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An update on transforming growth factor‐β (TGF‐β): Sources, types, functions and clinical applicability for cartilage/bone healingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractTransforming growth factor‐β (TGF‐β) has been reviewed for its sources, types of isoforms, biochemical effects on cartilage formation/repair, and its possible clinical applications. Purification of three isoforms (TGF‐β‐1, β‐2 and β‐3) and their biochemical characterization revealed mainly their homo‐dimer nature, with heterodimers in traces, each monomer comprised of 112 amino acids and MW. of 12 500 Da. While histo‐chemical staining by a variety of dyes has revealed precise localization of TGF‐β in tissues, immune‐blot technique has thrown light on their expression as a function of a...
Source: Journal of Cellular Physiology - September 23, 2011 Category: Cytology Authors: A. S. PatilR. B. SableR. M. Kothari Tags: Mini‐Review Source Type: research

National Association of Neonatal Nurses (NANN) 27th Annual Educational ConferenceNational Association of Neonatal Nurses (NANN) 27th Annual Educational Conferenceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Read clinically focused news coverage of key developments from the meeting. Medscape Nurses
Source: Medscape Today Headlines - September 23, 2011 Category: Consumer Health News Tags: Conference Coverage Source Type: news

Early end‐tidal carbon monoxide levels and neurodevelopmental outcome at 3 years 6 months of age in preterm infantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study comprised 105 very preterm infants (57 males, 48 females; gestational age range 25wks 5d–31wks 4d; birthweight 610–2100g) who were admitted to a neonatal intensive care unit between 1 February and 31 December 2002. ETCOc, plasma tumour necrosis factor alpha (TNF‐α) and interleukins (IL) 6 and 8, and malondialdehyde (MDA, a marker of lipid peroxidation), were measured at days 1, 3, and 5 of life and related to outcome at 3 years 6 months of age (Griffiths Mental Developmental Scales).Results  Of the 105 infants, 69 were eligible for follow‐up (37 males; 32 females; bronchopulmonary dysplasia, n=12)...
Source: Developmental Medicine and Child Neurology - September 23, 2011 Category: Child Development Authors: CORNELIE A BLOKTANNETTE G KREDIETANNEMIEK KAVELAARSCORINE KOOPMAN‐ESSEBOOMHENDRIK J VREMANFRANK VAN BEL Tags: ORIGINAL ARTICLE Source Type: research

Health-related quality of life, emotional and behavioral problems in mild to moderate prematures at (pre-)school ageemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: Children born at 32 to 36weeks' gestational age do not experience an overall lower HR-QoL at 2 to 5years of age. CPAP results in lower HRQoL scores for lung problems. The overall occurrence of behavioral and emotional problems does not differ from the general term-born pediatric population. Several subitems need further attention.
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Naomi Ketharanathan, Weiling Lee, Amerik C. de Mol Source Type: research

QEEG norms for the first year of lifeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: These qEEG norms are highly useful as an aid to visual interpretation and for the study of pathology further evolution as well as for assessment of infants showing brain risk factors. To our knowledge this is the first normative qEEG study for the initial year of life with such large sample and validation-group.
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: G.A. Otero, T. Harmony, F.B. Pliego-Rivero, J. Ricardo-Garcell, J. Bosch-Bayard, R. Porcayo-Mercado, A. Fernández-Bouzas, L. Díaz-Comas, L. Galán, P. Vieyra-Reyes, T. Fernández Source Type: research

Mediators involved in retinopathy of prematurity and emerging therapeutic targetsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article reviews new information available on the molecular pathogenesis of ROP which may result in novel treatments for ROP; it does not discuss the well-known role of oxygen in the development of ROP.
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: A. Mataftsi, S.A. Dimitrakos, G.G.W. Adams Source Type: research

Laboratory markers of perinatal acidosis are poor predictors of neurodevelopmental impairment in very low birth weight infantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Background: In asphyxiated term and near-term infants, therapeutic hypothermia increases survival without neurologic morbidity, and extending this new treatment to preterm infants is being debated.Aims: To investigate the association of low pH and base excess (BE) at birth or admission, as used as entry criteria in cooling trials, and evolving brain damage in preterm infants.Study design and measurements: Rates of death and neurodevelopmental impairment at 12 and 20months corrected age were assessed in a cohort of 1137 preterm infants with a gestational age
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Dieter Hüseman, Boris Metze, Elisabeth Walch, Christoph Bührer Source Type: research

Ages and stages questionnaires: Feasibility of postal surveys for child follow-upemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Use of the French ASQ in a research cohort appears feasible as response rates were high. Moreover, known links between child development measured by ASQ and birth and social characteristics were observed. However, further French studies are needed to understand differences observed in 12-month ASQ gross motor scores compared with US norms. For research purposes, further analysis of the ASQ in innovative, quantitative approaches, is needed.
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Pénélope Troude, Jane Squires, Laurence Foix L'Hélias, Jean Bouyer, Elise de La Rochebrochard Source Type: research

Low ponderal index is associated with decreased muscle strength and fatigue resistance in college-aged womenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Poor fetal growth is associated with decrements in muscle strength likely due to changes during myogenesis. We investigated the association of poor fetal growth with muscle strength, fatigue resistance, and the response to training in the isolated quadriceps femoris. Females (20.6years) born to term but below the 10th percentile of ponderal index (PI)-for-gestational-age (LOWPI, n=14) were compared to controls (HIGHPI, n=14), before and after an 8-week training. Muscle strength was assessed as grip-strength and as the maximal isometric voluntary contraction (MVC) of the quadriceps femoris. Muscle fatigue was asse...
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Tom D. Brutsaert, Kelli H. Tamvada, Melisa Kiyamu, Daniel D. White, Timothy B. Gage Source Type: research

Serum intestinal fatty acid binding protein level for early diagnosis and prediction of severity of necrotizing enterocolitisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, we aimed to investigate the value of serum I-FABP in early diagnosis and predicting severity of NEC.Methods: This prospective study was conducted between April 2009 and November 2009. The preterm infants with suspected NEC were included in the study. These infants were divided into two groups according to their final diagnoses; Group 1: Stage 1 NEC and Group 2: Stages 2–3 NEC (Group 2a: Stage 2 NEC, Group 2b: Stage 3 NEC). Healthy preterms were assigned to control group (Group 3). Serial blood samples were obtained from the patients at symptom onset, 24h and 72h later. One blood sample was taken from the c...
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Cumhur Aydemir, Dilek Dilli, Serife Suna Oguz, Hulya Ozkan Ulu, Nurdan Uras, Omer Erdeve, Ugur Dilmen Source Type: research

Low gestational age and chronic lung disease are synergistic risk factors for retinopathy of prematurityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Aims: This retrospective, population based study was designed to investigate risk factors for development of retinopathy of prematurity (ROP) and their possible interrelationships, in neonates of gestational age (GA) grade 2: 6). Logistic regression analysis showed ROP to be strongly associated with GA, odds ratio (OR) 2.1, confidence interval (CI) 1.3–3.3, p
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Vasileios Giapros, Aikaterini Drougia, Ioannis Asproudis, Paraskevi Theocharis, Styliani Andronikou Source Type: research

Predictors of growth velocity in early infancy in a resource-poor settingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract: Objective: To determine the pattern and predictors of growth velocity in early infancy in a resource-poor setting.Methods: Weight velocity between birth and first postnatal visit was determined in a cohort of preterm and full-term infants in Lagos, Nigeria using three mathematical methods reported in the literature. Maternal and infant factors predictive of weight velocity were identified by multiple linear regression analysis.Results: Overall, 658 infants were enrolled with mean gestational age of 37.7±2.0weeks, birthweight of 3.2±0.6kg and median age of 45 (interquartile range: 42–48) days at follow-up. Off...
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Authors: Bolajoko O. Olusanya, James K. Renner Source Type: research

Editorial Boardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Early Human Development - September 23, 2011 Category: Perinatology & Neonatology Source Type: research

Intracranial Ultrasound Abnormalities and Fetal Cytomegalovirus Infection: Report of 8 Cases and Review of the Literatureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Fetal Diagn Ther 2011;30:141–149 (DOI:10.1159/000330636)
Source: Fetal Diagnosis and Therapy - September 23, 2011 Category: Perinatology & Neonatology Source Type: research

Phenotypic Variability in Fetuses with Down Syndrome: A Case-Control Pathological Evaluationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000329309)
Source: Fetal Diagnosis and Therapy - September 22, 2011 Category: Perinatology & Neonatology Source Type: research

First-Trimester Screening for Trisomy 21 Using Alpha-Fetoproteinemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Fetal Diagn Ther (DOI:10.1159/000330198)
Source: Fetal Diagnosis and Therapy - September 22, 2011 Category: Perinatology & Neonatology Source Type: research

Increased uterine artery pulsatility index at 34 weeks and outcome of pregnancyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ConclusionIncreased UtA‐PI as an isolated finding at 34 weeks' gestation is associated with an increased risk of delivering an SGA neonate. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Source: Ultrasound in Obstetrics and Gynecology - September 22, 2011 Category: Radiology Authors: E. MaroniA. YoussefT. ArcangeliM. NanniF. De MussoE. ControM. KulevaF. BellussiG. PiluN. RizzoT. Ghi Tags: Original Paper Source Type: research

Current Challenges in Pediatric Nutritionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In pediatric nutrition the most important overall theme is breastfeeding. While there is no alternative in most mammals—and offspring would die if the mother had no milk or could not feed the newborn—human mothers were offered alternative ways of infant feeding. Today restoring breastfeeding is a major goal for pediatricians, midwifes, and lactation advisers.Feeding the premature baby and adding long chain fatty acids and prebiotics to formula is an area of growing interest. Undernutrition is a special challenge for nutritional care because even in recent years severely undernourished children die of inadequate managem...
Source: Current Problems in Pediatric and Adolescent Health Care - September 22, 2011 Category: Pediatrics Authors: Michael B. Krawinkel Source Type: research

Introductionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
As nutrition is an often neglected aspect of pediatric care, it is much welcomed that the editors of this series decided to dedicate 1 issue to nutrition in pediatrics. Focusing on nutrition by contrast means opening a wide field, from infant and child feeding, over feeding the premature baby until the various aspects of “clinical nutrition,” being it artificial feeding, including enteral and parenteral, or feeding the child with special needs, eg, metabolic disorders (eg, phenylketonuria), behavioral problems (eg, anorexia nervosa), food allergy and celiac disease, other forms of chronic diarrhea, inflammatory bowel d...
Source: Current Problems in Pediatric and Adolescent Health Care - September 22, 2011 Category: Pediatrics Authors: Michael B. Krawinkel Source Type: research

Congenital Syphilis Like Many Years Agoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This case concerns a premature infant with typical signs of congenital syphilis born to an untreated foreign mother. Syphilis prevalence in pregnant women has been rising in Italy since the beginning of the 21st century, mainly due to immigration. A correct antenatal syphilis screening and consequent adequate therapy of pregnant woman are fundamental to prevent the neonatal infection.
Source: Infectious Diseases in Obstetrics and Gynecology - September 22, 2011 Category: OBGYN Source Type: research

Surprising uptick in mortality for premature babies when they grow upemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
It’s been shown previously that infants born prematurely suffer an increased risk of adverse health effects, but does this effect continue into adulthood?
Source: Health Facts and Fears - September 22, 2011 Category: Consumer Health Advice Tags: Blogs Source Type: news

Beta2‐agonists use during pregnancy and the risk of congenital malformationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONOur study supports the evidence of SABA safety during pregnancy, but more research is required to assess whether the increased risk of malformations among LABA users is due to the medication, bias by asthma severity, or chance alone. Birth Defects Research (Part A) 2011. © 2011 Wiley‐Liss, Inc.
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 22, 2011 Category: Perinatology & Neonatology Authors: Sherif EltonsyAmélie ForgetLucie Blais Tags: Original Article Source Type: research

Knowledge transfer and translation: Examining how teratogen information is disseminatedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONIt is evident that KT in this area needs improvement. Women and their health care providers are highly impacted by the type of teratology information they receive, affecting for example, deciding to terminate a wanted pregnancy or discontinue a needed pharmacotherapy. When disseminating information in this very sensitive and complex field, it is imperative that good KT strategies are used, encompassing the availability and appropriate interpretation of information. It is most important that an evidence‐based decision is made to ensure the optimal outcome for both the mother and her unborn child Birth Defects Re...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 22, 2011 Category: Perinatology & Neonatology Authors: Ilan ShahinAdrienne Einarson Tags: Original Article Source Type: research

Maternal occupational pesticide exposure and risk of hypospadias in the national birth defects prevention studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSIONUsing broad classes of insecticides, herbicides, and fungicides, we found no evidence that low intensity maternal periconceptional occupational pesticide exposure was a risk factor for hypospadias. Birth Defects Research (Part A) 2011. © 2011 Wiley‐Liss, Inc.
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - September 22, 2011 Category: Perinatology & Neonatology Authors: Carissa M. RocheleauPaul A. RomittiWayne T. SandersonLixian SunChristina C. LawsonMartha A. WatersPatricia A. StewartRichard S. OlneyJennita Reefhuis Tags: Original Article Source Type: research

Renin is activated in monochorionic diamniotic twins with birthweight discordance who do not have twin-to-twin transfusion syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
a, H Yamada & M Matsuo
Source: Journal of Perinatology - September 22, 2011 Category: Perinatology & Neonatology Authors: K FujiokaI MoriokaA MiwaT YokotaK MatsuoS MorikawaM EnomotoA ShibataM MorizaneN YokoyamaH YamadaM Matsuo Tags: twin pair discordancy umbilical cord blood renin–angiotensin–aldosterone system natriuretic peptide system Source Type: research

Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange: any benefits?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange: any benefits? Journal of Perinatology advance online publication, September 22, 2011. doi:10.1038/jp.2011.131 Authors: M Nyp, T Sandritter, N Poppinga, C Simon & W E Truog
Source: Journal of Perinatology - September 22, 2011 Category: Perinatology & Neonatology Authors: M NypT SandritterN PoppingaC SimonW E Truog Tags: sildenafil BPD bronchopulmonary dysplasia pulmonary hypertension iNO Source Type: research

A randomized trial of the Vein Viewer versus standard technique for placement of peripherally inserted central catheters (PICCs) in neonatesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
& M Walsh
Source: Journal of Perinatology - September 22, 2011 Category: Perinatology & Neonatology Authors: K PhippsA ModicM A O'RiordanM Walsh Tags: vascular access vein visualization technology newborn successful venipuncture venous catheterization Source Type: research

Delivery room resuscitation of preterm infants in Canada: current practice and views of neonatologists at level III centersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
mp; P J McNamara
Source: Journal of Perinatology - September 22, 2011 Category: Perinatology & Neonatology Authors: W El-NaggarP J McNamara Tags: delivery room resuscitation preterm infants Source Type: research

Relationship between birth weight and retinal microvasculature in newborn infantsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
& L Hartley
Source: Journal of Perinatology - September 22, 2011 Category: Perinatology & Neonatology Authors: Y KandasamyR SmithI M R WrightL Hartley Tags: retinal arterioles retinal venules middle cerebral artery intrauterine growth restriction Source Type: research

The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTHemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
by Jingning Liu, Fangqiao Lv, Wen Sun, Chunxiang Tao, Guoxian Ding, Andrew Karaplis, Edward Brown, David Goltzman, Dengshun Miao Patients with neonatal severe hyperparathyroidism (NSHPT) are homozygous for the calcium-sensing receptor (CaR) mutation and have very high circulating PTH, abundant parathyroid hyperplasia, and severe life-threatening hypercalcemia. Mice with homozygous deletion of CaR mimic the syndrome of NSHPT. To determine effects of CaR deficiency on skeletal development and interactions between CaR and 1,25(OH)2D3 or PTH on calcium and skeletal homeostasis, we compared the skeletal phenotypes of homoz...
Source: PLoS Genetics - September 22, 2011 Category: Genetics & Stem Cells Authors: Jingning Liu et al. Source Type: research

Polymorphisms of the gamma crystallin A and B genes among Indian patients with pediatric cataractemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion : rs2289917 risk allele showed a strong association with increased vulnerability for pediatric cataract. The findings suggest that this association may be a secondary phenomenon related to genetic variation playing critical role in lens development during perinatal and/or pediatric growth. Present exploratory study provides a basis for further defining the role of PR as a regulator of CRYG locus in lens formation/transparency.
Source: Journal of Postgraduate Medicine - September 22, 2011 Category: Internal Medicine Authors: S MehraS KapurAR Vasavada Source Type: research

Knowledge, attitude and practice of pediatric critical care nurses towards pain: Survey in a developing country settingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions : There are several lacunae in the knowledge and practice of nurses in developing countries which need to be improved by training.
Source: Journal of Postgraduate Medicine - September 22, 2011 Category: Internal Medicine Authors: PJ MathewJL MathewS Singhi Source Type: research

Life-Threatening Hyponatremia and Acute Renal Failure due to Iatrogenic Neonatal Bladder Ruptureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Urol Int (DOI:10.1159/000331495)
Source: Urologia Internationalis : Last 20 articles - September 21, 2011 Category: Urology & Nephrology Source Type: research

Preemie Parents May Be Worried Sick by Testsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Preemie parents may be left with lingering anxiety when newborn screening tests sound a false alarm, possibly driving them to take their baby to the doctor more often, a new study hints.Source: Reuters Health Related MedlinePlus Pages: Newborn Screening, Premature Babies
Source: MedlinePlus Health News - September 21, 2011 Category: Consumer Health News Source Type: news

Preemies may face higher risk of death as young adultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Babies who are born premature have a higher risk of dying as young adults than those born full term, a surprising new study has found.
Source: CTV Health - September 21, 2011 Category: Consumer Health News Source Type: news

Targeted Neonatal Echocardiography in the Neonatal Intensive Care Unit: Practice Guidelines and Recommendations for Training: Writing group of the American Society of Echocardiography (ASE) in collaboration with the European Association of Echocardiography (EAE) and the Association for European Pediatric Cardiologists (AEPC)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Journal of the American Society of Echocardiography - September 21, 2011 Category: Cardiology Authors: Luc Mertens, Istvan Seri, Jan Marek, Romaine Arlettaz, Piers Barker, Patrick McNamara, Anita J. Moon-Grady, Patrick D. Coon, Shahab Noori, John Simpson, Wyman W. Lai Tags: Expert Consensus Statement Source Type: research

Preemies Face Higher Risk of Death in Early Adulthoodemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
It's not surprising that premature babies are less likely to survive compared to full-term infants, but what is groundbreaking news is that years after their birth, they stand a 38% increased risk of dying in young adulthood, according to research published Tuesday in the Journal of the American Medical Association.
Source: RWJF News Digest - Public Health - September 21, 2011 Category: American Health Source Type: news

Preterm Birth Linked To Higher Risk Of Death In Early Childhood Or Young Adulthoodemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
According to an investigation in the September 21 issue of JAMA, an investigation that consisted of over 600,000 infants born in Sweden between 1973 and 1976, revealed that those who were born prematurely (less that 37 weeks gestation) had an increased risk of death during early childhood and young adulthood in comparison to those born full term. In developed countries, premature birth is the leading cause of perinatal (pertaining to the period immediately before and after birth) illness and death...
Source: Health News from Medical News Today - September 21, 2011 Category: Consumer Health News Tags: Pregnancy / Obstetrics Source Type: news

Preemies may face higher death rates as adultsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Reuters) - Health problems are common among premature babies, who are more likely to die than their full-term peers during the first few years of life -- and they may also face slightly increased death rates as young adults, a study said.
Source: Reuters: Health - September 21, 2011 Category: Consumer Health News Tags: healthNews Source Type: news

Creatine affects in vitro electrophysiological maturation of neuroblasts and protects them from oxidative stressemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractCreatine (Cr) is a very popular ergogenic molecule that has recently been shown to have antioxidant properties. The effectiveness of Cr supplementation in treating neurological diseases and Cr deficiency syndromes has been demonstrated, and experimental reports suggest that it plays an important role in CNS development. In spite of this body of evidence, the role of Cr in functional and structural neuronal differentiation is still poorly understood. Here we used electrophysiological, morphological, and biochemical approaches to study the effects of Cr supplementation on in vitro differentiation of spinal neuroblast...
Source: Journal of Neuroscience Research - September 21, 2011 Category: Neuroscience Authors: Stefano SartiniPiero SestiliEvelin ColomboChiara MartinelliFanny BartoliniStefano CiuffoliDavide LattanziDavide SistiRiccardo Cuppini Tags: Research Article Source Type: research

Increased p38 mitogen‐activated protein kinase signaling is involved in the oxidative stress associated with oxygen and glucose deprivation in neonatal hippocampal slice culturesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractThe pathological basis of neonatal hypoxia–ischemia (HI) brain damage is characterized by neuronal cell loss. Oxidative stress is thought to be one of the main causes of HI‐induced neuronal cell death. The p38 mitogen‐activated protein kinase (MAPK) is activated under conditions of cell stress. However, its pathogenic role in regulating the oxidative stress associated with HI injury in the brain is not well understood. Thus, this study was conducted to examine the role of p38 MAPK signaling in neonatal HI brain injury using neonatal rat hippocampal slice cultures exposed to oxygen/glucose deprivation (OGD). O...
Source: European Journal of Neuroscience - September 21, 2011 Category: Neuroscience Authors: Qing LuThomas F. RauValerie HarrisMaribeth JohnsonDavid J. PoulsenStephen M. Black Source Type: research

Commentary on “Incidence and Nature of Testicular Toxicity Findings…”email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - September 21, 2011 Category: Perinatology & Neonatology Authors: Kim Boekelheide Tags: Editorial Source Type: research

Maternally inherited partial monosomy 9p (pter → p24.1) and partial trisomy 20p (pter → p12.1) characterized by microarray comparative genomic hybridizationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this report, we compare the phenotype of our patient with those already reported in the literature, and discuss the role of DMRT, DOCK8, FOXD4, VLDLR, RSPO4, AVP, RASSF2, PROKR2, BMP2, MKKS, and JAG1, all genes mapping to the deleted and duplicated regions. © 2011 Wiley Periodicals, Inc.
Source: American Journal of Medical Genetics Part A - September 21, 2011 Category: Genetics & Stem Cells Authors: Érika L. FreitasSusan M. GribbleMilena SimioniTársis P. VieiraRoseane L. Silva‐GreccoMarly A. S. BalarinElena PrigmoreAna C. Krepischi‐SantosCarla RosenbergKaroly SzuhaiArie van HaeringenNigel P. CarterVera Lúcia Gil‐da‐Silva‐Lopes Tags: Clinical Report Source Type: research

Stillbirth differences according to regions of origin: an analysis of the German perinatal database, 2004-2007email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: We found differences in risk of stillbirth among women from Middle East/North Africa, especially in association with low SES and low birthweight for gestational age. Our findings suggest a need for developing and evaluating socially and culturally sensitive health promotion and prevention programmes for this group. The findings should also stimulate discussion about the quality and appropriateness of antenatal and perinatal care of pregnant women and newborns with migrant backgrounds.Keywords stillbirth, region of origin, relative differences, risk factors
Source: BMC Pregnancy and Childbirth - Latest articles - September 21, 2011 Category: OBGYN Authors: Anna ReeskeMarcus KutschmannOliver RazumJacob Spallek Source Type: research

Travel time from home to hospital and adverse perinatal outcomes in women at term in The Netherlandsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study provides some evidence that increased travel time to hospital may increase the incidence of adverse perinatal outcomes for high-risk women at term. Increased risk of adverse outcomes associated with travel time to hospital when in labour should be taken into account when considering centralising maternity services. Future research should separate low- and high-risk women with analyses conducted separately for each group. Future research should include data about mode of delivery and factors affecting neonatal mortality and morbidity postbirth such as pathological jaundice, Group B streptococcus infections, pr...
Source: Evidence-Based Nursing - September 21, 2011 Category: Nursing Authors: Hall, W. A. Tags: Pain (neurology), Child health, Infant health, Neonatal health, Pain (palliative care), Pain (anaesthesia) Midwifery Source Type: research

c‐Jun is essential for the induction of Il‐1β gene expression in in vitro activated Bergmann glial cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractIn the central nervous system (CNS), the c‐Jun transcription factor has been mainly studied in neuronal cells and coupled to apoptotic and regenerative pathways following brain injury. Besides, several studies have shown a transcriptional role of c‐Jun in activated cortical and spinal astrocytes. In contrast, little is known about c‐Jun expression and transactivation in Bergmann glial (BG) cells, the radial cerebellar astrocytes playing crucial roles in cerebellar development and physiology. Here, we used neuronal/glial cerebellar cultures from neonatal mice to assess putative functions of c‐Jun in BG cells...
Source: Glia - September 21, 2011 Category: Neurology Authors: Lidia AlbanitoChandrakanth Edamakanti ReddyAnna Maria Musti Tags: Original Article Source Type: research

Problems from Preterm Birth May Return in Adulthoodemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Young adults born prematurely have an increased risk of death, finds study Source: HealthDay Related MedlinePlus Page: Premature Babies
Source: MedlinePlus Health News - September 20, 2011 Category: Consumer Health News Source Type: news

Comparison of Nulliparas Undergoing Cesarean Section in First and Second Stages of Labour: A Prospective Study in a Tertiary Teaching Hospitalemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion. Cesarean section in the second stage of the labour is associated with increased maternal and neonatal morbidities. Special attention is required to the patients undergoing cesarean section in the second stage of the labour.
Source: Computational Intelligence and Neuroscience - September 20, 2011 Category: Neuroscience Source Type: research

Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophreniaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study sought to determine whether Cbl was capable of reducing behavioral and neuronal alterations in nVHL rats. The behavioral analysis included locomotor activity induced by novel environment and amphetamine, social interaction, and sensoriomotor gating. The morphological evaluation included dendritic analysis by using the Golgi‐Cox procedure and stereology to quantify the total cell number in PFC and NAcc. Behavioral data show a reduction in the hyperresponsiveness to novel environment‐ and amphetamine‐induced locomotion, with an increase in the total time spent in social interactions and in prepulse inhibitio...
Source: Journal of Neuroscience Research - September 20, 2011 Category: Neuroscience Authors: Rubén Antonio Vázquez‐RoqueBrenda RamosCarolina TecuatlIsmael JuárezAnthony AdameFidel de la CruzSergio ZamudioRaúl MenaEdward RockensteinEliezer MasliahGonzalo Flores Tags: Research Article Source Type: research

Neonatal repair of right interrupted aortic arch with cerebro-myocardial perfusion technique [Case report - Congenital]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report a case of successful neonatal biventricular repair of a right interrupted aortic arch (type B), with an aberrant right subclavian artery ventricular septal defect (VSD) in a 2.7 kg term neonate with DiGeorge syndrome. Patient presented in severe respiratory distress and acidosis at one day old. Two-dimensional (2D) echocardiography revealed aortic arch interruption beyond the common carotid arteries with large perimembranous outlet VSD. Aortic annulus diameter was 4.8 mm and there was no left ventricle (LV) outflow tract obstruction. Three-dimensional (3D) CT-scan confirmed these findings and identified...
Source: Interactive CardioVascular and Thoracic Surgery - September 20, 2011 Category: Cardiovascular & Thoracic Surgery Authors: Takeuchi, K., Masuzawa, A., Kobayashi, J., Tsuchiya, K. Tags: Case report - Congenital Source Type: research