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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 17.

Generalized Periodic Epileptiform Discharges Herald Impending Seizures (P02.241)
CONCLUSIONS: The detection of GPEDs is important, as such discharges can herald impending seizures and warrant further monitoring. Previous studies have demonstrated that up to 90% of patients with GPEDs can have seizures within the next 48 hours. Although uncommon in children, GPEDs can be detected at any age. As our case demonstrates, cerebral visual impairment can result from seizure activity.Disclosure: Dr. Moseley has nothing to disclose. Dr. Wirrell has received research support from the Mayo Foundation. Dr. Nickels has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moseley, B., Wirrell, E., Nickels, K. Tags: P02 Clinical Neurophysiology: EEG and IONM Source Type: research

Radicular Claudication (P02.227)
CONCLUSIONS: The parameters of F-wave and H-reflex seem to be useful in early detection of radicular compression before constituted radiculopathy appears. Mechanical gravitational compression of the lowest lumbar roots in upright position in obese patients seems to be the major cause of the disorder. We propose the term of radicular claudication instead of neural claudicaiotn as most appropriate to this clinical situation, we also formulate diagnostic criteria for this condition.Disclosure: Dr. Niezgoda has nothing to disclose. Dr. Kozubski has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Niezgoda, A., Kozubski, W. Tags: P02 Clinical Neurophysiology: EMG Source Type: research

Myotonic Discharges Help Detect Clinically Unsuspected Myotonic Dystrophy, Type 2 (P02.222)
CONCLUSIONS: 1. Patients with DM2 may present without specific symptoms or physical signs. 2. Delay in diagnosis is common in these patients. 3. EMG evidence of myotonic discharges facilitates the diagnosis of DM2. 4. Early diagnosis may improve education, reduce evaluations, and provide the opportunity for therapy.Disclosure: Dr. Hlubocky has nothing to disclose. Dr. Ross has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hlubocky, A., Ross, M. Tags: P02 Clinical Neurophysiology: EMG Source Type: research

Modulation of Pentylenetetrazole Kindling Induced Learning and Memory Deficit by 5-HT3 Receptor Antagonism (P02.219)
CONCLUSIONS: This study concludes the ameliorative effect of 5HT3 antagonist (ondansetron) in PTZ kindling induced learning and memory deficit. This study creates a rational to explore the use of ondansetron for memory impairment in patients with epilepsy.Supported by: Indian Council of Medical Research (File No. 45/33/2010/PHA-BMS), New Delhi, India.Disclosure: Dr. Mishra has nothing to disclose. Dr. Goel has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mishra, A., Goel, R. Tags: P02 Epilepsy: Novel Therapeutics and Basic Science Source Type: research

Dynamic Changes of Ephrin A5/EphA4 Pathway in the Hippocampal Formation in a Mouse Model of Temporal Lobe Epilepsy (P02.215)
CONCLUSIONS: Ephrin-A5/EphA4 may be a potential pathway to regulate neurogenesis in adult hippocampal formation of temporal lobe epilepsy.Supported by: National Natural Science Foundation of China(81100967), Specialized Research Fund for the Doctoral Program of Higher Education(20110162120002).Disclosure: Dr. Li has nothing to disclose. Dr. Shu has nothing to disclose. Dr. Wu has nothing to disclose. Dr. Liu has nothing to disclose. Dr. Yang has nothing to disclose. Dr. Xiao has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Li, Y., Shu, Y., Wu, Q., Liu, T., Yang, H., Xiao, B. Tags: P02 Epilepsy: Novel Therapeutics and Basic Science Source Type: research

Walking Away from Myasthenia Gravis (P02.208)
CONCLUSIONS: Our supervised training study program is well tolerated and safely produces 4-fold > higher workload capacity. Fitness and functional gains from this pilot study are promising and support further investigations of exercise to improve fitness, gait efficiency, and functional performance for MG patients.Supported by: Myasthenia Gravis Foundation of America Pilot Grant and Baltimore Veterans Administration Rehabilitation Research and Development: Maryland Exercise and Robotics Center of Excellence Pilot Study.Disclosure: Dr. Hafer-Macko has nothing to disclose. Dr. Macko has nothing to disclose. Dr. Nadel has ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hafer-Macko, C., Macko, R., Nadel, R., Atallah, C., Schmidt, M. Tags: P02 Autoimmune and Congenital Myasthenia Source Type: research

Decreased Cerebrospinal Fluid (CSF) Hypocretin 1 (Orexin A) Levels after Whole Brain Radiotherapy: A Candidate Biomarker for Radiation Encephalopathy (P02.164)
CONCLUSIONS: There is a significant reduction of CSF hypocretin after whole brain radiation. This is the first study to address the pathophysiology of post-radiation hypersomnolence. These findings may be important in determining the risk for specific patients and identifying therapies.Supported by: NINDS R25 Resident Research Training Grant (5R25NS070682-03; NPP) and A Reason To Ride Research Fund (ETW). We acknowledge the kindness of Dr. Lin Ling, Dr. Emmanuel Mignon's Laboratory and the Narcolepsy Center at Stanford University for running the hypocretin-1 assay.Disclosure: Dr. Pedersen has nothing to disclose. Dr. Lok h...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pedersen, N., Lok, E., Wong, E. Tags: P02 Neuro-Oncology: Basic Science Source Type: research

The Importance of Aquaporin-4 Antibody Assays in Patients beyond the Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorders (P02.156)
CONCLUSIONS: A highly sensitive assay to measure AQP4 antibodies is required to ensure that patients with NMOSD are not misdiagnosed.Supported by: KAKENHI (22229008) of The Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan, and by the Health and Labour Sciences Research Grant on Intractable Diseases (Neuroimmunological Diseases) from the Ministry of Health, Labour and Welfare of Japan.Disclosure: Dr. Sato has received research support from the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan and from Ichiro Kanehara Foundation. Dr. Nakashima has received personal c...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sato, D., Nakashima, I., Takahashi, T., Misu, T., Waters, P., Kuroda, H., Nishiyama, S., Suzuki, C., Takai, Y., Itoyama, Y., Fujihara, K., Aoki, M. Tags: P02 Neuromyelitis Optica Source Type: research

Characterization of NMO and NMOSD Patients with a Late Onset (P02.152)
CONCLUSIONS: LONMO/NMOSD is particularly severe with a high rate of death compared to Early Onset NMO described in the literature. We also confirm the predominance of motor impairment in these patients.Supported by: Public grant from the French Agence Nationale de la Recherche within the context of the Investment for the Future programme, referenced ANR-10-COHO-002.Disclosure: Dr. Collongues has received personal compensation for activities with Biogen Idec, Bayer Schering, Teva Neuroscience, Merck Serono, Sanofi-Aventis Pharmaceuticals, Inc., and Novartis. Dr. Marignier has nothing to disclose. Dr. Jacob has nothing to di...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Collongues, N., Marignier, R., Jacob, A., Siva, A., Paul, F., Zephir, H., Leite, M. I., Akman-Demir, G., Elsone, L., Jarius, S., Papeix, C., Mutch, K., Saip, S., Wildemann, B., Kitley, J., Karabudak, R., Aktas, O., Kuscu, D., Altintas, A., Palace, J., Con Tags: P02 Neuromyelitis Optica Source Type: research

Aquaporin-4 Antibodies Are Not Related to HTLV-1 Associated Myelopathy (P02.140)
CONCLUSIONS: Our results argue both against a role of antibodies to AQP4 in the pathogenesis of HAM/TSP and against an association between HTLV-1 infection and the development of AQP4-Ab. Moreover, the absence of HTLV-1 in all patients with NMOSD suggests that HTLV-1 is not a common trigger of acute attacks in patients with AQP4-Ab positive NMOSD in populations with high HTLV-1 seroprevalence.Supported by: Brazilian government agencies FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo) and CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior).Disclosure: Dr. Von Glehn Silva has nothing to disclose....
Source: Neurology - February 14, 2013 Category: Neurology Authors: Von Glehn Silva, F., Jarius, S., Penalva-de-Oliveira, A., Brandao, C. O., Farias, A., Damasceno, A., Casseb, J., Moraes, A., Longhini, A. L., Wandinger, K.-P., Damasceno, B., Wildemann, B., Santos, L. Tags: P02 Neuromyelitis Optica Source Type: research

Multinational Gilenya™ (Fingolimod) Pregnancy Exposure Registry: Preliminary Results (P02.134)
CONCLUSIONS: Reliable safety data from the registry will be useful for treating and counseling women with MS who have been or may be exposed to fingolimod during pregnancy.Supported by: Novartis Pharma AG, Basel, Switzerland.Disclosure: Dr. Geissbuhler has received personal compensation for activities with Novartis as an employee. Dr. Butzkueven has received personal compensation for activities with Biogen Idec, Novartis for scientific advisory boards, from Novartis, CSL (Australia) as a speaker, conference travel support from Biogen Idec, Novartis. Dr. Butzkueven has received research support from Merck Serono, Biogen Ide...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Geissbuhler, Y., Butzkueven, H., Hernandez-Diaz, S., Koren, G., MacDonald, T., Tilson, H., Starzyk, K., Plana, E., Cremer, M., von Rosenstiel, P., Anand, D., Schlosshauer, R., Yuanyuan, L., Hellwig, K. Tags: P02 Multiple Sclerosis: Pregnancy and Hormonal Influences Source Type: research

Risk Factors for Transverse Myelitis Compared with Multiple Sclerosis, Neuromyelitis Optica, and Other Neurologic Disorders in Pediatric Patients (P02.121)
CONCLUSIONS: Unlike pediatric and adult MS, EBV exposure does not appear to be associated with TM in pediatric patients. Larger studies are needed to confirm this association.Supported by: TM and some NMO sera were provided by the Accelerated Cure/Guthy Jackson Foundation. The Pediatric MS Centers are supported by the NMSS. KW is supported by a grant from the Dean's Office Medical Student Research Program at UCSF. Dr. Graves is supported by the NMSS (Sylvia Lawry award) and the CMSC.Disclosure: Dr. Weinfurtner has nothing to disclose. Dr. Graves has nothing to disclose. Dr. Mowry has received research support from Teva Neu...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Weinfurtner, K., Graves, J., Mowry, E., Krupp, L., Belman, A., Milazzo, M., James, J., Waubant, E. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Differential Diagnosis of Longitudinally Extensive Transverse Myelitis (P02.109)
CONCLUSIONS: NMOSD is the main diagnosis of LETM in our sample. "Idiopathic" NMO-IgG-negative LETM represent 12%, highlighting the role of other assays to study antiaquaporin-4 antibody, as well as, new antibodies associated with LETM, such as anti-MOG. Furthermore, it is essential to maintain a high index of suspicion for different possible and serious etiologies: infectious and vascular LETM may represent a critical subset with distinct therapeutic and prognosis.Disclosure: Dr. Apostolos-Pereira has received personal compensation for travel grants from Biogen Idec. Dr. Marchiori has nothing to disclose. Dr. Dellavance ha...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Apostolos-Pereira, S., Marchiori, P., Dellavance, A., Lucato, L., Jorge, F., Simm, R., Sato, D., Callegaro, D. Tags: P02 Pediatric MS and Other Diseases Source Type: research

Atypical Face Processing in Children with Tuberous Sclerosis Complex (P02.100)
CONCLUSIONS: These promising results demonstrate that children with TSC are slower to process faces, and they lack the hemispheric specialization seen in typical development. We also identify slower face processing in children with TSC and ASD. Here, we have begun to define an electrophysiological biomarker of a perceptual domain critical for normative social development, with the ultimate goal of defining functional pathways to ASD in TSC.Supported by: American Academy of Neurology Clinical Research Training Fellowship: Understanding Neural Correlates of Autism in Children with TSC; DOD CDMRP TSCRP: Characterizing early s...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Jeste, S., Prabhu, S., Gregas, M., Sahin, M., Nelson, C. Tags: P02 Child Neurology I Source Type: research

Adapted Tango Dancing for Parkinson's Disease (PD) Can Be Safely Delivered in Community-Based Settings (P02.079)
CONCLUSIONS: Community-based adapted tango for PD can be safely delivered with high participant satisfaction/retention, and potential for improving balance.Supported by: Dan and Merrie Boone Foundation, The Emory Center for Injury Control, Department of Veterans Affairs (VA) Career Development Award (E7108M; Hackney).Disclosure: Dr. McKee has nothing to disclose. Dr. Hackney has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: McKee, K., Hackney, M. Tags: P02 Ataxia, Parkinson ' s Disease, and Dystonia Source Type: research

A Novel System To Evaluate the Dynamic Cerebellar Motor Learning Capability and Its Application Identifies a Clinical Marker in Cerebellar Ataxias (P02.078)
CONCLUSIONS: We conclude that the present system could be a powerful tool to evaluate cerebellar functions, and it could be also used for the differential diagnosis of ataxic symptoms.Supported by: Grants-in-Aid for Strategic Research Program for the Brain Sciences by the Ministry of Education, Culture Sports, Science and Technology of Japan.Disclosure: Dr. Hashimoto has nothing to disclose. Dr. Ishikawa has nothing to disclose. Dr. Honda has nothing to disclose. Dr. Nagao has nothing to disclose. Dr. Mizusawa has received personal compensation for activities with Tanabemitsubishi Co and Sanofi-Aventis. Dr. Mizusawa has re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hashimoto, Y., Ishikawa, K., Honda, T., Nagao, S., Mizusawa, H. Tags: P02 Ataxia, Parkinson ' s Disease, and Dystonia Source Type: research

Adverse Events with Implantable Deep Brain Stimulators - Trends and Insight from the FDA MAUDE Database, 2001 - 2007 (P02.074)
CONCLUSIONS: The frequency of AEs with DBS devices increased dramatically between 2001 and 2007. Within the accepted limitations of a voluntary database, infection and device malfunction are common AEs and often lead to explantation. More serious events such as death or stroke are uncommon. This study includes larger numbers of AEs than prior published reports and reinforces the need for device registries for long-term safety evaluation.Disclosure: Dr. Diaz has nothing to disclose. Dr. McMurtray has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Diaz, N., McMurtray, A. Tags: P02 Movement Disorders: Dystonia Source Type: research

Can Childhood Comorbidities Be Good Predictors of Functional Outcome in Adults with Tourette Syndrome? A Series of 140 Cases (P02.061)
CONCLUSIONS: In TS associated co-morbidities (ADD or OCD) do not predict functional outcome in adults compared to those without co-morbidities, however, further comprehensive age specific assessment of functional impairment in larger population might be necessary.Disclosure: Dr. Mainali has nothing to disclose. Dr. Velander has nothing to disclose. Dr. Lederman has nothing to disclose. Dr. Erenberg has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Mainali, G., Velander, L., Lederman, R., Erenberg, G. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Interim Analysis of an Open-Label, Multi-Center Study of Ecopipam, a Dopamine D1 Receptor Antagonist, for Tic Reduction in Adults with Tourette Syndrome (P02.058)
CONCLUSIONS: In this open-label study, oral ecopipam appeared to reduce tic severity without causing weight gain. To confirm treatment safety and efficacy, further double blind, placebo-controlled randomized trials in children and in adults with TS are warranted.Supported by: Psyadon Pharmaceuticals, Inc.Disclosure: Dr. Gilbert has received personal compensation in an editorial capacity for Pediatrics Review and Education Program. Dr. Gilbert has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals. Dr. Budman has received research support from Psyadon Pharmaceuticals and Otsuka Pharmaceuticals...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gilbert, D., Budman, C., Singer, H., Kurlan, R., Kwan, R., Chipkin, R. Tags: P02 Restless Legs Syndrome, Tourette Syndrome, and Dystonia Source Type: research

Assessment of Stroke Risk Factors in Southern Arizona (P02.054)
CONCLUSIONS: Despite a higher incidence of stroke, Hispanic concern regarding stroke risk factors is much lower than non-Hispanics. This suggests that knowledge linking risk factors for stroke and incident stroke may be lacking in Hispanic communities. Lessened concern regarding stroke risk factors may contribute to an increase incidence in stroke and to a worse outcome in this population. Hispanics increased interest in health promotion programs may afford one approach to addressing this problem. This data suggest that despite historically worse stroke outcomes, preventative efforts may be beneficial in raising stroke ris...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Nokes, B., Sim, Y., Byreddy, S., Chong, J., Drake, K., Labiner, D., Coull, B. Tags: P02 Cerebrovascular Disease II Source Type: research

Predictive Risk Factors of In-Hospital Mortality Following Acute Stroke in the United States: Data from the Nationwide Inpatient Database, 2006-2010 (P02.015)
CONCLUSIONS: The rate of in-hospital mortality is relatively high following acute stroke (8.42%). We identified multiple risk factors of in-hospital mortality in acute stroke patients. The strongest risk factor is the type stroke (hemorrhagic). The present finding suggests that patients at increased risk of mortality can be identified and additional treatment for prevention might be warranted.Disclosure: Dr. Naderi has nothing to disclose. Dr. Abcede has nothing to disclose. Dr. Al-Khoury has nothing to disclose. Dr. Mozaffar has received personal compensation for activities with California Stem Cell Inc., NuFactor, Cresce...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Naderi, N., Abcede, H., Al-Khoury, L., Mozaffar, T., Jain, V. Tags: P02 Cerebrovascular Disease II Source Type: research

Thrombolytic Utilization in Ischemic Stroke Is Significantly Higher in US Hospitals with Neurology Residency Program (S02.006)
CONCLUSIONS: Stroke care at NR hospitals is associated with an increased thrombolytic utilization rate. The increased tPA utilization at NR between 2002-2006 may be related to the rapid increase in Primary Stroke Centers across the country.Disclosure: Dr. Moradiya has nothing to disclose. Dr. Grant has nothing to disclose. Dr. Valsamis has nothing to disclose. Dr. Levine has received personal compensation in an editorical capacity for MEDLINK.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moradiya, Y., Grant, J., Valsamis, H., Levine, S. Tags: S02 Acute Stroke Therapy Source Type: research

Stigma toward Mental and Neurological Disorders Is Common in a Hispanic Community (P02.003)
CONCLUSIONS: Stigma toward neuropsychiatric disorders is common in this Hispanic community. In our study, age, gender and level of education did not correspond to differences in prejudice, underlying the complexity of this problem. More studies are needed to evaluate the true implications of stigma toward neuropsychiatric diseases.Supported by: 1. Department of Neurological Sciences, University of Nebraska Medical Center; 2. The Carole Davis Memorial Fund. University of Nebraska Medical Center.Disclosure: Dr. Gharzai has nothing to disclose. Dr. Xu has nothing to disclose. Dr. Torres-Russotto has received personal compensa...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Gharzai, L., Xu, L., Torres-Russotto, D. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Rate of Utilization and Determination of Withdrawal of Care among Acute Ischemic Stroke Patient Treated with Thrombolytics (P02.002)
CONCLUSIONS: Our results identify several individual and institution related factors that determine the use of "withdrawal of care" among thrombolytic treated ischemic stroke patients. The excessively high mortality and resource utilization mandates a more evidence based policy for "withdrawal of care" in these patients.Disclosure: Dr. Suri has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Gilani has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Suri, M. F., Adil, M., Gilani, W., Qureshi, A. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

A Live Patient Simulation Model for Neurology Residents and Fellows to Effectively Communicate Bad News (P02.001)
CONCLUSIONS: Utilizing simulated patients to train residents and fellows on how to deliver bad news is an effective way to prepare learners for real-time clinical scenarios.Disclosure: Dr. Guntur has nothing to disclose. Dr. Vota has nothing to disclose. Dr. Wong has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Guntur, P., Vota, S., Wong, J. Tags: P02 Ethics, Pain, and Palliative Care Source Type: research

Effect of Test Setting on Baseline Clinical Reaction Time Assessment in Collegiate Athletes (P01.267)
CONCLUSIONS: Baseline RTclin results in collegiate athletes did not differ when athletes were tested in a group versus individual setting. This suggests that group testing, which may be more practical during pre-participation physical examinations, is acceptable. The significant order effect identified suggests that a learning effect may be present. Additional practice trials should be considered to decrease the influence of this learning effect on baseline RTclin results.Supported by: University of Michigan Summer Biomedical Research Program.Disclosure: Dr. Ladue has nothing to disclose. Dr. Eckner's institution has recei...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Ladue, T., Eckner, J., Kutcher, J. Tags: P01 Sports Neurology Source Type: research

Risk Factors for Post-Traumatic Headaches after Sport-Related TBI in a Pediatric Subspecialty Clinic Population (P01.264)
CONCLUSIONS: Careful risk factor assessment may help to identify patients more likely to develop persistent PTHA who would benefit from early pediatric neurology clinic referral and intervention.Supported by: The Morris A. Hazan 2011-2012 Friends Fellowship, Child Neurology Foundation, Today and Tomorrow's Children Fund, UCLA BIRC.Disclosure: Dr. Choe has nothing to disclose. Dr. Fischer has nothing to disclose. Dr. Yudovin has nothing to disclose. Dr. McArthur has nothing to disclose. Dr. Giza has received personal compensation for activities with Medical Education Speakers Bureau and Medicolegal consultation.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choe, M., Fischer, J., Yudovin, S., McArthur, D., Giza, C. Tags: P01 Sports Neurology Source Type: research

A Model for Developing and Incorporating a Sports Neurology Program in Neurology Residency Programs (P01.258)
CONCLUSIONS: As the demand for medical clearance of athletes by neurologists or other health care providers increase, it will be essential that neurologists understand how to diagnose and manage athletes suspected of sustaining sports concussions or other sports neurologic injuries. Incorporating this program into neurology residency programs will not only assist with the increasing demand for medical clearance but will ensure athletes safely return to play without placing them at an increased risk for post-concussive syndrome (PCS), second impact syndrome (SIS), and chronic traumatic encephalopathy (CTE).Disclosure: Dr. M...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Madey, J., Williams, N., Bodle, J., Williams, E., Edwards, J. Tags: P01 Sports Neurology Source Type: research

Sport-Related Concussion in Youth: Impact on Behavioral Functioning (P01.256)
CONCLUSIONS: These results suggest that there are measurable increases by parent report of problems with aspects of behavioral and emotional functioning within 6 months following pediatric SRC in patients presenting to a specialty TBI clinic. Of particular interest are changes in domains that involve internalizing problems, which may be less apparent to parents as well as health care providers. Tools such as the CBCL can be helpful to draw attention to areas of post-TBI difficulty that may need additional intervention.Supported by: Child Neurology Foundation/Winokur Family Foundation, Today's and Tomorrow's Children Fund, ...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hartonian, I., Babikian, T., Yudovin, S., Valino, H., Fischer, J., Giza, C. Tags: P01 Sports Neurology Source Type: research

Ischemic Stroke Related to Severe Iron-Deficiency Anemia in Adults May Benefit from Blood Transfusion (P01.232)
CONCLUSIONS: Prevalence of IDA is 1-20%; it is 3.9% in our AIS population and is often related to untreated uterine bleeding. As described in the pediatric population, severe IDA may be an underlying mechanism of ischemic stroke in adults, therefore, efforts must be undertaken to identify and treat the cause of the anemia. While patients with AIS and severe IDA may receive TPA, blood transfusion may be considered as an adjuvant therapy.Supported by: SPOTRIAS P50 NS044227 & NIH Training Grant 5T 32NS0077412-12.Disclosure: Dr. Choi has nothing to disclose. Dr. Sanchez-Rotunno has nothing to disclose. Dr. Gonzales has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choi, E., Sanchez-Rotunno, M., Gonzales, N. Tags: P01 Cerebrovascular Disease I Source Type: research

Raising Awareness about Acute Stroke Care in Chicago: The Primary Stroke Center (PSC) Mini-Internship Program (P01.220)
CONCLUSIONS: The MIP's work to-date presents a powerful approach for enhancing stroke health and treatment awareness. Involving community members, particularly minorities, requires approaches that recognize unique cultural and medical features, and can improve awareness and treatment of strokes.Disclosure: Dr. Aggarwal has nothing to disclose. Dr. Prabhakaran has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Aggarwal, N., Prabhakaran, S. Tags: P01 Cerebrovascular Disease I Source Type: research

Patients with Stroke and Dysphagia: Demographics and Trends in Percutaneous Endoscopic Gastrotomy Tube Use in Stroke Patients in the United States from 1988-2010 (P01.219)
CONCLUSIONS: The use of PEG tubes has increased over time in US hospital admissions for acute stroke, and was associated with multiple comorbidities, greater length of stay and age > 74. This shows the increasing awareness of post-stroke dysphagia.Disclosure: Dr. Johnson has nothing to disclose. Dr. Dubinsky has received personal compensation for activities with Allergan, Inc. Dr. Dubinsky has received research support from Allergan Pharmaceuticals, Medivation Pharmaceuticals, and from the National Institutes of Health.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Johnson, K., Dubinsky, R. Tags: P01 Cerebrovascular Disease I Source Type: research

Seizures and Preventive Antiepileptic Treatment in Patients with Multiple Sclerosis and Natalizumab Associated Progressive Multifocal Leukoencephalopathy (P01.186)
CONCLUSIONS: Seizures seem to be more common in NAT-PML, than in other types of-PML. Seizures occurred most commonly 2 months after diagnosis of PML during IRIS. This may explain higher seizure frequency in NAT-PML. PAT decreased the incidence of seizures significantly. Although data are limited we propose that NAT-PML patients may receive PAT before development of IRIS. Larger datasets are needed.Disclosure: Dr. Hoepner has nothing to disclose. Dr. Dahlhaus has nothing to disclose. Dr. Kollar has nothing to disclose. Dr. Zurawski has nothing to disclose. Dr. Chan has received personal compensation for activities with Baye...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Hoepner, R., Dahlhaus, S., Kollar, S., Zurawski, B., Chan, A., Kleiter, I., Gold, R., Hellwig, K. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Endovascular Treatment for Chronic Cerebrospinal Venous Insufficiency in Patients with Multiple Sclerosis: Patient-Reported Outcomes (PRO) (P01.182)
CONCLUSIONS: Our findings indicate that ET procedures for CCSVI are associated with subjective reports of improvement of various symptoms by many patients without any corresponding objective change in neurological evaluations as measured by neurologist-derived EDSS scores. These uncontrolled and unblinded observations do not provide any credible evidence of a true benefit from ET for MS.Disclosure: Dr. Baharnoori has nothing to disclose. Dr. Wong has nothing to disclose. Dr. Hohol has received personal compensation for activities with Berlex, Biogen Idec, Serono, Inc., and Teva Neuroscience. Dr. O'Connor has received perso...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Baharnoori, M., Wong, S., Hohol, M., O'Connor, P. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Adverse Event Profile of Alemtuzumab over Time in Active Relapsing-Remitting Multiple Sclerosis Patients Who Experienced Disease Activity While on Prior Therapy (CARE-MS II) (P01.174)
CONCLUSIONS: The rate of AEs was similar across treatment arms except during the months with alemtuzumab administration where the excess was mostly attributable to IARs. The incidence of endocrine disorders was higher in the second year consistent with delayed onset.Supported by: Genzyme, a Sanofi company and Bayer Healthcare Pharmaceuticals.Disclosure: Dr. LaGanke has served as a consultant for Acorda Therapeutics, Bayer, Biogen Idec, Cephalon, EMD Serono, Genzyme, Novartis, Pfizer, Questcor, Strativa, Teva, and UCB. Dr. Arnold has received personal compensation or research support from Bayer Healthcare, Biogen Idec, Gene...
Source: Neurology - February 14, 2013 Category: Neurology Authors: LaGanke, C., Arnold, D., Cohen, J., Coles, A., Confavreux, C., Fox, E., Hartung, H., Havrdova, E., Selmaj, K., Weiner, H., Miller, T., Twyman, C., Lake, S., Margolin, D., Panzara, M., Compston, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Disease Course and Outcome of 15 Monocentrically Treated Natalizumab-Associated Progressive Multifocal Leukoencephalopathy (PML) Patients (P01.168)
CONCLUSIONS: Although the clinical outcome of natalizumab-treated PML patients is much better than in HIV-associated PML-patients, this may be further improved by treatment at reference centers using standardized therapy regimens. Systematic studies of follow-up immunotherapies after MS-PML are critically needed.Disclosure: Dr. Dahlhaus has nothing to disclose. Dr. Hoepner has nothing to disclose. Dr. Chan has received personal compensation for activities with Bayer Schering, Biogen Idec, Merck Serono, Sanofi-Aventis and Teva Neuroscience as a speaker or consultant. Dr. Chan has received research support from the German Mi...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Dahlhaus, S., Hoepner, R., Chan, A., Kleiter, I., Adams, O., Schroeder, A., Hellwig, K., Gold, R. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

Safety, Tolerability and Patient Evaluation of Peginterferon beta-1a Administered Via a Single-Use Autoinjector in Relapsing Multiple Sclerosis: Data from the Phase 3 ATTAIN Study (P01.167)
CONCLUSIONS: Results will help to establish the safety and tolerability profiles of peginterferon beta-1a administered via autoinjector in MS patients, and evaluate patient perceptions of the injection process using the autoinjector.Supported by: Biogen Idec Inc.Disclosure: Dr. Calabresi has received personal compensation for activities with Biogen Idec, Teva Neuroscience, Genzyme Corporation, Vaccinex, Vertex, and Novartis. Dr. Calabresi has received research support from the National Institutes of Health, the National Multiple Sclerosis Society, Nancy Davis Foundation, Biogen Idec, Vertex, Genentech, Inc., Abbott, and Ba...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Calabresi, P., Liu, S., Seddighzadeh, A., Sperling, B., Hung, S., Deykin, A. Tags: P01 Multiple Sclerosis: Treatment Safety Source Type: research

{alpha}A Study of Regional Variants of Guillain-Barre Syndrome: A Prospective Study from a Tertiary Teaching Hospital of South India (P01.131)
CONCLUSIONS: αGBS 'Variants' accounted for 8.4% of GBS patients in our institute. There was strong association with antecedent infection. There were some seasonal trends with predilection in winter and rainy seasons. PCB Variant had poorer outcome while Paraparetic Variant had better prognosis.Disclosure: Dr. Pokalkar has nothing to disclose. Dr. Narisetty has nothing to disclose. Dr. Polusani has nothing to disclose. Dr. Kamera has nothing to disclose. Dr. Chekuri has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pokalkar, D., Narisetty, V., Polusani, R., Kamera, S., Chekuri, M. Tags: P01 Peripheral Nerve: Acute Inflammatory and Nutritional Source Type: research

Vitamin D Status in Migraine Patients: A Case-Control Study (P01.079)
CONCLUSIONS: We did not find any association between migraine and vitamin D status; also severity of headaches was not related to vitamin D level. Younger people with vitamin D deficiency were more susceptible to migraine.Disclosure: Dr. Zandifar has nothing to disclose. Dr. Zandifar has nothing to disclose. Dr. Masjedi has nothing to disclose. Dr. Banihashemi has nothing to disclose. Dr. Asgari has nothing to disclose. Dr. Manouchehri has nothing to disclose. Dr. Zandifar has nothing to disclose. Dr. Saadatnia has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Zandifar, S., Zandifar, A., Masjedi, S., Banihashemi, M., Asgari, F., Manouchehri, N., Zandifar, E., Saadatnia, M. Tags: P01 Headache: Clinical Presentation and Therapeutics Source Type: research

No Olfactory Deficit in Episodic Cluster Headache (P01.075)
CONCLUSIONS: No lack of olfactory performance was observed in the patient cohort regarding odor threshold, discrimination, identification or TDI-overall performance. Furthermore no lateralization in nasal chemosensory performance could be identified in side comparison in all domains. This is in contrast to previous findings and pulls CH apart from being a multisensory disorder.Disclosure: Dr. Naegel has nothing to disclose. Dr. Buckanie has nothing to disclose. Dr. Holle has received research support from Grünenthal. Dr. Rosenow has nothing to disclose. Dr. Knake has nothing to disclose. Dr. Diener has received person...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Naegel, S., Buckanie, N., Holle, D., Rosenow, F., Knake, S., Diener, H., Katsarava, Z., Obermann, M. Tags: P01 Headache: Clinical Presentation and Therapeutics Source Type: research

Non-Interventional Study of the Switch from Oral Treatment to Rotigotine Transdermal System in Patients with Parkinson's Disease and Gastrointestinal Symptoms (P01.067)
CONCLUSIONS: This study suggests that a switch from oral PD medication to transdermal dopaminergic therapy (rotigotine) may improve pre-existing GI symptoms among patients with PD. Further studies are needed to confirm this finding. An ongoing double-blind trial investigating the effects of rotigotine transdermal system on GI motility will investigate this further.Supported by: UCB Pharma, Monheim am Rhein, Germany.Disclosure: Dr. Woitalla has received personal compensation for activities with UCB Pharma, GlaxoSmithKline, Inc. and Orion Pharma as a consultant. Dr. Lauterbach is an employee of UCB Pharma. Dr. Berkels has re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Woitalla, D., Lauterbach, T., Berkels, R., Grieger, F., Timmermann, L., Kassubek, J. Tags: P01 Movement Disorders: Parkinson ' s Disease Therapy Source Type: research

Thiamine Administration within University-Affiliated Hospitals: A Retrospective Review of Prescribing Practices (P01.057)
CONCLUSIONS: Oral thiamine continues to be prescribed to patients at risk of deficiency. Protocols prioritizing parenteral administration may improve compliance with evidence-based recommendations. Additional study of factors that may improve rates of parenteral administration is required.Disclosure: Dr. Day has nothing to disclose. Dr. Ladak has nothing to disclose. Dr. Curley has nothing to disclose. Dr. del Campo has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Day, G., Ladak, S., Curley, K., del Campo, C. Tags: P01 Neurologic Manifestations: Therapeutics Source Type: research

Cognitive Difference Associated with High-Altitude Flying in Pilots (P01.052)
CONCLUSIONS: Extreme hypobaric exposure is associated with a mild difference in general cognition, processing accuracy, reasoning and memory compared to AFP controls not exposed to extreme altitudes. Although there is a statistically significant change, U2 pilots continue to perform highly on cognitive assessments. Additional study is underway to explain the mechanism of this difference.Disclosure: Dr. Rasmussen has nothing to disclose. Dr. Tate has nothing to disclose. Dr. Kochunov has nothing to disclose. Dr. Sherman has nothing to disclose. Dr. McGuire has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Rasmussen, J., Tate, D., Kochunov, P., Sherman, P., McGuire, S. Tags: P01 Neurologic Manifestations: Therapeutics Source Type: research

Significant Improvements on Muscle Performance and Walking Capacity after Progressive Resistance Training (PoRT) and Core and Stability Training (CoaST) for People with MS (P01.036)
CONCLUSIONS: Progressive resistance training (PoRT) and core and stability training (CoaST) in groups could improve muscle performance and walking distance for people in MS. Both physical interventions indicate to improve independence in daily life.Supported by: Novartis Pharma GmbH, Germany.Disclosure: Dr. Jolk has received personal compensation for activities with Novartis as a consultant. Dr. Artiguenave has nothing to disclose. Dr. Bernhardt has received personal compensation for activities with Bayer, Biogen Idec, Merck Serono, Novartis, Sanofi-Aventis Pharmaceuticals, Inc., and Teva Neuroscience. Dr. Bernhardt has re...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Jolk, C., Alcantara, R., Bernhardt, L., Marziniak, M., Platen, P. Tags: P01 Clinical Neurophysiology: Therapeutics Source Type: research

Awareness of Drug-Drug Interactions between Synthetic Hormones and Anti-Epileptic Medications: A Survey of Neurology, Obstetrics and Gynecology, Internal Medicine, and Psychiatry Residents (P01.034)
CONCLUSIONS: Awareness regarding important interactions between AEDs and hormonal contraception is low in all specialties. As these medications continue to be prescribed for conditions other than epilepsy, it is vital that physicians become aware of these interactions in order to provide optimal care to women of childbearing age. Further education through the development of guidelines and interactive educational materials is important and recommended during residency training.Disclosure: Dr. Sahay has nothing to disclose. Dr. Garic has nothing to disclose. Dr. Gawron has nothing to disclose. Dr. Hammond has nothing to disc...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Sahay, M., Garic, I., Gawron, L., Hammond, C., Kennedy, J., Macken, M., Schuele, S., Stika, C., York, S., Gerard, E. Tags: P01 Clinical Neurophysiology: Therapeutics Source Type: research

Unexpected Burst-Suppression during Sedation with Anesthetic Agents in the ICU (P01.027)
CONCLUSIONS: Two-thirds of ICU patients receiving anesthetic agents for sedation who underwent EEG monitoring were found to be in burst-suppression, indicative of profound brain inactivation and over-sedation. This finding highlights the difficulty of consistently achieving target sedation levels in routine clinical practice. Improved monitoring and management strategies are needed to avoid the adverse effects of sedative overdosing.Disclosure: Dr. Pati has nothing to disclose. Dr. Rosenthal has nothing to disclose. Dr. Cash has nothing to disclose. Dr. Hochberg has nothing to disclose. Dr. Brown has nothing to disclose. D...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pati, S., Rosenthal, E., Cash, S., Hochberg, L., Brown, E., Westover, M. Tags: P01 Neurocritical Care: Clinical Neurophysiology/Therapeutics Source Type: research

Timing Matters: Early Post Traumatic Seizures in a Pediatric Population (P01.024)
CONCLUSIONS: EPTS that began >1 hour after injury were related to greater TBI severity, injury mechanism and worse outcomes. Seizures that occurred within the first hour after head trauma were not associated with TBI severity, injury mechanism or worse short-term outcomes. Very early post-TBI seizure events may include impact seizures as well as non-epileptic events (such as brief posturing, syncope, etc), which are distinct from medically observed EPTS and have different prognostic implications.Supported by: National Epifellows Foundation, Thrasher Research Foundation, Today's and Tomorrow's Children Fund, Child Neurol...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Su, M., McArthur, D., Lerner, J., Arndt, D., Matsumoto, J., Valino, H., Yudovin, S., Leung, M., Giza, C. Tags: P01 Neurocritical Care: Clinical Neurophysiology/Therapeutics Source Type: research

Management of Early Severe Hypertension in Acute Intracerebral Hemorrhage in Primary Stroke Centers vs. Non-Stroke Center Hospitals (P01.022)
CONCLUSIONS: Antihypertensives were initiated earlier for ICH at PSCs, however steroid utilization was no different. This suggests that routing stroke patients to PSCs may improve timeliness of antihypertensive therapy for ICH and greater education requiring avoidance of steroids is desirable even within PSCs.Disclosure: Dr. Flinders has nothing to disclose. Dr. Sanossian has received personal compensation for activities with Boehringer-Ingelheim as speaker. Dr. Starkman has received research support from the National Institutes of Health, Lundbeck, Mitsubishi, and NTI. Dr. Liebeskind has received personal compensation for...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Flinders, A., Sanossian, N., Starkman, S., Liebeskind, D., Eckstein, M., Stratton, S., Pratt, F., Hamilton, S., Olivas, E., Chatfield, F., Conwit, R., Saver, J. Tags: P01 Neurocritical Care: Clinical Neurophysiology/Therapeutics Source Type: research

Abnormal Tactile Pressure Perception in Parkinson's Disease: A Perceptual Grasp (P01.010)
CONCLUSIONS: These results demonstrate that patients with PD have a perceptual grasp for the pressure exerted by tactile stimuli. This perceptual grasp may be a disorder of disengagement induced by frontal-executive dysfunction that is often associated with PD.Supported by: In part by the AAN 2012 Medical Student Summer Research Scholarship.Disclosure: Dr. Kesayan has nothing to disclose. Dr. Williamson has nothing to disclose. Dr. Falchook has received personal compensation for activities with the University of Florida College of Medicine, the Institute for Advancement of Human Behavior, and PeerView Institute. Dr. Okun h...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Kesayan, T., Williamson, J., Falchook, A., Okun, M., Malaty, I., Rodriguez, R., White, K., Hauser, R., Heilman, K. Tags: P01 Behavioral Neurology: Attention and Executive Functions Source Type: research

It's the Right Brain: The Impact of Education on Higher-Level Brain Organization in Healthy Elders Performing an Executive Function Task (P01.006)
CONCLUSIONS: The rlatFEF is a critical hub of a cortical oculomotor network that subserves executive function in healthy elders. The organization of this network during task performance is strongly associated with prior education. Because education is often used a surrogate measure of cognitive reserve, these results provide a potential mechanism for how cognitive function is preserved in aging.Disclosure: Dr. Pa has nothing to disclose. Dr. Dutt has nothing to disclose. Dr. Mirsky has nothing to disclose. Dr. Heuer has nothing to disclose. Dr. Kong has nothing to disclose. Dr. Trujillo has nothing to disclose. Dr. Keselma...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Pa, J., Dutt, S., Mirsky, J., Heuer, H., Kong, E., Trujillo, A., Keselman, P., Seeley, W., Gazzaley, A., Kramer, J., Miller, B., Boxer, A. Tags: P01 Behavioral Neurology: Attention and Executive Functions Source Type: research