Transplant Surgery This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 28.

Britain's longest surviving heart transplant patient celebrates 30 years with donated organ and meets the surgeon who saved his life
John McCafferty, 70, from Buckinghamshire, has also defied the odds by living an amazing 25 extra years longer than expected.
Source: the Mail online | Health - November 8, 2012 Category: Consumer Health News Source Type: news

Transplant patient marks 30 years
A 70-year-old man is thought to have become the UK's longest surviving heart transplant patient.
Source: BBC News | Health | UK Edition - November 8, 2012 Category: Consumer Health News Source Type: news

VIDEO: Transplant patient marks 30 years
The UK's longest surviving heart transplant patient is celebrating 30 years since his operation.
Source: BBC News | Health | UK Edition - November 8, 2012 Category: Consumer Health News Source Type: news

Antimicrobial activity of nanocomposite zirconium nitride/silver coatings to combat external bone fixation pin infections.
Abstract During external fixation, temporary implants are used to penetrate the skin, muscle and bone to support severely fractured bones. This creates a biologically critical interface at the site of entry, which potentially allows a risk of infection. The aim of this study, therefore, was to investigate potential antimicrobial nanocomposites to combat infection. Magnetron sputtering was used to produce zirconium nitride/silver nanocomposite coatings, which were prepared at two different silver concentrations of 15.5 at.% and 29.8 at.%. These coatings were characterized for morphology, chemical composition, and an...
Source: The International Journal of Artificial Organs - November 8, 2012 Category: Transplant Surgery Authors: Wickens DJ, West G, Kelly PJ, Verran J, Lynch S, Whitehead KA Tags: Int J Artif Organs Source Type: research

Chronic Histological Damage in Early Indication Biopsies Is an Independent Risk Factor for Late Renal Allograft Failure
The impact of early histological lesions of renal allografts on long‐term graft survival remains unclear. We included all renal allograft recipients transplanted at a single center from 1991 to 2001 (N = 1197). All indication biopsies performed within the first year after transplantation were rescored according to the current Banff classification. Mean follow‐up time was 14.8 ± 2.80 years. In multivariate Cox proportional hazards analysis, arteriolar hyalinosis and transplant glomerulopathy were independently associated with death‐censored graft survival, adjusted for baseline demographic covariates. Arteriolar hyal...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: M. Naesens, D. R. J. Kuypers, K. De Vusser, Y. Vanrenterghem, P. Evenepoel, K. Claes, B. Bammens, B. Meijers, E. Lerut Tags: Original Article Source Type: research

Does Expanded Criteria Donor Status Modify the Outcomes of Kidney Transplantation From Donors After Cardiac Death?
In conclusion, ECD status or higher KDRI score did not appreciably increase the relative hazard of adverse graft and patient outcomes in DCD KTR. These findings suggest that the judicious use of ECD/DCD donor kidneys may be an appropriate strategy to expand the donor pool.
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: S. K. Singh, S. J. Kim Tags: Original Article Source Type: research

MicroRNAs as Biomarkers in Solid Organ Transplantation
Important progress has been made in improving short‐term outcomes in solid organ transplantation. However, long‐term outcomes have not improved during the last decades. There is a critical need for biomarkers of donor quality, early diagnosis of graft injury and treatment response. MicroRNAs (miRNAs) are a class of small single‐stranded noncoding RNAs that function through translational repression of specific target mRNAs. MiRNA expression has been associated with different diseases and physiological conditions. Moreover, miRNAs have been detected in different biological fluids and these circulating miRNAs can distin...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: V. R. Mas, C. I. Dumur, M. J. Scian, R. C. Gehrau, D. G. Maluf Tags: Minireview Source Type: research

BK Virus Replication and Nephropathy After Alemtuzumab‐Induced Kidney Transplantation
BK virus nephropathy (BKVN) is a recognized cause of graft failure in kidney transplant recipients. There are limited data on the epidemiology of BK virus (BKV) infection after alemtuzumab induction. By clinical protocol, the kidney transplant recipients at our center were screened with BKV plasma PCR monthly for the first 4 months posttransplant then every 2–3 months for 2 years. A single center retrospective cohort study of all kidney transplant recipients from January 2008 to August 2010 was conducted to determine incidence and outcomes of BKV infection. Descriptive statistics and Kaplan–Meier analysis was performed...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: N. Theodoropoulos, E. Wang, S. Penugonda, D. P. Ladner, V. Stosor, J. Leventhal, J. Friedewald, M. P. Angarone, M. G. Ison Tags: Brief Communication Source Type: research

High Genetic Barrier Nucleos(t)ide Analogue(s) for Prophylaxis From Hepatitis B Virus Recurrence After Liver Transplantation: A Systematic Review
The combination of hepatitis B immunoglobulin (HBIG) and nucleos(t)ide analogues [NA(s)] is considered as the standard of care for prophylaxis against HBV recurrence after liver transplantation (LT), but the optimal protocol is controversial. We evaluated the efficacy of the newer NAs with high genetic barrier (hgbNA) [i.e. entecavir (ETV) or tenofovir (TDF)] with or without HBIG as prophylaxis against HBV recurrence after LT. In total, 519 HBV liver transplant recipients from 17 studies met the inclusion criteria and they were compared to those under lamivudine (LAM) and HBIG who had been selected in our previous review. ...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: E. Cholongitas, G.V. Papatheodoridis Tags: Original Article Source Type: research

Targeting TIM‐1 on CD4 T Cells Depresses Macrophage Activation and Overcomes Ischemia‐Reperfusion Injury in Mouse Orthotopic Liver Transplantation
This study analyzes mechanisms by which TIM‐1 affects liver ischemia‐reperfusion injury (IRI) in a murine model of prolonged cold storage followed by OLT. Livers from C57BL/6 mice, preserved at 4°C in the UW solution for 20 h, were transplanted to syngeneic recipients. There was an early (1 h) increased accumulation of TIM‐1+ activated CD4 T cells in the ischemic OLTs. Disruption of TIM‐1 signaling with a blocking mAb (RMT1–10) ameliorated liver damage, evidenced by reduced sALT levels and well‐preserved architecture. Unlike in controls, TIM‐1 blockade diminished OLT expression of Tbet/IFN‐γ, but amplifie...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: Y. Zhang, H. Ji, X. Shen, J. Cai, F. Gao, K. M. Koenig, C. M. Batikian, R. W. Busuttil, J. W. Kupiec‐Weglinski Tags: Original Article Source Type: research

Cardiac Troponin T Before and After Kidney Transplantation: Determinants and Implications for Posttransplant Survival
Pretransplant cardiac troponin T(cTnTpre) is a significant predictor of survival postkidney transplantation. We assessed correlates of cTnT levels pre‐ and posttransplantation and their relationship with recipient survival. A total of 1206 adult recipients of kidney grafts between 2000 and 2010 were included. Pretransplant cTnT was elevated (≥0.01 ng/mL) in 56.4%. Higher cTnTpre was associated with increased risk of posttransplant death/cardiac events independent of cardiovascular risk factors. Elevated cTnTpre declined rapidly posttransplant and was normal in 75% of recipients at 3 weeks and 88.6% at 1 year. Elevated ...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: M. T. Keddis, Z. M. El‐Zoghby, M. El Ters, E. Rodrigo, P. A. Pellikka, A. S. Jaffe, Fernando G. Cosio Tags: Original Article Source Type: research

Combined Liver Transplantation and Gastric Sleeve Resection for Patients With Medically Complicated Obesity and End‐Stage Liver Disease
Obesity is increasingly common before and after liver transplantation (LT), yet optimal management remains unclear. Our aim was to analyze the effectiveness of a multidisciplinary protocol for obese patients requiring LT, including a noninvasive pretransplant weight loss program, and a combined LT plus sleeve gastrectomy (SG) for obese patients who failed to lose weight prior to LT. Since 2006, all patients referred LT with a BMI > 35 were enrolled. There were 37 patients who achieved weight loss and underwent LT alone, and 7 who underwent LT combined with SG. In those who received LT alone, weight gain to BMI > 35 w...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: J. K. Heimbach, K. D. S. Watt, J. J. Poterucha, N. Francisco Ziller, S. D. Cecco, M. R. Charlton, J. E. Hay, R. H. Wiesner, W. Sanchez, C. B. Rosen, J. M. Swain Tags: Original Article Source Type: research

Safety and Efficacy of Subcutaneous Hepatitis B Immunoglobulin After Liver Transplantation: An Open Single‐Arm Prospective Study
In conclusion, SC HBIG for long‐term prophylaxis of post‐LT HBV reinfection resulted safe, well accepted, and effective in maintaining adequate anti‐HBs levels.
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: G. G. Di Costanzo, A. G. Lanza, F. P. Picciotto, M. Imparato, C. Migliaccio, M. De Luca, V. Scuderi, R. Tortora, G. Cordone, W. Utech, F. Calise Tags: Original Article Source Type: research

Polyomavirus BK Replication in De Novo Kidney Transplant Patients Receiving Tacrolimus or Cyclosporine: A Prospective, Randomized, Multicenter Study
Polyomavirus BK (BKV)‐associated nephropathy causes premature kidney transplant (KT) failure. BKV viruria and viremia are biomarkers of disease progression, but associated risk factors are controversial. A total of 682 KT patients receiving basiliximab, mycophenolic acid (MPA), corticosteroids were randomized 1:1 to cyclosporine (CsA) or tacrolimus (Tac). Risk factors were analyzed in 629 (92.2%) patients having at least 2 BKV measurements until month 12 posttransplant. Univariate analysis associated CsA‐MPA with lower rates of viremia than Tac‐MPA at month 6 (10.6% vs. 16.3%, p = 0.048) and 12 (4.8% vs. 12.1%, p = 0...
Source: American Journal of Transplantation - November 8, 2012 Category: Transplant Surgery Authors: H. H. Hirsch, F. Vincenti, S. Friman, M. Tuncer, F. Citterio, A. Wiecek, E. H. Scheuermann, M. Klinger, G. Russ, M. D. Pescovitz, H. Prestele Tags: Original Article Source Type: research

Natural and modified history of single-ventricle physiology in adult patients [CONGENITAL]
CONCLUSIONS Adult patients with SV are at high risk of reoperations and need of transplant and complications. Nevertheless, in the presence of a moderately reduced peak of VO2 and a moderate reduction in the EF detected at the MRI, the results of the evaluation of daily quality of life are incredibly high.
Source: European Journal of Cardio-Thoracic Surgery - November 8, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Angeli, E., Pace Napoleone, C., Balducci, A., Formigari, R., Lovato, L., Candini, L., Oppido, G., Gargiulo, G. Tags: CONGENITAL Source Type: research

Immunosuppressive properties of a series of novel inhibitors of the monocarboxylate transporter MCT‐1
Summary We have recently described the immunosuppressive properties of AR‐C117977 and AR‐C122982, representatives of a group of compounds identified as inhibitors of lactate transporters (monocarboxylate transporters; MCTs). These compounds demonstrate the potential therapeutic usefulness of inhibiting MCT‐1, but their physical and metabolic properties made them unsuitable for further development. We have therefore tried to find analogues with similar immunosuppressive efficacy and a more suitable profile for oral administration. Five analogues of AR‐C117977 were synthesised and screened for binding to the transpor...
Source: Transplant International - November 8, 2012 Category: Transplant Surgery Authors: Clara Påhlman, Zhongquan Qi, Clare M. Murray, Douglas Ferguson, Robert V. Bundick, David K. Donald, Henrik Ekberg Tags: Original Article Source Type: research

Soluble CD30 correlates with clinical but not subclinical renal allograft rejection
In conclusion, sCD30 correlated with clinical, but not subclinical renal allograft rejection limiting its clinical utility as a noninvasive rejection screening biomarker in patients with stable allograft function receiving tacrolimus–mycophenolate‐based immunosuppression.
Source: Transplant International - November 8, 2012 Category: Transplant Surgery Authors: Patricia Hirt‐Minkowski, Michèle Roth, Gideon Hönger, Patrizia Amico, Helmut Hopfer, Stefan Schaub Tags: Original Article Source Type: research

Adaptive functioning and its correlates after intestine and liver transplantation
Abstract In this cross‐sectional study, we compared levels of adaptive functioning and examined potential correlates of adaptive functioning in 18 pediatric intestine (ITX) and 22 liver (LTX) recipients transplanted between June 2003 and March 2009. Family caregivers completed the ABAS‐II scale and provided socio‐demographic information regarding recipients' age at transplantation, gender, ethnicity, time since transplantation, and caregivers' role, ethnicity, education, and family income. Overall adaptive functioning and all three adaptive functioning subdomain scores were significantly lower in ITX patients compare...
Source: Pediatric Transplantation - November 8, 2012 Category: Transplant Surgery Authors: Diana A. Shellmer, Annette DeVito Dabbs, Mary Amanda Dew, Lauren Terhorst, Robert B. Noll, Beverly Kosmach‐Park, George Mazariegos Tags: Original Article Source Type: research

An apparent case of undiagnosed donor Kawasaki disease manifesting as coronary artery aneurysm in a pediatric heart transplant recipient
We present a case of coronary ectasia and LAD coronary artery aneurysm with angiographic characteristics of Kawasaki disease in a three‐yr‐old girl two‐yr status post‐orthotopic heart transplant. Coronary anomalies were noted during initial screening coronary angiography two yr after transplant. Subsequent review of the donor echocardiogram revealed that the LMCA had been mildly dilated prior to transplant. In the absence of any symptoms consistent with Kawasaki disease in the transplant recipient, this appears to be a case of Kawasaki disease in the organ donor manifesting with coronary anomalies in the transplan...
Source: Pediatric Transplantation - November 8, 2012 Category: Transplant Surgery Authors: Joshua Friedland‐Little, Ranjit Aiyagari, Robert J. Gajarski, Kurt R. Schumacher Tags: Case Report Source Type: research

CHOP experts describe research in pediatric heart disease
(Children's Hospital of Philadelphia) Physician-researchers from The Children's Hospital of Philadelphia presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions. They described racial disparities in risk factors for sudden cardiac death, imaging modalities and novel approaches to assessing cardiac anomalies, ventricular assist device use, changes in immunosuppressive drugs after pediatric heart transplant, and many other topics.
Source: EurekAlert! - Social and Behavioral Science - November 8, 2012 Category: Global & Universal Source Type: news

Inferior Vena Cava Interruption In A Liver Transplantation Deceased Donor
Inferior vena cava (IVC) abnormalities occur in less than 1% of patients, being their incidence higher in case of congenital heart diseases (1). IVC embryologic development is a complex process involving the formation and regression of different venous systems (2). Pre‐existing IVC abnormalities have been well described in liver transplant recipients (3), but not in the case of donors. © 2012 John Wiley & Sons A/S
Source: Liver International - November 8, 2012 Category: Gastroenterology Authors: Giovanni Battista Levi Sandri, Quirino Lai, Francesco Nudo, Massimo Rossi Tags: Liver International Images Source Type: research

Outcome of kidney paired donation transplantation to increase donor pool and to prevent commercial transplantation: a single-center experience from a developing country
Conclusion The incidences of acute rejection, patient/graft survival rates were acceptable in our KPD program and, therefore, we believe it should be encouraged. These findings are valuable for encouraging participation of KPD pairs and transplant centers in national KPD program. It should be promoted in centers with low-deceased donor transplantation. Our study findings are relevant in the context of Indian government amending the Transplantation of Human Organs Act to encourage national KPD program. To our knowledge, it is largest single-center report from India. Content Type Journal ArticleCatego...
Source: International Urology and Nephrology - November 7, 2012 Category: Urology & Nephrology Tags: International Urology and Nephrology Source Type: research

Candidal psoas abscess following persistent pyuria in a renal transplant recipient
We report a 42-year-old male renal transplant recipient with prolonged pyuria and candiduria followed by candidal psoas abscess formation. The treatment consisted of prolonged antifungal therapy along with percutaneous drainage. However, eventually, a surgical drainage had to be performed for the successful eradication. Content Type Journal ArticleCategory Nephrology - Case ReportPages 1-5DOI 10.1007/s11255-012-0316-8Authors Nurgul Ozgur, Division of Nephrology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, TurkeyNurhan Seyahi, Division of Nephrology, Department of In...
Source: International Urology and Nephrology - November 7, 2012 Category: Urology & Nephrology Tags: International Urology and Nephrology Source Type: research

Growth Of Cystic Kidney Halted
Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders, affecting one in every 1,000 people and responsible for up to ten percent of patients on dialysis worldwide. The disease is characterized by the development of cysts that lead to progressive kidney failure and necessitate dialysis or a kidney transplant in most patients aged around fifty. Moreover, the persistent cyst growth causes high blood pressure and painful complications...
Source: Health News from Medical News Today - November 7, 2012 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes
Conclusions/interpretation During PIT, E2 synergistic actions contribute to enhancing human islet-graft survival, revascularisation and functional mass. This study identifies E2 as a short-term treatment to improve PIT. Content Type Journal ArticleCategory ArticlePages 1-12DOI 10.1007/s00125-012-2764-1Authors S. Liu, Department of Medicine, Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Tarry 15-761, Chicago, IL 60611, USAG. Kilic, Department of Medicine, Division of Endocrinology, Metabolism and Molecular Me...
Source: Diabetologia - November 7, 2012 Category: Endocrinology Tags: Diabetologia Source Type: research

The engineer and the clinician: Understanding the work output and troubleshooting of the HeartMate II rotary flow pump
The HeartMate II (Thoratec, Pleasanton, Calif) left ventricular assist device has been implanted in more than 10,000 patients worldwide. It has been approved by the Food and Drug Administration for both destination and bridge-to-transplant therapy. The design has changed from the original HeartMate XVE, a volume-displacement (VD) pump, to the current continuous, axial, and rotary pump. The pump has a high-speed, axially oriented, impeller with a helical vane geometry driven by a 3-phase, direct current electrical motor. Device flows are not measured directly but rather are inferred from pump speed and pump power consumptio...
Source: The Journal of Thoracic and Cardiovascular Surgery - November 7, 2012 Category: Cardiovascular & Thoracic Surgery Authors: W. Scott Arnold, Kevin Bourque Tags: Expert Review Source Type: research

Comparison of Erythrocyte Membrane Fatty Acid Contents in Renal Transplant Recipients and Dialysis Patients
Conclusions: FA contents of erythrocyte membranes were significantly different in KTP compared with dialysis patients. These differences may have been associated with improved dietary intake and immunosuppression after kidney transplantation.
Source: Transplantation Proceedings - November 7, 2012 Category: Transplant Surgery Authors: J.S. Oh, S.M. Kim, Y.H. Sin, J.K. Kim, Y. Park, H.R. Bae, Y.K. Son, H.K. Nam, H.J. Kang, W.S. An Tags: Candidates Source Type: research

Electrochemically deposited gentamicin-loaded calcium phosphate coatings for bone tissue integration.
Conclusions: Electrochemical technology can be advantageously exploited in order to obtain coatings for bone-contact prostheses with tailored antibacterial properties. PMID: 23138703 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - November 7, 2012 Category: Transplant Surgery Authors: Altomare L, Visai L, Bloise N, Arciola CR, Ulivi L, Candiani G, Cigada A, Chiesa R, Nardo LD Tags: Int J Artif Organs Source Type: research

Epidemiology and new developments in the diagnosis of prosthetic joint infection.
Abstract Although prosthetic joint infection (PJI) is a rare event after arthroplasty, it represents a significant complication that is associated with high morbidity, need for complex treatment, and substantial healthcare costs. An accurate and rapid diagnosis of PJI is crucial for treatment success. Current diagnostic methods in PJI are insufficient with 10-30% false-negative cultures. Consequently, there is a need for research and development into new methods aimed at improving diagnostic accuracy and speed of detection. In this article, we review available conventional diagnostic methods for the diagnosis of PJ...
Source: The International Journal of Artificial Organs - November 7, 2012 Category: Transplant Surgery Authors: Corvec S, Portillo ME, Pasticci BM, Borens O, Trampuz A Tags: Int J Artif Organs Source Type: research

Comparative study of rendezvous techniques in post-liver transplant biliary stricture.
CONCLUSION: The rendezvous technique involving use of the KMP catheter was a fast and safe method for placing inside stents in patients with LDLT biliary stricture that represents a viable alternative to the guidewire rendezvous technique. PMID: 23139613 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - November 7, 2012 Category: Gastroenterology Authors: Chang JH, Lee IS, Chun HJ, Choi JY, Yoon SK, Kim DG, You YK, Choi MG, Han SW Tags: World J Gastroenterol Source Type: research

Corrigendum
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Tags: Corrigendum Source Type: research

Lipid metabolism and oxidative stress in children after liver transplantation treated with sirolimus
Abstract Lipid disturbances are one of the most frequent side effects of SRL; however, clinical consequences are not known. The aim of the study was to evaluate the risk of AS in children after LTx treated with SRL. In 17 children with median age 13.2 yr (1.9–17.9) who received SRL on average for 4.1 yr (s.d. ± 2.9) we measured and compared with age‐matched healthy control group (n = 45) lipid parameters and markers of AS: ADMA, oxyLDL, GSH, GPx, TC, TG, HDL cholesterol, LDL cholesterol, VLDL cholesterol, ApoAI, ApoB, ApoE, lipoprotein (a) (Lp(a)). We found no major differences in cholesterol, cholesterol in lip...
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Irena Jankowska, Piotr Czubkowski, Piotr Socha, Aldona Wierzbicka, Mikołaj Teisseyre, Joanna Teisseyre, Joanna Pawłowska Tags: Original Article Source Type: research

Long‐term outcomes of living donor kidney transplants in pediatric recipients following laparoscopic vs. open donor nephrectomy
Abstract We compared long‐term outcomes of LDKT in pediatric recipients following either laparoscopic (LDN) or ODN. In our retrospective single‐center study, we compared 38 pediatric LDKT recipients of a laparoscopically procured kidney with a historic ODN group comprising 17 pediatric recipients. In our center, the first pure laparoscopic non‐hand‐assisted LDN for a pediatric LDKT recipient was performed in June 2001. Demographic data of donors and recipients were comparable between groups. Mean follow‐up was 64 months in the LDN group and 137 months in the ODN group. Patient survival was comparable between gr...
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Lyubov Chaykovska, Serdar Deger, Jan Roigas, Andre Lenz, Poline Lioudmer, Lisa T. Kothmann, Frank Friedersdorff, Dominik Müller, Antje Kasper, Markus Giessing, Ahmed Magheli, Carsten Kempkensteffen, Anja Lingnau, T. Florian Fuller Tags: Original Article Source Type: research

Acute graft‐versus‐host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single‐center experience during 10 yr
Abstract a‐GvHD may complicate allogeneic HSCT. In this retrospective single‐center study, we evaluated incidence and risk factors of a‐GvHD in 197 consecutive allogeneic pediatric HSCTs applying Glucksberg and NIH a‐GvHD classifications. Among 179 eligible transplants, the cumulative incidence of grade 0–I a‐GvHD was 48% and grade II–IV was 52%. None of the considered variables significantly influenced the incidence of grade II–IV a‐GvHD. Malignancy and myeloablation were associated with an increased risk of classic a‐GvHD (p < 0.01). Seventy‐two percentage of children are alive, with a signific...
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Maura Faraci, Ilaria Caviglia, Erika Biral, Giuseppe Morreale, Stefano Giardino, Lucia Garbarino, Elio Castagnola, Giorgio Dini, Edoardo Lanino Tags: Original Article Source Type: research

Metabolic syndrome and endocrine dysfunctions after HSCT in children
Abstract MS and endocrine dysfunction(s) are common well‐recognized complications after HSCT. We retrospectively analyzed our data on 160 patients with a median age at transplant of five yr (0.3–23), who had been followed for a median of seven yr (range 3–18) at Nationwide Children's Hospital after transplant. Dyslipidemia and MS were seen in 13% and 7.5% patients, respectively, and 58% of these patients were <20 yr of age. Twelve patients met the criteria for diagnosis of MS, but four of these did not meet the International Diabetic Federation or WHO criteria. Variation in the diagnostic criteria for MS leadin...
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Rajinder Bajwa, Micah Skeens, Amy Garee, Yongjie Miao, Sandeep Soni, Daniel Pietryga, Thomas Gross, Amanda Termuhlen Tags: Original Article Source Type: research

The kidney in pediatric liver transplantation: An updated perspective
Abstract CKD continues to detract from the success of improved survival in pediatric liver transplantation, and its presence is likely under recognized. Here we review the literature regarding the prevalence, etiology, and management of renal dysfunction in pediatric liver transplant recipients. Long‐term studies suggest the prevalence of CKD to be 25–38% by 5–10 yr post‐transplant. While important, sole use of serum creatinine overestimates renal function in this population. Screening for and treatment of persistent proteinuria and hypertension as well as minimization of nephrotoxic insults are the mainstays to d...
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Robyn Greenfield Matloff, Ronen Arnon, Jeffrey M. Saland Tags: Review Article Source Type: research

Endoscopy in the management of pancreaticobiliary complications after liver, intestine, or composite visceral transplantation in children
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: William E. Berquist Tags: Editorial Source Type: research

Current status of donation after cardiac death in children in China
Source: Pediatric Transplantation - November 7, 2012 Category: Transplant Surgery Authors: Shan Zheng, Zhen Shen Tags: Editorial Source Type: research

The youngest ever patient to have a lung transplant for Wegener's disease decides to train as a doctor
Ayesha Ahmed, 19, from Newcastle, suffers from Wegener's disease, an inflammation of the blood vessels which attacks her lungs. She received a double lung transplant last year.
Source: the Mail online | Health - November 6, 2012 Category: Consumer Health News Source Type: news

Prediabetes No Barrier to Kidney Donation (CME/CE)
SAN DIEGO (MedPage Today) -- Patients with prediabetes may still be eligible to serve as kidney donors, making more organs available for transplant, researchers said here.
Source: MedPage Today Meeting Coverage - November 6, 2012 Category: Journals (General) Source Type: news

Studies Investigate Health Concerns Related To Kidney Donation And Racial Disparities Faced By Children Needing Transplants
Three studies presented during the American Society of Nephrology's Annual Kidney Week provide new information related to kidney transplantation - specifically, the post-transplant health of kidney donors and the racial disparities faced by children in need of transplants. Recent studies suggest that hypertension and diabetes are more prevalent in black versus white donors, but no comparisons have been made to healthy non-donors, so the risk attributable to donation remains unknown...
Source: Health News from Medical News Today - November 6, 2012 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Ventricular Assist Devices: Is Destination Therapy a Viable Alternative in the Non-Transplant Candidate?
Abstract The topic of this article, stated a more familiar way, is whether left ventricular assist devices (LVADs) are ready for ‘Primetime’ as a therapeutic option in and of themselves. In order to provide an update and insight on this question, we briefly review from where the field has come, and in more detail describe its current state and where we are heading. We believe the short answer to this question is ‘Yes’, but like many things, a short answer is not adequate. Here we attempt to deliver a more comprehensive answer, providing some historical context, outlining the great achievements that h...
Source: Current Heart Failure Reports - November 6, 2012 Category: Cardiology Tags: Current Heart Failure Reports Source Type: research

Antifungal activity against Candida biofilms.
Abstract Candida species have two distinct lifestyles: planktonic, and surface-attached communities called biofilms. Mature C. albicans biofilms show a complex three-dimensional architecture with extensive spatial heterogeneity, and consist of a dense network of yeast, hyphae, and pseudohyphae encased within a matrix of exopolymeric material. Several key processes are likely to play vital roles at the different stages of biofilm development, such as cell-substrate and cell-cell adherence, hyphal development, and quorum sensing. Biofilm formation is a survival strategy, since biofilm yeasts are more resistant to ant...
Source: The International Journal of Artificial Organs - November 6, 2012 Category: Transplant Surgery Authors: Iñigo M, Pemán J, Del Pozo JL Tags: Int J Artif Organs Source Type: research

Influence of prophylactic antibiotics on tissue integration versus bacterial colonization on poly(methyl methacrylate).
Conclusions: These findings are in line with the recalcitrance of biofilms against antibiotic treatment observed clinically, and represent another support for the use of in vitro co-culture models in mimicking the clinical situation. PMID: 23138708 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - November 6, 2012 Category: Transplant Surgery Authors: Subbiahdoss G, Aleyt T, Kuijer R, Busscher HJ, van der Mei HC Tags: Int J Artif Organs Source Type: research

Illness perceptions and treatment perceptions of patients with chronic kidney disease: Different phases, different perceptions?
CONCLUSIONS: Findings suggest that illness and treatment perceptions vary across the CKD trajectory. This indicates that perceptions are amenable to influences and that interventions might potentially be helpful in influencing them in order to improve outcomes. STATEMENT OF CONTRIBUTION: What is already known on this subject? Dialysis patients' perceptions of illness understanding and illness symptoms vary over the first year on dialysis. Established haemodialysis patients' perceptions of illness understanding, emotional response and treatment control vary over a 2-year period. Certain illness perceptions as well as treatm...
Source: British Journal of Health Psychology - November 6, 2012 Category: Psychiatry & Psychology Authors: Jansen DL, Heijmans MJ, Rijken M, Spreeuwenberg P, Grootendorst DC, Dekker FW, Boeschoten EW, Kaptein AA, Groenewegen PP Tags: Br J Health Psychol Source Type: research

Epididymis microlithiasis and semen abnormalities in young adult kidney transplant recipients
Summary Microlithiasis of the epididymis is a rare ultrasound finding in the general population, but the incidence of calcifications in various organs of patients with end‐stage renal disease (ESRD) is extremely high. The aim of this study was to describe epididymal microlithiasis in 22 previously dialysed patients who received kidney transplantations at a median age of 19 years (range 9–30). The patients underwent scrotum ultrasonography, semen analysis and laboratory tests (renal function, sexual hormones, Ca, P and PTH) and were administered the International Index of Erectile Function questionnaire. Seventeen pres...
Source: Andrologia - November 6, 2012 Category: Urology & Nephrology Authors: G. Bozzini, L. Lunelli, M. Berlingheri, E. Groppali, L. Carmignani Tags: Original Article Source Type: research

Effects of hydrogen sulphide in an experimental model of renal ischaemia–reperfusion injury
Conclusion:Hydrogen sulphide offers a promising new approach to ameliorating renal IRI with potential translation into a number of clinical settings, including renal transplantation. Copyright © 2012 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - November 6, 2012 Category: Surgery Authors: J. P. Hunter, S. A. Hosgood, M. Patel, R. Rose, K. Read, M. L. Nicholson Tags: Original Article Source Type: research

Intraoperative continuous hemodiafiltration with selective venous drainage of ischemic limbs
We report two cases of acute limb ischemia with threatened myonephropathic metabolic syndrome (MNMS) in which continuous hemodiafiltration (CHDF) was started before revascularization with selective drainage from the clamped femoral vein of ischemic limb and return of processed blood into the contralateral femoral vein. It was aimed to optimise the removal of metabolites which were produced by myolysis following reperfusion as well as to minimize the deviation of metabolites into the systemic circulation. Both cases had uneventful postoperative course without MNMS and the limbs were salvaged. Content Type Journal A...
Source: Journal of Artificial Organs - November 5, 2012 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: research

Cystic kidney growth curbed
Autosomal-dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders, affecting one in every 1,000 people and responsible for up to ten percent of patients on dialysis worldwide. The disease is characterized by the development of cysts that lead to progressive kidney failure and necessitate dialysis or a kidney transplant in most patients aged around fifty. Moreover, the persistent cyst growth causes high blood pressure and painful complications. Although we have known about the disease for over a century and its genetic basis for almost 20 years, there was no effective treatment until now.
Source: ScienceDaily Headlines - November 5, 2012 Category: Science Source Type: news

Genetics & Genomics: Detection of Heart Transplant RejectionGenetics & Genomics: Detection of Heart Transplant Rejection
Can a noninvasive genetic test diagnose heart allograft rejection? Personalized Medicine
Source: Medscape Today Headlines - November 5, 2012 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news