MedWorm: Angiosarcoma

Spontaneous Metastatic Angiosarcoma of the Tongue in a Wistar rat: Morphological and Immunohistochemical Characterization.

Toxicologic Pathology — Tue, 09 Mar 2010 00:00:00 +0100

Authors: Pace V, Wieczorek G, Pace M, Weber K, Perentes E A primary angiosarcoma was found in the tongue of a six-week-old female Wistar rat, sacrificed for humane reasons during the course of a four-week toxicology study. At necropsy, a nodule protruding from the dorsal part of the tongue was found. The nodule displayed microscopically, irregularly shaped vascular spaces separated by collagenous stroma. The spindle-shaped endothelial cells showed pleomorphism, hyperchromatism, and low mitotic activity; large nuclei with one or more nucleoli were present. Multiple metastases were found in the lungs, and the morphology of the cells resembled that of the primary tumor. Immunohistochemically, the primary tumor and the lung metastases were positive for von Willebrand factor and vimentin. T...

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Cutaneous angiosarcoma: own experience over 13 years. Clinical features, disease course and immunohistochemical profile

Journal of the European Academy of Dermatology and Venereology — Thu, 04 Mar 2010 00:00:00 +0100

Background Cutaneous angiosarcoma (AS) is a rare malignant tumour of endothelial origin with very poor prognosis, frequent recurrences and high metastatic potential. Clinical suspicion is often raised too late, but histological findings and immunohistochemical assays have proved to be very helpful in the diagnostic process.Patients and methods Over the last 13 years, nine patients with AS were found in our archives. Clinical features, evolution, treatment and outcome were analysed and all biopsy specimens were reviewed by a trained dermatopathologist, with subsequent immunohistochemical assessment.Results and conclusions Cutaneous AS was clinically diagnosed in 4 of 9 patients, while systemic lupus erythematosus was the most common misdiagnosis. Radiotherapy was the most prescribed treatme...

Pediatric angiosarcoma of soft tissue: a rare clinicopathologic entity.

Archives of Pathology and Laboratory Medicine — Mon, 01 Mar 2010 00:00:00 +0100

Authors: Ayadi L, Khabir A Abstract Angiosarcomas are rare tumors that predominantly affect adults and elderly patients. Although angiosarcomas are well described in a variety of clinical settings, they have been poorly studied in children and little is known about their biology, natural history, or optimal treatment. Childhood angiosarcomas are exceedingly rare. The head and neck region and mediastinum seem to be the preferred locations. Most tumors are high-grade tumors. Vasoformative architecture is not always obvious on light microscopy requiring the benefit of immunohistochemical study. The differential diagnosis includes Kaposi sarcoma, epithelioid hemangioendothelioma, hemangiopericytoma, and spindle cell hemangioendothelioma whose prognosis is different. Complete resection is r...

Angiosarcoma developing in a non-functioning arteriovenous fistula post-renal transplant

Journal of Surgical Oncology — Fri, 26 Feb 2010 00:00:00 +0100

We report the case of a 48-year-old male who developed an angiosarcoma in a ligated native AV fistula. The lesion arose on the background of immunosuppression following a successful ABO-incompatible renal transplant for chronic renal failure.Angiosarcomas are extremely rare tumours but should be considered as a differential diagnosis for an evolving mass near the site of an AV fistula. Diagnosis relies on an index of suspicion and obtaining a definitive histological diagnosis. Both clinicians and patients should be aware that an evolving mass within or around an AV fistula should prompt urgent biopsy. J. Surg. Oncol. © 2010 Wiley-Liss, Inc. (Source: Journal of Surgical Oncology)

Fine-needle aspiration of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver: A diagnostic dilemma

Diagnostic Cytopathology — Wed, 24 Feb 2010 00:00:00 +0100

We present a case of metastatic radiation-induced cutaneous epithelioid angiosarcoma of the breast to the liver and a review of the literature. Diagn. Cytopathol. 2010. © 2010 Wiley-Liss, Inc. (Source: Diagnostic Cytopathology)

Protracted disseminated skeletal metastases from angiosarcoma of the spleen

Clinical and Experimental Metastasis — Sat, 20 Feb 2010 06:53:08 +0100

Abstract Angiosarcomas are high-grade vascular tumors associated with poor prognosis due to their aggressive nature. Occasional skeletal manifestations present commonly as osteolytic destruction. The 55-years-old patient presented in this case report had a disease-free 4 years interval between splenectomy after primary angiosarcoma of the spleen and an unusual skeletal metastatic pattern mimicking benign angiomatosis. Despite lacking radiographic evidence for a highly aggressive osseous process, the histopathological resemblance of the bone biopsy with the primary tumor manifestation and the fulminant course of disease after onset of disseminated osseous spread confirmed the malignant character of the vascular tumor. The case demonstrates the highly variable radiograph...

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Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma

Journal of Cutaneous Pathology — Thu, 18 Feb 2010 00:00:00 +0100

Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation. Tatsas AD, Keedy VL, Florell SR, Simpson JF, Coffin CM, Kelley MC, Cates JMM. Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma. (Source: Journal of Cutaneous Pathology)

Expression of Vascular Notch Ligand Delta-Like 4 and Inflammatory Markers in Breast Cancer.

The American Journal of Pathology — Thu, 18 Feb 2010 00:00:00 +0100

We examined 296 breast adenocarcinomas and 38 ductal carcinoma in situ tissues that were represented in tissue microarrays. Additional whole sections representing 10 breast adenocarcinomas, 10 normal breast tissues, and 16 angiosarcomas were included. Immunohistochemistry was then performed by using validated antibodies against Dll4, CD68, CD14, DC-SIGN, CD123, neutrophil elastase, CD31, and carbonic anhydrase 9. Dll4 was selectively expressed by intratumoral endothelial cells in 73% to 100% of breast adenocarcinomas, 18% of in situ ductal carcinomas, and all lactating breast cases, but not normal nonlactating breast. High intensity of endothelial Dll4 expression was a statistically significant adverse prognostic factor in univariate (P = 0.002 and P = 0.01) and multivariate analyses (P = ...

[Diseases of the hepatobiliary system as a cause of acute abdomen.]

Der Radiologe — Wed, 17 Feb 2010 00:00:00 +0100

Authors: Schima W, Kölblinger C, Eisenhuber-Stadler E, Kulinna-Cosentini C, Ba-Ssalamah A Diseases of the liver and biliary system are common causes of acute abdominal pain and gallstone disease predisposes to cholecystitis and cholangiolithiasis. Sonography is the method of choice for the assessment of cholecystitis, whereas magnetic resonance cholangiopancreaticography (MRCP) is the standard technique to detect stones in the common bile duct. Multi-detector computed tomography (MDCT) is ideal for detection of associated complications, including abscess formation and gall stone ileus. Pyogenic, amebic and fungal liver abscesses are reliably diagnosed with MDCT which can also be used for interventional radiologic therapy of liver abscesses by percutaneous aspiration or drainage pr...

Angiosarcoma after breast-conserving therapy

Cancer — Tue, 16 Feb 2010 00:00:00 +0100

With breast-conserving therapy (BCT) as the standard of care for patients with noninvasive and early stage invasive breast cancer, a small incidence of post-BCT angiosarcoma has emerged. The majority of therapeutic interventions have been unsuccessful. To the authors' knowledge, there is no consensus in the medical literature to date regarding the treatment of this malignancy. The current study was conducted to report the long-term outcomes of a novel approach using hyperfractionated and accelerated radiotherapy (HART) for angiosarcoma developing after BCT.The authors retrospectively reviewed the outcomes of 14 patients treated with HART with or without surgery at the University of Florida between November 1997 and March 2006 for angiosarcoma that developed after BCT.At the time of last fo...

Preclinical Investigation of PEGylated Tumor Necrosis Factor {alpha} in Dogs with Spontaneous Tumors: Phase I Evaluation.

Clinical Cancer Research — Tue, 16 Feb 2010 00:00:00 +0100

CONCLUSIONS: Using a clinically relevant, spontaneous large animal model of neoplasia, we have shown that biologically effective doses of PEG-TNF can be administered safely, and that PEG-TNF administration is associated with encouraging biological activity. These results justify the clinical evaluation of PEG-TNF in human cancer. Clin Cancer Res; 16(5); OF1-11. PMID: 20160058 [PubMed - as supplied by publisher] (Source: Clinical Cancer Research)

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[Radiation-induced breast angiosarcoma following breast-conserving therapy. Report of two cases.]

Gynecologie, Obstetrique & Fertilite — Thu, 11 Feb 2010 00:00:00 +0100

We report two cases of radiation-induced breast angiosarcoma in two patients having benefited from breast conserving surgery with radiation. We shall put emphasis on the etiopathogeny of these tumours and their clinical and therapeutic aspects. PMID: 20153679 [PubMed - as supplied by publisher] (Source: Gynecologie, Obstetrique & Fertilite)

Aortic Angiosarcoma: A Rare Cause for Leaking Thoracic Aneurysm

CardioVascular and Interventional Radiology — Wed, 10 Feb 2010 06:52:56 +0100

We report the case of a 56-year-old man whose initial presentation and investigations lead to emergency endovascular stenting of a descending thoracic aneurysm with a contained leak. Initial response was favourable, yet the patient presented again with worsening symptoms. The circum-aortic haematoma expanded by 50% on subsequent imaging, but no endoleak was identified. When altered bone marrow signal was identified on magnetic resonance imaging, the possibility of malignancy was considered. A metastatic skin lesion was then biopsied, which demonstrated morphological and immunohistochemical features consistent with metastases from a pleomorphic sarcoma of the aorta. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00270-009-9776-3Authors S. L. Hales, St. Mary’s Hospi...

[Cutaneous metastasis revealing epithelioid angiosarcoma of the abdominal aorta.]

Annales de Dermatologie et de Cenereologie — Mon, 01 Feb 2010 00:00:00 +0100

We report a case revealed by skin metastasis. CASE REPORT: An 85-year-old man presented skin tumours associated with deterioration of his general condition and intense pain of the right lower limb. Physical examination showed three nodules of the lumbar area associated with an ipsilateral livedo extending to the right lower limb. The course of the disease involved distal ischaemia. Arterial ultrasound, aortography and CAT showed ectasia of the abdominal aorta with thrombosis and right subpopliteal occlusion. Histological examination of a nodule showed proliferation of malignant cells with expression of vimentin, CD 31, cytokeratins AE1/AE3 and cytokeratin 7. Stain for CD34 was negative. Histological investigation of the livedo showed a vascular embolus with epithelial-type cells positive f...

Med Sci Monit 2010; 16(2):CR61-66 "Results of hepatic resection for primary hepatic angiosarcoma in adults"

Medical Science Monitor — Fri, 29 Jan 2010 15:18:37 +0100

Conclusions: Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture. (Source: Medical Science Monitor)

Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience

Journal of Surgical Oncology — Fri, 29 Jan 2010 00:00:00 +0100

The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma.Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified. Clinicopathologic factors were reviewed. Characteristics of primary and secondary angiosarcoma were compared.Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified. The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma - 43 years versus 73 years (P < 0.0001). Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001). Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years. Median tumor size was 7.0 cm f...

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Intraabdominal Locations of Intravascular Papillary Endothelial Hyperplasia (Masson's Tumor): A Rare and Novel Etiology of GI Bleeding and Review of the Literature

Journal of Surgical Research — Mon, 25 Jan 2010 16:40:27 +0100

Conclusion: IPEH is a reactive process, with 3 subtypes all involving the proliferation of epithelial cells around a thrombus in the setting of venous stasis. In its pure form, the organized thrombus is solely localized within the vascular lumen. Mixed form IPEH is formed in preexisting vascular lesions (such as arteriovenous malformation, hemangioma, pyogenic granuloma, etc.). The rarest form is the extravascular variety which arises in hematomas often from recent trauma to the area. In its pure form, IPEH has a zero recurrence rate when an R0 resection is performed; all mixed and extravascular forms show the highest recurrence rates. The exact histogenesis of these epithelial cells remains a mystery and multiple theories have been offered. Although difficult to distinguish from malignant...

Primary Cardiac Angiosarcoma in a Young Woman

Karger Publishers — Fri, 22 Jan 2010 23:00:00 +0100

Case Rep Oncol 2010;3:2429 (DOI:10.1159/000273112) (Source: Karger Publishers)

Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses

Cytopathology — Fri, 22 Jan 2010 00:00:00 +0100

Conclusions: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common. Very few reliable data are available concerning specificity of CD31 on cytological material. (Source: Cytopathology)

Angiosarcoma-like metastatic carcinoma of the liver.

Pathology, Research and Practice — Fri, 22 Jan 2010 00:00:00 +0100

Authors: Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described. The first case was a 53-year-old female with cystic liver tumors which were found 22 months after surgery for ureteral cancer. The second case was an 81-year-old female with multiple tumors in the liver and the pancreas, and a post-mortem examination was carried out. She had undergone surgery for skin cancer three years before. Both cases had an angiosarcoma-like appearance macroscopically and microscopically. Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but ca...

Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall

Breast Cancer Research and Treatment — Tue, 19 Jan 2010 17:45:53 +0100

Abstract Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949–1988 developed angiosarcomas in edematous arms (Stewart–Treves syndrome) after median 11 years, and 17 females treated by segm...

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Primary pleural epithelioid angiosarcoma. A case report and review of the literature.

Pathology, Research and Practice — Mon, 18 Jan 2010 00:00:00 +0100

We report herein a further case of a 62-year-old man who presented with progressive dyspnea and bilateral massive hemothorax. The overall pathological and immunohistochemical features of the pleural specimens supported the diagnosis of epithelioid angiosarcoma. PMID: 20089367 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

Hepatic epithelioid hemangioendothelioma: review of three cases

Clinical Imaging — Fri, 01 Jan 2010 00:00:00 +0100

We report the imaging features in three cases of histologically proven hepatic EHE. The imaging features suggestive of EHE will be emphasized, especially for multinodular lesions suggesting liver metastases in patients with no known primary extrahepatic malignancy. (Source: Clinical Imaging)

Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen.

The British Journal of Radiology — Fri, 01 Jan 2010 00:00:00 +0100

We report on a 15-year-old boy who presented with right TMJ swelling and subsequently developed epigastric and right upper quadrant pain. The TMJ swelling proved to be odontogenic myxofibroma and the abdominal pain was a result of primary splenic angiosarcoma with hepatic metastasis. We report for the first time the synchronous presentation of PAS and odontogenic myxofibroma in a paediatric patient, and we describe the radiological features along with the histological diagnosis and clinical outcome. Uptake in (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography is also described for the first time for both these tumours. PMID: 20139242 [PubMed - in process] (Source: The British Journal of Radiology)

Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung

Medical Molecular Morphology — Wed, 23 Dec 2009 23:03:12 +0100

We report a case with focus on immunocytochemistry of imprint cytological specimens here. A 43-year-old Japanese man presented with cough. Brushing cytology of the tumor using a bronchoscope showed a malignant neoplasm. Subsequently, left lower lobectomy was undertaken. Imprint cytological material of the neoplastic cells noted some clusters of round, or oval, to polygonal epithelioid cells. Histological examination showed the proliferation of epithelioid neoplastic cells containing erythrocytes in the cytoplasm. The immunocytochemistry in imprint cytological specimens showed a focal positive reaction for von Willebrand factor, and the immunohistochemistry of the surgically resected lung tumor showed a focal positive reaction for Fli-1, von Willebrand factor, CD31, and CD34. Finally...

Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib

British Journal of Dermatology — Tue, 22 Dec 2009 00:00:00 +0100

(Source: British Journal of Dermatology)

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Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib.

The British Journal of Dermatology — Mon, 21 Dec 2009 00:00:00 +0100

Authors: Donghi D, Dummer R, Cozzio A PMID: 20030640 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Acantholytic squamous cell carcinoma in a cow

Comparative Clinical Pathology — Fri, 18 Dec 2009 07:07:09 +0100

Abstract A subcutaneous mass in the perineal area of a female Holstein cow underwent histo-pathological evaluation. Microscopically, this lesion revealed a prominent alveolar pattern that extended into the dermis with internal pseudolumina that contained detached tumour cells. Histo-chemically, tumour cells were mucin-negative. Immuno-histochemistry revealed intra-cytoplasmic reactivity for cytokeratin MNF116 and cytokeratin 10 with strong staining intensity for Glut1 located on the cell membrane, however, cells were negative for cytokeratin 7, 8 and 20, Vimentin and vWF, suggesting they originated from stratified epithelia and not from ductal or glandular epithelia as well as differentiating from sarcomas like angiosarcoma. Immuno-staining results further verified that th...

Atypical presentation of angiosarcoma of the scalp in the setting of Human Immunodeficiency Virus (HIV)

World Journal of Surgical Oncology — Fri, 18 Dec 2009 00:00:00 +0100

Conclusions: South Africa is at the epicenter of the HIV epidemic. Consequently, the management of patients in the field of oncology in our clinical practice is often burdened with malignancies manifesting with an atypical disease presentation and clinical course. (Source: World Journal of Surgical Oncology)

MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema.

The American Journal of Pathology — Fri, 11 Dec 2009 00:00:00 +0100

In conclusion, despite their identical morphology, secondary AS are genetically different from primary AS and are characterized by a high frequency of high level amplifications of MYC. This finding may have implications both for the diagnosis and treatment of these tumors. PMID: 20008140 [PubMed - as supplied by publisher] (Source: The American Journal of Pathology)

Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1α: a histologic and immunohistochemical study of 45 cases

Annals of Diagnostic Pathology — Fri, 11 Dec 2009 00:00:00 +0100

Abstract: Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis. Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its mechanism has not been fully established. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to hypoxia.. The stability of HIF can regulate key proteins in angiogenesis and the α-subunit has been found in epithelial tumors, only 1 case of human retroperitoneal angiosarcoma, and rare vascular proliferations and tumors in knockout mice. We wanted to observe the utility of HIF-1α as a marker or explanatory factor in AS. Cases coded...

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Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy

International Journal of Clinical Oncology — Fri, 04 Dec 2009 22:14:06 +0100

Abstract Angiosarcoma of the breast is an aggressive malignancy of endothelial origin with a tendency for localregional recurrence. The involvement of angiosarcomas in the bilateral breasts has rarely been documented. Of note, due to its rarity and typically unclear clinical findings upon examination, the diagnosis of a contralateral lesion can be difficult, particularly in women during pregnancy. Here we present a rare case of bilateral angiosarcoma of the breast during pregnancy. A 32-year-old woman was referred to our unit with complaints of progressive swelling of the left breast, with tenderness. Magnetic resonance imaging showed a small, circumscribed high-intensity area in the contralateral breast, with pattern similar to that of the lesion found in the left breast....

The Adrenal Mass: Correlation of Histopathology with Imaging

Annals of Surgical Oncology — Fri, 04 Dec 2009 07:21:08 +0100

Conclusion CT or MR characteristics predicted the presence of benign lesions with 100% specificity. Every adrenal malignancy had CT or MR results that were inconsistent with benign adenoma (100% sensitivity). To exclude malignancy, adrenal masses with non-benign imaging characteristics should be resected. Content Type Journal ArticleCategory Endocrine TumorsDOI 10.1245/s10434-009-0829-2Authors Linwah Yip, University of Pittsburgh School of Medicine Department of Surgery Pittsburgh PA USAMitchell E. Tublin, University of Pittsburgh School of Medicine Department of Radiology Pittsburgh PA USAJohn A. Falcone, University of Pittsburgh School of Medicine Department of Surgery Pittsburgh PA USACory R. Nordman, University of Pittsburgh School of Medicine Department of Radiol...

CD10 Is Expressed in Most Epithelioid Hemangioendotheliomas: A Potential Diagnostic Pitfall.

Archives of Pathology and Laboratory Medicine — Tue, 01 Dec 2009 00:00:00 +0100

Conclusions.-CD10 has a sensitivity of 78% (confidence interval, 63.6%-92.4%) and specificity of 70% (confidence interval, 54%-85.9%) for EHE. There is a growing list of tumors that show expression of CD10. Pathologists should be aware of this diagnostic pitfall. PMID: 19961253 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)

[Studies on claudins and prognostic factors in gastrointestinal diseases.]

Magyar Onkologia — Tue, 01 Dec 2009 00:00:00 +0100

Authors: Gyorffy H Gastrointestinal tumors are highly ranked regarding tumoral mortality worldwide. The development and progression of gastrointestinal (GI) diseases go hand in hand with the changes of tight junctions (TJ). Claudins (CLDN) are the main TJ proteins, showing different expression by the different tissues, with the expressed CLDN profile being representative. I. We explored the changes of CLDN expression in Barrett's esophagus and related adenocarcinoma. CLDN2 and -3 expression in Barrett's esophagus was higher than in normal foveolar epithelium. Adenocarcinoma showed higher CLDN2 and -3 expression compared with normal and Barrett's epithelia. The similar CLDN expression profile of Barrett's esophagus and adenocarcinoma supports their sequential development. II. Gastric in...

Primary epithelioid angiosarcoma of the breast masquerading as carcinoma

Current Oncology — Tue, 17 Nov 2009 16:12:53 +0100

ABSTRACT Here we report a case of primary epithelioid angiosarcoma (eas) of the breast occurring in a 30-year-old woman. Following fine-needle asspiration cytology (fnac) and tru-cut biopsy, the patient was initially diagnosed with mammary carcinoma and thereafter underwent modified radical mastectomy. Postoperative histopathologic examination and immunohistochemistry revealed a diagnosis of primary epithelioid angiosarcoma of the breast. The patient received postoperative radiotherapy to the chest wall and was started on adjuvant thalidomide. Preoperatively, eas can be mistaken for carcinoma because it is difficult to appreciate the typical morphology on fnac or tru-cut biopsy. Indeed, this is an area of potential diagnostic error because, nowadays, neoadjuvant therapy is often instituted...

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Postirradiation Sarcoma: Clinicopathologic Features and Role of Chemotherapy in the Treatment Strategy

Sarcoma — Tue, 17 Nov 2009 13:48:16 +0100

Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies. (Source: Sarcoma)

Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face

Human Pathology — Mon, 16 Nov 2009 00:00:00 +0100

Summary: Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons. To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle–related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma. Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 × 10−4). Similar differences were also found in cyclin A, cycl...

A case report of primary gingival angiosarcoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics — Sat, 14 Nov 2009 14:14:54 +0100

This study reports clinico-pathological features and CT image finding of a case of primary angiosarcoma in the upper gingival and a review of previously reported cases of primary gingival angiosarcomas including the present case. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

Soft tissue sarcomas with complex genomic profiles

Virchows Archiv — Thu, 12 Nov 2009 18:39:06 +0100

Abstract Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogen...

Transient response of cardiac angiosarcoma to paclitaxel

European Journal of Cancer Care — Wed, 11 Nov 2009 00:00:00 +0100

We present here the case of a patient with primary cardiac angiosarcoma that highlights the misdiagnosis at clinical presentation, current diagnostic modalities and a possible new treatment using paclitaxel for cardiac angiosarcoma. (Source: European Journal of Cancer Care)

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Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.

Archives of Pathology and Laboratory Medicine — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Lucas DR Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer. Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients. However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations. Predisposing conditions include environmental exposures to chemical or radioactive sources. Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy. The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years. Atypical vascular lesion refers to a small, usually lymphatic-type vascular proliferation in radiated skin. ...

Hemangiomas, Angiosarcomas, and Vascular Malformations Rep-resent the Signaling Abnormalities of Pathogenic Angiogenesis.

Current Molecular Medicine — Sun, 01 Nov 2009 00:00:00 +0100

Authors: Arbiser JL, Bonner MY, Berrios RL Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin. Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease. Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood. In our previous studies, we have found that tumor vasculature in human solid tumors expresses similarities in signaling to that of hemangiomas, making the knowledge of signaling in hemangiomas widely applicable. These similarities include expression of reactive oxygen, NFkB and akt in tumor vasculature. Furthermore, we have studied malignant v...

Thorium dioxide: Primary cerebral angiosarcoma in an elderly patient: case report

Reactions — Mon, 19 Oct 2009 13:04:56 +0100

(Source: Reactions)

Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma

Human Pathology — Fri, 16 Oct 2009 00:00:00 +0100

We report a patient with a mixed testicular germ cell tumor who presented with retroperitoneal, mediastinal, and pulmonary metastases after chemotherapy. Forty months after his original diagnosis, a mediastinal angiosarcoma was diagnosed. Using tissue microdissection–loss of heterozygosity analysis and fluorescence in situ hybridization, we analyzed the clonality of the primary germ cell tumor, angiosarcoma, and metastatic teratoma. Six microsatellite polymorphic markers from 3 different chromosomes were used to examine the pattern of allelic loss; chromosome 12p alterations, including isochromosome 12p and 12p overrepresentation, were investigated. Loss of heterozygosity was demonstrated for microsatellite loci of all 3 chromosomes, and completely concordant loss of heterozygosity patte...

Treatment and Outcomes in Adult Patients with Primary Cardiac Sarcoma: The British Columbia Cancer Agency Experience

Annals of Surgical Oncology — Thu, 15 Oct 2009 05:55:42 +0100

Conclusions Patients with nonmetastatic cardiac sarcoma amenable to complete resection experienced improved survival. However, the high overall rates of disease progression and mortality highlight the need for more effective local and systemic treatments that may be used in conjunction with surgery to improve patient outcomes. Content Type Journal ArticleCategory Bone and Soft Tissue SarcomasDOI 10.1245/s10434-009-0734-8Authors Pauline T. Truong, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaStuart O. Jones, British Columbia Cancer Agency Radiation Therapy Program, Vancouver Island Centre Victoria BC CanadaBenjamin Martens, University of British Columbia Vancouver BC CanadaCheryl Alexander, British Columbia Cancer ...

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Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides

Cancer Science — Mon, 12 Oct 2009 00:00:00 +0100

Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were carried out on non-tumorous liver sections from Thorotrast-induced ICC (T-ICC) and Thorotrast-induced AS (T-AS). Autoradiography revealed that the slope of the regression...

A Case of Primary Cardiac Angiosarcoma: Extensive Right Atrial Wall Reconstruction with Autologous Pericardium

Journal of Cardiac Surgery — Sun, 11 Oct 2009 23:00:00 +0100

We report the case of a 48-year-old man affected by angiosarcoma of the right atrium who presented with subacute cardiac tamponade. Extensive resection of the atrial wall infiltrated by the tumor, followed by autologous pericardial free atrial wall reconstruction, was successfully carried out. In spite of the optimal early outcome, the patient died 15 months later because of multiple osteal metastases. (J Card Surg ****;**:**-**) (Source: Journal of Cardiac Surgery)

[Microdialysis monitoring of a free omentum flap.]

Revue de Stomatologie et de Chirurgie Maxillo-Faciale — Sun, 11 Oct 2009 23:00:00 +0100

We report an application on a greater omentum free flap. CASE REPORT: A 77 year old female patient was operated for a vertex angiosarcoma. A large loss of vertex substance (175cm(2)) was rebuilt with a greater omentum free flap. Monitoring included hourly clinical observation (color, temperature, aspect), and flap surveillance using microdialysis CMA 60((R)) catheter. The first value was obtained 1h 30 after revascularization. The following recordings were made every hour for 48hours, then every 2hours for the next two days, then every 4hours. The following parameters were assessed: glucose (G), lactate (L), and pyruvate (P). The lactate/pyruvate (L/P) ratio was calculated after each dosage. Critical and alert values were the same as for other types of flaps. The first values for G, L, P, ...

Epithelioid angiosarcoma: A neoplasm with potential diagnostic challenges

Diagnostic Cytopathology — Tue, 06 Oct 2009 23:00:00 +0100

In this report, the patient is a 24-year-old man presenting with testicular pain, a pelvic mass, and innumerable liver nodules. Immediate interpretation of the needle core biopsies of the pelvic mass and liver lesions initially favored a poorly differentiated adenocarcinoma. Unusual positive immunohistochemical stains for CD30 and CK7 ultimately led the investigation toward a tumor of mesenchymal origin. Further, immunohistochemical evaluation demonstrated positive CD31 and Factor VIII staining and established the final diagnosis of epithelioid angiosarcoma. The tumor cells were negative for CD34, CK20, alpha-fetoprotein, placental-like alkaline phosphatase, hepatocyte paraffin 1, polyclonal carcinoembryonic antigen, CD10, CA-125, prostate-specific antigen, and prostatic acid phosphatase. ...

Angiosarcoma of skull base in a 1-year-old child—A case report

International Journal of Pediatric Otorhinolaryngology — Mon, 05 Oct 2009 16:38:51 +0100

Abstract: Angiosarcoma is a rare tumour of endothelial cell origin whilst malignant skull base tumours are highly unusual in paediatric patients. This case reports an angiosarcoma involving the clivus and basi-sphenoid region of the skull base, in a 1-year-old boy. This tumour is extremely rare in childhood, particularly in this site. The histological features were consistent with a high-grade haemangioendothelioma, categorised as an angiosarcoma [1]. The characteristics of this rare malignancy and the challenges in its management are discussed. This is the youngest reported patient, to our knowledge, with an angiosarcoma of the skull base. (Source: International Journal of Pediatric Otorhinolaryngology)

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Vinyl chloride and the liver

Journal of Hepatology — Thu, 01 Oct 2009 00:00:00 +0100

Vinyl chloride monomer is a known cause of angiosarcoma of the liver. It also has other toxic effects on the liver, and it has recently been suggested that exposure to vinyl chloride also causes hepatocellular carcinoma. However, the data on which this conclusion is based is incomplete. There is inadequate ascertainment of unequivocal diagnoses. In the largest studies lack of data meant that confounding diseases such as viral hepatitis or alcoholic liver disease could not be assessed. At best, the increase in risk is minimal, based on more than 22,000 exposed workers and more than 640,000 person years of observation.However, based on the available data the hypothesis that vinyl chloride causes or contributes to the development of hepatocellular carcinoma remains unproven. (Source: Journal ...

Hypervascular Liver Lesions

Seminars in Ultrasound CT and MRI — Wed, 23 Sep 2009 17:19:18 +0100

Hypervascular hepatocellular lesions include both benign and malignant etiologies. In the benign category, focal nodular hyperplasia and adenoma are typically hypervascular. In addition, some regenerative nodules in cirrhosis may be hypervascular. Malignant hypervascular primary hepatocellular lesions include hepatocellular carcinoma, fibrolamellar carcinoma, and peripheral cholangiocarcinoma. Vascular liver lesions often appear hypervascular because they tend to follow the enhancement of the blood pool; these include hemangiomas, arteriovenous malformations, angiosarcomas, and peliosis. While most gastrointestinal malignancies that metastasize to the liver will appear hypovascular on arterial and portal-venous phase imaging, certain cancers such as metastatic neuroendocrine tumors (includ...

Rectal Angiosarcoma After Adjuvant Chemoradiotherapy for Adenocarcinoma of the Rectum [DIAGNOSIS IN ONCOLOGY]

Journal of Clinical Oncology — Sun, 20 Sep 2009 23:00:00 +0100

(Source: Journal of Clinical Oncology)

Hematuria: The Presenting Symptom of an Angiosarcoma of the Inferior Vena Cava

The Journal of Urology — Wed, 16 Sep 2009 23:00:00 +0100

A 41-year-old white male experienced 3 episodes of gross hematuria in 2 weeks. With the exception of nonspecific and nonlocalized abdominal discomfort the patient claimed to be asymptomatic. However, he had noticed an unintentional weight loss of approximately 15 lbs during the last 9 months. (Source: The Journal of Urology)

Cardiac and gingival metastasis after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelioid angiosarcoma: case report and review of the literature

Gynecological Surgery — Wed, 16 Sep 2009 18:51:59 +0100

We present a unique case of cardiac and gingival metastases developing 4 years after total abdominal hysterectomy with bilateral salpingo-oophorectomy for primary uterine epithelial angiosarcoma. Initial treatment remains total abdominal hysterectomy with bilateral salpingo-oophorectomy. Limited distant metastases may be surgically resected in selected cases in order to improve quality of life or to prevent sudden death in untreated patients. Optimal chemotherapy regimens must be determined. Content Type Journal ArticleCategory CommunicationDOI 10.1007/s10397-009-0514-2Authors Olivier Donnez, Cliniques Universitaires de Mont-Godinne Department of Gynecology 5530 Yvoir BelgiumEtienne Marbaix, Université Catholique de Louvain Department of Anatomopathology 1200 Brussels Belgiu...

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KDR Activating Mutations in Human Angiosarcomas Are Sensitive to Specific Kinase Inhibitors

Cancer Research — Sun, 13 Sep 2009 23:00:00 +0100

Angiosarcomas (AS) represent a heterogeneous group of malignant vascular tumors occurring not only in different anatomic locations but also in distinct clinical settings, such as radiation or associated chronic lymphedema. Although representing only 1% to 2% of soft tissue sarcomas, vascular sarcomas provide unique insight into the general process of tumor angiogenesis. However, no molecular candidates have been identified to guide a specific therapeutic intervention. By expression profiling, AS show distinct up-regulation of vascular-specific receptor tyrosine kinases, including TIE1, KDR, SNRK, TEK, and FLT1. Full sequencing of these five candidate genes identified 10% of patients harboring KDR mutations. A KDR-positive genotype was associated with strong KDR protein expression and was r...

Cytogenetic analysis of a primary bone angiosarcoma

Cancer Genetics and Cytogenetics — Mon, 07 Sep 2009 17:31:17 +0100

We report a case of primary bone angiosarcoma, arising in the tibia of a 79-year-old woman, with a unique clonal chromosomal rearrangement: t(1;14)(p21;q24), that has not been reported in either soft tissue or primary bone angiosarcoma. The biologic significance of this translocation is not clear; however, the 1p21 locus is in the region of colony stimulating factor (CSF-1), which may play a role in tumorigenesis, as has been described in pigmented villonodular synovitis and tenosynovial giant cell tumor. (Source: Cancer Genetics and Cytogenetics)

[Original articles] Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature

Journal of Clinical Pathology — Thu, 03 Sep 2009 23:00:00 +0100

Conclusion: The diagnosis of MLL continues to be challenging, in particular for pathologists. Awareness of this entity, clinical correlation and gross pathological correlation are essential in the separation of this distinctive pseudosarcoma from its various morphological mimics. (Source: Journal of Clinical Pathology)

Outcome of Locally Recurrent and Metastatic Angiosarcoma

OncologySTAT Journal Scans — Tue, 01 Sep 2009 11:44:34 +0100

Locally recurrent AS is treatable, but outlook for metastatic AS is favorable only with isolated lymphatic spread and taxol treatment. Background. Angiosarcoma (AS) is a rare soft tissue sarcoma with... (Source: OncologySTAT Journal Scans)

Palliative surgical treatment of primary cardiac angiosarcoma complicated with recurrent tamponade

Journal of Surgical Oncology — Sun, 30 Aug 2009 23:00:00 +0100

No Abstract. (Source: Journal of Surgical Oncology)

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[Images in Thorax] Small cell lung cancer mimicking a pulmonary venous angiosarcoma

Thorax — Thu, 27 Aug 2009 23:00:00 +0100

(Source: Thorax)

Cardiac Angiosarcoma with Cardiac Tamponade Diagnosed as a Ruptured Aneurysm of the Sinus Valsalva

Japanese Journal of Clinical Oncology — Wed, 26 Aug 2009 23:00:00 +0100

In this report, we describe the case of a 56-year-old woman with a right atrial angiosarcoma. The patient presented with impending cardiac tamponade caused by right atrial perforation, but was misdiagnosed as a ruptured aneurysm of the sinus valsalva based on findings of a continuous murmur and an aorta to right atrium shunt by echocardiography. In the emergent operation that ensued, we found a right atrial perforation and a right coronary artery fistula to the right atrium. Coronary artery fistula is a rare complication of primary cardiac angiosarcoma, and a continuous murmur is also extremely rare as a clinical finding of angiosarcoma. We report the case and review the literature. (Source: Japanese Journal of Clinical Oncology)

Aortic angiosarcoma masquerading as a thoracic aortic aneurysm

Journal of Vascular Surgery — Tue, 25 Aug 2009 00:00:00 +0100

We report a case of aortic angiosarcoma masquerading as a descending thoracic aneurysm arising from a penetrating ulcer. The patient was initially treated with an endovascular stent graft for rapid growth, but the lesion continued to enlarge despite angiographic exclusion. FDG-PET CT scan and biopsy ultimately confirmed the diagnosis of aortic angiosarcoma. This case highlights some of the difficulties of making the early diagnosis of aortic angiosarcoma. (Source: Journal of Vascular Surgery)

[Pulmonary Ewing Sarcoma/Primitive Neuroectodermal Tumor: A Case Report and a Review of the Literature.]

Archivos de Bronconeumologia — Sun, 02 Aug 2009 23:00:00 +0100

We present the case of a 22-year-old woman with Ewing sarcoma/PNET diagnosed following histologic, immunohistochemical, and in situ hybridization studies of a bronchial biopsy specimen. Radiography, ventilation-perfusion scintigraphy, and a bone marrow biopsy confirmed that the tumor was not metastatic. The patient was started on a chemotherapy regimen of vincristine, actinomycin, cyclophosphamide, doxorubicin, ifosfamide, and etoposide and responded well. She is now being seen regularly at our outpatient clinic. PMID: 19656607 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)

Postradiation cutaneous vascular tumors of the breast: a review

Seminars in Diagnostic Pathology — Sat, 01 Aug 2009 00:00:00 +0100

Postradiation vascular tumors fall into two categories: (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner. Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists. Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial. It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process. This latter view point is supported by the significant cl...

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Pseudoangiomatous stromal hyperplasia of the breast.

Archives of Pathology and Laboratory Medicine — Fri, 31 Jul 2009 23:00:00 +0100

Authors: AbdullGaffar B Pseudoangiomatous stromal hyperplasia is a relatively common lesion of the breast. In general, it is less commonly found as a clinically palpable mass and is more commonly found as incidental microscopic foci. It is a benign proliferative, probably neoplastic, hormonally driven process of the mammary stromal myofibroblasts. The clinical, radiologic, and cytologic findings can resemble those of fibroadenoma. Histologically, it can be confused with low-grade angiosarcoma. The exact etiology of pseudoangiomatous stromal hyperplasia is still controversial, but a neoplastic process of the stromal myofibroblasts, with a hormonal stimulus in its development and progression, is the favored theory. Most lesions can be cured by complete surgical excision, and patients und...

Angiosarcoma of the scalp

Indian Journal of Plastic Surgery — Thu, 30 Jul 2009 10:50:14 +0100

Manjiri Das Gupta, Nilay Chakrabarti, Pravin Agrawal, Swati NarurkarIndian Journal of Plastic Surgery 2009 42(1):118-121Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case of a 55-year-old female patient with a bleeding scalp lesion is presented. Initially thought to be a pyogenic granuloma, on excisional biopsy it was diagnosed as angiosarc...

Definition of the features of acquired elastotic hemangioma reporting the clinical and histopathological characteristics of 14 patients

Journal of Cutaneous Pathology — Mon, 13 Jul 2009 23:00:00 +0100

Conclusion: Acquired elastotic hemangioma is a distinctive variant of hemangioma which should be differentiated from other cutaneous vascular tumors with a hobnail endothelial pattern, including angiosarcoma. The expression of D2-40 in most cases suggests a lymphatic origin of this acquired vascular proliferation. (Source: Journal of Cutaneous Pathology)

Radiation-induced angiosarcoma following treatment of metastatic melanoma

Journal of Cutaneous Pathology — Sun, 12 Jul 2009 23:00:00 +0100

(Source: Journal of Cutaneous Pathology)

Primary hepatic angiosarcoma: imaging findings and palliative treatment with transcatheter arterial chemoembolization or embolization

Clinical Radiology — Thu, 09 Jul 2009 11:34:06 +0100

Conclusions: Primary hepatic angiosarcoma appears as a solitary or multiple, hypervascular lesions with heterogeneously early and progressive enhancement on CT and angiography. Although TAE may be the primary procedure for achieving emergent bleeding control caused by the rupture of hepatic angiosarcomas, TACE may be effective for treating patients with a dominant hepatic angiosarcoma with or without intrahepatic metastases. (Source: Clinical Radiology)

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Thrombocytopenia as first manifestation of splenic angiosarcoma

Annals of Hematology — Wed, 01 Jul 2009 06:13:18 +0100

Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s00277-009-0778-7Authors Simon Raffel, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyBert Hildebrandt, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin GermanyChristian Grieser, Charité Campus Virchow Klinikum Department of Radiology Augustenburger Platz 1 13353 Berlin GermanyStefan Pahl, Charité Campus Mitte Institute of Pathology Charitéplatz 1 10117 Berlin GermanyIsrid Sturm, Charité Campus Virchow Klinikum Department of Hematology and Oncology Augustenburger Platz 1 13353 Berlin Germany Journal Annals of HematologyOnline ISSN 1432-0584Print ISSN 0939-5555 (Source: Annals of Hemat...

Postoperative outcomes in intimal aortic angiosarcoma: A case report and review of the literature

Journal of Vascular Surgery — Mon, 29 Jun 2009 16:07:47 +0100

We present the case of a 74-year-old woman with intimal angiosarcoma that manifested with the triad of congestive heart failure, acute renal failure, and abdominal angina. A review of the literature and discussion of postoperative outcomes follows. (Source: Journal of Vascular Surgery)

Angiosarcoma of the scalp

Indian Journal of Plastic Surgery — Mon, 29 Jun 2009 15:07:33 +0100

Gupta Manjiri Das, Chakrabarti Nilay, Agrawal Pravin, Narurkar SwatiIndian Journal of Plastic Surgery 2009 42(1):118-121Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case of a 55-year-old female patient with a bleeding scalp lesion is presented. Initially thought to be a pyogenic granuloma, on excisional biopsy it was diagnosed as angiosarc...

[Sarcomas] Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas

Journal of Clinical Oncology — Sun, 28 Jun 2009 23:00:00 +0100

Conclusion As a single agent, sorafenib has activity against angiosarcoma and minimal activity against other sarcomas. Further evaluation of sorafenib in these and possibly other sarcoma subtypes appears warranted, presumably in combination with cytotoxic or kinase-specific agents. (Source: Journal of Clinical Oncology)

[Sarcomas] Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model

Journal of Clinical Oncology — Sun, 28 Jun 2009 23:00:00 +0100

Conclusion This is the first phase II study of a new agent in sarcoma to include sufficient patients with each of the common histologic subtypes to permit generalizable conclusions. The BHM is an effective method for studying rare diseases and their subtypes, when it is reasonable to assume that their response rates are exchangeable. Although rare dramatic responses were seen, imatinib is not an active agent in advanced sarcoma in these subtypes. (Source: Journal of Clinical Oncology)

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Phase II Study of Sorafenib in Patients With Metastatic or Recurrent Sarcomas [Sarcomas]

Journal of Clinical Oncology — Sun, 28 Jun 2009 23:00:00 +0100

Phase II Multicenter Trial of Imatinib in 10 Histologic Subtypes of Sarcoma Using a Bayesian Hierarchical Statistical Model [Sarcomas]

Journal of Clinical Oncology — Sun, 28 Jun 2009 23:00:00 +0100

Outcome of Locally Recurrent and Metastatic Angiosarcoma

Annals of Surgical Oncology — Wed, 24 Jun 2009 06:08:20 +0100

Conclusion Locally recurrent AS is often treatable; complete resection can potentially prolong survival. In contrast, metastatic patients have a grave prognosis; however, patients with isolated lymphatic spread and possibly those treated with taxol-based chemotherapeutic regimens have a favorable outcome. Content Type Journal ArticleCategory Gastrointestinal OncologyDOI 10.1245/s10434-009-0569-3Authors G. Lahat, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAA. R. Dhuka, University of Texas MD Anderson Cancer Center Department of Surgical Oncology Houston TX USAS. Lahat, The Sarcoma Research Center, University of Texas MD Anderson Cancer Center Houston TX USAK. D. Smith, University of Texas MD Anderson Cancer Center Departm...

Granular cell atypical fibroxanthoma: case report and review of the literature

Journal of Cutaneous Pathology — Wed, 17 Jun 2009 04:00:00 +0100

We present a case of granular cell atypical fibroxanthoma of the scalp. The neoplasm occurred as a tender nodule on the frontal scalp of an 82-year-old Caucasian man. Histology demonstrated a diffuse proliferation of atypical epithelioid cells with abundant granular cytoplasm. Many of the cells had large irregular nuclei and atypical mitotic figures were present. Immunohistochemical stains were positive for CD68 and procollagen 1 and negative for cytokeratin, HMB-45 and S-100 protein. The granular cell phenotype has been observed in other cutaneous neoplasms including granular cell tumors, dermatofibromas, dermatofibrosarcoma protuberans, fibrous papules, basal cell carcinomas, leiomyosarcomas, angiosarcomas and primitive polypoid granular cell tumors. We discuss the differential diagnosis...

Secondary sarcomas after radiotherapy for breast cancer

Cancer — Fri, 12 Jun 2009 04:00:00 +0100

The objective of the current study was to quantify the risk of STS after RT and surgery for breast cancer (BCa), assess time trends, and compare long-term survival of patients with RT-associated and non-RT-associated angiosarcoma (AS) using the Surveillance, Epidemiology, and End Results (SEER) database.Women with BCa reported to SEER in 1973 to 2003 were included. Kaplan-Meier curves and proportional hazards models, reported as hazards ratios (HR) with 95% confidence intervals (95% CI), were used. Survival of patients who developed RT-associated AS was compared with that of patients with primary AS of the thorax and upper extremities.The cohort of 563,155 BCa patients was divided into 2 groups: those who received RT (37%) and those who received no RT. RT use increased with time (P 20 year...

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[CASE STUDIES] Pulmonary Angiosarcoma Presenting as Spontaneous Recurrent Hemothorax

Asian Cardiovascular and Thoracic Annals — Wed, 10 Jun 2009 04:00:00 +0100

An incidental diagnosis of pulmonary angiosarcoma was made after surgical exploration for repeated episodes of bleeding in an 85-year-old woman. Spontaneous hemothorax is uncommon and deserves detailed investigation. (Source: Asian Cardiovascular and Thoracic Annals)

Pulmonary Angiosarcoma Presenting as Spontaneous Recurrent Hemothorax [CASE STUDIES]

Asian Cardiovascular and Thoracic Annals — Tue, 09 Jun 2009 23:00:00 +0100

Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib

Sarcoma — Tue, 09 Jun 2009 15:10:54 +0100

A 52 year-old woman presented with an incidentally detected retroperitoneal angiosarcoma and multiple hepatic metastases. After chemotherapy with weekly paclitaxel and doxorubicin, angiosarcoma had progressed rapidly. Because few chemotherapeutic options were available for her, sunitinib (37.5 mg/day, daily) as a salvage regimen was administered. Although sunitinib was interrupted after two weeks due to hematologic abnormalities, some metastatic nodules were regressed. Therefore, sunitinib was recommenced at a reduced dose (25 mg/day, daily). Serial computed tomography scans showed variable response in each tumor, however, sunitinib at least delayed tumor progression, compared to previous chemotherapy. With this case report, we suggest sunitinib may be effective against angio...

Spontaneous Regression of Pulmonary Metastases from Breast Angiosarcoma

Sarcoma — Tue, 09 Jun 2009 15:10:54 +0100

We present a rare case of pulmonary metastases in a 72-year-old woman with metastatic breast angiosarcoma. She was diagnosed with a breast angiosarcoma in 2005 and underwent a total mastectomy and postoperative radiotherapy. Unfortunately, a year later she was found to have multiple lung and scalp metastases but in a view of her poor general fitness, she was not a candidate for chemotherapy and was kept on regular followup. Despite the absence of any treatment, the followup chest X-ray showed a significant reduction in the number and size of lung nodules and her scalp lesions regressed completely. Seven months after the diagnosis of metastatic disease, the nodules in her scalp remain controlled. (Source: Sarcoma)

UNC scientists identify growth factor as possible cancer drug target

EurekAlert! - Cancer — Tue, 09 Jun 2009 04:00:00 +0100

(University of North Carolina School of Medicine) Scientists at the UNC Lineberger Comprehensive Cancer Center report finding a new angiogenesis protein, SFRP2, found in the blood vessels of numerous tumor sites, including breast prostate, lung, pancreas, ovarian, colon, kidney tumors and angiosarcomas. (Source: EurekAlert! - Cancer)

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Secreted Frizzle-Related Protein 2 Stimulates Angiogenesis via a Calcineurin/NFAT Signaling Pathway

Cancer Research — Mon, 01 Jun 2009 04:00:00 +0100

In conclusion, SFRP2 is a novel stimulator of angiogenesis that stimulates angiogenesis via a calcineurin/NFAT pathway and may be a favorable target for the inhibition of angiogenesis in solid tumors. [Cancer Res 2009;69(11):4621–8] (Source: Cancer Research)

Skin cancer

Medicine — Mon, 01 Jun 2009 04:00:00 +0100

Abstract: Skin cancer is the most common cancer worldwide. Skin cancers most often arise from the epidermis (basal cell carcinoma and squamous cell carcinoma), but cancer may arise from any structure in the skin, including from the melanocytes (melanoma), blood vessels (e.g. angiosarcoma), adnexal structures (e.g. malignant sweat gland tumours) and the connective tissue (e.g. dermatofibrosarcoma protuberans). The skin can also be the site of lymphoma and metastasis from internal cancers, including carcinoma of the breast, colon and lung. This contribution focuses on the most common skin cancers: melanoma and the ‘non-melanoma’ skin cancers (squamous cell carcinoma and basal cell carcinoma), and briefly discusses infiltration of the skin with lymphoma. (Source: Medicine)

[Primary breast angiosarcoma: Two cases report.]

Cancer Radiotherapie — Sun, 31 May 2009 23:00:00 +0100

Authors: Champeaux-Orange E, Bonneau C, Raharimanana B, Favre A, Ibrahim M, Breteau N Primary angiosarcoma is a rare type of breast cancer, the diagnosis is difficult to establish and it has the worst prognostic of all breast malignancies. Two cases of primary breast angiosarcoma have been observed at the centre Henry Kaplan of Tours and at the hospital La Source of Orleans since 2001. Based on a literature review, we analyse the epidemiological, pathological, clinical, diagnostic and treatment aspect of this type of cancer. Mastectomy is the reference treatment and the benefit of radiotherapy and chemotherapy remains to be demonstrated. PMID: 19410492 [PubMed - in process] (Source: Cancer Radiotherapie)

[Primary angiosarcoma of the liver.]

Korean J Hepatol — Sun, 31 May 2009 23:00:00 +0100

Authors: Seok JY, Kim YB PMID: 19581774 [PubMed - in process] (Source: Korean J Hepatol)

Detecting angiosarcoma: Case study underscores importance of quick, accurate diagnosis

Modern Medicine — Sat, 30 May 2009 17:32:36 +0100

A quick and accurate diagnosis of angiosarcoma, followed by decisive treatment with a multidisciplinary approach can help avoid regional and distant metastases of the tumor and lead to a favorable prognosis, one expert says. (Source: Modern Medicine)

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Primary angiosarcoma of the abdominal aorta: multi-row computed tomography

Abdominal Imaging — Fri, 22 May 2009 06:48:47 +0100

We report on interventional and CT-angiographic features of an abdominal aortic angiosarcoma, observed in a 71-year-old patient. The polyploid intimal alteration is clearly depicted on CT images. Morphology and the segmental obstruction of the aortic lumen without aneurysmal or extensive atherosclerotic mural changes should lead to the differential diagnosis of an intravascular malignancy. Content Type Journal ArticleDOI 10.1007/s00261-009-9537-4Authors Leopold Winter, Charite Medical University Center, Campus Virchow Clinic Department of Radiology Augustenburger Platz 1 13353 Berlin GermanyJan Langrehr, Charite Medical University Center, Campus Virchow Clinic Department of General, Visceral and Transplant Surgery Augustenburger Platz 1 13353 Berlin GermanyEnrique Lopez Hänninen, ...

Imprint cytology of primary cardiac sarcomas: a report of 3 cases

Annals of Diagnostic Pathology — Thu, 21 May 2009 23:00:00 +0100

This study elucidated the cellular characteristics and immunohistochemistry for cardiac sarcomas using imprint smears as an aid to cytopathologic diagnosis. (Source: Annals of Diagnostic Pathology)

Angiosarcoma in children – still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study

European Journal of Cancer Care — Thu, 21 May 2009 04:00:00 +0100

BIEN E., STACHOWICZ-STENCEL T., BALCERSKA A., GODZINSKI J., KAZANOWSKA B., PEREK-POLNIK M., MADZIARA W., RYBCZYNSKA A., KURYLAK A., ZALEWSKA-SZEWCZYK B. & PEREGUD-POGORZELSKI J. (2009) European Journal of Cancer CareAngiosarcoma in children [ndash] still uncontrollable oncological problem. The report of the Polish Paediatric Rare Tumours Study Angiosarcoma is a rare, highly malignant vascular neoplasm with little data available on its clinical course and management in children. Ten children with angiosarcoma (M/F: 6/4; aged 2, 3[ndash]16 years) registered in Polish Paediatric Rare Tumours and Soft Tissue Sarcomas Studies between 1992 and 2006. Primary tumour exceeded 5 cm in seven patients and affected mainly deep tissues (heart-2, head/neck, bladder, brain, liver and upper limb [ndash] on...

Angiosarcoma of the Retroperitoneum: Report on a Patient Treated with Sunitinib

Sarcoma — Wed, 20 May 2009 23:46:15 +0100

[Intravascular papillary endothelial hyperplasia of the ankle: A case report.]

Annales de Chirurgie Plastique et Esthetique — Mon, 11 May 2009 23:00:00 +0100

We report a case of cutaneous IPEH in the ankle of a 30-year-old girl, which was successfully treated by excision. The pathologic findings, differential diagnosis and a review of recent literature are discussed. PMID: 19443095 [PubMed - as supplied by publisher] (Source: Annales de Chirurgie Plastique et Esthetique)

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Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution

European Journal of Surgical Oncology — Sun, 10 May 2009 15:32:52 +0100

Conclusion: RIS is a biologically aggressive tumour with high rates of local relapse despite aggressive attempts at curative surgery. (Source: European Journal of Surgical Oncology)

Angiosarcomas of the head and neck: a clinico-immunohistochemical study of 8 consecutive patients

International Journal of Oral and Maxillofacial Surgery — Fri, 01 May 2009 04:00:00 +0100

Background and Objectives: Angiosarcoma (AS), also known as malignant haemangioendothelioma, is a rare and aggressive malignant vascular tumour, the cells of which variably recapitulate the morphology and functional features of normal endothelium. Few than 5% of all soft tissue sarcomas occur in the head and neck, and only about 10% of them are ASs. The purpose of this study is to determine the biological behaviour of ASs of head and neck, and describe their morphologic and immunohistochemical features. (Source: International Journal of Oral and Maxillofacial Surgery)

Aortic angiosarcoma with cutaneous metastases.

Vascular — Thu, 30 Apr 2009 23:00:00 +0100

We present a case of primary aortic angiosarcoma presenting with intermittent claudication and radiologic findings of aortoiliac atherosclerotic disease treated initially with stenting; lower extremity embolic skin metastases developed during follow-up that prompted resection of the aortic bifurcation and restoration of the arterial continuity with a bypass. Despite postresection recurrence, a 3-year survival was achieved with aggressive multidisciplinary management. PMID: 19476753 [PubMed - in process] (Source: Vascular)

Hepatic angiosarcoma: a rare liver tumor in a hemodialysis patient.

Clinical Nephrology — Thu, 30 Apr 2009 23:00:00 +0100

Authors: Matsumoto M, Tamura M, Komiya T, Aridome G, Narita R, Hisaoka M, Ohtsuki M, Otsuji Y PMID: 19473625 [PubMed - in process] (Source: Clinical Nephrology)

Primary angiosarcoma of the ovary complicated by hemoperitoneum: a case report and review of the literature

Archives of Gynecology and Obstetrics — Sat, 25 Apr 2009 07:28:03 +0100

Conclusion Primary ovarian angiosarcoma is extremely rare, often presenting in later stages with nonspecific symptoms. Immunohistochemical staining of pathological specimens can aid in the diagnosis. The optimal regimen for adjuvant chemotherapy is unknown, and the prognosis is very poor. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1092-2Authors Leslie Bradford, University of Wisconsin Hospital and Clinics Department of Obstetrics and Gynecology 600 Highland Ave, H4/648 Madison WI 53703 USAKathryn Swartz, Meriter Hospital Department of Pathology Madison WI USAStephen Rose, University of Wisconsin Hospital and Clinics Department of Obstetrics and Gynecology 600 Highland Ave, H4/648 Madison WI 53703 USA Journal Archives of Gynecology an...

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Pancoast tobias syndrome revealing primary epithelioid pleuro-pericardial angiosarcoma: A case report and review of the literature

Indian Journal of Thoracic and Cardiovascular Surgery — Sat, 25 Apr 2009 07:23:11 +0100

We report a unique case of primary epithelioid angiosarcoma of the pleura and the pericardium in a 28-year-old man who was admitted for Pancoast Tobias syndrome. Thoracoscopy revealed a multifocal neoplasm and pleural biopsy showed a malignant tumor which histological and immunophenotypical features were characteristic of epithelioid angiosarcoma. Content Type Journal ArticleDOI 10.1007/s12055-009-0009-9Authors Coulibaly Béma, CHU Timone Service d’Anatomie pathologique et de Neuropathologie 264 rue Saint Pierre 13385 Marseille cedex 05 FrancePayan Marie-José, CHU Timone Service d’Anatomie pathologique et de Neuropathologie 264 rue Saint Pierre 13385 Marseille cedex 05 FranceThomas Pascal, Hôpital Sainte Marguerite Service de Chirurgie thoracique et des maladies de l’œsopha...

Sinonasal intravascular papillary endothelial hyperplasia successfully treated by endoscopic excision: A case report and review of the literature

Auris, Nasus, Larynx — Fri, 24 Apr 2009 13:26:56 +0100

Conclusions: IPEH may be mistaken for an angiosarcoma clinically and histopathologically. Complete endoscope-guided surgical excision is the best choice of therapy for patients with IPEH and is both diagnostic and curative. Awareness of this lesion will prevent incorrect diagnosis and overly aggressive treatment. (Source: Auris, Nasus, Larynx)

Right atrial angiosarcoma and electrocardiogram-gated cardiac computed tomography: a case report

The Chinese-German Journal of Clinical Oncology — Tue, 21 Apr 2009 10:07:09 +0100

In this report, a patient presented with chest distress and shortness of breath after activity. Echocardiography of other hospital showed a hyperechoic right atrial mass. Electrocardiogram-gated cardiac computed tomography (ECG-Gated CT) of our hospital provided accurate information about the site and extent of the tumor, and the involvement of neighboring structures, even about the malignant nature of the lesion. The pathological study indicated angiosarcoma. The role of ECG-Gated CT in the assessment of cardiac masses and tumors was discussed. Cardiac tumors are extremely rare and can be divided into benign and malignant lesions. Myxomas are the most common type of cardiac benign tumor, while angiosarcomas are the most common type of cardiac malignant tumor. Imaging studies play a...

ORIGINAL ARTICLE: Long-term Survival After Surgery for Primary Hepatic Sarcoma in Adults

Archives of Surgery — Mon, 20 Apr 2009 04:00:00 +0100

Conclusions Although primary hepatic sarcoma is a rare malignant tumor, no standard treatment is established. A long-term survival is possible after complete tumor resection in a preselected population with early-stage disease. (Source: Archives of Surgery)

Treatment of Vascular Soft Tissue Sarcomas With Razoxane, Vindesine, and Radiation

International Journal of Radiation Oncology * Biology * Physics — Thu, 09 Apr 2009 14:47:01 +0100

Conclusions: This trimodal treatment leads to excellent response rates, and it suppresses distant metastases when given as maintenance therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)

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Angiosarcoma of the breast: a clinicopathologic analysis of cases from the last 10 years

Annals of Diagnostic Pathology — Thu, 02 Apr 2009 04:00:00 +0100

In conclusion, breast angiosarcoma remains a rare disease. Rosen's method for grading breast angiosarcoma is easy to implement and correlates well with clinical outcome. There are no distinct clinical or histologic differences between primary and postradiation breast angiosarcomas. (Source: Annals of Diagnostic Pathology)

Promontory Sign-Present in Patch and Plaque Stage of Angiosarcoma!

The American Journal of Dermatopathology — Thu, 26 Mar 2009 16:42:45 +0100

Page: 132DOI: 10.1097/DAD.0b013e3181951045Authors: Lazova, Rossitza MD *; McNiff, Jennifer M MD *; Glusac, Earl J MD *; Godic, Aleksandar MD, PhD + (Source: The American Journal of Dermatopathology)

Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma

Annals of Oncology — Wed, 25 Mar 2009 04:00:00 +0100

Conclusions: A combination of chemotherapy resulted in an improved outcome for two of four patients, suggesting the potential usefulness of palliative chemotherapy to improve survival. This case study may aid in planning chemotherapy for patients with advanced hepatic angiosarcoma. (Source: Annals of Oncology)

Angiosarcoma of the Scalp: A Case Report and Review of Current and Novel Therapeutic Regimens

Dermatologic Surgery — Tue, 24 Mar 2009 04:00:00 +0100

The authors have indicated no significant interest with commercial supporters. (Source: Dermatologic Surgery)

Infantile hemangioendothelioma: A case report and discussion.

Pathology, Research and Practice — Mon, 23 Mar 2009 04:00:00 +0100

We report on a patient, male/2 years, who had two jejunal masses and a hepatic mass accompanied by lower GI bleeding and intestinal obstruction. The two jejunal masses and the hepatic lesion were diagnosed as angiosarcoma histomorphologically (IHHE type II), and were positive for vascular markers (CD31 and CD34) on immunohistochemistry. The patient had no skin lesions. We report this case and provide a literature review because of the unusual presentation and the overall rarity of this entity. PMID: 19321270 [PubMed - as supplied by publisher] (Source: Pathology, Research and Practice)

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Primary angiosarcoma of the thyroid gland with recurrence diagnosed by fine needle aspiration: A case report

Diagnostic Cytopathology — Sat, 21 Mar 2009 04:00:00 +0100

We describe a case of primary angiosarcoma of the thyroid in a 48-year-old female, who presented with a rapidly enlarging neck mass associated with compressive symptoms. She had a history of hypothyroidism. The initial fine needle aspiration cytology of the neck mass was negative. She then underwent left hemithyroidectomy. Histologically, the tumor showed poorly differentiated malignant cells with eccentrically-placed nuclei, prominent nucleoli, and intracytoplasmic vacuoles admixed with mixed inflammatory cells. These showed immunopositivity for CD31 but were negative for CD34, Factor VIII, CK5/6, EMA, TTF-1, Thyroglobulin, Calcitonin, Melan A, and Calretinin. A diagnosis of poorly differentiated malignant tumor consistent with angiosarcoma was made. The patient was treated with radiation...

Widespread cutaneous angiosarcoma of the scalp: diagnosis and soft tissue reconstruction with a combined double-muscle-free flap and split-thickness-skin graft

Oral and Maxillofacial Surgery — Fri, 20 Mar 2009 10:41:49 +0100

Conclusion This kind of treatment can be recommended because the early reconstruction allowed a soon adjuvant radiotherapy, and the patient regained a good quality of life due to the pleasant and aesthetically result. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s10006-009-0147-7Authors Eva Gudewer, Klinikum Oldenburg gGmbH, Clinic for Maxillofacial Surgery and Plastic Surgery Rahel-Straus-Str. 10 26133 Oldenburg GermanyErhard Hölzle, Klinikum Oldenburg gGmbH, Clinic for Dermatology and Allergology Rahel-Straus-Str. 10 26133 Oldenburg GermanyLei Li, Klinikum Oldenburg gGmbH, Clinic for Maxillofacial Surgery and Plastic Surgery Rahel-Straus-Str. 10 26133 Oldenburg Germany Journal Oral and Maxillofacial SurgeryOnline ISSN 1865-1569Print ISSN 1865-1...

Effective treatment of angiosarcoma on the nose by combination treatment with electron beam irradiation, recombinant interleukin-2 and docetaxel.

Clinical And Experimental Dermatology — Thu, 19 Mar 2009 04:00:00 +0100

Authors: Asano Y, Makino T, Furuichi M, Norisugi O, Shimizu T PMID: 19302586 [PubMed - as supplied by publisher] (Source: Clinical And Experimental Dermatology)

Angiosarcoma

About.com Breast Cancer — Sat, 07 Mar 2009 05:00:00 +0100

of the breast is a rarely diagnosed type of breast cancer. It can grow and spread quickly, and may affect many organs in your body. Learn the symptoms, tests to diagnose, and treatments for angiosarcoma of the breast. (Source: About.com Breast Cancer)

[Evidence-based radiotherapy in the treatment of early-stage invasive breast cancer: traditional risk factors and biomarkers.]

Magyar Onkologia — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Fodor J Adjuvant radiotherapy after modified radical mastectomy and breast-conserving surgery for early-stage invasive breast cancer substantially reduces the risk of locoregional failure and is evidence-based. Using traditional clinical and pathological factors, patients can be classified into subgroups by the risk of locoregional recurrence. In the high-risk groups the absolute benefit of irradiation is larger. However, the patients are over-treated in every subgroup. Substantial proportion of the patients remains free of locoregional recurrence even in the absence of irradiation, and some patients develop locoregional recurrence despite postoperative irradiation. Molecular markers may provide sufficient information to allow accurate individual risk assessment to identify pa...

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[Angiosarcoma.]

Korean J Hepatol — Sun, 01 Mar 2009 05:00:00 +0100

Authors: Lee WJ PMID: 19346792 [PubMed - in process] (Source: Korean J Hepatol)

Papules arising after radiotherapy for rhabdomyosarcoma.

Acta Dermatovenerologica Alpina, Panonica, et Adriatica — Sun, 01 Mar 2009 00:00:00 +0100

We describe a 50-year-old Caucasian woman with a past history of uterine rhabdomyosarcoma, treated 22 years prior with surgical excision, chemotherapy, and radiotherapy. She presented with a few skin-colored papules and a clear discharge located in the previously irradiated area (right inguinal region). Histopathology showed a proliferation of irregular, interanastomosing vascular channels, thin walled and lined by prominent endothelial cells with focally hobnail features. Cytological atypia of endothelial cells, mitotic figures, hemorrhagic areas, and necrosis were not observed. The endothelial cells expressed D2-40 and CD31. A diagnosis of BLAP following radiotherapy for uterine rhabdomyosarcoma was made. The patient was treated with complete excision using electrodessication. At the 20-...

Response to paclitaxel in a radiotherapy-induced breast angiosarcoma.

Acta Oncologica — Tue, 24 Feb 2009 05:00:00 +0100

Authors: Perez-Ruiz E, Ribelles N, Sanchez-Munoz A, Roman A, Marquez A PMID: 19235566 [PubMed - as supplied by publisher] (Source: Acta Oncologica)

Angiosarcoma in the aortic arch presented as repeat strokes

The Journal of Thoracic and Cardiovascular Surgery — Mon, 23 Feb 2009 00:00:00 +0100

A 51-year-old man visited a local medical clinic 4 weeks before admission because of a 6-month history of weight loss and anorexia. His medical history was unremarkable except for a blood pressure discrepancy in both arms on physical examination. Furthermore, a palpable abdominal mass was found and proved later to be a probable malignant adrenal tumor by means of abdominal computed tomographic analysis. (Source: The Journal of Thoracic and Cardiovascular Surgery)

Cutaneous epithelioid angiosarcoma: a neoplasm with potential pitfalls in diagnosis.

Journal of Cutaneous Pathology — Fri, 20 Feb 2009 08:41:17 +0100

We present five patients with cutaneous epithelioid angiosarcoma (EAS); in none, the clinical diagnosis included a vascular lesion. Three patients had history of breast conservation surgery with/without radiation therapy. Other patients had no previous radiation, and there was no lymphedema in any of the cases. The histopathological examination of the biopsy specimens by hematoxylin and eosin method was not suggestive of a malignant vascular neoplasm initially and the differential diagnoses included carcinoma, malignant melanoma and atypical lymphoid infiltrate. Only after performing immunohistochemical studies that included vascular markers, a definitive diagnosis was possible. Some cases showed unusual histopathological features. Cutaneous EAS is a rare variant of cutaneous AS that can m...

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Hemangioendothelioma of Urinary Bladder—Report of Rare Case

Urology — Fri, 20 Feb 2009 00:00:00 +0100

We report the clinical and pathologic findings of a case of primary epithelioid hemangioendothelioma of the urinary bladder in a 17-years-old boy. The tumor was treated by transurethral resection. (Source: Urology)

Hemangioendothelioma of Urinary Bladder-Report of Rare Case.

Urology — Thu, 19 Feb 2009 05:00:00 +0100

Angiosarcoma of the Kidney with Minute Clear Cell Carcinomas: A Case Report - Abstract

UroToday — Thu, 05 Feb 2009 23:00:00 +0100

Department of Pathology, The Jikei University School of Medicine, The Jikei Daisan Hospital, 4-11-1, Izumihoncho, Komaeshi, Tokyo 201-8601, Japan.... (Source: UroToday)

Angiosarcoma of the nasal cavity: a case report

Cases Journal — Thu, 29 Jan 2009 05:00:00 +0100

We present a 33-year-old male with spontaneous epistaxis that was refractory to cauterization. During physical examination a smooth purplish tumor of 1.5 cm x 1.5 cm was identified. A CT scan showed a nonenhanced tumor in the left nostril on the uncinate process. A biopsy revealed an intermediate-grade angiosarcoma. Surgical removal followed by radiation therapy was performed with good result. Aerodigestive angiosarcomas have a better prognosis than angiosarcomas of other locations due to better cell differentiation and the presence of early symptoms. Recurrence can occur because of tumor tissue left during resection. Our patient continues tumor free after three years. (Source: Cases Journal)

Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma.

Ann Oncol — Thu, 29 Jan 2009 05:00:00 +0100

CONCLUSIONS: A combination of chemotherapy resulted in an improved outcome for two of four patients, suggesting the potential usefulness of palliative chemotherapy to improve survival. This case study may aid in planning chemotherapy for patients with advanced hepatic angiosarcoma. PMID: 19179547 [PubMed - as supplied by publisher] (Source: Ann Oncol)

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Retiform hemangioendothelioma with lymph node metastasis: A rare entity

Indian Journal of Dermatology, Venereology and Leprology — Sun, 25 Jan 2009 03:52:23 +0100

Bhutoria Bhawna, Konar Abantika, Chakrabarti Sudipta, Das ShikhaIndian Journal of Dermatology, Venereology and Leprology 2009 75(1):60-62Retiform hemangioendothelioma (RH) is a rare, recently described, unique kind of low grade angiosarcoma. The tumor is characterized by distinctive arborizing blood vessels that mimic the appearance of rete testis. The tumor chiefly originates from the skin and subcutaneous tissue and has a tendency to recur locally. Only one case with lymph node metastasis has been reported previously. Another such rare case of RH is being reported in an adult female who presented with a subcutaneous nodule, underwent multiple recurrences and uniquely metastasized to regional lymph node. (Source: Indian Journal of Dermatology, Venereology and Leprology)

Angiosarcomas Arising in the Viscera and Soft Tissue of Children and Young Adults: A Clinicopathologic Study of 15 Cases.

The American Journal of Surgical Pathology — Sat, 24 Jan 2009 08:01:21 +0100

Page: 264DOI: 10.1097/PAS.0b013e3181875a5fAuthors: Deyrup, Andrea T. MD, PhD *; Miettinen, Markku MD +; North, Paula E. MD, PhD ++; Khoury, Joseph D. MD [S]; Tighiouart, Mourad PhD [//]; Spunt, Sheri L. MD [P]; Parham, David MD [sharp] **; Weiss, Sharon W. MD *; Shehata, Bahig M. MD * (Source: The American Journal of Surgical Pathology)

Retiform hemangioendothelioma with lymph node metastasis: A rare entity

Indian Journal of Dermatology, Venereology and Leprology — Thu, 22 Jan 2009 04:17:30 +0100

Bhutoria Bhawna, Konar Abantika, Chakrabarti Sudipta, Das ShikhaIndian Journal of Dermatology, Venereology and Leprology 2009 75(1):59-61Retiform hemangioendothelioma (RH) is a rare, recently described, unique kind of low grade angiosarcoma. The tumor is characterized by distinctive arborizing blood vessels that mimic the appearance of rete testis. The tumor chiefly originates from the skin and subcutaneous tissue and has a tendency to recur locally. Only one case with lymph node metastasis has been reported previously. Another such rare case of RH is being reported in an adult female who presented with a subcutaneous nodule, underwent multiple recurrences and uniquely metastasized to regional lymph node. (Source: Indian Journal of Dermatology, Venereology and Leprology)

FDG PET/CT Findings of Splenic Angiosarcoma.

Clinical Nuclear Medicine — Tue, 20 Jan 2009 06:49:11 +0100

Page: 82DOI: 10.1097/RLU.0b013e318192c4bfAuthors: Abe, Takashi MD *; Sato, Motohiro MD, PhD +; Okumura, Toshiyuki MD, PhD +; Shioyama, Yasukazu MD, PhD +; Mochizuki, Yasuaki MD, PhD ++; Yamashita, Hiroharu MD ++; Saito, Hitoaki MD, PhD [S]; Yoshimi, Fuyo MD, PhD ++ (Source: Clinical Nuclear Medicine)

Effectiveness of Preoperative PET Examination of Huge Angiosarcoma of the Heart.

Clinical Nuclear Medicine — Tue, 20 Jan 2009 06:49:11 +0100

Page: 99DOI: 10.1097/RLU.0b013e318192c3e3Authors: Higashiyama, Shigeaki MD, PhD; Kawabe, Joji MD, PhD; Hayashi, Takehiro MD, PhD; Kurooka, Hiroko MD, PhD; Oe, Ai MD, PhD; Kawamura, Etsushi MD, PhD; Shiomi, Susumu MD, PhD (Source: Clinical Nuclear Medicine)

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Malignant solitary fibrous tumors of the head and neck: A clinicopathological study of nine consecutive patients

Oral Oncology — Thu, 15 Jan 2009 00:00:00 +0100

Summary: Malignant solitary fibrous tumor (MSFT) is one of the angiosarcomas arising from or resembling the components of blood vessels. Because of its rarity, the diagnosis is difficult. Between 1998 and 2008, 24 patients were diagnosed as having hemangiopericytomas (16) and solitary fibrous tumors (8). Nine of them were confirmed to be MSFT and treated at the Department of Oral and Maxillofacial Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine. All patients were treated with surgery as the primary modality. Eight patients received postoperative adjuvant radiation therapy. The average follow-up duration was 4.6 years (range: 6 months–10 years). Of the nine patients reviewed in this study, three died of locoregional or distant metastasis, six survived ...

Metastatic Angiosarcoma in an Ileal Conduit: An Unusual Presentation

International Journal of Surgical Pathology — Wed, 14 Jan 2009 05:00:00 +0100

The authors in this study describe the case of a patient with a history of multiple malignancies who underwent total cystectomy with ileal loop urinary diversion and presented with a lower extremity angiosarcoma on the background of lymphedema a decade later. Shortly thereafter, she was diagnosed with metastatic ileal conduit angiosarcoma. The authors state that to their knowledge, this is the first case of ileal conduit angiosarcoma reported in the English literature. (Source: International Journal of Surgical Pathology)

Cardiac angiosarcoma: a case report and review of the literature.

Cardiovascular Pathology — Wed, 14 Jan 2009 05:00:00 +0100

We present the case of a 36-year-old woman with widespread metastatic cardiac angiosarcoma to the lungs and the liver. She was treated with preoperative chemotherapy and underwent extensive surgical resection of the cardiac mass and is currently doing well. Analysis of the effectiveness of various treatment modalities from cases which have been reported has also been reviewed and discussed. PMID: 19150248 [PubMed - as supplied by publisher] (Source: Cardiovascular Pathology)

Angiosarcoma of the kidney with minute clear cell carcinomas: A case report.

Pathology, Research and Practice — Tue, 13 Jan 2009 05:00:00 +0100

Authors: Fukunaga M A case of renal angiosarcoma with minute clear cell carcinomas in a 61-year-old male is described. The tumor was clinically considered a renal cell carcinoma. The lesion, removed by nephrectomy, was an unencapsulated hemorrhagic mass measuring 8.0cm in diameter. The tumor was histologically characterized by anastomosing vascular channels lined by cytologically atypical endothelial cells. The tumor cells reacted positively with CD31, factor-VIII related antigen, and CD34. A few minute clear cell carcinomas measuring less than 1mm were observed in the periphery of the angiosarcoma. There was no transition between angiosarcoma and renal cell carcinoma. The patient died of a widespread disease 13 months after surgery. This tumor is considered a primary renal angiosarcom...

In-vivo optical detection of cancer using chlorin e6 - polyvinylpyrrolidone induced fluorescence imaging and spectroscopy

BMC Medical Imaging - Latest articles — Thu, 08 Jan 2009 05:00:00 +0100

Conclusions: Combination of Ce6-PVP induced fluorescence imaging and spectroscopy could allow for optical detection and discrimination between cancer and the surrounding normal tissues. Ce6-PVP seems to be a promising fluorophore for fluorescence diagnosis of cancer. (Source: BMC Medical Imaging - Latest articles)

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In-vivo optical detection of cancer using chlorin e6 – polyvinylpyrrolidone induced fluorescence imaging and spectroscopy

BMC Medical Imaging - Latest articles — Thu, 08 Jan 2009 05:00:00 +0100

Conclusion: Combination of Ce6-PVP induced fluorescence imaging and spectroscopy could allow for optical detection and discrimination between cancer and the surrounding normal tissues. Ce6-PVP seems to be a promising fluorophore for fluorescence diagnosis of cancer. (Source: BMC Medical Imaging - Latest articles)

Treatment and outcome of radiation-induced soft-tissue sarcomas at a specialist institution.

European Journal of Surgical Oncology — Sat, 27 Dec 2008 05:00:00 +0100

CONCLUSION: RIS is a biologically aggressive tumour with high rates of local relapse despite aggressive attempts at curative surgery. PMID: 19112005 [PubMed - as supplied by publisher] (Source: European Journal of Surgical Oncology)

The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: New potential therapeutic targets?

Lung Cancer — Fri, 19 Dec 2008 00:00:00 +0100

Abstract: Malignant epitheloid vascular tumors (epitheloid haemangioendotheliomas and angiosarcomas) of the lung are very rare lesions often posing difficulties in diagnosis. Due to their rare incidence no standardized therapy regimen is established. Surgical resection of the tumor is the mainstay of treatment, but in many cases, especially due to the multifocality of the tumor, negative resection margins cannot be achieved. A blockade of members of the vascular endothelial growth factor (VEGF) system either by antibodies for their ligands or by kinase inhibitors has been increasingly used for the therapy of solid tumors. The aim of our study was to highlight the main distinguishing morphological factors between the two entities for diagnostic purposes. Next, we investigated several factor...

The VEGF-system in primary pulmonary angiosarcomas and haemangioendotheliomas: New potential therapeutic targets?

Lung Cancer — Wed, 17 Dec 2008 05:00:00 +0100

Authors: Stacher E, Gruber-Mösenbacher U, Halbwedl I, Tos AP, Cavazza A, Papotti M, Carvalho L, Huber M, Ermert L, Popper HH Malignant epitheloid vascular tumors (epitheloid haemangioendotheliomas and angiosarcomas) of the lung are very rare lesions often posing difficulties in diagnosis. Due to their rare incidence no standardized therapy regimen is established. Surgical resection of the tumor is the mainstay of treatment, but in many cases, especially due to the multifocality of the tumor, negative resection margins cannot be achieved. A blockade of members of the vascular endothelial growth factor (VEGF) system either by antibodies for their ligands or by kinase inhibitors has been increasingly used for the therapy of solid tumors. The aim of our study was to highlight the main...

Liver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection

Cancer Letters — Wed, 17 Dec 2008 00:00:00 +0100

Abstract: The incidence of liver cancer is high in all low-resource regions of the world, with the exception of Northern Africa and Western Asia. The estimated worldwide number of new cases of liver cancer in 2002 is 600,000, of which 82% are from developing countries. Given the poor survival from this disease, the estimated number of deaths is similar to that of new cases.Hepatocellular carcinoma (HCC) is the main form of liver cancer. A part from chronic infections with Hepatitis B and Hepatitis C viruses, which are the main causes of HCC, contamination of foodstuff with aflatoxins, a group of mycotoxins produced by the fungi Aspergillus flavus and Aspergillus parasiticus, is an important contributor to HCC burden in many low-income country. Alcoholic cirrhosis is an important risk facto...

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Liver cancer: Descriptive epidemiology and risk factors other than HBV and HCV infection.

Cancer Letters — Mon, 15 Dec 2008 05:00:00 +0100

Authors: Chuang SC, Vecchia CL, Boffetta P The incidence of liver cancer is high in all low-resource regions of the world, with the exception of Northern Africa and Western Asia. The estimated worldwide number of new cases of liver cancer in 2002 is 600,000, of which 82% are from developing countries. Given the poor survival from this disease, the estimated number of deaths is similar to that of new cases. Hepatocellular carcinoma (HCC) is the main form of liver cancer. A part from chronic infections with Hepatitis B and Hepatitis C viruses, which are the main causes of HCC, contamination of foodstuff with aflatoxins, a group of mycotoxins produced by the fungi Aspergillus flavus and Aspergillus parasiticus, is an important contributor to HCC burden in many low-income country. Alcoholi...

Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp

British Journal of Dermatology — Wed, 10 Dec 2008 05:00:00 +0100

(Source: British Journal of Dermatology)

Major response to paclitaxel combined with irradiation as second-line therapy in metastatic angiosarcoma of the face and scalp.

The British Journal of Dermatology — Wed, 10 Dec 2008 05:00:00 +0100

Authors: Hofmann UB, Wobser M, Kneitz H, Kleine P, Becker JC, Bröcker EB, Ugurel S PMID: 19077074 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)

Mice transgenic with SV40-late-promoter-driven Polyomavirus Middle T oncogene exclusively develop hemangiomas.

Transgenic Research — Tue, 09 Dec 2008 05:00:00 +0100

Authors: Xu Q, Chen W, Wang Z, Zheng J, Zhang Z In order to develop a model system of infantile hemangioma, transgenic mice were developed carrying the Polyomavirus Middle T (PyMT) gene driven by the SV40 late promoter. From the 520 fertilized eggs surviving microinjection, there were 25 live births. Three of these showed the hemangioma phenotype and carried and expressed the PyMT gene; the remaining descendants were normal. The tumors showed abnormal vascular proliferation with cavernous hemangioma-like structures in the skin surface, tongue, ear mucosa and gastric mucosal tissue in the transgenic mice with hemangioma phenotype. Immunohistochemical staining for Ki-67 was negative, showing the tumors were hemangiomas rather than angiosarcomas. None of the PyMT transgenic mice survived ...

Spontaneous Regression of Pulmonary Metastases from Breast Angiosarcoma

Sarcoma — Wed, 03 Dec 2008 15:16:45 +0100

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COX-2 Expression in Highly Aggressive Thyroid Malignancies – Indication for a Possible Therapeutic Option?

Hormone and Metabolic Research — Wed, 03 Dec 2008 13:24:51 +0100

Horm Metab ResDOI: 10.1055/s-0028-1102944AbstractBoth anaplastic thyroid carcinoma (ATC) and angiosarcoma of the thyroid (AST) are highly aggressive malignancies with very limited therapeutic options. Since selective inhibition of COX-2, for example, by celecoxib has been shown to suppress both tumour formation and progression, we investigated COX-2 protein expression in a series of ATC and AST (26 cases each) using immunohistochemistry. COX-2 expression was demonstrated in 13 ATC (50%) and 11 AST (42%); a strong COX-2 expression in more than 50% of vital tumour cells was found in 5 ATC and 5 AST, respectively. Although a recently performed phase II trial applying celecoxib failed overall to halt tumour progression in differentiated thyroid carcinoma, the two cases with partial or complete...

BRCA Mutations and the Risk of Angiosarcoma After Breast Cancer Treatment.

Clinical Breast Cancer — Mon, 01 Dec 2008 05:00:00 +0100

Authors: West JG, Weitzel JN, Tao ML, Carpenter M, West JE, Fanning C Post-breast cancer treatment-related angiosarcomas were first observed in lymphedematous extremities after mastectomy and are now being reported with increasing frequency after lumpectomy and radiation. A case history is presented of a BRCA2 carrier who had a postmastectomy chest wall angiosarcoma but had neither therapeutic radiation nor clinically evident lymphedema. The absence of established risk factors led to speculation that the BRCA2 germline mutation could be a causative factor in the development of this patient's angiosarcoma. A literature review supported this concept. PMID: 19073510 [PubMed - in process] (Source: Clinical Breast Cancer)

Intravascular papillary endothelial hyperplasia (Masson lesion) of the hypopharynx and larynx.

Ear, Nose and Throat Journal — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Güvenç MG, Dereköylü L, Korkut N, Oz F, Oz B Masson lesion is characterized by a benign intravascular papillary hyperplasia and subsequent thrombosis. Clinically, this lesion can be misdiagnosed as mucocele, hemangioma, Kaposi sarcoma, angiosarcoma, pyogenic granuloma, and several other lesions. In this article, we report a case of intravascular papillary endothelial hyperplasia of the hypopharynx and larynx, which caused dysphagia in an 18-year-old female patient. The lesion was excised entirely via a lateral pharyngotomy approach. We discuss the clinical and histopathologic features, differential diagnosis, and treatment of this uncommon entity. PMID: 19105147 [PubMed - in process] (Source: Ear, Nose and Throat Journal)

Angiosarcoma of the scalp.

The American Surgeon — Mon, 01 Dec 2008 05:00:00 +0100

Authors: Stokes MC, Bennett J, Beech DJ, Ballard B PMID: 19097549 [PubMed - in process] (Source: The American Surgeon)