Transplant Surgery
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Health Insurers Frequently Misclassify Physicians as Low-Cost or High-Cost Providers, RAND Reports
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Health Insurers Frequently Misclassify Physicians as Low- or High-Cost Providers Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 18, 2010 Category: Transplant Surgery Tags: Business of Medicine Source Type: info
Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: Successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression
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Dohna-Schwake C, Fiedler M, Gierenz N, Gerner P, Ballauf A, Breddemann A, Läer S, Baba H. A, Hoyer P. F. Primary HHV 6 infection after liver transplantation with acute graft rejection and multi-organ failure: Successful treatment with a 2.5-fold dose of cidofovir and reduction of immunosuppression.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: HHV type 6 has been reported with enhanced pathogenicity in immunocompromised patients. Herein, we report about a two-yr-old girl who experienced primary HHV 6 infection after liver transplantation. She clinically presented with graft rejection and necrotic hep...
Source: Pediatric Transplantation - March 18, 2010 Category: Transplant Surgery Authors: C. Dohna-Schwake, M. Fiedler, N. Gierenz, P. Gerner, A. Ballauf, A. Breddemann, S. Läer, H. A. Baba, P. F. Hoyer Source Type: journals
Will Healthcare Reform Increase Medicaid Pay as Well as Enrollment?
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A proposed pay hike could persuade more physicians to see Medicaid patients, but this good intention, like others, has a big price tag. Medscape Medical News (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - March 17, 2010 Category: Transplant Surgery Tags: Business of Medicine Source Type: info
Isolated left-sided pulmonary edema caused by alemtuzumab (Campath®) during kidney transplantation
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We describe a case of intraoperative pulmonary edema following administration of alemtuzumab. A 22-year-old man underwent kidney transplantation and received alemtuzumab intraoperatively. To provide better surgical exposure for transplantation, the operation table was tilted to the right. At the end of 3.5-h uneventful procedure, a sudden oxygen desaturation was noted after the bed was flattened. The postoperative chest X-ray showed opacification of the entire left lung field. After 4 days of bi-level positive airway pressure treatment, the lung field was cleared. This case is unique in that pulmonary edema developed durin...
Source: Transplant International - March 17, 2010 Category: Transplant Surgery Authors: Benjamin Grable, Tetsuro Sakai Source Type: journals
Improved erectile function and sex hormone profiles in male Chinese recipients of kidney transplantation
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Conclusions: Successful kidney transplantation can significantly ameliorate ED in Chinese patients, especially in individuals with a shorter time on dialysis. Changes in sex hormone levels may contribute to this improvement in ED. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 17, 2010 Category: Transplant Surgery Authors: Li Chen Teng, Chang Xi Wang, Lizhong Chen Source Type: journals
Stable long-term renal function after pediatric liver transplantation
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Herlenius G, Hansson S, Krantz M, Olausson M, Kullberg-Lindh C, Friman S. Stable long-term renal function after pediatric liver transplantation.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: Long-term exposure to calcineurin inhibitors increases the risk of CKD in children after LT. The aims of this study were to study renal function by measuring GFRm before and yearly after LT, to describe the prevalence of CKD (stage III: GFR 30[ndash]60 mL/min/1.73 m2) and to investigate if age and underlying liver disease had an impact on long-term renal function. Thirty-six patients with a median age of 2.9 years...
Source: Pediatric Transplantation - March 17, 2010 Category: Transplant Surgery Authors: Gustaf Herlenius, Sverker Hansson, Marie Krantz, Michael Olausson, Carola Kullberg-Lindh, Styrbjörn Friman Source Type: journals
Hematopoietic stem cell transplantation in patients with severe congenital neutropenia: An analysis of 18 Japanese cases
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Oshima K, Hanada R, Kobayashi R, Kato K, Nagatoshi Y, Tabuchi K, Kato S; for the Hematopoietic Stem Cell Transplantation Committee of the Japanese Society of Pediatric Hematology. Hematopoietic stem cell transplantation in patients with severe congenital neutropenia: An analysis of 18 Japanese cases.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: We studied the outcome of allogeneic HSCT in patients with SCN. Between 1989 and 2005, 18 patients with SCN in Japan received HSCT for reasons other than malignant transformation, i.e., because of the lack of or a partial response to treatment with r-HuG-CSF. ...
Source: Pediatric Transplantation - March 17, 2010 Category: Transplant Surgery Authors: Koichi Oshima, Ryoji Hanada, Ryoji Kobayashi, Koji Kato, Yoshihisa Nagatoshi, Ken Tabuchi, Shunichi Kato Source Type: journals
The role of liver transplantation for pediatric epithelioid hemangioendothelioma
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(Source: Pediatric Transplantation)
Source: Pediatric Transplantation - March 17, 2010 Category: Transplant Surgery Authors: Jean-Bernard Otte, Arthur Zimmerman Source Type: journals
Beneficial effects of donor-specific transfusion on renal allograft outcome
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Conclusion: DST imposes a significant beneficial effect on the incidence of AR, DGF and graft function during the first post-transplantation year in transfusion-naïve patients receiving standard immunosuppression therapy. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 16, 2010 Category: Transplant Surgery Authors: Svetlana Jovičić, Visnja Ležaić, Ruzica Simonović, Ljubica Djukanović Source Type: journals
Long-term effect of rituximab in maintaining remission of recurrent and plasmapheresis-dependent nephrotic syndrome post-renal transplantation – Case report
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We describe the long-term effect of four unadjusted doses of 375 mg/m2 i.v. rituximab, given to a five and a half-yr-old, nephrectomized child with immediate recurrence of nephrotic syndrome post-transplantation and dependency from repeated PF. Rituximab was introduced at three months post-transplantation after performing 18 sessions of PF and development of established dependency of the disease from plasma exchange. Complete remission of proteinuria was achieved with four doses, and it was maintained during next eight months of follow-up. Complete B CD19 cell depletion was observed during four months after final dose, fol...
Source: Pediatric Transplantation - March 16, 2010 Category: Transplant Surgery Authors: Ryszard Grenda, Wioletta Jarmużek, Barbara Piątosa, Jacek Rubik Source Type: journals
Transurethral injection therapy with carbon-coated beads (Durasphere®) for treatment of recurrent pyelonephritis in kidney transplant patients with vesico-ureteral reflux to the allograft
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Conclusions: Transurethral injection therapy with Durasphere® is a safe and effective minimally invasive treatment option for KTx patients with recurrent RTP. A second treatment seems to be necessary in some cases. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 15, 2010 Category: Transplant Surgery Authors: Ioannis M. Antonopoulos, Affonso C. Piovesan, Renato Falci Jr, Hideki Kanashiro, Fernando J.A. Saito, William C. Nahas Source Type: journals
Acalculous candidal cholecystitis after pediatric transplant
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Grosser J, Solomon H, Sotelo-Avila C. Acalculous candidal cholecystitis after pediatric transplant.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: AAC caused by Candida is an uncommon entity usually seen in the critically ill. Here, we present the case of an 18-month-old renal transplant patient who developed candidal AAC during the post-operative period. Previous articles have addressed acalculous cholecystitis secondary to a variety of causes, or addressed a wide variety of Candida infections in the biliary tract, but this is the first discussion of cholecystitis caused by Candida without confounding...
Source: Pediatric Transplantation - March 15, 2010 Category: Transplant Surgery Authors: Jennifer Grosser, Harvey Solomon, Cirilo Sotelo-Avila Source Type: journals
Actor Kulvinder Ghir Joins Forces With Transplant Patients In New TV Campaign To Encourage More Asian Donors
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Established actor, Kulvinder Ghir has joined forces with NHS Blood and Transplant to lend further support to a new campaign designed to increase the number of people from BME communities on the NHS Organ Donor Register... (Source: Transplants / Organ Donations News From Medical News Today)
Source: Transplants / Organ Donations News From Medical News Today - March 12, 2010 Category: Transplant Surgery Tags: Transplants / Organ Donations Source Type: news
Frequent expression of C4d in hepatic graft-versus-host disease: Potential clue for diagnosis and distinguishing acute and chronic form.
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CONCLUSION: Humoral activation seems to play a rule in pathophysiology of hepatic, especially chronic GVHD.
PMID: 20230895 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - March 12, 2010 Category: Transplant Surgery Authors: Ali SA, Shah V, McKinnon R, Van Harn M, Janakiraman N Tags: Transpl Immunol Source Type: journals
Liver transplantation for unresectable hepatocellular carcinoma in patients without liver cirrhosis
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SummaryHepatocellular carcinoma (HCC) arising in noncirrhotic and nonfibrotic liver (NC-HCC) is a rare type of malignancy frequently found in healthy young individuals. Partial liver resection is the treatment of choice with expected 5-year survival rates between 40% and 70%. As a result of absence of any symptom, a considerable number of patients are diagnosed when the malignancy has progressed to an advanced stage and the tumor has turned already unresectable. Some other patients suffer from intrahepatic recurrence after previous liver resection that cannot be re-resected or locally ablated. In these situations, liver tr...
Source: Transplant International - March 12, 2010 Category: Transplant Surgery Authors: Hynek Mergental, Robert J. Porte Source Type: journals
Exchange living donor liver transplantation to overcome ABO incompatibility in adult patients
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In conclusion, an exchange donor program for adult LDLT appears to be a feasible modality for overcoming donor-recipient ABO incompatibility. Liver Transpl, 2010. © 2010 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - March 11, 2010 Category: Transplant Surgery Authors: Shin Hwang, Sung-Gyu Lee, Deok-Bog Moon, Gi-Won Song, Chul-Soo Ahn, Ki-Hun Kim, Tae-Yong Ha, Dong-Hwan Jung, Kwan-Woo Kim, Nam-Kyu Choi, Gil-Chun Park, Young-Dong Yu, Young-Il Choi, Pyoung-Jae Park, Hea-Seon Ha Source Type: journals
Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts
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Our group has shown that platelet inhibition with clopidogrel, an antagonist of the P2Y12 adenosine diphosphate receptor on platelets, reduced the formation of transplant arteriosclerosis. The aim of this study was to investigate whether a combination of cyclosporin or everolimus with clopidogrel has a beneficial effect on the development of transplant arteriosclerosis. Fully MHC mismatched C57Bl/6 (H2b) donor aortas were transplanted into CBA.J (H2k) recipients and mice received either clopidogrel alone (1 mg/kg/day) or in combination with cyclosporin (2 mg/kg/day) or everolimus (0.05 mg/kg/day). Grafts were analysed by h...
Source: Transplant International - March 11, 2010 Category: Transplant Surgery Authors: Sebastian Eckl, Christian Heim, Silke Abele-Ohl, Julia Hoffmann, Martina Ramsperger-Gleixner, Michael Weyand, Stephan M. Ensminger Source Type: journals
Refractory insulin allergy: pancreas transplantation or immunosuppressive therapy alone?
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(Source: Transplant International)
Source: Transplant International - March 11, 2010 Category: Transplant Surgery Authors: Jacqueline Léonet, Jacques Malaise, Jean-Paul Squifflet Source Type: journals
Improvement in late renal allograft survival between 1990 and 2002 in Spain: results from a multicentre case–control study
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Epidemiological studies have failed to show an improvement in graft survival beyond 1 year after kidney transplantation possibly because of an increased number of expanded donors and older recipients. Thus, we performed a case[ndash]control study matching patients transplanted in different eras by donor and recipient characteristics. We considered renal transplant recipients included in the database of the Spanish Chronic Allograft Dysfunction Study Group in 1990, 1994, 1998 and 2002 (n = 4842). We matched patients from these cohorts considering the following variables: donor and recipient age, cause of donor death, hepati...
Source: Transplant International - March 11, 2010 Category: Transplant Surgery Authors: Francesc Moreso, Angel Alonso, Miguel A Gentil, Miguel González-Molina, Lluis Capdevila, Roberto Marcén, Julio Pascual, Daniel Serón Source Type: journals
Preparation of in-vivo tissue-engineered valved conduit with the sinus of Valsalva (type IV biovalve)
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Abstract A novel autologous valved conduit with the sinus of Valsalva—defined as a type IV biovalve—was created in rabbits by “in-body
tissue-architecture” technology with a specially designed mold for the valve leaflets and the sinus of Valsalva and a microporous
tubular scaffold for the conduit. The mold included 2 rods composed of silicone substrates. One was concave shaped, with 3
projections resembling the sinus of Valsalva; the other was convex shaped. The connection between the rods was designed to
resemble the closed form of a trileaflet valve. The 2 rods were connected with a small aperture ...
Source: Journal of Artificial Organs - March 10, 2010 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: journals
Microwave sterilization of bovine pericardium for heart valve applications
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Abstract It is widely recognised that the bioprosthetic valves widely used for heart valve replacements have some drawbacks, for example
tearing and occurrence of infections, which can be attributed to the fixation and sterilization techniques currently available.
These techniques adversely affect the physical properties, functionality, and lifespan of the leaflets. In the work discussed
in this paper we examined a novel procedure of using high-frequency microwaves to fix and disinfect the pericardium, without
causing any harmful affects. The test bacteria used were Escherichia coli and Staphylococcus aureus...
Source: Journal of Artificial Organs - March 10, 2010 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: journals
Prevention of oxidative stress in porcine islet isolation
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Abstract High yields of pure and viable porcine islet cells (PICs) to be used for microencapsulation are crucial for successful xenotransplantation.
Mechanical disruption of the pancreas, enzymes used for digestion, digestion temperature and time are among the factors known
to cause oxidative stress and to impact on the yield, purity and viability of PICs. The aim of our study was to optimize conventional
procedures in order to minimize the oxidative stress that occurs during the isolation and purification of PICs. Porcine pancreatic
tissue was harvested at a local slaughterhouse, and 15 consecutive isolatio...
Source: Journal of Artificial Organs - March 10, 2010 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: journals
New Hope To Vitiligo Patients Offered By Skin Transplant
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In the first study of its kind in the United States, Henry Ford Hospital showed that skin transplant surgery is safe and effective for treating vitiligo. Henry Ford researchers followed 23 patients for up to six months after surgery and found that the treated area regained on average 52 percent of its natural skin color... (Source: Transplants / Organ Donations News From Medical News Today)
Source: Transplants / Organ Donations News From Medical News Today - March 10, 2010 Category: Transplant Surgery Tags: Dermatology Source Type: news
Six months anti-viral prophylaxis significantly decreased cytomegalovirus disease compared with no anti-viral prophylaxis following renal transplantation
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We followed up 550 primary kidney transplant recipients in an observational retrospective cohort to evaluate the impact of three consecutive cytomegalovirus (CMV) prevention strategies. In period 1 (1996[ndash]2000; n = 190), no anti-CMV prophylaxis was given; in period 2 (2000[ndash]2004; n = 173), 6-month valacyclovir was given and in period 3 (>2004; n = 187), 6-month valganciclovir was given. Cytomegalovirus disease significantly decreased from 33.2% in period 1 to 13.9% in period 2 and to 8.6% in period 3; onset was significantly prolonged with valganciclovir (228 days) compared with valacyclovir (93 days) and with no...
Source: Transplant International - March 10, 2010 Category: Transplant Surgery Authors: Francesca Leone, Ahmed Akl, Magali Giral, Jacques Dantal, Gilles Blancho, Jean-Paul Soulillou, Diego Cantarovich Source Type: journals
Liver retransplantation in children: The Atlanta experience
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Heffron TG, Pillen T, Smallwood G, Henry S, Sekar S, Solis D, Casper K, Fasola C, Romero R. Liver retransplantation in children: The Atlanta experience.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: Liver retransplantation is routinely offered at our institution. Previous reports document that patient and graft survival is significantly less after pediatric rLT compared to primary LT. This has engendered intense debate regarding optimal allocation of organs. Here, we examine our program's approach to pediatric hepatic retransplantation related to patient factors affecting outcomes. Between 1997 and 20...
Source: Pediatric Transplantation - March 10, 2010 Category: Transplant Surgery Authors: Thomas G. Heffron, Todd Pillen, Gregory Smallwood, Stuart Henry, Sundari Sekar, David Solis, Katherine Casper, Carlos Fasola, Rene Romero Source Type: journals
Idiopathic pneumonia syndrome in mice after allogeneic bone marrow transplantation: Association between idiopathic pneumonia syndrome and acute graft-versus-host disease.
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CONCLUSIONS: The underlying cause of IPS is aGVHD. T cells and TNF-alpha may play a role in the pathogenesis of aGVHD-induced IPS. IPS progression may be associated with decreasing lung IFN-gamma levels.
PMID: 20226241 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - March 9, 2010 Category: Transplant Surgery Authors: Liu Q, Ning J, Zhang Y, Wu X, Luo X, Fan Z Tags: Transpl Immunol Source Type: journals
Gene expression analysis of Calcineurin isoforms in T-lymphocytes - a method applied on kidney-transplant recipients.
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CONCLUSION: We found no significant difference in the reference genes between the three groups, but looking at the data there was a trend towards an up-regulation of CD3E. PPIB appears to be the more stable of the two reference genes tested in our study.
PMID: 20226242 [PubMed - as supplied by publisher] (Source: Transplant Immunology)
Source: Transplant Immunology - March 9, 2010 Category: Transplant Surgery Authors: Mortensen DM, Røge R, Ozbay A, Koefoed-Nielsen PB, Jørgensen KA Tags: Transpl Immunol Source Type: journals
Expression of complement regulatory protein on porcine endogenous retrovirus (PERV) depends on molecular size.
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Expression of complement regulatory proteins (CRP) on pig cells is an effective means to avoid hyperacute rejection. However, pig endogenous retrovirus (PERV) from pig cells transfected with CRP may acquire resistance to human serum (HS). The present study investigated the size limitations of the transfected CRP that can be easily expressed and function on PERV particles. cDNAs of various sized DAF(CD55)s, including single-, double-, triple-, tetra-, as well as 2.1- and 2.2-DAF, were prepared. Pig endothelial cells (PEC) were transduced with the LacZ gene, and were then infected with PERV-B to produce PEC(Z)/PB. The ex...
Source: Transplant Immunology - March 9, 2010 Category: Transplant Surgery Authors: Yamamoto A, Kobayashi C, Yamashita S, Miyazawa T, Okabe M, Fukuzawa M, Miyagawa S Tags: Transpl Immunol Source Type: journals
Liver transplantation costs in the era of a health care crisis: Are we looking beyond and thinking about the economics?
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No abstract. (Source: Liver Transplantation)
Source: Liver Transplantation - March 9, 2010 Category: Transplant Surgery Authors: Mahmudul Haque Source Type: journals
Osteoporosis is a prevalent finding in patients with solid organ failure awaiting transplantation – a population based study
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Dolgos S, Hartmann A, Isaksen GA, Simonsen S, Bjørtuft Ø, Boberg KM, Bollerslev J. Osteoporosis is a prevalent finding in patients with solid organ failure awaiting transplantation [ndash] a population based studyClin Transplant 2010 DOI: 10.1111/j.1399-0012.2010.01231.x.© 2010 John Wiley & Sons A/S.Abstract: Post-transplant bone disease is common in solid organ recipients; however, there is limited information on their pre-transplant bone status. We aimed to compare bone mineral density (BMD) in different categories of patients with end-stage organ failure awaiting transplantation (Tx) in Norway. Overall 291 adult pati...
Source: Clinical Transplantation - March 9, 2010 Category: Transplant Surgery Authors: Szilveszter Dolgos, Anders Hartmann, Gunnhild Aker Isaksen, Svein Simonsen, Øystein Bjørtuft, Kirsten M. Boberg, Jens Bollerslev Source Type: journals
Indications, tolerance and complications of a sirolimus and calcineurin inhibitor immunosuppression regimen: Intermediate experience in pediatric heart transplantation recipients
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Matthews KL, Gossett JG, Vande Kappelle P, Jellen G, Pahl E. Indications, tolerance and complications of a sirolimus and calcineurin inhibitor immunosuppression regimen: Intermediate experience in pediatric heart transplantation recipients.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: Although SRL has been used in adults, few studies are reported in pediatric Htx recipients. Retrospective chart review of all Htx patients on SRL. We evaluated Cr at Htx and years 1, 3, 5, 7, 9, 11, 13, and 15 post-Htx. GFR was calculated (Schwartz). BMI, Hgb, lipid profiles, and complications were compared to 59 contro...
Source: Pediatric Transplantation - March 9, 2010 Category: Transplant Surgery Authors: Kathleen Matthews, Jeffrey Gossett, Peter Vande Kappelle, Gina Jellen, Elfriede Pahl Source Type: journals
Human herpes virus type 8-associated Kaposi sarcoma in a pediatric liver transplant recipient
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Çeltik C, Ünüvar A, Aydoğan A, Gökçe S, Öztürk G, Güllüoğlu M, Yılmaz G, Türkoğlu S, Anak S, Sökücü S, Durmaz Ö. Human herpes virus type 8-associated Kaposi sarcoma in a pediatric liver transplant recipient.Pediatr Transplantation 2010 © 2010 John Wiley & Sons A/S.Abstract: Development of KS in pediatric liver transplant recipients is a rare entity and has dismal prognosis. Latent HHV-8 infection, immunosuppression, and genetic predisposition are possible etiological factors. Decreasing the dose or cessation of immunosuppressive drugs, switching to sirolimus with antiproliferative...
Source: Pediatric Transplantation - March 8, 2010 Category: Transplant Surgery Authors: Coşkun Çeltik, Ayşegül Ünüvar, Ayşen Aydoğan, Selim Gökçe, Gülyüz Öztürk, Mine Güllüoğlu, Gülden Yılmaz, Salih Türkoğlu, Sema Anak, Semra Sökücü, Özlem Durmaz Source Type: journals
Severe novel H1N1 influenza A infection in the immediate postoperative period of a liver transplant patient
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In 2009, the World Health Organization recognized the novel H1N1 influenza A virus as a pandemic infection. Since April 2009, thousands of cases of novel H1N1 influenza A infection have been reported worldwide, and they have resulted in thousands of deaths. South American countries were affected by this infection during their winter season, and Chile presented one of the highest incidence rates. We have recently managed a liver transplant patient who presented with a severe novel H1N1 influenza A infection in the early postoperative period and required prolonged mechanical ventilation. The early suspicion of this infection...
Source: Liver Transplantation - March 5, 2010 Category: Transplant Surgery Authors: Rodrigo Zapata, Mario Uribe, Waldo Martínez, Alejandro Andrade, José Luis Leal, Fernando Gomez Source Type: journals
Autosomal dominant polycystic kidney disease: risk factor for nonmelanoma skin cancer following kidney transplantation
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Nonmelanoma skin cancers (NMSC) are the most common malignant tumors following solid organ transplantation. Risk factors for NMSC mainly include immunosuppression, age, sun exposure and patient phototype. Recent findings have suggested that autosomal dominant polycystic kidney disease (ADPKD) may increase the risk of developing NMSC. We performed a monocenter retrospective study including all kidney recipients between 1985 and 2006 (n = 1019). We studied the incidence of NMSC, solid cancers and post-transplantation lymphoproliferative disease (PTLD), and analyzed the following parameters: age, gender, phototype, time on di...
Source: Transplant International - March 5, 2010 Category: Transplant Surgery Authors: Anne Bretagnol, Jean Michel Halimi, Mélanie Roland, Christelle Barbet, Laurent Machet, Azmi Al Najjar, Jean Frédéric Marlière, Julie Badin, Hubert Nivet, Yvon Lebranchu, Matthias Büchler Source Type: journals
Potential functional and survival benefit of double over single lung transplantation for selected patients with idiopathic pulmonary fibrosis
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Idiopathic pulmonary fibrosis (IPF) is a frequent indication for lung transplantation (LTX) with pulmonary hypertension (PH) negatively affecting outcome. The optimal procedure type remains a debated topic. The aim of this study was to evaluate the impact of pretransplant PH in IPF patients. Single LTX (SLTX, n = 46) was the standard procedure type. Double LTX (DLTX, n = 30) was only performed in cases of relevant PH or additional suppurative lung disease. There was no significant difference for pretransplant clinical parameters. Preoperative mean pulmonary arterial pressure was significantly higher in DLTX recipients (22....
Source: Transplant International - March 5, 2010 Category: Transplant Surgery Authors: Claus Neurohr, Patrick Huppmann, Dolores Thum, Werner Leuschner, Werner von Wulffen, Tobias Meis, Hanno Leuchte, Rainer Baumgartner, Gregor Zimmermann, Rudolf Hatz, Stephan Czerner, Lorenz Frey, Peter Ueberfuhr, Iris Bittmann, Juergen Behr Source Type: journals
mTOR inhibitor-associated dermatologic and mucosal problems
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Campistol JM, de Fijter JW, Flechner SM, Langone A, Morelon E, Stockfleth E. mTOR inhibitor-associated dermatologic and mucosal problems.Clin Transplant 2010 DOI: 10.1111/j.1399-0012.2010.01232.x.© 2010 John Wiley & Sons A/S.Abstract: Mammalian target of rapamycin inhibitor use is associated with numerous adverse events, including dermatologic and mucosal problems. Awareness of these complications, which clinically manifest across a severity spectrum from minor through severe and may occur at varied time points after initiation of sirolimus therapy, can be useful to clinicians in both managing these events and determining...
Source: Clinical Transplantation - March 5, 2010 Category: Transplant Surgery Authors: Josep M. Campistol, Johan W. de Fijter, Stuart M. Flechner, Anthony Langone, Emmanuel Morelon, Eggert Stockfleth Source Type: journals
Long-term impact of respiratory viral infection after pediatric lung transplantation
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Liu M, Mallory GB, Schecter MG, Worley S, Arrigain S, Robertson J, Elidemir O, Danziger-Isakov LA. Long-term impact of respiratory viral infection after pediatric lung transplantation. Pediatr Transplantation 2010 00: 000[ndash]000. © 2010 John Wiley & Sons A/S.Abstract: To evaluate the epidemiology and to investigate the impact of RVI on chronic allograft rejection after pediatric lung transplantation, a retrospective study of pediatric lung transplant recipients from 2002 to 2007 was conducted. Association between RVI and continuous and categorical risk factors was assessed using Wilcoxon rank-sum tests and Fisher's exa...
Source: Pediatric Transplantation - March 5, 2010 Category: Transplant Surgery Authors: M. Liu, G. B. Mallory, M. G. Schecter, S. Worley, S. Arrigain, J. Robertson, O. Elidemir, L. A. Danziger-Isakov Source Type: journals
Living-donor lobar lung transplantation for interstitial pneumonia associated with dermatomyositis
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(Source: Transplant International)
Source: Transplant International - March 4, 2010 Category: Transplant Surgery Authors: Tsuyoshi Shoji, Toru Bando, Takuji Fujinaga, Kenichi Okubo, Naoichiro Yukawa, Tsuneyo Mimori, Hiroshi Date Source Type: journals
Dopamine as additive to cold preservation solution improves postischemic integrity of the liver
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Dopamine pretreatment has been used to confer protection against cellular injury following hypothermia or anoxia, especially in vascular endothelial cells. Ischemia/reperfusion-associated tissue alterations still represent a major drawback in liver transplantation. The present study was aimed to investigate the effect of dopamine as an ex vivo adjunct, added to the cold storage solution, on cold preservation of the liver. Rat livers were excised 30 min after cardiac arrest, flushed with preservation solution and cold stored for 18 h. Dopamine (10, 50 or 100 [mu]m) was added to the preservation solution in other livers. Org...
Source: Transplant International - March 4, 2010 Category: Transplant Surgery Authors: Martina Koetting, Judith Stegemann, Thomas Minor Source Type: journals
De novo membranous nephropathy and antibody-mediated rejection in transplanted kidney
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Conclusions: DSA and AMR might play some roles for the pathogenesis in some patients with de novo MN after kidney transplantation. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Kazuho Honda, Shigeru Horita, Daisuke Toki, Sekiko Taneda, Kosaku Nitta, Motoshi Hattori, Kazunari Tanabe, Satoshi Teraoka, Hideaki Oda, Yutaka Yamaguchi Source Type: journals
Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients
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Conclusion: Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Ming-Che Lee, Chung-Jen Lee, Guan-Jin Ho, Chia-Chi Lee, Ming-Hui Shih, Kuei-Chun Chou, Bang-Gee Hsu Source Type: journals
Who should have pelvic vessel imaging prior to renal transplantation?
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Subesinghe M, Cherukuri A, Ecuyer C, Baker RJ. Who should have pelvic vessel imaging prior to renal transplantation?Clin Transplant 2010 DOI: 10.1111/j.1399-0012.2010.01218.x.© 2010 John Wiley & Sons A/S.Abstract: Current guidelines are vague in their recommendations as to which patients should be imaged prior to renal transplantation and the optimal imaging modality for this purpose. Data on 112 patients who underwent pre-transplant vascular imaging (magnetic resonance angiography or contrast angiography), from a total of 167 evaluated between January 2005 and October 2006, were scrutinized to see whether abnormal result...
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Manil Subesinghe, Aravind Cherukuri, Clare Ecuyer, Richard James Baker Source Type: journals
Unique histopathological features of graft biopsies with liver function abnormalities in living donor liver transplant patients receiving basiliximab induction therapy
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Sato K, Sekiguchi S, Kawagishi N, Akamatsu Y, Ishida K, Fukushima D, Miyagi S, Takeda I, Yamaguchi M, Oguma S, Fujimori K, Sato A, Satomi S. Unique histopathological features of graft biopsies with liver function abnormalities in living donor liver transplant patients receiving basiliximab induction therapy.Clin Transplant 2010 DOI: 10.1111/j.1399-0012.2010.01219.x.© 2010 John Wiley & Sons A/S.Abstract: Induction with basiliximab (BXM) has been confirmed as an effective treatment regimen for prophylaxis of acute cellular rejection (ACR). From 1991 to 2008, 116 living donor liver transplantations (LDLTs) were performed. Am...
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Kazushige Sato, Satoshi Sekiguchi, Naoki Kawagishi, Yorihiro Akamatsu, Kazuyuki Ishida, Daizo Fukushima, Shigeto Miyagi, Ikuo Takeda, Masaaki Yamaguchi, Shirou Oguma, Keisei Fujimori, Akira Sato, Susumu Satomi Source Type: journals
Donor graft does not affect the P450 2C19 genotype expressed in peripheral blood in recipients of living donor liver transplantation
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This study aims to clarify the changes in CYP2C19 in the peripheral blood before and after LT. Thirty pairs of living donors and recipients were enrolled in this study. The CYP2C19 genotype in peripheral blood mononuclear cells (PBMCs) was studied immediately before operation in donors, on the day preceding the operation in the unstable recipients, and one month after LT in stable recipients. Limited data suggest that the post-LT genotype in liver biopsy is the same as donor's original genotype in most cases (80.0%) and that only 2 patients in the study cohort had the same liver tissue genotype as the respective recipient ...
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: King-Wah Chiu, Wei-Chen Tai, Toshiaki Nakano, Hui-Peng Tseng, Yu-Fan Cheng, Bruno Jawan, Shigeru Goto, Chao-Long Chen Source Type: journals
Choice of calcineurin inhibitor may influence the development of de novo immune hepatitis associated with anti-GSTT1 antibodies after liver transplantation
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In conclusion, the choice of calcineurin inhibitor may influence the development of de novo IH mediated by anti-GSTT1 antibodies. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Isabel Aguilera, Jose M. Sousa, Juan M. Praena, Miguel A. Gómez-Bravo, Antonio Núñez-Roldan Source Type: journals
Evaluation of living related kidney donors in China: policies and practices in a transplant center
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Conclusion: Although strongly forbidden by Chinese laws, organ trading remains a threat to the healthy development of LRDKT in China. To prohibit organ trading, the kinship between the donor and recipient should be carefully identified. Guidelines for living donor evaluation appropriate to the actual situation in China should be set up for the sake of safety and to protect the rights and interests of both donors and recipients. (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Wen-Yu Zhao, Lei Zhang, Shu Han, You-Hua Zhu, Li-Ming Wang, Mei-Sheng Zhou, Li Zeng Source Type: journals
Liver transplantation in patients aged 65 and over: a case–control study
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Discussion: Patients aged between 65 and 70 with low MELD score who undergo LT have the same short- and middle-term survival expectancy, morbidity, and outcome quality as younger patients with the same indication and same pre-LT pathology severity, whatever they might be. Thus, chronological age alone should not deter LT workup in patients >65 and (Source: Clinical Transplantation)
Source: Clinical Transplantation - March 4, 2010 Category: Transplant Surgery Authors: R. Montalti, G. Rompianesi, F. Di Benedetto, R. Ballarin, R. C. Gerring, S. Busani, L. De Pietri, N. De Ruvo, R. M. Iemmolo, G. P. Guerrini, N. Smerieri, G. E. Gerunda Source Type: journals
Low donor-to-recipient weight ratio does not negatively impact survival of pediatric heart transplant patients
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Tang L, Du W, Delius RE, L'Ecuyer JL, Zilberman MV. Low donor-to-recipient weight ratio does not negatively impact survival of pediatric heart transplant patients.Pediatr Transplantation 2010. © 2010 John Wiley & Sons A/S.Abstract: A major limitation to success in pediatric heart transplantation is donor organ shortage. While the use of allografts from donors larger than the recipient is accepted, the use of undersized donor grafts is generally discouraged. Using the UNOS database, we wanted to evaluate whether using smaller donor hearts affects the short- and long-term survival of pediatric heart transplant patients. A r...
Source: Pediatric Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Liwen Tang, Wei Du, Ralph E. Delius, Thomas J. L'Ecuyer, Mark V. Zilberman Source Type: journals
MHC class II deficiency cured by unrelated mismatched umbilical cord blood transplantation: Case report and review of 68 cases in the literature
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We report an eight-month-old boy presenting with severe respiratory infections and chronic diarrhea, whose sister died at the age of four yr from septicemia. MHC II deficiency was caused by an RFXANK-mutation and treated successfully by 4/6 mismatched unrelated CBT after a myeloablative conditioning regimen based on anti-thymocyte globulin, busulfane, fludarabine, and cyclophosphamide. At present, our patient is well with full immune reconstitution 3 yr after CBT. CB may represent an alternative source of stem cells for children with MHC class II deficiency without a suitable donor. (Source: Pediatric Transplantation)
Source: Pediatric Transplantation - March 4, 2010 Category: Transplant Surgery Authors: M. Siepermann, S. Gudowius, K. Beltz, U. Strier, O. Feyen, A. Troeger, U. Göbel, H. J. Laws, G. Kögler, R. Meisel, D. Dilloo, T. Niehues Source Type: journals
Liver transplantation in children with hyper-reduced grafts – A single-center experience
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We report our experience with hyper-reduction of adult left lateral segment grafts in nine children. A retrospective review of the medical records of children who received hyper-reduced grafts at the Children's Hospital at Westmead, Australia was performed. Of 215 liver transplants performed on 186 children between 1986 and May 2009, 147 were reduced grafts. Nine grafts were further reduced (hyper-reduced) after an on-table assessment of graft size relative to the available abdominal space was made. Mean graft size reduction was by 30%. The pledgetted technique of resection was used in four patients. All required delayed c...
Source: Pediatric Transplantation - March 4, 2010 Category: Transplant Surgery Authors: Naveen Thomas, Gordon Thomas, Deborah Verran, Michael Stormon, Edward O'Loughlin, Albert Shun Source Type: journals
