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Prostatectomy modifications improve return of continence after surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Anterior suspension combined with posterior reconstruction during robotic-assisted laparoscopic prostatectomy significantly improves the early return of continence in patients after surgery, report researchers. (Source: MedWire News - Urology)
Source: MedWire News - Urology - February 3, 2012 Category: Urology & Nephrology Source Type: news

Dysregulation of circulating microRNAs and prediction of aggressive prostate canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONSThese preliminary data suggest that altered plasma miRNAs may be useful predictors to distinguish PCa patients with varied aggressiveness. Further larger studies to validate this promising finding are warranted. Prostate © 2012 Wiley Periodicals, Inc. (Source: The Prostate)
Source: The Prostate - February 3, 2012 Category: Urology & Nephrology Authors: Jing ShenGregory W. HrubyJames M. McKiernanIrina GurvichMichael Jeffrey LipskyMitchell C. BensonRegina M. Santella Tags: Original Article Source Type: research

Three‐dimensional tumour volume and cancer‐specific survival for patients undergoing nephrectomy to treat pT1 clear‐cell renal cell carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS• Tumour volume could provide valuable prognostic information for patients with pT1a ccRCC but not pT1b ccRCC.• Future investigations are needed to confirm this finding, explore other RCC subtypes and evaluate accuracy of tumour volume determination on radiographic imaging for potential patient management before surgery. (Source: BJU International)
Source: BJU International - February 3, 2012 Category: Urology & Nephrology Authors: Jacob JornsDavid D. ThielChristine M. LohseAdrienne WilliamsMichelle L. ArnoldJohn C. ChevilleBradley C. LeibovichAlexander S. Parker Source Type: research

Genotoxicity, cytotoxicity and toxicological evaluation of whole plant extracts of the medicinal plant Phyllanthus niruri (Phyllanthaceae).email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We examined the geno-, cyto- and overall toxicity of P. niruri whole plant ethanolic extract. The extract was administered as a single dose of 30 or 300 mg/kg to laboratory rats by gavage, accompanied by negative (0.9% saline) and positive (10 mg/mL N-ethyl-N-nitrosourea) controls that were injected intramuscularly 48 h after extract administration. The ratio of polychromatic (PCE)/normochromatic erythrocytes (NCE) from femur bone marrow was scored for genotoxicity. Cytotoxicity was determined using descending concentrations (0.2-0.0125 g/mL) of the extract incubated with peripheral blood mononuclear cells. Lactate dehydro...
Source: Genetics and Molecular Research - February 3, 2012 Category: Genetics & Stem Cells Authors: Asare GA, Bugyei K, Sittie A, Yahaya ES, Gyan B, Adjei S, Addo P, Wiredu EK, Adjei DN, Nyarko AK Tags: Genet Mol Res Source Type: research

Amoebic Liver Abscess in USAAmoebic Liver Abscess in USAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
How common are amoebic liver abscesses, and how are they contracted in the first place? Liver International (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 3, 2012 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Stem Cells Could Drive Hepatitis Research Forwardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Hepatitis C, an infectious disease that can cause inflammation and organ failure, has different effects on different people. But no one is sure why some people are very susceptible to the infection, while others are resistant. Scientists believe that if they could study liver cells from different people in the lab, they could determine how genetic differences produce these varying responses. However, liver cells are difficult to obtain and notoriously difficult to grow in a lab dish because they tend to lose their normal structure and function when removed from the body... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Detection Of Cyanide Poisoning Extended By Forensic Researchemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Researchers have found a new biomarker for cyanide poisoning, which may extend its detection window in death investigations by weeks if not months. Unless cyanide is discovered at the time of death on the mouth or nose, elevated cyanide concentrations can only be found for up to two days under current toxicological testing. A team of researchers have found a substance that appears in the liver following cyanide poisoning that could serve as a stable biomarker for a longer period of time. The research, by Dr... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 3, 2012 Category: Consumer Health News Tags: Public Health Source Type: news

Liver Function Testing with Nuclear Medicine Techniques Is Coming of Ageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews current knowledge on liver function studies and focuses on those nuclear medicine tests available to study the whole liver and regional liver function. The clinical application driving these tests, prediction of remnant liver function after partial hepatectomy for primary liver malignancy or metastatic disease, is addressed here in detail. The test was recently validated for this specific application and was shown to be better than the current standard of practice (computed tomography volumetry), particularly in patients with hepatic comorbidities like cirrhosis, steatosis, or cholestasis. Furthermore,...
Source: Seminars in Nuclear Medicine - February 3, 2012 Category: Radiology Authors: Roelof J. Bennink, Mark Tulchinsky, Wilmar de Graaf, Zakiyah Kadry, Thomas M. van Gulik Source Type: research

Am J Physiol Renal Physiol; +22 new citationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
22 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: Am J Physiol Renal Physiol These pubmed results were generated on 2012/02/02PubMed, a service of the National Library of Medicine, includes over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources. (Source: Am J Physiol Renal P...)
Source: Am J Physiol Renal P... - February 2, 2012 Category: Urology & Nephrology Tags: Report Source Type: research

Various drugs: Liver injury after concurrent use of herbal and conventional medicines: 2 case reportsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 2, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Thiocolchicoside: Liver injury: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 2, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

Multiple drug abuse: Acute kidney injury: case reportemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Reactions)
Source: Reactions - February 2, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research

FDA Says Tamsulosin Safe in Pediatric PatientsFDA Says Tamsulosin Safe in Pediatric Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The panel concurred with the FDA that tamsulosin can return to routine safety monitoring. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 2, 2012 Category: Consumer Health News Tags: Urology News Source Type: news

Risk Factors Associated with Coronary Artery Calcification Should Be Examined before Kidney Transplantation.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, the examination and prevention of risk factors associated with atherosclerosis should be started at the beginning of renal failure. PMID: 22293651 [PubMed - in process] (Source: The Tohoku Journal of Experimental Medicine)
Source: The Tohoku Journal of Experimental Medicine - February 2, 2012 Category: Research Authors: Simic-Ogrizovic S, Bogavac-Stanojevic N, Vuckovic M, Dopsaj V, Giga V, Kravljaca M, Stosovic M, Lezaic V Tags: Tohoku J Exp Med Source Type: research

UCLA researchers identify peptide that inhibits replication of hepatitis C virusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Researchers from UCLA's Jonsson Comprehensive Cancer Center have identified a cell-permeable peptide that inhibits a hepatitis C virus protein and blocks the viral replication that can lead to liver cancer and cirrhosis.   The finding by Dr. Samuel French, a UCLA assistant professor of pathology and senior author of the research, builds on previous work by French's laboratory that identified two cellular proteins that are important factors in hepatitis C virus infection.   In that earlier research, French and his team set out to identify the cellular factors involved in hepatitis C replication. Using mass spectro...
Source: UCLA Newsroom: Health Sciences - February 2, 2012 Category: Universities & Medical Training Source Type: news

Call to 'tax sugar like alcohol'email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article will be of interest to food scientists, health policy makers and the public alike, but the use of strategies to restrict the consumption of added sugar is complicated and, indeed controversial. The implications of such moves would need to be considered in both medical and societal terms. They would need both medical evidence to support their effectiveness and assurance that the public would accept drastic changes, such as age limits on buying sweets. For example, in recent years, Denmark has imposed taxes on fatty foods, a move that has divided opinions greatly. It is generally accepted that added sugar or exc...
Source: NHS News Feed - February 2, 2012 Category: Consumer Health News Tags: Food/diet Medical practice Source Type: news

Bedwetting Linked To Constipation In Childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A study by Wake Forest Baptist Medical Center reveals that the cause for bedwetting is often constipation, and not always bladder problems. If left undiagnosed, bedwetting can be an unnecessarily long, expensive and difficult challenge to cure. The study is published online in the journal Urology. The association between excess stool in the rectum (the lower 5-6 inches of the intestine) and bedwetting was first reported in 1986. The study involved 30 children aged between 5 to 15 years, old who sought treatment for bedwetting... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Medicare Pay Policy on Transplant Drugs Slammedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(MedPage Today) -- Medicare's failure to provide lifelong coverage for immunosuppressive therapy after kidney transplant is bad for patients and for the system's finances, two researchers argued. (Source: MedPage Today Geriatrics)
Source: MedPage Today Geriatrics - February 2, 2012 Category: Geriatrics Source Type: news

Post-Liver Transplantation Survival Outcomes - Cardiopulmonary Exercise Testing Helps Predictemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
According to a study in the February edition of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, preoperative cardiopulmonary exercise testing (CPET) is a specific predictor of 90-day survival after liver transplantation. The findings reveal that the CPET measurement, the anaerobic threshold or fitness level, is an important predictor of mortality in patients following transplantation... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Transplants / Organ Donations Source Type: news

Ursodeoxycholic Acid in Patients With Chronic Heart Failure: A Double-Blind, Randomized, Placebo-Controlled, Crossover Trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study sought to assess the effects of ursodeoxycholic acid (UDCA) on endothelial function and inflammatory markers in patients with chronic heart failure (CHF). Background: Endothelial dysfunction is commonly observed in patients with CHF, and it contributes to the limitation in exercise capacity that accompanies this condition. Bacterial lipopolysaccharide may trigger proinflammatory cytokine release and promote further endothelial dysfunction. UDCA, a bile acid used in the treatment of cholestatic liver disease, has anti-inflammatory and cytoprotective properties and may contribute to the formation of mixed micell...
Source: Journal of the American College of Cardiology - February 2, 2012 Category: Cardiology Authors: Stephan von Haehling, Joerg C. Schefold, Ewa A. Jankowska, Jochen Springer, Ali Vazir, Paul R. Kalra, Anja Sandek, Günter Fauler, Tatjana Stojakovic, Michael Trauner, Piotr Ponikowski, Hans-Dieter Volk, Wolfram Doehner, Andrew J.S. Coats, Philip A. Poole Tags: Heart Failure Source Type: research

High dose stereotactic body radiotherapy using three fractions for colorectal oligometastasesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ConclusionsHigh dose SBRT for colorectal oligometastases was found to produce results comparable with surgical series. To improve local control, dose higher than 48 Gy are recommend when possible, but further study will be required to define the optimal normal tissue constraints and acceptable toxicity. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - February 2, 2012 Category: Cancer & Oncology Authors: Sun Hyun BaeMi‐Sook KimChul Koo ChoJin‐Kyu KangHye Jin KangYoung Han KimUi‐Sup ShinSun Mi MoonDong Han Lee Tags: Research Article Source Type: research

Effect of hydroxyurea treatment on renal function parameters: Results from the multi‐center placebo‐controlled baby hug clinical trial for infants with sickle cell anemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ConclusionTreatment with hydroxyurea for 24 months did not influence GFR in young children with SCA. However, hydroxyurea was associated with better urine concentrating ability and less renal enlargement, suggesting some benefit to renal function. (ClinicalTrials.gov number NCT00006400) Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 2, 2012 Category: Cancer & Oncology Authors: Ofelia AlvarezScott T. MillerWinfred C. WangZhaoyu LuoM. Beth McCarvilleGeorge J. SchwartzBruce ThompsonThomas HowardRathi V. IyerSohail R. RanaZora R. RogersSharada A. SarnaikCourtney D. ThornburgRussell E. Ware Tags: Research Article Source Type: research

Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Nephron Extra 2012;2:27–38 (DOI:10.1159/000335533) (Source: Karger Publishers)
Source: Karger Publishers - February 2, 2012 Category: Cancer & Oncology Source Type: research

Ground-breaking six-organ transplant saves Alannah Shevenell, 9, from 'monster' tumouremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Alannah Shevenell, 9, is recovering at her home in Maine after a ground-breaking six-organ transplant which gave her a new esophagus, liver, stomach, spleen, pancreas and small intestine. (Source: the Mail online | Health)
Source: the Mail online | Health - February 2, 2012 Category: Consumer Health News Source Type: news

NHS launches 'vital' CKD toolkit for GPsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Toolkits to help GPs diagnose and manage chronic kidney disease (CKD) in the community have been launched by NHS Kidney Care. (Source: HealthcareRepublic Pharmacist News)
Source: HealthcareRepublic Pharmacist News - February 2, 2012 Category: Primary Care Source Type: news

Space Researchers Develop Ultrasound Technology That Detects, Treats Kidney Stonesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Just the mention of kidney stones can cause a person to cringe. They are often painful and sometimes difficult to remove, and 10 percent of the population will suffer from them. In space, the risk of developing kidney stones is exacerbated due to environmental conditions. The health risk is compounded by the fact that resource limitations and distance from Earth could restrict treatment options... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Urology / Nephrology Source Type: news

Sugar should be controlled 'like tobacco and alcohol'email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Experts warn sugary foods and drinks are responsible for illnesses including obesity, heart disease, cancer and liver problems. And they claim it contributes to 35million deaths a year worldwide. (Source: the Mail online | Health)
Source: the Mail online | Health - February 2, 2012 Category: Consumer Health News Source Type: news

Shedding Light On Nonalcoholic Fatty Liver Disease: Gene Mutation Linked To Accumulation Of Fat, Other Lipids In Liveremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A team of scientists from the University of Utah and the University of California at San Francisco has discovered that the mutation of a gene encoding a ketone body transporter triggers accumulation of fat and other lipids in the livers of zebrafish. This discovery, published in the Feb. 1, 2012, issue of Genes & Development, reveals that transport of ketone bodies out of the liver is a critical step in energy metabolism during fasting. It also provides a new approach for studying the development of fatty liver disease in humans... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Liver Disease / Hepatitis Source Type: news

Association between obesity and alteration of sperm DNA integrity and mitochondrial activityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION• Increased BMI values are associated with decreased mitochondrial activity and progressive motility and increased DNA fragmentation. (Source: BJU International)
Source: BJU International - February 2, 2012 Category: Urology & Nephrology Authors: Roberta M. FarielloJuliana R. ParizDeborah M. SpaineAgnaldo P. CedenhoRicardo P. BertollaRenato Fraietta Source Type: research

Conversion rates of abstracts presented at the Urological Society of Australia and New Zealand (USANZ) Annual Scientific Meeting into full‐text journal articlesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
What's known on the subject? and What does the study add?It is well known that the transition of a presented abstract in a scientific meeting to a journal article improves the quality of the meeting and prevents an abstract being incorporated into meta‐analyses or practice guidelines without proper appraisal.This is the first analysis of USANZ Annual Scientific Meeting abstracts’ conversion to full publication. With relatively low publication rates compared to other international meetings, this review identifies the need for mechanisms to encourage USANZ researchers to convert their abstracts into published articles.Th...
Source: BJU International - February 2, 2012 Category: Urology & Nephrology Authors: Peter D. YoonVenu ChalasaniHenry H. Woo Source Type: research

Whole genome microarray of the major pelvic ganglion after cavernous nerve injury: new insights into molecular profile changes after nerve injuryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS• The results obtained show that multiple biological processes are associated with injury and repair of the CN and provide a systematic genome‐wide screen for neurotrophic and/or inhibitory pathways of nerve regeneration.• These data identify the candidate genes that may be utilized in novel molecular‐based therapies for the preservation and protection of the CN during radical prostatectomy. (Source: BJU International)
Source: BJU International - February 2, 2012 Category: Urology & Nephrology Authors: Giulia CalendaTravis D. StrongChristian P. PavlovichEdward M. SchaefferArthur L. BurnettWayne YuKelvin P. DaviesTrinity J. Bivalacqua Source Type: research

Insulin use is not significantly predictive for prostate cancer mortality in diabetic patients: a 12‐year follow‐up studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONS• Insulin use in diabetic patients does not significantly predict the mortality from prostate cancer.• Further confirmation in other ethnicities is needed. (Source: BJU International)
Source: BJU International - February 2, 2012 Category: Urology & Nephrology Authors: Chin‐Hsiao Tseng Source Type: research

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The deoxycytidine analog decitabine (DAC) can deplete DNA methyl-transferase 1 (DNMT1) and thereby modify cellular epigenetics, gene expression, and differentiation. However, a barrier to efficacious and accessible DNMT1-targeted therapy is cytidine deaminase, an enzyme highly expressed in the intestine and liver that rapidly metabolizes DAC into inactive uridine counterparts, severely limiting exposure time and oral bioavailability. In the present study, the effects of tetrahydrouridine (THU), a competitive inhibitor of cytidine deaminase, on the pharmacokinetics and pharmacodynamics of oral DAC were evaluated in mice and...
Source: Blood - February 2, 2012 Category: Hematology Authors: Lavelle, D., Vaitkus, K., Ling, Y., Ruiz, M. A., Mahfouz, R., Ng, K. P., Negrotto, S., Smith, N., Terse, P., Engelke, K. J., Covey, J., Chan, K. K., DeSimone, J., Saunthararajah, Y. Tags: Red Cells, Iron, and Erythropoiesis Source Type: research

Durable donor engraftment after radioimmunotherapy using {alpha}-emitter astatine-211-labeled anti-CD45 antibody for conditioning in allogeneic hematopoietic cell transplantationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, conditioning with 211At-labeled anti-CD45 mAb is safe and efficacious and provides a platform for future clinical trials of nonmyeloablative transplantation with radioimmunotherapy-based conditioning. (Source: Blood)
Source: Blood - February 2, 2012 Category: Hematology Authors: Chen, Y., Kornblit, B., Hamlin, D. K., Sale, G. E., Santos, E. B., Wilbur, D. S., Storer, B. E., Storb, R., Sandmaier, B. M. Tags: Transplantation, Free Research Articles, Clinical Trials and Observations Source Type: research

Renal Replacement Therapy in Cardiology Wards: Changing Trends in a Transitional Countryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractThe leading causes of death in patients with chronic kidney disease (CKD) are cardiovascular diseases, regardless of the stage of disease or method of renal replacement therapy. On the other hand, CKD is a major risk factor for cardiovascular complications after acute myocardial infarction, as well as for adverse outcome in patients with chronic heart failure. In the present study we prospectively followed‐up nephrological interventions in cardiology wards in order to determine changes in indications, treatment possibilities and outcome of patients. All patients treated at cardiology ward of the Clinical Hospital...
Source: Therapeutic Apheresis and Dialysis - February 2, 2012 Category: Hematology Authors: Iva Bacak‐KocmanNikolina Basic‐JukicVesna LovcicIngrid PrkacinDavor MilicicPetar Kes Source Type: research

Direct to consumer Internet advertising of statins: an assessment of safetyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ConclusionsA potential purchaser of statins is likely to encounter websites from a wide geographical base and of generally poor quality. This has potentially serious implications for the safety of purchasers who may not be aware of the problems associated with ordering medicines online or the actual medication, which they receive. Direct to consumer advertising websites need tighter controls. Copyright © 2012 John Wiley & Sons, Ltd. (Source: Pharmacoepidemiology and Drug Safety)
Source: Pharmacoepidemiology and Drug Safety - February 2, 2012 Category: Drugs & Pharmacology Authors: Bethan WilliamsDavid Brown Tags: Original Report Source Type: research

Does Terfenadine‐Induced Ventricular Tachycardia/Fibrillation Directly Relate to Its QT Prolongation and Torsades de Pointes?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion:  Our data suggest 1). the induction of non‐TdP‐like VT/VF, which is caused by slowing of conduction via blockade of INa (like Class Ic flecainide), may constitute a more important risk for terfenadine‐induced cardiac death, 2). although terfenadine is a potent hERG blocker, the risk for non‐TdP‐like VT/VF exceeds the risk for TdPs, 3). the role of cardiac wavelength could serve as a biomarker for terfenadine‐induced VT/VF.© Janssen Pharmaceutica NV British Journal of Pharmacology © The British Pharmacological Society (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - February 2, 2012 Category: Drugs & Pharmacology Authors: Hua Rong LuAn N. HermansDavid J Gallacher Source Type: research

The omega‐3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse mc‐26 colorectal cancer cell liver metastasis via inhibition of prostaglandin e2‐dependent cell motilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions:  EPA‐FFA inhibits MC‐26 CRC cell liver metastasis. EPA incorporation is associated with a ‘PGE2 to PGE3 switch’ in liver tumours. Inhibition of PGE2‐EP4 receptor‐dependent CRC cell motility likely contributes to the anti‐neoplastic activity of EPA.© 2012 The Authors. British Journal of Pharmacology © 2012 The British Pharmacological Society (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - February 2, 2012 Category: Drugs & Pharmacology Authors: G HawcroftM VolpatoG MarstonN IngramS L PerryA J CockbainA D RaceA MunariniA BelluzziP M LoadmanP L ColettaM A Hull Source Type: research

Rituximab possible treatment option for patients with primary biliary cirrhosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Wiley-Blackwell) An open-label study of rituximab, a monoclonal antibody for human CD20, was shown to be safe in patients with primary biliary cirrhosis who had an incomplete response to the standard ursodeoxycholic acid therapy. Study details available in the February issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, report that rituximab was successful in reducing the level of alkaline phosphatase -- a protein used to measure liver injury. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 2, 2012 Category: Global & Universal Source Type: news

A new screening method for prostate canceremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(NYU Langone Medical Center / New York University School of Medicine) A new study by NYU Langone Medical Center and Northwestern University Feinberg School of Medicine shows novel PSA velocity risk count testing may provide a more effective way for physicians to screen men for clinically significant prostate cancer. The new study, published online by the British Journal of Urology International, shows the benefits of tracking a man's PSA levels over time to help doctors more accurately assess his risk of life-threatening prostate cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 2, 2012 Category: Global & Universal Source Type: news

Coffee consumption reduces fibrosis risk in those with fatty liver diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Wiley-Blackwell) Caffeine consumption has long been associated with decreased risk of liver disease and reduced fibrosis in patients with chronic liver disease. Now, newly published research confirms that coffee caffeine consumption reduces the risk of advanced fibrosis in those with nonalcoholic fatty liver disease. Findings published in the February issue of Hepatology, a journal of the American Association for the Study of Liver Diseases, show that increased coffee intake, specifically among patients with nonalcoholic steatohepatitis, decreases risk of hepatic fibrosis. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 2, 2012 Category: Global & Universal Source Type: news

Phase II Study of AS1411 in RCCemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The aim of this study is to evaluate the efficacy of AS1411 in patients with Metastatic Renal Cell Carcinoma.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Vaccine Therapy With or Without Fludarabineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This randomized phase II trial is studying vaccine therapy and fludarabine to see how well they work compared to vaccine therapy alone in treating patients with stage IV kidney cancer.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Bevacizumab and Sunitinib in Treating Patients With Solid Tumorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Sunitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab and sunitinib may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving bevacizumab together with sunitinib may kill more tumor cells.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Thermal ablation of renal cell carcinomaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The incidence of renal cell carcinoma (RCC) is increasing. With the increasing emphasis on minimally invasive nephron-sparing surgery, thermal ablation is playing a larger role in the management of patients with this disease.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Familial renal cancer as an indicatoremail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) is a hereditary condition which typically presents with cutaneous and uterine leiomyomata. Papillary type II renal cell carcinoma and other less common histologic subtypes of renal cancer have been reported in HLRCC.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Small Renal Oncocytomasemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
To evaluate characteristic imaging findings of tumor attenuation in multiphase computed tomography (CT) between renal oncocytomas and clear-cell renal cell carcinoma (ccRCC) of small tumor size ( (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

Quality of life during dendritic cell vaccinationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The data indicate that dendritic cells (DCs) vaccination, which is a personalised treatment modality, maintains quality of life (QoL) and thus represents an attractive nontoxic treatment option for patients with metastatic renal cell carcinoma (RCC).02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

2012 GU ASCO "Daily News"email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Kidney Cancer Association is podcasting live from the 2012 Genitourinary Cancers Symposium, in San Francisco. For the latest information from this event,be sure to read the "Daily News" online.02/01/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 1, 2012 Category: Cancer & Oncology Source Type: news

What Is Killing People With Hepatitis C Virus Infection?What Is Killing People With Hepatitis C Virus Infection?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
What is it about hepatitis C that makes it such a potentially deadly disease? This new study takes a close look at the disease. Seminars in Liver Disease (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 1, 2012 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news