Veterinary Research Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 33.

EVECCS News
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Tags: EVECCT News Source Type: research

VECCS News
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Tags: EVECCT News Source Type: research

ACVECC/AVECCT News
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Tags: EVECCT News Source Type: research

UPCOMING VECCS CE PROGRAMS
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Tags: EVECCT News Source Type: research

Early nutritional support is associated with decreased length of hospitalization in dogs with septic peritonitis: A retrospective study of 45 cases (2000–2009)
ConclusionEarly nutritional support in dogs with septic peritonitis is associated with a shorter hospitalization length.
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Authors: Debra T. Liu, Dorothy C. Brown, Deborah C. Silverstein Tags: Retrospective Study Source Type: research

A review of the pharmacology and clinical uses of pimobendan.
ConclusionsThe use of pimobendan, an inodilator with phosphodiesterase 3 (PDE3) inhibitory and calcium‐sensitizing properties, is regarded as a component of the standard of care in the management of dogs with CHF secondary to both DCM and CVHD. Further studies are warranted to confirm the safety and efficacy of pimobendan for the off‐label use of this drug in asymptomatic CVHD, pulmonary arterial hypertension, asymptomatic myocardial diseases, CHF from all other causes and in cats with CHF.
Source: Journal of Veterinary Emergency and Critical Care - August 28, 2012 Category: Veterinary Research Authors: Kimberly L. Boyle, Elizabeth Leech Tags: State of the Art Review Source Type: research

Small animal soft tissue surgery edited by DA Yool . CABI Publishing, Oxfordshire, 2012. 394 pages. Price US$99.95. ISBN 978 1 84593 821 5.
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: John Culvenor Tags: BOOK REVIEW Source Type: research

Kirk and Bistner's handbook of veterinary procedures and emergency treatment. 9th edn. Edited by RB Ford , EM Mazzaferro . Elsevier Saunders, St Louis, 2012. 767 pages. Price A$97.00. ISBN 978 1 43770 798 4.
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: Angela See Tags: BOOK REVIEW Source Type: research

Equine pediatric medicine edited by W Bernard , BS Barr . Manson Publishing, London, 2012. 352 pages. Price £99.50. ISBN 978 1 84076 081 1.
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: Laura Nath Tags: BOOK REVIEW Source Type: research

Small animal clinical diagnosis by laboratory methods. 5th edn. Edited by MD Willard and H Tvedten . Elsevier, St Louis, 2012. 418 pages. Price A$92. ISBN 978 1 43770 657 4.
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: PH Brain Tags: BOOK REVIEW Source Type: research

Veterinary science in the tropics edited by RSF Campbell . James Cook University, Townsville, 2010. 122 pages. Price $25. ISBN 978 0 98081 830 7.
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: M McLennan Tags: BOOK REVIEW Source Type: research

John (Jack) Henry Irvine
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: Joe Boray, Mike Irvine Tags: OBITUARY Source Type: research

In this issue – September 2012
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Authors: N Metzl, A Jackson Tags: SCIENTIFIC AND CLINICAL Source Type: research

NEWS
Source: Australian Veterinary Journal - August 28, 2012 Category: Veterinary Research Tags: NEWS Source Type: research

Obesity-related metabolic dysfunction in dogs: a comparison with human metabolic syndrome
Conclusions: In this study, approximately 20% of obese dogs suffer from ORMD, and this is characterized by hypoadiponectinaemia and hyperinsulinaemia. These studies can form the basis of further investigations to determine path genetic mechanisms and the health significance for dogs, in terms of disease associations and outcomes of weight loss.
Source: BMC Veterinary Research - Latest articles - August 28, 2012 Category: Veterinary Research Authors: Asta TvarijonaviciuteJose CeronShelley HoldenDaniel CuthbertsonVincent BiourgePenelope MorrisAlexander German Source Type: research

Histopathological classification and immunophenotyping of spontaneous canine lymphoma in Bangkok metropolitan
Abstract The purpose of this study was to examine the immunophenotype of canine lymphomas according to the updated Kiel classification adapted for canine species and to relate the immunophenotype to the anatomical classification, clinical stage, and the malignancy. Forty formalin-fixed embedded tissue sections from dogs affected with lymphoma during 2002–2008 at the Department of Veterinary Pathology, Faculty of Veterinary Science, Chulalongkorn University were retrospectively studied. Results indicated that the prevalence of canine lymphoma occurred at the average age of 7.6 years old. Of the total 4...
Source: Comparative Clinical Pathology - August 27, 2012 Category: Pathology Tags: Comparative Clinical Pathology Source Type: research

Lipoid pneumonia associated with diabetes mellitus type II in a cat
Abstract Our purpose is to report a rare case of lipoid pneumonia found in a cat with diabetes mellitus (DM) type II. The cat is an aged, mixed-breed male with a 3-year history of having DM. During the last 16 weeks of its life, the cat presented signs of dyspnea and weakness and was continuously treated by nebulization. Thoracic radiography showed an increased radiopacity of the alveoli. The histopathological findings showed typical lipoid pneumonia, proliferative bronchitis, and diffuse suppurative pneumonia. Chronic pancreatitis with islet amyloidosis and arteriosclerosis was also detected. Immunohis...
Source: Comparative Clinical Pathology - August 27, 2012 Category: Pathology Tags: Comparative Clinical Pathology Source Type: research

Evaluation of serum total protein concentration and protein fractions in sheep naturally infected with Babesia ovis
Abstract Serum electrophoresis in cellulose acetate strip is a technique commonly used to separate the protein fractions. This technique allows detecting quantitative and qualitative changes in the serum proteins associated with different diseases. The aim of this study was to characterize the changes of the serum protein fractions produced in sheep suffering from babesiosis. Blood samples were collected from 52 healthy and naturally infected sheep with Babesia ovis. Serum total proteins were calculated, and serum electrophoresis was performed. The parasitological diagnosis was confirmed using polymerase cha...
Source: Comparative Clinical Pathology - August 27, 2012 Category: Pathology Tags: Comparative Clinical Pathology Source Type: research

Obituary: Professor John Daniel Collins MVB MVM MS (Calif.) PhD MRCVS
Professor John Daniel Collins (born 1938), Professor Emeritus of Farm Animal Clinical Studies at University College Dublin (UCD), and prominent in research into bovine tuberculosis, passed away on April 25, 2012. Dan, a native of Waterford city, made immense contributions to our understanding of tuberculosis in cattle and wildlife, not just in Ireland but also in many countries worldwide. He was instrumental in setting up, and became the first Director of the Tuberculosis Investigation Unit (now the Centre for Veterinary Epidemiology and Risk Analysis, CVERA) based in the Veterinary College in UCD, with a mandate to provid...
Source: Tuberculosis - August 27, 2012 Category: Respiratory Medicine Authors: Eamonn Gormley Tags: Obituary Source Type: research

Investigation of equine influenza virus in two geographical regions of Pakistan
Conclusions Influenza viruses are circulating in equine species and continuous surveillance is needed to keep check on any future outbreak. Content Type Journal ArticleCategory Short CommunicationsPages 1-2DOI 10.1007/s11250-012-0247-5Authors Muhammad Sajid, Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, PakistanMansur-ud-Din Ahmad, Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, Lahore, PakistanMuhammad Athar Khan, Department of Epidemiology and Public Health, University of Veterinary and Animal Sciences, L...
Source: Tropical Animal Health and Production - August 27, 2012 Category: Veterinary Research Tags: Tropical Animal Health and Production Source Type: research

A live weight–heart girth relationship for accurate dosing of east African shorthorn zebu cattle
Abstract The accurate estimation of livestock weights is important for many aspects of livestock management including nutrition, production and appropriate dosing of pharmaceuticals. Subtherapeutic dosing has been shown to accelerate pathogen resistance which can have subsequent widespread impacts. There are a number of published models for the prediction of live weight from morphometric measurements of cattle, but many of these models use measurements difficult to gather and include complicated age, size and gender stratification. In this paper, we use data from the Infectious Diseases of East Africa calf c...
Source: Tropical Animal Health and Production - August 27, 2012 Category: Veterinary Research Tags: Tropical Animal Health and Production Source Type: research

Phlebotomine sandflies and the spreading of leishmaniases and other diseases of public health concern
Phlebotomine sandflies transmit pathogens that affect humans and animals worldwide. We review the roles of phlebotomines in the spreading of leishmaniases, sandfly fever, summer meningitis, vesicular stomatitis, Chandipura virus encephalitis and Carrión's disease. Among over 800 species of sandfly recorded, 98 are proven or suspected vectors of human leishmaniases; these include 42 Phlebotomus species in the Old World and 56 Lutzomyia species in the New World (all: Diptera: Psychodidae). Based on incrimination criteria, we provide an updated list of proven or suspected vector species by endemic country where data are avai...
Source: Medical and Veterinary Entomology - August 27, 2012 Category: Veterinary Research Authors: M. MAROLI, M. D. FELICIANGELI, L. BICHAUD, R. N. CHARREL, L. GRADONI Source Type: research

Inhibition of protein synthesis on the ribosome comparing tildipirosin with other veterinary macrolides.
Abstract Tildipirosin is a 16-membered ring macrolide developed to treat bacterial pathogens including Mannheimia haemolytica and Pasteurella multocida that cause respiratory tract infections in cattle and swine. Here we evaluate the efficacy of tildipirosin at inhibiting protein synthesis on the ribosome (IC(50) 0.23±0.01 μM) and compare with the established veterinary macrolides tylosin, tilmicosin and tulathromycin. Mutation and methylation at key rRNA nucleotides reveal differences in the interactions of these macrolides within their common ribosomal binding site. PMID: 22926570 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - August 27, 2012 Category: Microbiology Authors: Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S Tags: Antimicrob Agents Chemother Source Type: research

Fibrinolytic Activity in Cerebrospinal Fluid of Dogs with Different Neurological Disorders
Conclusions and Clinical ImportanceIntrathecal fibrinolytic activity seems to be activated in some canine neurological disorders, and it is high in severe meningeal inflammatory diseases. CSF D‐dimer concentrations may be considered a diagnostic marker for SRMA.
Source: Journal of Veterinary Internal Medicine - August 27, 2012 Category: Veterinary Research Authors: C. la Fuente, L. Monreal, J. Cerón, J. Pastor, J. Viu, S. Añor Tags: Original Article Source Type: research

Effects of N‐Butylscopolammonium Bromide on Lung Function in Horses with Recurrent Airway Obstruction
Conclusion and Clinical ImportanceN‐butylscopolammonium bromide is a potent bronchodilator, reaching maximum effect 10 minutes after intravenous administration. This effect dissipates within 1 hour of drug administration.
Source: Journal of Veterinary Internal Medicine - August 27, 2012 Category: Veterinary Research Authors: L. Couetil, J. Hammer, M. Miskovic Feutz, N. Nogradi, C. Perez‐Moreno, K. Ivester Tags: Original Article Source Type: research

Markers of Systemic Inflammation in Horses with Heaves
Conclusions and Clinical ImportanceIn heaves, haptoglobin is a marker of both acute and chronic systemic inflammation, whereas high concentrations of SAA indicate acute inflammation.
Source: Journal of Veterinary Internal Medicine - August 27, 2012 Category: Veterinary Research Authors: A. Lavoie‐Lamoureux, M. Leclere, K. Lemos, B. Wagner, J.‐P. Lavoie Tags: Original Article Source Type: research

Leptospira spp. strain identification by MALDI TOF MS is an equivalent tool to 16S rRNA gene sequencing and multi locus sequence typing (MLST)
Conclusions: MALDI-TOF MS analysis is a fast and reliable method for species identification, although Leptospira organisms need to be produced in a time-consuming culture process. All leptospiral strains were identified, at least at the species level, using our described extraction protocol. Statistical analysis of the three genomospecies L. borgpetersenii, L. interrogans and L. kirschneri revealed distinctive, reproducible differentiating peaks for seven leptospiral strains which represent seven serovars. Results obtained by MALDI-TOF MS were confirmed by MLST and 16S rRNA gene sequencing.
Source: BMC Microbiology - Latest articles - August 27, 2012 Category: Microbiology Authors: Anna RettingerInke KrupkaKarola GrünwaldViktor DyachenkoVolker FingerleRegina KonradHeribert RaschelUlrich BuschAndreas SingReinhard StraubingerIngrid Huber Source Type: research

Prevalence of Classical Swine Fever Virus in Domestic Pigs in South Korea: 1999–2011
Summary The major policy for eradication of classical swine fever (CSF) in South Korea has focused on the implementation of compulsory vaccination of the susceptible pig population. A vaccine strain of CSF virus, the LOM strain, is used to maintain high herd seroconversion, a practice complementary to the ‘stamping‐out policy’ and restriction of animal movement during disease outbreaks. To survey for the prevalence of CSF in domestic pigs in South Korea over the past 13 years (1999–2011), we tested 4 193 782 and 1 162 645 samples for antibodies and antigens, respectively. Whereas seropositivity for CSF antibod...
Source: Transboundary and Emerging Diseases - August 27, 2012 Category: Veterinary Research Authors: J. ‐Y. Song, S. I. Lim, H. Y. Jeoung, E. ‐J. Choi, B. ‐H. Hyun, B. Kim, J. Kim, Y. ‐K. Shin, R. C. dela Pena, J. B. Kim, H. Joo, D. J. An Tags: Short Communication Source Type: research

Canine mesenchymal stem cells are effectively labeled with silica nanoparticles and unambiguously visualized in highly autofluorescent tissues
Conclusions: The results of the current study showed that silica nanoparticles are useful as an effective labeling marker for MSCs, which can elucidate the distribution and fate of transplanted MSCs.
Source: BMC Veterinary Research - Latest articles - August 27, 2012 Category: Veterinary Research Authors: Sei-Myoung HanHee-Woo LeeDong-Ha BhangKyoung-Won SeoHwa-Young Youn Source Type: research

Unexpected genetic diversity of Mycoplasma agalactiae caprine isolates from an endemic geographically restricted area of Spain
Conclusions: The important genetic diversity of MA observed in infected goats from Spain contrasts with the overall homogeneity of the genomic background encountered in MA from sheep with CA in Southern France or Italy, suggesting that assessment of the disease status in endemic areas may require different approaches in sheep and in goats. A number of congruent sub-typing tools are now available for the differentiation of caprine isolates with comparable discriminatory powers.
Source: BMC Veterinary Research - Latest articles - August 27, 2012 Category: Veterinary Research Authors: Christian De la FeJoaquín AmoresFlorence TardyEvelyne SagneLaurent NouvelChristine Citti Source Type: research

Detection of tick‐borne pathogens in ticks from migratory birds in the Baltic region of Russia
We report the finding of tick‐borne encephalitis (TBE)‐virus in indigenous Ixodes ricinus (L.), ‘Candidatus Neoehrlichia mikurensis’ in exotic Ixodes frontalis (Panzer) and Rickettsia aeshlimannii in exotic Hyalomma marginatum Koch subadult ticks detached from 18.5% (107/577) infested migratory birds in the Baltic region of Russia. This is the first record of human pathogenic ‘Candidatus N. mikurensis’ in I. frontalis ticks. Moreover, seven other pathogens were identified in I. ricinus ticks. Spotted Fever Group rickettsiae were the predominant pathogen group and were detected only in nymphs. Future investigati...
Source: Medical and Veterinary Entomology - August 27, 2012 Category: Veterinary Research Authors: A. MOVILA, A. N. ALEKSEEV, H. V. DUBININA, I. TODERAS Source Type: research

Gene expression profiling demonstrates differential expression of osteopontin in follicular thyroid carcinomas compared to normal thyroid tissue in dogs
Abstract Follicular thyroid carcinoma (FTC) is an aggressive tumour in dogs with little known about its molecular pathogenesis. The overall goal of this study was to examine FTC and normal thyroid tissue gene expression. Microarray analysis was performed on a pilot group of five FTC‐affected dogs and four healthy dogs, and then osteopontin validated with quantitative polymerase chain reaction (PCR) and immunohistochemistry (IHC) of thyroid tissue from non‐invasive FTC, invasive FTC and healthy dogs. On microarray analysis, 489 transcripts were differentially expressed between FTC and normal thyroid: 242 transcripts wer...
Source: Veterinary and Comparative Oncology - August 26, 2012 Category: Veterinary Research Authors: K. S. Metivier, K. Deitz, W. W. Xu, M. Conzemius, V. L. Wilke Tags: Original Article Source Type: research

Cerebral hypoxia in a cat following pharyngoscopy involving use of a mouth gag
Source: Veterinary Anaesthesia and Analgesia - August 25, 2012 Category: Veterinary Research Authors: Cristina de Miguel Garcia, Martin Whiting, Hatim Alibhai Tags: LETTER TO THE EDITOR Source Type: research

A large seroprevalence survey of brucellosis in cattle herds under diverse production systems in northern Nigeria
Conclusion: This is the first large study to assess the prevalence of bovine brucellosis over a wide geographic area of northern Nigeria, in a variety of management systems and using accurate tests. The seroprevalence of brucellosis was high, and higher than results of previous studies in northern Nigeria. The pastoral management systems of the traditional Fulanis may be encouraging the dissemination of the disease. Public enlightenment of the farmers about the disease, vaccination and appropriate national control measures are recommended.
Source: BMC Veterinary Research - Latest articles - August 25, 2012 Category: Veterinary Research Authors: Hassan MaiPeter IronsPeter Thompson Source Type: research

Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells
Conclusions: Taken together, E2-induced up-regulation of SBD-1 expressions were GPR30-dependent during prophase and ERs-dependent during later-stage in ovine oviduct epithelial cells, and we assume that the effect was completed by the PKA, PKC, and NF-kappaB pathways simultaneous.
Source: BMC Veterinary Research - Latest articles - August 25, 2012 Category: Veterinary Research Authors: Shiyong WenGuifang CaoTuya BaoLanling ChengHaijun LiChenguan DuYong TuQi LiRuizhen JianPengwei ZhaoWu riliga Source Type: research

Differential expression of TAR DNA-binding protein (TDP-43) in the central nervous system of horses afflicted with equine motor neuron disease (EMND): a preliminary study of a potential pathologic marker
We examined whether horses afflicted with EMND express the TDP-43 in CNS. Ten horses with EMND and 6 controls of different ages and breed we enrolled. Detection of presence of TDP-43 protein in the CNS was analyzed by immunohistochemical staining using rabbit anti-human TARDBP (TDP-43) polyclonal antibody. Formalin fixed neuronal tissues from medulla, cervical, and lumbar spinal cord were harvested from EMND and from control horses. Sections were assigned randomly to TDP-43 treated or rabbit anti-IgG as control. Nuclear staining of TDP-43 was detected in one of the neural tissues of 75 % of EMND-positive and 0 of...
Source: Veterinary Research Communications - August 23, 2012 Category: Veterinary Research Tags: Veterinary Research Communications Source Type: research

Full genomic sequence of an African Avian Paramyxovirus Type 4 strain isolated from a wild duck
Abstract A random amplification/deep sequencing approach was applied to determine the complete genomic sequence of an Avian Paramyxovirus Type 4 (APMV-4) strain isolated from a wild duck in South Africa in 2010. This sequence represents the fourth full genome of APMV-4 in public sequence databases and the first for the African continent. A total of 87,402,081 Illumina paired-end reads were obtained of which 47,338,867 (54.16 %) mapped to the reference genome EU877976. The entire genomic sequence of 15,054 nt, including the intact termini, was recovered at a high redundancy (coverage per base: average&nb...
Source: Virus Genes - August 23, 2012 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: research

Chemical coding of zinc-enriched neurons in the intramural ganglia of the porcine jejunum
Abstract Zinc ions in the synaptic vesicles of zinc-enriched neurons (ZEN) seem to have an important role in normal physiological and pathophysiological processes in target organ innervation. The factor directly responsible for the transport of zinc ions into synaptic vesicles is zinc transporter 3 (ZnT3), a member of the divalent cation zinc transporters and an excellent marker of ZEN neurons. As data concerning the existence of ZEN neurons in the small intestine is lacking, this study was designed to disclose the presence and neurochemical coding of such neurons in the porcine jejunum. Cryostat sections (1...
Source: Cell and Tissue Research - August 23, 2012 Category: Cytology Tags: Cell and Tissue Research Source Type: research

Editorial Board/Table of Contents
Source: Journal of Veterinary Behavior: Clinical Applications and Research - August 23, 2012 Category: Veterinary Research Tags: Frontmatter Source Type: research

Regional distribution of technetium-99m-ECD in the canine brain: Optimal injection–acquisition interval in adult beagles
This study shows that in dogs, regional differences in the clearance of 99mTc-ECD result in significant alterations of the perfusion indices from 65 minutes onward after tracer injection. Therefore, it is recommended to start the acquisition between 15 and 40 minutes postinjection in dogs when this technique is used for studying rCBF alterations in dogs with behavioral problems.
Source: Journal of Veterinary Behavior: Clinical Applications and Research - August 23, 2012 Category: Veterinary Research Authors: Tim Waelbers, Kathelijne Peremans, Simon Vermeire, Koen Piron, Ingeborgh Polis Tags: Research Source Type: research

Novel approaches to measuring and changing behavior
The Journal of Veterinary Behavior: Clinical Applications and Research is making some changes that should benefit our readership. The journal has become wildly popular attracting an impressive and diverse array of high quality papers. Because we have a backlog of papers to publish, we have begun to put in press articles online as an advance publication. We will continue to publish select research abstracts, but they will move to an online format, only. Finally, this issue features the first article that we have fast-tracked for publication.
Source: Journal of Veterinary Behavior: Clinical Applications and Research - August 23, 2012 Category: Veterinary Research Authors: Karen L. Overall Tags: Editorial Source Type: research

Dermatophytes from skin lesions of domestic animals in Nsukka, Enugu State, Nigeria.
Conclusions and clinical importance - Anthropophilic dermatophytes are among the fungal agents associated with dermatophytosis in animals in Nsukka Agricultural Zone. These dermatophytes could constitute health risks to humans in contact with the animals. PMID: 22913664 [PubMed - as supplied by publisher]
Source: Veterinary Dermatology - August 23, 2012 Category: Veterinary Research Authors: Chah KF, Majiagbe KA, Kazeem HM, Ezeanyika O, Agbo IC Tags: Vet Dermatol Source Type: research

Author Index
Source: Journal of Veterinary Emergency and Critical Care - August 23, 2012 Category: Veterinary Research Tags: Author Index Source Type: research

Abstracts from the International Veterinary Emergency and Critical Care Symposium and the European Veterinary Emergency and Critical Care Society Annual Congress, 2012
Source: Journal of Veterinary Emergency and Critical Care - August 23, 2012 Category: Veterinary Research Tags: Abstracts from the IVECCS and EVECCS Annual Congress, 2012 Source Type: research

The isolated perfused equine distal limb as an ex vivo model for pharmacokinetic studies
Even though intra‐articular injections play an important role in the treatment of joint‐related lameness in horses, little is known about pharmacokinetic properties of substances used. Therefore, an ex vivo model for pharmacokinetic studies was developed using distal forelimbs of slaughtered horses. The extremity was perfused with gassed Tyrode solution for up to 8 h. Tissue viability was confirmed by measurements of glucose consumption, lactate production, and lactate dehydrogenase activity in the perfusate. Standard criteria for tissue viability had been determined in preliminary experiments (n = 11), which also i...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 23, 2012 Category: Veterinary Research Authors: M. Friebe, J. Stahl, M. Kietzmann Tags: Scientific Paper Source Type: research

Influence of oxytetracycline on carprofen pharmacodynamics and pharmacokinetics in calves
A tissue cage model of inflammation in calves was used to determine the pharmacokinetic and pharmacodynamic properties of individual carprofen enantiomers, following the administration of the racemate. RS(±) carprofen was administered subcutaneously both alone and in combination with intramuscularly administered oxytetracycline in a four‐period crossover study. Oxytetracycline did not influence the pharmacokinetics of R(−) and S(+) carprofen enantiomers, except for a lower maximum concentration (Cmax) of S(+) carprofen in serum after co‐administration with oxytetracycline. S(+) enantiomer means for area under the se...
Source: Journal of Veterinary Pharmacology and Therapeutics - August 23, 2012 Category: Veterinary Research Authors: C. Brentnall, Z. Cheng, Q. A. Mckellar, P. Lees Tags: Scientific Paper Source Type: research

Pyogranulomatous lesion causing neurological signs localised to the sacral region in a horse
This case report describes neurological signs associated with a pyogranulomatous lesion within the sacral vertebral canal of a horse. The clinical findings included urinary overflow incontinence and reduced anal, perianal and tail tone. The horse failed to respond to medical management and a guarded prognosis for return to athletic performance initiated the decision for euthanasia.
Source: Australian Veterinary Journal - August 23, 2012 Category: Veterinary Research Authors: LA Cudmore, JC Groenendyk, P Hodge, S Church Tags: Equine Source Type: research

Feasibility of infrared spectroscopy with pattern recognition techniques to identify a subpopulation of mares at risk of producing foals diagnosed with failure of transfer of passive immunity
ConclusionThis preliminary study demonstrates that infrared spectra of dam serum have the potential to provide the basis for a new periparturient screening method for a subpopulation of mares at risk of having a foal susceptible to FPT. Further development may provide an economic and rapid technique for the pre‐parturient assessment of mares.
Source: Australian Veterinary Journal - August 23, 2012 Category: Veterinary Research Authors: CB Riley, JT McClure, S Low‐Ying, BK Dolenko, RL Somorjai, RA Shaw Tags: Equine Source Type: research

Behavioural responses of lambs to plastic clips as an alternative procedure to mulesing
ConclusionThese behavioural results, together with previous behavioural and physiological research, indicate that the effect on lamb welfare of applying occlusive clips is less than that of surgical mulesing.
Source: Australian Veterinary Journal - August 23, 2012 Category: Veterinary Research Authors: PH Hemsworth, GM Cronin, JL Barnett, KL Butler, EC Jongman, GA Karlen, A Coffey, NA Arnold Tags: Production Animals Source Type: research