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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Evolving roles of circadian rhythms in liver homeostasis and pathology.
Authors: Zhou D, Wang Y, Chen L, Jia L, Yuan J, Sun M, Zhang W, Wang P, Zuo J, Xu Z, Luan J Abstract Circadian clock in mammals is determined by a core oscillator in the suprachiasmatic nucleus (SCN) of the hypothalamus and synchronized peripheral clocks in other tissues. The coherent timing systems could sustain robust output of circadian rhythms in response to the entrainment controlled environmentally. Disparate approaches have discovered that clock genes and clock-controlled genes (CCGs) exist in nearly all mammalian cell types and are essential for establishing the mechanisms and complexity of internal time-ke...
Source: Oncotarget - February 9, 2016 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

PSA Testing Differs Among Primary Care Doctors, Urologists
Title: PSA Testing Differs Among Primary Care Doctors, UrologistsCategory: Health NewsCreated: 2/8/2016 12:00:00 AMLast Editorial Review: 2/9/2016 12:00:00 AM (Source: MedicineNet Mens Health General)
Source: MedicineNet Mens Health General - February 9, 2016 Category: Primary Care Source Type: news

Enhancer of zeste homolog 2 depletion arrests the proliferation of hepatoblastoma cells.
Authors: Wang Y, Xiao Y, Chen K, Chen S, Zhang M, Wu Z, Wu Y Abstract Hepatoblastoma is the most common type of malignant liver tumor in children. While outcomes have been greatly improved in the past decades, the treatment of advanced hepatoblastoma has remained challenging. Enhancer of zeste homologue 2 (EZH2), a member of the polycomb group regulators of gene activity, is amplified and overexpressed in a variety of cancers. However, the role of EZH2 in hepatoblastoma has remained to be fully elucidated. The purpose of the present study was to investigate the expression patterns of EZH2 in hepatoblastoma cells a...
Source: Molecular Medicine Reports - February 9, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Metformin inhibits growth of human non-small cell lung cancer cells via liver kinase B-1-independent activation of adenosine monophosphate-activated protein kinase.
Authors: Guo Q, Liu Z, Jiang L, Liu M, Ma J, Yang C, Han L, Nan K, Liang X Abstract Metformin, the most widely administered oral anti‑diabetic therapeutic agent, exerts its glucose-lowering effect predominantly via liver kinase B1 (LKB1)-dependent activation of adenosine monophosphate-activated protein kinase (AMPK). Accumulating evidence has demonstrated that metformin possesses potential antitumor effects. However, whether the antitumor effect of metformin is via the LKB1/AMPK signaling pathway remains to be determined. In the current study, the effects of metformin on proliferation, cell cycle progression, and...
Source: Molecular Medicine Reports - February 9, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Expression and function of microRNA‑27b in hepatocellular carcinoma.
Authors: He S, Zhang J, Lin J, Zhang C, Sun S Abstract It has been reported that microRNAs (miRs) have key roles in tumorigenesis via inhibition of their target genes. Dysregulation of miR‑27b has been detected in numerous types of human cancer, including hepatocellular carcinoma (HCC); however, the detailed role of miR‑27b in HCC has yet to be elucidated. Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to examine the mRNA and protein expression levels. Transwell assay and wound healing assay were used to determine cell invasion and migration. Luciferase report...
Source: Molecular Medicine Reports - February 9, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Polymyxin B hemoperfusion prevents acute kidney injury in sepsis model.
CONCLUSIONS: These findings suggest that PMX-DHP may protect against acute kidney injury not only by inhibiting the NF-κB signaling pathway but also by preventing renal tubular cell apoptosis. PMID: 26850185 [PubMed - in process] (Source: Cell Research)
Source: Cell Research - February 9, 2016 Category: Cytology Authors: Mitaka C, Masuda T, Kido K, Uchida T, Abe S, Miyasho T, Tomita M, Inada E Tags: J Surg Res Source Type: research

Transplantation of Kidneys From Circulatory Death DonorsTransplantation of Kidneys From Circulatory Death Donors
Could this approach for kidney transplantation using elderly circulatory death donors potentially expand the kidney donor pool? American Journal of Transplantation (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - February 9, 2016 Category: Transplant Surgery Tags: Transplantation Journal Article Source Type: news

ART influences HIV persistence in the female reproductive tract and cervicovaginal secretions
The recently completed HIV prevention trials network study 052 is a landmark collaboration demonstrating that HIV transmission in discordant couples can be dramatically reduced by treating the infected individual with antiretroviral therapy (ART). However, the cellular and virological events that occur in the female reproductive tract (FRT) during ART that result in such a drastic decrease in transmission were not studied and remain unknown. Here, we implemented an in vivo model of ART in BM/liver/thymus (BLT) humanized mice in order to better understand the ability of ART to prevent secondary HIV transmission. We demonstr...
Source: Journal of Clinical Investigation - February 9, 2016 Category: Biomedical Science Authors: Rikke Olesen, Michael D. Swanson, Martina Kovarova, Tomonori Nochi, Morgan Chateau, Jenna B. Honeycutt, Julie M. Long, Paul W. Denton, Michael G. Hudgens, Amy Richardson, Martin Tolstrup, Lars Østergaard, Angela Wahl, J. Victor Garcia Source Type: research

Beneficial effect of bilateral native nephrectomy as complete denervation on left ventricular mass and function in renal transplant recipients.
CONCLUSIONS    In a long-term follow-up of patients after kidney transplantation, the bilateral native nephrectomy before transplantation was associated with a lower LVMI and LAVI as well as a lower grade of LVDD. These patients had lower systolic BP and used fewer antihyper tensive drugs. PMID: 26842378 [PubMed - in process] (Source: Polskie Archiwum Medycyny Wewnetrznej)
Source: Polskie Archiwum Medycyny Wewnetrznej - February 9, 2016 Category: Internal Medicine Tags: Pol Arch Med Wewn Source Type: research

[French translation of "An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female pelvic floor dysfunction" published in Int Urogynecol J 2010;21(1):5-26].
CONCLUSIONS: The work conducted led to the development of a consensual terminology of female pelvic floor disorders. This document has been designed to provide substantial assistance in clinical practice and research. LEVEL OF EVIDENCE: 4. PMID: 26852300 [PubMed - as supplied by publisher] (Source: Progres en Urologie)
Source: Progres en Urologie - February 9, 2016 Category: Urology & Nephrology Tags: Prog Urol Source Type: research

How should we analyze and present mortality in our patients?: A multicentre GCDP experience.
CONCLUSIONS: Although each method may be correct in themselves and express different approaches, the final impression left on the reader is a number that under/overestimates mortality. The CR model better expresses the reality of PD, where the number of patients lost to follow-up (transplant, transfer to HD) it is 4 times more than deceased patients and only a quarter remain on PD at the end of follow up. PMID: 26851832 [PubMed - as supplied by publisher] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - February 9, 2016 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Recurrence of ANCA-associated vasculitis in a patient with kidney trasplant.
We describe the case of a male patient with extracapillary glomerulonephritis type III C-ANCA (+) who developed a recurrence in the renal allograft 8 years after transplantation. Intensive immunosupression with plasmapheresis controlled the disease. PMID: 26850517 [PubMed - as supplied by publisher] (Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia)
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - February 9, 2016 Category: Urology & Nephrology Tags: Nefrologia Source Type: research

Is adapted apd theoretically more efficient than conventional apd?
Conclusions: Due mainly to the increased fill volumes in 3 out of 5 dwells in aAPD, this modality caused minor increases in small solute clearances and marginal effects on UF and NaR. The computer simulations point to a need for accurate sodium determinations in aAPD, considering all the methodological problems and pitfalls relevant to determining dialysate Na+ concentrations and peritoneal sodium mass balance. PMID: 26847586 [PubMed - as supplied by publisher] (Source: Peritoneal Dialysis International)
Source: Peritoneal Dialysis International - February 9, 2016 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research

Older age, higher body mass index and inflammation increase the risk for new-onset diabetes and impaired glucose tolerance in patients on peritoneal dialysis.
Conclusions: Traditional and uremic-related risk factors, such as older age, higher BMI, and inflammation, contribute to new-onset diabetes and impaired glucose tolerance in PD patients. PMID: 26847585 [PubMed - as supplied by publisher] (Source: Peritoneal Dialysis International)
Source: Peritoneal Dialysis International - February 9, 2016 Category: Urology & Nephrology Tags: Perit Dial Int Source Type: research

St John's Wort safety alert as packs of herbal supplement are recalled over poisoning fears
Batches of St John's Wort tablets manufactured for Superdrug and Asda have been recalled due to high levels of a plant material that can cause liver damage, the UK's drug regulator said today. (Source: the Mail online | Health)
Source: the Mail online | Health - February 9, 2016 Category: Consumer Health News Source Type: news

Molecular impacts of Perfluorinated Chemicals (PFASs) in the liver and testis of male largemouth bass (Micropterus salmoides) in Minnesota Lakes
This study investigated whether fish with high body burden levels of PFASs in the Twin Cities Metro Areas showed any evidence of adverse effects at the level of the transcriptome. We hypothesized that fish with higher body burden levels of PFASs would exhibit molecular responses in the liver and testis that were suggestive of oxidative and general stress, as well as impaired reproduction. Concentrations of PFASs in largemouth bass varied significantly across the sampled lakes, with the lowest concentrations of PFASs found in fish from Steiger and Upper Prior Lakes and the highest concentrations found in fish from Calhoun a...
Source: Comparative Biochemistry and Physiology Part D: Genomics and Proteomics - February 9, 2016 Category: Genetics & Stem Cells Source Type: research

Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells
Publication date: Available online 9 February 2016 Source:Parasitology International Author(s): Sujittra Chaiyadet, Michael Smout, Thewarach Laha, Banchob Sripa, Alex Loukas, Javier Sotillo The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA, but the excretory/secretory products released by O. viverrini (OvES) represent the major interface between the parasite and its host, and their uptake by biliary epithelial cells has been sugge...
Source: Parasitology International - February 9, 2016 Category: Parasitology Source Type: research

The relationship between chronic obstructive pulmonary disease and transcatheter aortic valve implantation—A systematic review and meta‐analysis
Conclusion: COPD is common among patients undergoing TAVI, and COPD impacts both short‐ and long‐term survival. COPD patients, who had a lower BMI, shorter distance of 6MWT and CKD, were at higher risk for TAVI futility. © 2016 Wiley Periodicals, Inc. (Source: Catheterization and Cardiovascular Interventions)
Source: Catheterization and Cardiovascular Interventions - February 9, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Yan‐Biao Liao, Ze‐Xia He, Zhen‐Gang Zhao, Xin Wei, Zhi‐liang Zuo, Yi‐Jian Li, Tian‐Yuan Xiong, Yuan‐Ning Xu, Yuan Feng, Mao Chen Tags: Valvular and Structural Heart Diseases Source Type: research

Cell Phenotype Transitions in Renal Fibrosis
Abstract Kidney fibrosis continues to be a topic of enormous biomedical importance as the histologic manifestation of chronic kidney disease regardless of etiology. An active debate surrounds the fundamental issue of identity and ontogeny of the cells responsible for producing renal fibrosis, beginning with the hypothesis that epithelial cells undergo a phenotypic transition to a mesenchymal state (epithelial–mesenchymal transition) to populate the interstitium as myofibroblasts. The subsequent publication of a large body of experimental evidence supports the notion of phenotypic alteration on the part of renal ...
Source: Current Pathobiology Reports - February 9, 2016 Category: Laboratory Medicine Source Type: research

Potential in two types of collagen scaffolds for urological tissue engineering applications - Are there differences in growth behaviour of juvenile and adult vesical cells?
The aging society has a deep impact on patient care in urology. The number of patients in need of partial or whole bladder wall replacement is increasing simultaneously with the number of cancer incidents. Therefore, urological research requires a model of bladder wall replacement in adult and elderly people. Two types of porcine collagen I/III scaffolds were used in vitro for comparison of cell growth of two different pig breeds at different growth stages. Scaffolds were characterised with scanning electron and laser scanning microscopy. Urothelial and detrusor smooth muscle cells were isolated from 15 adult Go0...
Source: Journal of Biomaterials Applications - February 9, 2016 Category: Materials Science Authors: Leonhäuser, D., Vogt, M., Tolba, R., Grosse, J. Tags: Soft Tissues and Materials Source Type: research

Hemocompatibility evaluation for peptide fragments of human serum albumin cleaved by cyanogens bromide
In this study, three kinds of peptide fragments were prepared and identified by amino acid analysis, and the blood compatibility of the peptide fragments was investigated by measuring blood coagulation, platelet and complement activation and hemolysis activity. Results indicated that all the peptide fragments prepared were highly hemocompatible without causing any clot formation, red blood cell aggregation or immune response. In addition, data from the cytotoxicity assay using HeLa cells and Madin-Darby canine kidney cells suggested that these peptide fragments do not induce toxicity towards either cell lines at concentrat...
Source: Journal of Biomaterials Applications - February 9, 2016 Category: Materials Science Authors: Wu, X.-j., Tang, E. K., Xu, C.-q., Yuan, Z.-x. Tags: Soft Tissues and Materials Source Type: research

Diagnostic performance of multidetector computed tomography in the evaluation of esophageal varices
Conclusion MDCT is a fast, well tolerable, non-invasive procedure and accepted from most of the examined patients for evaluation and grading of EV, detection of other portosystemic collaterals and hepatobiliary pathologies. (Source: The Egyptian Journal of Radiology and Nuclear Medicine)
Source: The Egyptian Journal of Radiology and Nuclear Medicine - February 9, 2016 Category: Nuclear Medicine Source Type: research

Comparative study of CXC chemokines modulation in brown trout (Salmo trutta) following infection with a bacterial or viral pathogen
This study gives clues to the role of the novel CXC chemokines, in comparison to the other known CXC chemokines in salmonids. (Source: Molecular Immunology)
Source: Molecular Immunology - February 9, 2016 Category: Allergy & Immunology Source Type: research

Plasma level of metastasis‐associated lung adenocarcinoma transcript 1 is associated with liver damage and predicts development of hepatocellular carcinoma
In conclusion, the plasma MALAT1 level is associated with liver damage, and has clinical utility for predicting development of HCC. The aim of present study was to investigate the significance of plasma MALAT1 levels in HCC patients. Plasma MALAT1 levels were progressively and significantly higher in HCC patients than hepatic disease patients, and higher in hepatic disease patients than healthy controls. Plasma MALAT1 levels have clinical utility for predicting liver damage and development of HCC. (Source: Cancer Science)
Source: Cancer Science - February 9, 2016 Category: Cancer & Oncology Authors: Hirotaka Konishi, Daisuke Ichikawa, Yusuke Yamamoto, Tomohiro Arita, Katsutoshi Shoda, Hidekazu Hiramoto, Junichi Hamada, Hiroshi Itoh, Yuji Fujita, Shuhei Komatsu, Atsushi Shiozaki, Hisashi Ikoma, Toshiya Ochiai, Eigo Otsuji Tags: Original Article Source Type: research

PSA Testing Differs Among Primary Care Doctors, Urologists
Researchers examine falloff after change in prostate cancer screening recommendations (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - February 9, 2016 Category: Cancer & Oncology Source Type: news

β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases
This study aimed to investigate the value of established prognostic markers and WNT signaling components in liver metastases. Overall N = 34 breast cancer liver metastases (with matched primaries in 19/34 cases) were included in this retrospective study. Primaries and metastatic samples were analyzed for their expression of the estrogen (ER) and progesterone receptor, HER-2, Ki67, and various WNT signaling-components by immunohistochemistry. Furthermore, β-catenin-dependent and -independent WNT scores were generated and analyzed for their prognostic value. Additionally, the influence of the alternative WNT receptor ROR ...
Source: Clinical and Experimental Metastasis - February 9, 2016 Category: Cancer & Oncology Source Type: research

Can we obtain planning goals for conformal techniques in neoadjuvant and adjuvant radiochemotherapy for gastric cancer patients?
Conclusions Comparison of 3D conformal radiotherapy techniques in gastric cancer patients indicates that none of the plans can fulfil simultaneously all of the criteria of the tolerance dose in the organs at risk. The implementation of the multi-field technique can minimise the toxicity of treatment and improve dose distribution homogeneity in the target volume with additional protection of organs at risk (OaRs). (Source: Reports of Practical Oncology and Radiotherapy)
Source: Reports of Practical Oncology and Radiotherapy - February 9, 2016 Category: Cancer & Oncology Source Type: research

Blood Pressure Control Provides Less Cardiovascular Protection in Adults With Than Without Apparent Treatment‐Resistant Hypertension
Hypertension control may offer less protection from incident cardiovascular disease (CVDi) in adults with than without apparent treatment‐resistant hypertension (aTRH), ie, blood pressure uncontrolled while taking three or more antihypertensive medications or controlled to <140/<90 mm Hg while taking four or more antihypertensive medications. Electronic health data were matched to health claims for 2006–2012. Patients with CVDi in 2006–2007 or with untreated hypertension were excluded, leaving 118,356 treated hypertensives, including 40,690 with aTRH, and 460,599 observation years. Blood pressure and medication...
Source: The Journal of Clinical Hypertension - February 9, 2016 Category: Cardiology Authors: Brent M. Egan, Bo Kai, C. Shaun Wagner, Joseph H. Henderson, Archie H. Chandler, Angelo Sinopoli Tags: Original Paper Source Type: research

Branched‐chain amino acid‐enriched nutrient increases blood platelet count in patients after endoscopic injection sclerotherapy
ConclusionEIS induced protein‐energy malnutrition, however skeletal muscle volume maintained by taking BCAA. Administration of BCAA had some effect to keep the nutritional state, and might improve the platelet count. Taking a greater amount of nutrient and shorter dietary restriction period or hospitalization was desirable. (Source: Hepatology Research)
Source: Hepatology Research - February 9, 2016 Category: Internal Medicine Authors: Yoshihiro Furuichi, Yasuharu Imai, Yuki Miyata, Katsutoshi Sugimoto, Takatomo Sano, Junichi Taira, Mayumi Kojima, Yoshiyuki Kobayashi, Ikuo Nakamura, Fuminori Moriyasu Tags: Original Article Source Type: research

Role of neutrophil to lymphocyte ratio in the prognosis of male patients with hepatocellular carcinoma undergoing liver transplantation
(Source: Hepatology Research)
Source: Hepatology Research - February 9, 2016 Category: Internal Medicine Authors: Yi‐Jing Cai Tags: Letter to the Editor Source Type: research

Oral Microbiome: Contributions to Local and Systemic Infections
Abstract The recent revolution of diagnostic methods emphasizing non-culture techniques has redefined the oral microbiota, its “Dual Citizenship”, recognizing oral flora inhabitants of eight dispersed locations are colonized by over 700 species, equal in bacteria (16S) and fungi (18S). Either prefers the attached biofilm phenotype, biotic or abiotic surfaces, its extra polymeric substance (EPS) protected environment promoting horizontal gene transfer (HGT), and gene amplified resistance. The biofilm growth pattern mimics that of solid tumors and a four-stage lifestyle (I–IV) catalyzing the term biotumor, emp...
Source: Current Oral Health Reports - February 9, 2016 Category: Dentistry Source Type: research

Anti-diabetic effect of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) fruit acetone fraction in a type 2 diabetes model of rats
Conclusion The results of our study suggest that XAAF treatment showed excellent anti-diabetic effects in a T2D model of rats. Graphical abstract (Source: Journal of Ethnopharmacology)
Source: Journal of Ethnopharmacology - February 9, 2016 Category: Drugs & Pharmacology Source Type: research

Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats
In conclusion, these results suggest that blood glucose fluctuation accelerated renal injury is due, at least in part to its oxidative stress promoting and inhibiting the AKT signaling pathway in diabetic rats. (Source: Endocrine)
Source: Endocrine - February 9, 2016 Category: Endocrinology Source Type: research

Intestinal Microbiota in Liver Disease
The intestinal microbiota have emerged as a topic of intense interest in gastroenterology and hepatology. The liver is on the front line as the first filter of nutrients, toxins and bacterial metabolites from the intestines and we are becoming increasingly aware of interactions among the gut, liver and immune system as important mediators of liver health and disease. Manipulating the microbiota with therapeutic intent is a rapidly expanding field. In this review, we will describe what is known about the contribution of intestinal microbiota to liver homeostasis; the role of dysbiosis in the pathogenesis of liver disease in...
Source: Best Practice and Research. Clinical Gastroenterology - February 9, 2016 Category: Gastroenterology Authors: Tanvir R. Haque, A.Sidney Barritt Source Type: research

Genetic Factors That Affect Risk of Alcoholic and Non-Alcoholic Fatty Liver Disease
Genome-wide association studies (GWAS) and candidate gene studies have informed our understanding of factors contributing to the well-recognized inter-individual variation in progression and outcomes of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD). We discuss the mounting evidence for shared modifiers and common pathophysiological processes that contribute to development of both diseases. We discuss the functions of proteins encoded by risk variants of genes including PNPLA3 and TM6SF2, as well as epigenetic factors that contribute to the pathogenesis of ALD and NAFLD. (Source: Gastroenterology)
Source: Gastroenterology - February 9, 2016 Category: Gastroenterology Authors: Quentin M. Anstee, Devanshi Seth, Christopher P. Day Source Type: research

Endoscopic management with multiple plastic stents of anastomotic biliary stricture following liver transplantation: long-term results
Conclusions: At long-term follow-up, endoscopic treatment with multiple plastic stents of ABS following OLT appeared to be effective in most patients. Stricture recurrence is rare and can be successfully treated again endoscopically.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: Endoscopy)
Source: Endoscopy - February 9, 2016 Category: Gastroenterology Authors: Tringali, AndreaBarbaro, FedericoPizzicannella, MargheritaBoškoski, IvoFamiliari, PietroPerri, VincenzoGigante, GiovanniOnder, GrazianoHassan, CesareLionetti, RaffaellaEttorre, Giuseppe MariaCostamagna, Guido Tags: Original article Source Type: research

Doing More Than Caring About Quality
This article provides an opinion on principles that may fundamentally improve the quality of renal disease care in the future and represents themes that can enhance quality, safety, and efficiency in the health care delivery system. It is believed that quality measured from a patient centric perspective will shift the treatment for these chronic disorders to better meet each patient's needs and goals, while evolving an enhanced delivery system for the care of all ESRD patients. (Source: Seminars In Dialysis)
Source: Seminars In Dialysis - February 9, 2016 Category: Hematology Authors: Franklin W. Maddux Tags: Patient ‐Centered Quality of Care in Dialysis Source Type: research

Evaluation of clinicopathologic characteristics and the BRAF V600E mutation in Erdheim-Chester disease among Chinese adults
Abstract Erdheim-Chester disease (ECD) is a rare form of histiocytosis with a broad, non-specific clinical spectrum. Here, we retrospectively evaluated the clinical and pathologic characteristics, presence of the BRAF V600E mutation, treatment options, and outcomes of Chinese patients diagnosed with ECD at our center. Patients diagnosed with ECD between January 2010 and April 2015 at Peking Union Medical College Hospital were included for study. We evaluated baseline characteristics, reviewed histological material, and tested for the presence of the BRAF V600E mutation using immunohistochemistry and polymerase cha...
Source: Annals of Hematology - February 9, 2016 Category: Hematology Source Type: research

Hypersplenism in liver disease and SLE revisited: current evidence supports an active rather than passive process
Discussion Cytopenias and splenomegaly in both liver disease and systemic lupus erythematosus (SLE) poorly correlate with portal hypertension, and likely reflect an active process allocating stem cell resources in response to injury. Organ injury is repaired partly by bone-marrow-derived stem cells. Signaling would thus be needed to allocate resources between repair and routine marrow activities, hematologic and bone production. Granulocyte-colony stimulating factor (G-CSF) may play a central role: mobilizing stem cells, increasing spleen size and downregulating bone production. Serum G-CSF rises with liver inju...
Source: BMC Hematology - February 9, 2016 Category: Hematology Source Type: research

Does SVR Prevent Transplant in HCV?
Abstract Sustained virologic response significantly reduces the risk of cirrhosis, hepatic decompensation, hepatocellular carcinoma, mortality, and the need for liver transplantation in patients with chronic hepatitis C. Thus, broad treatment prior to hepatic decompensation will likely prevent the need for transplant in many individuals. With emerging data on the use of direct acting antiviral regimens in patients with decompensated cirrhosis, it is now also feasible to successfully treat many of these high-risk patients, leading to improvement in liver function as measured by MELD score and Childs-Turcotte-Pugh c...
Source: Current Hepatitis Reports - February 9, 2016 Category: Infectious Diseases Source Type: research

The role of genomic islands in Escherichia coli K1 interactions with intestinal and kidney epithelial cells
In this study, the role of various genomic islands in Escherichia coli K1 interactions with intestinal epithelial cells (Caco-2) and kidney epithelial cells (MA104) was determined. Using association assays, invasion assays, and intracellular survival assays, the findings revealed that the genomic island deletion mutants of RS218 related to P fimbriae, S fimbriae, F17-like fimbriae, non-fimbrial adhesins, Hek and hemagglutinin, protein secretion system (T1SS for hemolysin; T2SS; T5SS for antigen 43), Iro system and hmu system), invasins (CNF1, IbeA), toxins (α-hemolysin), K1 capsule biosynthesis, metabolism (D-serine catab...
Source: Microbial Pathogenesis - February 9, 2016 Category: Infectious Diseases Source Type: research

High incidence of tuberculosis in patients treated for hepatitis C chronic infection
Publication date: Available online 9 February 2016 Source:The Brazilian Journal of Infectious Diseases Author(s): Silvia Naomi de Oliveira Uehara, Christini Takemi Emori, Renata Mello Perez, Maria Cassia Jacintho Mendes-Correa, Adalgisa de Souza Paiva Ferreira, Ana Cristina de Castro Amaral Feldner, Antonio Eduardo Benedito Silva, Roberto José Carvalho Filho, Ivonete Sandra de Souza e Silva, Maria Lucia Cardoso Gomes Ferraz Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coin...
Source: The Brazilian Journal of Infectious Diseases - February 9, 2016 Category: Infectious Diseases Source Type: research

Liver function in Huntington's disease assessed by blood biochemical analyses in a clinical setting
Huntington's disease (HD) is a dominantly inherited, progressive neurological disorder caused by a CAG repeat elongation in the huntingtin gene. In addition to motor-, psychiatric- and cognitive dysfunction, peripheral disease manifestations in the form of metabolic changes and cellular dysfunction are seen. Blood levels of a wide range of hormones, metabolites and proteins have been analyzed in HD patients, identifying several changes associated with the disease. However, a comprehensive panel of liver function tests (LFT) has not been performed. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - February 9, 2016 Category: Neurology Authors: Signe Marie Borch Nielsen, Tua Vinther-Jensen, Jørgen E. Nielsen, Anne Nørremølle, Lis Hasholt, Lena E. Hjermind, Knud Josefsenc Source Type: research

Chapter 11: Metabolic Syndrome, Diet and Exercise
Polycystic ovary syndrome (PCOS) is associated with a range of metabolic complications including insulin resistance, obesity, dyslipidaemia, hypertension, obstructive sleep apnoea and non-alcoholic fatty liver disease. These compound risks result in a high prevalence of metabolic syndrome and possibly increased cardiovascular disease. As the cardiometabolic risk of PCOS is shared amongst the different diagnostic systems, all women with PCOS should undergo metabolic surveillance though the precise approach differs between guidelines. (Source: Best Practice and Research. Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research. Clinical Obstetrics and Gynaecology - February 9, 2016 Category: OBGYN Authors: Sunita MC. De Sousa, Robert J. Norman AO Source Type: research

New and emerging renal tumour entities
In this review, we discuss new and emerging renal cell carcinoma (RCC) entities, including anaplastic lymphoma kinase (ALK) RCC, oncocytic variant of chromophobe RCC, atrophic kidney-like renal tumour, biphasic alveolosquamoid RCC, tubulocystic RCC, thyroid-like follicular carcinoma of the kidney, succinate dehydrogenase-deficient RCC, Birt–Hogg–Dubé syndrome-associated renal tumour, hereditary leiomyomatosis/renal cell carcinoma associated RCC, tuberous sclerosis-associated RCC, PTEN hamartoma tumour syndrome, clear cell papillary RCC, acquired cystic disease-associated RCC, Xp11.2 RCC, t(6;11) RCC and renal hemangio...
Source: Diagnostic Histopathology - February 9, 2016 Category: Pathology Authors: Naoto Kuroda, Ondřej Hess, Ming Zhou Tags: Pathology of kidney tumours Source Type: research

Approach to Haemangiomatosis Causing Congestive Heart Failure
ConclusionOur approach incorporates heart failure medications, dietary support and propranolol as first‐line treatment, while corticosteroids, vincristine, percutaneous intervention and surgery are reserved for refractory cases.This article is protected by copyright. All rights reserved. (Source: Acta Paediatrica)
Source: Acta Paediatrica - February 9, 2016 Category: Pediatrics Authors: Roie Tal, Moshe Dotan, Avraham Lorber Tags: Review Article Source Type: research

The effect of enriched chicory inulin on liver enzymes, calcium homeostasis and hematological parameters in patients with type 2 diabetes mellitus: A randomized placebo-controlled trial
Type 2 diabetes mellitus (T2DM) is one of the serious costly diseases that affects approximately 347 million people worldwide; it has been estimated that the global prevalence of T2DM would reach to 366 million people in 2030 [1]. T2DM is associated with numerous co-morbidities including cardiovascular events, hypertension, renal and ocular disturbances and impaired mental status which finally leads to poor life expectancy among these patients [2]. (Source: Primary Care Diabetes)
Source: Primary Care Diabetes - February 9, 2016 Category: Primary Care Authors: Mahdieh Abbasalizad Farhangi, Ahmad Zare Javid, Parvin Dehghan Source Type: research

Impact of stress on metabolism and energy balance
Publication date: Available online 7 February 2016 Source:Current Opinion in Behavioral Sciences Author(s): Cristina Rabasa, Suzanne L Dickson The stress response mobilizes the body's energy stores in order to respond to a threatening situation. A striking observation is the diversity of metabolic changes that can occur in response to stress. On one hand acute intense stress is commonly associated with feeding suppression and reduced body weight gain. The activation of the hypothalamic–pituitary–adrenal axis and the release of corticotropin-releasing hormone (CRH) might partially explain the anorexigenic effects of...
Source: Current Opinion in Behavioral Sciences - February 9, 2016 Category: Psychiatry & Psychology Source Type: research