Urology & Nephrology
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Cystodistension: No Standards And No Benefits-Survey Of UK Practice - When Data Is Limited, The Place Of Hydrodistention And Hunner's Lesion Ablation
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UroToday.com - Cystoscopy with hydrodistention is not practiced in any standardized fashion despite proposals by the National Institute of Diabetes Digestive and Kidney Disorders (NIDDK) 2 decades ago and more recently the European Society for the Study of Interstitial Cystitis (ESSIC) to establish such standards... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 20, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Further Benefits Of Noscapine For Prostate Cancer Revealed By StudyEmail this article to a colleague.
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New research has revealed a major breakthrough in the use of cough medicine ingredient noscapine as a prophylactic treatment for prostate cancer. The study shows that noscapine inhibited tumor growth in mice and also limited the spread of tumors without causing any side effects. The collaborative pre-clinical laboratory research was conducted by Dr... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 20, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
The Impact Of Positive Surgical Margins On Mortality Following Radical Prostatectomy During The Prostate Specific Antigen EraEmail this article to a colleague.
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UroToday.com - A positive surgical margin (PSM) after radical prostatectomy (RP) for prostate cancer (CaP) is a known risk factor for disease progression. A PSM is reported to occur in 19%-50% of patients undergoing RP. In most studies, biochemical recurrence (BCR) is the primary endpoint used to assess the impact of margin status... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 20, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Endoscopic extraperitoneal radical prostatectomy: critical analysis of outcomes and learning curveEmail this article to a colleague.
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Study Type [ndash] Therapy (case series)Level of Evidence 4OBJECTIVE To assess the outcomes and learning curve of extraperitoneal endoscopic radical prostatectomy (EERP) using cumulative summation charts from a single tertiary referral centre.PATIENTS AND METHODS The data from 300 consecutive men with localized prostate cancer who underwent EERP at Western General Hospital, Edinburgh, UK, between February 2006 and July 2009 were prospectively maintained in a database. The data collected included demographic details, perioperative outcomes, complications and follow-up for functional and oncology outcomes. The learning curve...
Source: BJU International - March 20, 2010 Category: Urology & Nephrology Authors: Alan S. McNeill, Ghulam Nabi, Lisa McLornan, Jonathan Cook, Prasad Bollina, Jens-Uwe Stolzenberg Source Type: journals
Nephrolithotomy With Early Tube Removal Favored Over Tubeless ApproachEmail this article to a colleague.
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In treating renal stones, early removal of the nephrostomy tube after percutaneous nephrolithotomy (PCNL) improves clearance rates and may offer other advantages over a tubeless approach, the results of a small study suggest. Reuters Health Information (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - March 19, 2010 Category: Urology & Nephrology Tags: Urology Source Type: info
Stop Using Sling for Male Stress Incontinence: StudyEmail this article to a colleague.
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Transobturator sling suspension had a very low long-term cure rate in men with post-prostatectomy stress incontinence, Dutch researchers report in the April issue of the Journal of Urology. Reuters Health Information (Source: Medscape Urology Headlines)
Source: Medscape Urology Headlines - March 19, 2010 Category: Urology & Nephrology Tags: Urology Source Type: info
Fatigue In Hormone-Naive Prostate Cancer Patients Treated With Radical Prostatectomy Or Definitive RadiotherapyEmail this article to a colleague.
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UroToday.com - In the online edition of Prostate Cancer and Prostatic Diseases, a group of Norwegian investigators report on the prevalence of chronic fatigue (CF) in hormone-naïve patients who underwent radical prostatectomy (RP) or radiotherapy (RT) at least one year prior to the survey... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 19, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Impact Of Ethnicity On Primary Treatment Choice And Mortality In Men With Prostate Cancer: Data From CaPSUREEmail this article to a colleague.
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UroToday.com - In the Journal of Clinical Oncology, a group of investigators use the CaPSURE database to investigate the association of pretreatment clinical factors with treatment choice, by ethnicity. CaPSURE is a primarily community based dataset of more than 13,000 men with biopsy-proven prostate cancer (CaP)... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 19, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
ProPSA Measurements In Serum And Tissue Are Associated With Treatment Necessity Among Men Enrolled In Expectant Management For Prostate CancerEmail this article to a colleague.
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UroToday.com - We identified 75 men with available tissue from an initial diagnostic biopsy - of whom 71 had both benign-adjacent and cancer biopsy tissue as well as serum available from the time of diagnosis... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 19, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Expression of E-series prostaglandin (EP) receptors and urodynamic effects of an EP4 receptor antagonist on cyclophosphamide-induced overactive bladder in ratsEmail this article to a colleague.
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To investigate the expression of four subtypes of E-series prostaglandin (EP1[ndash]EP4) receptors and the urodynamic effects of an EP4 receptor antagonist (AH23848) in cyclophosphamide (CYP)-induced overactive bladder (OAB) in rats, as intravesical prostaglandin E2 (PGE2) induces OAB via activation of EP receptors and sensitization of afferent nerves. Experimental and control rats were injected with CYP (200 mg/kg, intraperitoneally) or saline, respectively. Continuous cystometrograms (CMGs) were performed 48 h after CYP or saline injection under urethane anaesthesia. AH23848 was given intravenously at doses of 0.01 and 0...
Source: BJU International - March 19, 2010 Category: Urology & Nephrology Authors: Yao-Chi Chuang, Naoki Yoshimura, Chao-Cheng Huang, Moya Wu, Pradeep Tyagi, Michael B. Chancellor Source Type: journals
Improving informed consent for patients undergoing radical prostatectomy using multimedia techniques: a prospective randomized crossover studyEmail this article to a colleague.
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Study Type [ndash] Therapy (RCT)Level of Evidence 1b To compare the comprehension gained by standard consent (SC) vs a unique interactive multimedia presentation (IMP), for radical prostatectomy (RP), as informed consent for RP requires that the patient understands the procedure and potential complications. Forty patients undergoing RP were prospectively randomized to SC or IMP, followed by a 26-question test on critical aspects of the surgery and its implications. The groups were crossed over and re-tested, with a subsequent statistical analysis. SC involved typical verbal interaction and consultation with physicians and ...
Source: BJU International - March 19, 2010 Category: Urology & Nephrology Authors: Dennis Gyomber, Nathan Lawrentschuk, Peter Wong, Frank Parker, Damien M. Bolton Source Type: journals
Beyond the Abstract - Upgrading of Gleason score 6 prostate cancers on biopsy after ...Email this article to a colleague.
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BERKELEY, CA (UroToday.com) - Regarding prostate cancer (PCa), histological estimation of needle biopsy specimens from the prostate is the first... (Source: UroToday)
Source: UroToday - March 18, 2010 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info
Beyond the Abstract - Molecular characterization of upper urinary tract tumours, by Laura ...Email this article to a colleague.
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BERKELEY, CA (UroToday.com) - Upper urinary tract urothelial carcinoma (UTUC)... (Source: UroToday)
Source: UroToday - March 18, 2010 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info
Importance of hypogonadism and testosterone replacement therapy in current urologic practice: A ...Email this article to a colleague.
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Department of Urology, University Campus Bio-Medico, Rome, Italy. (Source: UroToday)
Source: UroToday - March 18, 2010 Category: Urology & Nephrology Tags: Browse Categories - Androgen Deficiency Source Type: info
The effect of statin therapy on testosterone levels in subjects consulting for erectile ...Email this article to a colleague.
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Andrology Unit, Department of Clinical Physiopathology, University of Florence, Florence Italy. (Source: UroToday)
Source: UroToday - March 18, 2010 Category: Urology & Nephrology Tags: Browse Categories - Erectile Dysfunction (ED) Source Type: info
Subcutaneous cod liver oil injection for penile augmentation: Review of literature and report ...Email this article to a colleague.
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Urology Department, Hamad General Hospital, Doha, Qatar. (Source: UroToday)
Source: UroToday - March 18, 2010 Category: Urology & Nephrology Tags: Browse Categories - Erectile Dysfunction (ED) Source Type: info
Preoperative Criteria To Select Patients For Bilateral Nerve Sparing Robotic-Assisted Radical Prostatectomy (RALP)Email this article to a colleague.
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UroToday.com - Erectile dysfunction is one of the most relevant functional complications following radical prostatectomy. No study had analyzed the predictors of potency recovery in a series of patients undergoing robot-assisted laparoscopic radical prostatectomy (RALP). Moreover, Briganti et al... (Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today)
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today - March 18, 2010 Category: Urology & Nephrology Tags: Erectile Dysfunction / Premature Ejaculation Source Type: news
Laparoscopic Radical Nephrectomy For Renal Cell Carcinoma: Oncological Outcomes At 10 Years Or MoreEmail this article to a colleague.
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In this study, however, we were able to address the remaining concern of long-term oncological outcomes after laparoscopic radical nephrectomy. In 73 patients with kidney cancer undergoing laparoscopic radical nephrectomy and followed for mean 11... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 18, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Association Of Interleukin-18 Gene Polymorphisms With Calcium Oxalate Kidney Stone DiseaseEmail this article to a colleague.
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UroToday.com - In the past few years, we have been working to explore the possible gene single nucleotide polymorphisms (SNPs) as genetic makers for renal stone diseases. Calcium oxalate urolithiasis is a multi-factorial disease. The majority are idiopathic, indicating the absence of any identifiable clinical cause of the disease... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 18, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Functional Remodeling Of Benign Human Prostatic Tissues In Vivo By Spontaneously Immortalized Progenitor And Intermediate CellsEmail this article to a colleague.
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UroToday.com - Adult tissue regeneration or remodeling is suggested to initiate from multipotent stem and/or progenitor cells. We recently reported two new human adult non-tumorigenic prostatic epithelial cell lines NHPrE1 and BHPrE1, which were generated and characterized in our laboratory... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 18, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Beyond the Abstract - A pharmacogenetic study of docetaxel and thalidomide in patients with ...Email this article to a colleague.
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BERKELEY, CA (UroToday.com) - Docetaxel is the current standard of care for men with recurrent castrate resistant prostate cancer (CRPC)... (Source: UroToday)
Source: UroToday - March 17, 2010 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info
Editorial - Strategies for managing fibromyalgiaEmail this article to a colleague.
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BERKELEY, CA (UroToday.com) -
What Can We Learn From Other... (Source: UroToday)
Source: UroToday - March 17, 2010 Category: Urology & Nephrology Tags: Browse Categories - IC/PBS/BPS/HBS Source Type: info
Redefining urinary tract infections by bacterial colony counts - AbstractEmail this article to a colleague.
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Department of Paediatric Nephrology, Royal Victoria Infirmary, Newcastle NE1 4LP, United Kingdom. (Source: UroToday)
Source: UroToday - March 17, 2010 Category: Urology & Nephrology Tags: Browse Categories - Infections Source Type: info
Genome-based expression profiling study of Hunner's ulcer type interstitial cystitis: An array ...Email this article to a colleague.
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Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital and Chang Gung University, School of Medicine, 5 Fu-Hsing Street,... (Source: UroToday)
Source: UroToday - March 17, 2010 Category: Urology & Nephrology Tags: Browse Categories - IC/PBS/BPS/HBS Source Type: info
Plasma chitotriosidase activity and arteriogenic erectile dysfunction: Association with the ...Email this article to a colleague.
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Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran. (Source: UroToday)
Source: UroToday - March 17, 2010 Category: Urology & Nephrology Tags: Browse Categories - Erectile Dysfunction (ED) Source Type: info
Modalities for Imaging of Prostate CancerEmail this article to a colleague.
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Prostate cancer is the second most common cause of cancer deaths among males in the United States. Prostate screening by digital rectal examination and prostate-specific
antigen has shifted the diagnosis of prostate cancer to lower grade, organ confined
disease, adding to overdetection and overtreatment of prostate cancer. The new challenge
is in differentiating clinically relevant tumors from ones that may otherwise never have
become evident if not for screening. The rapid evolution of imaging modalities and the
synthesis of anatomic, functional, and molecular data allow for improved detection and
characterization of pros...
Source: Advances in Urology - March 17, 2010 Category: Urology & Nephrology Source Type: journals
For Hans-Jürgen Glander on the occasion of his 65th birthdayEmail this article to a colleague.
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(Source: Andrologia)
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: Uwe Paasch, Sonja Grunewald Tags: CONGRATULATORY MESSAGE Source Type: journals
Emerging Therapies in Castrate-Resistant Prostate CancerEmail this article to a colleague.
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Abstract Prostate cancer is the most common cancer in men in the United States, and despite screening and early treatment, more than
27,000 men are predicted to die of the disease this year, almost all of whom will die of castrate-resistant, metastatic cancers
that have progressed despite androgen deprivation therapy, also known as hormonal therapy. In recent years, an increased understanding
of molecular mechanisms of prostate cancer progression and castration resistance has led to improved treatment strategies.
This review focuses on emerging therapies for the treatment of castrate-resistant prostate cance...
Source: Current Urology Reports - March 17, 2010 Category: Urology & Nephrology Tags: Current Urology Reports Source Type: journals
Therapeutic Potential Of Adult Bone Marrow-Derived Mesenchymal Stem Cells In Prostate Cancer Bone MetastasisEmail this article to a colleague.
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UroToday.com - Adult bone marrow-derived mesenchymal stem cells (MSC) have been shown to inhibit tumor growth in various studies. Although MSC express MHC class I molecules, they lack expression of co-stimulatory molecules and suppress T-cell response, which gives them the utility to overcome a wide range of immunologic barriers... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Risk Factor Analysis In A Contemporary Cystectomy Cohort Using Standardized Reporting Methodology And Adverse Event CriteriaEmail this article to a colleague.
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UroToday.com - Despite significant improvements in surgical technique, preoperative preparation and perioperative care since the inception of radical cystectomy (RC), the complication rate associated with this operation remains high. Patients requiring RC are elderly with considerable associated comorbidities due to the strong association of cigarette smoking and urothelial bladder carcinoma... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
RNA Quality In Fresh Frozen Prostate Tissue From Patients Operated With Radical ProstatectomyEmail this article to a colleague.
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UroToday.com - Discovery of new genes that may be biomarkers for prostate cancer (CaP) often are identified by microarray analysis of RNA obtained from radical prostatectomy tissue. In the Scandinavian Journal of Clinical and Laboratory Investigation, Dr. Helena Bertilsson and colleagues analyze what variables impact RNA quality and ultimately lead to the discovery of biomarkers from CaP tissue... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
Fesoterodine For The Treatment Of Urinary Incontinence And Overactive BladderEmail this article to a colleague.
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UroToday.com - The first placebo-controlled superiority trial between 2 antimuscarinic agents was recently performed comparing fesoterodine 8mg to tolterodine ER 4mg and placebo. The study was a 12 week randomized, double-blind, double-dummy, placebo-controlled trial in patients with OAB and at least 1 urgency urinary incontinence (UUI) episode per 24 hours on a 3 day diary at baseline... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Minorities At Greater Risk For Kidney DiseaseEmail this article to a colleague.
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Certain ethnic minorities, including African Americans and Hispanics, are at a higher risk than the general population for developing potentially life-threatening chronic kidney disease (CKD) , which has been linked to higher rates of diabetes and high blood pressure, according to the National Kidney Foundation (NKF)... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Do Weather Conditions Influence The Onset Of Renal Colic? A Novel Approach To AnalysisEmail this article to a colleague.
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UroToday.com - In our study we demonstrated an association between the onset of renal colic and exposure to hot and dry weather, particularly when temperatures rose above 27° C and relative humidity fell below 45%. A clear evidence on this issue is still lacking in the specific literature, despite a number of papers recently published on this topic [1]... (Source: Urology / Nephrology News From Medical News Today)
Source: Urology / Nephrology News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Urology / Nephrology Source Type: news
Transurethral Resection Of The Prostate In Saline Versus Nonconductive Solution To Treat Benign Prostatic Hyperplasia: A Randomized Controlled StudyEmail this article to a colleague.
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UroToday.com - For many decades, transurethral resection of the prostate (TURP) has been considered the benchmark of surgical management for BPH. The ideal irrigant for TURP would be a nonconductive medium that does not interfere with diathermy, has a high degree of translucency, has osmolality similar to that of serum, and causes only minimal side effects when absorbed. Traditionally, a 1... (Source: Prostate News From Medical News Today)
Source: Prostate News From Medical News Today - March 17, 2010 Category: Urology & Nephrology Tags: Prostate / Prostate Cancer Source Type: news
[Non-adjustable sling for treatment of male stress urinary incontinence.]Email this article to a colleague.
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Even though the artificial sphincter is still the treatment of choice in the surgical therapy of male stress urinary incontinence, recent developments have introduced numerous minimally invasive treatment options with acceptable clinical results. The male slings have been included into the EAU guidelines for treatment of male stress urinary incontinence. A distinct choice of patients and treatment options will lead to the highest chance of success. Besides the adjustable compressive slings, the non-adjustable and non-compressive AdVance(R) Sling offers a possible option for a functional approach to treatmentratio. A cr...
Source: Der Urologe. Ausg. A - March 17, 2010 Category: Urology & Nephrology Authors: Betz D, Bach P, Gozzi C, Goepel M Tags: Urologe A Source Type: journals
Congress CalendarEmail this article to a colleague.
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(Source: Andrologia)
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Tags: CONGRESS CALENDAR Source Type: journals
Activity of nitric oxide synthase in mature and immature human spermatozoaEmail this article to a colleague.
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Nitric oxide (NO) is known to be involved in multiple signal transduction pathways of male germ cells, including sperm capacitation. In somatic cells, NO production was found to be part of apoptosis signalling. The aim of our study was to further clarify the role of NO in spermatozoa by investigation of NO synthase activity with regard to sperm maturity and sperm apoptosis signalling. Semen specimens from 19 healthy donors were subjected to density gradient centrifugation to separate the predominantly mature and immature sperm fraction. NO synthase activity was evaluated using diaminofluoresceine-2-diacetate by FACS. Apopt...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: C. Roessner, U. Paasch, H.-J. Glander, S. Grunewald Tags: ORIGINAL ARTICLES Source Type: journals
Effects of post-density gradient swim-up on apoptosis signalling in human spermatozoaEmail this article to a colleague.
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The inclusion of apoptotic spermatozoa during assisted reproductive techniques (ART) may be one reason for suboptimal success rates. The aim of our study was to evaluate the potential of routine semen preparation to eliminate spermatozoa with activated apoptosis signalling. Semen samples from 20 infertility patients scheduled for ART procedures were investigated. Following density gradient centrifugation (DGC) and swim-up, aliquots were taken from each sample to analyse motility, Caspase-3 activation (CP3) and integrity of the mitochondrial membrane potential (MMP) using flow cytometry. Aliquots from the neat semen served ...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: S. Grunewald, M. Reinhardt, V. Blumenauer, A. F. Hmeidan, H.-J. Glander, U. Paasch Tags: ORIGINAL ARTICLES Source Type: journals
Impact of chronic viral diseases on semen parametersEmail this article to a colleague.
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The aim of this study was to assess the effect of human immunodeficiency virus (HIV), hepatitis C (HCV) and B (HBV) virus infection on semen parameters. Semen samples were obtained from 27 HCV, 34 HIV, 30 HBV and 41 HCV-HIV-seropositive patients and compared with those of a control population of healthy seronegative subjects. Tests for detection of HIV, HCV and HBV were performed on seminal samples. The sperm concentration was significantly decreased in HCV- and HBV-seropositive males compared to that of controls (P < 0.001). The mean sperm motility (a + b) was significantly decreased in HCV- and HBV-seropositive (P < 0.00...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: F. Lorusso, M. Palmisano, M. Chironna, M. Vacca, P. Masciandaro, E. Bassi, L. Selvaggi Luigi, R. Depalo Tags: ORIGINAL ARTICLES Source Type: journals
Hypoandrogenism related to early skin wound healing resistance in ratsEmail this article to a colleague.
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The purpose of this study was to verify the effect of testosterone depletion on healing of surgical skin wounds at different ages and post-operative periods. Forty-four Wistar male rats were divided into four groups: Group 1Y (n = 11) [ndash] young control, sham-operated rats (30-day old); Group 1A (n = 10) [ndash] adult control, sham-operated rats (3 to 4-month old); Group 2Y (n = 10) [ndash] young rats after bilateral orchiectomy; and Group 2A (n = 11) [ndash] adult rats after bilateral orchiectomy. After 6 months, a linear incision was performed on the dorsal region of the animals. The resistance of the wound healing wa...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: A. Petroianu, D. F. M. Veloso, L. R. Alberti, J. A. Figueiredo, F. H. O. Carmo Rodrigues, B. G. M. Carvalho E Carneiro Tags: ORIGINAL ARTICLES Source Type: journals
The in vitro effects of melatonin on human sperm function and its scavenging activities on NO and ROSEmail this article to a colleague.
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This study aimed at establishing the effects of melatonin treatment on human spermatozoa. Spermatozoa were incubated with 2 mm melatonin (120 min, 37 °C, 5% CO2) after which motility parameters were measured by computer aided motility analysis, while cell viability (PI), intracellular NO (DAF-2/DA) and ROS (DCFH-DA) were assessed using flow cytometry. In vitro melatonin treated samples (n = 12) showed a significantly higher percentage of motile, progressive motile and rapid cells, while simultaneously reducing the number of nonviable spermatozoa when compared with the control. Endogenous NO was significantly decreased, bu...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: S. S. du Plessis, K. Hagenaar, F. Lampiao Tags: ORIGINAL ARTICLES Source Type: journals
Metabolic evaluation of cooled equine spermatozoaEmail this article to a colleague.
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Microscopy has been used in the routine evaluation of sperm metabolism. Nevertheless, it has limited capacity to preview male fertility. As calorimetry may be used to evaluate directly the metabolic activity of a biological system, the aim of this study was to use microcalorimetry as an additive method for sperm metabolism evaluation of cooled equine semen. Two ejaculates of four stallions were collected and motility, viability (eosin 3%) and membrane functional integrity (hyposmotic swelling test) of spermatozoa were evaluated. Sperm samples were processed following different protocols and the metabolism of these samples ...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: A. B. Vasconcelos, M. A. Santana, A. M. C. Santos, M. M. Santoro, M. A. Lagares Tags: ORIGINAL ARTICLES Source Type: journals
Effect of food restriction on ghrelin in adult male rats and its relation to male reproductive hormonesEmail this article to a colleague.
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Ghrelin is an endogenous ligand for growth hormone secretagogue (GHS) receptor (GHS-R). It has recently emerged as an orexigenic food intake controlling signal acting upon hypothalamic centres. To study the effect of food restriction on ghrelin level and its relation to male reproductive hormones, 32 adult male albino rats divided into two groups: Group I (8 rats as a control group) fed ad libitum for 21 days and 24 rats as Group II (food-restricted group) fed 30% of ad libitum intake of food consumed by the control group. Rats were weighed every 3 days. Group II rats were further subdivided into three subgroups: IIa, IIb ...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: H. M. Abou Heif, M. M. Deif, H. K. Abdel Aziz Tags: ORIGINAL ARTICLES Source Type: journals
Long-term ofloxacin testicular toxicity: an experimental studyEmail this article to a colleague.
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The aim of this study was to assess the long-term toxic effect of ofloxacin on the testes and epididymides of 72 adult male albino rats. The rats were divided into group A and group B. Group A, which received ofloxacin for 14 days, was subdivided into two subgroups; LD-14 received low dose 72 mg KBW[minus]1 daily and HD-14 received high dose 216 mg KBW[minus]1 daily. Group B, which received ofloxacin for 28 days, was subdivided into two subgroups; LD-28 received 72 mg KBW[minus]1 and HD-28 received 216 mg KBW[minus]1 daily. Two matched control groups were followed up for 14 and 28 days respectively. The animals were evalua...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: M. A. EL-Harouny, A. A. Zalata, M. E. Naser, H. M. Abo El-Atta, I. M. El-Shawaf, T. Mostafa Tags: ORIGINAL ARTICLES Source Type: journals
SCF and c-kit expression profiles in male individuals with normal and impaired spermatogenesisEmail this article to a colleague.
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The transcription levels of stem cell factor (SCF) and c-kit were examined using real-time RT PCR in interstitial and intratubular cell fractions, as well as in tissue homogenates from normal, azoospermic and neoplasmic patients. Peripheral blood mononuclear cells (PBMC) were used as a systemic control. The observed level of c-kit expression in all investigated groups was generally higher than the expression of SCF. The highest (statistically significant) level of c-kit was noted in testicular tumours (the greater part of which were represented by seminomas) in contrast to SCF mRNA, which may indicate an association betwee...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: M. Bialas, A. Borczynska, N. Rozwadowska, D. Fiszer, W. Kosicki, P. Jedrzejczak, M. Kurpisz Tags: ORIGINAL ARTICLES Source Type: journals
Effect of anion channel blockers on l-arginine action in spermatozoa from asthenospermic menEmail this article to a colleague.
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In earlier studies, we have established that l-arginine enhances motility and metabolic rate in spermatozoa of goat, bull and mouse. In the present study this work was extended to human sperm cells obtained from the semen samples of asthenospermic patients, which are characterised by low motility. The metabolic rate was followed by monitoring the glucose consumption (1-13C glucose as substrate) and the production of lactate in sperm cells, using 13C NMR. The stimulatory effect of l-arginine was neutralised on adding an NO-synthase inhibitor like N[omega]-nitro-l-arginine methyl ester. On the other hand, the inactive d-enan...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: S. Srivastava, A. Agarwal Tags: ORIGINAL ARTICLES Source Type: journals
Leucocytes and intrinsic ROS production may be factors compromising sperm chromatin condensation statusEmail this article to a colleague.
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Considering that the final protection of the DNA against major assaults in terms of chromatin condensation is finalised in the epididymis, it is not known how sperm production of reactive oxygen species (ROS) and inflammatory processes can contribute to protamine deficiency that is predetermined in the testes. Therefore, this study aimed at investigating relationships between poor chromatin condensation, morphology, ROS production, DNA damage and the impact of the presence of leucocytes. In 70 patients, sperm DNA status was determined using TUNEL and chromomycin A3 (CMA3) assays, and ROS-production by means of dihydroethid...
Source: Andrologia - March 17, 2010 Category: Urology & Nephrology Authors: R. Henkel, H. S. Bastiaan, S. Schüller, I. Hoppe, W. Starker, R. Menkveld Tags: ORIGINAL ARTICLES Source Type: journals
Effect of tyrosine kinase inhibitor treatment of renal cell carcinoma on the accumulation of carbonic anhydrase IX-specific chimeric monoclonal antibody cG250Email this article to a colleague.
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To investigate the effect of three different tyrosine kinase inhibitors (TKIs) on the biodistribution of chimeric monoclonal antibody (mAb) cG250, which identifies carbonic anhydrase IX (CAIX), in nude mice bearing human renal cell carcinoma (RCC) xenografts. TKIs represent the best, but still suboptimal treatment for metastatic RCC (mRCC) and combined therapy or sequential therapy might be beneficial. CAIX is abundantly over expressed in RCC and clinical trials have shown abundant and specific tumour accumulation of cG250. Combining a TKI with mAb cG250, involved in a different effector mechanism, might lead to improved t...
Source: BJU International - March 17, 2010 Category: Urology & Nephrology Authors: Jeannette C. Oosterwijk-Wakka, Gürsah Kats-Ugurlu, William P.J. Leenders, Lambertus A.L.M. Kiemeney, Lloyd J. Old, Peter F.A. Mulders, Egbert Oosterwijk Source Type: journals
Beyond the Abstract - Absolute preoperative C-reactive protein predicts metastasis and ...Email this article to a colleague.
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BERKELEY, CA (UroToday.com) - Approximately 30% of patients with localized renal cell carcinoma (RCC) will proceed to develop metastases following... (Source: UroToday)
Source: UroToday - March 16, 2010 Category: Urology & Nephrology Tags: Browse Categories - Beyond the Abstract Source Type: info
