Medicine RSS Search Engine

Urology & Nephrology Urology & Nephrology RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Four Plus Forty-Four: Hours to Modify, Theirs to Enjoy.
PMID: 25614491 [PubMed - as supplied by publisher] (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - January 22, 2015 Category: Urology & Nephrology Authors: Jassal SV Tags: Clin J Am Soc Nephrol Source Type: research

Treatment of hepatic amyloid light‐chain amyloidosis with bortezomib and dexamethasone in a liver transplant patient
Hepatic amyloid light‐chain (AL) amyloidosis is characterized by abnormal deposition of amyloid fibrils in the liver. As this precursor protein is produced by a proliferative plasma cell clone in the bone marrow, liver transplantation (LT) does not affect the disease's progression. Here, we describe the successful treatment using bortezomib‐ and dexamethasone‐based chemotherapy, following LT, of hepatic AL amyloidosis in a 65‐year‐old woman with progressive liver failure. The patient presented with progressive hepatic dysfunction accompanied by hepatorenal syndrome requiring hemodialysis, and living donor LT was ...
Source: Hepatology Research - January 22, 2015 Category: Internal Medicine Authors: Ryosuke Nakano, Masahiro Ohira, Kentaro Ide, Kohei Ishiyama, Tsuyoshi Kobayashi, Hiroyuki Tahara, Hirotaka Tashiro, Yoshiaki Kuroda, Tatsuo Ichinohe, Koji Arihiro, Kazuaki Chayama, Hideki Ohdan Tags: Case Report Source Type: research

Synthesis, characterization and urease inhibition, in vitro anticancer and antileishmanial studies of Ni(II) complexes with N,N,N'-trisubstituted thioureas.
Abstract A series of N,N,N'-trisubstituted thioureas (1-12) and their Ni(II) complexes (1a-12a) were synthesized and characterized by multinuclear ((1)H and (13)C) NMR, FT-IR spectroscopy and LC-MS techniques in combination with elemental analysis. The crystal structures of both ligands and Ni(II) chelates of type Ni(L-O, S)2 were determined by single crystal X-ray diffraction analysis. All the complexes were adopted to have square planar geometry, where the N,N,N'-trisubstituted thioureas showed bidentate mode of coordination at nickel centre through oxygen and sulfur atoms. The synthesized complexes were screened...
Source: Journal of Biological Inorganic Chemistry : JBIC - January 22, 2015 Category: Chemistry Authors: Rauf MK, Yaseen S, Badshah A, Zaib S, Arshad R, Imtiaz-Ud-Din, Tahir MN, Iqbal J Tags: J Biol Inorg Chem Source Type: research

Nitrosative stress and apoptosis in non-anemic healthy rats induced by intravenous iron sucrose similars versus iron sucrose originator.
In this study, the potential of several marketed iron sucrose similars (ISSs) to induce tyrosine nitration and caspase 3 expression in non-anemic rats was assessed. Although the physico-chemical properties of most of the analyzed ISSs complied with the United States Pharmacopeia for iron sucrose injection, all ISSs resulted in higher levels of tyrosine nitration and increased the expression of caspase 3 versus ISORIG. Moreover, significant differences were detected in tissue iron distribution between ISORIG- and ISS-treated animals. In general, ISORIG resulted in higher levels of ferritin deposits versus ISSs whereas ISSs ...
Source: Biometals - January 22, 2015 Category: Biochemistry Authors: Toblli JE, Cao G, Angerosa M Tags: Biometals Source Type: research

Woman Donates Kidney to Adoptive Father
Brandi Hicks learned selflessness from her adoptive parents starting from when she was 6 months old and they took her in. (Source: ABC News: Health)
Source: ABC News: Health - January 21, 2015 Category: Consumer Health News Tags: Health Source Type: news

Tumor deposit in synchronous colorectal liver metastases
Lin Q, Wei Y, Ren L, Zhong Y, Qin C, Zheng P, Xu P, Zhu D, Ji M, Xu J (Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - January 21, 2015 Category: Cancer & Oncology Source Type: research

Music During Surgery
In this study, the difference between surgical procedures (surgical, urological, and orthopedic operations) might affect the perceived anxiety of the patients. (Source: Journal of PeriAnesthesia Nursing)
Source: Journal of PeriAnesthesia Nursing - January 21, 2015 Category: Nursing Authors: Sim Sai Tin, Viroj Wiwanitkit Tags: Letter to the Editor Source Type: research

Overview of hospitalizations by ambulatory care sensitive conditions in the municipality of Cotia, Brazil
Conclusion Chronic diseases predominate among the leading causes of HACSC and there was no significant difference between sex.

 Objetivo Describir el perfil de las Hospitalizaciones por Condiciones Sensibles de la Atención Primaria (HCSAP), en el municipio de Cotia, entre 2008 y 2012. Método Estudio ecológico, exploratorio, longitudinal con un enfoque cuantitativo. Los datos sobre HCSAP, por grupo de edad y sexo, se obtuvieron del Departamento del Sistema Único de Salud. Para el análisis de los datos se utilizaron estadísticas descriptiv...
Source: Revista da Escola de Enfermagem da USP - January 21, 2015 Category: Nursing Source Type: research

Rosetta Kidney Cancer Test™
Clinician Survey Supporting Value Proposition of the Rosetta Kidney Cancer Test™ Published in the Journal of Kidney Cancer.01/21/2015 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - January 21, 2015 Category: Cancer & Oncology Source Type: news

Dynamic changes of global DNA methylation and hypermethylation of cell adhesion-related genes in rat kidneys in response to ochratoxin A
Ochratoxin A (OTA), which is found in a variety of food products, is associated with the development of nephrotoxicity and carcinogenicity in rats and has raised public health concerns. A previous study in our laboratory indicated that OTA exposure induced cytotoxicity by decreasing global DNA methylation in vitro. However, the relationship between OTA-induced nephrotoxicity and DNA methylation changes in vivo remains unclear. The object of this study was to investigate whether OTA can change global DNA methylation or alter the expression of several critical tumour-related genes by inducing methylation modifications before...
Source: World Mycotoxin Journal - January 21, 2015 Category: Toxicology Tags: World Mycotoxin Journal Source Type: research

Bovine hepatic differential gene expression in response to perennial ryegrass staggers
The objective of this study was to characterise differential gene expression in the liver of animals fed lolitrem B-containing feed over an extended period of time. Eighteen steers were fed one of three rations (n=6/group) containing lolitrem B (247, 1,554 or 2,256 μg/kg (dry matter basis)) over 64 days in a double-blind study. Microarray and confirmatory qPCR were performed to evaluate the hepatic gene expression profile from biopsies taken on days 0 and 64. Widespread perturbation of gene expression was observed in all groups receiving lolitrem B, with a total of 152 differential genes identified (false discovery rate ...
Source: World Mycotoxin Journal - January 21, 2015 Category: Toxicology Tags: World Mycotoxin Journal Source Type: research

The effect of probiotics on serum levels of cytokine and endotoxin in peritoneal dialysis patients: a randomised, double-blind, placebo-controlled trial
In conclusion, probiotics could significantly reduce the serum levels of endotoxin, pro-inflammatory cytokines (TNF-α and IL-6), IL-5, increase the serum levels of anti-inflammatory cytokine (IL-10), and preserve residual renal function in PD patients. Content Type Journal ArticleCategory Research-ArticlePages 1-8DOI 10.3920/BM2014.0088Authors I.-K. Wang, Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, 2 Yue-Der Road, Taichung 404, TaiwanY.-Y. Wu, Department of Medical Laboratory Science and Biotechnology, China Medical University, 2 Yue-Der Road, Taichung 404, TaiwanY.-F....
Source: Beneficial Microbes - January 21, 2015 Category: Gastroenterology Tags: Beneficial Microbes Source Type: research

Is Cinacalcet Useful in Dialysis Patients?Is Cinacalcet Useful in Dialysis Patients?
Dr Jeffrey Berns reviews the latest research on cinacalcet's role in managing hemodialysis patients. Medscape Nephrology (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - January 21, 2015 Category: Urology & Nephrology Tags: Nephrology Commentary Source Type: news

Attenuation-Based Automatic Kilovoltage Selection and Sinogram-Affirmed Iterative Reconstruction: Effects on Radiation Exposure and Image Quality of Portal-Phase Liver CT.
CONCLUSION: Combined use of CARE kV and SAFIRE allowed significant reduction in radiation exposure while maintaining image quality in contrast-enhanced liver CT. PMID: 25598675 [PubMed - in process] (Source: Korean Journal of Radiology)
Source: Korean Journal of Radiology - January 21, 2015 Category: Radiology Tags: Korean J Radiol Source Type: research

Cancer Stem Cells in Primary Liver Cancers: Pathological Concepts and Imaging Findings.
Authors: Joo I, Kim H, Lee JM Abstract There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the re...
Source: Korean Journal of Radiology - January 21, 2015 Category: Radiology Tags: Korean J Radiol Source Type: research

Cystic Renal Cell CarcinomaCystic Renal Cell Carcinoma
Gain a better understanding of cystic renal cell carcinoma and the best approaches to diagnosing and managing this uncommon disease. BMC Urology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 21, 2015 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Does moderate boozing reduce heart failure risk?
Conclusion This study suggests drinking up to about 12 UK units a week is associated with a lower risk of heart failure in men compared with never drinking alcohol. There was a similar result for women, but the results were not as robust and did not rule out the possibility of there being no difference. The study benefits from its large size (more than 14,000 people) and the fact it collected its data prospectively over a long period of time. However, studying the impact of alcohol on outcomes is fraught with difficulty. These difficulties include people not being entirely sure what a "drink" or a "unit&q...
Source: NHS News Feed - January 21, 2015 Category: Consumer Health News Tags: Heart/lungs Food/diet Source Type: news

Efficacy and safety of a novel combination of two oral chelators deferasirox/deferiprone over deferoxamine/deferipronre in severely iron‐overloaded young beta thalassemia major patients
Conclusionboth iron chelation combination regimens were equally effective in reducing iron overload and improving QoL.DFP/DFX combination proved superior in improving cardiac T2*,treatment compliance and patients satisfaction with no greater adverse events.This article is protected by copyright. All rights reserved. (Source: European Journal of Haematology)
Source: European Journal of Haematology - January 21, 2015 Category: Hematology Authors: Elalfy, A M Adly, Y Wali, S Tony, A Samir, Y Elhenawy Tags: Original Article Source Type: research

Postprandial Hyperinsulinaemic Hypoglycaemia Secondary to a Congenital Portosystemic Shunt
Conclusion: PSS can rarely be associated with HH, possibly due to lack of insulin degradation in the liver. Surgical closure of the shunt resolves the hypoglycaemia.Horm Res Paediatr (Source: Hormone Research in Paediatrics)
Source: Hormone Research in Paediatrics - January 21, 2015 Category: Endocrinology Source Type: research

Close monitoring of renal tumors may provide alternative to surgery
(The Mount Sinai Hospital / Mount Sinai School of Medicine) In patients likely to have surgery, close, active monitoring of small renal tumors confined to the kidneys is associated with low rates of tumor growth or death. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 21, 2015 Category: Cancer & Oncology Source Type: news

PREMIER VALUE FLU RELIEF (Cairina Moschata Heart/Liver Autolysate) Pellet [CHAIN DRUG CONSORTIUM LLC]
Updated Date: Jan 21, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 21, 2015 Category: Drugs & Pharmacology Source Type: news

Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma.
Authors: Chang CH, Chan PC, Li JR, Chen CJ, Shieh JJ, Fu YC, Chen HC, Wu MJ Abstract Urothelial carcinoma is the most common type of malignancy in long-term dialysis patients and kidney transplant recipients in Taiwan. mTORCs (mammalian target of rapamycin complexes) and EGF are important in urothelial carcinoma. To identify the regulation of mTORCs upon EGF stimulation is necessary. mTOR integrates signals from growth factors via mTOR Complex 1 (mTORC1) and mTOR Complex 2 (mTORC2). The mechanism of mTORC1 action has been widely studied; however, the regulation of mTORC2 has not been well studied. Here, we demonstr...
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Cyclin alterations in diverse cancers: Outcome and co-amplification network.
Authors: Schwaederlé M, Daniels GA, Piccioni DE, Fanta PT, Schwab RB, Shimabukuro KA, Parker BA, Kurzrock R Abstract Cyclin genes are key regulatory components of the cell cycle. With the development of new agents, cyclin-related genes are becoming increasingly important as they can be targeted. Yet, the biological implications of these alterations have not been fully studied. Clinical characteristics and outcome parameters were compared for patients harboring cyclin alterations versus not. CCN alterations were found in 13% of our population (50/392; all amplifications) and were associated with breast cancer (P &l...
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The inverse relationship between bladder and liver in 4-aminobiphenyl-induced DNA damage.
Authors: Bhattacharya A, Klaene JJ, Li Y, Paonessa JD, Stablewski AB, Vouros P, Zhang Y Abstract Bladder cancer risk is significantly higher in men than in women. 4-Aminobiphenyl (ABP) is a major human bladder carcinogen from tobacco smoke and other sources. In mice, male bladder is more susceptible to ABP-induced carcinogenesis than female bladder, but ABP is more carcinogenic in the livers of female mice than of male mice. Here, we show that castration causes male mice to acquire female phenotype regarding susceptibility of bladder and liver to ABP. However, spaying has little impact on organ susceptibility to AB...
Source: Oncotarget - January 21, 2015 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Hospital-based inpatient resource utilization associated with autosomal dominant polycystic kidney disease in the US
Journal of Medical Economics, Ahead of Print. (Source: Journal of Medical Economics)
Source: Journal of Medical Economics - January 21, 2015 Category: Health Management Tags: article Source Type: research

99mTc-octreotide Receptor Scintigraphy in NCI-H446 Small Cell Lung Cancer Nude Mice Model
Background and objective For highly aggressive small cell lung cancer (SCLC), early diagnosis is important for its prognosis, but the current inspection methods are more limited, with poor specificity of the traditional imaging methods, and the high cost of PET/CT, difficult to popularization and application. SCLC is kind of neuroendocrine tumors, high expression of somatostatin receptors, which is the cornerstone of its early molecular imaging diagnosis. The aim of this study is to observe the biodistribution and metabolism of 99mTc-octreotide in normal and the human SCLC bearing nude mice. Methods Dynamic and static scin...
Source: Chinese Journal of Lung Cancer - January 21, 2015 Category: Cancer & Oncology Source Type: research

Neutrophil extracellular trap formation is associated with autophagy‐related signaling in ANCA‐associated vasculitis
This article is protected by copyright. All rights reserved. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - January 21, 2015 Category: Allergy & Immunology Authors: Sha Tang, Ying Zhang, Shiwei Yin, Xuejing Gao, Weiwei Shi, Yuan Wang, Xing Huang, Li Wang, Liyun Zou, Jinghong Zhao, Yunjian Huang, Lianyu Shan, Abdelilah S. Gounni, Yuzhang Wu, Jingbo Zhang Tags: Original Article Source Type: research

A validated liquid chromatography tandem mass spectrometry method for quantification of erlotinib, OSI-420 and didesmethyl erlotinib and semi-quantification of erlotinib metabolites in human plasma
Publication date: 25 March 2015 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 107 Author(s): Anna Svedberg , Henrik Gréen , Anders Vikström , Joakim Lundeberg , Svante Vikingsson A liquid chromatography tandem mass spectrometry method was developed and validated for quantification of erlotinib and its metabolites in human plasma. The method is suitable for therapeutic drug monitoring and pharmacokinetic studies. The substances were extracted using protein precipitation, separated on a BEH XBridge C18 column (100×2.1mm, 1.7μm) by gradient elution at 0.7mL/min of acetonitrile and 5mM ammonium acetate...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 21, 2015 Category: Drugs & Pharmacology Source Type: research

Renal function during long-term lithium treatment: a cross-sectional and longitudinal study
Duration of lithium therapy is associated with reduced kidney function regardless of subsequent discontinuation once kidneys are already damaged, suggesting that kidney risk should be weighed against lithium’s beneficial effects for mood disorders.  (Source: BioMed Central)
Source: BioMed Central - January 21, 2015 Category: Journals (General) Authors: Alberto BocchettaRaffaella ArdauTiziana FanniClaudia SarduDoloretta PirasAntonello PaniMaria Del Zompo Source Type: research

Expression of parathyroid hormone/parathyroid hormone-related peptide receptor 1 in normal and diseased bladder detrusor muscles: a clinico-pathological study
Conclusions: Downregulation of PTH1R may be involved in the pathogenesis of human end-stage bladder disease requiring augmentation. (Source: BioMed Central)
Source: BioMed Central - January 21, 2015 Category: Journals (General) Authors: Nobuyuki NishikawaRie YagoYuichiro YamazakiHiromitsu NegoroMari SuzukiMasaaki ImamuraYoshinobu TodaKazunari TanabeOsamu OgawaAkihiro Kanematsu Source Type: research

A weekly alternating diet between caloric restriction and medium fat protects the liver from fatty liver development in middle‐aged C57BL/6J mice
ConclusionsOur study reveals that the INT diet maintains metabolic health and reverses the adverse effects of the MF diet, thus effectively prevents the development of NAFLD in 12‐month‐old male C57BL/6J mice. (Source: Nahrung / Food)
Source: Nahrung / Food - January 21, 2015 Category: Nutrition Authors: Fenni Rusli, Mark V. Boekschoten, Arantza Aguirre Zubia, Carolien Lute, Michael Müller, Wilma T. Steegenga Tags: Research Article Source Type: research

Coeliac‐like duodenal pathology in orthotopic liver transplant patients on mycophenolic acid therapy
ConclusionsPathologists should be aware of the features of MPA‐associated duodenal injury, including coeliac‐like changes and increased apoptotic counts. In those with abnormal histology, discontinuation or a reduction in the dose of MPA should be discussed. (Source: Histopathology)
Source: Histopathology - January 21, 2015 Category: Pathology Authors: Maura B Cotter, Ahmed AbuShanab, Raphael Merriman, Aiden McCormick, Kieran Sheahan Tags: Original Article Source Type: research

Bones, stones, moans and groans: hypercalcaemia revisited
We report a 4-year-old with acute onset profound hypercalcaemia. We focus on an approach to the clinical problem that is based on the potential organ systems affected, namely the gut, bone and kidney. Key biochemical parameters that may help the paediatric team to reach a diagnosis are discussed, as well as important components of acute management. (Source: Archives of Disease in Childhood - Education and Practice)
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Reynolds, B. C., Cheetham, T. D. Tags: Calcium and bone, Metabolic disorders Problem solving in clinical practice Source Type: research

Antibiotic prophylaxis reduced symptomatic urinary tract infection in children with vesicoureteral reflux, but not scarring
Design: Randomised controlled trial. Allocation: Computer-generated permuted block stratified randomisation done by a centralised data-coordinating centre. Blinding: Caregivers as well as physicians were blinded. Study question Setting: Nineteen sites in a variety of clinical settings in the USA. Patients: Six hundred and seven children, 2–71 months old, with vesicoureteral reflux (VUR) grades I–IV, recruited after their first or second urinary tract infection (UTI). Intervention: Patients received either 3 mg/kg trimethoprim plus 15 mg/kg of sulfamethoxazole daily or an identical placebo. Outcom...
Source: Archives of Disease in Childhood - Education and Practice - January 21, 2015 Category: Pediatrics Authors: Perez-Gaxiola, G. Tags: Urology, Journalology, Clinical trials (epidemiology), Drugs: infectious diseases, Urinary tract infections, Child health, Urinary tract infections, Competing interests (ethics) Picket Source Type: research

AM-Pharma begins Phase II trial of recAP to treat acute kidney injury
Dutch biopharmaceutical firm AM‐Pharma has started its Phase II trial of recAP (recombinant human Alkaline Phosphatase) to treat sepsis-associated acute kidney injury (AKI). (Source: Drug Development Technology)
Source: Drug Development Technology - January 21, 2015 Category: Pharmaceuticals Source Type: news

Multicentric study on 18F-FDG-PET/CT breast incidental uptake in patients studied for non-breast malignant purposes
Conclusions Our multicenter study demonstrates that, although they are uncommon, BIUs show a high percentage of malignancy and therefore requires further research. (Source: Revista Espanola de Medicina Nuclear e Imagen Molecular)
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - January 21, 2015 Category: Radiology Source Type: research

Changes in Echocardiographic Parameters in Iron Deficiency Patients with Heart Failure and Chronic Kidney Disease Treated with Intravenous Iron
Treatment of iron deficiency helps to improve cardiac and renal function in patients with chronic heart failure. However, the mechanism by which this occurs is currently unclear. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - January 21, 2015 Category: Cardiology Authors: Jorge E Toblli, Federico Di Gennaro, Carlos Rivas Source Type: research

Accredited translational medicine centre Human renal fibrotic disease: Translational research at the Center for Cell Biology and Cancer Research (CCBCR), Albany Medical College, Albany, NY
Publication date: January 2015 Source:New Horizons in Translational Medicine, Volume 2, Issue 2 Author(s): Paul J. Higgins , Aamir Shahzad , Jeffrey Kennedy Translational studies conducted in the Center for Cell Biology & Cancer Research at the Albany Medical College integrate the discovery of basic mechanisms underlying the development of human fibrotic disease with in vivo interventional strategies and tissue repair outcomes in animal models. This structured research program is expected to lead to the clinical adaptation of novel therapies specifically directed to the control of pathologically-relevant profibro...
Source: New Horizons in Translational Medicine - January 21, 2015 Category: Research Source Type: research

The Clinical Characters of Congenital Choledochal Cysts in Perinatal Patients: A Retrospective Analysis in a Single Institution
Conclusion Abdominal pain, jaundice, inflammatory markers, and liver function in perinatal patients with CC are better than in the infancy and childhood groups. We recommend surgical treatment before 120 days of age.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents  |  Abstract  |  Full text (Source: American Journal of Perinatology)
Source: American Journal of Perinatology - January 21, 2015 Category: Perinatology & Neonatology Authors: Tang, WeitaoDong, KuiranLiu, GongbaoCui, XimaoZheng, Shan Tags: Original Article Source Type: research

Development of Lipoprotein(a) siRNAs for Mechanism of Action Studies in Non-Human Primate Models of Atherosclerosis
We describe targeting of LPA using lipid nanoparticle formulated short interfering RNAs (siRNAs) in lean rhesus macaque monkeys. We show >90 % LPA mRNA lowering in the liver and >95 % Lp(a) plasma reduction for over 3 weeks after a single siRNA dose. Given the potency of LPA siRNAs, siRNA approach may enable chronic reduction of Lp(a) in atherosclerotic NHP and help to unmask the role for Lp(a) in the genesis and progression of atherosclerosis in man. (Source: Journal of Cardiovascular Translational Research)
Source: Journal of Cardiovascular Translational Research - January 21, 2015 Category: Cardiology Source Type: research

Gender impact on the correlations between subclinical thyroid dysfunction and hyperuricemia in Chinese
This study aimed to investigate the association between subclinical thyroid disorders and hyperuricemia with emphasized focuses on differences resulting from different gender. Eleven thousand four hundred forty-six healthy subjects (6870 male, 4576 female) were enrolled in this cross-sectional study, with exclusions of known thyroid, renal, hepatic, gastrointestinal, or oncological diseases. Clinical data including anthropometric measurements, thyroid function, uric acid, renal and liver function were collected. The associations between thyroid function and hyperuricemia of males and females were analyzed separately. Preva...
Source: Clinical Rheumatology - January 21, 2015 Category: Rheumatology Source Type: research

Safety and Accuracy of Endovascular Aneurysm Repair Without Pre-operative and Intra-operative Contrast Agent
Severe chronic kidney disease is a major limitation for endovascular aortic aneurysm repair (EVAR). The aim of this study is to assess the safety and accuracy of fusion imaging, when performing EVAR in the absence of pre- and intra-operative contrast agents. (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - January 21, 2015 Category: Surgery Authors: A. Kaladji, A. Dumenil, G. Mahé, M. Castro, A. Cardon, A. Lucas, P. Haigron Source Type: research

The Race to Liver Transplant: A Comparison of Patients With and Without Hepatocellular Carcinoma from Listing to Post-Transplant
Prolonged liver transplant wait times have allowed for a longitudinal comparison between hepatocellular carcinoma (HCC) and non-HCC candidates. Despite waiting longer, HCC recipients have excellent survival and less waitlist removals than non-HCC candidates. Reprioritization of allocation from HCC candidates to non-HCC candidates is warranted. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - January 21, 2015 Category: Surgery Authors: Madhukar S. Patel, Rachel Kohn, Johannes R. Kratz, Jigesh A. Shah, James F. Markmann, Parsia A. Vagefi Source Type: research

Causes of death in men with localised prostate cancer: a nationwide, population‐based study
ConclusionsMen with low‐risk PCa had lower all‐cause mortality than PCa‐free men due to lower cardiovascular mortality, driven by early detection selection. However, for men with intermediate or high‐risk disease, PCa death was substantial, irrespective of CCI, and this was even more pronounced for those diagnosed at age 50 or 60. (Source: BJU International)
Source: BJU International - January 21, 2015 Category: Urology & Nephrology Authors: Mieke Van Hemelrijck, Yasin Folkvaljon, Jan Adolfsson, Olof Akre, Lars Holmberg, Hans Garmo, Pär Stattin Tags: Translational Science Source Type: research

Transrectal ultrasonography (TRUS)‐guided pelvic plexus block to reduce pain during prostate biopsy: a randomised controlled trial
ConclusionPPB is superior to conventional periprostatic nerve block (PNB) for pain control during TRUS‐guided biopsy and both are in turn superior to no nerve block. (Source: BJU International)
Source: BJU International - January 21, 2015 Category: Urology & Nephrology Authors: Tarun Jindal, Subhabrata Mukherjee, Rajan K. Sinha, Mir R. Kamal, Nabankur Ghosh, Barun Saha, Nilanjan Mitra, Pramod K. Sharma, Soumendra N. Mandal, Dilip Karmakar Tags: Urological Oncology Source Type: research

Ureteroscopy for stone disease in the paediatric population: a systematic review
The aim of the present review was to look at the role of ureteroscopy (URS) for treatment of paediatric stone disease. We conducted a systematic review using studies identified by a literature search between January 1990 and May 2013. All English‐language articles reporting on a minimum of 50 patients aged ≤18 years treated with URS for stone disease were included. Two reviewers independently extracted the data from each study. A total of 14 studies (1718 procedures) were reported in patients with a mean (range) age of 7.8 (0.25–18.0) years. The mean (range) stone burden was 9.8 (1–30) mm and the mean (range) stone...
Source: BJU International - January 21, 2015 Category: Urology & Nephrology Authors: Hiro Ishii, Stephen Griffin, Bhaskar K. Somani Tags: Review Source Type: research