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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

The effect of aspartate on the energy metabolism in the liver of weanling pigs challenged with lipopolysaccharide
Conclusions These results indicated that dietary supplementation of Asp could improve energy status in LPS-injured liver, which might result from motivating the metabolism pathway of TCA cycle and glycolysis and stimulating the AMPK signaling pathway. (Source: European Journal of Nutrition)
Source: European Journal of Nutrition - May 21, 2015 Category: Nutrition Source Type: research

You CAN worry yourself to death: Anxiety and depression is linked with increased risk of dying from liver disease
People who scored highly for symptoms of psychological distress were more likely to die from liver disease than those with low scores, University of Edinburgh researchers found. (Source: the Mail online | Health)
Source: the Mail online | Health - May 21, 2015 Category: Consumer Health News Source Type: news

Terumo looks to Olympus for GlideWire distribution
Terumo strikes a deal with Olympus for its GlideWire urology device, 2 years after spiking a similar deal with Boston Scientific. Boston Scientific, Olympus, TerumoNews Well, Distribution, Urologyread more (Source: Mass Device)
Source: Mass Device - May 21, 2015 Category: Medical Equipment Authors: Brad Perriello Source Type: news

Smoking ups risk of complications from urologic cancers
Current and former smokers have more complications from major surgery for some urology-related cancers, according to new research.05/21/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 21, 2015 Category: Cancer & Oncology Source Type: news

FDA Regulatory Feedback for Advancing Tivozanib in Renal Cell Carcinoma
Final results now show a median PFS in this setting of 11.0 months and median overall survival (OS) of 21.6 months, demonstrating the efficacy of tivozanib in a VEGF treatment refractory population.05/21/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 21, 2015 Category: Cancer & Oncology Source Type: news

Mother's heartbreak as toddler ravaged by aggressive cancer treatment is left with mottled skin - and given just months to live
Three-year-old J'ssiah Brown, from Camberwell in London, has been given just months to live after his leukaemia returned. Treatment combined with liver failure he suffered has left his skin mottled. (Source: the Mail online | Health)
Source: the Mail online | Health - May 21, 2015 Category: Consumer Health News Source Type: news

Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy.
In this study, we show that hsa-miR-140-5p directly targets Smad2 and overexpression of hsa-miR-140-5p in CRC cell lines decreases Smad2 expression levels, leading decreased cell invasion and proliferation, and increasing cell cycle arrest. Ectopic expression of hsa-miR-140-5p in colorectal CSCs inhibited CSC growth and sphere formation in vitro by disrupting autophagy. We have systematically identified targets of hsa-miR-140-5p involved in autophagy. Furthermore, overexpression of hsa-miR-140-5p in CSCs abolished tumor formation and metastasis in vivo. In addition, there is a progressive loss of hsa-miR-140-5p expression ...
Source: Oncotarget - May 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

A novel Golgi protein (GOLPH2)-regulated oncolytic adenovirus exhibits potent antitumor efficacy in hepatocellular carcinoma.
In this study, a novel dual-regulated oncolytic adenovirus GD55 targeting HCC was first constructed based on our cancer targeted gene-viral therapeutic strategy. To verify the targeting and effectiveness of GOLPH2-regulated oncolytic adenovirus GD55 in HCC, the anticancer capacity was investigated in HCC cell lines and animal model. The results proved that the novel GOLPH2-regulated GD55 conferred higher adenovirus replication and infectivity for liver cancer cells than oncolytic adenovirus ZD55. The GOLPH2-regulated GD55 exerted a significant grow-suppressing effect on HCC cells in vitro but little damage to normal liver ...
Source: Oncotarget - May 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Black market for organs - Five arrested in Spain for trying to buy immigrant's kidney
(NaturalNews) It's a gruesome business, but a thriving one nonetheless: the sale and purchase of human organs on the black market. What's more, it is a "growing industry" that preys on the neediest among us.The trade was revealed again recently when authorities nabbed a Serbian... (Source: NaturalNews.com)
Source: NaturalNews.com - May 21, 2015 Category: Consumer Health Advice Source Type: news

Hepatorenal syndrome: outcome of response to therapy and predictors of survival.
Conclusions. Survival of HRS patients after treatment depends on age, etiology of liver disease, and the duration of treatment. PMID: 25983746 [PubMed] (Source: Gastroenterology Research and Practice)
Source: Gastroenterology Research and Practice - May 21, 2015 Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research

Thirty-day VARC-2 and performance data of a new self-expanding transcatheter aortic heart valve.
CONCLUSIONS: In this first-in-human study, the feasibility of implantation of the BIOVALVE system and its re-sheathing functionality was demonstrated, and short-term safety data were encouraging. Larger studies are required to confirm the performance of the device. PMID: 25983028 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - May 21, 2015 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Statin use prior to angiography for the prevention of contrast-induced acute kidney injury: a meta-analysis of 19 randomised trials.
CONCLUSIONS: This meta-analysis suggests a potential benefit for statin use prior to angiography to reduce the incidence of CI-AKI. Additional research is needed to define better the benefits of statin therapy prior to angiography to prevent CI-AKI, especially in high-risk patients with chronic kidney disease who were largely underrepresented in the available trials. PMID: 25982920 [PubMed - as supplied by publisher] (Source: EuroIntervention)
Source: EuroIntervention - May 21, 2015 Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research

Best and safest blood pressure treatments in kidney and diabetes patients compiled
(University of Otago) The first definitive summary of the best and safest blood pressure lowering treatments for kidney disease and diabetes patients has been compiled by New Zealand doctor and researcher Associate Professor Suetonia Palmer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 21, 2015 Category: Global & Universal Source Type: news

Association between hypoglycaemia and impaired hypoglycaemia awareness and mortality in people with Type 1 diabetes mellitus
ConclusionsSevere hypoglycaemia and hypoglycaemia unawareness are not associated with increased risk of all‐cause or cardiovascular mortality in people with Type 1 diabetes mellitus.This article is protected by copyright. All rights reserved. (Source: Diabetic Medicine)
Source: Diabetic Medicine - May 21, 2015 Category: Endocrinology Authors: A.‐S. Sejling, B. Schouwenberg, L. H. Færch, B. Thorsteinsson, B. E. de Galan, U. Pedersen‐Bjergaard Tags: Research Article Source Type: research

Quantitative R2* MRI of the liver with rician noise models for evaluation of hepatic iron overload: Simulation, phantom, and early clinical experience
ConclusionRician R2* estimates were most consistent in the high R2* conditions and under varying SNR, and may be more reliable when high iron load is suspected. J. Magn. Reson. Imaging 2015. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - May 21, 2015 Category: Radiology Authors: Takeshi Yokoo, Qing Yuan, Julien Sénégas, Andrea J. Wiethoff, Ivan Pedrosa Tags: Original Research Source Type: research

MR relaxometry in chronic liver diseases: comparison of T1 mapping, T2 mapping, and diffusion-weighted imaging for assessing cirrhosis diagnosis and severity
Conclusion Liver T1 mapping is a promising new diagnostic tool for assessing cirrhosis diagnosis and severity, showing higher diagnostic accuracy than liver and spleen DWI, while T2 mapping is not reliable. (Source: European Journal of Radiology)
Source: European Journal of Radiology - May 21, 2015 Category: Radiology Source Type: research

Toward a standard technique for laparoscopic distal pancreatectomy? Synthesis of the 2013 ACHBT Spring workshop
Publication date: Available online 21 May 2015 Source:Journal of Visceral Surgery Author(s): K. Mohkam , O. Farges , F.-R. Pruvot , F. Muscari , J.-M. Régimbeau , N. Regenet , A. Sa Cunha , S. Dokmak , J.-Y. Mabrut Laparoscopic distal pancreatectomy is currently a commonly performed procedure. Twenty-five retrospective studies comparing laparotomy and laparoscopy have dealt with the feasibility of this approach for localized benign and malignant tumors. However, these studies report several different techniques. The aim of this review was to determine if a standardized procedure could be proposed. Based on the literatur...
Source: Journal of Visceral Surgery - May 21, 2015 Category: Surgery Source Type: research

Urinary catheterization diary – A useful tool in tracking causes of non-deflating Foley catheter
Conclusions Most urinary catheters marketed in developing countries are unidentifiable after unpacking. A catheterization diary is a useful tool for solving catheter-related problems, and its application in health-care facilities should be encouraged. Companies marketing Foley catheters should print the catheter name on both the catheter packaging and on the catheter itself. (Source: African Journal of Urology)
Source: African Journal of Urology - May 21, 2015 Category: Global & Universal Source Type: research

Association of Drug Effects on Serum Parathyroid Hormone, Phosphorus, and Calcium Levels With Mortality in CKD: A Meta-analysis
Conclusions Drug effects on serum PTH, phosphorus, and calcium levels are weakly and imprecisely correlated with all-cause and cardiovascular death in the setting of CKD. Risks of mortality (patient-level outcome) cannot be inferred from treatment-induced changes in biochemical outcomes in people with CKD. Similarly, existing data do not exclude a mortality benefit with treatment. Trials need to address patient-centered outcomes to evaluate drug effectiveness in this setting. (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - May 21, 2015 Category: Urology & Nephrology Source Type: research

Calcium oxalate calculi-induced clusterin expression in kidney
Abstract The aim of the study was to investigate clusterin expression in the kidney and evaluate the urine clusterin level in the kidney stone formers. (1) In vitro, we treated the Madin-Darby canine kidney (MDCK) cell line with different concentrations of calcium oxalate (CaOx), and then the clusterin protein expression in the cells was evaluated by Western blotting. (2) Kidney stone patients who received percutaneous nephrolithotomy were enrolled in our study. Urine samples were collected before surgery, the kidney punctured to obtain kidney tissue guided by ultrasound intraoperatively. Clusterin expression in t...
Source: Urolithiasis - May 21, 2015 Category: Urology & Nephrology Source Type: research

Are currently GFR estimating equations and standard Kt/V value adequate for advanced chronic kidney disease (CKD) frail elderly patients?
In conclusion, based on all these facts, it seems crucial for clinical geriatric nephrology to carefully evaluate how reliable current GFR estimating equations are, as well as which would be an adequate Kt/V value in CKD frail elderly patients. (Source: International Urology and Nephrology)
Source: International Urology and Nephrology - May 21, 2015 Category: Urology & Nephrology Source Type: research

Scoping review of adherence promotion theories in pelvic floor muscle training ‐ 2011 ICS State‐of‐the‐Science Seminar research paper I of IV
ConclusionA better theoretical‐based understanding of interventions to promote PFMT adherence through changes in health behaviors is required. The results of this scoping review and expert opinions identified several promising models. Future research should explicitly map the theories behind interventions that are thought to improve adherence in various populations (e.g., perinatal women to prevent or lessen urinary incontinence). In addition, identified behavioral theories applied to PFMT require a process whereby their impact can be evaluated. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - May 21, 2015 Category: Urology & Nephrology Authors: Doreen McClurg, Helena Frawley, Jean Hay‐Smith, Sarah Dean, Shu‐Yueh Chen, Pauline Chiarelli, Frances Mair, Chantale Dumoulin Tags: Review Article Source Type: research

Pelvic‐floor‐muscle training adherence: Tools, measurements and strategies—2011 ICS State‐of‐the‐Science Seminar research paper II
ConclusionThe literature on adherence outcome measures, determinants and strategies remains scarce for the studied populations with PFM dysfunction, except in women with UI. Although some current adherence findings can be applied to clinical practice, more effective and standardized research is urgently needed across all the sub‐populations. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - May 21, 2015 Category: Urology & Nephrology Authors: Chantal Dumoulin, Dianne Alewijnse, Kari Bo, Suzanne Hagen, Diane Stark, Marijke Van Kampen, Julia Herbert, Jean Hay‐Smith, Helena Frawley, Doreen McClurg, Sarah Dean Tags: Review Article Source Type: research

Pelvic‐floor‐muscle‐training adherence “modifiers”: A review of primary qualitative studies—2011 ICS State‐of‐the‐Science Seminar research paper III of IV
ConclusionsIndividuals' experience substantial difficulties with capability (particularly knowledge and skills), motivation (especially associated with the considerable cognitive demands of PFMT), and opportunity (as external factors generate competing priorities) when adopting and maintaining a PFMT program. Expert consensus was that judicious selection and deliberate application of appropriate behavior change strategies directed to the “modifiers” of adherence identified in the review may improve PFMT outcomes. Future research is needed to explore whether the review findings are congruent with the PFMT experiences of...
Source: Neurourology and Urodynamics - May 21, 2015 Category: Urology & Nephrology Authors: Jean Hay‐Smith, Sarah Dean, Kathryn Burgio, Doreen McClurg, Helena Frawley, Chantale Dumoulin Tags: Review Article Source Type: research

Health professionals’ and patients’ perspectives on pelvic floor muscle training adherence—2011 ICS State‐of‐the‐Science Seminar research paper IV of IV
ConclusionsAn emphasis on “patient‐related” factors, ahead of “condition‐specific” and “therapy‐related,” affecting PFMT adherence barriers was evident. Health professionals need to be aware of the importance of long‐term patient perception of PFMT benefits and consider enabling strategies. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc. (Source: Neurourology and Urodynamics)
Source: Neurourology and Urodynamics - May 21, 2015 Category: Urology & Nephrology Authors: Helena C. Frawley, Doreen McClurg, Aishath Mahfooza, Jean Hay‐Smith, Chantale Dumoulin Tags: Review Article Source Type: research

2014 consensus statement on improving pelvic floor muscle training adherence: International Continence Society 2011 State‐of‐the‐Science Seminar
ConclusionGiven the lack of high‐quality studies, the conclusions were informed by expert opinion. Adherence is central to short‐ and longer‐term PFMT effect. More attention and explicit reporting is needed regarding: (1) applying health behavior theory in PFMT program planning; (2) identifying adherence determinants; (3) developing and implementing interventions targeting known adherence determinants; (4) using patient‐centred approaches to evaluating adherence barriers and facilitators; (5) measuring adherence, including refining and testing instruments; and (6) testing the association between adherence and PFMT ...
Source: Neurourology and Urodynamics - May 21, 2015 Category: Urology & Nephrology Authors: Chantale Dumoulin, Jean Hay‐Smith, Helena Frawley, Doreen McClurg, Dianne Alewijnse, Kari Bo, Kathryn Burgio, Shu‐Yueh Chen, Pauline Chiarelli, Sarah Dean, Suzanne Hagen, Julia Herbert, Aishath Mahfooza, Frances Mair, Diane Stark, Marijke Van Kampen Tags: Review Article Source Type: research

Pathologic Lymph Node–positive Prostate Cancer: Some Answers … with Many More Questions
Publication date: Available online 21 May 2015 Source:European Urology Author(s): Debasish Sundi , Edward M. Schaeffer (Source: European Urology)
Source: European Urology - May 21, 2015 Category: Urology & Nephrology Source Type: research

Prevalence of CMMSE defined cognitive impairment among peritoneal dialysis patients and its impact on peritonitis
Conclusion CI is common among local PD patients. Overall, CI could not be identified as an independent risk factor for PD peritonitis. There is a higher prevalence of CI among assisted PD patients but helpers may not completely eliminate the risk of PD-related peritonitis. (Source: Clinical and Experimental Nephrology)
Source: Clinical and Experimental Nephrology - May 21, 2015 Category: Urology & Nephrology Source Type: research

Acute and subchronic effects on immune responses of carp ( Cyprinus carpio L.) after exposure to deoxynivalenol (DON) in feed
Abstract The mycotoxin deoxynivalenol (DON) has been shown to regularly occur at relevant concentrations in feed designed for aquaculture use, but little is known about the consequences of its presence on the organisms that consume the DON-contaminated feed. Previous studies indicated a down-regulation of pro-inflammatory responses in carp (Cyprinus carpio L.) after 4 weeks of feeding DON. The present study examined the time course of innate immune responses of carp to orally administered DON. Changes in mRNA levels of immune genes in different organs (head kidney, trunk kidney, spleen, liver, and intestine) were...
Source: Mycotoxin Research - May 21, 2015 Category: Toxicology Source Type: research

Relation of cytokeratin 18-Apoptosense M30 to activity and fibrosis in chronic HCV patients
Publication date: Available online 20 May 2015 Source:Egyptian Journal of Basic and Applied Sciences Author(s): Walid Ahmed El-Sherbiny , Raghda El-Sayed Farag , Azza Abd El-Baky El-Baiomy , Rania Ahmed El-Erian Hepatitis C virus (HCV) is a progressive disease that may result in Chronic active hepatitis, cirrhosis, and hepatocellular carcinoma. Cytokeratin(CK)18 is an intermediary filament protein, expressed in hepatocytes, which is proteolytically cleaved during liver damage. M30 epitope of cytokeratin18(CK18-M30) is involved at different levels in apoptotic pathways. The aim of this study to investigate the diagnostic ...
Source: Egyptian Journal of Basic and Applied Sciences - May 21, 2015 Category: Science Source Type: research

Inulin, a flexible oligosaccharide I: Review of its physicochemical characteristics
Publication date: Available online 20 May 2015 Source:Carbohydrate Polymers Author(s): Maarten A. Mensink , Henderik W. Frijlink , Kees van der Voort Maarschalk , Wouter L.J. Hinrichs Inulin, a fructan-type polysaccharide, consists of (2→1) linked ß-D-fructosyl residues (n=2-60), usually with an (1↔2) α-D-glucose end group. The applications of inulin and its hydrolyzed form oligofructose (n=2-10) are diverse. It is widely used in food industry to modify texture, replace fat or as low-calorie sweetener. Additionally, it has several applications in other fields like the pharmaceutical arena. Most notably it is used a...
Source: Carbohydrate Polymers - May 21, 2015 Category: Biomedical Science Source Type: research

Evidence for the Presence of Glucosensor Mechanisms Not Dependent on Glucokinase in Hypothalamus and Hindbrain of Rainbow Trout (Oncorhynchus mykiss)
by Cristina Otero-Rodiño, Marta Librán-Pérez, Cristina Velasco, Marcos A. López-Patiño, Jesús M. Míguez, José L. Soengas We hypothesize that glucosensor mechanisms other than that mediated by glucokinase (GK) operate in hypothalamus and hindbrain of the carnivorous fish species rainbow trout and stress affected them. Therefore, we evaluated in these areas changes in parameters which could be related to putative glucosensor mechanisms based on liver X receptor (LXR), mitochondrial activity, sweet taste receptor, and sodium/glucose co-transporter 1 (SGLT-1) 6h after intraperitoneal injection of 5 mL.Kg-1 of saline s...
Source: PLoS One - May 21, 2015 Category: Biomedical Science Authors: Cristina Otero-Rodiño et al. Source Type: research

A spatially-averaged mathematical model of kidney branching morphogenesis
Publication date: 21 August 2015 Source:Journal of Theoretical Biology, Volume 379 Author(s): V.S. Zubkov , A.N. Combes , K.M. Short , J. Lefevre , N.A. Hamilton , I.M. Smyth , M.H. Little , H.M. Byrne Kidney development is initiated by the outgrowth of an epithelial ureteric bud into a population of mesenchymal cells. Reciprocal morphogenetic responses between these two populations generate a highly branched epithelial ureteric tree with the mesenchyme differentiating into nephrons, the functional units of the kidney. While we understand some of the mechanisms involved, current knowledge fails to explain the variability...
Source: Journal of Theoretical Biology - May 21, 2015 Category: Biology Source Type: research

Elderly donor liver grafts are not associated with a higher incidence of biliary complications after liver transplantation: results of a national multicenter study
ConclusionTransplantation of livers from elderly donors (≥ 65 years) is not associated with a higher incidence of biliary complications, in a national policy wherein the cold ischemia time is kept short.This article is protected by copyright. All rights reserved. (Source: Clinical Transplantation)
Source: Clinical Transplantation - May 21, 2015 Category: Transplant Surgery Authors: Andrie C. Westerkamp, Kerem S. Korkmaz, Jan T. Bottema, Jan Ringers, Wojciech G. Polak, Aad den Berg, Bart Hoek, Herold J. Metselaar, Robert J. Porte Tags: Original Article Source Type: research

The renal effects of mineralocorticoid receptor antagonists
Beyond its well known classic effects on renal water and electrolytes metabolism, an increasing amount of experimental and clinical evidence suggests that aldosterone contributes to the pathogenesis and progression of kidney disease. Binding of aldosterone on epithelial and non epithelial cells of the kidney induces many deleterious effects, such as podocyte apoptosis and injury, mesangial cell proliferation and deformability and tubulointerstitial inflammation, finally resulting in glomerular fibrosis and sclerosis. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 21, 2015 Category: Cardiology Authors: Stefano Bianchi, Valentina Batini, Roberto Bigazzi Tags: Review Source Type: research

Viruses, Vol. 7, Pages 2507-2517: IPNV Antigen Uptake and Distribution in Atlantic Salmon Following Oral Administration
One impediment to the successful oral vaccination in fish is the hostile stomach environment that antigens must cross. Furthermore, uptake of antigens from the gut to systemic distribution is required for induction of systemic immunity, the dynamics of which are poorly understood. In the present study, groups of Atlantic salmon parr were intubated with live or inactivated infectious pancreatic necrosis virus (IPNV), either orally or anally. At 1, 24 and 72 h post infection (p.i.), the fish were sacrificed. Serum was used for assessing IPNV by ELISA, while formalin-fixed head-kidney, spleen, liver and intestine tissues were...
Source: Viruses - May 21, 2015 Category: Virology Authors: Lihan ChenØystein EvensenStephen Mutoloki Tags: Communication Source Type: research

Effects of 10 to 30 years of lithium treatment on kidney function
Long-term lithium treatment is associated with end-stage renal disease, but there is little evidence of a clinically significant reduction in renal function in most patients. We previously found that 1.5% of people who took lithium from the 1960s and 1970s developed end-stage renal disease; however, none of the patients who started after 1980 had end-stage renal disease. Here we aimed to study the prevalence and extent of kidney damage during the course of long-term lithium treatment since 1980. We retrieved serum lithium and creatinine levels from 4879 patients examined between 1 January 1981 and 31 December 2010. Only pa...
Source: Journal of Psychopharmacology - May 21, 2015 Category: Psychiatry Authors: Aiff, H., Attman, P.-O., Aurell, M., Bendz, H., Ramsauer, B., Schon, S., Svedlund, J. Tags: Original Papers Source Type: research

The Impact of Fluid Balance on the Detection, Classification and Outcome of Acute Kidney Injury After Cardiac Surgery
To assess whether or not a positive fluid balance masks acute kidney injury (AKI) and is associated with adverse outcomes after cardiac surgery. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - May 21, 2015 Category: Anesthesiology Authors: Elizabeth Moore, Antony Tobin, David Reid, John Santamaria, Eldho Paul, Rinaldo Bellomo Tags: Original Article Source Type: research

Safety, tolerability, and efficacy of oxaliplatin-based adjuvant chemotherapy after curative resection of hepatic or extrahepatic metastases of Stage IV colorectal cancer
Conclusions Oxaliplatin-based adjuvant chemotherapy could be an effective option for selected patients with Stage IV CRC after curative resection of hepatic or extrahepatic metastases, and is both safe and tolerable. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - May 21, 2015 Category: Cancer & Oncology Source Type: research

Survival of patients with advanced lung adenocarcinoma before and after approved use of gefitinib in China
ConclusionsGefitinib treatment significantly improved the survival of patients with advanced lung adenocarcinoma in China. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 21, 2015 Category: Cancer & Oncology Authors: Yu‐Tao Liu, Xue‐Zhi Hao, Jun‐Ling Li, Xing‐Sheng Hu, Yan Wang, Zi‐Ping Wang, Hong‐Yu Wang, Bin Wang, Xiao‐Hong Han, Xiang‐Ru Zhang, Yuan‐Kai Shi Tags: Original Article Source Type: research

Human {beta}-Cell Proliferation and Intracellular Signaling: Part 3
This is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferation in pancreatic β-cells. We contrast the large knowledge base in rodent β-cells with the more limited human database. With the increasing incidence of type 1 diabetes and the recognition that type 2 diabetes is also due in part to a deficiency of functioning β-cells, there is great urgency to identify therapeutic approaches to expand human β-cell numbers. Therapeutic approaches might include stem cell differentiation, transdifferentiation, or expansion of cadaver islets or residual endogenous β-...
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Stewart, A. F.; Hussain, M. A.; Garcia-Ocana, A.; Vasavada, R. C.; Bhushan, A.; Bernal-Mizrachi, E.; Kulkarni, R. N. Tags: Perspectives in Diabetes Source Type: research

Bleach in the Diabetic Kidney Destabilizes Basement Membrane Collagen
(Source: Diabetes)
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Monnier, V. M. Tags: Commentaries Source Type: research

Liver-Specific Expression of Dominant-Negative Transcription Factor 7-Like 2 Causes Progressive Impairment in Glucose Homeostasis
Investigations on the metabolic role of the Wnt signaling pathway and hepatic transcription factor 7-like 2 (TCF7L2) have generated opposing views. While some studies demonstrated a repressive effect of TCF7L2 on hepatic gluconeogenesis, a recent study using liver-specific Tcf7l2–/– mice suggested the opposite. As a consequence of redundant and bidirectional actions of transcription factor (TCF) molecules and other complexities of the Wnt pathway, knockout of a single Wnt pathway component may not effectively reveal a complete metabolic picture of this pathway. To address this, we generated the liver-specific d...
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Ip, W.; Shao, W.; Song, Z.; Chen, Z.; Wheeler, M. B.; Jin, T. Tags: Metabolism Source Type: research

A Mutant Allele Encoding DNA Binding-Deficient FoxO1 Differentially Regulates Hepatic Glucose and Lipid Metabolism
In this study, we investigated the pleiotropic actions of FoxO1 on glucose and lipid metabolism. To this end, we reconstituted FoxO1 function in mice with a liver-specific deletion of Foxo1 using targeted knock-in of an allele encoding a DNA binding–deficient FoxO1 mutant (L-DBD). Chow-reared L-DBD mice showed defects in hepatic glucose production but normal liver triglyceride content despite increased rates of de novo lipogenesis and impaired fatty acid oxidation in isolated hepatocytes. Gene expression studies indicated that FoxO1 regulates the expression of glucokinase via a cell-nonautonomous coregulatory mechani...
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Cook, J. R.; Matsumoto, M.; Banks, A. S.; Kitamura, T.; Tsuchiya, K.; Accili, D. Tags: Metabolism Source Type: research

Effects of Intranasal Insulin on Hepatic Fat Accumulation and Energy Metabolism in Humans
In conclusion, intranasal insulin does not affect HIS but rapidly improves hepatic energy metabolism in healthy humans, which is independent of peripheral insulinemia. These effects are blunted in patients with type 2 diabetes. (Source: Diabetes)
Source: Diabetes - May 21, 2015 Category: Endocrinology Authors: Gancheva, S.; Koliaki, C.; Bierwagen, A.; Nowotny, P.; Heni, M.; Fritsche, A.; Haring, H.-U.; Szendroedi, J.; Roden, M. Tags: Metabolism Source Type: research