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This page shows you the most recent publications within this specialty of the MedWorm directory.

Optimising utilisation of kidneys from deceased donors over 60 years: Five–year outcomes after implementation of a combined clinical and histological allocation algorithm
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 22, 2013 Category: Transplant Surgery Authors: E S Pierobon, S Sandrini, N Fazio, G Rossini, I Fontana, I Boschiero, M Gropuzzo, E Gotti, D Donati, E Minetti, M T Gandolfo, A Brunello, C Libetta, A Secchi, S Chiaramonte, P Rigotti Tags: Original Article Source Type: research

Coronary Vasospasm Attributable to Fibromuscular Dysplasia: The Long Bridge to Transplant [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 21, 2013 Category: Cardiology Authors: Castellano, J. M., Vaishnava, P., Castillo, J. G., Anyanwu, A. C., Fuster, V. Tags: Other heart failure, Other Vascular biology Images and Case Reports in Heart Failure Source Type: research

Temporal Trends in Treatment and Outcomes for Advanced Heart Failure With Reduced Ejection Fraction From 1993-2010: Findings From a University Referral Center [Original Articles]
Conclusions— Over the past 2 decades, patients with advanced HF referred to and managed at a tertiary university referral center have benefited from advances in HF medications and devices, as evidenced by improvements in overall survival and sudden death risk. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 21, 2013 Category: Cardiology Authors: Loh, J. C., Creaser, J., Rourke, D. A., Livingston, N., Harrison, T. K., Vandenbogaart, E., Moriguchi, J., Hamilton, M. A., Tseng, C.-H., Fonarow, G. C., Horwich, T. B. Tags: Health policy and outcome research, Congestive Original Articles Source Type: research

Pulsatility and the Risk of Nonsurgical Bleeding in Patients Supported With the Continuous-Flow Left Ventricular Assist Device HeartMate II [Original Articles]
Conclusions— Reduced pulsatility in patients supported with the continuous-flow LVAD HeartMate II is associated with an increased risk of nonsurgical bleeding, as evaluated by PI. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - May 21, 2013 Category: Cardiology Authors: Wever-Pinzon, O., Selzman, C. H., Drakos, S. G., Saidi, A., Stoddard, G. J., Gilbert, E. M., Labedi, M., Reid, B. B., Davis, E. S., Kfoury, A. G., Li, D. Y., Stehlik, J., Bader, F. Tags: Congestive, CV surgery: transplantation, ventricular assistance, cardiomyopathy Original Articles Source Type: research

Recurrent upper gastrointestinal bleeding masquerading as gastric variceal bleeding on endoscopy after liver transplantation
Abstract Splenic artery ligation is commonly performed today, especially during live donor liver transplantation to prevent portal hyper‐perfusion and small‐for‐size syndrome. The current case describes submucosal gastric arterial lesions that developed following splenic artery ligation during live donor liver transplantation. Those arterial lesions manifested with massive gastrointestinal bleeding four years following liver transplant and they had an endoscopic appearance similar to that of gastric varices. Cyanoacrylate, the therapeutic modality of choice for gastric varices, is associated with a significant risk o...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Ibrahim A. Hanouneh, Bradley D. Confer, Nizar N. Zein, Naim Alkhouri, Bijan Eghtesad Tags: Images in Liver Transplantation Source Type: research

Acute on chronic liver failure: Excellent outcome after liver transplantation but high mortality on the wait list
In conclusion, this study shows that LT remains the only therapeutic option in the vast majority of patients with ACLF. However, LT was feasible in only a quarter of patients with a 5‐year survival rate of more than 80%. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Armin Finkenstedt, Karin Nachbaur, Heinz Zoller, Michael Joannidis, Johann Pratschke, Ivo W. Graziadei, Wolfgang Vogel Tags: Original Article Source Type: research

Intra‐operative hypercoagulability during liver transplantation as demonstrated by thromboelastography
Abstract Thrombotic complications are more common in liver disease than might be expected given the coagulopathy described by conventional coagulation tests. Some of these complications may be life‐threatening. The phenomenon of hypercoagulation is associated with complications in many populations, but the incidence in liver transplant recipients is unclear. A retrospective database review of intra‐operative thromboelastography (TEG) for 124 liver transplant recipients. We assessed the prevalence of hypercoagulation in this group, and investigated the relative frequency of both shortened TEG r‐time and increased G va...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Dominik Krzanicki, Anita Sugavanam, Susan Mallett Tags: Original Article Source Type: research

Expedited liver allocation in the U.S.: A critical analysis
Conclusions: Transplantation of livers allocated by means of an expedited refusal code is asymmetric across regions and in some instances results in bypass of patients with higher waitlist priority but without notification of the bypassed center. Short‐term graft function after EP allocation was excellent. Policies governing EP allocation should be created in order to improve access to available organs. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Milan Kinkhabwala, Joel Lindower, John F Reinus, Anita L Principe, Paul J Gaglio Tags: Challenges and Controversies in LT Source Type: research

Deceased donor liver transplantation in infants and small children: Are partial grafts riskier than whole organs?
Conclusions: Deceased‐donor partial liver transplantation has become less risky over time, and now has comparable outcomes to whole liver transplantation in infants and young children. This study supports the use of partial DD liver grafts in young children in an attempt to significantly increase the pediatric organ pool. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Ryan P. Cauley, Khashayar Vakili, Kristina Potanos, Nora Fullington, Dionne A. Graham, Jonathan A. Finkelstein, Heung Bae Kim Tags: Original Article Source Type: research

Selection and outcome of living donors with a remnant volume less than 30% after right hepatectomy
Abstract Insufficient is the evidence defining the safe minimal remnant volume after living donor hepatectomy. The aim of this study was to evaluate the outcomes of living donors with a remnant‐to‐total volume ratio (RTVR) less than 30% after right hepatectomy by the selection criteria: preservation of middle hepatic vein (MHV), age<50 years, and no or mild fatty change in healthy adults. All living donors who underwent right hepatectomy saving MHV at the authors' institution between January 2005 and September 2011 were divided into 2 groups: group A with an RTVR < 30% and group B with an RTVR ≥ 30%. Perioperat...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Seong Hoon Kim, Young Kyu Kim, Seung Duk Lee, Sang‐Jae Park Tags: Original Article Source Type: research

Randomized multicenter trial comparing tacrolimus plus mycophenolate mofetil with tacrolimus plus steroids among HCV‐positive recipients of living donor liver transplantation
In conclusion, our steroid‐avoidance regimen had no apparent impact on LDLT outcomes for HCV‐positive recipients. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Yasutsugu Takada, Toshimi Kaido, Katsuhiro Asonuma, Hiroyuki Sakurai, Shoji Kubo, Tetsuya Kiuchi, Yukihiro Inomata, Shuji Isaji, Hayami Tsumura, Satoshi Teramukai, Yoshihiro Matsubara, Satomi Sakabayashi, Shinji Uemoto Tags: Original Article Source Type: research

Chronic lithium treatment protects against liver ischemia‐reperfusion injury in rats
In this study, we aimed to evaluate the effects of lithium in a model of liver ischemia/reperfusion injury (I/R) in rats. Chronic treatment with lithium (2 mmol/kg, for 3 days before ischemia) decreased I/R injury, whereas acute treatment with a single dose of lithium (2 mmol/kg, 1 h before ischemia) did not confer any protection in partial hepatic I/R model. Furthermore, chronic lithium‐treated rats had a significantly better survival rate (60%) as compared to saline (27%) in total hepatic I/R survival model. Chronic lithium treatment protected against liver I/R injury, as indicated by lower serum aminotransferase level...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Anding Liu, Haoshu Fang, Uta Dahmen, Olaf Dirsch Tags: Original Article Source Type: research

Multicenter experience using telaprevir or boceprevir with peginterferon and ribavirin to treat hepatitis C genotype 1 after liver transplantation
In conclusion, TVR or BOC combined with Peg‐IFN/RBV achieved on‐treatment virological response rates of approximately 50‐60% in patients with recurrent HCV after LT but significant side‐effects were common. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Surakit Pungpapong, Bashar A. Aqel, Ludi Koning, Jennifer L. Murphy, Tanisha M. Henry, Kristen L. Ryland, Maria L. Yataco, Raj Satyanarayana, Barry G. Rosser, Hugo E. Vargas, Michael R. Charlton, Andrew P. Keaveny Tags: Original Article Source Type: research

To The Editors
(Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Andrea DiMartini, Mary Amanda Dew Tags: Letter to the Editor Source Type: research

Fairly rare spontaneous disappearance of hepatic artery aneurysm following living donor liver transplantation
(Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Takeo Toshima, Mitsuo Shimada, Toru Ikegami, Toru Utsunomiya, Tetsuya Ikemoto, Yuji Morine, Tomoharu Yoshizumi, Yuji Soejima, Ken Shirabe, Yoshihiko Maehara Tags: Letter from the Frontline Source Type: research

Early use of renal‐sparing agents in liver transplantation: A closer look
Abstract Renal dysfunction is a critical issue for liver transplant candidates and recipients. Acute and chronic nephrotoxicity, however, are the compromise for the potent immunosuppression provided by calcineurin inhibitors (CNIs). To maintain graft and patient survival afforded by CNIs while minimizing renal dysfunction in liver transplant patients, the reduction, delay, or elimination of CNIs in immunosuppression regimens is being implemented more frequently by clinicians. The void left by standard‐dose CNIs is being filled by nonnephrotoxic immunosuppressants such as the mycophenolates and mammalian target of rapamyc...
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: James F. Trotter, Monica Grafals, Angel E. Alsina Tags: Review Article Source Type: research

Respiratory risk score for the prediction of 3‐month mortality and prolonged ventilation after liver transplantation
Conclusions: This study provides the first prognostic model for the prediction of 3‐month mortality and prolonged ventilation after liver transplantation with high sensitivity, specificity, and good model accuracy. Application of the RRS on an external cohort would be desirable for its further validation and introduction as a clinical tool for intensive care resource planning and prognostic decision making. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: M. Kleine, F. W. R. Vondran, K. Johanning, K. Timrott, H. Bektas, F. Lehner, J. Klempnauer, H. Schrem Tags: Original Article Source Type: research

Efficacy of liver graft washout as a function of perfusate, pressure, and temperature
ConclusionNo difference in portal washout efficacy between colloidal solutions, HTK, and RL were found. Simultaneous arterial and portal washout using RL at 37 °C and 100 mmHg pressure resulted in the lowest RBC retention and shortest washout time. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Ivo C.J.H. Post, Marcel C. Dirkes, Michal Heger, Joanne Verheij, Kora M. de Bruin, Dirk de Korte, Roelof J. Bennink, Thomas M. van Gulik Tags: Original Article Source Type: research

Quiz Page JUNE 2013: Graft Dysfunction After Kidney Transplantation in an Adolescent
A 15-year-old boy with no relevant medical or family history presented with nausea and fatigue. His blood pressure was 150/90 mm Hg, but the rest of the physical examination findings were normal. Laboratory investigations showed the following values: serum creatinine, 18.9 mg/dL (estimated glomerular filtration rate [GFR], 5 mL/min/1.73 m2 by the modified Schwartz formula); serum urea nitrogen, 549 mg/dL; parathyroid hormone, 496 (reference range, 9-55) pg/mL; and hemoglobin, 9.0 g/dL. Urinalysis showed hematuria (1+) and proteinuria (protein excretion, 930 mg/24 h), with occasional red blood cells on sediment evaluation. ...
Source: American Journal of Kidney Diseases - May 20, 2013 Category: Urology & Nephrology Authors: Badria Al Ghaithi, Siew-Le Chong, Reham Al Mardini, Seetha Radhakrishnan, Rohan John, Lisa A. Robinson Source Type: research

Donor risk index for african american liver transplant recipients with hepatitis C virus
Abstract African‐American (AA) liver transplant (LT) recipients with hepatitis C virus (HCV) have higher rates of graft loss than other racial/ethnic groups. The Donor Risk Index (DRI) predicts graft loss but is neither race nor disease‐specific and may not be optimal for assessing donor risk for AA HCV‐positive LT recipients. We developed a DRI for AA with HCV with the goal of enhancing graft loss predictions. All U.S. HCV‐positive adult AA first deceased donor LTs surviving ≥30 days from 3/2002 to 12/2009 were included. A total of 1766 AA LT recipients were followed for median 2.8 (IQR 1.3‐4.9) years. Indepen...
Source: Hepatology - May 20, 2013 Category: Internal Medicine Authors: Nathan J Shores, Jennifer L. Dodge, Sandy Feng, Norah A. Terrault Tags: Viral Hepatitis Source Type: research

Markers of operational immune tolerance after pediatric liver transplantation in patients under immunosuppression
Abstract A prospective identification of the estimated 20–50% of pediatric LTX recipients developing operational tolerance would be of great clinical advantage. So far markers of immune tolerance – T‐cell subpopulations or gene expression profiles – have been investigated only retrospectively in successfully weaned patients. Fifty children aged 8–265 months (median 89) were investigated 1–180 months (median 44) after LTX under ongoing immunosuppression. T‐cell subpopulations were measured during regular post‐transplant visits using FACS (Vδ1‐ vs. Vδ2‐γδ‐T cells and Tregs). A Vδ1/Vδ2‐γδ‐T...
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: S. Schulz‐Juergensen, L. Marischen, D. Wesch, H. H. Oberg, F. Fändrich, D. Kabelitz, M. Burdelski Tags: Original Article Source Type: research

Re‐evaluation of the indications for liver transplantation in Wilson's disease based on the outcomes of patients referred to a transplant center
Abstract The aim of this study was to re‐evaluate the indications and timing of LT for WD. From 2000 to 2009, eight patients with WD who had been referred to our institution for LT were enrolled in this study. The mean patient age was 15.9 yr (range, 7–37 yr). Four patients could not receive LT, because there were no available donors. All four patients were treated with chelating agent medication. Three of them (two of two patients with fulminant WD and one of two with cirrhotic WD) who did not undergo LT are still alive and doing well with stable liver functional tests. Only one of the patients with cirrhotic WD who...
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Yuki Ohya, Hideaki Okajima, Masaki Honda, Shintaro Hayashida, Hiroko Suda, Shiro Matsumoto, Kwang‐Jong Lee, Hidekazu Yamamoto, Takayuki Takeichi, Hiroshi Mitsubuchi, Katsuhiro Asonuma, Fumio Endo, Yukihiro Inomata Tags: Original Article Source Type: research

Hematopoietic stem cell transplantation for children with primary immunodeficiency diseases: Single center experience in Jordan
Abstract HSCT can be curative for many PID. Little is known about the outcome of HSCT for patients with PID in the developing countries. We retrospectively reviewed all children with PID who received HSCT at KHCC in Jordan between August 2003 and October 2011. Twenty‐eight patients were identified. The median age was 16 months (3 months–17 yr). Patients' diagnoses were SCID (n = 16), CHS (n = 3), HLH (n = 3), WAS (n = 2), Griscelli syndrome (n = 1), ALPS (n = 1), Omenn's syndrome (n = 1), and DiGeorge syndrome (n = 1). Seventeen patients received HLA‐matched related HSCT, eight received maternal un...
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Nisreen Amayiri, Abdulhadi Al‐Zaben, Lubna Ghatasheh, Haydar Frangoul, Ayad Ahmed Hussein Tags: Original Article Source Type: research

Immunogenicity of pandemic influenza A H1N1/2009 adjuvanted vaccine in pediatric solid organ transplant recipients
Abstract The aim of this study was to assess the immunogenicity of a vaccine against this virus in a prospective cohort of transplanted pediatric patients without previous influenza infection who received one dose of MF59®‐adjuvanted pandemic H1N1/2009 vaccine. Seventeen patients who were being regularly followed up at the Outpatient Clinic of the Children's Transplant Unit (liver and kidney transplantation) in Hospital Universitari Vall d′Hebron (Barcelona) were included. Seroconversion was demonstrated in 15 of 17 (88.2%) vaccinated children. There were no rejection episodes or major adverse events. The MF59®‐adj...
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: J. Gavaldà, E. Cabral, P. Perez‐Romero, O. Len, T. Aydillo, M. Campins, J. Quintero, M. Peghin, J. Nieto, R. Charco, A. Pahissa, E. Cordero, Tags: Original Article Source Type: research

131I‐Metaiodobenzylguanidine conditioning regimen in children with neuroblastoma undergoing stem cell transplantation
(Source: Pediatric Transplantation)
Source: Pediatric Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Erman Atas, Vural Kesik, Erol Kismet, Vedat Koseoglu Tags: Letter to the Editor Source Type: research

Immune function assay (ImmuKnow) as a predictor of allograft rejection and infection in kidney transplantation
ConclusionsThe IK assay combined with other biomarkers can be used to identify kidney transplant patients at high risk of rejection and infection. (Source: Clinical Transplantation)
Source: Clinical Transplantation - May 20, 2013 Category: Transplant Surgery Authors: Jun He, Yang Li, Hui Zhang, Xudong Wei, Hao Zheng, Chao Xu, Xiaojing Bao, Xiaoni Yuan, Jianquan Hou Tags: Original Article Source Type: research

Reasons for dose reduction of mycophenolate mofetil during the first year after renal transplantation and its impact on graft outcome
ConclusionsIn this retrospective cohort, by far the most important reason for MMF dose reduction during the first post‐transplantation year was hematological. MMF dose reductions ≥50% increased the risk of acute rejection but did not compromise graft survival.This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: Thomas Vanhove, Dirk Kuypers, Kathleen J. Claes, Pieter Evenepoel, Björn Meijers, Maarten Naesens, Yves Vanrenterghem, Tom Cornelis, Bert Bammens Tags: Original Article Source Type: research

Msc and kidney transplantation: Pre‐transplant infusion protects from graft dysfunction While fostering immunoregulation
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: Norberto Perico, Federica Casiraghi, Eliana Gotti, Martino Introna, Marta Todeschini, Regiane Aparecida Cavinato, Chiara Capelli, Alessandro Rambaldi, Paola Cassis, Paola Rizzo, Monica Cortinovis, Marina Noris, Giuseppe Remuzzi Tags: Original Article Source Type: research

Alterations of naïve and memory B cell subsets are associated with risk of rejection and infection in heart recipients
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: N Lanio, E Sarmiento, A Gallego, L Calahorra, M Jaramillo, J Navarro, J Palomo, J Fernandez‐Yañez, M Ruiz, E Fernandez‐Cruz, J Carbone Tags: Original Article Source Type: research

Clinical and microbial impact of screening kidney allograft preservative solution for bacterial contamination with high sensitivity methods
In conclusion, the use of more sensitive culture methods increases the rate of bacterial contamination of PS and is associated with an increased prescription of antibiotics and increased ESBL‐PE carriage and related infections. Therefore, the systematic use of PS blood bottle cultures in kidney transplantation may have no benefit and might increase the rate of ESBL‐PE emergence. This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: Dominique Bertrand, Nicolas Pallet, Albane Sartorius, Jean Ralph Zahar, Rebecca Sberro Soussan, Olivier Lortholary, Christophe Legendre, Marie‐France Mamzer Tags: Original Article Source Type: research

Systematic Review of Mouse Kidney Transplantation
This article is protected by copyright. All rights reserved. (Source: Transplant International)
Source: Transplant International - May 20, 2013 Category: Transplant Surgery Authors: George Hondag Tse, Jeremy Hughes, Lorna Palmer Marson Tags: Review Article Source Type: research

The best way to prevent cytomegalovirus infection after liver transplantation: the debate goes on
(Source: Transplant International)
Source: Transplant International - May 19, 2013 Category: Transplant Surgery Authors: Herold J. Metselaar, Margo J. H. Campenhout, Annemiek A. Eijk Tags: Invited commentary Source Type: research

The effect of rabbit antithymocyte globulin on human mesenchymal stem cells
Summary Mesenchymal stem cells (MSCs) possess immunomodulatory properties which are of key interest for their application in autoimmunity and transplantation. In transplantation, administration of MSCs has shown promising results in preclinical models and has recently moved to clinical trials. Therefore, it is important to study the interactions between MSCs and immunosuppressive drugs currently used in transplantation. We aimed to analyze the effect of rabbit antithymocyte globulin (rATG) MSCs. MSCs were obtained from perirenal fat of kidney donors and exposed to ranging doses of rATG (Thymoglobulin®, Genzyme; 0.5–100�...
Source: Transplant International - May 19, 2013 Category: Transplant Surgery Authors: Marcella Franquesa, Carla C. Baan, Sander S. Korevaar, Anja U. Engela, Marieke Roemeling‐van Rhijn, Willem Weimar, Michiel G. H. Betjes, Josep M. Grinyo, Martin J. Hoogduijn Tags: Original Article Source Type: research