TLR4(-/-) mice were used as bone marrow and splenocyte cell graft donors or recipients, GVHD symptom occurrence and mortality were delayed compared to wild-type (TLR4(+/+)) mice. In addition, histopathological analyses revealed that in ...
Source: Cellular and Molecular Immunology - December 24, 2012 Category: Molecular Biology Authors: Zhao Y, Liu Q, Yang L, He D, Wang L, Tian J, Li Y, Zi F, Bao H, Yang Y, Zheng Y, Shi J, Xue X, Cai Z Tags: Cell Mol Immunol Source Type: research

Anti‐fungal drug usage in hematologic patients during a 4‐year period in an Asian university teaching hospital
Abstract Invasive fungal disease (IFD) is an important problem complicating the therapy of hematologic patients. We conducted a retrospective review of 275 hematologic patients who were prescribed anti‐fungal drugs in a four‐year period (2007–2010), of whom 130 (47%) had undergone hematopoietic stem cell transplantation. Antifungal prophylaxis with either fluconazole or itraconazole was given in 214 patients (78%). There were 414 prescriptions of anti‐fungal drugs (including liposomal amphotericin B, voriconazole, caspofungin, micafungin, anidulafungin), of which 361 prescriptions were empirical. There were fourtee...
Source: Internal Medicine Journal - December 24, 2012 Category: Internal Medicine Authors: Thomas S.Y. Chan, Yu‐Yan Hwang, Harinder Gill, Winnie W.W. Cheung, Eric Tse, Anskar Y.H. Leung, Chor‐Sang Chim, Albert K.W. Lie, Yok‐Lam Kwong Tags: Original Article Source Type: research

Enzyme accelerates malignant stem cell cloning in chronic myeloid leukemia
(University of California - San Diego) An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia, a cancer of the blood and marrow that experts say is increasing in prevalence.
Source: EurekAlert! - Medicine and Health - December 24, 2012 Category: Global & Universal Source Type: news

Milestones in Pediatric Cardiology: Making Possible the Impossible
Abstract Pediatric Cardiology as a discipline has been proposed to have been born on August 26, 1938, when Robert Gross at the age of 33 years, successfully ligated a patent ductus arteriosus of a 7 years girl at the Children's Hospital in Boston. In November 1944, Helen Taussig convinced Alfred Blalock to anastomose the left subclavian artery to the left pulmonary artery after Robert Gross had declined to cooperate with her. About the 1950s, at the University of Minneapolis, Clarence Walton Lillehei worked on a controlled “crossed circulation” in which the cardiopulmonary bypass machine was another human, generally on...
Source: Clinical Cardiology - December 24, 2012 Category: Cardiology Authors: Raffaella Mormile, Ilaria Quadrini, Umberto Squarcia Tags: Review Source Type: research

Industry Update: Latest developments in stem cell research and regenerative medicine
Regenerative Medicine , January 2013, Vol. 8, No. 1, Pages 9-15.
Source: Future Medicine: Regenerative Medicine - December 23, 2012 Category: Genetics & Stem Cells Tags: article Source Type: research

Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture
Regenerative Medicine , January 2013, Vol. 8, No. 1, Pages 39-48.
Source: Future Medicine: Regenerative Medicine - December 23, 2012 Category: Genetics & Stem Cells Tags: article Source Type: research

Stem Cells and Cancer Stem Cells, Volume 9
Therapeutic Applications in Disease and Injuryseries:Stem Cells and Cancer Stem CellsThis fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives ...
Source: Springer Biomedical Sciences titles - December 23, 2012 Category: Biomedical Science Tags: Cancer Research Source Type: news

Harnessing The ID In Glioma
Gliomas are the most common form of brain tumor. They are highly aggressive and effective treatments are not currently available. The tumors contain glioma initiating cells (GICs), a population that is highly similar to neural stem cells. GICs drive tumor progression and must stay in a particular extracellular niche in order to maintain their cancer-promoting, stem cell-like characteristics. In this issue of the Journal of Clinical Investigation, researchers led by Antonio Iavarone at Columbia University report on the role of ID proteins in glioma...
Source: Health News from Medical News Today - December 23, 2012 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Bone marrow localisation of metastatic melanoma and synchronous leukaemic evolution of low-risk myelodysplastic syndrome
We report a case of low-risk MDS, according to the international prognostic scoring systems (IPSS), which evolved into AML simultaneously to metastatic bone marrow localisation of malignant melanoma. Case report A 70-year-old man was diagnosed with myelodysplastic syndrome in 2006. He presented with complaints of weakness for a month. He referred arterial hypertension and myocardial infarction 3 years before, treated with coronary revascularisation. Blood analysis revealed mild macrocytic anaemia. Bone marrow biopsy and aspirate evaluation at diagnosis showed a slightly hypercellular marrow, with significant dysplasia...
Source: Journal of Clinical Pathology - December 23, 2012 Category: Pathology Authors: Ferla, V., Freyrie, A., Guidotti, F., Bonoldi, E., Gianelli, U., Cortelezzi, A. Tags: PostScript Source Type: research

How science confounded the year's gloom | Observer editorial
Higgs boson and landing Curiosity on Mars are just two of the great achievements of the past 12 monthsIn a year that saw Britain suffer double-dip recession; when crippling debt has risen to threaten a record number of households; when the nation faces losing its triple A credit rating; and the economy of the entire planet continues to flounder, it is hard to find many reasons to be cheerful. The human species, which has made so much of its sparkling intellect in recent decades, could fairly be accused of having made a recent hash of global affairs. It is a justifiable criticism, though it ignores some intriguing contradic...
Source: Guardian Unlimited Science - December 22, 2012 Category: Science Tags: Curiosity rover Nasa Particle physics Mars Higgs boson The Observer Science Editorials Space Comment is free Source Type: news

How science confounded the year's gloom
Higgs boson and landing Curiosity on Mars are just two of the great achievements of the past 12 monthsIn a year that saw Britain suffer double-dip recession; when crippling debt has risen to threaten a record number of households; when the nation faces losing its triple A credit rating; and the economy of the entire planet continues to flounder, it is hard to find many reasons to be cheerful. The human species, which has made so much of its sparkling intellect in recent decades, could fairly be accused of having made a recent hash of global affairs. It is a justifiable criticism, though it ignores some intriguing contradic...
Source: Guardian Unlimited Science - December 22, 2012 Category: Science Tags: Curiosity rover Nasa Particle physics Mars Higgs boson The Observer Science Editorials Space Comment is free Source Type: news

Mucopolysacccharidoses: from understanding to treatment, a century of discoveries
After the first description of a patient recognized as a MPS case was made in 1917, several similar cases were described and identified. Observations reported in the middle of the twentieth century concerning the presence of acid mucopolysaccharides (later called glycosaminoglycans, or GAGs) in tissues and especially in urine of patients were instrumental in providing an identity for these diseases, which became referred as "mucopolysaccharidoses" (MPS). In the late 1960's it was demonstrated that MPS were caused by defects in the breakdown of GAGs, and the specific enzyme deficiencies for the 11 types and subtypes of MPS ...
Source: Genetics and Molecular Biology - December 22, 2012 Category: Genetics & Stem Cells Source Type: research

Stem cell attraction via SDF-1α expressing fat tissue grafts.
Abstract Mesenchymal stromal cell (MSCs) are key cellular components for site-specific tissue regeneration. The chemokine stromal derived factor 1 alpha (SDF-1α) is known to attract stem cells via the C-X-C chemokine receptor-4 (CXCR4) receptor. The aim of the study was to develop a model for stem cell attraction using SDF-1α overexpressing fat tissue grafts. Murine MSCs were lentiviral transduced to express the genes for enhanced green fluorescent protein, firefly luciferace, and human CXCR4 (hCXCR4). Murine fat tissue was adenoviral transduced to express SDF-1α and red fluorescent protein transgenes. MSCs were...
Source: Biomed Res - December 22, 2012 Category: Research Authors: Zwingenberger S, Yao Z, Jacobi A, Vater C, D Valladares R, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Mätzig T, Günther KP, Goodman SB, Stiehler M Tags: J Biomed Mater Res A Source Type: research

Brain pericyte plasticity as a potential drug target in CNS repair.
Abstract Brain pericytes (BrPCs) are essential cellular components of the central nervous system neurovascular unit involved in the regulation of blood flow, blood-brain barrier function, as well as in the stabilization of the vessel architecture. More recently, it became evident that BrPCs, besides their regulatory activities in brain vessel function and homeostasis, have pleiotropic functions in the adult CNS ranging from stromal and regeneration promoting activities to stem cell properties. This special characteristic confers BrPC cell plasticity, being able to display features of other cells within the organism...
Source: Drug Discovery Today - December 22, 2012 Category: Drugs & Pharmacology Authors: Lange S, Trost A, Tempfer H, Bauer HC, Bauer H, Rohde E, Reitsamer HA, Franklin RJ, Aigner L, Rivera FJ Tags: Drug Discov Today Source Type: research

Human mesenchymal stem cells isolated from olfactory biopsies but not bone enhance CNS myelination in vitro
Abstract Spinal cord injury (SCI) is a devastating condition with limited capacity for repair. Cell transplantation is a potential strategy to promote SCI repair with cells from the olfactory system being promising candidates. Although transplants of human olfactory mucosa (OM) are already ongoing in clinical trials, the repair potential of this tissue remains unclear. Previously, we identified mesenchymal‐like stem cells that reside in the lamina propria (LP‐MSCs) of rat and human OM. Little is known about these cells or their interactions with glia such as olfactory ensheathing cells (OECs), which would be co‐trans...
Source: Glia - December 22, 2012 Category: Neurology Authors: Susan L. Lindsay, Steven A. Johnstone, Joanne C. Mountford, Saghir Sheikh, David B. Allan, Louise Clark, Susan C. Barnett Tags: Original Article Source Type: research

Transfer of Growth Factor Receptor mRNA Via Exosomes Unravels the Regenerative Effect of Mesenchymal Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Stemedica and Scripps to Jointly Investigate Therapeutic Effect of...
Stemedica Cell Technologies, Inc., a leading manufacturer of adult ischemia tolerant allogeneic stem cells and stem cell factors announced that the Company has signed an agreement with The Scripps...(PRWeb December 21, 2012)Read the full story at http://www.prweb.com/releases/stemedica-scripps-ards/stem-cell-factors-sepsis/prweb10263983.htm
Source: PRWeb: Medical Pharmaceuticals - December 21, 2012 Category: Pharmaceuticals Source Type: news

Implication of early lymphocyte recovery after allogeneic hematopoietic stem cell transplantation in children with leukemia.
Conclusion: Early posttransplant serial lymphocyte measurement would be a simple but useful method for predicting transplant outcomes. PMID: 23225800 [PubMed - in process]
Source: Yonsei Medical Journal - December 21, 2012 Category: Universities & Medical Training Authors: Han DK, Baek HJ, Kim SY, Hwang TJ, Kook H Tags: Yonsei Med J Source Type: research

Glioma stem cell-targeted dendritic cells as a tumor vaccine against malignant glioma.
Conclusion: The results demonstrated DCs loaded with antigens derived from glioma stem cells can effectively stimulate naive T cells to form specific cytotoxic T cells, kill glioma cells cultured in vitro. PMID: 23225804 [PubMed - in process]
Source: Yonsei Medical Journal - December 21, 2012 Category: Universities & Medical Training Authors: Ji B, Chen Q, Liu B, Wu L, Tian D, Guo Z, Yi W Tags: Yonsei Med J Source Type: research

Effect of Human Parathyroid Hormone on Hematopoietic Progenitor Cells in NOD/SCID Mice Co-Transplanted with Human Cord Blood Mononuclear Cells and Mesenchymal Stem Cells.
Conclusion: We have demonstrated a positive effect of hPTH on stem cell proliferation and a possible synergistic effect of MSCs and hPTH on the proportion of human hematopoietic progenitor cells, in a xenotransplantation model. Clinical trials of the use of hPTH after stem cell transplantation should be considered. PMID: 23225826 [PubMed - in process]
Source: Yonsei Medical Journal - December 21, 2012 Category: Universities & Medical Training Authors: Lim YJ, Hwang K, Kim M, Cho YH, Lee JH, Leelee YH, Seo JJ Tags: Yonsei Med J Source Type: research

Promoting Transplantation Tolerance; Adoptive Treg Cell Therapy
Abstract Transplantation is a successful treatment for end‐stage organ failure. Despite improvements in short term outcome, long‐term survival remains suboptimal because of the morbidity and mortality associated with long term use of immunosuppression. There is, therefore, a pressing need to devise protocols that induce tolerance in order to minimise or completely withdraw immunosuppression in the transplant recipients. In this review we will discuss how regulatory T cells (Tregs) came to be recognised as an attractive way to promote transplantation tolerance. We will summarise the pre‐clinical data, supporting the i...
Source: Clinical and Experimental Immunology - December 21, 2012 Category: Allergy & Immunology Authors: Safinia N, Leech J, Hernandez‐Fuentes M, Lechler R, Lombardi G Tags: Review Source Type: research

Epigenetic Regulation of Nestin Expression During Neurogenic Differentiation of Adipose Tissue Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Deleted in Azoospermia-Like Enhances In Vitro Derived Porcine Germ Cell Formation and Meiosis
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Efficient Induction of Pluripotent Stem Cells from Menstrual Blood
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Characterization of Human Adipose Tissue-Resident Hematopoietic Cell Populations Reveals a Novel Macrophage Subpopulation with CD34 Expression and Mesenchymal Multipotency
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Lectin from Erythrina cristagalli Supports Undifferentiated Growth and Differentiation of Human Pluripotent Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

The Impact of Cell Source, Culture Methodology, Culture Location, and Individual Donors on Gene Expression Profiles of Bone Marrow-Derived and Adipose-Derived Stromal Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Extracellular Purines Promote the Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells to the Osteogenic and Adipogenic Lineages
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - December 21, 2012 Category: Stem Cells Tags: article Source Type: research

Stem Cells Treat Lou Gehrig's Disease, In Mice
Reporting in Science Translational Medicine, researchers write that neural stem cell implants were able to slow the onset of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, in mice. Study author Evan Snyder discusses the stem cells' protective effect, and why human trials may not be far behind.» E-Mail This » Add to Del.icio.us
Source: NPR Health and Science - December 21, 2012 Category: Consumer Health News Source Type: news

Cadaver stem cells offer new hope of life after death
Stem cells can be extracted from bone marrow five days after death to be used in life-saving treatments
Source: New Scientist - Health - December 21, 2012 Category: Consumer Health News Source Type: research

Botched stem cell facelift leaves woman with bones growing in her EYES
One theory is the stem cells – which can develop into any tissue in the body – could have reacted with a common dermal filler which contains calcium, say Californian scientists.
Source: the Mail online | Health - December 21, 2012 Category: Consumer Health News Source Type: news

[Special Issue News] Breakthrough of the Year: The Runners-Up
A remarkable new method to prepare single strands of ancient DNA and view their genomes topped the list of this year's runners-up for Breakthrough of the Year, along with important discoveries into transcription activator–like effector nucleases, neutrino physics, Majorana fermions, the production of eggs cells from stem cells, and brain-machine interfaces. Other notable advances involve the Encyclopedia of DNA Elements, the Mars Curiosity rover, and the use of x-ray lasers to determine protein structure.
Source: Science: Current Issue - December 21, 2012 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research

Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes.
Abstract Mesenchymal stem cells (MSC) are heterogeneous cell populations with promising therapeutic potentials in regenerative medicine. The therapeutic values of MSC in various clinical situations have been reported. Clonal assays (expansion of MSC from a single cell) demonstrated that multiple types of cells with different developmental potential exist in a MSC population. Due to the heterogeneous nature of MSC, molecular characterization of MSC in the absence of known biomarkers is a challenge for cell therapy with MSC. Here, we review potential therapeutic applications of MSC and discuss a systematic approach f...
Source: Biotechnology Advances - December 21, 2012 Category: Biotechnology Authors: Li Z, Zhang C, Weiner LP, Chiou PY, Zhang Y, Zhong JF Tags: Biotechnol Adv Source Type: research

[Role of rituximab in the management of refractory autoimmune cytopenia.]
CONCLUSIONS: Overall, seventy one percent of patients in this study respond to treatment, 100% of responders decrease their previous treatment. Rituximab was a well tolerated and no related serious side effects were recorded during the study period. PMID: 23266244 [PubMed - as supplied by publisher]
Source: Anales de Pediatria - December 21, 2012 Category: Pediatrics Authors: Losa Frías V, García Sánchez AM, Ortiz Valentín I, González Vicent M, Velasco Arribas MR, Madero López L, Sevilla Navarro J Tags: An Pediatr (Barc) Source Type: research

Salsolinol induced apoptotic changes in neural stem cells: Amelioration by neurotrophin support.
In this study we explored the toxicity of SAL toward NSCs focusing on apoptosis and status of PI3K survival signaling. NSCs cultured from embryonic day 11 rat fetal brain including those differentiated to TH(+ve) colonies, when challenged with SAL (1-100μM), elicited a concentration and time dependent cell death/loss of mitochondrial viability. 10μM SAL on which significant mitochondrial impairment initiated was further used to study mechanism of toxicity. Morphological impairment, enhanced TUNEL positivity, cleaved caspase-3 and decreased Bcl-2:Bax suggested apoptosis. Sal toxicity coincided with reduced pAkt level and ...
Source: Neurotoxicology - December 21, 2012 Category: Neurology Authors: Shukla A, Mohapatra TM, Agrawal AK, Parmar D, Seth K Tags: Neurotoxicology Source Type: research

Placenta-Derived Mesenchymal Stem Cells Have an Immunomodulatory Effect That Can Control Acute Graft-Versus-Host Disease in Mice.
Conclusion: We present the first evidence that human PD-MSCs can efficiently control GVHD in an HSCT in vivo model. PMID: 23257958 [PubMed - as supplied by publisher]
Source: Acta Haematologica - December 21, 2012 Category: Hematology Authors: Jang MJ, Kim HS, Lee HG, Kim GJ, Jeon HG, Shin HS, Chang SK, Hur GH, Chong SY, Oh D, Chung HM Tags: Acta Haematol Source Type: research