Virology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
17387 records returned
HIV-1 Nef: hacker of the host cell
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Future Virology , February 2012, Vol. 7, No. 2, Pages 117-120. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Ross River virus evolution: implications for vaccine developmentEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 173-178. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
AcknowledgementsEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 215-215. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Progress in DNA vaccination against HBV infectionEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 149-160. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Highlights of the 27th International Papillomavirus Conference and Clinical Workshop: part 3: epidemiology and public healthEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 127-133. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Proteomics-related biomarkers for HBV-associated hepatocellular carcinoma: current status and future prospectsEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 161-171. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Bulletin BoardEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 121-125. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Viral subversion of host functions for picornavirus translation and RNA replicationEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 179-191. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
The effect of alcohol use on IL-6 responses across different racial/ethnic groupsEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 205-213. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Consequences of persistent HBV infection in HIV: the double-edged sword of nucleos(t)ide analogsEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 139-148. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Diversity and compartmentalization of persistent HIV-1 reservoirs under suppressive antiretroviral therapyEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 135-137. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Race and CD4+ T-cell count in HIV prognosis and treatmentEmail this article to a colleague.
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Future Virology , February 2012, Vol. 7, No. 2, Pages 193-203. (Source: Future Virology)
Source: Future Virology - February 6, 2012 Category: Virology Tags: article Source Type: research
Nigeria: HIV Treatment Vaccine Expected in Five Years - InstituteEmail this article to a colleague.
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[Daily Trust]
The Institute of Human Virology, Nigeria (IHVN), says vaccine for treatment of Human Immuno-deficiency Virus that causes AIDS, may be available in the next five years. (Source: AllAfrica News: Health and Medicine)
Source: AllAfrica News: Health and Medicine - February 6, 2012 Category: African Health Source Type: news
Presence of precore and core promoter mutants limits the probability of response to peginterferon in HBeAg‐positive chronic hepatitis BEmail this article to a colleague.
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Conclusion:Presence of only WT virus at baseline is a strong predictor of response (HBeAg loss with HBV DNA <10,000 copies/mL) to PEG‐IFN for HBeAg‐positive CHB. Patients with detectable PC and/or BCP mutants have a lower probability of response and are less optimal candidates for PEG‐IFN therapy. (HEPATOLOGY 2012.) (Source: Hepatology)
Source: Hepatology - February 6, 2012 Category: Internal Medicine Authors: Milan J. SonneveldVincent RijckborstStefan ZeuzemE. Jenny HeathcoteKrzysztof SimonHakan SenturkSuzan D. PasBettina E. HansenHarry L.A. Janssen Tags: Viral Hepatitis Source Type: research
Dominance of resistance-breaking cotton leaf curl Burewala virus (CLCuBuV) in northwestern IndiaEmail this article to a colleague.
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This study shows that the resistance-breaking cotton leaf curl Burewala virus (CLCuBuV) is now the dominant virus in many
fields. The spread and establishment of the mutant CLCuBuV in northwestern India, the variation in its genomic sequence, its
virulence and infectivity, and the implications for cotton breeding are discussed.
Content Type Journal ArticleCategory Original ArticlePages 1-14DOI 10.1007/s00705-012-1225-yAuthors
Prem A. Rajagopalan, Plant-Virus Interactions Lab, Mahyco Research Center, Maharashtra Hybrid Seeds Company Limited, Dawalwadi, Post Box no-76, Jalna, Maharashtra 431 203, IndiaAmruta Naik, P...
Source: Archives of Virology - February 3, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Characterization of Epstein-Barr virus type 1 nuclear antigen 3C sequence patterns of nasopharyngeal and gastric carcinomas in northern ChinaEmail this article to a colleague.
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In this study, we successfully amplified 26 Epstein-Barr virus (EBV)-associated
gastric carcinomas (EBVaGCs), 50 nasopharyngeal carcinomas (NPCs) and 27 throat washing (TW) samples from healthy donors.
Based on a phylogenetic tree, the samples could be divided into three patterns. 3C-6 was the predominant subtype in northern
China, and the variations between the strains sequenced in our study and those from southern China and Japan were similar,
but differences were also identified. The distribution of EBNA3C subtypes among EBVaGCs, NPCs and healthy donors was not significantly
different. These data suggest that EBNA3...
Source: Archives of Virology - February 2, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Development of a novel real-time PCR-based strategy for simple and rapid molecular pathotyping of Newcastle disease virusEmail this article to a colleague.
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Abstract A novel real-time PCR strategy was applied to simultaneously detect and to discriminate low-pathogenic lentogenic and virulent
meso/velogenic Newcastle disease virus (NDV). The pathotyping is achieved by a three-step semi-nested PCR. A pre-amplification
of the cleavage site (CS) region of the F gene is followed by a two-level duplex real-time PCR directly targeting the CS,
combining detection and pathotyping in a single tube. A wide range of NDV isolates spanning all genotypes were successfully
detected and pathotyped. Clinical samples from outbreaks in Sweden in 2010 that were positive by the novel...
Source: Archives of Virology - February 2, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Key Peptides Identified That Could Lead To A Universal Vaccine For InfluenzaEmail this article to a colleague.
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Researchers at the University of Southampton, University of Oxford and Retroscreeen Virology Ltd have discovered a series of peptides, found on the internal structures of influenza viruses that could lead to the development of a universal vaccine for influenza, one that gives people immunity against all strains of the disease, including seasonal, avian, and swine flu. Influenza, an acute viral infection, affects hundreds of thousands of people a year and puts an enormous strain on healthcare providers globally... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 2, 2012 Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news
Construction of an infectious cDNA clone of Culex flavivirus, an insect-specific flavivirus from Culex mosquitoesEmail this article to a colleague.
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Abstract Culex flavivirus (CxFV) is an insect-specific flavivirus that has recently been detected in various Culex spp. mosquitoes worldwide. Here, we report the successful construction of a full-length infectious cDNA clone of a Tokyo
strain, CxFV-NIID21. The full-length CxFV-NIID21 cDNA was cloned into the low-copy-number plasmid pMW119, which was stably
amplified in Escherichia coli. Transfection of a mosquito cell line with in vitro-transcribed RNA from the cDNA clone resulted in the production of recombinant progeny virus with growth properties, cytopathogenicity,
and virion morphology similar to the par...
Source: Archives of Virology - February 2, 2012 Category: Virology Tags: Archives of Virology Source Type: research
A transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against porcine reproductive and respiratory syndrome virusEmail this article to a colleague.
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In this study, we designed 5 of the small hairpin RNAs (shRNAs) targeting the GP5 and M gene of PRRSV
respectively, and investigated their inhibition to the production of PRRSV. The highest activity displayed in shRNAs of the
ORF6e sequence (nts 261-279), which the inhibition rate reached was 99.09%. The result suggests that RNAi technology might
serve as a potential molecular strategy for PRRSV therapy. Furthermore, the transgenic Marc-145 cell line of piggyBac transposon-derived targeting shRNA interference against PRRS virus was established. It presented stable inhibition to
the replication and amplification of PRRS...
Source: Veterinary Research Communications - February 1, 2012 Category: Veterinary Research Tags: Veterinary Research Communications Source Type: research
Antiviral function and efficacy of polyvalent immunoglobulin products against CMV isolates in different human cell linesEmail this article to a colleague.
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This study suggests different antiviral
functions of polyvalent IVIG and confirms their potential to inhibit a CMV infection in vitro, with profound differences between
the hereby used IVIG products.
Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00430-012-0229-2Authors
K. Frenzel, Institute of Medical Virology, Helmut-Ruska-Haus, Charité University Medicine, Charitéplatz 1, 10117 Berlin, GermanyS. Ganepola, Department of Haematology, Oncology and Transfusion Medicine, Charité University Medicine, Berlin, GermanyD. Michel, Institute of Virology, University Hospital Ulm, Ulm, GermanyE....
Source: Medical Microbiology and Immunology - February 1, 2012 Category: Microbiology Tags: Medical Microbiology and Immunology Source Type: research
Influenza vaccination of healthcare workers in acute-care hospitals: a case-control study of its effect on hospital-acquired influenza among patientsEmail this article to a colleague.
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Conclusions:
Our observational study indicates a shielding effect of more than 35% of vaccinated HCW on HAI among patients in acute-care units. Investigations, such as controlled clinical trials, are needed to validate the benefits of HCW vaccination on HAI incidence in patients. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - February 1, 2012 Category: Infectious Diseases Authors: Thomas BenetCorinne RegisNicolas VoirinOlivier RobertBruno LinaSilene CronenbergerBrigitte ComteBrigitte CopperePhilippe Vanhems Source Type: research
UK consensus guidelines for the use of the protease inhibitors boceprevir and telaprevir in genotype 1 chronic hepatitis C infected patientsEmail this article to a colleague.
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ConclusionsThese UK Consensus guidelines indicate the current best practice for the use of boceprevir and telaprevir in the management of genotype 1 chronic HCV infection. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - February 1, 2012 Category: Drugs & Pharmacology Authors: P. RamachandranA. FraserK. AgarwalA. AustinA. BrownG. R. FosterR. FoxP. C. HayesC. LeenP. R. MillsD. J. MutimerS. D. RyderJ. F. Dillon Tags: Original Article Source Type: research
A DNA vaccine expressing PB1 protein of influenza A virus protects mice against virus infectionEmail this article to a colleague.
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Abstract Although influenza DNA vaccine research has focused mainly on viral hemagglutinin and has led to promising results, other
virion proteins have also shown some protective potential. In this work, we explored the potential of a DNA vaccine based
on the PB1 protein to protect BALB/c mice against lethal influenza A virus infection. The DNA vaccine consisted of pTriEx4
plasmid expressing PB1. As a positive control, a pTriEx4 plasmid expressing influenza A virus HA was used. Two weeks after
three subcutaneous doses of DNA vaccine, the mice were challenged intranasally with 1 LD50 of A/Puerto Rico/8/34 (H1...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Superiority of the buffy coat over serum or plasma for the detection of Alkhumra virus RNA using real time RT-PCREmail this article to a colleague.
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In this study, RT-PCR detection of viral RNA from the plasma, serum, and buffy coat (BC)
was compared to virus isolation. Plasma, serum, and BC were obtained from seven patients with clinically suspected ALKV infection
in Najran, Saudi Arabia. Baby hamster kidney (BHK-21) and rhesus monkey kidney (LLC-MK2) cell culture monolayers were used
for virus isolation. Real-time RT-PCR was used to confirm ALKV infection and to detect viral RNA directly from plasma, serum,
and BC. ALKV was isolated from five of the seven patients. The virus was isolated from all three specimen types (plasma, serum,
and BC) of the five confirmed...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in GreeceEmail this article to a colleague.
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Abstract The E2 gene of human papilloma virus is expressed at the early stage of the viral life cycle, encoding the E2 transcription
factor, and regulates the expression of E6 and E7 oncogenes. Disruption of E2 gene due to viral integration inhibits the transcriptional
suppression of the HPV oncogenes, inducing cell proliferation. In the present study, a total of 22 HPV16-positive cytological
specimens derived from high- and low-grade cervical intraepithelial lesions were investigated in order to identify sequence
variations in the HPV16 E2 ORF. The E2 gene was amplified by PCR using external and internal ov...
Source: Archives of Virology - January 31, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Relevance of MET activation and genetic alterations of KRAS and E-cadherin for cetuximab sensitivity of gastric cancer cell linesEmail this article to a colleague.
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Conclusion These data indicate that our examinations may be clinically relevant, and the candidate markers should therefore be tested
in clinical studies.
Content Type Journal ArticleCategory Original PaperPages 1-16DOI 10.1007/s00432-011-1128-4Authors
Stefan Heindl, Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, Trogerstr. 18, 81675 Munich, GermanyEvelyn Eggenstein, Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Klinikum rechts der Isar, Trogerstr. 18, 81675 Munich, Germany...
Source: Journal of Cancer Research and Clinical Oncology - January 31, 2012 Category: Cancer & Oncology Tags: Journal of Cancer Research and Clinical Oncology Source Type: research
QnAs with Harald zur Hausen [QnAs]Email this article to a colleague.
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The first carcinogenic virus was discovered in chickens in 1911. More than 70 years later, Harald zur Hausen demonstrated that human papillomavirus (HPV) can cause cervical cancer, for which he garnered the 2008 Nobel Prize in Medicine or Physiology. A professor emeritus at the German Cancer Research Center and recently elected member of the National Academy of Sciences, zur Hausen’s contributions to the field of virology have reshaped our understanding of the connections between infectious and chronic diseases. PNAS recently spoke with the Nobel laureate about HPV, undercooked beef, and scientific “dogma.”pnas;109/5...
Source: Proceedings of the National Academy of Sciences - January 31, 2012 Category: Science Authors: Kolf, C. Tags: QnAs Source Type: research
Using Administrative Claims Data to Estimate Virologic Failure Rates among Human Immunodeficiency Virus-Infected Patients with Antiretroviral Regimen SwitchesEmail this article to a colleague.
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Conclusions. This claims signature model allows payers to use claims data to estimate virologic failure rates in their patient populations, thereby better understanding plan costs of failure. (Source: Medical Decision Making)
Source: Medical Decision Making - January 31, 2012 Category: Health Management Authors: Broder, M. S., Juday, T., Chang, E. Y., Jing, Y., Bentley, T. G. K. Tags: Original Articles Source Type: research
Researchers identify key peptides that could lead to a universal vaccine for influenzaEmail this article to a colleague.
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(University of Southampton) Researchers at the University of Southampton, University of Oxford and Retroscreen Virology Ltd have discovered a series of peptides, found on the internal structures of influenza viruses that could lead to the development of a universal vaccine for influenza, one that gives people immunity against all strains of the disease, including seasonal, avian, and swine flu. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 31, 2012 Category: Global & Universal Source Type: news
Population dynamics and ORF3 gene evolution of porcine circovirus type 2 circulating in KoreaEmail this article to a colleague.
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This study was conducted to investigate the status and population dynamics of porcine circovirus type 2 (PCV2) in Korea and
to assess the molecular evolutionary pattern of the two biologically important, overlapping open reading frames, the ORF1
and ORF3 genes. A wide range of PCV2 genomic sequences (entire genome, ORF1, ORF2 and ORF3) collected between 2001 and 2010
were analyzed using the Bayesian Markov chain Monte Carlo and maximum-likelihood approaches. These techniques identified the
PCV2d genotype and the 2Ek cluster of PCV2a in Korea for the first time. Second, the genotypic shift of PCV2b dominating over
PCV2...
Source: Archives of Virology - January 30, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Novel monoclonal antibodies for identification of multicentric Castleman's disease; Kaposi's sarcoma-associated herpesvirus-encoded vMIP-I and vMIP-II.Email this article to a colleague.
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Abstract
Recent studies have indicated that vMIP-I and vMIP-II play important roles in the pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV)-related diseases due to the effects of these proteins on vascularization. We developed monoclonal antibodies against KSHV-encoded viral macrophage inflammatory protein-I (vMIP-I) and vMIP-II to study these expression profiles and reveal the pathogenesis of KSHV-related diseases. The MAbs against vMIP-I and vMIP-II reacted to KSHV-infected cell lines after lytic induction. Both vMIP-I and the vMIP-II gene products were detected 24h post-induction with 12-O-tetradec...
Source: Virology - January 30, 2012 Category: Virology Authors: Nakano K, Katano H, Tadagaki K, Sato Y, Ohsaki E, Mori Y, Yamanishi K, Ueda K Tags: Virology Source Type: research
Systemic inhibition of myeloid dendritic cells by circulating HLA class I molecules in HIV-1 infectionEmail this article to a colleague.
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During progressive HIV-1 infection, soluble HLA class I molecules can contribute to systemic immune dysfunction by inhibiting the antigen-presenting properties of myeloid dendritic cells through interactions with inhibitory myelomonocytic HLA class I receptors. (Source: Retrovirology)
Source: Retrovirology - January 30, 2012 Category: Virology Authors: Jinghe HuangMaha Al-MozainiJerome RogichMary CarringtonKatherine SeissFlorencia PereyraMathias LichterfeldXu Yu Source Type: research
Influence of HLA alleles in response to treatment with pegylated interferon‐alpha and ribavirin in patients with chronic hepatitis CEmail this article to a colleague.
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The objective of this study was to analyse the possible role of HLA polymorphism of chronically infected hepatitis C virus patients in the response outcome to treatment with pegylated interferon‐alpha plus ribavirin. To that end, 144 Brazilian patients infected only with genotype 1 of the virus were treated with pegylated interferon‐alpha at 1.5 μg kg−1 in conjunction with ribavirin (1000 mg if patient weight was <75 kg and 1250 mg if >75 kg) for 48 weeks. The patients did not have concomitant HBV or HIV infections or liver disease, did not undergo previous antiviral treatment, and were followed ...
Source: International Journal of Immunogenetics - January 30, 2012 Category: Genetics & Stem Cells Authors: A. V. MarangonR. A. MoliternoA. M. SellC. F. V. de MoraesR. M. T. GrottoM. C. PardiniD. S. De PauliJ. E. L. VisentainerG. F. Silva Source Type: research
The Importance of Accurate Diagnosis of Dengue FeverThe Importance of Accurate Diagnosis of Dengue FeverEmail this article to a colleague.
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Early diagnosis and prompt treatment is very important in dengue fever. How can we avoid diagnostic errors? Future Virology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 29, 2012 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
Tracking The Birth Of An Evolutionary Arms Race Between HIV-Like Viruses And Primate GenomesEmail this article to a colleague.
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Using a combination of evolutionary biology and virology, scientists at Fred Hutchinson Cancer Research Center have traced the birth of the ability of some HIV-related viruses to defeat a newly discovered cellular-defense system in primates. The research, led by Michael Emerman, Ph.D., a member of the Hutchinson Center's Human Biology and Basic Sciences Division, and Harmit Malik, Ph.D., a member of the Center's Basic Sciences Division, was published online ahead of the Feb. 16 print issue of Cell Host & Microbe... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 29, 2012 Category: Consumer Health News Tags: HIV / AIDS Source Type: news
Monitoring of HIV Type 1 DNA Load and Drug Resistance in Peripheral Blood Mononuclear Cells During Suppressive Antiretroviral Therapy Does Not Predict Virologic FailureEmail this article to a colleague.
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AIDS Research and Human Retroviruses , Vol. 0, No. 0. (Source: AIDS Research and Human Retroviruses)
Source: AIDS Research and Human Retroviruses - January 27, 2012 Category: Infectious Diseases Tags: article Source Type: research
Epidemiology and genetic relatedness of measles virus infection in Uttar Pradesh, India, during 2009-2010Email this article to a colleague.
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This study calls for an improved surveillance
system and intensive characterization of genotypes in circulation for the measles elimination program in India.
Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00705-012-1227-9Authors
Akhalesh Kumar Shakya, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 IndiaVibha Shukla, Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226 014 IndiaHarjeet Singh Maan, Department of Microbiology, Sanjay Gandhi Postgraduate Insti...
Source: Archives of Virology - January 27, 2012 Category: Virology Tags: Archives of Virology Source Type: research
A novel mitovirus from the hypogeous ectomycorrhizal fungus Tuber excavatumEmail this article to a colleague.
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Content Type Journal ArticleCategory Annotated Sequence RecordPages 1-4DOI 10.1007/s00705-012-1228-8Authors
J. Benjamin Stielow, CBS-KNAW Fungal Biodiversity Centre, Uppsalalaan 8, 3584 CT Utrecht, The NetherlandsZoltan Bratek, Department of Plant Physiology and Molecular Plant Biology, ELTE University, Pázmány Péter sétány 1/C, Budapest, 1518 HungaryHans-Peter Klenk, DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7 B, 38124 Braunschweig, GermanyStephan Winter, DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7 B, 38124 Braunschweig, GermanyWulf Menzel, DSMZ-...
Source: Archives of Virology - January 27, 2012 Category: Virology Tags: Archives of Virology Source Type: research
Semireplication-competent vesicular stomatitis virus as a novel platform for oncolytic virotherapyEmail this article to a colleague.
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In conclusion, srVSV is a promising platform for virotherapeutic approaches and also for VSV-based vector vaccines, combining
improved safety with an increased coding capacity for therapeutic transgenes, potentially allowing for multipronged approaches.
Content Type Journal ArticleCategory Original ArticlePages 1-12DOI 10.1007/s00109-012-0863-6Authors
Alexander Muik, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyCatherine Dold, Institute for Virology, Innsbruck Medical University, Fritz-Pregl-Str. 3, A-6020 Innsbruck, AustriaYvonne Geiß, Georg-Speyer-Haus, 60596 Frankfurt am Main, GermanyAndreas Volk, Georg-S...
Source: Journal of Molecular Medicine - January 27, 2012 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: research
The genome and proteome of a Campylobacter coli bacteriophage vB_CcoM-IBB_35 reveal unusual featuresEmail this article to a colleague.
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Conclusions:
Genes encoding proteins involved in the carbohydrate metabolism along with several incidences of gene duplications, split genes with inteins and introns have been rarely found in other phage genomes yet are found in this phage. We identified the genes encoding for tail fibres and for the lytic cassette, this later, expressing enzymes for bacterial capsular polysaccharides (CPS) degradation, which has not been reported before for Campylobacter phages. (Source: Virology Journal)
Source: Virology Journal - January 27, 2012 Category: Virology Authors: Carla CarvalhoAndrew KropinskiErika LingohrSilvio SantosJonathan KingJoana Azeredo Source Type: research
The W100 pocket on HIV-1 gp120 penetrated by b12 is not a target for other CD4bs monoclonal antibodiesEmail this article to a colleague.
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This study indicates that the b12 W100 pocket on gp120 is targeted infrequently by CD4bs mabs. This site is therefore not a priority for preservation in vaccines aiming to elicit antibodies targeting the CD4bs. (Source: Retrovirology)
Source: Retrovirology - January 27, 2012 Category: Virology Authors: Maria Duenas-DecampOlivia O'ConnellDavide CortiSusan Zolla-PaznerPaul Clapham Source Type: research
Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivoEmail this article to a colleague.
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The findings in this work show that BST-2 restricts MMTV release from naturally infected cells and that BST-2 is an antiviral factor in vivo. (Source: Retrovirology)
Source: Retrovirology - January 27, 2012 Category: Virology Authors: Philip JonesHarshini MehtaMartina MaricRichard RollerChioma Okeoma Source Type: research
[Articles] Trends in virological and clinical outcomes in individuals with HIV-1 infection and virological failure of drugs from three antiretroviral drug classes: a cohort studyEmail this article to a colleague.
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A substantial improvement in viral load suppression and accompanying decrease in the rates of AIDS in people after extensive failure to drugs from the three original antiretroviral classes during 2000–09 was probably mainly driven by availability of newer drugs with better tolerability and ease of use and small cross-resistance profiles, suggesting the public health benefit of the introduction of new drugs. (Source: The Lancet Infectious Diseases)
Source: The Lancet Infectious Diseases - January 26, 2012 Category: Infectious Diseases Authors: The Pursuing Later Treatment Option II (PLATO II) project team for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) Group Tags: Articles Source Type: research
Predictive value of HIV‐1 replication capacity and phenotypic susceptibility scores in antiretroviral treatment‐experienced patientsEmail this article to a colleague.
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ConclusionsWe found no additional predictive value of replication capacity for virological or immunological responses (above what PSS provides) in patients undergoing salvage ARV treatment. (Source: HIV Medicine)
Source: HIV Medicine - January 26, 2012 Category: Infectious Diseases Authors: R BedimoT KyriakidesS BrownJ WeidlerY LieE CoakleyM Holodniy Tags: Original Research Source Type: research
Recombinant Cell Lines Expressing shRNA Targeting Herpes Simplex Virus 2 VP16 Inhibit Virus ReplicationEmail this article to a colleague.
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Intervirology (DOI:10.1159/000335663) (Source: Intervirology)
Source: Intervirology - January 26, 2012 Category: Virology Source Type: research
Meta‐analysis: antiviral treatment for hepatitis DEmail this article to a colleague.
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ConclusionsLong‐term suppression of HDV RNA by IFNa is not maintained despite an end of treatment response; adding lamivudine is not beneficial. PEG‐IFNa is superior to other medications with respect to EOT and EOFUP. New RCTs should test combinations of PEG‐IFNa and newest antivirals. (Source: Alimentary Pharmacology and Therapeutics)
Source: Alimentary Pharmacology and Therapeutics - January 26, 2012 Category: Drugs & Pharmacology Authors: C. TriantosM. KalafateliV. NikolopoulouA. Burroughs Tags: Meta‐Analysis Source Type: research
Cellular transformation by human papillomaviruses: Lessons learned by comparing high- and low-risk viruses.Email this article to a colleague.
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Abstract
The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s yet the mechanisms of virally-mediated cellular transformation are still being revealed. Reasons for this include: a) the oncoproteins are multifunctional, b) there is an ever-growing list of cellular interacting proteins, c) more than one cellular protein may bind to a given region of the oncoprotein, and d) there is only limited information on the proteins encoded by the corresponding non-oncogenic PVs. The perspective of this review will be to contrast the activities of the viral E6 and E7 proteins encoded by the onco...
Source: Virology - January 26, 2012 Category: Virology Authors: Klingelhutz AJ, Roman A Tags: Virology Source Type: research
Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1Email this article to a colleague.
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Conclusions:
These studies, which demonstrate significant increases in HIV-1 infection subsequent to application and removal of LC and CS, support plausible explanations for the failures of microbicides formulated from these compounds. Detailed studies are now underway to determine the mechanism responsible for this enhancement effect and to assess the potential contribution of this effect to the clinical failures of these agents. (Source: Virology Journal)
Source: Virology Journal - January 26, 2012 Category: Virology Authors: Vanessa PirroneShendra PassicBrian WigdahlFred Krebs Source Type: research
Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV‐1 reservoirs: results from a multicentre randomized clinical studyEmail this article to a colleague.
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ConclusionsOur study demonstrates that adding VPA to stable HAART does not reduce the latent HIV reservoir in virally suppressed patients. (Source: HIV Medicine)
Source: HIV Medicine - January 26, 2012 Category: Infectious Diseases Authors: JP RoutyCL TremblayJB AngelB TrottierD RouleauJG BarilM HarrisS TrottierJ SingerN ChomontRP SékalyMR Boulassel Tags: Original Research Source Type: research
