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Urology & Nephrology

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

USC Stem Cell scientists lay a TRAP for disease
(University of Southern California - Health Sciences) USC Stem Cell scientists have set a 'mouse TRAP' to capture the early signs of kidney failure, as described by a recent study published in the Journal of Clinical Investigations. Their new transgenic mouse line uses a technique called TRAP to extract cellular and genetic information from a variety of solid organs. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 11, 2014 Category: Biology Source Type: news

TPR Podcast Episode #5: Don’t Harsh Our Mellow, Dude!
This study looked at the rates of registered medical marijuana users pre- and post-legalization of marijuana in Colorado and compared it to rates of positive urine and serum marijuana tests of Colorado drivers involved in a fatal motor vehicle crash o   It found a positive correlation: as the rates of marijuana users went up, the rates of fatal motor vehicle crashes in which drivers tested positive for marijuana went up as well Critique of the article: o   Urine tests can be positive for days-months after the last use so drivers who tested positive for marijuana were not necessarily under the influen...
Source: The Poison Review - July 11, 2014 Category: Toxicology Authors: LeonThe Poison Review Tags: Podcast Source Type: news

Metastatic renal cell carcinoma to the jaws: report of cases
This report describes the diagnostic proceduresutilized and the therapeutic process in the two cases. The differential diagnosis and treatment methods are discussed. (Source: Epidemiologic Perspectives and Innovations)
Source: Epidemiologic Perspectives and Innovations - July 11, 2014 Category: Epidemiology Authors: Louqiang ZhangHongbin YangXuebin Zhang Source Type: research

Study Links Vasectomy to Aggressive Prostate Cancer
But the finding doesn't prove cause-and-effect; urologists call for more research (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - July 11, 2014 Category: Cancer & Oncology Source Type: news

Combined use of ursodeoxycholic acid and bosentan prevents liver toxicity caused by endothelin receptor antagonist bosentan monotherapy: two case reports
Conclusions: These reports suggest the usefulness of ursodeoxycholic acid for preventing liver toxicity caused by bosentan. Thus, the addition of ursodeoxycholic acid to the treatment protocol is expected to be useful when liver toxicity emerges as a side effect of bosentan. (Source: BioMed Central)
Source: BioMed Central - July 11, 2014 Category: Journals (General) Authors: Tomoki ItoYoshio OzakiYonsu SonTohru NishizawaHideki AmuroAkihiro TanakaTakeshi TamakiShosaku Nomura Source Type: research

An audit on the prescribing of intravenous fluids in paediatric patients
Conclusion Based on the objectives set, not all of the standards achieved 100% compliance. Prescribers need to be educated on paediatric IV fluid prescribing, and the importance of conducting daily U&E monitoring. The IV fluid section on paediatric drug charts also needs to be reviewed to enhance the ease of prescribing IV fluids correctly to prevent hospital induced hyponatraemia and enhance patient safety. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Howell, C., Patel, B. Tags: POSTERS Source Type: research

Paediatric discharge prescribing errors
Conclusion Though prescribing errors in paediatric hospital settings are prevalent, limited literature is available on the incidence of paediatric prescribing errors at the discharge stage. The incidence of prescribing errors identified on the paediatric and neonatal wards at discharge is relatively high. Recommendations to help reduce prescribing errors such as periodical assessment, regular audits and the use of a training program to highlight issues surrounding prescribing errors at discharge have been proposed. Other recommendations such as improving aspects of the electronic prescribing system have also been suggested...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Abiary, A. E., Al-Azeib, S. Tags: POSTERS Source Type: research

Post transplant medicine education--a collaborative approach
Conclusion The success of our kidney transplant programme is multi-factorial but we feel that empowering our young patients to be proactive in their long term care is a key to this success. This positively impacts on their individual quality of life as they have fewer co-morbidities and less inpatient episodes. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Thornhill, T., Hayes, P., Walsh, G., McCulloch, M., Taylor, J., Koffman, G. Tags: POSTERS Source Type: research

Mycophenolic acid (myfortic) is an alternative for paediatric renal transplant recipients with gastrointestinal symptoms on mycophenolate mofetil
Conclusion We have found that enteric-coated mycophenolic acid (Myfortic) was a well-tolerated alternative in paediatric renal allograft recipients who developed gastrointestinal symptoms whilst receiving mycophenolate mofetil. Its usage should be considered in such patients who are able to take tablet preparations. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Jones, H., Thornhill, W., Walsh, G., Taylor, J. Tags: POSTERS Source Type: research

Impact of short-term iv paracetamol in high risk neonates
Conclusion Short duration of IV paracetamol treatment in post-operative neonates on TPN, morphine and antibiotics has minimal impact on liver function in the absence of severe sepsis. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Windscheif, P., Mishra, G., Welsh, R., Lakhoo, K. Tags: POSTERS Source Type: research

The use of smof lipids in critically ill, and post surgical children on picu: a retrospective cohort study
Conclusions Patients who received SMOF had a similar mortality rate compared to those on other type of lipids despite their higher proportion with sepsis and their significantly prolonged time on PN. There was no relationship between the lipid dose and LFT's suggesting that adequate doses of lipids in the presence of sepsis and raised LFT's are not contraindicated. Although firm conclusions cannot be drawn, data from this study should prove useful in the assessment of SMOF use in septic and post surgical children and in the planning of a future large scale study. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Almossawi, O., Meadows, N., O'Brien, S., Brierley, N., Wong, I. Tags: POSTERS Source Type: research

Parents of paediatric liver transplant patients--opinions and experiences of medication issues
Conclusion This study provides an understanding of the issues encountered with post-transplant medication management, and describes the parents' perspectives in order to evolve our practice according to their real needs. Numerous medicines related problems were identified. However, the current multidisciplinary team (including doctors, specialist nurses and pharmacy staff) seem effective in preventing children from missing doses. Due to the problems reported concerning adverse drug effects the development of thorough information sessions for parents in this domain should be considered. Although parents seemed particularly ...
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Gutermann, L., Sharif, K., Rieutord, A., Terry, D. Tags: POSTERS Source Type: research

Propylene glycol intake from medications used on paediatric intensive care
Conclusions Certain formulations used on PICU can considerably increase PG exposure to patients. Due to a lack of awareness of PG content, these should be highlighted to the clinician to assist with making informed decisions regarding risks versus benefits in continuing that drug, route of administration or formulation. (Source: Archives of Disease in Childhood)
Source: Archives of Disease in Childhood - July 11, 2014 Category: Pediatrics Authors: Patel, C., Langley, C., Isaac, R. Tags: POSTERS Source Type: research

Determining the validity and reliability of the Chinese version of the Kidney Disease Quality of Life Questionnaire (KDQOL-36TM)
Conclusions: The Mandarin Chinese version of the KDQOL-36TM is a brief, valid, and reliable instrument used to examine the quality of life of chronic kidney disease patients in China. (Source: BMC Nephrology)
Source: BMC Nephrology - July 11, 2014 Category: Urology & Nephrology Authors: Xingjuan TaoSusan ChowFrances Wong Source Type: research

Is There an Ideal Cutoff for Alpha‐fetoprotein as an Exclusion Criterion for Liver Transplantation?
(Source: Liver Transplantation)
Source: Liver Transplantation - July 11, 2014 Category: Transplant Surgery Authors: Luciana dos Santos Schraiber, Angelo Mattos, Maria Zanotelli, Guido Cantisani Tags: Letters to the Editor Source Type: research

To Whom Goes the Kidney?
(Source: Liver Transplantation)
Source: Liver Transplantation - July 11, 2014 Category: Transplant Surgery Authors: Jayme E. Locke Tags: Editorial Source Type: research

Reply to the letter
(Source: Liver Transplantation)
Source: Liver Transplantation - July 11, 2014 Category: Transplant Surgery Authors: Kaoru Tsuchiya, Yasuhiro Asahina, Masayuki Kurosaki, Nobuyuki Enomoto, Namiki Izumi Tags: Letters to the Editor Source Type: research

Reframing the impact of combined heart‐liver allocation on liver transplant waitlist candidates
Abstract Simultaneous heart‐liver transplantation, although rare, has become more common in the U.S. When the primary organ is a heart or liver, patients receiving an offer for the primary organ automatically receive the second, non‐primary organ from that donor. This policy raises issues of equity—i.e. whether liver transplant‐alone candidates bypassed by heart‐liver recipients are disadvantaged. No prior published analyses have addressed this issue, and few methods have been developed as a means to measure the impact of such allocation policies. We analyzed OPTN match run data from 2007‐2013 to determine whet...
Source: Liver Transplantation - July 11, 2014 Category: Transplant Surgery Authors: David S. Goldberg, Peter P. Reese, Sandra Amaral, Peter L. Abt Tags: Original Article Source Type: research

The risk factors for tuberculosis in liver or kidney transplant recipients
Conclusions: The incidence density of TB among liver or kidney transplant recipients was much higher than in the general Chinese population. Recipients receiving a graft from a cadaveric donor and the preoperative evidence of latent TB were two major risk factors for developing TB in liver or kidney transplant recipients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - July 11, 2014 Category: Infectious Diseases Authors: Jia LiuJin YanQiquan WanQifa YeYisheng Huang Source Type: research

Optimization of intra‐voxel incoherent motion imaging at 3.0 Tesla for fast liver examination
ConclusionResults showed that IVIM could be performed in free breathing, with a weighted‐averaging procedure, a simultaneous diffusion gradient scheme and only four optimized b‐values (0, 10, 80, and 800) reducing scan duration by a factor of nine compared with a nonoptimized protocol. Preliminary results have shown that parameters such as DSlow and DFast based on optimized IVIM protocol can be relevant biomarkers to distinguish between nonadvanced and advanced fibrosis. J. Magn. Reson. Imaging 2014. © 2014 Wiley Periodicals, Inc. (Source: Journal of Magnetic Resonance Imaging)
Source: Journal of Magnetic Resonance Imaging - July 11, 2014 Category: Radiology Authors: Benjamin Leporq, Hervé Saint‐Jalmes, Cecile Rabrait, Frank Pilleul, Olivier Guillaud, Jérôme Dumortier, Jean‐Yves Scoazec, Olivier Beuf Tags: Original Research Source Type: research

Red blood cell (RBC) transfusion rates among US chronic dialysis patients during changes to medicare end-stage renal disease (ESRD) reimbursement systems and erythropoiesis stimulating agent (ESA) labels
Conclusions: The regulatory and reimbursement changes implemented in 2011 may have contributed to an increase in the use of RBC transfusions in chronic dialysis patients in the MarketScan dataset who were covered by Medicare plus Medicare supplemental insurance. (Source: BMC Nephrology)
Source: BMC Nephrology - July 11, 2014 Category: Urology & Nephrology Authors: Katherine CappellSanatan ShreayZhun CaoHelen VarkerCarly PaoliMatthew Gitlin Source Type: research

Prevalence of low testosterone and predisposing risk factors in men with type 1 diabetes mellitus: findings from the dcct/edic.
Conclusion: The men with T1DM in the EDIC cohort do not appear to have a high prevalence of androgen deficiency. Risk factors associated with low testosterone levels in this population are similar to the general population. PMID: 25013994 [PubMed - as supplied by publisher] (Source: Diabetes Metab)
Source: Diabetes Metab - July 11, 2014 Category: Endocrinology Authors: Holt SK, Lopushnyan N, Hotaling J, Sarma AV, Dunn RL, Cleary PA, Braffett BH, Gatcomb P, Martin C, Herman WH, Wessells H, the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications Research Group Tags: J Clin Endocrinol Metab Source Type: research

α-Tocopherol Supplementation of Allergic Female Mice Inhibits Development of CD11c+CD11b+ Dendritic Cells in Utero and Allergic Inflammation in Neonates.
In conclusion, maternal supplementation with α-tocopherol reduced fetal development of subsets of dendritic cells that are critical for allergic responses and reduced development of allergic responses in pups from allergic mothers. These results have implications for supplementation of allergic mothers with α-tocopherol. PMID: 25015974 [PubMed - as supplied by publisher] (Source: Am J Physiol Lung Ce...)
Source: Am J Physiol Lung Ce... - July 11, 2014 Category: Respiratory Medicine Authors: Abdala-Valencia H, Berdnikovs S, Soveg F, Cook-Mills JM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Effects of vitamin D on parathyroid hormone and clinical outcomes in peritoneal dialysis: a narrative review.
Abstract Vitamin D deficiency is very prevalent in dialysis and peritoneal dialysis (PD) patients show lower levels of cholecalciferol (25(OH)D3) than hemodialysis patients. We conducted a systematic narrative review to assess the effects of vitamin D therapy on control of secondary hyperparathyroidism and clinical outcomes induced by vitamin D pleiotropic effects. Medline database was searched for cohort and intervention studies reporting data on vitamin D (all sterols including synthetic analogs) and peritoneal dialysis without language restriction. Two authors independently extracted data. Twenty-nine observatio...
Source: Journal of Nephrology - July 11, 2014 Category: Urology & Nephrology Authors: Russo R, Ruospo M, Cozzolino M, De Nicola L, Icardi A, Paoletti E, Mazzaferro S Tags: J Nephrol Source Type: research

Interaction of diet and the masou salmon Δ5-desaturase transgene on Δ6-desaturase and stearoyl-CoA desaturase gene expression and N-3 fatty acid level in common carp (Cyprinus carpio).
Abstract The masou salmon Δ5-desaturase-like gene (D5D) driven by the common carp β-actin promoter was transferred into common carp (Cyprinus carpio) that were fed two diets. For P1 transgenic fish fed a commercial diet, Δ6-desaturase-like gene (D6D) and stearoyl-CoA desaturase (SCD) mRNA levels in muscle were up-regulated (P < 0.05) 12.7- and 17.9-fold, respectively, and the D6D mRNA level in the gonad of transgenic fish was up-regulated 6.9-fold (P < 0.05) compared to that of non-transgenic fish. In contrast, D6D and SCD mRNA levels in transgenic fish were dramatically down-regulated (P < 0.05),...
Source: Transgenic Research - July 11, 2014 Category: Genetics & Stem Cells Authors: Cheng Q, Su B, Qin Z, Weng CC, Yin F, Zhou Y, Fobes M, Perera DA, Shang M, Soller F, Shi Z, Davis A, Dunham RA Tags: Transgenic Res Source Type: research

Zinc and autophagy.
Abstract Autophagy is a highly conserved degradative process through which cells overcome stressful conditions. Inasmuch as faulty autophagy has been associated with aging, neuronal degeneration disorders, diabetes, and fatty liver, autophagy is regarded as a potential therapeutic target. This review summarizes the present state of knowledge concerning the role of zinc in the regulation of autophagy, the role of autophagy in zinc metabolism, and the potential role of autophagy as a mediator of the protective effects of zinc. Data from in vitro studies consistently support the notion that zinc is critical for early ...
Source: Biometals - July 11, 2014 Category: Biochemistry Authors: Liuzzi JP, Guo L, Yoo C, Stewart TS Tags: Biometals Source Type: research

Corrigendum to “Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men” [J Hepatol 2013;58:104–111]
(Source: Journal of Hepatology)
Source: Journal of Hepatology - July 11, 2014 Category: Gastroenterology Authors: Erawan Borkham-Kamphorst, Henning W. Zimmermann, Nikolaus Gassler, Ute Bissels, Andreas Bosio, Frank Tacke, Ralf Weiskirchen, Sandip M. Kanse Source Type: research

Experimental Infection of Mongolian Gerbils with Baylisascaris potosis.
Abstract Abstract The present study evaluated the pathogenicity of Baylisascaris potosis, a newly described ascarid nematode, in Mongolian gerbils. Gerbils were infected with varying doses of either B. potosis or Baylisascaris transfuga embryonated eggs (100, 1,000, and 4,000), for 30 days post infection (pi), and compared. B. potosis infected gerbils showed no clinical signs of disease, however, gerbils exposed to 1,000 and 4,000 B. transfuga eggs showed severe neurologic signs at 22-29 days and 14-15 days pi, respectively. Histopathologic examination revealed larvae and lesions in the intestine, lung, liver, and ...
Source: The Journal of Parasitology - July 11, 2014 Category: Parasitology Authors: Tokiwa T, Taira K, Une Y Tags: J Parasitol Source Type: research

In vivo antileishmanial efficacy of miltefosine against leishmania (leishmania) amazonensis.
IN VIVO ANTILEISHMANIAL EFFICACY OF MILTEFOSINE AGAINST LEISHMANIA (LEISHMANIA) AMAZONENSIS. J Parasitol. 2014 Jul 11; Authors: García Bustos MF, Barrio A, González Prieto G, Molina de Raspi E, Cimino R, Cardozo RM, Parada LA, Yeo M, Soto J, Uncos DA, Parodi C, Basombrío MA Abstract Abstract Leishmaniasis, a disease caused by parasites of the Leishmania genus, constitutes a significant health and social problem in many countries and is increasing worldwide. The conventional treatment, meglumine antimoniate (MA), presents numerous disadvantages, including invasiveness, toxicity and frequent therapeut...
Source: The Journal of Parasitology - July 11, 2014 Category: Parasitology Authors: García Bustos MF, Barrio A, González Prieto G, Molina de Raspi E, Cimino R, Cardozo RM, Parada LA, Yeo M, Soto J, Uncos DA, Parodi C, Basombrío MA Tags: J Parasitol Source Type: research

Molecular profile and functional characterization of the ferritin H subunit from rock bream (Oplegnathus fasciatus), revealing its putative role in host antioxidant and immune defense.
Abstract Ferritins are iron binding proteins made out of 24 subunits, involved in iron homeostasis and metabolism in cellular environments. Here, we sought to identify and functionally characterize a one type of subunits of ferritin (ferritin H-like subunit) from rock bream (Oplegnathus fasciatus; RbFerH). The complete coding sequence of RbFerH was 531 bp in length, encoding a 177-amino acid protein with a predicted molecular mass of 20.8 kDa. The deduced protein structure possessed the domain architecture characteristic of known ferritin H subunits, including metal ligands for iron binding, a ferroxidase center, a...
Source: Developmental and Comparative Immunology - July 11, 2014 Category: Allergy & Immunology Authors: Elvitigala DA, Priyathilaka TT, Lim BS, Whang I, Yeo SY, Choi CY, Lee J Tags: Dev Comp Immunol Source Type: research

Risk Factors and Outcomes of Acute Kidney Injury in Patients with Acute Liver Failure
(Source: Clinical Gastroenterology and Hepatology)
Source: Clinical Gastroenterology and Hepatology - July 11, 2014 Category: Gastroenterology Authors: Shannan R. Tujios, Linda S. Hynan, Miguel A. Vazquez, Anne M. Larson, Emmanuel Seremba, Corron M. Sanders, William M. Lee, Acute Liver Failure Study Group Source Type: research

Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering with GATA6 Signaling.
Conclusions: These results establish SHP as a novel anti-hypertrophic regulator that acts by interfering with GATA6 signaling. SHP may participate in the metformin-induced anti-hypertrophic response. PMID: 25015078 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - July 11, 2014 Category: Cardiology Authors: Nam YS, Kim Y, Joung H, Kwon DH, Choe N, Min HK, Kim Y, Kim HS, Kim DK, Cho YK, Kim YH, Nam KI, Choi HC, Park DH, Suk K, Lee IK, Ahn Y, Lee CH, Choi HS, Eom GH, Kook H Tags: Circ Res Source Type: research

Coronary CT Angiography and Incidental Pulmonary Nodules.
Abstract Incidental findings are an important topic in diagnostic imaging. Because of the comprehensive nature of computed tomography (CT) scanning, incidental findings are found seemingly on almost every CT scan performed for a wide variety of reasons in a radiology department. Many of these incidental findings are benign and immediately dismissed, such as a liver cyst. Other findings require more extensive interpretation and management. In regards to coronary CT angiography, a similar problem exists. Even though we have a primary interest in the heart, the CT scanner delivers radiation to all tissues of the chest...
Source: Circulation - July 11, 2014 Category: Cardiology Authors: Bluemke DA Tags: Circulation Source Type: research

Immune control and failure in HCV infection-tipping the balance.
Abstract Despite the development of potent antiviral drugs, HCV remains a global health problem; global eradication is a long way off. In this review, we discuss the immune response to HCV infection and particularly, the interplay between viral strategies that delay the onset of antiviral responses and host strategies that limit or even eradicate infected cells but also contribute to pathogenesis. Although HCV can disable some cellular virus-sensing machinery, IFN-stimulated antiviral genes are induced in the infected liver. Whereas epitope evolution contributes to escape from T cell-mediated immunity, chronic high...
Source: Journal of Leukocyte Biology - July 11, 2014 Category: Hematology Authors: Dustin LB, Cashman SB, Laidlaw SM Tags: J Leukoc Biol Source Type: research

The effect of recombinant adeno-associated virus-adiponectin (rAAV2/1-Acrp30) on glycolipid dysmetabolism and liver morphology in diabetic rats.
Abstract Adiponectin is an adipocytokine derived from adipocytes with insulin resistance-improving and anti-inflammatory activities. The level of Adiponectin is decreased in obesity, insulin resistance and Type 2 diabetes mellitus. The administration of recombinant adiponectin has been shown to improve hyperglycemia and insulin resistance in diabetic mice. Therefore, we investigated the effects of recombinant adeno-associated virus-adiponectin (rAAV2/1-Acrp30) on the glycolipid profile and liver morphology in streptozotocin-induced diabetic rats. Animals were fed a high-fat/high-glucose diet for 4 weeks and diabete...
Source: General and Comparative Endocrinology - July 11, 2014 Category: Endocrinology Authors: Long W, Ju ZH, Fan Z, Jing W, Qiong L Tags: Gen Comp Endocrinol Source Type: research

Glycogen storage disease type I: clinical and laboratory profile.
CONCLUSIONS: diagnosis of glycogen storage disease type I is delayed in Brazil. Most patients undergo liver biopsy for diagnostic confirmation, even though the combination of a characteristic clinical presentation and molecular methods can provide a definitive diagnosis in a less invasive manner. Obesity is a side effect of cornstarch therapy, and appears to be associated with growth in these patients. PMID: 25019649 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - July 11, 2014 Category: Pediatrics Authors: Santos BL, de Souza CF, Schuler-Faccini L, Refosco L, Epifanio M, Nalin T, Gonçalves SM, Schwartz IV Tags: J Pediatr (Rio J) Source Type: research

An alternative approach to account for patient organ doses from imaging guidance procedures.
CONCLUSIONS: It is adequate to estimate and account for organ dose by using tabulated values based on scan procedure and site because organ doses from imaging procedures are only modestly dependent upon scan location and body size. Considering the dose variation and magnitude of dose from each scan protocol in comparison to therapeutic doses, this approach provides a simple alternative to account for additional imaging guidance doses during patient treatment planning. Clinicians can use these tabulated values to make informed decisions in selecting the appropriate imaging procedures and imaging frequency during radiotherap...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - July 11, 2014 Category: Radiology Authors: Nelson AP, Ding GX Tags: Radiother Oncol Source Type: research

Febuxostat Ameliorates Diabetic Renal Injury in a Streptozotocin-Induced Diabetic Rat Model.
Conclusions: Febuxostat prevents diabetic renal injury such as albuminuria. This renoprotective effect appears to be due to attenuation of the inflammatory and oxidative effects of diabetes-induced renal damage through inhibition of XO and XDH activities. © 2014 S. Karger AG, Basel. PMID: 25034030 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - July 11, 2014 Category: Urology & Nephrology Authors: Lee HJ, Jeong KH, Kim YG, Moon JY, Lee SH, Ihm CG, Sung JY, Lee TW Tags: Am J Nephrol Source Type: research

Initial experience with electronic tracking of specific tumor sites in men undergoing active surveillance of prostate cancer.
CONCLUSIONS: Monitoring of specific prostate cancer-containing sites may be achieved in some men using an electronic tracking system. The chances of finding tumor on repeat specific-site sampling was directly related to the length of tumor in the initial biopsy core and presence of tumor within an MRI target; upgrading of Gleason score was uncommon. Further research is required to evaluate the potential utility of site-specific biopsy tracking for patients with prostate cancer on active surveillance. PMID: 25027689 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - July 11, 2014 Category: Urology & Nephrology Authors: Sonn GA, Filson CP, Chang E, Natarajan S, Margolis DJ, Macairan M, Lieu P, Huang J, Dorey FJ, Reiter RE, Marks LS Tags: Urol Oncol Source Type: research

Lymphopenia is an independent predictor of inferior outcome in papillary renal cell carcinoma.
CONCLUSIONS: In patients with PRCC, lymphopenia is associated with lower survival independent of TNM stage, age, and histology. ALC may provide an additional preoperative prognostic factor. PMID: 25027688 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - July 11, 2014 Category: Urology & Nephrology Authors: Mehrazin R, Uzzo RG, Kutikov A, Ruth K, Tomaszewski JJ, Dulaimi E, Ginzberg S, Abbosh PH, Ito T, Corcoran AT, Chen DY, Smaldone MC, Al-Saleem T Tags: Urol Oncol Source Type: research

Increased preoperative levels of plasma fibrinogen and d dimer in patients with renal cell carcinoma is associated with poor survival and adverse tumor characteristics.
CONCLUSIONS: Increased plasma fibrinogen levels accurately predict poor histopathologic and survival outcomes and may be an effective independent prognostic factor in patients with RCC. Moreover, d dimer may serve as a copredictive factor in conjunction with fibrinogen. PMID: 25027687 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - July 11, 2014 Category: Urology & Nephrology Authors: Erdem S, Amasyali AS, Aytac O, Onem K, Issever H, Sanli O Tags: Urol Oncol Source Type: research

Low preoperative lymphocyte-monocyte ratio (LMR) represents a potentially poor prognostic factor in nonmetastatic clear cell renal cell carcinoma.
CONCLUSIONS: Regarding CSS of patients with RCC, a decreased LMR represents an independent prognostic factor. Adding the LMR to well-established prognostic models, such as the Leibovich prognosis score, might improve their predictive ability. PMID: 25027686 [PubMed - as supplied by publisher] (Source: Urologic Oncology)
Source: Urologic Oncology - July 11, 2014 Category: Urology & Nephrology Authors: Hutterer GC, Stoeckigt C, Stojakovic T, Jesche J, Eberhard K, Pummer K, Zigeuner R, Pichler M Tags: Urol Oncol Source Type: research