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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 4.

StemCells stock rises as 2 spinal cord injury patients see gains
StemCells Inc.'s stock jumped nearly 21 percent Tuesday, after the Newark company said two of three patients with the worst kind of spinal cord injuries continued to show "considerable gains" in feelings a year after receiving an experimental stem cell treatment. The two patients who were able to detect touch, heat and electrical stimuli following treatment are part of the first three-patient cohort in a Phase I/II trial of StemCells' (NASDAQ: STEM) purified human neural stem cells, which are extracted…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 12, 2013 Category: Pharmaceuticals Authors: Ron Leuty Source Type: research

Release of Matrix Metalloproteinase-8 During Physiological Trafficking and Induced Mobilization of Human Hematopoietic Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

ThermoGenesis reports shrinking loss
Rancho Cordova-based stem cell technology company ThermoGenesis Corp. reported a shrinking year-over-year net loss in the second quarter, and gains in revenue. ThermoGenesis (NASDAQ: KOOL) reported a loss of $563,000, or 3 cents per share, compared to a net loss of $1.3 million, or 8 cents per share, in the same quarter, ended Dec. 31, a year earlier. The company reported second-quarter revenue of $4.8 million, which was comparable to the year-earlier quarter but up substantially from revenue of…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - February 12, 2013 Category: Pharmaceuticals Authors: Melanie Turner Source Type: research

Researchers Highlight Warning Signs On Adult Stem Cell Treatments
One of the virtues of adult stem cell research, so the story goes, is that it does not suffer either the ethical concerns or scientific problems involved in embryonic stem cell research.
Source: Forbes.com Healthcare News - February 12, 2013 Category: Pharmaceuticals Authors: John Farrell Source Type: news

Bioexplorers Find Tongue's Taste Bud Factory
Taste may be the least understood of our five senses. Even basic questions, like where do taste buds come from, remained mysterious. Until now. In a study published in the journal Stem Cell , scientists have identified the elusive "parental" cell that give rise to the daughter cells responsible for taste. [Karen K. Yee et al., Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue ] [More]
Source: Scientific American Topic - Stem Cell Research - February 12, 2013 Category: Stem Cells Tags: More Science,Biology,More Science Source Type: news

Specialized Tip/Stalk-Like and Phalanx-Like Endothelial Cells from Embryonic Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

α2-Macroglobulin Enhances Vasculogenesis/Angiogenesis of Mouse Embryonic Stem Cells by Stimulation of Nitric Oxide Generation and Induction of Fibroblast Growth Factor-2 Expression
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

Notch Signaling Is Involved in Neurogenic Commitment of Human Periodontal Ligament-Derived Mesenchymal Stem Cells
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

Epigenetic Analysis and Suitability of Amniotic Fluid Stem Cells for Research and Therapeutic Purposes
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Stem Cells and Development , Vol. 0, No. 0.
Source: Stem Cells and Development - February 12, 2013 Category: Stem Cells Tags: article Source Type: research

Genes that cause short-sightedness discovered
Conclusion This study has identified 26 genetic variants found to be associated with problems in the way the eye focuses light (refractive errors). Two of the variants were linked to refractive errors previously, and 24 of the variants were new. Using data from people enrolled in a cohort study in Rotterdam, the researchers calculated that people with the most adverse genetic variants (those with the highest risk score) had a tenfold increase in the odds of becoming short-sighted. The highest risk score occurred in less than 5% of subjects. Although this is exciting research, contrary to some of the headlines, treatment...
Source: NHS News Feed - February 12, 2013 Category: Consumer Health News Tags: Genetics/stem cells Source Type: news

Stem Cell Breakthrough Could Lead To New Bone Repair Therapies On Nanoscale Surfaces
Scientists at the University of Southampton have created a new method to generate bone cells which could lead to revolutionary bone repair therapies for people with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis. The research, carried out by Dr Emmajayne Kingham at the University of Southampton in collaboration with the University of Glasgow and published in the journal Small, cultured human embryonic stem cells on to the surface of plastic materials and assessed their ability to change...
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Stem Cells and Cancer Stem Cells, Volume 9
Therapeutic Applications in Disease and Injuryseries:Stem Cells and Cancer Stem CellsThis fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, it offers an unrivalled breadth of differing perspectives ...
Source: Springer Biomedical Sciences titles - February 12, 2013 Category: Biomedical Science Tags: Cancer Research Source Type: news

Apogenix Receives FDA Orphan Drug Designation For Apocept(TM) To Treat Myelodysplastic Syndromes And Initiates Clinical Phase I Study
Apogenix GmbH, a clinical stage biopharmaceutical company developing novel protein therapeutics for the treatment of cancer and inflammatory diseases, announced today that its lead product, Apocept(TM) (APG101), has been granted orphan drug designation from the US Food and Drug Administration (FDA) for the treatment of Myelodysplastic syndromes (MDS). MDS are clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis leading to blood cytopenias, especially anemia...
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Artificial Bone Implants Make Light Work Of Fixing Broken Bones
Artificial bone, created using stem cells and a new lightweight plastic, could soon be used to heal shattered limbs. The use of bone stem cells combined with a degradable rigid material that inserts into broken bones and encourages real bone to re-grow has been developed at the Universities of Edinburgh and Southampton. Researchers have developed the material with a honeycomb scaffold structure that allows blood to flow through it, enabling stem cells from the patient's bone marrow to attach to the material and grow new bone...
Source: Health News from Medical News Today - February 12, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Become an Advocate for Science: Join the AIBS Legislative Action Center
Quick, free, easy, effective, impactful! Join the AIBS Legislative Action Center today! (www.aibs.org/public-policy/legislativeactioncenter.html) The AIBS Legislative Action Center is an online resource that allows biologists and science educators to quickly and effectively influence policy and public opinion. Each day lawmakers must make tough decisions about science policy. For example, what investments to make in federal research programs, how to conserve biodiversity, how to mitigate climate change, or under what circumstances to permit stem cell research. Scientists now have the opportunity to help elected officials ...
Source: Public Policy Reports - February 12, 2013 Category: Biology Authors: AIBS Source Type: news

Histopathological study of the treatment of melasma lesions using a low‐fluence Q‐switched 1064‐nm neodymium:yttrium–aluminium–garnet laser
Summary The low‐fluence 1064‐nm Q‐switched neodymium:yttrium–aluminium–garnet (QSNY) laser is a widely used treatment for melasma in East Asia, although its mechanism of action is unclear. The aim of this study was to elucidate the mechanism of action of the QSNY laser. We performed a histopathological study on eight Korean women who had considerable improvement in their melasma lesions after a series of low‐fluence QSNY laser treatments. Compared with nonlesional skin, samples from melasma lesions showed increased reactivity in melanin (Fontana–Masson staining) and in melanogenesis‐associated proteins, inc...
Source: Clinical And Experimental Dermatology - February 12, 2013 Category: Dermatology Authors: J. E. Kim, S. E. Chang, U. C. Yeo, S. Haw, I.‐H. Kim Tags: Concise report Source Type: research

Epigenetics: Epigenomics road map
Nature Reviews Genetics 14, 152 (2013). doi:10.1038/nrg3438 Author: Hannah Stower Here, histone modification maps for 29 human tissues and cell types, including stem cells, were obtained by chromatin immunoprecipitation followed by high-throughput sequencing (ChIP–seq). The authors used these maps to identify enhancers and other distal regulatory elements to an unprecedented scale across different developmental stages.
Source: Nature Reviews Genetics - February 12, 2013 Category: Genetics & Stem Cells Authors: Hannah Stower Tags: Research Highlight Source Type: research

Mesenchymal stem cells from amnion and amniotic fluid in bovine.
This study contributes to reinforce the emerging importance of these cells as ideal tools in veterinary medicine. A deeper evaluation of the immunological properties needs to be performed in order to better understand their role in cellular therapy. PMID: 23404849 [PubMed - as supplied by publisher]
Source: Reproduction - February 12, 2013 Category: Reproduction Medicine Authors: Corradetti B, Meucci A, Bizzaro D, Cremonesi F, Lange-Consiglio A Tags: Reproduction Source Type: research

Cyclooxygenase-2 dependent metabolism of 20-HETE increases adiposity and adipocyte enlargement in mesenchymal stem cell-derived adipocytes [Research Articles]
This study was designed to examine the effects of exogenous 20-HETE on mesenchymal stem cell (MSC)-derived adipocytes. The expression levels of CYP4A11 and CYP4F2 (major 20-HETE synthases in humans) in MSCs decreased during adipocyte differentiation; however, exogenous administration of 20-HETE (0.1–1 μM) increased adipogenesis in a dose-dependent manner in these cells (P < 0.05). The inability of a 20-HETE analog to reproduce these effects suggested the involvement of a metabolic product of 20-HETE in mediating its pro-adipogenic effects. A cyclooxygenase (COX)-1 selective inhibitor enhanced, whereas a COX-2 s...
Source: The Journal of Lipid Research - February 12, 2013 Category: Lipidology Authors: Kim, D. H., Puri, N., Sodhi, K., Falck, J. R., Abraham, N. G., Shapiro, J., Schwartzman, M. L. Tags: Research Articles Source Type: research

Mesenchymal Stem Cells Overexpressing C‐X‐C Chemokine Receptor Type 4 Improve Early Liver Regeneration of Small‐for‐Size Liver Grafts
In this study, we investigated whether a CXCR4‐MSC infusion could protect hepatocytes and stimulate regeneration in 50% reduced size liver transplantation (RSLT). Rats that underwent 50% RSLT were randomly divided into 3 groups: a phosphate‐buffered solution group (PBS), a green fluorescent protein (GFP)–MSC group, and a CXCR4‐MSC group. Rats received 1 mL of PBS with or without a resuspension of GFP‐MSCs or CXCR4‐MSCs. The factors secreted by MSCs, the graft function, the apoptosis and proliferation of hepatocytes, the efficacy of MSC engraftment, and the expression of SDF1α, albumin (Alb), and cytokeratin 18...
Source: Liver Transplantation - February 12, 2013 Category: Transplant Surgery Authors: Zhiyong Du, Cuifeng Wei, Jiqi Yan, Baosan Han, Mingjun Zhang, Chenghong Peng, Yingbin Liu Tags: Original Article Source Type: research

Wnt1/3a and Wnt5a cooperate in DA neuron development [Neuroscience]
Wnts are a family of secreted proteins that regulate multiple steps of neural development and stem cell differentiation. Two of them, Wnt1 and Wnt5a, activate distinct branches of Wnt signaling and individually regulate different aspects of midbrain dopaminergic (DA) neuron development. However, several of their functions and interactions remain to...
Source: Proceedings of the National Academy of Sciences - February 12, 2013 Category: Science Authors: Andersson, E. R., Salto, C., Villaescusa, J. C., Ca&jnodot;anek, L., Yang, S., Bry&jnodot;ova, L., Nagy, I. I., Vainio, S. J., Ramirez, C., Bry&jnodot;a, V., Arenas, E. Tags: PNAS Plus Source Type: research

Survival of myeloma patients following the introduction of thalidomide as a second‐line therapy: a retrospective study at a single New Zealand centre
ConclusionsThe front‐line treatment groupings of hospital MM patients had significantly different survivals. The OS of SCT ineligible patients remains poor despite the introduction of thalidomide.
Source: Internal Medicine Journal - February 12, 2013 Category: Internal Medicine Authors: L. J. Fernyhough, B. D. Hock, J. Taylor, J. Pearson, P. Ganly Tags: Original Article Source Type: research

Metabolic reprogramming as a novel regulator of skeletal muscle development and regeneration
Abstract Adult skeletal muscle contains a resident population of stem cells, termed satellite cells, that exist in a quiescent state. In response to an activating signal (such as physical trauma), satellite cells enter the cell‐cycle and undergo multiple rounds of proliferation, followed by differentiation, fusion and maturation. Over the last 10‐15 years, our understanding of the transcriptional regulation of this stem cell population has exploded, but there remains a dearth of knowledge in regards to the initiating signal leading to these changes in transcription. The recent renewed interest in the metabolic regulati...
Source: FEBS Journal - February 12, 2013 Category: Research Authors: James G. Ryall Tags: Review Article Source Type: research

LCNDG Rapid Review: Bortezomib for first-line, transplant unsuitable multiple myeloma
Source: London Cancer New Drugs Group Area: Evidence > Drug Specific Reviews There are no trials directly comparing bortezomib, melphalan, and prednisolone versus thalidomide-based regimens in patients with multiple myeloma who are not able to receive high-dose therapy and stem cell transplant. The phase III open-label randomised control trial investigating melphalan-prednisolone (control arm) against bortezomib-melphalan-prednisolone (bortezomib arm) reported a median time to progression of 24 months in the bortezomib arm and 16.6 months in the control arm (hazard ratio 0.48; P<0.001). The response cou...
Source: NeLM - Drug Specific Reviews - February 12, 2013 Category: Drugs & Pharmacology Source Type: news

Discovering cell surface proteins' behavior
(Simon Fraser University) A Simon Fraser University chemist is the lead author on a new paper that advances scientific understanding of the structure and function of glycoproteins, in particular the number and positioning of sugars on them.PLOS ONE, an international, peer-reviewed, open-access, online, scientific research journal, has just published the paper, N-glycoproteome of E14.Tg2a Mouse Embryonic Stem Cells.Glycoproteins are membrane proteins and are often involved in human diseases. They facilitate communication between cells.
Source: EurekAlert! - Medicine and Health - February 12, 2013 Category: Global & Universal Source Type: news

Motility imaging via optical coherence phase microscopy enables label‐free monitoring of tissue growth and viability in 3D tissue‐engineering scaffolds
Abstract As the field of tissue engineering continues to progress, there is a deep need for non‐invasive, label‐free imaging technologies that can monitor tissue growth and health within thick three‐dimensional (3D) constructs. Amongst the many imaging modalities under investigation, optical coherence tomography (OCT) has emerged as a promising tool, enabling non‐destructive in situ characterization of scaffolds and engineered tissues. However, the lack of optical contrast between cells and scaffold materials using this technique remains a challenge. In this communication, we show that mapping the optical phase flu...
Source: Journal of Tissue Engineering and Regenerative Medicine - February 12, 2013 Category: Molecular Biology Authors: Christina Holmes, Maryam Tabrizian, Pierre O. Bagnaninchi Tags: Short Communication Source Type: research

Broken Bones Mended With Stem Cells And Plastic
New bone tissue grown from patients' own stem cells that attach themselves to an implanted, rigid lightweight plastic "scaffolding" which gradually degrades and is replaced as new bone grows, could soon be healing shattered limbs, according to a new research report. The degradable polymer material is the result of a seven-year collaboration between the Universities of Southampton and Edinburgh. The researchers report their work in a paper published in the journal Advanced Functional Materials...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Bones / Orthopedics Source Type: news

Stem cells in current paediatric dentistry practice
Abstract: New protocols for regenerative endodontic treatment along with the parallel development of tissue engineering technologies are changing traditional knowledge and treatment possibilities for young patients with pulp-affected permanent immature teeth. The regeneration and completion of apical root development in pathological situations such as these is a clinical challenge that traditional treatments have not so far been able to resolve with complete success. In clinical terms, the decision of whether to perform apexogenesis or apexification on an immature tooth is determined by whether the pulp tissue is vital or ...
Source: Archives of Oral Biology - February 11, 2013 Category: Dentistry Authors: Alejandro Iglesias-Linares, Rosa-María Yáñez-Vico, Elena Sánchez-Borrego, Ana María Moreno-Fernández, Enrique Solano-Reina, Asunción Mendoza-Mendoza Tags: Review Source Type: research

Stem Cell Discovery Gives Insight Into Motor Neurone Disease
A discovery using stem cells from a patient with motor neurone disease could help research into treatments for the condition. The study used a patient's skin cells to create motor neurons - nerve cells that control muscle activity - and the cells that support them called astrocytes. Researchers studied these two types of cells in the laboratory. They found that a protein expressed by abnormalities in a gene linked to motor neurone disease, which is called TDP-43, caused the astrocytes to die...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Muscular Dystrophy / ALS Source Type: news

Prospective Surveillance for Invasive Fungal Infections (IFIs) in Hematopoetic Stem Cell (HSCTs) and Solid Organ Transplant Recipients (SOTs) in the United States
P.G. Pappas 1 , J. MORGAN , R.A. HAJJEH
Source: The Aspergillus Website - articles - February 11, 2013 Category: Respiratory Medicine Source Type: news

Distinct clinical features of infectious complications in adult T-cell leukemia/lymphoma patients after allogeneic hematopoietic stem cell transplantation: a retrospective analysis in the Nagasaki Transplant Group
Itonaga H, Taguchi J, Fukushima T, Tsushima H, Sato S, Ando K, Sawayama Y, Matsuo E, Yamasaki R, Onimaru Y, Imanishi D, Imaizumi Y, Yoshida S, Hata T, Moriuchi Y, Honda S, Miyazaki Y
Source: The Aspergillus Website - articles - February 11, 2013 Category: Respiratory Medicine Source Type: news

Stem Cells Show Promise In Extending Transplanted Kidneys' Survival Time
Can stem cells provide an answer to the perplexing question of how to ensure long-term survival of transplanted kidneys? The results of a new Phase 1 clinical trial say maybe so. Details of the trial, conducted by researchers at Leiden University Medical Center, The Netherlands, are published in the current issue of STEM CELLS Translational Medicine. Kidney transplants have long been the treatment of choice for many patients with end-stage renal disease, and the short-term results are excellent...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

New Freezing Procedure Increases Availability Of Cord Blood Stem Cell Transplants For Patients
A large enough number of stem cells are needed to ensure the success of a cord blood transplant. However, the quantity of stem cells isolated from umbilical cord blood is not always sufficient to meet that requirement. Researchers from the Etablissement FranÃ§ais du Sang, Aquitaine-Limousin (France) have established a method to multiply cord blood stem cells to required quantity levels. In the current study Dr...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Key Protein Revealed As Trigger For Stem Cell Development
A natural trigger that enables stem cells to become any cell type in the body has been discovered by scientists. Â� Researchers have identified a protein that kick-starts the process by which stem cells can develop to into different cells in the body, for instance liver or brain cells. Â� Their discovery could help scientists improve techniques enabling them to turn stem cells into other cell types in the laboratory...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Stem Cell Research Source Type: news

Researchers Uncover Key To Antidepressant Response
Through a series of investigations in mice and humans, Johns Hopkins researchers have identified a protein that appears to be the target of both antidepressant drugs and electroconvulsive therapy. Results of their experiments explain how these therapies likely work to relieve depression by stimulating stem cells in the brain to grow and mature. In addition, the researchers say, these experiments raise the possibility of predicting individual people's response to depression therapy, and fine-tuning treatment accordingly...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Depression Source Type: news

Study Using Cells Forged From Human Skin Shows Promise In Treating MS, Myelin Disorders
A study out today in the journal Cell Stem Cell shows that human brain cells created by reprogramming skin cells are highly effective in treating myelin disorders, a family of diseases that includes multiple sclerosis and rare childhood disorders called pediatric leukodystrophies. The study is the first successful attempt to employ human induced pluripotent stem cells (hiPSC) to produce a population of cells that are critical to neural signaling in the brain. In this instance, the researchers utilized cells crafted from human skin and transplanted them into animal models of myelin disease...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Potential Target Identified For Age-Related Cognitive Decline
As the elderly age, their ability to concentrate, reason, and recall facts tends to decline in part because their brains generate fewer new neurons than they did when they were younger. Now, researchers reporting in the Cell Press journal Cell Stem Cell have discovered a molecule that accumulates with age and inhibits the formation of new neurons. The finding might help scientists design therapies to prevent age-related cognitive decline. The investigators identified the molecule, called Dickkopf-1 or Dkk1, in the brains of aged mice...
Source: Health News from Medical News Today - February 11, 2013 Category: Consumer Health News Tags: Seniors / Aging Source Type: news

Characterization of a chip-based bioreactor for three-dimensional cell cultivation via magnetic resonance imaging.
We describe the characterization of a chip-based platform (3(D)-KITChip) for the three-dimensional cultivation of cells under perfusion conditions via magnetic resonance imaging (MRI). Besides the chip, the microfluidic system is comprised of a bioreactor housing, a medium supply, a pump for generating active flow conditions as well as a gas mixing station. The closed circulation loop is ideally suited for a characterization via MRI since the small bioreactor setup with active perfusion, driven by the pump from outside the coils, not only is completely MRI-compatible but also can be transferred into the magnetic coil of an...
Source: Zeitschrift fur Medizinische Physik - February 11, 2013 Category: Radiology Authors: Gottwald E, Kleintschek T, Giselbrecht S, Truckenmüller R, Altmann B, Worgull M, Döpfert J, Schad L, Heilmann M Tags: Z Med Phys Source Type: research

Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro.
In this study, rat embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) were co-cultured with granulosa cells (GCs) to differentiate to GC-like cells. The level of estradiol (E2) analyzed by radioimmunoassay showed that the E2 concentration of the culture supernatant of co-cultured rat iPSCs and ESCs increased in a time-dependent manner, compared with the GCs group that has an opposite trend. The expression of follicle-stimulating hormone receptor (FSHR) was confirmed by immunostaining. These results indicated that rat iPSCs and ESCs were effectively induced to GC-like cells through indirect cell-to-cell ...
Source: Acta Biochimica et Biophysica Sinica - February 11, 2013 Category: Biochemistry Authors: Zhang J, Li H, Wu Z, Tan X, Liu F, Huang X, Fang X Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

MicroRNA-153 is tumor suppressive in glioblastoma stem cells.
Abstract Glioblastoma multiforme (GBM) is lethal brain tumor thought to arise from GBM stem cells (GBM-SCs). MicroRNAs carry out post-transcriptional regulation of various cellular processes that modulate the stemness properties of GBM-SCs. Here, we investigated the critical role of miR-153 in GBM-SCs. First, GBM-SCs were isolated from six GBM specimens. These GBM-SCs formed GBM spheres, expressed markers associated with neural stem cells, and possessed the capacity for self-renewal and multilineage differentiation. Then qRT-PCR analysis showed that miR-153 expression was down-regulated in GBM tissues relative to n...
Source: Molecular Biology Reports - February 11, 2013 Category: Molecular Biology Authors: Zhao S, Deng Y, Liu Y, Chen X, Yang G, Mu Y, Zhang D, Kang J, Wu Z Tags: Mol Biol Rep Source Type: research

Osteogenesis of human mesenchymal stem cells on micro-patterned surfaces
Osteogenic responses of human mesenchymal stromal cells (hMSCs) were compared on square-patterned, inverse square-patterned, and planar titanium, chromium, diamond-like carbon (DLC), and tantalum; hypothesis was that both the materials and patterns affect osteogenesis. Samples were produced using photolithography and physical vapor deposition. Early-marker alkaline phosphatase (ALP) and mid-markers, small body size and mothers against decapentaplegic-related protein-1 (SMAD1), runt-related transcription factor-2 (RUNX2), and osteopontin were studied using quantitative real-time polymerase chain reaction. ALP and hydroxyapa...
Source: Journal of Biomaterials Applications - February 11, 2013 Category: Materials Science Authors: Kaivosoja, E., Myllymaa, S., Takakubo, Y., Korhonen, H., Myllymaa, K., Konttinen, Y. T., Lappalainen, R., Takagi, M. Tags: Articles Source Type: research

GESTODIFFERENT: a Cytoscape plugin for the generation and the identification of gene regulatory networks describing a stochastic cell differentiation process
Summary: The characterization of the complex phenomenon of cell differentiation is a key goal of both systems and computational biology. GeStoDifferent is a Cytoscape plugin aimed at the generation and the identification of gene regulatory networks (GRNs) describing an arbitrary stochastic cell differentiation process. The (dynamical) model adopted to describe general GRNs is that of noisy random Boolean networks (NRBNs), with a specific focus on their emergent dynamical behavior. GeStoDifferent explores the space of GRNs by filtering the NRBN instances inconsistent with a stochastic lineage differentiation tree representi...
Source: Bioinformatics - February 11, 2013 Category: Bioinformatics Authors: Antoniotti, M., Bader, G. D., Caravagna, G., Crippa, S., Graudenzi, A., Mauri, G. Tags: SYSTEMS BIOLOGY Source Type: research

Stem cell science and regenerative medicine
Source: BioEssays - February 11, 2013 Category: Molecular Biology Authors: Patrick P. L. Tam, Martin F. Pera Tags: Editorial Source Type: research

BioEssays 3/2013
Epithelial to mesenchymal transition as a portal to stem cell characters embedded in gene networks. The cover image shows the mouse proepicardial organ (PEO) at 9.5 dpc highlighted by Wt1 expression (bright red, centre). Bridges formed to the myocardium are a prelude to migration of proepicardial cells over the surface of the heart to form the epicardium. On pages 191–200 Naisana Asli and Richard Harvey review epithelial to mesenchymal transition (EMT) from a newly emerging angle that repositions this historically well‐regarded process as central to stem cell character. The authors suggest that EMT is embedded within t...
Source: BioEssays - February 11, 2013 Category: Molecular Biology Tags: Cover Picture Source Type: research

Adoptive transfer of human gingiva‐derived mesenchymal stem cells ameliorates collagen‐induced arthritis VIA suppressing Th1 and Th17 and enhancing regulatory T cell differentiation
Conclusion.The role of GMSCs in controlling CIA pathology mostly depends upon CD39/CD73 signals and partially upon the induction of CD4+CD39+Foxp3+ Treg cells. GMSCs provide a promising approach for the treatment of autoimmune diseases. © 2013 American College of Rheumatology.
Source: Arthritis and Rheumatism - February 11, 2013 Category: Rheumatology Authors: Maogen Chen, Wenru Su, Xiaohong Lin, Zhiyong Guo, Julie Wang, Qunzhou Zhang, David Brand, Bernhard Ryffel, Jiefu Huang, Zhongmin Liu, Xiaoshun He, Anh D. Le, Song Guo Zheng Tags: Full Length Source Type: research

CD24 and CD44 in salivary gland pleomorphic adenoma and in human salivary gland morphogenesis: differential markers of glandular structure or stem cell indicators?
ConclusionPA and stem cells share the expression of CD24 and CD44; their value as neoplastic cells markers of multipotency or their implications in tumour behaviour is yet to be determined.© 2013 Blackwell Publishing Ltd
Source: Histopathology - February 11, 2013 Category: Pathology Authors: Renata Carolina Fraga Ianez, Claudia Malheiros Coutinho‐Camillo, Marcilei Elisa Buim, Clóvis Antônio Lopes Pinto, Fernando Augusto Soares, Silvia Vanessa Lourenço Tags: Original Article Source Type: research