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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice
The proximal renal epithelia express three different Na-dependent inorganic phosphate (Pi) cotransporters: NaPi-IIa/SLC34A1, NaPi-IIc/SLC34A3, and PiT2/SLC20A2. Constitutive mouse knockout models of NaPi-IIa and NaPi-IIc suggested that NaPi-IIa mediates the bulk of renal reabsorption of Pi whereas the contribution of NaPi-IIc to this process is minor and probably restricted to young mice. However, many reports indicate that mutations of NaPi-IIc in humans lead to hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Here, we report the generation of a kidney-specific and inducible NaPi-IIc-deficient mouse model b...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Myakala, K., Motta, S., Murer, H., Wagner, C. A., Koesters, R., Biber, J., Hernando, N. Tags: ARTICLES Source Type: research

A distributed two-pore model: theoretical implications and practical application to the glomerular sieving of Ficoll
In the present study, an extended two-pore theory is presented where the porous pathways are continuously distributed according to small- and large-pore mean radii and SDs. Experimental glomerular sieving data for Ficoll were analyzed using the model. In addition, several theoretical findings are presented along with analytic solutions to many of the equations used in distributed pore modeling. The results of the data analysis revealed a small-pore population in the glomerular capillary wall with a mean radius of 36.6 Å having a wide arithmetic SD of ~5 Å and a large-pore radius of 98.6 Å with an even wid...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Oberg, C. M., Rippe, B. Tags: ARTICLES Source Type: research

ANG-(3-4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA
The physiological roles of ANG-(3–4) (Val-Tyr), a potent ANG II-derived peptide, remain largely unknown. The present study 1)investigates whether ANG-(3–4) modulates ouabain-resistant Na+-ATPase resident in proximal tubule cells and 2) verifies whether its possible action on pumping activity, considered the fine tuner of Na+ reabsorption in this nephron segment, depends on blood pressure. ANG-(3–4) inhibited Na+-ATPase activity in membranes of spontaneously hypertensive rats (SHR) at nanomolar concentrations, with no effect in Wistar-Kyoto (WKY) rats or on Na+-K+-ATPase. PD123319 (10–7 M) and PKA(5&...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Dias, J., Ferrao, F. M., Axelband, F., Carmona, A. K., Lara, L. S., Vieyra, A. Tags: ARTICLES Source Type: research

Iodinated contrast media cause direct tubular cell damage, leading to oxidative stress, low nitric oxide, and impairment of tubuloglomerular feedback
Iodinated contrast media (CM) have adverse effects that may result in contrast-induced acute kidney injury. Oxidative stress is believed to play a role in CM-induced kidney injury. We test the hypothesis that oxidative stress and reduced nitric oxide in tubules are consequences of CM-induced direct cell damage and that increased local oxidative stress may increase tubuloglomerular feedback. Rat thick ascending limbs (TAL) were isolated and perfused. Superoxide and nitric oxide were quantified using fluorescence techniques. Cell death rate was estimated using propidium iodide and trypan blue. The function of macula densa an...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Liu, Z. Z., Schmerbach, K., Lu, Y., Perlewitz, A., Nikitina, T., Cantow, K., Seeliger, E., Persson, P. B., Patzak, A., Liu, R., Sendeski, M. M. Tags: ARTICLES Source Type: research

Remote conditioning or erythropoietin before surgery primes kidneys to clear ischemia-reperfusion-damaged cells: a renoprotective mechanism?
Acute kidney injury is common, serious with no specific treatment. Ischemia-reperfusion is a common cause of acute kidney injury (AKI). Clinical trials suggest that preoperative erythropoietin (EPO) or remote ischemic preconditioning may have a renoprotective effect. Using a porcine model of warm ischemia-reperfusion-induced AKI (40-min bilateral cross-clamping of renal arteries, 48-h reperfusion), we examined the renoprotective efficacy of EPO (1,000 iu/kg iv.) or remote ischemic preconditioning (3 cycles, 5-min inflation/deflation to 200 mmHg of a hindlimb sphygmomanometer cuff). Ischemia-reperfusion induced significant ...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Gardner, D. S., Welham, S. J. M., Dunford, L. J., McCulloch, T. A., Hodi, Z., Sleeman, P., O'Sullivan, S., Devonald, M. A. J. Tags: ARTICLES Source Type: research

Kidney injury molecule-1 expression in IgA nephropathy and its correlation with hypoxia and tubulointerstitial inflammation
Tubulointerstitial injury plays an important role in the development and progression of chronic kidney disease (CKD). Kidney injury molecule (KIM)-1 is induced in damaged proximal tubules in both acute renal injury and CKD. However, the dynamics of KIM-1 in CKD and effects of KIM-1 expression on disease progression are unknown. Here, we aimed to determine the associations between tubular KIM-1 expression levels, renal function, and inflammation in CKD. The relationships between levels of KIM-1 and clinicopathological parameters were analyzed in patients with progressive and nonprogressive IgA nephropathy. KIM-1 expression ...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Lin, Q., Chen, Y., Lv, J., Zhang, H., Tang, J., Gunaratnam, L., Li, X., Yang, L. Tags: ARTICLES Source Type: research

Albumin-bound fatty acids but not albumin itself alter redox balance in tubular epithelial cells and induce a peroxide-mediated redox-sensitive apoptosis
Albuminuria is associated with metabolic syndrome and diabetes. It correlates with the progression of chronic kidney disease, particularly with tubular atrophy. The fatty acid load on albumin significantly increases in obesity, presenting a proinflammatory environment to the proximal tubules. However, little is known about changes in the redox milieu during fatty acid overload and how redox-sensitive mechanisms mediate cell death. Here, we show that albumin with fatty acid impurities or conjugated with palmitate but not albumin itself compromised mitochondrial and cell viability, membrane potential and respiration. Fatty a...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Ruggiero, C., Elks, C. M., Kruger, C., Cleland, E., Addison, K., Noland, R. C., Stadler, K. Tags: ARTICLES Source Type: research

Renal tubular Notch signaling triggers a prosenescent state after acute kidney injury
In conclusion, our data suggest that sustained epithelial Notch activation after IR might contribute to the inferior outcome of old kidneys after injury. Sustained epithelial activation of Notch is associated with a prosenescent phenotype and maladaptive repair. (Source: AJP: Renal Physiology)
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Sorensen-Zender, I., Rong, S., Susnik, N., Zender, S., Pennekamp, P., Melk, A., Haller, H., Schmitt, R. Tags: ARTICLES Source Type: research

ER stress triggers MCP-1 expression through SET7/9-induced histone methylation in the kidneys of db/db mice
Epigenetics plays a key role in the pathogenesis of diabetic nephropathy (DN), although the precise regulatory mechanism is still unclear. Here, we examined the role of endoplasmic reticulum (ER) stress in histone H3 lysine 4 (H3K4) methyltransferase SET7/9-induced monocyte chemoattractant protein-1 (MCP-1) expression in the kidneys of db/db mice. Our results indicate that the expression of MCP-1 significantly increased in the kidneys of db/db mice in a time-dependent manner. An increased chromatin mark associated with an active gene (H3K4me1) at MCP-1 promoters accompanied this change in expression. The expression of SET7...
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Authors: Chen, J., Guo, Y., Zeng, W., Huang, L., Pang, Q., Nie, L., Mu, J., Yuan, F., Feng, B. Tags: ARTICLES Source Type: research

2014 Robert W. Berliner Award for Excellence in Renal Physiology
(Source: AJP: Renal Physiology)
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Tags: ANNOUNCEMENTS Source Type: research

2014 Carl W. Gottschalk Distinguished Lecturer of the American Physiological Society Renal Section
(Source: AJP: Renal Physiology)
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Tags: ANNOUNCEMENTS Source Type: research

2014 Young Investigator Award of the American Physiological Society Renal Section
(Source: AJP: Renal Physiology)
Source: AJP: Renal Physiology - April 15, 2014 Category: Urology & Nephrology Tags: ANNOUNCEMENTS Source Type: research

Fialuridine Induces Acute Liver Failure in Chimeric TK-NOG Mice: A Model for Detecting Hepatic Drug Toxicity Prior to Human Testing
Conclusions FIAU-induced liver toxicity could be readily detected using chimeric TK-NOG mice with humanized livers, even when the mice were treated with a FIAU dose that was only 10-fold above the dose used in human participants. The clinical features, laboratory abnormalities, liver histology, and ultra-structural changes observed in FIAU-treated chimeric mice mirrored those of FIAU-treated human participants. The use of chimeric mice in preclinical toxicology studies could improve the safety of candidate medications selected for testing in human participants.Please see later in the article for the Editors' Summary (Source: PLoS Medicine)
Source: PLoS Medicine - April 15, 2014 Category: Internal Medicine Authors: Dan Xu et al. Source Type: research

CD133 and kidney repair [Biological Sciences]
Kusaba et al. provide additional evidence using genetic lineage analysis that epithelial cell dedifferentiation is responsible for repair of proximal tubules after injury in mouse (1). These data challenge the hypothesis of the implication of scattered stem cells in such a process or highlight a potential distinction between rodent and... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 15, 2014 Category: Science Authors: Corbeil, D., Fargeas, C. A., Jaszai, J. Tags: Letters Source Type: research

Dedifferentiation and multipotency [Biological Sciences]
We thank Corbeil et al. for raising important points (1) regarding our recent article (2) describing the role of epithelial dedifferentiation in kidney repair. We agree that the forward primer we used to detect CD133 mRNA is in fact not directed against the CD133 transcript. This error resulted from the... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 15, 2014 Category: Science Authors: Kusaba, T., Humphreys, B. D. Tags: Letters Source Type: research

Correction for Kusaba et al., Differentiated kidney epithelial cells repair injured proximal tubule [Correction]
MEDICAL SCIENCES Correction for “Differentiated kidney epithelial cells repair injured proximal tubule,” by Tetsuro Kusaba, Matthew Lalli, Rafael Kramann, Akio Kobayashi, and Benjamin D. Humphreys, which appeared in issue 4, January 28, 2014, of Proc Natl Acad Sci USA (111:1527–1532; first published October 14, 2013; 10.1073/pnas.1310653110). The authors note that... (Source: Proceedings of the National Academy of Sciences)
Source: Proceedings of the National Academy of Sciences - April 15, 2014 Category: Science Tags: Corrections Source Type: research

Brugada Syndrome Disease Phenotype Explained in Apparently Benign Sodium Channel Mutations [Original Articles]
Conclusions— Taken together, we have shown how apparently benign SCN5A BrS mutations can lead to the ECG abnormalities seen in patients with BrS through an induced defect that is only present when the mutations are coexpressed with WT channels. Our work has implications for risk management and stratification for some SCN5A-implicated BrS patients. (Source: Circulation: Cardiovascular Genetics)
Source: Circulation: Cardiovascular Genetics - April 15, 2014 Category: Cardiology Authors: Hoshi, M., Du, X. X., Shinlapawittayatorn, K., Liu, H., Chai, S., Wan, X., Ficker, E., Deschenes, I. Tags: Clinical genetics, Arrythmias-basic studies, Ion channels/membrane transport, Arrhythmias, clinical electrophysiology, drugs Original Articles Source Type: research

Risk of Acute Kidney Injury After Percutaneous Coronary Interventions Using Radial Versus Femoral Vascular Access: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium [Coronary Interventions]
Conclusions— The risk of AKI was significantly lower after TRI compared with TFI. This finding needs to be evaluated in randomized controlled trials. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - April 15, 2014 Category: Cardiology Authors: Kooiman, J., Seth, M., Dixon, S., Wohns, D., LaLonde, T., Rao, S. V., Gurm, H. S. Tags: Imaging, Arterial thrombosis, Coronary imaging: angiography/ultrasound/Doppler/CC, Epidemiology, Coronary circulation Coronary Interventions Source Type: research

Remote Ischemic Postconditioning During Percutaneous Coronary Interventions: Remote Ischemic Postconditioning-Percutaneous Coronary Intervention Randomized Trial [Myocardial Infarction]
Conclusions— RIPost during PCI did not reduce the incidence of periprocedural myocardial injury. Similar effect was obtained when remote ischemia was induced to the upper or lower limb. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00970827. (Source: Circulation: Cardiovascular Interventions)
Source: Circulation: Cardiovascular Interventions - April 15, 2014 Category: Cardiology Authors: Lavi, S., D'Alfonso, S., Diamantouros, P., Camuglia, A., Garg, P., Teefy, P., Jablonsky, G., Sridhar, K., Lavi, R. Tags: Coronary circulation Myocardial Infarction Source Type: research

Intracarotid hypertonic sodium chloride differentially modulates sympathetic nerve activity to the heart and kidney
Hypertonic NaCl infused into the carotid arteries increases mean arterial pressure (MAP) and changes sympathetic nerve activity (SNA) via cerebral mechanisms. We hypothesized that elevated sodium levels in the blood supply to the brain would induce differential responses in renal and cardiac SNA via sensors located outside the blood-brain barrier. To investigate this hypothesis, we measured renal and cardiac SNA simultaneously in conscious sheep during intracarotid infusions of NaCl (1.2 M), sorbitol (2.4 M), or urea (2.4 M) at 1 ml/min for 4 min into each carotid. Intracarotid NaCl significantly increased MAP (91 ±...
Source: AJP: Regulatory, Integrative and Comparative Physiology - April 15, 2014 Category: Physiology Authors: Frithiof, R., Xing, T., McKinley, M. J., May, C. N., Ramchandra, R. Tags: Fluid and Electrolyte Homeostasis Source Type: research

Selective inhibition of angiotensin receptor signaling through Erk1/2 pathway by a novel peptide
A seven-amino acid peptide (PEP7) is encoded within a short open reading frame within exon 2 (E2) in the 5'-leader sequence (5'LS) upstream of the rat ANG 1a-receptor (rAT1aR) mRNA. A chemically synthesized PEP7 markedly inhibited ANG II-induced Erk1/2 activation in cell culture by 62% compared with a scrambled PEP7 (sPEP7) [pErk1/2/Erk1/2 (AU): ANG II, 1.000 ± 0.0, ANG II+PEP7, 0.3812 ± 0.086, ANG II+sPEP7, 1.069 ± 0.18; n = 3]. Under these same conditions, PEP7 had no effect on ANG II-stimulated inositol-trisphosphate production. PEP7 also had no effect on epidermal growth factor- and phorbol methyl ...
Source: AJP: Regulatory, Integrative and Comparative Physiology - April 15, 2014 Category: Physiology Authors: Liu, J., Yosten, G. L. C., Ji, H., Zhang, D., Zheng, W., Speth, R. C., Samson, W. K., Sandberg, K. Tags: Fluid and Electrolyte Homeostasis Source Type: research

Dynamics of male pelvic floor muscle contraction observed with transperineal ultrasound imaging differ between voluntary and evoked coughs
Coughing provokes stress urinary incontinence, and voluntary coughs are employed clinically to assess pelvic floor dysfunction. Understanding urethral dynamics during coughing in men is limited, and it is unclear whether voluntary coughs are an appropriate surrogate for spontaneous coughs. We aimed to investigate the dynamics of urethral motion in continent men during voluntary and evoked coughs. Thirteen men (28–42 years) with no history of urological disorders volunteered to participate. Transperineal ultrasound (US) images were recorded and synchronized with measures of intraabdominal pressure (IAP), airflow, and ...
Source: Journal of Applied Physiology - April 15, 2014 Category: Physiology Authors: Stafford, R. E., Mazzone, S., Ashton-Miller, J. A., Constantinou, C., Hodges, P. W. Tags: ARTICLES Source Type: research

BRAF mutation predicts for poor outcomes after metastasectomy in patients with metastatic colorectal cancer
CONCLUSIONSBRAF‐mutant mCRC is associated with worse clinical outcome. Patients with BRAF‐mutant tumors more commonly develop peritoneal metastases, less frequently present with disease limited to the liver, and have shorter survival after metastasectomy compared with patients with BRAF wild‐type tumors. Cancer 2014. © 2014 American Cancer Society. (Source: Cancer)
Source: Cancer - April 15, 2014 Category: Cancer & Oncology Authors: Rona Yaeger, Andrea Cercek, Joanne F. Chou, Brooke E. Sylvester, Nancy E. Kemeny, Jaclyn F. Hechtman, Marc Ladanyi, Neal Rosen, Martin R. Weiser, Marinela Capanu, David B. Solit, Michael I. D'Angelica, Efsevia Vakiani, Leonard B. Saltz Tags: Original Article Source Type: research

Acute renal failure associated with the new BRAF inhibitor vemurafenib: A case series of 8 patients
CONCLUSIONSFurther studies are needed to investigate the effects of vemurafenib on the kidneys. Meanwhile, renal function should be closely monitored in treated patients for early detection of any renal dysfunction occurrence. Cancer 2014. © 2014 American Cancer Society. (Source: Cancer)
Source: Cancer - April 15, 2014 Category: Cancer & Oncology Authors: Vincent Launay‐Vacher, Sarah Zimner‐Rapuch, Nicolas Poulalhon, Thibault Fraisse, Valérie Garrigue, Morgane Gosselin, Sabine Amet, Nicolas Janus, Gilbert Deray Tags: Original Article Source Type: research

Diagnostic challenge of large congenital liver cyst in the newborn
Abstract Liver cysts in the newborn often pose significant diagnostic challenges. Described herein is a case of large congenital liver cyst that was difficult to diagnose both antenatally and postnatally and which was later diagnosed as Caroli disease. (Source: Pediatrics International)
Source: Pediatrics International - April 15, 2014 Category: Pediatrics Authors: Sreekanth Viswanathan, Deepak Kumar Tags: Patient Report Source Type: research

Early effect of dutasteride added to alpha‐1 blocker therapy for patients with lower urinary tract symptoms associated with benign prostatic hyperplasia
ConclusionThis is the first prospective clinical study to show the early beneficial effects of 5‐alpha‐reductase inhibitors for lower urinary tract symptom‐associated benign prostatic hyperplasia. Patients with severe symptoms were found to be responsive to dutasteride. The influence of the placebo effect was not denied. Further study is necessary. (Source: International Journal of Urology)
Source: International Journal of Urology - April 15, 2014 Category: Urology & Nephrology Authors: Kazuhiro Araki, Yukio Naya, Masahiko Inahara, Fumio Suzuki, Syo Ota, Hirokatsu Tsuji, Kazuo Mikami, Mitsuru Yanagisawa, Yusuke Awa, Hiroyoshi Suzuki Tags: Original Article Source Type: research

Estimating age and ethnic variation in the histological prevalence of prostate cancer to inform the impact of screening policies
ConclusionsThe present study provides an updated and improved analysis of the histological prevalence of prostate cancer. The results confirm ethnicity as a potential predictor of prevalence, but highlight the need for further research in the area. The findings are valuable for understanding the epidemiology and natural history of prostate cancer across ethnicities, and increasing the body of evidence aimed at estimating benefits and risks associated with prostate cancer screening programs. (Source: International Journal of Urology)
Source: International Journal of Urology - April 15, 2014 Category: Urology & Nephrology Authors: Jose Leal, Freddie Hamdy, Jane Wolstenholme Tags: Original Article Source Type: research

Obstructive Sleep Apnea and Risk of Osteoporosis: A Population-Based Cohort Study in Taiwan.
Conclusion: People diagnosed with OSA are at increased risk for subsequent osteoporosis. PMID: 24735427 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 15, 2014 Category: Endocrinology Authors: Chen YL, Weng SF, Shen YC, Chou CW, Yang CY, Wang JJ, Tien KJ Tags: J Clin Endocrinol Metab Source Type: research

Thyroid status and renal function in older persons in the general population.
Conclusions: Although low thyroid function was associated with lower renal function at age 85 years, an association between a low thyroid function and change in renal function over time was absent. Our findings question the causal relevance of the thyroid status for the deterioration of renal function in the oldest old. PMID: 24735423 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 15, 2014 Category: Endocrinology Authors: Meuwese CL, Gussekloo J, de Craen AJ, Dekker FW, den Elzen WP Tags: J Clin Endocrinol Metab Source Type: research

Resistive Intrarenal Index: myth or reality ?
Abstract In renal diagnosis, B-mode ultrasound is used to provide an accurate study of renal morphology, while the colour-power-Doppler is of strategic importance in providing qualitative and quantitative information about the renal vasculature, which can also be obtained through the assessment of 'Resistive Index' (RI). To date, this is one of the most sensitive parameters in the study of kidney diseases and allows us to quantify the changes in renal plasma flow. If a proper Doppler Ultrasound (DUS) examination is carried out and a critical analysis of the values obtained is performed, the RI measurement at the in...
Source: The British Journal of Radiology - April 15, 2014 Category: Radiology Authors: Granata A, Clementi S, Zanoli L, Fatuzzo P, Fiorini F, Di Nicolò P Tags: Br J Radiol Source Type: research

Novel biomarkers to anticipate acute kidney injury. Getting ahead of the curve.
PMID: 24735028 [PubMed - in process] (Source: American Journal of Respiratory and Critical Care Medicine)
Source: American Journal of Respiratory and Critical Care Medicine - April 15, 2014 Category: Respiratory Medicine Authors: Bagshaw SM Tags: Am J Respir Crit Care Med Source Type: research

Non‐invasive assessment of liver steatosis in non‐alcoholic fatty liver disease
ConclusionOur study suggests that while 0% of steatosis showed 1.296 L/S ratio, the cut‐off value of L/S ratio would be 1.1 at least to exclude clinically important liver steatosis. (Source: Hepatology Research)
Source: Hepatology Research - April 15, 2014 Category: Internal Medicine Authors: Hiromi Kan, Yuki Kimura, Hideyuki Hyogo, Takayuki Fukuhara, Hatsue Fujino, Noriaki Naeshiro, Yohji Honda, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Hiroshi Aikata, Hidenori Ochi, Koji Arihiro, Kazuaki Chayama Tags: Original Article Source Type: research

Diagnostic Accuracy of Point-of-Care Tests for Detecting Albuminuria: A Systematic Review and Meta-analysis.
CONCLUSION: A negative semiquantitative POC test result does not rule out albuminuria, whereas quantitative POC testing meets required performance standards and can be used to rule out albuminuria. PRIMARY FUNDING SOURCE: None. PMID: 24733196 [PubMed - in process] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - April 15, 2014 Category: Internal Medicine Authors: McTaggart MP, Newall RG, Hirst JA, Bankhead CR, Lamb EJ, Roberts NW, Price CP Tags: Ann Intern Med Source Type: research

DNA polymorphisms and transcript abundance of PRKAG2 and phosphorylated AMP-activated protein kinase in the rumen are associated with gain and feed intake in beef steers.
Abstract Beef steers with variation in feed efficiency phenotypes were evaluated previously on a high-density SNP panel. Ten markers from rs110125325-rs41652818 on bovine chromosome 4 were associated with average daily gain (ADG). To identify the gene(s) in this 1.2-Mb region responsible for variation in ADG, genotyping with 157 additional markers was performed. Several markers (n = 41) were nominally associated with ADG, and three of these, including the only marker to withstand Bonferroni correction, were located within the protein kinase, AMP-activated, gamma 2 non-catalytic subunit (PRKAG2) gene. An additiona...
Source: Animal Genetics - April 15, 2014 Category: Genetics & Stem Cells Authors: Lindholm-Perry AK, Kuehn LA, Oliver WT, Kern RJ, Cushman RA, Miles JR, McNeel AK, Freetly HC Tags: Anim Genet Source Type: research

Fetal Megacystis: Etiologies, Management, and Outcome According to the Trimester
(Source: Urology)
Source: Urology - April 15, 2014 Category: Urology & Nephrology Authors: Lucile Fievet, Alice Faure, Stéphanie Coze, Luke Harper, Nicoleta Panait, David Braunstein, James Carson, Guillaume Gorincour, Kathia Chaumoitre, Jean-Michel Guys, Pierre Alessandrini, Claude D'Ercole, Thierry Merrot Source Type: research

Evaluation of Current Errors Within the Administration of Phosphodiesterase-5 Inhibitors After More Than 10 Years of Use
(Source: Urology)
Source: Urology - April 15, 2014 Category: Urology & Nephrology Authors: Javier Romero Otero, Borja García Gómez, José Medina Polo, Estíbaliz Jiménez Alcaide, Eduardo García Cruz, Andrea Sallent Font, Alfredo Rodríguez Antolín Source Type: research

Statin Use and the Risk of Recurrence After Radical Prostatectomy in a Cohort of Men With Inherited and/or Early-onset Forms of Prostate Cancer
(Source: Urology)
Source: Urology - April 15, 2014 Category: Urology & Nephrology Authors: Miriam B. Ishak-Howard, Linda A. Okoth, Kathleen A. Cooney Source Type: research

Do Patients With Pelvic Organ Prolapse Have an Increased Frequency of Asymptomatic Microscopic Hematuria?
(Source: Urology)
Source: Urology - April 15, 2014 Category: Urology & Nephrology Authors: Hema D. Brazell, David M. O'Sullivan, Adam C. Steinberg Source Type: research