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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

The role of MRI in active surveillance for men with localized prostate cancer
Purpose of review: Active surveillance is the preferred management strategy for men with low-risk prostate cancer. Challenges in this field include improving patient selection, optimizing follow-up strategies, and identifying appropriate triggers for intervention. Advances in multiparametric MRI (mpMRI) have lead to improved detection of prostate tumors, and MRI has emerged as a tool to monitor men on active surveillance. We aim to review the latest developments in mpMRI to monitor active surveillance patients and describe areas of future research. Recent findings: mpMRI targeted prostate biopsy results in a higher detecti...
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: IMAGING IN PROSTATE CANCER - IMPLICATIONS FOR THE UROLOGIST: Edited by Mark Emberton Source Type: research

The role of multi-parametric MRI in loco-regional staging of men diagnosed with early prostate cancer
Purpose of review: To review the use of multi-parametric MRI (mpMRI) in loco-regional assessment of men with early prostate cancer. Recent findings: mpMRI comprises anatomic T2 and T1 sequences supplemented by functional imaging techniques such as diffusion-weighted and dynamic contrast enhanced (DCE) imaging. mpMRI is gaining increasing acceptance for prostate cancer detection and staging of early disease. It can facilitate targeted therapies, guide surgical options and enable active surveillance within suitable patients. The technique can be performed at 1.5 or 3 Tesla, but sequence optimization is critical to successful...
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: IMAGING IN PROSTATE CANCER - IMPLICATIONS FOR THE UROLOGIST: Edited by Mark Emberton Source Type: research

Using multiparametric MRI to ‘personalize’ biopsy for men
Purpose of review: In recent years, multiparametric magnetic resonance imaging (mpMRI) of the prostate has shown promise as a modality to identify areas of suspicion within the gland which correlate with cancer location and disease extent. However, optimal individualization of prostate biopsy using mpMRI relies on aligning the relative benefits of MRI-targeted approaches with the goals of biopsy. Recent findings: For men with prior negative biopsies, mpMRI allows improved detection of occult high-grade cancers missed by repeat systematic biopsy but also has the potential to identify men who will not benefit from repeat bio...
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: IMAGING IN PROSTATE CANCER - IMPLICATIONS FOR THE UROLOGIST: Edited by Mark Emberton Source Type: research

Can multiparametric MRI rule in or rule out significant prostate cancer?
Purpose of review: To show how multiparametric MRI can rule in the presence of significant prostate cancer (PCa), allowing for magnetic resonance-targeted biopsies to detect aggressive tumors eligible for immediate treatment and to evaluate if mp-MRI can rule out significant tumor foci to avoid overdiagnosis and overtreatment of PCa. Recent findings: Diffusion-weighted MRI plays a major role to detect tumor foci and to rule in significant PCa. A low apparent diffusion coefficient (ADC) value indicates that high Gleason grade tumors are present. Conversely, the absence of any suspicious focus or foci with a high apparent di...
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: IMAGING IN PROSTATE CANCER - IMPLICATIONS FOR THE UROLOGIST: Edited by Mark Emberton Source Type: research

A review of economic evaluations of diagnostic strategies using imaging in men at risk of prostate cancer
Purpose of review: The role of imaging, particularly MRI, in diagnosing clinically significant prostate cancer is the focus of a rapidly developing body of clinical research. We identified five economic evaluations of multiparametric magnetic resonance imaging (mpMRI) for diagnosing prostate cancer which report very different results. This review aims to explain why the reported cost-effectiveness of mpMRI varies so widely. Findings: The studies evaluate the cost-effectiveness of mpMRI within different clinical pathways; before biopsy and after a negative biopsy. Although there were important differences in the questions p...
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: IMAGING IN PROSTATE CANCER - IMPLICATIONS FOR THE UROLOGIST: Edited by Mark Emberton Source Type: research

Editorial introduction
No abstract available (Source: Current Opinion in Urology)
Source: Current Opinion in Urology - October 2, 2015 Category: Urology & Nephrology Tags: Editorial Introduction Source Type: research

Review of Bioptic Gleason Scores by Central Pathologist Modifies the Risk Classification in Prostate Cancer
Conclusion: Review of bioptic GSs by central pathologists affected discrepancies in risk classification in patients with PCa.Urol Int (Source: Urologia Internationalis)
Source: Urologia Internationalis - October 2, 2015 Category: Urology & Nephrology Source Type: research

The Effect of Preserved Residual Renal Function on Left Ventricular Structure in Non-Anuric Peritoneal Dialysis Patients
Conclusions: PD in non-anuric ESRD patients the first 18 months has a positive effect on the preservation of RRF and partial regression of left ventricular remodeling.Kidney Blood Press Res 2015;40:500-508 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - October 2, 2015 Category: Urology & Nephrology Source Type: research

Identification and Characterization of Liver MicroRNAs of the Chinese Tree Shrew via Deep Sequencing
Conclusions: According to the liver microRNA data of Chinese tree shrew, characteristics of the miR-122 and Let-7 families further highlight the suitability of tree shrew as the animal model in HCV research.,Objectives: This study aimed to construct a liver microRNA (miRNA) data of the tree shrew.,Materials and Methods: Three second filial generation tree shrews were used in this study. Total RNA was extracted from each liver of the tree shrew and equal quality mixed, then reverse-transcribed to complementary DNA (cDNA). The cDNAs were amplified by polymerase chain reaction and subjected to high-throughput sequencing.,Resu...
Source: Hepatitis Monthly - October 2, 2015 Category: Infectious Diseases Source Type: research

Summary of the Sixth BHD and First International Upstate Kidney Cancer Symposium
Ongoing clinical trials were discussed by Dr Jason Muhitch, who spoke about the AGS-003 immunotherapy trial (discussed in this blog post) and the potential of high-dose radiation to bolster anti-tumour immune responses, and Dr Namita Chittoria who discussed trials for papillary RCC caused by MET mutations.10/02/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - October 2, 2015 Category: Cancer & Oncology Source Type: news

Here's where to find a clinical trial for #kidneycancer #immunooncology
A fast, free, service from the Kidney Cancer Association and EmergingMed10/02/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - October 2, 2015 Category: Cancer & Oncology Source Type: news

After UCLA-led tests, immunotherapy drug approved by FDA to treat lung cancer
Pembrolizumab, a drug that has already been proven to extend the lives of people with advanced melanoma, has now been approved by the U.S. Food and Drug Administration to treat advanced non-small cell lung cancer. The study, the largest published research to date using immunotherapy to treat lung cancer, was conducted at UCLA and 29 other sites in the U.S., Europe and Australia. “The approval of this drug and a test to identify patients most likely to benefit has the potential to transform the way that lung cancer is treated,” said Dr. Edward Garon, the study’s principal investigator and a researcher at UCLA’s Jons...
Source: UCLA Newsroom: Health Sciences - October 2, 2015 Category: Universities & Medical Training Source Type: news

Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to
Abstract: The threat of radiation exposure from warfare or radiation accidents raises the need for appropriate animal models to study the acute and chronic effects of high dose rate radiation exposure. The goal of this study was to assess the late development of fibrosis in multiple organs (kidney, heart, and lung) in survivors of the C57BL/6 mouse model of the hematopoietic-acute radiation syndrome (H-ARS). Separate groups of mice for histological and functional studies were exposed to a single uniform total body dose between 8.53 and 8.72 Gy of gamma radiation from a 137Cs radiation source and studied 1–21 mo later. Bl...
Source: Health Physics - October 2, 2015 Category: Radiology Tags: Papers Source Type: research

Increased Expression of Connective Tissue Growth Factor (CTGF) in Multiple Organs After Exposure of Non-Human Primates (NHP) to Lethal Doses of Radiation
Abstract: Exposure to sufficiently high doses of ionizing radiation is known to cause fibrosis in many different organs and tissues. Connective tissue growth factor (CTGF/CCN2), a member of the CCN family of matricellular proteins, plays an important role in the development of fibrosis in multiple organs. The aim of the present study was to quantify the gene and protein expression of CTGF in a variety of organs from non-human primates (NHP) that were previously exposed to potentially lethal doses of radiation. Tissues from non-irradiated NHP and NHP exposed to whole thoracic lung irradiation (WTLI) or partial-body irradiat...
Source: Health Physics - October 2, 2015 Category: Radiology Tags: Papers Source Type: research

Why partnerships are key to the science of patient input
By: Nina L. Hunter and Robert M. Califf, M.D. We recently announced the first FDA Patient Engagement Advisory Committee (PEAC), supported by the Center of Devices and Radiological Health (CDRH). The Committee will provide advice to the FDA Commissioner on complex issues relating to medical devices, the regulation of devices, and their use by patients. The PEAC will bring patients, patient advocacy groups, and experts together for a broader discussion of important patient-related issues, to increase integration of patient perspectives into the regulatory process, and to help drive more patient-centric medical device innovat...
Source: Mass Device - October 2, 2015 Category: Medical Equipment Authors: MassDevice Tags: Blog FDA Source Type: news

Baroreflex activation therapy in patients with end-stage renal failure: proof of concept
Background: Resistant arterial hypertension and chronic kidney disease (CKD) are interlinked via sympathetic overactivity. Baroreflex activation therapy (BAT) is a well tolerated therapy, which has been shown to reduce BP in patients with resistant hypertension. The effects of BAT in patients with resistant hypertension and end stage renal disease have not been reported. Method and results: We retrospectively analyzed procedural effectiveness and safety in seven CKD stage 5D patients with resistant hypertension who underwent BAT. One year after activation, office SBP decreased significantly from 194 ± 28 to 137 ±...
Source: Journal of Hypertension - October 2, 2015 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research

Kidney Stones: Very Scary True Stories. And Entombed Mysteries.
(Source: Medical News (via PRIMEZONE))
Source: Medical News (via PRIMEZONE) - October 2, 2015 Category: Pharmaceuticals Source Type: news

Kidney Cancer Association Launches Video Blog and New Website
Dedicated to helping patients better understand the role of immuno-oncology in treating renal cancers(PRWeb September 30, 2015)Read the full story at http://www.prweb.com/releases/kidney-cancer/ecco2015/prweb12992314.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - October 2, 2015 Category: Pharmaceuticals Source Type: news

The DreamRCT Collaboration: Why It's Essential
(MedPage Today) -- An introduction to DreamRCT 2015 (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - October 2, 2015 Category: Urology & Nephrology Source Type: news

High-fructose diet hampers recovery from traumatic brain injury
A diet high in processed fructose sabotages rats’ brains’ ability to heal after head trauma, UCLA neuroscientists report. Revealing a link between nutrition and brain health, the finding offers implications for the 5.3 million Americans living with a traumatic brain injury, or TBI. According to the Centers for Disease Control and Prevention, an estimated 1.7 million people suffer a TBI each year, resulting in 52,000 annual deaths “Americans consume most of their fructose from processed foods sweetened with high-fructose corn syrup,” said Fernando Gomez-Pinilla, a professor of neurosurgery and integrative biology an...
Source: UCLA Newsroom: Health Sciences - October 2, 2015 Category: Universities & Medical Training Source Type: news

Global Patterns of Hepatocellular Carcinoma ManagementGlobal Patterns of Hepatocellular Carcinoma Management
How is hepatocellular cancer treated around the world, and how do treatment patterns affect outcomes? Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 2, 2015 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Association of P-Wave Dispersion with Overall and Cardiovascular Mortality in Hemodialysis Patients
Conclusions: We concluded that PWdisperC was positively associated with overall and cardiovascular mortalities in hemodialysis patients and could provide additional prognostic values. Screening hemodialysis patients by using PWdisperC may facilitate identifying a group of patients with poor prognosis.Am J Nephrol 2015;42:198-205 (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - October 2, 2015 Category: Neurology Source Type: research

Health-related quality of life measurement in chronic liver disease patients.
CONCLUSIONS: Quality of life instruments are potentially powerful tools for evaluating the functional status, presenting gains of treatment and reflecting patients' ability to return to a normal lifestyle in CLD patients. More attention should be paid by clinicians for integrated use of clinical tests together with HRQOL instruments in liver transplantation for establishing the reference levels of mental, physical, and role-social functioning. PMID: 26424183 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - October 2, 2015 Category: Universities & Medical Training Authors: Šumskienė J, Kupčinskas L, Šumskas L Tags: Medicina (Kaunas) Source Type: research

Transient Elastography in End-Stage Renal Disease Patients on Hemodialysis: The Effect of Net Fluid Withdrawal
Conclusion: In ESRD on regular HD, LSM is not affected by HD. TE can be done before or after HD with similar results. However, fluid excess at pre-HD can cause inaccurately high LSM.Blood Purif 2015;40:256-259 (Source: Blood Purification)
Source: Blood Purification - October 2, 2015 Category: Hematology Source Type: research

PNPLA3 rs738409 Polymorphism Associated with Hepatic Steatosis and Advanced Fibrosis in Patients with Chronic Hepatitis C Virus: A Meta-Analysis.
Conclusions: PNPLA3 rs738409 (C>G) was associated with the risk of both advanced liver fibrosis and steatosis in patients with CHC, especially among Caucasian populations. PMID: 26419236 [PubMed - as supplied by publisher] (Source: Gut and Liver)
Source: Gut and Liver - October 2, 2015 Category: Gastroenterology Tags: Gut Liver Source Type: research

International agreement on MRI-scans 'likely to change how we detect prostate cancer'
(European Association of Urology) International radiological bodies have agreed on a standard for how doctors evaluate MRI to confirm a diagnosis of prostate cancer. This promises to reduce the number of over diagnosis of insignificant cancers by to up to 89 percent. The new procedure also allows radiologists to identify up to 13 percent more life-threatening tumors than current procedures. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 2, 2015 Category: Global & Universal Source Type: news

Abnormal Expression of Urea Transporter Protein in a Rat Model of Hepatorenal Syndrome Induced by Succinylated Gelatin.
CONCLUSIONS It is feasible to model ACS in rats by injecting succinylated gelatin into the abdominal cavity. Increasing the intra-abdominal pressure by succinylated gelatin is also a novel approach for modeling HRS in cirrhotic rats. Compared with control rats, there is an abnormal mRNA expression of UT in ACS rats and HRS rats. PMID: 26414230 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 2, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice.
Authors: Wright TT, Jimenez RV, Morgan TE, Bali N, Hou X, McCrory MA, Finch CE, Szalai AJ Abstract We recently demonstrated that human C-reactive protein (CRP), expressed hepatically in transgenic mice (CRPtg), improved the outcome of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The liver is the primary site of CRP synthesis in humans and in CRPtg mice but is also expressed by both at low levels in the CNS. To determine if CNS expression of human CRP is sufficient to impact EAE, we generated neuronal CRP transgenic mice (nCRPtg) wherein human CRP expression is driven b...
Source: Autoimmune Diseases - October 2, 2015 Category: Allergy & Immunology Tags: Autoimmune Dis Source Type: research

Lxr regulates lipid metabolic and visual perception pathways during zebrafish development
Publication date: Available online 30 September 2015 Source:Molecular and Cellular Endocrinology Author(s): Caroline Lucia Pinto, Sharanya Maanasi Kalasekar, Catherine W. McCollum, Anne Riu, Philip Jonsson, Justin Lopez, Eric Swindell, Abdel Bouhlatouf, Patrick Balaguer, Maria Bondesson, Jan-Åke Gustafsson The Liver X Receptors (LXRs) play important roles in multiple metabolic pathways, including fatty acid, cholesterol, carbohydrate and energy metabolism. To expand the knowledge of the functions of LXR signaling during embryonic development, we performed a whole-genome microarray analysis of Lxr target genes...
Source: Molecular and Cellular Endocrinology - October 2, 2015 Category: Endocrinology Source Type: research

Role of transient elastography (Fibroscan) in differentiating severe acute hepatitis and acute on chronic liver failure
Conclusion LSM could differentiate patients with severe AH and ACLF at admission. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 2, 2015 Category: Gastroenterology Source Type: research

Risk Factors Associated With Non-Alcoholic Fatty Liver Disease in Indians: A Case–Control Study
Conclusion The risk factors associated with NAFLD are sedentary lifestyle, obesity family history of MS, consumption of meat/fish, spicy foods, fried foods and tea. Other risk factors associated with NAFLD included snoring and MS. (Source: Journal of Clinical and Experimental Hepatology)
Source: Journal of Clinical and Experimental Hepatology - October 2, 2015 Category: Gastroenterology Source Type: research

Serum levels of endothelin‐1 after liver resection as an early predictor of postoperative liver failure. A prospective study
ConclusionET‐1 is as an early index of PLF and provides a rationale for therapeutic manipulation, with many potential clinical implications to prevent PLF onset and reduce its severity. (Source: Hepatology Research)
Source: Hepatology Research - October 2, 2015 Category: Internal Medicine Authors: Francesca Ratti, Carlo Pulitanò, Marco Catena, Michele Paganelli, Luca Aldrighetti Tags: Original Article Source Type: research

Comparative Analysis of Prostate Volume as a Predictor of Outcome in Prostate Artery Embolization
Conclusions PAE offers similar clinical benefits to patients with differing gland sizes and may offer a reasonable alternative for poor candidates for urologic surgery. (Source: Journal of Vascular and Interventional Radiology)
Source: Journal of Vascular and Interventional Radiology - October 2, 2015 Category: Radiology Source Type: research

First and repeat liver resection for primary and recurrent intrahepatic cholangiocarcinoma
Recurrence after resection of intrahepatic cholangiocarcinoma (ICC) remains common. The current study sought to evaluate risk factors for recurrence and the results of repeat liver resection (RLR) for recurrent ICC. (Source: American Journal of Surgery)
Source: American Journal of Surgery - October 2, 2015 Category: Surgery Authors: Regis Souche, Pietro Addeo, Elie Oussoultzoglou, Astrid Herrero, Edoardo Rosso, Francis Navarro, Jean Michel Fabre, Philippe Bachellier Source Type: research

Routine Liver Biopsy During Bariatric Surgery: an Analysis of Evidence Base
Abstract Non-alcoholic fatty liver disease and non-alcoholic steato-hepatitis are common in patients undergoing bariatric surgery. Non-alcoholic steato-hepatitis can progress to cirrhosis of the liver and hepatocellular carcinoma. Non-invasive methods of diagnosing non-alcoholic steato-hepatitis are not as accurate as liver biopsy, and bariatric surgery presents a unique opportunity to carry out a simultaneous liver biopsy. Routine liver biopsy can help early and accurate diagnosis of obesity-associated liver conditions. This has led some surgeons to argue for routine liver biopsy at the time of bariatric surgery....
Source: Obesity Surgery - October 2, 2015 Category: Surgery Source Type: research

Impact of Nonalcoholic Fatty Liver Disease on Myocardial Perfusion in Nondiabetic Patients Undergoing Primary Percutaneous Coronary Intervention for ST-segment Elevation Myocardial Infarction
We examined 186 consequtive nondiabetic patients (mean age 58±11 years and 76% male) who underwent primary PCI for STEMI by ultrasound within 72 hours of admission. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - October 2, 2015 Category: Cardiology Authors: Ayse Emre, Sait Terzi, Emel Celiker, Sinan Sahin, Selcuk Yazıcı, Aysun Erdem, Ufuk Sadik Ceylan, Murat Asik, Kemal Yesilcimen Source Type: research

Opioid Use in Hemodialysis Patients
Publication date: Available online 1 October 2015 Source:American Journal of Kidney Diseases Author(s): Robert E. Olivo, Robin L. Hensley, Julia B. Lewis, Sharmeela Saha (Source: American Journal of Kidney Diseases)
Source: American Journal of Kidney Diseases - October 2, 2015 Category: Urology & Nephrology Source Type: research

Reply by Elshal et al
We strongly agree with the comments regarding the benefit of complete enucleation of the adenoma, which can be achieved in even the largest glands. Good quality data support the use of enucleation techniques in larger glands to minimize reoperation rates. We recently reported low long-term complication and reoperation rates after HoLEP with better outcomes than the GreenLight XPS laser therapy system in improving patient quality of life.1,2 In the last few years we have witnessed a significant shift to using enucleation principles when tackling large glands with whatever energy source, from laser to bipolar technology. (So...
Source: The Journal of Urology - October 2, 2015 Category: Urology & Nephrology Source Type: research

Reply by Hueber et al
We agree that enucleation or creation of an enucleation-like defect is the key to achieving complete adenoma removal and affords long-term durable outcomes for treating large prostates. Although the trial by Elshal et al compared HoLEP to GreenLight vaporesection (as opposed to true GreenLight enucleation as described by Gomez Sancha1 and Brunken2 et al), their study shows a greater PSA reduction and better postoperative maximum urine flow rate after HoLEP, suggesting the latter as a likely more durable treatment option. (Source: The Journal of Urology)
Source: The Journal of Urology - October 2, 2015 Category: Urology & Nephrology Tags: Letter to the Editor/Errata Source Type: research