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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.

Could serum pentraxin 3 levels and IgM deposition in skin biopsies predict subsequent renal involvement in children with Henoch–Schönlein purpura?
Conclusions A high PTX3 level and IgM staining in skin biopsies from HSP patients may be harbingers of subsequent renal involvement. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Interdialytic weight gain in oligoanuric children and adolescents on chronic hemodialysis
Conclusions There is a significant correlation between IDWG and LVMI in pediatric oligoanuric patients on chronic HD: those with an IDWG of >4 % are at a higher risk of left ventricular hypertrophy. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Acidosis: progression of chronic kidney disease and quality of life
Abstract Metabolic acidosis (MA) is relatively common in patients with chronic kidney disease (CKD) particularly in stages 4 and 5. It is assumed to play a contributory role in the development of several complications including bone disease, skeletal muscle wasting, altered protein synthesis, and degradation. Recent evidence also suggests that even mild acidosis might play a role in progressive glomerular filtration rate loss. Experimental and clinical studies suggest that correction of acidosis by alkali therapy attenuates these complications and improves quality of life. Despite several recent small and single-...
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Unwrapping the origins and roles of the renal endothelium
Abstract The renal vasculature, like all vessels, is lined by a thin layer of simple squamous epithelial cells called an endothelium. These endothelial-lined vessels can be subdivided into four major compartments: arteries, veins, capillaries and lymphatics. The renal vasculature is a highly integrated network that forms through the active processes of angiogenesis and vasculogenesis. Determination of the precise contribution of these two processes and of the molecular signaling that governs the differentiation, specification and maturation of these critical cell populations is the focus of an actively evolving f...
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

A complicated case of atypical hemolytic uremic syndrome with frequent relapses under eculizumab
Conclusions Not every patient with aHUS and uncontrolled complement activation shows optimal therapeutic response to eculizumab with the recommended or even increased dosing regimen. Reliable outcome measures to determine the efficacy of treatment have to be defined. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury
Conclusions Our findings identify a major population of M2-type macrophages in patients with CAI, and suggest that these M2-type macrophages might promote the development of interstitial fibrosis in IF/TA-NOS. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

CRIT-LINE: a noninvasive tool to monitor hemoglobin levels in pediatric hemodialysis patients
Conclusions The CRIT-LINE monitor is an accurate instrument for monitoring Hgb levels in HD patients. Further studies will be needed to evaluate whether using CRIT-LINE Hgb levels to guide anemia management will improve the percentage of children with Hgb levels within target. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Outcomes associated with the use of renal replacement therapy in children receiving extracorporeal membrane oxygenation after heart surgery: a multi-institutional analysis
Conclusions We demonstrated worsening outcomes in children receiving ECMO with RRT compared to children receiving ECMO without RRT. Although the results could reflect confounding by severity of illness, they provide a rationale for prospective testing of use of RRT in critically ill children receiving ECMO with heart surgery. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Cystinosis: renal glomerular and renal tubular function in relation to compliance with cystine-depleting therapy
Conclusions Greater compliance with oral cysteamine therapy yields greater preservation of renal glomerular, but not tubular, function. Oral cysteamine therapy should be given at the maximum tolerated dose, within the recommended limits. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Risk factors for persistent proteinuria after a 2-year combination therapy for severe childhood IgA nephropathy
Conclusions In our cohort, urinary protein excretion and rate of glomeruli with crescents at diagnosis were independent risk factors for persistent proteinuria after the combination therapy. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

A rare cause of hypercalcemia: Answers
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients
Conclusions These data indicate that UAGT is a useful biomarker of intrarenal RAS activation, which is associated with glomerular injury during RAS blockade in pediatric IgAN patients. (Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Metabolomics in pediatric nephrology: emerging concepts
Abstract Metabolomics, the latest of the “omics” sciences, refers to the systematic study of metabolites and their changes in biological samples due to physiological stimuli and/or genetic modification. Because metabolites represent the downstream expression of genome, transcriptome, and proteome, they can closely reflect the phenotype of an organism at a specific time. As an emerging field in analytical biochemistry, metabolomics has the potential to play a major role in monitoring real-time kidney function and detecting adverse renal events. Additionally, small molecule metabolites can provide mechanistic i...
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

A rare cause of hypercalcemia: Questions
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

When listening for hoofbeats, sometimes there are zebras—an interesting case of a teenager with edema and high blood pressure: Questions
(Source: Pediatric Nephrology)
Source: Pediatric Nephrology - April 22, 2015 Category: Urology & Nephrology Source Type: research

Renal Cystic Disease and Liver Abnormalities: Polycystic Kidney and Hepatic Disease and the Association with Caroli Disease
We read with great interest the collective review article by Soares and colleagues entitled “Choledochal Cysts: Presentation, Clinical Differentiation, and Management,”1 in particular, the section dealing with type V choledochal cysts (Caroli disease) and hereditary polycystic kidney disease. Considering the important implications of this association, we would like to add some information that can help clarify the message in their article. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - April 22, 2015 Category: Surgery Authors: Armando J. Lorenzo, Damien Noone Tags: Letter Source Type: research

BHI FLU PLUS (Aconitum Napellus, Cairina Moschata Heart/Liver Autolysate, Bryonia Alba Whole, Eupatorium Perfoliatum Flowering Top, Ipecac, Lachesis Muta Venom,Phosphorus, Pulsatilla Vulgaris, Sulfur, Zinc Gluconate, And Zinc) Tablet [MediNatura Inc]
Updated Date: Apr 22, 2015 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - April 22, 2015 Category: Drugs & Pharmacology Source Type: news

Comprehensive and Quantitative Analysis of Lysophospholipid Molecular Species Present in Obese Mouse Liver by Shotgun Lipidomics
Analytical ChemistryDOI: 10.1021/acs.analchem.5b00410 (Source: Analytical Chemistry)
Source: Analytical Chemistry - April 22, 2015 Category: Chemistry Authors: Chunyan Wang, Miao Wang and Xianlin Han Source Type: research

Updates in liver disease research: Do you want the good or bad news?
(American Gastroenterological Association) The May issues of AGA's journals -- Clinical Gastroenterology and Hepatology and Gastroenterology -- highlight important research updates on the most deadly forms of liver disease. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 22, 2015 Category: Cancer & Oncology Source Type: news

Inflammatory bowel disease treatment gets boost from new educational resource
(Elsevier) A new educational resource for doctors and healthcare professionals will help improve knowledge and treatment of inflammatory bowel disease (IBD). The Inflammatory Bowel Disease Resource Centre was developed by Elsevier, the journal Digestive and Liver Disease, and was made possible through an educational grant from Ferring Pharmaceuticals. The Inflammatory Bowel Disease Resource Center is a free online platform designed to increase health-care professionals' knowledge of IBD. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 22, 2015 Category: Infectious Diseases Source Type: news

Toxic mushroom-based drug may help battle colorectal cancer
(University of Texas M. D. Anderson Cancer Center) For some time, cancer scientists have considered the toxin, alpha-amanatin derived from 'death cap' mushrooms, as a possible cancer treatment. However, due to its penchant for causing liver toxicity, its potential as an effective therapy has been limited. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 22, 2015 Category: Global & Universal Source Type: news

Different Patterns of Disease Spread between Advanced-Stage Type I and II Epithelial Ovarian Cancer
Conclusions: This study provides clinical evidence in favor of the dualistic model of carcinogenesis, since types I and II are characterized by different findings at primary surgery.Gynecol Obstet Invest (Source: Gynecologic and Obstetric Investigation)
Source: Gynecologic and Obstetric Investigation - April 22, 2015 Category: OBGYN Source Type: research

Life Is Not a Premortality Condition, and Death Is Not Treatment Failure
"Medical research is making such astounding progress that soon none of us will be well." --Aldous Huxley In my last blog post I discussed the importance of dying well and with dignity -- at home, at peace, sent off by a loving family, not in an impersonal and hectic hospital environment, among strangers, your failing body tortured by painful procedures and probed by ubiquitous tubes in a futile effort to cheat death. This week my issue is living well and without unnecessary fear of disease. Mark Cuban provides the perfect example of how excessive heath concerns are unhealthy. He is a brilliant Internet, entertainment, a...
Source: Science - The Huffington Post - April 22, 2015 Category: Science Source Type: news

Life Is Not a Premortality Condition, and Death Is Not Treatment Failure
"Medical research is making such astounding progress that soon none of us will be well." --Aldous Huxley In my last blog post I discussed the importance of dying well and with dignity -- at home, at peace, sent off by a loving family, not in an impersonal and hectic hospital environment, among strangers, your failing body tortured by painful procedures and probed by ubiquitous tubes in a futile effort to cheat death. This week my issue is living well and without unnecessary fear of disease. Mark Cuban provides the perfect example of how excessive heath concerns are unhealthy. He is a brilliant Internet, entertainment, a...
Source: Healthy Living - The Huffington Post - April 22, 2015 Category: Consumer Health Advice Source Type: news

Insights into the All-trans-Retinoic Acid and Arsenic Trioxide Combination Treatment for Acute Promyelocytic Leukemia: A Meta-Analysis
Conclusions: The ATRA + ATO combination therapy may be more effective for newly diagnosed APL with a higher CR rate but lower early mortality rate and relapse rate. However, the risks of liver damage should be of concern.Acta Haematol 2015;134:101-108 (Source: Acta Haematologica)
Source: Acta Haematologica - April 22, 2015 Category: Hematology Source Type: research

Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells
Abstract Iron homeostasis in the human body is maintained primarily through regulation of iron absorption in the duodenum. The liver peptide hepcidin plays a central role in this regulation. Additionally, expression and functional control of certain components of the cellular iron transport machinery can be influenced directly by the iron status of enterocytes. The significance of this modulation, relative to the effects of hepcidin, and the comparative effects of iron obtained directly from the diet and/or via the bloodstream are not clear. The studies described here were performed using Caco-2 cell monolaye...
Source: Genes and Nutrition - April 22, 2015 Category: Nutrition Source Type: research

Strategies for Avoiding Recommendations for Additional Imaging Through a Comprehensive Comparison with Prior Studies
Conclusions A small fraction of RAIs can be avoided by performing a thorough evaluation of all prior imaging examinations, including different modalities and body parts. Nearly half of the key prior examinations did not report the finding, highlighting the importance of directly reviewing relevant images, particularly chest imaging for evaluation of indeterminate upper-abdominal findings. Configuration of PACS for optimized selection and display of relevant examination reports and images may facilitate such comparisons. (Source: Journal of the American College of Radiology)
Source: Journal of the American College of Radiology - April 22, 2015 Category: Radiology Source Type: research

Objective assessment of health or pre-chronic disease state based on a health test index derived from routinely measured clinical laboratory parameters
ObjectiveTo develop a quantitative system to enable the objective assessment of health or pre-chronic disease state. Methods: On the basis of measured values and reference ranges, we obtained the organ function index (mean of the cut-off ratios of albumin and creatinine), blood lipid index (mean of the cut-off ratios of triglycerides, cholesterol, high-density lipoproteins and low-density lipoproteins), stress index (mean of the cut-off ratios of neutrophils and glucose), and the health test index (mean of the above three indexes, HTI). Elderly populations, individuals with nonalcoholic fatty liver disease and administrato...
Source: Journal of Translational Medicine - April 22, 2015 Category: Research Authors: Sun WenpingLiu YingLeng SongLi YuzhongLiu Hui Source Type: research

The FAT expandability (FATe) Project: Biomarkers to determine the limit of expansion and the complications of obesity
This study will also provide mechanistic evidence that promoting subcutaneous fat expansion might be a suitable therapy to reduce metabolic complications associated with positive energy balance characteristic of Westernized societies. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 22, 2015 Category: Cardiology Authors: Elena Torres-PerezMonica ValeroBeatriz Garcia-RodriguezYolanda Gonzalez-IrazabalPilar CalmarzaLuisa Calvo-RuataCarmen OrtegaMaria Garcia-SobrevielaAlejandro Sanz-ParisJose ArtigasJavier LagosJose Arbones-Mainar Source Type: research

Total tumor volume and alpha‐fetoprotein for selection of transplant candidates with hepatocellular carcinoma: A prospective validation
Conclusion: Based on the present prospective study, HCC LT candidate selection could be expanded to the TTV (≤115 cm3)/AFP (≤400 ng/mL) criteria in centers with at least 8‐month waiting time. An increased risk of dropout on the waiting list can be expected, but with equivalent and satisfactory post‐transplant survival. (Hepatology 2015) (Source: Hepatology)
Source: Hepatology - April 22, 2015 Category: Internal Medicine Authors: Christian Toso, Glenda Meeberg, Roberto Hernandez‐Alejandro, Jean‐François Dufour, Paul Marotta, Pietro Majno, Norman M. Kneteman Tags: Hepatobiliary Malignancies Source Type: research

Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C‐X‐C chemokine receptor 4 axis
Conclusion: MMP10 contributes to HCC development, participating in tumor angiogenesis, growth, and dissemination. We identified a new reciprocal crosstalk between MMP10 and the CXCR4/SDF1 axis contributing to HCC progression and metastasis. To our knowledge, this is the first report addressing the role of a MMP in hepatocarcinogenesis in the corresponding genetic mouse model. (Hepatology 2015) (Source: Hepatology)
Source: Hepatology - April 22, 2015 Category: Internal Medicine Authors: Oihane García‐Irigoyen, Maria U. Latasa, Simone Carotti, Iker Uriarte, Maria Elizalde, Raquel Urtasun, Umberto Vespasiani‐Gentilucci, Sergio Morini, Patricia Benito, Jose M. Ladero, Jose A. Rodriguez, Jesus Prieto, Josune Orbe, Jose A. Páramo, Maite Tags: Hepatobiliary Malignancies Source Type: research

Uncoupling, metabolic inhibition and induction of mitochondrial permeability transition in rat liver mitochondria caused by the major long-chain hydroxyl monocarboxylic fatty acids accumulating in LCHAD deficiency
Publication date: June–July 2015 Source:Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1847, Issues 6–7 Author(s): Fernanda Hermes Hickmann , Cristiane Cecatto , Daniele Kleemann , Wagner Oliveira Monteiro , Roger Frigério Castilho , Alexandre Umpierrez Amaral , Moacir Wajner Patients with long-chain 3-hydroxy-acyl-CoA dehydrogenase (LCHAD) deficiency commonly present liver dysfunction whose pathogenesis is unknown. We studied the effects of long-chain 3-hydroxylated fatty acids (LCHFA) that accumulate in LCHAD deficiency on liver bioenergetics using mitochondrial preparations from young rats. We provid...
Source: Biochimica et Biophysica Acta (BBA) Bioenergetics - April 22, 2015 Category: Biochemistry Source Type: research

Global gene expression profiling of telangiectasial tissue from patients with hereditary hemorrhagic telangiectasia
Publication date: Available online 16 April 2015 Source:Microvascular Research Author(s): Pernille M. Tørring , Martin Jakob Larsen , Anette D. Kjeldsen , Lilian Bomme Ousager , Qihua Tan , Klaus Brusgaard Hereditary hemorrhagic telangiectasia (HHT), the most common inherited vascular disorder, is predominantly caused by mutations in ENG and ACVRL1, which are part of the transforming growth factor beta (TGF-β) signaling pathway. HHT is characterized by the presence of mucocutaneous telangiectases and arteriovenous malformations in visceral organs, primarily the lungs, brain and liver. The most common symptom in HHT is ...
Source: Microvascular Research - April 22, 2015 Category: Biochemistry Source Type: research

Expression of Multidrug Resistance Protein 2 (mrp2) in the Liver and Kidney Cells of Female Rats with Modeled Cholestasis of Pregnancy
Using immunohistochemical method with semiquantitative analysis of images, we showed that mrp2 expression in response to cholestasis decreased in hepatocytes and cholangiocytes, and remained unchanged in the kidney structures. A decrease of mrp2 expression in renal tubules leading to a decrease of metabolic intoxication of the kidney was demonstrated in cholestasis of pregnancy model. In bile ducts cells, negative correlations of mrp2 with previously measured levels of prolactin receptors, CFTR, and mrp3 were revealed. In renal structures and in hepatocytes, no correlations were found between the expression of these protei...
Source: Bulletin of Experimental Biology and Medicine - April 22, 2015 Category: Biology Source Type: research