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Urology & Nephrology

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Caspase-1 inhibition alleviates acute renal injury in rats with severe acute pancreatitis.
CONCLUSION: The expression of caspase-1-activated cytokines IL-1β and IL-18 plays a pivotal role in acute renal injury in rats with experimental SAP. Caspase-1 inhibition improves renal function effectively. PMID: 25132762 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Zhang XH, Li ML, Wang B, Guo MX, Zhu RM Tags: World J Gastroenterol Source Type: research

Insulin resistance, adipokine profile and hepatic expression of SOCS-3 gene in chronic hepatitis C.
CONCLUSION: We speculated that no relationship between adipokines and HOMA-IR values may indicate that HCV can induce insulin resistance itself. Some adipokines appear to be biochemical markers of steatosis, inflammation and fibrosis in patients with chronic HCV infection. © 2014 Baishideng Publishing Group Inc. All rights reserved. PMID: 25132761 [PubMed - in process] (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Wójcik K, Jabłonowska E, Omulecka A, Piekarska A Tags: World J Gastroenterol Source Type: research

Hepatitis B vaccine by intradermal route in non responder patients: An update.
Abstract Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined "no responders". Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney...
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Filippelli M, Lionetti E, Gennaro A, Lanzafame A, Arrigo T, Salpietro C, La Rosa M, Leonardi S Tags: World J Gastroenterol Source Type: research

Current management of hepatocellular carcinoma.
Abstract Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and leading cause of death among patients with cirrhosis. Treatment guidelines are based according to the Barcelona Clinic Liver Cancer staging system. The choice among therapeutic options that include liver resection, liver transplantation, locoregional, and systemic treatments must be individualized for each patient. The aim of this paper is to review the outcomes that can be achieved in the treatment of HCC with the heterogeneous therapeutic options currently available in clinical practice. PMID: 25132740 [PubMed - as supplied ...
Source: World Journal of Gastroenterology - August 14, 2014 Category: Gastroenterology Authors: Tabrizian P, Roayaie S, Schwartz ME Tags: World J Gastroenterol Source Type: research

A pilot prospective study to evaluate whether the bladder morphology in cystography and/or urodynamic may help predict the response to botulinum toxin a injection in neurogenic bladder refractory to anticholinergics
Conclusions: This study suggests that the cystography parameters evaluated cannot be used to help predict the response to injection of BTX-A in the treatment of refractory NDO. However, the urodynamic parameters were significantly different in patients who responded to the treatment, with the exception of the MDP. (Source: BMC Urology - Latest articles)
Source: BMC Urology - Latest articles - August 14, 2014 Category: Urology & Nephrology Authors: Ronaldo ÁlvaresIvana AraújoMarcelo Sanches Source Type: research

Sex Differences and Attitudes toward Living Donor Kidney Transplantation among Urban Black Patients on Hemodialysis.
CONCLUSIONS: In contrast to previous studies, the study found that black women were less likely to want living donor kidney transplantation compared with black men. Black women were also less likely to be evaluated for a kidney transplant, although they were more likely to receive an unsolicited living donor kidney transplantation offer. PMID: 25125384 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - August 14, 2014 Category: Urology & Nephrology Authors: Gillespie A, Hammer H, Kolenikov S, Polychronopoulou A, Ouzienko V, Obradovic Z, Urbanski MA, Browne T, Silva P Tags: Clin J Am Soc Nephrol Source Type: research

Can we expand active surveillance criteria to include biopsy Gleason 3+4 prostate cancer? A multi-institutional study of 2,323 patients.
CONCLUSIONS: Approximately half of patients with biopsy Gleason score 3+4 cancer have unfavorable disease at final pathology. Nevertheless, expanding AS eligibility to these patients may be acceptable provided adherence to strict selection criteria leading to a<20% risk of unfavorable disease. Future tools for selection such as magnetic resonance imaging, early rebiopsy, and serum markers may be especially beneficial in this group of patients. PMID: 25131660 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - August 14, 2014 Category: Urology & Nephrology Authors: Ploussard G, Isbarn H, Briganti A, Sooriakumaran P, Surcel CI, Salomon L, Freschi M, Mirvald C, van der Poel HG, Jenkins A, Ost P, van Oort IM, Yossepowitch O, Giannarini G, van den Bergh RC, Members of the Prostate Cancer Working Group of the Young Acade Tags: Urol Oncol Source Type: research

MALDI imaging-based identification of prognostically relevant signals in bladder cancer using large-scale tissue microarrays.
CONCLUSION: Our data demonstrate the suitability of combining MSI and large-scale tissue microarrays to simultaneously identify and validate clinically useful molecular markers in urinary bladder cancer. PMID: 25131659 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - August 14, 2014 Category: Urology & Nephrology Authors: Steurer S, Singer JM, Rink M, Chun F, Dahlem R, Simon R, Burandt E, Stahl P, Terracciano L, Schlomm T, Wagner W, Höppner W, Omidi M, Kraus O, Kwiatkowski M, Doh O, Fisch M, Soave A, Sauter G, Wurlitzer M, Schlüter H, Minner S Tags: Urol Oncol Source Type: research

LOX-1 - dependent mitochondrial DNA damage and NLRP3 activation during systemic inflammation in mice.
CONCLUSIONS: These in vivo observations indicate that LOX-1 plays a key role in mtDNA damage which then leads to NLRP3 inflammasome activation during inflammation. PMID: 25130466 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - August 14, 2014 Category: Biochemistry Authors: Ding Z, Liu S, Wang X, Theus S, Fan Y, Deng X, Mehta JL Tags: Biochem Biophys Res Commun Source Type: research

Cholesterol efflux from THP-1 macrophages is impaired by the fatty acid component from lipoprotein hydrolysis by lipoprotein lipase.
Abstract Lipoprotein lipase (LPL) is an extracellular lipase that primarily hydrolyzes triglycerides within circulating lipoproteins. Macrophage LPL contributes to atherogenesis, but the mechanisms behind it are poorly understood. We hypothesized that the products of lipoprotein hydrolysis generated by LPL promote atherogenesis by inhibiting the cholesterol efflux ability by macrophages. To test this hypothesis, we treated human THP-1 macrophages with total lipoproteins that were hydrolysed by LPL and we found significantly reduced transcript levels for the cholesterol transporters ATP binding cassette transporter ...
Source: Biochemical and Biophysical Research communications - August 14, 2014 Category: Biochemistry Authors: Yang Y, Thyagarajan N, Coady BM, Brown RJ Tags: Biochem Biophys Res Commun Source Type: research

Defining the biology component of the drug discovery strategy for malaria eradication.
Abstract Malaria is still considered a deadly scourge in Africa, Asia, and South America despite improved vector control and curative treatments with new antimalarial combinations. The next challenge is to work towards disease eradication. To achieve this goal it is crucial to develop, validate, and integrate biological assays into test cascades that align with the key target product profiles. For anti-relapse, a parent molecule should kill hypnozoites or cause activation of Plasmodium vivax liver stages. For transmission blocking, dual equal-activity antimalarials killing both the asexual and the sexual parasite s...
Source: Trends in Parasitology - August 14, 2014 Category: Parasitology Authors: Leroy D, Campo B, Ding X, Jeremy, Burrows N, Cherbuin S Tags: Trends Parasitol Source Type: research

Carbohydrate Malabsorption Mechanism for Tumor Formation in Rats Treated with the SGLT2 Inhibitor Canagliflozin.
Abstract Canagliflozin is an SGLT2 inhibitor used for the treatment of type 2 diabetes mellitus. Studies were conducted to investigate the mechanism responsible for renal tubular tumors and pheochromocytomas observed at the high dose in a 2-year carcinogenicity study in rats. At the high dose (100 mg/kg) in rats, canagliflozin caused carbohydrate malabsorption evidenced by inhibition of intestinal glucose uptake, decreased intestinal pH and increased urinary calcium excretion. In a 6-month mechanistic study utilization of a glucose-free diet prevented carbohydrate malabsorption and its sequelae, including increased...
Source: Chemico-Biological Interactions - August 14, 2014 Category: Molecular Biology Authors: Mamidi RN, Proctor J, Jonghe SD, Feyen B, Moesen E, Vinken P, Ma JY, Bryant S, Snook S, Louden C, Lammens G, Ways K, Kelley MF, Johnson MD Tags: Chem Biol Interact Source Type: research

Kidney Stones: New Tool May Predict RecurrenceKidney Stones: New Tool May Predict Recurrence
Knowing which patients are most at risk could help physicians focus recommendations for medications, tests, and diet. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 13, 2014 Category: Consumer Health News Tags: Nephrology News Source Type: news

Effect of Mitomycin, Bevacizumab, and 5-Fluorouracil to Inhibit Urethral Fibrosis in a Rabbit Model
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology)
Source: Journal of Endourology - August 13, 2014 Category: Urology & Nephrology Tags: article Source Type: research

The Impact of Hospital Volume on Postoperative Complications Following Robot-Assisted Partial Nephrectomy
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology)
Source: Journal of Endourology - August 13, 2014 Category: Urology & Nephrology Tags: article Source Type: research

Endoscopic Guided Additional Access for Staghorn Calculi
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology)
Source: Journal of Endourology - August 13, 2014 Category: Urology & Nephrology Tags: article Source Type: research

Editorial Comment for Sim et al.
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology)
Source: Journal of Endourology - August 13, 2014 Category: Urology & Nephrology Tags: article Source Type: research

With advances in HIV care, survivors face other disease risks
As effective treatments for HIV become more widely available in low- and middle-income countries, there's an urgent need to assess and manage health risks in the growing number of people living with HIV. "Today, with over 35 million people living (and aging) with HIV and over two million becoming infected every year, we are faced with a new challenge: addressing morbidity and mortality -- heart disease, stroke, diabetes and metabolic complications, renal disease, cancers, liver disease, and mental illness," authors write. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 13, 2014 Category: Science Source Type: news

Diabetic Nephropathy Linked to Hypothyroidism (Renal and Urology News, 11 August)
Subclinical hypothyroidism (SCH) may be independently associated with diabetic nephrophathy with diabetes mellitus according to a Japanese study which will be published in the Endorcrine Journal. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - August 13, 2014 Category: Endocrinology Source Type: news

Diabetic Nephropathy Linked to Hypothyroidism (Renal and Urology News, 11 August 2014)
Subclinical hypothyroidism (SCH) may be independently associated with diabetic nephrophathy with diabetes mellitus according to a Japanese study which will be published in the Endorcrine Journal. Full article (Source: Society for Endocrinology)
Source: Society for Endocrinology - August 13, 2014 Category: Endocrinology Source Type: news

Salt injections: not a cure for cancer
Conclusion This is an early phase in the development of new drugs to combat cancer, and it should be stressed that these experiments did not involve humans or injecting cancer with salt. There is no new treatment for cancer using salt. This research has, however, shed light on how increasing the salt level in cells can trigger the activation of one of the cell’s pathways for causing cell death. Two different molecules were developed that transported chloride. The increased amount of chloride within the cells caused more sodium to enter. This caused cell death in a variety of different types of cancer cells in the lab, in...
Source: NHS News Feed - August 13, 2014 Category: Consumer Health News Tags: Cancer Source Type: news

Challenges for paediatric transplantation in Africa
Abstract Transplantation is the accepted mode of treatment for patients with end‐stage organ disease affecting the heart, lungs, kidney, pancreas, liver and intestine. Long‐term outcomes have significantly improved and the aim of management is no longer only long‐term survival, but also focuses on quality of life especially in children. Transplantation in Africa faces a number of challenges including wide socioeconomic disparity, lack of legislation around brain death and organ donation in many countries, shortage of skilled medical personnel and facilities, infectious disease burden and insecure access to and monito...
Source: Pediatric Transplantation - August 13, 2014 Category: Transplant Surgery Authors: C. W. N. Spearman, M. I. McCulloch Tags: Review Article Source Type: research

Prevalence and Factors Associated With Resistant Hypertension in a Large Health Maintenance Organization in Israel [Epidemiology/Population]
Previous assessments of the prevalence of resistant hypertension (RH) in uncontrolled blood pressure (BP) have ranged from 3% to 30%. Using real-world data, our aim was to estimate the prevalence of RH in patients belonging to the Maccabi Healthcare Services, a 2-million-member health organization in Israel. From 2010 to 2011, all hypertensive patients with ≥2 recorded BP measurements during a minimum period of 6 months were identified. Patients were considered uncontrolled if their most recent BP during the study period and their mean systolic BP or diastolic BP during a preceding period of ≥6months were systolic BP...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Weitzman, D., Chodick, G., Shalev, V., Grossman, C., Grossman, E. Tags: Other hypertension Epidemiology/Population Source Type: research

HV1 Acts as a Sodium Sensor and Promotes Superoxide Production in Medullary Thick Ascending Limb of Dahl Salt-Sensitive Rats [Kidney]
We previously characterized a H+ transport pathway in medullary thick ascending limb nephron segments that when activated stimulated the production of superoxide by nicotinamide adenine dinucleotide phosphate oxidase. Importantly, the activity of this pathway was greater in Dahl salt-sensitive rats than salt-resistant (SS.13BN) rats, and superoxide production was enhanced in low Na+ media. The goal of this study was to determine the molecular identity of this pathway and its relationship to Na+. We hypothesized that the voltage-gated proton channel, HV1, was the source of superoxide-stimulating H+ currents. To test this hy...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Jin, C., Sun, J., Stilphen, C. A., Smith, S. M. E., Ocasio, H., Bermingham, B., Darji, S., Guha, A., Patel, R., Geurts, A. M., Jacob, H. J., Lambert, N. A., O'Connor, P. M. Tags: Other hypertension Kidney Source Type: research

Prostaglandin I2 and Prostaglandin E2 Modulate Human Intrarenal Artery Contractility Through Prostaglandin E2-EP4, Prostacyclin-IP, and Thromboxane A2-TP Receptors [Kidney]
In conclusion, PGE2 and PGI2 may protect renal perfusion by activating cognate IP and EP4 receptors associated with smooth muscle cells and endothelium in human intrarenal arteries and contribute to increased renal vascular resistance at high pathological concentrations mediated by noncognate TP receptor. (Source: Hypertension)
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Eskildsen, M. P., Hansen, P. B. L., Stubbe, J., Toft, A., Walter, S., Marcussen, N., Rasmussen, L. M., Vanhoutte, P. M., Jensen, B. L. Tags: Cardio-renal physiology/pathophysiology, Platelets, Endothelium/vascular type/nitric oxide Kidney Source Type: research

Female Spontaneously Hypertensive Rats Have a Compensatory Increase in Renal Regulatory T Cells in Response to Elevations in Blood Pressure [Kidney]
In conclusion, BP contributes to sex differences in the renal T-cell profile of SHR; female SHR increase renal Tregs in response to increases in BP. (Source: Hypertension)
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Tipton, A. J., Baban, B., Sullivan, J. C. Tags: Other hypertension Kidney Source Type: research

Sex-Specific T-Cell Regulation of Angiotensin II-Dependent Hypertension [Renin-Angiotensin System]
Studies suggest T cells modulate arterial pressure. Because robust sex differences exist in the immune system and in hypertension, we investigated sex differences in T-cell modulation of angiotensin II–induced increases in mean arterial pressure in male (M) and female (F) wild-type and recombination-activating-gene-1–deficient (Rag1–/–) mice. Sex differences in peak mean arterial pressure in wild-type were lost in Rag1–/– mice (mm Hg: wild-type-F, 136±4.9 versus wild-type-M, 153±1.7; P<0.02; Rag1–/–-F, 135±2.1 versus Rag1–/–-M, 141±3...
Source: Hypertension - August 13, 2014 Category: Cardiology Authors: Ji, H., Zheng, W., Li, X., Liu, J., Wu, X., Zhang, M. A., Umans, J. G., Hay, M., Speth, R. C., Dunn, S. E., Sandberg, K. Tags: Animal models of human disease, Other hypertension Renin-Angiotensin System Source Type: research

TRAIL expression levels in human HCC have implications for tumor growth, recurrence, and survival
Abstract The proapoptotic molecule TNF‐related apoptosis‐inducing ligand (TRAIL) has earned attention because of its ability to induce apoptosis in liver cancer cells without damaging normal liver cells. It may play an important role in preventing the development and outgrowth of hepatocellular carcinoma (HCC). TRAIL expression was investigated in a large series of human HCCs. We analyzed liver tissue from 108 patients undergoing partial liver resection (PRT) or liver transplantation (LT) because of either HCC or other indications. TRAIL expression was correlated with the cause of liver disease, demographic and clinica...
Source: International Journal of Cancer - August 13, 2014 Category: Cancer & Oncology Authors: Katja Piras‐Straub, Khaleda Khairzada, Martin Trippler, Hideo A. Baba, Gernot M. Kaiser, Andreas Paul, Ali Canbay, Frank Weber, Guido Gerken, Kerstin Herzer Tags: Epidemiology Source Type: research

Targeting AR to Suppress Kidney Cancer Progression
Males have a higher incidence of renal cell carcinoma (RCC) than females, but the reason for this gender difference is unknown. Addressing this question, we report the discovery of an androgen receptor (AR)–induced HIF2α/VEGF signal that drives RCC progression. AR attenuation or augmentation in RCC cells altered their proliferation, migration, and invasion in multiple models in vitro and in vivo. Mechanistic investigations revealed that AR targeting inhibited RCC cell migration and invasion by modulating HIF2α/VEGF signals at the level of mRNA and protein expression. Interrupting HIF2α/VEGF signals with inhibitors of ...
Source: Cancer Research - August 13, 2014 Category: Cancer & Oncology Authors: He, D., Li, L., Zhu, G., Liang, L., Guan, Z., Chang, L., Chen, Y., Yeh, S., Chang, C. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

Liver Cancer Genetic Model
Hepatocellular carcinoma (HCC) was thought historically to arise from hepatocytes, but gene expression studies have suggested that it can also arise from fetal progenitor cells or their adult progenitor progeny. Here, we report the identification of a unique population of fetal liver progenitor cells in mice that can serve as a cell of origin in HCC development. In the transgenic model used, mice carry the Cited1-CreERTM-GFP BAC transgene in which a tamoxifen-inducible Cre (CreERTM) and GFP are controlled by a 190-kb 5′ genomic region of Cited1, a transcriptional coactivator protein for CBP/p300. Wnt signaling is critica...
Source: Cancer Research - August 13, 2014 Category: Cancer & Oncology Authors: Mokkapati, S., Niopek, K., Huang, L., Cunniff, K. J., Ruteshouser, E. C., deCaestecker, M., Finegold, M. J., Huff, V. Tags: Tumor and Stem Cell Biology Source Type: research

Diabetes: How do I help protect my liver?
(Source: MayoClinic.com - Ask a Specialist)
Source: MayoClinic.com - Ask a Specialist - August 13, 2014 Category: Consumer Health News Source Type: news

Undifferentiated Sarcoma of the Liver: A Case Study of an Erythropoietin-Secreting Tumor
We present a case of a 53-year-old woman with an undifferentiated sarcoma of the liver (USL), which resembles UESL, who initially presented with a markedly elevated hematocrit (61.2%). Cytogenetic studies for polycythemia vera were negative, but the patient’s erythropoietin (EPO) was elevated. A computed tomography scan and subsequent partial hepatectomy revealed a well-circumscribed, partially cystic mass in the right lobe of the liver measuring 34 cm. Following surgery, the patient’s EPO level and hematocrit dropped to within normal range and remained so for 1 year, at which point it rose again. A subsequent ...
Source: International Journal of Surgical Pathology - August 13, 2014 Category: Pathology Authors: Lin, J. M., Heath, J. E., Twaddell, W. S., Castellani, R. J. Tags: Case Reports Source Type: research

Complete response of sunitinib therapy for renal cell cancer recurrence in the native kidney after renal transplantation: a case report
Conclusions: This study presented the case of sunitinib therapy for renal cancer in the native kidney after renal transplantation. The therapeutic efficacy and safety for such cases should be discussed. (Source: BMC Research Notes)
Source: BMC Research Notes - August 13, 2014 Category: Research Authors: Fumiya HongoMasakatsu OishiTakashi UedaYasuyuki NaitohTerukazu NakamuraYoshio NayaKazumi KamoiKoji OkiharaTsuneharu Miki Source Type: research

Targets for parathyroid hormone in secondary hyperparathyroidism: is a "one-size-fits-all" approach appropriate? A prospective incident cohort study
Conclusion: In real life, dialysis patients with newly diagnosed SHPT constitute a very heterogeneous population. A "one-size-fits-all" target approach is probably not appropriate. Therapeutic management needs to be adjusted to the 4 different phenotypes. (Source: BMC Nephrology)
Source: BMC Nephrology - August 13, 2014 Category: Urology & Nephrology Authors: Emmanuelle LaurainCarole AyavMarie-Line ErpeldingMichèle KesslerSerge BriançonLaurent BrunaudLuc Frimat Source Type: research

Health‐related quality of life from a prospective randomised clinical trial of robot‐assisted laparoscopic vs open radical cystectomy
ConclusionsThere were no significant differences in the HRQoL outcomes between ORC and RARC, with a return of quality of life scores to baseline scores 3 months after radical cystectomy in both cohorts. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Jamie C. Messer, Sanoj Punnen, John Fitzgerald, Robert Svatek, Dipen J. Parekh Tags: Robotics and Laparoscopy Source Type: research

Exploring the evidence for early unclamping during robot‐assisted partial nephrectomy: is it worth the time and effort?
(Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Oliver Cawley, Alexandrina Roman, Matthew Brown, Ben Challacombe Tags: Comment Source Type: research

Baseline characteristics predict risk of progression and response to combined medical therapy for benign prostatic hyperplasia (BPH)
ConclusionsUsing baseline factors permits estimation of individual patient risk for clinical progression and the benefits of medical therapy. A novel clinical decision tool based on these analyses will allow clinicians to weigh patient‐specific benefits against possible risks of adverse effects for a given patient. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Michael A. Kozminski, John T. Wei, Jason Nelson, David M. Kent Tags: Functional Urology Source Type: research

Early unclamping technique during robot‐assisted laparoscopic partial nephrectomy can minimise warm ischaemia without increasing morbidity
ConclusionsEUC can reduce WIT during RAPN without increasing morbidity even for complex renal tumours or when being performed by less experienced surgeons. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Benoit Peyronnet, Hervé Baumert, Romain Mathieu, Alexandra Masson‐Lecomte, Yohann Grassano, Mathieu Roumiguié, Walid Massoud, Vincent Abd El Fattah, Franck Bruyère, Stéphane Droupy, Alexandre Taille, Nicolas Doumerc, Jean‐Christophe Bernhard, Chri Tags: Robotics and Laparoscopy Source Type: research

Propensity‐score matched analysis comparing robot‐assisted with laparoscopic partial nephrectomy
ConclusionsAfter adjusting for potential treatment selection biases, RAPN was found to be superior to LPN for peri‐operative outcomes (EBL, WIT and intra‐operative complications) and early renal functional preservation. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Zhenjie Wu, Mingmin Li, Shangqing Song, Huamao Ye, Qing Yang, Bing Liu, Chen Cai, Bo Yang, Liang Xiao, Qi Chen, Chen Lü, Xu Gao, Chuanliang Xu, Xiaofeng Gao, Jianguo Hou, Linhui Wang, Yinghao Sun Tags: Robotics and Laparoscopy Source Type: research

Differences in 24‐h urine composition between nephrolithiasis patients with and without diabetes mellitus
ConclusionsDM was associated with multiple differences on 24‐h urine analysis compared with those without DM, including significantly higher UA and oxalate, and lower pH. Control of urinary UA and pH, as well as limiting intake of dietary oxalate may reduce stone formation in patients with DM. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Christopher Hartman, Justin I. Friedlander, Daniel M. Moreira, Sammy E. Elsamra, Arthur D. Smith, Zeph Okeke Tags: Upper Urinary Tract Source Type: research

External validation of the Briganti nomogram to estimate the probability of specimen‐confined disease in patients with high‐risk prostate cancer
ConclusionsThis external validation of the Briganti nomogram shows relevant accuracy, although the relative imprecision for intermediate risk may limit its clinical relevance. Our follow‐up findings confirm the large proportion of specimen‐confined PCa with good oncological outcomes in this heterogeneous subgroup of patients with high‐risk PCa. (Source: BJU International)
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Mathieu Roumiguié, Jean‐Baptiste Beauval, Thomas Filleron, Thibaut Benoit, Pascal Rischmann, Alexandre Taille, Laurent Salomon, Michel Soulié, Bernard Malavaud, Guillaume Ploussard Tags: Urological Oncology Source Type: research

Is radical nephrectomy a legitimate therapeutic option in patients with renal masses amenable to nephron‐sparing surgery?
The decision to perform a radical nephrectomy (RN) or a partial nephrectomy (PN), not unlike most decisions in clinical practice, ultimately hinges on the balance of risk. Do the higher risks of a more complex surgery (PN) justify the theoretical benefits of kidney tissue preservation? Data suggest that for patients with an anatomically complex renal mass and a normal contralateral kidney, for whom additional surgical intensity may be risky, such as the elderly and comorbid, RN presents a robust treatment option. Nevertheless, PN, especially for small and anatomically simple renal masses in young patients without comorbidi...
Source: BJU International - August 13, 2014 Category: Urology & Nephrology Authors: Jeffrey J. Tomaszewski, Marc C. Smaldone, Robert G. Uzzo, Alexander Kutikov Tags: Review Source Type: research