Urology & Nephrology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 22.

Direct economic burden of hepatitis B virus related diseases: evidence from Shandong, China
Conclusion: Hepatitis B imposes considerable economic burden on a family. Our findings will help health policy makers' understanding of the magnitude of the economic burden of HBV-related diseases in China. Evidence from our study also contributes to our understanding of potential benefits to society from allocating more resources to preventing and treating HBV infection, as well as increasing insurance coverage in China. These findings have important policy implications for health care reform efforts currently underway in China focusing on how to reduce the burden of catastrophic disease for its citizens.
Source: BMC Health Services Research - January 31, 2013 Category: Journals (General) Authors: Jingjing LuAiqiang XuJian WangLi ZhangLizhi SongRenpeng LiShunxiang ZhangGuihua ZhuangMingshan Lu Source Type: research

Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor
Key Points Targeted deletion of the gene for macrophage migration inhibitory factor (MIF) delays development of chronic lymphocytic leukemia and prolongs survival in mice. MIF recruits leukemia-associated macrophages to spleen or liver.
Source: Blood - January 31, 2013 Category: Hematology Authors: Reinart, N., Nguyen, P.-H., Boucas, J., Rosen, N., Kvasnicka, H.-M., Heukamp, L., Rudolph, C., Ristovska, V., Velmans, T., Mueller, C., Reiners, K. S., von Strandmann, E. P., Krause, G., Montesinos-Rongen, M., Schlegelberger, B., Herling, M., Hallek, M., Tags: Lymphoid Neoplasia Source Type: research

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis
Conclusion Translational research revealed that TNF superfamily receptors are overexpressed in AH. Fn14, the receptor for TNF-like weak inducer of apoptosis, is selectively upregulated in patients with AH. TNF superfamily receptors could represent a potential target for therapy.
Source: Gut - January 31, 2013 Category: Gastroenterology Authors: Affo, S., Dominguez, M., Lozano, J. J., Sancho-Bru, P., Rodrigo-Torres, D., Morales-Ibanez, O., Moreno, M., Millan, C., Loaeza-del-Castillo, A., Altamirano, J., Garcia-Pagan, J. C., Arroyo, V., Gines, P., Caballeria, J., Schwabe, R. F., Bataller, R. Tags: Hepatitis other Hepatology Source Type: research

Fibroblast growth factor inducible 14 as potential target in patients with alcoholic hepatitis
Alcoholic hepatitis is a distinct clinical entity characterised by jaundice and liver failure that generally occurs after decades of heavy alcohol use. Recovery from alcoholic hepatitis is determined by abstinence from alcohol, the presence of mild clinical symptoms and the implementation of appropriate therapy. Unfortunately, patients with severe alcoholic hepatitis have a high mortality rate of about 40% to 50% despite optimal medical management.1 A significant percentage of patients succumb to bacterial infections with infection-attributed mortality of 12% to 54%2 underscoring the importance of bacterial translocation a...
Source: Gut - January 31, 2013 Category: Gastroenterology Authors: Schnabl, B., Brenner, D. A. Tags: Commentaries Source Type: research

Chemoradiation in patients with isolated recurrent pancreatic cancer - therapeutical efficacy and probability of re-resection
Conclusion: In summary we observed a good therapeutic response with mild to moderate toxicity levels for CRT in RPC. Overall survival and PFS were clearly improved in case of induction of a complete remission (tumor-free biopsies) or after achieving a re-resection, thus providing a curative intended therapy even in case of disease recurrence.
Source: Radiation Oncology - January 31, 2013 Category: Cancer & Oncology Authors: Daniel HabermehlIngo BrechtFrank BergmannThomas WelzelStefan RiekenJens WernerPeter SchirmacherMarkus BüchlerJürgen DebusStephanie Combs Source Type: research

Fenugreek seeds, a hepatoprotector forage crop against chronic AlCl3 toxicity
Conclusion: This study highlighted the hepatotoxicity of AlCl3 through biochemical and histological parameters in one hand and the hepatoprotective role of fenugreek seeds on the other hand. Thus this work could be a pilot study which will encourage farmers to use fenugreek seeds as a detoxifying diet supplement for domestic animals.
Source: BMC Veterinary Research - Latest articles - January 31, 2013 Category: Veterinary Research Authors: Yosra Belaïd-NouiraHayfa BakhtaZohra HaouasImen Flehi-SlimFadoua NeffatiMohamed Fadhel NajjarHassen Ben Cheikh Source Type: research

Production of hepatocyte-like cells from human pluripotent stem cells
Nature Protocols 8, 430 (2013). doi:10.1038/nprot.2012.153 Authors: Nicholas R F Hannan, Charis-Patricia Segeritz, Thomas Touboul & Ludovic Vallier Large-scale production of hepatocytes from a variety of genetic backgrounds would be beneficial for drug screening and to provide a source of cells to be used as a substitute for liver transplantation. However, fully functional primary hepatocytes remain difficult to expand in vitro, and
Source: Nature Protocols - January 31, 2013 Category: Biomedical Science Authors: Nicholas R F HannanCharis-Patricia SegeritzThomas TouboulLudovic Vallier Tags: Protocol Source Type: research

Renal replacement therapy: is it effective in critically ill patients with acute kidney injury?
Utilizing propensity score matching to estimate the efficacy of renal replacement therapy in critically ill patients with acute kidney injury, Clec`h and colleagues failed to demonstrate a reduction of mortality by renal replacement therapy in this ICU subpopulation. However, this statistical technique is subject to hidden bias and there are numerous limitations in the study design, inclusion and description of patients and performance of adequate renal replacement therapy. On the contrary, there is compelling clinical evidence that adequately initiated and dosed renal replacement therapy is life-sustaining even in critica...
Source: Critical Care - January 31, 2013 Category: Intensive Care Authors: Helmut SchifflSusanne Lang Source Type: research

No tumour-initiating risk associated with scAAV transduction in newborn rat liver
& S Conchon
Source: Gene Therapy - January 31, 2013 Category: Genetics & Stem Cells Authors: V GauttierV PichardD AubertC KaeppelM SchmidtN FerryS Conchon Tags: adeno-associated virus rat newborn liver cancer Source Type: research

Suppression of breast tumor growth by DNA vaccination against phosphatase of regenerating liver 3
S Wei Song & C Shou
Source: Gene Therapy - January 31, 2013 Category: Genetics & Stem Cells Authors: J LvC LiuH HuangL MengB JiangY CaoZ ZhouT SheL QuS Wei SongC Shou Tags: PRL-3 DNA vaccine mouse breast cancer Source Type: research

Lack of nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2): Consequences for mouse bladder development and function
ConclusionsComplete loss of Nmnat2 leads to a mature but distended bladder in utero and is not compatible with survival. Moderate loss of Nmnat2 has no effect on bladder development, survival, and has only modest effects on bladder function later in life. Neurourol. Urodynam. © 2013 Wiley Periodicals, Inc.
Source: Neurourology and Urodynamics - January 31, 2013 Category: Urology & Nephrology Authors: Amy N. Hicks, Lysanne Campeau, David Burmeister, Colin E. Bishop, Karl‐Erik Andersson Tags: Original Basic Science Article Source Type: research

Current role of image‐guided robotic radiosurgery (Cyberknife®) for prostate cancer treatment
Conclusions The use of the Cyberknife® system is limited mainly by its pretreatment and maintenance costs. Despite encouraging preliminary results, longer‐term follow‐up and randomized controlled phase III clinical trials are necessary before the Cyberknife® system becomes a standard treatment method.
Source: BJU International - January 31, 2013 Category: Urology & Nephrology Authors: Thomas Seisen, Sarah J. Drouin, Véronique Phé, Jérome Parra, Pierre Mozer, Marc‐Olivier Bitker, Olivier Cussenot, Morgan Rouprêt Tags: Urological Oncology Source Type: research

Renal drug metabolism in humans: The potential for drug‐endobiotic interactions involving cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT).
Abstract Although knowledge of human renal cytochrome P450 (CYP) and UDP‐glucuronosyltransferase (UGT) enzymes and their role in xenobiotic and endobiotic metabolism is limited compared to hepatic drug and chemical metabolism, accumulating evidence indicates that human kidney has significant metabolic capacity. Of the drug metabolising P450s in families 1 to 3, there is definitive evidence for only CYP 2B6 and 3A5 expression in human kidney. CYP 1A1, 1A2, 1B1, 2A6, 2C19, 2D6 and 2E1 are not expressed in human kidney, while data for CYP 2C8, 2C9 and 3A4 expression are equivocal. It is further known that several P450 enzym...
Source: British Journal of Clinical Pharmacology - January 31, 2013 Category: Drugs & Pharmacology Authors: Kathleen M. Knights, Andrew Rowland, John O. Miners Tags: Review Source Type: research

Blood pressure and chronic kidney disease progression in a multi-racial cohort: the Multi-Ethnic Study of Atherosclerosis
Journal of Human Hypertension advance online publication, January 31 2013. doi:10.1038/jhh.2013.2 Author: A Larsson
Source: Journal of Human Hypertension - January 31, 2013 Category: Cardiology Authors: A Larsson Source Type: research

Effects of Dioscorea Polygonoides (Jamaican Bitter Yam) Supplementation in Normocholesterolemic and Genetically Modified Hypercholesterolemic Mice Species
This study provides information on the possible toxicity from overconsumption and paves the way for future studies to establish an effective consumption dosage. With its potent cholesterol‐lowering capabilities, the Jamaican bitter yam can be exploited in the nutraceutical industry and for the development of other value‐added products for everyday consumption such as baked goods and granola bars, giving them a hypocholesterolemic twist.
Source: Journal of Food Biochemistry - January 30, 2013 Category: Food Science Authors: Dewayne Stennett, Frederick Oladeinde, Andrew Wheatley, Joseph Bryant, Lowell Dilworth, Helen Asemota Tags: Full Article Source Type: research

Polyploidization Without Mitosis Improves In Vivo Liver Transduction With Lentiviral Vectors
Human Gene Therapy , Vol. 0, No. 0.
Source: Human Gene Therapy - January 30, 2013 Category: Genetics & Stem Cells Tags: article Source Type: research

B-mode Ultrasound Versus Color Doppler Twinkling Artifact in Detecting Kidney Stones
Journal of Endourology , Vol. 0, No. 0.
Source: Journal of Endourology - January 30, 2013 Category: Urology & Nephrology Tags: article Source Type: research

About predictors of acute kidney injury after lung resection.
PMID: 23340751 [PubMed - in process]
Source: Anesthesia and Analgesia - January 30, 2013 Category: Anesthesiology Authors: Licker MJ, Diaper J, Ellenberger C Tags: Anesth Analg Source Type: research

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study.
Conclusions. CF102 is safe and well-tolerated, showing favorable PK characteristics in Child Pugh A and B HCC patients, justifying further clinical development. PMID: 23299770 [PubMed - in process]
Source: The Oncologist - January 30, 2013 Category: Cancer & Oncology Authors: Stemmer SM, Benjaminov O, Medalia G, Ciuraru NB, Silverman MH, Bar-Yehuda S, Fishman S, Harpaz Z, Farbstein M, Cohen S, Patoka R, Singer B, Kerns WD, Fishman P Tags: Oncologist Source Type: research

Parenchymal Thickness: Does It Have an Impact on Outcomes of Percutaneous Nephrolithotomy
Urol Int (DOI:10.1159/000346336)
Source: Urologia Internationalis : Last 20 articles - January 30, 2013 Category: Urology & Nephrology Source Type: research

Abnormal Glucose Metabolism and Insulin Sensitivity in Chinese Patients with Gitelman Syndrome
Am J Nephrol 2013;37:152–157 (DOI:10.1159/000346708)
Source: American Journal of Nephrology - January 30, 2013 Category: Neurology Source Type: research

Determinants of Cardiovascular Risk in Haemodialysis Patients: Post hoc Analyses of the AURORA Study
Am J Nephrol 2013;37:144–151 (DOI:10.1159/000346710)
Source: American Journal of Nephrology - January 30, 2013 Category: Neurology Source Type: research

Longitudinal Analysis of Vascular Function and Biomarkers of Metabolic Bone Disorders before and after Renal Transplantation
Am J Nephrol 2013;37:126–134 (DOI:10.1159/000346711)
Source: American Journal of Nephrology - January 30, 2013 Category: Neurology Source Type: research

Healthy Behaviors, Risk Factor Control and Awareness of Chronic Kidney Disease
Am J Nephrol 2013;37:135–143 (DOI:10.1159/000346712)
Source: American Journal of Nephrology - January 30, 2013 Category: Neurology Source Type: research

Tengion applies for clinical trial in Sweden
Tengion has submitted an application to begin a Phase 1 clinical trial of its Neo-Kidney Augment product in Sweden, the company said in a news release. Tengion (OTC: TNGN) is the Winston-Salem company that is working to commercialize some of the technologies developed by Dr. Anthony Atala at the Wake Forest Institute for Regenerative Medicine. The company hopes the Neo-Kidney Augment will prove an effective method of regenerating healthy kidney tissue in patients with advanced chronic kidney disease. The…
Source: bizjournals.com Health Care:Hospitals headlines - January 30, 2013 Category: Hospital Management Authors: Matt Evans Source Type: research

Parenchymal Thickness: Does It Have an Impact on Outcomes of Percutaneous Nephrolithotomy?
Urol Int (DOI:10.1159/000346336)
Source: Urologia Internationalis : Last 20 articles - January 30, 2013 Category: Urology & Nephrology Source Type: research

Diagnostic performance of computed tomographic coronary angiography in patients with end-stage renal disease
Conclusion: Results show 64-row multidetector CCTA is highly sensitive and specific in the detection of coronary artery stenosis irrespective of ESRD. Our findings suggest that CCTA is a promising diagnostic tool for the timely detection and/or exclusion of coronary atherosclerosis in patients undergoing pretransplant cardiovascular surveillance.
Source: Coronary Artery Disease - January 30, 2013 Category: Cardiology Tags: Diagnostic Methods Source Type: research

Factors Affecting Survival following Chemoembolization with Doxorubicin-eluting Microspheres for Inoperable Hepatocellular Carcinoma
Conclusions: CLIP score of 1 or lower and necrosis of more than 50% are independent variables affecting PFS and OS after DEB chemoembolization, whereas absence of PV thrombosis and ECOG PS of 1 or lower affected OS but not PFS.
Source: Journal of Vascular and Interventional Radiology : JVIR - January 30, 2013 Category: Radiology Authors: Sanjeeva P. Kalva, Melina Pectasides, Kalpana Yeddula, Suvranu Ganguli, Lawrence S. Blaszkowsky, Andrew X. Zhu Source Type: research

Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies
This article assesses more recent outcomes data regarding PVE, reviews the existing controversies, and reports on novel strategies currently being investigated.
Source: Journal of Vascular and Interventional Radiology : JVIR - January 30, 2013 Category: Radiology Authors: Benjamin J. May, Adam D. Talenfeld, David C. Madoff Source Type: research

Comparing Costs of Robotic, Laparoscopic, and Open Partial Nephrectomy
Journal of Endourology , Vol. 0, No. 0.
Source: Journal of Endourology - January 30, 2013 Category: Urology & Nephrology Tags: article Source Type: research

Ribavirin treatment of acute and chronic hepatitis E: a single center experience
Conclusion Ribavirin is a safe treatment option for HEV infections. However, the optimal dose of ribavirin for the treatment of chronic hepatitis E remains to be determined as treatment failure may occur. © 2013 John Wiley & Sons A/S
Source: Liver International - January 30, 2013 Category: Gastroenterology Authors: S. Pischke, S. Hardtke, U. Bode, S. Birkner, C. Chatzikyrkou, W. Kauffmann, C. Bara, J. Gottlieb, J. Wenzel, M.P. Manns, H. Wedemeyer Tags: Original Article Source Type: research

The absorption, distribution, excretion and toxicity of mesoporous silica nanoparticles in mice following different exposure routes.
This study will be helpful for selecting the appropriate exposed routes for the development of nanomaterials-based drug delivery system for biomedical applications. PMID: 23332175 [PubMed - in process]
Source: Biomaterials - January 30, 2013 Category: Materials Science Authors: Fu C, Liu T, Li L, Liu H, Chen D, Tang F Tags: Biomaterials Source Type: research

Cytoskeletal proteins: shaping progression of hepatitis C virus-induced liver disease.
Abstract Hepatitis C virus (HCV) infection, which results in chronic hepatitis C (CHC) in most patients (70-85%), is a major cause of liver disease and remains a major therapeutic challenge. The mechanisms determining liver damage and the key factors that lead to a high rate of CHC remain imperfectly understood. The precise role of cytoskeletal (CS) proteins in HCV infection remains to be determined. Some studies including our recent study have demonstrated that changes occur in the expression of CS proteins in HCV-infected hepatocytes. A variety of host proteins interact with HCV proteins. Association between CS a...
Source: International Review of Cell and Molecular Biology - January 30, 2013 Category: Cytology Authors: Ghosh S, Kaplan KJ, Schrum LW, Bonkovsky HL Tags: Int Rev Cell Mol Biol Source Type: research

Clinical utility of different botulinum neurotoxin preparations.
Abstract Comparative literature assessing the relative safety and efficacy of different BoNT products is limited. The quantity and quality of data vary by preparation and indication. Clinicians seeking data relevant to the care of patients with specific conditions may find only reports about small numbers of patients with varying symptoms. While a literature search for "botulinum neurotoxins" will yield a large number of publications; only a fraction of these meet criteria for an academic evidence-based review. Patients may have been treated with a different BoNT formulation than that with which the physician is fa...
Source: Toxicon - January 30, 2013 Category: Toxicology Authors: Abrams SB, Hallett M Tags: Toxicon Source Type: research

Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world and its incidence is increasing rapidly. NAFLD is a spectrum ranging from simple steatosis, which is relatively benign hepatically, to nonalcoholic steatohepatitis (NASH), which can progress to cirrhosis. Obesity, insulin resistance, type 2 diabetes mellitus, and dyslipidemia are the most important risk factors for NAFLD. Due to heavy enrichment with metabolic risk factors, individuals with NAFLD are at significantly higher risk for cardiovascular disease. Individuals with NAFLD have higher incidence of type 2 diabetes. The diagn...
Source: Annals of the New York Academy of Sciences - January 30, 2013 Category: Science Authors: Howard C. Masuoka, Naga Chalasani Source Type: research

Serum oxidative–anti‐oxidative stress balance is dysregulated in patients with hepatitis C virus‐related hepatocellular carcinoma
ConclusionHCV positive CLD patients displayed higher oxidative stress and HCV‐HCC patients displayed lower anti‐oxidative state. Anti‐oxidative state depression was associated with liver reservoir‐related data in HCV‐HCC and could be reversed with HCC eradication.
Source: Hepatology Research - January 30, 2013 Category: Internal Medicine Authors: Mamoru Nishimura, Akinobu Takaki, Naofumi Tamaki, Takayuki Maruyama, Hideki Onishi, Sayo Kobayashi, Kazuhiro Nouso, Tetsuya Yasunaka, Kazuko Koike, Hiroaki Hagihara, Kenji Kuwaki, Shinichiro Nakamura, Fusao Ikeda, Yoshiaki Iwasaki, Takaaki Tomofuji, Manab Tags: Original Article Source Type: research

Strain differences in pleural mesothelial cell reactions induced by potassium octatitanate fibers (TISMO) infused directly into the thoracic cavity.
Abstract Although we have previously reported that the fiber-shaped TISMO, morphologically similar to asbestos, can induce a severe mesothelial reaction in A/J mice, it is important to clarify any strain differences. In the present study, female A/J, C3H/HeN, ICR and C57BL/6 mice were therefore employed as test strains. At the beginning of the experiment, all mice underwent a left thoracotomy and direct administration of 3mg of TISMO particles suspended in 0.2ml saline into the left thorax. The experiment was terminated after 21 weeks and all groups were sacrificed and the mesothelium and main organs were examined ...
Source: Experimental and Toxicologic Pathology - January 30, 2013 Category: Pathology Authors: Yokohira M, Nakano Y, Yamakawa K, Kishi S, Ninomiya F, Saoo K, Imaida K Tags: Exp Toxicol Pathol Source Type: research

Application of Interleukin-22 Mediates Protection in Experimental Acetaminophen-Induced Acute Liver Injury.
Abstract Acetaminophen (APAP, paracetamol)-induced hepatotoxicity, although treatable by timely application of N-acetylcysteine, can be fatal. Because it is among the common causes of acute liver failure in intensive care units and in light of its gradually increasing incidence, the need for novel therapeutic strategies aimed at severe intoxication is apparent. Recently, it has been shown that IL-22, a STAT3-activating cytokine, has the capability to mediate liver protection. Herein, the protective potential of IL-22 in murine APAP-induced hepatotoxicity was assessed. Intravenous administration of prophylactic IL-2...
Source: The American Journal of Pathology - January 30, 2013 Category: Pathology Authors: Scheiermann P, Bachmann M, Goren I, Zwissler B, Pfeilschifter J, Mühl H Tags: Am J Pathol Source Type: research

ABCA1 influences neuroinflammation and neuronal death.
Abstract ATP-binding cassette transporter A1 (ABCA1) mediates cellular cholesterol efflux in the brain and influences whole brain cholesterol homeostasis. Activation of liver X receptors (LXRs), transcription factors that increase the expression of cholesterol transport genes including ABCA1, reduces neuroinflammation and pathology in neurodegenerative animal models suggesting that in addition to its involvement in cholesterol transport, ABCA1 may play a role in modulating the inflammatory response in the brain. We investigated the cell-type specific role of ABCA1 in neuroinflammation in vivo using mice specificall...
Source: Neurobiology of Disease - January 30, 2013 Category: Neurology Authors: Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR Tags: Neurobiol Dis Source Type: research

Effects of various drugs (flunixin, pentoxifylline, enoxaparin) modulating micro-rheological changes in cerulein-induced acute pancreatitis in the rat.
Abstract Previously we have investigated the cerulein-induced acute pancreatitis and provided data on its micro-rheological impact in the rat. We hypothesized that non-steroid anti-inflammatory agent flunixin, the xanthine-derivate pentoxifylline and the low molecular weight heparin enoxaparin may have various beneficial effects improving microcirculatory and rheological parameters. In female rats, under general anesthesia, 10 μg/kg cerulein s.c. was administered and 2 hours afterwards microcirculation was tested by laser Doppler flowmetry on the tongue and after performing laparotomy on the small intestine, liver...
Source: Clinical Hemorheology and Microcirculation - January 30, 2013 Category: Hematology Authors: Szentkereszty Z, Kotan R, Kiss F, Klarik Z, Posan J, Furka I, Sapy P, Miko I, Peto K, Nemeth N Tags: Clin Hemorheol Microcirc Source Type: research

Gender Differences control the susceptibility to ER stress-induced acute kidney injury.
In this study we observed differences in the severity of kidney injury between male and female mice in response to tunicamycin, an ER stress agent. Tunicamycin-treated male mice showed a severe decline in kidney function, and extensive kidney damage of proximal tubules in the kidney outer cortex (S1 and S2 segments). Interestingly, female tunicamycin-treated mice didn't show a decline in kidney function, and their kidneys showed damage localized primarily to proximal tubules in the inner cortex (S3 segment). Protein markers of ER stress, glucose-regulated protein (BiP/GRP78) and X-box binding protein 1 (XBP1) were also mor...
Source: American Journal of Physiology. Renal Physiology - January 30, 2013 Category: Physiology Authors: Hodeify R, Megyesi J, Tarcsafalvi A, Mustafa HI, Hti Lar Seng NS, Price PM Tags: Am J Physiol Renal Physiol Source Type: research

AGING AND HEMOGLOBIN-INDUCED ACUTE KIDNEY INJURY.
Abstract No Abstract - Editorial Focus. PMID: 23364802 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - January 30, 2013 Category: Physiology Authors: Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research

ROLE OF GUANINE-NUCLEOTIDE EXCHANGE FACTOR EPAC IN RENAL PHYSIOLOGY AND PATHOPHYSIOLOGY.
Abstract Exchange proteins directly activated by cyclic AMP, Epac(s), were discovered more than a decade ago as new sensors for the second messenger cyclic AMP. The Epac family, including Epac1 and Epac2, are guanine nucleotide exchange factors for the Ras-like small GTPases Rap1 and Rap2, and they function independently of protein kinase A. Given the importance of cAMP in kidney homeostasis, several molecular and cellular studies using specific Epac agonists have analyzed the role and regulation of Epac proteins in renal physiology and pathophysiology. The specificity of the functions of Epac proteins may depend u...
Source: American Journal of Physiology. Renal Physiology - January 30, 2013 Category: Physiology Authors: Yang S, Xiao L, Li J, Liu F, Sun L, Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research

IMPAIRED PRESSURE NATRIURESIS RESULTING IN SALT SENSITIVE HYPERTENSION IS CAUSED BY TUBULOINTERSTITIAL IMMUNE CELL INFILTRATION IN THE KIDNEY.
Abstract Immune cell infiltration of the kidney is a constant feature in salt sensitive hypertension (SSHTN). We evaluated the relationship between the renal inflammation and pressure natriuresis in the model of salt-sensitive hypertension that results from transient oral administration of Nω-nitro-L-arginine methyl ester (L-NAME). Pressure natriuresis was determined in Sprague-Dawley rats that received 4 weeks of a high salt (4% NaCl) diet starting one week after stopping L-NAME that was administered alone (SSHTN group, n=17) or in association with mycophenolate mofetil (MMF group, n=15). The administration of MM...
Source: American Journal of Physiology. Renal Physiology - January 30, 2013 Category: Physiology Authors: Franco M, Tapia E, Bautista R, Pacheco U, Santamaría J, Quiroz Y, Johnson RJ, Rodriguez-Iturbe B Tags: Am J Physiol Renal Physiol Source Type: research

Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.
Abstract Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Recent studies have underscored a critical role for CCL2 (MCP-1)-mediated inflammation in the progression of chronic renal damage in RAS and other chronic renal diseases. In vitro studies have implicated p38 mitogen activated protein kinase (MAPK) as a critical intermediate for the production of CCL2. However, a potential role of p38 signaling in the development and progression of chronic renal disease in RAS has not been previously defined. We sought to test the hypothesis that inhibition of p38 MAPK ameliorates chronic renal ...
Source: American Journal of Physiology. Renal Physiology - January 30, 2013 Category: Physiology Authors: Wang D, Warner GM, Yin P, Knudsen BE, Cheng J, Butters K, Lien KR, Gray CE, Garovic VD, Lerman LO, Textor SC, Nath KA, Simari RD, Grande JP Tags: Am J Physiol Renal Physiol Source Type: research