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This page shows you the most recent publications within this specialty of the MedWorm directory.

Breakthrough in human cloning raises hopes for treatment of Parkinson's and heart disease
Scientists have finally made the long-awaited breakthrough in human cloning by turning skin cells into early-stage embryos that were then used to create specialised tissue cells for transplant operations, it has been revealed today. (Source: The Independent - Science)
Source: The Independent - Science - May 15, 2013 Category: Science Tags: Health News Source Type: news

Human cloning breakthrough raises hopes for treatment of Parkinson's and heart disease
Scientists have finally made the long-awaited breakthrough in human cloning by turning skin cells into early-stage embryos that were then used to create specialised tissue cells for transplant operations, it has been revealed today. (Source: The Independent - Science)
Source: The Independent - Science - May 15, 2013 Category: Science Tags: Health News Source Type: news

Human cloning breakthrough raises hopes in treatment of Parkinson's and heart disease
Scientists have finally made the long-awaited breakthrough in human cloning by turning skin cells into early-stage embryos that were then used to create specialised tissue cells for transplant operations, it was revealed today. (Source: The Independent - Science)
Source: The Independent - Science - May 15, 2013 Category: Science Tags: Science Source Type: news

Robotic transplant an option for obese kidney patients
(University of Illinois at Chicago) Robotic kidney transplantation gives new hope to obese patients previously denied access to life-saving surgery. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2013 Category: Global & Universal Source Type: news

Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo
We examined lung function by blood gas analysis, extent of lung injury, and expression of HO-1. We also investigated the role of NF-E2-related factor (Nrf) 2, which regulates HO-1 expression, by examining the expression of Nrf2-dependent genes and the ability of hydrogen to reduce hyperoxic lung injury in Nrf2-deficient mice. Hydrogen treatment during exposure to hyperoxia significantly improved blood oxygenation, reduced inflammatory events, and induced HO-1 expression. Hydrogen did not mitigate hyperoxic lung injury or induce HO-1 in Nrf2-deficient mice. These findings indicate that hydrogen gas can ameliorate hyperoxic ...
Source: AJP: Lung Cellular and Molecular Physiology - May 15, 2013 Category: Respiratory Medicine Authors: Kawamura, T., Wakabayashi, N., Shigemura, N., Huang, C.-S., Masutani, K., Tanaka, Y., Noda, K., Peng, X., Takahashi, T., Billiar, T. R., Okumura, M., Toyoda, Y., Kensler, T. W., Nakao, A. Tags: ARTICLES Source Type: research

Four‐year allograft survival in a highly sensitized combined liver–kidney transplant patient despite unsuccessful anti‐HLA antibody reduction with rituximab, splenectomy, and bortezomib
Summary Although donor‐specific lymphocytotoxic antibodies are regarded as a contraindication for kidney transplantation (KTx), the data available for liver or combined liver or kidney transplantation (cLKTx) are scarce. Here, we report a case of a highly sensitized young man receiving his sixth liver and second kidney graft. Multiple anti‐HLA antibodies were present at the time of transplantation. As a result of suspected antibody‐mediated graft damage, the patient was treated with rituximab, plasmapheresis, intravenous immunoglobulins, splenectomy, and bortezomib to decrease the antibody production. So far, patient...
Source: Transplant International - May 15, 2013 Category: Transplant Surgery Authors: Martina Koch, Christian Gräser, Anja Lehnhardt, Jörg M. Pollok, Nikolaus Kröger, Murielle Verboom, Friedrich Thaiss, Thomas Eiermann, Björn Nashan Tags: Case Report Source Type: research

Increased incidence of herpes zoster in the setting of cytomegalovirus preemptive therapy after kidney transplantation
ConclusionsIn the setting of CMV preemptive therapy, a differentiated varicella zoster virus‐specific prophylaxis might be necessary for patients with HZ risk factors. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - May 15, 2013 Category: Transplant Surgery Authors: G.B. Ko, T. Kim, S.‐H. Kim, S.‐H. Choi, Y.S. Kim, J.H. Woo, Y.H. Kim, J.B. Park, S.K. Lee, S.‐K. Park, J.S. Park, D.J. Han, S.‐O. Lee Tags: Original Article Source Type: research

Turkish Womb Transplant Patient Loses BabyTurkish Womb Transplant Patient Loses Baby
A woman who was the first to have a successful womb transplant from a dead donor has had her pregnancy terminated after the embryo showed no heart beat, doctors in Turkey said. Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 14, 2013 Category: Consumer Health News Tags: Transplantation News Source Type: news

Turkish womb transplant patient loses baby
ISTANBUL (Reuters) - A woman who was the first to have a successful womb transplant from a dead donor has had her pregnancy terminated after the embryo showed no heart beat, doctors in Turkey said on Tuesday. (Source: Reuters: Health)
Source: Reuters: Health - May 14, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Star Career Academy Students Support Classmate With Long Island Kidney Walk Sponsorship
Star Career Academy students from the school's Long Island campus, will honor classmate Megan Reister, who had a failed kidney transplant at the age of 15 and family members who have survived kidney cancer...05/14/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 14, 2013 Category: Cancer & Oncology Source Type: news

A rare presentation of multiple primary squamous cell carcinoma of the tongue in a patient with recurrent hepatitis C infection
ABSTRACT Hepatitis C virus (HCV) infection has been implicated as a risk factor for development of oral squamous cell carcinoma (SCC). Multiple primary sites of oral SCC associated with HCV infection occurs infrequently. This case report describes a rare presentation of multiple primary SCCs of the tongue in a patient with recurrent HCV cirrhosis status post liver transplant that required interdisciplinary medical and surgical management. It is important for oral health care providers to understand the local and systemic implications of HCV infection and perform routine clinical examinations to monitor for development of o...
Source: Special Care in Dentistry - May 14, 2013 Category: Dentistry Authors: Eric T. Stoopler, Ying Wai Sia, Ara A. Chalian, Bert W. O'Malley, Faizan Alawi Tags: Case History Report Source Type: research

Imaging of Vascular Complications and Their Consequences Following Transplantation in the Abdomen [Multisystem Radiology]
This article includes a basic description of the standard surgical techniques performed in the abdomen, with emphasis on the relevant vascular anastomotic reconstructions used. Posttransplantation complications can be broadly classified as vascular or nonvascular in origin. Many of these complications can be accurately depicted and characterized at imaging and dealt with definitively by using interventional radiology techniques, which can be graft- and life-saving and can obviate further complex surgical intervention. The article discusses imaging appearances of vascular complications and their consequences after transplan...
Source: Radiographics recent issues - May 14, 2013 Category: Radiology Authors: Low, G., Crockett, A. M., Leung, K., Walji, A. H., Patel, V. H., Shapiro, A. M. J., Lomas, D. J., Coulden, R. A. Tags: Vascular Imaging, Gastrointestinal Radiology, General, Genitourinary Radiology Multisystem Radiology Source Type: research

Outcome of the sub-optimal dialysis starter on peritoneal dialysis. Report from the French Language Peritoneal Dialysis Registry (RDPLF)
Conclusions Sub-optimal dialysis initiation is neither associated with a higher risk of death nor with a lower risk of renal transplantation. Sub-optimal PD patients had a higher risk of transfer to HD. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Lobbedez, T., Verger, C., Ryckelynck, J.-P., Fabre, E., Evans, D. Tags: Intra- and Extracorporeal Treatment of Kidney Failure Source Type: research

A randomized controlled trial of exercise training on cardiovascular and autonomic function among renal transplant recipients
Conclusions The increased cardiorespiratory fitness by exercise training was associated with an improved BRS function and a modification of the sympathovagal control of HRV towards a persistent increase in parasympathetic tone. These alterations may lead to a better cardiovascular prognosis in RT recipients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: Kouidi, E., Vergoulas, G., Anifanti, M., Deligiannis, A. Tags: Renal Transplantation Source Type: research

Mortality in diabetes: pancreas transplantation is associated with significant survival benefit
Conclusions Type 1 diabetics with renal failure listed for pancreas transplantation are at a significant risk of mortality even without surgery. Transplantation offers considerable survival benefits, despite associated surgical and immunosuppressive risks. In selected patients, pancreas transplantation remains the benchmark treatment for type 1 diabetes mellitus. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 14, 2013 Category: Urology & Nephrology Authors: van Dellen, D., Worthington, J., Mitu-Pretorian, O. M., Ghazanfar, A., Forgacs, B., Pararajasingam, R., Campbell, B., Parrott, N. R., Augustine, T., Tavakoli, A. Tags: Renal Transplantation Source Type: research

Lower respiratory tract viral infections in pediatric abdominal organ transplant recipients: A single hospital inpatient cohort study
This study indicates that rhinovirus is a significant cause of morbidity in this single center cohort of pediatric abdominal organ transplant recipients. (Source: Pediatric Transplantation)
Source: Pediatric Transplantation - May 14, 2013 Category: Transplant Surgery Authors: Thy T. Tran, Ivan A. Gonzalez, Akin Tekin, Gwenn E. McLaughlin Tags: Original Article Source Type: research

The interplay of donor‐specific antibodies, allograft C4d deposition, and antibody‐mediated rejection
(Source: Pediatric Transplantation)
Source: Pediatric Transplantation - May 14, 2013 Category: Transplant Surgery Authors: Urs Naber, Brian Feingold Tags: Editorial Source Type: research

Lung Deposition and Pharmacokinetics of Nebulized Cyclosporine in Lung Transplant Patients
Journal of Aerosol Medicine and Pulmonary Drug Delivery , Vol. 0, No. 0. (Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery)
Source: Journal of Aerosol Medicine and Pulmonary Drug Delivery - May 13, 2013 Category: Respiratory Medicine Tags: article Source Type: research

Racial Differences in Determinants of Live Donor Kidney Transplantation in the United States
Abstract Few studies have compared determinants of live donor kidney transplantation (LDKT) across all major US racial‐ethnic groups. We compared determinants of racial‐ethnic differences in LDKT among 208 736 patients who initiated treatment for end‐stage kidney disease during 2005–2008. We performed proportional hazards and bootstrap analyses to estimate differences in LDKT attributable to sociodemographic and clinical factors. Mean LDKT rates were lowest among blacks (1.19 per 100 person‐years [95% CI: 1.12–1.26]), American Indians/Alaska Natives‐AI/ANs (1.40 [1.06–1.84]) and Pacific Islanders (1.10 [0...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: T. S. Purnell, P. Xu, N. Leca, Y. N. Hall Tags: Original Article Source Type: research

Efficacy of Sotrastaurin Plus Tacrolimus After De Novo Kidney Transplantation: Randomized, Phase II Trial Results
Abstract Sotrastaurin, a novel immunosuppressant, blocks early T cell activation through protein kinase C inhibition. Efficacy and safety of sotrastaurin with tacrolimus were assessed in a dose‐ranging non‐inferiority study in renal transplant recipients. A total of 298 patients were randomized 1:1:1:1 to receive sotrastaurin 100 (n = 77; discontinued in December 2011) or 200 mg (n = 73) b.i.d. plus standard tacrolimus (sTAC; 5–12 ng/mL), sotrastaurin 300 mg (n = 75) b.i.d. plus reduced tacrolimus (rTAC; 2–5 ng/mL) or enteric‐coated mycophenolic acid (MPA) plus sTAC (n = 73); all patients ...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: G. R. Russ, H. Tedesco‐Silva, D. R. Kuypers, S. Cohney, R. M. Langer, O. Witzke, J. Eris, C. Sommerer, B. von Zur‐Mühlen, E. S. Woodle, J. Gill, J. Ng, J. Klupp, L. Chodoff, K. Budde Tags: Original Article Source Type: research

Predicting End‐Stage Renal Disease After Liver Transplant
Abstract Few equations have been developed to predict end‐stage renal disease (ESRD) after deceased donor liver transplant. This retrospective observational cohort study analyzed all adult deceased donor liver transplant recipients in the Scientific Registry of Transplant Recipients (SRTR) database, 1995–2010. The prediction equation for ESRD was developed using candidate predictor variables available in SRTR after implementation of the allocation policy based on the model for end‐stage liver disease. ESRD was defined as initiation of maintenance dialysis therapy, kidney transplant or registration on the kidney trans...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: A. K. Israni, H. Xiong, J. Liu, N. Salkowski, J. F. Trotter, J. J. Snyder, B. L. Kasiske Tags: Original Article Source Type: research

Enhanced Preservation of Pig Cardiac Allografts by Combining Erythropoietin With Glyceryl Trinitrate and Zoniporide
In conclusion, supplementation of EBPS with erythropoietin, glyceryl trinitrate and zoniporide provided superior donor heart preservation than all other strategies tested. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: A. J. Watson, L. Gao, L. Sun, J. Tsun, A. Doyle, S. C. Faddy, A. Jabbour, Y. Orr, K. Dhital, M. Hicks, P. C. Jansz, P. S. Macdonald Tags: Original Article Source Type: research

Multicenter Australian Trial of Islet Transplantation: Improving Accessibility and Outcomes
Abstract Whilst initial rates of insulin independence following islet transplantation are encouraging, long‐term function using the Edmonton Protocol remains a concern. The aim of this single‐arm, multicenter study was to evaluate an immunosuppressive protocol of initial antithymocyte globulin (ATG), tacrolimus and mycophenolate mofetil (MMF) followed by switching to sirolimus and MMF. Islets were cultured for 24 h prior to transplantation. The primary end‐point was an HbA1c of <7% and cessation of severe hypoglycemia. Seventeen recipients were followed for ≥12 months. Nine islet preparations were transported ...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: P. J. O'Connell, D. J. Holmes‐Walker, D. Goodman, W. J. Hawthorne, T. Loudovaris, J. E. Gunton, H. E. Thomas, S. T. Grey, C. J. Drogemuller, G. M. Ward, D. J. Torpy, P. T. Coates, T. W. Kay, Tags: Original Article Source Type: research

Successful Heart Transplantation From a Donor With Ullrich Congenital Muscular Dystrophy
We report on the successful transplantation and 5‐year follow‐up of a heart from a donor with Ullrich congenital muscular dystrophy (UCMD). The candidate was critically ill at the time of the transplant and the donor organ was declined repeatedly on the match run list due to concerns about organ quality, despite having normal cardiac function by echocardiography on minimal inotropic support. We believe the diagnosis of “muscular dystrophy” in the donor combined with a lack of understanding about the specifics of the diagnosis of UCMD enabled our candidate to receive a primary offer for this organ. We are unaware of...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: C. Plonka, P. D. Wearden, V. O. Morell, S. A. Miller, S. A. Webber, B. Feingold Tags: Case Report Source Type: research

Normothermic Acellular Ex Vivo Liver Perfusion Reduces Liver and Bile Duct Injury of Pig Livers Retrieved After Cardiac Death
Abstract We compared cold static with acellular normothermic ex vivo liver perfusion (NEVLP) as a novel preservation technique in a pig model of DCD liver injury. DCD livers (60 min warm ischemia) were cold stored for 4 h, or treated with 4 h cold storage plus 8 h NEVLP. First, the livers were reperfused with diluted blood as a model of transplantation. Liver injury was determined by ALT, oxygen extraction, histology, bile content analysis and hepatic artery (HA) angiography. Second, AST levels and bile production were assessed after DCD liver transplantation. Cold stored versus NEVLP grafts had higher ALT levels (...
Source: American Journal of Transplantation - May 13, 2013 Category: Transplant Surgery Authors: M. U. Boehnert, J. C. Yeung, F. Bazerbachi, J. M. Knaak, N. Selzner, I. D. McGilvray, O. D. Rotstein, O. A. Adeyi, S. M. Kandel, P. Rogalla, P. M. Yip, G. A. Levy, S. Keshavjee, D. R. Grant, M. Selzner Tags: Original Article Source Type: research

Multifocal periostitis as a complication of chronic use of voriconazole in a lung transplant recipient
Abstract Fungal infections are common in solid organ transplantation. An increasing number of transplant recipients receive antifungal therapy for prolonged duration owing to invasive fungal infections. Herein, we describe a diagnosis of periostitis as a complication of chronic use of voriconazole in a lung transplant recipient. The patient was diagnosed with probable pulmonary aspergillosis and was treated with oral voriconazole for a total of 9 months. Evidence of multifocal periostitis was observed in the axial and appendicular skeleton. Early recognition of this phenomenon is important to prevent unnecessary tests and...
Source: Transplant Infectious Disease - May 13, 2013 Category: Transplant Surgery Authors: R. Tedja, A. El‐Sherief, T. Olbrych, S. Gordon Tags: Images in transplant infectious disease Source Type: research

Living Donor vs. Deceased Donor Liver Transplantation: A Surgeon‐Matched Comparison of Recipient Morbidity and Outcomes
In conclusion, DDLT and LDLT have different complication profiles, but comparable hospital stays and survival rates. In areas of deceased donor organ shortages, LDLT offers an excellent alternative to DDLT because it facilitates access to a liver transplant without compromising short or medium‐term recipient outcomes. This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 11, 2013 Category: Transplant Surgery Authors: Trevor W. Reichman, Helena Katchman, Tomohiro Tanaka, Paul D. Greig, Ian D. McGilvray, Mark S. Cattral, Eberhard L. Renner, Markus Selzner, Anand Ghanekar, Gary Levy, David R. Grant Tags: Original Article Source Type: research

Poor reporting of Randomised Controlled Trials in solid organ transplantation is indicative of a wider problem in surgery
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 11, 2013 Category: Transplant Surgery Authors: Alexander J. Fowler, Riaz A. Agha Tags: Letter to the Editor Source Type: research

Disparities In Kidney Transplants For African-Americans
While the percentage of kidney transplants involving live donors has remained stable for other minority populations, African Americans have seen a decline in live donors even as more of them receive kidney transplants, according to a study by Henry Ford Hospital in Detroit. Those findings were presented at the annual meeting of the American Urological Association in San Diego. "African American race has been associated with disparities in care at every step of the kidney transplant process," says Jesse D. Sammon, D.O... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Successful Corneal Transplant With Pre-Loaded Donor Tissue: A First For Massachusetts Eye And Ear
The first successful cornea transplant with donor endothelial tissue preloaded by an eye bank has been performed at Massachusetts Eye and Ear in Boston, Mass. Roberto Pineda II, M.D., Director of the Refractive Surgery Service at Mass. Eye and Ear, and an Associate Professor of Ophthalmology at Harvard Medical School, recently performed the groundbreaking transplant. Dr. Pineda performed the surgery utilizing donor endothelial tissue that was prepared and pre-loaded into EndoGlide™ (Angiotech Pharmaceuticals, Inc... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Eye Health / Blindness Source Type: news

Transplantation - clinical
Conclusions: The K/DIGO guidelines recommend the use of the eGFRcreat-cys to improve the detection of CKD in patients whom eGFRcreat 45-59mL/min/1.73m². In the present study, we show that this recommendation cannot be extended to transplant recipients. The same conclusion was reached when patients with proteinuria were excluded from the analysis. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Masson, I., Maillard, N., Alamartine, E., Mariat, C., Delanaye, P., Catalano, C., Lemy, A., Lionet, A., Hiesse, C., De Meyer, M., Kianda, M., Toungounz, M., Wissing, M., Racape, J., Abramowicz, D., Jeong, J. H., Yoon, C. S., Kong, J. M., Choi, W. Y., Whan Tags: Abstracts Source Type: research

Renal physiology and kidney stones
Conclusions: The occurrence of a kidney stone is associated with an increased risk of cardiovascular events including AMI, death due to CHD,PTCA/CABG and stroke. These data suggest that people with a clinically recognized kidney stone should be followed more closely to evaluate for the possibility of subsequent cardiovascular events -- younger people and women. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Alexander, R. T., Samuel, S., Wiebe, N., Bello, A., Klarenbach, S., Curhan, G. C., Tonelli, M., Hemmelgarn, B., Mingione, A., Terranegra, A., Aloia, A., Arcidiacono, T., Brasacchio, C., Hou, J., Dell'Antonio, G., Vezzoli, G., Soldati, L., Shimizu, T., Has Tags: Abstracts Source Type: research

Antibody mediated graft damage
Conclusions: In conclusion, protocol biopsy is useful to diagnosis ABMR as early as in the first week pos-Tx. Early recognition of ABMR allows earlier treatment and possibly better long-term graft function in sensitized patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Souza, P. S., Machado, D., Aguirre, A. R., David, D., Barbosa, E., de Paula, F. J., Nahas, W., David-Neto, E., Castro, M. C. R., Pontrelli, P., Rascio, F., Accetturo, M., Castellano, G., Gigante, M., Fiorentino, M., Zito, A., Zaza, G., Stallone, G., Gesua Tags: Abstracts Source Type: research

New perspectives in transplantation therapy
Conclusions: These findings suggest that markers of inflammatory cells, of endothelial damage and of cell regeneration can be detected in the urinary exosomes of transplanted patients. Their levels are correlated with the pathophysiological condition of the graft function and its cellular/molecular causes. These data suggest an interesting diagnostic role for the urinary exosomes. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Dimuccio, V., Ranghino, A., Basso, E., Biancone, L., Camussi, G., Bussolati, B., Grabner, A., Kentrup, D., Muehlmeister, M., Pawelski, H., Pavenstadt, H., Schlatter, E., Tiemann, K., Reuter, S. Tags: Abstracts Source Type: research

Transplantation: basic science
Conclusions:MSC-derived EVs may have a protective role in TCMR by inhibition of T cell proliferation, by differentiation toward a T regulatory phenotype and by reduction of apoptosis and preservation of functional integrity of tubular cells. These protective effects are mediated by the horizontal transfer of specific RNAs from EVs to target cells. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Cantaluppi, V., De Lena, M., Beltramo, S., Ferrario, S., Dellepiane, S., Figliolini, F., Bruno, S., Biancone, L., Segoloni, G. P., Tetta, C., Camussi, G., Prasad, N., Jaisawal, A., Yadav, B., Agarwal, V., Tripathi, D., Nunez-Lozano, R., Quiros, Y., Sanche Tags: Abstracts Source Type: research

Transplantation: clinical studies - A
Conclusions:Vitamin D deficiency is one of the causes of endothelial dysfunction in renal transplant recipients. Further studies are needed to clarify whether FGF-23 is a marker or a potential initiation for endothelial dysfunction and the effect of vitamin D replacement on endothelial functions in these patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - May 10, 2013 Category: Urology & Nephrology Authors: Yildirim, T., Yilmaz, R., Altindal, M., Turkmen, E., Arici, M., Altun, B., Erdem, Y., Guliyev, O., Erkmen Uyar, M., Tutal, E., Bal, Z., Sezer, S., Erkmen Uyar, M., Bal, U., Bal, Z., Tutal, E., Say{iota}n, B., Guliyev, O., Erdemir, B., Sezer, S., O'Rourke- Tags: Abstracts Source Type: research

Well: Pressing Patients to Change Their Minds
When my patient took herself off the active liver transplant list, I had to ask myself a question: Did I have some type of duty to get her to change her mind? (Source: NYT Health)
Source: NYT Health - May 9, 2013 Category: Consumer Health News Authors: By BARRON H. LERNER, M.D. Tags: Doctors Ethics (Institutional) Pentecostal Churches Featured religion Source Type: news

Renal Function and Cardiovascular Outcomes after Living Donor Nephrectomy in the United Kingdom: Quality and Safety Revisited
ConclusionIn this study we demonstrate that mild renal dysfunction is common following LDN, however due to the short duration of follow up we are unable to comment on whether this subsequently leads to an increased risk of developing of cardio‐vascular disease. (Source: BJU International)
Source: BJU International - May 9, 2013 Category: Urology & Nephrology Authors: Nilay Patel, Phil Mason, Sally Rushton, Alex Hudson, Rutger Ploeg, Peter Friend, Sanjay Sinha, Mark Sullivan Tags: Upper Urinary Tract Source Type: research

How Should Hepatitis E Virus Infection Be Defined in Organ‐Transplant Recipients?
(Source: American Journal of Transplantation)
Source: American Journal of Transplantation - May 9, 2013 Category: Transplant Surgery Authors: N. Kamar, L. Rostaing, F. Legrand‐Abravanel, J. Izopet Tags: Letter to the Editor Source Type: research

Sotrastaurin in Calcineurin Inhibitor–Free Regimen Using Everolimus in De Novo Kidney Transplant Recipients
Abstract Sotrastaurin, a novel selective protein‐kinase‐C inhibitor, inhibits early T cell activation via a calcineurin‐independent pathway. Efficacy and safety of sotrastaurin in a calcineurin inhibitor—free regimen were evaluated in this two‐stage Phase II study of de novo kidney transplant recipients. Stage 1 randomized 131 patients (2:1) to sotrastaurin 300 mg or cyclosporine A (CsA). Stage 2 randomized 180 patients (1:1:1) to sotrastaurin 300 or 200 mg or CsA. All patients received basiliximab, everolimus (EVR) and prednisone. Primary endpoint was composite efficacy failure rate of treated biopsy‐prove...
Source: American Journal of Transplantation - May 9, 2013 Category: Transplant Surgery Authors: H. Tedesco‐Silva, M. M. L. Kho, A. Hartmann, S. Vitko, G. Russ, L. Rostaing, K. Budde, J. M. Campistol, J. Eris, I. Krishnan, U. Gopalakrishnan, J. Klupp Tags: Original Article Source Type: research