Medicine RSS Search Engine

Urology & Nephrology Urology & Nephrology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Editorial Comment
The authors studied close to 2000 patients without known prostate cancer, each of whom had urine collected on first void after prostate biopsy. Their collection protocol differs from the more standard practice of collecting urine for PCA3 testing after an attentive digital rectal examination (DRE) or prostate massage. In theory, sampling urine after prostate manipulation—whether by DRE, attentive DRE, or transrectal ultrasonography and biopsy—allows for a comprehensive assessment of the prostate as such urine samples would be enriched in molecules derived from various parts of the prostate, even those not sampled by b...
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Christian Pavlovich Tags: Oncology Source Type: research

Editorial Comment
Molecular genetics used in the diagnosis and prognosis of prostate cancer is a hot topic! In addition to PCA3, there are now about a half-dozen novel molecular-based serum or tissue and urine-based markers at the clinician's disposal. Not only do urologists now have more choices, they have to learn the unique indications, tissue requirements and, perhaps most practical, the reimbursement status. Ironically, taking PCA3 as an example, as the efficacy data have gotten stronger, the US insurance reimbursement has become more problematic—more about that later. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Judd Moul Tags: Oncology Source Type: research

Reply
We currently do not know the precise source of cells for the overexpression of PCA3 messenger ribonucleic acid in urine, and studies originally showing a correlation between higher PCA3 scores and biopsy detection of prostate carcinoma (CaP) may have led to the likely oversimplified concept that foci of frankly invasive cancer within the stroma are the source of elevated urinary PCA3. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Jeffrey G. Brown, Scott B. Shappell Tags: Oncology Source Type: research

Reply
Yes, the molecular era for prostate is here! Nonetheless, patients and physicians still face many practical challenges, in particular, reimbursement from third-party payers, many of whom have not yet fully accepted the growing body of supportive data as well as the immense potential clinical benefit of molecular testing for prostate cancer. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Jeffrey G. Brown, Wayne Rigler, Scott B. Shappell Tags: Oncology Source Type: research

The Urinary Catheter and Its Significant Applications Described by Avicenna (980-1037 AD) in the Canon of Medicine
The designing and development of urinary catheter is indebted to the works and theories of scientists from various civilizations. The Persian physicians have been among the most influential scientists in the history of medicine and have described urinary catheter and its different usages in their manuscripts.1 Despite the destruction of much of the scientific documents including many precious writings in medical literature, there is valuable information about the miscellaneous methods of treatment in urologic diseases, especially catheter, in Persian medical textbooks of the Islamic Golden Age that have not been fully rese...
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Sina Kardeh, Rasool Choopani, Golnoush Sadat Mahmoudi Nezhad, Arman Zargaran Tags: History Source Type: research

The Role of Ultrasonography in Predicting Vesicoureteral Reflux
To evaluate the accuracy of renal and bladder ultrasonography (RBU) in predicting vesicoureteral reflux (VUR) in infants and children. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Arzu Kovanlikaya, Jacob Kazam, Allison Dunning, Dix Poppas, Valerie Johnson, Carlos Medina, Paula W. Brill Tags: Pediatric Urology Source Type: research

Transumbilical Single-incision Laparoscopic Versus Conventional Laparoscopic Upper Pole Heminephroureterectomy for Children With Duplex Kidney: A Retrospective Comparative Study
To present our experience regarding transumbilical single-incision laparoscopic heminephroureterectomy (SILH) in children with duplex kidney anomalies, and to investigate its feasibility and safety compared with those of conventional laparoscopic heminephroureterectomy (CLH). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Huixia Zhou, Shaoxiong Ming, Lifei Ma, Chao Wang, Xin Liu, Xiaoguang Zhou, Huawei Xie, Tian Tao, Sichao Ma, Wei Cheng Tags: Pediatric Urology Source Type: research

Is Extended Pharmacologic Venous Thromboembolism Prophylaxis Uniformly Safe After Radical Cystectomy?
To quantitate the risk of clinically significant renal function deterioration after radical cystectomy (RC), which could result in supratherapeutic levels of low-molecular-weight heparin (LMWH) and increased risk of bleeding events with the use of extended pharmacologic venous thromboembolism prophylaxis (EPVTEP) after hospital discharge. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Reza Mehrazin, Zachary Piotrowski, Brian Egleston, Daniel Parker, Jeffrey J. Tomaszweski, Marc C. Smaldone, Philip H. Abbosh, Timothy Ito, Paul Bloch, Kevan Iffrig, Marijo Bilusic, David Y.T. Chen, Rosalia Viterbo, Richard E. Greenberg, Robert G. Uzzo, Al Tags: Oncology Source Type: research

Reply
We appreciate the thoughtful comments on our study. The impetus for the study was the recommendation in the 2011 American Academy of Pediatrics guidelines that ultrasonography be used to select those patients who should undergo voiding cystourethrography (VCU) after a first urinary tract infection (UTI). We all had anecdotal experience with cases of grade IV and V reflux associated with normal sonograms, but this observation had not been studied systematically. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Paula W. Brill Tags: Pediatric Urology Source Type: research

Editorial Comment
Pediatric UrologyThe authors present a retrospective review of 134 patients with a history of vesicoureteral reflux to determine the utility of ultrasonography in detecting reflux based on voiding cystourethrography (VCU) findings. In the study period from 2005 to 2012, the authors categorize the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ultrasonography to detect vesicoureteral reflux with increasingly specific grades. A strong point in their study is the higher number of grade IV and V reflux present (27% of the cohort). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Jeffrey A. Stock, Gina Cambareri Tags: Pediatric Urology Source Type: research

Editorial Comment
One Size May Not Fit All (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Howard Brian Goldman Tags: Oncology Source Type: research

Reply
Deep-vein thrombosis and pulmonary thromboembolism are the major and potentially lethal complications of abdominal or pelvic cancer surgery. A noteworthy proportion of symptomatic venous thromboembolic events occur after hospital discharge. Appropriately, national guidelines recommend the use of extended pharmacologic venous thromboembolism prophylaxis (EPVTEP) for 4-week duration after pelvic surgery, including radical cystectomy. Nevertheless, such recommendations may not be appropriate for all patients. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Reza Mehrazin, Alexander Kutikov Tags: Oncology Source Type: research

Novel Cystine Ester Mimics for the Treatment of Cystinuria-induced Urolithiasis in a Knockout Mouse Model
To assess the effectiveness of l-cystine dimethyl ester (CDME), an inhibitor of cystine crystal growth, for the treatment of cystine urolithiasis in an Slc3a1 knockout mouse model of cystinuria. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Amrik Sahota, Jaspreet S. Parihar, Kathleen M. Capaccione, Min Yang, Kelsey Noll, Derek Gordon, David Reimer, Ill Yang, Brian T. Buckley, Marianne Polunas, Kenneth R. Reuhl, Matthew R. Lewis, Michael D. Ward, David S. Goldfarb, Jay A. Tischfield Tags: Basic and Translational Science Source Type: research

Incidence of Adverse Events After High Doses of OnabotulinumtoxinA for Multiple Indications
To determine the occurrence of all treatment-related adverse events (AEs), especially life-threatening AEs, after the injection of a cumulative dose of >360 units of onabotulinumtoxinA for multiple indications (neurogenic detrusor overactivity, lower limb spasticity, and so forth) within a 3-month interval. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Umaphorn Nuanthaisong, Nitya Abraham, Howard B. Goldman Tags: Female Urology Source Type: research

Exstrophy-epispadias Complex Presenting in Adulthood: A Single-center Review of Presentation, Management, and Outcomes
To study the presentation, management, and outcome of patients with exstrophy-epispadias complex, who present in adulthood (aged >18 years). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Vivek Venkatramani, J. Chandrasingh, Antony Devasia, Nitin S. Kekre Tags: Urologic Congenitalism Source Type: research

Renal Subcapsular Fluid Collection Caused by Penetration of a Pancreatic Pseudocyst
A 63-year-old man presented with left flank pain and spiked fever. Computed tomography revealed a pancreatic cyst and left renal subcapsular fluid collection that appeared to be connected to the cyst. High levels of amylase and lipase were observed in a test puncture of renal fluid collection. The cause of the fluid collection was diagnosed as penetration of the pancreatic pseudocyst. Endoscopic nasobiliary drainage was used to drain the pancreatic pseudocyst and renal subcapsular fluid collection. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Soki Kashima, Takamitsu Inoue, Mitsuru Chiba, Naoki Komine, Ryuichi Ito, Kazuyuki Numakura, Hiroshi Tsuruta, Mitsuru Saito, Susumu Akihama, Shintaro Narita, Norihiko Tsuchiya, Shigeru Satoh, Hirohide Onishi, Tomonori Habuchi Tags: Images in Clinical Urology Source Type: research

Technology Diffusion and Prostate Cancer Quality of Care
To evaluate the association of technological capacity with prostate cancer quality of care. Technological capacity was conceptualized as a market's ability to provide prostate cancer treatment with new technology, including robotic prostatectomy and intensity-modulated radiotherapy (IMRT). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Florian R. Schroeck, Samuel R. Kaufman, Bruce L. Jacobs, Ted A. Skolarus, Yun Zhang, Brent K. Hollenbeck Tags: Health Services Research Source Type: research

Evaluation of the Prognostic Significance of Altered Mammalian Target of Rapamycin Pathway Biomarkers in Upper Tract Urothelial Carcinoma
To evaluate the prognostic value of altered mammalian target of rapamycin (mTOR) pathway biomarkers in upper tract urothelial carcinoma (UTUC). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Aditya Bagrodia, Laura-Maria Krabbe, Bishoy A. Gayed, Payal Kapur, Ira Bernstein, Xian-Jin Xie, Christopher G. Wood, Jose A. Karam, Alon Z. Weizer, Jay D. Raman, Mesut Remzi, Nathalie Rioux-Leclerq, Andrea Haitel, Marco Roscigno, Christian Bolenz, Karim B Tags: Oncology Source Type: research

Editorial Comment
Health technology diffusion refers to the process whereby innovations are communicated through various channels and then picked up by physicians. A good example of this diffusion is the uptake of robots in urologic surgery suites and intensity-modulated radiotherapy in radiation clinics. The assumed causal relationship between adoption of these new technologies and improved quality of care has been upended by the results of the present study. Schroeck et al1 found no consistent relationship between technological capacity and adherence to nationally endorsed prostate cancer quality of care measures. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Terhi Hermanson, Oliver Sartor, Richard J. Ablin, Charles L. Bennett Tags: Health Services Research Source Type: research

Statin Medications Are Associated With a Lower Probability of Having an Abnormal Screening Prostate-specific Antigen Result
To investigate how statin use is associated with the probability of having an abnormal screening prostate-specific antigen (PSA) result according to common PSA thresholds for biopsy (>2.5, >4.0, and >6.5 ng/mL). (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Ying Shi, Kathy Z. Fung, Stephen J. Freedland, Richard M. Hoffman, Victoria L. Tang, Louise C. Walter Tags: Health Services Research Source Type: research

Processes of Care and the Impact of Surgical Volumes on Cancer-specific Survival: A Population-based Study in Bladder Cancer
To describe the relationships between procedure volume and late survival after cystectomy for muscle-invasive bladder cancer (MIBC) and explore variables explaining any effect. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: D. Robert Siemens, William J. Mackillop, Yingwei Peng, David Berman, Ahmed Elharram, Jonathan Rhee, Christopher M. Booth Tags: Health Services Research Source Type: research

Reply
We agree that the Veterans Affairs healthcare system has been a leader in developing national data systems that allow researchers to use “big data” to study real-world associations that impact clinical practice. There is great interest in the analysis of big data that integrates information from many thousands of people and/or various data sources to inform health care. For example, our study benefitted from having a sample size >300,000 men, which allowed us to identify large enough groups of men to study several measures of statin use and different prostate-specific antigen (PSA) thresholds and to perform adjusted an...
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Ying Shi, W. John Boscardin, Louise C. Walter Tags: Health Services Research Source Type: research

Editorial Comment
This study is a good example of how secondary data analysis of large data sets can assess causal relationships on a population level.1 The authors are congratulated for performing a rigorous analysis of >300,000 men undergoing prostate-specific antigen (PSA) testing in the Veterans Affairs (VA) healthcare system. Using extensive data cleaning across multiple VA data sets, they were able to link PSA results with statin prescriptions and demonstrate a significant dose-response relationship between increasing statin therapy and decreasing PSA levels. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Khurshid R. Ghani Tags: Health Services Research Source Type: research

Editorial Comment
Over the last decade, volume-outcome analysis has been a constant feature in the quality of care in surgery literature. It has been the platform on which we have continued the fundamental principles of Donabedian who perceived quality of care as the interaction of 3 key elements; structure, process, and outcome.1 (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Erik Mayer Tags: Health Services Research Source Type: research

Re: Crawford et al.: Long-term Tolerability and Efficacy of Degarelix: 5-Year Results From a Phase III Extension Trial With a 1-Arm Crossover From Leuprolide to Degarelix (Urology 2014;83:1122-1128)
I read with great interest this recent article by Crawford et al,1 which analyzed long-term tolerability and efficacy of degarelix on patients diagnosed with advanced prostate cancer and treated with degarelix and also on patients who had been previously treated with leuprolide and crossed over to degarelix. The authors stated that the prostate-specific antigen progression-free survival hazard rate for patients crossing over from leuprolide to degarelix significantly decreased from 0.20 during the first year to 0.09 during the extension phase. (Source: Urology)
Source: Urology - October 24, 2014 Category: Urology & Nephrology Authors: Mustafa Sofikerim Tags: Letter to the Editor Source Type: research