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Urology & Nephrology

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Is it possible to achieve anything MORE going down the LESS route?
(Source: BJU International)
Source: BJU International - September 24, 2014 Category: Urology & Nephrology Authors: Amrith Raj Rao Tags: Editorial Source Type: research

Treatment satisfaction with tadalafil or tamsulosin vs placebo in men with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH): results from a randomised, placebo‐controlled study
ConclusionTreatment satisfaction was greater with tadalafil vs placebo, with no significant difference between tamsulosin and placebo. (Source: BJU International)
Source: BJU International - September 24, 2014 Category: Urology & Nephrology Authors: Matthias Oelke, François Giuliano, Simin K. Baygani, Thomas Melby, Angelina Sontag Tags: Functional Urology Source Type: research

Management of calyceal diverticular calculi: a comparison of percutaneous nephrolithotomy and flexible ureterorenoscopy
Abstract To compare the outcomes in patients who have been treated with flexible ureterorenoscopy (f-URS) and percutaneous nephrolithotomy (PNL) in managing stone-bearing caliceal diverticula. Between April 2007 and October 2013, we performed a retrospective analysis of 54 evaluable patients (28 women and 26 men) with symptomatic stone-bearing caliceal diverticula, who underwent PNL (n = 29) or F-URS (n = 25) in four referral hospitals in Turkey. The groups were compared with respect to demographics, stone location/size, success rate, stone-free status, symptom-free status, complication rates, and hospital sta...
Source: Urolithiasis - September 24, 2014 Category: Urology & Nephrology Source Type: research

Stigmata of death: for kidneys and patients
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Ronco, C., Bonventre, J. V. Tags: IN FOCUS Source Type: research

More light shed on light chains
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Paueksakon, P., Fogo, A. B. Tags: IN FOCUS Source Type: research

Optimal and early detection of acute kidney injury requires effective clinical decision support systems
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Handler, S. M., Kane-Gill, S. L., Kellum, J. A. Tags: IN FOCUS Source Type: research

Peritoneal dialysis outcomes after temporary haemodialysis for peritonitis--influence on current practice
(Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Donovan, K., Carrington, C. Tags: IN FOCUS Source Type: research

Representation of exposures in regression analysis and interpretation of regression coefficients: basic concepts and pitfalls
The objective of this educational paper was to illustrate these fundamentals and pitfalls, using various multiple regression models applied to data from a hypothetical cohort of 3000 patients with chronic kidney disease. In particular, we illustrate how to represent different types of exposure variables (binary, categorical with two or more categories and continuous), and how to interpret the regression coefficients in linear, logistic and Cox models. We also discuss the linearity assumption in these models, and show how wrongly assuming linearity may produce biased results and how flexible modelling using spline functions...
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Leffondre, K., Jager, K. J., Boucquemont, J., Stel, V. S., Heinze, G. Tags: NDT PERSPECTIVES Source Type: research

Is chronic kidney disease-mineral bone disorder (CKD-MBD) really a syndrome?
The concept of chronic kidney disease–mineral bone disorder (CKD-MBD) does not appear to fulfil the requirements for a syndrome at first glance, but its definition has brought some clear-cut benefits for clinicians and patients, including wider and more complex diagnostic and therapeutic approaches to the management of this challenging set of issues. Admittedly, not all components of CKD-MBD are present in all patients at all times, but these are highly interrelated, involving mineral and bone laboratory abnormalities, clinical and histological bone disease and finally, cardiovascular disease. The presence of typical...
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Cozzolino, M., Urena-Torres, P., Vervloet, M. G., Brandenburg, V., Bover, J., Goldsmith, D., Larsson, T. E., Massy, Z. A., Mazzaferro, S., on behalf of the CKD-MBD Working Group of ERA-EDTA Tags: NDT PERSPECTIVES Source Type: research

Epigenetics: a new way to look at kidney diseases
Only a few percent of the 3 billion pairs of chemical letters in the human genome is responsible for protein-coding sequences. Recent advances in the field of epigenomics have helped us to understand how most of the remaining sequences are responsible for gene regulation at baseline and in disease conditions. Here we discuss recent advances in the area of epigenetics—specifically in cytosine modifications—and its application in the field of nephrology. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Beckerman, P., Ko, Y.-A., Susztak, K. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Ischaemic conditioning strategies for the nephrologist: a promise lost in translation?
Over the last quarter of a century, a huge effort has been made to develop interventions that can minimise ischaemia reperfusion injury. The most potent of these are the ischaemic conditioning strategies, which comprise ischaemic preconditioning, remote ischaemic preconditioning and ischaemic postconditioning. While much of the focus for these interventions has been on protecting the myocardium, other organs including the kidney can be similarly protected. However, translation of these beneficial effects from animal models into routine clinical practice has been less straightforward than expected. In this review, we examin...
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: McCafferty, K., Byrne, C., Yaqoob, M. M. Tags: REVIEWS - BASIC SCIENCE AND TRANSLATIONAL NEPHROLOGY Source Type: research

Treatment of renal sarcoidosis: is there a guideline? Overview of the different treatment options
Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by the presence of noncaseating granulomas. It may affect any organ including the kidney. A disordered calcium metabolism is most often responsible for the development of renal failure. Granulomatous interstitial nephritis is the most typical histological finding, but it rarely leads to renal insufficiency. Since development of renal insufficiency in sarcoidosis is uncommon, we lack large (randomized) trials concerning the treatment of this disorder. We gather most information from case reports and small series. Our knowledge of pulmonary...
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Hilderson, I., Van Laecke, S., Wauters, A., Donck, J. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

A look at the upper heart chamber: the left atrium in chronic kidney disease
Altered left ventricular (LV) mass and function are classical hallmarks of cardiomyopathy in chronic kidney disease (CKD). The left atrium (LA), a heart chamber exquisitely sensitive to volume overload and diastolic function, is an independent predictor of death and adverse cardiovascular (CV) events in high-risk patients such as those with hypertension and/or with heart failure. In this review we focus on the relationship of LA size with LV diastolic function, and the association between LA enlargement and CV and renal outcomes in patients with CKD, including patients with end-stage renal disease. Increased LA size emerge...
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Paoletti, E., Zoccali, C. Tags: REVIEWS - CLINICAL SCIENCE AND OUTCOME RESEARCH IN NEPHROLOGY Source Type: research

Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy
Conclusions Elevated plasma concentrations of inflammatory and apoptosis biomarkers are associated with RRT dependence and death. Our data suggest that future interventions should investigate broad-spectrum immune-modulation to improve outcomes. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Murugan, R., Wen, X., Shah, N., Lee, M., Kong, L., Pike, F., Keener, C., Unruh, M., Finkel, K., Vijayan, A., Palevsky, P. M., Paganini, E., Carter, M., Elder, M., Kellum, J. A., for the Biological Markers for Recovery of Kidney (BioMaRK) Study Investigato Tags: BASIC SCIENCE Source Type: research

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation
Conclusions Inflammatory stress can disrupt HMGCoA-R-mediated cholesterol synthesis resulting in intracellular lipid accumulation and statin resistance. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Chen, Y., Zhao, L., Li, Q., Wheeler, D. C., Varghese, Z., Moorhead, J. F., Powis, S. H., Ruan, X. Z. Tags: BASIC SCIENCE Source Type: research

The effect of FoxO1 on the proliferation of rat mesangial cells under high glucose conditions
Conclusions Overexpression of FoxO1 caused upregulation of p27, which promoted cell cycle arrest and inhibited hyperproliferation of MCs induced by HG. Degradation of FoxO1 caused an increase in p27 and stimulated MC proliferation. These findings unveil part of the molecular mechanism of FoxO1 regulation of MC hyperproliferation induced by HG. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Liu, F., Ma, X.-J., Wang, Q.-Z., Zhao, Y.-Y., Wu, L.-N., Qin, G.-J. Tags: BASIC SCIENCE Source Type: research

A real-time electronic alert to improve detection of acute kidney injury in a large teaching hospital
Conclusions This is the first fully automated real time AKI e-alert system, using AKIN and RIFLE criteria, to be introduced to a large National Health Service hospital. It has provided one of the biggest single-centre AKI datasets in the UK revealing mortality rates which increase with AKI stage. It is likely to have improved detection and management of AKI. The methodology is transferable to other acute hospitals. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Porter, C. J., Juurlink, I., Bisset, L. H., Bavakunji, R., Mehta, R. L., Devonald, M. A. J. Tags: Acute Kidney Injury Source Type: research

Light chain deposition disease without glomerular proteinuria: a diagnostic challenge for the nephrologist
Conclusions LCDD can cause severe renal dysfunction, despite the absence of glomerular symptoms. Early identification of the disease and introduction of a chemotherapy targeting the underlying plasma cell disorder may preserve long-term renal prognosis. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Sicard, A., Karras, A., Goujon, J.-M., Sirac, C., Bender, S., Labatut, D., Callard, P., Sarkozy, C., Essig, M., Vanhille, P., Provot, F., Nony, A., Nochy, D., Ronco, P., Bridoux, F., Touchard, G. Tags: Chronic Kidney Disease Source Type: research

Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population
Conclusions FHH should be clearly differentiated by PHPT to avoid unnecessary surgery: CCCR could be a useful screening tool while genetic analysis should include the two novel CaSR mutations herein described. The role of multiple polymorphisms deserves further investigation in patients with an FHH phenotype. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Stratta, P., Merlotti, G., Musetti, C., Quaglia, M., Pagani, A., Izzo, C., Radin, E., Airoldi, A., Baorda, F., Palladino, T., Leone, M. P., Guarnieri, V. Tags: Acute Kidney Injury Source Type: research

Epidemiology of patients in England and Wales with autosomal dominant polycystic kidney disease and end-stage renal failure
Conclusion Although engaged in renal services earlier than some other patient groups, individuals with ADPKD start RRT at a younger age and this has remained unchanged over the last decade. Developing a nationwide cohort and an enhanced disease-specific dataset would facilitate a wide range of research and quality improvement initiatives to try to modify progression to ESRF and the course of RRT. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Shaw, C., Simms, R. J., Pitcher, D., Sandford, R. Tags: Acute Kidney Injury Source Type: research

Tacrolimus therapy in adult-onset steroid-resistant nephrotic syndrome due to a focal segmental glomerulosclerosis single-center experience
Conclusion TAC is an effective agent in the management of SR-FSGS. However, strict renal function and blood sugar monitoring is required due to its potential nephrotoxicity and diabetogenic potential. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Ramachandran, R., Kumar, V., Rathi, M., Nada, R., Jha, V., Gupta, K. L., Sakhuja, V., Kohli, H. S. Tags: Acute Kidney Injury Source Type: research

Rituximab treatment for fibrillary glomerulonephritis
Conclusions Rituximab therapy was associated with non-progression of renal disease in 4 of 12 patients. At the time of treatment, these non-progressors had better renal function and shorter time from diagnosis to treatment than progressors. Keywords: Glomerular disease, nephrotic syndrome, proteinuria (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Hogan, J., Restivo, M., Canetta, P. A., Herlitz, L. C., Radhakrishnan, J., Appel, G. B., Bomback, A. S. Tags: Acute Kidney Injury Source Type: research

The impact of elevation of serum uric acid level on the natural history of glomerular filtration rate (GFR) and its sex difference
Conclusions The results indicate that elevation of SUA accelerates the yearly decline in eGFR and that women are more susceptible to urate-induced decline in eGFR. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Akasaka, H., Yoshida, H., Takizawa, H., Hanawa, N., Tobisawa, T., Tanaka, M., Moniwa, N., Togashi, N., Yamashita, T., Kuroda, S., Ura, N., Miura, T., BOREAS-CKD1 Investigators Tags: Acute Kidney Injury Source Type: research

Peritoneal dialysis outcomes after temporary haemodialysis transfer for peritonitis
Conclusions In an observational registry study of first peritonitis episodes, temporary HD transfer was not associated with inferior patient-level clinical outcomes when compared with others who either never required HD transfer or remained on HD permanently if all patient-level and peritonitis-related factors were considered equal. Therefore, return to PD after a temporary HD due to peritonitis should not be discouraged in appropriate PD patients. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Cho, Y., Badve, S. V., Hawley, C. M., McDonald, S. P., Brown, F. G., Boudville, N., Clayton, P., Johnson, D. W. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Effects of intradialytic cycling compared with pedometry on physical function in chronic outpatient hemodialysis: a prospective randomized trial
Conclusions Both intradialytic cycling and pedometer programming improved aspects of physical function. Neither intervention had a significant effect on aerobic capacity. No significant differences in any outcomes were identified between interventions groups. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Bohm, C., Stewart, K., Onyskie-Marcus, J., Esliger, D., Kriellaars, D., Rigatto, C. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research

Use of vascular access for haemodialysis in Europe: a report from the ERA-EDTA Registry
Conclusion In Europe, there is a decreasing trend in the use of AVFs and an increasing trend in the use of CVCs at the start and after the start of HD. We cannot explain all between-country variations we found, and more research is needed to clarify how healthcare around vascular access is organized in Europe. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - September 24, 2014 Category: Urology & Nephrology Authors: Noordzij, M., Jager, K. J., van der Veer, S. N., Kramar, R., Collart, F., Heaf, J. G., Stojceva-Taneva, O., Leivestad, T., Buturovic-Ponikvar, J., Benitez Sanchez, M., Moreso, F., Prutz, K. G., Severn, A., Wanner, C., Vanholder, R., Ravani, P. Tags: Intra- and Extracorporeal Treatments of Kidney Failure Source Type: research