MedWorm: Angiosarcoma

Postradiation Cutaneous Angiosarcoma After Breast CancerPostradiation Cutaneous Angiosarcoma After Breast Cancer

Medscape Today Headlines — Mon, 06 Feb 2012 04:00:00 +0100

This study compared MYC expression in these patients with control cases. Modern Pathology (Source: Medscape Today Headlines)

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Giant Diaphragmatic Angiosarcoma of Adult: A Case Report and Review of Literature

Journal of Nanomaterials — Wed, 01 Feb 2012 11:29:42 +0100

We present the case of an adult patient who had a primary giant angiosarcoma of the left-sided diaphragm. (Source: Journal of Nanomaterials)

Angiosarcoma of skull in a pregnant woman: case report and review of the literature.

Turkish Neurosurgery — Mon, 30 Jan 2012 05:00:02 +0100

Authors: Samadian M, Rakhshan M, Haddadian K, Rezaei O, Zamani S, Khormaee F Abstract Angiosarcoma is a rare tumor of bone that uncommonly involves the skull. Primary neoplasms of the skull represent 2.6% of primary neoplasms of bone. We wish to report a case of angiosarcoma of he skull in an 18-year-old pregnant woman who presented with a rapidly growing left frontotemporal mass. Neuroimaging revealed a left frontotemporal mass with destruction of diploic space and both tables and with extension to the subgaleal and epidural spaces. The patient underwent surgery and the tumor was removed totally. Histological features of angiosarcoma were seen in the pathology study. She received adjuvant chemotherapy and radiation therapy. She has remained well during 6 years of f...

Liver angiosarcoma, a rare liver malignancy, presented with intraabdominal bleeding due to rupture- a case report

World Journal of Surgical Oncology — Thu, 26 Jan 2012 05:00:00 +0100

Liver angiosarcoma is a rare disease, however it still ranks as the third of most common primary liver maligancies. The prognosis of liver angiosarcoma is very poor with almost all patients with this kind of disease die within 2 years after diagnosis. No specific symptoms and signs are closely associated with this disease. Here, we report a case presenting shock status at first due to rupture of liver angiosarcoma- induced internal bleeding. After emergent transarterial embolization (TAE), she received partial hepatectomy two weeks later. 4 months after operation, she is still with a good performance status without obvious recurrence or metastasis identified. (Source: World Journal of Surgical Oncology)

Intracranial hemorrhage in patients with cancer treated with bevacizumab: the Memorial Sloan-Kettering experience

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: ICH with bevacizumab treatment in this population is rare and does not appear to increase its frequency over the baseline rate of ICH in a comparable population. Most bevacizumab-related ICH occurs into central nervous system tumors but spontaneous hemorrhages were seen. (Source: Annals of Oncology)

Gemcitabine in advanced angiosarcoma: a retrospective case series analysis from the Italian Rare Cancer Network

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: Gemcitabine is active in both RT- and non-RT-related angiosarcoma, with dimensional and possibly long-lasting responses. A formal phase II study on gemcitabine as a single agent is warranted. (Source: Annals of Oncology)

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Metastatic angiosarcomas: doxorubicin-based regimens, weekly paclitaxel and metastasectomy significantly improve the outcome

Annals of Oncology — Tue, 24 Jan 2012 05:00:00 +0100

Conclusions: This retrospective analysis indicates that some therapeutic interventions may significantly improve the outcome of this aggressive disease. Doxorubicin-based regimens and weekly paclitaxel seem to provide the same range of efficacy. (Source: Annals of Oncology)

Spindle Cell Neoplasms Encountered in Dermatologic Surgery: A Review

Dermatologic Surgery — Mon, 23 Jan 2012 05:00:00 +0100

Cutaneous spindle cell tumors share the common feature of appearing as spindle‐shaped cells on light microscopy. Their pathogenesis, presentation, and prognosis are highly variable, and numerous techniques for workup and treatment have been reported. We performed an analysis of the available scientific literature in order to codify the clinical, immunohistochemical, and biologic features of these tumors and to provide insight into the most effective practices for their management, with a focus on Mohs micrographic surgery (MMS).In this article, the clinical and histopathological characteristics of dermatofibrosarcoma protuberans, atypical fibroxanthoma, malignant fibrous histiocytoma, spindle cell squamous cell carcinoma, superficial leiomyosarcoma, desmoplastic melanoma, cutaneous angio...

Molecular Mechanism of SFRP2 in Angiosarcoma and Development of SFRP2 Targeted Therapeutic

Journal of Surgical Research — Sat, 14 Jan 2012 22:28:56 +0100

(Source: Journal of Surgical Research)

Primary splenic angiosarcoma.

VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases — Sun, 01 Jan 2012 05:00:00 +0100

Authors: Liu Z, Du X, Li H, Wang Z, Shen Z, Yao Y, Zhao H Abstract Primary angiosarcoma of the spleen is a very rare but very aggressive soft tissue sarcoma due to early dissemination. The outcome of this disease is typically dismal with a mean survival of one to two years. However, our here presented case remained uncommonly symptom-free for nine years after splenectomy alone at the early phase of the disease. PMID: 22247061 [PubMed - in process] (Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases)

Primary cutaneous angiosarcoma of the breast after breast trauma.

Baylor University Medical Center Proceedings — Sun, 01 Jan 2012 05:00:00 +0100

We report a case of breast primary cutaneous angiosarcoma in a patient with a strong family history of malignancy. For definitive diagnosis, a tissue biopsy is needed, with immunostaining for the presence of blood vessel endothelial markers CD31 and CD34. Total mastectomy is the preferred method of surgical treatment. Chemotherapy has not been shown to increase overall survival, but in some instances it may improve local control and disease-free survival. Surgery combined with radiation may increase local control, but patients at high risk of recurrence may benefit from adjuvant treatment as well. We discuss the potential benefits from various treatments for primary cutaneous breast angiosarcoma. PMID: 22275789 [PubMed - in process] (Source: Baylor University Medical Center Proceedings...

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Primary and secondary angiosarcomas of the breast: a single institution experience

Breast Cancer Research and Treatment — Fri, 30 Dec 2011 07:08:45 +0100

Abstract Angiosarcomas of the breast (ASB) are rare, representing <1% of breast malignancies. They can develop as a primary or secondary malignancy, also called post-radiation angiosarcoma. The aim of the this study is to discuss diagnosis, treatment, and outcome of primary and secondary ASB patients, diagnosed and treated in a single institution, over a 10-year period and to further compare the two conditions. We retrieved 28 consecutive cases of ASB, diagnosed from 1999 to 2009 at the European Institute of Oncology. Clinical and pathologic findings and survival analyses were performed. Of the 28 cases (27 women and 1 man), eight were primary breast angiosarcomas (PBA) and 20 were secondary breast angiosarcomas (SBA). Median follow-up was 23 months (range 1–112&...

Primary pleural angiosarcoma as a mimicker of mesothelioma: a case report

Diagnostic Pathology — Fri, 30 Dec 2011 05:00:00 +0100

We report the case of a 49-year-old male patient with primary pleural angiosarcoma, who presented with initial hemothorax, followed by a rapid progress to an inoperable status. (Source: Diagnostic Pathology)

Angiosarcoma related to immunosuppressive therapy 8 years after renal transplantation.

Annals of Transplantation — Fri, 30 Dec 2011 05:00:00 +0100

Authors: Urün Y, Doğan I, Kiremitç S, Akbulut H, Içli F PMID: 22212232 [PubMed - in process] (Source: Annals of Transplantation)

Lymphangiosarcoma arising after 33 years within a background of chronic filariasis: a case report with review of literature

Journal of Cutaneous Pathology — Wed, 28 Dec 2011 21:28:50 +0100

We report a case of angiosarcoma arising after 33 years within a background of filariasis. Awareness of this association can lead to early diagnosis and appropriate treatment of this potentially fatal malignant tumor.Krishnamoorthy N, Viswanathan S, Rekhi B, Jambhekar NA. Lymphangiosarcoma arising after 33 years within a background of chronic filariasis: a case report with review of literature. (Source: Journal of Cutaneous Pathology)

Primitive Neuroectodermal Tumor of the Liver: A Case Report

Clinical and Developmental Immunology — Tue, 27 Dec 2011 23:55:03 +0100

Primary liver sarcomas represent a rare group of neoplasias, with angiosarcoma being the most common histological type. Primitive neuroectodermal tumor (PNET) represents a high malignant neoplasia that usually affects the central nervous system and soft tissues. An 18-year-old male patient was admitted with clinical complains of pain in the right upper abdominal quadrant. The clinical evaluation revealed a solid mass in the right hepatic lobe. On the gross examination of the resected liver specimen, the right lobe of the liver was replaced by a yellow-red solid mass measuring 21 cm in its largest dimension. On the histopathology, a tumor composed of small round blue cells with little cytoplasm and round nuclei was identified. The lesion revealed positive immunoexpression for vimenti...

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1. Post-radiation breast angiosarcoma: clinical and imaging findings to be known.

Cancer Imaging — Mon, 26 Dec 2011 17:24:03 +0100

Authors: Gerber S, Athanasiou A, Ala-Eddine C, Ollivier L, Neuenschwander S Abstract Secondary breast angiosarcomas are rare high-grade sarcomas that may complicate breast radiation. Their prevalence obviously increases with the increasing practice of breast-conservative therapy of breast cancer. The clinical manifestations, as slight modifications of the skin and palpable mass, are the first findings but may be mistaken and delay the diagnosis. The skin changes, such as discoloration or macules, may be the only sign and must be recognized. Mammography and ultrasonography findings are nonspecific most of the time. Magnetic resonance imaging (MRI) shows a lobular, intensely enhancing mass with rapid wash out, characteristic of a malignant lesion. The aim of this poster is to remind ...

Arsenic, vinyl chloride, viral hepatitis, and hepatic angiosarcoma: A hospital-based study and review of literature in Taiwan

BMC Gastroenterology — Mon, 26 Dec 2011 05:00:00 +0100

Conclusions: HAS is rare in Taiwan, and we found no evidence supporting a major role of VCM, arsenic in drinking water, or viral hepatitis in its occurrence. (Source: BMC Gastroenterology)

Doxorubicin and Paclitaxel Similar in Metastatic AngiosarcomaDoxorubicin and Paclitaxel Similar in Metastatic Angiosarcoma

Medscape Medical News Headlines — Fri, 23 Dec 2011 19:48:25 +0100

Paclitaxel and doxorubicin appear to have comparable efficacy in patients with metastatic angiosarcoma, researchers reported in Cancer. Reuters Health Information (Source: Medscape Medical News Headlines)

Doxorubicin and paclitaxel similar in metastatic angiosarcoma

Modern Medicine — Thu, 22 Dec 2011 05:00:00 +0100

NEW YORK (Reuters Health) - Paclitaxel and doxorubicin appear to have comparable efficacy in patients with metastatic angiosarcoma, researchers reported in Cancer. (Source: Modern Medicine)

High grade angiosarcoma arising in fibroadenoma

Diagnostic Pathology — Tue, 20 Dec 2011 05:00:00 +0100

Primary angiosarcoma of the breast is a rare tumour that account for fewer than 0.05% of all malignant mammary tumours. Angiosarcoma may have an perfidious clinical onset. Radiologic findings are often nonspecific and may appear completely normal in one-third of cases with primary angiosarcoma. The prognosis is usually poor because of the high rates of local recurrence and early development of metastases. Aggressive surgical resection is the mainstay of treatment. The role of adjuvant therapy has not yet been well established.Here we present a case of a 53 year old, postmenopausal women with primary angiosarcoma arising in fibroadenoma. To our knowledge, this is the first case described in the literature to date. (Source: Diagnostic Pathology)

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Angiosarcoma of the Prostate

The Journal of Urology — Mon, 19 Dec 2011 05:00:00 +0100

A 67-year-old man was diagnosed with adenocarcinoma of the prostate and received radiation therapy. He presented with urinary tract obstructive symptoms 7 years later and underwent transurethral resection of the prostate (TURP) followed by pelvic exenteration. (Source: The Journal of Urology)

Cardiac Angiosarcoma

Clinical and Developmental Immunology — Thu, 15 Dec 2011 23:54:25 +0100

We report a 21-year-old man with fever, dyspnea, and hemoptysis that was diagnosed with angiosarcoma of the right atrium and pulmonary metastasis. Patient was submitted to surgical tumor resection without adjuvant therapy and died four months after diagnosis. (Source: Clinical and Developmental Immunology)

A Case of Primary Angiosarcoma of the Lung Presenting as a Hemorrhagic Bronchial Tumor.

Annals of Thoracic and Cardiovascular Surgery — Fri, 09 Dec 2011 05:00:00 +0100

We report a case of primary angiosarcoma presenting as a hemorrhagic solitary nodule at the bifurcation of the left main bronchus, followed for two years before surgery. Bronchial arteriography revealed a tumor stain sign, and racemose hemangioma of the bronchial artery was excluded. The hemoptysis was not controlled by repeated bronchial artery embolization, and the patient underwent left pneumonectomy with routine mediastinal lymph node dissection. Histopathologically, the excised tissue revealed a highly-cellular growth of atypical spindle cells with a storiform pattern. These atypical cells showed relatively low mitotic activity; the MIB-1 index was 10%. The tumor was diagnosed as a primary angiosarcoma of the lung by the following immunohistological findings: positivity for factor VII...

Thoracic neoplasms at the Jena reference center for soft tissue tumors

Journal of Cancer Research and Clinical Oncology — Thu, 08 Dec 2011 18:22:06 +0100

Conclusions Our study provides information about the frequency, distribution, age and gender of patients with thoracic soft tissue tumors including several rare entities. Thus, it may help in the differential diagnosis of these neoplasms. In addition, we present a model highlighting the potential progression of lung carcinoma to undifferentiated sarcoma via the process of epithelial–mesenchymal transition. Content Type Journal ArticleCategory Original PaperPages 1-10DOI 10.1007/s00432-011-1108-8Authors Kathrin Nitsche, Institute of Pathology, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07740 Jena, GermanyBianka Günther, Institute of Pathology, Universitätsklinikum Jena, Ziegelmühlenweg 1, 07740 Jena, GermanyDetlef Katenkamp, Institute of Pathology, Univers...

Angiosarcoma of the mandibular gingiva.

International Journal of Clinical and Experimental Pathology — Thu, 08 Dec 2011 17:54:02 +0100

Authors: Terada T Abstract Angiosarcoma of the oral cavity is extremely rare. A 77-year-old woman consulted to our hospital because of polypoid mass of the mandibular gingival. Physical examination showed polypoid reddish mass measuring 1.5 × 1.5 × 1 cm in the mandibular gingival posterior to the front tooth. Enucleation of the tumor was performed. Grossly, the tumor was not encapsulated. Histologically, the tumor consisted of atypical spindle with hyperchromatic nuclei with nucleoli. Mitotic figures were scattered. Vasoformative channels were present in some areas. The surgical margins were positive. Immunohistochemically, the tumor cells were positive for factor VIII-related antigen, CD31, CD34, vimentin, p53 protein, but negative for pancytokeratin (AE1/3 and CAM5.2), S100 pro...

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Phase I study for ridaforolimus, an oral mTOR inhibitor, in Japanese patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology — Mon, 05 Dec 2011 17:33:57 +0100

Conclusions Ridaforolimus was well tolerated up to a dose of 40 mg in Japanese patients. Preliminary evidence of antitumor activity was observed for patients with solid tumors. Further investigation at this dose is warranted. Content Type Journal ArticleCategory Clinical Trial ReportPages 1-7DOI 10.1007/s00280-011-1788-4Authors Yoshitaka Seki, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanNoboru Yamamoto, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanYosuke Tamura, Division of Internal Medicine, National Cancer Center Hospital, Tsukiji 5-1-1, Chuo-ku, Tokyo 104-0045, JapanYasushi Goto, Division of Internal Medicine, National Cancer Center...

FISH for MYC amplification and anti‐MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations

Journal of Cutaneous Pathology — Thu, 01 Dec 2011 05:00:00 +0100

Conclusion: Amplification of MYC and nuclear expression of MYC is present in secondary angiosarcoma but not AVL. These ancillary tests can be useful to distinguish angiosarcoma from AVL in difficult cases.Fernandez AP, Sun Y, Tubbs RR, Goldblum JR, Billings SD. FISH for MYC amplification and anti‐MYC immunohistochemistry: useful diagnostic tools in the assessment of secondary angiosarcoma and atypical vascular proliferations. (Source: Journal of Cutaneous Pathology)

Angiosarcoma‐like presentation of pacemaker‐related vascular proliferation

Clinical And Experimental Dermatology — Fri, 25 Nov 2011 18:18:05 +0100

SummaryA 90‐year‐old man presented with a rapidly growing vascular lesion after a pacemaker generator change. The rapid growth suggested a possible angiosarcoma. A less dramatic presentation of vascular proliferation has been described as reticular telangiectatic erythema, which has been reporting following insertion of pacemakers, implantable cardioverter defibrillators, and drug‐delivery devices. The onset of the disorder is described as weeks to years after implantation or generator change. It is a benign condition that generally remains static or regresses over time. The vascular proliferation noted in this case resolved almost completely over a period of 1 year. (Source: Clinical And Experimental Dermatology)

A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features

Journal of Cutaneous Pathology — Tue, 22 Nov 2011 17:33:03 +0100

Vascular tumors are categorized into benign hemangiomas, frankly malignant angiosarcomas and tumors with intermediate biological behavior (hemangioendotheliomas). The latter group includes hemangioendotheliomas of the epithelioid, kaposiform, retiform and composite subtypes. Furthermore, a heterogeneous group of both benign and intermediate vascular tumors exhibits a peculiar hobnail cell morphology. This heterogeneous group encompasses hobnail hemangioma, retiform hemangioendothelioma, papillary intralymphatic angioendothelioma and a subset of angiosarcoma. We herein present a case of a cutaneous vascular neoplasm with hobnail morphology and unusual gross features.Wachter DL, Agaimy A. A cutaneous vascular neoplasm with hobnail microscopic morphology and unusual gross features. (Source: J...

Metastatic lung angiosarcoma from a femoral subperiosteal origin

Central European Journal of Medicine — Wed, 16 Nov 2011 06:47:32 +0100

We present a case of a 24-yearold woman with a subperiosteal diaphyseal angiosarcoma originating from the femoral bone and metastatic to the lung at the time of diagnosis. The clinical, histological and radiological features of this extremely rare lesion are presented. Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.2478/s11536-011-0118-xAuthors Evi Vassalou, Department of Medical Imaging, University Hospital, Heraklion, 711 10 GreeceEvangelos Perdikakis, Department of Medical Imaging, University Hospital, Heraklion, 711 10 GreeceElpida Giannikaki, Department of Pathology, University Hospital, Heraklion, 711 10 GreeceDimitris Mavroudis, Department of Medical Oncology, University Hospital, Heraklion, 711 10 GreecePavlos Katonis, Department of Othopaedics, University...

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Vascular Abnormalities of the Breast: Arterial and Venous Disorders, Vascular Masses, and Mimic Lesions with Radiologic-Pathologic Correlation [Breast Imaging]

Radiographics recent issues — Mon, 14 Nov 2011 05:00:00 +0100

Vascular abnormalities of the breast include a wide spectrum of arterial and venous disorders, as well as benign and malignant vascular masses. Multimodality imaging is often necessary to accurately diagnose several of these uncommon conditions, and pathologic correlation can be important for accurate diagnosis of vascular masses. After a review of the vascular anatomy of the breast, the authors discuss the imaging appearance of several native arterial disorders (atherosclerosis and aneurysm) and venous disorders (superior vena cava syndrome, congestive heart failure, thrombophlebitis, and varix). Benign vascular tumors (hemangioma, lymphangioma, and angiolipoma) and malignant vascular tumors (angiosarcoma and hemangiopericytoma) that may be encountered in the breast are also reviewed. In ...

Littoral Cell Angioma and Angiosarcoma of the Spleen: Report of Two Cases in Siblings and Review of the Literature

Journal of Gastrointestinal Surgery — Wed, 09 Nov 2011 07:03:57 +0100

Content Type Journal ArticleCategory Case ReportPages 1-5DOI 10.1007/s11605-011-1773-6Authors Michael Kranzfelder, Department of Surgery, RoMed Klinik Prien am Chiemsee, 83209 Prien am Chiemsee, GermanyMargit Bauer, Department of Surgery, RoMed Klinik Prien am Chiemsee, 83209 Prien am Chiemsee, GermanyThomas Richter, Pathology Rosenheim, 83022 Rosenheim, GermanyMartina Rudelius, Institute of Pathology, Klinikum rechts der Isar, TU München, 81675 Munich, GermanyMartin Huth, Department of Surgery, RoMed Klinik Prien am Chiemsee, 83209 Prien am Chiemsee, GermanyPeter Wagner, RoMed Klinikum Rosenheim, 83022 Rosenheim, GermanyHelmut Friess, Department of Surgery, Klinikum rechts der Isar, TU München, Ismaningerstrasse 22, 81675 Munich, GermanyJosef Stadler, Department of Surgery, RoMed Kl...

Spectrum of cardiac tumors excluding myxoma: Experience of a tertiary center with review of the literature.

Pathology, Research and Practice — Wed, 09 Nov 2011 05:00:00 +0100

Authors: Kumar N, Agarwal S, Ahuja A, Das P, Airon B, Ray R Abstract The aim of this study was to determine the histological spectrum of operated cardiac tumors, excluding myxoma, at a tertiary center in India. Between 1995 and 2010, we encountered 188 cases of operated cardiac tumors that had been subjected to histopathological examination. Morphological characterization was done by light microscopy along with histochemical stains. Immunohistochemistry using a panel of antibodies, i.e., vimentin, desmin, myogenin, smooth muscle actin (SMA), epithelial membrane antigen (EMA), cytokeratins, factor VIII-related antigen, S100-protein, synaptophysin, chromogranin, Bcl2, MIB-1, leukocyte common antigen (LCA), CD 3, CD20, CD34, and CD 99 (MIC-2) was performed wherever applicable. Out of ...

Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas

Cancer — Wed, 09 Nov 2011 00:29:22 +0100

CONCLUSIONS:First‐line single‐agent doxorubicin and weekly paclitaxel seem to have similar efficacy in metastatic angiosarcomas. Cutaneous angiosarcomas respond favorably to weekly paclitaxel. Best supportive care should be considered in patients with poor PS. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

Angiosarcoma: a study of 98 cases with immunohistochemical evaluation of TLE3, a recently described marker of potential taxane responsiveness

Journal of Cutaneous Pathology — Fri, 04 Nov 2011 02:36:30 +0100

Angiosarcomas may be primary in the skin, primary in soft tissue or viscera, or secondary to irradiation. All angiosarcomas have a poor prognosis. Taxanes may have efficacy in the treatment of angiosarcoma. Expression of TLE3 has been associated with improved outcome in taxane‐treated breast cancers. We studied a series of angiosarcoma with TLE3 immunohistochemistry. Cases of angiosarcoma (98 total cases; 37 cutaneous, 48 soft tissue/visceral and 13 post‐irradiation) were retrieved and follow up was obtained. Tumors were classified as ‘vasoformative’, ‘spindled’, ‘epithelioid’ and ‘mixed’. TLE3 immunohistochemistry was performed. Statistical analyses were performed. Patients (50 males and 48 females) had a median age of 60.2 years. Tumors had a median size 7.5 cm and we...

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Aberrant Melan‐A expression in atypical fibroxanthoma and undifferentiated pleomorphic sarcoma of the skin

Journal of Cutaneous Pathology — Fri, 04 Nov 2011 02:36:29 +0100

Conclusions: Aberrant expression of Melan‐A and MART‐1 in AFX and undifferentiated pleomorphic sarcoma of the skin represents an important diagnostic pitfall with potential for misdiagnosis as melanoma. Melan‐A expression limited to tumor giant cells, in the absence of S‐100 positivity, is a helpful diagnostic feature.Thum C, Hollowood K, Birch J, Goodlad JR, Brenn T. Aberrant Melan‐A expression in atypical fibroxanthoma and undifferentiated pleomorphic sarcoma of the skin. (Source: Journal of Cutaneous Pathology)

Primary adrenal angiosarcoma and functioning adrenocortical adenoma: an exceptional composite tumor.

European Journal of Endocrinology — Wed, 02 Nov 2011 04:00:00 +0100

Conclusion: To the best of our knowledge, this is the first case of an adrenal neoplasm combining a primary angiosarcoma and a functioning adrenocortical adenoma. PMID: 22048963 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)

p63 Immunohistochemical Staining Is Limited in Soft Tissue Tumors.

American Journal of Clinical Pathology — Tue, 01 Nov 2011 04:00:00 +0100

Authors: Jo VY, Fletcher CD Abstract p63 is a p53 homolog that is expressed in various normal epithelial tissues and epithelial malignancies. Its expression in mesenchymal lesions has not been examined in depth; therefore, we studied p63 expression by immunohistochemical analysis in 650 soft tissue tumors. We found that p63 expression is limited in soft tissue tumors. The majority of tumors studied were p63-, including all cases of angiosarcoma, lipomatous neoplasms, dermatofibrosarcoma protuberans, solitary fibrous tumor, schwannoma, neurofibroma, gastrointestinal stromal tumor, and leiomyosarcoma. Nuclear p63 reactivity was found in a subset of soft tissue myoepithelioma and myoepithelial carcinoma of soft tissue, cellular neurothekeoma, soft tissue perineurioma, Ewing sarcoma/pe...

Cardiac neoplasms and pseudotumors: imaging findings on multidetector CT angiography.

Diagnostic and Interventional Radiology : The Turkish Society of Radiology — Tue, 01 Nov 2011 04:00:00 +0100

This article reviews the MDCT features of the spectrum of cardiac neoplasms and pseudotumors and describes important diagnostic criteria. PMID: 22042729 [PubMed - as supplied by publisher] (Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology)

Magnetic resonance imaging of malignant soft tissue neoplasms in the adult.

Radiologic Clinics of North America — Fri, 28 Oct 2011 04:06:09 +0100

Authors: Walker EA, Salesky JS, Fenton ME, Murphey MD Abstract This review addresses the spectrum of malignant soft tissue tumors frequently found in adults. Rather than presenting a complete review, the focus of this discussion is on common lesions or lesions in which the diagnosis may be suggested on the basis of imaging. Diagnoses covered include undifferentiated high-grade pleomorphic sarcoma, fibrosarcoma, dermatofibrosarcoma protuberans, liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, clear cell sarcoma, hemangioendothelioma, hemangiopericytoma, angiosarcoma, and leiomyosarcoma. PMID: 22024296 [PubMed - in process] (Source: Radiologic Clinics of North America)

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Angiosarcoma Involving Native Abdominal Aortic Aneurysm Sac Following Endograft Repair

Journal of Vascular Surgery — Thu, 27 Oct 2011 11:45:46 +0100

Objectives: Angiosarcoma (AS) is a rapidly proliferating epithelioid tumor with high propensity for local recurrence and widespread metastases. This pathology presents challenges from the standpoints of diagnosis and treatment. (Source: Journal of Vascular Surgery)

Angiosarcoma Mimicking a Recurrent Carotid Artery Aneurysm

Annals of Vascular Surgery — Thu, 27 Oct 2011 11:40:48 +0100

Conclusion: From our study, we conclude that an unresolving or recurring aneurysm with equivocal radiological investigations should raise the suspicion of malignancy. (Source: Annals of Vascular Surgery)

Magnetic Resonance Imaging of Malignant Soft Tissue Neoplasms in the Adult

Radiologic Clinics of North America — Thu, 27 Oct 2011 08:56:33 +0100

This review addresses the spectrum of malignant soft tissue tumors frequently found in adults. Rather than presenting a complete review, the focus of this discussion is on common lesions or lesions in which the diagnosis may be suggested on the basis of imaging. Diagnoses covered include undifferentiated high-grade pleomorphic sarcoma, fibrosarcoma, dermatofibrosarcoma protuberans, liposarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, clear cell sarcoma, hemangioendothelioma, hemangiopericytoma, angiosarcoma, and leiomyosarcoma. (Source: Radiologic Clinics of North America)

3′‐deoxy‐3′‐[18F]fluorothymidine positron emission tomography for response assessment in soft tissue sarcoma

Cancer — Fri, 21 Oct 2011 04:00:00 +0100

CONCLUSIONS:Marked reductions in [18F]FLT tumor uptake in response to neoadjuvant treatment were observed in most patients with sarcoma. However, these reductions were not specific for histopathologic response to neoadjuvant therapy. Furthermore, posttreatment [18F]FLT tumor uptake was unrelated to tumor proliferation by Ki‐67 and TK1 staining. These results question the value of [18F]FLT PET imaging for treatment response assessments in patients with soft tissue sarcoma. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Pemphigus herpetiformis in a patient with well‐differentiated cutaneous angiosarcoma: Case report and review of the published work

The Journal of Dermatology — Tue, 18 Oct 2011 04:00:00 +0100

(Source: The Journal of Dermatology)

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Angiosarcoma of the liver with metastasis to the cervical spine cured with the treatment of thalidomide and radiotherapy

Acta Neurochirurgica — Thu, 13 Oct 2011 15:47:41 +0100

Content Type Journal ArticleCategory Letter to the EditorPages 1-2DOI 10.1007/s00701-011-1192-1Authors Selim Kayaci, Department of Neurosurgery, School of Medicine, Rize University, Rize, 53100 TurkeyOzcan Yildiz, Department of Oncology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, TurkeyHasan Gucer, Department of Pathology, School of Medicine, Rize University, Rize, TurkeyNil Molinas Mandel, Department of Oncology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey Journal Acta NeurochirurgicaOnline ISSN 0942-0940Print ISSN 0001-6268 (Source: Acta Neurochirurgica)

The clinical and functional outcome for patients with radiation‐induced soft tissue sarcoma

Cancer — Tue, 11 Oct 2011 04:00:00 +0100

CONCLUSIONS:Despite aggressive surgical treatment, patients who have RI‐STS remain at greater risk of both local and systemic recurrence compared with patients who have sporadic STS, but they can anticipate similar functional outcomes. Reirradiation can be relatively safe and effective if used properly. Cancer 2011. © 2011 American Cancer Society. (Source: Cancer)

Angiosarcoma Arising from the Tongue of an 11-Year-Old Girl with Xeroderma Pigmentosum

Head and Neck Pathology — Mon, 10 Oct 2011 15:05:15 +0100

Abstract Xeroderma pigmentosum (XP) is a rare autosomal recessive defect in DNA endonuclease activity that is associated with the development of cutaneous malignancies, at sun exposed sites, including basal cell carcinoma, squamous cell carcinoma, and melanoma. Squamous cell carcinomas are also known to target the anterior tongue. Patients sometimes develop angiosarcomas, and these invariably arise from sun-exposed skin. A biopsy was taken from a large mass arising in the anterior tongue of an 11-year-old girl with XP and a history of cutaneous basal cell carcinomas. The histopathologic findings demonstrated a high grade epithelioid neoplasm resembling a poorly differentiated squamous cell carcinoma, but the immunohistochemical profile (AE1/AE3 negative, p63 negative, CD31...

Sarcomas of Abdominal Organs: Computed Tomography and Magnetic Resonance Imaging Findings

Seminars in Ultrasound CT and MRI — Sat, 01 Oct 2011 04:00:00 +0100

This article aims to review the computed tomography and magnetic resonance imaging features of these rare tumors and to help in clinical diagnosis. Various sarcomas (eg, angiosarcoma, undifferentiated embryonal sarcoma, leiomyosarcoma, carcinosarcoma, rhabdomyosarcoma) originating, respectively, from different abdominal visceral organs (liver, pancreas, spleen, kidney, adrenal gland, uterus, and prostate gland) are reviewed along with cases we encountered. (Source: Seminars in Ultrasound CT and MRI)

Pathology of malignant skin tumours

Surgery (Medicine Publishing) — Sat, 01 Oct 2011 04:00:00 +0100

Abstract: The skin gives rise to a diverse spectrum of malignant tumours derived from the varied constituents of the epidermis and dermis. It is possible to discuss only a few of these in this article; the more common lesions derived from the epidermal keratinoctyes (basal and squamous cell carcinomas) together with melanomas (derived mainly from epidermal melanocytes) are presented. Some rarer but biologically aggressive tumours such as Merkel cell carcinoma and angiosarcoma are also discussed. Our understanding of the molecular biology of cutaneous tumours continues to evolve rapidly particularly for melanomas and in the coming years genetic profiling of individual tumours with targeted therapy is likely to play an important role in management. (Source: Surgery (Medicine Publishing))

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A fatal case of cutaneous multicentric epithelioid angiosarcoma

Journal of the American Academy of Dermatology — Sun, 18 Sep 2011 01:35:56 +0100

To the Editor: Multicentric epithelioid angiosarcoma (EA) involving the small bowel and distal part of the upper extremities has been reported but is rare in the skin. A 30-year-old woman noted two black painful nodules on her abdomen in May 2002, and soon another 10 lesions developed on her back, forearm, and chest in a month (). Initially, blue rubber bleb nevus was suspected. However, the nodules rapidly increased in number and size. The initial biopsy specimen revealed a well-circumscribed ectatic vascular structure lined by epithelioid endothelial cells with peripheral fibrous proliferation and thrombus formation (, A and B). Subsequent biopsies over the next 12 months showed a broad morphology spectrum of vascular anomalies from vascular malformation, spindle cell hemangioendothelio...

A case of angiosarcoma arising on a closed shunt in a patient with chronic renal failure

Journal of the American Academy of Dermatology — Sun, 18 Sep 2011 01:35:53 +0100

We report an angiosarcoma occurring on a closed shunt in the left forearm of a 49-year-old man requiring hemodialysis for high-grade chronic renal failure over 23 years. As the shunt previously constructed for hemodialysis in the left forearm had been thrombosed, a new shunt was constructed in the right forearm in 2006. A rapidly growing tumor was noted in the nonfunctioning shunt in 2007. By skin biopsy, a diagnosis of angiosarcoma was made at the local hospital and he was referred to our hospital for treatment in 2008. A dark red dome-shaped tumor 33 × 31 mm in diameter with bleeding tendency was observed (). Blood tests revealed severe renal failure and anemia: blood urea nitrogen 47 mg/dL, creatinine 9.12 mg/dL, potassium 5.7 mg/dL, and red blood cell count 29×103/mL. Serological t...

Rapidly Progressive Lung Cysts and Pleural Effusion: A Case Report

Diagnostic and Therapeutic Endoscopy — Sat, 10 Sep 2011 22:28:57 +0100

Angiosarcoma is a rare but highly malignant tumor arising from vascular endothelial cells. Angiosarcoma commonly arises from the heart, liver, breast, and skin including the scalp. Angiosarcoma metastasizing to the lungs can present as either pneumothorax, hemothorax, or pleural effusions. They can rarely present as rapidly enlarging thin-walled pulmonary cysts. A review of the literature is included. (Source: Diagnostic and Therapeutic Endoscopy)

Postradiation cutaneous angiosarcoma after treatment of breast carcinoma is characterized by MYC amplification in contrast to atypical vascular lesions after radiotherapy and control cases: clinicopathological, immunohistochemical and molecular analysis of 66 cases

Modern Pathology AOP — Fri, 09 Sep 2011 04:00:00 +0100

Authors: T Mentzel, H U Schildhaus, G Palmedo, R Büttner & H Kutzner (Source: Modern Pathology AOP)

Spindle Cell Hemangioendothelioma of the Temporal Muscle Resected with Zygomatic Osteotomy: A Case Report of an Unusual Intramuscular Lesion Mimicking Sarcoma

Clinical and Developmental Immunology — Tue, 06 Sep 2011 15:07:31 +0100

Spindle cell hemangioendothelioma (SCH) was originally described by Weiss and Enzinger (1986) as a low-grade angiosarcoma resembling both cavernous hemangioma and Kaposi's sarcoma. Recent studies suggest that SCH is a benign neoplasm or reactive lesion accompanying a congenital or acquired vascular malformation. Most SCHs present as one or more nodules affecting the dermis or subcutis of the distal extremities. Few reports describe SCH of the head and neck region; even fewer note intramuscular SCH. Here, we describe a case of SCH involving the temporal muscle mimicking soft tissue sarcoma, who had a successful surgical treatment with a coronal approach and zygomatic osteotomy. (Source: Clinical and Developmental Immunology)

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Large Clinical Experience of Primary Angiosarcoma of the Breast in a Single Korean Medical Institute

World Journal of Surgery — Thu, 01 Sep 2011 06:11:41 +0100

Conclusions Primary angiosarcoma of the breast is a rare malignancy with a poor prognosis, even with complete resection. Chemotherapy and radiation therapy have limited value as treatments to date. Total mastectomy appears to be the most appropriate and beneficial treatment. More aggressive surgical management should be considered, and future clinical research should explore the most appropriate adjuvant therapy in the treatment of angiosarcoma. Content Type Journal ArticlePages 1-5DOI 10.1007/s00268-011-1225-1Authors Soo Youn Bae, Department of Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, 143-729 Republic of KoreaMin-Young Choi, Department of Surgery, Samsung Medical Center, Sungkyunkwan Un...

Angiosarcoma of sigmoid colon with intraperitoneal bleeding: case report and literature review.

Annals of the Royal College of Surgeons of England — Thu, 01 Sep 2011 04:00:00 +0100

We report a case of an angiosarcoma of the sigmoid colon with intraperitoneal bleeding but not rectal bleeding. A 21-year-old female patient received a laparotomy and a mass lesion over the sigmoid colon was found with active bleeding. A sigmoid colectomy was performed as a curative resection. Grossly, the sigmoid colon contained a kidney shaped, hemorrhagic tumour from the submucosal layer extension to the antimesenteric side. Intraluminally, the mucosa of the colon was intact. Microscopic examination revealed a high grade angiosarcoma composed of fascicles of spindle cells and solid sheets of epithelioid cells. Immunohistochemical stains revealed a positive result for CD31 and the endothelial nature of the malignancy was confirmed. Smooth muscle antigens, desmins, cytokeratins AE1/AE3 an...

Anastomosing hemangioma of the genitourinary system: eight cases in the kidney and ovary with immunohistochemical and ultrastructural analysis.

American Journal of Clinical Pathology — Mon, 22 Aug 2011 21:44:16 +0100

We describe 3 ovarian and 5 renal anastomosing hemangiomas. One manifested with polycythemia, others were incidental; none recurred. The mean patient age was 58 years. Three hemangiomas developed in end-stage renal disease. Tumors were well-demarcated, mahogany brown, spongy lesions measuring 0.1 to 5 cm. Tortuous large vessels fed and drained tightly packed anastomosing sinusoidal capillary channels. Four hemangiomas exhibited lobular architecture, central edema/hyalinization, and intravascular growth. Five cases had thrombosis, hemorrhage, and hemosiderin. One ovarian tumor induced stromal luteinization. Three tumors had foci of extramedullary hematopoiesis (one associated with polycythemia). Six cases demonstrated eosinophilic intracytoplasmic globules. Three cases included hobnail endo...

Angiosarcoma of the breast

QJM — Thu, 18 Aug 2011 23:00:00 +0100

(Source: QJM)

Primary vascular tumors of bone: a spectrum of entities?

International Journal of Clinical and Experimental Pathology — Mon, 15 Aug 2011 04:00:00 +0100

Authors: Verbeke SLj, Bovée JV Abstract Vascular tumors of bone are a heterogeneous group. Numerous terms have been introduced as well as different classification systems. None of the classification schemes have been accepted due to lack of consistent terminology, accepted histologic criteria, and limited correlation with clinical outcome. It is acknowledged that vascular tumors of bone originate from endothelial cells, resulting in variable expression of endothelial markers. None of these markers are useful to discriminate between benign and malignant lesions. Although radiologic appearance is not specific, radiologic multifocality should trigger to include a vascular neoplasm in the differential diagnosis. This review gives an overview of current literature by describing all dif...

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Liver hemangiomas and elevated serum α-fetoprotein: unsolved questions—reply

Human Pathology — Fri, 12 Aug 2011 23:56:09 +0100

Thank you for allowing us the opportunity to respond to the letter to the editor submitted by Bell et al in response to our article in this journal. We appreciate and agree with the points regarding the view that use of the term liver hemangioma minimizes the chance of confusion with other adult endothelial tumors more so than does our use of “infantile hemagioendothelioma (IHE)”of the liver . IHE was adopted in the World Health Organization (WHO) classification of tumors in 2000 . “Hemangioma of infancy” has been adopted by the WHO for the skin , whereas IHE has been reserved for the liver because of the presence of histologically more aggressive type of IHE and occasional reports of transformation of hepatic IHE to angiosarcoma . However, the terminology and concept of this enti...

Kaposi Sarcoma of the Adrenal Gland Resembling Epithelioid Angiosarcoma: A Case Report

Computational Intelligence and Neuroscience — Tue, 09 Aug 2011 14:20:59 +0100

We report herein a 64-year-old man with a long-standing history of human immunodeficiency virus infection who developed a right adrenal tumor with a high-grade anaplastic angiosarcoma-like morphology. Immunohistochemistry for human herpes virus-8 was strongly positive in the tumor cells. To the best of our knowledge, this is the first report of an anaplastic Kaposi sarcoma in the adrenal gland. (Source: Computational Intelligence and Neuroscience)

Hepatic angiosarcoma: an analysis of 7 cases

The Chinese-German Journal of Clinical Oncology — Mon, 08 Aug 2011 19:59:18 +0100

Conclusion Hepatic angiosarcoma is a rare and difficult-to-diagnose malignant liver tumor. Surgery is the definitive treatment and adjuvant chemotherapy after surgery may improve survival. Content Type Journal ArticlePages 484-486DOI 10.1007/s10330-011-0818-3Authors Dongzhi Yin, Huangshi Center Hospital, Huangshi, 435000 ChinaQichang Zheng, Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 ChinaYouneng Yuan, Huangshi Center Hospital, Huangshi, 435000 China Journal The Chinese-German Journal of Clinical OncologyOnline ISSN 1613-9089Print ISSN 1610-1979 Journal Volume Volume 10 Journal Issue Volume 10, Number 8 (Source: The Chinese-German Journal of Clinical Oncology)

[High-grade small bowel angiosarcoma associated with angiosarcomatosis: A case report].

Annales de Pathologie — Sun, 31 Jul 2011 23:00:00 +0100

We report a case of a 25-year-old woman who presented with a small intestinal angiosarcoma associated with angiosarcomatosis. The diagnosis was established on surgical intestinal resection, that showed a high-grade angiosarcoma with epithelioid component and foci of agressive form of hemangioendothelioma. Immunohistochemical study revealed tumour cell positivity with endothelial markers CD31 and factor VIII whereas CD34 and epithelial markers were negative. The tumour displayed KIT (CD117) immunoreactivity without KIT or PDGFRA mutation on molecular analysis. Clinical and pathological features as well as differential diagnosis of this rare entity in gastrointestinal tract are discussed. PMID: 21839357 [PubMed - in process] (Source: Annales de Pathologie)

[Vascular tumors and pseudo-tumors. Well-differentiated angiosarcoma].

Annales de Pathologie — Sun, 31 Jul 2011 23:00:00 +0100

Authors: Guinebretière JM PMID: 21839352 [PubMed - in process] (Source: Annales de Pathologie)

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Angiosarcoma with Tingible Body Macrophages

Journal of Cutaneous Pathology — Wed, 27 Jul 2011 05:18:04 +0100

(Source: Journal of Cutaneous Pathology)

Angiosarcoma in an obese woman with worsening lymphedema after weight-loss and skin-reduction surgeries

Journal of the American Academy of Dermatology — Sat, 16 Jul 2011 16:19:58 +0100

To the Editor: Cutaneous angiosarcomas are rare, aggressive tumors that comprise approximately 2% of all soft tissue sarcomas. Their overall prognosis is very poor, with a 5-year survival rate ranging from 10% to 35%. Epithelioid angiosarcoma is a rare variant of cutaneous angiosarcoma that can have equally aggressive behavior. The development of cutaneous angiosarcoma may be a rare, but significant, possible side effect of the lymphedema associated with both obesity and weight loss or skin reduction surgery. (Source: Journal of the American Academy of Dermatology)

Primary angiosarcoma of the ovary with prominent fibrosis of the ovarian stroma. Case report of an 81-year old patient.

Diagnostic Pathology — Wed, 13 Jul 2011 23:00:00 +0100

ABSTRACT. Primary angiosarcoma of the ovary (AS) is a rare entity with only 31 reported cases. The majority are pure angiosarcomas, the remainder are associated either with teratomas or conventional epithelial tumors. More than 50% of ovarian AS are disseminated at the time of diagnosis, the minority is detected in stage I. The prognosis of ovarian angiosarcoma in general is poor. Most reports refer to younger individuals, aged from 7 to 46 years, and only 2 case reports could be found for patients older than 64 years. Here we present a very unusual case of angiosarcoma in a 81-year-old patient. (Source: Diagnostic Pathology)

Radically resected epithelioid angiosarcoma that originated in the mediastinum

General Thoracic and Cardiovascular Surgery — Wed, 13 Jul 2011 05:57:33 +0100

We report on the surgical resection of a rare case of giant epithelioid angiosarcoma originating in the anterior mediastinum, followed by six courses of adjuvant chemotherapy (doxorubicin + ifosfamide). The patient is alive and asymptomatic 1 year after surgery. As the prognosis for unresectable cases is generally dismal, surgical resection and adjuvant therapy can be an option for mediastinal angiosarcoma. Content Type Journal ArticlePages 503-506DOI 10.1007/s11748-010-0710-zAuthors Shinya Tane, Department of Thoracic Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558 JapanYugo Tanaka, Department of Thoracic Surgery, Hyogo Cancer Center, 13-70 Kitaouji-cho, Akashi, 673-8558 JapanSyunsuke Tauchi, Department of Thoracic Surgery, Hyogo Cancer Center, 13-70 Kitaouji...

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Primary Breast Angiosarcoma: Avoiding a Common Trap

Infectious Diseases in Obstetrics and Gynecology — Thu, 07 Jul 2011 15:54:48 +0100

Conclusion. Primary breast angiosarcoma is a rare entity often difficult to diagnose on core biopsy, and a benign differential diagnosis is frequent. A highly vascular breast mass should always be considered malignant until proven otherwise. Surgical treatment seems to be the best course of action. There is a lack of data proving efficacy of adjuvant chemotherapy and radiation therapy. (Source: Infectious Diseases in Obstetrics and Gynecology)

Epithelioid Angiosarcoma With Metastatic Disease After Endovascular Therapy of Abdominal Aortic Aneurysm

CardioVascular and Interventional Radiology — Thu, 07 Jul 2011 05:46:15 +0100

We report a patient with epithelioid angiosarcoma and metastatic disease, which was found in an aneurysmal sac after endovascular aortic repair for abdominal aortic aneurysm. Content Type Journal ArticlePages 1-4DOI 10.1007/s00270-011-0219-6Authors Jörg Schmehl, Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, 72076 Tuebingen, GermanyMarcus Scharpf, Institute of Pathology and Neuropathology, University Hospital of Tuebingen, 72076 Tuebingen, GermanyKlaus Brechtel, Department of Diagnostic and Interventional Radiology, University Hospital of Tuebingen, 72076 Tuebingen, GermanyGünay Kalender, Department of Thoracic and Cardiovascular Surgery, University Hospital of Tuebingen, 72076 Tuebingen, GermanyStephan Heller, Department of Diagnostic an...

Prinzmetal's angina in a patient with angiosarcoma of the right cardiac chambers

Heart and Lung — Thu, 30 Jun 2011 23:00:00 +0100

We describe a classic case of variant angina associated with an angiosarcoma of the right heart chambers. (Source: Heart and Lung)

Reirradiation and hyperthermia for radiation‐associated sarcoma

Cancer — Mon, 27 Jun 2011 23:00:00 +0100

CONCLUSIONS:The current study indicates that combined reirradiation and hyperthermia for RAS in the thoracic region is feasible. The high response rate and the possibility of durable local control suggest that this treatment is promising. Cancer 2011;. © 2011 American Cancer Society. (Source: Cancer)

A Triple-Targeted Ultrasound Contrast Agent Provides Improved Localization to Tumor Vasculature

Journal of Ultrasound in Medicine — Thu, 23 Jun 2011 23:00:00 +0100

Conclusions— Microbubble accumulation in the tumor vasculature was improved using a triple-targeted microbubble approach. (Source: Journal of Ultrasound in Medicine)

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Epithelioid angiosarcoma of the kidney: A diagnostic dilemma in fine‐needle aspiration cytology

Diagnostic Cytopathology — Tue, 21 Jun 2011 23:00:00 +0100

We report the fine‐needle aspiration (FNA) cytology findings of a case of EAS that involved the left kidney of an 83‐year‐old male. The smears and cell block sections showed pleomorphic epithelioid cells with ample cytoplasm, eccentric nuclei, occasional cytoplasmic hyaline globules, and rare intracytoplasmic lumina. Immunohistochemical stains performed on cellblock sections showed that the tumor cells were positive for vimentin, CD31, CD34, Factor VIII, and CD10, but showed no staining for cytokeratins AE1/AE3 and 8/18, HMB45, CD45, smooth muscle actin, and S100. The morphological and immunohistochemical distinction between EAS, primary tumors of the kidney, and other epithelioid and rhabdoid neoplasms is discussed. Diagn. Cytopathol. 2011; © 2011 Wiley‐Liss, Inc. (Source: Diagno...

Retiform hemangioendothelioma treated with Mohs micrographic surgery

Journal of the American Academy of Dermatology — Sat, 18 Jun 2011 16:31:44 +0100

We report a case of retiform hemangioendothelioma treated with MMS. (Source: Journal of the American Academy of Dermatology)

PML expression in soft tissue sarcoma: Prognostic and predictive value in alkylating agents/antracycline‐based first line therapy

Journal of Cellular Physiology — Tue, 14 Jun 2011 23:00:00 +0100

Conclusions:PML IHC expression is downregulated in synovial sarcomas, myofibroblastic sarcomas, angiosarcomas, liposarcoma and leiomyosarcomas and its expression correlated with prognosis. J. Cell. Physiol. © 2011 Wiley‐Liss, Inc. (Source: Journal of Cellular Physiology)

High-Grade Breast Epithelioid Angiosarcoma Secondary to Radiotherapy Metastasizing to the Contralateral Lymph Node: Unusual Presentation and Potential Pitfall

Breast Care : Last 20 articles — Mon, 13 Jun 2011 23:00:00 +0100

Breast Care 2011;6:227–229 (DOI:10.1159/000329323) (Source: Breast Care : Last 20 articles)

Occasional Staining for p63 in Malignant Vascular Tumors: A Potential Diagnostic Pitfall.

Pathology Oncology Research — Sun, 12 Jun 2011 23:00:00 +0100

Authors: Kallen ME, Nunes Rosado FG, Gonzalez AL, Sanders ME, Cates JM Expression of p63, a putative marker for epithelial or myoepithelial differentiation, has been used to distinguish spindle cell carcinoma from sarcoma. The specificity of p63 for epithelial differentiation has not been thoroughly evaluated however, since p63 expression has been explored in only a handful of mesenchymal tumors. After observing unexpected immunohistochemical staining for p63 in an angiosarcoma of the breast, we evaluated a series of benign and malignant vascular tumors to determine the frequency of such a finding. Nuclear immunoreactivity to p63 was detected, at least focally, in 24% of malignant vascular tumors other than Kaposi sarcoma, which was uniformly negative. Benign vascular tumors were also ...

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Selected Case From the Arkadi M. Rywlin International Pathology Slide Seminar: Injection-Site High-Grade Angiosarcoma, Subcutis, Left Buttock Region

Advances in Anatomic Pathology — Fri, 10 Jun 2011 21:13:52 +0100

A high-grade angiosarcoma with epithelioid features located in the buttock of an 87-year-old woman arose in an area of old, palpable fat necrosis at the site of several subcutaneous injections administered 20 years previously. The nature of the injected material is unknown, but is presumed to have been an iron compound. Two weeks before surgery, the buttock lesion started to enlarge and was excised. It consisted of 3 contiguous nodules of old, calcified fat necrosis associated with plentiful hemosiderin. One of the nodules was largely replaced by an angiosarcoma, which was invading the edges of the other 2 nodules. The patient died from wound sepsis 41 days postoperatively, with no clinically apparent metastases. Vaccination injection-site sarcomas are well known to occur in cats, whereas ...

Surgical management of radiation-induced angiosarcoma after breast conservation therapy

American Journal of Surgery — Fri, 10 Jun 2011 04:00:00 +0100

Conclusions: RA is a challenging condition, with a prolonged latency period and variable clinical progression. Incomplete excision of RA is a surrogate marker of aggressive disease and is associated with rapid LR and poor survival. (Source: American Journal of Surgery)

Malignancies Confined to Disused Arteriovenous Fistulae in Renal Transplant Patients: An Important Differential Diagnosis.

American Journal of Nephrology — Thu, 09 Jun 2011 23:00:00 +0100

Conclusion: Malignancy at an AVF is a rare but important differential that can impact significantly on patient morbidity and mortality. Predilection for malignancy at an AVF is not understood. We review the literature and discuss possible aetiologies. PMID: 21659738 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)

Primary multifocal angiosarcoma of the pleura [Case report - Thoracic oncologic]

Interactive CardioVascular and Thoracic Surgery — Tue, 07 Jun 2011 23:00:00 +0100

We present the case of a patient who had a primary multifocal angiosarcoma of the pleura with left-sided chest pain. (Source: Interactive CardioVascular and Thoracic Surgery)

Multifocal Epithelioid Hemangioma with Reactive Bone Formation

Diagnostic and Therapeutic Endoscopy — Mon, 06 Jun 2011 14:54:08 +0100

A healthy 16-year-old male patient presented with several weeks of right ankle pain on weight-bearing, worsened with sporting activities, and relieved with rest. Radiographs demonstrated multiple well-marginated lytic lesions in the right distal tibia, and talar head and neck, with a further small intracortical lesion in the mid-to-distal anterior tibia. MRI showed multiple rounded low T1 and high T2 signal intensity lesions within the distal tibia and talus, with marked associated bone marrow edema. The radiologic diagnoses included multifocal hemangioendothelioma, multifocal hemangioma, angiosarcoma, atypical infection, Langerhans cell histiocytosis, or osteoblastomatosis. Histology showed sheets of epithelioid cells lining vascular structures in a hobnailed “tombstone-like” ...

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A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas

Carcinogenesis — Wed, 01 Jun 2011 23:00:00 +0100

Exposure to ionizing radiation is a known risk factor for cancer. However, up to now, rigorously defined scientific criteria that could establish case-by-case the radiation-induced (RI) origin of a tumour have been lacking. To identify genes that could constitute a RI signature, we compared the transcriptome of 12 sarcomas arising in the irradiation field of a primary tumour following radiotherapy with the transcriptome of 12 sporadic sarcomas. This learning/training set contained four leiomyosarcomas, four osteosarcomas and four angiosarcomas in each subgroup. We identified a signature of 135 genes discriminating RI from sporadic sarcomas. The robustness of this signature was tested by the blind case-by-case classification of an independent set of 36 sarcomas of various histologies. Thirt...

Magnetic Resonance Imaging of Cardiac Tumors: Part 2, Malignant Tumors and Tumor-Like Conditions

Current Problems in Diagnostic Radiology — Wed, 25 May 2011 18:09:06 +0100

Cardiovascular magnetic resonance imaging (CMRI) is the reference noninvasive imaging technique for assessment and characterization of a suspected cardiac or juxta-cardiac mass. The multiplanar assessment of anatomy, tissue composition, and functional impact afforded by CMRI allows for early differentiation between a nonneoplastic mass and a tumor mass, be it benign or malignant. Malignant cardiac tumors have a poor prognosis; however, early detection and characterization confer some survival advantage, enabling early instigation of chemotherapy and/or consideration of a surgical debulking procedure. Cardiac metastases are far more common than primary tumors and are an important consideration in patients with disseminated disease. Angiosarcoma accounts for the majority of primary malignant...

Testing new regimens in patients with advanced soft tissue sarcoma: analysis of publications from the last 10 years

Annals of Oncology — Mon, 23 May 2011 23:00:00 +0100

Conclusions: In the past 10 years, several drugs or combinations have demonstrated promising activity in exploratory phase II trials and warrant further investigation in appropriate phase III trials. (Source: Annals of Oncology)

Cardiac Angiosarcoma-Associated Membranoproliferative Glomerulonephropathy

Journal of Oncology — Wed, 18 May 2011 15:04:46 +0100

We present a patient who presented with a hemorrhagic pericardial effusion. No malignant cells were evident on cytological examination. He subsequently developed membranoproliferative glomerulonephritis requiring hemodialysis. Metastatic cardiac angiosarcoma was diagnosed 5 months later. To our knowledge, this is the first reported case of paraneoplastic membranoproliferative glomerulopathy associated with cardiac angiosarcoma. (Source: Journal of Oncology)

A novel WWTR1‐CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites

Genes, Chromosomes and Cancer — Sun, 15 May 2011 23:00:00 +0100

AbstractThe classification of epithelioid vascular tumors remains challenging, as there is considerable morphological overlap between tumor subtypes, across the spectrum from benign to malignant categories. A t(1;3)(p36.3;q25) translocation was reported in two cases of epithelioid hemangioendothelioma (EHE), however, no follow‐up studies have been performed to identify the gene fusion or to assess its prevalence in a larger cohort of patients. We undertook a systematic molecular analysis of 17 EHE, characterized by classic morphological and immunophenotypic features, from various anatomical locations and with different malignant potential. For comparison, we analyzed 13 epithelioid hemangiomas, five epithelioid angiosarcomas, and four epithelioid sarcoma‐like EHE. A fluorescence in sit...

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Echocardiography in differential diagnosis of chest pain and elevated cardiac biomarkers: a case of cardiac angiosarcoma

European Journal of Echocardiography — Sun, 08 May 2011 23:00:00 +0100

In this report, we describe a 28-year-old male patient presenting with symptoms and findings of myocardial ischaemia who has been finally diagnosed with cardiac angiosarcoma. (Source: European Journal of Echocardiography)

Angiosarcoma of the trunk of unusual presentation in an immuno-competent man

Indian Journal of Dermatology — Wed, 04 May 2011 23:00:00 +0100

Amel Mebazaa, Amina Aounallah, Monia Tangour, Hela Moula, Dalenda El Euch, Slim Haouet, Mourad Mokni, Moncef Zitouna, Amel Ben OsmanIndian Journal of Dermatology 2011 56(2):233-234 (Source: Indian Journal of Dermatology)

Clinical Patterns and Outcome in Epithelioid Hemangioendothelioma With or Without Pulmonary Involvement: Insights from an Internet Registry in the Study of a Rare Cancer.

Chest — Wed, 04 May 2011 23:00:00 +0100

CONCLUSIONS: A novel staging system with prognostic value for EHE is proposed. Pleural effusion or other signs of uncontained tumor growth, hemoptysis, osseous involvement of more than two bones, implied worse survival than did localized and discrete tumors, regardless of number of organs involved. A lay registry can provide useful insights into the clinical behavior of a rare cancer. PMID: 21546438 [PubMed - as supplied by publisher] (Source: Chest)

Clinicopathologic and immunohistochemical characteristics of adult primary cardiac angiosarcomas: analysis of 10 cases

Annals of Diagnostic Pathology — Wed, 04 May 2011 23:00:00 +0100

The objective of this study is to analyze the clinicopathologic characteristics of primary cardiac angiosarcoma. Ten cases of primary cardiac angiosarcoma treated in a single institution were analyzed for their clinical, pathologic, and immunohistochemical features. There were 6 men and 4 women, with a mean age of 40 years (range, 20-61 years). The patients commonly presented with dyspnea and distant metastasis. All tumors were located in the right atrium, with a mean tumor size of 6.8 cm. Tumors were hemorrhagic, with variegated tan-brown solid areas. Histologically, they exhibited high-grade morphology with mixed solid growth and anatomizing channels. Frequent mitoses and tumor necrosis were common. The tumors were strongly positive for CD31, CD34, FLI-1, and WT-1 but negative for AE1/3,...

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Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature

Clinical and Developmental Immunology — Mon, 02 May 2011 13:58:40 +0100

Angiosarcoma (AS) is a rare and aggressive vascular neoplasm with very poor prognosis. Patients with extensive cutaneous AS who are not surgical candidates have very limited options since there is no standard treatment. Treatment options include radiation, chemotherapy, and angiogenesis inhibitor with varying success rates. Here, we report a case an 88 year old patient with extensive scalp angiosarcoma having biopsy proven remission with bevacizumab and radiotherapy without undergoing surgery. (Source: Clinical and Developmental Immunology)

Primary cardiac angiosarcoma treated by complete tumor resection with cardiac reconstruction

Heart and Lung — Sat, 30 Apr 2011 23:00:00 +0100

We report a case of right atrial angiosarcoma treated by complete tumor resection with cardiac reconstruction with a bovine pericardium patch. (Source: Heart and Lung)

A Rare Case of CD30+, Radiation-Induced Cutaneous Angiosarcoma Misdiagnosed As T-Cell Lymphoma [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Thu, 28 Apr 2011 23:00:00 +0100

(Source: Journal of Clinical Oncology)

Cutaneous angiosarcoma arising in massive localized lymphedema of the morbidly obese: a report of five cases and review of the literature

Journal of Cutaneous Pathology — Mon, 25 Apr 2011 23:00:00 +0100

A significant proportion of angiosarcoma arises in the setting of chronic lymphedema, often following surgery for breast carcinoma (Stewart–Treves syndrome). Massive localized lymphedema (MLL), a relatively recently described and rare pseudotumor most often occurring in morbidly obese patients, is thought to be the result of derangements in lymphatic drainage secondary to excessive adipose tissue. Only a very small number of cases of angiosarcoma have been reported in patients with MLL. We reviewed the clinical and pathological features of five patients with angiosarcoma arising in this unusual clinical setting. The tumors arose in three women and two men, who were in the age range from 36 to 81 years (median: 52 years). All patients were or had recently been morbidly obese (mean body ma...

Stewart–Treves Syndrome and the Use of Positron Emission Tomographic Scanning

Annals of Vascular Surgery — Wed, 20 Apr 2011 23:00:00 +0100

In this article, we provide an account of two rare cases of Stewart–Treves syndrome, that is, cutaneous angiosarcoma secondary to lymphedema, treated at our center. Unusually, both occurred in the lower extremity. The first case was treated initially with a wide local excision, followed by a further re-excision, and eventually an above-the-knee amputation because of recurrence. In the second case, a hindquarter amputation was undertaken after a positron emission tomographic scan, which revealed the extent and spread of the lesions. In cases of cutaneous angiosarcoma, a positron emission tomographic scan can be extremely helpful in demonstrating the extent of subcutaneous spread and planning surgical management. (Source: Annals of Vascular Surgery)

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Angiosarcoma mimicking cutis verticis gyrata

Clinical And Experimental Dermatology — Tue, 19 Apr 2011 23:00:00 +0100

(Source: Clinical And Experimental Dermatology)

Pleural cavity angiosarcoma arising in chronic expanding hematoma after pneumonectomy

Human Pathology — Mon, 18 Apr 2011 04:00:00 +0100

Summary: A 52-year-old man received a left pneumonectomy for pulmonary squamous cell carcinoma without signs of recurrence after surgery. At age 68 years, a capsulated huge mass developed in the left pleural cavity, which was diagnosed as chronic expanding hematoma. Two years and 8 months after detection, the lesion began to invade the chest wall, and 10 months later, the patient died of active bleeding and direct compression of the heart by the lesion. At autopsy, the left thoracic cavity was occupied by a cystic and hemorrhagic mass infiltrating into the surrounding structures. In addition, scattered tumorous nodules were observed in the right lung. Histologically, angiosarcoma with irregularly anastomosing vessels lined with atypical endothelial cells was noted in the chronic expanding ...

Angiosarcoma of the ovary arising in a mucinous cystadenoma

Journal of Clinical Ultrasound — Sat, 16 Apr 2011 00:16:39 +0100

We report the case of a 39‐year‐old woman who presented with a pelvic mass extending into the upper abdomen. Transabdominal sonography revealed a complex left adnexal mass. Color Doppler imaging and spectral Doppler analysis showed increased vascularity with low impedance blood flow signals, suggestive of neovascularization. The patient underwent a laparotomy and a 56‐kg predominantly cystic tumor was removed from the left adnexal region. The patient died 3 months later with pulmonary metastases and massive pulmonary hemorrhage. Postmortem resampling of the ovarian tumor initially diagnosed as mucinous cystadenoma showed nodular areas of malignant pleomorphic cells consistent with angiosarcoma. © 2011 Wiley Periodicals, Inc. J Clin Ultrasound, 2011; (Source: Journal of Clinical Ultr...

Successful Surgical Excision of Primary Right Atrial Angiosarcoma.

BioMed Central — Fri, 08 Apr 2011 23:00:00 +0100

We report the case of a 50-year old Caucasian woman with non-metastatic primary right atrial angiosarcoma, who underwent successful surgical excision of the tumor (with curative intent) and reconstruction of the right atrium with a porcine pericardial patch. However, after a symptom-free survival of five months the patient presented with bone and liver metastases without evidence of local tumor recurrence. (Source: BioMed Central)

Primary adrenal epithelioid angiosarcoma showing rhabdoid morphology on air‐dried smears

Diagnostic Cytopathology — Tue, 05 Apr 2011 23:00:00 +0100

(Source: Diagnostic Cytopathology)

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Primary cardiac angiosarcoma: in a patient with a dacron aortic prosthesis.

Texas Heart Institute Journal — Fri, 01 Apr 2011 23:00:04 +0100

Authors: Almeida NJ, Hoang P, Biddle P, Arouni A, Esterbrooks D This is a report of a primary cardiac angiosarcoma in a woman who, several years earlier, had undergone repair of an aortic dissection with a Dacron graft prosthesis. Dacron prostheses have rarely been associated with neoplasia, and this, to our knowledge, is the first reported case of primary cardiac angiosarcoma in association with Dacron. Our patient presented with extensive metastases. If tumors are localized, they can be treated successfully with a combination of surgical resection, chemotherapy, and radiotherapy. Cardiac transplantation can also be beneficial, but the overall prognosis remains poor. PMID: 21423471 [PubMed - in process] (Source: Texas Heart Institute Journal)

5-year survival after multiple repeat metastasectomy for pulmonary artery angiosarcoma.

The Annals of Thoracic Surgery — Thu, 31 Mar 2011 20:07:19 +0100

We report a case of a 39-year-old woman without evidence of disease 5 years after initial diagnosis and after multiple metastasectomies and pulmonary artery tumor endarterectomy. PMID: 21440106 [PubMed - in process] (Source: The Annals of Thoracic Surgery)

The Role of Radiation Therapy in the Management of Skin Cancers

Dermatologic Clinics — Tue, 29 Mar 2011 15:51:24 +0100

The use of radiation therapy in the management of skin cancer is variable and often anecdotal. Applied as both primary and adjuvant therapy in patients with both nonmelanoma skin cancer and rarer tumors of the skin, a consensus regarding optimal dosing regimens has not yet been reached. Herein, the authors outline the basic concepts of radiation therapy for tumors of the skin and review its use for high-risk nonmelanoma skin cancer, as well as less common malignancies, including angiosarcoma, Merkel cell carcinoma, and sebaceous carcinoma. (Source: Dermatologic Clinics)

5-Year Survival After Multiple Repeat Metastasectomy for Pulmonary Artery Angiosarcoma [CASE REPORTS]

The Annals of Thoracic Surgery — Mon, 28 Mar 2011 23:00:00 +0100

Cutaneous angiosarcoma of the leg showing radiation sensitivity

Australasian Journal of Dermatology — Mon, 28 Mar 2011 23:00:00 +0100

We report a case of cutaneous angiosarcoma occurring on the leg of a 97‐year‐old Japanese woman. Considering the patient's age and general condition, she was treated with electron beam irradiation, which led to the almost complete disappearance of the tumour. Because cutaneous angiosarcoma is an aggressive tumour with a high propensity for local recurrence and distant metastases, therapy preferably involves a multimodal approach. However, monotherapy with radiation may be effective in some cases of cutaneous angiosarcoma. (Source: Australasian Journal of Dermatology)

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Intrapericardial Angiosarcoma Invading the Anterior Wall of the Main Pulmonary Artery

Journal of Cardiac Surgery — Sun, 27 Mar 2011 23:00:00 +0100

(J Card Surg 2011;**:**‐**) (Source: Journal of Cardiac Surgery)

Invited commentary

Journal of Plastic, Reconstructive and Aesthetic Surgery — Sun, 27 Mar 2011 23:00:00 +0100

Lindford and colleagues have detailed their experience of radiation-induced angiosarcoma of the breast over a 10-year period, demonstrating good local control rates with surgical margins of greater than 3 cm. This is a rare but well recognised complication of breast conserving therapy and the authors should be commended for bringing it to the attention of this journal’s readership. Its incidence is likely to increase due to a shift towards more conservative breast cancer surgery and physicians must be vigilant of any vascular changes within previously irradiated tissue. Few case series exist and thus the natural history and management of this condition are yet to be fully understood and defined. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Disseminated Angiosarcoma of the Dialysis Fistula in 2 Patients Without Kidney Transplants

American Journal of Kidney Diseases — Thu, 24 Mar 2011 00:00:00 +0100

We report 2 cases of disseminated angiosarcoma of the dialysis fistula in hemodialysis patients without concurrent kidney transplants or immunosuppression. Both patients presented with symptoms of pain and bleeding at the site of the thrombosed fistula. Clinicians should be aware that angiosarcoma of the dialysis fistula can occur in patients without kidney transplants. (Source: American Journal of Kidney Diseases)

Continuing Medical Education: AFIP Archives: From the Archives of the AFIP: Pediatric Liver Masses: Radiologic-Pathologic Correlation Part 2. Malignant Tumors [Pediatric Imaging]

Radiographics recent issues — Thu, 17 Mar 2011 00:00:00 +0100

Malignant primary hepatic tumors in children include lesions unique to the pediatric age group and others that are more common in adults. Important considerations when evaluating a child with a liver tumor are the age of the patient, laboratory findings, and specific imaging features. The most common primary malignant hepatic tumor in the pediatric population, hepatoblastoma occurs almost exclusively in patients younger than 5 years with no history of liver disease. Hepatoblastoma is associated with elevated serum α-fetoprotein (AFP) level and appears predominantly solid. Hepatocellular carcinoma (HCC) is the most common malignant liver tumor in older children, often with a history of liver disease. HCC is associated with elevated serum AFP level and also appears as a solid mass. Fib...

From the Archives of the AFIP: Pediatric Liver Masses: Radiologic-Pathologic Correlation Part 2. Malignant Tumors [AFIP Archives]

Radiographics recent issues — Thu, 17 Mar 2011 00:00:00 +0100

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Contrasting Prognostic Implications of Platelet-Derived Growth Factor Receptor-β and Vascular Endothelial Growth Factor Receptor-2 in Patients with Angiosarcoma

Annals of Surgical Oncology — Wed, 16 Mar 2011 12:05:24 +0100

Conclusion Increased expression of PDGFR-β may be a statistically significant prognostic factor for poor OS, while increased expression of VEGFR-2 may be a favorable prognostic factor for patients with angiosarcoma. Content Type Journal ArticlePages 1-10DOI 10.1245/s10434-011-1640-4Authors Kan Yonemori, Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, JapanKoji Tsuta, Department of Clinical Laboratory, National Cancer Center Hospital, Tokyo, JapanMasashi Ando, Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, JapanAkihiro Hirakawa, Department of Management Science, Graduate School of Engineering, Tokyo University of Science, Tokyo, JapanYutaka Hatanaka, Department of Surgical Pathology, Hokkaido Univ...

Surgical management of radiation-associated cutaneous breast angiosarcoma

Journal of Plastic, Reconstructive and Aesthetic Surgery — Tue, 08 Mar 2011 00:00:00 +0100

Summary: The purpose of this study was to investigate the surgical management of radiation-associated cutaneous breast angiosarcoma with an emphasis on surgical margins and choice of reconstruction. Nine cases of angiosarcoma were identified in patients earlier treated with radiotherapy for breast cancer. Breast angiosarcoma was diagnosed a median of 5.25 years following radiotherapy. Median age at diagnosis was 60 years. Surgical treatment consisted of radical mastectomy (four cases), simple mastectomy (two cases) and wide local excision (three cases). Defect reconstruction involved three latissimus dorsi flap reconstructions and four skin grafts. Clear histological margins were achieved in all cases. Median follow-up was 81 months. Six patients were alive and disease-free at the end of t...

Paediatric intestinal cancer and polyposis due to bi-allelic PMS2 mutations: Case series, review and follow-up guidelines

European Journal of Cancer — Mon, 07 Mar 2011 00:00:00 +0100

Conclusions: Our findings show the association between bi-allelic germline PMS2 mutations and severe childhood-onset gastrointestinal manifestations, and support the notion that patients with early-onset gastrointestinal adenomas and cancer should be investigated for CMMR-D syndrome. We recommend yearly follow-up with colonoscopy from age 6 and simultaneous video-capsule small bowel enteroscopy from age 8. (Source: European Journal of Cancer)

Aspirin/clopidogrel: Haemorrhagic shock in a patient with hepatic angiosarcoma: case report

Reactions — Sun, 27 Feb 2011 18:11:29 +0100

(Source: Reactions)

Histology-Driven Chemotherapy in Soft Tissue Sarcomas

Current Treatment Options in Oncology — Sun, 27 Feb 2011 06:43:45 +0100

Opinion statement Doxorubicin and ifosfamide are the two chemotherapy drugs that have consistently demonstrated activity in “soft tissue sarcoma” (STS). However, STS is not a homogeneous entity but an umbrella term for a diverse group of more than 40 differing subtypes; each with distinct underlying biology, natural history and response to treatments. The accuracy of the histological and in some cases molecular diagnosis is therefore critical to the optimal treatment of these patients. Leiomyosarcomas have been shown to have limited responsiveness to ifosfamide, but both the combination of gemcitabine and docetaxel, and single agent trabectedin have shown considerable activity in this tumour group. Differences in responses to chemotherapy are seen for leiomyosarcomas o...

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Vinyl chloride industry in the courtroom and corporate influences on the scientific literature

American Journal of Industrial Medicine — Wed, 23 Feb 2011 00:00:00 +0100

AbstractPressure from the vinyl chloride (VC) industry on researchers involved in industry‐sponsored studies and on regulatory agencies has been documented since 1970s. This commentary describes the influence of a lawsuit pursued by workers of an Italian VC plant on the recent scientific debate on VC exposure and risk of hepatocellular carcinoma (HCC). Original studies carried out by consultants of the public prosecutors and by independent researchers supported the above association. VC‐industry consultants published two reviews during the lawsuit, claiming that liver angiosarcoma was the only VC‐related cancer. The judges concluded that the evidence of the association between HCC and VC was still not convincing. After the trial, the risk of HCC was confirmed by a re‐assessment of ...

Angiosarcoma in a patient with immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome

American Journal of Medical Genetics Part A — Fri, 18 Feb 2011 00:00:00 +0100

We present a patient with all clinical and laboratory findings of the ICF syndrome who died of a metastatic angiosarcoma of the liver. This is the first report of a non‐hematological malignancy in the ICF syndrome. The young age at which our patient developed an angiosarcoma suggests an effect of the defective DNA methylation observed in the ICF syndrome. Therefore, with improvement of recognition and treatment of the ICF syndrome, malignancy could become more common in this condition. © 2011 Wiley‐Liss, Inc. (Source: American Journal of Medical Genetics Part A)

Clinical and pharmacologic evaluation of two dose levels of intetumumab (CNTO 95) in patients with melanoma or angiosarcoma

Investigational New Drugs — Thu, 17 Feb 2011 17:00:54 +0100

Conclusions In patients with metastatic malignant melanoma and angiosarcoma in this study, intetumumab demonstrated manageable toxicity, was well tolerated, and presented approximately dose-proportional pharmacokinetics for the 10 mg/kg and 20 mg/kg doses. Content Type Journal ArticlePages 1-8DOI 10.1007/s10637-011-9639-zAuthors Steven J. O’Day, The Angeles Clinic and Research Institute, 2001 Santa Monica Boulevard, Suite 560W, Santa Monica, CA 90404, USAAnna C. Pavlick, New York University Medical Center, New York, NY USAMark R. Albertini, University of Wisconsin, Madison, WI USAOmid Hamid, The Angeles Clinic and Research Institute, 2001 Santa Monica Boulevard, Suite 560W, Santa Monica, CA 90404, USAHeidi Schalch, University of Wisconsin, Madison, WI USAZhihui Lang, Ce...

Tumour suppressor gene TP53 mutations in atypical vascular lesions of breast skin following radiotherapy

Histopathology — Wed, 16 Feb 2011 00:00:00 +0100

Conclusions: The presence of TP53 alterations suggests that its mutational inactivation may be implicated in the pathogenesis of radiation‐associated vascular proliferations. The common mutational pathway suggested by our data supports the hypothesis that AVL and AS are biologically related entities, most probably representing the extremes of a morphological continuum. (Source: Histopathology)

Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis.

Archives of Pathology and Laboratory Medicine — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Hart J, Mandavilli S Abstract Epithelioid angiosarcoma is a highly aggressive endothelial cell malignancy, most commonly arising in the deep soft tissues, but a variety of primary sites, including the adrenals, thyroid, skin, and bone, are encountered. On hematoxylin-eosin-stained sections, the pathologist encounters sheets of large, mildly to moderately pleomorphic epithelioid cells, with abundant eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. Obvious vasoformative foci may not be present, creating confusion with metastatic carcinomas, malignant mesothelioma, melanoma, anaplastic lymphoma, epithelioid peripheral nerve sheath malignancies, and epithelioid sarcoma. Moreover, malignancies with apparent vascular differentiation must be distinguished from less a...

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Selective intra-arterial Y-90 microsphere therapy in hemangioendothelioma.

The Turkish Journal of Gastroenterology — Tue, 01 Feb 2011 00:00:00 +0100

Authors: Laçın S, Küçük O, Oz I, Bılgıç S Epithelioid hemangioendothelioma is a malignant soft tissue tumor originating from the endothelial cell. Its clinical course varies from benign hemangioma to angiosarcoma. The therapy procedure remains unclear. Although resection of the tumor is the most frequently suggested treatment, due to its multinodular type, transplantation is frequently performed. Therapy regimens other than transplantation and resection are not effective and the median survival in hemangioendothelioma with unresectable lesions is approximately eight months. In this case, we report the therapeutic effect of selective intra-arterial radionuclide yttrium (Y)-90 microspheres and the value of F-18 fluorodeoxyglucose positron emission tomography/computed tomography t...

Osteosarcoma Arising in a Long-Standing Uterine Leiomyoma: A Case Report and Literature Review

International Journal of Surgical Pathology — Mon, 31 Jan 2011 00:00:00 +0100

The authors present the first case of a pure osteosarcoma arising in a long-standing uterine leiomyoma along with a literature review of all heterologous sarcomas arising in uterine leiomyoma. Most cases present with abnormal vaginal bleeding and symptoms related to a rapidly enlarged pelvic mass in postmenopausal women with a long-standing history of uterine leiomyoma. The histological finding of the case in this study revealed a relatively well-circumscribed tumor with a peripheral ring of leiomyoma and a central osteosarcoma. The case in this study further supported a possible pathogenesis involving the p53 gene. The prognosis may be better with low-stage tumor; however, cases with advanced stages, larger tumor size at presentation, and histological type of epithelioid angiosarcoma had ...

Massive Nodular Pseudoangiomatous Stromal Hyperplasia (PASH) of the Breast Arising Simultaneously in the Axilla and Vulva

International Journal of Surgical Pathology — Mon, 31 Jan 2011 00:00:00 +0100

The authors describe a 52-year-old woman with a history of bilateral mastectomies for macromastia caused by massive nodular pseudoangiomatous stromal hyperplasia (PASH), who presented with 2 large growths in her left axilla and groin. These masses had been increasing in size for nearly a year. When excised, the axillary mass had dimensions of 14.0 x 14.0 x 5.5 cm3 and weighed 664 g. The groin mass was slightly smaller at 14.5 x 11.0 x 5.0 cm3 and 518 g. Microscopic examination of both masses revealed breast tissue expanded by a hyalinized stroma with prominent slit-like pseudovascular spaces, consistent with PASH. Small incidental foci of PASH are common findings in breast excisions; however, large nodular foci are rare. Furthermore, nodular foci in accessory breast tissue are exceedingly ...

Diagnostic implications of oral intravascular papillary endothelial hyperplasia

Odontology — Thu, 27 Jan 2011 01:14:32 +0100

This study examined the clinical, histological, and immunohistochemical features as well as the differential diagnoses of oral intravascular papillary endothelial hyperplasia (IPEH) to aid clinicians and pathologists in its diagnosis. Clinical features of five oral IPEH cases were obtained from medical records, and all histopathological diagnoses were reviewed. Immunohistochemical reactions, including anti-CD-34, laminin, vimentin, estrogen receptor alpha, and Ki-67, were assessed. Microscopically, a reactive proliferation of vascular cells composed of small papillary structures with hypocellular and hyalinized cores arising in an organized thrombus was seen. CD-34, vimentin, and laminin staining were strongly positive, while estrogen receptor alpha was negative in all cases. A low p...

Breast angiosarcoma that is not related to radiation exposure: A comprehensive review of the literature

Surgery Today — Tue, 25 Jan 2011 06:48:40 +0100

Abstract Breast angiosarcomas that are not related to previous radiotherapy are very rare. Surgical resection is the primary treatment for these tumors, but there is no general agreement on the extent of surgery. The role of multimodality adjuvant treatment also remains controversial. The aim of this study was to summarize the available data from the largest published series of patients in terms of management and outcome. We also sought to identify prognostic factors influencing patient survival. We have included studies presenting detailed data on multimodality therapy and survival of patients with breast angiosarcoma. Ten studies presenting data on 280 patients were included in the review. Seventyfive percent of patients underwent a total mastectomy and 25% had breast-co...

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Endoscopic resection of intrathoracic tumors: experience with and long-term results for 26 patients.

Journal of Neurosurgery.Spine — Fri, 21 Jan 2011 00:00:00 +0100

Conclusions Endoscopic transthoracic approaches can reduce approach-related soft-tissue morbidity and facilitate recovery by preserving the normal tissues of the chest wall, by avoiding rib retraction and muscle transection, and by reducing postoperative pain. This less invasive approach thus shortens hospital stay and recovery time. PMID: 21250809 [PubMed - as supplied by publisher] (Source: Journal of Neurosurgery.Spine)

Feasibility of metronomic oral cyclophosphamide plus prednisolone in elderly patients with inoperable or metastatic soft tissue sarcoma

European Journal of Cancer — Thu, 20 Jan 2011 00:00:00 +0100

Conclusion: Metronomic CPM showed good safety results for this frail population, with promising activity in patients with radiation-induced sarcoma. Toxicity profile was favourable, allowing prolonged home staying and rare treatment discontinuations. A larger prospective study is warranted to confirm these encouraging results in elderly with STS. (Source: European Journal of Cancer)

A Monoclonal Antibody To Secreted Frizzle Related Protein-2 Inhibits Angiosarcoma Growth In Vivo

Journal of Surgical Research — Wed, 19 Jan 2011 20:25:29 +0100

(Source: Journal of Surgical Research)

Bilateral superior epigastric pedicle perforator flaps for total chest wall coverage

Journal of Plastic, Reconstructive and Aesthetic Surgery — Tue, 18 Jan 2011 00:00:00 +0100

We present a case of a patient with recurrent angiosarcoma, who required total anterior chest wall reconstruction. This was achieved using bilateral pedicled SEA perforator flaps for complete coverage. To our knowledge, this is the first documented case of bilateral pedicled perforator flap reconstruction for complete chest wall reconstruction. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

A Case of Epithelioid Angiosarcoma of the Scalp Treated With Paclitaxel and Radiotherapy [Correspondence]

Archives of Dermatology — Mon, 17 Jan 2011 00:00:00 +0100

(Source: Archives of Dermatology)

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Posteromedial diaphragmatic hernia following pediatric liver transplantation

Pediatric Transplantation — Sun, 16 Jan 2011 00:00:00 +0100

Moon S‐B, Jung S‐M, Kwon C‐H, Kim S‐J, Joh J‐W, Seo J‐M, Lee S‐K. Posteromedial diaphragmatic hernia following pediatric liver transplantation. Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S.Abstract: Diaphragmatic hernia is a rare complication following pediatric LT. Here, four children who developed right‐sided posteromedial diaphragmatic hernias after LT are reported. The primary disease was biliary atresia in two patients, hemangioendothelioma in one, and angiosarcoma in one patient. All of the patients underwent living‐donor LT using a left lateral graft. The patients presented with abdominal and/or pulmonary signs and symptoms. The diaphragmatic hernias were diagnosed at 28 days to seven months post‐transplant by standard radiographs or che...

Intimal angiosarcoma causing abdominal aortic rupture

Journal of Vascular Surgery — Mon, 10 Jan 2011 00:00:00 +0100

We report a patient who presented with a contained ruptured infrarenal aorta with clinical and radiologic findings suggestive of infectious aortitis. Surgical resection, regional debridement, and reconstruction were completed using a cadaveric arterial homograft. However, pathologic evaluation revealed a high-grade intimal sarcoma. (Source: Journal of Vascular Surgery)

Primary multicentric cutaneous epithelioid angiosarcoma

Indian Journal of Dermatology, Venereology and Leprology — Thu, 06 Jan 2011 00:00:00 +0100

We report a case of an 81-year-old lady who presented with two ulcerated plaques over the right temporal and parietal scalp of 1 year duration. The right submaxillary and submandibular lymph nodes were enlarged and tender. Computed tomography (CT) scan of the head showed soft tissue swelling over parietal and temporal areas and there was no intracranial extension. Ultrasonogram of the abdomen showed hyperechoic areas in liver suggestive of secondaries. Histopathology of the skin lesion showed the dermis and subcutis composed of clusters of atypical epithelioid cells with vesicular nuclei, prominent nucleoli and eosinophilic cytoplasm with increased mitotic figures. Immunohistochemical staining revealed CD-31, 33, 34 and vimentin positivity, while cytokeratin was negative confirming the dia...

Angiosarcoma of the scalp with complete response to a biweekly gemcitabine and docetaxel (GEMDOC) chemotherapy regimen.

Ear, Nose and Throat Journal — Sat, 01 Jan 2011 00:00:00 +0100

We describe a case involving a 75-year-old woman who presented to the emergency department at the Detroit Medical Center with multiple painful scalp lesions. She had had similar lesions intermittently for several years that apparently had responded to treatment with antifungal creams, but those occurring in the 6 months before her presentation had not responded to that therapy. The final diagnosis was a metastatic angiosarcoma. The patient achieved complete remission following treatment with a combination chemotherapy regimen consisting of gemcitabine (1,500 mg/m(2)) and docetaxel (50 mg/m(2)) administered biweekly. The patient was free of disease at the 15-month follow-up. This regimen is well tolerated and should be considered, especially in elderly patients and patients with comorbid co...

Hepatic angiosarcoma of childhood: a case report and review of literature

Journal of Pediatric Surgery — Sat, 01 Jan 2011 00:00:00 +0100

Abstract: Angiosarcomas are rare tumors that predominantly affect adults. Hepatic angiosarcoma in a child is an extremely rare event and is associated with a poor prognosis. Herein, we report our experience in a case of hepatic angiosarcoma in a child who presented with a huge unresectable mass that underwent liver transplantation. (Source: Journal of Pediatric Surgery)

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Endovascular papillary angioendothelioma (Dabska tumor): underrecognized malignant tumor in childhood

Journal of Pediatric Surgery — Sat, 01 Jan 2011 00:00:00 +0100

Abstract: Endovascular papillary angioendothelioma, or Dabska tumor, was first presented in 1969 by Maria Dabska where she presented cases occurring in 6 children. The tumor was described as being a low-grade angiosarcoma characterized by papillary endovascular proliferations of atypical endothelial cells and anastomosing vascular channels within the dermis. Since its original description, only 30 case reports have been written describing the varying presentation, clinical course, and histopathology of this tumor. This case report documents the presentation and management of endovascular papillary angioendothelioma in a young male and reviews the current literature. Because more cases of EPAs are reported, perhaps a more standard approach to accurate diagnosis and treatment with surgical i...

Distinct histological features characterize primary angiosarcoma of bone

Histopathology — Sat, 01 Jan 2011 00:00:00 +0100

Conclusions: Because keratin positivity is seen in the majority of cases, pathologists should avoid misinterpretation as metastatic carcinoma. A macronucleolus, three or more mitoses per 10 HPF and fewer than five eosinophilic granulocytes per 10 HPF can be used to further define angiosarcoma of bone. (Source: Histopathology)

An unusual and potentially misleading phenotypic change in a primary gastrointestinal stromal tumour (GIST) under imatinib mesylate therapy

Virchows Archiv — Wed, 29 Dec 2010 17:09:35 +0100

We present a unique case of a 62-year-old female who was diagnosed with a huge gastric gastrointestinal stromal tumour (GIST). Core needle biopsy revealed a cellular spindle cell GIST with diffuse expression of CD117 and CD34. Four mitotic figures were counted in ten available HPFs, indicating a high-risk tumour. Computed tomography scan, performed after 8 months of neoadjuvant imatinib mesylate treatment (Glivec, 400 mg/day), revealed a partial response with reduction of tumour size from 20 × 15 × 15 cm to 13.3 × 8 × 7.6 cm. The patient underwent complete tumour resection. The tumour revealed extensive cystic changes and hyalinisation in 90% of the tumour mass. Multiple viable tumour clones, measuring up to 1 cm, showed highly anaplastic, ...

Cutaneous angiosarcoma. Analysis of 434 cases from the Surveillance, Epidemiology, and End Results Program, 1973-2007

Annals of Diagnostic Pathology — Wed, 29 Dec 2010 00:00:00 +0100

Abstract: Cutaneous angiosarcoma is an aggressive malignant mesenchymal vasoformative neoplasm that accounts for 1% of all soft tissue sarcomas. Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we analyzed the demographics and survival of cutaneous angiosarcoma. The Surveillance, Epidemiology, and End Results program recorded 434 cases of cutaneous angiosarcoma from 1973 to 2007. The incidence was nearly the same in men (222 cases) and women (212 cases). Most patients were white (88%) with a mean age of 73 years. African Americans made up only 4% of the cases. Two hundred seventy (62%) cases were tumors of the head and neck, whereas 106 (24%) cases arose in the skin of the trunk. Grade was recorded in 194 cases (45%): 28 were grade I, 44 ...

Heterologous and Rare Homologous Sarcomas of the Uterine Corpus: A Clinicopathologic Review

Advances in Anatomic Pathology — Tue, 21 Dec 2010 05:04:40 +0100

Pure sarcomas of the uterine corpus are uncommon, constituting less than 3% of all malignancies at this site, and most of them are leiomyosarcomas and endometrial stromal sarcomas. Rare histotypes of homologous sarcomas and heterologous sarcomas are occasionally encountered, and the absence of significant accumulated experience with these histotypes at this location may potentially raise diagnostic and patient management difficulties. In this article, the clinicopathologic attributes of all earlier reported sarcomas of the uterine corpus other than leiomyosarcomas and endometrial stromal sarcomas are summarized. Included are embryonal rhabdomyosarcoma, pleomorphic rhabdomyosarcoma, angiosarcoma, alveolar soft part sarcoma, malignant perivascular epithelioid cell tumors (PEComas), osteosarc...

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Sarcomas of the skin in the elderly

Clinics in Dermatology — Mon, 13 Dec 2010 23:58:49 +0100

Abstract: Malignant mesenchymal neoplasms of skin and soft tissues are characterized by an extreme clinicopathologic heterogeneity. Although all sarcomas of deep soft tissues may also arise in superficial locations, there are important clinicopathologic differences. Lipogenic sarcomas represent the most frequent type of sarcomas in deep soft tissues, but purely dermal liposarcomas are exceedingly rare. Vascular and fibroblastic or myofibroblastic sarcomas, however, are much more frequent in dermal location. In contrast with most deep-seated sarcomas, morphologic grading of dermal sarcomas has only a limited importance because most types of dermal sarcoma have a rather favorable clinical prognosis. Important exceptions to this rule are epithelioid sarcoma and cutaneous angiosarcoma, which a...

Experience of angiosarcoma in the North of England Bone and Soft Tissue Tumour Service

Journal of Plastic, Reconstructive and Aesthetic Surgery — Fri, 10 Dec 2010 00:00:00 +0100

Conclusions: Angiosarcomas are aggressive, difficult to treat tumours, which can occur secondary to a multitude of causes. Clinical suspicion, biopsy and early diagnosis are essential to allow optimum treatment, which currently consists of radical surgery, together with adjuvant radiotherapy and chemotherapy. (Source: Journal of Plastic, Reconstructive and Aesthetic Surgery)

Successful treatment of an angiosarcoma of the head – options for systemic therapy

JDDG — Thu, 02 Dec 2010 00:00:00 +0100

(Source: JDDG)

An unusual cause of pericarditic chest pain.

British Journal of Hospital Medicine — Wed, 01 Dec 2010 00:00:00 +0100

Authors: Dubrey SW, Grocott-Mason R, Doyle J, Mittal T, Rice A Pericarditis is a relatively common cause of hospital admission in young to middleaged men. The aetiology is usually infective, inflammatory or autoimmune, although it is rarely caused by underlying primary cardiac malignancy. Primary tumours of the heart are rare, with a reported autopsy prevalence of 0.001-0.28% (Reynen, 1996). Approximately 75% are benign and 50% of these are myxomas. The most frequent malignant tumours (35-40%) are angiosarcomas (Menq et al, 2002), which also predominantly affect middle-aged men. PMID: 21135771 [PubMed - in process] (Source: British Journal of Hospital Medicine)