Virology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
17352 records returned
Key Peptides Identified That Could Lead To A Universal Vaccine For Influenza
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Researchers at the University of Southampton, University of Oxford and Retroscreeen Virology Ltd have discovered a series of peptides, found on the internal structures of influenza viruses that could lead to the development of a universal vaccine for influenza, one that gives people immunity against all strains of the disease, including seasonal, avian, and swine flu. Influenza, an acute viral infection, affects hundreds of thousands of people a year and puts an enormous strain on healthcare providers globally... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news
A transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against porcine reproductive and respiratory syndrome virusEmail this article to a colleague.
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In this study, we designed 5 of the small hairpin RNAs (shRNAs) targeting the GP5 and M gene of PRRSV
respectively, and investigated their inhibition to the production of PRRSV. The highest activity displayed in shRNAs of the
ORF6e sequence (nts 261-279), which the inhibition rate reached was 99.09%. The result suggests that RNAi technology might
serve as a potential molecular strategy for PRRSV therapy. Furthermore, the transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against PRRS virus was established. It presented stable inhibition to
the replication and amplification of PRRS...
Source: Veterinary Research Communications - February 1, 2012 Category: Veterinary Research Tags: Veterinary Research Communications Source Type: research
Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell linesEmail this article to a colleague.
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This study suggests different antiviral
functions of polyvalent IVIG and confirms their potential to inhibit a CMV infection in vitro, with profound differences between
the hereby used IVIG products.
Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00430-012-0229-2Authors
K. Frenzel, Institute of Medical Virology, Helmut-Ruska-Haus, Charité University Medicine, Charitéplatz 1, 10117 Berlin, GermanyS. Ganepola, Department of Haematology, Oncology and Transfusion Medicine, Charité University Medicine, Berlin, GermanyD. Michel, Institute of Virology, University Hospital Ulm, Ulm, GermanyE....
Source: Medical Microbiology and Immunology - February 1, 2012 Category: Microbiology Tags: Medical Microbiology and Immunology Source Type: research
Influenza vaccination of healthcare workers in acute-care hospitals: a case-control study of its effect on hospital-acquired influenza among patientsEmail this article to a colleague.
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Conclusions:
Our observational study indicates a shielding effect of more than 35% of vaccinated HCW on HAI among patients in acute-care units. Investigations, such as controlled clinical trials, are needed to validate the benefits of HCW vaccination on HAI incidence in patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 1, 2012 Category: Infectious Diseases Authors: Thomas BenetCorinne RegisNicolas VoirinOlivier RobertBruno LinaSilene CronenbergerBrigitte ComteBrigitte CopperePhilippe Vanhems Source Type: research
UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patientsEmail this article to a colleague.
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ConclusionsThese UK Consensus guidelines indicate the current best practice for the use of boceprevir and telaprevir in the management of genotype 1 chronic HCV infection. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 1, 2012 Category: Drugs & Pharmacology Authors: P. RamachandranA. FraserK. AgarwalA. AustinA. BrownG. R. FosterR. FoxP. C. HayesC. LeenP. R. MillsD. J. MutimerS. D. RyderJ. F. Dillon Tags: Original Article Source Type: research
A DNA vaccine expressing PB1 protein of influenza A virus protects mice against virus infectionEmail this article to a colleague.
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Abstract Although influenza DNA vaccine research has focused mainly on viral hemagglutinin and has led to promising results, other
virion proteins have also shown some protective potential. In this work, we explored the potential of a DNA vaccine based
on the PB1 protein to protect BALB/c mice against lethal influenza A virus infection. The DNA vaccine consisted of pTriEx4
plasmid expressing PB1. As a positive control, a pTriEx4 plasmid expressing influenza A virus HA was used. Two weeks after
three subcutaneous doses of DNA vaccine, the mice were challenged intranasally with 1 LD50 of A/Puerto Rico/8/34 (H1...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Superiority of the buffy coat over serum or plasma for the detection of Alkhumra virus RNA using real time RT-PCREmail this article to a colleague.
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In this study, RT-PCR detection of viral RNA from the plasma, serum, and buffy coat (BC)
was compared to virus isolation. Plasma, serum, and BC were obtained from seven patients with clinically suspected ALKV infection
in Najran, Saudi Arabia. Baby hamster kidney (BHK-21) and rhesus monkey kidney (LLC-MK2) cell culture monolayers were used
for virus isolation. Real-time RT-PCR was used to confirm ALKV infection and to detect viral RNA directly from plasma, serum,
and BC. ALKV was isolated from five of the seven patients. The virus was isolated from all three specimen types (plasma, serum,
and BC) of the five confirmed...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in GreeceEmail this article to a colleague.
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Abstract The E2 gene of human papilloma virus is expressed at the early stage of the viral life cycle, encoding the E2 transcription
factor, and regulates the expression of E6 and E7 oncogenes. Disruption of E2 gene due to viral integration inhibits the transcriptional
suppression of the HPV oncogenes, inducing cell proliferation. In the present study, a total of 22 HPV16-positive cytological
specimens derived from high- and low-grade cervical intraepithelial lesions were investigated in order to identify sequence
variations in the HPV16 E2 ORF. The E2 gene was amplified by PCR using external and internal ov...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
QnAs with Harald zur Hausen [QnAs]Email this article to a colleague.
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The first carcinogenic virus was discovered in chickens in 1911. More than 70 years later, Harald zur Hausen demonstrated that human papillomavirus (HPV) can cause cervical cancer, for which he garnered the 2008 Nobel Prize in Medicine or Physiology. A professor emeritus at the German Cancer Research Center and recently elected member of the National Academy of Sciences, zur Hausen’s contributions to the field of virology have reshaped our understanding of the connections between infectious and chronic diseases. PNAS recently spoke with the Nobel laureate about HPV, undercooked beef, and scientific “dogma.”pnas;109/5...
Source: Proceedings of the National Academy of Sciences - January 31, 2012 Category: Science Authors: Kolf, C. Tags: QnAs Source Type: research
Using Administrative Claims Data to Estimate Virologic Failure Rates among Human Immunodeficiency Virus-Infected Patients with Antiretroviral Regimen SwitchesEmail this article to a colleague.
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Conclusions. This claims signature model allows payers to use claims data to estimate virologic failure rates in their patient populations, thereby better understanding plan costs of failure. (Source: Medical Decision Making)
Source: Medical Decision Making - January 31, 2012 Category: Health Management Authors: Broder, M. S., Juday, T., Chang, E. Y., Jing, Y., Bentley, T. G. K. Tags: Original Articles Source Type: research
Researchers identify key peptides that could lead to a universal vaccine for influenzaEmail this article to a colleague.
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(University of Southampton) Researchers at the University of Southampton, University of Oxford and Retroscreen Virology Ltd have discovered a series of peptides, found on the internal structures of influenza viruses that could lead to the development of a universal vaccine for influenza, one that gives people immunity against all strains of the disease, including seasonal, avian, and swine flu. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 31, 2012 Category: Global & Universal Source Type: news
Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in KoreaEmail this article to a colleague.
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This study was conducted to investigate the status and population dynamics of porcine circovirus type 2 (PCV2) in Korea and
to assess the molecular evolutionary pattern of the two biologically important, overlapping open reading frames, the ORF1
and ORF3 genes. A wide range of PCV2 genomic sequences (entire genome, ORF1, ORF2 and ORF3) collected between 2001 and 2010
were analyzed using the Bayesian Markov chain Monte Carlo and maximum-likelihood approaches. These techniques identified the
PCV2d genotype and the 2Ek cluster of PCV2a in Korea for the first time. Second, the genotypic shift of PCV2b dominating over
PCV2...
Source: Archives of Virology - January 30, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infectionEmail this article to a colleague.
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During progressive HIV-1 infection, soluble HLA class I molecules can contribute to systemic immune dysfunction by inhibiting the antigen-presenting properties of myeloid dendritic cells through interactions with inhibitory myelomonocytic HLA class I receptors. (Source: Retrovirology)
Source: Retrovirology - January 30, 2012 Category: Virology Authors: Jinghe HuangMaha Al-MozainiJerome RogichMary CarringtonKatherine SeissFlorencia PereyraMathias LichterfeldXu Yu Source Type: research
Influence of HLA alleles in response to treatment with pegylated interferon‐alpha and ribavirin in patients with chronic hepatitis CEmail this article to a colleague.
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The objective of this study was to analyse the possible role of HLA polymorphism of chronically infected hepatitis C virus patients in the response outcome to treatment with pegylated interferon‐alpha plus ribavirin. To that end, 144 Brazilian patients infected only with genotype 1 of the virus were treated with pegylated interferon‐alpha at 1.5 μg kg−1 in conjunction with ribavirin (1000 mg if patient weight was <75 kg and 1250 mg if >75 kg) for 48 weeks. The patients did not have concomitant HBV or HIV infections or liver disease, did not undergo previous antiviral treatment, and were followed ...
Source: International Journal of Immunogenetics - January 30, 2012 Category: Genetics & Stem Cells Authors: A. V. MarangonR. A. MoliternoA. M. SellC. F. V. de MoraesR. M. T. GrottoM. C. PardiniD. S. De PauliJ. E. L. VisentainerG. F. Silva Source Type: research
The Importance of Accurate Diagnosis of Dengue FeverThe Importance of Accurate Diagnosis of Dengue FeverEmail this article to a colleague.
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Early diagnosis and prompt treatment is very important in dengue fever. How can we avoid diagnostic errors? Future Virology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2012 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Tracking The Birth Of An Evolutionary Arms Race Between HIV-Like Viruses And Primate GenomesEmail this article to a colleague.
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Using a combination of evolutionary biology and virology, scientists at Fred Hutchinson Cancer Research Center have traced the birth of the ability of some HIV-related viruses to defeat a newly discovered cellular-defense system in primates. The research, led by Michael Emerman, Ph.D., a member of the Hutchinson Center's Human Biology and Basic Sciences Division, and Harmit Malik, Ph.D., a member of the Center's Basic Sciences Division, was published online ahead of the Feb. 16 print issue of Cell Host & Microbe... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 29, 2012 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
Monitoring of HIV Type 1 DNA Load and Drug Resistance in Peripheral Blood Mononuclear Cells During Suppressive Antiretroviral Therapy Does Not Predict Virologic FailureEmail this article to a colleague.
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AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - January 27, 2012 Category: Infectious Diseases Tags: article Source Type: research
Epidemiology and genetic relatedness of measles virus infection in Uttar Pradesh, India, during 2009-2010Email this article to a colleague.
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This study calls for an improved surveillance
system and intensive characterization of genotypes in circulation for the measles elimination program in India.
Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00705-012-1227-9Authors
Akhalesh Kumar Shakya, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 IndiaVibha Shukla, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 IndiaHarjeet Singh Maan, Department of Microbiology, Sanjay Gandhi Postgraduate Insti...
Source: Archives of Virology - January 27, 2012 Category: Virology Tags: Archives of Virology Source Type: research
A novel mitovirus from the hypogeous ectomycorrhizal fungus Tuber excavatumEmail this article to a colleague.
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Content Type Journal ArticleCategory Annotated Sequence RecordPages 1-4DOI 10.1007/s00705-012-1228-8Authors
J. Benjamin Stielow, CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT Utrecht, The NetherlandsZoltan Bratek, Department of Plant Physiology and Molecular Plant Biology, ELTE University, Pázmány Péter sétány 1/C, Budapest, 1518 HungaryHans-Peter Klenk, DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7 B, 38124 Braunschweig, GermanyStephan Winter, DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7 B, 38124 Braunschweig, GermanyWulf Menzel, DSMZ-...
Source: Archives of Virology - January 27, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapyEmail this article to a colleague.
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In conclusion, srVSV is a promising platform for virotherapeutic approaches and also for VSV-based vector vaccines, combining
improved safety with an increased coding capacity for therapeutic transgenes, potentially allowing for multipronged approaches.
Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s00109-012-0863-6Authors
Alexander Muik, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyCatherine Dold, Institute for Virology, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, AustriaYvonne Geiß, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyAndreas Volk, Georg-S...
Source: Journal of Molecular Medicine - January 27, 2012 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: research
The genome and proteome of a Campylobacter coli bacteriophage vB_CcoM-IBB_35 reveal unusual featuresEmail this article to a colleague.
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Conclusions:
Genes encoding proteins involved in the carbohydrate metabolism along with several incidences of gene duplications, split genes with inteins and introns have been rarely found in other phage genomes yet are found in this phage. We identified the genes encoding for tail fibres and for the lytic cassette, this later, expressing enzymes for bacterial capsular polysaccharides (CPS) degradation, which has not been reported before for Campylobacter phages. (Source: Virology Journal)
Source: Virology Journal - January 27, 2012 Category: Virology Authors: Carla CarvalhoAndrew KropinskiErika LingohrSilvio SantosJonathan KingJoana Azeredo Source Type: research
The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodiesEmail this article to a colleague.
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This study indicates that the b12 W100 pocket on gp120 is targeted infrequently by CD4bs mabs. This site is therefore not a priority for preservation in vaccines aiming to elicit antibodies targeting the CD4bs. (Source: Retrovirology)
Source: Retrovirology - January 27, 2012 Category: Virology Authors: Maria Duenas-DecampOlivia O'ConnellDavide CortiSusan Zolla-PaznerPaul Clapham Source Type: research
Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivoEmail this article to a colleague.
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The findings in this work show that BST-2 restricts MMTV release from naturally infected cells and that BST-2 is an antiviral factor in vivo. (Source: Retrovirology)
Source: Retrovirology - January 27, 2012 Category: Virology Authors: Philip JonesHarshini MehtaMartina MaricRichard RollerChioma Okeoma Source Type: research
[Articles] Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort studyEmail this article to a colleague.
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A substantial improvement in viral load suppression and accompanying decrease in the rates of AIDS in people after extensive failure to drugs from the three original antiretroviral classes during 2000–09 was probably mainly driven by availability of newer drugs with better tolerability and ease of use and small cross-resistance profiles, suggesting the public health benefit of the introduction of new drugs. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - January 26, 2012 Category: Infectious Diseases Authors: The Pursuing Later Treatment Option II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Group Tags: Articles Source Type: research
Predictive value of HIV‐1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment‐experienced patientsEmail this article to a colleague.
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ConclusionsWe found no additional predictive value of replication capacity for virological or immunological responses (above what PSS provides) in patients undergoing salvage ARV treatment. (Source: HIV Medicine)
Source: HIV Medicine - January 26, 2012 Category: Infectious Diseases Authors: R BedimoT KyriakidesS BrownJ WeidlerY LieE CoakleyM Holodniy Tags: Original Research Source Type: research
Recombinant Cell Lines Expressing shRNA Targeting Herpes Simplex Virus 2 VP16 Inhibit Virus ReplicationEmail this article to a colleague.
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Intervirology (DOI:10.1159/000335663) (Source: Intervirology)
Source: Intervirology - January 26, 2012 Category: Virology Source Type: research
Meta‐analysis: antiviral treatment for hepatitis DEmail this article to a colleague.
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ConclusionsLong‐term suppression of HDV RNA by IFNa is not maintained despite an end of treatment response; adding lamivudine is not beneficial. PEG‐IFNa is superior to other medications with respect to EOT and EOFUP. New RCTs should test combinations of PEG‐IFNa and newest antivirals. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 26, 2012 Category: Drugs & Pharmacology Authors: C. TriantosM. KalafateliV. NikolopoulouA. Burroughs Tags: Meta‐Analysis Source Type: research
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1Email this article to a colleague.
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Conclusions:
These studies, which demonstrate significant increases in HIV-1 infection subsequent to application and removal of LC and CS, support plausible explanations for the failures of microbicides formulated from these compounds. Detailed studies are now underway to determine the mechanism responsible for this enhancement effect and to assess the potential contribution of this effect to the clinical failures of these agents. (Source: Virology Journal)
Source: Virology Journal - January 26, 2012 Category: Virology Authors: Vanessa PirroneShendra PassicBrian WigdahlFred Krebs Source Type: research
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical studyEmail this article to a colleague.
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ConclusionsOur study demonstrates that adding VPA to stable HAART does not reduce the latent HIV reservoir in virally suppressed patients. (Source: HIV Medicine)
Source: HIV Medicine - January 26, 2012 Category: Infectious Diseases Authors: JP RoutyCL TremblayJB AngelB TrottierD RouleauJG BarilM HarrisS TrottierJ SingerN ChomontRP SékalyMR Boulassel Tags: Original Research Source Type: research
Tracking the birth of an evolutionary arms race between HIV-like viruses and primate genomesEmail this article to a colleague.
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(Fred Hutchinson Cancer Research Center) Using a combination of evolutionary biology and virology, scientists at Fred Hutchinson Cancer Research Center have traced the birth of the ability of some HIV-related viruses to defeat a newly discovered cellular-defense system in primates. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 26, 2012 Category: Global & Universal Source Type: news
Molecular characterization of β-lactam-resistant Escherichia coli isolated from Fu River, ChinaEmail this article to a colleague.
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Abstract The present study aims to demonstrate the β-lactam resistance phenotypes and genotypes of Escherichia coli isolates from the Fu River in Chengdu, southwestern China. We obtained 108 E. coli isolates from nine sampling sites during May and December 2010. The total bacterial count varied from 79 colony-forming units
(CFU)/ml to 14,550 CFU/ml, and coliform group number from 13 to 1,435 MPN/ml. Among the 108 isolates, 0–31.48% were resistant
to β-lactams and β-lactam inhibitors, 1.85–7.40% to aminoglycoside, 1–20% to fluoroquinolone, and 50% to trimethoprim- sulfamethoxazole.
The total bact...
Source: World Journal of Microbiology and Biotechnology - January 25, 2012 Category: Microbiology Tags: World Journal of Microbiology and Biotechnology Source Type: research
TLR4 polymorphisms and disease susceptibilityEmail this article to a colleague.
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Abstract Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated
molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the
lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal to mycobacterial pathogens and some
endogenous ligands. A complex signaling cascade initiates after the ligand binds to the TLR4 ectodomain, leading to the activation
of multiple inflammatory genes. Genetic variations greatly influence immune response...
Source: Inflammation Research - January 25, 2012 Category: Research Tags: Inflammation Research Source Type: research
Patient empowerment as a component of health system reforms: rights, benefits and vested interestsEmail this article to a colleague.
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Abstract Different strategies have been developed across countries to foster citizens’ and patients’ involvement, from health policies
to patients’ active participation in decisions regarding their health. The spectrum varies from systems where patients lead
the reform of health care services, to others where a paternalistic approach still limits patients’ autonomy in decision-making.
This paper describes: (1) different interventions for involving patients; (2) experiences to promote consumer evidence-based
advocacy; and (3) barriers to consumer involvement in health system reforms, including vested ...
Source: Internal and Emergency Medicine - January 25, 2012 Category: Emergency Medicine Tags: Internal and Emergency Medicine Source Type: research
Complete nucleotide sequences of the genomes of two isolates of apple chlorotic leaf spot virus from peach (Prunus persica) in ChinaEmail this article to a colleague.
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Abstract The complete nucleotide sequences of two isolates of apple chlorotic leaf spot virus (Z1 and Z3) collected from peach in Henan
Province, China, were determined. The genomes of both Z1 and Z3 were found to contain three open reading frames (ORFs). Sequence
analysis showed that genomic sequences of Z1 and Z3 isolates shared 67.4%-82.9% and 67.2%-82.6% identity, respectively, with
the other eight isolates of ACLSV that have been reported previously. Based on the putative amino acid sequences of the products
of the three ORFs, Z1 and Z3 isolates showed the greatest identity to isolate PBM1 (GenBank acce...
Source: Archives of Virology - January 25, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Translation of MMTV Gag requires nuclear events involving splicing motifs in addition to the viral Rem protein and RmREEmail this article to a colleague.
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This paper shows that the translation of MMTV Gag mRNA is negatively regulated by a nuclear "experience" and that viral Rem protein, viral RmRE sequence,and a splice donor and acceptor are needed to counter the negative translational effect on Gag mRNA in the cytoplasm. (Source: Retrovirology)
Source: Retrovirology - January 25, 2012 Category: Virology Authors: Ioana BoerasMichael SakalianJohn West Source Type: research
Multiparametric cytometry for exploration of complex cellular dynamicsEmail this article to a colleague.
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AbstractThe development of polychromatic cytometry has contributed to significant progress in the field of human immunology. Although numerous functional studies of rare cell populations have been performed using this technology, here we used polychromatic cytometry to explore the dynamics of complex cellular systems implicated in innate immunity. We used PBMC stimulated with live influenza virus as an experimental model. We studied the time course of activation of PBMC, which contain DC, monocytes, and NK cells, all of which are, in addition to their innate immune properties, susceptible to Flu infection. We developed 12 ...
Source: Cytometry Part A - January 25, 2012 Category: Molecular Biology Authors: Françoise Gondois‐ReySamuel GranjeaudSuong Le Thi KieuDiana HerreraIvan HirschDaniel Olive Tags: Technical Note Source Type: research
Treatment outcomes in HIV-infected adolescents attending a community-based antiretroviral therapy clinic in South Africa.Email this article to a colleague.
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Background:
Very few data are available on treatment outcomes of adolescents living with HIV infection (whether perinatally acquired or sexually acquired) in sub-Saharan Africa. The present study therefore compared the treatment outcomes in adolescents with those of young adults at a public sector community-based ART programme in Cape Town, South Africa.
Methods:
Treatment outcomes of adolescents (9-19 years) were compared with those of young adults (20-28 years), enrolled in a prospective cohort between September 2002 and June 2009. Kaplan-Meier estimates and Cox proportional hazard models were used to assess outcomes and...
Source: BMC Infectious Diseases - January 25, 2012 Category: Infectious Diseases Authors: Mweete NglaziKatharina KranzerPearl HoleleRichard KaplanDaniella MarkHeather JaspanStephen LawnRobin WoodLinda-Gail Bekker Source Type: research
Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domainEmail this article to a colleague.
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Conclusion:
Our findings suggest that GPDeltaMLD presented through retroVLPs may provide a strategy for development of a vaccine against multiple ebolaviruses. Similar vaccination strategies may be adopted for other viruses whose envelope proteins contain highly variable regions that may mask more conserved domains from the immune system. (Source: Virology Journal)
Source: Virology Journal - January 25, 2012 Category: Virology Authors: Wu OuJosie DelisleJerome JacquesJoanna ShihGraeme PriceJens KuhnVivian WangDaniela VerthelyiGerardo KaplanCarolyn Wilson Source Type: research
Genomic characterization of a cell-culture-adapted Korean human G9P[8] rotavirus, CAU05-202Email this article to a colleague.
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Abstract The human rotavirus G9 strain is the fifth most common rotavirus worldwide. A human rotavirus G9P[8] strain CAU05-202 was
isolated from a young child with diarrhea using a cell culture system, and its major gene sequences were determined. Phylogenetic
analysis of the VP7 gene revealed that CAU05-202 clustered into genetic lineage III-d and was most closely related to G9 rotaviruses from Turkey
(strain GUH13) and Sri Lanka (strain 05SLC056 and 05SLC057). VP4 and NSP4 gene analysis showed that CAU05-202 belongs to the P[8]-3 lineage and genotype B, respectively. In addition, CAU05-202 has
a long RNA e...
Source: Archives of Virology - January 24, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Detection and characterisation of two novel vitiviruses infecting ActinidiaEmail this article to a colleague.
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Abstract Two co-infecting novel vitiviruses from Actinidia chinensis were identified from mechanically inoculated Nicotiana occidentalis. Both virus genomes were sequenced and share 64% nucleotide identity. Their overall structure is typical of vitiviruses,
with five open reading frames (ORFs) and a polyadenylated 3′ end. Open reading frame 4 (ORF4) encodes the coat protein, the
most conserved gene of the vitiviruses, in which they share 75% amino acid identity, 61-68% with grapevine virus B, 55-59%
with grapevine virus A, and 37-42% with grapevine virus E. Based on the molecular criteria for species demarc...
Source: Archives of Virology - January 24, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Effects of the inhibition of cytosolic phospholipase A2α in non-small cell lung cancer cellsEmail this article to a colleague.
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Conclusions Pyrrolidine-2 is a more potent and specific cPLA2α inhibitor than MAFP and AACOCF3 and represents an excellent pharmacological tool to investigate the biosynthesis and the
biological roles of cancer. The present study suggests that pyrrolidine-2 could be a potential therapeutic agent for cancer
therapy.
Content Type Journal ArticleCategory Original PaperPages 1-9DOI 10.1007/s00432-012-1157-7Authors
Shenbagamoorthy Sundarraj, Proteomics and Molecular Cell Physiology Laboratory, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore, 641046 TN, IndiaSoundarapand...
Source: Journal of Cancer Research and Clinical Oncology - January 24, 2012 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: research
Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccinesEmail this article to a colleague.
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Abstract The porcine epidemic diarrhoea virus (PEDV), a member of the Coronaviridae family, causes acute diarrhoea and dehydration
in pigs. Although it was first identified in Europe, it has become increasingly problematic in many Asian countries, including
Korea, China, Japan, the Philippines, and Thailand. The economic impacts of the PEDV are substantial, given that it results
in significant morbidity and mortality in neonatal piglets and is associated with increased costs related to vaccination and
disinfection. Recently, progress has been made in understanding the molecular epidemiology of PEDV, thereby ...
Source: Virus Genes - January 24, 2012 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: research
Complete sequence of a viral nervous necrosis virus (NNV) isolated from red-spotted grouper (Epinephelus akaara) in ChinaEmail this article to a colleague.
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Abstract A nodavirus isolated from red-spotted grouper (Epinephelus akaara) larvae in China has been subjected to genome analysis. The full-length genome sequences of RNA1 and RNA2 were determined,
and the 5′-non-coding region (NCR) and 3′NCR sequences were determined by 5′ rapid amplification of cDNA ends (RACE) and 3′RACE.
RNA1 is 3,103 nt in length and contains a 982-amino-acid open reading frame (ORF) encoding protein A with a calculated molecular
mass of 110.74 kDa. RNA2 is 1,433 nt long and contains a 338-amino-acid major ORF encoding coat protein with a calculated
molecular mass...
Source: Archives of Virology - January 24, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Analysis of the PKR-eIF2alpha phosphorylation homology domain (PePHD) of hepatitis C virus genotype 1 in HIV-coinfected patients by ultra-deep pyrosequencing and its relationship to responses to pegylated interferon-ribavirin treatmentEmail this article to a colleague.
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Abstract Chronic coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is among the greatest challenges facing
public health worldwide. In this population, the response to hepatitis C therapy by treatment with pegylated interferon plus
ribavirin (PEG-IFN+RBV) is lower than in HCV-monoinfected patients, particularly in those infected by HCV genotype 1. A PKR/eIF-2α
phosphorylation homology domain (PePHD) within the E2 protein has been found to interact with PKR and inhibit PKR in vitro, suggesting a possible mechanism for HCV to evade the antiviral effects of IFN. The aim of this wor...
Source: Archives of Virology - January 24, 2012 Category: Virology Tags: Archives of Virology Source Type: research
A new proposed taxon for double-stranded DNA viruses, the order “Ligamenvirales”Email this article to a colleague.
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Abstract Linear viruses with double-stranded DNA genomes are classified into two families, Lipothrixviridae and Rudiviridae. The members of these two families, all of which infect hyperhermophilic members of the domain Archaea, differ significantly
in the complexity of their virions as well as in their mechanisms of genome replication. However, recent structural and genomic
studies have revealed a robust evolutionary link between members of the two families. To acknowledge this relationship we
propose to unify the two families into the new taxonomic order “Ligamenvirales”.
Content Type Journal Articl...
Source: Archives of Virology - January 24, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Persistent retroviral infection with MoMuLV influences neuropathological signature and phenotype of prion diseaseEmail this article to a colleague.
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Abstract A fundamental step in pathophysiology of prion diseases is the conversion of the host encoded prion protein (PrPC) into a misfolded isoform (PrPSc) that accumulates mainly in neuronal but also non-neuronal tissues. Prion diseases are transmissible within and between species.
In a subset of prion diseases, peripheral prion uptake and subsequent transport to the central nervous system are key to disease
initiation. The involvement of retroviruses in this process has been postulated based on the findings that retroviral infections
enhance the spread of prion infectivity and PrPSc from cell to cell in vi...
Source: Acta Neuropathologica - January 24, 2012 Category: Neurology Tags: Acta Neuropathologica Source Type: research
Gastroprotective Effect of NaHS Against Mucosal Lesions Induced by Ischemia–Reperfusion Injury in RatEmail this article to a colleague.
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Conclusion Our findings indicate that a possible mechanism for the gastroprotective effect of H2S could be through the decreased mRNA expression and plasma release of proinflammatory cytokines.
Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s10620-012-2051-5Authors
Seyyed Ali Mard, Department of Physiology, Physiology Research Center (PRC), Research institute for infectious diseases of digestive system, School of Medicine, Ahvaz Jundi Shapur University of Medical Sciences, Ahvaz, IranNiloofar Neisi, Research institute for infectious diseases of digestive system and Departmen...
Source: Digestive Diseases and Sciences - January 24, 2012 Category: Gastroenterology Tags: Digestive Diseases and Sciences Source Type: research
Updates on the genetic variations of Norovirus in sporadic gastroenteritis in Chungnam Korea, 2009-2010Email this article to a colleague.
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Previously, we explored the epidemic pattern and molecular characterization of noroviruses (NoVs) isolated in Chungnam, Korea in 2008, and the present study extended these observations to 2009 and 2010. In Korea, NoVs showed the seasonal prevalence from late fall to spring, and widely detected in preschool children and peoples over 60 years of age. Epidemiological pattern of NoV was similar in 2008 and in 2010, but pattern in 2009 was affected by pandemic influenza A/H1N1 2009 virus. NoV-positive samples were subjected to sequence determination of the capsid gene region, which resolved the isolated NoVs into five GI (2, 6,...
Source: Virology Journal - January 24, 2012 Category: Virology Authors: KwiSung ParkSangGu YeoHyeSook JeongKyoungAh BaekDongUk KimMyoungHee ShinJaeHyoung SongSooJin LeeYoungJin ChoiJoonSoo ParkSungChan ChoDooSung Cheon Source Type: research
Permissiveness of human hepatoma cell lines for HCV infectionEmail this article to a colleague.
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Conclusions:
We conclude that the restrictions observed later during HCV infection in these cell lines could in part be attributed to HCV-induced innate signaling. Nevertheless, the identification of two new cell lines capable of supporting authentic HCVcc infection, even at reduced levels, expands the current repertoire of cell lines amendable for the study of HCV in vitro and should aid in further elucidating HCV biology and the cellular determinants that modulate HCV infection. (Source: Virology Journal)
Source: Virology Journal - January 24, 2012 Category: Virology Authors: Bruno SainzNaina BarrettoXuemei YuPeter CorcoranSusan Uprichard Source Type: research
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes.Email this article to a colleague.
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Conclusions:
These results suggest cholesterol trafficking and localization can profoundly affect HIV-1 infectivity by modulating the cholesterol content of the virions. (Source: Virology Journal)
Source: Virology Journal - January 24, 2012 Category: Virology Authors: Ebony ColemanTiffany WalkerJames Hildreth Source Type: research
