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Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Placental growth hormone (PGH) is synthesised by the placenta, and its function is modulated by growth hormone binding protein (GHBP). The potential of PGH and GHBP as maternal serum screening markers for Down syndrome (DS) was examined.Maternal serum concentrations of PGH and GHBP were determined by ELISA in 74 DS and 261 control pregnancies in gestational week 8+0 to 13+4. Log10 MoM distributions of the markers were established. The performance of DS screening was estimated by Monte Carlo simulation.PGH log10 MoM (SD) was decreased (p < 0.001) to -0.201 (0.373) and GHBP log10 MoM to -0.116 (0.265) (p = 0.04), in DS pregn...
Source: Prenatal Diagnosis - October 21, 2009 Authors: Michael Christiansen

Predicting VBAC Success: From Theory to Clinical PracticeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amer J Perinatol 2009; 26: 691-692DOI: 10.1055/s-0029-1241060© Thieme Medical PublishersGet connected:Table of contents | Full text
Source: American Journal of Perinatology - October 20, 2009 Tags: EDITORIAL

Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lundberg F, Cnattingius S, D'Onofrio B, Altman D, Lambe M, Hultman C, Iliadou A. Maternal smoking during pregnancy and intellectual performance in young adult Swedish male offspring. Paediatric and Perinatal Epidemiology 2009. Smoking during pregnancy has been linked to an increased risk of several adverse birth outcomes. Associations with deficits in cognitive development have also been suggested. It is unclear whether these associations are due to genetic and/or environmental confounding. In a population-based Swedish cohort study on 205 777 singleton males born to Nordic mothers between 1983 and 1988, we examined the as...
Source: Paediatric and Perinatal Epidemiology - October 20, 2009 Authors: Frida Lundberg, Sven Cnattingius, Brian D'Onofrio, Daniel Altman, Mats Lambe, Christina Hultman, Anastasia Iliadou

Maternal serum screening marker levels in women with a previous aneuploidy pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To re-evaluate in a larger cohort of patients if the maternal serum biochemical markers used in first trimester aneuploidy screening have the same marker distributions in pregnancies with a previous history of aneuploidy compared with those that have no previous history.Information related to previous pregnancy history is routinely recorded as part of first trimester screening in three centres King George, Kings College and Fetal Medicine Centre, London. From the database, records were extracted for women who had a previous pregnancy diagnosed with trisomies 13, 18 or 21. For each woman with a previous aneuploidy, five una...
Source: Prenatal Diagnosis - October 20, 2009 Authors: Kevin Spencer, Ismini Staboulidou, Jader De Jesus Cruz, George Karagiannis, Kypros H. Nicolaides

Noninvasive prenatal diagnosis of early onset primary dystonia I in maternal plasmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The genetic trait of a fetus may be determined early on in pregnancy using cell-free fetal DNA extracted from the plasma of pregnant women. The challenges for noninvasive diagnosis include the variable but still low amount of cell-free fetal DNA in the first trimester (57-761 gE/mL) and the competing high background of maternal DNA in the plasma ([sim]90%). Prenatal detection of a paternally inherited dystonia 3 bp deletion mutation was undertaken using cell-free DNA (cfDNA) from the plasma of two at-risk pregnancies. The predicted fetal genotype was subsequently confirmed in each fetus.Cell-free fetal DNA was extracted fr...
Source: Prenatal Diagnosis - October 20, 2009 Authors: Cathy Meaney, G. Norbury

Placental protein 13 as a first trimester screening marker for aneuploidyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To determine whether Placental Protein 13 (PP13) could be an additional marker in first trimester screening for aneuploidies.To evaluate differences in multiples of the gestation-specific normal median (MoMs), PP13 concentrations were measured in serum samples from Down syndrome, trisomy 18 and 13 affected pregnancies and euploid singleton pregnancies (four for each case matched for duration of storage, maternal weight and age).The PP13 MoM in Down syndrome cases (n = 153) was 0.91 [not statistically significant from controls (n = 853); P = 0.06; Wilcoxon rank sum test, two-tail]. PP13 MoMs were decreased in trisomy 18 (n ...
Source: Prenatal Diagnosis - October 20, 2009 Authors: M. P. H. Koster, E. J. Wortelboer, H. S. Cuckle, Ph. Stoutenbeek, G. H. A. Visser, P. C. J. I. Schielen

Reproducibility of reported nutrient intake and supplement use during a past pregnancy: a report from the Children's Oncology GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bosco JLF, Tseng M, Spector LG, Olshan AF, Bunin GR. Reproducibility of reported nutrient intake and supplement use during a past pregnancy: a report from the Children's Oncology Group. Paediatric and Perinatal Epidemiology 2009. Maternal diet and nutrition have been thought to play a role in many childhood conditions. Studies using food frequency questionnaires (FFQ) have reported associations with maternal diet, but these findings are difficult to interpret because the reliability and validity of the FFQs for diet during a past pregnancy are not known. We determined the reproducibility of reported diet and supplement use...
Source: Paediatric and Perinatal Epidemiology - October 19, 2009 Authors: Jaclyn L. F. Bosco, Marilyn Tseng, Logan G. Spector, Andrew F. Olshan, Greta R. Bunin

Inverse shifting PCR based prenatal diagnosis of hemophilia-causative inversions involving int22h and int1h hotspots from chorionic villus samplesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract.
Source: Prenatal Diagnosis - October 19, 2009 Authors: Claudia P. Radic, Liliana C. Rossetti, Johanna R. Zuccoli, Martín M. Abelleyro, Irene B. Larripa, Carlos D. De Brasi

Ethnic differences in considerations whether or not to participate in prenatal screening for Down syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To evaluate ethnic differences in considerations whether or not to participate in prenatal screening for Down syndrome and to relate these to differences in participation.The study population consisted of 270 pregnant women from Dutch, Turkish and Surinamese (African and South Asian) ethnic origin, attending midwifery or obstetrical practices in the Netherlands. Women were interviewed after booking for prenatal care. Considerations were assessed by one open-ended question and 18 statements that were derived from focus group interviews. Actual participation was assessed several months later.Women from ethnic minorities were...
Source: Prenatal Diagnosis - October 19, 2009 Authors: Mirjam P. Fransen, Hajo I. J. Wildschut, Ineke Vogel, Johan P. Mackenbach, Eric A. P. Steegers, Marie-Louise Essink-Bot

Amplification failure of the amelogenin gene (AMELX) caused by a primer binding site mutationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract.
Source: Prenatal Diagnosis - October 19, 2009 Authors: S. Caratti, G. Voglino, V. Cirigliano, A. Ghidini, R. Taulli, C. Torre, Carlo Robino

Early onset preeclampsia and second trimester serum markersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To examine serum markers measured in the second trimester to identify women who subsequently develop preeclampsia.Clinically defined preeclampsia was confirmed in 45 women who had provided a serum sample as part of Down syndrome screening. Preeclampsia was categorized as mild or severe, as well as early (
Source: Prenatal Diagnosis - October 19, 2009 Authors: Geralyn M. Lambert-Messerlian, Glenn E. Palomaki, Louis M. Neveux, Edward Chien, Alex Friedman, Karen Rosene-Montella, Meghan Hayes, Jacob A. Canick

Website ReviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 229-229.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

FarewellEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 231-231.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

ABM Clinical Protocol #21: Guidelines for Breastfeeding and the Drug-Dependent WomanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 225-228.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

Victories and ChallengesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 187-188.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

Abstract Author IndexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 247-248.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

The Academy of Breastfeeding Medicine 14th Annual International Meeting; Lessons from History, Implications for Tomorrow; Williamsburg, Virginia; November 5–8, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Dec 2009, Vol. 4, No. 4: 233-246.
Source: Breastfeeding Medicine - October 16, 2009 Tags: article

Maternal Serum Screening: Results Disclosure, Anxiety, and Risk PerceptionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amer J PerinatolDOI: 10.1055/s-0029-1241730ABSTRACTAlthough increased maternal anxiety following the disclosure of positive second-trimester maternal serum screen (MSS) results has been well documented, how this anxiety correlates with the method of results disclosure has not been well defined. This pilot study aimed to determine how abnormal second-trimester MSS results are disclosed, the level of anxiety experienced by women as a result of this disclosure, and the accuracy of their risk perception. Women referred for prenatal genetic counseling were asked to complete a questionnaire including demographics, standardized S...
Source: American Journal of Perinatology - October 16, 2009

Asymptomatic Bacteriuria in Pregestational Diabetic Pregnancies and the Role of Group B StreptococcusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amer J PerinatolDOI: 10.1055/s-0029-1239485ABSTRACTWe sought to determine if gravidas with pregestational diabetes mellitus (DM) are at increased risk for asymptomatic bacteriuria (ASB) compared with nondiabetic gravidas. This is a retrospective case-control study of 150 pregnant patients with pregestational DM and 294 nondiabetic controls. Rates of ASB and any colony count of group B streptococcus (GBS) bacteriuria were reviewed. The incidence of ASB among pregestational diabetics was higher compared with nondiabetic gravidas (18% versus 8.2%, odds ratio [OR] 2.47, 95% confidence interval [CI] 1.37 to 4.45). GBS was the m...
Source: American Journal of Perinatology - October 16, 2009

The risk factors for unexplained antepartum stillbirths in Scotland, 1994 to 2003Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& W C S Smith
Source: Journal of Perinatology - October 15, 2009 Authors: R SutanD CampbellG J PrescottW C S Smith

Fluctuations in anti-factor Xa levels with therapeutic enoxaparin anticoagulation in pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& A B Hameed
Source: Journal of Perinatology - October 15, 2009 Authors: E FriedrichA B Hameed

Methods for developing useful estimates of the costs associated with birth defectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cost estimates for birth defects are useful to policy makers in deciding the best use of resources to prevent these conditions. Much of the effort in this area has focused on spina bifida, in part because cost savings can be estimated from folic acid-preventable cases. However, comprehensive cost-of-illness estimates for this condition may be too outdated, too general, or not applicable to individual states' environments.Using the live birth prevalence for spina bifida in Texas, we applied recent spina bifida cost estimates to approximate total lifetime medical and other costs for an average live birth cohort of spina bifi...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 15, 2009 Authors: Amy P. Case, Mark A. Canfield

Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The CNS-active VPA analogs containing a urea moiety, which have better anticonvulsant potency and lack teratogenicity, are good potential candidates as second-generation VPA antiepileptic drugs. Birth Defects Res (Part B) xx:1-8, 2009. © 2009 Wiley-Liss, Inc.
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - October 15, 2009 Authors: Akinobu Okada, Hiroko Noyori, Boris Yagen, Jakob Avi Shimshoni, Meir Bialer, Michio Fujiwara

Workgroup Summary: Healthcare SystemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-79-S-80.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

First Annual Summit on Breastfeeding ParticipantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-83-S-86.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Workgroup Summary: Support ServicesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-81-S-81.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Workgroup Summary: Professional EducationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-77-S-78.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Remarks of the Rev. Douglas A. GreenawayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-55-S-56.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Effectively Communicating Your Case: Increasing Support for BreastfeedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-51-S-53.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Workgroup Summary: World of WorkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-73-S-74.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Workgroup Summary: Public EducationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-75-S-76.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Opening Keynote Remarks to the First Breastfeeding SummitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-5-S-7.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Health, Science, and the MediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-71-S-72.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Growth of Breastfed InfantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-45-S-49.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Breastfeeding and Health OutcomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-13-S-15.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Progress in Protecting, Promoting, and Supporting Breastfeeding: 1984–2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-31-S-39.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Promoting Health Literacy and Health BehaviorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-67-S-67.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Promoting Breastfeeding in the Hispanic CommunityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-69-S-70.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Renewing a Commitment and Leading the ChargeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-1-S-2.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Opening Address: Former Surgeon General, C. Everett Koop, MD, ScDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-3-S-3.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

A Summary of the Agency for Healthcare Research and Quality's Evidence Report on Breastfeeding in Developed CountriesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-17-S-30.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

First Food: The Essential Role of BreastfeedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-9-S-10.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Increasing Breastfeeding: Challenges and OpportunitiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-63-S-65.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Academy of Breastfeeding Medicine President's GreetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-11-S-11.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Breastfeeding and the WIC ProgramEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-57-S-58.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Inadequate: A Metaphor for the Lives of Low-Income Women?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-41-S-43.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Establishing the Business Case for BreastfeedingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Breastfeeding Medicine Oct 2009, Vol. 4, No. s1: S-59-S-62.
Source: Breastfeeding Medicine - October 14, 2009 Tags: article

Hospital use and associated costs of children aged zero-to-two years with craniofacial malformations in MassachusettsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Craniofacial malformations (CFMs) are among the most common and correctable birth defects in the United States, often requiring multiple medical and surgical treatments. However, population-based data on hospital utilization and costs are sparse.This retrospective cohort study used linked data from the Massachusetts Pregnancy to Early Life Longitudinal Data System. Cases were children born during 1998-2002 in Massachusetts hospitals to Massachusetts residents, alive at age two years, and ascertained by the Massachusetts Birth Defects Monitoring Program as having a CFM (orofacial cleft, craniosynostosis, microtia/anotia). M...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - October 14, 2009 Authors: Judith Weiss, Milton Kotelchuck, Scott D. Grosse, Susan E. Manning, Marlene Anderka, Diego F. Wyszynski, Howard Cabral, Wanda Barfield, Raul Garcia, Emily Lu, Cathy Higgins

An Examination of the Clinical Benefits and Cost-Effectiveness of Tocolytic Replacement Following Recurrent Preterm LaborEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined pregnancy outcomes in women receiving nifedipine tocolysis having recurrent preterm labor (RPTL). Singleton gestations enrolled for outpatient nursing surveillance and prescribed nifedipine tocolysis were identified ( = 4748). Women hospitalized for RPTL at <35 weeks then resuming outpatient surveillance were included ( = 1366). Pregnancy outcomes of women resuming nifedipine ( = 830) were compared with those having an alteration in treatment to continuous subcutaneous terbutaline ( = 536). Overall, 56.7% (2692/4748) experienced RPTL. Half (50.7%) were stabiliz...
Source: American Journal of Perinatology - October 13, 2009

Anterior Fontanel Size in Term and Late Preterm Hispanic Neonates: Description of Normative Values and an Alternative Measurement MethodEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides normative data for AFS using two methods in Hispanic neonates. A modest trend toward less variability with the DIAG method was noted. Male gender and longer duration of labor were associated with larger AFS.[...]© Thieme Medical PublishersGet connected:Table of contents | Abstract | Full text
Source: American Journal of Perinatology - October 13, 2009