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This page shows you the most recent publications within this specialty of the MedWorm directory.

Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland
A PCR screen of soricine shrews captured over three years in Poland identified a new hantavirus, Boginia virus, with unknown pathogenic potential. (Source: Virology Journal)
Source: Virology Journal - May 22, 2013 Category: Virology Authors: Se GuJanusz MarkowskiHae KangJanusz HejdukBeata SikorskaPawe¿ LiberskiRichard Yanagihara Source Type: research

Multicenter experience using telaprevir or boceprevir with peginterferon and ribavirin to treat hepatitis C genotype 1 after liver transplantation
In conclusion, TVR or BOC combined with Peg‐IFN/RBV achieved on‐treatment virological response rates of approximately 50‐60% in patients with recurrent HCV after LT but significant side‐effects were common. Liver Transpl, 2013. © 2013 AASLD. (Source: Liver Transplantation)
Source: Liver Transplantation - May 21, 2013 Category: Transplant Surgery Authors: Surakit Pungpapong, Bashar A. Aqel, Ludi Koning, Jennifer L. Murphy, Tanisha M. Henry, Kristen L. Ryland, Maria L. Yataco, Raj Satyanarayana, Barry G. Rosser, Hugo E. Vargas, Michael R. Charlton, Andrew P. Keaveny Tags: Original Article Source Type: research

Depletion of polycistronic transcripts using short interfering RNAs: cDNA synthesis method affects levels of non-targeted genes determined by quantitative PCR
Conclusions: These data emphasise the importance of the cDNA synthesis method used when measuring transcript abundance following siRNA depletion of polycistronic transcripts. They provide a partial explanation for erroneous reports suggesting that siRNAs targeting HPV E7 can have gene-specific effects. (Source: Virology Journal)
Source: Virology Journal - May 21, 2013 Category: Virology Authors: Jennifer HanningIan GrovesMark PettNicholas Coleman Source Type: research

Induction of cytopathic effect and cytokines in coxsackievirus B3-infected murine astrocytes
Conclusion: These data suggest that direct astrocyte damage and cytokines induction could be a mechanism of virus-induced meningitis and/or encephalitis. (Source: Virology Journal)
Source: Virology Journal - May 21, 2013 Category: Virology Authors: Jun ZengGefei WangWeizhong LiDangui ZhangXiaoxuan ChenGang XinZhiwu JiangKangsheng Li Source Type: research

Comparative pathogenesis of type 1 (European genotype) and type 2 (North American genotype) porcine reproductive and respiratory syndrome virus in infected boar
Conclusions: The results of this study demonstrated that two genotypes of PRRSV do not have significantly different virulence toward the male reproductive system of pigs. (Source: Virology Journal)
Source: Virology Journal - May 21, 2013 Category: Virology Authors: Kiwon HanHwi SeoChanghoon ParkYeonsu OhIkjae KangChanhee Chae Source Type: research

Interferon-alpha (IFN-alpha) suppresses HTLV-1 gene expression and cell cycling, while IFN-alpha combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells
Conclusions: IFN-alpha suppressed HTLV-1 gene expression at least through a PKR-mediated mechanism, and also induced cell cycle arrest in ILTs. In combination with AZT, IFN-alpha further induced p53 signaling and cell apoptosis in these cells. These findings suggest that HTLV-1-infected cells at an IL-2-dependent stage retain susceptibility to type I IFN-mediated regulation of viral expression, and partly explain how AZT/IFN-alpha produces therapeutic effects in ATL. (Source: Retrovirology)
Source: Retrovirology - May 20, 2013 Category: Virology Authors: Shuichi KinparaMami KijiyamaAyako TakamoriAtsuhiko HasegawaAmane SasadaTakao MasudaYuetsu TanakaAtae UtsunomiyaMari Kannagi Source Type: research

Isolation and analysis of a very virulent Marek's disease virus strain in china
Conclusions: MDV strain SD2012-1 isolated from Shandong Province, China was found to have the characteristics of very virulent MDV-1, which could break through the protection provided by HVT vaccine and HVT + SB-1 vaccine, the virus seemed to have a long latent period, and cause different gross postmortem lesions of chickens between chickens died early and later. A better immunization way should be chosen to prevent infection of this MDV strain in field. (Source: Virology Journal)
Source: Virology Journal - May 20, 2013 Category: Virology Authors: Zhenhua GongLijuan ZhangJianlin WangLinlin ChenHu ShanZhiliang WangHongchao Ma Source Type: research

The role of indoleamine 2,3-dioxygenase in LP-BPM5 murine retroviral disease progression
Conclusions: Collectively, these results demonstrate IDO neither plays an essential role, nor is required, in LP-BM5-induced disease progression or LP-BM5 viral load. (Source: Virology Journal)
Source: Virology Journal - May 17, 2013 Category: Virology Authors: Megan O¿ConnorWilliam Green Source Type: research

[Perspective] Virology: Our Viral Inheritance
Viruses incorporated into vertebrate genomes may reemerge after long periods of dormancy to play a range of biological roles in their host.Authors: Robin A. Weiss, Jonathan P. Stoye (Source: Science: Current Issue)
Source: Science: Current Issue - May 16, 2013 Category: Science Authors: Robin A. Weiss Source Type: research

Initiation of human astrovirus type 1 infection was blocked by inhibitors of phosphoinositide 3-kinase
Conclusions: Our results reveal a previously unknown, essential role of PI3K in the life cycle of HAstV1. PI3K participates in the early stage of infection, possibly during the viral entry process. Our results also reveal the role of PKA in viral production. (Source: Virology Journal)
Source: Virology Journal - May 16, 2013 Category: Virology Authors: Shoichiro TangeYan ZhouYuko Nagakui-NoguchiTakeshi ImaiAkira Nakanishi Source Type: research

Co-treatment with arsenic trioxide and ganciclovir reduces tumor volume in a murine xenograft model of nasopharyngeal carcinoma
We have previously shown that disruption of promyelocytic leukemia nuclear bodies (PML NBs) is sufficient to activate the EBV lytic cycle thus making infected cells susceptible to ganciclovir (GCV) mediated killing in vitro. Here we show that co-administration of GCV and arsenic trioxide (ATO), a PML NB disruptor, reduces tumor volume in a xenograft model of nasopharyngeal carcinoma utilizing CNE1 cells. When administered at pharmacologic levels, both GCV and ATO reduced tumor growth while co-treatment with GCV + ATO resulted in a diminution of tumor volume. Treatment with GCV or ATO individually resulted in an increased n...
Source: Virology Journal - May 16, 2013 Category: Virology Authors: Mark SidesMeredith SosulskiFayong LuoZhen LinErik FlemingtonJoseph Lasky Source Type: research

Heterogenous nuclear ribonucleoprotein Q increases protein expression from HIV-1 Rev dependent transcripts.
Conclusion: Our data indicate that hnRNP Q can stimulate the protein production of Rev-dependent mRNAs without changing mRNA levels and mRNA export, respectively. This suggests that hnRNP Q can boost HIV gene expression at the level of protein production. (Source: Virology Journal)
Source: Virology Journal - May 16, 2013 Category: Virology Authors: Michelle VincendeauDaniel NagelJara BrenkeRuth Brack-WernerKamyar Hadian Source Type: research

Genetic diversity of HA1 domain of heammaglutinin gene of influenza A(H1N1)pdm09 in Tunisia
We present major results concerning isolation and determination of the nucleotide sequence of hemagglutinin (HA1) of the pandemic (H1N1)pdm09 influenza viruses found in Tunisia. Amino acid analysis revealed minor amino acid changes in the antigenic or receptor-binding domains. We found mutations that were also present in 1918 pandemic virus, which includes S183P in 4 and S185T mutation in 19 of 27 viruses analyzed from 2011, while none of the 2009 viruses carried these mutations. Also two specific amino acid differences into N-glycosylation sites (N288T and N276H) were detected. The phylogenetic analysis revealed that the ...
Source: Virology Journal - May 16, 2013 Category: Virology Authors: Awatef El MoussiMohamed Ali Ben Hadj KacemFrancisco PozoJuan LedesmaMaria Teresa CuevasInmaculada CasasAmine Slim Source Type: research

Evidence of host adaptation of avian-origin influenza A virus
This study will be published on Science China Life Sciences 2013, No.6. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 15, 2013 Category: Global & Universal Source Type: news

Virological rebound in HIV‐infected patients with or without residual viraemia: results from an extended follow‐up
This article is protected by copyright. All rights reserved. (Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - May 15, 2013 Category: Microbiology Authors: Nicola Gianotti, Laura Galli, Stefania Salpietro, Massimo Cernuschi, Simona Bossolasco, Myriam Maillard, Vincenzo Spagnuolo, Filippo Canducci, Massimo Clementi, Adriano Lazzarin, Antonella Castagna Tags: Research Note Source Type: research

Risk factors associated with severe manifestations of 2009 pandemic influenza A (H1N1) infection in China: a case¿control study
Conclusion: We provide evidence on the risk factors associated with severe manifestations of 2009 pandemic H1N1 influenza in a study of hospitalized subjects in China. (Source: Virology Journal)
Source: Virology Journal - May 15, 2013 Category: Virology Authors: Yan-yan RenYu-yan YinWen-qing LiYi LinTi LiuShuang WangSheng-yang ZhangZhong LiXian-jun WangZhen-qiang Bi Source Type: research

Prevalence of pre-existing resistance-associated mutations to rilpivirine, emtricitabine and tenofovir in antiretroviral-naive patients infected with B and non-B subtype HIV-1 viruses
Conclusions The prevalence of rilpivirine, emtricitabine and tenofovir resistance mutations was very low in antiretroviral-naive patients. The prevalence of resistance to rilpivirine (4.9%, n = 84) was not statistically different from the prevalence of efavirenz and nevirapine resistance in our population. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Lambert-Niclot, S., Charpentier, C., Storto, A., Fofana, D. B., Soulie, C., Fourati, S., Visseaux, B., Wirden, M., Morand-Joubert, L., Masquelier, B., Flandre, P., Calvez, V., Descamps, D., Marcelin, A.- G. Tags: Original research Source Type: research

Evolution and viral characteristics of a long-term circulating resistant HIV-1 strain in a cluster of treatment-naive patients
Conclusions Long-term circulation transcending distinct regions and transmission groups suggests reversion occurred in previous hosts in the transmission chain. Identification of clusters using epidemiological data and active-partner tracing may broaden therapeutic options in cases of transmitted resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Hofstra, L. M., Nijhuis, M., Pingen, M., Mudrikova, T., Riezebos-Brilman, A., Simoons-Smit, A. M., Van Ham, P. M., Bierman, W. F. W., Wensing, A. M. J. Tags: Original research Source Type: research

Safety and feasibility of treatment simplification to atazanavir/ritonavir + lamivudine in HIV-infected patients on stable treatment with two nucleos(t)ide reverse transcriptase inhibitors + atazanavir/ritonavir with virological suppression (Atazanavir and Lamivudine for treatment Simplification, AtLaS pilot study)
Conclusions Simplification to atazanavir/ritonavir + lamivudine was apparently safe and associated with rare virological failure, without resistance selection. This strategy deserves further investigation in a randomized trial. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Di Giambenedetto, S., Fabbiani, M., Colafigli, M., Ciccarelli, N., Farina, S., Sidella, L., D'Avino, A., Mondi, A., Cingolani, A., Tamburrini, E., Murri, R., Navarra, P., Cauda, R., De Luca, A. Tags: Original research Source Type: research

Switching to lopinavir/ritonavir with or without abacavir/lamivudine in lipoatrophic patients treated with zidovudine/abacavir/lamivudine
Conclusions In lipoatrophic patients treated with zidovudine/lamivudine/abacavir, switching to lopinavir/ritonavir monotherapy had no additional benefit in limb fat recovery relative to switching to lopinavir/ritonavir with abacavir/lamivudine. These data suggest that non-thymidine nucleosides such as abacavir/lamivudine are not an obstacle to limb fat recovery. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Bernardino, J. I., Pulido, F., Martinez, E., Arrizabalaga, J., Domingo, P., Portilla, J., Ocampo, A., Munoz, J., Torres, R., Arribas, J. R., on behalf of the GESIDA-6008-KRETA Study Group Tags: Original research Source Type: research

Switching the third drug of antiretroviral therapy to maraviroc in aviraemic subjects: a pilot, prospective, randomized clinical trial
Conclusions In this pilot, prospective, randomized clinical trial, switching the third drug to maraviroc was safe, efficacious and improved lipid parameters. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Bonjoch, A., Pou, C., Perez-Alvarez, N., Bellido, R., Casadella, M., Puig, J., Noguera-Julian, M., Clotet, B., Negredo, E., Paredes, R. Tags: Original research Source Type: research

Computational models can predict response to HIV therapy without a genotype and may reduce treatment failure in different resource-limited settings
Conclusions We developed computational models that predict virological response to ART without a genotype with comparable accuracy to genotyping with rule-based interpretation. These models have the potential to help optimize antiretroviral therapy for patients in RLSs where genotyping is not generally available. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - May 14, 2013 Category: Microbiology Authors: Revell, A. D., Wang, D., Wood, R., Morrow, C., Tempelman, H., Hamers, R. L., Alvarez-Uria, G., Streinu-Cercel, A., Ene, L., Wensing, A. M. J., DeWolf, F., Nelson, M., Montaner, J. S., Lane, H. C., Larder, B. A., on behalf of the RDI study group Tags: Original research Source Type: research

Human monoclonal ScFv that bind to different functional domains of M2 and inhibit H5N1 influenza virus replication
Human monoclonal single chain antibodies specific to the M2 protein of H5N1 influenza virus were produced and shown to inhibit viral replication, providing a possible treatment for infection. (Source: Virology Journal)
Source: Virology Journal - May 14, 2013 Category: Virology Authors: Tippawan PissawongSanti ManeewatchKanyarat Thueng-inPotjanee SrimanoteFonthip Dong-din-onJeeraphong ThanongsaksrikulThaweesak SongsermPongsri TongtaweKunan BangphoomiWanpen Chaicumpa Source Type: research

SF2/ASF binding region within JC virus NCCR limits early gene transcription in glial cells
Conclusions: The results of this study reveal a differential role of CR3 region within JCV NCCR in expression of JCV early and late genes. (Source: Virology Journal)
Source: Virology Journal - May 14, 2013 Category: Virology Authors: Elena UleriPatrick ReganAntonina DoleiIlker Sariyer Source Type: research

Growth characteristics of human parechovirus 1 to 6 on different cell lines and cross- neutralization of human parechovirus antibodies: a comparison of the cytopathic effect and real time PCR
Conclusion: When replication is monitored by PCR, growth of HPeV genotypes 1 to 6 is supported by most of the cell lines tested, where viral replication is measured before appearance of CPE. A combination of HT29 and Vero cells would therefore support replication of all culturable HPeV types, so viral replication could be detected by PCR within 3 days for all genotypes.In addition, we showed efficient neutralization for HPeV1, 2, 4, 5, while cross- neutralization was shown between these types, indicating possible common neutralizing epitopes. For HPeV3 no efficient (cross-) neutralization was shown, indicating different ne...
Source: Virology Journal - May 13, 2013 Category: Virology Authors: Brenda WesterhuisSara JonkerSandhia MattaoKimberley BenschopKatja Wolthers Source Type: research

Drug‐resistance development differs between HIV‐1‐infected patients failing first‐line antiretroviral therapy containing nonnucleoside reverse transcriptase inhibitors with and without thymidine analogues
ConclusionsAt first‐line regimen failure, a lower prevalence of RTI resistance was found in patients treated with NNRTI + non‐TA compared with those treated with NNRTI + zidovudine + lamivudine. These results confirm that the choice of backbone may influence the prevalence of drug resistance at virological failure. (Source: HIV Medicine)
Source: HIV Medicine - May 13, 2013 Category: Infectious Diseases Authors: MM Santoro, C Sabin, F Forbici, L Bansi, D Dunn, E Fearnhill, E Boumis, E Nicastri, A Antinori, G Palamara, A Callegaro, D Francisci, A Zoncada, F Maggiolo, M Zazzi, CF Perno, F Ceccherini‐Silberstein, C Mussini Tags: Short Communication Source Type: research

Effects of southern rice black-streaked dwarf virus on the development and fecundity of its vector, Sogatella furcifera
Conclusions: Both SRBSDV-infection and feeding on infected rice plants affected vector performance. Although a longer nymphal period benefits viral acquisition and transmission by nymphs and might increase rice infection rate, in general, SRBSDV infection of the vectors and host plants was unfavorable to WBPH population expansion. (Source: Virology Journal)
Source: Virology Journal - May 12, 2013 Category: Virology Authors: Zhi TuBing LingDonglin XuMaoxin ZhangGuohui Zhou Source Type: research

TH1 cytokine response to HCV peptides in Egyptian health care workers: a pilot study
In conclusion the magnitude and type of cytokines produced in HCV infection is critical in determining the outcome of infection. NS4 & NS5 HCV peptides induce a protective TH1 response in positive PI HCW (Source: Virology Journal)
Source: Virology Journal - May 11, 2013 Category: Virology Authors: Mona RafikAlaa MS HosnyKhaled AbdallahAmal AbbasRania Abo ShadyDina SolimanKhaled Nasr El-Din RakhaShahira Alfedawy Source Type: research

Mosquito Survey Identifies Reservoir Of Disease
A large scale, five year study of mosquitoes from different ecological regions in Kenya, including savannah grassland, semi-arid Acacia thorn bushes, and mangrove swamps, found a reservoir of viruses carried by mosquitoes (arboviruses) that are responsible for human and animal diseases. This research, published in BioMed Central's open access journal Virology Journal, highlights the need for continued surveillance in order to monitor the risk of disease outbreaks... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 10, 2013 Category: Consumer Health News Tags: Tropical Diseases Source Type: news

A comparison of efficacy and safety of 2‐year telbivudine and entecavir treatment in patients with chronic hepatitis B: a match–control study
Abstract There are limited data comparing the clinical outcomes between telbivudine and entecavir. We consecutively enrolled 115 telbivudine‐naive and 115 entecavir‐naive chronic hepatitis B patients, who were matched for age, sex, hepatitis B e antigen (HBeAg) status and cirrhosis, and treated for at least 2 years or less than 2 years but had developed resistance. Except for the rate of HBeAg seroconversion, which was similar, patients in the entecavir group had better clinical outcomes than those in the telbivudine group for alanine aminotransferase normalization (85.2% vs 78.4%, p <0.048), undetectable HBV DNA...
Source: Clinical Microbiology and Infection - May 10, 2013 Category: Microbiology Authors: M.‐C. Tsai, C.‐H. Chen, C.‐H. Hung, C.‐M. Lee, K.‐W. Chiu, J.‐H. Wang, S.‐N. Lu, P.‐L. Tseng, K.‐C. Chang, Y.‐H. Yen, T.‐H. Hu Tags: Original Article Source Type: research

Mosquito-borne arbovirus surveillance at selected sites in diverse ecological zones of Kenya; 2007 -- 2012
This survey of almost half a million mosquitoes over 5 years in Kenya identified 83 different viruses including alphavirus, flavivirus and orthobunyavirus species that cause human and animal disease, adding greatly to our understanding of arbovirus ecology in this region. (Source: Virology Journal)
Source: Virology Journal - May 10, 2013 Category: Virology Authors: Caroline OchiengJoel LutomiahAlbina MakioHellen KokaEdith ChepkorirSantos YalwalaJames MutisyaLillian MusilaSamoel KhamadiJason RichardsonJoshua BastDavid SchnabelEyako WurapaRosemary Sang Source Type: research

Maintenance of Th1 HCV‐specific responses in individuals with acute HCV who achieve sustained virological clearance after treatment
ConclusionTreatment‐induced viral clearance of recent HCV infection is associated with maintenance of HCV‐specific Th1 responses. (Source: Journal of Gastroenterology and Hepatology)
Source: Journal of Gastroenterology and Hepatology - May 10, 2013 Category: Gastroenterology Authors: Jacqueline K Flynn, Gregory J Dore, Margaret Hellard, Barbara Yeung, William D Rawlinson, Peter A White, John M Kaldor, Andrew R Lloyd, Rosemary A Ffrench, Tags: Experimental Hepatology Source Type: research

Considerations on the New Nevirapine: Switching Patients from Twice-Daily to Once-Daily
Nevirapine (NVP) was the first nonnucleoside reverse transcriptase inhibitor (NNRTI) approved for the treatment of HIV infection. NVP can provide safe and efficacious viral suppression for treatment-naive patients and for virologically controlled patients "switching" from other NNRTI or protease inhibitor–based regimens. Formulations allowing once-daily dosing of antiretrovirals can significantly improve regimen adherence, which is important for maintaining virologic control, especially for NNRTI-based regimens with low barriers for genetic resistance. Randomized and controlled clinical trials have established the cl...
Source: Journal of the International Association of Physicians in AIDS Care (JIAPAC) - May 10, 2013 Category: Infectious Diseases Authors: Ward, D., Slim, J. Tags: Short Communications Source Type: research