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Urology & Nephrology

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Hemodialysis and Bariatric Surgery: A Guide for Adequate Protein Intake
Over the past decade, the number of obese and morbidly obese kidney transplant recipients has been on the rise. In the 90's, less than 20% of all transplant patients had a body mass index (BMI) that was greater than 30 kg/m2. More recently, however, 23% of all transplant recipients were considered obese with a BMI of 30 kg/m2 or greater, and 11.5% were considered either morbidly obese or very morbidly obese (BMI > 35 kg/m2).1 At present, a BMI of less than 35 kg/m2 is the most commonly used selection criterion in renal transplant centers and an increasing number of patients with end-stage renal disease (ESRD) are being...
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Authors: Elaine McCall, Crystal Hazzard Tags: Patient Education Source Type: research

September Meeting Announcements
September 7-10, 2014 The International Society for Peritoneal Dialysis (ISPD) -15th Congress 2014, Madrid, Spain. Visit www.ispdmadrid2014.com or call +34 91 361 2600. (Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Tags: Announcements Source Type: research

Affordable Protein Foods for Dialysis Patients
As if the diet for most dialysis patients is not challenging enough, financial constraints make it more difficult. The reality is that many dialysis patients struggle to afford the foods renal dietitians recommend. One contributing factor is the high protein requirements of dialysis patients with the high cost of better quality protein foods.1 Better quality protein, such as leaner cuts of meat, costs more. And although they are gaining acceptance in the dialysis diet now, cheaper vegetable proteins such as beans and nuts have not been strongly recommended in the past because of their lower biological protein value and pho...
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Authors: Julie Hulsebus Tags: Product Update Source Type: research

Editorial Board
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Source Type: research

Masthead
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Source Type: research

Table of Contents
(Source: Journal of Renal Nutrition)
Source: Journal of Renal Nutrition - August 25, 2014 Category: Urology & Nephrology Source Type: research

Our patients’ stories: From patient to advocate
Rachael Adler is not the kind of person who stands around waiting for life to happen. At 13, she’s a good student who participates in many school and community service events. And despite her young age, she’s been a key speaker at events held by both The New York Alliance for Donation (NYAD) and the Northeast Kidney Foundation. But Rachael didn’t get to be the strong, active young person she is today without overcoming adversity first—and overcoming that adversity is playing a big role in helping shape the person she wants to become. “A complete surprise” Rachael was a very healthy and activ...
Source: Thrive, Children's Hospital Boston - August 25, 2014 Category: Pediatrics Authors: Tripp Underwood Tags: All posts kidney transplant our patients' stories Pediatric Transplant Center (PTC) Source Type: news

Keyhold surgery for cancer spread to liver
New surgical methods give hope to patients with cancer that has spread from the intestine to the liver. The disease can be changed from terminal to chronic by cutting the liver piece by piece using keyhole surgery. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 25, 2014 Category: Science Source Type: news

Academy of Nutrition and Dietetics and National Kidney Foundation: Revised 2014 Standards of Practice and Standards of Professional Performance for Registered Dietitian Nutritionists (Competent, Proficient, and Expert) in Nephrology Nutrition
Compelling evidence indicates that the incidence of chronic kidney disease (CKD) is increasing because of an aging population and a higher prevalence of cardiovascular disease, diabetes, and hypertension. Nutrition management of patients with CKD requires early disease recognition, appropriate interpretation of the markers and stages of CKD, and collaboration with other health care practitioners. Better management of CKD can slow its progression, prevent metabolic complications, and reduce cardiovascular related outcomes. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - August 25, 2014 Category: Nutrition Authors: Pamela S. Kent, Maureen P. McCarthy, Jerrilynn D. Burrowes, Linda McCann, Jessie Pavlinac, Catherine M. Goeddeke-Merickel, Karen Wiesen, Sarah Kruger, Laura Byham-Gray, Rory C. Pace, Valarie Hannahs, Debbie Benner Tags: Standards of Practice & Professional Performance Source Type: research

Is Medical Nutrition Therapy Appropriate for Kidney Stones?
Stones that form in the kidneys (nephrolithiasis) or in the urinary tract (urolithiasis) have been increasing in prevalence.1-6 Kidney stones can vary in their size, shape, location, and type, (ie, calcium, uric acid, struvite, and cystine).7 Most calcium stones are comprised of either oxalate or phosphate, with calcium oxalate stones being the most common.1-4,7,8 Knowing the type of kidney stone is essential in terms of its treatment and prevention,1-2 especially considering the high recurrence rate. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - August 25, 2014 Category: Nutrition Authors: Jill Balla Kohn Tags: Question of the Month Source Type: research

Outcomes of Patients After Liver TransplantationOutcomes of Patients After Liver Transplantation
Patients with hepatopulmonary syndrome are often given priority for liver transplants based on a certain MELD score. How do these patients generally fare after the transplant? Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 25, 2014 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Conclusion to 80 Year Old Male: Fall
Conclusion In this case the patient received IV hydromorphone for his pain, was admitted for pacemaker placement the next day, and received his new hip soon after that. He experienced no lingering complications from his stay except for slightly decreased renal function and was discharged to rehab in good condition.   (Source: EMS 12-Lead)
Source: EMS 12-Lead - August 25, 2014 Category: Cardiology Authors: Vince DiGiulio Tags: Arrhythmia Cases Conclusion arrhythmias AV Block bifascicular block LAFB left atrial abnormality Mobitz II RBBB Syncope type II Vince DiGiulio Source Type: research

Suppressing the CDC37 cochaperone in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth
ConclusionsOn the basis of the observed antitumour effects of inhibiting CDC37 expression, we propose that CDC37 is a promising therapeutic target in HCC. Its ability to regulate multiple pathways makes it potentially valuable in treating the heterogeneous subtypes of this malignancy. (Source: Liver International)
Source: Liver International - August 25, 2014 Category: Gastroenterology Authors: Zhanhui Wang, Wei Wei, Chris K. Sun, Mei‐Sze Chua, Samuel So Tags: Original Article Source Type: research

The Role of Minority Geographic Distribution in Waiting Time for Deceased Donor Kidney Transplantation
In the US, African Americans and other minority groups have longer wait times to deceased donor kidney transplantation than Caucasians. To date, the role of geographic distribution of racial and ethnic groups as a determinant of wait times has not been fully elucidated. Using the Scientific Registry of Transplant Recipients database, all registrants for kidney transplant between 2004 and 2007 (n = 126 094) were analyzed from time of waitlisting until nonzero antigen mismatched deceased donor kidney transplant. Nationally, deceased donor transplantation occurred at a lower rate for African Americans (hazard ratio [HR]...
Source: American Journal of Transplantation - August 25, 2014 Category: Transplant Surgery Authors: G. M. Vranic, J. Z. Ma, D. S. Keith Tags: Original Article Source Type: research

Hepatic Syndecan‐1 Changes Associate With Dyslipidemia After Renal Transplantation
Syndecan‐1 is a transmembrane heparan sulfate (HS) proteoglycan present on hepatocytes and involved in uptake of triglyceride‐rich lipoproteins via its HS polysaccharide side chains. We hypothesized that altered hepatic syndecan‐1 metabolism could be involved in dyslipidemia related to renal transplantation. In a rat renal transplantation model elevated plasma triglycerides were associated with fivefold increased expression of hepatic syndecan‐1 mRNA (p < 0.01), but not protein. Expression of syndecan‐1 sheddases (ADAM17, MMP9) and heparanase was significantly up‐regulated after renal transplantation (al...
Source: American Journal of Transplantation - August 25, 2014 Category: Transplant Surgery Authors: S. Adepu, K. Katta, U. J. F. Tietge, A. J. Kwakernaak, W. Dam, H. van Goor, R. P. F. Dullaart, G. J. Navis, S. J. L. Bakker, J. van den Born Tags: Original Article Source Type: research

The Kidney Donor Profile Index (KDPI) of Marginal Donors Allocated by Standardized Pretransplant Donor Biopsy Assessment: Distribution and Association With Graft Outcomes
In conclusion, PTDB‐based allocation allows the safe transplantation of kidneys with KDPI in the highest range that may otherwise be discarded. (Source: American Journal of Transplantation)
Source: American Journal of Transplantation - August 25, 2014 Category: Transplant Surgery Authors: I. Gandolfini, C. Buzio, P. Zanelli, A. Palmisano, E. Cremaschi, A. Vaglio, G. Piotti, L. Melfa, G. La Manna, G. Feliciangeli, M. Cappuccilli, M. P. Scolari, I. Capelli, L. Panicali, O. Baraldi, S. Stefoni, A. Buscaroli, L. Ridolfi, A. D'Errico, G. Cappel Tags: Original Article Source Type: research

Perioperative changes of procalcitonin levels in patients undergoing liver transplantation
ConclusionSerum PCT measurement, using appropriate cutoff values, could help diagnose severe infection, and might be able to differentiate bacteremia from acute cellular rejection. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - August 25, 2014 Category: Transplant Surgery Authors: T. Kaido, K. Ogawa, Y. Fujimoto, A. Mori, E. Hatano, H. Okajima, S. Uemoto Tags: Original Report Source Type: research

Hepatic encephalopathy is associated with significantly increased mortality among patients awaiting liver transplantation
In conclusion, grade 3‐4 HE at time of waitlist registration significantly increases 90‐day waitlist mortality independent of MELD score. Incorporating HE in the assessment of LT priority may improve prognostication of liver disease severity and prioritization for LT. Liver Transpl , 2014. © 2014 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - August 25, 2014 Category: Transplant Surgery Authors: Robert J. Wong, Robert G. Gish, Aijaz Ahmed Tags: Original Article Source Type: research

Alpha‐fetoprotein level > 1000 ng/mL as an exclusion criteria for liver transplantation in patients with hepatocellular carcinoma meeting the milan criteria
(Source: Liver Transplantation)
Source: Liver Transplantation - August 25, 2014 Category: Transplant Surgery Authors: Francis Y. Yao, Bilal Hameed, Neil Mehta, John P. Roberts Tags: Letter to the Editor Source Type: research

Obesity and liver transplantation/liver resection
(Source: Liver Transplantation)
Source: Liver Transplantation - August 25, 2014 Category: Transplant Surgery Authors: Julie Heimbach Tags: ILTS course syllabus Source Type: research

The development of autoimmune features in aging mice is closely associated with alterations of the peripheral CD4+ T‐cell compartment
Some signs of potential autoimmunity, such as the appearance of antinuclear antibodies (ANAs) become prevalent with age. In most cases, elderly people with ANAs remain healthy. Here, we investigated whether the same holds true for inbred strains of mice. Indeed, we show that most mice of the C57BL/6 (B6) strain spontaneously produced IgG ANA at 8–12 months of age, showed IgM deposition in kidneys and lymphocyte infiltrates in submandibular salivary glands. Despite all of this, the mice remained healthy. ANA production is likely CD4+ T‐cell dependent, since old (40–50 weeks of age) B6 mice deficient for MHC class II d...
Source: European Journal of Immunology - August 25, 2014 Category: Allergy & Immunology Authors: Anja Nusser, Natko Nuber, Oliver F. Wirz, Hannie Rolink, Jan Andersson, Antonius Rolink Tags: Regular Article Source Type: research

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle
Conclusions This proof-of-principle study is one of the first to demonstrate that high-depth targeted MPS of plasma-derived ctDNA constitutes a potential tool for de novo mutation identification and monitoring of somatic genetic alterations during the course of targeted therapy, and may be employed to overcome the challenges posed by intra-tumor genetic heterogeneity. Registered clinical trial www.clinicaltrials.gov, NCT01090960. (Source: Annals of Oncology)
Source: Annals of Oncology - August 25, 2014 Category: Cancer & Oncology Authors: De Mattos-Arruda, L., Weigelt, B., Cortes, J., Won, H. H., Ng, C. K. Y., Nuciforo, P., Bidard, F.- C., Aura, C., Saura, C., Peg, V., Piscuoglio, S., Oliveira, M., Smolders, Y., Patel, P., Norton, L., Tabernero, J., Berger, M. F., Seoane, J., Reis-Filho, J Tags: original articles Source Type: research

Final results of a multicenter phase II study of the purine nucleoside phosphorylase (PNP) inhibitor forodesine in patients with advanced cutaneous t-cell lymphomas (CTCL) (Mycosis fungoides and Sezary syndrome)
Conclusion Oral forodesine at a dose of 200 mg daily is feasible and shows partial efficacy in this highly selected CTCL population and some durable responses. (Source: Annals of Oncology)
Source: Annals of Oncology - August 25, 2014 Category: Cancer & Oncology Authors: Dummer, R., Duvic, M., Scarisbrick, J., Olsen, E. A., Rozati, S., Eggmann, N., Goldinger, S. M., Hutchinson, K., Geskin, L., Illidge, T. M., Giuliano, E., Elder, J., Kim, Y. H. Tags: original articles Source Type: research

Individualized Prostate-specific Antigen Threshold Values to Avoid Overdiagnosis of Prostate Cancer and Reduce Unnecessary Biopsy in Elderly Men
Conclusions These individualized prostate-specific antigen threshold values may be useful for determining an indication of prostate biopsy for elderly men to avoid overdiagnosis of prostate cancer and reduce unnecessary biopsy. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 25, 2014 Category: Cancer & Oncology Authors: Kanao, K., Komori, O., Nakashima, J., Ohigashi, T., Kikuchi, E., Miyajima, A., Nakagawa, K., Eguchi, S., Oya, M. Tags: Urology, Original Articles Source Type: research

The Oncological Outcomes and Risk Stratification in Docetaxel Chemotherapy for Castration-resistant Prostate Cancer
Conclusions Oncologic outcomes in Japanese patients with castration-resistant prostate cancer receiving docetaxel chemotherapy were comparable to or slightly better than those in Western populations, and the risk-stratification model developed in this study may help to predict prognosis and contribute to the selection of suitable therapy after castration resistance. (Source: Japanese Journal of Clinical Oncology)
Source: Japanese Journal of Clinical Oncology - August 25, 2014 Category: Cancer & Oncology Authors: Shiota, M., Yokomizo, A., Adachi, T., Koga, H., Yamaguchi, A., Imada, K., Takeuchi, A., Kiyoshima, K., Inokuchi, J., Tatsugami, K., Naito, S. Tags: Urology, Original Articles Source Type: research

Fulminant Hepatitis Following Crizotinib Administration for ALK-positive Non-small-cell Lung Carcinoma
We herein report a case of fatal fulminant hepatitis secondary to crizotinib administration. The patient was 54-year-old female with a history of Hepatitis C infection (not current), dermatomyositis and steroid-induced diabetes mellitus. She was diagnosed with advanced lung adenocarcinoma with anaplastic lymphoma kinase rearrangement. We began 400 mg of crizotinib as first-line therapy. No adverse effects were seen until Day 16. On Day 29, she was admitted to hospital with elevated liver enzymes (aspartate aminotransferase 3236 IU/l, alanine aminotransferase 5201 IU/l) and coagulopathy (prothrombin time <10%), and was d...
Source: Japanese Journal of Clinical Oncology - August 25, 2014 Category: Cancer & Oncology Authors: Sato, Y., Fujimoto, D., Shibata, Y., Seo, R., Suginoshita, Y., Imai, Y., Tomii, K. Tags: Case Report Case Reports Source Type: research

KRAS mutation in patients undergoing hepatic resection for colorectal liver metastasis: A biomarker of cancer biology or a byproduct of patient selection?
Patients with colorectal cancer have experienced remarkable progress in a range of surgical and oncologic management strategies over the past few years, with a corresponding improvement in survival. The KRAS mutation may be a biomarker of cancer biology and prognosis, but also reflects patient selection. (Source: Cancer)
Source: Cancer - August 25, 2014 Category: Cancer & Oncology Authors: Kjetil Søreide, Oddvar M. Sandvik, Jon A. Søreide Tags: Editorial Source Type: research

Hepatology: Images of hydatid cyst of the liver mimicking an hepatic abscess
(Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 25, 2014 Category: Gastroenterology Authors: H Jerraya, W Bouchaala, D Chadli Tags: Education and Imaging Source Type: research

Advanced liver fibrosis by transient elastography, Fibrosis 4, and alanine aminotransferase/platelet ratio index among Asian hepatitis C with and without human immunodeficiency virus infection: Role of vitamin D levels
ConclusionsHIV infection, Fib‐4 score > 1.45, and hypovitaminosis D are strong and independent predictors for the presence of advanced fibrosis in our HCV‐infected patients. These data highlight the urgent need of HCV treatment and vitamin D supplement in resource‐limited settings. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 25, 2014 Category: Gastroenterology Authors: Anchalee Avihingsanon, Salyavit Jitmitraparp, Pisit Tangkijvanich, Reshmie A. Ramautarsing, Tanakorn Apornpong, Supunee Jirajariyavej, Opass Putcharoen, Sombat Treeprasertsuk, Srunthron Akkarathamrongsin, Yong Poovorawan, Gail V Matthews, Joep MA Lange, K Tags: Hepatology Source Type: research

Positioning of 18F‐fluorodeoxyglucose‐positron emission tomography imaging in the management algorithm of hepatocellular carcinoma
ConclusionsPET allows detection of HCC spread in patients with elevated serum α‐fetoprotein levels or those beyond Milan criteria and detects EHMs in patients with PLs with high SUVmax values. Optimally timed PET scans can complement conventional imaging for accurate staging and treatment strategy determination. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 25, 2014 Category: Gastroenterology Authors: Etsushi Kawamura, Susumu Shiomi, Kohei Kotani, Joji Kawabe, Atsushi Hagihara, Hideki Fujii, Sawako Uchida‐Kobayashi, Shuji Iwai, Hiroyasu Morikawa, Masaru Enomoto, Yoshiki Murakami, Akihiro Tamori, Norifumi Kawada Tags: Hepatology Source Type: research

Neonatal monosodium glutamate treatment causes obesity, diabetes, and macrovesicular steatohepatitis with liver nodules in DIAR mice
ConclusionsDIAR‐MSG had NASH‐like liver pathology and liver nodules typically associated with MS symptoms. DIAR‐MSG provides a valuable animal model to analyze NASH pathogenesis and carcinogenesis. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - August 25, 2014 Category: Gastroenterology Authors: Koichi Tsuneyama, Takeshi Nishida, Hayato Baba, Shu Taira, Makoto Fujimoto, Kazuhiro Nomoto, Shinichi Hayashi, Shigeharu Miwa, Takahiko Nakajima, Mitsuko Sutoh, Emu Oda, Ryoji Hokao, Johji Imura Tags: Hepatology Source Type: research

Bacterial melanin crosses the blood-brain barrier in rat experimental model
Conclusions: These results show that bacterial melanin has saturable transport across the BBB and selectively targets some CNS regions. Such transport may contribute to the neuroprotective action of bacterial melanin. (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - August 25, 2014 Category: Neurology Authors: Tigran PetrosyanAnichka Hovsepyan Source Type: research

Noninvasive Assessment of Liver Fibrosis Using Ultrasound-Based Shear Wave Measurement and Comparison to Magnetic Resonance Elastography
Conclusions— Results indicate that the ultrasound-based shear wave measurement correlates with MRE and is a promising method for liver fibrosis staging. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - August 25, 2014 Category: Radiology Authors: Zhao, H., Chen, J., Meixner, D. D., Xie, H., Shamdasani, V., Zhou, S., Robert, J.-L., Urban, M. W., Sanchez, W., Callstrom, M. R., Ehman, R. L., Greenleaf, J. F., Chen, S. Tags: Original Research Source Type: research

Liver injury from herbals and dietary supplements in the U.S. Drug‐Induced Liver Injury Network
Conclusions: The proportion of liver injury cases attributed to HDS in DILIN has increased significantly. Liver injury from nonbodybuilding HDS is more severe than from bodybuilding HDS or medications, as evidenced by differences in unfavorable outcomes (death and transplantation). (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Victor J. Navarro, Huiman Barnhart, Herbert L. Bonkovsky, Timothy Davern, Robert J. Fontana, Lafaine Grant, K. Rajender Reddy, Leonard B. Seeff, Jose Serrano, Averell H. Sherker, Andrew Stolz, Jayant Talwalkar, Maricruz Vega, Raj Vuppalanchi Tags: Liver Injury and Regeneration Source Type: research

Historical, present, and future significance of corticosteroid in the treatment of acute liver failure
(Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Keiichi Fujiwara, Shin Yasui, Osamu Yokosuka Tags: Correspondence Source Type: research

Effects of purified eicosapentaenoic and docosahexaenoic acids in nonalcoholic fatty liver disease: Results from the WELCOME* study
Conclusion: Erythrocyte DHA enrichment with DHA+EPA treatment is linearly associated with decreased liver fat percentage. Substantial decreases in liver fat percentage can be achieved with high‐percentage erythrocyte DHA enrichment in NAFLD. (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Eleonora Scorletti, Lokpal Bhatia, Keith G. McCormick, Geraldine F. Clough, Kathryn Nash, Leanne Hodson, Helen E. Moyses, Philip C. Calder, Christopher D. Byrne, Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Relationship of hepatitis C virus infection with diabetes in the U.S. population
Conclusion: In the U.S. population, HCV was not associated with diabetes or with IR among persons with normal glucose. Previously reported relationships of HCV with diabetes were possibly attributable to the effect of elevated liver enzymes. (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Constance E. Ruhl, Andy Menke, Catherine C. Cowie, James E. Everhart Tags: Viral Hepatitis Source Type: research

Discovery and validation of urinary metabotypes for the diagnosis of hepatocellular carcinoma in West Africans
Conclusion: The urinary metabotyping of this West African cohort identified and validated a metabolite panel that diagnostically outperforms serum AFP. (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Nimzing G. Ladep, Anthony C. Dona, Matthew R. Lewis, Mary M.E. Crossey, Maud Lemoine, Edith Okeke, Yusuke Shimakawa, Mary Duguru, Harr F. Njai, Haddy K.S. Fye, Makie Taal, John Chetwood, Ben Kasstan, Shahid A. Khan, Deborah A. Garside, Anisha Wijeyesekera Tags: Hepatobiliary Malignancies Source Type: research

TIGIT safeguards liver regeneration through regulating natural killer cell‐hepatocyte crosstalk
Conclusion: TIGIT is a safeguard molecule to improve liver regeneration through negatively regulating NK‐hepatocyte crosstalk. This finding suggests a novel mechanism of NK cell self‐tolerance towards regenerative hyperplasia of the host. (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Jiacheng Bi, Xiaodong Zheng, Yongyan Chen, Haiming Wei, Rui Sun, Zhigang Tian Tags: Liver Injury and Regeneration Source Type: research

MicroRNAs play a role in spontaneous recovery from acute liver failure
Conclusion: Our data suggest that miR‐122, miR‐21, and miR‐221 are involved in liver regeneration and might contribute to spontaneous recovery from ALF. Prospective studies will show whether serological detection of those miRNAs might be of prognostic value to predict ALF outcome. (Hepatology 2014) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Katharina John, Johannes Hadem, Till Krech, Kristin Wahl, Michael P. Manns, Steven Dooley, Sandor Batkai, Thomas Thum, Klaus Schulze‐Osthoff, Heike Bantel Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research

Bile acids alter male fertility through G‐protein‐coupled bile acid receptor 1 signaling pathways in mice
Conclusions: These data identify the testis as a new target of BAs and emphasize TGR5 as a critical element in testicular pathophysiology. This work may open new perspectives on the potential effect of BAs on testis physiology during liver dysfunction. (Hepatology 2014;60:1054‐1065) (Source: Hepatology)
Source: Hepatology - August 25, 2014 Category: Internal Medicine Authors: Marine Baptissart, Aurélie Vega, Emmanuelle Martinot, Aurélien J. Pommier, Sander M. Houten, Geoffroy Marceau, Angélique de Haze, Silvère Baron, Kristina Schoonjans, Jean‐Marc A. Lobaccaro, David H. Volle Tags: Liver Biology/Pathobiology Source Type: research

Dissecting the complement pathway in hepatic injury and regeneration with a novel protective strategy
We describe a novel site-targeted murine complement inhibitor, CR2-CD59, which specifically inhibits the terminal membrane attack complex (MAC), and we use this protein to investigate the complement-dependent balance between liver injury and regeneration in a clinical setting of pharmacological inhibition. CR2-CD59 did not impact in vivo generation of C3 and C5 activation products but was as effective as the C3 activation inhibitor CR2-Crry at ameliorating hepatic IRI, indicating that the MAC is the principle mediator of hepatic IRI. Furthermore, unlike C3 or C5 inhibition, CR2-CD59 was not only protective but significantl...
Source: The Journal of Experimental Medicine - August 25, 2014 Category: Internal Medicine Authors: Marshall, K. M., He, S., Zhong, Z., Atkinson, C., Tomlinson, S. Tags: Articles Source Type: research

Low RNA translation activit limits the efficacy of hydrodynamic gene transfer to pig liver in vivo
ConclusionsThe results suggest that the low activity of mRNA translation limits the final efficacy of the gene transfer procedure. On the other hand, the gold nanoparticles study suggests that elongated DNA conformation could offer advantages in that the access of 15‐nm particles is very limited. Copyright © 2014 John Wiley & Sons, Ltd. (Source: The Journal of Gene Medicine)
Source: The Journal of Gene Medicine - August 25, 2014 Category: Genetics & Stem Cells Authors: Luis Sendra, Omar Carreño, Antonio Miguel, Eva Montalvá, María José Herrero, Francisco Orbis, Inmaculada Noguera, Domingo Barettino, Rafael López‐Andújar, Salvador F. Aliño Tags: Research Article Source Type: research

Geographic disparity: the dilemma of lower socioeconomic status, multiple listing, and death on the liver transplant waiting list
Abstract Due to the current regionally based allocation system, some patients list for and are transplanted away from home in regions with shorter waits and higher transplant rates. Of 147 included patients, 120 died waiting and 27 received transplants at outside centers during the study (32.5 months). Those transplanted elsewhere had higher median incomes than patients dying on the waitlist ($84 946 vs. $55 250, p = 0.0001). Those with median incomes <$60 244 were more likely to die than those with incomes >$60 244 (94% vs. 70%, RR: 1.35, 95% CI: 1.14–1.59). Patients with Medicaid were more likely to die wa...
Source: Clinical Transplantation - August 25, 2014 Category: Transplant Surgery Authors: Adam Schwartz, Thomas Schiano, Leona Kim‐Schluger, Sander Florman Tags: Original Article Source Type: research

Intravenous lipid microspheres loaded with alkylated norcantharidin derivative norcantharimide: Improved stability and prolonged half‐life
To facilitate the preparation of lipid microspheres, norcantharimide, a C14 alkyl chain derivative of norcantharidin, was synthesized and its physicochemical properties were investigated. The N‐14NCTDA loaded lipid microspheres (N‐14NCTDA LMs) were prepared by a high‐pressure homogenization method and characterized in terms of size, zeta‐potential, encapsulation efficiency and stability. The apparent oil–water partition coefficient of N‐14NCTDA (Log P > 2) was considerably enhanced in comparison to NCTD (Log P (−1.06), pH = 7.4). After optimization of the lipid microsphere formulation, the particle...
Source: European Journal of Lipid Science and Technology - August 25, 2014 Category: Lipidology Authors: Zhendong Pan, Yantao Niu, Yueqi Wang, Yilin Tang, Xing Tang, Cuifang Cai Tags: Research Article Source Type: research

Guideline of Guidelines
(Source: BJU International)
Source: BJU International - August 25, 2014 Category: Urology & Nephrology Authors: Prokar Dasgupta Tags: Editorial Source Type: research

Neutrophil‐to‐lymphocyte ratio as a prognostic factor in upper tract urothelial cancer
(Source: BJU International)
Source: BJU International - August 25, 2014 Category: Urology & Nephrology Authors: Moben Mirza Tags: Editor's Choice Source Type: research

Should centralized histopathological review in penile cancer be the global standard? A call for the international adoption of penile specialist networks
(Source: BJU International)
Source: BJU International - August 25, 2014 Category: Urology & Nephrology Authors: Catherine M. Corbishley Tags: Editor's Choice Source Type: research

Perioperative aspirin: To give or not to give?
(Source: BJU International)
Source: BJU International - August 25, 2014 Category: Urology & Nephrology Authors: Akshay Sood, Quoc‐Dien Trinh Tags: Editor's Choice Source Type: research