MedWorm: Adenocarcinoma

Genomic alterations of chromosome region 11p as predictive marker by array comparative genomic hybridization in lung adenocarcinoma patients

Cancer Genetics and Cytogenetics — Thu, 18 Mar 2010 16:03:04 +0100

In this study, we used aCGH to compare genomic alterations in fresh-frozen lung cancer tissues of 21 adenocarcinomas (AdCCs) (11 early relapse and 10 nonrelapse) and identified genomic alterations that showed significant by different frequency between early relapse and nonrelapse AdCCs. Twelve clones were identified by the false discovery rate (FDR) test, and Kaplan-Meier analyses were selected as predictive markers. The significant gain clones were found in 11p (11p15.4, 11p15.1, and 11p13). When the cutoff value was 2, study of the association between candidate clones and relapse prediction revealed that early relapse and nonrelapse groups were most effectively separated. To further validate the gain of chromosome 11p region that was identified by array CGH, fluorescence in situ hybridiz...

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Respiratory epithelial adenomatoid hamartoma of bilateral olfactory clefts associated with nasal polyposis: Three cases report and literature review

Auris, Nasus, Larynx — Thu, 18 Mar 2010 14:19:49 +0100

We report three cases of patients with respiratory epithelial adenomatoid hamartoma (REAH) of bilateral olfactory clefts associated with nasal polyposis. REAH is a kind of rare lesion which commonly occurs in nasal cavity, paranasal sinuses, and nasopharynx. Our cases were all localized in bilateral olfactory clefts which is very rare since the most common site reported in the past in nasal cavity is the posterior nasal septum and unilateral. Furthermore, our presented cases all associated with nasal polyposis which can provide greater evidence that inflammation can induce REAH development. Although REAH is benign lesion it can probably continue developing after operation if REAH was not completely resected. So during endoscopic sinus surgery (ESS), complete resection of the lesions is key...

MFSD2A is a novel lung tumor suppressor gene modulating cell cycle and matrix attachment

Molecular Cancer — Wed, 17 Mar 2010 00:00:00 +0100

Background: MFSD2A (major facilitator superfamily domain containing 2) gene maps on chromosome 1p34 within a linkage disequilibrium block containing genetic elements associated with progression of lung cancer. Results: Here we show that MFSD2A expression is strongly downregulated in non-small cell lung cancer cell lines of different histotypes and in primary lung adenocarcinomas. Experimental modulation of MFSD2A in lung cancer cells is associated with alteration of mRNA levels of genes involved in cell cycle control and interaction with the extracellular matrix. Exogenous expression of MFSD2A in lung cancer cells induced a G1 block, impaired adhesion and migration in vitro, and significantly reduced tumor colony number in vitro (4- to 27-fold, P (Source: Molecular Cancer)

RhoA and PRKCZ control different aspects of cell motility in pancreatic cancer metastatic clones

Molecular Cancer — Wed, 17 Mar 2010 00:00:00 +0100

Conclusion: Herein, we demonstrate a critical role for RHOA and PRKCZ in the regulation of different aspects of cell motility of PDAC and demonstrate the need to inhibit both pathways to obtain a functionally relevant effect in most assays. These results indicate that RHOA and PRKCZ, and their downstream effectors, can represent important pharmacological targets that could potentially control the highly metastatic attitude of PDAC. (Source: Molecular Cancer)

Promoter methylation of sFRP5 in patients with ovarian clear cell adenocarcinoma

European Journal of Clinical Investigation — Wed, 17 Mar 2010 00:00:00 +0100

Conclusion The high percentage of promoter methylation in the sFRP5 gene in OCCA indicates its importance in the development of OCCA and is a potential useful marker for prognoses and target for treatment of OCCA. (Source: European Journal of Clinical Investigation)

Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.

Pathology Oncology Research — Wed, 17 Mar 2010 00:00:00 +0100

This study demonstrates HPV DNA and viral integration in colorectal tumors, suggesting a potential role of this virus in colorectal carcinogenesis. There was no concurrence, however, of k-ras and c-myc activation with viral infection. PMID: 20232185 [PubMed - as supplied by publisher] (Source: Pathology Oncology Research)

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Mesothelioma Subtypes: Do They Really Affect Prognosis?

Asbestos and Mesothelioma News — Tue, 16 Mar 2010 22:40:46 +0100

In conclusion, the researchers found, “The extremely poor prognosis of sarcomatoid malignant pleural mesothelioma is independent of the extent of surgery unlike other cell types. Patients with sarcomatoid histology should therefore be considered separately in trials evaluating radical procedures and adjuvant treatment. The treatment of biphasic pleural mesothelioma remains debatable.” Additional information on mesothelioma may be found through the Mesothelioma Center. (Source: Asbestos and Mesothelioma News)

Dose effect of cigarette smoking on frequency and spectrum of epidermal growth factor receptor gene mutations in Korean patients with non-small cell lung cancer

Journal of Cancer Research and Clinical Oncology — Tue, 16 Mar 2010 14:49:23 +0100

Conclusions Smoking dosage affects the incidence of EGFR mutations. EGFR mutations in exon 19 or 21 are associated with low exposure to cigarette smoke, whereas EGFR mutation in exon 20 is more common in smokers. Content Type Journal ArticleCategory Original PaperDOI 10.1007/s00432-010-0853-4Authors Young Joo Lee, National Cancer Center Center for Clinical Trial Gyeonggi Republic of KoreaHyo Sub Shim, Yonsei University College of Medicine Department of Pathology Seoul Republic of KoreaYoung Ae Kang, Yonsei University College of Medicine Department of Internal Medicine Seoul Republic of KoreaSu Jung Hong, Yonsei University College of Medicine Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine 250 Seongsanno CPO Box 8044 Seodaemun-gu, Se...

Phase II study of sequential cisplatin plus 5-fluorouracil/leucovorin (5-FU/LV) followed by irinotecan plus 5-FU/LV followed by docetaxel plus 5-FU/LV in patients with metastatic gastric or gastro-oesophageal junction adenocarcinoma

Cancer Chemotherapy and Pharmacology — Tue, 16 Mar 2010 14:49:02 +0100

Conclusion This sequential treatment is feasible with a favourable safety profile and produced encouraging results in terms of activity and efficacy. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-009-1196-1Authors Fotios Loupakis, University of Pisa Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Department of Oncology, Transplants and New Technologies in Medicine Via Roma, 67 56126 Pisa ItalyGianluca Masi, University of Pisa Unit of Medical Oncology 2, Azienda Ospedaliero-Universitaria Pisana, Istituto Toscano Tumori and Department of Oncology, Transplants and New Technologies in Medicine Via Roma, 67 56126 Pisa ItalyLorenzo Fornaro, University of Pisa Unit of Medical Oncology 2, Azienda Osp...

SIR: Image-guided nanoembolization - therapy for pancreatic ductal adenocarcinoma

Health Imaging News — Tue, 16 Mar 2010 07:21:13 +0100

A novel pancreas-directed local approach, using image-guided nanoembolization, increases intra-tumoral uptake of therapeutic gold nanoparticles over systemic IV administration in a rabbit model of pancreatic ductal adenocarcinoma (PDAC), according to a presentation at the Society of Interventional Radiology's (SIR) 35th annual scientific meeting in Tampa, Fla. this week. (Source: Health Imaging News)

Mylan S.A.S. Withdraws Its Marketing Authorisation Application For Docetaxel Mylan (docetaxel), Europe

Health News from Medical News Today — Tue, 16 Mar 2010 07:00:00 +0100

The European Medicines Agency has been formally notified by Mylan S.A.S. of its decision to withdraw its application for a centralised marketing authorisation for the medicinal product Docetaxel Mylan (docetaxel), 10mg/ml powder and solvent for solution for infusion. The medicine was developed as a generic medicine to be used for breast cancer, non small cell lung cancer, prostate cancer, gastric adenocarcinoma and head and neck cancer. The reference medicinal product for Docetaxel Mylan is Taxotere, which has been authorised in the European Union since 1995... (Source: Health News from Medical News Today)

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Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma

Cancer Science — Tue, 16 Mar 2010 00:00:00 +0100

Nectin-like molecule-5 (Necl-5) is an immunoglobulin (Ig)-like molecule that is up-regulated in many types of cancer cells. It was shown experimentally that Necl-5 enhances cell migration, proliferation, and metastasis, but its clinical significance has not been documented. The aim of this study was to observe the expression of Necl-5 in surgically resected primary lung adenocarcinomas and to investigate its clinical significance. A total of 63 surgically resected primary pulmonary adenocarcinoma tissues were investigated by immunohistochemistry for the expression of Necl-5. The relationship between expression of Necl-5 and clinicopathological features was analyzed, and the influence of Necl-5 expression on outcomes in these patients was assessed. A strong expression of Necl-5 by cancer ce...

Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study

BMC Cancer — Tue, 16 Mar 2010 00:00:00 +0100

This study investigates the associations between BRAF and K-ras mutations and clinicopathological, lifestyle and dietary factors in colorectal cancers. Methods: 186 adenocarcinomas and 16 adenomas from the EPIC Norfolk study were tested for BRAF and K-ras mutations. Diet and lifestyle data were collected prospectively using seven day food diaries. Results: BRAF V600E mutation was found in 15.6% of colorectal cancers but at higher frequencies in cancers with proximal location, poor differentiation and microsatellite instability (MSI) (all p (Source: BMC Cancer)

Further Refinement of the Optimal Treatment Following Radical Gastric Resection for Gastric Adenocarcinoma: Comment on "Adjuvant Chemoradiotherapy in Patients With Stage III or IV Radically Resected Gastric Cancer" [Invited Critique]

Archives of Surgery — Mon, 15 Mar 2010 19:50:50 +0100

(Source: Archives of Surgery)

Preoperative assessment of para-aortic lymph node metastasis in patients with pancreatic cancer

International Journal of Clinical Oncology — Mon, 15 Mar 2010 17:56:16 +0100

Conclusions Preoperative detection of PALN metastasis in patients with pancreatic cancer is very difficult. Intraoperative histopathological examination of frozen sections is necessary if radical resection is contemplated. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0066-5Authors Hisashi Imai, Kyoto University Department of Hepato-Biliary-Pancreatic Surgery and Transplantation 54 Shogoinkawaracho, Sakyoku Kyoto 606-8507 JapanRyuichiro Doi, Kyoto University Department of Hepato-Biliary-Pancreatic Surgery and Transplantation 54 Shogoinkawaracho, Sakyoku Kyoto 606-8507 JapanHiroyuki Kanazawa, Kyoto University Department of Hepato-Biliary-Pancreatic Surgery and Transplantation 54 Shogoinkawaracho, Sakyoku Kyoto 606-8507 JapanNaoko Kamo, Ky...

Expression of mitochondrial transcription factor A in endometrial carcinomas: clinicopathologic correlations and prognostic significance

Virchows Archiv — Mon, 15 Mar 2010 17:55:00 +0100

This study investigated the relationship between the immunohistochemical expression of mtTFA and various clinicopathological variables in 276 endometrial carcinomas, including 245 endometrioid adenocarcinomas and 31 nonendometrioid carcinomas (21 serous carcinomas and 10 clear cell adenocarcinomas). Both uni- and multivariate regression analyses were performed. The mtTFA labeling index of endometrioid adenocarcinomas ranged from 0% to 98%, with a median value of 32%, which was selected as the cut-off point for mtTFA expression. The mtTFA expression in endometrioid adenocarcinomas was significantly associated with the surgical stage, myometrial invasion, lymphovascular space invasion, cervical invasion, and lymph node metastasis. In contrast, no correlation between clinicopathologic v...

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Aberrant Methylation of Thrombospondin-1 and Its Association with Reduced Expression in Gastric Cardia Adenocarcinoma

Journal of Biomedicine and Biotechnology — Mon, 15 Mar 2010 16:38:59 +0100

Conclusions. Epigenetic silencing of TSP1 gene by promoter hypermethylation may play an important role in GCA. (Source: Journal of Biomedicine and Biotechnology)

Endoscopic resection ‘an essential grading tool’ in Barrett’s HGD and EAC

MedWire News - Gastroenterology — Mon, 15 Mar 2010 14:30:48 +0100

Endoscopic resection can alter histological staging or tumor grading in almost half of patients with Barrett’s high-grade dysplasia and early esophageal adenocarcinoma who undergo biopsy, research suggests. (Source: MedWire News - Gastroenterology)

The Sonodynamic Effects of Chlorin e6 on the Proliferation of Human Lung Adenocarcinoma Cell SPCA-1

Chinese Journal of Lung Cancer — Mon, 15 Mar 2010 13:51:32 +0100

Conclusion There was a significant selectively inhibitory effect of sonodynamic effect with Chlorin e6 on the SPCA-1 cell growth. Chlorin e6 may be a promising sonosensitizing agent for the treatment of non-small cell lung cancer. (Source: Chinese Journal of Lung Cancer)

Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer

Oncogene — Mon, 15 Mar 2010 00:00:00 +0100

Authors: K-S Lee, Y-S Lee, J-M Lee, K Ito, S Cinghu, J-H Kim, J-W Jang, Y-H Li, Y-M Goh, X-Z Chi, H Wee, H-W Lee, A Hosoya, J-H Chung, J-J Jang, J K Kundu, Y-J Surh, W-J Kim, Y Ito, H-S Jung & S-C Bae (Source: Oncogene)

Heterogeneous expression of nestin in myofibroblasts of various human tissues

Pathology International — Mon, 15 Mar 2010 00:00:00 +0100

In conclusion, nestin was expressed in variable proportions of stromal myofibroblasts in human tissues. The differential expression of nestin may indicate phenotypic and functional heterogeneity. Nestin-positive myofibroblast may represent a relatively immature subpopulation of cells with multipotentiality. (Source: Pathology International)

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Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China

Molecular Carcinogenesis — Mon, 15 Mar 2010 00:00:00 +0100

This study, including 361 GAAs and 616 controls without any evidence of tumors, was designed to evaluate the association between the polymorphisms of DNA repair genes XPC Ala499Val (RS#2228000) and Lys939Gln (RS#2228001), XPD Lys751Gln (RS#13181), and XRCC4 Ala247Ser (RS#3734091) and Ser298Asn (RS#1805377), and GAA risk for Guangxi population by means of TaqMan-PCR analysis. Increased risks of GAA were found for individuals with H. pylori positive [odds ratio (OR), 2.48; 95% confidence interval (CI), 1.84-3.33] or cagA positive (OR, 7.34; 95% CI, 5.46-9.87). No differences were observed among the studied groups with regard to the genotype distribution of XPC codons 499 and 939 and of XRCC4 codon 247; but XPD codon 751 genotypes with Gln [ORs (95% CI) were 2.67 (1.98-3.58) and 3.97 (2.64-5....

Sarcomatoid carcinoma of the prostate: a case report.

International Journal of Clinical and Experimental Pathology — Sun, 14 Mar 2010 20:24:03 +0100

We report a case of a 76-year old Caucasian man who underwent transurethral resection of the prostate for the treatment of bladder outlet obstruction. Histopathologic examination revealed a tumor with malignant epithelial and sarcomatous elements. The malignant epithelial component consisted of poorly differentiated adenocarcinoma (Gleason score 5+4=9/10) and the sarcomatous component was mainly composed of undifferentiated spindle cells. On immunohistochemistrythe latter expressed a positive staining for vimentin. Several cells were positively stained for cytockeratin AE3 and myoD1 while all were negative for actin, desmin and myogenin. The diagnosis of sarcomatoid carcinoma was finally made. Although sarcomatoid carcinoma of the prostate is a highly aggressive neoplasm and patients have ...

Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.

Technology in Cancer Research and Treatment — Sun, 14 Mar 2010 07:46:15 +0100

In this study, we used genome-wide microarray-based comparative genomic hybridization (aCGH) technology to characterize five of the more commonly used endometrial cancer cell lines. We detected DNA copy-number gains in chromosomal regions 2q, 3p, 3q, 5q, 7p, 17q, and19q in all five cell lines. Other common sites of copy-number gains, which were detected in four of five cell lines, included segments of chromosomes 1, 6, 8, 9, 11, 12, and 16. In all five cell lines, we found DNA copy-number losses in regions 3p, 10p, 10q, 11q, 11p, 14q, 15q, 18p, and 21q. Other common sites of genetic aberrations included segments of chromosomes 1, 2, 4, 5, 6, 16, 20, and 22. The genes involved in the copy-number alterations included the oncogenes PIK3CA (3q26.3), K-ras (12p12.1), R-ras (19q13.3-qter), Raf-1...

Pfizer Discontinues A Phase 3 Study Of Figitumumab In Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Health News from Medical News Today — Sun, 14 Mar 2010 07:00:00 +0100

Pfizer Inc. announced today the discontinuation of A4021018 (also known as ADVIGO 1018), a Phase 3 trial examining the effects of investigational compound figitumumab (CP-751,871) in combination with erlotinib as a second/third-line treatment in patients with previously treated advanced non-adenocarcinoma non-small cell lung cancer (NSCLC)... (Source: Health News from Medical News Today)

Pfizer Discontinues A Phase 3 Study Of Figitumumab In Previously Treated Patients With Advanced Non-Small Cell Lung Cancer

Cancer / Oncology News From Medical News Today — Sun, 14 Mar 2010 07:00:00 +0100

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Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner.

Cellular and Molecular Life Sciences : CMLS — Sun, 14 Mar 2010 00:00:00 +0100

Authors: Keller-Pinter A, Bottka S, Timar J, Kulka J, Katona R, Dux L, Deak F, Szilak L During mitosis, cells detach, and the cell-matrix interactions become restricted. At the completion of cytokinesis, the two daughter cells are still connected transiently by an intercellular bridge (ICB), which is subjected to abscission, as the terminal step of cytokinesis. Cell adhesion to the matrix is mediated by syndecan-4 (SDC4) transmembrane heparan sulfate proteoglycan. Our present work demonstrated that SDC4 promotes cytokinesis in a phosphorylation-dependent manner in MCF-7 breast adenocarcinoma cells. The serine179-phosphorylation and the ectodomain shedding of SDC4 changed periodically in a cell cycle-dependent way reaching the maximum at G2/M phases. On the contrary, the phospho-resista...

Adenocarcinoma of the esophagogastric junction: relationship between clinicopathological data and p53, cyclin D1 and Bcl-2 immunoexpressions

Arquivos de Gastroenterologia — Sat, 13 Mar 2010 14:23:58 +0100

CONCLUSION: In this selected population, there was no association between the immunomarkers, p53, cyclin D1 and bcl-2 and clinicopathological data and/or overall survival.CONTEXTO: O adenocarcinoma da junção esôfago-gástrica tem um comportamento agressivo e o estádio TNM não é sempre suficiente para categorizar o paciente de acordo com a evolução do mesmo. OBJETIVO: Avaliar a imunoexpressão do p53, ciclina D1 e Bcl-2 em pacientes com adenocarcinoma da junção esôfago-gástrica sem esôfago de Barrett e comparar com as características clínicas e sobrevida. MÉTODOS: Cortes histológicos de 75 adenocarcinomas da esôfago-gástrica ressecados de 1991 a 2003 foram analisados por imunoistoquímica para o p53, ciclina D1 e Bcl-2, usando-se o método da estreptavidina-biotina-peroxi...

Pancreatic adenocarcinoma in type 2 progressive familial intrahepatic cholestasis

BMC Gastroenterology — Sat, 13 Mar 2010 00:00:00 +0100

Conclusions: Clinicians should be aware of the possibility of pancreatic adenocarcinoma in patients with BSEP disease. (Source: BMC Gastroenterology)

RE: "Stage 1, Grade 3 endometrioid adenocarcinoma of the endometrium: An analysis of clinical outcomes and patterns of recurrence"

Gynecologic Oncology — Sat, 13 Mar 2010 00:00:00 +0100

Authors: O'Malley DM, Fader AN, Rasool N PMID: 20231033 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Malignant transformation of ectopic pancreatic cells in the duodenal wall.

World Journal of Gastroenterology : WJG — Fri, 12 Mar 2010 17:04:11 +0100

Authors: Bini R, Voghera P, Tapparo A, Nunziata R, Demarchi A, Capocefalo M, Leli R Ectopic pancreas (EP) is the relatively uncommon presence of pancreatic tissue outside the normal location of the pancreas. This condition is usually asymptomatic and rarely complicated by pancreatitis and malignant transformation. A few cases of neoplastic phenomena that developed from EP into the duodenal wall are described in the literature. Herein we report a case of gastric outlet obstruction due to adenocarcinoma arising from EP of the duodenal wall. The patient underwent a Whipple's procedure and had an uneventful post-operative recovery. Traditional imaging studies are often inconclusive in the definitive diagnosis, whilst endoscopic ultrasonography and guided biopsy may aid accurate pre-operati...

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Alveolar hemorrhage due to erlotinib in non-small-cell lung cancer resistant to gefitinib

Respiratory Medicine CME — Fri, 12 Mar 2010 15:35:02 +0100

Abstract: This is the first report of alveolar hemorrhage due to erlotinib. This patient had received four courses of carboplatin and paclitaxel as first line chemotherapy. Six months later,the level of serum CEA was increased. As cancer cells detected in right bloody pleural effusion indicated an adenocarcinoma showing in frame deletion in exon 19 (E746-A750 del) of epidermal growth factor receptor (EGFR) mutation, gefitinib was administered. The level of serum CEA was decreased for three months. However, the level of serum CEA increased again. Therefore, she was hospitalized to begin erlotinib treatment as third line chemotherapy. She did not respond to erlotinib, but severe alveolar hemorrhage did occur and was suspected to have been a resul of erlotinib administration We should conside...

The right operation for the wrong reason in multi-focal non-small cell lung cancer

Respiratory Medicine CME — Fri, 12 Mar 2010 15:35:02 +0100

Abstract: In a sixty-seven year old female smoker, a right lower lobe mass, intimately related to the mediastinum, was detected on computed tomography (CT) scanning. Bronchoscopy confirmed non-small cell lung cancer (NSCLC) and a subsequent integrated 18F-FDG Positron Emission Tomography (PET)/CT scan demonstrated a rim of non-FDG avid tissue between the lung tumour and the mediastinum, and no nodal or distant metastases. The patient was pre-operatively staged as cT3N0M0 and proceeded to exploratory thoracotomy.On histological examination of the resected right lower lobe, multiple deposits of bronchioalveolar cell carcinoma (BAC) were found surrounding a central adenocarcinoma, in addition to a small deposit of adenocarcinoma in a right upper lobe wedge resection sample. Neither the BAC de...

Cytopathology of the pancreas: neoplastic and nonneoplastic entities

Annals of Diagnostic Pathology — Fri, 12 Mar 2010 15:10:38 +0100

Abstract: Endoscopic ultrasound–directed fine-needle aspiration is a minimally invasive technique for the biopsy of pancreatic cysts and mass lesions. The technique is associated with low morbidity and high diagnostic accuracy. Interpretation of cytologic material obtained from the pancreas is complex because of the large number of reactive processes and benign and malignant neoplasms arising within the pancreas. The cytologic appearances of a majority of pancreatic neoplasms are characteristic, allowing precise recognition of the type of neoplasm present. Whereas separation of neuroendocrine, acinar, and ductal neoplasms is usually straightforward, the greatest diagnostic challenge in pancreatic fine-needle aspiration is the separation of atypical epithelium secondary to chronic pancrea...

Fascin expression in colorectal carcinomas

Clinics — Fri, 12 Mar 2010 14:39:55 +0100

CONCLUSION: These findings suggest that fascin is heterogeneously expressed in approximately one third of colorectal carcinomas with a significant association with lymph node metastasis, tumor stage and location. Moreover, these results indicate that fascin may have a role in the lymph node metastasis of colorectal carcinomas (Source: Clinics)

Metastatic Prostate Cancer in an Asymptomatic Patient with an Initial Prostate-Specific Antigen (PSA) Serum Concentration of 21,380 ng/ml.

Onkologie — Fri, 12 Mar 2010 12:28:05 +0100

Conclusion: This case presents an asymptomatic prostate cancer patient with bone and liver metastasis, enlarged retroperitoneal lymph nodes and the highest PSA level published to date. PMID: 20215802 [PubMed - as supplied by publisher] (Source: Onkologie)

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Anorectal Functional Results After Transanal Endoscopic Microsurgery in Benign and Early Malignant Tumors

World Journal of Surgery — Fri, 12 Mar 2010 06:49:16 +0100

Conclusions Anorectal function was preserved well after TEM, although some anorectal manometric parameters changed over time. Thus TEM is safe, in terms of anorectal function, for the cure of benign and early malignant tumors of the rectum. Content Type Journal ArticleDOI 10.1007/s00268-010-0475-7Authors Zhiming Jin, Shanghai Jiaotong University Department of General Surgery, Shanghai Sixth People’s Hospital, School of Medicine 200233 Shanghai ChinaLu Yin, Shanghai Jiaotong University Department of General Surgery, Shanghai Ruijin Hospital, School of Medicine 200025 Shanghai ChinaLijun Xue, Shanghai Jiaotong University Department of General Surgery, Shanghai Ruijin Hospital, School of Medicine 200025 Shanghai ChinaMoubin Lin, Shanghai Jiaotong University Department...

Generation of a stable anti-human CD44v6 scFv and analysis of its cancer-targeting ability in vitro

Cancer Immunology, Immunotherapy — Fri, 12 Mar 2010 06:49:15 +0100

Abstract CD44v6 is a cancer-associated antigen that mainly expresses in a subset of adenocarcinomas. Therefore, in this study, anti-human CD44v6 single-chain variable fragment (scFv) has been selected and characterized because it is the first step of primary importance towards the construction of a novel cancer-targeted agent for cancer diagnosis and therapy. In our study, anti-human CD44v6 scFv was selected from a human phage-displayed scFv library based on its ability to bind in vitro to CD44v6 antigen. Subsequently, immunofluorescent staining and Western blot analyses were performed to measure the binding characteristics of this scFv. In addition, flow cytometric analysis was done to verify its cancer-targeting ability in vitro. And a flow cytometry-based assay was used...

Pfizer Discontinues A Phase 3 Study Of Figitumumab

World Pharma News — Fri, 12 Mar 2010 00:00:00 +0100

Pfizer Inc. announced the discontinuation of A4021018 (also known as ADVIGO 1018), a Phase 3 trial examining the effects of investigational compound figitumumab (CP-751,871) in combination with erlotinib as a second/third-line treatment in patients with previously treated advanced non-adenocarcinoma non-small cell lung cancer (NSCLC). (Source: World Pharma News)

Sunitinib fails to achieve primary endpoint measures in breast cancer trials

NeLM - News — Fri, 12 Mar 2010 00:00:00 +0100

Source: PharmaTimes Area: News PharmaTimes reports that sunitinib has failed to achieve the primary endpoint measure in 2 phase III studies testing the drug in advanced breast cancer. The SUN 1064 study investigated use of sunitinib with docetaxel for the first-line treatment of patients with advanced HER-2 negative breast cancer but did not show a significant improvement in progression-free survival (PFS) compared to the chemotherapy alone. In the SUN 1099 trial, sunitinib in combination with capecitabine failed to show significant improvements in PFS compared with capecitabine alone in previously-treated advanced breast cancer patients. No further study data are available in the PharmaTimes story. The story also reports that Pfizer (the manufacturer of sunitinib) has also ann...

Inhibition of metastasis-associated lung adenocarcinoma transcript 1 in CaSki human cervical cancer cells suppresses cell proliferation and invasion.

Acta Biochimica et Biophysica Sinica — Thu, 11 Mar 2010 20:32:13 +0100

Authors: Guo F, Li Y, Liu Y, Wang J, Li Y, Li G Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is suggested to be a long (~7 kb) non-coding RNA. MALAT1 is overexpressed in many human carcinomas, but its function remains unknown. To investigate the role of MALAT1 in human cervical cancer progression, we designed and used short hairpin RNA to inhibit MALAT1 expression in CaSki cells and validated its effect on cell proliferation and invasion. Changes in gene expression were analyzed by reverse transcriptase- polymerase chain reaction. Our data demonstrated that MALAT1 was involved in cervical cancer cell growth, cell cycle progression, and invasion through the regulation of gene expression, such as caspase-3, -8, Bax, Bcl-2, and BclxL, suggesting that MALAT1 could have i...

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Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis

International Journal of Clinical Oncology — Thu, 11 Mar 2010 18:14:30 +0100

Abstract Esophageal cancer is the eighth most common incident cancer in the world and ranks sixth among all cancers in mortality. Esophageal cancers are classified into two histological types; esophageal squamous cell carcinoma (ESCC), and adenocarcinoma, and the incidences of these types show a striking variety of geographic distribution, possibly reflecting differences in exposure to specific environmental factors. Both alcohol consumption and cigarette smoking are major risk factors for the development of ESCC. Acetaldehyde is the most toxic ethanol metabolite in alcohol-associated carcinogenesis, while ethanol itself stimulates carcinogenesis by inhibiting DNA methylation and by interacting with retinoid metabolism. Cigarette smoke contains more than 60 carcinogens and...

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

Nature — Thu, 11 Mar 2010 16:40:50 +0100

Authors: Massimo Ammirante, Jun-Li Luo, Sergei Grivennikov, Sergei Nedospasov & Michael Karin Prostate cancer (CaP) progresses from prostatic intraepithelial neoplasia through locally invasive adenocarcinoma to castration-resistant metastatic carcinoma. Although radical prostatectomy, radiation and androgen ablation are effective therapies for androgen-dependent CaP, metastatic castration-resistant CaP is a major complication with high mortality. Androgens stimulate growth and survival of prostate epithelium and early CaP. Although most patients initially respond to androgen ablation, many develop castration-resistant CaP within 12–18 months. Despite extensive studies, the mechanisms underlying the emergence of castration-resistant CaP remain poorly understood and their elu...

Use of Nanoparticles for Targeted, Noninvasive Thermal Destruction of Malignant Cells

Springer protocols feed by Cancer Research — Thu, 11 Mar 2010 13:51:54 +0100

Shortwave (MHz range) radiofrequency (RF) energy is nonionizing, penetrates deeply into biological tissues with no adverse side effects, and heats metallic nanoparticles efficiently. Targeted delivery of these nanoparticles to cancer cells should result in hyperthermic cytotoxicity upon exposure to a focused, noninvasive RF field. We have demonstrated that gold nanoparticles conjugated with cetuximab (C225) are quickly internalized by Panc-1 (pancreatic adenocarcinoma) and Difi (colorectal adenocarcinoma) cancer cells overexpressing epidermal growth factor receptor (EGFR). Panc-1 or Difi cells treated with naked gold nanoparticles or nonspecific IgG-conjugated gold nanoparticles demonstrated minimal intracellular uptake of gold nanoparticles by transmission electron microscopy (TEM). In co...

Synthesis, Characterization, and Functionalization of Gold Nanoparticles for Cancer Imaging

Springer protocols feed by Cancer Research — Thu, 11 Mar 2010 13:51:52 +0100

This chapter describes the methodology by which mAb-F19-conjugated gold nanoparticles were prepared and used to label human pancreatic adenocarcinoma. Specifically, gold nanoparticles were coated with dithiol bearing hetero-bifunctional PEG (polyethylene glycol), and cancer-specific mAb F19 was attached by means of NHS-EDC coupling chemistry taking advantage of a carboxylic acid group on the heterobifunctional PEG. These conjugates were completely stable and were characterized by a variety of methods, including UV–Vis absorbance spectrometry, darkfield microscopy, DLS (dynamic light scattering), TEM (transmission electron microscopy), SEC (size-exclusion chromatography), and confocal microscopy. Nanoparticle bioconjugates were used to label sections of healthy and cancerous human pan...

Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design

Cancer Chemotherapy and Pharmacology — Thu, 11 Mar 2010 07:57:21 +0100

Conclusions Clinical trials may be feasible in second- or third-line salvage chemotherapy for gastric cancer. Future clinical trials in these settings should take into account the low response rate, short progression-free survival, and the prognostic factors for optimal trial design. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1295-zAuthors Yong Wha Moon, Yonsei University College of Medicine Cancer Metastasis Research Center 250 Seongsanno Seodaemun-gu, Seoul 120-752 KoreaSun Young Rha, Yonsei University College of Medicine Cancer Metastasis Research Center 250 Seongsanno Seodaemun-gu, Seoul 120-752 KoreaHei-Cheul Jeung, Yonsei University College of Medicine Cancer Metastasis Research Center 250 Seongsanno Seodaemun-gu, Seoul 120-752...

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Imaging of neuroendocrine gastroenteropancreatic tumours

La Radiologia Medica — Thu, 11 Mar 2010 02:48:48 +0100

Abstract The role of imaging in functioning endocrine tumours (FETs) is primarily to detect the tumour, that is, to verify lesion number and location. Radiological detection of carcinoid tumours is limited by typical tumour location throughout the gastrointestinal tract or appendix and is therefore dependent on the tumour being large enough to make it recognisable in that site. The most common FET is insulinoma, which is commonly characterised by the typical appearance of a hypervascular lesion at multidetector-row computed tomography and magnetic resonance imaging. A particularly important role is played by intraoperative ultrasound in defining the exact number of lesions, their relationship with adjacent vascular structures and the pancreatic duct for the purposes of cor...

The impact of core biopsy fragmentation in prostate cancer

International Urology and Nephrology — Thu, 11 Mar 2010 02:46:28 +0100

Conclusions Considering the ongoing trend for earlier diagnosis of increasing numbers of younger men with low-risk prostate cancer, this study is original and demonstrates the possibility of core fragmentation, explaining in part over- and under-staging. One core per container and an overall Gleason score and percentage of adenocarcinoma for each container are encouraged. Content Type Journal ArticleCategory Urology – Original PaperDOI 10.1007/s11255-010-9720-0Authors Leonardo Oliveira Reis, State University of Campinas – UNICAMP Urologic Oncology Division Votorantim, 51, Ap 43, Vila Nova Campinas São Paulo 13073-090 BrazilJosé Alberto Salvo Reinato, State University of Campinas – UNICAMP Urologic Oncology Division Votorantim, 51, Ap 43, Vila Nova Campinas S...

Distinguishing between primary endocervical and endometrial adenocarcinomas: is a 2-marker (Vim/CEA) panel enough?

Virchows Archiv — Thu, 11 Mar 2010 02:40:39 +0100

In this study, our aim is to investigate whether a 2-marker panel is enough to distinguish between these two gynecologic malignancies. Additionally, we wish to determine which one is the most favorable among eight panels tested, including six 2-marker (ER/CEA, PR/CEA, Vim/CEA, ER/p16INK4a, PR/p16INK4a, Vim/p16INK4a) and two 3-marker (ER/Vim/CEA, ER/Vim/p16INK) panels. A tissue microarray was constructed using paraffin-embedded, formalin-fixed tissues from 35 hysterectomy specimens, including 14 primary endocervical adenocarcinomas and 21 primary endometrial adenocarcinomas. Utilizing the avidin-biotin complex (ABC) method, tissue array sections were immunostained with five commercially available antibodies (ER, Vim, CEA, PR, and p16INK4a) to evaluate their individual frequencies of ex...

Primary large cell neuroendocrine carcinoma of the vagina: Cytomorphology of previously unreported case

Diagnostic Cytopathology — Thu, 11 Mar 2010 00:00:00 +0100

In this report, we describe a case of LCNEC of the vagina, which is believed to be the first case to date in the English literature. The patient is a 53-year old gravida 3, para 2, African-American woman who had a 4 month history of severe pelvic pain and difficulty voiding and was found to have a firm plate-like mass on the anterior vaginal wall. Thin prep of vaginal swap was interpreted as atypical glandular cells; however, the biopsies showed a large cell neuroendocrine carcinoma which was confirmed by diffuse strong immunoreactivity to AE1/3, CAM5.2, CK7, and CD56 in the tumor cells. Subsequent clinical workup showed that the patient also had numerous metastatic nodules in the bilateral lungs and a vaginal-urethral fistula caused by the tumor. The patient underwent palliative radiation...

The antitumor activity of the fungicide ciclopirox

International Journal of Cancer — Thu, 11 Mar 2010 00:00:00 +0100

Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results indicate that CPX inhibited cell proliferation and induced apoptosis in human rhabdomyosarcoma (Rh30), breast carcinoma (MDA-MB231) and colon adenocarcinoma (HT-29) cells in a concentration-dependent manner. By cell cycle analysis, CPX induced accumulation of cells in G1/G0 phase of the cell cycle. Concurrently, CPX downregulated cellular protein expression of cyclins (A, B1, D1 and E) and cyclin-dependent kinases (CDK2 and CDK4) and upregulated expression of the CDK inhibitor...

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Locally Advanced Pancreatic Adenocarcinoma: Where Are We and Where Are We Going? Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

Authors: Richter J, Saif MW Although many cancers have seen a decline in rates due to screening techniques, the lack of viable screening for pancreatic cancer yields a large number of patients presenting with locally advanced and metastatic disease. Interesting new data regarding the management of locally advanced pancreatic cancer was presented at the 2010 ASCO Gastrointestinal Cancers Symposium, January 22-24, Orlando, FL, USA. Crane et al. presented phase II data exploring induction chemotherapy followed by chemoradiotherapy with multiple agents including cetuximab, gemcitabine, oxaliplatin and capecitabine (Abstract #132). Phase II data was also presented examining the role of S-1, an oral fluoropyrimidine, in the locally advanced setting (Abstract #196). In the wake of several stu...

Intraductal Papillary Mucinous Neoplasia (IPMN). Highlights from the "2010 ASCO Gastrointestinal Cancers Symposium". Orlando, FL, USA. January 22-24, 2010.

JOP — Wed, 10 Mar 2010 20:50:03 +0100

Authors: Bussom S, Saif MW The diagnosis and treatment of intraductal papillary mucinous tumors (IPMN) of the pancreas has evolved over the last decade. IPMN is a disease of the ductal epithelium and represent a spectrum of disease, ranging from benign to malignant lesions, making the early detection and characterization of these lesions important. As with villous adenomas of the colon, not all IPMNs will develop into adenocarcinoma. Definitive management is surgical resection for appropriate candidates, as benign lesions harbor malignant potential. Growing controversy revolves around issues of natural history, management of small-branch-duct lesions, ability to predict malignancy and/or progression, and surveillance strategies. Given these controversies, novel methods are needed to he...

A case of rapidly growing pulmonary carcinosarcoma

International Journal of Clinical Oncology — Wed, 10 Mar 2010 16:13:28 +0100

We report herein a case of rapidly growing pulmonary carcinosarcoma, a rare and highly malignant lung neoplasm characterized by a biphasic histopathological pattern consisting of both epithelial and sarcomatous components, and we also summarize the clinical features of this entity based on previously reported cases. A 65-year-old man was referred for further examination of a lung tumor after a routine chest X-ray (CXR) showed a tumor shadow in the right upper lung zone. Chest computed tomography (CT) found a 2.0 cm pulmonary mass with suspected chest wall invasion in the right upper lobe, although cytological evidence of malignancy could not be obtained despite repeated preoperative bronchoscopy. The tumor grew rapidly, indicating the possibility of lung cancer. A right upper lo...

Should Chemoradiotherapy Be Used in Node-Negative Esophageal or Gastric Adenocarcinoma?

Annals of Surgical Oncology — Wed, 10 Mar 2010 16:01:02 +0100

Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-010-1014-3Authors Naveenraj L. Solomon, Dewitt Daughtry Family Department of Surgery, University of Miami School of Medicine Department of Surgical Oncology Miami FL USALeonidas G. Koniaris, Dewitt Daughtry Family Department of Surgery, University of Miami School of Medicine Department of Surgical Oncology Miami FL USA Journal Annals of Surgical OncologyOnline ISSN 1534-4681Print ISSN 1068-9265 (Source: Annals of Surgical Oncology)

Preoperative Radiochemotherapy in T3 Operable Low Rectal Cancers: A Gold Standard?

World Journal of Surgery — Wed, 10 Mar 2010 15:57:18 +0100

Conclusions In T3 operable low rectal cancers, selective postoperative radiochemotherapy yielded similar long-term results regarding recurrence rate and survival as extended preoperative chemoradiation. Content Type Journal ArticleDOI 10.1007/s00268-010-0513-5Authors Claudio Fucini, University of Florence Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery Florence ItalyFilippo Pucciani, University of Florence Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery Florence ItalyClaudio Elbetti, University of Florence Department of Medical and Surgical Critical Care, Section of General and Oncological Surgery Florence ItalyRiccardo Gattai, University of Florence Department of Medical and Su...

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Phase I study of intraperitoneal irinotecan in patients with gastric adenocarcinoma with peritoneal seeding

Cancer Chemotherapy and Pharmacology — Wed, 10 Mar 2010 15:56:06 +0100

Conclusions Intraperitoneally administered CPT-11 was feasible and tolerable. Further, phase II study of IP CPT-11 in gastric cancer patients with peritoneal seeding is warranted. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1272-6Authors Moon Ki Choi, Sungkyunkwan University School of Medicine Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center 50 Irwon-dong, Gangnam-gu Seoul 135-710 KoreaByung-Jin Ahn, Dongguk University Medical Science Research Center Seoul KoreaDong-Seok Yim, The Catholic University of Korea Department of Pharmacology, College of Medicine Seoul KoreaYoung Suk Park, Sungkyunkwan University School of Medicine Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center 50...

Clinicopathological features of colorectal cancer in patients under 40 years of age

International Journal of Colorectal Disease — Wed, 10 Mar 2010 15:33:51 +0100

Conclusions Young men with colorectal cancer in Northern Finland have poorer prognosis than women. Venous invasion is an independent predictor of survival. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00384-010-0914-9Authors Jyrki T. Mäkelä, Oulu University Hospital Department of Surgery Oulu FinlandHeikki Kiviniemi, Oulu University Hospital Department of Surgery Oulu Finland Journal International Journal of Colorectal DiseaseOnline ISSN 1432-1262Print ISSN 0179-1958 (Source: International Journal of Colorectal Disease)

Cancer risk in DES daughters

Cancer Causes and Control — Wed, 10 Mar 2010 13:22:24 +0100

Conclusions Except for an elevated risk of CCA, persisting at older ages, and an increased risk of melanoma at young ages, we found no increased risk of cancer. Longer follow-up is warranted to examine cancer risk at ages when cancer occurs more frequently. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9526-5Authors Janneke Verloop, Netherlands Cancer Institute Department of Epidemiology Plesmanlaan 121 1066 CX Amsterdam The NetherlandsFlora E. van Leeuwen, Netherlands Cancer Institute Department of Epidemiology Plesmanlaan 121 1066 CX Amsterdam The NetherlandsTheo J. M. Helmerhorst, Erasmus MC, University Hospital Rotterdam Department of Obstetrics and Gynaecology Rotterdam The NetherlandsHester H. van Boven, Netherlands Cancer Institute ...

The dextran sulphate sodium (DSS) model of colitis: an overview

Comparative Clinical Pathology — Wed, 10 Mar 2010 13:20:12 +0100

Abstract The dextran sulphate sodium model of colitis has demonstrated several correlations with human inflammatory bowel disease and is deemed suitable for investigating pathogenesis, therapeutic options and the dysplasia–adenocarcinoma sequence of inflammatory bowel disease. It is widely applicable to mice, rats, hamsters and guinea pigs. This review explores the features of this model and identifies areas for further research studies. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00580-010-0979-4Authors Livingstone Solomon, Queens University of Belfast Institute of Clinical Sciences, Department of Surgery Grosvenor Road Belfast BT12 6BJ UKSorsiah Mansor, Queens University of Belfast Department of Pathology Grosvenor Road Belfast BT12 6BJ UKPeter ...

Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma

Breast Cancer Research and Treatment — Wed, 10 Mar 2010 13:17:30 +0100

In conclusion, this study suggests that HAb18G expression is associated with BC progression and prognosis. Further evaluation of this new marker in breast cancer is indicated. Content Type Journal ArticleCategory Preclinical studyDOI 10.1007/s10549-010-0790-6Authors Fangfang Liu, Cancer Hospital of Tianjin Medical University Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research Tianjin 300060 ChinaLifang Cui, Cancer Hospital of Tianjin Medical University Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research Tianjin 300060 ChinaYang Zhang, Fourth Military Medical University Cell Engineering Research Centre & Department of Cell Biology, State Key Laboratory of Cancer Biolo...

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Gene promoter methylation patterns throughout the process of cervical carcinogenesis.

Cellular Oncology — Wed, 10 Mar 2010 13:06:02 +0100

Conclusion: Methylation of previously reported cervical cancer specific genes frequently occurs in normal epithelium. However, frequency of methylation increases during cervical carcinogenesis, with CCNA1 and DAPK as the best markers to distinguish normal/LSIL from HSIL/cancer lesions. PMID: 20208141 [PubMed - in process] (Source: Cellular Oncology)

Specific effects of bortezomib against experimental malignant pleural effusion: a preclinical study

Molecular Cancer — Wed, 10 Mar 2010 00:00:00 +0100

Conclusions: These studies indicate that proteasome inhibition tailored to block NF-kappaB activation of lung adenocarcinoma specifically targets the effusion-inducing phenotype of this tumor. Although the drug has limited activity against advanced solid lung cancer, it may prove beneficial for patients with MPE. (Source: Molecular Cancer)

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective.

European Journal of Medicinal Chemistry — Tue, 09 Mar 2010 21:12:19 +0100

Authors: Abadi AH, Gary BD, Tinsley HN, Piazza GA, Abdel-Halim M The synthesis of novel tadalafil analogues in which the benzodioxole moiety is replaced by 2-bromophenyl; the chiral carbons swing from R,R to R,S, S,R and S,S; the piperazinedione ring is maintained or reduced to the 5-membered imidazolidinedione or thioxoimidazolinone is described. The prepared analogues were evaluated for their capacity to inhibit the cyclic guanosine monophosphate (cGMP) selective phosphodiesterase 5 (PDE5) isozyme and the growth of human HT-29 colon adenocarcinoma cells. The R absolute configuration of C-5 in the beta-carboline-hydantoin and C-6 in the beta-carboline-piperazinedione derivatives was found to be essential for the PDE5 inhibition. In addition, tadalafil analogues that were synthesized f...

Molecular detection of host cytokine expression in

Indian Journal of Medical Microbiology — Tue, 09 Mar 2010 17:15:51 +0100

Hosseini M Eshagh, Oghalaie A, Habibi G, Nahvijoo A, Hosseini Z M, Tashakoripoor M, Mohammadi MIndian Journal of Medical Microbiology 2010 28(1):40-44Background: Helicobacter pylori (Hp) is a bacterium recognised as a main causative agent for the development of chronic active gastritis, peptic ulcer disease, gastric adenocarcinoma and primary gastric lymphoma. Objective: Determination of the levels of IFN-&#947; (pro-inflammatory) and IL-4 (anti inflammatory) cytokine expression as indicators of Th1 and Th2 immune responses in gastric cancer (GC) and non gastric cancer (Non GC) dyspeptic patients by gene specific RT-PCR. Materials and Methods: Biopsy specimens were collected from three groups of gastric cancer (GC=18), non ulcer dyspepsia (NUD = 38) and peptic ulcer patients (PU...

Prognostic significance of focal neuroendocrine differentiation in prostate cancer: Cases with autopsy-verified cause of death

Indian Journal of Urology — Tue, 09 Mar 2010 16:12:01 +0100

Conclusions : Focal NED seems to be a powerful negative prognostic parameter in prostate adenocarcinomas. The outcome of the disease in prostate cancer can be accurately predicted based on focal NED of the tumor cells either alone or in combination with Gleason score. (Source: Indian Journal of Urology)

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Do all patients with carcinoma of the esophagus benefit from treatment at teaching facilities?

Journal of Surgical Oncology — Tue, 09 Mar 2010 00:00:00 +0100

We sought to determine whether patients with esophageal carcinoma benefit from regionalization of care.The Florida Cancer Data System (FCDS) and the Agency for Health Care Administration data sets (1998-2002) were merged and queried.A total of 5,041 patients (87.6% Caucasian vs. 11.1% African American (AA)) demonstrated a median survival time of 9.8 months overall and 23.4 months following surgical resection (P < 0.001). Adenocarcinoma arose predominantly in Caucasian patients (98.1%). Patients with adenocarcinoma (n = 2,248) derived a treatment benefit at a TF (HR = 1.35, P = 0.003), including an improved 90-day mortality following surgery (2.1% vs. 4.0%, P < 0.001). Squamous cell carcinoma (SCC) arose predominantly in AA patients (91.6%). No overall survival benefit at TF was observed (H...

Metastasis of colon cancer to the thyroid gland: A case diagnosed on fine-needle aspirate by a combined cytological, immunocytochemical, and molecular approach

Diagnostic Cytopathology — Tue, 09 Mar 2010 00:00:00 +0100

Fine-needle aspiration (FNA) with cytological evaluation reliably diagnoses primary and secondary thyroid neoplasms. However, identifying the primary origin of a metastatic process involving the thyroid gland is challenging. In particular, metastasis of colon cancer to the thyroid gland is very rare. In this case report, a right lobe solid thyroid nodule in a 66-year-old male was aspirated. FNA cytology showed necrosis and atypical tall columnar cells; since, the patient at age 60 had undergone surgery for a sigmoid-rectal cancer metastasizing to the liver and subsequently to the lung, a suspicion of metastasis from colon cancer was raised. This was corroborated by cell-block immunocytochemistry showing a cytokeratin (CK) 7 negative/CK20-positive staining pattern; thyreoglobulin and TTF-1 ...

Pancreatic adenocarcinoma exerts systemic effects on the peripheral blood myeloid and plasmacytoid dendritic cells: an indicator of disease severity?

BMC Cancer — Tue, 09 Mar 2010 00:00:00 +0100

Conclusions: Our findings points to the involvement of inflammation in the destruction of the blood MDCs and PDCs. Furthermore, the preservation of the blood DCs compartment in PDAC patients seems to benefit their ability to control the disease and survival. (Source: BMC Cancer)

Combining enteral with parenteral nutrition to improve postoperative glucose control.

The British Journal of Nutrition — Tue, 09 Mar 2010 00:00:00 +0100

Authors: Lidder P, Flanagan D, Fleming S, Russell M, Morgan N, Wheatley T, Rahamin J, Shaw S, Lewis S The provision of parenteral nutrition (PN) to 'stressed' patients often results in hyperglycaemia, which may be detrimental. In animal models limited amounts of enteral nutrition (EN) improve intestinal integrity and stimulate intestinal incretin production, which may lead to improved glucose control. We set out to assess if combining EN with PN results in improved glucose homeostasis rather than PN given alone. We conducted a randomised trial in a university teaching hospital of patients undergoing a 'curative' oesophagectomy for adenocarcinoma. Differences between the two intervention groups were assessed for continuous glucose measurement, insulin sensitivity using insulin tolerance...

Overexpression of Smoothened Activates the Sonic Hedgehog Signaling Pathway in Pancreatic Cancer-Associated Fibroblasts.

Clinical Cancer Research — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: These findings implicate overexpression of Smo as a mechanism for the activation of Hedgehog signaling in human pancreatic CAFs and suggest that stromal cells may be a therapeutic target for Smo antagonists in pancreatic cancer. Clin Cancer Res; 16(6); 1781-9. PMID: 20215540 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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Prospective external validation of the "ovarian crescent sign" as a single ultrasound parameter to distinguish between benign and malignant adnexal pathology.

The Ultrasound Review of Obstetrics and Gynecology — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSION:: This study confirms previous reports that the presence of the OCS decreases the likelihood of invasive malignancy in adnexal masses. However it is a poor discriminator between benign and malignant adnexal masses. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20217895 [PubMed - as supplied by publisher] (Source: The Ultrasound Review of Obstetrics and Gynecology)

Treatment options for advanced endometrial carcinoma.

Gynecologic Oncology — Tue, 09 Mar 2010 00:00:00 +0100

CONCLUSIONS: Clinical trials are planned to further explore how to best incorporate novel agents into the current treatment algorithm with the aim to improve the options in both first- and second-line treatments for women with endometrial adenocarcinomas. PMID: 20223510 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Adenocarcinoma of Colon Presenting As Cushing's Syndrome [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Mon, 08 Mar 2010 23:01:30 +0100

(Source: Journal of Clinical Oncology)

Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704 [Gastrointestinal Cancer]

Journal of Clinical Oncology — Mon, 08 Mar 2010 23:01:30 +0100

Conclusion Cellular levels of histone modifications define previously unrecognized subsets of patients with pancreatic adenocarcinoma with distinct epigenetic phenotypes and clinical outcomes and represent prognostic and predictive biomarkers that could inform clinical decisions, including the use of fluorouracil chemotherapy. (Source: Journal of Clinical Oncology)

Positron Emission Tomography-Computed Tomography in Paraneoplastic Neurologic Disorders: Systematic Analysis and Review [Original Contribution]

Archives of Neurology — Mon, 08 Mar 2010 20:50:43 +0100

Conclusion In a paraneoplastic neurologic context, PET-CT improves the detection of cancers when other screening test results are negative, particularly in the setting of seropositivity for a neuronal nuclear or cytoplasmic autoantibody marker of cancer. Published online January 11, 2010 (doi:10.1001/archneurol.2009.336). (Source: Archives of Neurology)

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Endoscopic Resection for Barrett's Esophagus Usually Avoids Surgery

Medscape Gastroenterology Headlines — Mon, 08 Mar 2010 18:04:16 +0100

In patients with Barrett's high-grade dysplasia or early esophageal adenocarcinoma, endoscopic resection improves staging and "dramatically" reduces esophagectomy rates, Australian physicians report. Reuters Health Information (Source: Medscape Gastroenterology Headlines)

NSAID, Statin Use May Cut Cancer Risk With PPI-Treated Barrett's Esophagus

Medscape Hematology-Oncology Headlines — Mon, 08 Mar 2010 13:36:40 +0100

A study shows that nonsteroidal anti-inflammatory drugs and statins can nearly halve the risk for esophageal adenocarcinoma in patients taking proton-pump inhibitors for Barrett's esophagus. Reuters Health Information (Source: Medscape Hematology-Oncology Headlines)

Moderately differentiated colorectal adenocarcinoma as a lymph node metastatic phenotype: comparison with well differentiated counterparts.

BMC Surgery — Mon, 08 Mar 2010 00:00:00 +0100

We examined the differences between the clinicopathological characteristics of the Mod and the Wel groups.Results The lymph node involvement (p (Source: BMC Surgery)

Insulin-like growth factor binding protein-3 gene methylation and protein expression in gastric adenocarcinoma.

Growth Hormone and IGF Research — Mon, 08 Mar 2010 00:00:00 +0100

CONCLUSION: In summary, our study did not observe any influence of IGFBP-3 promoter methylation on protein expression. Moreover we propose that IGFBP-3 immunostaining in gastric tissue may be a useful marker for malignancy. PMID: 20219400 [PubMed - as supplied by publisher] (Source: Growth Hormone and IGF Research)

Alterations of tumor-related genes do not exactly match the histopathological grade in gastric adenocarcinomas.

World Journal of Gastroenterology : WJG — Sun, 07 Mar 2010 00:00:00 +0100

CONCLUSION: Different from the traditional point of view, the well differentiated cancer tissues have more alterations of important tumor-related genes than the poorly differentiated cancer tissues. PMID: 20205286 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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Esme Hadfield (1921-92) and the Wycombe woodworkers

Journal of Medical Biography — Fri, 05 Mar 2010 18:51:03 +0100

This paper reflects on the life and work of Esme Hadfield, an otolaryngologist based at Wycombe General Hospital and, in particular, on her discovery of the link between adenocarcinoma of the paranasal sinuses and wood dust exposure from those in the furniture industry. The paper also explores the woodworking industry that forms the backdrop to her discovery. (Source: Journal of Medical Biography)

The role of oxidative DNA damage, DNA repair, GSTM1, SOD2 and OGG1 polymorphisms in individual susceptibility to Barrett's esophagus

Toxicology and Industrial Health current issue — Fri, 05 Mar 2010 11:44:46 +0100

Determination of the genetic alterations, which play a role in the etiology of Barrett’s esophagus (BE), could help identify high-risk individuals for esophageal adenocarcinoma (EA). The aim of the present study was to investigate the role of oxidative DNA damage, glutathione (GSH) concentration as oxidative stress parameters and DNA repair capacity, GSTM1, SOD1 Ala16Val and OGG1 Ser326Cys genetic polymorphisms as individual susceptibility parameters in the etiology of BE. The study groups comprised BE patients who were clinically diagnosed (n = 40) and a healthy control group (n = 40). Basal DNA damage, pyrimidine and purine base damage after H2O2 induction, H 2O2 sensitivity, DNA repair capacity, oxidized pyrimidine and purine base damage repair were evaluated in peripheral blood l...

Aetiology and classification of adenocarcinoma of the gastro-oesophageal junction/cardia

Gut — Fri, 05 Mar 2010 11:12:50 +0100

(Source: Gut)

Chemotherapy-induced reversible posterior leucoencephalopathy syndrome

Internal Medicine Journal — Fri, 05 Mar 2010 00:00:00 +0100

We describe the case of a 55-year-old woman with advanced pancreatic adenocarcinoma, who developed clinical and radiological manifestations consistent with this syndrome as a complication of gemcitabine monotherapy. (Source: Internal Medicine Journal)

Uterine Tumors with Neuroectodermal Differentiation. A Report of 4 Cases.

Pathology Oncology Research — Fri, 05 Mar 2010 00:00:00 +0100

We report four cases of uterine tumors with neuroectodermal differentiation. One tumor had neuroectodermal component only; in the three other tumors, the neuroectodermal component was admixed with another component, namely rhabdomyosarcoma (1 case), and endometrioid adenocarcinoma (2 cases). Histologically, the neuroectodermal component consisted of small to medium sized cells arranged in diffuse sheets. The tumor cells had round nuclei with stippled to coarsely granular chromatin, mostly with non-prominent nucleoli, and scant eosinophilic or amphophilic cytoplasm. Immunohistochemically, 4/4 tumors showed expression of vimentin, synaptophysin and CD56; 3/4 tumors were CD99 and NSE positive; 2/4 tumors showed focal expression of S-100 protein; and 1/4 tumors had focal dot-like cytoplasmic p...

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HPV genotyping and HPV16 variant analysis in glandular and squamous neoplastic lesions of the uterine cervix.

Gynecologic Oncology — Fri, 05 Mar 2010 00:00:00 +0100

CONCLUSION: Asian American variant of HPV16, HPV18 and HPV45 are preferentially associated with cervical adenocarcinoma as compared to squamous cell carcinoma. PMID: 20207397 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)

Fixed-dose-rate gemcitabine: a viable first-line treatment option for advanced pancreatic and biliary tract cancer.

The Oncologist — Thu, 04 Mar 2010 23:04:03 +0100

Conclusions. Currently available evidence, including this updated analysis, supports the use of FDR-Gem as a first-line option in advanced PDAC, and possibly in BTC, patients and prompts the continued evaluation of this approach in combination regimens. PMID: 20189980 [PubMed - in process] (Source: The Oncologist)

Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells

Journal of Clinical Pathology — Thu, 04 Mar 2010 15:42:50 +0100

Carcinosarcoma of the pancreas is extremely rare and its histogenesis is still unclear. This is a report on a 64-year-old female patient with an intraductal carcinosarcoma arising from intraductal papillary-mucinous carcinoma (IPMC) in the pancreas tail. The carcinosarcoma grew as a polypoid mass within the main pancreatic duct. Histologically, the tumour consisted of adenocarcinoma covering the luminal surface of the lesion with minimal stromal invasion, and osteosarcoma occupying the stroma. Immunohistochemical and gene mutation analyses revealed that both the carcinomatous and sarcomatous tumour cells of the carcinosarcoma, as well as the IPMC cells, expressed TP53 and had identical mutations in KRAS and TP53 genes, indicating that these two neoplastic components of the carcinosarcoma s...

Dendreon Presents Updated IMPACT Results Confirming Provenge Improves Overall Survival in Patients With Metastatic Castrate-Resistant Prostate Cancer

Drugs.com - Clinical Trials — Thu, 04 Mar 2010 13:52:17 +0100

-- Data to be Presented at ASCO-GU Annual Symposium -- SEATTLE, March 3 /PRNewswire-FirstCall/ -- Dendreon Corporation (NASDAQ: DNDN) today announced updated results from its pivotal Phase 3 IMPACT (IMmunotherapy for Prostate AdenoCarcinoma... (Source: Drugs.com - Clinical Trials)

Dendreon Presents Updated IMPACT Results Confirming PROVENGE Improves Overall Survival In Patients With Metastatic Castrate-Resistant Prostate Cancer

Pharma Industry News From Medical News Today — Thu, 04 Mar 2010 13:00:00 +0100

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Dendreon Presents Updated IMPACT Results Confirming PROVENGE Improves Overall Survival In Patients With Metastatic Castrate-Resistant Prostate Cancer

Health News from Medical News Today — Thu, 04 Mar 2010 13:00:00 +0100

Dendreon Corporation (Nasdaq: DNDN) announced updated results from its pivotal Phase 3 IMPACT (IMmunotherapy for Prostate AdenoCarcinoma Treatment) study demonstrating that PROVENGE® (sipuleucel-T) extends overall survival in men with metastatic, castrate-resistant (hormone-refractory) prostate cancer (CRPC). The data will be presented at the American Society of Clinical Oncology 2010 Genitourinary Cancers Symposium (ASCO-GU) in San Francisco on Friday, March 5 at 1:45 pm PT. A sensitivity analysis performed with longer-term follow-up (36... (Source: Health News from Medical News Today)

Evaluation of S-1 as third- or further-line chemotherapy in advanced non-small-cell lung cancer

International Journal of Clinical Oncology — Wed, 03 Mar 2010 08:51:54 +0100

Conclusion S-1 exhibits modest activity and acceptable toxicity when used as a third or subsequent line of chemotherapy in patients with advanced NSCLC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10147-010-0034-0Authors Akira Ono, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun Shizuoka 411-8777 JapanTateaki Naito, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun Shizuoka 411-8777 JapanHaruyasu Murakami, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun Shizuoka 411-8777 JapanToshiaki Takahashi, Shizuoka Cancer Center Division of Thoracic Oncology 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun Shizuoka...

Phase II trial of induction irinotecan-cisplatin followed by concurrent irinotecan-cisplatin and radiotherapy for unresectable, locally advanced gastric and oesophageal-gastric junction adenocarcinoma

Cancer Chemotherapy and Pharmacology — Wed, 03 Mar 2010 08:50:08 +0100

Conclusions Induction IC followed by IC/RT showed poor efficacy and significant toxicity in patients with unresectable GC/EGJC. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1285-1Authors Fernando Rivera, H. U. Marqués de Valdecilla Medical Oncology Department Santander SpainMaica Galán, ICO L′Hospitalet Medical Oncology Department Barcelona SpainJosep Tabernero, Vall d’Hebron University Hospital Medical Oncology Department Barcelona SpainAndres Cervantes, University of Valencia Hematology and Medical Oncology Department, University Hospital Valencia SpainMª Eugenia Vega-Villegas, H. U. Marqués de Valdecilla Medical Oncology Department Santander SpainJavier Gallego, H. General U, Elche Medical Oncology Department Alicante SpainBerta...

Laparoscopic Total Gastrectomy and D2 Lymphadenectomy

Annals of Surgical Oncology — Wed, 03 Mar 2010 08:06:13 +0100

Conclusions Thanks to laparoscopy, a meticulous lymphadenectomy can be performed under excellent view. Advantages, besides rapid recovery of bowel function, include short hospitalization and better cosmesis. Circular stapler esophagojejunostomy can easily be performed by insertion of the anvil transabdominally. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-010-0936-0Authors Giovanni Dapri, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumJacques Himpens, Saint-Pierre University Hospital Department of Gastrointestinal Surgery, European School of Laparoscopic Surgery Brussels BelgiumGuy-Bernard Cadière, Saint-Pierre University Hospital Department of Gast...

A Randomized Controlled Trial: Efficacy and Safety of Azithromycin, Ofloxacin, Bismuth, and Omeprazole Compared With Amoxicillin, Clarithromycin, Bismuth, and Omeprazole as Second-Line Therapy in Patients With Helicobacter pylori Infection

Helicobacter — Wed, 03 Mar 2010 00:00:00 +0100

Conclusion: Two weeks of treatment with ofloxacin, azithromycin, omeprazole, and bismuth is an effective and safe regimen for H. pylori eradication as second-line therapy. (Source: Helicobacter)

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The usefulness of immunohistochemistry in tissue microarrays of Human Papillomavirus negative adenocarcinoma of the uterine cervix

BioMed Central — Wed, 03 Mar 2010 00:00:00 +0100

Conclusions: The immunoprofiles of ADC with the antibodies studied are rather nonspecific. By using immunohistochemistry in 13 HPV negative ADC, endocervical tumour origin was suspected in five CEA positive cases while two out of three vimentin positive samples were probably of endometrial origin, suggesting that CEA and vimentin may be valuable in distinguishing HPV negative cervical adenocarcinomas from endometrial adenocarcinomas. (Source: BioMed Central)

Artifactual hypoglycaemia secondary to leukaemoid reaction

Practical Diabetes International — Wed, 03 Mar 2010 00:00:00 +0100

Artifactual hypoglycaemia presents clinically as asymptomatic hypoglycaemia, and may be associated with an increased white blood cell count. The authors report a case of artifactual hypoglycaemia secondary to leukaemoid reaction in a patient with endometrial adenocarcinoma. Following thorough investigation and exclusion of true hypoglycaemia, this phenomenon was eventually diagnosed. The importance of awareness in the clinically asymptomatic patient of this phenomenon, taking measures to reduce erroneous laboratory glucose results, and confirmatory testing with a glucometer is emphasised. Copyright © 2010 John Wiley & Sons. (Source: Practical Diabetes International)

Prognostic Significance of Tumorigenic Cells With Mesenchymal Features in Pancreatic Adenocarcinoma

JNCI — Tue, 02 Mar 2010 21:01:22 +0100

Conclusions ALDH expression marks pancreatic cancer cells that have stem cell and mesenchymal features. The enhanced clonogenic growth and migratory properties of ALDH-positive pancreatic cancer cells suggest that they play a key role in the development of metastatic disease that negatively affects the overall survival of patients with pancreatic adenocarcinoma. (Source: JNCI)

Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas

Journal of Clinical Investigation — Tue, 02 Mar 2010 17:25:43 +0100

Transformation of epithelial cells is associated with loss of cell polarity, which includes alterations in cell morphology as well as changes in the complement of plasma membrane proteins. Rab proteins regulate polarized trafficking to the cell membrane and therefore represent potential regulators of this neoplastic transition. Here we have demonstrated a tumor suppressor function for Rab25 in intestinal neoplasia in both mice and humans. Human colorectal adenocarcinomas exhibited reductions in Rab25 expression independent of stage, with lower Rab25 expression levels correlating with substantially shorter patient survival. In wild-type mice, Rab25 was strongly expressed in cells luminal to the proliferating cells of intestinal crypts. While Rab25-deficient mice did not exhibit gross pathol...

Adenocarcinoma of the colon and rectum in the Kashmiri population

Indian Journal of Human Genetics — Tue, 02 Mar 2010 17:06:47 +0100

Sameer A Syed, Chowdhri Nissar A, Siddiqi Mushtaq AIndian Journal of Human Genetics 2009 15(3):143-144 (Source: Indian Journal of Human Genetics)

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Study of 5HT3 and HT4 Receptor Expression in HT29 Cell Line and Human Colon Adenocarcinoma Tissues.

Archives of Iranian Medicine — Tue, 02 Mar 2010 12:04:24 +0100

CONCLUSION: The results indicate which 5HT3 and 5HT4 receptors are significantly expressed in both colon cancer tissue and the HT29 cell line. Expression for the 5HT3 receptor is more potent. Furthermore, 5HT plays a mitogenic role in colon cancer cells and antagonists of 5HT3, and 5HT4 receptors can inhibit cancer cell growth. PMID: 20187666 [PubMed - in process] (Source: Archives of Iranian Medicine)

Gene expression profiles of lung adenocarcinoma linked to histopathological grading and survival but not to EGF-R status: a microarray study

BMC Cancer — Tue, 02 Mar 2010 00:00:00 +0100

Conclusions: In this dataset, histopathological tumor grades but not EGFR status were associated with dominant gene expression signatures and gene set enrichment reflecting oncogenic pathway activation, suggesting that high immunohistochemistry EGFR scores may not necessarily be linked to downstream effects that cause major changes in gene expression patterns. Published gene sets showed association with patient survival, however, the small sample size of this study limited the options for a comprehensive validation of previously reported prognostic gene expression signatures. (Source: BMC Cancer)

Value of Magnetic Resonance Spectroscopy Imaging and Dynamic Contrast-Enhanced Imaging for Detecting Prostate Cancer Foci in Men With Prior Negative Biopsy.

Clinical Cancer Research — Tue, 02 Mar 2010 00:00:00 +0100

CONCLUSIONS: The combination of MRSI and DCEMR showed the potential to guide biopsy to cancer foci in patients with previously negative TRUS biopsy. To avoid a potential bias, represented from having taken more samples in group B (mean of cores, 12.17) than in group A (10 cores), in the future a MRSI/DCEMR directed biopsy could be prospectively compared with a saturation biopsy procedure. Clin Cancer Res; 16(6); 1875-83. PMID: 20197480 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

Thioredxin reductase inhibitor ethaselen increases the drug sensitivity of the colon cancer cell line LoVo towards cisplatin via regulation of G1 phase and reversal of G2/M phase arrest

Investigational New Drugs — Mon, 01 Mar 2010 18:09:21 +0100

Summary We evaluated the combination treatment of ethaselen (BBSKE) as a thioredoxin reductase (TrxR) inhibitor plus cisplatin (CDDP) on the human colon adenocarcinoma cell line LoVo. Therapeutic effects ranging from nearly additive to clearly synergistic demonstrated an effective combination, i.e., the cytostatic dose of CDDP could be reduced without a loss in efficacy. To further investigate the cellular response mechanisms of these favorable outcomes, we analyzed the cell-cycle profiles, mRNA expression patterns, and protein levels of several key genes after incubation with BBSKE or CDDP separately and in combination. In appropriate conditions, CDDP induced arrest at the G2/M phase accompanied by the enhanced inhibitory phosphorylation of Cdk1 and the elevated protein e...

Acquired Cisplatin Resistance in Human Lung Adenocarcinoma Cells Is Associated with Enhanced Autophagy

Cancer Biotherapy and Radiopharmaceuticals — Mon, 01 Mar 2010 04:53:44 +0100

Cancer Biotherapy & Radiopharmaceuticals Feb 2010, Vol. 25, No. 1: 75-80. (Source: Cancer Biotherapy and Radiopharmaceuticals)

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[Reflection and Reaction] Benefits and risks of HPV testing in cervical cancer screening

The Lancet Oncology — Mon, 01 Mar 2010 00:00:00 +0100

In this issue of The Lancet Oncology, Ronco and colleagues clarify the benefits and risks of introducing HPV-DNA testing into cervical cancer screening. In a large randomised trial, adding HPV-DNA testing to cytology doubled the detection of cervical intraepithelial neoplasia grade 3 (CIN3) compared with cytology alone, and (presumably, as a direct consequence) no cancers were observed during follow-up of the HPV-testing group compared with nine cases in the cytology group. As noted by the investigators, the increased detection of CIN3 was primarily due to HPV testing, since cytology added little to the sensitivity of screening when combined with HPV testing. These results are consistent with a trial from India that showed decreased cervical cancer incidence and mortality in the HPV-testin...

Metastatic lobular breast adenocarcinoma presenting as cauda equina syndrome

Journal of the Peripheral Nervous System — Mon, 01 Mar 2010 00:00:00 +0100

(Source: Journal of the Peripheral Nervous System)

Immunohistochemical expression of somatostatin receptor subtypes in prostate tissue from cystoprostatectomies with incidental prostate cancer

BJU International — Mon, 01 Mar 2010 00:00:00 +0100

To examine immunohistochemically the expression of the five somatostatin receptors (SSTRs) in cystoprostatectomies (CyPs) with incidental prostate cancer. The five SSTRs (SSTR1[ndash]5) were evaluated in 'normal-looking' epithelium (NEp), high-grade prostatic intraepithelial neoplasia (HGPIN) and pT2a Gleason score 6 adenocarcinoma in 20 CyP specimens with incidental prostate cancer and 20 radical prostatectomy (RP) specimens with clinically detected prostate cancer. For cytoplasm expression, the mean percentage of positive secretory cells with strong cytoplasmic staining increased from NEp to HGPIN and prostate cancer, being slightly lower in the CyP than in the RP specimens. Both in the CyP and RP specimens SSTR4 was found in the highest percentage of cells. There was membrane staining i...

Raman spectral imaging of prostate cancer: can Raman molecular imaging be used to augment standard histopathology?

BJU International — Mon, 01 Mar 2010 00:00:00 +0100

Study Type [ndash] Diagnostic (exploratory cohort)Level of Evidence 2b To evaluate whether Raman molecular imaging (RMI, which combines digital imaging and analytical spectroscopy to evaluate the biochemical composition of interrogated material) can be used to identify biochemical differences in patients with Gleason 7 prostate cancer who progress to metastatic disease and die from prostate cancer. We identified 38 patients who had a radical prostatectomy for Gleason 7 adenocarcinoma of the prostate. Half progressed to metastatic disease and half had no evidence of disease after treatment. Patients were matched for preoperative prostate-specific antigen level, surgical margin status, pathological stage, tumour volume, age at surgery, year of surgery and DNA ploidy. Sequential 5 µm section...

Growth and invasion of sporadic colorectal adenocarcinomas in terms of genetic change.

J Korean Med Sci — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Roh SA, Choi EY, Cho DH, Jang SJ, Kim SY, Kim YS, Kim JC Integrative genetic changes were examined in relation to tumor growth and progression of sporadic colorectal cancers. Ninety-two sporadic colorectal cancer patients and 12 human colorectal cancer cell lines were evaluated. Genetic changes in representative steps of colorectal tumorigenesis were determined. Biological characteristics, i.e., clinicopathologic parameters, expression of invasion-associated molecules, and in vitro invasion and migration, in association with these changes were further analyzed. Adenomatous polyposis coli (APC) and/or Wnt-activated alterations occurred in 66% patients, whereas mismatch repair (MMR) defects and/or RAF-mediated alterations were identified in 47% patients. The crossover rate betwe...

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EUS-guided gold fiducial insertion for image-guided radiation therapy of pancreatic cancer: 50 successful cases without fluoroscopy

Gastrointestinal Endoscopy — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions: EUS-guided fine-needle insertion was safe and effective in delivering gold fiducial markers for image-guided radiation therapy. Fluoroscopy was not required for successful fiducial placement. (Source: Gastrointestinal Endoscopy)

Perforated Sigmoid Colon Cancer within an Irreducible Inguinal Hernia: a Case Report.

Korean J Radiol — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Ko KH, Yu CY, Kao CC, Tsai SH, Huang GS, Chang WC A perforated sigmoid colon cancer within an inguinal hernia is extremely rare. This unexpected finding is usually discovered during surgery and causes an unavoidable septic evolution. Here, we describe the case of an 84-year-old man who presented with fever, abdominal distension, and a painful, enlarged, left scrotum. A CT showed a left, incarcerated, inguinal hernia containing a perforated sigmoid adenocarcinoma (which was confirmed by histopathology). The possibility of an irreducible inguinal hernia in association with perforated sigmoid colon cancer should be considered in the array of diagnoses. A pre-operative CT scan would be helpful in facilitating an accurate diagnosis. PMID: 20191071 [PubMed - in process] (Source:...

Gastroesophageal Reflux Disease and Obesity

Gastroenterology Clinics of North America — Mon, 01 Mar 2010 00:00:00 +0100

Gastroesophageal reflux disease (GERD) is a common condition, with multifactorial pathogenesis, affecting up to 40% of the population. Obesity is also common. Obesity and GERD are clearly related, both from a prevalence and causality association. GERD symptoms increase in severity when people gain weight. Obese patients tend to have more severe erosive esophagitis and obesity is a risk factor for the development of Barrett's esophagus and adenocarcinoma of the esophagus. Patients report improvement in GERD when they lose weight and there are several reports suggesting a decrease in GERD symptoms after bariatric surgery. At present, there is little evidence that obesity has any effect on the efficacy of antisecretory therapy, with conflicting data on surgical outcomes. This review attempts ...

Pseudoneoplastic mimics of prostate and bladder carcinomas.

Archives of Pathology and Laboratory Medicine — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions.-Pseudoneoplastic lesions in the prostate include those of prostatic epithelial origin, the most common being atrophy, adenosis (atypical adenomatous hyperplasia), basal cell hyperplasia, and crowded benign glands, as well as those of nonprostatic origin, such as seminal vesicle epithelium. Such lesions often mimic lower-grade prostatic adenocarcinoma, whereas others, such as clear cell cribriform hyperplasia and granulomatous prostatitis, for example, are in the differential diagnosis of Gleason adenocarcinoma, Gleason grade 4 or 5. Pseudoneoplastic lesions of the urinary bladder include lesions that could potentially be confused with urothelial carcinoma in situ, such as reactive urothelial atypia, and others, such as polypoid/papillary cystitis, where papillary urothelial ne...

Pseudoneoplastic lesions of the female genital tract.

Archives of Pathology and Laboratory Medicine — Mon, 01 Mar 2010 00:00:00 +0100

Conclusions.-Many benign hyperplastic or reactive processes that occur in the female genital tract may be mistaken for neoplasms both clinically and pathologically. Awareness of the features of such lesions will aid in their correct diagnosis and prevent overtreatment of benign processes. PMID: 20196667 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

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Papillary adenocarcinoma arising in a tubular duplication of the jejunum.

The British Journal of Radiology — Mon, 01 Mar 2010 00:00:00 +0100

In this report, we present the first case of papillary adenocarcinoma arising in a tubular duplication of the jejunum. Coronal reformatted images from contrast-enhanced CT revealed a well-enhanced tubular mass in the distal jejunum with small bowel obstruction. There were multiple enlarged lymph nodes in the small bowel mesentery around the superior mesenteric artery. The typical macroscopic and histological findings were present. PMID: 20197430 [PubMed - in process] (Source: The British Journal of Radiology)

Ornithine decarboxylase mRNA expression in curatively resected non-small-cell lung cancer.

Clinical Lung Cancer — Mon, 01 Mar 2010 00:00:00 +0100

Conclusion: In this study, ODC is shown to have a prognostic potential in NSCLC. Low levels of tODC expression are associated with a more aggressive tumor biology. Also, an increase of ODC mRNA expression during carcinogenesis seems to have a favorable prognostic effect. Measuring the ODC expression in patients with NSCLC could aid in further chemotherapy decisions. Our results suggest that further investigation of ODC mRNA expression in NSCLC may be warranted. PMID: 20199977 [PubMed - in process] (Source: Clinical Lung Cancer)

Editorial Comment

Urology — Mon, 01 Mar 2010 00:00:00 +0100

Prostatic adenocarcinoma is a major public health menace, taking the lives of almost 30 000 men annually in the United States. Generally, asymptomatic until metastatic, and at that point, median survival is 30-36 months, a statistic that has changed little since the advent of hormonal therapy. The advent of PSA screening provided an opportunity to identify early disease and more than half of men in the United States undergo screening annually; most men who are diagnosed with this disease undergo treatment. Initial results of two phase 3 screening studies provide a insight into this approach to disease control: in a United States study, no reduction in mortality was seen and in a European study, to prevent 1 prostate cancer death, 1410 men were screened and 48, treated. The people in the Un...

A Retrospective Review of the Effect of a Simple Foot Immobilization Device for the Treatment of Prostate Cancer

Journal of Medical Imaging and Radiation Sciences — Mon, 01 Mar 2010 00:00:00 +0100

Conclusion: The foot strap is a simple and inexpensive method of improving daily setup reliability and reducing the need for isocenter shifts.Résumé: Contexte: La radiothérapie radicale vise à éradiquer les cellules tumorales en donnant des doses maximales au volume ciblé. Il est donc nécessaire d'assurer un positionnement quotidien précis pour réduire les possibilités de rater la cible et minimiser les doses atteignant le tissu normal avoisinant. De nombreuses études ont été menées afin de déterminer le meilleur appareil d'immobilisation permettant d'améliorer la reproductibilité de la position des hommes atteints d'un cancer de la prostate et dont les traitements ne sont pas concluants.Objectif: Une évaluation rétrospective de la consistance et de la reproductibilité ...

[Survival benefit of an herbal formula for invigorating spleen for elderly patients with gastric cancer.]

Zhong xi yi jie he xue bao : Journal of Chinese Integrative Medicine. — Mon, 01 Mar 2010 00:00:00 +0100

Conclusion: The herbal formula for invigorating spleen has an important value for improving the prognosis of elderly patients with gastric cancer. This herbal formula show survival benefit for advanced gastric cancer in elderly patients. The influence of TCHM on disease-free survival and overall survival of postoperative gastric cancer in elderly patients need to be further evaluated. PMID: 20226143 [PubMed - in process] (Source: Zhong xi yi jie he xue bao : Journal of Chinese Integrative Medicine.)

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[Appendicular cystadenocarcinoma with cutaneous fistula.]

Annales de Dermatologie et de Cenereologie — Mon, 01 Mar 2010 00:00:00 +0100

We report a case of fistular lesions of the buttocks revealing a mixed tumour of the appendix involving mucinous cystadenocarcinoma and carcinoid tumour. CASE REPORT: A 67-year-old woman was admitted for four skin fistulae of the right buttock present for 6 years. Histological examination of skin biopsy specimens identified infiltration of the dermis by metastatic mucinous adenocarcinoma while colonoscopy showed a caecal tumour measuring 4cm. Surgical excision was performed involving right hemicolectomy, evacuation of retroperitoneal mucin collection and excision of fistulae. Histopathological examination of surgical specimen confirmed mixed tumour consisting of perforated mucinous cystadenocarcinoma and carcinoid tumour of the appendix. Recurrence of the fistular lesions was seen. The pat...

Estrogen-Producing Ovarian Adenocarcinoma with Large Abscess Formation

Gynecologic and Obstetric Investigation — Sun, 28 Feb 2010 23:00:00 +0100

Gynecol Obstet Invest 1993;35:245-248 (DOI:10.1159/000292710) (Source: Gynecologic and Obstetric Investigation)

Reliability of the 34betaE12, keratin 5/6, p63, bcl-2, and AMACR in the diagnosis of prostate carcinoma.

Urologic Oncology — Sat, 27 Feb 2010 00:00:00 +0100

CONCLUSIONS: As a result, we suggest that keratin 5/6 and bcl-2 should not be used to identify benign glands in prostate biopsy since they show high positivity in malignant glands and high negativity in benign glands. 34betaE12 should be the first choice as a basal cell marker. p63 can be used together with 34betaE12, but it may not give additional diagnostic information. When we evaluated the correlation of basal cell markers, we did not find any complementary staining results among basal cell markers. Our study showed that 34betaE12 is the most appropriate negative marker to combine with AMACR as a positive marker for the diagnosis of prostate adenocarcinoma. PMID: 20189848 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

Med Sci Monit 2010; 16(3):MT22-27 "Double-balloon endoscopy for small intestinal disease: A single-center experience in Hungary"

Medical Science Monitor — Fri, 26 Feb 2010 19:37:00 +0100

Conclusions: Based on our experience, DBE is a safe and useful method for evaluating and treating small-bowel disease in selected patients with obscure bleeding, IBD or polyposis syndromes. The concordance of DBE and CE in this real-life setting was only fair. (Source: Medical Science Monitor)

Massive Hematuria from the Bilateral Upper Urinary Tract in a Patient Treated for Advanced Lung Cancer with Gefitinib

Japanese Journal of Clinical Oncology — Fri, 26 Feb 2010 16:57:32 +0100

We report a case of gefitinib-induced bilateral upper urinary tract bleeding in an 82-year-old woman administered the drug daily for advanced non-small cell adenocarcinoma of the lung (T4N3M0). Hematuria is an uncommon adverse effect of gefitinib, and in most cases, the bleeding site is unknown. On the 44th day of oral gefitinib administration, the patient noted asymptomatic macroscopic bloody urine. Cystoscopy revealed bleeding from the bilateral ureteric orifices without hemorrhagic inflammation of the bladder. One week later, she was admitted complaining of severe abdominal pain, and her condition was found to be complicated by liver damage and renal dysfunction. We stopped gefitinib administration and started hydration and diuresis. Renal function and urine output soon recovered, and a...

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CK7, CK20, CDX2 and MUC2 Immunohistochemical Staining Used To Distinguish Metastatic Colorectal Carcinoma Involving Ovary from Primary Ovarian Mucinous Adenocarcinoma

Japanese Journal of Clinical Oncology — Fri, 26 Feb 2010 16:57:31 +0100

Conclusion CK7, CK20, CDX2 and MUC2 IHC staining is a useful adjunctive diagnostic tool to differentiate MCAOs from POMAs, in addition to clinical history and gross and microscopic findings. (Source: Japanese Journal of Clinical Oncology)

Prostaglandin EP2 Receptor Expression is Increased in Barrett's Oesophagus and Oesophageal Adenocarcinoma

Medscape Today Headlines — Fri, 26 Feb 2010 12:04:24 +0100

The prostaglandin E2 receptor subtype EP2 could be a selective target for prevention and treatment of the Barrett's-associated adenocarcinomas Alimentary Pharmacology & Therapeutics (Source: Medscape Today Headlines)

A novel method for sample preparation of fresh lung cancer tissue for proteomics analysis by tumor cell enrichment and removal of blood contaminants

Proteome Science — Fri, 26 Feb 2010 00:00:00 +0100

Conclusion: The method is feasible and reproducible. We could obtain a fair enrichment of cells but the major benefit of the method was an effective removal of contaminants from red blood cells and plasma proteins resulting in larger proteome coverage compared to the direct lysis of frozen samples. This sample preparation method may be successfully implemented for the discovery of lung cancer biomarkers on tissue samples using mass spectrometry-based proteomics. (Source: Proteome Science)

Non-small cell lung carcinoma of the superior sulcus: The evolution of treatment outcomes with multimodality treatment at a single institution

Journal of Surgical Oncology — Fri, 26 Feb 2010 00:00:00 +0100

We evaluated the efficacy of the multimodality approach in treating superior sulcus non-small cell lung carcinoma (SS NSCLC).We retrospectively analyzed the records of 57 patients with SS NSCLC who were treated at our institution between 1982 and 2007.During the study period, 3- and 5-year survival increased significantly from 42.6% and 42.6% in the first half of the study period (1982-1994) to 72.7% and 65.4% in the second half (1995-2007), respectively. Methods of clinical staging were unchanged between the two time periods, although the ratio of adenocarcinoma was increased, and multimodality treatment, particularly concurrent chemoradiotherapy followed by surgical resection, was used more frequently in the second half of the study period. The 5-year survival of patients who received pr...

Multimodal treatment of patients with minor salivary gland cancer in the case of recurrent disease

Head and Neck — Fri, 26 Feb 2010 00:00:00 +0100

Our aim in this study was to identify prognostic factors and the optimal therapeutic management in patients with minor salivary gland carcinomas.Overall and disease-free survival and overall survival after recurrence in patients with adenoidcystic carcinoma (n = 25), mucoepidermoid carcinoma (n = 8), adenocarcinoma (n = 5), carcinoma ex pleomorphic adenoma (n = 4), and others (n = 5) were correlated to clinical data.Overall survival correlated to treatment modality (p = .039) and T classification (p = .003), whereas prolonged disease-free interval correlated to treatment (p < .001) and T classification (p = .009). Overall survival after recurrence correlated to treatment of recurrence (p = .006) and initial T classification (p = .02). Multivariate analysis showed that overall survival afte...

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The diagnostic utility of immunohistochemistry in distinguishing primary skin adnexal carcinomas from metastatic adenocarcinoma to skin: an immunohistochemical reappraisal using cytokeratin 15, nestin, p63, D2-40, and calretinin

Modern Pathology AOP — Fri, 26 Feb 2010 00:00:00 +0100

Authors: Meera Mahalingam, Lisa P Nguyen, Joanna E Richards, Alona Muzikansky & Mai P Hoang (Source: Modern Pathology AOP)

Immune-mediated pancytopenia induced by oxaliplatin: a case report.

Transfusion — Fri, 26 Feb 2010 00:00:00 +0100

CONCLUSIONS: Our case convincingly demonstrates that oxaliplatin led to the production of drug-dependent PLT, RBC, and WBC antibodies inducing pancytopenia in the patient. The oxaliplatin was discontinued and patient's hematologic values recovered to normal levels. PMID: 20210930 [PubMed - as supplied by publisher] (Source: Transfusion)

Supraclavicular lymph node metastasis as the initial presentation of primary fallopian tube carcinoma

International Journal of Clinical Oncology — Thu, 25 Feb 2010 17:55:58 +0100

Abstract Supraclavicular lymph node metastasis is a rare presentation of primary fallopian tube carcinoma. A 76-year-old woman presented with an enlarged supraclavicular lymph node. A biopsy was performed, and its findings confirmed metastatic adenocarcinoma. Subsequent exploratory laparotomy revealed right fallopian tube carcinoma as the primary lesion; consequently, right salpingo-oophorectomy was performed. After adjuvant chemotherapy, she underwent a laparotomy with total abdominal hysterectomy, left salpingo-oophorectomy, pelvic and para-aortic lymph node sampling, and omentectomy. Supraclavicular lymph node metastasis was thought to be, although rarely, the first manifestation of primary fallopian tube carcinoma (PFTC). When supraclavicular lymph node metastasis of a...

Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma.

World Journal of Gastroenterology : WJG — Thu, 25 Feb 2010 17:40:42 +0100

CONCLUSION: In stage II adenocarcinoma of the pancreatic head and uncinate process, serum bilirubin, histological differentiation and adjuvant chemotherapy were independent prognostic factors, and en-bloc vascular resection is a feasible option in carefully selected patients. PMID: 20180240 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

Phase II study of erlotinib for chemotherapy-naïve patients with advanced or metastatic non-small cell lung cancer who are ineligible for platinum doublets

Cancer Chemotherapy and Pharmacology — Thu, 25 Feb 2010 06:49:57 +0100

Conclusions For unselected chemotherapy-naïve Asian patients with NSCLC but ineligible for platinum doublets, empirical use of upfront erlotinib could not be recommended because of poor survival outcome. However, this can be given to selected subsets based on molecular or clinical predictors. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00280-010-1280-6Authors Dae Ho Lee, University of Ulsan College of Medicine Department of Oncology Asan Medical Center, 388-1 Pungnap-2 dong, Songpa-gu Seoul 138-736 KoreaSang-We Kim, University of Ulsan College of Medicine Department of Oncology Asan Medical Center, 388-1 Pungnap-2 dong, Songpa-gu Seoul 138-736 KoreaCheolwon Suh, University of Ulsan College of Medicine Department of Oncology Asan Medical Center...

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Current State of Gastric Stump Carcinoma in Japan: Based on the Results of a Nationwide Survey

World Journal of Surgery — Thu, 25 Feb 2010 06:49:25 +0100

Conclusions This large series of surveys suggest that there are two distinct biological plausibilities in the development of gastric stump carcinoma: (1) it develops in a shorter time interval of 10 years or less since the original gastrectomy, may come from a higher risk of gastric mucosa after gastrectomy for cancer diseases that highly predisposes to cancer, and (2) it develops during a longer time interval of 20 years or more, may come from gastrectomy-relating mechanisms after gastrectomy for original benign diseases. Content Type Journal ArticleDOI 10.1007/s00268-010-0505-5Authors Nobuhiko Tanigawa, Osaka Medical College Department of General and Gastroenterological Surgery 17-2, Daigaku-Machi Takatsuki City Osaka 569-8686 JapanEiji Nomura, Osaka M...

Could recombinant insulin compounds contribute to adenocarcinoma progression by stimulating local angiogenesis?

Diabetologia — Thu, 25 Feb 2010 06:46:35 +0100

Conclusions/interpretation Our results suggest that all tested insulin compounds may stimulate tumour growth by enhancing local angiogenesis. Future studies need to confirm the association between insulin therapy in type 2 diabetes and tumour progression. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/s00125-010-1687-yAuthors K. L. Rensing, Academic Medical Center/University of Amsterdam Department of Vascular Medicine Meibergdreef 9 1105 AZ Amsterdam the NetherlandsF. M. Houttuijn Bloemendaal, Academic Medical Center/University of Amsterdam Department of Vascular Medicine Meibergdreef 9 1105 AZ Amsterdam the NetherlandsE. M. Weijers, VU University Medical Center Institute for Cardiovascular Research, Laboratory for Physiology Amsterdam the Nethe...

Targeted HER2 Treatment in Advanced Gastric Cancer.

Oncology — Thu, 25 Feb 2010 00:00:00 +0100

Authors: Jørgensen JT Amplification of the HER2 gene and over-expression of the HER2 protein in gastric cancer have been shown in a large number of studies. HER2 positivity can be detected in approximately 20% of patients, which is a characteristic associated with poor prognosis. Preclinical in vitro and in vivo studies have demonstrated that both trastuzumab and lapatinib are effective in different gastric cancer models and have thus lead to the initiation of clinical studies. In the first phase III study, the ToGA trial, HER2-positive patients with advanced gastroesophageal and gastric adenocarcinoma were randomized to receive 5-fluorouracil/capecitabine and cisplatin either alone or in combination with trastuzumab. A statically significant gain in overall survival was seen in t...

Paraneoplastic exudative retinal detachment associated with adenocarcinoma of the lung.

European Journal of Ophthalmology — Thu, 25 Feb 2010 00:00:00 +0100

Conclusions. Paraneoplastic phenomena should be considered in patients presenting with ERD. Ocular paraneoplastic pathologies may be the initial manifestation of an underlying malignancy. PMID: 20213612 [PubMed - as supplied by publisher] (Source: European Journal of Ophthalmology)

Favorable Response to Erlotinib in a Lung Adenocarcinoma With Both Epidermal Growth Factor Receptor Exon 19 Deletion and K-ras G13D Mutations [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Wed, 24 Feb 2010 23:01:03 +0100

(Source: Journal of Clinical Oncology)

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Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09 [Genitourinary Cancer]

Journal of Clinical Oncology — Wed, 24 Feb 2010 23:01:02 +0100

Conclusion This randomized controlled trial shows superior long-term cancer control for men with localized prostate cancer receiving high-dose versus conventional-dose radiation. This was achieved without an increase in grade ≥ 3 late urinary or rectal morbidity. (Source: Journal of Clinical Oncology)

Primary colorectal signet-ring cell carcinoma: Clinicopathological features and postoperative survival

Surgery Today — Wed, 24 Feb 2010 15:49:46 +0100

Conclusion The most important feature of primary colorectal signet-ring cell carcinoma is the advanced stage at the time of diagnosis. In addition, the postoperative survival is worse than for other types of colorectal cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-4057-yAuthors Tsunekazu Mizushima, Izumisano Municipal Hospital Department of Surgery, Rinku General Medical Center Izumisano, Osaka JapanMasaya Nomura, Osaka General Medical Center Department of Surgery Osaka JapanMakoto Fujii, Osaka Kosei-Nenkin Hospital Department of Surgery Osaka JapanHiroki Akamatsu, Osaka Police Hospital Department of Surgery Osaka JapanHitoshi Mizuno, Izumisano Municipal Hospital Department of Surgery, Rinku General Medical Center Izumisano, Osak...

Small peripheral lung adenocarcinoma: Clinicopathological features and surgical treatment

Surgery Today — Wed, 24 Feb 2010 15:49:40 +0100

Abstract The clinical use of high-resolution computed tomography (CT) has greatly advanced diagnosis of small peripheral lesions of the lung. In CT images, these lesions often exhibit ground-glass opacity (GGO). Ground-glass opacity is typical of noninvasive bronchioloalveolar carcinoma (BAC), which is characterized by a lepidic pattern of cells that line the alveoli but do not invade neighboring structures. Bronchioloalveolar carcinoma is classified as a subset of lung adenocarcinoma, but has distinct clinical and pathological features and a favorable prognosis. Most small peripheral lung lesions, including BAC, probably originate in the epithelium of the peripheral airway. As with other subsets of non-small cell lung cancer, surgical resection is a potentially curative t...

Three esophageal cancer cell lines derived from other tumor types

MedWire News - Gastroenterology — Wed, 24 Feb 2010 14:34:03 +0100

Three common human esophageal adenocarcinoma cell lines used in clinical research have been shown by research to be derived from other tumor types. (Source: MedWire News - Gastroenterology)

Two-Staged Surgery for Metastatic Liver Tumor in Morbidly Obese Individual-Left Hemihepatectomy Following Placement of Laparoscopic Adjustable Gastric Band

Obesity Surgery — Wed, 24 Feb 2010 06:55:31 +0100

Abstract A 47-year-oldmale with a body mass index (BMI) 37.12 kg/m2 was diagnosed with an ill-demarcated tumor within IVB segment of left lobe of the liver. Sixteen months earlier, he underwent laparoscopic gastric banding for morbid obesity (BMI 51 kg/m2). One year after bariatric procedure, he was diagnosed with rectal adenocarcinoma. Following abdominoperineal resection of rectum with total mesorectal excision and 2 months course of adjuvant FOLFOX chemotherapy, he was scheduled for liver resection. Left hemihepatectomy was performed with no major complications; wound discharge was successfully treated in outpatient clinic. Twelve months following surgery, he remains disease free with no evidence of local recurrence, metachronic primary tumor, or distant m...

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A phase 2 study of SP1049C, doxorubicin in P-glycoprotein-targeting pluronics, in patients with advanced adenocarcinoma of the esophagus and gastroesophageal junction

Investigational New Drugs — Wed, 24 Feb 2010 06:50:30 +0100

Conclusion SP1049C has a notable single-agent activity in patients with adenocarcinoma of the esophagus and GEJ, as well as an acceptable safety profile. These results, in addition to the results of preclinical studies demonstrating superior antitumor activity of SP1049C compared with doxorubicin in a standard formulation, indicate that further evaluations of SP1049C alone or combined with other relevant therapeutics in this disease setting are warranted. Content Type Journal ArticleCategory PHASE II STUDIESDOI 10.1007/s10637-010-9399-1Authors Juan W. Valle, Christie Hospital NHS Trust Department of Medical Oncology Wilmslow Road Manchester M20 4BX UKAnne Armstrong, Christie Hospital NHS Trust Department of Medical Oncology Wilmslow Road Manchester M20 4BX UKChris Newman, Suprate...

Significance of occult neoplastic cells on tumor metastasis: a case report of gastric cancer

Diagnostic Pathology — Wed, 24 Feb 2010 00:00:00 +0100

Conclusions: In the present case, at least some of ONCs seem to form the microaggregates of tumor cells in lymph nodes, anchor in the sinuses, and grow up to the large tumorous lesion. Even if most of the ONCs were trapped and disappeared under the influence of tumor immunity, the detection of ONCs could be one of the reliable clues to estimate the prognosis. (Source: Diagnostic Pathology)

The cisplatin, epirubicin, 5-fluorouracil, gemcitabine (PEFG) regimen in advanced biliary tract adenocarcinoma

Cancer — Wed, 24 Feb 2010 00:00:00 +0100

In this study, the authors assessed the activity and safety of this combination regimen in patients with advanced BTA.PEFG (cisplatin 40 mg/m2 and epirubicin 40 mg/m2 on Day 1; gemcitabine 600 mg/m2 on Days 1 and 8; and 5-fluorouracil [FU] 200 mg/m2 daily as a continuous infusion) was administered to chemotherapy-naive patients who had a cytologic or histologic diagnosis of locally advanced or metastatic BTA, aged [le]75 years, and a performance status (PS) >60 either until they had evidence progressive disease or for a maximum of 6 months. Tumor size was assessed every 2 months during treatment.Between May 1999 and December 2005, 37 patients (62% metastatic) who had a median age of 62 years and a median PS of 90 received the PEFG regimen at the authors' institution. Primary tumor sites we...

Cetuximab and chemoradiation for rectal cancer-is the water getting muddy?

Acta Oncologica — Wed, 24 Feb 2010 00:00:00 +0100

Conclusion. Cetuximab combined with fluoropyrimidine-based chemoradiation is not currently recommended. A better understanding of the mechanisms involved in combinations of chemotherapy and radiotherapy might allow more effective future scheduling of biological and chemical agents in combination with radiation. PMID: 20180626 [PubMed - as supplied by publisher] (Source: Acta Oncologica)