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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 12.
Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver.
Abstract The proliferation of biliary lineage cells in chronic liver diseases, which leads to formation of primitive ductules in portal areas of the hepatic lobule, may be important not only for liver regeneration, but also for initiation of liver cancer. Thus, understanding how these primitive ductular cells emerge and proliferate in chronically injured liver holds promise for development of therapeutic strategies for liver diseases. However, the origin of these primitive ductular cells remains controversial. We used genetic lineage tracing to determine the origin of cells that form primitive ductules in a mouse m...
Source: The American Journal of Pathology - March 1, 2014 Category: Pathology Authors: Sekiya S, Suzuki A Tags: Am J Pathol Source Type: research
Effect of quercetin against dichlorvos induced nephrotoxicity in rats.
This study was carried out to determine the effect of quercetin against renal injury induced by dichlorvos (DDVP) in rats. Rats were randomly assigned to control, DDVP-treated (7.2mg/kg bw), three different doses of quercetin-treated (2mg/kg bw, 10mg/kg bw, 50mg/kg bw) and different doses of quercetin plus DDVP-treated groups. DDVP was administered daily to rats through their drinking water, and quercetin was administered by intragastric gavage for 90 days. By the end of the 90th day in the DDVP-treated group, the following indices significantly increased compared with the control (P<0.01): activities of catalase, gluta...
Source: Experimental and Toxicologic Pathology - March 1, 2014 Category: Pathology Authors: Hou Y, Zeng Y, Li S, Qi L, Xu W, Wang H, Zhao X, Sun C Tags: Exp Toxicol Pathol Source Type: research
Treatment Satisfaction with Tadalafil or Tamsulosin versus Placebo in Men with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: Results from a Randomized, Placebo‐controlled Study
Conclusion● Treatment satisfaction was greater with tadalafil versus placebo, with no significant difference between tamsulosin and placebo. (Source: BJU International)
Source: BJU International - March 1, 2014 Category: Urology & Nephrology Authors: Matthias Oelke, François Giuliano, Simin K. Baygani, Thomas Melby, Angelina Sontag Tags: Functional Urology Source Type: research
Ancillary Personnel in Spanish and Latin-American Hospitals Faced With Living Related Kidney Donation.
CONCLUSIONS: The attitude toward living related kidney donation is favourable among ancillary personnel in Spanish and Latin-Americans hospitals. Because living donation is a better source of organs than cadaveric ones, this favourable predisposition can be used as promoting agent of living donation in order to develop it in Spanish-speaking countries. PMID: 24594399 [PubMed - as supplied by publisher] (Source: Actas Urologicas Espanolas)
Source: Actas Urologicas Espanolas - March 1, 2014 Category: Urology & Nephrology Authors: Ríos A, López-Navas A, Ayala-García MA, Sebastián MJ, Abdo-Cuza A, Martínez-Alarcón L, Ramírez EJ, Muñoz G, Suárez-López J, Castellanos R, Ramírez R, González B, Martínez MA, Díaz E, Ramírez P, Parrilla P Tags: Actas Urol Esp Source Type: research
Hemostasis in Chronic Kidney DiseaseHemostasis in Chronic Kidney Disease
How common are bleeding events in patients with impaired renal function receiving anticoagulant treatment, and how important is it for clinicians to carefully prescribe medications in patients with renal impairment? Nephrology Dialysis Transplantation (Source: Medscape Nephrology Headlines)
Source: Medscape Nephrology Headlines - February 28, 2014 Category: Urology & Nephrology Tags: Nephrology Journal Article Source Type: news
Cancer docs join forces
Physicians from Cancer Care Centers of Florida have joined Florida Cancer Affiliates, in a move that nearly doubles the number of doctors at FCA. Nine doctors from Cancer Care Centers – three radiation oncologists and six urologists – are now part of the FCA practice, which has 10 medical oncologists and one radiation oncologist. The practice will operate under the FCA name, a spokeswoman said. Florida Cancer Affiliates has locations in New Port Richey, Brooksville, Ocala and The Villages,… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - February 28, 2014 Category: Biotechnology Authors: Margie Manning Source Type: research
Evidence appraisal of Kaibori M, Matsui K, Ishizaki M, et al. A prospective randomized controlled trial of hemostasis with a bipolar sealer during hepatic transection for liver resection. Surgery. 2013;154(5):1046-1052.
Editor’s note: Reading research and incorporating valid research results into practice is a vital part of ensuring that perioperative nursing practice is evidence based. The AORN Research Evidence Appraisal Tool, which was adapted with permission from the Johns Hopkins Evidence-Based Practice Model and Guidelines, can help perioperative nurses evaluate research. This tool is used to evaluate the evidence upon which AORN’s recommended practices are based. The tool can be used to appraise the level of evidence and quality of evidence for a single research study or a summary of multiple research studies. An abbreviated t...
Source: AORN Journal - February 28, 2014 Category: Nursing Authors: George Allen Tags: Evidence for Practice Source Type: research
Long-term study confirms success of method for detecting spread of deadly skin cancer
Research at UCLA on a technique for detecting the earliest spread of melanoma, the deadliest form of skin cancer, has confirmed that the procedure significantly prolongs patients' survival rates compared with traditional "watch and wait" techniques. The technique, which combines lymphatic mapping and sentinel-node biopsy, allows doctors to quickly determine whether the disease has spread, or metastasized, to the lymph nodes, which occurs in approximately 20 percent of patients. Patients with cancer in their lymph nodes may benefit from having their other nearby lymph nodes removed. For the other approximately 80 per...
Source: UCLA Newsroom: Health Sciences - February 28, 2014 Category: Universities & Medical Training Source Type: news
Liver transplant for congenital factor VII deficiency
We report a patient with congenital FVII deficiency and recurrent ICH, despite twice‐weekly prophylaxis with recombinant activated FVII. At 17 months of age, he underwent an orthotopic liver transplant. He is now 1‐year post‐transplant, on maintenance immunosuppression with no hemorrhage or other complications. Pediatr Blood Cancer 2014;9999:1–2. © 2014 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 28, 2014 Category: Cancer & Oncology Authors: Melissa A. Acquazzino, Eric T. Rush, Ruben E. Quiros Tejeira, Jill C. Beck Tags: Brief Report Source Type: research
CD49b, a Major Marker of Regulatory T-Cells Type 1, Predicts the Response to Antiviral Therapy of Recurrent Hepatitis C after Liver Transplantation.
Abstract The TRANSPEG study was a prospective study to assess the efficacy of antiviral therapy in patients with a recurrent hepatitis C virus (HCV) after liver transplantation. The influence of regulatory T-cells (Tregs) on the response to antiviral therapy was analyzed. Patients were considered as a function of their sustained virological response (SVR) at 18 months after treatment initiation. A transcriptomic analysis was performed to assess Treg markers (Tr1 and FoxP3(+)) in serum, PBMC, and liver biopsies. 100 patients had been included in the TRANSPEG study. Data from 27 of these patients were available. The ...
Source: Biomed Res - February 28, 2014 Category: Research Authors: Fabien S, Olivier M, Khaldoun G, Vivian V, Lynda A, Laurissa O, Gautier G, Yvon C, Nadira D, Filomena C Tags: Biomed Res Int Source Type: research
Construction of a novel liver-targeting fusion interferon by incorporation of a Plasmodium region I-plus Peptide.
Abstract Interferon alpha (IFN α ) exerts a multiplicity of biological actions including antiviral, immunomodulatory, and antiproliferative effects. Administration of IFN α is the current treatment for chronic hepatitis B; however, therapy outcome has not been completely satisfactory. The systemic effects of IFN α may account for its low in vivo biological activity and multiple adverse events. The purpose of this study was to design a novel liver-targeting fusion interferon (IFN-CSP) by fusing IFN α 2b with a Plasmodium region I-plus peptide, thus targeting the drug specifically to the liver. The DNA sequence e...
Source: Biomed Res - February 28, 2014 Category: Research Authors: Lu X, Jin X, Huang Y, Wang J, Shen J, Chu F, Mei H, Ma Y, Zhu J Tags: Biomed Res Int Source Type: research
Unusual genetic mutation found linked to adolescent liver cancer
In the race for better treatments and possible cures, rare diseases are often left behind. Through a collaboration of researchers, an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. The research suggests that the mutation plays a key role in the development of the disease, called fibrolamellar hepatocellular carcinoma, and may also underlie more common cancers as well. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 28, 2014 Category: Science Source Type: news
Pacific cod: the other codfish | @GrrlScientist
A poetic intersection between life and science, art and photography.After stumbling across Adam Summers' work a few months ago, I purchased a few of his calendars as holiday gifts. The calendars -- which are beautifully photographed and sturdily made -- show the fish but lack any information about them and unfortunately, the poetry is lacking as well. That gave me the idea that I should publish each month's photograph here, along with the poem and some relevant information. Professor Summers liked the idea, and poet Sierra Nelson kindly agreed to share her poetry along with each fish photograph.For the month of February, t...
Source: Guardian Unlimited Science - February 28, 2014 Category: Science Authors: GrrlScientist Tags: theguardian.com Blogposts Photography Art Fishing Animals Zoology Environment Science Source Type: news
Neurologic status at surgery affects metastatic spinal renal cell carcinoma survival
Neurological status at surgery, the grade of the original nephrectomy specimen and activity of the systemic disease were factors found to influence a patient’s survival after spine surgery for metastatic spinal renal cell carcinoma...02/28/2014 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 28, 2014 Category: Cancer & Oncology Source Type: news
PolySia‐NCAM modulates the formation of ductular reactions in liver injury
Conclusion: We conclude that polySia modification of NCAM+ ductules weakens cell‐cell and cell‐matrix interactions allowing DRs/HPCs to migrate for normal development and regeneration. Modulation of polySia levels may provide a therapeutic option in liver regeneration. (Hepatology 2014;) (Source: Hepatology)
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: Atsunori Tsuchiya, Wei‐Yu Lu, Birgit Weinhold, Luke Boulter, Benjamin M Stutchfield, Michael J Williams, Rachel V Guest, Sarah E Minnis‐Lyons, Alison C MacKinnon, David Schwarzer, Takafumi Ichida, Minoru Nomoto, Yutaka Aoyagi, Rita Gerardy‐Schahn, S Tags: Liver Injury and Regeneration Source Type: research
Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testis
Summary To assess the protective effects of Eugenia jambolana extract (EJE) or N‐acetyl cysteine (NAC) on testis, cisplatin (CIS, 5 mg kg−1 bw, single dose) was administered either alone or along with EJE (25 mg kg−1 bw, alternate day) or NAC (150 mg kg−1 bw, Day 1 and 4) for 7 days. Significant alterations in serum LH, FSH and testosterone were observed in CIS group which were effectively modulated by EJE or NAC supplementation. Upregulation of 3β‐HSD gene indicated the rise in functional Leydig cells. This was further confirmed from the identical improvement in hCG‐stimulated testosterone production i...
Source: Andrologia - February 28, 2014 Category: Urology & Nephrology Authors: H. Anand, M. M. Misro, S. B. Sharma, S. Prakash Tags: Original Article Source Type: research
Eighteen cases of liver injury following ingestion of Polygonum multiflorum - Dong H, Slain D, Cheng J, Ma W, Liang W.
OBJECTIVES: Polygonum multiflorum is a popular Chinese herbal medication. In this case series, we report on 18 otherwise healthy non-viral hepatitis patients who developed liver dysfunction following consumption of P. multiflorum alone. METHODS: Concurrent... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - February 28, 2014 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news
miR‐181a mediates TGF‐β induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer.
ConclusionsMiR‐181a had a direct effect in inducing hepatocyte EMT and was able to replace TGF‐β induced effects in vitro. MiR‐181a was over‐expressed in cirrhosis and HCC and is likely to play a role in disease pathogenesis.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Jennifer Brockhausen, Szun S Tay, Candice A Grzelak, Patrick Bertolino, David G Bowen, William M d'Avigdor, Narcy Teoh, Sharon Pok, Nick Shackel, Jenny Gamble, Mathew Vadas, Geoff W McCaughan Tags: Original Article Source Type: research
Addressing the high failure rate of lung transplants
Organ transplant patients routinely receive drugs that stop their immune systems from attacking newly implanted hearts, livers, kidneys or lungs, which the body sees as foreign.But new research at Washington University School of Medicine in St. Louis suggests that broadly dampening the immune response, long considered crucial to transplant success, may encourage lung transplant rejection. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2014 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news
Fructose not responsible for increase in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease is the most common chronic liver disease in developed countries, affecting up to 30 per cent of their populations.Since the disease is closely linked to obesity and Type 2 diabetes, there's a growing debate in the medical community about whether diet plays a role in its development, specifically the consumption of fructose. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2014 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news
UCLA study finds robotic-assisted prostate surgery offers better cancer control
An observational study from UCLA's Jonsson Comprehensive Cancer Center has found that prostate cancer patients who undergo robotic-assisted prostate surgery have fewer instances of cancer cells at the edge of their surgical specimen and less need for additional cancer treatments like hormone or radiation therapy than patients who have traditional "open" surgery. The study, published online Feb. 19 in the journal European Urology, was led by Dr. Jim Hu, UCLA's Henry E. Singleton Professor of Urology and director of robotic and minimally invasive surgery in the urology department at the David Geffen School of Medicine...
Source: UCLA Newsroom: Health Sciences - February 28, 2014 Category: Universities & Medical Training Source Type: news
Three-Dimensional Reconstruction Volume: A Novel Method for Volume Measurement in Kidney Cancer
Journal of Endourology , Vol. 0, No. 0. (Source: Journal of Endourology)
Source: Journal of Endourology - February 28, 2014 Category: Urology & Nephrology Tags: article Source Type: research
Assessment of risk factors and test performance on malnutrition prevalence at admission using four different screening tools.
Conclusions: Undernourishment at hospital admission is frequent. Comorbidities may contribute to the presence of undernutrition at admission. Nonetheless, SGA, NRS2002, MNA-SF or MUST can be used in our setting. PMID: 24559014 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - February 28, 2014 Category: Nutrition Authors: Olivares J, Ayala L, Salas-Salvadó J, Muñiz MJ, Gamundí A, Martínez-Indart L, Masmiquel L L Tags: Nutr Hosp Source Type: research
Effect of probiotics on human blood urea levels in patients with chronic renal failure.
Conclusion: There was a > 10% decrease in the serum urea concentrations with LcS in patients with stage 3 and 4 CRF. PMID: 24559003 [PubMed - as supplied by publisher] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - February 28, 2014 Category: Nutrition Authors: Miranda Alatriste PV, Urbina Arronte R, Gómez Espinosa CO, Espinosa Cuevas MD Tags: Nutr Hosp Source Type: research
[Fructose consumption and its health implications; fructose malabsorption and nonalcoholic Fatty liver disease].
Conclusions: Fructose consumption has increased in recent decades, especially due to increased consumption of sweetened beverages and processed foods with added fructose. High fructose intake has been associated to pathologies as NAFLD and fructose malabsorption. PMID: 24558989 [PubMed - in process] (Source: Nutricion Hospitalaria)
Source: Nutricion Hospitalaria - February 28, 2014 Category: Nutrition Authors: Riveros MJ, Parada A, Pettinelli P Tags: Nutr Hosp Source Type: research
Researchers discover unusual genetic mutation linked to adolescent liver cancer
In the race for better treatments and possible cures, rare diseases are often left behind. In a collaboration of researchers at The Rockefeller University, Memorial Sloan Kettering Cancer Center and the New York Genome Center, an unusual mutation has been found that is strongly linked to one such disease: a rare liver cancer that affects teens and young adults. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - February 28, 2014 Category: Biomedical Science Authors: pubaff Tags: Science News Source Type: news
Current Status and Effectiveness of Mentorship Programmes in Urology – A Systematic Review
The objectives of this review are to identify and evaluate the efficacy of mentorship programmes for minimally invasive procedures in urology and give recommendations on how to improve mentorship. A systematic literature search of the PubMed/Medline databases was carried out according to the PRISMA guidelines. In total, 21 articles were included in the review and divided into 4 categories: fellowships, mini‐fellowships, mentored skills courses and novel mentorship programmes. Various structures of mentorship programme were identified and in general, mentorship programmes were found to be feasible, having content validity...
Source: BJU International - February 28, 2014 Category: Urology & Nephrology Authors: Daniel Hay, Mohammed Shamim Khan, Hendrik Van Poppel, Ben Van Cleynenbreugel, James Peabody, Khurshid Guru, Ben Challacombe, Prokar Dasgupta, Kamran Ahmed Tags: Review Source Type: research
[Report] Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma
A rare form of liver cancer affecting young adults expresses a chimeric kinase that may contribute to pathogenesis. Authors: Joshua N. Honeyman, Elana P. Simon, Nicolas Robine, Rachel Chiaroni-Clarke, David G. Darcy, Irene Isabel P. Lim, Caroline E. Gleason, Jennifer M. Murphy, Brad R. Rosenberg, Lydia Teegan, Constantin N. Takacs, Sergio Botero, Rachel Belote, Soren Germer, Anne-Katrin Emde, Vladimir Vacic, Umesh Bhanot, Michael P. LaQuaglia, Sanford M. Simon (Source: Science: Current Issue)
Source: Science: Current Issue - February 28, 2014 Category: Science Authors: Joshua N. Honeyman Source Type: research
Reappraisal of Serum Alpha‐fetoprotein as a Surveillance Test for Hepatocellular Carcinoma during Entecavir Treatment
ConclusionsThe role of serum AFP as a surveillance test should be re‐evaluated in patients with HBV‐related chronic liver diseases who were treated with antiviral therapy.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Gi‐Ae Kim, Chang Hyeon Seock, Jang Won Park, Jihyun An, Kwang‐Sun Lee, Jee Eun Yang, Young‐Suk Lim, Kang Mo Kim, Ju Hyun Shim, Danbi Lee, Han Chu Lee Tags: Original Article Source Type: research
How Can the IL28B Polymorphisms with Linkage Disequilibrium Affect the Natural Course of Hepatitis B Inversely?
This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Maryam Keshvari, Seyed Moayed Alavian, Heidar Sharafi Tags: Letter Source Type: research
Acetaminophen‐induced liver injury in obesity and nonalcoholic fatty liver disease
This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Anaïs Michaut, Caroline Moreau, Marie‐Anne Robin, Bernard Fromenty Tags: Reviews Source Type: research
Prevalence of photosensitivity in chronic hepatitis C virus patients and its relation to serum and urinary porphyrins
ConclusionAsymptomatic chronic HCV infection cases showed significantly high prevalence of photosensitivity which is related to the associated disturbance of porphyrins metabolism. Photosensitivity can thus be considered an early marker of HCV infection. Patients discovered to have recently acquired photosensitivity should be screened for HCV infection especially in endemic areas like Egypt.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Serag Esmat, Dina Elgendy, Mohamed Ali, Samia Esmat, Eman A. El‐Nabarawy, Sara Bahaa Mahmoud, Olfat Shaker Tags: Original Article Source Type: research
Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure
ConclusionsSimilar to its prognostic properties in patients with sepsis or liver cirrhosis, intrahepatic uPAR activation and serum suPAR concentrations might serve as an interesting biomarker in ALF.This article is protected by copyright. All rights reserved. (Source: Liver International)
Source: Liver International - February 28, 2014 Category: Gastroenterology Authors: Alexander Koch, Henning W. Zimmermann, Nikolaus Gassler, Christoph Jochum, Ralf Weiskirchen, Jan Bruensing, Lukas Buendgens, Hanna Dückers, Tony Bruns, Guido Gerken, Ulf Peter Neumann, David H. Adams, Christian Trautwein, Ali Canbay, Frank Tacke Tags: Original Article Source Type: research
Isolation and sequencing of swine carbonic anhydrase VI, an enzyme expressed in the swine kidney
Conclusions: The localisation of CA-VI indicates that it may play a specialised role in the kidney. (Source: BioMed Central)
Source: BioMed Central - February 28, 2014 Category: Journals (General) Authors: Toshiho NishitaJuro YatsuMasaru MurakamiShino KamoshidaKensuke OritoNobutune IchiharaKazuyoshi ArishimaHideharu Ochiai Source Type: research
Bufalin attenuates the stage and metastatic potential of hepatocellular carcinoma in nude mice
Conclusion: Based on the above, one can draw conclusions that bufalin has significant anti-tumor activities and reduces the metastatic potential in an orthotopic transplantation tumor model of human HCC. Inhibition of AKT/GSK3beta/beta-catenin/E-cadherin signaling pathways by bufalin may show therapeutic effects in advanced HCC patients. (Source: Journal of Translational Medicine)
Source: Journal of Translational Medicine - February 28, 2014 Category: Research Authors: Zhou-Ji ZhangYun-Ke YangWei-Zhong Wu Source Type: research
Late HDV RNA relapse after peginterferon alfa‐based therapy of chronic hepatitis delta
Conclusions: Late HDV RNA relapses may occur after PEG‐IFNa therapy of hepatitis delta and thus the term SVR should be avoided in HDV infection. The annual post‐treatment rate of clinical events in hepatitis delta patients eligible for PEG‐IFNa therapy is about 2.5% and 4.9% in patients with cirrhosis. (Hepatology 2014;) (Source: Hepatology)
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: Benjamin Heidrich, Cihan Yurdaydın, Gökhan Kabaçam, Boris A. Ratsch, Kalliopi Zachou, Birgit Bremer, George N. Dalekos, Andreas Erhardt, Fehmi Tabak, Kendal Yalcin, Selim Gürel, Stefan Zeuzem, Markus Cornberg, C.‐Thomas Bock, Michael P. Manns, Heine Tags: Viral Hepatitis Source Type: research
Treatment of phenylketonuria using minicircle‐based naked‐DNA gene transfer to murine liver
Conclusion: This study demonstrates that MC technology offers an improved safety profile and has the potential for the genetic treatment of liver diseases. (Hepatology 2014;) (Source: Hepatology)
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: Hiu Man Viecelli, Richard P. Harbottle, Suet Ping Wong, Andrea Schlegel, Marinee K. Chuah, Thierry VandenDriessche, Cary O. Harding, Beat Thöny Tags: Liver Biology and Pathobiology Source Type: research
Reply to “The influence of Menopause on the Development of Hepatic Fibrosis in Non‐obese Women with Nonalcoholic Fatty Liver disease”
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: Ju Dong Yang, Ayako Suzuki Tags: Correspondence Source Type: research
Prevalence and natural history of histologically proven chronic liver disease in a longitudinal cohort of patients with type 1 diabetes
Conclusion: Type 1 diabetes is associated with a previously unrecognised burden of chronic liver disease and its complications. (Hepatology 2014;) (Source: Hepatology)
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: David John Harman, Philip Kaye, Rebecca Harris, Ayako Suzuki, Anastasios Gazis, Guruprasad Padur Aithal Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
The Influence of Menopause on the Development of Hepatic Fibrosis in Non‐obese Women with Nonalcoholic Fatty Liver Disease
Source: Hepatology - February 28, 2014 Category: Internal Medicine Authors: Masato Yoneda, Emmanuel Thomas, Yoshio Sumida, Yuichiro Eguchi, Eugene R Schiff Tags: Correspondence Source Type: research
Cohort Profile: The Boston Area Community Health (BACH) survey
The Boston Area Community Health (BACH) Survey is a community-based, random sample, epidemiologic cohort of n = 5502 Boston (MA) residents. The baseline BACH Survey (2002–05) was designed to explore the mechanisms conferring increased health risks on minority populations with a particular focus on urologic signs/symptoms and type 2 diabetes. To this end, the cohort was designed to include adequate numbers of US racial/ethnic minorities (Black, Hispanic, White), both men and women, across a broad age of distribution. Follow-up surveys were conducted ~5 (BACH II, 2008) and 7 (BACH III, 2010) years later, which allows f...
Source: International Journal of Epidemiology - February 28, 2014 Category: Epidemiology Authors: Piccolo, R. S., Araujo, A. B., Pearce, N., McKinlay, J. B. Tags: Cohort Profiles Source Type: research
Liver enzymes and risk of all-cause mortality in general populations: a systematic review and meta-analysis
Conclusions Available data indicate positive independent associations of baseline levels of GGT and ALP with all-cause mortality, consistent with linear dose-response relationships. There were geographical variations in the association of ALT with all-cause mortality which require further investigation. The potential incremental prognostic values of GGT and ALP in mortality risk assessment need evaluation. (Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - February 28, 2014 Category: Epidemiology Authors: Kunutsor, S. K., Apekey, T. A., Seddoh, D., Walley, J. Tags: Mortality Source Type: research
Commentary: Liver enzymes and all-cause mortality
(Source: International Journal of Epidemiology)
Source: International Journal of Epidemiology - February 28, 2014 Category: Epidemiology Authors: Fraser, A. Tags: Mortality Source Type: research
The Fli‐1 transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney
Abstract The transcription factor Fli‐1 is implicated in the pathogenesis of systemic lupus erythematosus in both human patients and murine models of lupus. MRL/lpr mice and NZM2410 mice, murine models of lupus, with decreased expression of Fli‐1 had significantly prolonged survival and reduced nephritis. Lupus nephritis is a major cause of mortality and morbidity in patients and inflammatory cell infiltration plays a key role in the development of the disease. To study how the expression of Fli‐1 affects the infiltration of inflammatory cells into the kidneys, we generated congenic enhanced green fluorescent protein...
Source: Clinical and Experimental Immunology - February 28, 2014 Category: Allergy & Immunology Authors: Shuzo Sato, Xian K. Zhang Tags: Original Article Source Type: research