Transplant Surgery 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
31124 records returned
Blood Pressure Measurements and Left Ventricular Mass Index in Hemodialysis Patients
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AbstractLeft ventricular hypertrophy (LVH) is the most frequent cardiac abnormality in hemodialysis (HD) patients. It is related to cardiovascular diseases and is an important risk factor for mortality in HD patients. Arterial hypertension is an established risk factor for LVH in HD patients. Inferior vena cava (IVC) diameter is a good indicator of circulating fluid volume; hypervolemia is an important pathogenetic factor of hypertension in HD patients. The purpose of our study was to evaluate possible association between LVH, IVC diameter, and different blood pressure (BP) measurements in HD patients. In the present study...
Source: Artificial Organs - February 6, 2012 Category: Transplant Surgery Authors: Robert EkartVojko KaničBreda Pečovnik‐BalonSebastjan BevcBenjamin DvoršakRadovan Hojs Source Type: research
Fifty Years of Work on the Artificial Placenta: Milestones in the History of Extracorporeal Support of the Premature NewbornEmail this article to a colleague.
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AbstractThe concept of an artificial placenta has been pursued in experimental research since the early 1960s. The principle has yet to be successfully implemented in neonatal care despite the constant evolution in extracorporeal life support technology and advancements in neonatal intensive care in general. For more than three decades, the physical dimensions of the required equipment necessitated pump‐driven circuits; however, recent advances in oxygenator technology have allowed exploration of the simpler and physiologically preferable concept of pumpless arteriovenous oxygenation. We expect that further miniaturizati...
Source: Artificial Organs - February 6, 2012 Category: Transplant Surgery Authors: Mark SchobererJutta ArensAnne LohrMatthias SeehaseReint K. JellemaJennifer J. CollinsBoris W. KramerThomas Schmitz‐RodeUlrich SteinseiferThorsten Orlikowsky Source Type: research
Laryngeal transplantation in minipigs: early immunological outcomes.Email this article to a colleague.
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Abstract
Despite recent tissue-engineering advances, there is no effective way of replacing all the functions of the larynx in those requiring laryngectomy. A recent clinical transplant was a success. Using quantitative immunofluorescence targeted at immunologically relevant molecules, we have studied the early (48 h and 1 week) immunological responses within larynxes transplantated between seven pairs of National Institutes of Health (NIH) minipigs fully homozygous at the major histocompatibility complex (MHC) locus. There were only small changes in expression of some molecules (relative to interindividual varia...
Source: Clinical and Developmental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: Birchall MA, Ayling SM, Harley R, Murison PJ, Burt R, Mitchard L, Jones A, Macchiarini P, Stokes CR, Bailey M Tags: Clin Exp Immunol Source Type: research
For Kidney Disease Patients, Goals For Blood Pressure May Be UnrealisticEmail this article to a colleague.
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An upward revision of the blood pressure numbers used to identify risk of end-stage renal disease (ESRD) might actually help doctors provide better care for their patients, said the authors of a study in patients with chronic kidney disease (CKD). The researchers found that systolic blood pressure - the "upper number" in a blood pressure reading - was the key variable. Current guidelines call for CKD patients to maintain a systolic pressure of 130/80 or lower in order to prevent ESRD, which is complete or almost complete kidney failure, leading to dialysis, kidney transplant, or death... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 4, 2012 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news
Abercrombie to sign organ transplant funding bill into lawEmail this article to a colleague.
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Hawaii lawmakers on Friday passed legislation for about $1.8 million in emergency funds for kidney and liver transplants in the state.
Gov. Neil Abercrombie plans to sign House Bill 608 into law on Saturday at The Queen's Medical Center.
The law will appropriate emergency funds, subject to private matching funds, for the transplants, as well as to support a chronic kidney disease management program.
Hawaii was left without an organ transplant center after the closure last month of Hawaii Medical Center East, which ran the state's only organ transplant program before it stopped taking patients in December... (Source: biz...
Source: bizjournals.com Health Care:Hospitals headlines - February 3, 2012 Category: Hospital Management Source Type: research
Six-Organ Transplant Girl Goes Home TodayEmail this article to a colleague.
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After 100 days in hospital and undergoing a complicated 6-organ transplant, 9-year-old Alannah Shevenell, from Maine, leaves Boston Children's Hospital today and goes home. Alannah has been treated for a rare form of cancer; an inflammatory myofibroblastic tumor continued to grow after all possible treatments failed, and was compromising her internal organs. A team of surgeons, led by Dr. Heung Bae Kim, the hospital's Pediatric Transplant Center director, performed the transplant procedure of Alannah's liver, spleen, pancreas, stomach, small intestine and esophagus... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news
Maine girl home after 6-organ transplantEmail this article to a colleague.
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Alannah Shevenell, 9, needed new stomach, liver, spleen, small intestine, pancreas, esophagus after all were squashed by tumor (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - February 3, 2012 Category: Consumer Health News Source Type: news
Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation.Email this article to a colleague.
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In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure.
PMID: 22293651 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 2, 2012 Category: Research Authors: Simic-Ogrizovic S, Bogavac-Stanojevic N, Vuckovic M, Dopsaj V, Giga V, Kravljaca M, Stosovic M, Lezaic V Tags: Tohoku J Exp Med Source Type: research
Medicare Pay Policy on Transplant Drugs SlammedEmail this article to a colleague.
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(MedPage Today) -- Medicare's failure to provide lifelong coverage for immunosuppressive therapy after kidney transplant is bad for patients and for the system's finances, two researchers argued. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - February 2, 2012 Category: Geriatrics Source Type: news
Study: Volume matters in high-risk orthotopic heart transplant patientsEmail this article to a colleague.
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Undergoing orthotopic heart transplantation at high-volume centers (those who perform more than 15 procedures per year) leads to better outcomes, according to a study published in the January issue of the Journal of Thoracic and Cardiovascular Surgery. It was found that high-risk patients who undergo transplants at low-volume centers had “exceedingly high” mortality rates; however, center volume mattered less for lower risk patients. (Source: Cardiovascular Business News)
Source: Cardiovascular Business News - February 2, 2012 Category: Cardiology Tags: Latest News Source Type: news
Ground-breaking six-organ transplant saves Alannah Shevenell, 9, from 'monster' tumourEmail this article to a colleague.
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Alannah Shevenell, 9, is recovering at her home in Maine after a ground-breaking six-organ transplant which gave her a new esophagus, liver, stomach, spleen, pancreas and small intestine. (Source: the Mail online | Health)
Source: the Mail online | Health - February 2, 2012 Category: Consumer Health News Source Type: news
Geography Over Need Is Putting Sicker Patients Needing Lung Transplant At Higher Risk Of DyingEmail this article to a colleague.
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The current system for allocating donated lungs based on proximity and not on need appears to decrease the potential benefits of lung transplantation and increase the number of patients who die waiting, researchers said at an annual meeting of thoracic surgeons in Fort Lauderdale, Fla... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news
Evaluation of metabolic syndrome after hematopoietic stem cell transplantation in children and adolescentsEmail this article to a colleague.
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ConclusionsThe prevalence of MS was 32%, which was significantly higher than in a healthy pediatric population. We recommend prolonged follow‐up for transplant recipients, coupled with enforcement of preventive measures, such as early diagnosis and encouragement of a healthy lifestyle. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 2, 2012 Category: Cancer & Oncology Authors: Claudia ParisLorena YatesPamela LamaAna J. ZepedaDaniela GutiérrezJulia Palma Tags: Research Article Source Type: research
Early viral load and recipient IL28B rs12979860 genotype are predictors for progression of hepatitis C after liver transplantationEmail this article to a colleague.
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AbstractThere have been few studies of detailed viral kinetics following liver transplantation (LT) and conflicting data have been reported on viral load and severity of recurrent hepatitis C virus (HCV) disease. This long‐term study aimed to examine (1) the impact of HCV RNA levels at specific points in time within the first year and (2) the influence of IL28B genotype on patient outcome and severity of recurrent HCV disease. Viral load was measured at week 2, 4, 12, 24 and 48 following LT and recipient / donor IL28B genotypes of 164 patients were determined. Cox‐regression analysis showed that viral load at week 2 wa...
Source: Liver Transplantation - February 2, 2012 Category: Transplant Surgery Authors: Ivo W. GraziadeiHeinz M. ZollerAnna SchloeglKarin NachbaurKarl‐Peter PfeifferWalter MarkGregor MikuzJohann PratschkeRaimund MargreiterWolfgang Vogel Tags: Original Article Source Type: research
Banff 2011 Meeting Report: New Concepts in Antibody‐Mediated RejectionEmail this article to a colleague.
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The 11th Banff meeting was held in Paris, France, from June 5 to 10, 2011, with a focus on refining diagnostic criteria for antibody‐mediated rejection (ABMR). The major outcome was the acknowledgment of C4d‐negative ABMR in kidney transplants. Diagnostic criteria for ABMR have also been revisited in other types of transplants. It was recognized that ABMR is associated with heterogeneous phenotypes even within the same type of transplant. This highlights the necessity of further refining the respective diagnostic criteria, and is of particular significance for the design of randomized clinical trials. A reliable phenot...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: M. MengelB. SisM. HaasR. B. ColvinP. F. HalloranL. C. RacusenK. SolezL. CendalesA. J. DemetrisC. B. DrachenbergC. F. FarverE. R. RodriguezW. D. WallaceD. Glotz Tags: Meeting Report Source Type: research
Deleterious Effect of CTLA4‐Ig on a Treg‐Dependent Transplant ModelEmail this article to a colleague.
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This study confirms the importance of the B7:CD28 pathway in Treg homeostasis in an in vivo transplant model and suggests that hCTLA4Ig therapy may be deleterious in circumstances where engraftment is dependent on Tregs. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: L. V. RiellaT. LiuJ. YangS. ChockT. ShimizuB. MfarrejI. BatalX. XiaoM. H. SayeghA. Chandraker Source Type: research
A Common Peripheral Blood Gene Set for Diagnosis of Operational Tolerance in Pediatric and Adult Liver TransplantationEmail this article to a colleague.
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To identify biomarkers of operational tolerance in pediatric and adult liver transplant recipients, transcriptional profiles were examined from 300 samples by microarrays and Q‐PCR measurements of blood specimens from pediatric and adult liver transplant recipients and normal tissues. Tolerance‐specific genes were validated in independent samples across two different transplant programs and validated by Q‐PCR. A minimal set of 13 unique genes, highly expressed in natural killer cells (p = 0.03), were significantly expressed in both pediatric and adult liver tolerance, irrespective of different clinical and demographi...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: L. LiL. J. WozniakS. RodderS. HeishA. TalisettiQ. WangC. EsquivelK. CoxR. ChenS. V. McDiarmidM. M. Sarwal Source Type: research
Acquired Antithrombin Type IIb Deficiency After Liver Transplantation: A Case ReportEmail this article to a colleague.
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A 3‐year‐old girl with multifocal hepatoblastoma was referred to our clinic for living‐donor liver transplantation, the patient's father being the donor. Pretransplant evaluation revealed that the father presented partial asymptomatic antithrombin (AT) deficiency, with no inherited AT deficiency found in the girl. The genetic testing showed an AT type IIb deficiency responsible for a defect in the heparin‐binding region of AT which is less thrombogenic but more common than the other AT qualitative defects. Her mother was ABO incompatible. Despite the thrombophilia on the father's side, transplantation was successfu...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: L. HougardyX. StephenneR. RedingE. SokalF. SmetsC. LambertC. Hermans Tags: Case Report Source Type: research
A New Diagnostic Algorithm for Antibody‐Mediated Microcirculation Inflammation in Kidney TransplantsEmail this article to a colleague.
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We studied the significance of microcirculation inflammation in kidney transplants, including 329 indication biopsies from 251 renal allograft recipients, who were mostly nonpresensitized (crossmatch negative). Glomerulitis (g) and peritubular capillaritis (ptc) were often associated with antibody‐mediated rejection (65% and 75%, respectively), but were also found in other diseases in the absence of donor‐specific antibody (DSA): T‐cell‐mediated rejection (ptc, g), glomerulonephritis (g) and acute tubular necrosis (ptc). To develop rules for reducing the nonspecificity of microcirculation inflammation and defining ...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: B. SisG. S. JhangriJ. RiopelJ. ChangD. G. de FreitasL. HidalgoM. MengelA. MatasP. F. Halloran Source Type: research
Role of Rapamycin‐Induced Autophagy in Pancreatic IsletsEmail this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: M. TanemuraH. NaganoK. TaniyamaW. KamiikeM. MoriY. Doki Tags: Letter to the Editor Source Type: research
A Risk‐Prediction Model for In‐hospital Mortality After Heart Transplantation in US ChildrenEmail this article to a colleague.
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We sought to develop and validate a quantitative risk‐prediction model for predicting the risk of posttransplant in‐hospital mortality in pediatric heart transplantation (HT). Children <18 years of age who underwent primary HT in the United States during 1999–2008 (n = 2707) were identified using Organ Procurement and Transplant Network data. A risk‐prediction model was developed using two‐thirds of the cohort (random sample), internally validated in the remaining one‐third, and independently validated in a cohort of 338 children transplanted during 2009–2010. The best predictive model had four categorical...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: C. S. AlmondK. GauvreauC. E. CanterS. K. RajagopalG. E. PierceyT. P. Singh Source Type: research
The Presence of Autophagy in Mammal Cells Should Be Interpreted CarefullyEmail this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: N. Pallet Tags: Letter to the Editor Source Type: research
Organ Donation and Moyamoya DiseaseEmail this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: E. Diaz‐GuzmanJ. M. NeltnerC. W. Hoopes Tags: Letter to the Editor Source Type: research
Impact of Sirolimus Duration on Hepatitis C Related Fibrosis Progression in Liver Transplant RecipientsEmail this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: M. KimM.P. CurryC. C. Rogers Tags: Letter to the Editor Source Type: research
Counting Small Hypointense Spots Confounds the Quantification of Functional Islet Mass Based on Islet MRIEmail this article to a colleague.
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Iron‐containing fragmented islets or free iron released from dying cells could confound the interpretation of MRI of iron nanoparticle‐labeled islets. Exclusion of small hypointense spots could be a useful strategy to avoid such artifact. We investigated whether this strategy could improve the estimation of functioning islet mass after islet transplantation. Using a rat syngeneic intraportal islet transplantation model, we quantitatively assessed the relationships between total area, number of hypointense spots on MRI that belong to each size quartile and glycemic control of the recipients. The total area of hypointens...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: J. H. KimS. M. JinS. H. OhS. LeeB. J. OhS. K. KimS. SuhJ. H. LeeH. S. JungM.‐S. LeeM.‐K. LeeK.‐W. Kim Tags: Brief Communication Source Type: research
Diagnostic Pathology: Kidney Diseases, by Robert ColvinEmail this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: M. Mengel Tags: Book Review Source Type: research
Endogenous Expansion of Regulatory T Cells Leads to Long‐Term Islet Graft Survival in Diabetic NOD MiceEmail this article to a colleague.
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Donor pancreatic lymph node cells (PLNC) protect islet transplants in Non‐obese diabetic (NOD) mice. We hypothesized that induced FoxP3+ regulatory T cells (Tregs) were required for long‐term islet engraftment. NOD or NOD.NON mice were treated with ALS (antilymphocyte serum) and transplanted with NOR islets +/–PLNC (5 × 107). In vivo proliferation and expansion of FoxP3+ Tregs was monitored in spleen and PLN from ALS‐ and ALS/PLNC‐treated recipient mice. Anti‐CD25 depletion was used to determine the necessity of Tregs for tolerance. FoxP3+ numbers significantly increased in ALS/PLNC‐treated recipients compar...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: Q. ShiJ. R. LeesD. W. ScottD. L. FarberS. T. Bartlett Source Type: research
Multivisceral Ex Vivo Surgery for Tumors Involving Celiac and Superior Mesenteric ArteriesEmail this article to a colleague.
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Abdominal tumors involving both roots of the celiac and superior mesenteric artery are deemed unresectable by conventional surgical methods. We performed three cases of multivisceral ex vivo surgery involving temporary removal of the entire abdominal viscera followed by vascular reconstruction, ex vivo tumor resection and autotransplantation of excised organs. We achieved a complete tumor resection with negative margins in all cases. All patients have survived with no tumor recurrence to date at 17‐, 27‐ and 38‐month follow‐up. Postoperative complications included diarrhea, sphincter of Oddi dysfunction and arteria...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: T. KatoS. J. LobrittoA. TzakisY. RavehP. R. SandovalM. MartinezL. GranowetterA. ArmasR. S. Brown, Jr.J. Emond Tags: Case Report Source Type: research
Early Metabolic Markers that Anticipate Loss of Insulin Independence in Type 1 Diabetic Islet Allograft RecipientsEmail this article to a colleague.
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In conclusion, AIRGLU is an early metabolic assay capable of anticipating loss of insulin independence at 1 year in T1D patients undergoing PIT and constitutes a valuable, simple and reliable method to follow patients after transplant. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: D. HirschJ. OdoricoJ. S. DanobeitiaR. AlejandroM. R. RickelsM. HansonN. RadkeD. BaidalD. HullettA. NajiC. RicordiD. KaufmanL. Fernandez Source Type: research
Role of Lentivirus‐Mediated Overexpression of Programmed Death‐Ligand 1 on Corneal Allograft SurvivalEmail this article to a colleague.
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To investigate the role of lentivirus‐mediated overexpression of programmed death‐ligand 1 (PD‐L1) on rat corneal allograft survival. A fully allogeneic rat cornea transplant model was used for in vivo studies. Lentiviral (LV) vectors are efficient tools for ex vivo genetic modification of cultured corneas. LV vector encoding for PD‐L1 (LV.PD‐L1) and LV vector encoding for eGFP (LV.eGFP, as control) were constructed and tested. PD‐L1 or eGFP expression was increased on corneal cells upon LV.PD‐L1 and LV.eGFP transduction, respectively. Both allogeneic controls and allogeneic LV.eGFP transduced corneas were un...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: M. NosovM. WilkM. MorcosM. CreggL. O’FlynnO. TreacyT. Ritter Tags: Brief Communication Source Type: research
Donor Brain Death Inhibits Tolerance Induction in Miniature Swine Recipients of Fully MHC‐Disparate Pulmonary AllograftsEmail this article to a colleague.
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We have previously shown that a short course of high‐dose tacrolimus induces long‐term tolerance to fully mismatched lung allografts procured from healthy MHC‐inbred miniature swine. Here, we investigate whether donor brain death affects tolerance induction. Four recipient swine were transplanted with fully mismatched lung grafts from donors that were rendered brain dead and mechanically ventilated for 4 h before procurement (Group 1). These recipients were compared to two control groups (Group 2: 4 h of donor ventilation without brain death [n = 5]; and Group 3: no donor brain death with <1 h of ventilation [n = ...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: A. J. MeltzerG. R. VeilletteA. AoyamaK. M. KimM. E. CochraneJ. C. WainJ. C. MadsenD. H. SachsB. R. RosengardJ. S. Allan Tags: Brief Communication Source Type: research
Three‐Year Outcomes From BENEFIT‐EXT: A Phase III Study of Belatacept Versus Cyclosporine in Recipients of Extended Criteria Donor KidneysEmail this article to a colleague.
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In conclusion, at 3 years after transplantation, immunosuppression with belatacept resulted in similar patient survival, graft survival and acute rejection, with better renal function compared with cyclosporine. As previously reported, PTLD and tuberculosis were the principal safety findings associated with belatacept in this study population. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: J. O. M. PestanaJ. M. GrinyoY. VanrenterghemT. BeckerJ. M. CampistolS. FlormanV. D. GarciaN. KamarP. LangR. C. ManfroP. MassariM. D. C. RialM. A. SchnitzlerS. VitkoT. DuanA. BlockM. B. HarlerA. Durrbach Source Type: research
Lung Transplantation in Patients with Prior Cardiothoracic Surgical ProceduresEmail this article to a colleague.
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The full spectrum of prior cardiothoracic procedures in lung transplant candidates and the impact of prior procedures on outcomes after lung transplantation (LTx) remain unknown, though the impact is considered to be large. Patients transplanted at our institution from 2004 to 2009 were identified (n = 554) and divided into two groups: patients who had undergone cardiothoracic surgical (CTS) procedures prior to LTx (n = 238) and patients who had not (non‐CTS: n = 316). Our primary endpoint was survival. Secondary endpoints included allograft function and the incidence of major complications including reexploration due to...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: N. ShigemuraJ. BhamaC. J. GriesT. KawamuraM. CrespoB. JohnsonD. ZaldonisJ. PilewskiY. ToyodaC. Bermudez Source Type: research
Circulating Antibody Free Light Chains and Risk of Posttransplant Lymphoproliferative DisorderEmail this article to a colleague.
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Posttransplant lymphoproliferative disorder (PTLD) is a major complication of solid‐organ transplantation. With human immunodeficiency virus infection (an analogous immunosuppressive state), elevated kappa and lambda immunoglobulin free light chains (FLCs) in peripheral blood are associated with increased risk of lymphoma. To assess the role of B‐cell dysfunction in PTLD, we measured circulating FLCs among Canadian transplant recipients, including 29 individuals with PTLD and 57 matched transplant recipients who were PTLD‐free. Compared with controls, PTLD cases had higher kappa FLCs (median 1.53 vs. 1.07 times upper...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: E. A. EngelsJ. PreiksaitisA. ZingoneO. Landgren Source Type: research
Multiple Hyperacute Rejections in the Absence
of Detectable Complement Activation in a Patient
with Endothelial Cell Reactive AntibodyEmail this article to a colleague.
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This case involves a 54‐year‐old patient with polycystic kidney disease and a history of hyperacute allograft rejections. Two previous compatible live donor transplants functioned immediately but failed within the first 12 h due to antibody‐injury. This patient was referred for a third transplant due to decreased vascular access and progressive hypotension from uremic autonomic dysfunction. He was broadly sensitized to HLA; however, a live donor was identified through kidney paired donation for whom he had no donor‐specific HLA antibody (HLA‐DSA). This patient received one plasmapheresis (PP) and intravenous immu...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: A. M. JacksonM. B. KupermanR. A. Montgomery Tags: Case Report Source Type: research
With Respect to Elderly Patients: Finding Kidneys in the Context of New Allocation ConceptsEmail this article to a colleague.
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The elderly have benefited from increased access to renal transplantation in recent years. New allocation concepts would shift distribution of kidneys to younger recipients, making expanded criteria and living donor kidneys more relevant for seniors. Current issues impacting expanded criteria donor kidney availability and living donor transplant opportunities for the elderly are explored. It is hoped that the kidney donor profile index will improve risk assessment and utilization of marginal kidneys. The usefulness of procurement biopsy remains controversial. Dual kidney transplantation and machine perfusion appear to be e...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: P. L. TsoW. A. DarM. L. Henry Tags: Minireview Source Type: research
Differential Expression of MicroRNAs During Allograft RejectionEmail this article to a colleague.
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MicrorRNA are small noncoding RNA molecules that regulate the posttranscriptional expression of target genes. In addition to being involved in many biologic processes, microRNAs are important regulators in innate and adaptive immune responses. Distinct sets of expressed microRNAs are found in different cell types and tissues and aberrant expression of microRNAs is associated with many disease states. MicroRNA expression was examined in a model of heterotopic heart transplantation by microarray analyses and a unique profile was detected in rejecting allogeneic transplants (BALB/c → C57BL/6) as compared to syngeneic transp...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: L. WeiM. WangX. QuA. MahX. XiongA. G. C. HarrisL. K. PhillipsO. M. MartinezS. M. Krams Source Type: research
Transhilar Passage in Right Graft Live Donor Liver Transplantation: Intrahilar Anatomy and Its Impact on Operative StrategyEmail this article to a colleague.
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The passage through the hilar plate during right graft live donor liver transplantation (LDLT) can have dangerous consequences for both donors and recipients. The purpose of our study was to delineate hilar transection and biliary reconstruction strategies in right graft LDLT, with special consideration of central and peripheral hilar anatomical variants. A total of 71 consecutive donors underwent preoperative three‐dimensional (3D) CT reconstructions and virtual 3D hepatectomies. A three‐modal hilar passage strategy was applied, and its impact on operative strategy analyzed. In 68.4% of cases, type I and II anatomical...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: A. RadtkeG. C. SotiropoulosE. P. MolmentiG. SgourakisT. SchroederS. BeckebaumH.‐O. PeitgenV. R. CicinnatiC. E. BroelschD. C. BroeringM. Malagó Source Type: research
Recipient IL28B Polymorphism Is an Important Independent Predictor of Posttransplant Diabetes Mellitus in Liver Transplant Patients with Chronic Hepatitis CEmail this article to a colleague.
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IL28B polymorphisms are strongly associated with response to treatment for HCV infection. IL28B acts on interferon‐stimulated genes via the JAK‐STAT pathway, which has been implicated in development of insulin resistance. We investigated whether IL28B polymorphisms are associated with posttransplant diabetes mellitus (DM). Consecutive HCV patients who underwent liver transplantation between 1–1995 and 1–2011 were studied. Genotyping of the polymorphism rs12979860 was performed on DNA collected from donors and recipients. Posttransplant DM was screened for by fasting blood glucoses every 1–3 months. Of 221 include...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: B. J. VeldtA. Duarte‐RojoA. J. ThompsonK. D. WattJ. K. HeimbachH. L. TillmannD. D. GoldsteinJ. G. McHutchisonM. R. Charlton Source Type: research
Sirolimus Conversion for Renal Dysfunction in Liver Transplant Recipients: The Devil Really Is in the Details…Email this article to a colleague.
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(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: G. J. McKennaJ. F. Trotter Tags: Editorial Source Type: research
Mechanisms of Alloimmunization and Subsequent Bone Marrow Transplantation Rejection Induced by Platelet Transfusion in a Murine ModelEmail this article to a colleague.
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For many nonmalignant hematological disorders, HLA‐matched bone marrow transplantation (BMT) is curative. However, due to lack of neoplasia, the toxicity of stringent conditioning regimens is difficult to justify, and reduced intensity conditioning is used. Unfortunately, current reduced intensity regimens have high rates of BMT rejection. We have recently reported in a murine model that mHAs on transfused platelet products induce subsequent BMT rejection. Most nonmalignant hematological disorders require transfusion support prior to BMT and the rate of BMT rejection in humans correlates with the number of transfusions g...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: S. R. PatelN. H. SmithL. KappJ. C. Zimring Source Type: research
Patient, Center and Geographic Characteristics
of Nationally Placed LiversEmail this article to a colleague.
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In conclusion, utilization of nationally placed livers is highly concentrated in very few centers, with no increased adjusted risk of graft loss. These findings provide the foundation for a more informed discussion about changing our current liver allocation and distribution policies. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: J. C. LaiJ. P. RobertsE. VittinghoffN. A. TerraultS. Feng Source Type: research
Donor‐Specific HLA Antibodies in a Cohort Comparing Everolimus with Cyclosporine After Kidney TransplantationEmail this article to a colleague.
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Donor‐specific HLA antibodies (DSA) have a negative impact on kidney graft survival. Therefore, we analyzed the occurrence of DSA and antibody‐mediated rejection (AMR) in patients from two prospective randomized trials in our center. At 3–4.5 months posttransplant 127 patients were randomized to continue cyclosporine or converted to everolimus therapy. The presence of DSA was prospectively assessed using Luminex assays. AMR was defined according to the Banff 2009 classification. Antibody screening was available in 126 patients with a median follow‐up of 1059 days. Seven out of 65 (10.8%) patients on cyclosporine de...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: L. LiefeldtS. BrakemeierP. GlanderJ. WaiserN. LachmannC. SchönemannB. ZukunftP. IlligensD. SchmidtK. WuB. RudolphH.‐H. NeumayerK. Budde Source Type: research
9-Year-Old Girl Heads Home After 6 Organ Transplant At Children’s HospitalEmail this article to a colleague.
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BOSTON (CBS) — A 9-year-old girl went back home to Maine Wednesday, three months after a groundbreaking multiple organ transplant at Children’s Hospital Boston.
WBZ NewsRadio 1030′s Mark Katic reports
Alannah Shevenell of Hollis underwent 14-and-a-half hours of surgery in October to remove an aggressive tumor and six organs – her stomach, pancreas, spleen, liver, small bowel and the esophagus.
The tumor had twisted around the organs, so they all had to be transplanted.
“They come together sort of as a cluster, so it’s almost like transplanting one big organ,” said Dr. Heung Bae Kim, the director...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 1, 2012 Category: Consumer Health News Authors: miketoole Tags: Daily Headlines Health Heard On WBZ NewsRadio 1030 Local Syndicated Local Watch Listen Alannah Shevenell CBS Boston donate life esophagus Hollis Ken MacLeod liver Maine Mark Katic organ transplant pancreas small bowel s Source Type: news
Children’s becomes first hospital in New England to complete six organ transplantEmail this article to a colleague.
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The cover of today’s Boston Globe features the beaming face of Alannah Shevenell, a 9 year-old who will be heading home to Maine this morning after a three-month stay at Children’s Hospital Boston.
For just under 100 days Alannah and her grandmother have been staying at Children’s while she received treatment for a rare and aggressive cancer that was compromising several of her internal organs. When all other treatments had failed, Heung Bae Kim, MD, director of Children’s Pediatric Transplant Center (PTC), suggested a multivisceral transplant that would remove Alannah’s tumor and replace the ...
Source: Thrive, Children's Hospital Boston - February 1, 2012 Category: Pediatrics Authors: Childrens Hospital Boston staff Tags: All posts Cancer Children's in the news Our patients’ stories Boston Globe Heung Bae Kim multivisceral transplant Pediatric Transplant Center (PTC) Source Type: news
9-Year-Old Girl Heading Home After 6 Organ Transplant At Children’s HospitalEmail this article to a colleague.
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BOSTON (AP) — A 9-year-old Maine girl is heading home after a groundbreaking multiple organ transplant at Children’s Hospital Boston.
Alannah Shevenell of Hollis underwent 14 hours of surgery in October to remove an aggressive tumor and to undergo a transplant of her stomach, pancreas, spleen, liver, small bowel and esophagus.
Hospital officials say it was the first known esophageal transplant in the world and the largest number of organs transplanted into a person at one time in New England.
Alannah was diagnosed with a rare former of cancer when she was 4. The tumor snaked and twisted itself around her internal o...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 1, 2012 Category: Consumer Health News Authors: miketoole Tags: Health Local News Alannah Shevenell CBS Boston donate life esophagus Hollis liver Maine organ transplant pancreas small bowel spleen stomach WBZ Source Type: news
Improved Kidney Transplant Survival In Mice; New Agent Likely To Speed Replacement Of Other OrgansEmail this article to a colleague.
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New research published online in the FASEB Journal details a new antibody, called "OPN-305" that may significantly improve survival outcomes for those receiving donated kidneys and other organs. OPN-305 works by preventing inflammation triggered by oxygen deprivation in the donated organ, allowing for better recovery after transplantation. Specifically, it binds to sensors on transplant tissue, called "toll-like receptors" or "TLR-2," in the circulating blood and turns off signals that provoke inflammation... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 1, 2012 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news
Salvaging kidneys with renal allograft compartment syndromeEmail this article to a colleague.
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SummaryRenal allograft compartment syndrome is an under recognized cause of early allograft dysfunction which can be reversed by early intervention. It occurs early after renal transplantation where closure of the anterior abdominal wall seems to compress the transplant in the limited retroperitoneal space. The literature about this syndrome in renal transplantation is sparse. Our report describes the diagnostic criteria and the management of two renal transplant recipients with this syndrome. Its diagnosis depends upon duplex vascular scan findings of reversed or absent diastolic flow in the renal vasculature in the absen...
Source: Transplant International - February 1, 2012 Category: Transplant Surgery Authors: Munish Kumar HeerPaul Raymond TrevillianDavid Bradley HardyAdrian Donald Hibberd Tags: CASE REPORT Source Type: research
ContentsEmail this article to a colleague.
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(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 1, 2012 Category: Transplant Surgery Tags: Frontmatter Source Type: research
Editorial BoardEmail this article to a colleague.
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(Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - February 1, 2012 Category: Transplant Surgery Tags: Frontmatter Source Type: research
